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Search of human proteins with 4505785
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo
sapiens]
(406 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens] 828 0.0
gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens] 512 e-145
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 209 5e-54
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 207 1e-53
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 207 1e-53
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 207 1e-53
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 207 1e-53
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 207 1e-53
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 207 1e-53
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma... 205 7e-53
gi|26667191 calcium/calmodulin-dependent protein kinase II gamma... 205 7e-53
gi|26667211 calcium/calmodulin-dependent protein kinase II gamma... 205 7e-53
gi|26667203 calcium/calmodulin-dependent protein kinase II gamma... 205 7e-53
gi|26667196 calcium/calmodulin-dependent protein kinase II gamma... 205 7e-53
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ... 204 9e-53
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ... 204 9e-53
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ... 204 9e-53
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ... 204 9e-53
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ... 204 9e-53
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ... 204 9e-53
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ... 204 9e-53
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ... 204 9e-53
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha... 202 4e-52
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha... 202 4e-52
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 196 3e-50
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 195 5e-50
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 195 5e-50
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 191 1e-48
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 191 1e-48
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 190 2e-48
>gi|4505785 phosphorylase kinase, gamma 2 (testis) [Homo sapiens]
Length = 406
Score = 828 bits (2138), Expect = 0.0
Identities = 406/406 (100%), Positives = 406/406 (100%)
Query: 1 MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE 60
MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE
Sbjct: 1 MTLDVGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE 60
Query: 61 RLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT 120
RLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT
Sbjct: 61 RLSPEQLEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLT 120
Query: 121 EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEP 180
EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEP
Sbjct: 121 EKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEP 180
Query: 181 GEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL 240
GEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL
Sbjct: 181 GEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL 240
Query: 241 MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPW 300
MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPW
Sbjct: 241 MLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPW 300
Query: 301 NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGH 360
NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGH
Sbjct: 301 NLTPRQRFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGH 360
Query: 361 WVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG 406
WVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG
Sbjct: 361 WVKKGEQQNRAALFQHRPPGPFPIMGPEEEGDSAAITEDEAVLVLG 406
>gi|5453882 phosphorylase kinase gamma subunit 1 [Homo sapiens]
Length = 387
Score = 512 bits (1319), Expect = e-145
Identities = 240/372 (64%), Positives = 306/372 (82%), Gaps = 1/372 (0%)
Query: 8 EDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAE-RLSPEQ 66
++ LPD +A++FY+ Y+PK+++GRGVSSVVRRC+H+ T E+AVK+++VT SPE+
Sbjct: 4 DEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEE 63
Query: 67 LEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALS 126
+ E+REAT +E ILR+V+GHP+II L D+YE+++F FLVFDLM++GELFDYLTEKV LS
Sbjct: 64 VRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLS 123
Query: 127 EKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRE 186
EKETR IMR+LLE + LH NIVHRDLKPENILLDDNM I+L+DFGFSC LEPGE+LRE
Sbjct: 124 EKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLRE 183
Query: 187 LCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIM 246
+CGTP YLAPEI++CSM+E HPGYGKEVD+W+ GVI++TLLAGSPPFWHR+Q+LMLRMIM
Sbjct: 184 VCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM 243
Query: 247 EGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
G YQF SPEWDD S TVKDL+SR L V P+ R TAE+AL HPFF++ + + +PR
Sbjct: 244 SGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFSPRG 303
