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Search of human proteins with 4506537
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
sapiens]
(540 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ... 1093 0.0
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 200 2e-51
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 189 4e-48
gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo... 145 9e-35
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 132 6e-31
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 125 1e-28
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 125 1e-28
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 107 3e-23
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 107 3e-23
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 107 3e-23
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 107 3e-23
gi|33188459 B-Raf [Homo sapiens] 103 5e-22
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 100 6e-21
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 100 6e-21
gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Ho... 100 6e-21
gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3... 99 1e-20
gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2... 99 1e-20
gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1... 99 1e-20
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 98 2e-20
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 98 2e-20
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 98 2e-20
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 98 2e-20
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 97 3e-20
gi|148596974 TXK tyrosine kinase [Homo sapiens] 97 4e-20
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 97 4e-20
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 95 2e-19
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 91 2e-18
gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Hom... 90 5e-18
gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 90 6e-18
gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 90 6e-18
>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
sapiens]
Length = 540
Score = 1093 bits (2827), Expect = 0.0
Identities = 540/540 (100%), Positives = 540/540 (100%)
Query: 1 MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER 60
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
Sbjct: 1 MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER 60
Query: 61 KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL 120
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
Sbjct: 61 KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL 120
Query: 121 RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS 180
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
Sbjct: 121 RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS 180
Query: 181 SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY 240
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
Sbjct: 181 SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY 240
Query: 241 SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI 300
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
Sbjct: 241 SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI 300
Query: 301 TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET 360
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
Sbjct: 301 TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET 360
Query: 361 SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN 420
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
Sbjct: 361 SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN 420
Query: 421 PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK 480
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
Sbjct: 421 PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK 480
Query: 481 PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM 540
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Sbjct: 481 PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM 540
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 200 bits (509), Expect = 2e-51
Identities = 119/271 (43%), Positives = 160/271 (59%), Gaps = 23/271 (8%)
Query: 27 GASGTVSSARHADWRVQVAVK---HLHIHTPLLDSERKDVLREAEILHKARFSYILPILG 83
G G V RH W+ +A+K LH+ D ER ++L EA+ + A+F YILP+ G
Sbjct: 31 GGFGQVYKVRHVHWKTWLAIKCSPSLHVD----DRERMELLEEAKKMEMAKFRYILPVYG 86
Query: 84 ICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLL 143
IC EP +G+V EYM GSL +LL + + W LRFRI+HE A+G+N+LH M PPLL
Sbjct: 87 ICREP--VGLVMEYMETGSLEKLLASEP----LPWDLRFRIIHETAVGMNFLHCMAPPLL 140
Query: 144 HHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQK 203
H DLK NILLD +HVKI+DFGL+K +S S S GTI Y+PPE +K
Sbjct: 141 HLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGL--FGTIAYLPPERIR--EK 196
