Guide to the Human Genome
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Search of human proteins with 4507091

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507091 survival of motor neuron 1, telomeric isoform d
[Homo sapiens]
         (294 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10937869 survival of motor neuron 2, centromeric isoform d [H...   629   0.0  
gi|4507091 survival of motor neuron 1, telomeric isoform d [Homo...   629   0.0  
gi|13259527 survival of motor neuron 2, centromeric isoform a [H...   595   e-170
gi|13259529 survival of motor neuron 2, centromeric isoform b [H...   534   e-152
gi|13259512 survival of motor neuron 1, telomeric isoform b [Hom...   534   e-152
gi|13259531 survival of motor neuron 2, centromeric isoform c [H...   499   e-142
gi|157168329 formin 1 [Homo sapiens]                                   64   1e-10
gi|33356148 formin-like 1 [Homo sapiens]                               62   5e-10
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                     61   1e-09
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                     61   1e-09
gi|210032580 SET domain containing 1B [Homo sapiens]                   60   2e-09
gi|126723060 zinc finger CCCH-type containing 4 [Homo sapiens]         60   2e-09
gi|5032113 survival motor neuron domain containing 1 [Homo sapiens]    60   2e-09
gi|160707881 formin 2 [Homo sapiens]                                   60   3e-09
gi|56549694 enabled homolog isoform a [Homo sapiens]                   59   4e-09
gi|39930375 enabled homolog isoform b [Homo sapiens]                   59   4e-09
gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]              58   9e-09
gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]             58   9e-09
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]                57   1e-08
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]                57   1e-08
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap...    57   2e-08
gi|55741677 SET domain containing 1A [Homo sapiens]                    57   2e-08
gi|169163027 PREDICTED: similar to Putative acrosin-like proteas...    57   3e-08
gi|150417989 cyclin K isoform 1 [Homo sapiens]                         55   6e-08
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ...    55   7e-08
gi|11386183 WAS protein family, member 2 [Homo sapiens]                55   1e-07
gi|126090663 zinc finger homeodomain 4 [Homo sapiens]                  55   1e-07
gi|153792074 proline rich 12 [Homo sapiens]                            54   1e-07
gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]                     54   2e-07
gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]                     54   2e-07

>gi|10937869 survival of motor neuron 2, centromeric isoform d [Homo
           sapiens]
          Length = 294

 Score =  629 bits (1623), Expect = 0.0
 Identities = 294/294 (100%), Positives = 294/294 (100%)

Query: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60
           MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC
Sbjct: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60

Query: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120
           ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR
Sbjct: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120

Query: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180
           ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS
Sbjct: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180

Query: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP 240
           DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP
Sbjct: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP 240

Query: 241 PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN 294
           PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN
Sbjct: 241 PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN 294


>gi|4507091 survival of motor neuron 1, telomeric isoform d [Homo
           sapiens]
          Length = 294

 Score =  629 bits (1623), Expect = 0.0
 Identities = 294/294 (100%), Positives = 294/294 (100%)

Query: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60
           MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC
Sbjct: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60

Query: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120
           ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR
Sbjct: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120

Query: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180
           ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS
Sbjct: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180

Query: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP 240
           DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP
Sbjct: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP 240

Query: 241 PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN 294
           PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN
Sbjct: 241 PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN 294


>gi|13259527 survival of motor neuron 2, centromeric isoform a [Homo
           sapiens]
          Length = 282

 Score =  595 bits (1534), Expect = e-170
 Identities = 278/278 (100%), Positives = 278/278 (100%)

Query: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60
           MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC
Sbjct: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60

Query: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120
           ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR
Sbjct: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120

Query: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180
           ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS
Sbjct: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180

Query: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP 240
           DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP
Sbjct: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP 240

Query: 241 PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYM 278
           PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYM
Sbjct: 241 PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYM 278


>gi|13259529 survival of motor neuron 2, centromeric isoform b [Homo
           sapiens]
          Length = 262

 Score =  534 bits (1375), Expect = e-152
 Identities = 262/294 (89%), Positives = 262/294 (89%), Gaps = 32/294 (10%)

Query: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60
           MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC
Sbjct: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60

Query: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120
           ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR
Sbjct: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120

Query: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180
           ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS
Sbjct: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180

Query: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP 240
           DNIKPKSAPWNSFLPPPPPMPGPRLGPGK                               
Sbjct: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGK------------------------------- 209

Query: 241 PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN 294
            IIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN
Sbjct: 210 -IIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN 262


>gi|13259512 survival of motor neuron 1, telomeric isoform b [Homo
           sapiens]
          Length = 262

 Score =  534 bits (1375), Expect = e-152
 Identities = 262/294 (89%), Positives = 262/294 (89%), Gaps = 32/294 (10%)

Query: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60
           MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC
Sbjct: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60

Query: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120
           ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR
Sbjct: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120

Query: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180
           ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS
Sbjct: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180

Query: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP 240
           DNIKPKSAPWNSFLPPPPPMPGPRLGPGK                               
Sbjct: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGK------------------------------- 209

Query: 241 PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN 294
            IIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN
Sbjct: 210 -IIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN 262


>gi|13259531 survival of motor neuron 2, centromeric isoform c [Homo
           sapiens]
          Length = 250

 Score =  499 bits (1286), Expect = e-142
 Identities = 246/278 (88%), Positives = 246/278 (88%), Gaps = 32/278 (11%)

Query: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60
           MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC
Sbjct: 1   MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDIC 60

Query: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120
           ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR
Sbjct: 61  ETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKR 120

Query: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180
           ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS
Sbjct: 121 ETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKS 180

Query: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGP 240
           DNIKPKSAPWNSFLPPPPPMPGPRLGPGK                               
Sbjct: 181 DNIKPKSAPWNSFLPPPPPMPGPRLGPGK------------------------------- 209

Query: 241 PIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYM 278
            IIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYM
Sbjct: 210 -IIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYM 246


>gi|157168329 formin 1 [Homo sapiens]
          Length = 1196

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 30/58 (51%), Positives = 32/58 (55%), Gaps = 7/58 (12%)

Query: 194 LPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICP 251
           LPPPPP P P   P   G       PPPPPPPP L +   PP P GPP  PPPP + P
Sbjct: 680 LPPPPPPPPPLPPPSSAG-------PPPPPPPPPLPNSPAPPNPGGPPPAPPPPGLAP 730



 Score = 52.0 bits (123), Expect = 6e-07
 Identities = 29/64 (45%), Positives = 33/64 (51%), Gaps = 12/64 (18%)

Query: 195 PPPPPMPGP--------RLGPGKPGLKFN-GPPPPPPPPPPHLLSCWLPPFPSGPPIIPP 245
           PPP  +P P         L P  P    + GPP PPPPPPP  L    PP  +GPP  PP
Sbjct: 647 PPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLP---PPSSAGPPPPPP 703

Query: 246 PPPI 249
           PPP+
Sbjct: 704 PPPL 707



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 31/75 (41%), Positives = 32/75 (42%), Gaps = 12/75 (16%)

Query: 185 PKSAPWNSFLPPPPPMPGP---RLGPGKPGLKFNGPPPPPP-----PPPPHLLSCWLPPF 236
           P   P +S  PPPPP P P      P  PG    GPPP PP     PPPP  L   L   
Sbjct: 688 PPLPPPSSAGPPPPPPPPPLPNSPAPPNPG----GPPPAPPPPGLAPPPPPGLFFGLGSS 743

Query: 237 PSGPPIIPPPPPICP 251
            S  P  P   P CP
Sbjct: 744 SSQCPRKPAIEPSCP 758



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 21/44 (47%), Positives = 24/44 (54%), Gaps = 9/44 (20%)

Query: 217 PPPPPP-PPPPHLLSCW--------LPPFPSGPPIIPPPPPICP 251
           PPPP   PPPP L S          +PP  +GPP+ PPPPP  P
Sbjct: 646 PPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPP 689


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 37/84 (44%), Positives = 41/84 (48%), Gaps = 8/84 (9%)

Query: 176 PGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPP 235
           PG  S    P SAP     P  PP+PG    P  P L  + PPPPPPPPPP        P
Sbjct: 549 PGLPSPQEAPPSAP-----PQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTD---GP 600

Query: 236 FPSGPPIIPPPPPICPDSLDDADA 259
            P  PP  PPPP   PD+L   D+
Sbjct: 601 VPPPPPPPPPPPGGPPDALGRRDS 624



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 37/124 (29%), Positives = 46/124 (37%), Gaps = 38/124 (30%)

Query: 165 VSTDESENSRSPGNKSDNIKPKSAPW-----NSFLPPPPPMPGPRLGPGKPGLKFNGPPP 219
           V+T    ++ +PG  + +  P  AP       +  PPPPP+PG              P  
Sbjct: 508 VATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPG-----------LPSPQE 556