Query: 307 RFRVAVWTVLAAGRVALSTHRVRPLTKNALLRDPYALRSVRHLIDNCAFRLYGHWVKKGE 366
+F+V TVLA+ R+ RV+P+T+ ++RDPYALR +R LID AFR+YGHWVKKG+
Sbjct: 304 KFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQ 363
Query: 367 QQNRAALFQHRP 378
QQNRAALF++ P
Sbjct: 364 QQNRAALFENTP 375
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 209 bits (531), Expect = 5e-54
Identities = 114/284 (40%), Positives = 161/284 (56%), Gaps = 17/284 (5%)
Query: 10 ELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEE 69
E P W A++ YD +DV+G G S V + T A+K ++ E LE
Sbjct: 6 EGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKC-------IAKEALEG 58
Query: 70 VREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKE 129
+ E +L ++ HP+I+ L D YES ++L+ L+ GELFD + EK +E++
Sbjct: 59 KEGSMENEIAVLHKIK-HPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERD 117
Query: 130 TRSIMRSLLEAVSFLHANNIVHRDLKPENIL---LDDNMQIRLSDFGFSCHLEPGEKLRE 186
++ +L+AV +LH IVHRDLKPEN+L LD++ +I +SDFG S +PG L
Sbjct: 118 ASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLST 177
Query: 187 LCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIM 246
CGTPGY+APE+L Y K VD W+ GVI + LL G PPF+ + I+
Sbjct: 178 ACGTPGYVAPEVL------AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQIL 231
Query: 247 EGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPF 290
+ +Y+F SP WDD S + KD I L++ DPE R T EQALQHP+
Sbjct: 232 KAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPW 275
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 207 bits (527), Expect = 1e-53
Identities = 116/291 (39%), Positives = 172/291 (59%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + +G+G SVVRRC+ TG E+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
+V+ H N IVHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + KDLI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI--CQRSTVASMMHRQ 285
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 207 bits (527), Expect = 1e-53
Identities = 116/291 (39%), Positives = 172/291 (59%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + +G+G SVVRRC+ TG E+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
+V+ H N IVHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + KDLI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI--CQRSTVASMMHRQ 285
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 207 bits (527), Expect = 1e-53
Identities = 116/291 (39%), Positives = 172/291 (59%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + +G+G SVVRRC+ TG E+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
+V+ H N IVHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + KDLI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI--CQRSTVASMMHRQ 285
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 207 bits (527), Expect = 1e-53
Identities = 116/291 (39%), Positives = 172/291 (59%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + +G+G SVVRRC+ TG E+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
+V+ H N IVHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + KDLI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI--CQRSTVASMMHRQ 285
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 207 bits (527), Expect = 1e-53
Identities = 116/291 (39%), Positives = 172/291 (59%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + +G+G SVVRRC+ TG E+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
+V+ H N IVHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + KDLI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI--CQRSTVASMMHRQ 285
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 207 bits (527), Expect = 1e-53
Identities = 116/291 (39%), Positives = 172/291 (59%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + +G+G SVVRRC+ TG E+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
+V+ H N IVHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + KDLI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI--CQRSTVASMMHRQ 285
>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
isoform 3 [Homo sapiens]
Length = 518
Score = 205 bits (521), Expect = 7e-53
Identities = 117/297 (39%), Positives = 175/297 (58%), Gaps = 21/297 (7%)
Query: 15 AAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREAT 74
A F Y + +G+G SVVRRCV + + E+A KI + ++LS +++
Sbjct: 5 ATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI--INTKKLSARDHQKLE--- 59
Query: 75 RRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIM 134
RE I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + +
Sbjct: 60 -REARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCI 117
Query: 135 RSLLEAVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR--ELCG 189
+LE+V+ +H ++IVHRDLKPEN+LL + ++L+DFG + ++ GE+ G
Sbjct: 118 HQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAG 176
Query: 190 TPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQ 249
TPGYL+PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G
Sbjct: 177 TPGYLSPEVLR------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA 230
Query: 250 YQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