Query: 204 SRA-SIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINE--ESLPYDIP 260
SR KHD+YS+A++ W VL++K+PF D N L IM V +GHRP + + P
Sbjct: 197 SRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARPRACS 256
Query: 261 HRARMISLIESGWAQNPDERPSFLKCLIELE 291
H +I L++ W +P RP+F + E E
Sbjct: 257 H---LIRLMQRCWQGDPRVRPTFQEITSETE 284
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 189 bits (481), Expect = 4e-48
Identities = 127/367 (34%), Positives = 196/367 (53%), Gaps = 35/367 (9%)
Query: 20 DLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDV---LREAEILHKARFS 76
D R ++ G V ARH WR + A+K P D+ DV + EA + K +F
Sbjct: 24 DWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPP--DAASSDVNYLIEEAAKMKKIKFQ 81
Query: 77 YILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLH 136
+I+ I G+C +P LGIV E+M NGSL ++L + + W LRFRI+HE +L +N+LH
Sbjct: 82 HIVSIYGVCKQP--LGIVMEFMANGSLEKVLSTHS----LCWKLRFRIIHETSLAMNFLH 135
Query: 137 NMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE 196
++ PPLLH DLK NILLD+ HVKI+DFGLSKW S +SA G + Y+PPE
Sbjct: 136 SIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALR-GMLSYIPPE 194
Query: 197 NYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLP 256
+ K+ K+D+YS+A++ WE+L++K+P+ N + I+ V+ G RP + S
Sbjct: 195 MFLESNKAPGP-KYDVYSFAIVIWELLTQKKPYSGF-NMMMIIIRVAAGMRPSLQPVSDQ 252
Query: 257 YDIPHRA-RMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQ 315
+ P A +M+ L++ W Q+P +RP FL IE + +L + L++ + + ++K
Sbjct: 253 W--PSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILL------SLLQSRVAVPESKA- 303
Query: 316 SVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSR 375
L K +LSL P G E + +SG+ R+L + + R
Sbjct: 304 -------LARKVSCKLSLRQP---GEVNEDISQELMDSDSGN-YLKRALQLSDRKNLVPR 352
Query: 376 KAQDCYF 382
+ C +
Sbjct: 353 DEELCIY 359
>gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo
sapiens]
Length = 518
Score = 145 bits (366), Expect = 9e-35
Identities = 99/297 (33%), Positives = 157/297 (52%), Gaps = 28/297 (9%)
Query: 11 PTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEIL 70
P + +L + + +G GTV A+H W VAVK ++ K + RE + +
Sbjct: 14 PLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVN---------SKAISREVKAM 64
Query: 71 HKARFSYILPILGICNEPEF-----LGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125
++L + G+ + + +VT++M NGSL+ LL + P WPL R+L
Sbjct: 65 ASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRP---WPLLCRLL 121
Query: 126 HEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAP 185
E+ LG+ YLH+ P LLH DLK N+LLD E HVK+ADFGLS ++ SQS + P
Sbjct: 122 KEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQ--GGSQSGTGSGEP 179
Query: 186 EGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSV-SQ 244
GGT+ Y+ PE + +AS D+YS+ ++ W VL+ ++ E T P + +V ++
Sbjct: 180 -GGTLGYLAPELF-VNVNRKASTASDVYSFGILMWAVLAGRE-VELPTEPSLVYEAVCNR 236
Query: 245 GHRPVINEESLPY---DIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFE 298
+RP + E LP + P + L++ W+ P +RPSF +CL + + V + E
Sbjct: 237 QNRPSLAE--LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVE 291
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 132 bits (333), Expect = 6e-31
Identities = 84/259 (32%), Positives = 140/259 (54%), Gaps = 22/259 (8%)
Query: 63 VLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRF 122
+L EA+++++ R S ++ +LG+ E +V EYM G+L +L + P ++
Sbjct: 60 LLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTP---LSVKG 116
Query: 123 RILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSK 182
RI+ EI G+ YLH ++H DLK +NIL+DN+FH+KIAD GL+ ++M S +
Sbjct: 117 RIILEIIEGMCYLHGKG--VIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHN 174
Query: 183 SAPE--------GGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTN 234
E GGT+ YM PE+ ++ + K D+YS+AV+ W + + K+P+E+
Sbjct: 175 ELREVDGTAKKNGGTLYYMAPEHLN-DVNAKPTEKSDVYSFAVVLWAIFANKEPYENAIC 233
Query: 235 PLQIMYSVSQGHRPVINE--ESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEP 292
Q++ + G+RP +++ E P +I ISL++ W NP+ RP+F + P
Sbjct: 234 EQQLIMCIKSGNRPDVDDITEYCPREI------ISLMKLCWEANPEARPTFPGIEEKFRP 287
Query: 293 VLRTFEEITFLEAVIQLKK 311
+ E + E V LKK
Sbjct: 288 FYLSQLEESVEEDVKSLKK 306
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 125 bits (314), Expect = 1e-28
Identities = 92/294 (31%), Positives = 151/294 (51%), Gaps = 19/294 (6%)
Query: 8 SALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQ-VAVKHLHIHTPLLDSERKDVLRE 66
+ LP+ + +L+++ + SG+ R + VA+K +T S+ RE
Sbjct: 450 AGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCRE 509
Query: 67 AEILHKARFSYILPILGIC-NEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125
IL + ++ +G C N+P IVT+Y+ GSL LLH + D+ L +
Sbjct: 510 VSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAV- 568
Query: 126 HEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAP 185
