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Search of human proteins with 4506101
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
(438 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [... 883 0.0
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ... 875 0.0
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 246 4e-65
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi... 238 6e-63
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi... 207 1e-53
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 197 1e-50
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 197 1e-50
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens] 188 1e-47
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 166 5e-41
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 166 5e-41
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 162 6e-40
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 162 6e-40
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 158 8e-39
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 157 1e-38
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi... 157 1e-38
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 150 2e-36
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 141 1e-33
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 140 3e-33
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 140 3e-33
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 140 3e-33
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 140 3e-33
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 140 3e-33
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 140 3e-33
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 140 3e-33
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 140 3e-33
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 138 9e-33
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 137 1e-32
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 132 6e-31
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 132 6e-31
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 132 6e-31
>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
Length = 438
Score = 883 bits (2281), Expect = 0.0
Identities = 438/438 (100%), Positives = 438/438 (100%)
Query: 1 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF 60
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
Sbjct: 1 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF 60
Query: 61 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL 120
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
Sbjct: 61 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL 120
Query: 121 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV 180
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
Sbjct: 121 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV 180
Query: 181 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC 240
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
Sbjct: 181 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC 240
Query: 241 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC 300
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
Sbjct: 241 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC 300
Query: 301 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMPLQ 360
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMPLQ
Sbjct: 301 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMPLQ 360
Query: 361 LLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVV 420
LLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVV
Sbjct: 361 LLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVV 420
Query: 421 SMWVCRALEERRSQQGPP 438
SMWVCRALEERRSQQGPP
Sbjct: 421 SMWVCRALEERRSQQGPP 438
>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
Length = 448
Score = 875 bits (2260), Expect = 0.0
Identities = 438/448 (97%), Positives = 438/448 (97%), Gaps = 10/448 (2%)
Query: 1 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF 60
MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF
Sbjct: 1 MLWLALGPFPAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAF 60
Query: 61 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL 120
EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL
Sbjct: 61 EYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGL 120
Query: 121 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV 180
KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV
Sbjct: 121 KVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTV 180
Query: 181 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC 240
YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC
Sbjct: 181 YKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISIC 240
Query: 241 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC 300
TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC
Sbjct: 241 TEFMDGGSLDVYRKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLC 300
Query: 301 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFME----------IQ 350
DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFME IQ
Sbjct: 301 DFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQ 360
Query: 351 KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 410
KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV
Sbjct: 361 KNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIV 420
Query: 411 QFNDGNAAVVSMWVCRALEERRSQQGPP 438
QFNDGNAAVVSMWVCRALEERRSQQGPP
Sbjct: 421 QFNDGNAAVVSMWVCRALEERRSQQGPP 448
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 246 bits (627), Expect = 4e-65
Identities = 134/339 (39%), Positives = 195/339 (57%), Gaps = 51/339 (15%)
Query: 140 LPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL 199
L K+ A L + G++ + D LG GNGG V+K H PSG ++A K+I L
Sbjct: 42 LDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL 101
Query: 200 DITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRK----M 255
+I ++ QI+ EL++L++C+S YI+GFYGAF+ + ISIC E MDGGSLD K +
Sbjct: 102 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRI 161
Query: 256 PEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK 314
PE +LG++++AV+KGLTYL KI+HRDVKPSN+LVN+RG++KLCDFGVS QL++S+A
Sbjct: 162 PEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 221
Query: 315 TYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMP---------------- 358
++VGT +YM+PER+ G Y + SD+WS+G+S +E+ + + P
Sbjct: 222 SFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEG 281
Query: 359 -----------------------------LQLLQCIVDEDSPVLPVGEFSEPFVHFITQC 389
+LL IV+E P LP G FS F F+ +C
Sbjct: 282 DAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKC 341
Query: 390 MRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRAL 428
+ K P ER ++LM H FI + +D + W+C +
Sbjct: 342 LIKNPAERADLKQLMVHAFIKR-SDAEEVDFAGWLCSTI 379
>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
Length = 400
Score = 238 bits (608), Expect = 6e-63
Identities = 134/353 (37%), Positives = 198/353 (56%), Gaps = 57/353 (16%)
Query: 140 LPSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL 199
L K+ A L + G++ + D LG GNGG V K H PSG I+A K+I L
Sbjct: 46 LDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHL 105
Query: 200 DITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVY----RKM 255
+I ++ QI+ EL++L++C+S YI+GFYGAF+ + ISIC E MDGGSLD +++
Sbjct: 106 EIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRI 165
Query: 256 PEHVLGRIAVAVVKGLTYLWSL-KILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK 314
PE +LG++++AV++GL YL +I+HRDVKPSN+LVN+RG++KLCDFGVS QL++S+A
Sbjct: 166 PEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN 225
Query: 315 TYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMP---------------- 358
++VGT +YMAPER+ G Y + SD+WS+G+S +E+ + + P
Sbjct: 226 SFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVD 285
Query: 359 ---------------------------------LQLLQCIVDEDSPVLPVGEFSEPFVHF 385
+LL IV+E P LP G F+ F F
Sbjct: 286 GEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEF 345
Query: 386 ITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP 438
+ +C+ K P ER + L H FI + ++ + W+C+ L R +Q G P
Sbjct: 346 VNKCLIKNPAERADLKMLTNHTFIKR-SEVEEVDFAGWLCKTL--RLNQPGTP 395
>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
Length = 334
Score = 207 bits (528), Expect = 1e-53
Identities = 133/330 (40%), Positives = 186/330 (56%), Gaps = 30/330 (9%)
Query: 113 GERNIHGLKVNTRAGPSQHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDTL 172
G++ GLK+ A P S + P + K+ + N ++ D+ L
Sbjct: 6 GKKRNPGLKIPKEA----FEQPQTSSTPPRDLDSKACISIGN--QNFEVKADDLEPIMEL 59
