Guide to the Human Genome
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Search of human proteins with 4507271

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
         (433 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]          885   0.0  
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub...   169   3e-42
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              167   1e-41
gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic sub...   164   1e-40
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               164   1e-40
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...   162   4e-40
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   156   4e-38
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...   152   6e-37
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...   152   6e-37
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...   152   6e-37
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...   152   6e-37
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...   152   6e-37
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   149   4e-36
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   149   4e-36
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   149   4e-36
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   149   4e-36
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   147   2e-35
gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2...   146   3e-35
gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2...   146   3e-35
gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2...   146   3e-35
gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2...   146   3e-35
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa...   145   5e-35
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]    144   1e-34
gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ...   142   6e-34
gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha ...   142   6e-34
gi|116256471 SNF1-like kinase [Homo sapiens]                          141   1e-33
gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2...   140   2e-33
gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2...   140   2e-33
gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2...   140   2e-33
gi|41872374 polo-like kinase 3 [Homo sapiens]                         140   2e-33

>gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
          Length = 433

 Score =  885 bits (2287), Expect = 0.0
 Identities = 433/433 (100%), Positives = 433/433 (100%)

Query: 1   MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSY 60
           MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSY
Sbjct: 1   MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSY 60

Query: 61  GKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE 120
           GKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE
Sbjct: 61  GKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNE 120

Query: 121 EKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG 180
           EKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG
Sbjct: 121 EKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPG 180

Query: 181 NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWS 240
           NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWS
Sbjct: 181 NLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWS 240

Query: 241 AGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI 300
           AGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI
Sbjct: 241 AGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSI 300

Query: 301 RQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDI 360
           RQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDI
Sbjct: 301 RQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDI 360

Query: 361 IYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA 420
           IYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA
Sbjct: 361 IYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSA 420

Query: 421 SSKIRRLSACKQQ 433
           SSKIRRLSACKQQ
Sbjct: 421 SSKIRRLSACKQQ 433


>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 1 [Homo sapiens]
          Length = 559

 Score =  169 bits (429), Expect = 3e-42
 Identities = 99/270 (36%), Positives = 159/270 (58%), Gaps = 10/270 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y++GD LG G++GKVK      T  + AVKIL ++K+R + +    +++EIQ L+  
Sbjct: 24  IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSL-DVVGKIRREIQNLKLF 82

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLIDGL 164
           RH ++I+L  V+       ++MVMEY   G  E+ D + +  R    ++   F Q++ G+
Sbjct: 83  RHPHIIKLYQVI--STPSDIFMVMEYVSGG--ELFDYICKNGRLDEKESRRLFQQILSGV 138

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H   +VH+D+KP N+LL      KI+D G++  +   +  +  RTS GSP +  PE+
Sbjct: 139 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEV 195

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
            +G   ++G +VDIWS+GV LY +  G  PF+ D++  LF+ I  G +  P    P +  
Sbjct: 196 ISGR-LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS 254

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 314
           LLK ML+ +P KR +I+ IR+H WF++  P
Sbjct: 255 LLKHMLQVDPMKRATIKDIREHEWFKQDLP 284


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score =  167 bits (424), Expect = 1e-41
 Identities = 121/410 (29%), Positives = 203/410 (49%), Gaps = 53/410 (12%)

Query: 41  KRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQ 100
           + A+ +G Y +   LG+G  G VK  +   T  + A+KI+ ++KL    +    V++EI 
Sbjct: 11  QHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSE--SVLMKVEREIA 68

Query: 101 LLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQ 159
           +L+ + H +V++L DV   E K+ +Y+V+E+   G  E+ D + +K R    +A  +F Q
Sbjct: 69  ILKLIEHPHVLKLHDVY--ENKKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQ 124

Query: 160 LIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAF 219
           +I  L++ HS  I H+D+KP NLLL     ++I+D G+A        D    TS GSP +
Sbjct: 125 IISALDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMASLQ---VGDSLLETSCGSPHY 181

