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Search of human proteins with 4506735
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
(772 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 1545 0.0
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 1526 0.0
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 1000 0.0
gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b... 746 0.0
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 543 e-154
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 541 e-154
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 540 e-153
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 535 e-152
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 535 e-152
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 520 e-147
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 336 6e-92
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 334 2e-91
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 269 6e-72
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 269 6e-72
gi|4502023 AKT2 kinase [Homo sapiens] 266 5e-71
gi|62241015 AKT1 kinase [Homo sapiens] 262 8e-70
gi|62241013 AKT1 kinase [Homo sapiens] 262 8e-70
gi|62241011 AKT1 kinase [Homo sapiens] 262 8e-70
gi|133908623 protein kinase C, iota [Homo sapiens] 261 2e-69
gi|28557781 protein kinase C, eta [Homo sapiens] 258 2e-68
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 258 2e-68
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 258 2e-68
gi|4506067 protein kinase C, alpha [Homo sapiens] 257 3e-68
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 250 4e-66
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 250 4e-66
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 250 4e-66
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 250 4e-66
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 249 5e-66
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 248 1e-65
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 248 1e-65
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 1545 bits (4001), Expect = 0.0
Identities = 772/772 (100%), Positives = 772/772 (100%)
Query: 1 MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK
Sbjct: 1 MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
Query: 61 LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120
LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG
Sbjct: 61 LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120
Query: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180
GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF
Sbjct: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180
Query: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240
GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL
Sbjct: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240
Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF
Sbjct: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS
Sbjct: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
Query: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG 420
FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG
Sbjct: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG 420
Query: 421 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 480
SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY
Sbjct: 421 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 480
Query: 481 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD 540
LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD
Sbjct: 481 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD 540
Query: 541 DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 600
DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY
Sbjct: 541 DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 600
Query: 601 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 660
MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA
Sbjct: 601 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 660
Query: 661 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 720
KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK
Sbjct: 661 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 720
Query: 721 SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 772
SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
Sbjct: 721 SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 772
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 1526 bits (3950), Expect = 0.0
Identities = 766/772 (99%), Positives = 766/772 (99%), Gaps = 6/772 (0%)
Query: 1 MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK
Sbjct: 1 MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
Query: 61 LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120
LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG
Sbjct: 61 LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120
Query: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180
GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF
Sbjct: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180
Query: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240
GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL
Sbjct: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240
Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF
Sbjct: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS
Sbjct: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
Query: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG 420
FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMM QQYELDLREPALGQG
Sbjct: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMM------QQYELDLREPALGQG 414
Query: 421 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 480
SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY
Sbjct: 415 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 474
Query: 481 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD 540
LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD
Sbjct: 475 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD 534
Query: 541 DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 600
DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY
Sbjct: 535 DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 594
Query: 601 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 660
MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA
Sbjct: 595 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 654
Query: 661 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 720
KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK
Sbjct: 655 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 714
Query: 721 SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 772
SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
Sbjct: 715 SVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 766
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 1000 bits (2586), Expect = 0.0
Identities = 497/773 (64%), Positives = 610/773 (78%), Gaps = 6/773 (0%)
Query: 2 GDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKL 61
G + ++ V+ + ANLTGH EKV +ENFELLKVLGTGAYGKVFLVRK GHD GKL
Sbjct: 18 GGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKL 77
Query: 62 YAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGG 121
YAMKVL+KA +VQ+AKT EHTRTER VLE +RQ+PFLVTLHYAFQT+ KLHLILDY++GG
Sbjct: 78 YAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG 137
Query: 122 EMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFG 181
E+FTHL QR+ F E EV++Y GEIVLALEHLHKLGIIYRD+KLEN+LLDS GH+VLTDFG
Sbjct: 138 ELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFG 197
Query: 182 LSKEFLTEEKERTFSFCGTIEYMAPEIIR-SKTGHGKAVDWWSLGILLFELLTGASPFTL 240
LSKEF+ +E ER +SFCGTIEYMAP+I+R +GH KAVDWWSLG+L++ELLTGASPFT+
Sbjct: 198 LSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV 257
Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
+GE+N+QAE+SRRILK PP+P + +A+DL+QRLL KDPKKRLG GP+ A E++ H F
Sbjct: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317
Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
FQ ++W LAA+K+PAPF+P IR ELDV NFAEEFT ++P YSP P + ++FQGYS
Sbjct: 318 FQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSE-KLFQGYS 376
Query: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG 420
FVAPSILF N AV+ D L+ +RPG VARSAMM+DSPF+Q Y+LDL++ LG+G
Sbjct: 377 FVAPSILFKRNAAVI-DPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEG 435
Query: 421 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 480
SFS+CR+C ++S Q FAVKI+S+R+EANTQ+E+ AL+LC+ HPN+V LHEV HDQLHT+
Sbjct: 436 SFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTF 495
Query: 481 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD 540
LV+ELL GGEL E I+KK+HFSE+EAS I+R LVSAVS MH + GVVHRDLKPEN+L+ D
Sbjct: 496 LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVVHRDLKPENLLFTD 554
Query: 541 DTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILY 600
+ +KIIDFGFARL+P P++TPCFTL YAAPELL Q GYDESCDLWSLGVILY
Sbjct: 555 ENDNLEIKIIDFGFARLKPPD-NQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILY 613
Query: 601 MMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPA 660
MLSGQVPFQ + A EIM KI++G FS +GEAW+ VS+EAK+L++GLLTVDP
Sbjct: 614 TMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPN 673
Query: 661 KRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLK 720
KRLK+ GLR + WLQDGS SS PL TPD+L SSG AV + + ATF AFN+ KREGF L+