++A G+ YLHN+T P++H DL + NILL + H +ADFG S++ + SL + +K
Sbjct: 569 -DVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRF-LQSLDEDNMTK--- 623
Query: 186 EGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQG 245
+ G + +M PE + Q +R +IK D++SYA+ WE+L+ + PF + P ++
Sbjct: 624 QPGNLRWMAPEVFT--QCTRYTIKADVFSYALCLWEILTGEIPFAHL-KPAAAAADMAYH 680
Query: 246 H-RPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFE 298
H RP I Y IP + SL+ GW P+ RP F + +++LE L E
Sbjct: 681 HIRPPIG-----YSIP--KPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIE 727
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 125 bits (314), Expect = 1e-28
Identities = 92/294 (31%), Positives = 151/294 (51%), Gaps = 19/294 (6%)
Query: 8 SALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQ-VAVKHLHIHTPLLDSERKDVLRE 66
+ LP+ + +L+++ + SG+ R + VA+K +T S+ RE
Sbjct: 551 AGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCRE 610
Query: 67 AEILHKARFSYILPILGIC-NEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125
IL + ++ +G C N+P IVT+Y+ GSL LLH + D+ L +
Sbjct: 611 VSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAV- 669
Query: 126 HEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAP 185
++A G+ YLHN+T P++H DL + NILL + H +ADFG S++ + SL + +K
Sbjct: 670 -DVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRF-LQSLDEDNMTK--- 724
Query: 186 EGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQG 245
+ G + +M PE + Q +R +IK D++SYA+ WE+L+ + PF + P ++
Sbjct: 725 QPGNLRWMAPEVFT--QCTRYTIKADVFSYALCLWEILTGEIPFAHL-KPAAAAADMAYH 781
Query: 246 H-RPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFE 298
H RP I Y IP + SL+ GW P+ RP F + +++LE L E
Sbjct: 782 HIRPPIG-----YSIP--KPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIE 828
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 107 bits (267), Expect = 3e-23
Identities = 90/289 (31%), Positives = 143/289 (49%), Gaps = 32/289 (11%)
Query: 13 IPYHKLADLRYLSRGASGTVSSARHADWRVQ-VAVKHLHIHTPLLDSERKDVLREAEILH 71
I Y ++ + RGA G V A+ WR + VA+K + +SERK + E L
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAK---WRAKDVAIKQIES-----ESERKAFIVELRQLS 82
Query: 72 KARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALG 131
+ I+ + G C P L V EY GSL +LH P + + G
Sbjct: 83 RVNHPNIVKLYGACLNPVCL--VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 140
Query: 132 VNYLHNMTPP-LLHHDLKTQNILLDNEFHV-KIADFGLSKWRMMSLSQSRSSKSAPEGGT 189
V YLH+M P L+H DLK N+LL V KI DFG + ++ ++ G+
Sbjct: 141 VAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--------GS 192
Query: 190 IIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNP-LQIMYSVSQGHRP 248
+M PE +E S S K D++S+ +I WEV++R++PF+++ P +IM++V G RP
Sbjct: 193 AAWMAPEVFEG---SNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRP 249
Query: 249 VINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTF 297
+ ++LP I SL+ W+++P +RPS + + + ++R F
Sbjct: 250 PL-IKNLPKPIE------SLMTRCWSKDPSQRPSMEEIVKIMTHLMRYF 291
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 107 bits (267), Expect = 3e-23
Identities = 90/289 (31%), Positives = 143/289 (49%), Gaps = 32/289 (11%)
Query: 13 IPYHKLADLRYLSRGASGTVSSARHADWRVQ-VAVKHLHIHTPLLDSERKDVLREAEILH 71
I Y ++ + RGA G V A+ WR + VA+K + +SERK + E L
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAK---WRAKDVAIKQIES-----ESERKAFIVELRQLS 82
Query: 72 KARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALG 131
+ I+ + G C P L V EY GSL +LH P + + G
Sbjct: 83 RVNHPNIVKLYGACLNPVCL--VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 140
Query: 132 VNYLHNMTPP-LLHHDLKTQNILLDNEFHV-KIADFGLSKWRMMSLSQSRSSKSAPEGGT 189
V YLH+M P L+H DLK N+LL V KI DFG + ++ ++ G+
Sbjct: 141 VAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--------GS 192
Query: 190 IIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNP-LQIMYSVSQGHRP 248
+M PE +E S S K D++S+ +I WEV++R++PF+++ P +IM++V G RP
Sbjct: 193 AAWMAPEVFEG---SNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRP 249
Query: 249 VINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTF 297
+ ++LP I SL+ W+++P +RPS + + + ++R F
Sbjct: 250 PL-IKNLPKPIE------SLMTRCWSKDPSQRPSMEEIVKIMTHLMRYF 291
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 107 bits (267), Expect = 3e-23
Identities = 90/289 (31%), Positives = 143/289 (49%), Gaps = 32/289 (11%)
Query: 13 IPYHKLADLRYLSRGASGTVSSARHADWRVQ-VAVKHLHIHTPLLDSERKDVLREAEILH 71
I Y ++ + RGA G V A+ WR + VA+K + +SERK + E L
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAK---WRAKDVAIKQIES-----ESERKAFIVELRQLS 82
Query: 72 KARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALG 131
+ I+ + G C P L V EY GSL +LH P + + G
Sbjct: 83 RVNHPNIVKLYGACLNPVCL--VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 140
Query: 132 VNYLHNMTPP-LLHHDLKTQNILLDNEFHV-KIADFGLSKWRMMSLSQSRSSKSAPEGGT 189
