Search of human proteins with 4505863

Search of human proteins with 4505863

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505863 plasminogen activator, urokinase isoform 1
preproprotein [Homo sapiens]
         (431 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505863 plasminogen activator, urokinase isoform 1 preproprot...   926   0.0  
gi|222537759 plasminogen activator, urokinase isoform 2 [Homo sa...   873   0.0  
gi|4505861 plasminogen activator, tissue isoform 1 preproprotein...   300   1e-81
gi|14702169 plasminogen activator, tissue isoform 3 preproprotei...   300   1e-81
gi|4504383 HGF activator preproprotein [Homo sapiens]                 277   1e-74
gi|145275213 coagulation factor XII precursor [Homo sapiens]          254   1e-67
gi|4758502 hyaluronan binding protein 2 preproprotein [Homo sapi...   246   2e-65
gi|4505881 plasminogen [Homo sapiens]                                 181   1e-45
gi|4506143 neurotrypsin precursor [Homo sapiens]                      171   1e-42
gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]               169   3e-42
gi|117956391 protease, serine, 33 [Homo sapiens]                      167   2e-41
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          162   7e-40
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         159   6e-39
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           154   1e-37
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             153   3e-37
gi|4506153 prostasin preproprotein [Homo sapiens]                     152   4e-37
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           152   4e-37
gi|11496281 kallikrein 13 precursor [Homo sapiens]                    152   7e-37
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          149   5e-36
gi|33695155 hepsin [Homo sapiens]                                     145   5e-35
gi|61744424 kallikrein-related peptidase 6 isoform A preproprote...   145   5e-35
gi|4506155 kallikrein-related peptidase 6 isoform A preproprotei...   145   5e-35
gi|4504481 hepsin [Homo sapiens]                                      145   5e-35
gi|205277383 macrophage stimulating 1 (hepatocyte growth factor-...   144   1e-34
gi|118498341 chymotrypsin B1 [Homo sapiens]                           142   4e-34
gi|4503137 chymotrypsin-like [Homo sapiens]                           142   6e-34
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]           142   8e-34
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]       142   8e-34
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]        142   8e-34
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]      142   8e-34

>gi|4505863 plasminogen activator, urokinase isoform 1 preproprotein
           [Homo sapiens]
          Length = 431

 Score =  926 bits (2394), Expect = 0.0
 Identities = 431/431 (100%), Positives = 431/431 (100%)

Query: 1   MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ 60
           MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
Sbjct: 1   MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ 60

Query: 61  HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN 120
           HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
Sbjct: 61  HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN 120

Query: 121 YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII 180
           YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
Sbjct: 121 YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII 180

Query: 181 GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG 240
           GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
Sbjct: 181 GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG 240

Query: 241 RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL 300
           RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
Sbjct: 241 RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL 300

Query: 301 PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML 360
           PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
Sbjct: 301 PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML 360

Query: 361 CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR 420
           CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
Sbjct: 361 CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR 420

Query: 421 SHTKEENGLAL 431
           SHTKEENGLAL
Sbjct: 421 SHTKEENGLAL 431


>gi|222537759 plasminogen activator, urokinase isoform 2 [Homo
           sapiens]
          Length = 414

 Score =  873 bits (2255), Expect = 0.0
 Identities = 402/403 (99%), Positives = 403/403 (100%)

Query: 29  SNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMG 88
           +NCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMG
Sbjct: 12  ANCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMG 71

Query: 89  RPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMV 148
           RPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMV
Sbjct: 72  RPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMV 131

Query: 149 HDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYV 208
           HDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYV
Sbjct: 132 HDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYV 191

Query: 209 CGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSAD 268
           CGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSAD
Sbjct: 192 CGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSAD 251

Query: 269 TLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLY 328
           TLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLY
Sbjct: 252 TLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLY 311

Query: 329 PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRM 388
           PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRM
Sbjct: 312 PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRM 371

Query: 389 TLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL 431
           TLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
Sbjct: 372 TLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL 414


>gi|4505861 plasminogen activator, tissue isoform 1 preproprotein
           [Homo sapiens]
          Length = 562

 Score =  300 bits (769), Expect = 1e-81
 Identities = 163/389 (41%), Positives = 214/389 (55%), Gaps = 30/389 (7%)

Query: 50  WCNCPK--KFGGQHCEI----DKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQT 103
           WC   K  K+  + C      + +  CY GNG  YRG  S    G  CLPWNS  ++ + 
Sbjct: 189 WCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKV 248

Query: 104 YHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEE 163
           Y A    A  LGLGKHNYCRNPD   +PWC+V    +   + C V  C+           
Sbjct: 249 YTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCS----------- 297

Query: 164 LKFQCG-QKTLRPRFKIIGGEFTTIENQPWFAAIYRRH-RGGSVTYVCGGSLISPCWVIS 221
               CG ++  +P+F+I GG F  I + PW AAI+ +H R     ++CGG LIS CW++S
Sbjct: 298 ---TCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILS 354

Query: 222 ATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI 281
           A HCF +        V LGR+      + E KFEVE  I+HK++  DT  + NDIALL++
Sbjct: 355 AAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDT--YDNDIALLQL 412

Query: 282 RSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLIS 341
           +S   RCAQ S  ++T+CLP         T CE++G+GK  +    Y E+LK   V+L  
Sbjct: 413 KSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYP 472

Query: 342 HRECQQPHYYGSEVTTKMLCAAD-----PQWKT-DSCQGDSGGPLVCSLQGRMTLTGIVS 395
              C   H     VT  MLCA D     PQ    D+CQGDSGGPLVC   GRMTL GI+S
Sbjct: 473 SSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIIS 532

Query: 396 WGRGCALKDKPGVYTRVSHFLPWIRSHTK 424
           WG GC  KD PGVYT+V+++L WIR + +
Sbjct: 533 WGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561



 Score =  130 bits (327), Expect = 2e-30
 Identities = 64/141 (45%), Positives = 78/141 (55%), Gaps = 5/141 (3%)

Query: 18  SKGSNELHQVP----SNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEG 73
           + G  + H VP    S   C NGGTC    YFS+   C CP+ F G+ CEID   TCYE 
Sbjct: 72  NSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFV-CQCPEGFAGKCCEIDTRATCYED 130

Query: 74  NGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWC 133
            G  YRG  ST   G  C  WNS+ + Q+ Y   R DA++LGLG HNYCRNPD   +PWC
Sbjct: 131 QGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWC 190

Query: 134 YVQVGLKPLVQECMVHDCADG 154
           YV    K   + C    C++G
Sbjct: 191 YVFKAGKYSSEFCSTPACSEG 211


>gi|14702169 plasminogen activator, tissue isoform 3 preproprotein
           [Homo sapiens]
          Length = 516

 Score =  300 bits (769), Expect = 1e-81
 Identities = 163/389 (41%), Positives = 214/389 (55%), Gaps = 30/389 (7%)

Query: 50  WCNCPK--KFGGQHCEI----DKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQT 103
           WC   K  K+  + C      + +  CY GNG  YRG  S    G  CLPWNS  ++ + 
Sbjct: 143 WCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKV 202

Query: 104 YHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEE 163
           Y A    A  LGLGKHNYCRNPD   +PWC+V    +   + C V  C+           
Sbjct: 203 YTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCS----------- 251

Query: 164 LKFQCG-QKTLRPRFKIIGGEFTTIENQPWFAAIYRRH-RGGSVTYVCGGSLISPCWVIS 221
               CG ++  +P+F+I GG F  I + PW AAI+ +H R     ++CGG LIS CW++S
Sbjct: 252 ---TCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILS 308

Query: 222 ATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI 281
           A HCF +        V LGR+      + E KFEVE  I+HK++  DT  + NDIALL++
Sbjct: 309 AAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDT--YDNDIALLQL 366

Query: 282 RSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLIS 341
           +S   RCAQ S  ++T+CLP         T CE++G+GK  +    Y E+LK   V+L  
Sbjct: 367 KSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYP 426

Query: 342 HRECQQPHYYGSEVTTKMLCAAD-----PQWKT-DSCQGDSGGPLVCSLQGRMTLTGIVS 395
              C   H     VT  MLCA D     PQ    D+CQGDSGGPLVC   GRMTL GI+S
Sbjct: 427 SSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIIS 486