Query: 220 PPP--------------PPPPHLLSCWLPPFPSGP--------PIIPPPPPICPDSLDDA 257
            PP              PPP   L   LPP P  P        P+ PPPPP  P      
Sbjct: 557 APPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGPP 616

Query: 258 DALG 261
           DALG
Sbjct: 617 DALG 620


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 35/78 (44%), Positives = 39/78 (50%), Gaps = 15/78 (19%)

Query: 185 PKSAPWNSFLPPPPPMPG----PRLGPGKPGLKFNGPPPPP--------PPPPPHLLSCW 232
           P S P  + +PPPPP+PG    P   P  PG     PPPPP        PPPPP      
Sbjct: 657 PSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPG 716

Query: 233 L---PPFPSGPPIIPPPP 247
           +   PPFP GP I PPPP
Sbjct: 717 IPPPPPFPGGPGIPPPPP 734



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 39/129 (30%), Positives = 54/129 (41%), Gaps = 27/129 (20%)

Query: 135 EQNLSDLLSPICEVANNIEQNAQENENESQ--VSTDESENSRSP--------GNKSDNIK 184
           E  +S L   + ++   +E   +E  + S   ++   S  SR+P        G+    I 
Sbjct: 529 EAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIP 588

Query: 185 PKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIP 244
           P  AP +S  PPPPP                 PPPPPPPP P  +    PP   G   I 
Sbjct: 589 PPPAPGDSTTPPPPP-----------------PPPPPPPPLPGGVCISSPPSLPGGTAIS 631

Query: 245 PPPPICPDS 253
           PPPP+  D+
Sbjct: 632 PPPPLSGDA 640



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 42/144 (29%), Positives = 58/144 (40%), Gaps = 32/144 (22%)

Query: 135 EQNLSDLLSPICEVANNIEQNAQENEN-ESQVSTDESENSRSPGNKSDNIK--------- 184
           EQ L DL      + +  +Q A E ++ E++VS    E ++      D  K         
Sbjct: 501 EQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAA 560

Query: 185 ---PKSAPWNSFLPPPPPMPGPR--LGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSG 239
              P S P  + +PP PP+PG    + P  P    +  PPPPPPPP              
Sbjct: 561 ITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP-------------- 606

Query: 240 PPIIPPPPPIC---PDSLDDADAL 260
           PP  P P  +C   P SL    A+
Sbjct: 607 PPPPPLPGGVCISSPPSLPGGTAI 630



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 28/72 (38%), Positives = 29/72 (40%), Gaps = 15/72 (20%)

Query: 176 PGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPP 235
           PG       P   P    +PPPPP PG   GPG P      PPP    PPP       PP
Sbjct: 699 PGEAGMPPPPPPLPGGPGIPPPPPFPG---GPGIP-----PPPPGMGMPPP-------PP 743

Query: 236 FPSGPPIIPPPP 247
           F  G P  P  P
Sbjct: 744 FGFGVPAAPVLP 755


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 35/78 (44%), Positives = 39/78 (50%), Gaps = 15/78 (19%)

Query: 185 PKSAPWNSFLPPPPPMPG----PRLGPGKPGLKFNGPPPPP--------PPPPPHLLSCW 232
           P S P  + +PPPPP+PG    P   P  PG     PPPPP        PPPPP      
Sbjct: 666 PSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPG 725

Query: 233 L---PPFPSGPPIIPPPP 247
           +   PPFP GP I PPPP
Sbjct: 726 IPPPPPFPGGPGIPPPPP 743



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 39/129 (30%), Positives = 54/129 (41%), Gaps = 27/129 (20%)

Query: 135 EQNLSDLLSPICEVANNIEQNAQENENESQ--VSTDESENSRSP--------GNKSDNIK 184
           E  +S L   + ++   +E   +E  + S   ++   S  SR+P        G+    I 
Sbjct: 538 EAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIP 597

Query: 185 PKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIP 244
           P  AP +S  PPPPP                 PPPPPPPP P  +    PP   G   I 
Sbjct: 598 PPPAPGDSTTPPPPP-----------------PPPPPPPPLPGGVCISSPPSLPGGTAIS 640

Query: 245 PPPPICPDS 253
           PPPP+  D+
Sbjct: 641 PPPPLSGDA 649



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 42/144 (29%), Positives = 58/144 (40%), Gaps = 32/144 (22%)

Query: 135 EQNLSDLLSPICEVANNIEQNAQENEN-ESQVSTDESENSRSPGNKSDNIK--------- 184
           EQ L DL      + +  +Q A E ++ E++VS    E ++      D  K         
Sbjct: 510 EQKLQDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAA 569

Query: 185 ---PKSAPWNSFLPPPPPMPGPR--LGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSG 239
              P S P  + +PP PP+PG    + P  P    +  PPPPPPPP              
Sbjct: 570 ITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP-------------- 615

Query: 240 PPIIPPPPPIC---PDSLDDADAL 260
           PP  P P  +C   P SL    A+
Sbjct: 616 PPPPPLPGGVCISSPPSLPGGTAI 639



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 28/72 (38%), Positives = 29/72 (40%), Gaps = 15/72 (20%)

Query: 176 PGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPP 235
           PG       P   P    +PPPPP PG   GPG P      PPP    PPP       PP
Sbjct: 708 PGEAGMPPPPPPLPGGPGIPPPPPFPG---GPGIP-----PPPPGMGMPPP-------PP 752

Query: 236 FPSGPPIIPPPP 247
           F  G P  P  P
Sbjct: 753 FGFGVPAAPVLP 764


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 31/59 (52%), Positives = 34/59 (57%), Gaps = 5/59 (8%)

Query: 194 LPPPPPMPGPRLG-PGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICP 251
           LPPPPP P P+ G P  P L    PPPPPPPPP H      PP    PP +PPPP + P
Sbjct: 690 LPPPPPPPPPQPGFPMPPPL----PPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPP 744



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 41/125 (32%), Positives = 58/125 (46%), Gaps = 25/125 (20%)

Query: 140 DLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPK---------SAPW 190
           DL+      +  +++  Q +  + ++S DE  ++  P   +D  KP          +AP 
Sbjct: 616 DLVGDRTPTSEKMDEGQQSSGEDMEISDDEMPSA--PITSADCPKPMVVTPGAAAVAAP- 672

Query: 191 NSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPP------PPHLLSCWLPPFPSGPPIIP 244
            S L P  P+P P   PG P L    PPPPPPPP      PP L     PP P+ P +  
Sbjct: 673 -SVLAPTLPLPPP---PGFPPLP---PPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTV 725

Query: 245 PPPPI 249
           PPPP+
Sbjct: 726 PPPPL 730



 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 28/68 (41%), Positives = 32/68 (47%), Gaps = 13/68 (19%)

Query: 185 PKSAPWNSF-LPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPII 243
           P   P   F +PPP P P P   P  P +    PPPP P PP       +PP    PPI+
Sbjct: 695 PPPPPQPGFPMPPPLPPPPPPPPPAHPAVTV--PPPPLPAPP------GVPP----PPIL 742

Query: 244 PPPPPICP 251
           PP PP  P
Sbjct: 743 PPLPPFPP 750



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 25/71 (35%), Positives = 29/71 (40%), Gaps = 3/71 (4%)

Query: 175 SPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLP 234
           +PG KS    P   P   F PPP           +   +F   P PPP PP   L+   P
Sbjct: 390 APGFKSA-FSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKP 448

Query: 235 PFPSGPPIIPP 245
             P GPP  PP
Sbjct: 449 GTPPGPP--PP 457



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 23/60 (38%), Positives = 24/60 (40%), Gaps = 11/60 (18%)

Query: 195  PPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
            P  P  P     P    L F     P PPPP       LPP P  PP   PPPP+ P  L
Sbjct: 1513 PQTPVFPSTH-DPRTVTLDFRNAGIPAPPPP-------LPPQPPPPP---PPPPVEPTKL 1561



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 24/64 (37%), Positives = 29/64 (45%), Gaps = 24/64 (37%)

Query: 191  NSFLP-PPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLP------PFPSGPPII 243
            N+ +P PPPP+P               P PPPPPPPP +    LP       +PS    I
Sbjct: 1533 NAGIPAPPPPLP---------------PQPPPPPPPPPVEPTKLPFKELDNQWPS--EAI 1575

Query: 244  PPPP 247
            PP P
Sbjct: 1576 PPGP 1579



 Score = 32.3 bits (72), Expect = 0.51
 Identities = 30/114 (26%), Positives = 38/114 (33%), Gaps = 18/114 (15%)

Query: 160  ENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPR------LGPGKPGLK 213
            E E  + T+       P    +   P      +    PP  PG        L P  P  +
Sbjct: 1188 EEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKE 1247

Query: 214  FNGPPPPPP-----------PPPPHLLSCWL-PPFPSGPPIIPPPPPICPDSLD 255
                PP  P           P PP +L   L PP P   P  PP PP  P++ D
Sbjct: 1248 VEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSPPPEPETTD 1301



