Guide to the Human Genome
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Search of human proteins with 13027388

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13027388 STE20-related kinase adaptor beta [Homo sapiens]
         (418 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13027388 STE20-related kinase adaptor beta [Homo sapiens]          852   0.0  
gi|51242957 protein kinase LYK5 isoform 4 [Homo sapiens]              325   5e-89
gi|51242955 protein kinase LYK5 isoform 1 [Homo sapiens]              325   5e-89
gi|51242960 protein kinase LYK5 isoform 2 [Homo sapiens]              325   5e-89
gi|31982873 protein kinase LYK5 isoform 3 [Homo sapiens]              295   7e-80
gi|4826878 oxidative-stress responsive 1 [Homo sapiens]               146   4e-35
gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yea...   136   3e-32
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                 111   1e-24
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...   107   2e-23
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...   107   3e-23
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...   107   3e-23
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...   107   3e-23
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...   107   3e-23
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...   107   3e-23
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...   107   3e-23
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...   107   3e-23
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...   107   3e-23
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]      105   1e-22
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]       105   1e-22
gi|15451902 mitogen-activated protein kinase kinase kinase kinas...   104   1e-22
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...   104   2e-22
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...   104   2e-22
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...   104   2e-22
gi|110611908 mitogen-activated protein kinase kinase kinase kina...   101   1e-21
gi|6005810 mitogen-activated protein kinase kinase kinase kinase...   101   1e-21
gi|38570135 mitogen-activated protein kinase kinase kinase kinas...   101   1e-21
gi|14589909 mitogen-activated protein kinase kinase kinase kinas...   101   1e-21
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]     100   2e-21
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]     100   2e-21
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]     100   2e-21

>gi|13027388 STE20-related kinase adaptor beta [Homo sapiens]
          Length = 418

 Score =  852 bits (2202), Expect = 0.0
 Identities = 418/418 (100%), Positives = 418/418 (100%)

Query: 1   MSLLDCFCTSRTQVESLRPEKQSETSIHQYLVDEPTLSWSRPSTRASEVLCSTNVSHYEL 60
           MSLLDCFCTSRTQVESLRPEKQSETSIHQYLVDEPTLSWSRPSTRASEVLCSTNVSHYEL
Sbjct: 1   MSLLDCFCTSRTQVESLRPEKQSETSIHQYLVDEPTLSWSRPSTRASEVLCSTNVSHYEL 60

Query: 61  QVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNIT 120
           QVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNIT
Sbjct: 61  QVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNIT 120

Query: 121 TYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQNGC 180
           TYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQNGC
Sbjct: 121 TYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQNGC 180

Query: 181 IHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQ 240
           IHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQ
Sbjct: 181 IHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQ 240

Query: 241 DLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESR 300
           DLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESR
Sbjct: 241 DLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESR 300

Query: 301 MKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSA 360
           MKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSA
Sbjct: 301 MKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSA 360

Query: 361 SSLLSHVFFKQMKEESQDSILSLLPPAYNKPSISLPPVLPWTEPECDFPDEKDSYWEF 418
           SSLLSHVFFKQMKEESQDSILSLLPPAYNKPSISLPPVLPWTEPECDFPDEKDSYWEF
Sbjct: 361 SSLLSHVFFKQMKEESQDSILSLLPPAYNKPSISLPPVLPWTEPECDFPDEKDSYWEF 418


>gi|51242957 protein kinase LYK5 isoform 4 [Homo sapiens]
          Length = 373

 Score =  325 bits (833), Expect = 5e-89
 Identities = 168/329 (51%), Positives = 222/329 (67%), Gaps = 1/329 (0%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           YEL   IG+GF++L +V+LAR+ PTG  VT++  NLE C+ E +  LQ  + +S  F HP
Sbjct: 11  YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 70

Query: 118 NITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQ 177
           NI  Y   F   + LWV++ FMAYGSA  L+ T+F +GM+E  I  IL G ++ L+Y+H 
Sbjct: 71  NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 130

Query: 178 NGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPEL 237
            G +HRS+KASHILIS DG V LSGL    S++ HGQR R V+DFP++S  V PWLSPE+
Sbjct: 131 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 190

Query: 238 LRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQS 297
           L+Q+L GY+ KSDIYSVGITACELA+G VPF+DM  TQMLL+KL G     LD S  P  
Sbjct: 191 LQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAE 250

