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Search of human proteins with 4507361
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507361 mitogen-activated protein kinase kinase kinase 7
isoform A [Homo sapiens]
(579 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 1164 0.0
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 1149 0.0
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 974 0.0
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 959 0.0
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 184 3e-46
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 171 2e-42
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 166 5e-41
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 165 9e-41
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 163 4e-40
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 163 5e-40
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 155 1e-37
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 155 1e-37
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 152 1e-36
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 151 2e-36
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 136 5e-32
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 134 2e-31
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 127 2e-29
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 127 4e-29
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 127 4e-29
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 127 4e-29
gi|9910146 chromosome 21 open reading frame 7 [Homo sapiens] 127 4e-29
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 125 1e-28
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 125 1e-28
gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 125 1e-28
gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 125 1e-28
gi|148596974 TXK tyrosine kinase [Homo sapiens] 124 3e-28
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 124 3e-28
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 123 5e-28
gi|4758282 ephrin receptor EphA7 [Homo sapiens] 123 5e-28
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 121 2e-27
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 1164 bits (3011), Expect = 0.0
Identities = 579/579 (100%), Positives = 579/579 (100%)
Query: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
Sbjct: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
Query: 61 AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
Sbjct: 61 AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
Query: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
Sbjct: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
Query: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
Sbjct: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
Sbjct: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
Query: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
Sbjct: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
Query: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTGNGQPRRRSIQDLTVTG 420
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTGNGQPRRRSIQDLTVTG
Sbjct: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTGNGQPRRRSIQDLTVTG 420
Query: 421 TEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQL 480
TEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQL
Sbjct: 421 TEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQL 480
Query: 481 QPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRL 540
QPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRL
Sbjct: 481 QPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRL 540
Query: 541 VQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS 579
VQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS
Sbjct: 541 VQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS 579
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 1149 bits (2973), Expect = 0.0
Identities = 579/606 (95%), Positives = 579/606 (95%), Gaps = 27/606 (4%)
Query: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
Sbjct: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
Query: 61 AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
Sbjct: 61 AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
Query: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
Sbjct: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
Query: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
Sbjct: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
Sbjct: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
Query: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
Sbjct: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
Query: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATT----------------- 403
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATT
Sbjct: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420
Query: 404 ----------GNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 453
GNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
Sbjct: 421 ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 480
Query: 454 WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI 513
WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI
Sbjct: 481 WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEI 540
Query: 514 ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ 573
ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ
Sbjct: 541 ALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQ 600
Query: 574 KRQGTS 579
KRQGTS
Sbjct: 601 KRQGTS 606
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 974 bits (2517), Expect = 0.0
Identities = 482/486 (99%), Positives = 482/486 (99%)
Query: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
Sbjct: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
Query: 61 AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
Sbjct: 61 AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
Query: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
Sbjct: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
Query: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
Sbjct: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
Sbjct: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
Query: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
Sbjct: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
Query: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTGNGQPRRRSIQDLTVTG 420
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTGNGQPRRRSIQDLTVTG
Sbjct: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTGNGQPRRRSIQDLTVTG 420
Query: 421 TEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQL 480
TEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQL
Sbjct: 421 TEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQL 480
Query: 481 QPLAPC 486
Q C
Sbjct: 481 QARTSC 486
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 959 bits (2479), Expect = 0.0
Identities = 482/513 (93%), Positives = 482/513 (93%), Gaps = 27/513 (5%)
Query: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV
Sbjct: 1 MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
Query: 61 AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE
Sbjct: 61 AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAE 120
Query: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
Sbjct: 121 PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC 180
Query: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM
Sbjct: 181 DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIM 240
Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY
Sbjct: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
Query: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
Sbjct: 301 PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ 360
Query: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATT----------------- 403
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATT
Sbjct: 361 SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGN 420
Query: 404 ----------GNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 453
GNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP
Sbjct: 421 ILDVPEIVISGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHP 480
Query: 454 WTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPC 486
WTPDDSTDTNGSDNSIPMAYLTLDHQLQ C
Sbjct: 481 WTPDDSTDTNGSDNSIPMAYLTLDHQLQARTSC 513
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 184 bits (466), Expect = 3e-46
Identities = 107/278 (38%), Positives = 158/278 (56%), Gaps = 21/278 (7%)
Query: 21 APSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV---- 76
AP+ + +EI + E+++EE++G G FG V +A WR ++VA+K + E+ +
Sbjct: 83 APAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQV 142
Query: 77 --ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMS 132
E R + HPNI+ L GACLNP +CLVMEYA GG+L VL G P+ ++
Sbjct: 143 CQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVL----VN 198
Query: 133 WCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QT 184
W +Q ++G+ YLH+ P +IHRDLK N+L++ TVLKI DFG A + +T
Sbjct: 199 WAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT 258
Query: 185 HMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH 244
+ G+ AWMAPEV S +S+ DV+S+G++LWE++T P+ EI A A++
Sbjct: 259 TKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMN 318
Query: 245 NGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVK 282
T P+ P+P L+ CW DP RP I+K
Sbjct: 319 KLTL-PIPSTCPEPFARLLEECWDPDPHGRPDFGSILK 355
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 171 bits (432), Expect = 2e-42
Identities = 126/414 (30%), Positives = 205/414 (49%), Gaps = 58/414 (14%)
Query: 27 NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84
+F +I + +++ E G G+FG V +AKW + K+VA+K++ + E++A I LS +
Sbjct: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60
Query: 85 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
+H NI++ YG L P +V EYA GSLY+ ++ H M+W ++G+
Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119
Query: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200
YLH P +IHRDLK N+++ A G VLKICDFG A H T+ G+ WMAPEV
Sbjct: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177
Query: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259
+ SE CD +S+G++LWE++TR PF + G ++ W V R + + P+
Sbjct: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235
Query: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319
