Guide to the Human Genome
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Search of human proteins with 4507281

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
         (1030 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]            2086   0.0  
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]             2086   0.0  
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]              304   3e-82
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]             289   8e-78
gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]             279   8e-75
gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo sapi...   259   1e-68
gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo sapi...   259   1e-68
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   215   2e-55
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             207   4e-53
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        206   7e-53
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   206   1e-52
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           205   2e-52
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]    203   8e-52
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]    203   8e-52
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...   202   1e-51
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...   202   1e-51
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...   202   1e-51
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...   202   1e-51
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...   202   1e-51
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...   202   1e-51
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        200   7e-51
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    199   1e-50
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]    199   1e-50
gi|27477122 intestinal cell kinase [Homo sapiens]                     196   7e-50
gi|7662388 intestinal cell kinase [Homo sapiens]                      196   7e-50
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   196   7e-50
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   196   7e-50
gi|11496279 male germ cell-associated kinase [Homo sapiens]           196   9e-50
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   194   3e-49
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        184   3e-46

>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score = 2087 bits (5406), Expect = 0.0
 Identities = 1030/1030 (100%), Positives = 1030/1030 (100%)

Query: 1    MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE 60
            MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
Sbjct: 1    MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE 60

Query: 61   LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 120
            LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
Sbjct: 61   LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 120

Query: 121  KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP 180
            KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
Sbjct: 121  KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP 180

Query: 181  ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 240
            ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS
Sbjct: 181  ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 240

Query: 241  NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300
            NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ
Sbjct: 241  NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300

Query: 301  RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL 360
            RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL
Sbjct: 301  RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL 360

Query: 361  PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN 420
            PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN
Sbjct: 361  PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN 420

Query: 421  IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP 480
            IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP
Sbjct: 421  IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP 480

Query: 481  SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT 540
            SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT
Sbjct: 481  SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT 540

Query: 541  LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS 600
            LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS
Sbjct: 541  LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS 600

Query: 601  PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA 660
            PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA
Sbjct: 601  PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA 660

Query: 661  RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS 720
            RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS
Sbjct: 661  RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS 720

Query: 721  PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF 780
            PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF
Sbjct: 721  PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF 780

Query: 781  RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR 840
            RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR
Sbjct: 781  RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR 840

Query: 841  KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA 900
            KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA
Sbjct: 841  KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA 900

Query: 901  LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS 960
            LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS
Sbjct: 901  LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS 960

Query: 961  PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT 1020
            PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT
Sbjct: 961  PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT 1020

Query: 1021 YHENAALTGK 1030
            YHENAALTGK
Sbjct: 1021 YHENAALTGK 1030


>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
          Length = 1030

 Score = 2087 bits (5406), Expect = 0.0
 Identities = 1030/1030 (100%), Positives = 1030/1030 (100%)

Query: 1    MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE 60
            MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE
Sbjct: 1    MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE 60

Query: 61   LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 120
            LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI
Sbjct: 61   LKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLI 120

Query: 121  KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP 180
            KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP
Sbjct: 121  KAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSP 180

Query: 181  ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 240
            ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS
Sbjct: 181  ELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYS 240

Query: 241  NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300
            NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ
Sbjct: 241  NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300

Query: 301  RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL 360
            RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL
Sbjct: 301  RLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGL 360

Query: 361  PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN 420
            PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN
Sbjct: 361  PANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFN 420

Query: 421  IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP 480
            IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP
Sbjct: 421  IDPKPSEGPGTKYLKSNSRSQQNRHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSP 480

Query: 481  SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT 540
            SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT
Sbjct: 481  SYRTKAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRT 540

Query: 541  LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS 600
            LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS
Sbjct: 541  LLSPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTS 600

Query: 601  PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA 660
            PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA
Sbjct: 601  PFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVA 660

Query: 661  RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS 720
            RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS
Sbjct: 661  RSSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPS 720

Query: 721  PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF 780
            PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF
Sbjct: 721  PRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFF 780

Query: 781  RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR 840
            RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR
Sbjct: 781  RSMKKKKKKSQTVPNSDSPDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLR 840

Query: 841  KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA 900
            KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA
Sbjct: 841  KLLHLSSASNHPASSDPRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPA 900

Query: 901  LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS 960
            LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS
Sbjct: 901  LQLPDGGCDGRRQRHHSGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRALHRPISS 960

Query: 961  PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT 1020
            PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT
Sbjct: 961  PAPYPVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLT 1020

Query: 1021 YHENAALTGK 1030
            YHENAALTGK
Sbjct: 1021 YHENAALTGK 1030


>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
          Length = 493

 Score =  304 bits (778), Expect = 3e-82
 Identities = 171/437 (39%), Positives = 266/437 (60%), Gaps = 18/437 (4%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           M K+E LG+VGEG+YG+V+KCR+K+T  IVAIKKF +S++++ VK+  +RE+K+L+ L+ 
Sbjct: 1   MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
           EN+V L E  +++ + YLVFE+V+  +L+ LE  PNG+  + V+ Y++Q+I  I +CH +
Sbjct: 61  ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120

Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APY 188
           +I+HRDIKPEN+L+S + V+KLCDFGFAR L+      YT+YVATRWYR+PELL+G   Y
Sbjct: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAPELLVGDVKY 179

Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
           GK+VD+W++GC++ E+  G+PLFPG+S+IDQL+ I   LG L     +LF  NP F G+R
Sbjct: 180 GKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVR 239

Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
            P +   + LERRY   L+ V++DL K  L +DP  R    + L+H  FQ     +R   
Sbjct: 240 LPEIKEREPLERRY-PKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQ 298

Query: 309 RSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESF-- 366
               +      + +LS ++Q  K    +    S  ++ + L V    AD  +   + F  
Sbjct: 299 ELQLKVQKDARNVSLSKKSQNRKKE--KEKDDSLVEERKTLVVQDTNADPKIKDYKLFKI 356

Query: 367 ----LNGNLA-----GASLSPLH-TKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTE 416
               ++G  A      ++ S LH ++T      P ++ KD +N ++ H  +P  A     
Sbjct: 357 KGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLT 416

