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Search of human proteins with 4505569
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
(493 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens] 1004 0.0
gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo sapi... 401 e-112
gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo sapi... 397 e-110
gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens] 379 e-105
gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens] 362 e-100
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 304 1e-82
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 304 1e-82
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 231 9e-61
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 229 4e-60
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 226 5e-59
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 224 2e-58
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 217 2e-56
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 196 3e-50
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 196 4e-50
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 196 4e-50
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 195 7e-50
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 195 7e-50
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 193 3e-49
gi|11496279 male germ cell-associated kinase [Homo sapiens] 191 1e-48
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 190 2e-48
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 189 5e-48
gi|27477122 intestinal cell kinase [Homo sapiens] 187 2e-47
gi|7662388 intestinal cell kinase [Homo sapiens] 187 2e-47
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 187 2e-47
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 187 2e-47
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 186 5e-47
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 184 2e-46
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens] 184 2e-46
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 180 3e-45
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 180 3e-45
>gi|4505569 cyclin-dependent kinase-like 2 [Homo sapiens]
Length = 493
Score = 1004 bits (2597), Expect = 0.0
Identities = 493/493 (100%), Positives = 493/493 (100%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH
Sbjct: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH
Sbjct: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG
Sbjct: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
Query: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL
Sbjct: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
Query: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL 300
PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL
Sbjct: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL 300
Query: 301 QLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSK 360
QLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSK
Sbjct: 301 QLKVQKDARNVSLSKKSQNRKKEKEKDDSLVEERKTLVVQDTNADPKIKDYKLFKIKGSK 360
Query: 361 IDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLS 420
IDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLS
Sbjct: 361 IDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLTHNLS 420
Query: 421 AVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSD 480
AVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSD
Sbjct: 421 AVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPNRHSPSGIYNINVTTLVSGPPLSD 480
Query: 481 DSGADLPQMEHQH 493
DSGADLPQMEHQH
Sbjct: 481 DSGADLPQMEHQH 493
>gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
sapiens]
Length = 592
Score = 401 bits (1031), Expect = e-112
Identities = 215/480 (44%), Positives = 305/480 (63%), Gaps = 27/480 (5%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
ME YE LG VGEGSYG VMKC++K+TG+IVAIK F E + V KIAMREIK LKQ H
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQS-VNKIAMREIKFLKQFHH 59
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
ENLVNL+EV ++KK+ +LVFEF+DHT+LD+L+ + +GL+ + ++KYLFQI+ I + HS+
Sbjct: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
NIIHRDIKPENILVSQSG+ KLCDFGFARTLAAPG++YTDYVATRWYRAPEL++ D YG
Sbjct: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYG 179
Query: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
K VD+WA+GC++ EM G P P SD+D L+ I++ +GNL P Q +F+K+P+FAGV L
Sbjct: 180 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 239
Query: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL 300
P+++ + ++YPKL+ ++ D+ CL IDP R ++LLHH++F DGF E+F EL
Sbjct: 240 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPEL 299
Query: 301 QLKVQKDARNVSLSK-KSQNRKKEKEKDDSLVEERKTLVVQ-------DTNADPKIKDYK 352
+ K+ ++A+ SL K K +++ E KD+ TL+ + PK +
Sbjct: 300 KAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVR 359