 Score = 32.3 bits (72), Expect = 0.51
 Identities = 20/57 (35%), Positives = 24/57 (42%), Gaps = 8/57 (14%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPIC 250
            LP  PP+P PR  P +P      P PPP P         +PP P      P  P +C
Sbjct: 1276 LPLQPPLPPPR--PPRP------PSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLC 1324



 Score = 30.0 bits (66), Expect = 2.5
 Identities = 15/33 (45%), Positives = 16/33 (48%), Gaps = 5/33 (15%)

Query: 216  GPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPP 248
            G P PPPP PP       PP P  PP+ P   P
Sbjct: 1535 GIPAPPPPLPPQP-----PPPPPPPPVEPTKLP 1562



 Score = 29.6 bits (65), Expect = 3.3
 Identities = 23/62 (37%), Positives = 25/62 (40%), Gaps = 2/62 (3%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDS 253
            LP P P+P P   P     +   P P PP  P  L SC  PP     P  P   P    S
Sbjct: 1431 LPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASC--PPPMKRKPGRPRRSPPSMLS 1488

Query: 254  LD 255
            LD
Sbjct: 1489 LD 1490


>gi|126723060 zinc finger CCCH-type containing 4 [Homo sapiens]
          Length = 1303

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 33/110 (30%), Positives = 46/110 (41%), Gaps = 11/110 (10%)

Query: 161 NESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPP 220
           ++++   ++ +       +  N  PK  P    LP PP  PGP+      G    G PPP
Sbjct: 484 DDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPQAPTSPNGRPMQGGPPP 543

Query: 221 PPPPPPHLLSCWLPPFPSGPPIIPPP--PPICPDSLDDADALGSMLISWY 268
           PPPPPP          P GPP +P P   P+ P  L   D     + S +
Sbjct: 544 PPPPPPP---------PPGPPQMPMPVHEPLSPQQLQQQDMYNKKIPSLF 584



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 20/41 (48%), Positives = 21/41 (51%), Gaps = 13/41 (31%)

Query: 216 GPPPPPP---PPPPHLLSCWLPPFPSGPPIIPPPPPICPDS 253
           G PPPPP   PPPP       PP    PP  P PPP  PD+
Sbjct: 6   GTPPPPPSESPPPPS------PP----PPSTPSPPPCSPDA 36



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 15/81 (18%)

Query: 195 PPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHL---------LSCWLPPFPS---GPPI 242
           PP P  PGP +GP  P     GP  P   P  H          +   +P  P    GPP+
Sbjct: 608 PPGPMGPGPNMGPPGP---MGGPMHPDMHPDMHPDMHPDMHADMHADMPMGPGMNPGPPM 664

Query: 243 IPPPPPICPDSLDDADALGSM 263
            P  PP+ P    D+   G M
Sbjct: 665 GPGGPPMMPYGPGDSPHSGMM 685



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 19/48 (39%), Positives = 20/48 (41%), Gaps = 8/48 (16%)

Query: 207 PGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
           PG P    +  PPPP PPPP          PS PP  P   P  P  L
Sbjct: 5   PGTPPPPPSESPPPPSPPPPST--------PSPPPCSPDARPATPHLL 44



 Score = 33.5 bits (75), Expect = 0.23
 Identities = 20/64 (31%), Positives = 26/64 (40%), Gaps = 13/64 (20%)

Query: 195 PPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
           PPPPP   P             PP PPPP  P    C     P+ P ++    P+ PD  
Sbjct: 8   PPPPPSESPP------------PPSPPPPSTPSPPPCSPDARPATPHLLHHRLPL-PDDR 54

Query: 255 DDAD 258
           +D +
Sbjct: 55  EDGE 58



 Score = 32.7 bits (73), Expect = 0.39
 Identities = 35/130 (26%), Positives = 43/130 (33%), Gaps = 49/130 (37%)

Query: 174 RSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPG------------------------- 208
           R PG ++    P   P     PPPPP P P  GP                          
Sbjct: 522 RPPGPQAPT-SPNGRPMQGGPPPPPPPPPPPPGPPQMPMPVHEPLSPQQLQQQDMYNKKI 580

Query: 209 ----------------KPGLKFNGP--PPPPPPPPPHLLSCWLPPFPSGPPIIPP-PPPI 249
                           K G++F GP  PP P  P P++     PP P G P+ P   P +
Sbjct: 581 PSLFEIVVRPTGQLAEKLGVRFPGPGGPPGPMGPGPNM----GPPGPMGGPMHPDMHPDM 636

Query: 250 CPDSLDDADA 259
            PD   D  A
Sbjct: 637 HPDMHPDMHA 646



 Score = 30.0 bits (66), Expect = 2.5
 Identities = 18/45 (40%), Positives = 23/45 (51%), Gaps = 6/45 (13%)

Query: 188 APWNSFLPPPPPM-PGPRLGPGKPGLKFNGPPPPP-----PPPPP 226
           A  ++ +P  P M PGP +GPG P +   GP   P     PP PP
Sbjct: 646 ADMHADMPMGPGMNPGPPMGPGGPPMMPYGPGDSPHSGMMPPIPP 690


>gi|5032113 survival motor neuron domain containing 1 [Homo sapiens]
          Length = 238

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 33/94 (35%), Positives = 48/94 (51%), Gaps = 2/94 (2%)

Query: 92  WKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANN 151
           WKVGDKC A+WSEDG  Y A I  ID +  T  + + GYGN E   L + L P+ E    
Sbjct: 73  WKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLN-LKPVEEGRKA 131

Query: 152 IEQNAQENENESQVSTDESENSRSPG-NKSDNIK 184
            E +  +  ++ ++   + E  +     K+  IK
Sbjct: 132 KEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIK 165


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 31/63 (49%), Positives = 37/63 (58%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P + IPPP
Sbjct: 1052 IPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPP 1110

Query: 247  PPI 249
            PP+
Sbjct: 1111 PPL 1113



 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 31/63 (49%), Positives = 37/63 (58%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P + IPPP
Sbjct: 1096 IPPPPPLPGVGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPP 1154

Query: 247  PPI 249
            PP+
Sbjct: 1155 PPL 1157



 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 29/62 (46%), Positives = 36/62 (58%), Gaps = 6/62 (9%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPP-----PPPPPHLLSCWLPPFPSGPPI-IPPPP 247
            +PPPPP+PG  + P  P  +   PPPPP      PPPP L    +PP P  P + IPPPP
Sbjct: 1129 IPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPP 1188

Query: 248  PI 249
            P+
Sbjct: 1189 PL 1190



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 33/71 (46%), Positives = 40/71 (56%), Gaps = 13/71 (18%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPIIP--- 244
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P+ PP+ P   
Sbjct: 1173 IPPPPPLPGVGIPPPPP-LPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPA-PPLPPPGT 1230

Query: 245  --PPPPICPDS 253
              PPPP+ P S
Sbjct: 1231 GIPPPPLLPVS 1241



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 975  IPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1033

Query: 247  PPI 249
            PP+
Sbjct: 1034 PPL 1036



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 986  IPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1044

Query: 247  PPI 249
            PP+
Sbjct: 1045 PPL 1047



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 997  IPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1055

Query: 247  PPI 249
            PP+
Sbjct: 1056 PPL 1058



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 1008 IPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1066

Query: 247  PPI 249
            PP+
Sbjct: 1067 PPL 1069



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 1019 IPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1077

Query: 247  PPI 249
            PP+
Sbjct: 1078 PPL 1080



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 1030 IPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1088

Query: 247  PPI 249
            PP+
Sbjct: 1089 PPL 1091



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 1041 IPPPPPLPGAGI-PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1099

Query: 247  PPI 249
            PP+
Sbjct: 1100 PPL 1102



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 1074 IPPPPPLPGAGI-PPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPP 1132

Query: 247  PPI 249
            PP+
Sbjct: 1133 PPL 1135



 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 1118 IPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPP 1176

Query: 247  PPI 249
            PP+
Sbjct: 1177 PPL 1179



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 1063 IPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAGIPPP 1121

Query: 247  PPI 249
            PP+
Sbjct: 1122 PPL 1124



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 1085 IPPPPPLPGAGIPPPPP-LPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1143

Query: 247  PPI 249
            PP+
Sbjct: 1144 PPL 1146



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 953  IPPPPPLPGAGI-PLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1011

Query: 247  PPI 249
            PP+
Sbjct: 1012 PPL 1014



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 31/63 (49%), Positives = 36/63 (57%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 1107 IPPPPPLPGAGIPPPPP-LPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP 1165

Query: 247  PPI 249
            PP+
Sbjct: 1166 PPL 1168



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 30/63 (47%), Positives = 35/63 (55%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +PPPPP+PG  + P  P L   G P PPP      PPPP L    +PP P  P   IPPP
Sbjct: 942  IPPPPPLPGAAIPPPPP-LPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1000