V YLH+M P L+H DLK N+LL V KI DFG + ++ ++ G+
Sbjct: 141 VAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--------GS 192
Query: 190 IIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNP-LQIMYSVSQGHRP 248
+M PE +E S S K D++S+ +I WEV++R++PF+++ P +IM++V G RP
Sbjct: 193 AAWMAPEVFEG---SNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRP 249
Query: 249 VINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTF 297
+ ++LP I SL+ W+++P +RPS + + + ++R F
Sbjct: 250 PL-IKNLPKPIE------SLMTRCWSKDPSQRPSMEEIVKIMTHLMRYF 291
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 107 bits (267), Expect = 3e-23
Identities = 90/289 (31%), Positives = 143/289 (49%), Gaps = 32/289 (11%)
Query: 13 IPYHKLADLRYLSRGASGTVSSARHADWRVQ-VAVKHLHIHTPLLDSERKDVLREAEILH 71
I Y ++ + RGA G V A+ WR + VA+K + +SERK + E L
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAK---WRAKDVAIKQIES-----ESERKAFIVELRQLS 82
Query: 72 KARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALG 131
+ I+ + G C P L V EY GSL +LH P + + G
Sbjct: 83 RVNHPNIVKLYGACLNPVCL--VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQG 140
Query: 132 VNYLHNMTPP-LLHHDLKTQNILLDNEFHV-KIADFGLSKWRMMSLSQSRSSKSAPEGGT 189
V YLH+M P L+H DLK N+LL V KI DFG + ++ ++ G+
Sbjct: 141 VAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNK--------GS 192
Query: 190 IIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNP-LQIMYSVSQGHRP 248
+M PE +E S S K D++S+ +I WEV++R++PF+++ P +IM++V G RP
Sbjct: 193 AAWMAPEVFEG---SNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRP 249
Query: 249 VINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTF 297
+ ++LP I SL+ W+++P +RPS + + + ++R F
Sbjct: 250 PL-IKNLPKPIE------SLMTRCWSKDPSQRPSMEEIVKIMTHLMRYF 291
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 103 bits (256), Expect = 5e-22
Identities = 82/308 (26%), Positives = 146/308 (47%), Gaps = 22/308 (7%)
Query: 26 RGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGIC 85
R SG+ + W VAVK L++ P + + E +L K R IL +G
Sbjct: 462 RIGSGSFGTVYKGKWHGDVAVKMLNVTAPT-PQQLQAFKNEVGVLRKTRHVNILLFMGYS 520
Query: 86 NEPEFLGIVTEYMPNGSLNELLHR-KTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLH 144
+P+ L IVT++ SL LH +T++ + I + A G++YLH + ++H
Sbjct: 521 TKPQ-LAIVTQWCEGSSLYHHLHIIETKFEMIKL---IDIARQTAQGMDYLHAKS--IIH 574
Query: 145 HDLKTQNILLDNEFHVKIADFGL----SKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEP 200
DLK+ NI L + VKI DFGL S+W S S + G+I++M PE
Sbjct: 575 RDLKSNNIFLHEDLTVKIGDFGLATVKSRW-------SGSHQFEQLSGSILWMAPEVIRM 627
Query: 201 GQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIP 260
K+ S + D+Y++ ++ +E+++ + P+ ++ N QI++ V +G+ ++ +
Sbjct: 628 QDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGY---LSPDLSKVRSN 684
Query: 261 HRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSA 320
M L+ + DERP F + L +E + R+ +I + L + Q+ +
Sbjct: 685 CPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFS 744
Query: 321 IHLCDKKK 328
++ C K
Sbjct: 745 LYACASPK 752
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 99.8 bits (247), Expect = 6e-21
Identities = 77/282 (27%), Positives = 135/282 (47%), Gaps = 22/282 (7%)
Query: 15 YHKLADLRYLS--RGASGTVSSARHADWRVQVAVKHL--------HIHTPLLDSERKDVL 64
YHK A R RG+S H +++ H H++ ++ R+ VL
Sbjct: 507 YHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQ-VL 565
Query: 65 REAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRI 124
E + + +F+++ +G C +P + IVTEY P GSL ++L + + ++ W R+ +
Sbjct: 566 FELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDIL--ENDSINLDWMFRYSL 623
Query: 125 LHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSA 184
++++ G+ +LHN H LK+ N ++D+ F +KI D+GL+ +R + + A
Sbjct: 624 INDLVKGMAFLHNSIIS-SHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYA 682
Query: 185 PEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPF--EDV-TNPLQIMYS 241
+ T + N P + K D+YS+ +I E+ R PF E + +P +I+
Sbjct: 683 KKLWTAPELLSGNPLP---TTGMQKADVYSFGIILQEIALRSGPFYLEGLDLSPKEIVQK 739
Query: 242 VSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSF 283
V G RP + ++ L+E WAQ+P ERP F
Sbjct: 740 VRNGQRPYFRPSIDRTQL--NEELVLLMERCWAQDPAERPDF 779
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 99.8 bits (247), Expect = 6e-21
Identities = 108/386 (27%), Positives = 172/386 (44%), Gaps = 61/386 (15%)
Query: 17 KLADLRYLSRGASGTVSSARHADWRVQ---VAVKHLHIHTPLLDSERKDVLREAEILHKA 73
K DL++ G+ S A W Q VAVK L + +EAEIL
Sbjct: 12 KFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-----------LKIEKEAEILSVL 60
Query: 74 RFSYILPILGICNEPEFLGIVTEYMPNGSLNELLH-RKTEYPDVAWPLRFRILHEIALGV 132
I+ G+ EP GIVTEY GSL + ++ ++E D+ + + ++A G+
Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT--DVAKGM 118
Query: 133 NYLHNMTP-PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTII 191
+YLH P ++H DLK++N+++ + +KI DFG S++ + S GT