L+ +CW D +RPS ++I+ I+ E SN S
Sbjct: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269
Query: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379
D ++ NK++ E + AT + +K+LE L + + + RL + + + +
Sbjct: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328
Query: 380 P---PTS---------EGKRMSADMSEIEARIAATT-GNGQPRRRSIQDLTVTG 420
P P + E K ++ +E+ +I AT+ G G S+Q + + G
Sbjct: 329 PLLLPLAARMSEESYFESKTEESNSAEMSCQITATSNGEGHGMNPSLQAMMLMG 382
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 166 bits (420), Expect = 5e-41
Identities = 110/301 (36%), Positives = 158/301 (52%), Gaps = 26/301 (8%)
Query: 3 TASAASSSSSSSAGE--MIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV 60
T +A SS GE P Q+L EID+ E+ +EE++G G FG V +A W +V
Sbjct: 112 TPRSAFSSRCQPGGEDPSCYPPIQLL---EIDFAELTLEEIIGIGGFGKVYRAFWIGDEV 168
Query: 61 AIKQIESESER--KAFIVELRQLSRV----NHPNIVKLYGACLNP--VCLVMEYAEGGSL 112
A+K + + I +RQ +++ HPNI+ L G CL +CLVME+A GG L
Sbjct: 169 AVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPL 228
Query: 113 YNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA------ 166
VL G P ++W +Q ++G+ YLH +IHRDLK N+L++
Sbjct: 229 NRVLSGKRIPPDIL----VNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGD 284
Query: 167 -GGTVLKICDFGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT 224
+LKI DFG A + +T + G+ AWMAPEV S +S+ DV+S+G++LWE++T
Sbjct: 285 LSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT 344
Query: 225 RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIM 284
PF I G A A+ N P+ P+P LM CW+ DP RPS I+ +
Sbjct: 345 GEVPFRGIDGLAVAYGVAM-NKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403
Query: 285 T 285
T
Sbjct: 404 T 404
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 165 bits (418), Expect = 9e-41
Identities = 114/361 (31%), Positives = 183/361 (50%), Gaps = 45/361 (12%)
Query: 27 NFEEIDYKEIEVEEVVGRGAFGVVCKAKW--RAKDVAIKQIESESERKAFIVELRQLSRV 84
+F +I + +++ E G G+FG V +AKW + K+VA+K++ + E++A I LS +
Sbjct: 7 SFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-LKIEKEAEI-----LSVL 60
Query: 85 NHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
+H NI++ YG L P +V EYA GSLY+ ++ H M+W ++G+
Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRS-EEMDMDHIMTWATDVAKGMH 119
Query: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEV 200
YLH P +IHRDLK N+++ A G VLKICDFG A H T+ G+ WMAPEV
Sbjct: 120 YLHMEAPVKVIHRDLKSRNVVIAADG-VLKICDFG-ASRFHNHTTHMSLVGTFPWMAPEV 177
Query: 201 FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMW-AVHNGTRPPLIKNLPKPI 259
+ SE CD +S+G++LWE++TR PF + G ++ W V R + + P+
Sbjct: 178 IQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG--LQVAWLVVEKNERLTIPSSCPRSF 235
Query: 260 ESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSF 319
L+ +CW D +RPS ++I+ I+ E SN S
Sbjct: 236 AELLHQCWEADAKKRPSFKQIISIL----------------------ESMSNDT----SL 269
Query: 320 MDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESL 379
D ++ NK++ E + AT + +K+LE L + + + RL + + + +
Sbjct: 270 PDKCNSFLHNKAEWRCE-IEATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNT 328
Query: 380 P 380
P
Sbjct: 329 P 329
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 163 bits (413), Expect = 4e-40
Identities = 137/486 (28%), Positives = 220/486 (45%), Gaps = 69/486 (14%)
Query: 22 PSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV----- 76
PS+ + + ++ +E++E++G G FG V +A W+ ++VA+K + E+ A
Sbjct: 110 PSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVR 169
Query: 77 -ELRQLSRVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAA----- 128
E R + + HPNI++L G CL +CLV+E+A GG+L L A P A
Sbjct: 170 REARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRA 229
Query: 129 -----HAM-SWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICD 175
H + +W +Q ++G+ YLH ++HRDLK N+LL+ LKI D
Sbjct: 230 RRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITD 289
Query: 176 FGTACDI-QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGG 234
FG A + +T + G+ AWMAPEV + S +S+ D++S+G++LWE++T P+ I G
Sbjct: 290 FGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDG 349
Query: 235 PAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPS----MEEIVKIMTHLMRY 290
A AV+ T P+ P+P LM CW +DP RPS +E++ I +M
Sbjct: 350 LAVAYGVAVNKLTL-PIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTE 408
Query: 291 FPGA-------DEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNM-----EQV 338
P D L+ Q DE ++ ++ KS + +Q+
Sbjct: 409 MPQESFHSMQDDWKLEIQ-QMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQL 467
Query: 339 PATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEAR 398
+ E +L Q Q+ + G + S ++ +G R+S S+ + +
Sbjct: 468 AEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLK----LKDGHRISLP-SDFQHK 522
Query: 399 IAATTGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDD 458
I +RRS+ +S SSSP S PT R+ T D+
Sbjct: 523 ITVQASPNLDKRRSL-------------NSSSSSP------PSSPTMMPRLRAIQLTSDE 563
Query: 459 STDTNG 464
S T G
Sbjct: 564 SNKTWG 569
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 163 bits (412), Expect = 5e-40
Identities = 141/514 (27%), Positives = 233/514 (45%), Gaps = 60/514 (11%)
Query: 29 EEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIV------ELRQLS 82