Query: 173 GHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAF 231
G G G V K HVPSG+I+AVK I + + QK+++ +L+I + D + + FYGA
Sbjct: 60 GRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGAL 119
Query: 232 FVENRISICTEFMDGGSLDVYRK--------MPEHVLGRIAVAVVKGLTYLWS-LKILHR 282
F E + IC E MD SLD + K +PE +LG+IAV++VK L +L S L ++HR
Sbjct: 120 FREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHR 178
Query: 283 DVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERISGE----QYGIHS 337
DVKPSN+L+N GQVK+CDFG+S LV+S+AKT G YMAPERI+ E Y + S
Sbjct: 179 DVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKS 238
Query: 338 DVWSLGISFMEI------QKNQGSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMR 391
D+WSLGI+ +E+ + G+ P Q L+ +V+E SP LP +FS FV F +QC++
Sbjct: 239 DIWSLGITMIELAILRFPYDSWGT--PFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLK 296
Query: 392 KQPKERPAPEELMGHPFIVQFNDGNAAVVS 421
K KERP ELM HPF V S
Sbjct: 297 KNSKERPTYPELMQHPFFTLHESKGTDVAS 326
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 197 bits (502), Expect = 1e-50
Identities = 119/271 (43%), Positives = 160/271 (59%), Gaps = 22/271 (8%)
Query: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
N ++ D+ LG G G V K H SG I+AVK I + + QK+++ +L+I +
Sbjct: 27 NFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINM 86
Query: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 87 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 146
Query: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AKT G YMAPER
Sbjct: 147 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER 206
Query: 328 ISGE----QYGIHSDVWSLGISFMEI------QKNQGSLMPLQLLQCIVDEDSPVLPVGE 377
I+ E Y + SDVWSLGI+ +E+ ++ G+ P Q L+ +V+E SP LP
Sbjct: 207 INPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGT--PFQQLKQVVEEPSPQLPADR 264
Query: 378 FSEPFVHFITQCMRKQPKERPAPEELMGHPF 408
FS FV F QC+RK P ER + ELM HPF
Sbjct: 265 FSPEFVDFTAQCLRKNPAERMSYLELMEHPF 295
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 197 bits (502), Expect = 1e-50
Identities = 119/271 (43%), Positives = 160/271 (59%), Gaps = 22/271 (8%)
Query: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
N ++ D+ LG G G V K H SG I+AVK I + + QK+++ +L+I +
Sbjct: 56 NFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINM 115
Query: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 116 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 175
Query: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AKT G YMAPER
Sbjct: 176 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER 235
Query: 328 ISGE----QYGIHSDVWSLGISFMEI------QKNQGSLMPLQLLQCIVDEDSPVLPVGE 377
I+ E Y + SDVWSLGI+ +E+ ++ G+ P Q L+ +V+E SP LP
Sbjct: 236 INPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGT--PFQQLKQVVEEPSPQLPADR 293
Query: 378 FSEPFVHFITQCMRKQPKERPAPEELMGHPF 408
FS FV F QC+RK P ER + ELM HPF
Sbjct: 294 FSPEFVDFTAQCLRKNPAERMSYLELMEHPF 324
>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
Length = 399
Score = 188 bits (477), Expect = 1e-47
Identities = 120/300 (40%), Positives = 175/300 (58%), Gaps = 29/300 (9%)
Query: 164 QDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSS 222
+D++ +G G G+V K H PSG+I+AVK I + + QKQ++ +L+++ + D
Sbjct: 100 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 159
Query: 223 YIIGFYGAFFVENRISICTEFMDGGSLDVYRK---------MPEHVLGRIAVAVVKGLTY 273
YI+ FYGA F E IC E M S D + K +PE +LG+I +A VK L +
Sbjct: 160 YIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 218
Query: 274 LW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERI--- 328
L +LKI+HRD+KPSN+L++ G +KLCDFG+S QLV+SIAKT G YMAPERI
Sbjct: 219 LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS 278
Query: 329 -SGEQYGIHSDVWSLGISFMEIQKNQ------GSLMPLQLLQCIVDEDSPVLPVG---EF 378
S + Y + SDVWSLGI+ E+ + S+ QL Q +V D P L EF
Sbjct: 279 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFD-QLTQ-VVKGDPPQLSNSEEREF 336
Query: 379 SEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP 438
S F++F+ C+ K +RP +EL+ HPFI+ + + A V+ +VC+ L++ + P
Sbjct: 337 SPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEE-RAVEVACYVCKILDQMPATPSSP 395
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 166 bits (419), Expect = 5e-41
