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Search of human proteins with 4504897
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504897 karyopherin alpha 2 [Homo sapiens]
(529 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504897 karyopherin alpha 2 [Homo sapiens] 1043 0.0
gi|224589129 karyopherin 7 [Homo sapiens] 544 e-155
gi|4504901 karyopherin alpha 4 [Homo sapiens] 514 e-145
gi|34485722 karyopherin alpha 3 [Homo sapiens] 499 e-141
gi|39812229 karyopherin alpha 5 [Homo sapiens] 458 e-129
gi|6912478 karyopherin alpha 6 [Homo sapiens] 452 e-127
gi|222144293 karyopherin alpha 1 [Homo sapiens] 439 e-123
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 69 8e-12
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 69 8e-12
gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens] 56 7e-08
gi|31657114 armadillo repeat containing 4 [Homo sapiens] 56 9e-08
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 55 2e-07
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD... 54 3e-07
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD... 54 3e-07
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ... 54 3e-07
gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5 [... 54 5e-07
gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4 [... 54 5e-07
gi|4504811 junction plakoglobin [Homo sapiens] 51 2e-06
gi|12056468 junction plakoglobin [Homo sapiens] 51 2e-06
gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens] 50 4e-06
gi|189409124 armadillo repeat containing 3 [Homo sapiens] 47 3e-05
gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens] 47 4e-05
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [... 44 3e-04
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [... 44 4e-04
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [... 44 4e-04
gi|53829376 plakophilin 4 isoform b [Homo sapiens] 42 0.001
gi|53829374 plakophilin 4 isoform a [Homo sapiens] 42 0.001
gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens] 38 0.020
gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens] 38 0.020
gi|4826952 proteasome 26S non-ATPase subunit 5 [Homo sapiens] 37 0.058
>gi|4504897 karyopherin alpha 2 [Homo sapiens]
Length = 529
Score = 1043 bits (2696), Expect = 0.0
Identities = 529/529 (100%), Positives = 529/529 (100%)
Query: 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA 60
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
Sbjct: 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA 60
Query: 61 TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL 120
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
Sbjct: 61 TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL 120
Query: 121 IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE 180
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
Sbjct: 121 IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE 180
Query: 181 QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK 240
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
Sbjct: 181 QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK 240
Query: 241 NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK 300
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
Sbjct: 241 NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK 300
Query: 301 LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS 360
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
Sbjct: 301 LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS 360
Query: 361 NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG 420
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
Sbjct: 361 NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG 420
Query: 421 IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE 480
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
Sbjct: 421 IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE 480
Query: 481 NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 529
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
Sbjct: 481 NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF 529
>gi|224589129 karyopherin 7 [Homo sapiens]
Length = 516
Score = 544 bits (1401), Expect = e-155
Identities = 280/510 (54%), Positives = 371/510 (72%), Gaps = 7/510 (1%)
Query: 8 NTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQEN 67
+ P R +FK +GKD + R++R+ V++ELRKAKKD+Q LKRRN++SF D S E
Sbjct: 5 DAPEERRRKFKYRGKDVSLRRQQRMAVSLELRKAKKDEQTLKRRNITSFCPDTPS---EK 61
Query: 68 RNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSF 127
V+ ++ +I+KG+NSS+ QATQ ARK+LS+EK PP+ +I AGLIP+ V F
Sbjct: 62 TAKGVAVSLTLGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPRMVEF 121
Query: 128 LGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALG 187
L + +QFE+AWALTNIASGTSEQT+AVV+GGAI I LL+S + + EQAVWALG
Sbjct: 122 LKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALG 181
Query: 188 NIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPID 247
NIAGDG FRD VI A+ LLAL++ +L +LRN+TWTLSNLCRNKNP P
Sbjct: 182 NIAGDGPEFRDNVITSNAIPHLLALIS----PTLPITFLRNITWTLSNLCRNKNPYPCDT 237
Query: 248 AVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASEL 307
AV+QILP L+ LL H D EVL+D CWA+SYLTDG N+RIG VV TGV+P+LV L+ +SEL
Sbjct: 238 AVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSEL 297
Query: 308 PIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQ 367
++TP+LR +GNIVTGTDEQTQ+ IDAG L V P LL + K +IQKEA W +SN+ AG