Query: 298 ESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKR 357
           E  M  S+S  +SG+ +S L +S     N D    P  +TFSP F   V+ CLQ++P+ R
Sbjct: 251 ELTMSPSRSVANSGLSDS-LTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 309

Query: 358 PSASSLLSHVFFKQMKEESQDSILSLLPP 386
           PSAS+LL+H FFKQ+K  + +++  LL P
Sbjct: 310 PSASTLLNHSFFKQIKRRASEALPELLRP 338


>gi|51242955 protein kinase LYK5 isoform 1 [Homo sapiens]
          Length = 431

 Score =  325 bits (833), Expect = 5e-89
 Identities = 168/329 (51%), Positives = 222/329 (67%), Gaps = 1/329 (0%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           YEL   IG+GF++L +V+LAR+ PTG  VT++  NLE C+ E +  LQ  + +S  F HP
Sbjct: 69  YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 128

Query: 118 NITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQ 177
           NI  Y   F   + LWV++ FMAYGSA  L+ T+F +GM+E  I  IL G ++ L+Y+H 
Sbjct: 129 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 188

Query: 178 NGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPEL 237
            G +HRS+KASHILIS DG V LSGL    S++ HGQR R V+DFP++S  V PWLSPE+
Sbjct: 189 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 248

Query: 238 LRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQS 297
           L+Q+L GY+ KSDIYSVGITACELA+G VPF+DM  TQMLL+KL G     LD S  P  
Sbjct: 249 LQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAE 308

Query: 298 ESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKR 357
           E  M  S+S  +SG+ +S L +S     N D    P  +TFSP F   V+ CLQ++P+ R
Sbjct: 309 ELTMSPSRSVANSGLSDS-LTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 367

Query: 358 PSASSLLSHVFFKQMKEESQDSILSLLPP 386
           PSAS+LL+H FFKQ+K  + +++  LL P
Sbjct: 368 PSASTLLNHSFFKQIKRRASEALPELLRP 396


>gi|51242960 protein kinase LYK5 isoform 2 [Homo sapiens]
          Length = 394

 Score =  325 bits (833), Expect = 5e-89
 Identities = 168/329 (51%), Positives = 222/329 (67%), Gaps = 1/329 (0%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           YEL   IG+GF++L +V+LAR+ PTG  VT++  NLE C+ E +  LQ  + +S  F HP
Sbjct: 32  YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91

Query: 118 NITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQ 177
           NI  Y   F   + LWV++ FMAYGSA  L+ T+F +GM+E  I  IL G ++ L+Y+H 
Sbjct: 92  NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151

Query: 178 NGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPEL 237
            G +HRS+KASHILIS DG V LSGL    S++ HGQR R V+DFP++S  V PWLSPE+
Sbjct: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211

Query: 238 LRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQS 297
           L+Q+L GY+ KSDIYSVGITACELA+G VPF+DM  TQMLL+KL G     LD S  P  
Sbjct: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAE 271

Query: 298 ESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKR 357
           E  M  S+S  +SG+ +S L +S     N D    P  +TFSP F   V+ CLQ++P+ R
Sbjct: 272 ELTMSPSRSVANSGLSDS-LTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 330

Query: 358 PSASSLLSHVFFKQMKEESQDSILSLLPP 386
           PSAS+LL+H FFKQ+K  + +++  LL P
Sbjct: 331 PSASTLLNHSFFKQIKRRASEALPELLRP 359


>gi|31982873 protein kinase LYK5 isoform 3 [Homo sapiens]
          Length = 348

 Score =  295 bits (754), Expect = 7e-80
 Identities = 153/300 (51%), Positives = 200/300 (66%), Gaps = 1/300 (0%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           YEL   IG+GF++L +V+LAR+ PTG  VT++  NLE C+ E +  LQ  + +S  F HP
Sbjct: 32  YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91

Query: 118 NITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQ 177
           NI  Y   F   + LWV++ FMAYGSA  L+ T+F +GM+E  I  IL G ++ L+Y+H 
Sbjct: 92  NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151

Query: 178 NGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPEL 237
            G +HRS+KASHILIS DG V LSGL    S++ HGQR R V+DFP++S  V PWLSPE+
Sbjct: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211

Query: 238 LRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQS 297
           L+Q+L GY+ KSDIYSVGITACELA+G VPF+DM  TQMLL+KL G     LD S  P  
Sbjct: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAE 271

Query: 298 ESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKR 357
           E  M  S+S  +SG+ +S L +S     N D    P  +TFSP F   V+ CLQ++P+ R
Sbjct: 272 ELTMSPSRSVANSGLSDS-LTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 330