Query: 396 WGRGCALKDKPGVYTRVSHFLPWIRSHTK 424
           WG GC  KD PGVYT+V+++L WIR + +
Sbjct: 487 WGLGCGQKDVPGVYTKVTNYLDWIRDNMR 515



 Score =  129 bits (324), Expect = 5e-30
 Identities = 71/163 (43%), Positives = 84/163 (51%), Gaps = 13/163 (7%)

Query: 2   RALLARLLLCVLVVSDSKGSNELH----------QVPSNCDCLNGGTCVSNKYFSNIHWC 51
           R L   LLLC  V      S E+H          Q  S   C NGGTC    YFS+   C
Sbjct: 6   RGLCCVLLLCGAVFVSP--SQEIHARFRRGARSYQGCSEPRCFNGGTCQQALYFSDFV-C 62

Query: 52  NCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDA 111
            CP+ F G+ CEID   TCYE  G  YRG  ST   G  C  WNS+ + Q+ Y   R DA
Sbjct: 63  QCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDA 122

Query: 112 LQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADG 154
           ++LGLG HNYCRNPD   +PWCYV    K   + C    C++G
Sbjct: 123 IRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEG 165


>gi|4504383 HGF activator preproprotein [Homo sapiens]
          Length = 655

 Score =  277 bits (709), Expect = 1e-74
 Identities = 159/418 (38%), Positives = 213/418 (50%), Gaps = 31/418 (7%)

Query: 25  HQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKAST 84
           H    +  CLNGGTC      +    C CP  F G+ C I+  + C+ GNG  YRG AST
Sbjct: 242 HTACLSSPCLNGGTC-HLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVAST 300

Query: 85  DTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQ 144
              G  CL WNS  + Q+ +      A  LGLG H YCRNPDN  RPWCYV        +
Sbjct: 301 SASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWE 360

Query: 145 ECMVHDC-------------ADGKKPSSPPEELKFQCGQKT-----LRPRFKIIGGEFTT 186
            C +  C             A   +P+SP  +    CG++      LRPR  IIGG  + 
Sbjct: 361 YCRLEACESLTRVQLSPDLLATLPEPASPGRQA---CGRRHKKRTFLRPR--IIGGSSSL 415

Query: 187 IENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNS 246
             + PW AAIY    G S    C GSL+  CWV+SA HCF   P ++   V LG+   N 
Sbjct: 416 PGSHPWLAAIYI---GDSF---CAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNR 469

Query: 247 NTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYND 306
            T     F +E  I +  YS    + H D+ L++++ K  RCA  S+ +Q ICLP   + 
Sbjct: 470 TTDVTQTFGIEKYIPYTLYSVFNPSDH-DLVLIRLKKKGDRCATRSQFVQPICLPEPGST 528

Query: 307 PQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQ 366
              G  C+I G+G  +     Y   L+  +V L++  +C  P  YG++++  MLCA    
Sbjct: 529 FPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFD 588

Query: 367 WKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK 424
            K+D+CQGDSGGPL C   G   L GI+SWG GC    KPGVYTRV++++ WI    +
Sbjct: 589 CKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIR 646



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 18/42 (42%), Positives = 25/42 (59%), Gaps = 3/42 (7%)

Query: 33  CLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDK--SKTCYE 72
           CLNGG+C SN      + C+CP+ F G+ C  +K   +T YE
Sbjct: 169 CLNGGSC-SNTQDPQSYHCSCPRAFTGKDCGTEKCFDETRYE 209


>gi|145275213 coagulation factor XII precursor [Homo sapiens]
          Length = 615

 Score =  254 bits (648), Expect = 1e-67
 Identities = 153/446 (34%), Positives = 213/446 (47%), Gaps = 70/446 (15%)

Query: 33  CLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCL 92
           CL+GG C+          C+CP  + G  C++D   +CY+G G  YRG A T   G PC 
Sbjct: 183 CLHGGRCLE---VEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQ 239

Query: 93  PWNSATVLQQTY-HAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDC 151
           PW S    + TY +     A   GLG H +CRNPDN  RPWC+V    +   + C +  C
Sbjct: 240 PWAS----EATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQC 295

Query: 152 -----------------------------------------------ADGKKPSSPPEEL 164
                                                          A  ++P S     
Sbjct: 296 QTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNG 355

Query: 165 KFQCGQ---KTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVIS 221
              CGQ   K+L    +++GG        P+ AA+Y  H        C GSLI+PCWV++
Sbjct: 356 PLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHS------FCAGSLIAPCWVLT 409

Query: 222 ATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI 281
           A HC  D P  ED  V LG+ R N + +      V +  LH+ +S   +++ +D+ALL++
Sbjct: 410 AAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSP--VSYQHDLALLRL 467

Query: 282 RSK-EGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLI 340
           +   +G CA  S  +Q +CLPS    P   T C++ G+G +      Y   L+   V  +
Sbjct: 468 QEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFL 527

Query: 341 SHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQG---RMTLTGIVSWG 397
           S   C  P  +GS +   MLCA   +  TD+CQGDSGGPLVC  Q    R+TL GI+SWG
Sbjct: 528 SLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWG 587

Query: 398 RGCALKDKPGVYTRVSHFLPWIRSHT 423
            GC  ++KPGVYT V+++L WIR HT
Sbjct: 588 SGCGDRNKPGVYTDVAYYLAWIREHT 613



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 6/40 (15%)

Query: 33  CLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYE 72
           C  GGTCV+    S  H C CP+   G HC+ +K   C+E
Sbjct: 104 CQKGGTCVNMP--SGPH-CLCPQHLTGNHCQKEK---CFE 137


>gi|4758502 hyaluronan binding protein 2 preproprotein [Homo
           sapiens]
          Length = 560

 Score =  246 bits (629), Expect = 2e-65
 Identities = 153/413 (37%), Positives = 210/413 (50%), Gaps = 29/413 (7%)

Query: 33  CLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCL 92
           C NG TC  +K  S    C CP +F G+ CEI  S  CY G+G+ YRGK +       CL
Sbjct: 159 CQNGATCSRHKRRSKFT-CACPDQFKGKFCEIG-SDDCYVGDGYSYRGKMNRTVNQHACL 216

Query: 93  PWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPL------VQEC 146
            WNS  +LQ+ Y+    DA   G+G+HN+CRNPD   +PWC+++V    +      V  C
Sbjct: 217 YWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSAC 276

Query: 147 MVHDCA-DGKKPSSPPEELK--FQCGQKTLRPR--FKIIGGEFTTIENQPWFAAIYRR-- 199
              D A   + P+ P  +L     CG+  +  R   +I GG  +T    PW A++     
Sbjct: 277 SAQDVAYPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLP 336

Query: 200 -HRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVEN 258
                   + CGG+LI PCWV++A HC     K     V LG   L      E  F VE 
Sbjct: 337 LTISMPQGHFCGGALIHPCWVLTAAHC--TDIKTRHLKVVLGDQDLKKEEFHEQSFRVEK 394

Query: 259 LILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQF--GTSCEIT 316
           +  +  Y+      HNDIALLK++  +G CA  S+ ++T+CLP    D  F  G+ C I+
Sbjct: 395 IFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLP----DGSFPSGSECHIS 450

Query: 317 GFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWK-TDSCQGD 375
           G+G   +       QL    VKLI++  C     Y   +   M+CA + Q    D+CQGD
Sbjct: 451 GWGVTETGK--GSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGD 508

Query: 376 SGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENG 428
           SGGPL C   G   + GIVSWG  C    +PGVYT+V+ FL WI++  K E+G
Sbjct: 509 SGGPLTCEKDGTYYVYGIVSWGLECG--KRPGVYTQVTKFLNWIKATIKSESG 559


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  181 bits (458), Expect = 1e-45
 Identities = 127/361 (35%), Positives = 170/361 (47%), Gaps = 35/361 (9%)

Query: 63  EIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYC 122
           E    + C  GNG  YRGK +T   G PC  W +    + +     ++  + GL K NYC
Sbjct: 474 ETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNP-RAGLEK-NYC 531