Sbjct: 298 NVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPC 357
Query: 368 DQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMN 427
IQQ++ + ++P LV++L +FK QKEAVW V N+ +G T++Q++ LVH G++EPL+N
Sbjct: 358 HHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVN 417
Query: 428 LLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKA 487
LLTA D KI+L+ILD IS I QAAEK E E L ++IEE GG+D+IEALQ HEN + ++
Sbjct: 418 LLTAPDVKIVLIILDVISCILQAAEKRSEKENLCLLIEELGGIDRIEALQLHENRQIGQS 477
Query: 488 SLSLIEKYFSVEEEEDQNVVPETTSEGYTF 517
+L++IEK+F EE+E Q ++ + + Y F
Sbjct: 478 ALNIIEKHFGEEEDESQTLLSQVIDQDYEF 507
>gi|4504901 karyopherin alpha 4 [Homo sapiens]
Length = 521
Score = 514 bits (1323), Expect = e-145
Identities = 265/520 (50%), Positives = 356/520 (68%), Gaps = 11/520 (2%)
Query: 5 ENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPL 64
+N RL FKNKG+D MRR+R EV VELRK K+D+ +LKRRNV P +
Sbjct: 3 DNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNV---PHEDICED 59
Query: 65 QENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKF 124
+ + N S++ IV+ +S N QL A QAARKLLS ++ PPID++I++G++P
Sbjct: 60 SDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPIL 119
Query: 125 VSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVW 184
V L R D +QFE+AWALTNIASGTSEQT+AVV A+P F+ LL SPH ++ EQAVW
Sbjct: 120 VHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVW 179
Query: 185 ALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAP 244
ALGNI GDG RD VI G V PLL+ ++ S+ +LRN+TW + NLCR+K+P P
Sbjct: 180 ALGNIIGDGPQCRDYVISLGVVKPLLSFIS----PSIPITFLRNVTWVMVNLCRHKDPPP 235
Query: 245 PIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGA 304
P++ +++ILP L L+HH D +L DT WA+SYLTD NE+I MV+ +G+VP LV LL
Sbjct: 236 PMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSH 295
Query: 305 SELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 364
E+ + T ALRA+GNIVTGTDEQTQVV++ AL+ FP+LLT+PK I KEA W +SNITA
Sbjct: 296 QEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITA 355
Query: 365 GRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEP 424
G Q Q+Q V++ LVP ++ +L K DF TQKEA WA++N T G +Q+ YL+ +I P
Sbjct: 356 GNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPP 415
Query: 425 LMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESV 484
NLLT KD +++ V+LD +SNI + AE E E + +IEECGGL+KIE LQNHENE +
Sbjct: 416 FCNLLTVKDAQVVQVVLDGLSNILKMAE--DEAETIGNLIEECGGLEKIEQLQNHENEDI 473
Query: 485 YKASLSLIEKYFSVEE-EEDQNVVPETTSEGYTFQVQDGA 523
YK + +I+++FS ++ +ED ++VPE +G TF A
Sbjct: 474 YKLAYEIIDQFFSSDDIDEDPSLVPEAI-QGGTFGFNSSA 512
>gi|34485722 karyopherin alpha 3 [Homo sapiens]
Length = 521
Score = 499 bits (1285), Expect = e-141
Identities = 259/515 (50%), Positives = 350/515 (67%), Gaps = 11/515 (2%)
Query: 5 ENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPL 64
EN + R+ FKNKG+D MRR R EV VELRK K+D+ +LK+RNV S +
Sbjct: 3 ENPSLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDV 62
Query: 65 QENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKF 124
+ Q N +++ I++ S N QL A QAARKLLS ++ PPID++I++G++P
Sbjct: 63 DADFKAQ---NVTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPIL 119
Query: 125 VSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVW 184
V L R D +QFE+AWALTNIASGTS QT+AVV A+P F+ LL SPH ++ EQAVW
Sbjct: 120 VKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVW 179
Query: 185 ALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAP 244
ALGNI GDG RD VI G V PLL+ ++ S+ +LRN+TW + NLCRNK+P P
Sbjct: 180 ALGNIIGDGPQCRDYVISLGVVKPLLSFIS----PSIPITFLRNVTWVIVNLCRNKDPPP 235
Query: 245 PIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGA 304
P++ V++ILP L L++H D +L DT WA+SYLTDG NE+I MV+ +GVVP LV LL
Sbjct: 236 PMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSH 295
Query: 305 SELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 364
E+ + T ALRA+GNIVTGTDEQTQVV++ L+ FP+LL++PK I KEA W +SNITA
Sbjct: 296 QEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITA 355
Query: 365 GRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEP 424
G Q Q+Q V++ GL+P ++ L+K DF TQKEA WA++N T G +Q+ YLV +I P
Sbjct: 356 GNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPP 415
Query: 425 LMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESV 484
NLL+ KD++++ V+LD + NI A E ++ +IEECGGL+KIE LQ HENE +
Sbjct: 416 FCNLLSVKDSQVVQVVLDGLKNILIMAG--DEASTIAEIIEECGGLEKIEVLQQHENEDI 473
Query: 485 YKASLSLIEKYFSVEE-EEDQNVVPETTSEG-YTF 517
YK + +I++YFS ++ +ED ++PE T G Y F
Sbjct: 474 YKLAFEIIDQYFSGDDIDEDPCLIPEATQGGTYNF 508
>gi|39812229 karyopherin alpha 5 [Homo sapiens]
Length = 539
Score = 458 bits (1179), Expect = e-129
Identities = 254/525 (48%), Positives = 345/525 (65%), Gaps = 22/525 (4%)
Query: 13 RLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDAT---SPLQENRN 69
R+ +KNK + EMRRRR E ++LRK K+++Q+ KRRNV +D + SP+Q+ +
Sbjct: 13 RMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVYLPRNDESMLESPIQDP-D 71
Query: 70 NQGTVNWSVD-----DIVKGINSSNVENQLQATQAARKLLSREKQPPIDNII-RAGLIPK 123
TV + D+V+ I S+N + QL ATQ RKLLS+E PPID +I + G++ +
Sbjct: 72 ISSTVPIPEEEVVTTDMVQMIFSNNADQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQR 131
Query: 124 FVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAV 183
FV FL R + +QFE+AWALTNIASGT TK V++ GA+P FI LL S H + EQAV
Sbjct: 132 FVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIKLLNSEHEDVQEQAV 191
Query: 184 WALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPA 243