Sbjct: 119 HYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV-------GTFP 171
Query: 192 YMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVIN 251
+M PE Q S D YSY V+ WE+L+R+ PF+ + LQ+ + V + + +
Sbjct: 172 WMAPEVI---QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG-LQVAWLVVEKNERLTI 227
Query: 252 EESLPYDI---------------PHRARMISLIE--SGWAQNPDERPSFL------KCLI 288
S P P ++IS++E S PD+ SFL +C I
Sbjct: 228 PSSCPRSFAELLHQCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEI 287
Query: 289 ELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELS---LNIPVNHGPQEES 345
E T E + LE + K+ +L+ + + ++K E S L +P+ EES
Sbjct: 288 E-----ATLERLKKLERDLSFKEQELKERERRLKMWEQKLTEQSNTPLLLPLAARMSEES 342
Query: 346 CGSSQLHENSGSPETSRSLPAPQDND 371
S+ E S S E S + A + +
Sbjct: 343 YFESKT-EESNSAEMSCQITATSNGE 367
>gi|4758696 mitogen-activated protein kinase kinase kinase 13 [Homo
sapiens]
Length = 966
Score = 99.8 bits (247), Expect = 6e-21
Identities = 94/329 (28%), Positives = 154/329 (46%), Gaps = 52/329 (15%)
Query: 13 IPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHK 72
+P+ ++++L++L GA G V + +VA+K + R+ + + L K
Sbjct: 163 VPFEEISELQWLGSGAQGAVFLGKFR--AEEVAIKKV----------REQNETDIKHLRK 210
Query: 73 ARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPD---VAWPLRFRILHEIA 129
+ I+ G+C + I+ EY +G L E+L + V W IA
Sbjct: 211 LKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTG------IA 264
Query: 130 LGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGT 189
G+NYLH ++H DLK+ N+L+ + VKI+DFG SK S S GT
Sbjct: 265 SGMNYLH--LHKIIHRDLKSPNVLVTHTDAVKISDFGTSK------ELSDKSTKMSFAGT 316
Query: 190 IIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQG--HR 247
+ +M PE + S K DI+S+ V+ WE+L+ + P++DV + I++ V H
Sbjct: 317 VAWMAPEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSS-AIIWGVGSNSLHL 372
Query: 248 PVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELE----PVLRTFEEITF- 302
PV P P ++ L++ W P RPSF + L+ L+ VL T +E F
Sbjct: 373 PV------PSTCPDGFKI--LMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFK 424
Query: 303 --LEAVIQLKK--TKLQSVSSAIHLCDKK 327
E ++KK K++S + IH D++
Sbjct: 425 SQAEWREEVKKHFEKIKSEGTCIHRLDEE 453
>gi|68800350 interleukin-1 receptor-associated kinase 1 isoform 3
[Homo sapiens]
Length = 633
Score = 99.0 bits (245), Expect = 1e-20
Identities = 63/186 (33%), Positives = 101/186 (54%), Gaps = 9/186 (4%)
Query: 45 AVKHLHIHTPL-LDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSL 103
AVK L + L + ++ L E E L + R I+ G C + F +V ++PNGSL
Sbjct: 237 AVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSL 296
Query: 104 NELLHRKTEY-PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKI 162
+ LH +T+ P ++WP R IL A + +LH +P L+H D+K+ N+LLD K+
Sbjct: 297 EDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKL 356
Query: 163 ADFGLSKW-RMMSLSQSRSS---KSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVI 218
DFGL+++ R S S+SS ++ GT+ Y+P E + G R ++ D +S+ V+
Sbjct: 357 GDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTG---RLAVDTDTFSFGVV 413
Query: 219 TWEVLS 224
E L+
Sbjct: 414 VLETLA 419
>gi|68800343 interleukin-1 receptor-associated kinase 1 isoform 2
[Homo sapiens]
Length = 682
Score = 99.0 bits (245), Expect = 1e-20
Identities = 63/186 (33%), Positives = 101/186 (54%), Gaps = 9/186 (4%)
Query: 45 AVKHLHIHTPL-LDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSL 103
AVK L + L + ++ L E E L + R I+ G C + F +V ++PNGSL
Sbjct: 237 AVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSL 296
Query: 104 NELLHRKTEY-PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKI 162
+ LH +T+ P ++WP R IL A + +LH +P L+H D+K+ N+LLD K+
Sbjct: 297 EDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKL 356
Query: 163 ADFGLSKW-RMMSLSQSRSS---KSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVI 218
DFGL+++ R S S+SS ++ GT+ Y+P E + G R ++ D +S+ V+
Sbjct: 357 GDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTG---RLAVDTDTFSFGVV 413
Query: 219 TWEVLS 224
E L+
Sbjct: 414 VLETLA 419
>gi|68800243 interleukin-1 receptor-associated kinase 1 isoform 1
[Homo sapiens]
Length = 712
Score = 99.0 bits (245), Expect = 1e-20
Identities = 63/186 (33%), Positives = 101/186 (54%), Gaps = 9/186 (4%)
Query: 45 AVKHLHIHTPL-LDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSL 103
AVK L + L + ++ L E E L + R I+ G C + F +V ++PNGSL
Sbjct: 237 AVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSL 296
Query: 104 NELLHRKTEY-PDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKI 162
+ LH +T+ P ++WP R IL A + +LH +P L+H D+K+ N+LLD K+
Sbjct: 297 EDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKL 356
Query: 163 ADFGLSKW-RMMSLSQSRSS---KSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVI 218
DFGL+++ R S S+SS ++ GT+ Y+P E + G R ++ D +S+ V+