Query: 123 RNPDNR-RRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRF---K 178
           RNPD     PWCY     + L   C V  CA    PS       F CG+  + P+    +
Sbjct: 532 RNPDGDVGGPWCYT-TNPRKLYDYCDVPQCA---APS-------FDCGKPQVEPKKCPGR 580

Query: 179 IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVY 238
           ++GG      + PW  ++  R R G   + CGG+LISP WV++A HC    P+   Y V 
Sbjct: 581 VVGGCVAHPHSWPWQVSL--RTRFGM--HFCGGTLISPEWVLTAAHCLEKSPRPSSYKVI 636

Query: 239 LGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTI 298
           LG  +  +      + EV  L L             DIALLK+ S     A  +  +   
Sbjct: 637 LGAHQEVNLEPHVQEIEVSRLFLEPT--------RKDIALLKLSSP----AVITDKVIPA 684

Query: 299 CLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTK 358
           CLPS        T C ITG+G+   T       LK   + +I ++ C +  +    V + 
Sbjct: 685 CLPSPNYVVADRTECFITGWGETQGT--FGAGLLKEAQLPVIENKVCNRYEFLNGRVQST 742

Query: 359 MLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPW 418
            LCA      TDSCQGDSGGPLVC  + +  L G+ SWG GCA  +KPGVY RVS F+ W
Sbjct: 743 ELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTW 802

Query: 419 I 419
           I
Sbjct: 803 I 803



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 28/67 (41%), Positives = 38/67 (56%), Gaps = 7/67 (10%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATV--LQQTYHAHRSDALQLGLGKHNYCRNPDN 127
           CY G+G  YRG +ST T G+ C  W+S T    Q+T   + +  L +     NYCRNPD 
Sbjct: 377 CYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTM-----NYCRNPDA 431

Query: 128 RRRPWCY 134
            + PWC+
Sbjct: 432 DKGPWCF 438



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 30/101 (29%), Positives = 42/101 (41%), Gaps = 14/101 (13%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGK--HNYCRNPDN 127
           C +G G  YRG  +    G  C  W++     QT H H              NYCRNPD 
Sbjct: 275 CLKGTGENYRGNVAVTVSGHTCQHWSA-----QTPHTHNRTPENFPCKNLDENYCRNPDG 329

Query: 128 RRRPWCYVQVGLKPLVQECMVHDC------ADGKKPSSPPE 162
           +R PWC+     +   + C +  C       +   P++PPE
Sbjct: 330 KRAPWCHT-TNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPE 369



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 27/68 (39%), Positives = 34/68 (50%), Gaps = 8/68 (11%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYH--AHRSDALQLGLGKHNYCRNPDN 127
           C  GNG  YRG  S    G  C  W+S +  +  +    H S+ L+      NYCRNPDN
Sbjct: 103 CKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLE-----ENYCRNPDN 157

Query: 128 -RRRPWCY 134
             + PWCY
Sbjct: 158 DPQGPWCY 165



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 26/75 (34%), Positives = 35/75 (46%), Gaps = 4/75 (5%)

Query: 61  HCEI-DKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKH 119
           +C+I +  + C   +G  Y GK S    G  C  W+S +     Y   +     L   K 
Sbjct: 175 YCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNL---KK 231

Query: 120 NYCRNPDNRRRPWCY 134
           NYCRNPD   RPWC+
Sbjct: 232 NYCRNPDRELRPWCF 246


>gi|4506143 neurotrypsin precursor [Homo sapiens]
          Length = 875

 Score =  171 bits (433), Expect = 1e-42
 Identities = 104/279 (37%), Positives = 150/279 (53%), Gaps = 15/279 (5%)

Query: 154 GKKPS--SPPEELKFQCGQKTLRPRFK-IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCG 210
           GKK S  S  E L   CG + L  R K IIGG+ +     PW  ++  +   G    +CG
Sbjct: 603 GKKASGNSNKESLSSVCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCG 662

Query: 211 GSLISPCWVISATHCFIDYPKK-EDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADT 269
            +L+S CWV++A HCF  Y      Y V +G        + E +  V+ +++H++Y  D 
Sbjct: 663 ATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDR 722

Query: 270 LAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQ-FGTSCEITGFGKENSTDYLY 328
             +  DIAL++++  E +CA+ S  +   CLP     PQ   ++C ITG+G    T   Y
Sbjct: 723 SDY--DIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWG---DTGRAY 777

Query: 329 PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAAD--PQWKTDSCQGDSGGPLVCSLQG 386
              L+   + L+  R C++   Y    T +MLCA +     + DSCQGDSGGPL+C   G
Sbjct: 778 SRTLQQAAIPLLPKRFCEER--YKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPG 835

Query: 387 RMTLT-GIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK 424
              +  G+ SWG GC +KD PGVYT+VS F+PWI+S TK
Sbjct: 836 ESWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTK 874



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 83  STDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCY 134
           S    G PCL W  A V      +  +   QL   +HN+CR+PD   RPWC+
Sbjct: 101 SVTDFGAPCLRW--AEVPPFLERSPPASWAQLRGQRHNFCRSPDGAGRPWCF 150


>gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]
          Length = 2040

 Score =  169 bits (429), Expect = 3e-42
 Identities = 125/359 (34%), Positives = 160/359 (44%), Gaps = 54/359 (15%)

Query: 70   CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGK-----HNYCRN 124
            C  GNG  YRGK +T   G PC  W +          HR      G  K      NYCRN
Sbjct: 1720 CMFGNGKGYRGKKATTVTGTPCQEWAAQ-------EPHRHSTFIPGTNKWAGLEKNYCRN 1772

Query: 125  PDNR-RRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRF---KII 180
            PD     PWCY  +  + L   C +  CA             F CG+  + P+     I+
Sbjct: 1773 PDGDINGPWCYT-MNPRKLFDYCDIPLCASSS----------FDCGKPQVEPKKCPGSIV 1821

Query: 181  GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG 240
            GG      + PW  ++  R R G   + CGG+LISP WV++A HC     +   Y V LG
Sbjct: 1822 GGCVAHPHSWPWQVSL--RTRFGK--HFCGGTLISPEWVLTAAHCLKKSSRPSSYKVILG 1877

Query: 241  RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL 300
              +  +      + EV  L L    +        DIALLK+     R A  +  +   CL
Sbjct: 1878 AHQEVNLESHVQEIEVSRLFLEPTQA--------DIALLKL----SRPAVITDKVMPACL 1925

Query: 301  PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML 360
            PS        T C ITG+G+   T       LK   + +I +  C   HY       K +
Sbjct: 1926 PSPDYMVTARTECYITGWGETQGT--FGTGLLKEAQLLVIENEVCN--HY-------KYI 1974

Query: 361  CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWI 419
            CA      TDSCQGDSGGPLVC  + +  L G+ SWG GCA  +KPGVY RVS F+ WI
Sbjct: 1975 CAEHLARGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWI 2033



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 29/65 (44%), Positives = 34/65 (52%), Gaps = 3/65 (4%)

Query: 70   CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRR 129
            CY G+G  YRG  ST   GR C  W+S T     +H   ++    G    NYCRNPD   
Sbjct: 1274 CYHGDGQSYRGSFSTTVTGRTCQSWSSMT---PHWHQRTTEYYPNGGLTRNYCRNPDAEI 1330

Query: 130  RPWCY 134
            RPWCY
Sbjct: 1331 RPWCY 1335



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 33/68 (48%), Positives = 36/68 (52%), Gaps = 9/68 (13%)

Query: 70   CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDAL---QLGLGKHNYCRNPD 126
            CY G+G  YRG  ST   GR C  W+S      T H HR   L     GL + NYCRNPD
Sbjct: 1388 CYRGDGQSYRGTLSTTITGRTCQSWSS-----MTPHWHRRIPLYYPNAGLTR-NYCRNPD 1441

Query: 127  NRRRPWCY 134
               RPWCY
Sbjct: 1442 AEIRPWCY 1449



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 34/90 (37%), Positives = 46/90 (51%), Gaps = 12/90 (13%)

Query: 68   KTCYEGNGHFYRGKASTDTMGRPCLPWNSATV--LQQTYHAHRSDALQLGLGKHNYCRNP 125
            + CY GNG  YRG  ST   GR C  W+S T    Q+T   + +D L +     NYCRNP
Sbjct: 1614 RQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTM-----NYCRNP 1668