WALGNIAGD + RD V+ + PLL LL +S RN W LSNLCR KNP
Sbjct: 192 WALGNIAGDNAECRDFVLNCEILPPLLELLT----NSNRLTTTRNAVWALSNLCRGKNPP 247
Query: 244 PPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLG 303
P V L L RLL DP+VLAD CWA+SYL+DGPN++I V+ +GV +LV+LL
Sbjct: 248 PNFSKVSPCLNVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQAVIDSGVCRRLVELLM 307
Query: 304 ASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT 363
++ +V+PALRA+GNIVTG D QTQV+++ AL LL++PK +I+KEA WT+SNIT
Sbjct: 308 HNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTVSNIT 367
Query: 364 AGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIE 423
AG + QIQ V++ + P L+ +L KA+F+T+KEA WA+TN TSGGT EQI YLV G I+
Sbjct: 368 AGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVALGCIK 427
Query: 424 PLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSI-----MIEECGGLDKIEALQN 478
PL +LLT D+KI+ V L+ + NI + E+ + + I +IEE GLDKIE LQ+
Sbjct: 428 PLCDLLTVMDSKIVQVALNGLENILRLGEQESKQNGIGINPYCALIEEAYGLDKIEFLQS 487
Query: 479 HENESVYKASLSLIEKYFSVEEEEDQNVVPET--TSEGYTFQVQD 521
HEN+ +Y+ + LIE YF V EE+D ++VP+ + + FQ Q+
Sbjct: 488 HENQEIYQKAFDLIEHYFGV-EEDDPSIVPQVDENQQQFIFQQQE 531
>gi|6912478 karyopherin alpha 6 [Homo sapiens]
Length = 536
Score = 452 bits (1163), Expect = e-127
Identities = 252/536 (47%), Positives = 341/536 (63%), Gaps = 18/536 (3%)
Query: 1 MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA 60
M T + R+ +KN + EMRRRR E ++LRK K++ Q+ KRRNV ++A
Sbjct: 1 METMASPGKDNYRMKSYKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELINEEA 60
Query: 61 T--SPLQENRNNQGTVNWSV--DDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNII 116
L + T SV ++V+ + S + + QL TQ RKLLS+E PPID +I
Sbjct: 61 AMFDSLLMDSYVSSTTGESVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVI 120
Query: 117 RAG-LIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPH 175
++ +FV FL R + +QFE+AWALTNIASGTS+QTK V++ GA+P FI LL S
Sbjct: 121 NTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDF 180
Query: 176 AHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSN 235
+ EQAVWALGNIAGD SV RD V+ ++PLL LL S RN W LSN
Sbjct: 181 EDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLT----KSTRLTMTRNAVWALSN 236
Query: 236 LCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVV 295
LCR KNP P V LP L RLL D ++LAD CWA+SYL+DGPNE+I V+ +GV
Sbjct: 237 LCRGKNPPPEFAKVSPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVC 296
Query: 296 PQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEA 355
+LV+LL ++ + +PALRA+GNIVTG D QTQV+++ AL LL++PK +I+KEA
Sbjct: 297 RRLVELLMHNDYKVASPALRAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEA 356
Query: 356 TWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVY 415
WT+SNITAG + QIQ V++ + P L+ +L KA+F+T+KEA WA+TN TSGGT EQI Y
Sbjct: 357 CWTISNITAGNRAQIQAVIDANIFPVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRY 416
Query: 416 LVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSI-----MIEECGGL 470
LV G I+PL +LLT D+KI+ V L+ + NI + E+ G+ + +IEE GL
Sbjct: 417 LVSLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEGKRSGSGVNPYCGLIEEAYGL 476
Query: 471 DKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPET--TSEGYTFQVQDGAP 524
DKIE LQ+HEN+ +Y+ + LIE YF V E++D ++ P+ T + + FQ Q AP
Sbjct: 477 DKIEFLQSHENQEIYQKAFDLIEHYFGV-EDDDSSLAPQVDETQQQFIFQ-QPEAP 530
>gi|222144293 karyopherin alpha 1 [Homo sapiens]
Length = 538
Score = 439 bits (1130), Expect = e-123
Identities = 241/523 (46%), Positives = 333/523 (63%), Gaps = 22/523 (4%)
Query: 13 RLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENR---- 68
RL +KNK + EMRRRR E ++LRK K+++Q+ KRRNV++ ++ + +
Sbjct: 10 RLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHE 69
Query: 69 ---NNQGTVNWSV--DDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRA-GLIP 122
+N V D+++ I S + E QL ATQ RKLLS+E PPID +I G++
Sbjct: 70 AQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVA 129
Query: 123 KFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQA 182
+FV FL R + +QFESAW LTNIASG S QT+ V+ GA+P FI LL+S + EQA
Sbjct: 130 RFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQA 189
Query: 183 VWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNP 242
VWALGNIAGD ++ RD V+ + PLL L + + ++ RN W LSNLCR K+P
Sbjct: 190 VWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMT----RNAVWALSNLCRGKSP 245
Query: 243 APPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLL 302
P V L L LL D +VLAD CWA+SYL+DGPN++I V+ GV +LV+LL
Sbjct: 246 PPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELL 305
Query: 303 GASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNI 362
++ +V+PALRA+GNIVTG D QTQV+++ AL LL++PK +I+KEA WT+SNI
Sbjct: 306 MHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNI 365
Query: 363 TAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGII 422
TAG + QIQ V++ + P L+S+L A+F+T+KEA WA+TN TSGG+ EQI YLV G I
Sbjct: 366 TAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCI 425
Query: 423 EPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSI-----MIEECGGLDKIEALQ 477
+PL +LLT D+KI+ V L+ + NI + E+ + I +IEE GLDKIE LQ
Sbjct: 426 KPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQ 485
Query: 478 NHENESVYKASLSLIEKYFSVEEEEDQNVVPET--TSEGYTFQ 518
+HEN+ +Y+ + LIE YF E+ED ++ P+ + Y FQ
Sbjct: 486 SHENQEIYQKAFDLIEHYFGT-EDEDSSIAPQVDLNQQQYIFQ 527
>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
Length = 509
Score = 69.3 bits (168), Expect = 8e-12