>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
          Length = 527

 Score =  146 bits (368), Expect = 4e-35
 Identities = 108/353 (30%), Positives = 168/353 (47%), Gaps = 55/353 (15%)

Query: 43  STRASEVLCSTNVSHYELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLK 102
           S  +S +  S N   YELQ  IG G   +  V  A   P    V IK  NLE C     +
Sbjct: 2   SEDSSALPWSINRDDYELQEVIGSGATAV--VQAAYCAPKKEKVAIKRINLEKCQTSMDE 59

Query: 103 ALQKAVILSHFFRHPNITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEG------M 156
            L++   +S    HPNI +Y+T F V   LW++   ++ GS   +++    +G      +
Sbjct: 60  LLKEIQAMSQC-HHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVL 118

Query: 157 SETLIRNILFGAVRGLNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQ-- 214
            E+ I  IL   + GL YLH+NG IHR +KA +IL+  DG V ++       L   G   
Sbjct: 119 DESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDIT 178

Query: 215 RHRAVYDFPQFSTSVQPWLSPELLRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRT 274
           R++    F         W++PE++ Q + GY+ K+DI+S GITA ELA+G  P+      
Sbjct: 179 RNKVRKTF----VGTPCWMAPEVMEQ-VRGYDFKADIWSFGITAIELATGAAPYH----- 228

Query: 275 QMLLQKLKGPPYSPLDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPS 334
                  K PP   L +++        +N    +++G+ +  ++                
Sbjct: 229 -------KYPPMKVLMLTL--------QNDPPSLETGVQDKEML---------------- 257

Query: 335 SKTFSPAFFSLVQLCLQQDPEKRPSASSLLSHVFFKQMKEES--QDSILSLLP 385
            K +  +F  ++ LCLQ+DPEKRP+A+ LL H FF++ K +   Q+  L   P
Sbjct: 258 -KKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAP 309


>gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
           [Homo sapiens]
          Length = 545

 Score =  136 bits (343), Expect = 3e-32
 Identities = 98/324 (30%), Positives = 155/324 (47%), Gaps = 53/324 (16%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           YELQ  IG G   +    L +  P    V IK  NLE C     + L++   +S    HP
Sbjct: 63  YELQEVIGSGATAVVQAALCK--PRQERVAIKRINLEKCQTSMDELLKEIQAMSQC-SHP 119

Query: 118 NITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEG------MSETLIRNILFGAVRG 171
           N+ TY+T F V   LW++   ++ GS   +++     G      + E +I  IL   + G
Sbjct: 120 NVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEG 179

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQ--RHRAVYDFPQFSTSV 229
           L+YLH+NG IHR +KA +IL+  DG V ++       L   G   R++    F       
Sbjct: 180 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTF----VGT 235

Query: 230 QPWLSPELLRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPL 289
             W++PE++ Q + GY+ K+D++S GITA ELA+G  P+             K PP   L
Sbjct: 236 PCWMAPEVMEQ-VRGYDFKADMWSFGITAIELATGAAPYH------------KYPPMKVL 282

Query: 290 DISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLC 349
            +++        +N    +++G+ +  ++                 K +  +F  L+ LC
Sbjct: 283 MLTL--------QNDPPTLETGVEDKEMM-----------------KKYGKSFRKLLSLC 317

Query: 350 LQQDPEKRPSASSLLSHVFFKQMK 373
           LQ+DP KRP+A+ LL   FF++ K
Sbjct: 318 LQKDPSKRPTAAELLKCKFFQKAK 341


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score =  111 bits (277), Expect = 1e-24
 Identities = 96/328 (29%), Positives = 142/328 (43%), Gaps = 71/328 (21%)

Query: 63  EIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNITTY 122
           E+ +G DN T            +V IKI +LE   +E     Q+  +LS     P IT Y
Sbjct: 33  EVYKGIDNHTK----------EVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYITRY 81

Query: 123 WTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQNGCIH 182
           +  +   + LW+I  ++  GSA  LL+   P  + ET I  IL   ++GL+YLH    IH
Sbjct: 82  FGSYLKSTKLWIIMEYLGGGSALDLLK---PGPLEETYIATILREILKGLDYLHSERKIH 138

Query: 183 RSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQDL 242
           R IKA+++L+S  G V L+       L     +       P        W++PE+++Q  
Sbjct: 139 RDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF-------WMAPEVIKQS- 190