Y F SPEWD + K+LI+++L ++P R+TA+QAL+HP+ C+ S ++ RQ
Sbjct: 231 YDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV--CQRSTVASMMHRQ 285
>gi|26667191 calcium/calmodulin-dependent protein kinase II gamma
isoform 4 [Homo sapiens]
Length = 495
Score = 205 bits (521), Expect = 7e-53
Identities = 117/297 (39%), Positives = 175/297 (58%), Gaps = 21/297 (7%)
Query: 15 AAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREAT 74
A F Y + +G+G SVVRRCV + + E+A KI + ++LS +++
Sbjct: 5 ATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI--INTKKLSARDHQKLE--- 59
Query: 75 RRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIM 134
RE I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + +
Sbjct: 60 -REARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCI 117
Query: 135 RSLLEAVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR--ELCG 189
+LE+V+ +H ++IVHRDLKPEN+LL + ++L+DFG + ++ GE+ G
Sbjct: 118 HQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAG 176
Query: 190 TPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQ 249
TPGYL+PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G
Sbjct: 177 TPGYLSPEVLR------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA 230
Query: 250 YQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
Y F SPEWD + K+LI+++L ++P R+TA+QAL+HP+ C+ S ++ RQ
Sbjct: 231 YDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV--CQRSTVASMMHRQ 285
>gi|26667211 calcium/calmodulin-dependent protein kinase II gamma
isoform 6 [Homo sapiens]
Length = 504
Score = 205 bits (521), Expect = 7e-53
Identities = 117/297 (39%), Positives = 175/297 (58%), Gaps = 21/297 (7%)
Query: 15 AAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREAT 74
A F Y + +G+G SVVRRCV + + E+A KI + ++LS +++
Sbjct: 5 ATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI--INTKKLSARDHQKLE--- 59
Query: 75 RRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIM 134
RE I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + +
Sbjct: 60 -REARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCI 117
Query: 135 RSLLEAVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR--ELCG 189
+LE+V+ +H ++IVHRDLKPEN+LL + ++L+DFG + ++ GE+ G
Sbjct: 118 HQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAG 176
Query: 190 TPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQ 249
TPGYL+PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G
Sbjct: 177 TPGYLSPEVLR------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA 230
Query: 250 YQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
Y F SPEWD + K+LI+++L ++P R+TA+QAL+HP+ C+ S ++ RQ
Sbjct: 231 YDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV--CQRSTVASMMHRQ 285
>gi|26667203 calcium/calmodulin-dependent protein kinase II gamma
isoform 1 [Homo sapiens]
Length = 556
Score = 205 bits (521), Expect = 7e-53
Identities = 117/297 (39%), Positives = 175/297 (58%), Gaps = 21/297 (7%)
Query: 15 AAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREAT 74
A F Y + +G+G SVVRRCV + + E+A KI + ++LS +++
Sbjct: 5 ATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI--INTKKLSARDHQKLE--- 59
Query: 75 RRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIM 134
RE I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + +
Sbjct: 60 -REARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCI 117
Query: 135 RSLLEAVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR--ELCG 189
+LE+V+ +H ++IVHRDLKPEN+LL + ++L+DFG + ++ GE+ G
Sbjct: 118 HQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAG 176
Query: 190 TPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQ 249
TPGYL+PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G
Sbjct: 177 TPGYLSPEVLR------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA 230
Query: 250 YQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
Y F SPEWD + K+LI+++L ++P R+TA+QAL+HP+ C+ S ++ RQ
Sbjct: 231 YDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV--CQRSTVASMMHRQ 285
>gi|26667196 calcium/calmodulin-dependent protein kinase II gamma
isoform 2 [Homo sapiens]
Length = 527
Score = 205 bits (521), Expect = 7e-53
Identities = 117/297 (39%), Positives = 175/297 (58%), Gaps = 21/297 (7%)
Query: 15 AAAKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREAT 74
A F Y + +G+G SVVRRCV + + E+A KI + ++LS +++
Sbjct: 5 ATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKI--INTKKLSARDHQKLE--- 59
Query: 75 RRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIM 134
RE I R + HP+I+ L DS F +LVFDL+ GELF+ + + SE + +
Sbjct: 60 -REARICRLLK-HPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCI 117
Query: 135 RSLLEAVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR--ELCG 189
+LE+V+ +H ++IVHRDLKPEN+LL + ++L+DFG + ++ GE+ G
Sbjct: 118 HQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAG 176
Query: 190 TPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQ 249
TPGYL+PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G
Sbjct: 177 TPGYLSPEVLR------KDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA 230
Query: 250 YQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