Identities = 56/247 (22%), Positives = 100/247 (40%), Gaps = 6/247 (2%)
Query: 140 SAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDL 199
+AWAL IA +E ++AVVD GA+P + + P + A AL +IA
Sbjct: 145 AAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
Query: 200 VIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRL 259
V+ GAV L ++ PD + LS + ++ + +I P ++
Sbjct: 205 VVDAGAVAHLAQMILNPDAK-----LKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTC 259
Query: 260 LHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGN 319
L D V + I + E +VV G V ++ +G+ + P + +G
Sbjct: 260 LKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGY 319
Query: 320 IVTGTDEQTQ-VVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGL 378
+ ++ V+I G + L P+ +I+ A W + I + + V
Sbjct: 320 VAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNT 379
Query: 379 VPFLVSV 385
+P L+S+
Sbjct: 380 LPVLLSL 386
Score = 68.6 bits (166), Expect = 1e-11
Identities = 58/245 (23%), Positives = 100/245 (40%), Gaps = 5/245 (2%)
Query: 153 EQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLAL 212
+ + + + G + +LL I + A ALG +A + V+K + L+
Sbjct: 32 QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
Query: 213 LAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTC 272
LA + Y + + L + ++ L TLV L DP V
Sbjct: 92 LAEQNRF-----YKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAA 146
Query: 273 WAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVI 332
WA+ Y+ E VV G VP LV + E+ + A A+ +I + E Q V+
Sbjct: 147 WALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVV 206
Query: 333 DAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFK 392
DAGA+A ++ NP ++ + +S ++ D + VV + P +++ L D
Sbjct: 207 DAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEY 266
Query: 393 TQKEA 397
+K A
Sbjct: 267 VKKNA 271
Score = 55.8 bits (133), Expect = 9e-08
Identities = 58/288 (20%), Positives = 121/288 (42%), Gaps = 7/288 (2%)
Query: 115 IIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP 174
+++ ++P+ V L + + +A+ L + + + +A+VD GA+ + L
Sbjct: 79 VVKCDILPQLVYSLAEQNRF-YKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDF 137
Query: 175 HAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLS 234
+ E A WAL IA + V+ GAV L+ + P+++ R LS
Sbjct: 138 DPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIA-----LKRIAASALS 192
Query: 235 NLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGV 294
++ ++ + L +++ + D ++ A+S ++ + MVV+ +
Sbjct: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
Query: 295 VPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKE 354
P ++ L + + A I I T E +Q+V++AG +A + + K N +
Sbjct: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLP 312
Query: 355 ATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLS-KADFKTQKEAVWAV 401
+ + A ++ V+ VP L LS + + + A WA+
Sbjct: 313 GIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/259 (23%), Positives = 107/259 (41%), Gaps = 13/259 (5%)
Query: 252 ILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVT 311
++ L LL P + A+ L + ++ VVK ++PQLV L
Sbjct: 42 VMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKK 101
Query: 312 PA---LRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQD 368
A LRA+G + + Q ++D GAL L + +++ A W + I +
Sbjct: 102 AAAFVLRAVGK---HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAE 158
Query: 369 QIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNL 428
Q VV+ G VP LV + + + ++ A A+++ + E +V G + L +
Sbjct: 159 LSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK-HSPELAQTVVDAGAVAHLAQM 217
Query: 429 LTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKAS 488
+ D K+ IL A+S + + + L E M+ E + ++E V K +
Sbjct: 218 ILNPDAKLKHQILSALSQVSKHSVDLAE------MVVEAEIFPVVLTCLKDKDEYVKKNA 271
Query: 489 LSLIEKYFSVEEEEDQNVV 507
+LI + E Q VV
Sbjct: 272 STLIREIAKHTPELSQLVV 290
Score = 43.1 bits (100), Expect = 6e-04
Identities = 44/182 (24%), Positives = 80/182 (43%), Gaps = 7/182 (3%)
Query: 289 VVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPK 348
+V G + LV L + + A A+ I E +Q V+DAGA+ + + P+
Sbjct: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180
Query: 349 TNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGG 408
+++ A +S+I + Q VV+ G V L ++ D K K + + + S
Sbjct: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKL-KHQILSALSQVSKH 239
Query: 409 TVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECG 468
+V+ +V I ++ L KD V +A + I + A+ T +LS ++ G
Sbjct: 240 SVDLAEMVVEAEIFPVVLTCLKDKDE---YVKKNASTLIREIAK---HTPELSQLVVNAG 293
Query: 469 GL 470
G+
Sbjct: 294 GV 295
Score = 35.4 bits (80), Expect = 0.13
Identities = 36/174 (20%), Positives = 68/174 (39%), Gaps = 1/174 (0%)
Query: 284 ERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSL 343
+ I + GV+ L LL I A A+G + D+ + V+ L
Sbjct: 32 QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
Query: 344 LTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTN 403
L +K A + + + Q +V+ G + LV L D ++ A WA+
Sbjct: 92 LAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWAL-R 150
Query: 404 YTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGET 457
Y + E +V G + L+ + + + + A+S+I + + +L +T
Sbjct: 151 YIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
Length = 458
Score = 69.3 bits (168), Expect = 8e-12
Identities = 56/247 (22%), Positives = 100/247 (40%), Gaps = 6/247 (2%)
Query: 140 SAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDL 199