Query: 126  DNRRRPWCYVQVGLKPLV--QECMVHDCAD 153
            D    PWC+    + P +  + C +  C+D
Sbjct: 1669 DADTGPWCFT---MDPSIRWEYCNLTRCSD 1695



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 28/65 (43%), Positives = 33/65 (50%), Gaps = 3/65 (4%)

Query: 70   CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRR 129
            CY G+G  YRG  ST   GR C  W+S T     +H   ++    G    NYCRNPD   
Sbjct: 1168 CYHGDGQSYRGSFSTTVTGRTCQSWSSMT---PHWHQRTTEYYPNGGLTRNYCRNPDAEI 1224

Query: 130  RPWCY 134
             PWCY
Sbjct: 1225 SPWCY 1229



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 27/65 (41%), Positives = 37/65 (56%), Gaps = 3/65 (4%)

Query: 70   CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRR 129
            CY G+G  YRG +ST   GR C  W+S  ++   +     +    GL   NYCRNPD+ +
Sbjct: 1502 CYHGDGRSYRGISSTTVTGRTCQSWSS--MIPHWHQRTPENYPNAGL-TENYCRNPDSGK 1558

Query: 130  RPWCY 134
            +PWCY
Sbjct: 1559 QPWCY 1563



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 36/96 (37%), Positives = 46/96 (47%), Gaps = 12/96 (12%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAH-RSDALQLGLGK-HNYCRNPDN 127
           CY GNG  YRG  ST   GR C  W+S      T H+H R+       G   NYCRNPD 
Sbjct: 826 CYHGNGQSYRGTYSTTVTGRTCQAWSS-----MTPHSHSRTPEYYPNAGLIMNYCRNPDP 880

Query: 128 RRRPWCYVQVGLKPLV--QECMVHDCADGKKPSSPP 161
              P+CY +    P V  + C +  C+D +  +  P
Sbjct: 881 VAAPYCYTR---DPSVRWEYCNLTQCSDAEGTAVAP 913



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/95 (36%), Positives = 47/95 (49%), Gaps = 10/95 (10%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAH-RSDALQLGLGK-HNYCRNPDN 127
           CY GNG  YRG  ST   GR C  W+S      T H+H R+       G   NYCRNPD 
Sbjct: 142 CYHGNGQSYRGTYSTTVTGRTCQAWSS-----MTPHSHSRTPEYYPNAGLIMNYCRNPDA 196

Query: 128 RRRPWCYVQ-VGLKPLVQECMVHDCADGKKPSSPP 161
              P+CY +  G++   + C +  C+D +  +  P
Sbjct: 197 VAAPYCYTRDPGVR--WEYCNLTQCSDAEGTAVAP 229



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/95 (36%), Positives = 47/95 (49%), Gaps = 10/95 (10%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAH-RSDALQLGLGK-HNYCRNPDN 127
           CY GNG  YRG  ST   GR C  W+S      T H+H R+       G   NYCRNPD 
Sbjct: 256 CYHGNGQSYRGTYSTTVTGRTCQAWSS-----MTPHSHSRTPEYYPNAGLIMNYCRNPDA 310

Query: 128 RRRPWCYVQ-VGLKPLVQECMVHDCADGKKPSSPP 161
              P+CY +  G++   + C +  C+D +  +  P
Sbjct: 311 VAAPYCYTRDPGVR--WEYCNLTQCSDAEGTAVAP 343



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/95 (36%), Positives = 47/95 (49%), Gaps = 10/95 (10%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAH-RSDALQLGLGK-HNYCRNPDN 127
           CY GNG  YRG  ST   GR C  W+S      T H+H R+       G   NYCRNPD 
Sbjct: 370 CYHGNGQSYRGTYSTTVTGRTCQAWSS-----MTPHSHSRTPEYYPNAGLIMNYCRNPDA 424

Query: 128 RRRPWCYVQ-VGLKPLVQECMVHDCADGKKPSSPP 161
              P+CY +  G++   + C +  C+D +  +  P
Sbjct: 425 VAAPYCYTRDPGVR--WEYCNLTQCSDAEGTAVAP 457



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/95 (36%), Positives = 47/95 (49%), Gaps = 10/95 (10%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAH-RSDALQLGLGK-HNYCRNPDN 127
           CY GNG  YRG  ST   GR C  W+S      T H+H R+       G   NYCRNPD 
Sbjct: 484 CYHGNGQSYRGTYSTTVTGRTCQAWSS-----MTPHSHSRTPEYYPNAGLIMNYCRNPDA 538

Query: 128 RRRPWCYVQ-VGLKPLVQECMVHDCADGKKPSSPP 161
              P+CY +  G++   + C +  C+D +  +  P
Sbjct: 539 VAAPYCYTRDPGVR--WEYCNLTQCSDAEGTAVAP 571



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/95 (36%), Positives = 47/95 (49%), Gaps = 10/95 (10%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAH-RSDALQLGLGK-HNYCRNPDN 127
           CY GNG  YRG  ST   GR C  W+S      T H+H R+       G   NYCRNPD 
Sbjct: 598 CYHGNGQSYRGTYSTTVTGRTCQAWSS-----MTPHSHSRTPEYYPNAGLIMNYCRNPDA 652

Query: 128 RRRPWCYVQ-VGLKPLVQECMVHDCADGKKPSSPP 161
              P+CY +  G++   + C +  C+D +  +  P
Sbjct: 653 VAAPYCYTRDPGVR--WEYCNLTQCSDAEGTAVAP 685



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 35/95 (36%), Positives = 47/95 (49%), Gaps = 10/95 (10%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAH-RSDALQLGLGK-HNYCRNPDN 127
           CY GNG  YRG  ST   GR C  W+S      T H+H R+       G   NYCRNPD 
Sbjct: 712 CYHGNGQSYRGTYSTTVTGRTCQAWSS-----MTPHSHSRTPEYYPNAGLIMNYCRNPDA 766

Query: 128 RRRPWCYVQ-VGLKPLVQECMVHDCADGKKPSSPP 161
              P+CY +  G++   + C +  C+D +  +  P
Sbjct: 767 VAAPYCYTRDPGVR--WEYCNLTQCSDAEGTAVAP 799



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 28/65 (43%), Positives = 31/65 (47%), Gaps = 3/65 (4%)

Query: 70   CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRR 129
            CY   G  YRG  ST   GR C  W+S T  Q   H+   +         NYCRNPD   
Sbjct: 1054 CYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQ---HSRTPENYPNAGLTRNYCRNPDAEI 1110

Query: 130  RPWCY 134
            RPWCY
Sbjct: 1111 RPWCY 1115



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 32/93 (34%), Positives = 44/93 (47%), Gaps = 6/93 (6%)

Query: 70  CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRR 129
           CY G+G  YRG  ST   GR C  W+S T  Q            L +   NYCRNPD   
Sbjct: 28  CYHGDGQSYRGTYSTTVTGRTCQAWSSMTPHQHNRTTENYPNAGLIM---NYCRNPDAVA 84

Query: 130 RPWCYVQ-VGLKPLVQECMVHDCADGKKPSSPP 161
            P+CY +  G++   + C +  C+D +  +  P
Sbjct: 85  APYCYTRDPGVR--WEYCNLTQCSDAEGTAVAP 115



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 34/90 (37%), Positives = 42/90 (46%), Gaps = 12/90 (13%)

Query: 70   CYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAH-RSDALQLGLGK-HNYCRNPDN 127
            CY GNG  Y+G       GR C  W+S      T H+H R+ A     G   NYCRNPD 
Sbjct: 940  CYHGNGQSYQGTYFITVTGRTCQAWSS-----MTPHSHSRTPAYYPNAGLIKNYCRNPDP 994

Query: 128  RRRPWCYVQVGLKPLV--QECMVHDCADGK 155
               PWCY      P V  + C +  C+D +
Sbjct: 995  VAAPWCYT---TDPSVRWEYCNLTRCSDAE 1021


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  167 bits (423), Expect = 2e-41
 Identities = 105/263 (39%), Positives = 140/263 (53%), Gaps = 23/263 (8%)