Query: 243 HGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESRMK 302
             Y+ K+DI+S+GITA ELA G+ P  D+H  ++L    K  P         P  E    
Sbjct: 191 -AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSP---------PTLE---- 236

Query: 303 NSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSASS 362
                             G H               S  F   V+ CL +DP  RP+A  
Sbjct: 237 ------------------GQH---------------SKPFKEFVEACLNKDPRFRPTAKE 263

Query: 363 LLSHVFFKQMKEESQDSILSLLPPAYNK 390
           LL H F  +  +++  S L+ L   Y +
Sbjct: 264 LLKHKFITRYTKKT--SFLTELIDRYKR 289


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score =  107 bits (267), Expect = 2e-23
 Identities = 93/323 (28%), Positives = 140/323 (43%), Gaps = 73/323 (22%)

Query: 63  EIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNITTY 122
           E+ +G DN T            +V IKI +LE   +E     Q+  +LS       +T Y
Sbjct: 37  EVFKGIDNRTQ----------QVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSSYVTKY 85

Query: 123 WTVFTVGSWLWVISPFMAYGSASQLLRTY-FPEGMSETLIRNILFGAVRGLNYLHQNGCI 181
           +  +  GS LW+I  ++  GSA  LLR   F E    T+++ IL    +GL+YLH    I
Sbjct: 86  YGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEIL----KGLDYLHSEKKI 141

Query: 182 HRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQD 241
           HR IKA+++L+S  G V L+       L     +       P        W++PE+++Q 
Sbjct: 142 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF-------WMAPEVIQQS 194

Query: 242 LHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESRM 301
              Y+ K+DI+S+GITA ELA G+ P  DMH  ++L    K  P                
Sbjct: 195 --AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNP---------------- 236

Query: 302 KNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSAS 361
                   + +G+                       F+ +F   +  CL +DP  RP+A 
Sbjct: 237 -------PTLVGD-----------------------FTKSFKEFIDACLNKDPSFRPTAK 266

Query: 362 SLLSHVFFKQMKEESQDSILSLL 384
            LL H F   +K   + S L+ L
Sbjct: 267 ELLKHKFI--VKNSKKTSYLTEL 287


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score =  107 bits (266), Expect = 3e-23
 Identities = 87/329 (26%), Positives = 137/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVELVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFT------VGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F       +   LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L++LHQ+  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ KSD++S+GITA E+A G  P  DMH  + L    + P    
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNP---- 249

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  F S ++ 
Sbjct: 250 ---------APRLK--------------------------------SKKWSKKFQSFIES 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RP+   L+ H F +    E Q
Sbjct: 269 CLVKNHSQRPATEQLMKHPFIRDQPNERQ 297


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
           sapiens]
          Length = 1276

 Score =  107 bits (266), Expect = 3e-23
 Identities = 87/329 (26%), Positives = 137/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVELVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFT------VGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F       +   LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L++LHQ+  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ KSD++S+GITA E+A G  P  DMH  + L    + P    
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNP---- 249

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  F S ++ 
Sbjct: 250 ---------APRLK--------------------------------SKKWSKKFQSFIES 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RP+   L+ H F +    E Q
Sbjct: 269 CLVKNHSQRPATEQLMKHPFIRDQPNERQ 297


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
           sapiens]
          Length = 1297

 Score =  107 bits (266), Expect = 3e-23
 Identities = 87/329 (26%), Positives = 137/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVELVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFT------VGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F       +   LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L++LHQ+  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ KSD++S+GITA E+A G  P  DMH  + L    + P    
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNP---- 249

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  F S ++ 
Sbjct: 250 ---------APRLK--------------------------------SKKWSKKFQSFIES 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RP+   L+ H F +    E Q
Sbjct: 269 CLVKNHSQRPATEQLMKHPFIRDQPNERQ 297


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
           sapiens]
          Length = 1305

 Score =  107 bits (266), Expect = 3e-23
 Identities = 87/329 (26%), Positives = 137/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVELVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFT------VGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F       +   LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L++LHQ+  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ KSD++S+GITA E+A G  P  DMH  + L    + P    
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNP---- 249

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  F S ++ 
Sbjct: 250 ---------APRLK--------------------------------SKKWSKKFQSFIES 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RP+   L+ H F +    E Q
Sbjct: 269 CLVKNHSQRPATEQLMKHPFIRDQPNERQ 297


>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
           sapiens]
          Length = 1323