Sbjct: 674 KRLKMSGLRYNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQ 733
Query: 721 SVENAPLAKRRKQKLRS-ATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS 772
+V+ APLAKRRK K S +T +R S ++ + K P + P P+
Sbjct: 734 NVDKAPLAKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPA 786
>gi|32528297 ribosomal protein S6 kinase, polypeptide 5 isoform b
[Homo sapiens]
Length = 549
Score = 746 bits (1926), Expect = 0.0
Identities = 361/534 (67%), Positives = 442/534 (82%), Gaps = 4/534 (0%)
Query: 2 GDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKL 61
G + ++ V+ + ANLTGH EKV +ENFELLKVLGTGAYGKVFLVRK GHD GKL
Sbjct: 18 GGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKL 77
Query: 62 YAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGG 121
YAMKVL+KA +VQ+AKT EHTRTER VLE +RQ+PFLVTLHYAFQT+ KLHLILDY++GG
Sbjct: 78 YAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGG 137
Query: 122 EMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFG 181
E+FTHL QR+ F E EV++Y GEIVLALEHLHKLGIIYRD+KLEN+LLDS GH+VLTDFG
Sbjct: 138 ELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFG 197
Query: 182 LSKEFLTEEKERTFSFCGTIEYMAPEIIR-SKTGHGKAVDWWSLGILLFELLTGASPFTL 240
LSKEF+ +E ER +SFCGTIEYMAP+I+R +GH KAVDWWSLG+L++ELLTGASPFT+
Sbjct: 198 LSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTV 257
Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
+GE+N+QAE+SRRILK PP+P + +A+DL+QRLL KDPKKRLG GP+ A E++ H F
Sbjct: 258 DGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLF 317
Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYS 360
FQ ++W LAA+K+PAPF+P IR ELDV NFAEEFT ++P YSP P + ++FQGYS
Sbjct: 318 FQKINWDDLAAKKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSE-KLFQGYS 376
Query: 361 FVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQG 420
FVAPSILF N AV+ D L+ +RPG VARSAMM+DSPF+Q Y+LDL++ LG+G
Sbjct: 377 FVAPSILFKRNAAVI-DPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEG 435
Query: 421 SFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTY 480
SFS+CR+C ++S Q FAVKI+S+R+EANTQ+E+ AL+LC+ HPN+V LHEV HDQLHT+
Sbjct: 436 SFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTF 495
Query: 481 LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPE 534
LV+ELL GGEL E I+KK+HFSE+EAS I+R LVSAVS MH + GVVHRDLKPE
Sbjct: 496 LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMH-DVGVVHRDLKPE 548
Score = 110 bits (275), Expect = 5e-24
Identities = 77/259 (29%), Positives = 137/259 (52%), Gaps = 23/259 (8%)
Query: 417 LGQGSFS---VCRRCRQRQSGQEFAVKILSR-------RLEANTQREVAALRLCQSHPNV 466
LG G++ + R+ +G+ +A+K+L + + +T+ E L + P +
Sbjct: 55 LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFL 114
Query: 467 VNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGV 526
V LH + +L+L+ + GGEL H+ ++ F+E E + +V A+ +H+ G+
Sbjct: 115 VTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHK-LGI 173
Query: 527 VHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELL--AQQ 584
++RD+K ENIL D+ G V + DFG ++ + C T++Y AP+++
Sbjct: 174 IYRDIKLENILL--DSNGHVV-LTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDS 230
Query: 585 GYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVS 644
G+D++ D WSLGV++Y +L+G PF + G ++ AEI +I + + Q +S
Sbjct: 231 GHDKAVDWWSLGVLMYELLTGASPF---TVDGEKNSQAEISRRILKS----EPPYPQEMS 283
Query: 645 EEAKELVRGLLTVDPAKRL 663
AK+L++ LL DP KRL
Sbjct: 284 ALAKDLIQRLLMKDPKKRL 302
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 543 bits (1400), Expect = e-154
Identities = 316/737 (42%), Positives = 440/737 (59%), Gaps = 39/737 (5%)
Query: 5 DDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAM 64
D DE E+ IT G EK +FELLKVLG G++GKVFLVRK D+G LYAM
Sbjct: 44 DSDEGVLKEISITHHVKAG-SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAM 102
Query: 65 KVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMF 124
KVL+KA L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++F
Sbjct: 103 KVLKKATLKVRDRVR--TKMERDILADVNH-PFVVKLHYAFQTEGKLYLILDFLRGGDLF 159
Query: 125 THLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSK 184
T L + F E +V+ Y E+ L L+HLH LGIIYRDLK EN+LLD EGHI LTDFGLSK
Sbjct: 160 TRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK 219
Query: 185 EFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGER 244
E + EK + +SFCGT+EYMAPE++ ++ GH + DWWS G+L+FE+LTG+ PF +
Sbjct: 220 EAIDHEK-KAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF----QG 273
Query: 245 NTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGL 304
+ E ILK P + AQ LL+ L ++P RLG+GP GA+E++ H F+ +
Sbjct: 274 KDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTI 333
Query: 305 DWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAP 364
DW L R+I PF+P + D F EFT P SP P G ++F+G+SFVA
Sbjct: 334 DWNKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVAT 393
Query: 365 SILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSV 424
++ D DG P A P +V + ++ F Y + + +G GS+S
Sbjct: 394 GLMED-------DG--KPRAPQAP-LHSVVQQLHGKNLVFSDGYVV---KETIGVGSYSE 440
Query: 425 CRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 484
C+RC + + E+AVK++ + + + E+ L HPN++ L +V+ D H YLV E
Sbjct: 441 CKRCVHKATNMEYAVKVIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTE 499
Query: 485 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 544
L+RGGELL+ I +++ FSE EAS +L ++ V ++H + GVVHRDLKP NILY D++ G
Sbjct: 500 LMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDLKPSNILYVDES-G 557
Query: 545 AP--VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMM 602
P ++I DFGFA+ G+ + TPC+T + APE+L +QGYDE CD+WSLG++LY M
Sbjct: 558 NPECLRICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTM 616
Query: 603 LSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKR 662
L+G PF G EI+ +I G+F+L G W VSE AK+LV +L VDP +R
Sbjct: 617 LAGYTPF----ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQR 672
Query: 663 LKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSV 722
L + + W+ L D+ V+ + AT+ A N K LK +
Sbjct: 673 LTAKQVLQHPWVTQKDKLPQSQLSHQDL-----QLVKGAMAATYSALNSSKPTP-QLKPI 726
Query: 723 ENAPLAKRRKQKLRSAT 739
E++ LA+RR +KL S T
Sbjct: 727 ESSILAQRRVRKLPSTT 743
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 541 bits (1394), Expect = e-154
Identities = 315/735 (42%), Positives = 439/735 (59%), Gaps = 39/735 (5%)
Query: 7 DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66
DE E+ IT G EK +FELLKVLG G++GKVFLVRK D+G LYAMKV
Sbjct: 37 DEGVLKEISITHHVKAG-SEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKV 95
Query: 67 LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 126
L+KA L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++FT
Sbjct: 96 LKKATLKVRDRVR--TKMERDILADVNH-PFVVKLHYAFQTEGKLYLILDFLRGGDLFTR 152
Query: 127 LYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEF 186
L + F E +V+ Y E+ L L+HLH LGIIYRDLK EN+LLD EGHI LTDFGLSKE
Sbjct: 153 LSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 212
Query: 187 LTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNT 246
+ EK + +SFCGT+EYMAPE++ ++ GH + DWWS G+L+FE+LTG+ PF +
Sbjct: 213 IDHEK-KAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF----QGKD 266
Query: 247 QAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDW 306
+ E ILK P + AQ LL+ L ++P RLG+GP GA+E++ H F+ +DW
Sbjct: 267 RKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDW 326
Query: 307 VALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSI 366
L R+I PF+P + D F EFT P SP P G ++F+G+SFVA +
Sbjct: 327 NKLYRREIKPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGL 386
Query: 367 LFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCR 426
+ D DG P A P +V + ++ F Y + + +G GS+S C+
Sbjct: 387 MED-------DG--KPRAPQAP-LHSVVQQLHGKNLVFSDGYVV---KETIGVGSYSECK 433
Query: 427 RCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELL 486
RC + + E+AVK++ + + + E+ L HPN++ L +V+ D H YLV EL+
Sbjct: 434 RCVHKATNMEYAVKVIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELM 492
Query: 487 RGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAP 546
RGGELL+ I +++ FSE EAS +L ++ V ++H + GVVHRDLKP NILY D++ G P
Sbjct: 493 RGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQ-GVVHRDLKPSNILYVDES-GNP 550
Query: 547 --VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLS 604
++I DFGFA+ G+ + TPC+T + APE+L +QGYDE CD+WSLG++LY ML+
Sbjct: 551 ECLRICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLA 609
Query: 605 GQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLK 664
G PF G EI+ +I G+F+L G W VSE AK+LV +L VDP +RL
Sbjct: 610 GYTPF----ANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLT 665
Query: 665 LEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVEN 724
+ + W+ L D+ V+ + AT+ A N K LK +E+
Sbjct: 666 AKQVLQHPWVTQKDKLPQSQLSHQDL-----QLVKGAMAATYSALNSSKPTP-QLKPIES 719
Query: 725 APLAKRRKQKLRSAT 739
+ LA+RR +KL S T
Sbjct: 720 SILAQRRVRKLPSTT 734
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 540 bits (1392), Expect = e-153
Identities = 318/746 (42%), Positives = 442/746 (59%), Gaps = 45/746 (6%)
Query: 1 MGDED----DDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGH 56
MG+E+ +E E+ IT GHE K FELLKVLG G++GKVFLV+K G
Sbjct: 33 MGEEEINPQTEEVSIKEIAITHHVKEGHE-KADPSQFELLKVLGQGSFGKVFLVKKISGS 91
Query: 57 DAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILD 116
DA +LYAMKVL+KA L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD
Sbjct: 92 DARQLYAMKVLKKATLKVRDRVR--TKMERDILVEVNH-PFIVKLHYAFQTEGKLYLILD 148
Query: 117 YVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIV 176