Query: 168 CGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFI 227
           CGQ  +  R  I+GG        PW A+I  +HRG    +VCGGSLI+P WV++A HCF 
Sbjct: 28  CGQPRMSSR--IVGGRDGRDGEWPWQASI--QHRGA---HVCGGSLIAPQWVLTAAHCFP 80

Query: 228 DYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGR 287
                 +Y V LG  RL S +   +   V  ++L  DYS D      D+ALL++R    R
Sbjct: 81  RRALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSED--GARGDLALLQLR----R 134

Query: 288 CAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPE--QLKMTVVKLISHREC 345
               S  +Q +CLP     P  GT C +TG+G       L PE   L+   V L+  R C
Sbjct: 135 PVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPL-PEWRPLQGVRVPLLDSRTC 193

Query: 346 QQPHYYGSEVTTK-------MLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGR 398
              ++ G++V           LCA  PQ   D+CQGDSGGPL C   G   L G+VSWG+
Sbjct: 194 DGLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGK 253

Query: 399 GCALKDKPGVYTRVSHFLPWIRS 421
           GCAL ++PGVYT V+ + PWI++
Sbjct: 254 GCALPNRPGVYTSVATYSPWIQA 276


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  162 bits (409), Expect = 7e-40
 Identities = 90/247 (36%), Positives = 137/247 (55%), Gaps = 17/247 (6%)

Query: 178 KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIV 237
           +I+GG      + PW  ++   +      + CGGSLI+  W+++A HCF       D+I 
Sbjct: 186 RILGGTEAEEGSWPWQVSLRLNN-----AHHCGGSLINNMWILTAAHCFRSNSNPRDWIA 240

Query: 238 YLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQT 297
             G S     T  +++  V N+++H +Y + T  H NDIAL+++ +        ++ I +
Sbjct: 241 TSGIS----TTFPKLRMRVRNILIHNNYKSAT--HENDIALVRLENS----VTFTKDIHS 290

Query: 298 ICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTT 357
           +CLP+   +   G++  +TG+G +    +  PE L+   V++IS+  C  PH Y   + +
Sbjct: 291 VCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPE-LRQGQVRIISNDVCNAPHSYNGAILS 349

Query: 358 KMLCAADPQWKTDSCQGDSGGPLVCSLQGRM-TLTGIVSWGRGCALKDKPGVYTRVSHFL 416
            MLCA  PQ   D+CQGDSGGPLV     R+  + GIVSWG  C L DKPGVYTRV+ +L
Sbjct: 350 GMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYL 409

Query: 417 PWIRSHT 423
            WIR  T
Sbjct: 410 DWIRQQT 416


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  159 bits (401), Expect = 6e-39
 Identities = 95/261 (36%), Positives = 136/261 (52%), Gaps = 18/261 (6%)

Query: 168 CGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFI 227
           CG + +  R  I+GG   +    PW  ++   H G   T++CGG+LI   WV++A HCF 
Sbjct: 317 CGLRAMTGR--IVGGALASDSKWPWQVSL---HFG--TTHICGGTLIDAQWVLTAAHCFF 369

Query: 228 DYPKK--EDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKE 285
              +K  E + VY G S L+   +      +  +I++ +Y+ +   +  DIAL+++    
Sbjct: 370 VTREKVLEGWKVYAGTSNLHQLPEAA---SIAEIIINSNYTDEEDDY--DIALMRL---- 420

Query: 286 GRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHREC 345
            +    S  I   CLP          +C ITGFGK   TD      L+   V LI  ++C
Sbjct: 421 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC 480

Query: 346 QQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDK 405
                Y S +T +M+CA D +   DSCQGDSGGPLVC    R  L G+ SWG GC  ++K
Sbjct: 481 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK 540

Query: 406 PGVYTRVSHFLPWIRSHTKEE 426
           PGVYT+V+  LPWI S  + E
Sbjct: 541 PGVYTKVTEVLPWIYSKMESE 561


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  154 bits (390), Expect = 1e-37
 Identities = 100/274 (36%), Positives = 148/274 (54%), Gaps = 25/274 (9%)

Query: 150 DCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVC 209
           DC DG       +E    CG +   P  +I+GG  ++    PW A++  R R     ++C
Sbjct: 556 DCRDGS------DEEHCDCGLQG--PSSRIVGGAVSSEGEWPWQASLQVRGR-----HIC 602

Query: 210 GGSLISPCWVISATHCFIDYPKKEDYI--VYLGRSRLNSNTQGEMKFEVENLILHKDYSA 267
           GG+LI+  WVI+A HCF +       +  V+LG+   NS   GE+ F+V  L+LH  +  
Sbjct: 603 GGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEE 662

Query: 268 DTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYL 327
           D+  H  D+ALL++     R A     ++ +CLP+  +  + G  C ITG+G       +
Sbjct: 663 DS--HDYDVALLQLDHPVVRSA----AVRPVCLPARSHFFEPGLHCWITGWGALREGGPI 716

Query: 328 YPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVC-SLQG 386
               L+   V+LI    C + + Y  +VT +MLCA   + K D+CQGDSGGPLVC +L G
Sbjct: 717 -SNALQKVDVQLIPQDLCSEVYRY--QVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSG 773

Query: 387 RMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR 420
           R  L G+VSWG GC   +  GVYTR++  + WI+
Sbjct: 774 RWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQ 807


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  153 bits (387), Expect = 3e-37
 Identities = 84/259 (32%), Positives = 143/259 (55%), Gaps = 10/259 (3%)

Query: 172 TLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPK 231
           T +   +I+GG  ++    PW  ++  +    +  ++CGGSLI   WV++A HCF   P 
Sbjct: 384 TTKTSTRIVGGTNSSWGEWPWQVSLQVKLT--AQRHLCGGSLIGHQWVLTAAHCFDGLPL 441

Query: 232 KEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQP 291
           ++ + +Y G   L+  T+     +++ +I+H++Y      H  DIAL+K+++        
Sbjct: 442 QDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNH--DIALIKLQAP----LNY 495

Query: 292 SRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYY 351
           +   + ICLPS  +     T+C +TG+G       +    L+   + L+++ ECQ+  Y 
Sbjct: 496 TEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQ-NILQKVNIPLVTNEECQK-RYQ 553

Query: 352 GSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTR 411
             ++T +M+CA   +   D+C+GDSGGPLVC   G   L GI SWG GCA +++PGVYT+
Sbjct: 554 DYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTK 613

Query: 412 VSHFLPWIRSHTKEENGLA 430
           V+ ++ WI   T+  +G A
Sbjct: 614 VAEYMDWILEKTQSSDGKA 632


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  152 bits (385), Expect = 4e-37
 Identities = 99/269 (36%), Positives = 137/269 (50%), Gaps = 29/269 (10%)

Query: 168 CGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFI 227
           CG   + P+ +I GG        PW  +I   + G    +VCGGSL+S  WV+SA HCF 
Sbjct: 37  CG---VAPQARITGGSSAVAGQWPWQVSI--TYEG---VHVCGGSLVSEQWVLSAAHCFP 88

Query: 228 DYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGR 287
               KE Y V LG  +L+S ++      ++++I H  Y  +      DIALL++     R
Sbjct: 89  SEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQE--GSQGDIALLQL----SR 142

Query: 288 CAQPSRTIQTICLPSMYNDPQFGTSCEITGFGK-ENSTDYLYPEQLKMTVVKLISHREC- 345
               SR I+ ICLP+       G  C +TG+G    S   L P+ L+   V LIS   C 
Sbjct: 143 PITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCN 202

Query: 346 ---------QQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSW 396
                    ++PH+    V   M+CA   +   D+CQGDSGGPL C ++G   LTGIVSW
Sbjct: 203 CLYNIDAKPEEPHF----VQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSW 258

Query: 397 GRGCALKDKPGVYTRVSHFLPWIRSHTKE 425
           G  C  +++PGVYT  S +  WI+S   E
Sbjct: 259 GDACGARNRPGVYTLASSYASWIQSKVTE 287


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  152 bits (385), Expect = 4e-37
 Identities = 94/276 (34%), Positives = 140/276 (50%), Gaps = 21/276 (7%)

Query: 150 DCADGKKPSSPPEELKFQCG-QKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYV 208
           DC+DG       +E   +CG Q   R   +I+GG   +    PW A++          + 
Sbjct: 179 DCSDGS------DEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKE-----HF 227