Query: 247  PPI 249
            PP+
Sbjct: 1001 PPL 1003



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 30/63 (47%), Positives = 35/63 (55%), Gaps = 8/63 (12%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLPPFPSGPPI-IPPP 246
            +P PPP+PG  + P  P L   G PPPPP      PPPP L    +PP P  P   IPPP
Sbjct: 964  IPLPPPLPGAGI-PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPP 1022

Query: 247  PPI 249
            PP+
Sbjct: 1023 PPL 1025



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 30/63 (47%), Positives = 35/63 (55%), Gaps = 8/63 (12%)

Query: 194 LPPPPPMPGPRLGPGKPGLKFNGPPPPPP------PPPPHLLSCWLP-PFPSGPPIIPPP 246
           +PPPPP+PG  + P  P L   G PPPPP      PPPP L    +P P P     IPPP
Sbjct: 920 IPPPPPLPGAGILP-LPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPP 978

Query: 247 PPI 249
           PP+
Sbjct: 979 PPL 981



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 27/68 (39%), Positives = 34/68 (50%), Gaps = 13/68 (19%)

Query: 194  LPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFP----SGPPIIP----- 244
            +PPPPP+PG  + P  P      PP P PP PP      +PP P    SGPP++P     
Sbjct: 1195 IPPPPPLPGAGIPPPPPLPGMGIPPAPAPPLPPP--GTGIPPPPLLPVSGPPLLPQVGSS 1252

Query: 245  --PPPPIC 250
              P P +C
Sbjct: 1253 TLPTPQVC 1260



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 32/71 (45%), Positives = 36/71 (50%), Gaps = 16/71 (22%)

Query: 195 PPPPPMPG---PRLG----PGKPGLKFNG--PPPPPP------PPPPHLLSCWLPPFPSG 239
           PPPPP+PG   P L     P  P L+     PPPPPP      PPPP L    + P P  
Sbjct: 878 PPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPPL 937

Query: 240 PPI-IPPPPPI 249
           P   IPPPPP+
Sbjct: 938 PGAGIPPPPPL 948



 Score = 48.5 bits (114), Expect = 7e-06
 Identities = 29/74 (39%), Positives = 34/74 (45%), Gaps = 20/74 (27%)

Query: 194 LPPPPPMPGPRLGPGKPGLKFNGPPPPP--------------PPPPPHLLSCWLPPFPSG 239
           +P PPP+P        PGL    PPPPP              P PPP   +  LPP P  
Sbjct: 855 IPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPP-- 912

Query: 240 PPI----IPPPPPI 249
           PP+    IPPPPP+
Sbjct: 913 PPLPGAGIPPPPPL 926



 Score = 36.6 bits (83), Expect = 0.027
 Identities = 30/107 (28%), Positives = 35/107 (32%), Gaps = 50/107 (46%)

Query: 195 PPPPPMPGPRLGPGKPGLK------------------------FNGPPPPP--------- 221
           PPPPP      G G+PG +                         N P PPP         
Sbjct: 810 PPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSS 869

Query: 222 -------PPPPPHLLSCWLPPFPS----------GPPIIPPPPPICP 251
                  PPPPP L    +P  PS          G  ++PPPPP  P
Sbjct: 870 MPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLP 916


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 30/60 (50%), Positives = 33/60 (55%), Gaps = 8/60 (13%)

Query: 195 PPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPI---IPPPPPICP 251
           PPPPP+P     PG        PPPP PPPPP L S   PP P  PP+   +PPPPP  P
Sbjct: 314 PPPPPLP-----PGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPP 368



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 41/125 (32%), Positives = 51/125 (40%), Gaps = 23/125 (18%)

Query: 147 EVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSA--PWNSFL-------PPP 197
           E    +E+  QE E + Q+  ++ E  R     S    P S   P NS L       P  
Sbjct: 233 ERLERLERERQERERQEQLEREQLEWERER-RISSAAAPASVETPLNSVLGDSSASEPGL 291

Query: 198 PPMPGPRLGPGKPGLKFN--GPPPPPP-PPPPHLLSCWLPPFP----------SGPPIIP 244
                P   P + G+      PPPPPP PP P   S  LPP P          +GPP  P
Sbjct: 292 QAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPP 351

Query: 245 PPPPI 249
           PPPP+
Sbjct: 352 PPPPL 356



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 25/55 (45%), Positives = 27/55 (49%), Gaps = 7/55 (12%)

Query: 176 PGNKSDNIKPKSAPWNSFLPPPPPMP--GPRLGPGKPGLKFNGPPPPPPPPPPHL 228
           P   S  + P   P     PPPPP+P  GP   P  P L    PPPPPPPP P L
Sbjct: 323 PAQASVALPPPPGP-----PPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPL 372


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 59.3 bits (142), Expect = 4e-09
 Identities = 30/60 (50%), Positives = 33/60 (55%), Gaps = 8/60 (13%)

Query: 195 PPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPI---IPPPPPICP 251
           PPPPP+P     PG        PPPP PPPPP L S   PP P  PP+   +PPPPP  P
Sbjct: 314 PPPPPLP-----PGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPP 368



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 41/125 (32%), Positives = 51/125 (40%), Gaps = 23/125 (18%)

Query: 147 EVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSA--PWNSFL-------PPP 197
           E    +E+  QE E + Q+  ++ E  R     S    P S   P NS L       P  
Sbjct: 233 ERLERLERERQERERQEQLEREQLEWERER-RISSAAAPASVETPLNSVLGDSSASEPGL 291

Query: 198 PPMPGPRLGPGKPGLKFN--GPPPPPP-PPPPHLLSCWLPPFP----------SGPPIIP 244
                P   P + G+      PPPPPP PP P   S  LPP P          +GPP  P
Sbjct: 292 QAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPP 351

Query: 245 PPPPI 249
           PPPP+
Sbjct: 352 PPPPL 356



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 25/55 (45%), Positives = 27/55 (49%), Gaps = 7/55 (12%)

Query: 176 PGNKSDNIKPKSAPWNSFLPPPPPMP--GPRLGPGKPGLKFNGPPPPPPPPPPHL 228
           P   S  + P   P     PPPPP+P  GP   P  P L    PPPPPPPP P L
Sbjct: 323 PAQASVALPPPPGP-----PPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPL 372


>gi|32880208 diaphanous homolog 3 isoform b [Homo sapiens]
          Length = 849

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 16/99 (16%)

Query: 153 EQNAQENENESQVSTDESENSRSPGNKSDNIKP--KSAPWNSFLPPPPPMPGPRLGPGKP 210
           ++ A+ NE ++++   +S+    P + +  + P  +    +S LPPPPP+P         
Sbjct: 269 KKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSG------- 321

Query: 211 GLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPI 249
                G PPPPPPPPP  L     PF SGP  +PPPPP+
Sbjct: 322 ----GGVPPPPPPPPPPPLPGMRMPF-SGP--VPPPPPL 353



 Score = 33.5 bits (75), Expect = 0.23
 Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 21/94 (22%)

Query: 167 TDESENSRSPGNKSDNIKPKSAPWNSF------LPPPPPMPGPRLGPGKPGLKFNGPPPP 220
           TD  E       K   I    A   +F      LP    +P P   P K G   +   PP
Sbjct: 258 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP---PSKEGGTGHSALPP 314

Query: 221 PPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
           PPP             PSG  + PPPPP  P  L
Sbjct: 315 PPP------------LPSGGGVPPPPPPPPPPPL 336


>gi|110225351 diaphanous homolog 3 isoform a [Homo sapiens]
          Length = 1193

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 35/99 (35%), Positives = 52/99 (52%), Gaps = 16/99 (16%)

Query: 153 EQNAQENENESQVSTDESENSRSPGNKSDNIKP--KSAPWNSFLPPPPPMPGPRLGPGKP 210
           ++ A+ NE ++++   +S+    P + +  + P  +    +S LPPPPP+P         
Sbjct: 532 KKEAKINELQAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSG------- 584

Query: 211 GLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPI 249
                G PPPPPPPPP  L     PF SGP  +PPPPP+
Sbjct: 585 ----GGVPPPPPPPPPPPLPGMRMPF-SGP--VPPPPPL 616



 Score = 33.5 bits (75), Expect = 0.23
 Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 21/94 (22%)

Query: 167 TDESENSRSPGNKSDNIKPKSAPWNSF------LPPPPPMPGPRLGPGKPGLKFNGPPPP 220
           TD  E       K   I    A   +F      LP    +P P   P K G   +   PP
Sbjct: 521 TDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLP---PSKEGGTGHSALPP 577

Query: 221 PPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
           PPP             PSG  + PPPPP  P  L
Sbjct: 578 PPP------------LPSGGGVPPPPPPPPPPPL 599


>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
          Length = 1240

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 35/72 (48%), Positives = 38/72 (52%), Gaps = 21/72 (29%)