++ GG++FT L + F E +V+ Y E+ LAL+HLH LGIIYRDLK EN+LLD EGHI
Sbjct: 149 FLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK 208
Query: 177 LTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGAS 236
LTDFGLSKE + EK + +SFCGT+EYMAPE++ ++ GH ++ DWWS G+L+FE+LTG
Sbjct: 209 LTDFGLSKESIDHEK-KAYSFCGTVEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTL 266
Query: 237 PFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVR 296
PF + + E ILK P + P AQ LL+ L ++P RLGAGP G +E++
Sbjct: 267 PF----QGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIK 322
Query: 297 NHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIF 356
H FF +DW L R+I PF+P D F EFT P SP P ++F
Sbjct: 323 RHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLF 382
Query: 357 QGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPA 416
+G+SFVA + D + A+ T G+ ++ + F YE+ +
Sbjct: 383 RGFSFVAIT-SDDESQAMQTVGVH-----------SIVQQLHRNSIQFTDGYEV---KED 427
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQ 476
+G GS+SVC+RC + + EFAVKI+ + T+ LR Q HPN++ L +V+ D
Sbjct: 428 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQ-HPNIITLKDVYDDG 486
Query: 477 LHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENI 536
+ Y+V EL++GGELL+ I +++ FSE EAS +L ++ V ++H + GVVHRDLKP NI
Sbjct: 487 KYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQ-GVVHRDLKPSNI 545
Query: 537 LYADDTPGAP--VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWS 594
LY D++ G P ++I DFGFA+ G+ + TPC+T + APE+L +QGYD +CD+WS
Sbjct: 546 LYVDES-GNPESIRICDFGFAKQLRAENGL-LMTPCYTANFVAPEVLKRQGYDAACDIWS 603
Query: 595 LGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGL 654
LGV+LY ML+G PF G EI+ +I G+FSL G W VS+ AK+LV +
Sbjct: 604 LGVLLYTMLTGYTPF----ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKM 659
Query: 655 LTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKR 714
L VDP +RL + W+ L D + V+ + AT+ A NR +
Sbjct: 660 LHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQD----APHLVKGAMAATYSALNRNQS 715
Query: 715 EGFFLKSVENAPLAKRRKQKLRSATA 740
L+ V + LA+RR K ++TA
Sbjct: 716 P--VLEPVGRSTLAQRRGIKKITSTA 739
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 535 bits (1379), Expect = e-152
Identities = 306/737 (41%), Positives = 444/737 (60%), Gaps = 39/737 (5%)
Query: 5 DDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAM 64
+++E E+ I+ G E K FELLKVLG G+YGKVFLVRK G DAG+LYAM
Sbjct: 40 EEEEGVVKEIDISHHVKEGFE-KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAM 98
Query: 65 KVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMF 124
KVL+KA L R + + ++ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++F
Sbjct: 99 KVLKKATLKVRDRVR--SKMERDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLF 155
Query: 125 THLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSK 184
T L + F E +V+ Y E+ LAL+HLH LGIIYRDLK EN+LLD EGHI +TDFGLSK
Sbjct: 156 TRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSK 215
Query: 185 EFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGER 244
E + +K R +SFCGTIEYMAPE++ ++ GH ++ DWWS G+L+FE+LTG+ PF + +
Sbjct: 216 EAIDHDK-RAYSFCGTIEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRK 273
Query: 245 NTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGL 304
T A ILK P + AQ LL+ L ++P RLGAG G +E++ HPFF +
Sbjct: 274 ETMA----LILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTI 329
Query: 305 DWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAP 364
DW L ++I PF+P + D +F EFT P SP P +F+G+SFVA
Sbjct: 330 DWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVAS 389
Query: 365 SILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSV 424
S++ + + + P + + + F YE+ + +G GS+SV
Sbjct: 390 SLIQEPSQQDLHKVPVHP----------IVQQLHGNNIHFTDGYEI---KEDIGVGSYSV 436
Query: 425 CRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLE 484
C+RC + + E+AVKI+ + + + E+ L HPN++ L +V+ D YLV+E
Sbjct: 437 CKRCVHKATDTEYAVKIIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVME 495
Query: 485 LLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPG 544
L+RGGELL+ I ++R+FSE EAS +L ++ + ++H + GVVHRDLKP NILY D++ G
Sbjct: 496 LMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-GVVHRDLKPSNILYRDES-G 553
Query: 545 AP--VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMM 602
+P +++ DFGFA+ G+ + TPC+T + APE+L +QGYD +CD+WSLG++LY M
Sbjct: 554 SPESIRVCDFGFAKQLRAGNGL-LMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTM 612
Query: 603 LSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKR 662
L+G PF G EI+ +I G+++L G W +S+ AK++V +L VDP +R
Sbjct: 613 LAGFTPF----ANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR 668
Query: 663 LKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSV 722
L + W+ + S L DV V+ + AT+ A NR + L+ V
Sbjct: 669 LTAMQVLKHPWVVNREYLSPNQLSRQDV-----HLVKGAMAATYFALNR-TPQAPRLEPV 722
Query: 723 ENAPLAKRRKQKLRSAT 739
++ LA+RR K ++T
Sbjct: 723 LSSNLAQRRGMKRLTST 739
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 535 bits (1377), Expect = e-152
Identities = 306/736 (41%), Positives = 443/736 (60%), Gaps = 39/736 (5%)
Query: 6 DDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMK 65
++E E+ I+ G E K FELLKVLG G+YGKVFLVRK G DAG+LYAMK
Sbjct: 33 EEEGVVKEIDISHHVKEGFE-KADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMK 91
Query: 66 VLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFT 125
VL+KA L R + + ++ ER +L V PF+V LHYAFQT+ KL+LILD++ GG++FT
Sbjct: 92 VLKKATLKVRDRVR--SKMERDILAEVNH-PFIVKLHYAFQTEGKLYLILDFLRGGDLFT 148
Query: 126 HLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKE 185
L + F E +V+ Y E+ LAL+HLH LGIIYRDLK EN+LLD EGHI +TDFGLSKE
Sbjct: 149 RLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKE 208
Query: 186 FLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERN 245
+ +K R +SFCGTIEYMAPE++ ++ GH ++ DWWS G+L+FE+LTG+ PF + +
Sbjct: 209 AIDHDK-RAYSFCGTIEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKE 266
Query: 246 TQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
T A ILK P + AQ LL+ L ++P RLGAG G +E++ HPFF +D
Sbjct: 267 TMA----LILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTID 322
Query: 306 WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPS 365
W L ++I PF+P + D +F EFT P SP P +F+G+SFVA S
Sbjct: 323 WNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASS 382
Query: 366 ILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVC 425
++ + + + P + + + F YE+ + +G GS+SVC
Sbjct: 383 LIQEPSQQDLHKVPVHP----------IVQQLHGNNIHFTDGYEI---KEDIGVGSYSVC 429
Query: 426 RRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLEL 485
+RC + + E+AVKI+ + + + E+ L HPN++ L +V+ D YLV+EL
Sbjct: 430 KRCVHKATDTEYAVKIIDKS-KRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMEL 488
Query: 486 LRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGA 545
+RGGELL+ I ++R+FSE EAS +L ++ + ++H + GVVHRDLKP NILY D++ G+
Sbjct: 489 MRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQ-GVVHRDLKPSNILYRDES-GS 546
Query: 546 P--VKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMML 603
P +++ DFGFA+ G+ + TPC+T + APE+L +QGYD +CD+WSLG++LY ML
Sbjct: 547 PESIRVCDFGFAKQLRAGNGL-LMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTML 605
Query: 604 SGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 663
+G PF G EI+ +I G+++L G W +S+ AK++V +L VDP +RL
Sbjct: 606 AGFTPF----ANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL 661
Query: 664 KLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVE 723
+ W+ + S L DV V+ + AT+ A NR + L+ V
Sbjct: 662 TAMQVLKHPWVVNREYLSPNQLSRQDV-----HLVKGAMAATYFALNR-TPQAPRLEPVL 715
Query: 724 NAPLAKRRKQKLRSAT 739
++ LA+RR K ++T
Sbjct: 716 SSNLAQRRGMKRLTST 731
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 520 bits (1340), Expect = e-147
Identities = 310/742 (41%), Positives = 436/742 (58%), Gaps = 42/742 (5%)
Query: 3 DEDDDESCAVELRITEANLTGHE----EKVSVENFELLKVLGTGAYGKVFLVRKAGGHDA 58
+E + +SC E + E +T H EK FELLKVLG G++GKVFLVRK G DA
Sbjct: 39 EEGEADSCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDA 98
Query: 59 GKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYV 118
G+LYAMKVL+KA+L R + + T+ ER +L V PF+V LHYAFQT+ KL+LILD++
Sbjct: 99 GQLYAMKVLKKASLKVRDRVR--TKMERDILVEVNH-PFIVKLHYAFQTEGKLYLILDFL 155
Query: 119 SGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLT 178
GG++FT L + F E +V+ Y E+ LAL+HLH+LGI+YRDLK EN+LLD GHI LT
Sbjct: 156 RGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLT 215
Query: 179 DFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPF 238
DFGLSKE + +EK + +SFCGT+EYMAPE++ ++ GH ++ DWWS G+L+FE+LTG PF
Sbjct: 216 DFGLSKESVDQEK-KAYSFCGTVEYMAPEVV-NRRGHSQSADWWSYGVLMFEMLTGTLPF 273
Query: 239 TLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNH 298
+ + E ILK P + AQ LL+ L ++P RLG+ +G +E++ H
Sbjct: 274 ----QGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEIKRH 327
Query: 299 PFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQG 358
FF +DW L R++ PF+P D F EFT P SP ++F+G
Sbjct: 328 LFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKG 387
Query: 359 YSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALG 418
+SFVA SI ++ +T P G AA F + YEL + +G
Sbjct: 388 FSFVATSIAEEYKITPITSANVLP-IVQINGNAA----------QFGEVYEL---KEDIG 433
Query: 419 QGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLH 478
GS+SVC+RC + EFAVKI+ + + + E+ L HPN++ L +V D +
Sbjct: 434 VGSYSVCKRCIHATTNMEFAVKIIDKS-KRDPSEEIEILMRYGQHPNIITLKDVFDDGRY 492