+AWAL IA +E ++AVVD GA+P + + P + A AL +IA
Sbjct: 145 AAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
Query: 200 VIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRL 259
V+ GAV L ++ PD + LS + ++ + +I P ++
Sbjct: 205 VVDAGAVAHLAQMILNPDAK-----LKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTC 259
Query: 260 LHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGN 319
L D V + I + E +VV G V ++ +G+ + P + +G
Sbjct: 260 LKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGY 319
Query: 320 IVTGTDEQTQ-VVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGL 378
+ ++ V+I G + L P+ +I+ A W + I + + V
Sbjct: 320 VAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNT 379
Query: 379 VPFLVSV 385
+P L+S+
Sbjct: 380 LPVLLSL 386
Score = 68.6 bits (166), Expect = 1e-11
Identities = 58/245 (23%), Positives = 100/245 (40%), Gaps = 5/245 (2%)
Query: 153 EQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLAL 212
+ + + + G + +LL I + A ALG +A + V+K + L+
Sbjct: 32 QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
Query: 213 LAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTC 272
LA + Y + + L + ++ L TLV L DP V
Sbjct: 92 LAEQNRF-----YKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAA 146
Query: 273 WAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVI 332
WA+ Y+ E VV G VP LV + E+ + A A+ +I + E Q V+
Sbjct: 147 WALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVV 206
Query: 333 DAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFK 392
DAGA+A ++ NP ++ + +S ++ D + VV + P +++ L D
Sbjct: 207 DAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEY 266
Query: 393 TQKEA 397
+K A
Sbjct: 267 VKKNA 271
Score = 55.8 bits (133), Expect = 9e-08
Identities = 58/288 (20%), Positives = 121/288 (42%), Gaps = 7/288 (2%)
Query: 115 IIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP 174
+++ ++P+ V L + + +A+ L + + + +A+VD GA+ + L
Sbjct: 79 VVKCDILPQLVYSLAEQNRF-YKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDF 137
Query: 175 HAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLS 234
+ E A WAL IA + V+ GAV L+ + P+++ R LS
Sbjct: 138 DPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIA-----LKRIAASALS 192
Query: 235 NLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGV 294
++ ++ + L +++ + D ++ A+S ++ + MVV+ +
Sbjct: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
Query: 295 VPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKE 354
P ++ L + + A I I T E +Q+V++AG +A + + K N +
Sbjct: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLP 312
Query: 355 ATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLS-KADFKTQKEAVWAV 401
+ + A ++ V+ VP L LS + + + A WA+
Sbjct: 313 GIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWAL 360
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/259 (23%), Positives = 107/259 (41%), Gaps = 13/259 (5%)
Query: 252 ILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVT 311
++ L LL P + A+ L + ++ VVK ++PQLV L
Sbjct: 42 VMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKK 101
Query: 312 PA---LRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQD 368
A LRA+G + + Q ++D GAL L + +++ A W + I +
Sbjct: 102 AAAFVLRAVGK---HSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAE 158
Query: 369 QIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNL 428
Q VV+ G VP LV + + + ++ A A+++ + E +V G + L +
Sbjct: 159 LSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAK-HSPELAQTVVDAGAVAHLAQM 217
Query: 429 LTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKAS 488
+ D K+ IL A+S + + + L E M+ E + ++E V K +
Sbjct: 218 ILNPDAKLKHQILSALSQVSKHSVDLAE------MVVEAEIFPVVLTCLKDKDEYVKKNA 271
Query: 489 LSLIEKYFSVEEEEDQNVV 507
+LI + E Q VV
Sbjct: 272 STLIREIAKHTPELSQLVV 290
Score = 43.1 bits (100), Expect = 6e-04
Identities = 44/182 (24%), Positives = 80/182 (43%), Gaps = 7/182 (3%)
Query: 289 VVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPK 348
+V G + LV L + + A A+ I E +Q V+DAGA+ + + P+
Sbjct: 121 IVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPE 180
Query: 349 TNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGG 408
+++ A +S+I + Q VV+ G V L ++ D K K + + + S
Sbjct: 181 IALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKL-KHQILSALSQVSKH 239
Query: 409 TVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECG 468
+V+ +V I ++ L KD V +A + I + A+ T +LS ++ G
Sbjct: 240 SVDLAEMVVEAEIFPVVLTCLKDKDE---YVKKNASTLIREIAK---HTPELSQLVVNAG 293
Query: 469 GL 470
G+
Sbjct: 294 GV 295
Score = 35.4 bits (80), Expect = 0.13
Identities = 36/174 (20%), Positives = 68/174 (39%), Gaps = 1/174 (0%)
Query: 284 ERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSL 343
+ I + GV+ L LL I A A+G + D+ + V+ L
Sbjct: 32 QNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYS 91
Query: 344 LTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTN 403
L +K A + + + Q +V+ G + LV L D ++ A WA+
Sbjct: 92 LAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWAL-R 150
Query: 404 YTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGET 457
Y + E +V G + L+ + + + + A+S+I + + +L +T
Sbjct: 151 YIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQT 204
>gi|94536840 transmembrane and coiled-coil domains 6 [Homo sapiens]
Length = 493
Score = 56.2 bits (134), Expect = 7e-08
Identities = 102/491 (20%), Positives = 198/491 (40%), Gaps = 64/491 (13%)
Query: 26 EMRRRRIEVNVELRKAKKDDQMLKRRNV-SSFPDDATSPLQENRNNQGTVNWSVDDIVKG 84