Query: 417 FDFN-IDPKPSEGPGTK 432
            + + + P  + G GT+
Sbjct: 417 HNLSAVAPSINSGMGTE 433


>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
          Length = 358

 Score =  289 bits (740), Expect = 8e-78
 Identities = 144/313 (46%), Positives = 212/313 (67%), Gaps = 9/313 (2%)

Query: 9   VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLK 68
           +M K+E +G +GEG+YGVV KCR+++T +IVAIKKF +SE++  +K+  LRE++ML+ LK
Sbjct: 1   MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK 60

Query: 69  QENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 128
             N+V L E FRR+ +L+LVFEY +  +L  L+    GVP   VKS  +Q ++A+++CHK
Sbjct: 61  HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHK 120

Query: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-AP 187
           ++ +HRD+KPEN+LI+ + V+KLCDFGFAR L+ G +  YT+YVATRWYRSPELL+G   
Sbjct: 121 HNCIHRDVKPENILITKHSVIKLCDFGFARLLT-GPSDYYTDYVATRWYRSPELLVGDTQ 179

Query: 188 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 247
           YG  VD+W++GC+  EL  G PL+PG+S++DQL+ I+K LG L     ++F +N  F G+
Sbjct: 180 YGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGV 239

Query: 248 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLD--- 304
           + P     + LE ++  I +   L L+K  L +DP  R   EQ L+HP F+  R ++   
Sbjct: 240 KIPDPEDMEPLELKFPNI-SYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLA 298

Query: 305 ---RSPSRSAKRK 314
                P+R   RK
Sbjct: 299 KEHNKPTRKTLRK 311


>gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]
          Length = 315

 Score =  279 bits (714), Expect = 8e-75
 Identities = 136/291 (46%), Positives = 199/291 (68%), Gaps = 4/291 (1%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           M K+E L   GEG+YGVV KCR+K + ++VA+KKF +SE++  VK+  LRE++ML+ LK 
Sbjct: 1   MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
            N+V L E FRR+ K++LVFEY +  +L  LE  PNGV    +KS ++Q ++A+++CH +
Sbjct: 61  PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120

Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APY 188
           + +HRDIKPEN+LI+   ++K+CDFGFA+ L  G+   YT+YVATRWYR+PELL+G   Y
Sbjct: 121 NCIHRDIKPENILITKQGIIKICDFGFAQILIPGD--AYTDYVATRWYRAPELLVGDTQY 178

Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
           G SVD+W++GC+  EL  GQPL+PG+S++DQL+ I + LG L      +F SN  FHG+ 
Sbjct: 179 GSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGIS 238

Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT 299
            P     ++LE ++  + + V L+ MK  LK++P DR    Q L    F +
Sbjct: 239 IPEPEDMETLEEKFSDV-HPVALNFMKGCLKMNPDDRLTCSQLLESSYFDS 288


>gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
           sapiens]
          Length = 592

 Score =  259 bits (661), Expect = 1e-68
 Identities = 128/332 (38%), Positives = 207/332 (62%), Gaps = 4/332 (1%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           M  +E LG VGEG+YG V+KC+HK T +IVAIK F +  E + V +  +RE+K L+    
Sbjct: 1   MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE-QSVNKIAMREIKFLKQFHH 59

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
           EN+V L E FR++ K++LVFE+++  +L+ L+   +G+  ++++ Y++Q+++AI + H N
Sbjct: 60  ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119

Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
           +I+HRDIKPEN+L+S + + KLCDFGFAR L+   +  YT+YVATRWYR+PEL+L    Y
Sbjct: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDI-YTDYVATRWYRAPELVLKDTSY 178

Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
           GK VD+W++GC++ E++ G P  P  S++D L  I   +G L      +F  +P F G+ 
Sbjct: 179 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV 238

Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
            P V HP++  ++Y   LN +L D++   L++DPADR  +   L+H  F     +++   
Sbjct: 239 LPQVQHPKNARKKY-PKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMP 297

Query: 309 RSAKRKPYHVESSTLSNRNQAGKSTALQSHHR 340
               +     + ++L    ++ K   L+   R
Sbjct: 298 ELKAKLLQEAKVNSLIKPKESSKENELRKDER 329


>gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo
           sapiens]
          Length = 455

 Score =  259 bits (661), Expect = 1e-68
 Identities = 128/332 (38%), Positives = 207/332 (62%), Gaps = 4/332 (1%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           M  +E LG VGEG+YG V+KC+HK T +IVAIK F +  E + V +  +RE+K L+    
Sbjct: 1   MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE-QSVNKIAMREIKFLKQFHH 59

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
           EN+V L E FR++ K++LVFE+++  +L+ L+   +G+  ++++ Y++Q+++AI + H N
Sbjct: 60  ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119

Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
           +I+HRDIKPEN+L+S + + KLCDFGFAR L+   +  YT+YVATRWYR+PEL+L    Y
Sbjct: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDI-YTDYVATRWYRAPELVLKDTSY 178

Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
           GK VD+W++GC++ E++ G P  P  S++D L  I   +G L      +F  +P F G+ 
Sbjct: 179 GKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVV 238

Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
            P V HP++  ++Y   LN +L D++   L++DPADR  +   L+H  F     +++   
Sbjct: 239 LPQVQHPKNARKKY-PKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMP 297

Query: 309 RSAKRKPYHVESSTLSNRNQAGKSTALQSHHR 340
               +     + ++L    ++ K   L+   R
Sbjct: 298 ELKAKLLQEAKVNSLIKPKESSKENELRKDER 329


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  215 bits (548), Expect = 2e-55
 Identities = 118/291 (40%), Positives = 174/291 (59%), Gaps = 8/291 (2%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           M K+E L  +GEG YG V K +++ETHEIVA+K+ +  +++E V  + LRE+ +L+ LK 
Sbjct: 1   MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
           +NIV L +      KL LVFE+ ++++ +  +     + PE VKS+++QL+K + +CH  
Sbjct: 61  KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120

Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP-Y 188
           +++HRD+KP+NLLI+ N  LKL DFG AR         Y+  V T WYR P++L GA  Y
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRC-YSAEVVTLWYRPPDVLFGAKLY 179

Query: 189 GKSVDMWSVGCILGELSD-GQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 247
             S+DMWS GCI  EL++ G+PLFPG    DQL  I ++LG    EQ       P +   
Sbjct: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY 239