E ++E+ +EEV+G G FG V + WR + VA+K + + + E R +
Sbjct: 110 EVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFA 169
Query: 83 RVNHPNIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 140
+ HPNI+ L CL +CLVMEYA GG L L G P+ ++W +Q ++G
Sbjct: 170 MLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVL----VNWAVQIARG 225
Query: 141 VAYLHSMQPKALIHRDLKPPNLLLVAG-------GTVLKICDFGTACDI-QTHMTNNKGS 192
+ YLH +IHRDLK N+LL+ LKI DFG A + +T + G+
Sbjct: 226 MHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGT 285
Query: 193 AAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLI 252
AWMAPEV + S +S+ DV+S+G++LWE++T P+ I A AV+ T P+
Sbjct: 286 YAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL-PIP 344
Query: 253 KNLPKPIESLMTRCWSKDPSQRPS----MEEIVKIMTHLMRYFP-GADEPLQYPCQYSDE 307
P+P LM CW++DP +RP ++++ + ++R P + +Q + +
Sbjct: 345 STCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQ 404
Query: 308 GQSNSATSTGSFM---DIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAK---QQS 361
G + + + + T + + + EQ+ + + E ++ + + QQ
Sbjct: 405 GLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQV 464
Query: 362 ESGRLSLGASRGSSVES-LPPTSEGKRMSADMSEIEARIAATTGNGQPRRRSI------- 413
+ R + RG+ S L G+R+S + + + RI G RRR++
Sbjct: 465 DRERPHVRRRRGTFKRSKLRARDGGERISMPL-DFKHRITVQASPGLDRRRNVFEVGPGD 523
Query: 414 -------QDLTVTGTEPGQVSSR--------SSSPSVRMITTSGPTSEKPTRSHPW---- 454
+ + + EPGQ R SS+ R GP+S KP +
Sbjct: 524 SPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRS 583
Query: 455 TPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPN 488
D++T SD+S P+ + L P P+
Sbjct: 584 RMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPS 617
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 155 bits (391), Expect = 1e-37
Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)
Query: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85
+ EIE E++G G+FG V K + R K VAIK+ S+S+ F E+ L ++N
Sbjct: 458 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 517
Query: 86 HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
HP +++ GACLN +V +Y GGSL+++LH E + + ++G+
Sbjct: 518 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 575
Query: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198
YLH++ + +IHRDL N+LL G + + DFG + +Q+ +MT G+ WMAP
Sbjct: 576 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 633
Query: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257
EVF + + Y+ K DVFS+ + LWE++T PF + A A H+ RPP+ ++PK
Sbjct: 634 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 692
Query: 258 PIESLMTRCWSKDPSQRPSMEEIV 281
PI SL+ R W+ P RP E+V
Sbjct: 693 PISSLLIRGWNACPEGRPEFSEVV 716
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 155 bits (391), Expect = 1e-37
Identities = 96/264 (36%), Positives = 147/264 (55%), Gaps = 18/264 (6%)
Query: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE-----SESERKAFIVELRQLSRVN 85
+ EIE E++G G+FG V K + R K VAIK+ S+S+ F E+ L ++N
Sbjct: 559 LQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLN 618
Query: 86 HPNIVKLYGACLNP---VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVA 142
HP +++ GACLN +V +Y GGSL+++LH E + + ++G+
Sbjct: 619 HPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLH--EQKRILDLQSKLIIAVDVAKGME 676
Query: 143 YLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT----HMTNNKGSAAWMAP 198
YLH++ + +IHRDL N+LL G + + DFG + +Q+ +MT G+ WMAP
Sbjct: 677 YLHNLT-QPIIHRDLNSHNILLYEDGHAV-VADFGESRFLQSLDEDNMTKQPGNLRWMAP 734
Query: 199 EVF-EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPK 257
EVF + + Y+ K DVFS+ + LWE++T PF + A A H+ RPP+ ++PK
Sbjct: 735 EVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHH-IRPPIGYSIPK 793
Query: 258 PIESLMTRCWSKDPSQRPSMEEIV 281
PI SL+ R W+ P RP E+V
Sbjct: 794 PISSLLIRGWNACPEGRPEFSEVV 817
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 152 bits (383), Expect = 1e-36
Identities = 86/257 (33%), Positives = 140/257 (54%), Gaps = 19/257 (7%)
Query: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
E+ ++EI + VG GA G V ++ ++VA+K++ E +++ L ++ HPNI
Sbjct: 119 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKE-----TDIKHLRKLKHPNI 173
Query: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
+ G C C++ME+ G LY VL P+ T + + W + + G+ YLH
Sbjct: 174 ITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPV---TPSLLVDWSMGIAGGMNYLHLH 230
Query: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
+ +IHRDLK PN+L+ V+KI DFGT+ ++ T G+ AWMAPEV
Sbjct: 231 K---IIHRDLKSPNMLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 286
Query: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
SEK D++S+G++LWE++T P+ ++ A I+W V N P+ + P + L+
Sbjct: 287 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSSCPDGFKILLR 344
Query: 265 RCWSKDPSQRPSMEEIV 281
+CW+ P RPS +I+
Sbjct: 345 QCWNSKPRNRPSFRQIL 361
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 151 bits (381), Expect = 2e-36
Identities = 88/255 (34%), Positives = 135/255 (52%), Gaps = 19/255 (7%)
Query: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNI 89
E+ ++EI + +G GA G V K+RA++VAIK++ ++E +++ L ++ HPNI
Sbjct: 162 EVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNE-----TDIKHLRKLKHPNI 216