Query: 353 LFKIKGSKIDGEKAEKGNRASNASCLHDSRTSH--------------NKIVPSTSLKDCS 398
+ K+KG + D + +K + H N I PST +C+
Sbjct: 360 VIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPST---NCN 416
Query: 399 NVSVDHTRNPSVAIPPLT-HNLSAVAPSINSGMGTETIPIQGYRVDEKTKKCSIPFVKPN 457
+ + SV +PP+ N + +A +++S + ++ + +T SI V PN
Sbjct: 417 GLKENPHCGGSVTMPPINLTNSNLMAANLSSNLFHPSVRLTERAKKRRTSSQSIGQVMPN 476
>gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo
sapiens]
Length = 455
Score = 397 bits (1019), Expect = e-110
Identities = 209/453 (46%), Positives = 295/453 (65%), Gaps = 27/453 (5%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
ME YE LG VGEGSYG VMKC++K+TG+IVAIK F E + V KIAMREIK LKQ H
Sbjct: 1 MEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQS-VNKIAMREIKFLKQFHH 59
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
ENLVNL+EV ++KK+ +LVFEF+DHT+LD+L+ + +GL+ + ++KYLFQI+ I + HS+
Sbjct: 60 ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSN 119
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
NIIHRDIKPENILVSQSG+ KLCDFGFARTLAAPG++YTDYVATRWYRAPEL++ D YG
Sbjct: 120 NIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYTDYVATRWYRAPELVLKDTSYG 179
Query: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
K VD+WA+GC++ EM G P P SD+D L+ I++ +GNL P Q +F+K+P+FAGV L
Sbjct: 180 KPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVL 239
Query: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL 300
P+++ + ++YPKL+ ++ D+ CL IDP R ++LLHH++F DGF E+F EL
Sbjct: 240 PQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDGFIEKFMPEL 299
Query: 301 QLKVQKDARNVSLSK-KSQNRKKEKEKDDSLVEERKTLVVQ-------DTNADPKIKDYK 352
+ K+ ++A+ SL K K +++ E KD+ TL+ + PK +
Sbjct: 300 KAKLLQEAKVNSLIKPKESSKENELRKDERKTVYTNTLLSSSVLGKEIEKEKKPKEIKVR 359
Query: 353 LFKIKGSKIDGEKAEKGNRASNASCLHDSRTSH--------------NKIVPSTSLKDCS 398
+ K+KG + D + +K + H N I PST +C+
Sbjct: 360 VIKVKGGRGDISEPKKKEYEGGLGQQDANENVHPMSPDTKLVTIEPPNPINPST---NCN 416
Query: 399 NVSVDHTRNPSVAIPPLT-HNLSAVAPSINSGM 430
+ + SV +PP+ N + +A +++S +
Sbjct: 417 GLKENPHCGGSVTMPPINLTNSNLMAANLSSNL 449
>gi|37596297 cyclin-dependent kinase-like 1 [Homo sapiens]
Length = 358
Score = 379 bits (973), Expect = e-105
Identities = 172/309 (55%), Positives = 233/309 (75%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
MEKYE +G +GEGSYG+V KCRN+DTG+IVAIKKFLES+DD ++KKIA+REI++LKQL+H
Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH 61
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
NLVNLLEV ++K+R +LVFE+ DHT+L +L+ + G+ +V+ +Q + + FCH H
Sbjct: 62 PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKH 121
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
N IHRD+KPENIL+++ V+KLCDFGFAR L P + YTDYVATRWYR+PELLVGD +YG
Sbjct: 122 NCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDYVATRWYRSPELLVGDTQYG 181
Query: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
VDVWAIGC+ E+ G PL+PG SD+DQLY I LG+LIPRHQ++F+ N F+GV++
Sbjct: 182 PPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKI 241
Query: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL 300
P+ ++ EPLE ++P +S + L K CLH+DP +R C +LLHH +F+ E ++E
Sbjct: 242 PDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEH 301
Query: 301 QLKVQKDAR 309
+K R
Sbjct: 302 NKPTRKTLR 310
>gi|57222269 cyclin-dependent kinase-like 4 [Homo sapiens]
Length = 315
Score = 362 bits (930), Expect = e-100
Identities = 171/318 (53%), Positives = 236/318 (74%), Gaps = 10/318 (3%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
MEKYE L GEGSYG+V KCRNK +G++VA+KKF+ES+DD +VKKIA+REI++LKQL+H
Sbjct: 1 MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKH 60
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
NLVNL+EV ++K++ +LVFE+ DHT+L++LE PNG+ V++ L+Q + + FCH H
Sbjct: 61 PNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIH 120
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
N IHRDIKPENIL+++ G++K+CDFGFA+ L PG+ YTDYVATRWYRAPELLVGD +YG
Sbjct: 121 NCIHRDIKPENILITKQGIIKICDFGFAQIL-IPGDAYTDYVATRWYRAPELLVGDTQYG 179
Query: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
+VD+WAIGC+ E+ G+PL+PG SD+DQLY I+ LG LIPRHQ +F N F G+ +
Sbjct: 180 SSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISI 239
Query: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQEL 300
PE ++ E LE ++ + V ++ K CL ++PD R C++LL +F D F QE
Sbjct: 240 PEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYF--DSF-----QEA 292
Query: 301 QLKVQKDARNVSLSKKSQ 318
Q+K + ARN +++ Q
Sbjct: 293 QIK--RKARNEGRNRRRQ 308
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 304 bits (778), Expect = 1e-82
Identities = 171/437 (39%), Positives = 266/437 (60%), Gaps = 18/437 (4%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
M K+E LG+VGEG+YG+V+KCR+K+T IVAIKKF +S++++ VK+ +RE+K+L+ L+
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
EN+V L E +++ + YLVFE+V+ +L+ LE PNG+ + V+ Y++Q+I I +CH +
Sbjct: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAPELLVGDVKY 179