Query: 479 TYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILY 538
YLV +L++GGELL+ I K++ FSE EAS IL + V ++H + GVVHRDLKP NILY
Sbjct: 493 VYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQ-GVVHRDLKPSNILY 551
Query: 539 ADDTPGA-PVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGV 597
D++ A ++I DFGFA+ G+ + TPC+T + APE+L QQGYD +CD+WSLGV
Sbjct: 552 MDESASADSIRICDFGFAKQLRGENGL-LLTPCYTANFVAPEVLMQQGYDAACDIWSLGV 610
Query: 598 ILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTV 657
+ Y ML+G PF G EI+ +I G+FSL G W +S+ AK+L+ +L +
Sbjct: 611 LFYTMLAGYTPF----ANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHM 666
Query: 658 DPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGF 717
DP +R E + SW+ + + DV V+ + AT+ A K
Sbjct: 667 DPHQRYTAEQILKHSWITHRDQLPNDQPKRNDV----SHVVKGAMVATYSALTH-KTFQP 721
Query: 718 FLKSVENAPLAKRRKQKLRSAT 739
L+ V + LA+RR K R++T
Sbjct: 722 VLEPVAASSLAQRRSMKKRTST 743
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 336 bits (861), Expect = 6e-92
Identities = 179/356 (50%), Positives = 242/356 (67%), Gaps = 8/356 (2%)
Query: 13 ELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAAL 72
+ I+E ++ EK+ E FELL+VLG G YGKVF VRK G + GK++AMKVL+KA +
Sbjct: 71 KFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMI 130
Query: 73 VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132
V+ AK HT+ ER++LE V+ PF+V L YAFQT KL+LIL+Y+SGGE+F L +
Sbjct: 131 VRNAKDTAHTKAERNILEEVKH-PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGI 189
Query: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192
F E Y EI +AL HLH+ GIIYRDLK EN++L+ +GH+ LTDFGL KE + +
Sbjct: 190 FMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGT 248
Query: 193 RTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSR 252
T +FCGTIEYMAPEI+ ++GH +AVDWWSLG L++++LTGA PFT E + T
Sbjct: 249 VTHTFCGTIEYMAPEIL-MRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKT----ID 303
Query: 253 RILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAAR 312
+ILKC PP + A+DLL++LL ++ RLGAGP A EV+ HPFF+ ++W L AR
Sbjct: 304 KILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLAR 363
Query: 313 KIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP-PPGDPRIFQGYSFVAPSIL 367
K+ PF+P ++SE DV F +FTR PV SP S ++F G+++VAPS+L
Sbjct: 364 KVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVL 419
Score = 110 bits (274), Expect = 6e-24
Identities = 74/252 (29%), Positives = 128/252 (50%), Gaps = 22/252 (8%)
Query: 418 GQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQS------HPNVVNLHE 471
G G R+ +G+ FA+K+L + + ++ A + ++ HP +V+L
Sbjct: 101 GYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY 160
Query: 472 VHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDL 531
YL+LE L GGEL + ++ F E A L + A+ +H++ G+++RDL
Sbjct: 161 AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQK-GIIYRDL 219
Query: 532 KPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCD 591
KPENI+ VK+ DFG + G T C T++Y APE+L + G++ + D
Sbjct: 220 KPENIMLNHQ---GHVKLTDFGLCK-ESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVD 275
Query: 592 LWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELV 651
WSLG ++Y ML+G PF G + + ++ + CK+ + +++EA++L+
Sbjct: 276 WWSLGALMYDMLTGAPPFTGENRK--KTIDKILKCKLNLPPY---------LTQEARDLL 324
Query: 652 RGLLTVDPAKRL 663
+ LL + A RL
Sbjct: 325 KKLLKRNAASRL 336
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 334 bits (857), Expect = 2e-91
Identities = 178/356 (50%), Positives = 239/356 (67%), Gaps = 8/356 (2%)
Query: 13 ELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAAL 72
E+ +TE ++ E++ FELL+VLG G YGKVF VRK G + GK+YAMKVLRKA +
Sbjct: 47 EVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKI 106
Query: 73 VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY 132
V+ AK HTR ER++LE V+ PF+V L YAFQT KL+LIL+ +SGGE+FTHL +
Sbjct: 107 VRNAKDTAHTRAERNILESVKH-PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGI 165
Query: 133 FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE 192
F E Y EI LAL HLH GIIYRDLK EN++L S+GHI LTDFGL KE + E
Sbjct: 166 FLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGA 224
Query: 193 RTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSR 252
T +FCGTIEYMAPEI+ ++GH +AVDWWSLG L++++LTG+ PFT E + T ++ R
Sbjct: 225 VTHTFCGTIEYMAPEIL-VRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIR 283
Query: 253 RILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAAR 312
L PP + P A+DL+++ L ++P +R+G GP A +V+ HPFF+ ++W L A
Sbjct: 284 GKL----ALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAW 339
Query: 313 KIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP-PPGDPRIFQGYSFVAPSIL 367
++ PFRP ++SE DV F FTR PV SP + + F G+++VAPS+L
Sbjct: 340 RVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVL 395
Score = 113 bits (283), Expect = 6e-25
Identities = 76/256 (29%), Positives = 131/256 (51%), Gaps = 25/256 (9%)
Query: 417 LGQGSFSVCRRCRQRQS---GQEFAVKILSRRLEANTQREVAALRLCQS------HPNVV 467
LG+G + + R+ Q G+ +A+K+L + ++ A R ++ HP +V
Sbjct: 73 LGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIV 132
Query: 468 NLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVV 527
L YL+LE L GGEL H+ ++ F E A L + A+ +H + G++
Sbjct: 133 ELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQ-GII 191
Query: 528 HRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYD 587
+RDLKPENI+ + +K+ DFG + G T C T++Y APE+L + G++
Sbjct: 192 YRDLKPENIMLSSQ---GHIKLTDFGLCK-ESIHEGAVTHTFCGTIEYMAPEILVRSGHN 247
Query: 588 ESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEA 647
+ D WSLG ++Y ML+G PF + + + M KI G+ +L ++ +A
Sbjct: 248 RAVDWWSLGALMYDMLTGSPPFTAENRK-------KTMDKIIRGKLALP----PYLTPDA 296
Query: 648 KELVRGLLTVDPAKRL 663
++LV+ L +P++R+
Sbjct: 297 RDLVKKFLKRNPSQRI 312
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 269 bits (688), Expect = 6e-72
Identities = 141/324 (43%), Positives = 203/324 (62%), Gaps = 11/324 (3%)
Query: 22 TGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEH 81
T H ++ ++ +F+ LK+LG G +GKV LVR+ +GK YAMK+L+K ++ + + H
Sbjct: 137 TTHHKRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVIIAKDEVA-H 192
Query: 82 TRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVY 141
T TE VL+ R PFL +L Y+FQT +L +++YV+GGE+F HL + + F E R Y
Sbjct: 193 TLTESRVLKNTRH-PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFY 251
Query: 142 GGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTI 201
G EIV AL++LH I+YRDLKLEN++LD +GHI +TDFGL KE +T+ +FCGT
Sbjct: 252 GAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMK-TFCGTP 310
Query: 202 EYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPF 261
EY+APE++ +G+AVDWW LG++++E++ G PF ++ IL F
Sbjct: 311 EYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPF----YNQDHEKLFELILMEDIKF 365
Query: 262 PPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQ 321
P + A+ LL LL KDP KRLG GP A+E+ H FF G++W + +K+ PF+PQ
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
Query: 322 IRSELDVGNFAEEFTRLEPVYSPP 345
+ SE D F EEFT +PP
Sbjct: 426 VTSETDTRYFDEEFTAQTITITPP 449
Score = 114 bits (284), Expect = 4e-25
Identities = 81/253 (32%), Positives = 128/253 (50%), Gaps = 23/253 (9%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 470
LG+G+F R++ SG+ +A+KIL + + A+T E L+ + HP + +L
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSLK 212
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
+ V+E + GGEL H+ ++R FSE +VSA+ ++H +V+RD
Sbjct: 213 YSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRD 271
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LK EN++ D +KI DFG + + M+T C T +Y APE+L Y +
Sbjct: 272 LKLENLMLDKD---GHIKITDFGLCK-EGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV 327
Query: 591 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 650
D W LGV++Y M+ G++PF + K+ E D + + +S +AK L
Sbjct: 328 DWWGLGVVMYEMMCGRLPFYNQDHE-----------KLFELILMEDIKFPRTLSSDAKSL 376
Query: 651 VRGLLTVDPAKRL 663
+ GLL DP KRL
Sbjct: 377 LSGLLIKDPNKRL 389
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 269 bits (688), Expect = 6e-72
Identities = 141/324 (43%), Positives = 203/324 (62%), Gaps = 11/324 (3%)
Query: 22 TGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEH 81
T H ++ ++ +F+ LK+LG G +GKV LVR+ +GK YAMK+L+K ++ + + H
Sbjct: 137 TTHHKRKTMNDFDYLKLLGKGTFGKVILVREKA---SGKYYAMKILKKEVIIAKDEVA-H 192
Query: 82 TRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVY 141
T TE VL+ R PFL +L Y+FQT +L +++YV+GGE+F HL + + F E R Y
Sbjct: 193 TLTESRVLKNTRH-PFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFY 251
Query: 142 GGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTI 201
G EIV AL++LH I+YRDLKLEN++LD +GHI +TDFGL KE +T+ +FCGT
Sbjct: 252 GAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMK-TFCGTP 310
Query: 202 EYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPF 261
EY+APE++ +G+AVDWW LG++++E++ G PF ++ IL F
Sbjct: 311 EYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPF----YNQDHEKLFELILMEDIKF 365
Query: 262 PPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQ 321
P + A+ LL LL KDP KRLG GP A+E+ H FF G++W + +K+ PF+PQ
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQ 425
Query: 322 IRSELDVGNFAEEFTRLEPVYSPP 345
+ SE D F EEFT +PP
Sbjct: 426 VTSETDTRYFDEEFTAQTITITPP 449
Score = 114 bits (284), Expect = 4e-25
Identities = 81/253 (32%), Positives = 128/253 (50%), Gaps = 23/253 (9%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 470
LG+G+F R++ SG+ +A+KIL + + A+T E L+ + HP + +L