Query: 90 VKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 147
+ G C C++MEY G LY VL + T + W + G+ YLH
Sbjct: 217 IAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKI---TPRLLVDWSTGIASGMNYLHLH 273
Query: 148 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--GSAAWMAPEVFEGSN 205
+ +IHRDLK PN+L+ V KI DFGT+ ++ T G+ AWMAPEV
Sbjct: 274 K---IIHRDLKSPNVLVTHTDAV-KISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEP 329
Query: 206 YSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAV-HNGTRPPLIKNLPKPIESLMT 264
SEK D++S+G++LWE++T P+ ++ A I+W V N P+ P + LM
Sbjct: 330 VSEKVDIWSFGVVLWELLTGEIPYKDVDSSA--IIWGVGSNSLHLPVPSTCPDGFKILMK 387
Query: 265 RCWSKDPSQRPSMEE 279
+ W P RPS +
Sbjct: 388 QTWQSKPRNRPSFRQ 402
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 136 bits (343), Expect = 5e-32
Identities = 92/268 (34%), Positives = 139/268 (51%), Gaps = 17/268 (6%)
Query: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAK-DVAIKQI-ESESERKAFIVELRQLSRVNHP 87
EI+ E+ +G G FGVV KWRA+ VAIK I E + FI E + + ++ HP
Sbjct: 364 EINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHP 423
Query: 88 NIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 145
+V+LYG C P+ +V E+ E G L N L + +++ +S C +G+ YL
Sbjct: 424 KLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG--HFSRDVLLSMCQDVCEGMEYL- 480
Query: 146 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----DIQTHMTNNKGSAAWMAPEVF 201
+ + IHRDL N L+ G V+K+ DFG A D T + K W PEVF
Sbjct: 481 --ERNSFIHRDLAARNCLVSEAG-VVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVF 537
Query: 202 EGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIE 260
S +S K DV+S+G+++WEV T R PF++ + ++ V G R K +
Sbjct: 538 NYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTN--YEVVTMVTRGHRLYQPKLASNYVY 595
Query: 261 SLMTRCWSKDPSQRPSMEEIVKIMTHLM 288
+M RCW + P RPS E++++ + L+
Sbjct: 596 EVMLRCWQEKPEGRPSFEDLLRTIDELV 623
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 134 bits (337), Expect = 2e-31
Identities = 88/266 (33%), Positives = 132/266 (49%), Gaps = 17/266 (6%)
Query: 31 IDYKEIEVEEVVGRGAFGVVCKAKWRAKD-VAIKQI-ESESERKAFIVELRQLSRVNHPN 88
ID E+ + +G G FG+V W KD VAIK I E + FI E + +++HP
Sbjct: 358 IDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPK 417
Query: 89 IVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHS 146
+V+LYG CL P+CLV E+ E G L + L L + A + CL +G+AYL
Sbjct: 418 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL--FAAETLLGMCLDVCEGMAYL-- 473
Query: 147 MQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----DIQTHMTNNKGSAAWMAPEVFE 202
+ +IHRDL N L V V+K+ DFG D T T K W +PEVF
Sbjct: 474 -EEACVIHRDLAARNCL-VGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFS 531
Query: 203 GSNYSEKCDVFSWGIILWEVITRRK-PFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIES 261
S YS K DV+S+G+++WEV + K P++ ++ + G R + +
Sbjct: 532 FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNS--EVVEDISTGFRLYKPRLASTHVYQ 589
Query: 262 LMTRCWSKDPSQRPSMEEIVKIMTHL 287
+M CW + P RP+ +++ + +
Sbjct: 590 IMNHCWKERPEDRPAFSRLLRQLAEI 615
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 127 bits (320), Expect = 2e-29
Identities = 93/291 (31%), Positives = 146/291 (50%), Gaps = 31/291 (10%)
Query: 20 EAPSQVLN--FEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKD-----VAIKQIE---SES 69
E P+Q ++ +E+D I +++VVG G FG VC + + VAIK ++ +E
Sbjct: 603 EDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEK 662
Query: 70 ERKAFIVELRQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYNVL--HGAEPLPYY 125
+R+ F+ E + + +HPNI++L G PV +V EY E GSL + L H A+ +
Sbjct: 663 QRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ----F 718
Query: 126 TAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----D 181
T + + G+ YL M +HRDL N+L + V K+ DFG + D
Sbjct: 719 TVIQLVGMLRGIASGMKYLSDM---GYVHRDLAARNIL-INSNLVCKVSDFGLSRVLEDD 774
Query: 182 IQTHMTNNKGSAA--WMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFR 238
+ T G W +PE ++ DV+S+GI+LWEV++ +P+ E+
Sbjct: 775 PEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQD-- 832
Query: 239 IMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
++ AV G R P + P + LM CW KD + RP E+IV I+ L+R
Sbjct: 833 VIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIR 883
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 127 bits (318), Expect = 4e-29
Identities = 80/280 (28%), Positives = 144/280 (51%), Gaps = 14/280 (5%)
Query: 12 SSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER 71
+ SA E + +LN + + + +G G FG V + ++ + VA+K I+ +
Sbjct: 175 TKSAEEELARAGWLLNLQHLT-----LGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTA 229
Query: 72 KAFIVELRQLSRVNHPNIVKLYGACLNP-VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHA 130
+AF+ E ++++ H N+V+L G L+ + +VME+ G+L N L A
Sbjct: 230 QAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLR-TRGRALVNTAQL 288
Query: 131 MSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK 190
+ + L ++G+ YL S K L+HRDL N+L V+ V K+ DFG A + + +++
Sbjct: 289 LQFSLHVAEGMEYLES---KKLVHRDLAARNIL-VSEDLVAKVSDFGLAKAERKGLDSSR 344
Query: 191 GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFDEIGGPAFRIMWAVHNGTRP 249
W APE + ++ K DV+S+G++LWEV + R P+ ++ + AV G R
Sbjct: 345 LPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMS--LKEVSEAVEKGYRM 402