+I+HRDIKPEN+L+S + V+KLCDFGFAR L+ YT+YVATRWYR+PELL+G Y
Sbjct: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APY 188
Query: 180 GKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVR 239
GK+VD+W++GC++ E+ G+PLFPG+S+IDQL+ I LG L +LF NP F G+R
Sbjct: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
Query: 240 LPEIKEREPLERRY-PKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQ 298
P + + LERRY L+ V++DL K L +DP R + L+H FQ +R
Sbjct: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
Query: 299 ELQLKVQKDARNVSLSKKSQNRKKE--KEKDDSLVEERKTLVVQDTNADPKIKDYKLFKI 356
+ + +LS ++Q K + S ++ + L V AD + + F
Sbjct: 309 RSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESF-- 366
Query: 357 KGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLT 416
++G A ++ S LH ++T P ++ KD +N ++ H +P A
Sbjct: 367 ----LNGNLA-----GASLSPLH-TKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTE 416
Query: 417 HNLSAVAPSINSGMGTE 433
+ + + P + G GT+
Sbjct: 417 FDFN-IDPKPSEGPGTK 432
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 304 bits (778), Expect = 1e-82
Identities = 171/437 (39%), Positives = 266/437 (60%), Gaps = 18/437 (4%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
M K+E LG+VGEG+YG+V+KCR+K+T IVAIKKF +S++++ VK+ +RE+K+L+ L+
Sbjct: 10 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 69
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
EN+V L E +++ + YLVFE+V+ +L+ LE PNG+ + V+ Y++Q+I I +CH +
Sbjct: 70 ENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKN 129
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YTDYVATRWYRAPELLVGDVKY 179
+I+HRDIKPEN+L+S + V+KLCDFGFAR L+ YT+YVATRWYR+PELL+G Y
Sbjct: 130 DIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLG-APY 188
Query: 180 GKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVR 239
GK+VD+W++GC++ E+ G+PLFPG+S+IDQL+ I LG L +LF NP F G+R
Sbjct: 189 GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLR 248
Query: 240 LPEIKEREPLERRY-PKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQ 298
P + + LERRY L+ V++DL K L +DP R + L+H FQ +R
Sbjct: 249 FPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
Query: 299 ELQLKVQKDARNVSLSKKSQNRKKE--KEKDDSLVEERKTLVVQDTNADPKIKDYKLFKI 356
+ + +LS ++Q K + S ++ + L V AD + + F
Sbjct: 309 RSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKDIQNLSVGLPRADEGLPANESF-- 366
Query: 357 KGSKIDGEKAEKGNRASNASCLHDSRTSHNKIVPSTSLKDCSNVSVDHTRNPSVAIPPLT 416
++G A ++ S LH ++T P ++ KD +N ++ H +P A
Sbjct: 367 ----LNGNLA-----GASLSPLH-TKTYQASSQPGSTSKDLTNNNIPHLLSPKEAKSKTE 416
Query: 417 HNLSAVAPSINSGMGTE 433
+ + + P + G GT+
Sbjct: 417 FDFN-IDPKPSEGPGTK 432
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 231 bits (590), Expect = 9e-61
Identities = 121/296 (40%), Positives = 171/296 (57%), Gaps = 17/296 (5%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
ME ++ + +GEG+YG+V K RNK TG +VA+KK + + V A+REI LLK+L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFP-NGLDYQVVQKYLFQIINGIGFCHS 119
N+V LL+V + + YLVFEF+ + ++ G+ +++ YLFQ++ G+ FCHS
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 120 HNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKY 179
H ++HRD+KP+N+L++ G +KL DFG AR P YT V T WYRAPE+L+G Y
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
Query: 180 GKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV- 238
AVD+W++GC+ EM LFPGDS+IDQL+ I LG V+ GV
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGT---------PDEVVWPGVT 231
Query: 239 RLPEIK------EREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288
+P+ K R+ + P L E L + LH DP+KR L H FFQ
Sbjct: 232 SMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 287
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 229 bits (584), Expect = 4e-60
Identities = 119/295 (40%), Positives = 175/295 (59%), Gaps = 17/295 (5%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
M+ ++ + +GEG+YG+V K +N++TG++VA+KK + + V A+REI LLK+L+H
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNG-LDYQVVQKYLFQIINGIGFCHS 119
N+V LL+V +++ YLVFEF+ + ++ P L +++ YLFQ++ G+ FCHS
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120
Query: 120 HNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKY 179
H +IHRD+KP+N+L+++ G +KL DFG AR P YT V T WYRAPE+L+G Y
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180
Query: 180 GKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV- 238
AVD+W+IGC+ EM + LFPGDS+IDQL+ I LG + GV
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGT---------PSEDTWPGVT 231
Query: 239 RLPEIK------EREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 287
+LP+ K R+ LE P L DL + L DP +R L H +F
Sbjct: 232 QLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 226 bits (575), Expect = 5e-59
Identities = 121/301 (40%), Positives = 174/301 (57%), Gaps = 28/301 (9%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
