BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4507271 serine/threonine protein kinase 11 [Homo sapiens] (433 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4507271 serine/threonine protein kinase 11 [Homo sapiens] 885 0.0 gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 169 3e-42 gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 167 1e-41 gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub... 164 1e-40 gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 164 1e-40 gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 162 4e-40 gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 156 4e-38 gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 152 6e-37 gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 152 6e-37 gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 152 6e-37 gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 152 6e-37 gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 152 6e-37 gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 149 4e-36 gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 149 4e-36 gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 149 4e-36 gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 149 4e-36 gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 147 2e-35 gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2... 146 3e-35 gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2... 146 3e-35 gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2... 146 3e-35 gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2... 146 3e-35 gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 145 5e-35 gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 144 1e-34 gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ... 142 6e-34 gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha ... 142 6e-34 gi|116256471 SNF1-like kinase [Homo sapiens] 141 1e-33 gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2... 140 2e-33 gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2... 140 2e-33 gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2... 140 2e-33 gi|41872374 polo-like kinase 3 [Homo sapiens] 140 2e-33 >gi|4507271 serine/threonine protein kinase 11 [Homo sapiens] Length = 433 Score = 885 bits (2287), Expect = 0.0 Identities = 433/433 (100%), Positives = 433/433 (100%) Query: 1 MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSY 60 MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSY Sbjct: 1 MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSY 60 Query: 61 GKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE 120 GKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE Sbjct: 61 GKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE 120 Query: 121 EKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG 180 EKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG Sbjct: 121 EKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG 180 Query: 181 NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWS 240 NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWS Sbjct: 181 NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWS 240 Query: 241 AGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI 300 AGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI Sbjct: 241 AGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI 300 Query: 301 RQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDI 360 RQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDI Sbjct: 301 RQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDI 360 Query: 361 IYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA 420 IYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA Sbjct: 361 IYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA 420 Query: 421 SSKIRRLSACKQQ 433 SSKIRRLSACKQQ Sbjct: 421 SSKIRRLSACKQQ 433 >gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 1 [Homo sapiens] Length = 559 Score = 169 bits (429), Expect = 3e-42 Identities = 99/270 (36%), Positives = 159/270 (58%), Gaps = 10/270 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y++GD LG G++GKVK T + AVKIL ++K+R + + +++EIQ L+ Sbjct: 24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSL-DVVGKIRREIQNLKLF 82 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLIDGL 164 RH ++I+L V+ ++MVMEY G E+ D + + R ++ F Q++ G+ Sbjct: 83 RHPHIIKLYQVI--STPSDIFMVMEYVSGG--ELFDYICKNGRLDEKESRRLFQQILSGV 138 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H +VH+D+KP N+LL KI+D G++ + + + RTS GSP + PE+ Sbjct: 139 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEV 195 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 +G ++G +VDIWS+GV LY + G PF+ D++ LF+ I G + P P + Sbjct: 196 ISGR-LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS 254 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 314 LLK ML+ +P KR +I+ IR+H WF++ P Sbjct: 255 LLKHMLQVDPMKRATIKDIREHEWFKQDLP 284 >gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] Length = 668 Score = 167 bits (424), Expect = 1e-41 Identities = 121/410 (29%), Positives = 203/410 (49%), Gaps = 53/410 (12%) Query: 41 KRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQ 100 + A+ +G Y + LG+G G VK + T + A+KI+ ++KL + V++EI Sbjct: 11 QHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSE--SVLMKVEREIA 68 Query: 101 LLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQ 159 +L+ + H +V++L DV E K+ +Y+V+E+ G E+ D + +K R +A +F Q Sbjct: 69 ILKLIEHPHVLKLHDVY--ENKKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQ 124 Query: 160 LIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAF 219 +I L++ HS I H+D+KP NLLL ++I+D G+A D TS GSP + Sbjct: 125 IISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQ---VGDSLLETSCGSPHY 181 Query: 220 QPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCG 279 PE+ G + + G K D+WS GV L+ + G PF+ DN+ +L E + +G + +P Sbjct: 182 ACPEVIRG-EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP 240 Query: 280 PPLSDLLKGMLEYEPAKRFSIRQIRQHSWF--RKKHPPAEAPVP-------IPP----SP 326 P LL+GM+E + A+R ++ I++H W+ K P E P+P +P P Sbjct: 241 PDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDP 300 Query: 327 DTKDRWRSMTVV----PYLEDLHGADEDED------LFDIEDDIIYTQDFTVP------- 369 D D S+ L+DL +E+++ L D ++ +D +P Sbjct: 301 DVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDP 360 Query: 370 --GQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKA 417 +V + +G+RR E + S +G +P PAR+A Sbjct: 361 PRKRVDSPMLNRHGKRR----------PERKSMEVLSVTDGGSPVPARRA 400 >gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic subunit isoform 2 [Homo sapiens] Length = 574 Score = 164 bits (416), Expect = 1e-40 Identities = 99/283 (34%), Positives = 159/283 (56%), Gaps = 21/283 (7%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y++GD LG G++GKVK T + AVKIL ++K+R + + +++EIQ L+ Sbjct: 24 IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSL-DVVGKIRREIQNLKLF 82 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEY----------CVCGMQEMLDSVPE----KRFPVC 151 RH ++I+L V+ ++MVMEY C G + + V + K Sbjct: 83 RHPHIIKLYQVI--STPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEK 140 Query: 152 QAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCR 211 ++ F Q++ G++Y H +VH+D+KP N+LL KI+D G++ + + + R Sbjct: 141 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLR 197 Query: 212 TSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGS 271 TS GSP + PE+ +G ++G +VDIWS+GV LY + G PF+ D++ LF+ I G Sbjct: 198 TSCGSPNYAAPEVISGR-LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI 256 Query: 272 YAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 314 + P P + LLK ML+ +P KR +I+ IR+H WF++ P Sbjct: 257 FYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP 299 >gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] Length = 778 Score = 164 bits (416), Expect = 1e-40 Identities = 98/285 (34%), Positives = 159/285 (55%), Gaps = 12/285 (4%) Query: 41 KRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQ 100 + A+ +G Y + LG+G G VK + T + A+KI+ ++KL + V++EI Sbjct: 26 QHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSE--SVLMKVEREIA 83 Query: 101 LLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQ 159 +L+ + H +V++L DV E K+ +Y+V+E+ G E+ D + +K R +A +F Q Sbjct: 84 ILKLIEHPHVLKLHDVY--ENKKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQ 139 Query: 160 LIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAF 219 ++ L++ HS I H+D+KP NLLL ++I+D G+A D TS GSP + Sbjct: 140 IVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQ---VGDSLLETSCGSPHY 196 Query: 220 QPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCG 279 PE+ G + + G + D+WS GV L+ + G PF+ DN+ +L E + +G + +P Sbjct: 197 ACPEVIKG-EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP 255 Query: 280 PPLSDLLKGMLEYEPAKRFSIRQIRQHSWF-RKKHPPAEAPVPIP 323 P LL+GM+E EP KR S+ QI++H W+ KH P P P Sbjct: 256 PDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAP 300 >gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit [Homo sapiens] Length = 552 Score = 162 bits (411), Expect = 4e-40 Identities = 98/270 (36%), Positives = 156/270 (57%), Gaps = 10/270 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y++GD LG G++GKVK T + AVKIL ++K+R + + +K+EIQ L+ Sbjct: 13 IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSL-DVVGKIKREIQNLKLF 71 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLIDGL 164 RH ++I+L V+ +MVMEY G E+ D + + R +A F Q++ + Sbjct: 72 RHPHIIKLYQVI--STPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAV 127 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H +VH+D+KP N+LL KI+D G++ + + + RTS GSP + PE+ Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEV 184 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 +G ++G +VDIWS GV LY + G PF+ +++ LF+ I G + IP ++ Sbjct: 185 ISGR-LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 314 LL ML+ +P KR +I+ IR+H WF++ P Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLP 273 >gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo sapiens] Length = 795 Score = 156 bits (394), Expect = 4e-38 Identities = 115/386 (29%), Positives = 187/386 (48%), Gaps = 22/386 (5%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y + +G+G++ KVK T AVKI+ K +L P + +E+++++ L Sbjct: 57 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN--PTSLQKLFREVRIMKIL 114 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y+VMEY G E+ D V R +A F Q++ + Sbjct: 115 