Query: 250 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
+ P P+ LM+ CW +P++RP ++ + + +R
Sbjct: 403 EPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELR 442
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 127 bits (318), Expect = 4e-29
Identities = 80/280 (28%), Positives = 144/280 (51%), Gaps = 14/280 (5%)
Query: 12 SSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER 71
+ SA E + +LN + + + +G G FG V + ++ + VA+K I+ +
Sbjct: 217 TKSAEEELARAGWLLNLQHLT-----LGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTA 271
Query: 72 KAFIVELRQLSRVNHPNIVKLYGACLNP-VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHA 130
+AF+ E ++++ H N+V+L G L+ + +VME+ G+L N L A
Sbjct: 272 QAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLR-TRGRALVNTAQL 330
Query: 131 MSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK 190
+ + L ++G+ YL S K L+HRDL N+L V+ V K+ DFG A + + +++
Sbjct: 331 LQFSLHVAEGMEYLES---KKLVHRDLAARNIL-VSEDLVAKVSDFGLAKAERKGLDSSR 386
Query: 191 GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFDEIGGPAFRIMWAVHNGTRP 249
W APE + ++ K DV+S+G++LWEV + R P+ ++ + AV G R
Sbjct: 387 LPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMS--LKEVSEAVEKGYRM 444
Query: 250 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
+ P P+ LM+ CW +P++RP ++ + + +R
Sbjct: 445 EPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELR 484
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 127 bits (318), Expect = 4e-29
Identities = 80/280 (28%), Positives = 144/280 (51%), Gaps = 14/280 (5%)
Query: 12 SSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESER 71
+ SA E + +LN + + + +G G FG V + ++ + VA+K I+ +
Sbjct: 216 TKSAEEELARAGWLLNLQHLT-----LGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTA 270
Query: 72 KAFIVELRQLSRVNHPNIVKLYGACLNP-VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHA 130
+AF+ E ++++ H N+V+L G L+ + +VME+ G+L N L A
Sbjct: 271 QAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLR-TRGRALVNTAQL 329
Query: 131 MSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK 190
+ + L ++G+ YL S K L+HRDL N+L V+ V K+ DFG A + + +++
Sbjct: 330 LQFSLHVAEGMEYLES---KKLVHRDLAARNIL-VSEDLVAKVSDFGLAKAERKGLDSSR 385
Query: 191 GSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFDEIGGPAFRIMWAVHNGTRP 249
W APE + ++ K DV+S+G++LWEV + R P+ ++ + AV G R
Sbjct: 386 LPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMS--LKEVSEAVEKGYRM 443
Query: 250 PLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
+ P P+ LM+ CW +P++RP ++ + + +R
Sbjct: 444 EPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELR 483
>gi|9910146 chromosome 21 open reading frame 7 [Homo sapiens]
Length = 242
Score = 127 bits (318), Expect = 4e-29
Identities = 62/124 (50%), Positives = 89/124 (71%)
Query: 456 PDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIAL 515
P D ++SIP+ + LD QLQPL PC +S+ESM VF+QHC++A+EY +V+ EI L
Sbjct: 119 PSSPLDDTPPEDSIPLVFPELDQQLQPLPPCHDSEESMEVFKQHCQIAEEYHEVKKEITL 178
Query: 516 LLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKR 575
L QRK+EL+A+LDQ EK++ + + LV+E + L +EN++L QC +QLE +R Q QKR
Sbjct: 179 LEQRKKELIAKLDQAEKEKVDAAELVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKR 238
Query: 576 QGTS 579
QG+S
Sbjct: 239 QGSS 242
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
sapiens]
Length = 1015
Score = 125 bits (313), Expect = 1e-28
Identities = 95/322 (29%), Positives = 153/322 (47%), Gaps = 27/322 (8%)
Query: 20 EAPSQVLN--FEEIDYKEIEVEEVVGRGAFGVVCKAKW-----RAKDVAIKQIE---SES 69
E P+Q ++ +EI+ I +E V+G G FG VC + R VAIK ++ +E
Sbjct: 635 EDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK 694
Query: 70 ERKAFIVELRQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTA 127
+R+ F+ E + + +HPNI+ L G PV +V EY E GSL L + +T
Sbjct: 695 QRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDG--QFTV 752
Query: 128 AHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----DIQ 183
+ S G+ YL M +HRDL N+L + V K+ DFG + D +
Sbjct: 753 IQLVGMLRGISAGMKYLSDM---GYVHRDLAARNIL-INSNLVCKVSDFGLSRVLEDDPE 808
Query: 184 THMTNNKGSAA--WMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIM 240
T G W APE ++ DV+S+GI++WEV++ +P+ E+ ++
Sbjct: 809 AAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD--VI 866
Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
AV G R P + P + LM CW K+ + RP +EIV ++ L+R +
Sbjct: 867 KAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNA 926
Query: 301 PCQYSDEGQSNSATSTGSFMDI 322
C+ S+ +S +G++ +
Sbjct: 927 SCRVSNLLAEHSPLGSGAYRSV 948
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
sapiens]
Length = 1037
Score = 125 bits (313), Expect = 1e-28
Identities = 95/322 (29%), Positives = 153/322 (47%), Gaps = 27/322 (8%)
Query: 20 EAPSQVLN--FEEIDYKEIEVEEVVGRGAFGVVCKAKW-----RAKDVAIKQIE---SES 69
E P+Q ++ +EI+ I +E V+G G FG VC + R VAIK ++ +E
Sbjct: 657 EDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK 716
Query: 70 ERKAFIVELRQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTA 127
+R+ F+ E + + +HPNI+ L G PV +V EY E GSL L + +T
Sbjct: 717 QRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDG--QFTV 774
Query: 128 AHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC----DIQ 183