ME Y + +GEG+YG+V K R+K TG++VA+KK +++ V A+REI LLK+LRH
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNG--LDYQVVQKYLFQIINGIGFCH 118
N+V+L +V + R YL+FEF+ + L+ P G +D +V+ YL+QI+ GI FCH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 119 SHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVK 178
S ++HRD+KP+N+L+ G +KL DFG AR P VYT V T WYR+PE+L+G +
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180
Query: 179 YGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV 238
Y VD+W+IG + E+ +PLF GDS+IDQL+ I LG N V+
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT---------PNNEVW--- 228
Query: 239 RLPEIKEREPLERRYPK------------LSEVVIDLAKKCLHIDPDKRPFCAELLHHDF 286
PE++ + + +PK L E +DL K L DP KR L+H +
Sbjct: 229 --PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286
Query: 287 F 287
F
Sbjct: 287 F 287
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 224 bits (570), Expect = 2e-58
Identities = 120/301 (39%), Positives = 173/301 (57%), Gaps = 28/301 (9%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
ME Y + +GEG+YG+V K R+K TG++VA+KK +++ V A+REI LLK+LRH
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNG--LDYQVVQKYLFQIINGIGFCH 118
N+V+L +V + R YL+FEF+ + L+ P G +D +V+ YL+QI+ GI FCH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 119 SHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVK 178
S ++HRD+KP+N+L+ G +KL DFG AR P VYT T WYR+PE+L+G +
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSAR 180
Query: 179 YGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV 238
Y VD+W+IG + E+ +PLF GDS+IDQL+ I LG N V+
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGT---------PNNEVW--- 228
Query: 239 RLPEIKEREPLERRYPK------------LSEVVIDLAKKCLHIDPDKRPFCAELLHHDF 286
PE++ + + +PK L E +DL K L DP KR L+H +
Sbjct: 229 --PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286
Query: 287 F 287
F
Sbjct: 287 F 287
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 217 bits (553), Expect = 2e-56
Identities = 114/288 (39%), Positives = 165/288 (57%), Gaps = 3/288 (1%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
M+KYE L +GEG+YG V K +N++T IVA+K+ DDD+ V A+REI LLK+L+H
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
+N+V L +V K+ LVFEF D + + LD ++V+ +LFQ++ G+GFCHS
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
N++HRD+KP+N+L++++G +KL DFG AR P Y+ V T WYR P++L G Y
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
Query: 181 KAVDVWAIGCLVTEMF-MGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVR 239
++D+W+ GC+ E+ G PLFPG+ DQL I LG K P +
Sbjct: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK--P 238
Query: 240 LPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 287
P L PKL+ DL + L +P +R E L H +F
Sbjct: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 196 bits (499), Expect = 3e-50
Identities = 110/333 (33%), Positives = 178/333 (53%), Gaps = 11/333 (3%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
ME Y L +GEG+Y V K R+K T +VA+K+ + + ++ A+RE+ LLK L+H
Sbjct: 189 METYIKLEKLGEGTYATVYKGRSKLTENLVALKE-IRLEHEEGAPCTAIREVSLLKDLKH 247
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
N+V L ++ K LVFE++D + ++ N + V+ +L+QI+ G+ +CH
Sbjct: 248 ANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCHRR 307
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
++HRD+KP+N+L+++ G +KL DFG AR + P + Y++ V T WYR P++L+G +Y
Sbjct: 308 KVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSEYS 367
Query: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
+D+W +GC+ EM G PLFPG + D+L+ I LG + N F
Sbjct: 368 TQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNF 427
Query: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDG-----FAER 295
P+ K +PL P+L I+L K L + KR E + H +F+ G E
Sbjct: 428 PKYKP-QPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHALPES 486
Query: 296 FS----QELQLKVQKDARNVSLSKKSQNRKKEK 324
S +E+QL+ RN S + + + +
Sbjct: 487 VSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQ 519
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 196 bits (498), Expect = 4e-50
Identities = 106/299 (35%), Positives = 171/299 (57%), Gaps = 12/299 (4%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
++K++ +G++GEG+YG V K ++KDTG +VA+KK ++ + A+REIK+L+QL H
Sbjct: 724 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783
Query: 61 ENLVNLLEVC----------KKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQI 110
++VN+ E+ K K +YLVFE++DH ++ LE ++ ++ Q+
Sbjct: 784 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 843
Query: 111 INGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTL-AAPGEVYTDYVATRWYRA 169
+ G+ +CH N +HRDIK NIL++ SG +KL DFG AR + YT+ V T WYR
Sbjct: 844 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 903
Query: 170 PELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELF 229
PELL+G+ +Y A+DVW+ GC++ E+F +P+F + ++ QL I G+ P