Query: 220 QPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCG 279
             PE+  G + + G K D+WS GV L+ +  G  PF+ DN+ +L E + +G + +P    
Sbjct: 182 ACPEVIRG-EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP 240

Query: 280 PPLSDLLKGMLEYEPAKRFSIRQIRQHSWF--RKKHPPAEAPVP-------IPP----SP 326
           P    LL+GM+E + A+R ++  I++H W+   K  P  E P+P       +P      P
Sbjct: 241 PDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDP 300

Query: 327 DTKDRWRSMTVV----PYLEDLHGADEDED------LFDIEDDIIYTQDFTVP------- 369
           D  D   S+         L+DL   +E+++      L D ++     +D  +P       
Sbjct: 301 DVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIYFLLLDRKERYPSQEDEDLPPRNEIDP 360

Query: 370 --GQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKA 417
              +V     + +G+RR           E   +   S  +G +P PAR+A
Sbjct: 361 PRKRVDSPMLNRHGKRR----------PERKSMEVLSVTDGGSPVPARRA 400


>gi|94557299 protein kinase, AMP-activated, alpha 1 catalytic
           subunit isoform 2 [Homo sapiens]
          Length = 574

 Score =  164 bits (416), Expect = 1e-40
 Identities = 99/283 (34%), Positives = 159/283 (56%), Gaps = 21/283 (7%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y++GD LG G++GKVK      T  + AVKIL ++K+R + +    +++EIQ L+  
Sbjct: 24  IGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSL-DVVGKIRREIQNLKLF 82

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEY----------CVCGMQEMLDSVPE----KRFPVC 151
           RH ++I+L  V+       ++MVMEY          C  G +  +  V +    K     
Sbjct: 83  RHPHIIKLYQVI--STPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEK 140

Query: 152 QAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCR 211
           ++   F Q++ G++Y H   +VH+D+KP N+LL      KI+D G++  +   +  +  R
Sbjct: 141 ESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLR 197

Query: 212 TSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGS 271
           TS GSP +  PE+ +G   ++G +VDIWS+GV LY +  G  PF+ D++  LF+ I  G 
Sbjct: 198 TSCGSPNYAAPEVISGR-LYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI 256

Query: 272 YAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 314
           +  P    P +  LLK ML+ +P KR +I+ IR+H WF++  P
Sbjct: 257 FYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLP 299


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  164 bits (416), Expect = 1e-40
 Identities = 98/285 (34%), Positives = 159/285 (55%), Gaps = 12/285 (4%)

Query: 41  KRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQ 100
           + A+ +G Y +   LG+G  G VK  +   T  + A+KI+ ++KL    +    V++EI 
Sbjct: 26  QHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSE--SVLMKVEREIA 83

Query: 101 LLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQ 159
           +L+ + H +V++L DV   E K+ +Y+V+E+   G  E+ D + +K R    +A  +F Q
Sbjct: 84  ILKLIEHPHVLKLHDVY--ENKKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQ 139

Query: 160 LIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAF 219
           ++  L++ HS  I H+D+KP NLLL     ++I+D G+A        D    TS GSP +
Sbjct: 140 IVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQ---VGDSLLETSCGSPHY 196

Query: 220 QPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCG 279
             PE+  G + + G + D+WS GV L+ +  G  PF+ DN+ +L E + +G + +P    
Sbjct: 197 ACPEVIKG-EKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP 255

Query: 280 PPLSDLLKGMLEYEPAKRFSIRQIRQHSWF-RKKHPPAEAPVPIP 323
           P    LL+GM+E EP KR S+ QI++H W+   KH P     P P
Sbjct: 256 PDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAP 300


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score =  162 bits (411), Expect = 4e-40
 Identities = 98/270 (36%), Positives = 156/270 (57%), Gaps = 10/270 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y++GD LG G++GKVK      T  + AVKIL ++K+R + +    +K+EIQ L+  
Sbjct: 13  IGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSL-DVVGKIKREIQNLKLF 71

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLIDGL 164
           RH ++I+L  V+        +MVMEY   G  E+ D + +  R    +A   F Q++  +
Sbjct: 72  RHPHIIKLYQVI--STPTDFFMVMEYVSGG--ELFDYICKHGRVEEMEARRLFQQILSAV 127