Sbjct: 154 LGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSLK 212
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
+ V+E + GGEL H+ ++R FSE +VSA+ ++H +V+RD
Sbjct: 213 YSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRD 271
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LK EN++ D +KI DFG + + M+T C T +Y APE+L Y +
Sbjct: 272 LKLENLMLDKD---GHIKITDFGLCK-EGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV 327
Query: 591 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 650
D W LGV++Y M+ G++PF + K+ E D + + +S +AK L
Sbjct: 328 DWWGLGVVMYEMMCGRLPFYNQDHE-----------KLFELILMEDIKFPRTLSSDAKSL 376
Query: 651 VRGLLTVDPAKRL 663
+ GLL DP KRL
Sbjct: 377 LSGLLIKDPNKRL 389
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 266 bits (680), Expect = 5e-71
Identities = 139/319 (43%), Positives = 199/319 (62%), Gaps = 11/319 (3%)
Query: 27 KVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTER 86
KV++ +F+ LK+LG G +GKV LVR+ G+ YAMK+LRK ++ + + HT TE
Sbjct: 146 KVTMNDFDYLKLLGKGTFGKVILVREKA---TGRYYAMKILRKEVIIAKDEVA-HTVTES 201
Query: 87 SVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIV 146
VL+ R PFL L YAFQT +L +++Y +GGE+F HL + + F E R YG EIV
Sbjct: 202 RVLQNTRH-PFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIV 260
Query: 147 LALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAP 206
ALE+LH ++YRD+KLEN++LD +GHI +TDFGL KE +++ +FCGT EY+AP
Sbjct: 261 SALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMK-TFCGTPEYLAP 319
Query: 207 EIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIG 266
E++ +G+AVDWW LG++++E++ G PF + IL FP +
Sbjct: 320 EVLED-NDYGRAVDWWGLGVVMYEMMCGRLPF----YNQDHERLFELILMEEIRFPRTLS 374
Query: 267 PVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSEL 326
P A+ LL LL KDPK+RLG GP A+EV H FF ++W + +K+ PF+PQ+ SE+
Sbjct: 375 PEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEV 434
Query: 327 DVGNFAEEFTRLEPVYSPP 345
D F +EFT +PP
Sbjct: 435 DTRYFDDEFTAQSITITPP 453
Score = 114 bits (286), Expect = 3e-25
Identities = 82/252 (32%), Positives = 128/252 (50%), Gaps = 21/252 (8%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL---EANTQREVAALRLCQS--HPNVVNLHE 471
LG+G+F R++ +G+ +A+KIL + + + V R+ Q+ HP + L
Sbjct: 158 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 217
Query: 472 VHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDL 531
V+E GGEL H+ ++R F+E A +VSA+ ++H VV+RD+
Sbjct: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSR-DVVYRDI 276
Query: 532 KPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCD 591
K EN++ D +KI DFG + S G M+T C T +Y APE+L Y + D
Sbjct: 277 KLENLMLDKD---GHIKITDFGLCK-EGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVD 332
Query: 592 LWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELV 651
W LGV++Y M+ G++PF + E++ + E RF + +S EAK L+
Sbjct: 333 WWGLGVVMYEMMCGRLPFYNQD----HERLFELIL-MEEIRFP------RTLSPEAKSLL 381
Query: 652 RGLLTVDPAKRL 663
GLL DP +RL
Sbjct: 382 AGLLKKDPKQRL 393
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 262 bits (670), Expect = 8e-70
Identities = 144/340 (42%), Positives = 209/340 (61%), Gaps = 15/340 (4%)
Query: 7 DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66
D S A E+ E +L + +V++ FE LK+LG G +GKV LV++ G+ YAMK+
Sbjct: 127 DNSGAEEM---EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKI 180
Query: 67 LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 126
L+K +V + + HT TE VL+ R PFL L Y+FQT +L +++Y +GGE+F H
Sbjct: 181 LKKEVIVAKDEVA-HTLTENRVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFH 238
Query: 127 LYQRQYFKEAEVRVYGGEIVLALEHLH-KLGIIYRDLKLENVLLDSEGHIVLTDFGLSKE 185
L + + F E R YG EIV AL++LH + ++YRDLKLEN++LD +GHI +TDFGL KE
Sbjct: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298
Query: 186 FLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERN 245
+ + +FCGT EY+APE++ +G+AVDWW LG++++E++ G PF +
Sbjct: 299 GIKDGATMK-TFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE- 355
Query: 246 TQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
++ IL FP +GP A+ LL LL KDPK+RLG G + A+E+ H FF G+
Sbjct: 356 ---KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412
Query: 306 WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPP 345
W + +K+ PF+PQ+ SE D F EEFT +PP
Sbjct: 413 WQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPP 452
Score = 118 bits (295), Expect = 2e-26
Identities = 89/288 (30%), Positives = 139/288 (48%), Gaps = 35/288 (12%)
Query: 395 RSAMMQDSPFFQQYELDLREPA-------------LGQGSFSVCRRCRQRQSGQEFAVKI 441
RS D+ ++ E+ L +P LG+G+F +++ +G+ +A+KI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
Query: 442 LSRRL------EANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHI 495
L + + A+T E L+ + HP + L V+E GGEL H+
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239
Query: 496 RKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFA 555
++R FSE A +VSA+ ++H E VV+RDLK EN++ D +KI DFG
Sbjct: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD---GHIKITDFGLC 296
Query: 556 RLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQ 615
+ G M+T C T +Y APE+L Y + D W LGV++Y M+ G++PF
Sbjct: 297 K-EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD-- 353
Query: 616 GGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 663
+ E++ + E RF + + EAK L+ GLL DP +RL
Sbjct: 354 --HEKLFELIL-MEEIRFP------RTLGPEAKSLLSGLLKKDPKQRL 392
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 262 bits (670), Expect = 8e-70
Identities = 144/340 (42%), Positives = 209/340 (61%), Gaps = 15/340 (4%)
Query: 7 DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66
D S A E+ E +L + +V++ FE LK+LG G +GKV LV++ G+ YAMK+
Sbjct: 127 DNSGAEEM---EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKI 180
Query: 67 LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 126
L+K +V + + HT TE VL+ R PFL L Y+FQT +L +++Y +GGE+F H
Sbjct: 181 LKKEVIVAKDEVA-HTLTENRVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFH 238
Query: 127 LYQRQYFKEAEVRVYGGEIVLALEHLH-KLGIIYRDLKLENVLLDSEGHIVLTDFGLSKE 185
L + + F E R YG EIV AL++LH + ++YRDLKLEN++LD +GHI +TDFGL KE
Sbjct: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298
Query: 186 FLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERN 245
+ + +FCGT EY+APE++ +G+AVDWW LG++++E++ G PF +
Sbjct: 299 GIKDGATMK-TFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE- 355
Query: 246 TQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
++ IL FP +GP A+ LL LL KDPK+RLG G + A+E+ H FF G+
Sbjct: 356 ---KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412
Query: 306 WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPP 345
W + +K+ PF+PQ+ SE D F EEFT +PP
Sbjct: 413 WQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPP 452
Score = 118 bits (295), Expect = 2e-26
Identities = 89/288 (30%), Positives = 139/288 (48%), Gaps = 35/288 (12%)
Query: 395 RSAMMQDSPFFQQYELDLREPA-------------LGQGSFSVCRRCRQRQSGQEFAVKI 441
RS D+ ++ E+ L +P LG+G+F +++ +G+ +A+KI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
Query: 442 LSRRL------EANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHI 495
L + + A+T E L+ + HP + L V+E GGEL H+
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239
Query: 496 RKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFA 555
++R FSE A +VSA+ ++H E VV+RDLK EN++ D +KI DFG
Sbjct: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD---GHIKITDFGLC 296
Query: 556 RLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQ 615
+ G M+T C T +Y APE+L Y + D W LGV++Y M+ G++PF
Sbjct: 297 K-EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD-- 353
Query: 616 GGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 663
+ E++ + E RF + + EAK L+ GLL DP +RL
Sbjct: 354 --HEKLFELIL-MEEIRFP------RTLGPEAKSLLSGLLKKDPKQRL 392
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 262 bits (670), Expect = 8e-70
Identities = 144/340 (42%), Positives = 209/340 (61%), Gaps = 15/340 (4%)
Query: 7 DESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKV 66
D S A E+ E +L + +V++ FE LK+LG G +GKV LV++ G+ YAMK+
Sbjct: 127 DNSGAEEM---EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKI 180
Query: 67 LRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTH 126
L+K +V + + HT TE VL+ R PFL L Y+FQT +L +++Y +GGE+F H
Sbjct: 181 LKKEVIVAKDEVA-HTLTENRVLQNSRH-PFLTALKYSFQTHDRLCFVMEYANGGELFFH 238
Query: 127 LYQRQYFKEAEVRVYGGEIVLALEHLH-KLGIIYRDLKLENVLLDSEGHIVLTDFGLSKE 185
L + + F E R YG EIV AL++LH + ++YRDLKLEN++LD +GHI +TDFGL KE
Sbjct: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298
Query: 186 FLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERN 245
+ + +FCGT EY+APE++ +G+AVDWW LG++++E++ G PF +
Sbjct: 299 GIKDGATMK-TFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNQDHE- 355
Query: 246 TQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
++ IL FP +GP A+ LL LL KDPK+RLG G + A+E+ H FF G+
Sbjct: 356 ---KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIV 412
Query: 306 WVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPP 345
W + +K+ PF+PQ+ SE D F EEFT +PP
Sbjct: 413 WQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPP 452
Score = 118 bits (295), Expect = 2e-26
Identities = 89/288 (30%), Positives = 139/288 (48%), Gaps = 35/288 (12%)
Query: 395 RSAMMQDSPFFQQYELDLREPA-------------LGQGSFSVCRRCRQRQSGQEFAVKI 441
RS D+ ++ E+ L +P LG+G+F +++ +G+ +A+KI
Sbjct: 121 RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180