Sbjct: 904 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDV 963
Query: 230 NKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288
K P F ++ P+ + R L + + +DL L +DP KR + L DF +
Sbjct: 964 IKLPYFNTMK-PKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK 1021
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 196 bits (498), Expect = 4e-50
Identities = 106/299 (35%), Positives = 171/299 (57%), Gaps = 12/299 (4%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
++K++ +G++GEG+YG V K ++KDTG +VA+KK ++ + A+REIK+L+QL H
Sbjct: 724 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIH 783
Query: 61 ENLVNLLEVC----------KKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQI 110
++VN+ E+ K K +YLVFE++DH ++ LE ++ ++ Q+
Sbjct: 784 RSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQL 843
Query: 111 INGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTL-AAPGEVYTDYVATRWYRA 169
+ G+ +CH N +HRDIK NIL++ SG +KL DFG AR + YT+ V T WYR
Sbjct: 844 MEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRP 903
Query: 170 PELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELF 229
PELL+G+ +Y A+DVW+ GC++ E+F +P+F + ++ QL I G+ P
Sbjct: 904 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDV 963
Query: 230 NKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288
K P F ++ P+ + R L + + +DL L +DP KR + L DF +
Sbjct: 964 IKLPYFNTMK-PKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLK 1021
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 195 bits (496), Expect = 7e-50
Identities = 104/299 (34%), Positives = 173/299 (57%), Gaps = 12/299 (4%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
++K++ +G++GEG+YG V K R+KDTG +VA+KK ++ + A+REIK+L+QL H
Sbjct: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
Query: 61 ENLVNLLEVC----------KKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQI 110
++++N+ E+ K K +YLVFE++DH ++ LE + ++ ++ Q+
Sbjct: 762 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 821
Query: 111 INGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAA-PGEVYTDYVATRWYRA 169
+ G+ +CH N +HRDIK NIL++ G +KL DFG AR ++ YT+ V T WYR
Sbjct: 822 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRP 881
Query: 170 PELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELF 229
PELL+G+ +Y A+DVW+ GC++ E+F +P+F + ++ QL I G+ P
Sbjct: 882 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDV 941
Query: 230 NKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288
K P F ++ P+ + R L + + +DL L +DP KR + L +F +
Sbjct: 942 IKLPYFNTMK-PKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR 999
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 195 bits (496), Expect = 7e-50
Identities = 104/299 (34%), Positives = 173/299 (57%), Gaps = 12/299 (4%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
++K++ +G++GEG+YG V K R+KDTG +VA+KK ++ + A+REIK+L+QL H
Sbjct: 702 VDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTH 761
Query: 61 ENLVNLLEVC----------KKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQI 110
++++N+ E+ K K +YLVFE++DH ++ LE + ++ ++ Q+
Sbjct: 762 QSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQL 821
Query: 111 INGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAA-PGEVYTDYVATRWYRA 169
+ G+ +CH N +HRDIK NIL++ G +KL DFG AR ++ YT+ V T WYR
Sbjct: 822 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRP 881
Query: 170 PELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELF 229
PELL+G+ +Y A+DVW+ GC++ E+F +P+F + ++ QL I G+ P
Sbjct: 882 PELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDV 941
Query: 230 NKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288
K P F ++ P+ + R L + + +DL L +DP KR + L +F +
Sbjct: 942 IKLPYFNTMK-PKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR 999
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 193 bits (490), Expect = 3e-49
Identities = 107/289 (37%), Positives = 169/289 (58%), Gaps = 3/289 (1%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR- 59
M++Y LG +GEG++G+V K ++ +TG IVA+KK + A+REIK L+++
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 60 HENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHS 119
++ +V L V + L FEF+ + + + L V+ YL ++ G+ FCH+
Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120
Query: 120 HNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGE-VYTDYVATRWYRAPELLVGDVK 178
+NI+HRD+KP N+L+S SG +K+ DFG AR + G +YT VATRWYRAPELL G +
Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ 180
Query: 179 YGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGV 238
Y + VD+W++GC++ E+ G PLFPG +DI+QL +++ LG P+ + P + +
Sbjct: 181 YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 240
Query: 239 RLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 287
E + PLE P +S +DL + L P +R ++ L H +F
Sbjct: 241 SFKE-QVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 288
>gi|11496279 male germ cell-associated kinase [Homo sapiens]