Query: 248 -RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
             +PA     ++  +    LN+   DL++NLLK +P  R   E+ L HP F
Sbjct: 240 PMYPATTSLVNVVPK----LNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  207 bits (527), Expect = 4e-53
 Identities = 119/291 (40%), Positives = 173/291 (59%), Gaps = 7/291 (2%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           M  +  +  +GEG YGVV K RHK T ++VA+KK +   E E V  T +RE+ +L+ L+ 
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG--VPPEKVKSYIYQLIKAIHWCH 127
            NIV L++   +  +LYL+FE++  ++ + L+ +P G  +    VKSY+YQ+++ I +CH
Sbjct: 61  PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120

Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-A 186
              ++HRD+KP+NLLI     +KL DFG AR         YT  V T WYRSPE+LLG A
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV-YTHEVVTLWYRSPEVLLGSA 179

Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 246
            Y   VD+WS+G I  EL+  +PLF G+SEIDQLF I + LG  P+ ++     + + + 
Sbjct: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG-TPNNEVWPEVESLQDYK 238

Query: 247 LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
             FP    P SL   ++  L+   LDL+  +L  DPA R   +  LNHP F
Sbjct: 239 NTFPKWK-PGSL-ASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  206 bits (525), Expect = 7e-53
 Identities = 118/295 (40%), Positives = 170/295 (57%), Gaps = 4/295 (1%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           M+++ ILG +GEGA+G+V K +H ET EIVA+KK       +      LRE+K L+ ++ 
Sbjct: 1   MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60

Query: 70  EN-IVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 128
              +V+LK  F   G   L FE++  ++ E++      +   +VKSY+  L+K + +CH 
Sbjct: 61  NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120

Query: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA-P 187
           N+IVHRD+KP NLLIS +  LK+ DFG AR  S   +  YT  VATRWYR+PELL GA  
Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ 180

Query: 188 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 247
           Y + VD+WSVGCI+GEL +G PLFPG+++I+QL  + ++LG    +        P ++ +
Sbjct: 181 YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 240

Query: 248 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRL 302
            F     P  LE   L  ++   LDL+   L   P  R    + L H  F T  L
Sbjct: 241 SFKE-QVPMPLE-EVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPL 293


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  206 bits (523), Expect = 1e-52
 Identities = 114/292 (39%), Positives = 173/292 (59%), Gaps = 6/292 (2%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           M+ F+ +  +GEG YGVV K +++ET ++VA+KK +   E E V  T +RE+ +L+ LK 
Sbjct: 1   MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG-VPPEKVKSYIYQLIKAIHWCHK 128
            NIV L +      KLYLVFE++ +++ + ++  P   +P   +KSY++QL++ + +CH 
Sbjct: 61  PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120

Query: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP- 187
           + ++HRD+KP+NLLI+    +KL DFG AR         YT  V T WYR+PE+LLG+  
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLR-TYTHEVVTLWYRAPEILLGSKF 179

Query: 188 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 247
           Y  +VD+WS+GCI  E+   + LFPG+SEIDQLF I ++LG    +        P + G 
Sbjct: 180 YTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG- 238

Query: 248 RFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQT 299
            FP     + LE   +  L     DL+  LL+ DP+ R   +  L HP F +
Sbjct: 239 SFPKWTR-KGLE-EIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS 288


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  205 bits (522), Expect = 2e-52
 Identities = 118/291 (40%), Positives = 172/291 (59%), Gaps = 7/291 (2%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           M  +  +  +GEG YGVV K RHK T ++VA+KK +   E E V  T +RE+ +L+ L+ 
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNG--VPPEKVKSYIYQLIKAIHWCH 127
            NIV L++   +  +LYL+FE++  ++ + L+ +P G  +    VKSY+YQ+++ I +CH
Sbjct: 61  PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120

Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-A 186
              ++HRD+KP+NLLI     +KL DFG AR         YT    T WYRSPE+LLG A
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRV-YTHEAITLWYRSPEVLLGSA 179

Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 246
            Y   VD+WS+G I  EL+  +PLF G+SEIDQLF I + LG  P+ ++     + + + 
Sbjct: 180 RYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALG-TPNNEVWPEVESLQDYK 238

Query: 247 LRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
             FP    P SL   ++  L+   LDL+  +L  DPA R   +  LNHP F
Sbjct: 239 NTFPKWK-PGSL-ASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF 287


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score =  203 bits (516), Expect = 8e-52
 Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           + +F+ L  + EG YGVV + + K+T EIVA+K+ K  +E E    T+LRE+  +   + 
Sbjct: 410 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 469

Query: 70  ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
            NIV ++E        K+Y+V  YVE ++  L+E M     P +VK+ + QL++ +   H
Sbjct: 470 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 529

Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
            N I+HRD+K  NLL+SH  +LK+ DFG AR       A YT  V T+WYR+PELLLGA 
Sbjct: 530 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTQWYRAPELLLGAK 588

Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
            Y  +VDMWSVGCI GEL   +PLFPG SEIDQ+  + K LG  PSE++   YS  P   
Sbjct: 589 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELG-TPSEKIWPGYSELPVVK 647

Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
            + F    HP  +L +R+  +L+    DLM   L   P  R   E  L H  F +T   +
Sbjct: 648 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 705

Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
           D S  P+  AK +   V+  T     + G
Sbjct: 706 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 734


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score =  203 bits (516), Expect = 8e-52
 Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           + +F+ L  + EG YGVV + + K+T EIVA+K+ K  +E E    T+LRE+  +   + 
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479

Query: 70  ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
            NIV ++E        K+Y+V  YVE ++  L+E M     P +VK+ + QL++ +   H
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539

Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
            N I+HRD+K  NLL+SH  +LK+ DFG AR       A YT  V T+WYR+PELLLGA 
Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTQWYRAPELLLGAK 598

Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
            Y  +VDMWSVGCI GEL   +PLFPG SEIDQ+  + K LG  PSE++   YS  P   
Sbjct: 599 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELG-TPSEKIWPGYSELPVVK 657

Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
            + F    HP  +L +R+  +L+    DLM   L   P  R   E  L H  F +T   +
Sbjct: 658 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 715

Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
           D S  P+  AK +   V+  T     + G
Sbjct: 716 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 744


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score =  202 bits (515), Expect = 1e-51
 Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           + +F+ L  + EG YGVV + + K+T EIVA+K+ K  +E E    T+LRE+  +   + 
Sbjct: 411 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 470

Query: 70  ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
            NIV ++E        K+Y+V  YVE ++  L+E M     P +VK+ + QL++ +   H
Sbjct: 471 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 530

Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
            N I+HRD+K  NLL+SH  +LK+ DFG AR       A YT  V T WYR+PELLLGA 
Sbjct: 531 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 589

Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
            Y  +VDMWSVGCI GEL   +PLFPG+SEIDQ+  + K LG  PSE++   YS  P   
Sbjct: 590 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 648

Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
            + F    HP  +L +R+  +L+    DLM   L   P  R   E  L H  F +T   +
Sbjct: 649 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 706

Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
           D S  P+  AK +   V+  T     + G
Sbjct: 707 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 735


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score =  202 bits (515), Expect = 1e-51
 Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           + +F+ L  + EG YGVV + + K+T EIVA+K+ K  +E E    T+LRE+  +   + 
Sbjct: 420 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 479

Query: 70  ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
            NIV ++E        K+Y+V  YVE ++  L+E M     P +VK+ + QL++ +   H
Sbjct: 480 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 539

Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
            N I+HRD+K  NLL+SH  +LK+ DFG AR       A YT  V T WYR+PELLLGA 
Sbjct: 540 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 598

Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
            Y  +VDMWSVGCI GEL   +PLFPG+SEIDQ+  + K LG  PSE++   YS  P   
Sbjct: 599 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 657

Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
            + F    HP  +L +R+  +L+    DLM   L   P  R   E  L H  F +T   +
Sbjct: 658 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 715

Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
           D S  P+  AK +   V+  T     + G
Sbjct: 716 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 744


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score =  202 bits (515), Expect = 1e-51
 Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           + +F+ L  + EG YGVV + + K+T EIVA+K+ K  +E E    T+LRE+  +   + 
Sbjct: 388 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 447

Query: 70  ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
            NIV ++E        K+Y+V  YVE ++  L+E M     P +VK+ + QL++ +   H
Sbjct: 448 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 507

Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
            N I+HRD+K  NLL+SH  +LK+ DFG AR       A YT  V T WYR+PELLLGA 
Sbjct: 508 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 566

Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
            Y  +VDMWSVGCI GEL   +PLFPG+SEIDQ+  + K LG  PSE++   YS  P   
Sbjct: 567 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 625

Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
            + F    HP  +L +R+  +L+    DLM   L   P  R   E  L H  F +T   +
Sbjct: 626 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 683

Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
           D S  P+  AK +   V+  T     + G
Sbjct: 684 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 712


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score =  202 bits (515), Expect = 1e-51
 Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           + +F+ L  + EG YGVV + + K+T EIVA+K+ K  +E E    T+LRE+  +   + 
Sbjct: 377 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 436

Query: 70  ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
            NIV ++E        K+Y+V  YVE ++  L+E M     P +VK+ + QL++ +   H
Sbjct: 437 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 496

Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
            N I+HRD+K  NLL+SH  +LK+ DFG AR       A YT  V T WYR+PELLLGA 
Sbjct: 497 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 555

Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
            Y  +VDMWSVGCI GEL   +PLFPG+SEIDQ+  + K LG  PSE++   YS  P   
Sbjct: 556 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 614

Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
            + F    HP  +L +R+  +L+    DLM   L   P  R   E  L H  F +T   +
Sbjct: 615 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 672

Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
           D S  P+  AK +   V+  T     + G
Sbjct: 673 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 701


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score =  202 bits (515), Expect = 1e-51
 Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           + +F+ L  + EG YGVV + + K+T EIVA+K+ K  +E E    T+LRE+  +   + 
Sbjct: 166 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 225

Query: 70  ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
            NIV ++E        K+Y+V  YVE ++  L+E M     P +VK+ + QL++ +   H
Sbjct: 226 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 285

Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
            N I+HRD+K  NLL+SH  +LK+ DFG AR       A YT  V T WYR+PELLLGA 
Sbjct: 286 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 344

Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
            Y  +VDMWSVGCI GEL   +PLFPG+SEIDQ+  + K LG  PSE++   YS  P   
Sbjct: 345 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 403

Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
            + F    HP  +L +R+  +L+    DLM   L   P  R   E  L H  F +T   +
Sbjct: 404 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 461

Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
           D S  P+  AK +   V+  T     + G
Sbjct: 462 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 490


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score =  202 bits (515), Expect = 1e-51
 Identities = 131/329 (39%), Positives = 183/329 (55%), Gaps = 12/329 (3%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           + +F+ L  + EG YGVV + + K+T EIVA+K+ K  +E E    T+LRE+  +   + 
Sbjct: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481

Query: 70  ENIVELKEAF--RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCH 127
            NIV ++E        K+Y+V  YVE ++  L+E M     P +VK+ + QL++ +   H
Sbjct: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 541

Query: 128 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA- 186
            N I+HRD+K  NLL+SH  +LK+ DFG AR       A YT  V T WYR+PELLLGA 
Sbjct: 542 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-YTPVVVTLWYRAPELLLGAK 600

Query: 187 PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSN-PRFH 245
            Y  +VDMWSVGCI GEL   +PLFPG+SEIDQ+  + K LG  PSE++   YS  P   
Sbjct: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLG-TPSEKIWPGYSELPAVK 659

Query: 246 GLRFPAVNHP-QSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF-QTQRLL 303
            + F    HP  +L +R+  +L+    DLM   L   P  R   E  L H  F +T   +
Sbjct: 660 KMTFS--EHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 717

Query: 304 DRS--PSRSAKRKPYHVESSTLSNRNQAG 330
           D S  P+  AK +   V+  T     + G
Sbjct: 718 DPSMFPTWPAKSEQQRVKRGTSPRPPEGG 746


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  200 bits (508), Expect = 7e-51
 Identities = 114/298 (38%), Positives = 166/298 (55%), Gaps = 20/298 (6%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           M  F+ +  +GEG YGVV K R+K T E+VA+KK +   E E V  T +RE+ +L+ L  
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAIHWCHK 128
            NIV+L +      KLYLVFE++ +++ + ++     G+P   +KSY++QL++ + +CH 
Sbjct: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120