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H   +VH+D+KP N+LL      KI+D G++  +   +  +  RTS GSP +  PE+
Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEV 184

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
            +G   ++G +VDIWS GV LY +  G  PF+ +++  LF+ I  G + IP      ++ 
Sbjct: 185 ISGR-LYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVAT 243

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHP 314
           LL  ML+ +P KR +I+ IR+H WF++  P
Sbjct: 244 LLMHMLQVDPLKRATIKDIREHEWFKQDLP 273


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  156 bits (394), Expect = 4e-38
 Identities = 115/386 (29%), Positives = 187/386 (48%), Gaps = 22/386 (5%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y +   +G+G++ KVK      T    AVKI+ K +L   P     + +E+++++ L
Sbjct: 57  IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN--PTSLQKLFREVRIMKIL 114

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y+VMEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 115 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 170

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H + IVH+D+K  NLLL     +KI+D G +   + F   +   T  GSP +  PE+
Sbjct: 171 QYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFS---NEFTVGNKLDTFCGSPPYAAPEL 227

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VD+WS GV LY + +G  PF+G N+ +L E + +G Y IP        +
Sbjct: 228 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 286

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWR--SMTVVPYLE 342
           LLK +L   P KR S+ QI +  W    H   E      P PD  D  R   M  + +  
Sbjct: 287 LLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFAR 346

Query: 343 DLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLST 402
           D    + ++ L + + D +      +  + PE E   +     L    C     ++ L+ 
Sbjct: 347 D----EINDALINQKYDEVMATYILLGRKPPEFEGGESLSSGNL----CQRSRPSSDLN- 397

Query: 403 KSRAEGRAPNPARKACSASSKIRRLS 428
            S  +  A    +++ SA+ K RR S
Sbjct: 398 NSTLQSPAHLKVQRSISANQKQRRFS 423


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score =  152 bits (384), Expect = 6e-37
 Identities = 97/294 (32%), Positives = 155/294 (52%), Gaps = 11/294 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y +   +G+G++ KVK      T    AVKI+ K +L    +    + +E+++++ L
Sbjct: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS--SSLQKLFREVRIMKVL 107

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y+VMEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 108 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 163

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H + IVH+D+K  NLLL     +KI+D G +   + F   +   T  GSP +  PE+
Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPYAAPEL 220

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VD+WS GV LY + +G  PF+G N+ +L E + +G Y IP        +
Sbjct: 221 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 279

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338
           LLK  L   P+KR ++ QI +  W    H   E    + P PD KD  R+  +V
Sbjct: 280 LLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score =  152 bits (384), Expect = 6e-37
 Identities = 97/294 (32%), Positives = 155/294 (52%), Gaps = 11/294 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y +   +G+G++ KVK      T    AVKI+ K +L    +    + +E+++++ L
Sbjct: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS--SSLQKLFREVRIMKVL 107

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y+VMEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 108 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 163

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H + IVH+D+K  NLLL     +KI+D G +   + F   +   T  GSP +  PE+
Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPYAAPEL 220

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VD+WS GV LY + +G  PF+G N+ +L E + +G Y IP        +
Sbjct: 221 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 279

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338
           LLK  L   P+KR ++ QI +  W    H   E    + P PD KD  R+  +V
Sbjct: 280 LLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score =  152 bits (384), Expect = 6e-37
 Identities = 97/294 (32%), Positives = 155/294 (52%), Gaps = 11/294 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y +   +G+G++ KVK      T    AVKI+ K +L    +    + +E+++++ L
Sbjct: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS--SSLQKLFREVRIMKVL 107

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y+VMEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 108 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 163

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H + IVH+D+K  NLLL     +KI+D G +   + F   +   T  GSP +  PE+
Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPYAAPEL 220

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VD+WS GV LY + +G  PF+G N+ +L E + +G Y IP        +
Sbjct: 221 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 279