Identities = 93/250 (37%), Positives = 153/250 (61%), Gaps = 9/250 (3%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYG 229
+ +G G+ G V+K + +++A+K+I L+ + + I E+ +L +CDSSY+ +YG
Sbjct: 28 ERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYG 87
Query: 230 AFFVENRISICTEFMDGGS-LDVYRKMP--EHVLGRIAVAVVKGLTYLWSLKILHRDVKP 286
++ +++ I E++ GGS LD+ R P E + + ++KGL YL S K +HRD+K
Sbjct: 88 SYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKA 147
Query: 287 SNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHSDVWSLGI 344
+N+L++ +G VKL DFGV+ QL ++ K T+VGT +MAPE I Y +D+WSLGI
Sbjct: 148 ANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGI 207
Query: 345 SFMEIQKNQ---GSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPE 401
+ +E+ K + + P+++L I + P L VG+F++ F FI C+ K P RP +
Sbjct: 208 TAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL-VGDFTKSFKEFIDACLNKDPSFRPTAK 266
Query: 402 ELMGHPFIVQ 411
EL+ H FIV+
Sbjct: 267 ELLKHKFIVK 276
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 166 bits (419), Expect = 5e-41
Identities = 91/251 (36%), Positives = 153/251 (60%), Gaps = 9/251 (3%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYG 229
D +G G+ G VYK + +++A+K+I L+ + + I E+ +L +CDS YI ++G
Sbjct: 24 DRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFG 83
Query: 230 AFFVENRISICTEFMDGGS-LDVYRKMP--EHVLGRIAVAVVKGLTYLWSLKILHRDVKP 286
++ ++ I E++ GGS LD+ + P E + I ++KGL YL S + +HRD+K
Sbjct: 84 SYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKA 143
Query: 287 SNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHSDVWSLGI 344
+N+L++ +G VKL DFGV+ QL ++ K T+VGT +MAPE I Y +D+WSLGI
Sbjct: 144 ANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGI 203
Query: 345 SFMEIQKNQ---GSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPE 401
+ +E+ K + L P+++L ++ ++SP G+ S+PF F+ C+ K P+ RP +
Sbjct: 204 TAIELAKGEPPNSDLHPMRVL-FLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAK 262
Query: 402 ELMGHPFIVQF 412
EL+ H FI ++
Sbjct: 263 ELLKHKFITRY 273
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 162 bits (410), Expect = 6e-40
Identities = 90/250 (36%), Positives = 150/250 (60%), Gaps = 9/250 (3%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYG 229
+ +G G+ G V+K + K++A+K+I L+ + + I E+ +L +CDS Y+ +YG
Sbjct: 28 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYG 87
Query: 230 AFFVENRISICTEFMDGGS-LDVYRKMP--EHVLGRIAVAVVKGLTYLWSLKILHRDVKP 286
++ + ++ I E++ GGS LD+ P E + I ++KGL YL S K +HRD+K
Sbjct: 88 SYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKA 147
Query: 287 SNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHSDVWSLGI 344
+N+L++ G+VKL DFGV+ QL ++ K T+VGT +MAPE I Y +D+WSLGI
Sbjct: 148 ANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGI 207
Query: 345 SFMEIQKNQ---GSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPE 401
+ +E+ + + L P+++L I + P L G +S+P F+ C+ K+P RP +
Sbjct: 208 TAIELARGEPPHSELHPMKVLFLIPKNNPPTLE-GNYSKPLKEFVEACLNKEPSFRPTAK 266
Query: 402 ELMGHPFIVQ 411
EL+ H FI++
Sbjct: 267 ELLKHKFILR 276
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 162 bits (410), Expect = 6e-40
Identities = 90/250 (36%), Positives = 150/250 (60%), Gaps = 9/250 (3%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYG 229
+ +G G+ G V+K + K++A+K+I L+ + + I E+ +L +CDS Y+ +YG
Sbjct: 40 EKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYG 99
Query: 230 AFFVENRISICTEFMDGGS-LDVYRKMP--EHVLGRIAVAVVKGLTYLWSLKILHRDVKP 286
++ + ++ I E++ GGS LD+ P E + I ++KGL YL S K +HRD+K
Sbjct: 100 SYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKA 159
Query: 287 SNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHSDVWSLGI 344
+N+L++ G+VKL DFGV+ QL ++ K T+VGT +MAPE I Y +D+WSLGI
Sbjct: 160 ANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGI 219
Query: 345 SFMEIQKNQ---GSLMPLQLLQCIVDEDSPVLPVGEFSEPFVHFITQCMRKQPKERPAPE 401
+ +E+ + + L P+++L I + P L G +S+P F+ C+ K+P RP +
Sbjct: 220 TAIELARGEPPHSELHPMKVLFLIPKNNPPTLE-GNYSKPLKEFVEACLNKEPSFRPTAK 278
Query: 402 ELMGHPFIVQ 411
EL+ H FI++
Sbjct: 279 ELLKHKFILR 288
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 158 bits (400), Expect = 8e-39
Identities = 93/280 (33%), Positives = 160/280 (57%), Gaps = 19/280 (6%)
Query: 141 PSNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLD 200
P + LKK S + + + E+ + LG G+ G+V+KA H SG+++A+K + ++