Length = 623
Score = 191 bits (486), Expect = 1e-48
Identities = 117/343 (34%), Positives = 185/343 (53%), Gaps = 36/343 (10%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIK----KFLESDDDKMVKKIAMREIKLLK 56
M +Y + +G+G+YG V+ ++ ++G +VAIK KF D+ + +RE+K LK
Sbjct: 1 MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDEC-----MNLREVKSLK 55
Query: 57 QLRHENLVNLLEVCKKKKRWYLVFEFVDHTIL----DDLELFPNGLDYQVVQKYLFQIIN 112
+L H N++ L EV ++ Y +FE++ + D +LFP V++ ++QI+
Sbjct: 56 KLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPES----VIRNIMYQILQ 111
Query: 113 GIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPEL 172
G+ F H H HRD+KPEN+L +VK+ DFG AR L + YTDYV+TRWYRAPE+
Sbjct: 112 GLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPP-YTDYVSTRWYRAPEV 170
Query: 173 LVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKN 232
L+ Y +DVWA+G ++ E++M PLFPG S++D+++ I LG P+ +
Sbjct: 171 LLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGT--PKKSDWPEGY 228
Query: 233 PVFAGV--RLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMD 290
+ + + R P+ L+ P S I L + L+ DP KRP ++ L H +FQ+
Sbjct: 229 QLASSMNFRFPQCVPIN-LKTLIPNASNEAIQLMTEMLNWDPKKRPTASQALKHPYFQVG 287
Query: 291 GFAERFSQELQLKVQKDARNVSLSKKSQNRKKEK-EKDDSLVE 332
S L+ SK+S N++ + E SLVE
Sbjct: 288 QVLGPSSNHLE------------SKQSLNKQLQPLESKPSLVE 318
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 190 bits (483), Expect = 2e-48
Identities = 107/308 (34%), Positives = 174/308 (56%), Gaps = 23/308 (7%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
+ KYE L +G+G++G V K R++ TG+ VA+KK L ++ + A+REIK+L+ L+H
Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKH 75
Query: 61 ENLVNLLEVCKKKK--------RWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIIN 112
EN+VNL+E+C+ K YLVF+F +H + L +++ + ++N
Sbjct: 76 ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLN 135
Query: 113 GIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLA----APGEVYTDYVATRWYR 168
G+ + H + I+HRD+K N+L+++ GV+KL DFG AR + + YT+ V T WYR
Sbjct: 136 GLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195
Query: 169 APELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPR---- 224
PELL+G+ YG +D+W GC++ EM+ P+ G+++ QL I G++ P
Sbjct: 196 PPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPN 255
Query: 225 --HQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELL 282
+ EL+ K + G + ++K+R R P +DL K L +DP +R + L
Sbjct: 256 VDNYELYEKLELVKGQK-RKVKDRLKAYVRDP----YALDLIDKLLVLDPAQRIDSDDAL 310
Query: 283 HHDFFQMD 290
+HDFF D
Sbjct: 311 NHDFFWSD 318
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 189 bits (480), Expect = 5e-48
Identities = 95/224 (42%), Positives = 138/224 (61%), Gaps = 9/224 (4%)
Query: 2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFL---ESDDDKMVKKIAMREIKLLKQL 58
++YE L +GEG + V K R+K+T +IVAIKK S+ + + A+REIKLL++L
Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69
Query: 59 RHENLVNLLEVCKKKKRWYLVFEFVD---HTILDDLELFPNGLDYQVVQKYLFQIINGIG 115
H N++ LL+ K LVF+F++ I+ D L L ++ Y+ + G+
Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV---LTPSHIKAYMLMTLQGLE 126
Query: 116 FCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVG 175
+ H H I+HRD+KP N+L+ ++GV+KL DFG A++ +P YT V TRWYRAPELL G
Sbjct: 127 YLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186
Query: 176 DVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLG 219
YG VD+WA+GC++ E+ + P PGDSD+DQL I LG
Sbjct: 187 ARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLG 230
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 187 bits (475), Expect = 2e-47
Identities = 104/307 (33%), Positives = 170/307 (55%), Gaps = 15/307 (4%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
M +Y + +G+G+YG V+ R+ ++G ++AIKK ++ + + +RE+K LK+L H
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKK-MKRKFYSWEECMNLREVKSLKKLNH 59
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLE----LFPNGLDYQVVQKYLFQIINGIGF 116
N+V L EV ++ Y +FE++ + ++ LFP ++ ++QI+ G+ F
Sbjct: 60 ANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPES----AIRNIMYQILQGLAF 115
Query: 117 CHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGD 176
H H HRD+KPEN+L +VK+ DFG AR + + YTDYV+TRWYRAPE+L+
Sbjct: 116 IHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPP-YTDYVSTRWYRAPEVLLRS 174
Query: 177 VKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFA 236
Y +DVWA+GC++ E++ PLFPG S+ID ++ I LG P+ + + +
Sbjct: 175 TNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGT--PKKTDWPEGYQLSS 232
Query: 237 GV--RLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAE 294
+ R P+ L+ P S + L + L DP KRP ++ L + +FQ+
Sbjct: 233 AMNFRWPQCVPNN-LKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLG 291
Query: 295 RFSQELQ 301
+Q LQ
Sbjct: 292 STTQNLQ 298
>gi|7662388 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 187 bits (475), Expect = 2e-47