 Score =  107 bits (266), Expect = 3e-23
 Identities = 87/329 (26%), Positives = 137/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVELVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFT------VGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F       +   LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L++LHQ+  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ KSD++S+GITA E+A G  P  DMH  + L    + P    
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNP---- 249

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  F S ++ 
Sbjct: 250 ---------APRLK--------------------------------SKKWSKKFQSFIES 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RP+   L+ H F +    E Q
Sbjct: 269 CLVKNHSQRPATEQLMKHPFIRDQPNERQ 297


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
           sapiens]
          Length = 1331

 Score =  107 bits (266), Expect = 3e-23
 Identities = 87/329 (26%), Positives = 137/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVELVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFT------VGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F       +   LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L++LHQ+  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ KSD++S+GITA E+A G  P  DMH  + L    + P    
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNP---- 249

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  F S ++ 
Sbjct: 250 ---------APRLK--------------------------------SKKWSKKFQSFIES 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RP+   L+ H F +    E Q
Sbjct: 269 CLVKNHSQRPATEQLMKHPFIRDQPNERQ 297


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
           sapiens]
          Length = 1352

 Score =  107 bits (266), Expect = 3e-23
 Identities = 87/329 (26%), Positives = 137/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVELVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFT------VGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F       +   LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L++LHQ+  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ KSD++S+GITA E+A G  P  DMH  + L    + P    
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNP---- 249

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  F S ++ 
Sbjct: 250 ---------APRLK--------------------------------SKKWSKKFQSFIES 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RP+   L+ H F +    E Q
Sbjct: 269 CLVKNHSQRPATEQLMKHPFIRDQPNERQ 297


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
           sapiens]
          Length = 1360

 Score =  107 bits (266), Expect = 3e-23
 Identities = 87/329 (26%), Positives = 137/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVELVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFT------VGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F       +   LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L++LHQ+  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ KSD++S+GITA E+A G  P  DMH  + L    + P    
Sbjct: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNP---- 249

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  F S ++ 
Sbjct: 250 ---------APRLK--------------------------------SKKWSKKFQSFIES 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RP+   L+ H F +    E Q
Sbjct: 269 CLVKNHSQRPATEQLMKHPFIRDQPNERQ 297


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score =  105 bits (261), Expect = 1e-22
 Identities = 90/328 (27%), Positives = 138/328 (42%), Gaps = 71/328 (21%)

Query: 63  EIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNITTY 122
           E+ +G DN T            +V IKI +LE   +E     Q+  +LS     P +T Y
Sbjct: 37  EVFKGIDNRTQ----------KVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYVTKY 85

Query: 123 WTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQNGCIH 182
           +  +   + LW+I  ++  GSA  LL    P  + ET I  IL   ++GL+YLH    IH
Sbjct: 86  YGSYLKDTKLWIIMEYLGGGSALDLLE---PGPLDETQIATILREILKGLDYLHSEKKIH 142

Query: 183 RSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQDL 242
           R IKA+++L+S  G V L+       L     +       P        W++PE+++Q  
Sbjct: 143 RDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPF-------WMAPEVIKQS- 194

Query: 243 HGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESRMK 302
             Y+ K+DI+S+GITA ELA G+ P  ++H  ++L    K  P         P  E    
Sbjct: 195 -AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNP---------PTLEG--- 241

Query: 303 NSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSASS 362
                                              +S      V+ CL ++P  RP+A  
Sbjct: 242 ----------------------------------NYSKPLKEFVEACLNKEPSFRPTAKE 267

Query: 363 LLSHVFFKQMKEESQDSILSLLPPAYNK 390
           LL H F   ++   + S L+ L   Y +
Sbjct: 268 LLKHKFI--LRNAKKTSYLTELIDRYKR 293


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score =  105 bits (261), Expect = 1e-22
 Identities = 90/328 (27%), Positives = 138/328 (42%), Gaps = 71/328 (21%)

Query: 63  EIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNITTY 122
           E+ +G DN T            +V IKI +LE   +E     Q+  +LS     P +T Y
Sbjct: 49  EVFKGIDNRTQ----------KVVAIKIIDLEEAEDEIEDIQQEITVLSQC-DSPYVTKY 97

Query: 123 WTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQNGCIH 182
           +  +   + LW+I  ++  GSA  LL    P  + ET I  IL   ++GL+YLH    IH
Sbjct: 98  YGSYLKDTKLWIIMEYLGGGSALDLLE---PGPLDETQIATILREILKGLDYLHSEKKIH 154