Query: 209 CGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSAD 268
           CG ++I+  W++SA HCF ++     ++ Y+G + L+ +    ++ +V  ++ H  Y+AD
Sbjct: 228 CGAAIINARWLVSAAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNAD 287

Query: 269 TLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLY 328
           T     D+A+L++ S         R IQ +CLP+  +       C I+G+G       + 
Sbjct: 288 TADF--DVAVLELTSP----LPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVK 341

Query: 329 PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVC-SLQGR 387
           PE L+   V+L+    C     YG  +T +M+CA     K DSCQGDSGGPLVC    GR
Sbjct: 342 PEVLQKATVELLDQALCAS--LYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGR 399

Query: 388 MTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHT 423
             L GIVSWG GCA   +PGVY RV+    WI   T
Sbjct: 400 FFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEAT 435



 Score =  150 bits (379), Expect = 2e-36
 Identities = 90/249 (36%), Positives = 133/249 (53%), Gaps = 16/249 (6%)

Query: 178  KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIV 237
            +I+GG        PW  +++ R R     + CG  L++  W++SA HCF  Y   + +  
Sbjct: 826  RIVGGSAAGRGEWPWQVSLWLRRR----EHRCGAVLVAERWLLSAAHCFDVYGDPKQWAA 881

Query: 238  YLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQT 297
            +LG   L S  +G+++  V  +  H  Y+  TL +  D+ALL++     R    SR ++ 
Sbjct: 882  FLGTPFL-SGAEGQLE-RVARIYKHPFYNLYTLDY--DVALLELAGPVRR----SRLVRP 933

Query: 298  ICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTT 357
            ICLP     P  GT C ITG+G       +   QL+   V+L+S + C++  +Y  ++++
Sbjct: 934  ICLPEPAPRPPDGTRCVITGWGSVREGGSM-ARQLQKAAVRLLSEQTCRR--FYPVQISS 990

Query: 358  KMLCAADPQWKTDSCQGDSGGPLVC-SLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFL 416
            +MLCA  PQ   DSC GD+GGPL C    GR  LTG+ SWG GC     PGVYTRV+   
Sbjct: 991  RMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVR 1050

Query: 417  PWIRSHTKE 425
             WI  H +E
Sbjct: 1051 GWIGQHIQE 1059



 Score =  133 bits (335), Expect = 3e-31
 Identities = 83/255 (32%), Positives = 125/255 (49%), Gaps = 16/255 (6%)

Query: 167 QCGQK-TLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHC 225
           +CG +  +    +++GG        PW  ++    R     + CG +++   W++SA HC
Sbjct: 491 ECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSR-----HFCGATVVGDRWLLSAAHC 545

Query: 226 FIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKE 285
           F ++ K E    +LG + L       +K  +  ++LH  Y+   L    D+A+L++ S  
Sbjct: 546 F-NHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDF--DLAVLELASPL 602

Query: 286 GRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHREC 345
                 ++ IQ +CLP        G  C I+G+G     +   PE L+   V +I  + C
Sbjct: 603 AF----NKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTC 658

Query: 346 QQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCS-LQGRMTLTGIVSWGRGCALKD 404
                Y   +T +M+CA   + K DSCQGDSGGPL C    G   L GIVSWG GCA   
Sbjct: 659 SV--LYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVK 716

Query: 405 KPGVYTRVSHFLPWI 419
           KPGVYTR++    WI
Sbjct: 717 KPGVYTRITRLKGWI 731


>gi|11496281 kallikrein 13 precursor [Homo sapiens]
          Length = 277

 Score =  152 bits (383), Expect = 7e-37
 Identities = 100/243 (41%), Positives = 133/243 (54%), Gaps = 24/243 (9%)

Query: 181 GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG 240
           GG      +QPW AA+  + R      +CGG L+ P WV++A HC      KE   VYLG
Sbjct: 38  GGYTCFPHSQPWQAALLVQGR-----LLCGGVLVHPKWVLTAAHCL-----KEGLKVYLG 87

Query: 241 RSRLNSNTQGEMKFEVENLILHKDY--SADTLAHHNDIALLKIRSKEGRCAQPSRTIQTI 298
           +  L     GE   EV + I H +Y  S   L H +DI LL+++S      Q +  IQT+
Sbjct: 88  KHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLELQSP----VQLTGYIQTL 143

Query: 299 CLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTK 358
            L S  N    GT+C ++G+G   S    YP+ L+   ++L S  EC+Q   Y  ++T  
Sbjct: 144 PL-SHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDEECRQ--VYPGKITDN 200

Query: 359 MLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGR-GCALKDKPGVYTRVSHFLP 417
           MLCA   +   DSC+GDSGGPLVC+     TL GIVSWG   C   D+PGVYTRVS ++ 
Sbjct: 201 MLCAGTKEGGKDSCEGDSGGPLVCN----RTLYGIVSWGDFPCGQPDRPGVYTRVSRYVL 256

Query: 418 WIR 420
           WIR
Sbjct: 257 WIR 259


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  149 bits (376), Expect = 5e-36
 Identities = 89/261 (34%), Positives = 135/261 (51%), Gaps = 16/261 (6%)

Query: 167 QCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCF 226
           +CG + L  R  I+GG+       PW A++    R     + CGGS+++P WV++A HC 
Sbjct: 208 ECGARPLASR--IVGGQSVAPGRWPWQASVALGFR-----HTCGGSVLAPRWVVTAAHCM 260

Query: 227 IDY--PKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSK 284
             +   +   + V+ G    +S  +      VE +I H  YSA    H  D+ALL++++ 
Sbjct: 261 HSFRLARLSSWRVHAGLVS-HSAVRPHQGALVERIIPHPLYSAQN--HDYDVALLRLQT- 316

Query: 285 EGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRE 344
                  S T+  +CLP+       G+ C ++G+G  + +     + L+ TVV L S + 
Sbjct: 317 ---ALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQL 373

Query: 345 CQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKD 404
           C     Y   +T +MLCA     + D+CQGDSGGPLVC       L G+VSWGRGCA  +
Sbjct: 374 CNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPN 433

Query: 405 KPGVYTRVSHFLPWIRSHTKE 425
            PGVY +V+ FL WI    ++
Sbjct: 434 HPGVYAKVAEFLDWIHDTAQD 454


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  145 bits (367), Expect = 5e-35
 Identities = 100/289 (34%), Positives = 153/289 (52%), Gaps = 30/289 (10%)

Query: 142 LVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHR 201
           L++   V DC  G+  ++  ++    CG++ L P  +I+GG  T++   PW  ++  R+ 
Sbjct: 131 LLEVISVCDCPRGRFLAAICQD----CGRRKL-PVDRIVGGRDTSLGRWPWQVSL--RYD 183

Query: 202 GGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLIL 261
           G    ++CGGSL+S  WV++A HCF +  +          +   ++  G ++  V+ ++ 
Sbjct: 184 GA---HLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHG-LQLGVQAVVY 239

Query: 262 HKDY----SADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITG 317
           H  Y      ++  + NDIAL+ + S        +  IQ +CLP+       G  C +TG
Sbjct: 240 HGGYLPFRDPNSEENSNDIALVHLSSP----LPLTEYIQPVCLPAAGQALVDGKICTVTG 295

Query: 318 FGKENSTDYLYPEQ---LKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQG 374
           +G   +T Y Y +Q   L+   V +IS+  C    +YG+++  KM CA  P+   D+CQG
Sbjct: 296 WG---NTQY-YGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQG 351

Query: 375 DSGGPLVC----SLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWI 419
           DSGGP VC    S   R  L GIVSWG GCAL  KPGVYT+VS F  WI
Sbjct: 352 DSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400


>gi|61744424 kallikrein-related peptidase 6 isoform A preproprotein
           [Homo sapiens]
          Length = 244

 Score =  145 bits (367), Expect = 5e-35
 Identities = 92/244 (37%), Positives = 128/244 (52%), Gaps = 27/244 (11%)

Query: 178 KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIV 237
           K++ G      + P+ AA+Y      S   +CGG LI P WV++A HC     KK +  V
Sbjct: 21  KLVHGGPCDKTSHPYQAALYT-----SGHLLCGGVLIHPLWVLTAAHC-----KKPNLQV 70