Query: 442 LSRRL------EANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHI 495
L + + A+T E L+ + HP + L V+E GGEL H+
Sbjct: 181 LKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGELFFHL 239
Query: 496 RKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFA 555
++R FSE A +VSA+ ++H E VV+RDLK EN++ D +KI DFG
Sbjct: 240 SRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKD---GHIKITDFGLC 296
Query: 556 RLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQ 615
+ G M+T C T +Y APE+L Y + D W LGV++Y M+ G++PF
Sbjct: 297 K-EGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQD-- 353
Query: 616 GGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRL 663
+ E++ + E RF + + EAK L+ GLL DP +RL
Sbjct: 354 --HEKLFELIL-MEEIRFP------RTLGPEAKSLLSGLLKKDPKQRL 392
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 261 bits (666), Expect = 2e-69
Identities = 142/349 (40%), Positives = 217/349 (62%), Gaps = 16/349 (4%)
Query: 28 VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87
+ +++F+LL+V+G G+Y KV LVR ++YAMKV++K LV + + +TE+
Sbjct: 249 LGLQDFDLLRVIGRGSYAKVLLVRLK---KTDRIYAMKVVKKE-LVNDDEDIDWVQTEKH 304
Query: 88 VLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVL 147
V E PFLV LH FQT+++L +++YV+GG++ H+ +++ E R Y EI L
Sbjct: 305 VFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISL 364
Query: 148 ALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207
AL +LH+ GIIYRDLKL+NVLLDSEGHI LTD+G+ KE L + T +FCGT Y+APE
Sbjct: 365 ALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGL-RPGDTTSTFCGTPNYIAPE 423
Query: 208 IIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEG-----ERNTQAEVSRRILKCSPPFP 262
I+R + +G +VDWW+LG+L+FE++ G SPF + G ++NT+ + + IL+ P
Sbjct: 424 ILRGE-DYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP 482
Query: 263 PRIGPVAQDLLQRLLCKDPKKRLGAGPQ-GAQEVRNHPFFQGLDWVALAARKIPAPFRPQ 321
+ A +L+ L KDPK+RLG PQ G +++ HPFF+ +DW + +++ PF+P
Sbjct: 483 RSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPN 542
Query: 322 IRSELDVGNFAEEFTRLEPVYSPPGSPP---PGDPRIFQGYSFVAPSIL 367
I E + NF +FT EPV P D F+G+ ++ P ++
Sbjct: 543 ISGEFGLDNFDSQFTN-EPVQLTPDDDDIVRKIDQSEFEGFEYINPLLM 590
Score = 110 bits (276), Expect = 4e-24
Identities = 71/255 (27%), Positives = 133/255 (52%), Gaps = 17/255 (6%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 470
+G+GS++ R +++ + +A+K++ + L + Q E +HP +V LH
Sbjct: 260 IGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLH 319
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
+ + V+E + GG+L+ H++++R E A + A++++HE G+++RD
Sbjct: 320 SCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHER-GIIYRD 378
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LK +N+L D+ G +K+ D+G + PG T C T Y APE+L + Y S
Sbjct: 379 LKLDNVLL--DSEGH-IKLTDYGMCK-EGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSV 434
Query: 591 DLWSLGVILYMMLSGQVPFQ--GASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAK 648
D W+LGV+++ M++G+ PF G+S Q+ + I E + + + +S +A
Sbjct: 435 DWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIP----RSLSVKAA 490
Query: 649 ELVRGLLTVDPAKRL 663
+++ L DP +RL
Sbjct: 491 SVLKSFLNKDPKERL 505
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 258 bits (658), Expect = 2e-68
Identities = 142/343 (41%), Positives = 209/343 (60%), Gaps = 13/343 (3%)
Query: 27 KVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTER 86
++ ++NFE ++VLG G++GKV L R + G LYA+KVL+K ++Q E T TE+
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVK---ETGDLYAVKVLKKDVILQDDDV-ECTMTEK 404
Query: 87 SVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIV 146
+L L R PFL L FQT +L ++++V+GG++ H+ + + F EA R Y EI+
Sbjct: 405 RILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEII 464
Query: 147 LALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAP 206
AL LH GIIYRDLKL+NVLLD EGH L DFG+ KE + T +FCGT +Y+AP
Sbjct: 465 SALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGIC-NGVTTATFCGTPDYIAP 523
Query: 207 EIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIG 266
EI++ +G AVDWW++G+LL+E+L G +PF E E ++ IL +P +
Sbjct: 524 EILQEML-YGPAVDWWAMGVLLYEMLCGHAPFEAENE----DDLFEAILNDEVVYPTWLH 578
Query: 267 PVAQDLLQRLLCKDPKKRLGAGPQGAQE-VRNHPFFQGLDWVALAARKIPAPFRPQIRSE 325
A +L+ + K+P RLG+ QG + + HPFF+ +DW L R+I PFRP+I+S
Sbjct: 579 EDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSR 638
Query: 326 LDVGNFAEEFTRLEPVYSP--PGSPPPGDPRIFQGYSFVAPSI 366
DV NF +F + EPV +P G P + F+ +S+V+P +
Sbjct: 639 EDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPEL 681
Score = 113 bits (283), Expect = 6e-25
Identities = 67/200 (33%), Positives = 106/200 (53%), Gaps = 11/200 (5%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 470
LG+GSF R +++G +AVK+L + + T E L L ++HP + L
Sbjct: 361 LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF 420
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
+ V+E + GG+L+ HI+K R F E+ A ++SA+ F+H++ G+++RD
Sbjct: 421 CCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDK-GIIYRD 479
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LK +N+L + K+ DFG + GV T C T Y APE+L + Y +
Sbjct: 480 LKLDNVLLDHE---GHCKLADFGMCK-EGICNGVTTATFCGTPDYIAPEILQEMLYGPAV 535
Query: 591 DLWSLGVILYMMLSGQVPFQ 610
D W++GV+LY ML G PF+
Sbjct: 536 DWWAMGVLLYEMLCGHAPFE 555
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 258 bits (658), Expect = 2e-68
Identities = 149/343 (43%), Positives = 201/343 (58%), Gaps = 14/343 (4%)
Query: 4 EDDDESCAVELRITEANLT---GHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
ED+DE + +L T N+ +F+ LKV+G G++GKV L ++ GK
Sbjct: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GK 186
Query: 61 LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120
YA+KVL+K ++ R K Q+H ER+VL + PFLV LHY+FQT KL+ +LD+V+G
Sbjct: 187 FYAVKVLQKKIVLNR-KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNG 245
Query: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180
GE+F HL + + F E R Y EI AL +LH + I+YRDLK EN+LLDS GH+VLTDF
Sbjct: 246 GELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDF 305
Query: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240
GL KE + + T +FCGT EY+APE+IR K + VDWW LG +L+E+L G PF
Sbjct: 306 GLCKEGIA-ISDTTTTFCGTPEYLAPEVIR-KQPYDNTVDWWCLGAVLYEMLYGLPPFYC 363
Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
AE+ IL P + A +L+ LL KD + RLGA + E++NHPF
Sbjct: 364 ----RDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPF 418
Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYS 343
F+ L W L +KIP PF P + D+ NF FT YS
Sbjct: 419 FESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYS 461
Score = 108 bits (271), Expect = 1e-23
Identities = 71/203 (34%), Positives = 108/203 (53%), Gaps = 19/203 (9%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANT--QREVAALRLCQ----SHPNVVNLH 470
+G+GSF +++ G+ +AVK+L +++ N Q+ + A R HP +V LH
Sbjct: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLH 227
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
Y VL+ + GGEL H++++R F E A + SA+ ++H +V+RD
Sbjct: 228 YSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHS-IKIVYRD 286
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQ----TPCFTLQYAAPELLAQQGY 586
LKPENIL D+ G V + DFG + G+ + T C T +Y APE++ +Q Y
Sbjct: 287 LKPENILL--DSVGHVV-LTDFGLCK-----EGIAISDTTTTFCGTPEYLAPEVIRKQPY 338
Query: 587 DESCDLWSLGVILYMMLSGQVPF 609
D + D W LG +LY ML G PF
Sbjct: 339 DNTVDWWCLGAVLYEMLYGLPPF 361
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 258 bits (658), Expect = 2e-68
Identities = 149/343 (43%), Positives = 201/343 (58%), Gaps = 14/343 (4%)
Query: 4 EDDDESCAVELRITEANLT---GHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
ED+DE + +L T N+ +F+ LKV+G G++GKV L ++ GK
Sbjct: 130 EDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLD---GK 186
Query: 61 LYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSG 120
YA+KVL+K ++ R K Q+H ER+VL + PFLV LHY+FQT KL+ +LD+V+G
Sbjct: 187 FYAVKVLQKKIVLNR-KEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNG 245
Query: 121 GEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDF 180
GE+F HL + + F E R Y EI AL +LH + I+YRDLK EN+LLDS GH+VLTDF
Sbjct: 246 GELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDF 305
Query: 181 GLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTL 240
GL KE + + T +FCGT EY+APE+IR K + VDWW LG +L+E+L G PF
Sbjct: 306 GLCKEGIA-ISDTTTTFCGTPEYLAPEVIR-KQPYDNTVDWWCLGAVLYEMLYGLPPFYC 363
Query: 241 EGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
AE+ IL P + A +L+ LL KD + RLGA + E++NHPF
Sbjct: 364 ----RDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGA-KEDFLEIQNHPF 418
Query: 301 FQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYS 343
F+ L W L +KIP PF P + D+ NF FT YS
Sbjct: 419 FESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYS 461
Score = 108 bits (271), Expect = 1e-23
Identities = 71/203 (34%), Positives = 108/203 (53%), Gaps = 19/203 (9%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANT--QREVAALRLCQ----SHPNVVNLH 470
+G+GSF +++ G+ +AVK+L +++ N Q+ + A R HP +V LH
Sbjct: 168 IGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLH 227
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
Y VL+ + GGEL H++++R F E A + SA+ ++H +V+RD
Sbjct: 228 YSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHS-IKIVYRD 286
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQ----TPCFTLQYAAPELLAQQGY 586
LKPENIL D+ G V + DFG + G+ + T C T +Y APE++ +Q Y
Sbjct: 287 LKPENILL--DSVGHVV-LTDFGLCK-----EGIAISDTTTTFCGTPEYLAPEVIRKQPY 338
Query: 587 DESCDLWSLGVILYMMLSGQVPF 609