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338
           LLK  L   P+KR ++ QI +  W    H   E    + P PD KD  R+  +V
Sbjct: 280 LLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score =  152 bits (384), Expect = 6e-37
 Identities = 97/294 (32%), Positives = 155/294 (52%), Gaps = 11/294 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y +   +G+G++ KVK      T    AVKI+ K +L    +    + +E+++++ L
Sbjct: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS--SSLQKLFREVRIMKVL 107

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y+VMEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 108 NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 163

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H + IVH+D+K  NLLL     +KI+D G +   + F   +   T  GSP +  PE+
Sbjct: 164 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPYAAPEL 220

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VD+WS GV LY + +G  PF+G N+ +L E + +G Y IP        +
Sbjct: 221 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 279

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338
           LLK  L   P+KR ++ QI +  W    H   E    + P PD KD  R+  +V
Sbjct: 280 LLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 333


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score =  152 bits (384), Expect = 6e-37
 Identities = 97/294 (32%), Positives = 155/294 (52%), Gaps = 11/294 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y +   +G+G++ KVK      T    AVKI+ K +L    +    + +E+++++ L
Sbjct: 17  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS--SSLQKLFREVRIMKVL 74

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y+VMEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 75  NHPNIVKLFEVI--ETEKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAV 130

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H + IVH+D+K  NLLL     +KI+D G +   + F   +   T  GSP +  PE+
Sbjct: 131 QYCHQKFIVHRDLKAENLLLDADMNIKIADFGFS---NEFTFGNKLDTFCGSPPYAAPEL 187

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VD+WS GV LY + +G  PF+G N+ +L E + +G Y IP        +
Sbjct: 188 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 246

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338
           LLK  L   P+KR ++ QI +  W    H   E    + P PD KD  R+  +V
Sbjct: 247 LLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMV 300


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  149 bits (377), Expect = 4e-36
 Identities = 93/289 (32%), Positives = 149/289 (51%), Gaps = 11/289 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y +   +G+G++ KVK      T    A+KI+ K +L   P     + +E+++++ L
Sbjct: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKIL 110

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y++MEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 111 NHPNIVKLFEVI--ETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQIVSAV 166

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H + IVH+D+K  NLLL     +KI+D G +   + F       T  GSP +  PE+
Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYAAPEL 223

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VD+WS GV LY + +G  PF+G N+ +L E + +G Y IP        +
Sbjct: 224 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 282

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWR 333
           LLK  L   P KR ++ QI +  W    H   E    + P  D  D+ R
Sbjct: 283 LLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKR 331


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  149 bits (377), Expect = 4e-36
 Identities = 93/289 (32%), Positives = 149/289 (51%), Gaps = 11/289 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y +   +G+G++ KVK      T    A+KI+ K +L   P     + +E+++++ L
Sbjct: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKIL 110

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y++MEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 111 NHPNIVKLFEVI--ETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQIVSAV 166

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H + IVH+D+K  NLLL     +KI+D G +   + F       T  GSP +  PE+
Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYAAPEL 223

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VD+WS GV LY + +G  PF+G N+ +L E + +G Y IP        +
Sbjct: 224 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 282

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWR 333
           LLK  L   P KR ++ QI +  W    H   E    + P  D  D+ R
Sbjct: 283 LLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKR 331


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  149 bits (377), Expect = 4e-36
 Identities = 93/289 (32%), Positives = 149/289 (51%), Gaps = 11/289 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y +   +G+G++ KVK      T    A+KI+ K +L   P     + +E+++++ L
Sbjct: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKIL 110

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y++MEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 111 NHPNIVKLFEVI--ETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQIVSAV 166

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H + IVH+D+K  NLLL     +KI+D G +   + F       T  GSP +  PE+
Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYAAPEL 223

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VD+WS GV LY + +G  PF+G N+ +L E + +G Y IP        +
Sbjct: 224 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 282

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWR 333
           LLK  L   P KR ++ QI +  W    H   E    + P  D  D+ R
Sbjct: 283 LLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKR 331