Query: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP- 187
           + ++HRD+KP+NLLI+    +KL DFG AR         YT  V T WYR+PE+LLG   
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVR-TYTHEVVTLWYRAPEILLGCKY 179

Query: 188 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-------PLPSEQMKLFYS 240
           Y  +VD+WS+GCI  E+   + LFPG+SEIDQLF I + LG       P  +       S
Sbjct: 180 YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS 239

Query: 241 NPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 298
            P++    F  V  P   + R           L+  +L  DP  R   +  L HP FQ
Sbjct: 240 FPKWARQDFSKVVPPLDEDGR----------SLLSQMLHYDPNKRISAKAALAHPFFQ 287


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  199 bits (505), Expect = 1e-50
 Identities = 118/315 (37%), Positives = 181/315 (57%), Gaps = 26/315 (8%)

Query: 10   MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
            ++KF+I+G++GEG YG V K R K+T E+VA+KK +   E E    T +RE+K+LR L  
Sbjct: 702  VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761

Query: 70   ENIVELKEAF----------RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQL 119
            ++I+ +KE            + +G  YLVFEY++ +++ LLE          +KS++ QL
Sbjct: 762  QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 821

Query: 120  IKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRS 179
            ++ + +CHK + +HRDIK  N+L+++   +KL DFG AR  S   +  YT  V T WYR 
Sbjct: 822  MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRP 881

Query: 180  PELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPS---EQ 234
            PELLLG   Y  ++D+WS GCILGEL   +P+F    E+ QL  I ++ G P P+   + 
Sbjct: 882  PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDV 941

Query: 235  MKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
            +KL    P F+ ++ P   + + L   ++  + +  LDL   +L LDP+ R   EQ L  
Sbjct: 942  IKL----PYFNTMK-PKKQYRRKLREEFV-FIPAAALDLFDYMLALDPSKRCTAEQAL-- 993

Query: 295  PTFQTQRLLDRSPSR 309
               Q + L D  PS+
Sbjct: 994  ---QCEFLRDVEPSK 1005



 Score = 31.6 bits (70), Expect = 4.0
 Identities = 83/399 (20%), Positives = 140/399 (35%), Gaps = 74/399 (18%)

Query: 543 SPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPF 602
           S SG   R EG+    R   R S    + +  EH         S   +S S         
Sbjct: 183 SSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRS--------- 233

Query: 603 SSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARS 662
                  RHS         AK    S S G+  +A A S    S +  +      + A  
Sbjct: 234 -------RHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRD------SKAHR 280

Query: 663 SVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYN---------DPVPRRVG 713
           S  ++S+E  S++    K+        + +D T PK  R   +          PV  R  
Sbjct: 281 SRTKSSKEPPSAYKEPPKA--------YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRAS 332

Query: 714 SFYRV---PSPRPDNSFHENNVSTRVSSLPS-----ESSSGTNHSKRQPAFDPWKSPENI 765
              R    PSP    S   +  S R+   PS      S S + HS  +   D   SP + 
Sbjct: 333 QSLRSRKSPSPAGGGS---SPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSS 389

Query: 766 SHSEQLKEKEKQGFFRSMKKKKK-----------------KSQTVPNSDSPDLLTLQKSI 808
           S   + +        RS K + +                 +S++  +S SP  LTL+ S+
Sbjct: 390 SSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSL 449

Query: 809 HSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTK 868
            +    + + +     + ++    ++  K+       + ASN    +    +   +    
Sbjct: 450 AAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQT 509

Query: 869 NSFSEIR----IHPLSQASGGSSNIRQEPAPKGRPALQL 903
           N   +++     H  S +SGG+  ++ + A K +P LQ+
Sbjct: 510 NHVKDVKKIKIEHAPSPSSGGT--LKNDKA-KTKPPLQV 545



 Score = 31.6 bits (70), Expect = 4.0
 Identities = 53/244 (21%), Positives = 83/244 (34%), Gaps = 14/244 (5%)

Query: 326 RNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQ 385
           R+ +G+S      HR              R+       E         +S S    K+  
Sbjct: 203 RSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSAS 262

Query: 386 ASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYL--KSNSRSQQN 443
           A+S   S+ KD   ++  H    K +K          P   + P   Y   K+  ++ + 
Sbjct: 263 ATSSSSSSRKD--RDSKAHRSRTKSSKEP--------PSAYKEPPKAYREDKTEPKAYRR 312

Query: 444 RHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSY-RTKAKSHGALSDSKSVS-NL 501
           R S           +     QS  S     P    S  Y R   +S    S  +S S + 
Sbjct: 313 RRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSR 372

Query: 502 SEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTT 561
             +  +  + S S Y  SS     SP SP   R   +R+    S R++R+       R+ 
Sbjct: 373 HSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSR 432

Query: 562 TRHS 565
           +RHS
Sbjct: 433 SRHS 436


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score =  199 bits (505), Expect = 1e-50
 Identities = 118/315 (37%), Positives = 181/315 (57%), Gaps = 26/315 (8%)

Query: 10   MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
            ++KF+I+G++GEG YG V K R K+T E+VA+KK +   E E    T +RE+K+LR L  
Sbjct: 702  VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761

Query: 70   ENIVELKEAF----------RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQL 119
            ++I+ +KE            + +G  YLVFEY++ +++ LLE          +KS++ QL
Sbjct: 762  QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 821

Query: 120  IKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRS 179
            ++ + +CHK + +HRDIK  N+L+++   +KL DFG AR  S   +  YT  V T WYR 
Sbjct: 822  MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRP 881

Query: 180  PELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPS---EQ 234
            PELLLG   Y  ++D+WS GCILGEL   +P+F    E+ QL  I ++ G P P+   + 
Sbjct: 882  PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDV 941

Query: 235  MKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
            +KL    P F+ ++ P   + + L   ++  + +  LDL   +L LDP+ R   EQ L  
Sbjct: 942  IKL----PYFNTMK-PKKQYRRKLREEFV-FIPAAALDLFDYMLALDPSKRCTAEQAL-- 993