Query: 183 RSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQDL 242
           R IKA+++L+S  G V L+       L     +       P        W++PE+++Q  
Sbjct: 155 RDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPF-------WMAPEVIKQS- 206

Query: 243 HGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESRMK 302
             Y+ K+DI+S+GITA ELA G+ P  ++H  ++L    K  P         P  E    
Sbjct: 207 -AYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNP---------PTLEG--- 253

Query: 303 NSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSASS 362
                                              +S      V+ CL ++P  RP+A  
Sbjct: 254 ----------------------------------NYSKPLKEFVEACLNKEPSFRPTAKE 279

Query: 363 LLSHVFFKQMKEESQDSILSLLPPAYNK 390
           LL H F   ++   + S L+ L   Y +
Sbjct: 280 LLKHKFI--LRNAKKTSYLTELIDRYKR 305


>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
           [Homo sapiens]
          Length = 894

 Score =  104 bits (260), Expect = 1e-22
 Identities = 88/317 (27%), Positives = 136/317 (42%), Gaps = 60/317 (18%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   IG G      V+ AR+  TG L  IK+  LE    E    +Q+ +I+    +HP
Sbjct: 16  FELIQRIGSG--TYGDVYKARNVNTGELAAIKVIKLEP--GEDFAVVQQEIIMMKDCKHP 71

Query: 118 NITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQ 177
           NI  Y+  +     LW+   F   GS   +     P  +SE  I  +    ++GL YLH 
Sbjct: 72  NIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP--LSELQIAYVSRETLQGLYYLHS 129

Query: 178 NGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPEL 237
            G +HR IK ++IL++ +G V L+       +     + ++    P        W++PE+
Sbjct: 130 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY-------WMAPEV 182

Query: 238 LRQDLH-GYNVKSDIYSVGITACELASGQVPFQDMH--RTQMLLQKLKGPPYSPLDISIF 294
              +   GYN   D+++VGITA ELA  Q P  D+H  R   L+ K    P         
Sbjct: 183 AAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQP--------- 233

Query: 295 PQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDP 354
           P+ + +MK                                   +S +F   V++ L ++P
Sbjct: 234 PKLKDKMK-----------------------------------WSNSFHHFVKMALTKNP 258

Query: 355 EKRPSASSLLSHVFFKQ 371
           +KRP+A  LL H F  Q
Sbjct: 259 KKRPTAEKLLQHPFVTQ 275


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score =  104 bits (259), Expect = 2e-22
 Identities = 89/329 (27%), Positives = 135/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K   +  +L  +  H 
Sbjct: 25  FELVEVVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL--EINMLKKYSHHR 80

Query: 118 NITTYWTVFTVGS------WLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F   S       LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L +LH +  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ +SD++S GITA E+A G  P  DMH  + L    + PP   
Sbjct: 194 WMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPP--- 250

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  FFS ++ 
Sbjct: 251 ----------PRLK--------------------------------SKKWSKKFFSFIEG 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RPS   LL H F +    E Q
Sbjct: 269 CLVKNYMQRPSTEQLLKHPFIRDQPNERQ 297


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score =  104 bits (259), Expect = 2e-22
 Identities = 89/329 (27%), Positives = 135/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K   +  +L  +  H 
Sbjct: 25  FELVEVVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL--EINMLKKYSHHR 80

Query: 118 NITTYWTVFTVGS------WLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F   S       LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L +LH +  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ +SD++S GITA E+A G  P  DMH  + L    + PP   
Sbjct: 194 WMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPP--- 250

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  FFS ++ 
Sbjct: 251 ----------PRLK--------------------------------SKKWSKKFFSFIEG 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RPS   LL H F +    E Q
Sbjct: 269 CLVKNYMQRPSTEQLLKHPFIRDQPNERQ 297


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score =  104 bits (259), Expect = 2e-22
 Identities = 89/329 (27%), Positives = 135/329 (41%), Gaps = 65/329 (19%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K   +  +L  +  H 
Sbjct: 25  FELVEVVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL--EINMLKKYSHHR 80

Query: 118 NITTYWTVFTVGS------WLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F   S       LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L +LH +  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSP 288
           W++PE++  D +    Y+ +SD++S GITA E+A G  P  DMH  + L    + PP   
Sbjct: 194 WMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPP--- 250

Query: 289 LDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQL 348
                      R+K                                SK +S  FFS ++ 
Sbjct: 251 ----------PRLK--------------------------------SKKWSKKFFSFIEG 268