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 170 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H + IVH+D+K NLLL +KI+D G + + F + T GSP + PE+ Sbjct: 171 QYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFS---NEFTVGNKLDTFCGSPPYAAPEL 227 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VD+WS GV LY + +G PF+G N+ +L E + +G Y IP + Sbjct: 228 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 286 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWR--SMTVVPYLE 342 LLK +L P KR S+ QI + W H E P PD D R M + + Sbjct: 287 LLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFAR 346 Query: 343 DLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLST 402 D + ++ L + + D + + + PE E + L C ++ L+ Sbjct: 347 D----EINDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNL----CQRSRPSSDLN- 397 Query: 403 KSRAEGRAPNPARKACSASSKIRRLS 428 S + A +++ SA+ K RR S Sbjct: 398 NSTLQSPAHLKVQRSISANQKQRRFS 423 >gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f [Homo sapiens] Length = 709 Score = 152 bits (384), Expect = 6e-37 Identities = 97/294 (32%), Positives = 155/294 (52%), Gaps = 11/294 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y + +G+G++ KVK T AVKI+ K +L + + +E+++++ L Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS--SSLQKLFREVRIMKVL 107 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y+VMEY G E+ D V R +A F Q++ + Sbjct: 108 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 163 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H + IVH+D+K NLLL +KI+D G + + F + T GSP + PE+ Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPYAAPEL 220 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VD+WS GV LY + +G PF+G N+ +L E + +G Y IP + Sbjct: 221 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 279 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338 LLK L P+KR ++ QI + W H E + P PD KD R+ +V Sbjct: 280 LLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333 >gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e [Homo sapiens] Length = 719 Score = 152 bits (384), Expect = 6e-37 Identities = 97/294 (32%), Positives = 155/294 (52%), Gaps = 11/294 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y + +G+G++ KVK T AVKI+ K +L + + +E+++++ L Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS--SSLQKLFREVRIMKVL 107 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y+VMEY G E+ D V R +A F Q++ + Sbjct: 108 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 163 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H + IVH+D+K NLLL +KI+D G + + F + T GSP + PE+ Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPYAAPEL 220 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VD+WS GV LY + +G PF+G N+ +L E + +G Y IP + Sbjct: 221 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 279 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338 LLK L P+KR ++ QI + W H E + P PD KD R+ +V Sbjct: 280 LLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333 >gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d [Homo sapiens] Length = 788 Score = 152 bits (384), Expect = 6e-37 Identities = 97/294 (32%), Positives = 155/294 (52%), Gaps = 11/294 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y + +G+G++ KVK T AVKI+ K +L + + +E+++++ L Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS--SSLQKLFREVRIMKVL 107 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y+VMEY G E+ D V R +A F Q++ + Sbjct: 108 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 163 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H + IVH+D+K NLLL +KI+D G + + F + T GSP + PE+ Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPYAAPEL 220 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VD+WS GV LY + +G PF+G N+ +L E + +G Y IP + Sbjct: 221 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 279 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338 LLK L P+KR ++ QI + W H E + P PD KD R+ +V Sbjct: 280 LLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333 >gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c [Homo sapiens] Length = 724 Score = 152 bits (384), Expect = 6e-37 Identities = 97/294 (32%), Positives = 155/294 (52%), Gaps = 11/294 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y + +G+G++ KVK T AVKI+ K +L + + +E+++++ L Sbjct: 50 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS--SSLQKLFREVRIMKVL 107 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y+VMEY G E+ D V R +A F Q++ + Sbjct: 108 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 163 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H + IVH+D+K NLLL +KI+D G + + F + T GSP + PE+ Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPYAAPEL 220 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VD+WS GV LY + +G PF+G N+ +L E + +G Y IP + Sbjct: 221 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 279 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338 LLK L P+KR ++ QI + W H E + P PD KD R+ +V Sbjct: 280 LLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333 >gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens] Length = 745 Score = 152 bits (384), Expect = 6e-37 Identities = 97/294 (32%), Positives = 155/294 (52%), Gaps = 11/294 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y + +G+G++ KVK T AVKI+ K +L + + +E+++++ L Sbjct: 17 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS--SSLQKLFREVRIMKVL 74 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y+VMEY G E+ D V R +A F Q++ + Sbjct: 75 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 130 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H + IVH+D+K NLLL +KI+D G + + F + T GSP + PE+ Sbjct: 131 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPYAAPEL 187 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VD+WS GV LY + +G PF+G N+ +L E + +G Y IP + Sbjct: 188 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 246 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338 LLK L P+KR ++ QI + W H E + P PD KD R+ +V Sbjct: 247 LLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300 >gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d [Homo sapiens] Length = 713 Score = 149 bits (377), Expect = 4e-36 Identities = 93/289 (32%), Positives = 149/289 (51%), Gaps = 11/289 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y + +G+G++ KVK T A+KI+ K +L P + +E+++++ L Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKIL 110 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y++MEY G E+ D V R +A F Q++ + Sbjct: 111 NHPNIVKLFEVI--ETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQIVSAV 166 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H + IVH+D+K NLLL +KI+D G + + F T GSP + PE+ Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYAAPEL 223 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VD+WS GV LY + +G PF+G N+ +L E + +G Y IP + Sbjct: 224 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 282 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWR 333 LLK L P KR ++ QI + W H E + P D D+ R Sbjct: 283 LLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKR 331 >gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b [Homo sapiens] Length = 744 Score = 149 bits (377), Expect = 4e-36 Identities = 93/289 (32%), Positives = 149/289 (51%), Gaps = 11/289 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y + +G+G++ KVK T A+KI+ K +L P + +E+++++ L Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKIL 110 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y++MEY G E+ D V R +A F Q++ + Sbjct: 111 NHPNIVKLFEVI--ETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQIVSAV 166 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H + IVH+D+K NLLL +KI+D G + + F T GSP + PE+ Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYAAPEL 223 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VD+WS GV LY + +G PF+G N+ +L E + +G Y IP + Sbjct: 224 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 282 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWR 333 LLK L P KR ++ QI + W H E + P D D+ R Sbjct: 283 LLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKR 331 >gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a [Homo sapiens] Length = 753 Score = 149 bits (377), Expect = 4e-36 Identities = 93/289 (32%), Positives = 149/289 (51%), Gaps = 11/289 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y + +G+G++ KVK T A+KI+ K +L P + +E+++++ L Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKIL 110 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y++MEY G E+ D V R +A F Q++ + Sbjct: 111 NHPNIVKLFEVI--ETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQIVSAV 166 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H + IVH+D+K NLLL +KI+D G + + F T GSP + PE+ Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYAAPEL 223 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VD+WS GV LY + +G PF+G N+ +L E + +G Y IP + Sbjct: 224 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 282 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWR 333 LLK L P KR ++ QI + W H E + P D D+ R Sbjct: 283 LLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKR 331 >gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c [Homo sapiens] Length = 729 Score = 149 bits (377), Expect = 4e-36 Identities = 93/289 (32%), Positives = 149/289 (51%), Gaps = 11/289 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 IG Y + +G+G++ KVK T A+KI+ K +L P + +E+++++ L Sbjct: 53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKIL 110 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y++MEY G E+ D V R +A F Q++ + Sbjct: 111 NHPNIVKLFEVI--ETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQIVSAV 166 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 +Y H + IVH+D+K NLLL +KI+D G + + F T GSP + PE+ Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYAAPEL 223 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VD+WS GV LY + +G PF+G N+ +L E + +G Y IP + Sbjct: 224 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 282 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWR 333 LLK L P KR ++ QI + W H E + P D D+ R Sbjct: 283 LLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKR 331 >gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo sapiens] Length = 688 Score = 147 bits (370), Expect = 2e-35 Identities = 92/294 (31%), Positives = 149/294 (50%), Gaps = 11/294 (3%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 +G Y + +G+G++ KVK T A+KI+ K +L P+ + +E+++++ L Sbjct: 56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PSSLQKLFREVRIMKGL 113 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164 H N+++L +V+ E ++ +Y+VMEY G E+ D V R +A F Q++ + Sbjct: 114 NHPNIVKLFEVI--ETEKTLYLVMEYASAG--EVFDYLVSHGRMKEKEARAKFRQIVSAV 169 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 Y H + IVH+D+K NLLL +KI+D G + + F T GSP + PE+ Sbjct: 170 HYCHQKNIVHRDLKAENLLLDAEANIKIADFGFS---NEFTLGSKLDTFCGSPPYAAPEL 226 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + G +VDIWS GV LY + +G PF+G N+ +L E + +G Y +P Sbjct: 227 FQG-KKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCES 285 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338 +L+ L PAKR ++ QI + W + E P D D R +V Sbjct: 286 ILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMV 339 >gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 2 [Homo sapiens] Length = 541 Score = 146 bits (369), Expect = 3e-35 Identities = 99/288 (34%), Positives = 142/288 (49%), Gaps = 29/288 (10%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90 + +Y + D +G+GSYG VK + A+K+L KKKL R P Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221 Query: 91 G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143 G V +EI +L++L H NV++LV+VL + + +YMV E G +++ Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279 Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203 K QA YF LI G+EYLH Q I+H+DIKP NLL+ G +KI+D GV+ Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338 Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262 +D + G+PAF PE ++ FSG +D+W+ GVTLY G PF + I Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397 Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 308 L I + P D L DL+ ML+ P R + +I+ H W Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 445 >gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 1 [Homo sapiens] Length = 588 Score = 146 bits (369), Expect = 3e-35 Identities = 99/288 (34%), Positives = 142/288 (49%), Gaps = 29/288 (10%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90 + +Y + D +G+GSYG VK + A+K+L KKKL R P Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221 Query: 91 G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143 G V +EI +L++L H NV++LV+VL + + +YMV E G +++ Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279 Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203 K QA YF LI G+EYLH Q I+H+DIKP NLL+ G +KI+D GV+ Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338 Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262 +D + G+PAF PE ++ FSG +D+W+ GVTLY G PF + I Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397 Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 308 L I + P D L DL+ ML+ P R + +I+ H W Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 445 >gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 2 [Homo sapiens] Length = 541 Score = 146 bits (369), Expect = 3e-35 Identities = 99/288 (34%), Positives = 142/288 (49%), Gaps = 29/288 (10%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90 + +Y + D +G+GSYG VK + A+K+L KKKL R P Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221 Query: 91 G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143 G V +EI +L++L H NV++LV+VL + + +YMV E G +++ Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279 Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203 K QA YF LI G+EYLH Q I+H+DIKP NLL+ G +KI+D GV+ Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338 Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262 +D + G+PAF PE ++ FSG +D+W+ GVTLY G PF + I Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397 Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 308 L I + P D L DL+ ML+ P R + +I+ H W Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 445 >gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 5 [Homo sapiens] Length = 533 Score = 146 bits (369), Expect = 3e-35 Identities = 99/288 (34%), Positives = 142/288 (49%), Gaps = 29/288 (10%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90 + +Y + D +G+GSYG VK + A+K+L KKKL R P Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221 Query: 91 G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143 G V +EI +L++L H NV++LV+VL + + +YMV E G +++ Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279 Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203 K QA YF LI G+EYLH Q I+H+DIKP NLL+ G +KI+D GV+ Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338 Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262 +D + G+PAF PE ++ FSG +D+W+ GVTLY G PF + I Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397 Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 308 L I + P D L DL+ ML+ P R + +I+ H W Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 445 >gi|7657214 hormonally upregulated Neu-associated kinase [Homo sapiens] Length = 714 Score = 145 bits (367), Expect = 5e-35 Identities = 92/275 (33%), Positives = 147/275 (53%), Gaps = 11/275 (4%) Query: 44 KLIGKYLMGDL-LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLL 102 K +G YL+G LGEGS+ KV+E L T + A+K++ KK+ ++ N+++E Q+ Sbjct: 56 KRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQ 115 Query: 103 RRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLI 161 + +RH N+ QL+D+L E + Y+VME C G ++ + EK R +A Y QLI Sbjct: 116 QMIRHPNITQLLDIL--ETENSYYLVMELCPGG--NLMHKIYEKKRLEESEARRYIRQLI 171 Query: 162 DGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQP 221 +E+LH G+VH+D+K NLLL +K+ D G++ D T GSPA+ Sbjct: 172 SAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAA 231 Query: 222 PEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPF--EGDNIYKLFEN-IGKGSYAIPGDC 278 PE+ G K+D+WS GV +Y + TG PF E ++ L++ + K +P Sbjct: 232 PELL--ARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289 Query: 279 GPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKH 313 L+ +LE +P KR +I+Q + W + + Sbjct: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENY 324 >gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] Length = 651 Score = 144 bits (364), Expect = 1e-34 Identities = 90/271 (33%), Positives = 143/271 (52%), Gaps = 10/271 (3%) Query: 44 KLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLR 103 +L+ Y + + +G G + KVK T A+KI+ K L + +K EI+ L+ Sbjct: 6 ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG---SDLPRIKTEIEALK 62 Query: 104 RLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV-PEKRFPVCQAHGYFCQLID 162 LRH+++ QL VL E K++MV+EYC G E+ D + + R + F Q++ Sbjct: 63 NLRHQHICQLYHVL--ETANKIFMVLEYCPGG--ELFDYIISQDRLSEEETRVVFRQIVS 118 Query: 163 GLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPP 222 + Y+HSQG H+D+KP NLL LK+ D G+ A D +T GS A+ P Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLC-AKPKGNKDYHLQTCCGSLAYAAP 177 Query: 223 EIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPL 282 E+ G ++ G + D+WS G+ LY + G PF+ DN+ L++ I +G Y +P P Sbjct: 178 ELIQG-KSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSS 236 Query: 283 SDLLKGMLEYEPAKRFSIRQIRQHSWFRKKH 313 LL+ ML+ +P KR S++ + H W + + Sbjct: 237 ILLLQQMLQVDPKKRISMKNLLNHPWIMQDY 267 >gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha isoform a [Homo sapiens] Length = 505 Score = 142 bits (358), Expect = 6e-34 Identities = 100/301 (33%), Positives = 147/301 (48%), Gaps = 32/301 (10%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL--------RRIPNGEA---- 93 + +Y + +G+G+YG V+ + A+K+L KKKL R P G Sbjct: 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 184 Query: 94 ----------NVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143 V +EI +L++L H NV++L++VL + + +Y+V + G +++ Sbjct: 185 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG--PVMEVP 242 Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203 +K F QA Y +I GLEYLH Q IVH+DIKP NLLL G +KI+D GV+ Sbjct: 243 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE- 301 Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262 D ++ G+PAF PE I++ +FSG +D+W+ GVTLY G PF D I Sbjct: 302 -GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360 Query: 263 LFENIGKGSYAIP--GDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPV 320 L I P + L DL+ ML+ P R + I+ H W K E P+ Sbjct: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN---GEEPL 417 Query: 321 P 321 P Sbjct: 418 P 418 >gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha isoform a [Homo sapiens] Length = 505 Score = 142 bits (358), Expect = 6e-34 Identities = 100/301 (33%), Positives = 147/301 (48%), Gaps = 32/301 (10%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL--------RRIPNGEA---- 93 + +Y + +G+G+YG V+ + A+K+L KKKL R P G Sbjct: 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 184 Query: 94 ----------NVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143 V +EI +L++L H NV++L++VL + + +Y+V + G +++ Sbjct: 185 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG--PVMEVP 242 Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203 +K F QA Y +I GLEYLH Q IVH+DIKP NLLL G +KI+D GV+ Sbjct: 243 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE- 301 Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262 D ++ G+PAF PE I++ +FSG +D+W+ GVTLY G PF D I Sbjct: 302 -GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360 Query: 263 LFENIGKGSYAIP--GDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPV 320 L I P + L DL+ ML+ P R + I+ H W K E P+ Sbjct: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN---GEEPL 417 Query: 321 P 321 P Sbjct: 418 P 418 >gi|116256471 SNF1-like kinase [Homo sapiens] Length = 783 Score = 141 bits (355), Expect = 1e-33 Identities = 92/282 (32%), Positives = 146/282 (51%), Gaps = 16/282 (5%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105 +G Y + LG+G++ VK T + A+KI+ K +L + + +E+QL++ L Sbjct: 24 VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDS--SNLEKIYREVQLMKLL 81 Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLIDGL 164 H ++I+L V+ E K +Y+V E+ G EM D + +A F Q++ + Sbjct: 82 NHPHIIKLYQVM--ETKDMLYIVTEFAKNG--EMFDYLTSNGHLSENEARKKFWQILSAV 137 Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224 EY H IVH+D+K NLLL +K++D G + + + T GSP + PE+ Sbjct: 138 EYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNF---YKSGEPLSTWCGSPPYAAPEV 194 Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284 G + + G ++DIWS GV LY + G PF+G N+ L + + +G + IP Sbjct: 