Query: 238 YLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQT 297
           +LG+  L      + +  V   ++H DY  D  +H  DI LL++     R A+ S  IQ 
Sbjct: 71  FLGKHNLRQRESSQEQSSVVRAVIHPDY--DAASHDQDIMLLRL----ARPAKLSELIQP 124

Query: 298 ICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTT 357
             LP   +     TSC I G+GK    D+  P+ ++   + L+S  EC+  H Y  ++T 
Sbjct: 125 --LPLERDCSANTTSCHILGWGKTADGDF--PDTIQCAYIHLVSREECE--HAYPGQITQ 178

Query: 358 KMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGR-GCALKDKPGVYTRVSHFL 416
            MLCA D ++  DSCQGDSGGPLVC       L G+VSWG   C  K+KPGVYT V  + 
Sbjct: 179 NMLCAGDEKYGKDSCQGDSGGPLVCGDH----LRGLVSWGNIPCGSKEKPGVYTNVCRYT 234

Query: 417 PWIR 420
            WI+
Sbjct: 235 NWIQ 238


>gi|4506155 kallikrein-related peptidase 6 isoform A preproprotein
           [Homo sapiens]
          Length = 244

 Score =  145 bits (367), Expect = 5e-35
 Identities = 92/244 (37%), Positives = 128/244 (52%), Gaps = 27/244 (11%)

Query: 178 KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIV 237
           K++ G      + P+ AA+Y      S   +CGG LI P WV++A HC     KK +  V
Sbjct: 21  KLVHGGPCDKTSHPYQAALYT-----SGHLLCGGVLIHPLWVLTAAHC-----KKPNLQV 70

Query: 238 YLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQT 297
           +LG+  L      + +  V   ++H DY  D  +H  DI LL++     R A+ S  IQ 
Sbjct: 71  FLGKHNLRQRESSQEQSSVVRAVIHPDY--DAASHDQDIMLLRL----ARPAKLSELIQP 124

Query: 298 ICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTT 357
             LP   +     TSC I G+GK    D+  P+ ++   + L+S  EC+  H Y  ++T 
Sbjct: 125 --LPLERDCSANTTSCHILGWGKTADGDF--PDTIQCAYIHLVSREECE--HAYPGQITQ 178

Query: 358 KMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGR-GCALKDKPGVYTRVSHFL 416
            MLCA D ++  DSCQGDSGGPLVC       L G+VSWG   C  K+KPGVYT V  + 
Sbjct: 179 NMLCAGDEKYGKDSCQGDSGGPLVCGDH----LRGLVSWGNIPCGSKEKPGVYTNVCRYT 234

Query: 417 PWIR 420
            WI+
Sbjct: 235 NWIQ 238


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  145 bits (367), Expect = 5e-35
 Identities = 100/289 (34%), Positives = 153/289 (52%), Gaps = 30/289 (10%)

Query: 142 LVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHR 201
           L++   V DC  G+  ++  ++    CG++ L P  +I+GG  T++   PW  ++  R+ 
Sbjct: 131 LLEVISVCDCPRGRFLAAICQD----CGRRKL-PVDRIVGGRDTSLGRWPWQVSL--RYD 183

Query: 202 GGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLIL 261
           G    ++CGGSL+S  WV++A HCF +  +          +   ++  G ++  V+ ++ 
Sbjct: 184 GA---HLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHG-LQLGVQAVVY 239

Query: 262 HKDY----SADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITG 317
           H  Y      ++  + NDIAL+ + S        +  IQ +CLP+       G  C +TG
Sbjct: 240 HGGYLPFRDPNSEENSNDIALVHLSSP----LPLTEYIQPVCLPAAGQALVDGKICTVTG 295

Query: 318 FGKENSTDYLYPEQ---LKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQG 374
           +G   +T Y Y +Q   L+   V +IS+  C    +YG+++  KM CA  P+   D+CQG
Sbjct: 296 WG---NTQY-YGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQG 351

Query: 375 DSGGPLVC----SLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWI 419
           DSGGP VC    S   R  L GIVSWG GCAL  KPGVYT+VS F  WI
Sbjct: 352 DSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400


>gi|205277383 macrophage stimulating 1 (hepatocyte growth
           factor-like) [Homo sapiens]
          Length = 725

 Score =  144 bits (364), Expect = 1e-34
 Identities = 110/367 (29%), Positives = 165/367 (44%), Gaps = 41/367 (11%)

Query: 66  KSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNP 125
           + + CY G G  YRG  S    G  C  W++ T  +  +        QL   + N+CRNP
Sbjct: 380 RPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQL---EENFCRNP 436

Query: 126 D-NRRRPWCYVQVGLKPLVQECMVHDCADGKKPS--SPPEELKFQ-CGQKT-----LRPR 176
           D +   PWCY      P    C +  CAD + PS   PP++++F+ CG++       R +
Sbjct: 437 DGDSHGPWCYTMDPRTPF-DYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRSK 495

Query: 177 FKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID-YPKKEDY 235
            +++GG      N PW  ++  R+R G   + CGGSL+   W+++A  CF   +     Y
Sbjct: 496 LRVVGGH---PGNSPWTVSL--RNRQGQ--HFCGGSLVKEQWILTARQCFSSCHMPLTGY 548

Query: 236 IVYLGRSRLNSNTQGEMKFE---VENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPS 292
            V+LG    N    GE   +   V  ++     S         + LLK+     R    +
Sbjct: 549 EVWLGTLFQNPQ-HGEPSLQRVPVAKMVCGPSGS--------QLVLLKLE----RSVTLN 595

Query: 293 RTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYG 352
           + +  ICLP  +     GT CEI G+G+   T       L + ++ +IS++EC   H   
Sbjct: 596 QRVALICLPPEWYVVPPGTKCEIAGWGETKGTGN--DTVLNVALLNVISNQECNIKHR-- 651

Query: 353 SEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRV 412
             V    +C         +C+GD GGPL C       L GI+   R CA    P V+TRV
Sbjct: 652 GRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRV 711

Query: 413 SHFLPWI 419
           S F+ WI
Sbjct: 712 SVFVDWI 718



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 9/92 (9%)

Query: 69  TCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNR 128
           +C+ G G  YRG A+T T G PC  W++    Q  +   +     L   + N+CRNPD  
Sbjct: 296 SCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDL---RENFCRNPDGS 352

Query: 129 RRPWCYVQVGLKPLVQEC---MVHDCADGKKP 157
             PWC+    L+P ++      +  C D  +P
Sbjct: 353 EAPWCFT---LRPGMRAAFCYQIRRCTDDVRP 381



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 46/158 (29%), Positives = 58/158 (36%), Gaps = 20/158 (12%)

Query: 60  QHCEIDKSK--TCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLG 117
           Q C I   +   C   NG  YRG       GR C  W+     Q  +   +   L  GL 
Sbjct: 193 QSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKF--LDQGLD 250

Query: 118 KHNYCRNPDNRRRPWCYVQVGLKPLVQE--CMVHDCADGKKPSSPPEELKFQCGQKTLRP 175
             NYCRNPD   RPWCY      P ++   C +  C    +P    E     C     R 
Sbjct: 251 D-NYCRNPDGSERPWCYT---TDPQIEREFCDLPRCGSEAQPRQ--EATTVSC----FRG 300

Query: 176 RFKIIGGEFTT----IENQPWFAAIYRRHRGGSVTYVC 209
           + +   G   T    +  Q W A I  +HR     Y C
Sbjct: 301 KGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYAC 338



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 32/92 (34%), Positives = 42/92 (45%), Gaps = 11/92 (11%)

Query: 65  DKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRN 124
           D  +TC   NG  YRG  +T   G PC  W+        Y    +  L+ GL + N+CRN
Sbjct: 119 DYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKY----TPTLRNGL-EENFCRN 173

Query: 125 PD-NRRRPWCYVQVGLKPLV--QECMVHDCAD 153
           PD +   PWCY      P V  Q C +  C +
Sbjct: 174 PDGDPGGPWCYT---TDPAVRFQSCGIKSCRE 202


>gi|118498341 chymotrypsin B1 [Homo sapiens]
          Length = 263

 Score =  142 bits (359), Expect = 4e-34
 Identities = 86/259 (33%), Positives = 132/259 (50%), Gaps = 22/259 (8%)