Query: 295  PTFQTQRLLDRSPSR 309
               Q + L D  PS+
Sbjct: 994  ---QCEFLRDVEPSK 1005



 Score = 31.6 bits (70), Expect = 4.0
 Identities = 83/399 (20%), Positives = 140/399 (35%), Gaps = 74/399 (18%)

Query: 543 SPSGRNNRNEGTLDSRRTTTRHSKTMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPF 602
           S SG   R EG+    R   R S    + +  EH         S   +S S         
Sbjct: 183 SSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRS--------- 233

Query: 603 SSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARS 662
                  RHS         AK    S S G+  +A A S    S +  +      + A  
Sbjct: 234 -------RHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRD------SKAHR 280

Query: 663 SVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPKENRHLYN---------DPVPRRVG 713
           S  ++S+E  S++    K+        + +D T PK  R   +          PV  R  
Sbjct: 281 SRTKSSKEPPSAYKEPPKA--------YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRAS 332

Query: 714 SFYRV---PSPRPDNSFHENNVSTRVSSLPS-----ESSSGTNHSKRQPAFDPWKSPENI 765
              R    PSP    S   +  S R+   PS      S S + HS  +   D   SP + 
Sbjct: 333 QSLRSRKSPSPAGGGS---SPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSS 389

Query: 766 SHSEQLKEKEKQGFFRSMKKKKK-----------------KSQTVPNSDSPDLLTLQKSI 808
           S   + +        RS K + +                 +S++  +S SP  LTL+ S+
Sbjct: 390 SSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSL 449

Query: 809 HSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQQTK 868
            +    + + +     + ++    ++  K+       + ASN    +    +   +    
Sbjct: 450 AAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQT 509

Query: 869 NSFSEIR----IHPLSQASGGSSNIRQEPAPKGRPALQL 903
           N   +++     H  S +SGG+  ++ + A K +P LQ+
Sbjct: 510 NHVKDVKKIKIEHAPSPSSGGT--LKNDKA-KTKPPLQV 545



 Score = 31.6 bits (70), Expect = 4.0
 Identities = 53/244 (21%), Positives = 83/244 (34%), Gaps = 14/244 (5%)

Query: 326 RNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQ 385
           R+ +G+S      HR              R+       E         +S S    K+  
Sbjct: 203 RSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSAS 262

Query: 386 ASSQPGSTSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYL--KSNSRSQQN 443
           A+S   S+ KD   ++  H    K +K          P   + P   Y   K+  ++ + 
Sbjct: 263 ATSSSSSSRKD--RDSKAHRSRTKSSKEP--------PSAYKEPPKAYREDKTEPKAYRR 312

Query: 444 RHSFMESSQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSY-RTKAKSHGALSDSKSVS-NL 501
           R S           +     QS  S     P    S  Y R   +S    S  +S S + 
Sbjct: 313 RRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSR 372

Query: 502 SEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTT 561
             +  +  + S S Y  SS     SP SP   R   +R+    S R++R+       R+ 
Sbjct: 373 HSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSR 432

Query: 562 TRHS 565
           +RHS
Sbjct: 433 SRHS 436


>gi|27477122 intestinal cell kinase [Homo sapiens]
          Length = 632

 Score =  196 bits (499), Expect = 7e-50
 Identities = 160/572 (27%), Positives = 261/572 (45%), Gaps = 76/572 (13%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           MN++  +  +G+G YG VL  R  E+ E++AIKK K    + E +   LRE+K L+ L  
Sbjct: 1   MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWE-ECMNLREVKSLKKLNH 59

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
            N+V+LKE  R    LY +FEY+++N+ +L++E     P   +++ +YQ+++ + + HK+
Sbjct: 60  ANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKH 119

Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
              HRD+KPENLL    +++K+ DFG AR +   +   YT+YV+TRWYR+PE+LL    Y
Sbjct: 120 GFFHRDLKPENLLCMGPELVKIADFGLAREIR--SKPPYTDYVSTRWYRAPEVLLRSTNY 177

Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
              +D+W+VGCI+ E+   +PLFPG SEID +F I +VLG          Y        R
Sbjct: 178 SSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFR 237

Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ--------TQ 300
           +P    P +L +  +   +S  + L++++L+ DP  R    Q L +P FQ        TQ
Sbjct: 238 WPQC-VPNNL-KTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQ 295

Query: 301 RLLD-RSPSRSAKRK---------------PYHVESSTLSNRNQAG----------KSTA 334
            L D   P +    K               P    +   S ++QA           K+  
Sbjct: 296 NLQDSEKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPPLHLTYPYKAEV 355

Query: 335 LQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTY---QASSQPG 391
            ++ H S+ ++ +   +  P      P ++           + P   + +     S++  
Sbjct: 356 SRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKDS 415

Query: 392 STSKDLTNNNIPHLLSPKEAKSK--------TEFDFNIDPKPSEGPGTKYLKSNSRSQQN 443
               DL + +    LS  + K+K          F+  +D KPSE  GT     NS   Q 
Sbjct: 416 DDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCRFESVLDLKPSEPVGT----GNSAPTQT 471

Query: 444 RHSFMESSQSKAGTLQPNEKQSRH----------------SYIDTIPQSSRSPSYRTKAK 487
            +   ++   ++   Q   K SR+                 +I   P SS   S     K
Sbjct: 472 SYQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLS----GK 527

Query: 488 SHGALSDSKSVSNLSEARAQIAEPSTSRYFPS 519
           S G +S    V+++  +    +   T  Y PS
Sbjct: 528 SSGTMSVISKVNSVGSSSTS-SSGLTGNYVPS 558


>gi|7662388 intestinal cell kinase [Homo sapiens]
          Length = 632

 Score =  196 bits (499), Expect = 7e-50
 Identities = 160/572 (27%), Positives = 261/572 (45%), Gaps = 76/572 (13%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           MN++  +  +G+G YG VL  R  E+ E++AIKK K    + E +   LRE+K L+ L  
Sbjct: 1   MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWE-ECMNLREVKSLKKLNH 59

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
            N+V+LKE  R    LY +FEY+++N+ +L++E     P   +++ +YQ+++ + + HK+
Sbjct: 60  ANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKH 119

Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
              HRD+KPENLL    +++K+ DFG AR +   +   YT+YV+TRWYR+PE+LL    Y
Sbjct: 120 GFFHRDLKPENLLCMGPELVKIADFGLAREIR--SKPPYTDYVSTRWYRAPEVLLRSTNY 177

Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
              +D+W+VGCI+ E+   +PLFPG SEID +F I +VLG          Y        R
Sbjct: 178 SSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFR 237

Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ--------TQ 300
           +P    P +L +  +   +S  + L++++L+ DP  R    Q L +P FQ        TQ
Sbjct: 238 WPQC-VPNNL-KTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLGSTTQ 295

Query: 301 RLLD-RSPSRSAKRK---------------PYHVESSTLSNRNQAG----------KSTA 334
            L D   P +    K               P    +   S ++QA           K+  
Sbjct: 296 NLQDSEKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRISSRQHQASQPPLHLTYPYKAEV 355

Query: 335 LQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTY---QASSQPG 391
            ++ H S+ ++ +   +  P      P ++           + P   + +     S++  
Sbjct: 356 SRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEHKNGEIKPKSRRRWGLISRSTKDS 415

Query: 392 STSKDLTNNNIPHLLSPKEAKSK--------TEFDFNIDPKPSEGPGTKYLKSNSRSQQN 443
               DL + +    LS  + K+K          F+  +D KPSE  GT     NS   Q 
Sbjct: 416 DDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCRFESVLDLKPSEPVGT----GNSAPTQT 471

Query: 444 RHSFMESSQSKAGTLQPNEKQSRH----------------SYIDTIPQSSRSPSYRTKAK 487
            +   ++   ++   Q   K SR+                 +I   P SS   S     K
Sbjct: 472 SYQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSNPGKEFIPPNPWSSSGLS----GK 527

Query: 488 SHGALSDSKSVSNLSEARAQIAEPSTSRYFPS 519
           S G +S    V+++  +    +   T  Y PS
Sbjct: 528 SSGTMSVISKVNSVGSSSTS-SSGLTGNYVPS 558


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  196 bits (499), Expect = 7e-50
 Identities = 115/313 (36%), Positives = 180/313 (57%), Gaps = 21/313 (6%)

Query: 10   MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
            ++KF+I+G++GEG YG V K + K+T E+VA+KK +   E E    T +RE+K+LR L  
Sbjct: 724  VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783

Query: 70   ENIVELKEAF----------RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQL 119
             ++V +KE            + +G  YLVFEY++ +++ LLE        + +KS++ QL
Sbjct: 784  RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 843

Query: 120  IKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRS 179
            ++ + +CHK + +HRDIK  N+L++++  +KL DFG AR  +   +  YT  V T WYR 
Sbjct: 844  MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 903

Query: 180  PELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPS---EQ 234
            PELLLG   Y  ++D+WS GCILGEL   +P+F    E+ QL  I ++ G P P+   + 
Sbjct: 904  PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDV 963

Query: 235  MKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
            +KL    P F+ ++ P   + + L R     + S  LDL+ ++L LDP+ R   EQ L  
Sbjct: 964  IKL----PYFNTMK-PKKQYRRRL-REEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQS 1017

Query: 295  PTFQTQRLLDRSP 307
               +   L   +P
Sbjct: 1018 DFLKDVELSKMAP 1030



 Score = 37.7 bits (86), Expect = 0.056
 Identities = 75/339 (22%), Positives = 114/339 (33%), Gaps = 25/339 (7%)

Query: 485 KAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSP 544
           K KS    S S S+ +     ++ +   T  Y  +     +S  S +   H +       
Sbjct: 130 KEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE 189

Query: 545 SGRNNRNEGTLDSRRTTTRHSKTMEELKLPE---HMDSSHSHSLSAPHESFSYGLGYTSP 601
               +++      +R T +  KT++  K      H   S S          SYG  Y   
Sbjct: 190 LKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDL- 248

Query: 602 FSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVAR 661
             S  R H  S Y +  K       GS S  Q ++           Q   + P   +  +
Sbjct: 249 --SPSRSHTSSNYDSYKKS-----PGSTSRRQSVSPPYKEPSAY--QSSTRSPSPYSRRQ 299

Query: 662 SSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPK--ENRHLYNDPVPRRVGSFYRVP 719
            SV   SR  +SS+  R  S  G    P+    ++      R L   P+P R     R  
Sbjct: 300 RSVSPYSRRRSSSYE-RSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSR 358

Query: 720 SPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGF 779
           SP    S H ++ S +       SSS + HS   P   P  S      S + KE+     
Sbjct: 359 SPA--YSRHSSSHSKK-----KRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAA 411

Query: 780 FRSMKKKKKKSQTV--PNSDSPDLLTLQKSIHSASTPSS 816
              M  K+ K   V  P  ++  +      + S   P S
Sbjct: 412 AAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS 450


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  196 bits (499), Expect = 7e-50
 Identities = 115/313 (36%), Positives = 180/313 (57%), Gaps = 21/313 (6%)

Query: 10   MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
            ++KF+I+G++GEG YG V K + K+T E+VA+KK +   E E    T +RE+K+LR L  
Sbjct: 724  VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783

Query: 70   ENIVELKEAF----------RRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQL 119
             ++V +KE            + +G  YLVFEY++ +++ LLE        + +KS++ QL
Sbjct: 784  RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 843

Query: 120  IKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRS 179
            ++ + +CHK + +HRDIK  N+L++++  +KL DFG AR  +   +  YT  V T WYR 
Sbjct: 844  MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 903

Query: 180  PELLLGAP-YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG-PLPS---EQ 234
            PELLLG   Y  ++D+WS GCILGEL   +P+F    E+ QL  I ++ G P P+   + 
Sbjct: 904  PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDV 963

Query: 235  MKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNH 294
            +KL    P F+ ++ P   + + L R     + S  LDL+ ++L LDP+ R   EQ L  
Sbjct: 964  IKL----PYFNTMK-PKKQYRRRL-REEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQS 1017

Query: 295  PTFQTQRLLDRSP 307
               +   L   +P
Sbjct: 1018 DFLKDVELSKMAP 1030