Y F SPEWD + K+LI+++L ++P R+TA+QAL+HP+ C+ S ++ RQ
Sbjct: 231 YDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWV--CQRSTVASMMHRQ 285
>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
isoform 1 [Homo sapiens]
Length = 666
Score = 204 bits (520), Expect = 9e-53
Identities = 116/291 (39%), Positives = 170/291 (58%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + IG+G SVVRRCV TGHE+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + H +I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
AV H +VHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + K+LI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV--CQRSTVASMMHRQ 285
>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
isoform 4 [Homo sapiens]
Length = 517
Score = 204 bits (520), Expect = 9e-53
Identities = 116/291 (39%), Positives = 170/291 (58%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + IG+G SVVRRCV TGHE+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + H +I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
AV H +VHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + K+LI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV--CQRSTVASMMHRQ 285
>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
isoform 6 [Homo sapiens]
Length = 492
Score = 204 bits (520), Expect = 9e-53
Identities = 116/291 (39%), Positives = 170/291 (58%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + IG+G SVVRRCV TGHE+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + H +I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
AV H +VHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + K+LI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV--CQRSTVASMMHRQ 285
>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
isoform 2 [Homo sapiens]
Length = 542
Score = 204 bits (520), Expect = 9e-53
Identities = 116/291 (39%), Positives = 170/291 (58%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + IG+G SVVRRCV TGHE+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + H +I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
AV H +VHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + K+LI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV--CQRSTVASMMHRQ 285
>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
isoform 7 [Homo sapiens]
Length = 479
Score = 204 bits (520), Expect = 9e-53
Identities = 116/291 (39%), Positives = 170/291 (58%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + IG+G SVVRRCV TGHE+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + H +I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
AV H +VHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + K+LI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV--CQRSTVASMMHRQ 285
>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
isoform 8 [Homo sapiens]
Length = 449
Score = 204 bits (520), Expect = 9e-53
Identities = 116/291 (39%), Positives = 170/291 (58%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + IG+G SVVRRCV TGHE+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + H +I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
AV H +VHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + K+LI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV--CQRSTVASMMHRQ 285
>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
isoform 5 [Homo sapiens]
Length = 503
Score = 204 bits (520), Expect = 9e-53
Identities = 116/291 (39%), Positives = 170/291 (58%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + IG+G SVVRRCV TGHE+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + H +I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
AV H +VHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + K+LI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV--CQRSTVASMMHRQ 285
>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
isoform 3 [Homo sapiens]
Length = 518
Score = 204 bits (520), Expect = 9e-53
Identities = 116/291 (39%), Positives = 170/291 (58%), Gaps = 19/291 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F +Y + IG+G SVVRRCV TGHE+A KI + ++LS +++ RE
Sbjct: 10 FTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKI--INTKKLSARDHQKLE----REAR 63
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + H +I+ L DS F +LVFDL+ GELF+ + + SE + ++ +LE
Sbjct: 64 ICRLLK-HSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILE 122
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR-ELCGTPGYLA 195
AV H +VHRDLKPEN+LL + ++L+DFG + ++ ++ GTPGYL+
Sbjct: 123 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 182
Query: 196 PEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSP 255
PE+L+ YGK VD+WACGVIL+ LL G PPFW Q + + I G Y F SP
Sbjct: 183 PEVLR------KEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSP 236
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFERCEGSQPWNLTPRQ 306
EWD + K+LI+++L ++P R+TA +AL+HP+ C+ S ++ RQ
Sbjct: 237 EWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWV--CQRSTVASMMHRQ 285
>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
isoform 2 [Homo sapiens]
Length = 478