+ S G+ YL M +HRDL N+L + V K+ DFG + D +
Sbjct: 775 IQLVGMLRGISAGMKYLSDM---GYVHRDLAARNIL-INSNLVCKVSDFGLSRVLEDDPE 830
Query: 184 THMTNNKGSAA--WMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIM 240
T G W APE ++ DV+S+GI++WEV++ +P+ E+ ++
Sbjct: 831 AAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQD--VI 888
Query: 241 WAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY 300
AV G R P + P + LM CW K+ + RP +EIV ++ L+R +
Sbjct: 889 KAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNA 948
Query: 301 PCQYSDEGQSNSATSTGSFMDI 322
C+ S+ +S +G++ +
Sbjct: 949 SCRVSNLLAEHSPLGSGAYRSV 970
>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
Length = 1072
Score = 125 bits (313), Expect = 1e-28
Identities = 97/298 (32%), Positives = 150/298 (50%), Gaps = 45/298 (15%)
Query: 30 EIDYKEIEVEEVVGRGAFGVVCKA-----KWRA--KDVAIKQIE---SESERKAFIVELR 79
E K + + + +G G FG V KA K RA VA+K ++ S SE + + E
Sbjct: 718 EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN 777
Query: 80 QLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPL-PYY----------- 125
L +VNHP+++KLYGAC P+ L++EYA+ GSL L + + P Y
Sbjct: 778 VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSS 837
Query: 126 ---------TAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDF 176
T +S+ Q SQG+ YL M+ L+HRDL N +LVA G +KI DF
Sbjct: 838 LDHPDERALTMGDLISFAWQISQGMQYLAEMK---LVHRDLAARN-ILVAEGRKMKISDF 893
Query: 177 GTACDI---QTHMTNNKG--SAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFD 230
G + D+ +++ ++G WMA E Y+ + DV+S+G++LWE++T P+
Sbjct: 894 GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 953
Query: 231 EIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLM 288
G P R+ + G R N + + LM +CW ++P +RP +I K + +M
Sbjct: 954 --GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
Length = 1114
Score = 125 bits (313), Expect = 1e-28
Identities = 97/298 (32%), Positives = 150/298 (50%), Gaps = 45/298 (15%)
Query: 30 EIDYKEIEVEEVVGRGAFGVVCKA-----KWRA--KDVAIKQIE---SESERKAFIVELR 79
E K + + + +G G FG V KA K RA VA+K ++ S SE + + E
Sbjct: 718 EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN 777
Query: 80 QLSRVNHPNIVKLYGACL--NPVCLVMEYAEGGSLYNVLHGAEPL-PYY----------- 125
L +VNHP+++KLYGAC P+ L++EYA+ GSL L + + P Y
Sbjct: 778 VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSS 837
Query: 126 ---------TAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDF 176
T +S+ Q SQG+ YL M+ L+HRDL N +LVA G +KI DF
Sbjct: 838 LDHPDERALTMGDLISFAWQISQGMQYLAEMK---LVHRDLAARN-ILVAEGRKMKISDF 893
Query: 177 GTACDI---QTHMTNNKG--SAAWMAPEVFEGSNYSEKCDVFSWGIILWEVIT-RRKPFD 230
G + D+ +++ ++G WMA E Y+ + DV+S+G++LWE++T P+
Sbjct: 894 GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 953
Query: 231 EIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLM 288
G P R+ + G R N + + LM +CW ++P +RP +I K + +M
Sbjct: 954 --GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 124 bits (310), Expect = 3e-28
Identities = 88/267 (32%), Positives = 135/267 (50%), Gaps = 17/267 (6%)
Query: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAK-DVAIKQI-ESESERKAFIVELRQLSRVNHP 87
EID E+ + +G G FGVV +WR+ VAIK I E + FI E + + +++H
Sbjct: 265 EIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHS 324
Query: 88 NIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 145
+V+LYG C+ P+ +V E+ E G L N L E +S C +G+ YL
Sbjct: 325 KLVQLYGVCIQRKPLYIVTEFMENGCLLNYLR--ENKGKLRKEMLLSVCQDICEGMEYL- 381
Query: 146 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFG-TACDIQTHMTNNKGSA---AWMAPEVF 201
+ IHRDL N L V+ ++KI DFG T + ++ G+ W PEVF
Sbjct: 382 --ERNGYIHRDLAARNCL-VSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVF 438
Query: 202 EGSNYSEKCDVFSWGIILWEVITRRK-PFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIE 260
+ YS K DV+S+G+++WEV T K PF+ +++ A+ G R P I
Sbjct: 439 LFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSN--LQVVEAISEGFRLYRPHLAPMSIY 496
Query: 261 SLMTRCWSKDPSQRPSMEEIVKIMTHL 287
+M CW + P RP+ E+++ +T +
Sbjct: 497 EVMYSCWHEKPEGRPTFAELLRAVTEI 523
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 124 bits (310), Expect = 3e-28
Identities = 119/381 (31%), Positives = 168/381 (44%), Gaps = 65/381 (17%)
Query: 40 EVVGRGAFGVVCKAK------WRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLY 93
E VG G FG V K + W A + + ER + E +++ I+ +Y
Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85
Query: 94 GACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALI 153
G C PV LVMEY E GSL +L +EPLP+ + + + G+ +LH M P L+
Sbjct: 86 GICREPVGLVMEYMETGSLEKLL-ASEPLPWDLRFRIIH---ETAVGMNFLHCMAP-PLL 140
Query: 154 HRDLKPPNLLLVAGGTVLKICDFGTA-CDIQTH-----MTNNKGSAAWMAPEVFEGSN-- 205
H DLKP N+LL A V KI DFG A C+ +H M G+ A++ PE +
Sbjct: 141 HLDLKPANILLDAHYHV-KISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPERIREKSRL 199
Query: 206 YSEKCDVFSWGIILWEVITRRKPF-DEIGGPAFRIMWAVHNGTR---PPLIKNLPKP--- 258
+ K DV+S+ I++W V+T++KPF DE IM V G R PP+ + P+
Sbjct: 200 FDTKHDVYSFAIVIWGVLTQKKPFADEKN--ILHIMVKVVKGHRPELPPVCRARPRACSH 257
Query: 259 IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGS 318
+ LM RCW DP RP+ +EI L C+ D+ T
Sbjct: 258 LIRLMQRCWQGDPRVRPTFQEITSETEDL--------------CEKPDD----EVKETAH 299