Query: 195 PPPPPMPG--------PRLGPGKPG-LKFNGPPPPP------PPPPPHLLSCWLPPFPSG 239
           PPPPP+PG        P L P  PG  +F  PPPPP      PPPPP LL    P    G
Sbjct: 458 PPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLL----PGMGWG 513

Query: 240 PPIIPPPPPICP 251
           PP  PPPPP+ P
Sbjct: 514 PP--PPPPPLLP 523



 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 29/74 (39%), Positives = 37/74 (50%), Gaps = 11/74 (14%)

Query: 184 KPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPI- 242
           +P++    +  PPPPP P     P  PG     PPPPPPPP P + +  LP  P  PP+ 
Sbjct: 410 QPRALEQQASTPPPPPPP-----PLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLP 464

Query: 243 -----IPPPPPICP 251
                 PP PP+ P
Sbjct: 465 GLGAMAPPAPPLPP 478



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 30/74 (40%), Positives = 32/74 (43%), Gaps = 12/74 (16%)

Query: 185 PKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPP--- 241
           P   P +S  PPPPP P P    G   L     P  PPPPP   L    PP P  PP   
Sbjct: 427 PPLLPGSSAEPPPPPPPPPLPSVGAKAL-----PTAPPPPPLPGLGAMAPPAPPLPPPLP 481

Query: 242 ----IIPPPPPICP 251
                +PPPPP  P
Sbjct: 482 GSCEFLPPPPPPLP 495



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 33/72 (45%), Positives = 37/72 (51%), Gaps = 17/72 (23%)

Query: 195 PPPPPMPGPRLG----------PGKPGLKFNGPPPPP-PPPPPHLLSC-WLPPFPSGPPI 242
           PPPPP P P +G          P  PGL    PP PP PPP P   SC +LPP P   P 
Sbjct: 439 PPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPG--SCEFLPPPPPPLPG 496

Query: 243 I---PPPPPICP 251
           +   PPPPP+ P
Sbjct: 497 LGCPPPPPPLLP 508



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 21/45 (46%), Positives = 22/45 (48%)

Query: 195 PPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSG 239
           PPPPP+PG    P  P L       PPPPPPP L     PP   G
Sbjct: 489 PPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGG 533


>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
          Length = 1249

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 35/72 (48%), Positives = 38/72 (52%), Gaps = 21/72 (29%)

Query: 195 PPPPPMPG--------PRLGPGKPG-LKFNGPPPPP------PPPPPHLLSCWLPPFPSG 239
           PPPPP+PG        P L P  PG  +F  PPPPP      PPPPP LL    P    G
Sbjct: 458 PPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLL----PGMGWG 513

Query: 240 PPIIPPPPPICP 251
           PP  PPPPP+ P
Sbjct: 514 PP--PPPPPLLP 523



 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 29/74 (39%), Positives = 37/74 (50%), Gaps = 11/74 (14%)

Query: 184 KPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPI- 242
           +P++    +  PPPPP P     P  PG     PPPPPPPP P + +  LP  P  PP+ 
Sbjct: 410 QPRALEQQASTPPPPPPP-----PLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLP 464

Query: 243 -----IPPPPPICP 251
                 PP PP+ P
Sbjct: 465 GLGAMAPPAPPLPP 478



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 30/74 (40%), Positives = 32/74 (43%), Gaps = 12/74 (16%)

Query: 185 PKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPP--- 241
           P   P +S  PPPPP P P    G   L     P  PPPPP   L    PP P  PP   
Sbjct: 427 PPLLPGSSAEPPPPPPPPPLPSVGAKAL-----PTAPPPPPLPGLGAMAPPAPPLPPPLP 481

Query: 242 ----IIPPPPPICP 251
                +PPPPP  P
Sbjct: 482 GSCEFLPPPPPPLP 495



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 33/72 (45%), Positives = 37/72 (51%), Gaps = 17/72 (23%)

Query: 195 PPPPPMPGPRLG----------PGKPGLKFNGPPPPP-PPPPPHLLSC-WLPPFPSGPPI 242
           PPPPP P P +G          P  PGL    PP PP PPP P   SC +LPP P   P 
Sbjct: 439 PPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPLPG--SCEFLPPPPPPLPG 496

Query: 243 I---PPPPPICP 251
           +   PPPPP+ P
Sbjct: 497 LGCPPPPPPLLP 508



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 21/45 (46%), Positives = 22/45 (48%)

Query: 195 PPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSG 239
           PPPPP+PG    P  P L       PPPPPPP L     PP   G
Sbjct: 489 PPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGG 533


>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
           sapiens]
          Length = 505

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 30/68 (44%), Positives = 33/68 (48%), Gaps = 10/68 (14%)

Query: 195 PPPPPMPGPRLGPGKPGLKFNGPPPPP---------PPPPPHLLSCWLPPFPSGPPIIPP 245
           PPPPP P    GP  P  +  G PPPP         PPPPP   S  +PP P    + PP
Sbjct: 287 PPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPP-PPPNRMYPP 345

Query: 246 PPPICPDS 253
           PPP  P S
Sbjct: 346 PPPALPSS 353



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 32/83 (38%), Positives = 36/83 (43%), Gaps = 12/83 (14%)

Query: 185 PKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPP--------PPPPPPHLLSCW---- 232
           P  AP  +  PPPP  P   + P  P   +  PPP         PPPPPP +L       
Sbjct: 314 PSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAP 373

Query: 233 LPPFPSGPPIIPPPPPICPDSLD 255
            PP P  PP  PPPPP  P   D
Sbjct: 374 PPPPPPPPPPGPPPPPGLPSDGD 396



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 32/83 (38%), Positives = 35/83 (42%), Gaps = 11/83 (13%)

Query: 176 PGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPP-------PPPHL 228
           P ++     P   P NS  PPPPP  G    P  P       PPPPPP       PPP  
Sbjct: 281 PPSRGGPPPPPPPPHNSG-PPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPP 339

Query: 229 LSCWLPP---FPSGPPIIPPPPP 248
              + PP    PS  P  PPPPP
Sbjct: 340 NRMYPPPPPALPSSAPSGPPPPP 362



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 38/122 (31%), Positives = 53/122 (43%), Gaps = 19/122 (15%)

Query: 137 NLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPP 196
           NL   L  + ++    E   ++ E  S+V  D  E +       + ++ ++ P     PP
Sbjct: 227 NLDPELKNLFDMCGISEAQLKDRET-SKVIYDFIEKTGGVEAVKNELRRQAPP-----PP 280

Query: 197 PPPMPGPRLGPGKPGLKFNGPPPPP-------PPPPPHL--LSCWLPPFPSGPPI-IPPP 246
           PP   GP   P  P    N  PPPP       PPPPP     +   PP PS P + +PPP
Sbjct: 281 PPSRGGP---PPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPP 337

Query: 247 PP 248
           PP
Sbjct: 338 PP 339


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 38/106 (35%), Positives = 47/106 (44%), Gaps = 23/106 (21%)

Query: 171 ENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLS 230
           +N  SP +  D+++          PPP P P  +  P         PPPPPPPPPP+L S
Sbjct: 571 QNQASPCSSGDDMEISDDDRGGS-PPPAPTPPQQPPP---------PPPPPPPPPPYLAS 620

Query: 231 C-----------WLPPFPSG--PPIIPPPPPICPDSLDDADALGSM 263
                        LPP P G  PP  PPPPP  P   D  ++L  M
Sbjct: 621 LPLGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELM 666



 Score = 36.6 bits (83), Expect = 0.027
 Identities = 50/213 (23%), Positives = 75/213 (35%), Gaps = 32/213 (15%)

Query: 64   GKPKTTPKRKPAKKNKSQKKNTAA--------SLQQWKVGDKCSAIWSEDGCIYPATIAS 115
            G+P T P ++  ++ K+Q K+  +           Q    +K      ED        A 
Sbjct: 935  GRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAV 994

Query: 116  IDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRS 175
               K+ET V      G  EE + S   S   +     +  +    + S  S+  S +S S
Sbjct: 995  DTTKKETEV----SDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSS 1050

Query: 176  PGNKSDNIKPKS---------APWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPP 226
              + S + +  S         A   S  PPP  +P P   P +  +       P  P P 
Sbjct: 1051 SSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPLPE 1110

Query: 227  HLLSCWLPPFPSGP--------PIIPPPPPICP 251
               S   P  P+GP        P+ PP PP  P
Sbjct: 1111 QEAS---PARPAGPTEESPPSAPLRPPEPPAGP 1140



 Score = 34.7 bits (78), Expect = 0.10
 Identities = 27/117 (23%), Positives = 40/117 (34%), Gaps = 20/117 (17%)

Query: 149  ANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLP------------P 196
            +++   ++  + +    S DE E  R     S +  P+  P  +  P            P
Sbjct: 1045 SSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSP 1104