D + D W LG +LY ML G PF
Sbjct: 339 DNTVDWWCLGAVLYEMLYGLPPF 361
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 257 bits (657), Expect = 3e-68
Identities = 142/344 (41%), Positives = 212/344 (61%), Gaps = 13/344 (3%)
Query: 26 EKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTE 85
++V + +F L VLG G++GKV L + G + LYA+K+L+K ++Q E T E
Sbjct: 332 DRVKLTDFNFLMVLGKGSFGKVMLADRKGTEE---LYAIKILKKDVVIQDDDV-ECTMVE 387
Query: 86 RSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEI 145
+ VL L+ + PFL LH FQT +L+ +++YV+GG++ H+ Q FKE + Y EI
Sbjct: 388 KRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEI 447
Query: 146 VLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMA 205
+ L LHK GIIYRDLKL+NV+LDSEGHI + DFG+ KE + + T +FCGT +Y+A
Sbjct: 448 SIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMM-DGVTTRTFCGTPDYIA 506
Query: 206 PEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRI 265
PEII + +GK+VDWW+ G+LL+E+L G PF E E E+ + I++ + +P +
Sbjct: 507 PEIIAYQP-YGKSVDWWAYGVLLYEMLAGQPPFDGEDE----DELFQSIMEHNVSYPKSL 561
Query: 266 GPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSE 325
A + + L+ K P KRLG GP+G ++VR H FF+ +DW L R+I PF+P++ +
Sbjct: 562 SKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK 621
Query: 326 LDVGNFAEEFTRLEPVYSPPGSPPPG--DPRIFQGYSFVAPSIL 367
NF + FTR +PV +PP D F+G+S+V P +
Sbjct: 622 -GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFV 664
Score = 120 bits (300), Expect = 6e-27
Identities = 83/253 (32%), Positives = 127/253 (50%), Gaps = 22/253 (8%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 470
LG+GSF ++ + + +A+KIL + + T E L L P + LH
Sbjct: 345 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 404
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
Y V+E + GG+L+ HI++ F E +A + + F+H+ G+++RD
Sbjct: 405 SCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKR-GIIYRD 463
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LK +N++ D+ G +KI DFG + GV +T C T Y APE++A Q Y +S
Sbjct: 464 LKLDNVML--DSEGH-IKIADFGMCK-EHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSV 519
Query: 591 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 650
D W+ GV+LY ML+GQ PF G E+ I E S + +S+EA +
Sbjct: 520 DWWAYGVLLYEMLAGQPPFDG-------EDEDELFQSIMEHNVSYP----KSLSKEAVSI 568
Query: 651 VRGLLTVDPAKRL 663
+GL+T PAKRL
Sbjct: 569 CKGLMTKHPAKRL 581
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 250 bits (638), Expect = 4e-66
Identities = 152/347 (43%), Positives = 208/347 (59%), Gaps = 23/347 (6%)
Query: 32 NFELLKVLGTGAYGKVFLVRKAGGHDAGKL-YAMKVLRKAALVQRAKTQEHTRTERSVLE 90
+F LKV+G G++GKV L R H A ++ YA+KVL+K A++++ K ++H +ER+VL
Sbjct: 97 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 151
Query: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
+ PFLV LH++FQT KL+ +LDY++GGE+F HL + + F E R Y EI AL
Sbjct: 152 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 211
Query: 151 HLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR 210
+LH L I+YRDLK EN+LLDS+GHIVLTDFGL KE + E T +FCGT EY+APE++
Sbjct: 212 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 270
Query: 211 SKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQ 270
K + + VDWW LG +L+E+L G PF RNT AE+ IL P I A+
Sbjct: 271 -KQPYDRTVDWWCLGAVLYEMLYGLPPFY---SRNT-AEMYDNILNKPLQLKPNITNSAR 325
Query: 271 DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGN 330
LL+ LL KD KRLGA E+++H FF ++W L +KI PF P + D+ +
Sbjct: 326 HLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 384
Query: 331 FAEEFTRLEPVYSPPGSPPPG---------DPRIFQGYSFVAPSILF 368
F EFT EPV + G P F G+S+ P+ F
Sbjct: 385 FDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 430
Score = 110 bits (276), Expect = 4e-24
Identities = 83/253 (32%), Positives = 119/253 (47%), Gaps = 22/253 (8%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 470
+G+GSF R + +AVK+L ++ E + E L HP +V LH
Sbjct: 104 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 163
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
Y VL+ + GGEL H++++R F E A + SA+ ++H +V+RD
Sbjct: 164 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRD 222
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LKPENIL D+ G V + DFG + + T C T +Y APE+L +Q YD +
Sbjct: 223 LKPENILL--DSQGHIV-LTDFGLCKENIEHNSTT-STFCGTPEYLAPEVLHKQPYDRTV 278
Query: 591 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 650
D W LG +LY ML G PF + AE+ I L ++ A+ L
Sbjct: 279 DWWCLGAVLYEMLYGLPPFYSRN-------TAEMYDNILNKPLQLK----PNITNSARHL 327
Query: 651 VRGLLTVDPAKRL 663
+ GLL D KRL
Sbjct: 328 LEGLLQKDRTKRL 340
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 250 bits (638), Expect = 4e-66
Identities = 152/347 (43%), Positives = 208/347 (59%), Gaps = 23/347 (6%)
Query: 32 NFELLKVLGTGAYGKVFLVRKAGGHDAGKL-YAMKVLRKAALVQRAKTQEHTRTERSVLE 90
+F LKV+G G++GKV L R H A ++ YA+KVL+K A++++ K ++H +ER+VL
Sbjct: 111 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 165
Query: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
+ PFLV LH++FQT KL+ +LDY++GGE+F HL + + F E R Y EI AL
Sbjct: 166 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 225
Query: 151 HLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR 210
+LH L I+YRDLK EN+LLDS+GHIVLTDFGL KE + E T +FCGT EY+APE++
Sbjct: 226 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 284
Query: 211 SKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQ 270
K + + VDWW LG +L+E+L G PF RNT AE+ IL P I A+
Sbjct: 285 -KQPYDRTVDWWCLGAVLYEMLYGLPPFY---SRNT-AEMYDNILNKPLQLKPNITNSAR 339
Query: 271 DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGN 330
LL+ LL KD KRLGA E+++H FF ++W L +KI PF P + D+ +
Sbjct: 340 HLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 398
Query: 331 FAEEFTRLEPVYSPPGSPPPG---------DPRIFQGYSFVAPSILF 368
F EFT EPV + G P F G+S+ P+ F
Sbjct: 399 FDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 444
Score = 110 bits (276), Expect = 4e-24
Identities = 83/253 (32%), Positives = 119/253 (47%), Gaps = 22/253 (8%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 470
+G+GSF R + +AVK+L ++ E + E L HP +V LH
Sbjct: 118 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 177
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
Y VL+ + GGEL H++++R F E A + SA+ ++H +V+RD
Sbjct: 178 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRD 236
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LKPENIL D+ G V + DFG + + T C T +Y APE+L +Q YD +
Sbjct: 237 LKPENILL--DSQGHIV-LTDFGLCKENIEHNSTT-STFCGTPEYLAPEVLHKQPYDRTV 292
Query: 591 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 650
D W LG +LY ML G PF + AE+ I L ++ A+ L
Sbjct: 293 DWWCLGAVLYEMLYGLPPFYSRN-------TAEMYDNILNKPLQLK----PNITNSARHL 341
Query: 651 VRGLLTVDPAKRL 663
+ GLL D KRL
Sbjct: 342 LEGLLQKDRTKRL 354
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 250 bits (638), Expect = 4e-66
Identities = 152/347 (43%), Positives = 208/347 (59%), Gaps = 23/347 (6%)
Query: 32 NFELLKVLGTGAYGKVFLVRKAGGHDAGKL-YAMKVLRKAALVQRAKTQEHTRTERSVLE 90
+F LKV+G G++GKV L R H A ++ YA+KVL+K A++++ K ++H +ER+VL
Sbjct: 125 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 179
Query: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
+ PFLV LH++FQT KL+ +LDY++GGE+F HL + + F E R Y EI AL
Sbjct: 180 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 239
Query: 151 HLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR 210
+LH L I+YRDLK EN+LLDS+GHIVLTDFGL KE + E T +FCGT EY+APE++
Sbjct: 240 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 298
Query: 211 SKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQ 270
K + + VDWW LG +L+E+L G PF RNT AE+ IL P I A+
Sbjct: 299 -KQPYDRTVDWWCLGAVLYEMLYGLPPFY---SRNT-AEMYDNILNKPLQLKPNITNSAR 353
Query: 271 DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGN 330
LL+ LL KD KRLGA E+++H FF ++W L +KI PF P + D+ +
Sbjct: 354 HLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 412
Query: 331 FAEEFTRLEPVYSPPGSPPPG---------DPRIFQGYSFVAPSILF 368
F EFT EPV + G P F G+S+ P+ F
Sbjct: 413 FDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 458
Score = 110 bits (276), Expect = 4e-24
Identities = 83/253 (32%), Positives = 119/253 (47%), Gaps = 22/253 (8%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 470
+G+GSF R + +AVK+L ++ E + E L HP +V LH
Sbjct: 132 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 191
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
Y VL+ + GGEL H++++R F E A + SA+ ++H +V+RD
Sbjct: 192 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRD 250
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LKPENIL D+ G V + DFG + + T C T +Y APE+L +Q YD +
Sbjct: 251 LKPENILL--DSQGHIV-LTDFGLCKENIEHNSTT-STFCGTPEYLAPEVLHKQPYDRTV 306
Query: 591 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 650
D W LG +LY ML G PF + AE+ I L ++ A+ L
Sbjct: 307 DWWCLGAVLYEMLYGLPPFYSRN-------TAEMYDNILNKPLQLK----PNITNSARHL 355
Query: 651 VRGLLTVDPAKRL 663
+ GLL D KRL
Sbjct: 356 LEGLLQKDRTKRL 368
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 250 bits (638), Expect = 4e-66
Identities = 152/347 (43%), Positives = 208/347 (59%), Gaps = 23/347 (6%)
Query: 32 NFELLKVLGTGAYGKVFLVRKAGGHDAGKL-YAMKVLRKAALVQRAKTQEHTRTERSVLE 90
+F LKV+G G++GKV L R H A ++ YA+KVL+K A++++ K ++H +ER+VL
Sbjct: 192 DFHFLKVIGKGSFGKVLLAR----HKAEEVFYAVKVLQKKAILKK-KEEKHIMSERNVLL 246
Query: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
+ PFLV LH++FQT KL+ +LDY++GGE+F HL + + F E R Y EI AL
Sbjct: 247 KNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALG 306