Sbjct: 7 PKSKLKKLSED-----SLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE 61
Query: 201 ITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSL-DVYR----KM 255
L+ +I+ E+ I+ +CDS Y++ +YG++F + I E+ GS+ D+ R +
Sbjct: 62 SDLQ---EIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTL 118
Query: 256 PEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK- 314
E + I + +KGL YL ++ +HRD+K N+L+NT G KL DFGV+ QL +++AK
Sbjct: 119 IEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR 178
Query: 315 -TYVGTNAYMAPERISGEQYGIHSDVWSLGISFMEIQKNQ---GSLMPLQLLQCIVDEDS 370
T +GT +MAPE I Y +D+WSLGI+ +E+ + + + P++ + I
Sbjct: 179 NTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPP 238
Query: 371 PVLPVGE-FSEPFVHFITQCMRKQPKERPAPEELMGHPFI 409
P E +S+ F F+ +C+ K P++R +L+ HPFI
Sbjct: 239 PTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 278
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 157 bits (398), Expect = 1e-38
Identities = 87/251 (34%), Positives = 149/251 (59%), Gaps = 14/251 (5%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYG 229
+ LG G+ G+VYKA H +G+I+A+K + ++ L+ +I+ E+ I+ +CDS +++ +YG
Sbjct: 34 EKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQ---EIIKEISIMQQCDSPHVVKYYG 90
Query: 230 AFFVENRISICTEFMDGGSL-DVYR----KMPEHVLGRIAVAVVKGLTYLWSLKILHRDV 284
++F + I E+ GS+ D+ R + E + I + +KGL YL ++ +HRD+
Sbjct: 91 SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDI 150
Query: 285 KPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHSDVWSL 342
K N+L+NT G KL DFGV+ QL +++AK T +GT +MAPE I Y +D+WSL
Sbjct: 151 KAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSL 210
Query: 343 GISFMEIQKNQ---GSLMPLQLLQCIVDEDSPVLPVGE-FSEPFVHFITQCMRKQPKERP 398
GI+ +E+ + + + P++ + I P E +S+ F F+ QC+ K P++R
Sbjct: 211 GITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRA 270
Query: 399 APEELMGHPFI 409
+L+ HPF+
Sbjct: 271 TATQLLQHPFV 281
>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
Length = 419
Score = 157 bits (398), Expect = 1e-38
Identities = 109/316 (34%), Positives = 169/316 (53%), Gaps = 23/316 (7%)
Query: 128 PSQHSSPAVSDSLP-SNSLKKSSAELKKILANGQMNEQDIRYRDTLGHGNGGT---VYKA 183
PS +P +S+ L++ + + GQ + +I + LG GT V+K
Sbjct: 78 PSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKM 137
Query: 184 YHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSSYIIGFYGAFFVENRISICTE 242
+G ++AVK + E K+I+ +L+++ K D YI+ +G F + I E
Sbjct: 138 RFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAME 197
Query: 243 FMDGGSLDVYRKM----PEHVLGRIAVAVVKGLTYLWSLK-ILHRDVKPSNMLVNTRGQV 297
M + + ++M PE +LG++ VA+VK L YL ++HRDVKPSN+L++ RGQ+
Sbjct: 198 LMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQI 257
Query: 298 KLCDFGVSTQLVNSIAKT-YVGTNAYMAPERI-----SGEQYGIHSDVWSLGISFMEIQK 351
KLCDFG+S +LV+S AKT G AYMAPERI + Y I +DVWSLGIS +E+
Sbjct: 258 KLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELAT 317
Query: 352 NQ----GSLMPLQLLQCIVDEDSPVLP--VGEFSEPFVHFITQCMRKQPKERPAPEELMG 405
Q ++L ++ E+ P+LP +G FS F F+ C+ K ++RP +L+
Sbjct: 318 GQFPYKNCKTDFEVLTKVLQEEPPLLPGHMG-FSGDFQSFVKDCLTKDHRKRPKYNKLLE 376
Query: 406 HPFIVQFNDGNAAVVS 421
H FI ++ V S
Sbjct: 377 HSFIKRYETLEVDVAS 392
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 150 bits (379), Expect = 2e-36
Identities = 89/202 (44%), Positives = 120/202 (59%), Gaps = 14/202 (6%)
Query: 158 NGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-L 216
N ++ D+ LG G G V K H SG I+AVK+I + QK+++ +L+I +
Sbjct: 61 NFEVEADDLVTIPELGRGAYGVVEKVRHTQSGTIMAVKLIWATVNSXEQKRLLMDLDINM 120
Query: 217 YKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKM-------PEHVLGRIAVAVVK 269
D Y + FYGA F E + IC E MD YRK+ PE +LG IAV++V+
Sbjct: 121 RTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVR 180
Query: 270 GLTYLWS-LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPER 327
L +L S L ++HRDVKPSN+L+N G VK+CDFG+S LV+S+AK G YMAPER
Sbjct: 181 ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPER 240
Query: 328 ISGE----QYGIHSDVWSLGIS 345
I+ E Y + SDVWSLGI+
Sbjct: 241 INPELNQKGYNVKSDVWSLGIT 262
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 141 bits (356), Expect = 1e-33
Identities = 84/264 (31%), Positives = 149/264 (56%), Gaps = 16/264 (6%)
Query: 163 EQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSS 222