Query: 349 CLQQDPEKRPSASSLLSHVFFKQMKEESQ 377
           CL ++  +RPS   LL H F +    E Q
Sbjct: 269 CLVKNYMQRPSTEQLLKHPFIRDQPNERQ 297


>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
           1 isoform 1 [Homo sapiens]
          Length = 821

 Score =  101 bits (252), Expect = 1e-21
 Identities = 100/356 (28%), Positives = 149/356 (41%), Gaps = 68/356 (19%)

Query: 57  HYELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRH 116
           HY+L   +G G      V  AR   +G LV +K+  +E   ++ +  LQK +++    RH
Sbjct: 16  HYDLLQRLGGG--TYGEVFKARDKVSGDLVALKMVKMEP--DDDVSTLQKEILILKTCRH 71

Query: 117 PNITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLH 176
            NI  Y   +     LW+   F   GS   + +      +SE  I  +    ++GL YLH
Sbjct: 72  ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQV--TGSLSELQISYVCREVLQGLAYLH 129

Query: 177 QNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPE 236
               IHR IK ++ILI+  G V L+       +     R  +    P        W++PE
Sbjct: 130 SQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPY-------WMAPE 182

Query: 237 LLRQDLHG-YNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFP 295
           +    L G YN   DI+S+GITA ELA  Q P  D+H  ++L    K   Y P      P
Sbjct: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKS-GYQP------P 235

Query: 296 QSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPE 355
           + + + K                                   +S AF + +++ L + P+
Sbjct: 236 RLKEKGK-----------------------------------WSAAFHNFIKVTLTKSPK 260

Query: 356 KRPSASSLLSHVFFKQMKEESQDSILSLLPPAYNK---PSI--------SLPPVLP 400
           KRPSA+ +LSH    Q    ++  IL LL    N    PSI         LPP +P
Sbjct: 261 KRPSATKMLSHQLVSQ-PGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIP 315


>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
           isoform 2 [Homo sapiens]
          Length = 833

 Score =  101 bits (252), Expect = 1e-21
 Identities = 100/356 (28%), Positives = 149/356 (41%), Gaps = 68/356 (19%)

Query: 57  HYELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRH 116
           HY+L   +G G      V  AR   +G LV +K+  +E   ++ +  LQK +++    RH
Sbjct: 16  HYDLLQRLGGG--TYGEVFKARDKVSGDLVALKMVKMEP--DDDVSTLQKEILILKTCRH 71

Query: 117 PNITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLH 176
            NI  Y   +     LW+   F   GS   + +      +SE  I  +    ++GL YLH
Sbjct: 72  ANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQV--TGSLSELQISYVCREVLQGLAYLH 129

Query: 177 QNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPE 236
               IHR IK ++ILI+  G V L+       +     R  +    P        W++PE
Sbjct: 130 SQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPY-------WMAPE 182

Query: 237 LLRQDLHG-YNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFP 295
           +    L G YN   DI+S+GITA ELA  Q P  D+H  ++L    K   Y P      P
Sbjct: 183 VAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKS-GYQP------P 235

Query: 296 QSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPE 355
           + + + K                                   +S AF + +++ L + P+
Sbjct: 236 RLKEKGK-----------------------------------WSAAFHNFIKVTLTKSPK 260

Query: 356 KRPSASSLLSHVFFKQMKEESQDSILSLLPPAYNK---PSI--------SLPPVLP 400
           KRPSA+ +LSH    Q    ++  IL LL    N    PSI         LPP +P
Sbjct: 261 KRPSATKMLSHQLVSQ-PGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIP 315


>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  101 bits (252), Expect = 1e-21
 Identities = 87/333 (26%), Positives = 141/333 (42%), Gaps = 60/333 (18%)

Query: 42  PSTRASEVLCSTNVSHYELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERL 101
           P   A+++L       YEL   +G G      V+ AR+  TG L  +KI  LE  ++  L
Sbjct: 4   PLRPAADILRRNPQQDYELVQRVGSG--TYGDVYKARNVHTGELAAVKIIKLEPGDDFSL 61

Query: 102 KALQKAVILSHFFRHPNITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLI 161
             +Q+ + +    +H NI  Y+  +     LW+   +   GS   +     P  +SE  I
Sbjct: 62  --IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGP--LSELQI 117

Query: 162 RNILFGAVRGLNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYD 221
             +    ++GL YLH  G +HR IK ++IL++  G V L+       +     + ++   
Sbjct: 118 AYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIG 177