E+RRRR E LRKA+++ Q++ +R + + P++A + V + +G
Sbjct: 18 ELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQFLRQAQRG 77
Query: 85 INSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWAL 144
E L + + R L E Q I G + V L ++ + +Q E+A L
Sbjct: 78 TEEKEREGALVSLR--RGLQHPETQQTF--IRLEGSMRTLVGLL-TSNQALLQLEAARCL 132
Query: 145 TNIASGTSEQTKAVVDGGAIPAFISLLASPHAHIS---EQAVWALGNIAGDGSVFRDLVI 201
+ S ++ V +PA LL +H S E ++ LGN+ + R ++
Sbjct: 133 HEL----SHSEQSTVAEACLPATSYLLTYLSSHSSDFIELCLYTLGNLIVESEAVRRQLL 188
Query: 202 KYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLV--RL 259
G V L A + P ++ L L + LS L + + +A E+I+P+++ L
Sbjct: 189 PQGIVPALAACIQSPHVA-----VLEALGYALSQLLQAE------EAPEKIIPSILASTL 237
Query: 260 LHHD----------DPEVLADTCWAISYLTDGPNER---IGMVVKTGVVPQLVKLLGASE 306
H +P V + W + Y+ IG + + L+ L GA +
Sbjct: 238 PQHMLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSNPLLIGHGALSTLGLLLLDLAGAVQ 297
Query: 307 LP-------IVTPALRAIGNIVT-------GTDEQTQVVIDAGALAVFPSLLTNPKTNIQ 352
+ P LR + N++T G Q + AL + + ++
Sbjct: 298 KTEDAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAALFILLQFFFQKQPSLL 357
Query: 353 KEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQ 412
E W ++N+TA +++ L+ L+ +L ++ + + N G
Sbjct: 358 PEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNV-VSVMVLTVLCNVAEKGPA-Y 415
Query: 413 IVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDK 472
L ++ L++ L DT+++ L+ + +F L + E + + +++ G
Sbjct: 416 CQRLWPGPLLPALLHTLAFSDTEVVGQSLELLHLLF-----LYQPEAVQVFLQQSG---- 466
Query: 473 IEALQNHENES 483
++AL+ H+ E+
Sbjct: 467 LQALERHQEEA 477
>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
Length = 1044
Score = 55.8 bits (133), Expect = 9e-08
Identities = 66/284 (23%), Positives = 113/284 (39%), Gaps = 13/284 (4%)
Query: 164 IPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLAC 223
I + L S + + E A+ A D RDLV +G + PL +LL D
Sbjct: 675 IENLVKNLNSENEQLQEHCAMAIYQCAEDKET-RDLVRLHGGLKPLASLLNNTDNKERLA 733
Query: 224 GYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPN 283
+ W S N A+E TLV LL EVL + A+
Sbjct: 734 A-VTGAIWKCSISKENVTKFREYKAIE----TLVGLLTDQPEEVLVNVVGALGECCQERE 788
Query: 284 ERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDA-GALAVFPS 342
R+ +V K G + LV LL ++ +A+G + ++ ++ID + + S
Sbjct: 789 NRV-IVRKCGGIQPLVNLLVGINQALLVNVTKAVG--ACAVEPESMMIIDRLDGVRLLWS 845
Query: 343 LLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNH-GLVPFLVSVLSKADFKTQKEAVWAV 401
LL NP +++ A W + +D + V + G + +V++L + + A+
Sbjct: 846 LLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAI 905
Query: 402 TNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAIS 445
TN E + + G++ L L + K+ + +AIS
Sbjct: 906 TNIAK--DQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAIS 947
Score = 45.8 bits (107), Expect = 1e-04
Identities = 69/305 (22%), Positives = 121/305 (39%), Gaps = 32/305 (10%)
Query: 158 VVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALL---- 213
+VD G +P +++L SPH + A + N+A R +V ++G + L+ALL
Sbjct: 531 IVDLGGLPIMVNILDSPHKSLKCLAAETIANVAKFKRA-RRVVRQHGGITKLVALLDCAH 589
Query: 214 --AVPDMSSL---------ACGYLRNLTWTLSNLCRNKNPAPPIDAVEQI--LPTLVRLL 260
P SSL CG L W+ S NK +A+ + +P L RLL
Sbjct: 590 DSTKPAQSSLYEARDVEVARCGAL--ALWSCSKSHTNK------EAIRKAGGIPLLARLL 641
Query: 261 HHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNI 320
+L + N R + + ++ LVK L + + AI
Sbjct: 642 KTSHENMLIPVVGTLQECASEENYRAAIKAER-IIENLVKNLNSENEQLQEHCAMAI--Y 698
Query: 321 VTGTDEQTQVVIDA-GALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLV 379
D++T+ ++ G L SLL N + A + ++ + + + +
Sbjct: 699 QCAEDKETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAI 758
Query: 380 PFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILV 439
LV +L+ + V A+ E V + CG I+PL+NLL + +++
Sbjct: 759 ETLVGLLTDQPEEVLVNVVGALGECCQ--ERENRVIVRKCGGIQPLVNLLVGINQALLVN 816
Query: 440 ILDAI 444
+ A+
Sbjct: 817 VTKAV 821
Score = 36.6 bits (83), Expect = 0.058
Identities = 44/200 (22%), Positives = 83/200 (41%), Gaps = 19/200 (9%)
Query: 169 SLLASPHAHISEQAVWAL----GNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLA-- 222
SLL +PH + A WAL N G + R V G ++ ++ LL + LA
Sbjct: 845 SLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFV---GGLELIVNLLKSDNKEVLASV 901
Query: 223 CGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGP 282
C + N+ NL + ++P L +L + ++ ++ AIS
Sbjct: 902 CAAITNIAKDQENLA--------VITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWG 953
Query: 283 NERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPS 342
R+ V P LV+ L +++ + +A+ + D + + GA+ +
Sbjct: 954 RNRVAFGEHKAVAP-LVRYLKSNDTNVHRATAQALYQLSEDAD-NCITMHENGAVKLLLD 1011
Query: 343 LLTNPKTNIQKEATWTMSNI 362
++ +P ++Q+ A +SNI
Sbjct: 1012 MVGSPDQDLQEAAAGCISNI 1031
>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
Length = 1363
Score = 55.1 bits (131), Expect = 2e-07
Identities = 67/307 (21%), Positives = 129/307 (42%), Gaps = 19/307 (6%)
Query: 143 ALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIK 202
+L I + + ++D G IPA I+LL S + + V L NI+ S LV +
Sbjct: 652 SLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALV-E 710
Query: 203 YGAVDPLLALLAV--PDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLL 260
G + L+ LL P++ S L ++ C NK+ + A +P+L+ LL
Sbjct: 711 AGGIPSLINLLVCDEPEVHSRCAVILYDIA-----QCENKD----VIAKYNGIPSLINLL 761
Query: 261 HHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNI 320