195 FEGKE-YEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCES 253 Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSP 326 L++ ML +PA+R +I QIRQH W R AE +P P P Sbjct: 254 LIRRMLVVDPARRITIAQIRQHRWMR-----AEPCLPGPACP 290 >gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 4 [Homo sapiens] Length = 498 Score = 140 bits (353), Expect = 2e-33 Identities = 97/284 (34%), Positives = 140/284 (49%), Gaps = 29/284 (10%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90 + +Y + D +G+GSYG VK + A+K+L KKKL R P Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221 Query: 91 G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143 G V +EI +L++L H NV++LV+VL + + +YMV E G +++ Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279 Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203 K QA YF LI G+EYLH Q I+H+DIKP NLL+ G +KI+D GV+ Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338 Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262 +D + G+PAF PE ++ FSG +D+W+ GVTLY G PF + I Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397 Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIR 304 L I + P D L DL+ ML+ P R + +I+ Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441 >gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 3 [Homo sapiens] Length = 545 Score = 140 bits (353), Expect = 2e-33 Identities = 97/284 (34%), Positives = 140/284 (49%), Gaps = 29/284 (10%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90 + +Y + D +G+GSYG VK + A+K+L KKKL R P Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221 Query: 91 G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143 G V +EI +L++L H NV++LV+VL + + +YMV E G +++ Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279 Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203 K QA YF LI G+EYLH Q I+H+DIKP NLL+ G +KI+D GV+ Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338 Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262 +D + G+PAF PE ++ FSG +D+W+ GVTLY G PF + I Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397 Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIR 304 L I + P D L DL+ ML+ P R + +I+ Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441 >gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2 beta isoform 6 [Homo sapiens] Length = 490 Score = 140 bits (353), Expect = 2e-33 Identities = 97/284 (34%), Positives = 140/284 (49%), Gaps = 29/284 (10%) Query: 46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90 + +Y + D +G+GSYG VK + A+K+L KKKL R P Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221 Query: 91 G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143 G V +EI +L++L H NV++LV+VL + + +YMV E G +++ Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279 Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203 K QA YF LI G+EYLH Q I+H+DIKP NLL+ G +KI+D GV+ Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338 Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262 +D + G+PAF PE ++ FSG +D+W+ GVTLY G PF + I Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397 Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIR 304 L I + P D L DL+ ML+ P R + +I+ Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441 >gi|41872374 polo-like kinase 3 [Homo sapiens] Length = 646 Score = 140 bits (353), Expect = 2e-33 Identities = 91/307 (29%), Positives = 153/307 (49%), Gaps = 25/307 (8%) Query: 30 DSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIP 89 D +I PR R YL G LLG+G + + E D+ET AVK++ + ++ + P Sbjct: 48 DPGRLITDPRSGRT-----YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAK-P 101 Query: 90 NGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFP 149 + + EI+L R L+H+++++ + E+ +Y+ +E C ++ L + + R Sbjct: 102 HQREKILNEIELHRDLQHRHIVRFSH--HFEDADNIYIFLELC---SRKSLAHIWKARHT 156 Query: 150 VCQ--AHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAAD 207 + + Y Q++ GL+YLH +GI+H+D+K GN +T LK+ D G+A L P + Sbjct: 157 LLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEP--PE 214 Query: 208 DTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENI 267 +T G+P + PE+ L G + D+WS G +Y + G PFE ++ + + I Sbjct: 215 QRKKTICGTPNYVAPEVL--LRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCI 272 Query: 268 GKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVP------ 321 + Y +P P LL +L P R SI QI +H +F K + P P+ Sbjct: 273 KQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVP 332 Query: 322 --IPPSP 326 PP+P Sbjct: 333 DLTPPNP 339 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.137 0.411 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,708,357 Number of Sequences: 37866 Number of extensions: 955900 Number of successful extensions: 5287 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 730 Number of HSP's successfully gapped in prelim test: 77 Number of HSP's that attempted gapping in prelim test: 2967 Number of HSP's gapped (non-prelim): 1058 length of query: 433 length of database: 18,247,518 effective HSP length: 105 effective length of query: 328 effective length of database: 14,271,588 effective search space: 4681080864 effective search space used: 4681080864 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.