Query: 197  PPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDS 253
              P+P     P +P       PP  P  PP          P+GPP   P P   P S
Sbjct: 1105 VTPLPEQEASPARPAGPTEESPPSAPLRPPEP--------PAGPPAPAPRPDERPSS 1153



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 19/74 (25%), Positives = 30/74 (40%), Gaps = 20/74 (27%)

Query: 153  EQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGL 212
            E+  +E E E +   +ES +S S  +    ++ +S                     +   
Sbjct: 1359 EEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSL--------------------RSHA 1398

Query: 213  KFNGPPPPPPPPPP 226
            +   PPPPPPPPPP
Sbjct: 1399 RRRRPPPPPPPPPP 1412



 Score = 32.7 bits (73), Expect = 0.39
 Identities = 25/82 (30%), Positives = 34/82 (41%), Gaps = 11/82 (13%)

Query: 169  ESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPH- 227
            E+  +R  G   ++  P SAP    L PP P  GP     +P  + + P P  PPP    
Sbjct: 1112 EASPARPAGPTEES--PPSAP----LRPPEPPAGPPAPAPRPDERPSSPIPLLPPPKKRR 1165

Query: 228  ----LLSCWLPPFPSGPPIIPP 245
                  +  + P P  PP  PP
Sbjct: 1166 KTVSFSAIEVVPAPEPPPATPP 1187


>gi|169163027 PREDICTED: similar to Putative acrosin-like protease
           [Homo sapiens]
          Length = 355

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 51/145 (35%), Positives = 60/145 (41%), Gaps = 26/145 (17%)

Query: 117 DFKRETCVVVY-----TGYGNREEQNLSDLLSPICE-VANNIEQNAQENENESQVSTDES 170
           D K   CVVV       G    +   +     P    +A+ I  NA       Q +T   
Sbjct: 182 DSKESACVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRM---IQSATPPP 238

Query: 171 ENSRSPGNKSDNIKPKSA--PWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHL 228
             +R P  +     P SA  PW  F PPP P+P PR    +P      PPP PPPPPP  
Sbjct: 239 PTTRPPPIRPPFSHPLSAHLPWY-FQPPPRPLP-PRPPAAQPR-----PPPSPPPPPPP- 290

Query: 229 LSCWLPPFPSGPPIIPPPPPICPDS 253
                PP P  PP  PPPPP  P S
Sbjct: 291 -----PPSPLPPP--PPPPPPTPSS 308



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 26/65 (40%), Positives = 27/65 (41%), Gaps = 11/65 (16%)

Query: 195 PPPPPMPGPRLGPGKPGLKFNGP---PPPPPPPPPHLLSCWLPPF--PSGPPIIPPPPPI 249
           PPP   P P   P    L  + P    PPP P PP       PP   P  PP  PPPPP 
Sbjct: 237 PPPTTRPPPIRPPFSHPLSAHLPWYFQPPPRPLPPR------PPAAQPRPPPSPPPPPPP 290

Query: 250 CPDSL 254
            P  L
Sbjct: 291 PPSPL 295



 Score = 35.4 bits (80), Expect = 0.060
 Identities = 18/40 (45%), Positives = 19/40 (47%), Gaps = 8/40 (20%)

Query: 195 PPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLP 234
           P PPP P P   P         PPPPPPPPP    +  LP
Sbjct: 282 PSPPPPPPPPPSP--------LPPPPPPPPPTPSSTTKLP 313


>gi|150417989 cyclin K isoform 1 [Homo sapiens]
          Length = 580

 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 34/89 (38%), Positives = 37/89 (41%), Gaps = 12/89 (13%)

Query: 185 PKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLL------SCWLPPFPS 238
           P   P  SF PP  P P P   P  P    N PPPPP  PP H +         LPP   
Sbjct: 486 PVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASY 545

Query: 239 GPPIIPP------PPPICPDSLDDADALG 261
            PP +PP      PPPI P  +     LG
Sbjct: 546 PPPAVPPGGQPPVPPPIPPPGMPPVGGLG 574



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 26/58 (44%), Positives = 30/58 (51%), Gaps = 8/58 (13%)

Query: 195 PPPPPMPGPRLGPGKPGLKFNGPPPPP--PPPPPHLLSCWLPPFPSGPP--IIPPPPP 248
           PPPPP+P P      P +    PPP P  PPPPP     + PP P  PP   +PP PP
Sbjct: 482 PPPPPVPPPPASFPPPAI----PPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPP 535



 Score = 41.6 bits (96), Expect = 8e-04
 Identities = 23/52 (44%), Positives = 24/52 (46%), Gaps = 2/52 (3%)

Query: 197 PPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPP 248
           PP    P   P  P +    PPPPP PPPP   S   P  P   P  PPPPP
Sbjct: 462 PPAYGPPAHLPYHPHVYPPNPPPPPVPPPP--ASFPPPAIPPPTPGYPPPPP 511



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 25/65 (38%), Positives = 29/65 (44%), Gaps = 15/65 (23%)

Query: 196 PPPPMP-GPRLGPGKPGLKFNGPPPPPPPPP--------PHLLSCWLPPFPSGPPIIPPP 246
           PP  +P  P + P  P      PPPP PPPP        P     + PP P+  P  PPP
Sbjct: 467 PPAHLPYHPHVYPPNP------PPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPP 520

Query: 247 PPICP 251
           PP  P
Sbjct: 521 PPRLP 525



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 27/101 (26%), Positives = 35/101 (34%), Gaps = 4/101 (3%)

Query: 154 QNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLK 213
           Q   + +  +Q     S    SP      +       N    PPPP   P++    P L 
Sbjct: 308 QQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKI-PKIETTHPPLP 366

Query: 214 FNGPPPPPPPPPPHLLSCWLPPFP---SGPPIIPPPPPICP 251
              PPP   PP    L    PP P   +  P +  PPP  P
Sbjct: 367 PAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHP 407



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 26/84 (30%), Positives = 30/84 (35%), Gaps = 31/84 (36%)

Query: 195 PPPPP-------------MPGPRLGPGKPGLKFNGP----------PPPPPPPPPHLLSC 231
           PPPPP             M G      +  +K  GP          PP   P  PH+   
Sbjct: 421 PPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHV--- 477

Query: 232 WLPPFPSGPPIIPP----PPPICP 251
             PP P  PP+ PP    PPP  P
Sbjct: 478 -YPPNPPPPPVPPPPASFPPPAIP 500



 Score = 28.9 bits (63), Expect = 5.7
 Identities = 27/107 (25%), Positives = 37/107 (34%), Gaps = 9/107 (8%)

Query: 158 ENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGP 217
           +    SQ S       + P   +   +P   P      P  P    R     P  +    
Sbjct: 289 QQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAA 348

Query: 218 PPPPPPPPPHLLSCWLPPFPSGPPIIPPP---PPICPDSLDDADALG 261
            PPPP  P   +    PP    PP  PPP   PP+   +L +A+  G
Sbjct: 349 EPPPPKIPK--IETTHPPL---PPAHPPPDRKPPLAA-ALGEAEPPG 389


>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
           subunit [Homo sapiens]
          Length = 551

 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 28/56 (50%), Positives = 31/56 (55%), Gaps = 7/56 (12%)

Query: 196 PPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICP 251
           PPPP+PG    PG P  +  GPPPPP P PP       PP P GPP+   PPP  P
Sbjct: 296 PPPPVPGYGPPPGPPPPQ-QGPPPPPGPFPPR------PPGPLGPPLTLAPPPHLP 344



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 31/71 (43%), Positives = 32/71 (45%), Gaps = 7/71 (9%)

Query: 185 PKSAPWNSFLPPP---PPMPGPRLGPGK--PGLKFNGPP--PPPPPPPPHLLSCWLPPFP 237
           P   P    LPPP   PP  G R  P    PG  F  PP  P PP PPP +     PP P
Sbjct: 250 PGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGP 309

Query: 238 SGPPIIPPPPP 248
             P   PPPPP
Sbjct: 310 PPPQQGPPPPP 320



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 28/60 (46%), Positives = 33/60 (55%), Gaps = 9/60 (15%)

Query: 196 PPPPMPGPRLGPGKPGLKFNGPP-PPPPPPPPHLLSCWLPPFPSGPP---IIPPPPPICP 251
           PPPP P  +  P +P L   GPP PP PPPP  +    LPP  +GPP     PPPP + P
Sbjct: 226 PPPPFPAGQTPP-RPPLGPPGPPGPPGPPPPGQV----LPPPLAGPPNRGDRPPPPVLFP 280



 Score = 45.4 bits (106), Expect = 6e-05
 Identities = 29/74 (39%), Positives = 32/74 (43%), Gaps = 20/74 (27%)