Sbjct: 357 GDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTG---RLAVDTDTFSFGVV 413
Query: 219 TWEVLS 224
E L+
Sbjct: 414 VLETLA 419
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 98.2 bits (243), Expect = 2e-20
Identities = 94/332 (28%), Positives = 152/332 (45%), Gaps = 58/332 (17%)
Query: 13 IPYHKLADLRYLSRGASGTVSSAR-HADWRVQVAVKHLHIHTPLLDSERKDVLREAEILH 71
+P+ ++ DL+++ GA G V R H + +VAVK + L+E +I H
Sbjct: 120 VPFEEILDLQWVGSGAQGAVFLGRFHGE---EVAVKKVRD------------LKETDIKH 164
Query: 72 --KARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPD---VAWPLRFRILH 126
K + I+ G+C + I+ E+ G L E+L V W +
Sbjct: 165 LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMG----- 219
Query: 127 EIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPE 186
IA G+NYLH ++H DLK+ N+L+ + VKI+DFG SK S S
Sbjct: 220 -IAGGMNYLH--LHKIIHRDLKSPNMLITYDDVVKISDFGTSK------ELSDKSTKMSF 270
Query: 187 GGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQG- 245
GT+ +M PE + S K DI+S+ V+ WE+L+ + P++DV + I++ V
Sbjct: 271 AGTVAWMAPEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSS-AIIWGVGSNS 326
Query: 246 -HRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELE----PVLRTFEEI 300
H PV P P ++ L+ W P RPSF + L+ L+ VL T +E
Sbjct: 327 LHLPV------PSSCPDGFKI--LLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQET 378
Query: 301 TFLEAV-----IQLKKTKLQSVSSAIHLCDKK 327
F ++L K++S + +H +++
Sbjct: 379 YFKSQAEWREEVKLHFEKIKSEGTCLHRLEEE 410
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 98.2 bits (243), Expect = 2e-20
Identities = 75/287 (26%), Positives = 136/287 (47%), Gaps = 29/287 (10%)
Query: 19 ADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYI 78
++L ++ SG R WR Q V I + E D + EA+++ K +
Sbjct: 368 SELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEE--DFIEEAKVMMKLTHPKL 425
Query: 79 LPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNM 138
+ + G+C + + + IVTE+M G L L ++ + + + + ++ G+ YL
Sbjct: 426 VQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGH--FSRDVLLSMCQDVCEGMEYLERN 483
Query: 139 TPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENY 198
+ +H DL +N L+ VK++DFG++++ + S S P + + PPE +
Sbjct: 484 S--FIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFP----VKWCPPEVF 537
Query: 199 EPGQKSRASIKHDIYSYAVITWEVLSR-KQPFEDVTNPLQIMYSVSQGHRPVINEESLPY 257
SR S K D++S+ V+ WEV + + PFE TN +++ V++GHR + + Y
Sbjct: 538 N---YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTN-YEVVTMVTRGHRLYQPKLASNY 593
Query: 258 DIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLE 304
+ ++ W + P+ RPSF E +LRT +E+ E
Sbjct: 594 -------VYEVMLRCWQEKPEGRPSF-------EDLLRTIDELVECE 626
>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
[Homo sapiens]
Length = 312
Score = 97.8 bits (242), Expect = 2e-20
Identities = 81/263 (30%), Positives = 129/263 (49%), Gaps = 30/263 (11%)
Query: 30 GTVSSARHADWR-----VQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGI 84
G S R +R + VA+K L T D+E +++REA+I+H+ YI+ ++G+
Sbjct: 40 GNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE--EMMREAQIMHQLDNPYIVRLIGV 97
Query: 85 CNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLH 144
C + E L +V E G L++ L K E V+ +LH++++G+ YL +H
Sbjct: 98 C-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAE--LLHQVSMGMKYLEEKN--FVH 152
Query: 145 HDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPG--Q 202
DL +N+LL N + KI+DFGLSK +L S +A G P + Y P
Sbjct: 153 RDLAARNVLLVNRHYAKISDFGLSK----ALGADDSYYTARSAGK---WPLKWYAPECIN 205
Query: 203 KSRASIKHDIYSYAVITWEVLSRKQ-PFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPH 261
+ S + D++SY V WE LS Q P++ + P ++M + QG R E P
Sbjct: 206 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQGKRMECPPECPP----- 259
Query: 262 RARMISLIESGWAQNPDERPSFL 284
+ +L+ W ++RP FL
Sbjct: 260 --ELYALMSDCWIYKWEDRPDFL 280
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 97.8 bits (242), Expect = 2e-20
Identities = 81/263 (30%), Positives = 129/263 (49%), Gaps = 30/263 (11%)
Query: 30 GTVSSARHADWR-----VQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGI 84
G S R +R + VA+K L T D+E +++REA+I+H+ YI+ ++G+
Sbjct: 347 GNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTE--EMMREAQIMHQLDNPYIVRLIGV 404
Query: 85 CNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLH 144
C + E L +V E G L++ L K E V+ +LH++++G+ YL +H
Sbjct: 405 C-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAE--LLHQVSMGMKYLEEKN--FVH 459
Query: 145 HDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPG--Q 202
DL +N+LL N + KI+DFGLSK +L S +A G P + Y P
Sbjct: 460 RDLAARNVLLVNRHYAKISDFGLSK----ALGADDSYYTARSAGK---WPLKWYAPECIN 512
Query: 203 KSRASIKHDIYSYAVITWEVLSRKQ-PFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPH 261
+ S + D++SY V WE LS Q P++ + P ++M + QG R E P
Sbjct: 513 FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP-EVMAFIEQGKRMECPPECPP----- 566