Query: 151 HLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIR 210
+LH L I+YRDLK EN+LLDS+GHIVLTDFGL KE + E T +FCGT EY+APE++
Sbjct: 307 YLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENI-EHNSTTSTFCGTPEYLAPEVLH 365
Query: 211 SKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQ 270
K + + VDWW LG +L+E+L G PF RNT AE+ IL P I A+
Sbjct: 366 -KQPYDRTVDWWCLGAVLYEMLYGLPPFY---SRNT-AEMYDNILNKPLQLKPNITNSAR 420
Query: 271 DLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGN 330
LL+ LL KD KRLGA E+++H FF ++W L +KI PF P + D+ +
Sbjct: 421 HLLEGLLQKDRTKRLGA-KDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRH 479
Query: 331 FAEEFTRLEPVYSPPGSPPPG---------DPRIFQGYSFVAPSILF 368
F EFT EPV + G P F G+S+ P+ F
Sbjct: 480 FDPEFTE-EPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSF 525
Score = 110 bits (276), Expect = 4e-24
Identities = 83/253 (32%), Positives = 119/253 (47%), Gaps = 22/253 (8%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRL------EANTQREVAALRLCQSHPNVVNLH 470
+G+GSF R + +AVK+L ++ E + E L HP +V LH
Sbjct: 199 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 258
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
Y VL+ + GGEL H++++R F E A + SA+ ++H +V+RD
Sbjct: 259 FSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHS-LNIVYRD 317
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LKPENIL D+ G V + DFG + + T C T +Y APE+L +Q YD +
Sbjct: 318 LKPENILL--DSQGHIV-LTDFGLCKENIEHNSTT-STFCGTPEYLAPEVLHKQPYDRTV 373
Query: 591 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 650
D W LG +LY ML G PF + AE+ I L ++ A+ L
Sbjct: 374 DWWCLGAVLYEMLYGLPPFYSRN-------TAEMYDNILNKPLQLK----PNITNSARHL 422
Query: 651 VRGLLTVDPAKRL 663
+ GLL D KRL
Sbjct: 423 LEGLLQKDRTKRL 435
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 249 bits (637), Expect = 5e-66
Identities = 138/357 (38%), Positives = 216/357 (60%), Gaps = 14/357 (3%)
Query: 16 ITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQR 75
+++ + G+ +++ + +F L VLG G++GKV L + G +LYA+K+L+K ++Q
Sbjct: 325 VSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKG---TDELYAVKILKKDVVIQD 381
Query: 76 AKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKE 135
E T E+ VL L + PFL LH FQT +L+ +++YV+GG++ H+ Q FKE
Sbjct: 382 DDV-ECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKE 440
Query: 136 AEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTF 195
Y EI + L L GIIYRDLKL+NV+LDSEGHI + DFG+ KE + + T
Sbjct: 441 PHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW-DGVTTK 499
Query: 196 SFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRIL 255
+FCGT +Y+APEII + +GK+VDWW+ G+LL+E+L G +PF EGE + E+ + I+
Sbjct: 500 TFCGTPDYIAPEIIAYQP-YGKSVDWWAFGVLLYEMLAGQAPF--EGE--DEDELFQSIM 554
Query: 256 KCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIP 315
+ + +P + A + + L+ K P KRLG GP+G ++++ H FF+ +DW L ++I
Sbjct: 555 EHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQ 614
Query: 316 APFRPQIRSELDVGNFAEEFTRLEPVYSPPGSP---PPGDPRIFQGYSFVAPSILFD 369
P++P+ R + D NF +EFTR +PV P D F G+S+ P + +
Sbjct: 615 PPYKPKARDKRDTSNFDKEFTR-QPVELTPTDKLFIMNLDQNEFAGFSYTNPEFVIN 670
Score = 115 bits (287), Expect = 2e-25
Identities = 81/253 (32%), Positives = 125/253 (49%), Gaps = 22/253 (8%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 470
LG+GSF ++ + + +AVKIL + + T E L L P + LH
Sbjct: 348 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 407
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
Y V+E + GG+L+ HI++ F E A + + F+ + G+++RD
Sbjct: 408 SCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSK-GIIYRD 466
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LK +N++ D+ G +KI DFG + GV +T C T Y APE++A Q Y +S
Sbjct: 467 LKLDNVML--DSEGH-IKIADFGMCKENIWD-GVTTKTFCGTPDYIAPEIIAYQPYGKSV 522
Query: 591 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 650
D W+ GV+LY ML+GQ PF+G E+ I E + + +S+EA +
Sbjct: 523 DWWAFGVLLYEMLAGQAPFEG-------EDEDELFQSIMEHNVAYP----KSMSKEAVAI 571
Query: 651 VRGLLTVDPAKRL 663
+GL+T P KRL
Sbjct: 572 CKGLMTKHPGKRL 584
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 248 bits (634), Expect = 1e-65
Identities = 140/347 (40%), Positives = 214/347 (61%), Gaps = 14/347 (4%)
Query: 28 VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87
+ +++F+L++V+G G+Y KV LVR ++YAMKV++K LV + + +TE+
Sbjct: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKND---QIYAMKVVKKE-LVHDDEDIDWVQTEKH 119
Query: 88 VLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVL 147
V E PFLV LH FQT ++L L+++YV+GG++ H+ +++ E R Y EI +
Sbjct: 120 VFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICI 179
Query: 148 ALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207
AL LH+ GIIYRDLKL+NVLLD++GHI LTD+G+ KE L + T +FCGT Y+APE
Sbjct: 180 ALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGL-GPGDTTSTFCGTPNYIAPE 238
Query: 208 IIRSKTGHGKAVDWWSLGILLFELLTGASPF---TLEGERNTQAEVSRRILKCSPPFPPR 264
I+R + +G +VDWW+LG+L+FE++ G SPF T + NT+ + + IL+ P
Sbjct: 239 ILRGEE-YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF 297
Query: 265 IGPVAQDLLQRLLCKDPKKRLGAGPQ-GAQEVRNHPFFQGLDWVALAARKIPAPFRPQIR 323
+ A +L+ L KDPK+RLG PQ G ++++H FF+ +DW L ++ PF+PQI
Sbjct: 298 LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT 357
Query: 324 SELDVGNFAEEFTRLEPVYSPPGSPPP---GDPRIFQGYSFVAPSIL 367
+ + NF +FT EPV P D F+G+ ++ P +L
Sbjct: 358 DDYGLDNFDTQFTS-EPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403
Score = 111 bits (277), Expect = 3e-24
Identities = 71/253 (28%), Positives = 128/253 (50%), Gaps = 15/253 (5%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 470
+G+GS++ R +++ Q +A+K++ + L + Q E S+P +V LH
Sbjct: 75 IGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLH 134
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
+LV+E + GG+L+ H++++R E A + A++F+HE G+++RD
Sbjct: 135 SCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER-GIIYRD 193
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LK +N+L D +K+ D+G + PG T C T Y APE+L + Y S
Sbjct: 194 LKLDNVLLDAD---GHIKLTDYGMCK-EGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSV 249
Query: 591 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 650
D W+LGV+++ M++G+ PF + + + I E + + +S +A +
Sbjct: 250 DWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIP----RFLSVKASHV 305
Query: 651 VRGLLTVDPAKRL 663
++G L DP +RL
Sbjct: 306 LKGFLNKDPKERL 318
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 248 bits (634), Expect = 1e-65
Identities = 140/347 (40%), Positives = 214/347 (61%), Gaps = 14/347 (4%)
Query: 28 VSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERS 87
+ +++F+L++V+G G+Y KV LVR ++YAMKV++K LV + + +TE+
Sbjct: 64 LGLQDFDLIRVIGRGSYAKVLLVRLKKND---QIYAMKVVKKE-LVHDDEDIDWVQTEKH 119
Query: 88 VLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVL 147
V E PFLV LH FQT ++L L+++YV+GG++ H+ +++ E R Y EI +
Sbjct: 120 VFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICI 179
Query: 148 ALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPE 207
AL LH+ GIIYRDLKL+NVLLD++GHI LTD+G+ KE L + T +FCGT Y+APE
Sbjct: 180 ALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGL-GPGDTTSTFCGTPNYIAPE 238
Query: 208 IIRSKTGHGKAVDWWSLGILLFELLTGASPF---TLEGERNTQAEVSRRILKCSPPFPPR 264
I+R + +G +VDWW+LG+L+FE++ G SPF T + NT+ + + IL+ P
Sbjct: 239 ILRGEE-YGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRF 297
Query: 265 IGPVAQDLLQRLLCKDPKKRLGAGPQ-GAQEVRNHPFFQGLDWVALAARKIPAPFRPQIR 323
+ A +L+ L KDPK+RLG PQ G ++++H FF+ +DW L ++ PF+PQI
Sbjct: 298 LSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQIT 357
Query: 324 SELDVGNFAEEFTRLEPVYSPPGSPPP---GDPRIFQGYSFVAPSIL 367
+ + NF +FT EPV P D F+G+ ++ P +L
Sbjct: 358 DDYGLDNFDTQFTS-EPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403
Score = 111 bits (277), Expect = 3e-24
Identities = 71/253 (28%), Positives = 128/253 (50%), Gaps = 15/253 (5%)
Query: 417 LGQGSFSVCRRCRQRQSGQEFAVKILSRRLEAN------TQREVAALRLCQSHPNVVNLH 470
+G+GS++ R +++ Q +A+K++ + L + Q E S+P +V LH
Sbjct: 75 IGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLH 134
Query: 471 EVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRD 530
+LV+E + GG+L+ H++++R E A + A++F+HE G+++RD
Sbjct: 135 SCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHER-GIIYRD 193
Query: 531 LKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESC 590
LK +N+L D +K+ D+G + PG T C T Y APE+L + Y S
Sbjct: 194 LKLDNVLLDAD---GHIKLTDYGMCK-EGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSV 249
Query: 591 DLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKEL 650
D W+LGV+++ M++G+ PF + + + I E + + +S +A +
Sbjct: 250 DWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIP----RFLSVKASHV 305
Query: 651 VRGLLTVDPAKRL 663
++G L DP +RL
Sbjct: 306 LKGFLNKDPKERL 318
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,446,078
Number of Sequences: 37866
Number of extensions: 1637148
Number of successful extensions: 10738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 713
Number of HSP's successfully gapped in prelim test: 127
Number of HSP's that attempted gapping in prelim test: 5799
Number of HSP's gapped (non-prelim): 1997
length of query: 772
length of database: 18,247,518
effective HSP length: 110
effective length of query: 662
effective length of database: 14,082,258
effective search space: 9322454796
effective search space used: 9322454796
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.