Query: 195 PPPPPMPGPRLGPG--------KPGLKFNGPPPPPPPPPPHLLSCWLPP-----FPS--- 238
           PPPPP P P   PG         P     GPPP  PPP PH+   + PP      P+   
Sbjct: 316 PPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDS 375

Query: 239 -GPPIIPP---PPP 248
            GPP   P   PPP
Sbjct: 376 RGPPPTDPYGRPPP 389



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 36/95 (37%), Positives = 40/95 (42%), Gaps = 29/95 (30%)

Query: 174 RSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPP----PPP------ 223
           R PG       P   P     PP PP+ GP   PG P     GPPPP    PPP      
Sbjct: 216 RFPGPAGPGGPPPPFPAGQ-TPPRPPL-GPPGPPGPP-----GPPPPGQVLPPPLAGPPN 268

Query: 224 ----PPPHLLSCWLPPFPSG-PPIIP----PPPPI 249
               PPP +L    P  P G PP+ P    PPPP+
Sbjct: 269 RGDRPPPPVL---FPGQPFGQPPLGPLPPGPPPPV 300



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 35/112 (31%), Positives = 43/112 (38%), Gaps = 19/112 (16%)

Query: 153 EQNAQENENESQVSTDESENSRS-----PGNKSDNIKPKSAPWNSFLPPPPP----MPGP 203
           +Q   + E +S+ +T   + S       PG  S    P+        P   P     PGP
Sbjct: 161 KQFLSQFEMQSRKTTQSGQMSGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGP 220

Query: 204 RLGPGKPGLKFN-GPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSL 254
             GPG P   F  G  PP PP          PP P GPP  PPP  + P  L
Sbjct: 221 A-GPGGPPPPFPAGQTPPRPPLG--------PPGPPGPPGPPPPGQVLPPPL 263


>gi|11386183 WAS protein family, member 2 [Homo sapiens]
          Length = 498

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 38/101 (37%), Positives = 46/101 (45%), Gaps = 25/101 (24%)

Query: 169 ESENSRSPGNKSDNIKPKSAPWN-----------------SFLPPPPPMPGPRLG--PG- 208
           +S +S SP    DN+ P  A ++                 S + P  P P P LG  PG 
Sbjct: 253 DSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHPPPAPPLGSPPGP 312

Query: 209 KPGLKFNGPPPPPPPPPPHLLSCWLPPFP--SGPPIIPPPP 247
           KPG     PPP PPPPPP ++    PP P   G P  PPPP
Sbjct: 313 KPGF---APPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPP 350



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 39/94 (41%), Positives = 41/94 (43%), Gaps = 29/94 (30%)

Query: 184 KPKSAPWNSFLPPPPPM-----PGPRLGPGKPGLK-------------FNGPPPPPPPP- 224
           KP  AP  +  PPPPPM     P P +G G PG               F  PPPPPPPP 
Sbjct: 313 KPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPA 372

Query: 225 ------PPHLLSCWL----PPFPSGPPIIPPPPP 248
                 PP  LS       PP P  PP  PPPPP
Sbjct: 373 ADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPP 406



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 33/79 (41%), Positives = 33/79 (41%), Gaps = 9/79 (11%)

Query: 175 SPGNKSDNIKPKSAPWNSFLPPPPPMPGPR-----LGPGKPGLKFNGPPPPPPPPPPHLL 229
           SPG       P   P   F  PPPP P P      L P        G PPPPPPPPP   
Sbjct: 343 SPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPP-- 400

Query: 230 SCWLPPF--PSGPPIIPPP 246
               PPF    G P IPPP
Sbjct: 401 GPPPPPFTGADGQPAIPPP 419



 Score = 33.5 bits (75), Expect = 0.23
 Identities = 26/83 (31%), Positives = 27/83 (32%), Gaps = 33/83 (39%)

Query: 196 PPPPMPGPRLGPGKPGLKFNGPPPPP---------------------------PPPPPHL 228
           PPPP       P     + N PPPP                            PPP P L
Sbjct: 247 PPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHPPPAPPL 306

Query: 229 LSCWLPPFPS---GPPIIPPPPP 248
            S   PP P     PP  PPPPP
Sbjct: 307 GS---PPGPKPGFAPPPAPPPPP 326


>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
          Length = 3571

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 33/86 (38%), Positives = 36/86 (41%), Gaps = 11/86 (12%)

Query: 169  ESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMP---GPRLGPGKPGLKFNGPPPPPPPPP 225
            E+ +   P + S    P   P    LPP PP P   GP   P         PPP PPPPP
Sbjct: 1942 EAYDKLYPISPSSPETPPPPPPPPPLPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPPPP 2001

Query: 226  PHLLSCWLPPFPSGPPIIPPPPPICP 251
                    PP P  PP  PPPPP  P
Sbjct: 2002 --------PPPPPPPPPPPPPPPSAP 2019



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 33/84 (39%), Positives = 37/84 (44%), Gaps = 12/84 (14%)

Query: 187  SAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHL---LSCWLPPFPS---GP 240
            S P  +  P PPP P P   P  P      PPPPPP  PP +   +S  LP FPS    P
Sbjct: 1987 STPLQAPPPTPPPPPPPPPPPPPP------PPPPPPSAPPQVQLPVSLDLPLFPSIMMQP 2040

Query: 241  PIIPPPPPICPDSLDDADALGSML 264
               P  PP     L   DAL + L
Sbjct: 2041 VQHPALPPQLALQLPQMDALSADL 2064



 Score = 37.0 bits (84), Expect = 0.021
 Identities = 23/58 (39%), Positives = 26/58 (44%), Gaps = 4/58 (6%)

Query: 173  SRSPG--NKSDNIKPKSAPWNSFLPPPPPMPGPRLG--PGKPGLKFNGPPPPPPPPPP 226
            S  PG    S+ + P  A    F       P   L   P KP L+   PPPPPPPPPP
Sbjct: 3071 SSLPGFPQNSNTLTPPGAGMLGFPTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPPP 3128



 Score = 33.1 bits (74), Expect = 0.30
 Identities = 18/44 (40%), Positives = 18/44 (40%), Gaps = 17/44 (38%)

Query: 187  SAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLS 230
            SAP    L  PPP                 PPPPPPPPP   LS
Sbjct: 3107 SAPTKPLLQTPPP-----------------PPPPPPPPPSSSLS 3133



 Score = 30.0 bits (66), Expect = 2.5
 Identities = 28/81 (34%), Positives = 29/81 (35%), Gaps = 12/81 (14%)

Query: 185  PKSAPWNSFLPPP--PPMPGPRLGPG---------KPGLKFNG-PPPPPPPPPPHLLSCW 232
            P + P    LPP   P M GP   PG          PG    G P      P   L S  
Sbjct: 3050 PTAYPGLPGLPPVLLPGMNGPSSLPGFPQNSNTLTPPGAGMLGFPTSATSSPALSLSSAP 3109

Query: 233  LPPFPSGPPIIPPPPPICPDS 253
              P    PP  PPPPP  P S
Sbjct: 3110 TKPLLQTPPPPPPPPPPPPSS 3130



 Score = 29.6 bits (65), Expect = 3.3
 Identities = 22/69 (31%), Positives = 24/69 (34%), Gaps = 22/69 (31%)

Query: 191  NSFLPPPPPMPG-PRLGPGKPGLKFNGPPPPP----PPPPPHLLSCWLPPFPSGPPIIPP 245
            N+  PP   M G P      P L  +  P  P    PPPPP                 PP
Sbjct: 3081 NTLTPPGAGMLGFPTSATSSPALSLSSAPTKPLLQTPPPPP-----------------PP 3123

Query: 246  PPPICPDSL 254
            PPP    SL
Sbjct: 3124 PPPPPSSSL 3132


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 67/245 (27%), Positives = 92/245 (37%), Gaps = 63/245 (25%)

Query: 47   VASFKHALKNGD---------ICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQ-----W 92
            +ASF   LK+G          +      PK+ P   PA+  + Q   T A         +
Sbjct: 1282 MASFLDFLKSGKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAF 1341

Query: 93   KVGDKCSAIWSED---GCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVA 149
             +G    A  SE    GC  P      + KR                NL  L S   +  
Sbjct: 1342 GLGGALEAAESEGLGLGCPSPCKRLDEELKR----------------NLETLPSFSSDEE 1385

Query: 150  NNIEQNAQENEN-ESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPG-PRLG- 206
            +++ +N    E+  S +S  +      P + S    P  AP  + +P PPP+PG P    
Sbjct: 1386 DSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAP-AAAVPGPPPLPGLPSANS 1444

Query: 207  ---PGKPGLKFNGPP-----------PPPPPPPPHLLSCWLPPFPSGPPII------PPP 246
               P  P L+   PP           PPPPPPPP       P  PS PP++      PPP
Sbjct: 1445 NGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQ------PALPSPPPLVAPTPSSPPP 1498