Query: 262 RARMISLIESGWAQNPDERPSFL 284
+ +L+ W ++RP FL
Sbjct: 567 --ELYALMSDCWIYKWEDRPDFL 587
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 97.4 bits (241), Expect = 3e-20
Identities = 88/277 (31%), Positives = 135/277 (48%), Gaps = 45/277 (16%)
Query: 43 QVAVKHLHIHTPLLDSER--KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPN 100
+VAVK H P D + ++V +EA++ + I+ + G+C + L +V E+
Sbjct: 167 EVAVKAAR-HDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARG 225
Query: 101 GSLNELLHRKTEYPD--VAWPLRFRILHEIALGVNYLHN-MTPPLLHHDLKTQNIL---- 153
G LN +L K PD V W + +IA G+NYLH+ P++H DLK+ NIL
Sbjct: 226 GPLNRVLSGKRIPPDILVNWAV------QIARGMNYLHDEAIVPIIHRDLKSSNILILQK 279
Query: 154 -----LDNEFHVKIADFGLSK-WRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRAS 207
L N+ +KI DFGL++ W R++K + GT +M PE S+ S
Sbjct: 280 VENGDLSNKI-LKITDFGLAREWH-------RTTKMS-AAGTYAWMAPEVIRASMFSKGS 330
Query: 208 IKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMIS 267
D++SY V+ WE+L+ + PF + + L + Y V+ +N+ +LP
Sbjct: 331 ---DVWSYGVLLWELLTGEVPFRGI-DGLAVAYGVA------MNKLALPIPSTCPEPFAK 380
Query: 268 LIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLE 304
L+E W +P RPSF L + L T EE F E
Sbjct: 381 LMEDCWNPDPHSRPSFTNILDQ----LTTIEESGFFE 413
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 97.1 bits (240), Expect = 4e-20
Identities = 77/284 (27%), Positives = 141/284 (49%), Gaps = 30/284 (10%)
Query: 19 ADLRYLSRGASGTVSSARHADWR--VQVAVKHLHIHTPLLDSERKDVLREAEILHKARFS 76
++L ++ SG +WR +QVA+K ++ + +D + EA+++ K S
Sbjct: 269 SELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGS----MSEEDFIEEAKVMMKLSHS 324
Query: 77 YILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLH 136
++ + G+C + + L IVTE+M NG L L + + + + + +I G+ YL
Sbjct: 325 KLVQLYGVCIQRKPLYIVTEFMENGCL--LNYLRENKGKLRKEMLLSVCQDICEGMEYLE 382
Query: 137 NMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE 196
+H DL +N L+ + VKI+DFG++++ + S P I + PPE
Sbjct: 383 R--NGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFP----IKWSPPE 436
Query: 197 NYEPGQKSRASIKHDIYSYAVITWEVLSR-KQPFEDVTNPLQIMYSVSQGHRPVINEESL 255
+ ++ S K D++S+ V+ WEV + K PFE+ +N LQ++ ++S+G R
Sbjct: 437 VF---LFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSN-LQVVEAISEGFR-------- 484
Query: 256 PYDIPHRARM--ISLIESGWAQNPDERPSFLKCLIELEPVLRTF 297
PH A M ++ S W + P+ RP+F + L + + T+
Sbjct: 485 -LYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW 527
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 97.1 bits (240), Expect = 4e-20
Identities = 85/296 (28%), Positives = 138/296 (46%), Gaps = 43/296 (14%)
Query: 13 IPYHKLADLRYLSRGASGTVSSARHADWR-VQVAVKHLHIHT---PLLDSERKDVLREAE 68
IP+H+L + G G V A WR +VAVK + P + +E+ V +EA
Sbjct: 93 IPFHELQLEEIIGVGGFGKVYRAL---WRGEEVAVKAARLDPEKDPAVTAEQ--VCQEAR 147
Query: 69 ILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVA--WPLRFRILH 126
+ + I+ + G C P L +V EY G+L+ +L + P V W +
Sbjct: 148 LFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAV------ 201
Query: 127 EIALGVNYLHNMTP-PLLHHDLKTQNILLDNEFH--------VKIADFGLSKWRMMSLSQ 177
++A G+NYLHN P P++H DLK+ NIL+ +KI DFGL++ +
Sbjct: 202 QVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR-------E 254
Query: 178 SRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQ 237
+ GT +M PE S++S D++S+ V+ WE+L+ + P+ ++ + L
Sbjct: 255 WHKTTKMSAAGTYAWMAPEVIRLSLFSKSS---DVWSFGVLLWELLTGEVPYREI-DALA 310
Query: 238 IMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPV 293
+ Y V+ +N+ +LP L+E W +P RP F L LE +
Sbjct: 311 VAYGVA------MNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVI 360
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 94.7 bits (234), Expect = 2e-19
Identities = 82/280 (29%), Positives = 130/280 (46%), Gaps = 35/280 (12%)
Query: 17 KLADLRYLSRGASGTVSSARHADWRVQ---VAVKHLHIHTPLLDSERKDVLREAEILHKA 73
K DL++ G+ S A W Q VAVK L + +EAEIL
Sbjct: 12 KFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-----------LKIEKEAEILSVL 60
Query: 74 RFSYILPILGICNEPEFLGIVTEYMPNGSLNELLH-RKTEYPDVAWPLRFRILHEIALGV 132
I+ G+ EP GIVTEY GSL + ++ ++E D+ + + ++A G+
Sbjct: 61 SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT--DVAKGM 118
Query: 133 NYLHNMTP-PLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTII 191
+YLH P ++H DLK++N+++ + +KI DFG S++ + S GT
Sbjct: 119 HYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLV-------GTFP 171
Query: 192 YMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVIN 251
+M PE Q S D YSY V+ WE+L+R+ PF+ + LQ+ + V + + +
Sbjct: 172 WMAPEVI---QSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG-LQVAWLVVEKNERLTI 227
Query: 252 EESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELE 291
S P L+ W + +RPSF + + LE
Sbjct: 228 PSSCP------RSFAELLHQCWEADAKKRPSFKQIISILE 261
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 91.3 bits (225), Expect = 2e-18