+ + VL + I L G V + +P L++ L + + + AI +
Sbjct: 762 NLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEV 821
Query: 321 VTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVP 380
E + GA+ +L + ++Q + + ++ + + + L
Sbjct: 822 GRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTK 881
Query: 381 FLVSVLS--KADFKTQ-KEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKII 437
+L+ +L + D K Q A+WA+ +G T++Q Y+ ++N+L + K+
Sbjct: 882 YLLKLLKAFQIDVKEQGAVALWAL----AGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQ 937
Query: 438 LVILDAI 444
V +A+
Sbjct: 938 YVGGEAV 944
Score = 35.0 bits (79), Expect = 0.17
Identities = 32/147 (21%), Positives = 66/147 (44%), Gaps = 4/147 (2%)
Query: 298 LVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATW 357
LV++L A+ ++ I D+ + ++DAG + +LL + K +Q +
Sbjct: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVG 693
Query: 358 TMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLV 417
+SNI+ + + +V G +P L+++L + + AV Y + V
Sbjct: 694 LLSNIST-HKSAVHALVEAGGIPSLINLLVCDEPEVHSRC--AVILYDIAQCENKDVIAK 750
Query: 418 HCGIIEPLMNLLTAKDTKIILVILDAI 444
+ G I L+NLL +++ +++ I
Sbjct: 751 YNG-IPSLINLLNLNIENVLVNVMNCI 776
>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 54.3 bits (129), Expect = 3e-07
Identities = 96/421 (22%), Positives = 170/421 (40%), Gaps = 60/421 (14%)
Query: 118 AGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAH 177
AG + K V+ L +T+ + + L +A G E ++ G A ++++ + +
Sbjct: 276 AGGLQKMVALLNKTNVKFLAITTD-CLQILAYGNQESKLIILASGGPQALVNIMRT---Y 331
Query: 178 ISEQAVWALGNIAGDGSVF---RDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLS 234
E+ +W + SV + +++ G + L L P ++N WTL
Sbjct: 332 TYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQR-----LVQNCLWTLR 386
Query: 235 NLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGV 294
NL + A + +E +L TLV+LL DD V+ +S LT + MV + G
Sbjct: 387 NL---SDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGG 443
Query: 295 VPQLVK--LLGASELPIVTPALRAIGNIVTGTDE----QTQVVIDAGALAVFPSLLTNPK 348
+ LV+ L I PA+ A+ ++ + E Q V + G L V LL P
Sbjct: 444 IEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYG-LPVVVKLLHPP- 501
Query: 349 TNIQKEATWTMSNITAGRQDQIQQV-VNH------GLVPFLVSVLSKADFKTQKEAVWAV 401
+ W + T G + NH G +P LV +L +A TQ+
Sbjct: 502 ------SHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGG 555
Query: 402 T--NYTSGGTVEQIV-----------YLVHCGIIEPLMNLLTAKDTKIILVILDAISNIF 448
T + G +E+IV VH I+ +N + + ++ I NI
Sbjct: 556 TQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPL----FVQLLYSPIENIQ 611
Query: 449 QAAE----KLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQ 504
+ A +L + ++ + IE G + L + NE V + +++ F + E++ Q
Sbjct: 612 RVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVL---FRMSEDKPQ 668
Query: 505 N 505
+
Sbjct: 669 D 669
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/401 (22%), Positives = 157/401 (39%), Gaps = 76/401 (18%)
Query: 38 LRKAKKDDQMLKRR--NVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQ 95
+++ + QMLK N+ ++ DDA + ++ ++ K +N E+Q+
Sbjct: 122 VQRLAEPSQMLKHAVVNLINYQDDAELATR-----------AIPELTKLLND---EDQVV 167
Query: 96 ATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQT 155
+AA + K+ + I P+ VS + RT + E+A S
Sbjct: 168 VNKAAVMVHQLSKKEASRHAIMRS--PQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHR 225
Query: 156 K---AVVDGGAIPAFISLLASP-----------------HAHISEQAVWALGNIAGDGSV 195
+ A+ G IPA + +L SP H ++ AV G + ++
Sbjct: 226 EGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVAL 285
Query: 196 FRDLVIKYGAV-DPLLALLAVPDMSS----LACG------------YLRNLTWTLS---- 234
+K+ A+ L +LA + S LA G L WT S
Sbjct: 286 LNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLK 345
Query: 235 --NLCRNKNPAPPIDAVEQILPTLVRLLHHDDP-EVLADTC-WAISYLTDGPNERIGMVV 290
++C + PA Q L LH DP + L C W + L+D ++ GM
Sbjct: 346 VLSVCSSNKPAIVEAGGMQALG-----LHLTDPSQRLVQNCLWTLRNLSDAATKQEGM-- 398
Query: 291 KTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGAL--AVFPSLLTNPK 348
G++ LV+LLG+ ++ +VT A + N+ + +V G + V L +
Sbjct: 399 -EGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDR 457
Query: 349 TNIQKEATWTMSNITAGRQ--DQIQQVVN-HGLVPFLVSVL 386
+I + A + ++T+ Q + Q V H +P +V +L
Sbjct: 458 EDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLL 498
Score = 37.4 bits (85), Expect = 0.034
Identities = 60/279 (21%), Positives = 116/279 (41%), Gaps = 15/279 (5%)
Query: 207 DPLLALLAVPDMSSLACG----YLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHH 262
D LA A+P+++ L + + L + + I Q++ +VR + +
Sbjct: 145 DAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQN 204
Query: 263 -DDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIV 321
+D E T + L+ E + + K+G +P LVK+LG+ ++ A+ + N++
Sbjct: 205 TNDVETARCTAGTLHNLSHH-REGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLL 263
Query: 322 TGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWT--MSNITAGRQDQIQQVVNHGLV 379
+ V AG L +LL KTN++ A T + + G Q+ ++ G
Sbjct: 264 LHQEGAKMAVRLAGGLQKMVALLN--KTNVKFLAITTDCLQILAYGNQESKLIILASGGP 321
Query: 380 PFLVSVLSKADFKTQKEAVWAVTNYTSGGTV--EQIVYLVHCGIIEPLMNLLTAKDTKII 437
LV+++ T ++ +W + +V +V G ++ L LT +++
Sbjct: 322 QALVNIMRT---YTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLV 378
Query: 438 LVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEAL 476
L + N+ AA K E L + + G D I +
Sbjct: 379 QNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVV 417
>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 54.3 bits (129), Expect = 3e-07