 Score = 37.7 bits (86), Expect = 0.056
 Identities = 75/339 (22%), Positives = 114/339 (33%), Gaps = 25/339 (7%)

Query: 485 KAKSHGALSDSKSVSNLSEARAQIAEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSP 544
           K KS    S S S+ +     ++ +   T  Y  +     +S  S +   H +       
Sbjct: 130 KEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKERE 189

Query: 545 SGRNNRNEGTLDSRRTTTRHSKTMEELKLPE---HMDSSHSHSLSAPHESFSYGLGYTSP 601
               +++      +R T +  KT++  K      H   S S          SYG  Y   
Sbjct: 190 LKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDL- 248

Query: 602 FSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVAR 661
             S  R H  S Y +  K       GS S  Q ++           Q   + P   +  +
Sbjct: 249 --SPSRSHTSSNYDSYKKS-----PGSTSRRQSVSPPYKEPSAY--QSSTRSPSPYSRRQ 299

Query: 662 SSVKETSREGTSSFHTRQKSEGGVYHDPHSDDGTAPK--ENRHLYNDPVPRRVGSFYRVP 719
            SV   SR  +SS+  R  S  G    P+    ++      R L   P+P R     R  
Sbjct: 300 RSVSPYSRRRSSSYE-RSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSR 358

Query: 720 SPRPDNSFHENNVSTRVSSLPSESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGF 779
           SP    S H ++ S +       SSS + HS   P   P  S      S + KE+     
Sbjct: 359 SPA--YSRHSSSHSKK-----KRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAA 411

Query: 780 FRSMKKKKKKSQTV--PNSDSPDLLTLQKSIHSASTPSS 816
              M  K+ K   V  P  ++  +      + S   P S
Sbjct: 412 AAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS 450


>gi|11496279 male germ cell-associated kinase [Homo sapiens]
          Length = 623

 Score =  196 bits (498), Expect = 9e-50
 Identities = 110/318 (34%), Positives = 179/318 (56%), Gaps = 6/318 (1%)

Query: 10  MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
           MN++  +  +G+G YG VL  +  E+ E+VAIK+ K    + + +   LRE+K L+ L  
Sbjct: 1   MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWD-ECMNLREVKSLKKLNH 59

Query: 70  ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
            N+++LKE  R    LY +FEY+++N+ +L+++     P   +++ +YQ+++ + + HK+
Sbjct: 60  ANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKH 119

Query: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLL-GAPY 188
              HRD+KPENLL    +++K+ DFG AR L   +   YT+YV+TRWYR+PE+LL  + Y
Sbjct: 120 GFFHRDMKPENLLCMGPELVKIADFGLARELR--SQPPYTDYVSTRWYRAPEVLLRSSVY 177

Query: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
              +D+W+VG I+ EL   +PLFPG SE+D++F I +VLG          Y        R
Sbjct: 178 SSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFR 237

Query: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
           FP    P +L+       N   + LM  +L  DP  R    Q L HP FQ  ++L  S +
Sbjct: 238 FPQC-VPINLKTLIPNASNEA-IQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSN 295

Query: 309 RSAKRKPYHVESSTLSNR 326
               ++  + +   L ++
Sbjct: 296 HLESKQSLNKQLQPLESK 313


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  194 bits (494), Expect = 3e-49
 Identities = 112/294 (38%), Positives = 164/294 (55%), Gaps = 11/294 (3%)

Query: 12  KFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFK---DSEENEEVKETTLRELKMLRTLK 68
           ++E L  +GEG +  V K R K T++IVAIKK K    SE  + +  T LRE+K+L+ L 
Sbjct: 11  RYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELS 70

Query: 69  QENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHK 128
             NI+ L +AF  +  + LVF+++E ++  ++++    + P  +K+Y+   ++ + + H+
Sbjct: 71  HPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 130

Query: 129 NDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAP- 187
           + I+HRD+KP NLL+  N VLKL DFG A++    N A YT  V TRWYR+PELL GA  
Sbjct: 131 HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA-YTHQVVTRWYRAPELLFGARM 189

Query: 188 YGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGL 247
           YG  VDMW+VGCIL EL    P  PG+S++DQL  I + LG    EQ     S P +   
Sbjct: 190 YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTF 249

Query: 248 R-FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQ 300
           + FP +                 LLDL++ L   +P  R    Q L    F  +
Sbjct: 250 KSFPGIP-----LHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNR 298


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  184 bits (468), Expect = 3e-46
 Identities = 104/283 (36%), Positives = 156/283 (55%), Gaps = 5/283 (1%)

Query: 16  LGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVEL 75
           L  +GEG Y  V K + K T  +VA+K+ +  E  E    T +RE+ +L+ LK  NIV L
Sbjct: 174 LDKLGEGTYATVYKGKSKLTDNLVALKEIR-LEHEEGAPCTAIREVSLLKDLKHANIVTL 232

Query: 76  KEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRD 135
            +       L LVFEY++K++ + L++  N +    VK +++QL++ + +CH+  ++HRD
Sbjct: 233 HDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRD 292

Query: 136 IKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGA-PYGKSVDM 194
           +KP+NLLI+    LKL DFG AR  S      Y+  V T WYR P++LLG+  Y   +DM
Sbjct: 293 LKPQNLLINERGELKLADFGLARAKSIPTK-TYSNEVVTLWYRPPDILLGSTDYSTQIDM 351

Query: 195 WSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH 254
           W VGCI  E++ G+PLFPG +  +QL  I ++LG    E      SN  F    +P    
Sbjct: 352 WGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRA 411

Query: 255 PQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
              L   +   L+S   DL+  LL+ +  +R   E  + HP F
Sbjct: 412 EALLS--HAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.128    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,496,906
Number of Sequences: 37866
Number of extensions: 2274438
Number of successful extensions: 10156
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 714
Number of HSP's successfully gapped in prelim test: 340
Number of HSP's that attempted gapping in prelim test: 7153
Number of HSP's gapped (non-prelim): 1849
length of query: 1030
length of database: 18,247,518
effective HSP length: 112
effective length of query: 918
effective length of database: 14,006,526
effective search space: 12857990868
effective search space used: 12857990868
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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