Identities = 104/307 (33%), Positives = 170/307 (55%), Gaps = 15/307 (4%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
M +Y + +G+G+YG V+ R+ ++G ++AIKK ++ + + +RE+K LK+L H
Sbjct: 1 MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKK-MKRKFYSWEECMNLREVKSLKKLNH 59
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLE----LFPNGLDYQVVQKYLFQIINGIGF 116
N+V L EV ++ Y +FE++ + ++ LFP ++ ++QI+ G+ F
Sbjct: 60 ANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPES----AIRNIMYQILQGLAF 115
Query: 117 CHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGD 176
H H HRD+KPEN+L +VK+ DFG AR + + YTDYV+TRWYRAPE+L+
Sbjct: 116 IHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPP-YTDYVSTRWYRAPEVLLRS 174
Query: 177 VKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFA 236
Y +DVWA+GC++ E++ PLFPG S+ID ++ I LG P+ + + +
Sbjct: 175 TNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGT--PKKTDWPEGYQLSS 232
Query: 237 GV--RLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAE 294
+ R P+ L+ P S + L + L DP KRP ++ L + +FQ+
Sbjct: 233 AMNFRWPQCVPNN-LKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYFQVGHPLG 291
Query: 295 RFSQELQ 301
+Q LQ
Sbjct: 292 STTQNLQ 298
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 187 bits (475), Expect = 2e-47
Identities = 98/287 (34%), Positives = 158/287 (55%), Gaps = 2/287 (0%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
+E Y L +GEG+Y V K ++K T +VA+K+ + + ++ A+RE+ LLK L+H
Sbjct: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKE-IRLEHEEGAPCTAIREVSLLKDLKH 226
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
N+V L ++ +K LVFE++D + L+ N ++ V+ +LFQ++ G+ +CH
Sbjct: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 286
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
++HRD+KP+N+L+++ G +KL DFG AR + P + Y++ V T WYR P++L+G Y
Sbjct: 287 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYS 346
Query: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
+D+W +GC+ EM G PLFPG + +QL+ I LG N F
Sbjct: 347 TQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNY 406
Query: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 287
P+ + E L P+L DL K L + R + + H FF
Sbjct: 407 PKYR-AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 187 bits (475), Expect = 2e-47
Identities = 98/287 (34%), Positives = 158/287 (55%), Gaps = 2/287 (0%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
+E Y L +GEG+Y V K ++K T +VA+K+ + + ++ A+RE+ LLK L+H
Sbjct: 162 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKE-IRLEHEEGAPCTAIREVSLLKDLKH 220
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
N+V L ++ +K LVFE++D + L+ N ++ V+ +LFQ++ G+ +CH
Sbjct: 221 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 280
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
++HRD+KP+N+L+++ G +KL DFG AR + P + Y++ V T WYR P++L+G Y
Sbjct: 281 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYS 340
Query: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
+D+W +GC+ EM G PLFPG + +QL+ I LG N F
Sbjct: 341 TQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNY 400
Query: 241 PEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 287
P+ + E L P+L DL K L + R + + H FF
Sbjct: 401 PKYR-AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 446
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 186 bits (471), Expect = 5e-47
Identities = 105/289 (36%), Positives = 158/289 (54%), Gaps = 5/289 (1%)
Query: 2 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHE 61
+ YE L +GEGSY V K ++K G++VA+K + +++ A+RE LLK L+H
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALK-VIRLQEEEGTPFTAIREASLLKGLKHA 173
Query: 62 NLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHN 121
N+V L ++ K+ LVFE+V + ++ P GL V+ +LFQ++ G+ + H
Sbjct: 174 NIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRY 233
Query: 122 IIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGK 181
I+HRD+KP+N+L+S +G +KL DFG AR + P Y++ V T WYR P++L+G +Y
Sbjct: 234 ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYST 293
Query: 182 AVDVWAIGCLVTEMFMGEPLFPGDSDI-DQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
+D+W +GC+ EM G FPG DI DQL I + LG + P F R
Sbjct: 294 CLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERF 353
Query: 241 PEIKEREPLERRYPKLSEV--VIDLAKKCLHIDPDKRPFCAELLHHDFF 287
+ + L + + KLS V DLA K L P R L H++F
Sbjct: 354 -TLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYF 401
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 184 bits (466), Expect = 2e-46
Identities = 108/297 (36%), Positives = 167/297 (56%), Gaps = 16/297 (5%)
Query: 2 EKYENLGLVGEGSYGMVMKCRN-KDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR- 59
++YE + +GEG+YG V K R+ K+ GR VA+K+ ++ + +RE+ +L+ L
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 60 --HENLVNLLEVCK-----KKKRWYLVFEFVDHTILDDLELFPN-GLDYQVVQKYLFQII 111