Query: 319 FMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGA-------- 370
+D+ S + E VPA +KR + N +L G
Sbjct: 300 DLDVKS-----PPEPRSEVVPA---RLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPE 351
Query: 371 --SRGSSVESLPPTSEGKRMS 389
SR SS LP + GKR+S
Sbjct: 352 ELSRSSSESKLPSSGSGKRLS 372
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 123 bits (308), Expect = 5e-28
Identities = 114/450 (25%), Positives = 185/450 (41%), Gaps = 46/450 (10%)
Query: 4 ASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDV--- 60
A+ +++ A + ++ N +++ + ++G GAFG V + A D+
Sbjct: 1913 AAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGT--AVDILGV 1970
Query: 61 ----------AIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACL--NPVCLVMEYAE 108
+K+ ++ E+ F+ E +S+ NHPNI+K G CL P +++E E
Sbjct: 1971 GSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELME 2030
Query: 109 GGSLYNVLHGAEPLPYY----TAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLL 164
GG L L A +Y T + C+ S+G YL M IHRDL N L+
Sbjct: 2031 GGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMH---FIHRDLAARNCLV 2087
Query: 165 ----VAGGTVLKICDFGTACDIQTHMTNNKGSAA-----WMAPEVFEGSNYSEKCDVFSW 215
++KI DFG A DI + K WMAPE ++ + DV+S+
Sbjct: 2088 SVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSF 2147
Query: 216 GIILWEVIT-RRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQR 274
GI++WE++T +P+ ++ V G R +N P + +LMT+CW+++P QR
Sbjct: 2148 GILIWEILTLGHQPYPAHSN--LDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQR 2205
Query: 275 PSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTN 334
P+ I + +F + S + +NS SF SD
Sbjct: 2206 PTFHRIQDQLQLFRNFFLNS-------IYKSRDEANNSGVINESFEGEDGDVICLNSDDI 2258
Query: 335 MEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSE 394
M + L +L + Q E LG+ ES E K AD
Sbjct: 2259 MPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQES---ESCGLRKEEKEPHADKDF 2315
Query: 395 IEARIAATTGNGQPRRRSIQDLTVTGTEPG 424
+ + A +G+P + LT +G G
Sbjct: 2316 CQEKQVAYCPSGKPEGLNYACLTHSGYGDG 2345
>gi|4758282 ephrin receptor EphA7 [Homo sapiens]
Length = 998
Score = 123 bits (308), Expect = 5e-28
Identities = 86/292 (29%), Positives = 146/292 (50%), Gaps = 27/292 (9%)
Query: 17 EMIEAPSQVLN--FEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKD-----VAIKQIE--- 66
E E P++ ++ +E+D I++E V+G G FG VC + + VAIK ++
Sbjct: 612 ETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGY 671
Query: 67 SESERKAFIVELRQLSRVNHPNIVKLYGACLN--PVCLVMEYAEGGSLYNVLHGAEPLPY 124
+E +R+ F+ E + + +HPN+V L G PV +V+E+ E G+L L +
Sbjct: 672 TEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDG--Q 729
Query: 125 YTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQT 184
+T + + G+ YL M +HRDL N+L V V K+ DFG + I+
Sbjct: 730 FTVIQLVGMLRGIAAGMRYLADM---GYVHRDLAARNIL-VNSNLVCKVSDFGLSRVIED 785
Query: 185 H------MTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAF 237
T K W APE + ++ DV+S+GI++WEV++ +P+ ++
Sbjct: 786 DPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQD- 844
Query: 238 RIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMR 289
++ A+ G R P + P + LM CW K+ ++RP E+IV I+ ++R
Sbjct: 845 -VIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIR 895
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 121 bits (304), Expect = 2e-27
Identities = 98/311 (31%), Positives = 157/311 (50%), Gaps = 33/311 (10%)
Query: 30 EIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIE----SESERKAFIVELRQLSRVN 85
EI+ E+ + +G G+FG V K KW DVA+K ++ + + +AF E+ L +
Sbjct: 343 EIEASEVMLSTRIGSGSFGTVYKGKWHG-DVAVKILKVVDPTPEQFQAFRNEVAVLRKTR 401
Query: 86 HPNIVKLYGACLNP-VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYL 144
H NI+ G + +V ++ EG SLY LH E + + Q +QG+ YL
Sbjct: 402 HVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK--FQMFQLIDIARQTAQGMDYL 459
Query: 145 HSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK------GSAAWMAP 198
H+ K +IHRD+K N+ L G TV KI DFG A +++ + ++ GS WMAP
Sbjct: 460 HA---KNIIHRDMKSNNIFLHEGLTV-KIGDFGLAT-VKSRWSGSQQVEQPTGSVLWMAP 514
Query: 199 EVF---EGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPP----L 251
EV + + +S + DV+S+GI+L+E++T P+ I +I++ V G P L
Sbjct: 515 EVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINN-RDQIIFMVGRGYASPDLSKL 573
Query: 252 IKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFP----GADEPLQYPCQYSDE 307
KN PK ++ L+ C K +RP +I+ + L P A EP + ++++
Sbjct: 574 YKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTED 633
Query: 308 GQSNSATSTGS 318
N+ T T S
Sbjct: 634 --INACTLTTS 642
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.127 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,316,346
Number of Sequences: 37866
Number of extensions: 1121234
Number of successful extensions: 7360
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 480
Number of HSP's successfully gapped in prelim test: 535
Number of HSP's that attempted gapping in prelim test: 4618
Number of HSP's gapped (non-prelim): 1742
length of query: 579
length of database: 18,247,518
effective HSP length: 108
effective length of query: 471
effective length of database: 14,157,990
effective search space: 6668413290
effective search space used: 6668413290
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.