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  149 bits (377), Expect = 4e-36
 Identities = 93/289 (32%), Positives = 149/289 (51%), Gaps = 11/289 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           IG Y +   +G+G++ KVK      T    A+KI+ K +L   P     + +E+++++ L
Sbjct: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKIL 110

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y++MEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 111 NHPNIVKLFEVI--ETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQIVSAV 166

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           +Y H + IVH+D+K  NLLL     +KI+D G +   + F       T  GSP +  PE+
Sbjct: 167 QYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS---NEFTVGGKLDTFCGSPPYAAPEL 223

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VD+WS GV LY + +G  PF+G N+ +L E + +G Y IP        +
Sbjct: 224 FQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEN 282

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWR 333
           LLK  L   P KR ++ QI +  W    H   E    + P  D  D+ R
Sbjct: 283 LLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKR 331


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  147 bits (370), Expect = 2e-35
 Identities = 92/294 (31%), Positives = 149/294 (50%), Gaps = 11/294 (3%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           +G Y +   +G+G++ KVK      T    A+KI+ K +L   P+    + +E+++++ L
Sbjct: 56  VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PSSLQKLFREVRIMKGL 113

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKRFPVCQAHGYFCQLIDGL 164
            H N+++L +V+  E ++ +Y+VMEY   G  E+ D  V   R    +A   F Q++  +
Sbjct: 114 NHPNIVKLFEVI--ETEKTLYLVMEYASAG--EVFDYLVSHGRMKEKEARAKFRQIVSAV 169

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
            Y H + IVH+D+K  NLLL     +KI+D G +   + F       T  GSP +  PE+
Sbjct: 170 HYCHQKNIVHRDLKAENLLLDAEANIKIADFGFS---NEFTLGSKLDTFCGSPPYAAPEL 226

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G   + G +VDIWS GV LY + +G  PF+G N+ +L E + +G Y +P         
Sbjct: 227 FQG-KKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCES 285

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVV 338
           +L+  L   PAKR ++ QI +  W    +   E      P  D  D  R   +V
Sbjct: 286 ILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMV 339


>gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 2 [Homo sapiens]
          Length = 541

 Score =  146 bits (369), Expect = 3e-35
 Identities = 99/288 (34%), Positives = 142/288 (49%), Gaps = 29/288 (10%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90
           + +Y + D +G+GSYG VK   +       A+K+L KKKL               R  P 
Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221

Query: 91  G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
           G          V +EI +L++L H NV++LV+VL +  +  +YMV E    G   +++  
Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279

Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
             K     QA  YF  LI G+EYLH Q I+H+DIKP NLL+   G +KI+D GV+     
Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338

Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
             +D     + G+PAF  PE ++     FSG  +D+W+ GVTLY    G  PF  + I  
Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397

Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 308
           L   I   +   P   D    L DL+  ML+  P  R  + +I+ H W
Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 445


>gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 1 [Homo sapiens]
          Length = 588

 Score =  146 bits (369), Expect = 3e-35
 Identities = 99/288 (34%), Positives = 142/288 (49%), Gaps = 29/288 (10%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90
           + +Y + D +G+GSYG VK   +       A+K+L KKKL               R  P 
Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221

Query: 91  G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
           G          V +EI +L++L H NV++LV+VL +  +  +YMV E    G   +++  
Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279

Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
             K     QA  YF  LI G+EYLH Q I+H+DIKP NLL+   G +KI+D GV+     
Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338

Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
             +D     + G+PAF  PE ++     FSG  +D+W+ GVTLY    G  PF  + I  
Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397

Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 308
           L   I   +   P   D    L DL+  ML+  P  R  + +I+ H W
Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 445


>gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 2 [Homo sapiens]
          Length = 541

 Score =  146 bits (369), Expect = 3e-35
 Identities = 99/288 (34%), Positives = 142/288 (49%), Gaps = 29/288 (10%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90
           + +Y + D +G+GSYG VK   +       A+K+L KKKL               R  P 
Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221

Query: 91  G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
           G          V +EI +L++L H NV++LV+VL +  +  +YMV E    G   +++  
Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279

Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
             K     QA  YF  LI G+EYLH Q I+H+DIKP NLL+   G +KI+D GV+     
Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338

Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
             +D     + G+PAF  PE ++     FSG  +D+W+ GVTLY    G  PF  + I  
Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397

Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 308
           L   I   +   P   D    L DL+  ML+  P  R  + +I+ H W
Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 445


>gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 5 [Homo sapiens]
          Length = 533

 Score =  146 bits (369), Expect = 3e-35
 Identities = 99/288 (34%), Positives = 142/288 (49%), Gaps = 29/288 (10%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90
           + +Y + D +G+GSYG VK   +       A+K+L KKKL               R  P 
Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221

Query: 91  G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
           G          V +EI +L++L H NV++LV+VL +  +  +YMV E    G   +++  
Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279

Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
             K     QA  YF  LI G+EYLH Q I+H+DIKP NLL+   G +KI+D GV+     
Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338

Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
             +D     + G+PAF  PE ++     FSG  +D+W+ GVTLY    G  PF  + I  
Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397

Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSW 308
           L   I   +   P   D    L DL+  ML+  P  R  + +I+ H W
Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPW 445


>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
           sapiens]
          Length = 714

 Score =  145 bits (367), Expect = 5e-35
 Identities = 92/275 (33%), Positives = 147/275 (53%), Gaps = 11/275 (4%)

Query: 44  KLIGKYLMGDL-LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLL 102
           K +G YL+G   LGEGS+ KV+E L   T  + A+K++ KK+ ++      N+++E Q+ 
Sbjct: 56  KRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQ 115

Query: 103 RRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLI 161
           + +RH N+ QL+D+L  E +   Y+VME C  G   ++  + EK R    +A  Y  QLI
Sbjct: 116 QMIRHPNITQLLDIL--ETENSYYLVMELCPGG--NLMHKIYEKKRLEESEARRYIRQLI 171

Query: 162 DGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQP 221
             +E+LH  G+VH+D+K  NLLL     +K+ D G++         D   T  GSPA+  
Sbjct: 172 SAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAA 231

Query: 222 PEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPF--EGDNIYKLFEN-IGKGSYAIPGDC 278
           PE+        G K+D+WS GV +Y + TG  PF  E  ++  L++  + K    +P   
Sbjct: 232 PELL--ARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQL 289

Query: 279 GPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKH 313
                  L+ +LE +P KR +I+Q   + W  + +
Sbjct: 290 STGAISFLRSLLEPDPVKRPNIQQALANRWLNENY 324


>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score =  144 bits (364), Expect = 1e-34
 Identities = 90/271 (33%), Positives = 143/271 (52%), Gaps = 10/271 (3%)

Query: 44  KLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLR 103
           +L+  Y + + +G G + KVK      T    A+KI+ K  L    +    +K EI+ L+
Sbjct: 6   ELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG---SDLPRIKTEIEALK 62

Query: 104 RLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV-PEKRFPVCQAHGYFCQLID 162
            LRH+++ QL  VL  E   K++MV+EYC  G  E+ D +  + R    +    F Q++ 
Sbjct: 63  NLRHQHICQLYHVL--ETANKIFMVLEYCPGG--ELFDYIISQDRLSEEETRVVFRQIVS 118

Query: 163 GLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPP 222
            + Y+HSQG  H+D+KP NLL      LK+ D G+  A      D   +T  GS A+  P
Sbjct: 119 AVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLC-AKPKGNKDYHLQTCCGSLAYAAP 177

Query: 223 EIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPL 282
           E+  G  ++ G + D+WS G+ LY +  G  PF+ DN+  L++ I +G Y +P    P  
Sbjct: 178 ELIQG-KSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSS 236

Query: 283 SDLLKGMLEYEPAKRFSIRQIRQHSWFRKKH 313
             LL+ ML+ +P KR S++ +  H W  + +
Sbjct: 237 ILLLQQMLQVDPKKRISMKNLLNHPWIMQDY 267


>gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform a [Homo sapiens]
          Length = 505

 Score =  142 bits (358), Expect = 6e-34
 Identities = 100/301 (33%), Positives = 147/301 (48%), Gaps = 32/301 (10%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL--------RRIPNGEA---- 93
           + +Y +   +G+G+YG V+   +       A+K+L KKKL        R  P G      
Sbjct: 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 184