Query: 166 FQCGQKTLRPRF----KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVIS 221
           F CG   + P      +I+ GE     + PW  ++  +    +  + CGGSLIS  WV++
Sbjct: 17  FGCGVPAIHPVLSGLSRIVNGEDAVPGSWPWQVSLQDK----TGFHFCGGSLISEDWVVT 72

Query: 222 ATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI 281
           A HC +    +   +V  G     S+ +     ++  +  +  +S  T+  +NDI LLK+
Sbjct: 73  AAHCGV----RTSDVVVAGEFDQGSDEENIQVLKIAKVFKNPKFSILTV--NNDITLLKL 126

Query: 282 RSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLIS 341
            +     A+ S+T+  +CLPS  +D   GT C  TG+GK        P++L+   + L+S
Sbjct: 127 ATP----ARFSQTVSAVCLPSADDDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLS 182

Query: 342 HRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCA 401
           + EC++   +G  +T  M+CA        SC GDSGGPLVC   G  TL GIVSWG    
Sbjct: 183 NAECKKS--WGRRITDVMICAGASG--VSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTC 238

Query: 402 LKDKPGVYTRVSHFLPWIR 420
               PGVY RV+  +PW++
Sbjct: 239 STSSPGVYARVTKLIPWVQ 257


>gi|4503137 chymotrypsin-like [Homo sapiens]
          Length = 264

 Score =  142 bits (358), Expect = 6e-34
 Identities = 89/257 (34%), Positives = 132/257 (51%), Gaps = 23/257 (8%)

Query: 168 CGQKTLRPRF----KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISAT 223
           CG   ++P      +I+ GE   + + PW  ++    +  S  + CGGSLIS  WV++A 
Sbjct: 19  CGIPAIKPALSFSQRIVNGENAVLGSWPWQVSL----QDSSGFHFCGGSLISQSWVVTAA 74

Query: 224 HCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRS 283
           HC +   +   + V LG    +SN +      V   I H  +++ T+  +ND+ LLK+ S
Sbjct: 75  HCNVSPGR---HFVVLGEYDRSSNAEPLQVLSVSRAITHPSWNSTTM--NNDVTLLKLAS 129

Query: 284 KEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHR 343
                AQ +  I  +CL S       G +C  TG+G+ +    + P  L+   + L++  
Sbjct: 130 P----AQYTTRISPVCLASSNEALTEGLTCVTTGWGRLSGVGNVTPAHLQQVALPLVTVN 185

Query: 344 ECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWG-RGCAL 402
           +C+Q  Y+GS +T  M+CA        SCQGDSGGPLVC       L GIVSWG + C +
Sbjct: 186 QCRQ--YWGSSITDSMICAGGAG--ASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNCNV 241

Query: 403 KDKPGVYTRVSHFLPWI 419
           +  P VYTRVS F  WI
Sbjct: 242 R-APAVYTRVSKFSTWI 257


>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
          Length = 247

 Score =  142 bits (357), Expect = 8e-34
 Identities = 88/244 (36%), Positives = 130/244 (53%), Gaps = 25/244 (10%)

Query: 178 KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIV 237
           KI+GG      + P+  ++       S  + CGGSLI+  WV+SA HC+     K    V
Sbjct: 23  KIVGGYNCEENSVPYQVSL------NSGYHFCGGSLINEQWVVSAGHCY-----KSRIQV 71

Query: 238 YLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQT 297
            LG   +      E       +I H  Y   TL  +NDI L+K+ S+    A  +  + T
Sbjct: 72  RLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTL--NNDIMLIKLSSR----AVINARVST 125

Query: 298 ICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTT 357
           I LP+    P  GT C I+G+G   S+   YP++L+     ++S  +C+    Y  ++T+
Sbjct: 126 ISLPTA--PPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEAS--YPGKITS 181

Query: 358 KMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLP 417
            M C    +   DSCQGDSGGP+VC+ Q    L G+VSWG GCA K+KPGVYT+V +++ 
Sbjct: 182 NMFCVGFLEGGKDSCQGDSGGPVVCNGQ----LQGVVSWGDGCAQKNKPGVYTKVYNYVK 237

Query: 418 WIRS 421
           WI++
Sbjct: 238 WIKN 241


>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
          Length = 304

 Score =  142 bits (357), Expect = 8e-34
 Identities = 92/244 (37%), Positives = 130/244 (53%), Gaps = 27/244 (11%)

Query: 178 KIIGGEFTTIENQ-PWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYI 236
           KI+GG +T  EN  P+  ++       S ++ CGGSLIS  WV+SA HC+     K    
Sbjct: 80  KIVGG-YTCEENSLPYQVSL------NSGSHFCGGSLISEQWVVSAAHCY-----KTRIQ 127

Query: 237 VYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQ 296
           V LG   +      E       +I H  Y+ DTL   NDI L+K+ S     A  +  + 
Sbjct: 128 VRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTL--DNDIMLIKLSSP----AVINARVS 181

Query: 297 TICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVT 356
           TI LP+    P  GT C I+G+G   S    YP++LK     +++  EC+    Y  ++T
Sbjct: 182 TISLPTA--PPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKAS--YPGKIT 237

Query: 357 TKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFL 416
             M C    +   DSCQ DSGGP+VC+ Q    L G+VSWG GCA K++PGVYT+V +++
Sbjct: 238 NSMFCVGFLEGGKDSCQRDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYV 293

Query: 417 PWIR 420
            WI+
Sbjct: 294 DWIK 297


>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  142 bits (357), Expect = 8e-34
 Identities = 92/244 (37%), Positives = 130/244 (53%), Gaps = 27/244 (11%)

Query: 178 KIIGGEFTTIENQ-PWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYI 236
           KI+GG +T  EN  P+  ++       S ++ CGGSLIS  WV+SA HC+     K    
Sbjct: 23  KIVGG-YTCEENSLPYQVSL------NSGSHFCGGSLISEQWVVSAAHCY-----KTRIQ 70

Query: 237 VYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQ 296
           V LG   +      E       +I H  Y+ DTL   NDI L+K+ S     A  +  + 
Sbjct: 71  VRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTL--DNDIMLIKLSSP----AVINARVS 124

Query: 297 TICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVT 356
           TI LP+    P  GT C I+G+G   S    YP++LK     +++  EC+    Y  ++T
Sbjct: 125 TISLPTA--PPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKAS--YPGKIT 180

Query: 357 TKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFL 416
             M C    +   DSCQ DSGGP+VC+ Q    L G+VSWG GCA K++PGVYT+V +++
Sbjct: 181 NSMFCVGFLEGGKDSCQRDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYV 236

Query: 417 PWIR 420
            WI+
Sbjct: 237 DWIK 240


>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
          Length = 321

 Score =  142 bits (357), Expect = 8e-34
 Identities = 91/254 (35%), Positives = 123/254 (48%), Gaps = 19/254 (7%)

Query: 178 KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIV 237
           +I+GG        PW A++  R       +VCGGSL+SP WV++A HCF       DY V
Sbjct: 37  RIVGGHAAPAGAWPWQASLRLRR-----VHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQV 91

Query: 238 YLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQT 297
           +LG   +  +        V  +ILH   S        DIAL+++          S  I  
Sbjct: 92  HLGELEITLSPHFST---VRQIILHSSPSGQP-GTSGDIALVELSVP----VTLSSRILP 143

Query: 298 ICLPSMYNDPQFGTSCEITGFGKENSTDYLYPE-QLKMTVVKLISHRECQQ--PHYYGSE 354
           +CLP   +D   G  C +TG+G     + L P   L+   V ++    C++  P   GS 
Sbjct: 144 VCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSI 203

Query: 355 VTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSH 414
           +   MLCA  P    D+CQ DSGGPLVC + G     GIVSWG GC   ++PGVYTRV  
Sbjct: 204 LQPDMLCARGPG---DACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPA 260

Query: 415 FLPWIRSHTKEENG 428
           ++ WIR H     G
Sbjct: 261 YVNWIRRHITASGG 274


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.449 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,811,809
Number of Sequences: 37866
Number of extensions: 905520
Number of successful extensions: 2809
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 185
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 1743
Number of HSP's gapped (non-prelim): 641
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.