++D +G G G VYKA +V +G++ A+KVI L+ + + E+ ++ C
Sbjct: 13 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-VQQEIIMMKDCKHP 71
Query: 223 YIIGFYGAFFVENRISICTEFMDGGSL-DVYR---KMPEHVLGRIAVAVVKGLTYLWSLK 278
I+ ++G++ +++ IC EF GGSL D+Y + E + ++ ++GL YL S
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKG 131
Query: 279 ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIA--KTYVGTNAYMAPERISGEQYGIH 336
+HRD+K +N+L+ G VKL DFGVS Q+ +IA K+++GT +MAPE + E+ G +
Sbjct: 132 KMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGY 191
Query: 337 S---DVWSLGISFMEIQKNQGSLMPLQLLQCIV------DEDSPVLPVGEFSEPFVHFIT 387
+ D+W++GI+ +E+ + Q + L ++ + + + ++S F HF+
Sbjct: 192 NQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVK 251
Query: 388 QCMRKQPKERPAPEELMGHPFIVQ 411
+ K PK+RP E+L+ HPF+ Q
Sbjct: 252 MALTKNPKKRPTAEKLLQHPFVTQ 275
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 140 bits (352), Expect = 3e-33
Identities = 90/263 (34%), Positives = 147/263 (55%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I +P L ++S+ F FI
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K +RPA E+LM HPFI
Sbjct: 267 ESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 140 bits (352), Expect = 3e-33
Identities = 90/263 (34%), Positives = 147/263 (55%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I +P L ++S+ F FI
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K +RPA E+LM HPFI
Sbjct: 267 ESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 140 bits (352), Expect = 3e-33
Identities = 90/263 (34%), Positives = 147/263 (55%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I +P L ++S+ F FI
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K +RPA E+LM HPFI
Sbjct: 267 ESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 140 bits (352), Expect = 3e-33
Identities = 90/263 (34%), Positives = 147/263 (55%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I +P L ++S+ F FI
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K +RPA E+LM HPFI
Sbjct: 267 ESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 140 bits (352), Expect = 3e-33
Identities = 90/263 (34%), Positives = 147/263 (55%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I +P L ++S+ F FI
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K +RPA E+LM HPFI
Sbjct: 267 ESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 140 bits (352), Expect = 3e-33
Identities = 90/263 (34%), Positives = 147/263 (55%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I +P L ++S+ F FI
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K +RPA E+LM HPFI
Sbjct: 267 ESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 140 bits (352), Expect = 3e-33
Identities = 90/263 (34%), Positives = 147/263 (55%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I +P L ++S+ F FI
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K +RPA E+LM HPFI
Sbjct: 267 ESCLVKNHSQRPATEQLMKHPFI 289
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 140 bits (352), Expect = 3e-33
Identities = 90/263 (34%), Positives = 147/263 (55%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 ELVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTGDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFVEN------RISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF +N ++ + EF GS+ K + E + I +++GL++L
Sbjct: 87 GAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I +P L ++S+ F FI
Sbjct: 207 DATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K +RPA E+LM HPFI
Sbjct: 267 ESCLVKNHSQRPATEQLMKHPFI 289
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 138 bits (348), Expect = 9e-33
Identities = 87/262 (33%), Positives = 142/262 (54%), Gaps = 17/262 (6%)
Query: 172 LGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAF 231
LG G G VYKA + +G + A KVI EL+ I+ E+EIL CD YI+ GA+
Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIV-EIEILATCDHPYIVKLLGAY 100
Query: 232 FVENRISICTEFMDGGSLDVY-----RKMPEHVLGRIAVAVVKGLTYLWSLKILHRDVKP 286
+ + ++ I EF GG++D R + E + + +++ L +L S +I+HRD+K
Sbjct: 101 YHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKA 160
Query: 287 SNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGE-----QYGIHSDV 339
N+L+ G ++L DFGVS + + ++ K +++GT +MAPE + E Y +D+