Query: 94  ----------NVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
                      V +EI +L++L H NV++L++VL +  +  +Y+V +    G   +++  
Sbjct: 185 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG--PVMEVP 242

Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
            +K F   QA  Y   +I GLEYLH Q IVH+DIKP NLLL   G +KI+D GV+     
Sbjct: 243 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE- 301

Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
              D    ++ G+PAF  PE I++   +FSG  +D+W+ GVTLY    G  PF  D I  
Sbjct: 302 -GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360

Query: 263 LFENIGKGSYAIP--GDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPV 320
           L   I       P   +    L DL+  ML+  P  R  +  I+ H W  K     E P+
Sbjct: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN---GEEPL 417

Query: 321 P 321
           P
Sbjct: 418 P 418


>gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha
           isoform a [Homo sapiens]
          Length = 505

 Score =  142 bits (358), Expect = 6e-34
 Identities = 100/301 (33%), Positives = 147/301 (48%), Gaps = 32/301 (10%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL--------RRIPNGEA---- 93
           + +Y +   +G+G+YG V+   +       A+K+L KKKL        R  P G      
Sbjct: 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQG 184

Query: 94  ----------NVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
                      V +EI +L++L H NV++L++VL +  +  +Y+V +    G   +++  
Sbjct: 185 GPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKG--PVMEVP 242

Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
            +K F   QA  Y   +I GLEYLH Q IVH+DIKP NLLL   G +KI+D GV+     
Sbjct: 243 CDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE- 301

Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
              D    ++ G+PAF  PE I++   +FSG  +D+W+ GVTLY    G  PF  D I  
Sbjct: 302 -GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 360

Query: 263 LFENIGKGSYAIP--GDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPV 320
           L   I       P   +    L DL+  ML+  P  R  +  I+ H W  K     E P+
Sbjct: 361 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKN---GEEPL 417

Query: 321 P 321
           P
Sbjct: 418 P 418


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  141 bits (355), Expect = 1e-33
 Identities = 92/282 (32%), Positives = 146/282 (51%), Gaps = 16/282 (5%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL 105
           +G Y +   LG+G++  VK      T  + A+KI+ K +L    +    + +E+QL++ L
Sbjct: 24  VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDS--SNLEKIYREVQLMKLL 81

Query: 106 RHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFCQLIDGL 164
            H ++I+L  V+  E K  +Y+V E+   G  EM D +         +A   F Q++  +
Sbjct: 82  NHPHIIKLYQVM--ETKDMLYIVTEFAKNG--EMFDYLTSNGHLSENEARKKFWQILSAV 137

Query: 165 EYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEI 224
           EY H   IVH+D+K  NLLL     +K++D G       + + +   T  GSP +  PE+
Sbjct: 138 EYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNF---YKSGEPLSTWCGSPPYAAPEV 194

Query: 225 ANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSD 284
             G + + G ++DIWS GV LY +  G  PF+G N+  L + + +G + IP         
Sbjct: 195 FEGKE-YEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCES 253

Query: 285 LLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSP 326
           L++ ML  +PA+R +I QIRQH W R     AE  +P P  P
Sbjct: 254 LIRRMLVVDPARRITIAQIRQHRWMR-----AEPCLPGPACP 290


>gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 4 [Homo sapiens]
          Length = 498

 Score =  140 bits (353), Expect = 2e-33
 Identities = 97/284 (34%), Positives = 140/284 (49%), Gaps = 29/284 (10%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90
           + +Y + D +G+GSYG VK   +       A+K+L KKKL               R  P 
Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221

Query: 91  G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
           G          V +EI +L++L H NV++LV+VL +  +  +YMV E    G   +++  
Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279

Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
             K     QA  YF  LI G+EYLH Q I+H+DIKP NLL+   G +KI+D GV+     
Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338

Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
             +D     + G+PAF  PE ++     FSG  +D+W+ GVTLY    G  PF  + I  
Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397

Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIR 304
           L   I   +   P   D    L DL+  ML+  P  R  + +I+
Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441


>gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 3 [Homo sapiens]
          Length = 545

 Score =  140 bits (353), Expect = 2e-33
 Identities = 97/284 (34%), Positives = 140/284 (49%), Gaps = 29/284 (10%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90
           + +Y + D +G+GSYG VK   +       A+K+L KKKL               R  P 
Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221

Query: 91  G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
           G          V +EI +L++L H NV++LV+VL +  +  +YMV E    G   +++  
Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279

Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
             K     QA  YF  LI G+EYLH Q I+H+DIKP NLL+   G +KI+D GV+     
Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338

Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
             +D     + G+PAF  PE ++     FSG  +D+W+ GVTLY    G  PF  + I  
Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397

Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIR 304
           L   I   +   P   D    L DL+  ML+  P  R  + +I+
Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441


>gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2
           beta isoform 6 [Homo sapiens]
          Length = 490

 Score =  140 bits (353), Expect = 2e-33
 Identities = 97/284 (34%), Positives = 140/284 (49%), Gaps = 29/284 (10%)

Query: 46  IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL---------------RRIPN 90
           + +Y + D +G+GSYG VK   +       A+K+L KKKL               R  P 
Sbjct: 162 LNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPG 221

Query: 91  G-------EANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSV 143
           G          V +EI +L++L H NV++LV+VL +  +  +YMV E    G   +++  
Sbjct: 222 GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQG--PVMEVP 279

Query: 144 PEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHP 203
             K     QA  YF  LI G+EYLH Q I+H+DIKP NLL+   G +KI+D GV+     
Sbjct: 280 TLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK- 338

Query: 204 FAADDTCRTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYK 262
             +D     + G+PAF  PE ++     FSG  +D+W+ GVTLY    G  PF  + I  
Sbjct: 339 -GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 397

Query: 263 LFENIGKGSYAIPG--DCGPPLSDLLKGMLEYEPAKRFSIRQIR 304
           L   I   +   P   D    L DL+  ML+  P  R  + +I+
Sbjct: 398 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK 441


>gi|41872374 polo-like kinase 3 [Homo sapiens]
          Length = 646

 Score =  140 bits (353), Expect = 2e-33
 Identities = 91/307 (29%), Positives = 153/307 (49%), Gaps = 25/307 (8%)

Query: 30  DSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIP 89
           D   +I  PR  R      YL G LLG+G + +  E  D+ET    AVK++ + ++ + P
Sbjct: 48  DPGRLITDPRSGRT-----YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAK-P 101

Query: 90  NGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFP 149
           +    +  EI+L R L+H+++++     + E+   +Y+ +E C    ++ L  + + R  
Sbjct: 102 HQREKILNEIELHRDLQHRHIVRFSH--HFEDADNIYIFLELC---SRKSLAHIWKARHT 156

Query: 150 VCQ--AHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAAD 207
           + +     Y  Q++ GL+YLH +GI+H+D+K GN  +T    LK+ D G+A  L P   +
Sbjct: 157 LLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEP--PE 214

Query: 208 DTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENI 267
              +T  G+P +  PE+   L    G + D+WS G  +Y +  G  PFE  ++ + +  I
Sbjct: 215 QRKKTICGTPNYVAPEVL--LRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCI 272

Query: 268 GKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVP------ 321
            +  Y +P     P   LL  +L   P  R SI QI +H +F K + P   P+       
Sbjct: 273 KQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVP 332

Query: 322 --IPPSP 326
              PP+P
Sbjct: 333 DLTPPNP 339


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,708,357
Number of Sequences: 37866
Number of extensions: 955900
Number of successful extensions: 5287
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 730
Number of HSP's successfully gapped in prelim test: 77
Number of HSP's that attempted gapping in prelim test: 2967
Number of HSP's gapped (non-prelim): 1058
length of query: 433
length of database: 18,247,518
effective HSP length: 105
effective length of query: 328
effective length of database: 14,271,588
effective search space: 4681080864
effective search space used: 4681080864
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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