Query: 247  PPICP 251
            PP+ P
Sbjct: 1499 PPLPP 1503



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 41/142 (28%), Positives = 55/142 (38%), Gaps = 37/142 (26%)

Query: 147  EVANNIEQ--NAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPM---- 200
            E+  N+E   +   +E +S     + + S S    + +  P + P ++  P  PP+    
Sbjct: 1369 ELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAA 1428

Query: 201  --PGPRLGPGKPGLKFNG------------------------PPPPPPPPPPHL-----L 229
              PGP   PG P    NG                        PPPPPPPP P L     L
Sbjct: 1429 AVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPL 1488

Query: 230  SCWLPPFPSGPPIIPPPPPICP 251
                P  P  PP+ PPPPP  P
Sbjct: 1489 VAPTPSSPPPPPLPPPPPPAMP 1510



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 30/60 (50%), Positives = 31/60 (51%), Gaps = 12/60 (20%)

Query: 195  PPPPPMPGPRLGPGKPGLKF---NGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICP 251
            PPPPP P P L P  P L     + PPPPP PPPP       P  PS PP  PPPP   P
Sbjct: 1472 PPPPPPPQPAL-PSPPPLVAPTPSSPPPPPLPPPPP------PAMPSPPP--PPPPAAAP 1522



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 26/72 (36%), Positives = 28/72 (38%), Gaps = 8/72 (11%)

Query: 185  PKSAPWNSFLPPPPPMPGPR-LGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPII 243
            P   P    LP PPP+  P    P  P L    PP  P PPPP       PP  + P   
Sbjct: 1473 PPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPP-------PPPAAAPLAA 1525

Query: 244  PPPPPICPDSLD 255
            PP  P  P   D
Sbjct: 1526 PPEEPAAPSPED 1537



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 32/97 (32%), Positives = 37/97 (38%), Gaps = 32/97 (32%)

Query: 194 LPPPPPM---------PGPRLGPGKPGLKF---------NGPPPPPPPPPP--------H 227
           LPPPPP          P P     K G+             PPPPPPPPPP        H
Sbjct: 794 LPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAH 853

Query: 228 LLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSML 264
           L S  L P    P + P       +SLD   A+  +L
Sbjct: 854 LRSHGLEPAAPSPRLRP------EESLDPPGAMQELL 884



 Score = 38.1 bits (87), Expect = 0.009
 Identities = 26/71 (36%), Positives = 28/71 (39%), Gaps = 16/71 (22%)

Query: 185  PKSAPWNSFLPPPP--PMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPI 242
            P  AP  S  PPPP  P P P +            P PPPPPPP       PP     P 
Sbjct: 1487 PLVAPTPSSPPPPPLPPPPPPAM------------PSPPPPPPPAAAPLAAPPEEPAAP- 1533

Query: 243  IPPPPPICPDS 253
              P  P  PD+
Sbjct: 1534 -SPEDPELPDT 1543



 Score = 37.4 bits (85), Expect = 0.016
 Identities = 29/80 (36%), Positives = 30/80 (37%), Gaps = 23/80 (28%)

Query: 195 PPPPPMPGPRLGPGKPGL--KFNGPPPPP--PPPPPHLLSCWLPPFPS------------ 238
           PPPPP       P   GL  +  GP  P   PPPPP LL   L   PS            
Sbjct: 764 PPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHL 823

Query: 239 -------GPPIIPPPPPICP 251
                  G P  PPPPP  P
Sbjct: 824 LEPATRDGAPQPPPPPPPPP 843



 Score = 34.3 bits (77), Expect = 0.13
 Identities = 20/46 (43%), Positives = 21/46 (45%), Gaps = 17/46 (36%)

Query: 198  PPMPGPRLGPGKP------------GLKFNGP-----PPPPPPPPP 226
            P  PG  L P KP            GL  +GP     PPPPPPPPP
Sbjct: 1003 PETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPP 1048



 Score = 33.1 bits (74), Expect = 0.30
 Identities = 23/79 (29%), Positives = 32/79 (40%), Gaps = 14/79 (17%)

Query: 178  NKSDNIKPKSA-PWNSFLPPPPPMPGPRLGPGKPGLKFNG--------PPPPPPPPPPHL 228
            NK D ++  +  PW+      PP+P  R G  K  +   G        P PPP P  P  
Sbjct: 1654 NKKDYVRVCARKPWHR-----PPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEK 1708

Query: 229  LSCWLPPFPSGPPIIPPPP 247
             +   PP  +    +P PP
Sbjct: 1709 TTSEKPPEQTPETAMPEPP 1727



 Score = 31.6 bits (70), Expect = 0.87
 Identities = 23/68 (33%), Positives = 24/68 (35%), Gaps = 14/68 (20%)

Query: 195  PPPPPMPGPRLGPGKPGLKFNGPPPPP-----PPPPPHLLSC---------WLPPFPSGP 240
            PPP P      GP  PG      P  P     P  PP L S             P  + P
Sbjct: 980  PPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAP 1039

Query: 241  PIIPPPPP 248
            P  PPPPP
Sbjct: 1040 PPPPPPPP 1047



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 17/40 (42%), Positives = 19/40 (47%), Gaps = 1/40 (2%)

Query: 195 PPPPPMPGPRLGPG-KPGLKFNGPPPPPPPPPPHLLSCWL 233
           PPPP    PR     K   +     PPPPPPP H L  +L
Sbjct: 275 PPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQHYL 314



 Score = 30.0 bits (66), Expect = 2.5
 Identities = 24/78 (30%), Positives = 29/78 (37%), Gaps = 27/78 (34%)

Query: 196 PPPPMPGPRLGPGKPGL-------------------KFNGPPPPPPPPPPHL------LS 230
           PP P P PR  P +  L                    F+G  P PPPP   L      + 
Sbjct: 231 PPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTVIK 290

Query: 231 CWLPPFPSGPPIIPPPPP 248
            +  P  + PP  PPPPP
Sbjct: 291 HYQRPASAQPP--PPPPP 306



 Score = 28.1 bits (61), Expect = 9.6
 Identities = 21/52 (40%), Positives = 23/52 (44%), Gaps = 5/52 (9%)

Query: 182 NIKPKSAPW-NSFLPPPPPMPGPRLGPGKPGLKFNGP----PPPPPPPPPHL 228
           ++KP  AP   S L       G  LGP   G     P    PP PPPPP HL
Sbjct: 190 HLKPSQAPTVPSSLGFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHL 241



 Score = 28.1 bits (61), Expect = 9.6
 Identities = 11/20 (55%), Positives = 14/20 (70%), Gaps = 2/20 (10%)

Query: 214 FNGPPPPPP--PPPPHLLSC 231
           ++G PP PP  PPPP L +C
Sbjct: 475 YSGGPPQPPSGPPPPGLATC 494


>gi|6382071 diaphanous 2 isoform 12C [Homo sapiens]
          Length = 1096

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 42/112 (37%), Positives = 51/112 (45%), Gaps = 25/112 (22%)

Query: 147 EVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLG 206
           E    +E   Q+   ++QV    S +S  PG       P +AP    + PPPP P P L 
Sbjct: 523 EKIKELEAEIQQLRTQAQVL---SSSSGIPG-------PPAAPPLPGVGPPPPPPAPPLP 572

Query: 207 PGKPGLKFNGPPPP-------PPPPPPHLLSCWLPPFPSGPPI--IPPPPPI 249
            G P      PPPP       PPPPPP LL    PP    PP+  +PPPP I
Sbjct: 573 GGAP---LPPPPPPLPGMMGIPPPPPPPLLFGGPPP---PPPLGGVPPPPGI 618


>gi|5803003 diaphanous 2 isoform 156 [Homo sapiens]
          Length = 1101

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 42/112 (37%), Positives = 51/112 (45%), Gaps = 25/112 (22%)

Query: 147 EVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLG 206
           E    +E   Q+   ++QV    S +S  PG       P +AP    + PPPP P P L 
Sbjct: 523 EKIKELEAEIQQLRTQAQVL---SSSSGIPG-------PPAAPPLPGVGPPPPPPAPPLP 572

Query: 207 PGKPGLKFNGPPPP-------PPPPPPHLLSCWLPPFPSGPPI--IPPPPPI 249
            G P      PPPP       PPPPPP LL    PP    PP+  +PPPP I
Sbjct: 573 GGAP---LPPPPPPLPGMMGIPPPPPPPLLFGGPPP---PPPLGGVPPPPGI 618


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.133    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,644,047
Number of Sequences: 37866
Number of extensions: 1521750
Number of successful extensions: 31977
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 883
Number of HSP's successfully gapped in prelim test: 840
Number of HSP's that attempted gapping in prelim test: 9889
Number of HSP's gapped (non-prelim): 10359
length of query: 294
length of database: 18,247,518
effective HSP length: 101
effective length of query: 193
effective length of database: 14,423,052
effective search space: 2783649036
effective search space used: 2783649036
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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