Score = 202 bits (514), Expect = 4e-52
Identities = 113/276 (40%), Positives = 164/276 (59%), Gaps = 19/276 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F ++Y + +G+G SVVRRCV G E+A KI + ++LS +++ RE
Sbjct: 9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKI--INTKKLSARDHQKLE----REAR 62
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + HP+I+ L DS +L+FDL+ GELF+ + + SE + ++ +LE
Sbjct: 63 ICRLLK-HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILE 121
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR--ELCGTPGYL 194
AV H +VHRDLKPEN+LL ++ ++L+DFG + +E GE+ GTPGYL
Sbjct: 122 AVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVE-GEQQAWFGFAGTPGYL 180
Query: 195 APEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSS 254
+PE+L+ YGK VDLWACGVIL+ LL G PPFW Q + + I G Y F S
Sbjct: 181 SPEVLR------KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPS 234
Query: 255 PEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPF 290
PEWD + KDLI+++L ++P R+TA +AL+HP+
Sbjct: 235 PEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPW 270
>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
isoform 1 [Homo sapiens]
Length = 489
Score = 202 bits (514), Expect = 4e-52
Identities = 113/276 (40%), Positives = 164/276 (59%), Gaps = 19/276 (6%)
Query: 20 FYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETH 79
F ++Y + +G+G SVVRRCV G E+A KI + ++LS +++ RE
Sbjct: 9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKI--INTKKLSARDHQKLE----REAR 62
Query: 80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLE 139
I R + HP+I+ L DS +L+FDL+ GELF+ + + SE + ++ +LE
Sbjct: 63 ICRLLK-HPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILE 121
Query: 140 AVSFLHANNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKLR--ELCGTPGYL 194
AV H +VHRDLKPEN+LL ++ ++L+DFG + +E GE+ GTPGYL
Sbjct: 122 AVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVE-GEQQAWFGFAGTPGYL 180
Query: 195 APEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSS 254
+PE+L+ YGK VDLWACGVIL+ LL G PPFW Q + + I G Y F S
Sbjct: 181 SPEVLR------KDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPS 234
Query: 255 PEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPF 290
PEWD + KDLI+++L ++P R+TA +AL+HP+
Sbjct: 235 PEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPW 270
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 196 bits (498), Expect = 3e-50
Identities = 117/319 (36%), Positives = 187/319 (58%), Gaps = 34/319 (10%)
Query: 24 YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQ 83
++ + +GRG +S+V RC + T +A+K+++ T ++ + R E +L +
Sbjct: 46 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDK----------KIVRTEIGVLLR 95
Query: 84 VAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSF 143
++ HP+II L + +E+ + + LV +L+ GELFD + EK SE++ ++ +LEAV++
Sbjct: 96 LS-HPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAY 154
Query: 144 LHANNIVHRDLKPENILL---DDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILK 200
LH N IVHRDLKPEN+L + ++++DFG S +E ++ +CGTPGY APEIL+
Sbjct: 155 LHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILR 214
Query: 201 -CSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRR-QILMLRMIMEGQYQFSSPEWD 258
C+ YG EVD+W+ G+I + LL G PF+ R M R I+ +Y F SP WD
Sbjct: 215 GCA-------YGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWD 267
Query: 259 DRSSTVKDLISRLLQVDPEARLTAEQALQHPF-------FERCEGSQP--WNLTPRQRFR 309
+ S KDL+ +L+ +DP+ RLT QALQHP+ F + +Q R++ +
Sbjct: 268 EVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLK 327
Query: 310 VAVWTVLAAGRV--ALSTH 326
AV V+A+ R+ A S+H
Sbjct: 328 AAVKAVVASSRLGSASSSH 346
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 195 bits (496), Expect = 5e-50
Identities = 108/277 (38%), Positives = 158/277 (57%), Gaps = 17/277 (6%)
Query: 17 AKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRR 76
A++ + ++ K+ +G G S V +ATG FAVK + A + +E
Sbjct: 16 AEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIEN------- 68
Query: 77 ETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 136
E +LR++ H +I+ L D YES + ++LV L+ GELFD + EK +EK+ +++R
Sbjct: 69 EIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQ 127
Query: 137 LLEAVSFLHANNIVHRDLKPENILL---DDNMQIRLSDFGFSCHLEPGEKLRELCGTPGY 193
+L+AV +LH IVHRDLKPEN+L D+ +I +SDFG S G+ + CGTPGY
Sbjct: 128 VLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGY 187
Query: 194 LAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFS 253
+APE+L Y K VD W+ GVI + LL G PPF+ + I++ +Y+F
Sbjct: 188 VAPEVL------AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFD 241
Query: 254 SPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPF 290
SP WDD S + KD I L++ DP R T EQA +HP+
Sbjct: 242 SPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPW 278
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 195 bits (496), Expect = 5e-50
Identities = 108/277 (38%), Positives = 158/277 (57%), Gaps = 17/277 (6%)
Query: 17 AKEFYQKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRR 76
A++ + ++ K+ +G G S V +ATG FAVK + A + +E