H N+V L +VC ++ + LVFE VD + L+ P G+ + ++ +FQ++
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 112 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPE 171
G+ F HSH ++HRD+KP+NILV+ SG +KL DFG AR + T V T WYRAPE
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-MALTSVVVTLWYRAPE 189
Query: 172 LLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNK 231
+L+ Y VD+W++GC+ EMF +PLF G SD+DQL I+ +G +P ++
Sbjct: 190 VLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--LPGEEDW--P 244
Query: 232 NPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288
V + K +P+E+ + E+ DL KCL +P KR L H +FQ
Sbjct: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301
>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 184 bits (466), Expect = 2e-46
Identities = 108/297 (36%), Positives = 167/297 (56%), Gaps = 16/297 (5%)
Query: 2 EKYENLGLVGEGSYGMVMKCRN-KDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR- 59
++YE + +GEG+YG V K R+ K+ GR VA+K+ ++ + +RE+ +L+ L
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 60 --HENLVNLLEVCK-----KKKRWYLVFEFVDHTILDDLELFPN-GLDYQVVQKYLFQII 111
H N+V L +VC ++ + LVFE VD + L+ P G+ + ++ +FQ++
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 112 NGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPE 171
G+ F HSH ++HRD+KP+NILV+ SG +KL DFG AR + T V T WYRAPE
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQ-MALTSVVVTLWYRAPE 189
Query: 172 LLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNK 231
+L+ Y VD+W++GC+ EMF +PLF G SD+DQL I+ +G +P ++
Sbjct: 190 VLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIG--LPGEEDW--P 244
Query: 232 NPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 288
V + K +P+E+ + E+ DL KCL +P KR L H +FQ
Sbjct: 245 RDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 180 bits (456), Expect = 3e-45
Identities = 106/336 (31%), Positives = 178/336 (52%), Gaps = 15/336 (4%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
+E Y L +GEG+Y V K R+K T +VA+K+ + + ++ A+RE+ LLK L+H
Sbjct: 171 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKE-IRLEHEEGAPCTAIREVSLLKNLKH 229
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
N+V L ++ + LVFE++D + L+ N + V+ ++FQ++ G+ +CH
Sbjct: 230 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 289
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
I+HRD+KP+N+L+++ G +KL DFG AR + P + Y++ V T WYR P++L+G +Y
Sbjct: 290 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 349
Query: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
+D+W +GC+ EM G PLFPG + ++L+ I LG +E + F+ R
Sbjct: 350 TPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGT---PTEETWPGVTAFSEFRT 406
Query: 241 PEIK--EREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF--------QMD 290
+PL P+L I L L + R L H +F Q++
Sbjct: 407 YSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLE 466
Query: 291 GFAERFSQELQLKVQKDARNVSLSKKSQNRKKEKEK 326
A FS + ++++QKD L+ + R K + +
Sbjct: 467 DTASIFSLK-EIQLQKDPGYRGLAFQQPGRGKNRRQ 501
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 180 bits (456), Expect = 3e-45
Identities = 106/336 (31%), Positives = 178/336 (52%), Gaps = 15/336 (4%)
Query: 1 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 60
+E Y L +GEG+Y V K R+K T +VA+K+ + + ++ A+RE+ LLK L+H
Sbjct: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKE-IRLEHEEGAPCTAIREVSLLKNLKH 199
Query: 61 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSH 120
N+V L ++ + LVFE++D + L+ N + V+ ++FQ++ G+ +CH
Sbjct: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 259
Query: 121 NIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYG 180
I+HRD+KP+N+L+++ G +KL DFG AR + P + Y++ V T WYR P++L+G +Y
Sbjct: 260 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 319
Query: 181 KAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRL 240
+D+W +GC+ EM G PLFPG + ++L+ I LG +E + F+ R
Sbjct: 320 TPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGT---PTEETWPGVTAFSEFRT 376
Query: 241 PEIK--EREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF--------QMD 290
+PL P+L I L L + R L H +F Q++
Sbjct: 377 YSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLE 436
Query: 291 GFAERFSQELQLKVQKDARNVSLSKKSQNRKKEKEK 326
A FS + ++++QKD L+ + R K + +
Sbjct: 437 DTASIFSLK-EIQLQKDPGYRGLAFQQPGRGKNRRQ 471
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,385,233
Number of Sequences: 37866
Number of extensions: 904985
Number of successful extensions: 5787
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 733
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 3214
Number of HSP's gapped (non-prelim): 1153
length of query: 493
length of database: 18,247,518
effective HSP length: 106
effective length of query: 387
effective length of database: 14,233,722
effective search space: 5508450414
effective search space used: 5508450414
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.