Query: 222 FPQFSTSVQPWLSPELLRQDLH-GYNVKSDIYSVGITACELASGQVPFQDMH--RTQMLL 278
            P        W++PE+   + + GYN   DI++VGITA EL   Q P  D+H  R   L+
Sbjct: 178 TPY-------WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLM 230

Query: 279 QKLKGPPYSPLDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTF 338
            K    P         P+ + + K                                   +
Sbjct: 231 SKSNFQP---------PKLKDKTK-----------------------------------W 246

Query: 339 SPAFFSLVQLCLQQDPEKRPSASSLLSHVFFKQ 371
           S  F + V++ L ++P+KRP+A  LL+H F  Q
Sbjct: 247 SSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279


>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  101 bits (252), Expect = 1e-21
 Identities = 87/333 (26%), Positives = 141/333 (42%), Gaps = 60/333 (18%)

Query: 42  PSTRASEVLCSTNVSHYELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERL 101
           P   A+++L       YEL   +G G      V+ AR+  TG L  +KI  LE  ++  L
Sbjct: 4   PLRPAADILRRNPQQDYELVQRVGSG--TYGDVYKARNVHTGELAAVKIIKLEPGDDFSL 61

Query: 102 KALQKAVILSHFFRHPNITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLI 161
             +Q+ + +    +H NI  Y+  +     LW+   +   GS   +     P  +SE  I
Sbjct: 62  --IQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGP--LSELQI 117

Query: 162 RNILFGAVRGLNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYD 221
             +    ++GL YLH  G +HR IK ++IL++  G V L+       +     + ++   
Sbjct: 118 AYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIG 177

Query: 222 FPQFSTSVQPWLSPELLRQDLH-GYNVKSDIYSVGITACELASGQVPFQDMH--RTQMLL 278
            P        W++PE+   + + GYN   DI++VGITA EL   Q P  D+H  R   L+
Sbjct: 178 TPY-------WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLM 230

Query: 279 QKLKGPPYSPLDISIFPQSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTF 338
            K    P         P+ + + K                                   +
Sbjct: 231 SKSNFQP---------PKLKDKTK-----------------------------------W 246

Query: 339 SPAFFSLVQLCLQQDPEKRPSASSLLSHVFFKQ 371
           S  F + V++ L ++P+KRP+A  LL+H F  Q
Sbjct: 247 SSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQ 279


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score =  100 bits (249), Expect = 2e-21
 Identities = 72/237 (30%), Positives = 110/237 (46%), Gaps = 20/237 (8%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVEVVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFTVGS------WLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F   S       LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L +LH +  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPP 285
           W++PE++  D +    Y+ +SDI+S+GITA E+A G  P  DMH  + L    + PP
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score =  100 bits (249), Expect = 2e-21
 Identities = 72/237 (30%), Positives = 110/237 (46%), Gaps = 20/237 (8%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVEVVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFTVGS------WLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F   S       LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L +LH +  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPP 285
           W++PE++  D +    Y+ +SDI+S+GITA E+A G  P  DMH  + L    + PP
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score =  100 bits (249), Expect = 2e-21
 Identities = 72/237 (30%), Positives = 110/237 (46%), Gaps = 20/237 (8%)

Query: 58  YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
           +EL   +G G      V+  RH  TG L  IK+ ++    EE +K  Q+  +L  +  H 
Sbjct: 25  FELVEVVGNG--TYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIK--QEINMLKKYSHHR 80

Query: 118 NITTYWTVFTVGS------WLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRG 171
           NI TY+  F   S       LW++  F   GS + L++      + E  I  I    +RG
Sbjct: 81  NIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRG 140

Query: 172 LNYLHQNGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQP 231
           L +LH +  IHR IK  ++L++ +  V L        L +   R       P        
Sbjct: 141 LAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY------- 193

Query: 232 WLSPELLRQDLH---GYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPP 285
           W++PE++  D +    Y+ +SDI+S+GITA E+A G  P  DMH  + L    + PP
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,829,598
Number of Sequences: 37866
Number of extensions: 741827
Number of successful extensions: 3617
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 371
Number of HSP's successfully gapped in prelim test: 321
Number of HSP's that attempted gapping in prelim test: 2356
Number of HSP's gapped (non-prelim): 1043
length of query: 418
length of database: 18,247,518
effective HSP length: 105
effective length of query: 313
effective length of database: 14,271,588
effective search space: 4467007044
effective search space used: 4467007044
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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