Identities = 93/309 (30%), Positives = 139/309 (44%), Gaps = 46/309 (14%)
Query: 11 PTIPYHKLADLRYLSR--GASGTVSSARHADWRVQ-VAVKHLHIHTPLLDSER--KDVLR 65
P+ P H + L GA G A W+ Q VAVK P D+ + V R
Sbjct: 113 PSSPVHVAFERLELKELIGAGG-FGQVYRATWQGQEVAVKAAR-QDPEQDAAAAAESVRR 170
Query: 66 EAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPD--VAWPLRFR 123
EA + R I+ + G+C + L +V E+ G+LN L PD P R R
Sbjct: 171 EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRAR 230
Query: 124 ILH---------EIALGVNYLHNMT-PPLLHHDLKTQNILLDNEFH--------VKIADF 165
+ +IA G+ YLH P+LH DLK+ NILL + +KI DF
Sbjct: 231 RIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDF 290
Query: 166 GLSK-WRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLS 224
GL++ W R++K + GT +M PE + S+ S DI+SY V+ WE+L+
Sbjct: 291 GLAREWH-------RTTKMS-TAGTYAWMAPEVIKSSLFSKGS---DIWSYGVLLWELLT 339
Query: 225 RKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFL 284
+ P+ + + L + Y V+ +N+ +LP L++ W Q+P RPSF
Sbjct: 340 GEVPYRGI-DGLAVAYGVA------VNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFA 392
Query: 285 KCLIELEPV 293
L +L +
Sbjct: 393 LILEQLTAI 401
>gi|4502193 v-raf murine sarcoma 3611 viral oncogene homolog [Homo
sapiens]
Length = 606
Score = 90.1 bits (222), Expect = 5e-18
Identities = 78/310 (25%), Positives = 143/310 (46%), Gaps = 17/310 (5%)
Query: 13 IPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHK 72
+P ++ L+ + G+ GTV R W VAVK L + P + + + E ++L K
Sbjct: 305 VPPSEVQLLKRIGTGSFGTVFRGR---WHGDVAVKVLKVSQPTAE-QAQAFKNEMQVLRK 360
Query: 73 ARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGV 132
R IL +G P F I+T++ SL LH D+ + + + A G+
Sbjct: 361 TRHVNILLFMGFMTRPGF-AIITQWCEGSSLYHHLHVADTRFDMVQLID--VARQTAQGM 417
Query: 133 NYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIY 192
+YLH ++H DLK+ NI L VKI DFGL+ + S + G++++
Sbjct: 418 DYLHAKN--IIHRDLKSNNIFLHEGLTVKIGDFGLAT---VKTRWSGAQPLEQPSGSVLW 472
Query: 193 MPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGH-RPVIN 251
M E + S + D+Y+Y V+ +E+++ P+ + QI++ V +G+ P ++
Sbjct: 473 MAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLS 532
Query: 252 EESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKK 311
+ + + P R L+ +ERP F + L +E + R+ +I + L +
Sbjct: 533 K--ISSNCPKAMR--RLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHR 588
Query: 312 TKLQSVSSAI 321
T+ + + +
Sbjct: 589 TQADELPACL 598
>gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 89.7 bits (221), Expect = 6e-18
Identities = 61/202 (30%), Positives = 105/202 (51%), Gaps = 11/202 (5%)
Query: 44 VAVKHLHIHTPLLDSERKDVL-REAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGS 102
VAVK L + E K +E +++ K + ++ +LG ++ + L +V YMPNGS
Sbjct: 86 VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGS 145
Query: 103 LNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKI 162
L + L P ++W +R +I A G+N+LH +H D+K+ NILLD F KI
Sbjct: 146 LLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKI 203
Query: 163 ADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEV 222
+DFGL++ S +++ ++ GT YM PE + + K DIYS+ V+ E+
Sbjct: 204 SDFGLAR---ASEKFAQTVMTSRIVGTTAYMAPE----ALRGEITPKSDIYSFGVVLLEI 256
Query: 223 LSRKQPFEDVTNPLQIMYSVSQ 244
++ ++ P Q++ + +
Sbjct: 257 ITGLPAVDEHREP-QLLLDIKE 277
>gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 89.7 bits (221), Expect = 6e-18
Identities = 61/202 (30%), Positives = 105/202 (51%), Gaps = 11/202 (5%)
Query: 44 VAVKHLHIHTPLLDSERKDVL-REAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGS 102
VAVK L + E K +E +++ K + ++ +LG ++ + L +V YMPNGS
Sbjct: 86 VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGS 145
Query: 103 LNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKI 162
L + L P ++W +R +I A G+N+LH +H D+K+ NILLD F KI
Sbjct: 146 LLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH--IHRDIKSANILLDEAFTAKI 203
Query: 163 ADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEV 222
+DFGL++ S +++ ++ GT YM PE + + K DIYS+ V+ E+
Sbjct: 204 SDFGLAR---ASEKFAQTVMTSRIVGTTAYMAPE----ALRGEITPKSDIYSFGVVLLEI 256
Query: 223 LSRKQPFEDVTNPLQIMYSVSQ 244
++ ++ P Q++ + +
Sbjct: 257 ITGLPAVDEHREP-QLLLDIKE 277
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,571,557
Number of Sequences: 37866
Number of extensions: 967829
Number of successful extensions: 3911
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 534
Number of HSP's successfully gapped in prelim test: 197
Number of HSP's that attempted gapping in prelim test: 2690
Number of HSP's gapped (non-prelim): 804
length of query: 540
length of database: 18,247,518
effective HSP length: 107
effective length of query: 433
effective length of database: 14,195,856
effective search space: 6146805648
effective search space used: 6146805648
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.