Sbjct: 161 GNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADI 220
Query: 340 WSLGISFME---IQKNQGSLMPLQLLQCIVDEDSP-VLPVGEFSEPFVHFITQCMRKQPK 395
WSLGI+ +E I+ L P+++L I D P +L ++S F F+ + K P+
Sbjct: 221 WSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPE 280
Query: 396 ERPAPEELMGHPFIVQFNDGNA 417
RP+ +L+ HPF+ A
Sbjct: 281 TRPSAAQLLEHPFVSSITSNKA 302
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 137 bits (346), Expect = 1e-32
Identities = 84/255 (32%), Positives = 144/255 (56%), Gaps = 16/255 (6%)
Query: 172 LGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAF 231
+G G G VYKA + ++ AVK++ LD ++ + E+ IL +C ++ + G++
Sbjct: 22 VGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISS-LQQEITILRECRHPNVVAYIGSY 80
Query: 232 FVENRISICTEFMDGGSL-DVYRK---MPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPS 287
+R+ IC EF GGSL ++Y + E + + +KGL +L S +HRD+K +
Sbjct: 81 LRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGA 140
Query: 288 NMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQYGIHS---DVWSL 342
N+L+ +G VKL DFGVS +L S+AK +++GT +MAPE + E+ G ++ DVW+L
Sbjct: 141 NLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWAL 200
Query: 343 GISFMEIQKNQGSLMPLQLLQCIV------DEDSPVLPVGEFSEPFVHFITQCMRKQPKE 396
GI+ +E+ + Q L L ++ ++ + + +++ F HF+ + K PK+
Sbjct: 201 GITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKK 260
Query: 397 RPAPEELMGHPFIVQ 411
RP E+L+ HPF Q
Sbjct: 261 RPTAEKLLQHPFTTQ 275
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 132 bits (332), Expect = 6e-31
Identities = 86/263 (32%), Positives = 144/263 (54%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFV------ENRISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF ++++ + EF GS+ K + E + I +++GL +L +
Sbjct: 87 GAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHA 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I P L ++S+ F+ FI
Sbjct: 207 DATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K RP E+L+ PFI
Sbjct: 267 DTCLIKTYLSRPPTEQLLKFPFI 289
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 132 bits (332), Expect = 6e-31
Identities = 86/263 (32%), Positives = 144/263 (54%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFV------ENRISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF ++++ + EF GS+ K + E + I +++GL +L +
Sbjct: 87 GAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHA 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I P L ++S+ F+ FI
Sbjct: 207 DATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K RP E+L+ PFI
Sbjct: 267 DTCLIKTYLSRPPTEQLLKFPFI 289
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 132 bits (332), Expect = 6e-31
Identities = 86/263 (32%), Positives = 144/263 (54%), Gaps = 25/263 (9%)
Query: 170 DTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIG-FY 228
+ +G+G G VYK HV +G++ A+KV +D+T + +++I E+ +L K I +Y
Sbjct: 29 EVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVTEDEEEEIKQEINMLKKYSHHRNIATYY 86
Query: 229 GAFFV------ENRISICTEFMDGGSLDVYRK------MPEHVLGRIAVAVVKGLTYLWS 276
GAF ++++ + EF GS+ K + E + I +++GL +L +
Sbjct: 87 GAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHA 146
Query: 277 LKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERISGEQ-- 332
K++HRD+K N+L+ +VKL DFGVS QL ++ + T++GT +MAPE I+ ++
Sbjct: 147 HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENP 206
Query: 333 ---YGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEFSEPFVHFI 386
Y SD+WSLGI+ +E+ + L P++ L I P L ++S+ F+ FI
Sbjct: 207 DATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFI 266
Query: 387 TQCMRKQPKERPAPEELMGHPFI 409
C+ K RP E+L+ PFI
Sbjct: 267 DTCLIKTYLSRPPTEQLLKFPFI 289
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,782,303
Number of Sequences: 37866
Number of extensions: 809402
Number of successful extensions: 3823
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 684
Number of HSP's successfully gapped in prelim test: 109
Number of HSP's that attempted gapping in prelim test: 1744
Number of HSP's gapped (non-prelim): 927
length of query: 438
length of database: 18,247,518
effective HSP length: 105
effective length of query: 333
effective length of database: 14,271,588
effective search space: 4752438804
effective search space used: 4752438804
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.