Sbjct: 16 AEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIEN------- 68
Query: 77 ETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRS 136
E +LR++ H +I+ L D YES + ++LV L+ GELFD + EK +EK+ +++R
Sbjct: 69 EIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQ 127
Query: 137 LLEAVSFLHANNIVHRDLKPENILL---DDNMQIRLSDFGFSCHLEPGEKLRELCGTPGY 193
+L+AV +LH IVHRDLKPEN+L D+ +I +SDFG S G+ + CGTPGY
Sbjct: 128 VLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGY 187
Query: 194 LAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFS 253
+APE+L Y K VD W+ GVI + LL G PPF+ + I++ +Y+F
Sbjct: 188 VAPEVL------AQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFD 241
Query: 254 SPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPF 290
SP WDD S + KD I L++ DP R T EQA +HP+
Sbjct: 242 SPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPW 278
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 191 bits (485), Expect = 1e-48
Identities = 110/275 (40%), Positives = 169/275 (61%), Gaps = 22/275 (8%)
Query: 22 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 81
+KY VIG G +VV+ C+ R+TG EFA+KI++ A+ E L E E IL
Sbjct: 391 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIID-KAKCCGKEHLIE------NEVSIL 443
Query: 82 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAV 141
R+V HP+II L++ E+++ +FLV +L++ G+LFD +T +E++ +++ +L A+
Sbjct: 444 RRVK-HPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANAL 502
Query: 142 SFLHANNIVHRDLKPENILL----DDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPE 197
+LH +IVHRD+KPEN+L+ D ++L DFG + +E L +CGTP Y+APE
Sbjct: 503 RYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE--GPLYTVCGTPTYVAPE 560
Query: 198 ILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL--MLRMIMEGQYQFSSP 255
I+ GYG +VD+WA GVI + LL G PPF + + I+ G+ +F +P
Sbjct: 561 II------AETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAP 614
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPF 290
WD+ + + K+LIS++LQV+ EAR TA Q L HP+
Sbjct: 615 YWDNITDSAKELISQMLQVNVEARCTAGQILSHPW 649
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 191 bits (485), Expect = 1e-48
Identities = 110/275 (40%), Positives = 169/275 (61%), Gaps = 22/275 (8%)
Query: 22 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 81
+KY VIG G +VV+ C+ R+TG EFA+KI++ A+ E L E E IL
Sbjct: 392 EKYKIGKVIGDGNFAVVKECIDRSTGKEFALKIID-KAKCCGKEHLIE------NEVSIL 444
Query: 82 RQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAV 141
R+V HP+II L++ E+++ +FLV +L++ G+LFD +T +E++ +++ +L A+
Sbjct: 445 RRVK-HPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANAL 503
Query: 142 SFLHANNIVHRDLKPENILL----DDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPE 197
+LH +IVHRD+KPEN+L+ D ++L DFG + +E L +CGTP Y+APE
Sbjct: 504 RYLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLATVVE--GPLYTVCGTPTYVAPE 561
Query: 198 ILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQIL--MLRMIMEGQYQFSSP 255
I+ GYG +VD+WA GVI + LL G PPF + + I+ G+ +F +P
Sbjct: 562 II------AETGYGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAP 615
Query: 256 EWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPF 290
WD+ + + K+LIS++LQV+ EAR TA Q L HP+
Sbjct: 616 YWDNITDSAKELISQMLQVNVEARCTAGQILSHPW 650
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 190 bits (483), Expect = 2e-48
Identities = 112/289 (38%), Positives = 161/289 (55%), Gaps = 20/289 (6%)
Query: 8 EDELPDWAAAKEFYQK-YDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQ 66
ED+ W +K + +V+G G S V R TG FA+K + + SP
Sbjct: 6 EDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCI-----KKSPAF 60
Query: 67 LEEVREATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALS 126
+ E E +L+++ H +I+TL D YES++ +LV L+ GELFD + E+ +
Sbjct: 61 RDSSLE---NEIAVLKKIK-HENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYT 116
Query: 127 EKETRSIMRSLLEAVSFLHANNIVHRDLKPENILL---DDNMQIRLSDFGFSCHLEPGEK 183
EK+ +++ +L AV +LH N IVHRDLKPEN+L ++N +I ++DFG S +E
Sbjct: 117 EKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLS-KMEQNGI 175
Query: 184 LRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLR 243
+ CGTPGY+APE+L Y K VD W+ GVI + LL G PPF+ + +
Sbjct: 176 MSTACGTPGYVAPEVL------AQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFE 229
Query: 244 MIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQHPFFE 292
I EG Y+F SP WDD S + KD I LL+ DP R T E+AL HP+ +
Sbjct: 230 KIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWID 278
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,568,184
Number of Sequences: 37866
Number of extensions: 750985
Number of successful extensions: 4142
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 760
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 1689
Number of HSP's gapped (non-prelim): 1025
length of query: 406
length of database: 18,247,518
effective HSP length: 105
effective length of query: 301
effective length of database: 14,271,588
effective search space: 4295747988
effective search space used: 4295747988
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.