Identities = 96/421 (22%), Positives = 170/421 (40%), Gaps = 60/421 (14%)
Query: 118 AGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAH 177
AG + K V+ L +T+ + + L +A G E ++ G A ++++ + +
Sbjct: 276 AGGLQKMVALLNKTNVKFLAITTD-CLQILAYGNQESKLIILASGGPQALVNIMRT---Y 331
Query: 178 ISEQAVWALGNIAGDGSVF---RDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLS 234
E+ +W + SV + +++ G + L L P ++N WTL
Sbjct: 332 TYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQR-----LVQNCLWTLR 386
Query: 235 NLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGV 294
NL + A + +E +L TLV+LL DD V+ +S LT + MV + G
Sbjct: 387 NL---SDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGG 443
Query: 295 VPQLVK--LLGASELPIVTPALRAIGNIVTGTDE----QTQVVIDAGALAVFPSLLTNPK 348
+ LV+ L I PA+ A+ ++ + E Q V + G L V LL P
Sbjct: 444 IEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYG-LPVVVKLLHPP- 501
Query: 349 TNIQKEATWTMSNITAGRQDQIQQV-VNH------GLVPFLVSVLSKADFKTQKEAVWAV 401
+ W + T G + NH G +P LV +L +A TQ+
Sbjct: 502 ------SHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGG 555
Query: 402 T--NYTSGGTVEQIV-----------YLVHCGIIEPLMNLLTAKDTKIILVILDAISNIF 448
T + G +E+IV VH I+ +N + + ++ I NI
Sbjct: 556 TQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPL----FVQLLYSPIENIQ 611
Query: 449 QAAE----KLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQ 504
+ A +L + ++ + IE G + L + NE V + +++ F + E++ Q
Sbjct: 612 RVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVL---FRMSEDKPQ 668
Query: 505 N 505
+
Sbjct: 669 D 669
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/401 (22%), Positives = 157/401 (39%), Gaps = 76/401 (18%)
Query: 38 LRKAKKDDQMLKRR--NVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQ 95
+++ + QMLK N+ ++ DDA + ++ ++ K +N E+Q+
Sbjct: 122 VQRLAEPSQMLKHAVVNLINYQDDAELATR-----------AIPELTKLLND---EDQVV 167
Query: 96 ATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQT 155
+AA + K+ + I P+ VS + RT + E+A S
Sbjct: 168 VNKAAVMVHQLSKKEASRHAIMRS--PQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHR 225
Query: 156 K---AVVDGGAIPAFISLLASP-----------------HAHISEQAVWALGNIAGDGSV 195
+ A+ G IPA + +L SP H ++ AV G + ++
Sbjct: 226 EGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVAL 285
Query: 196 FRDLVIKYGAV-DPLLALLAVPDMSS----LACG------------YLRNLTWTLS---- 234
+K+ A+ L +LA + S LA G L WT S
Sbjct: 286 LNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLK 345
Query: 235 --NLCRNKNPAPPIDAVEQILPTLVRLLHHDDP-EVLADTC-WAISYLTDGPNERIGMVV 290
++C + PA Q L LH DP + L C W + L+D ++ GM
Sbjct: 346 VLSVCSSNKPAIVEAGGMQALG-----LHLTDPSQRLVQNCLWTLRNLSDAATKQEGM-- 398
Query: 291 KTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGAL--AVFPSLLTNPK 348
G++ LV+LLG+ ++ +VT A + N+ + +V G + V L +
Sbjct: 399 -EGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDR 457
Query: 349 TNIQKEATWTMSNITAGRQ--DQIQQVVN-HGLVPFLVSVL 386
+I + A + ++T+ Q + Q V H +P +V +L
Sbjct: 458 EDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLL 498
Score = 37.4 bits (85), Expect = 0.034
Identities = 60/279 (21%), Positives = 116/279 (41%), Gaps = 15/279 (5%)
Query: 207 DPLLALLAVPDMSSLACG----YLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHH 262
D LA A+P+++ L + + L + + I Q++ +VR + +
Sbjct: 145 DAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQN 204
Query: 263 -DDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIV 321
+D E T + L+ E + + K+G +P LVK+LG+ ++ A+ + N++
Sbjct: 205 TNDVETARCTAGTLHNLSHH-REGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLL 263
Query: 322 TGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWT--MSNITAGRQDQIQQVVNHGLV 379
+ V AG L +LL KTN++ A T + + G Q+ ++ G
Sbjct: 264 LHQEGAKMAVRLAGGLQKMVALLN--KTNVKFLAITTDCLQILAYGNQESKLIILASGGP 321
Query: 380 PFLVSVLSKADFKTQKEAVWAVTNYTSGGTV--EQIVYLVHCGIIEPLMNLLTAKDTKII 437
LV+++ T ++ +W + +V +V G ++ L LT +++
Sbjct: 322 QALVNIMRT---YTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLV 378
Query: 438 LVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEAL 476
L + N+ AA K E L + + G D I +
Sbjct: 379 QNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVV 417
>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
[Homo sapiens]
Length = 781
Score = 54.3 bits (129), Expect = 3e-07
Identities = 96/421 (22%), Positives = 170/421 (40%), Gaps = 60/421 (14%)
Query: 118 AGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAH 177
AG + K V+ L +T+ + + L +A G E ++ G A ++++ + +
Sbjct: 276 AGGLQKMVALLNKTNVKFLAITTD-CLQILAYGNQESKLIILASGGPQALVNIMRT---Y 331
Query: 178 ISEQAVWALGNIAGDGSVF---RDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLS 234
E+ +W + SV + +++ G + L L P ++N WTL
Sbjct: 332 TYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQR-----LVQNCLWTLR 386
Query: 235 NLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGV 294
NL + A + +E +L TLV+LL DD V+ +S LT + MV + G
Sbjct: 387 NL---SDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGG 443
Query: 295 VPQLVK--LLGASELPIVTPALRAIGNIVTGTDE----QTQVVIDAGALAVFPSLLTNPK 348
+ LV+ L I PA+ A+ ++ + E Q V + G L V LL P
Sbjct: 444 IEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYG-LPVVVKLLHPP- 501
Query: 349 TNIQKEATWTMSNITAGRQDQIQQV-VNH------GLVPFLVSVLSKADFKTQKEAVWAV 401
+ W + T G + NH G +P LV +L +A TQ+
Sbjct: 502 ------SHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGG 555
Query: 402 T--NYTSGGTVEQIV-----------YLVHCGIIEPLMNLLTAKDTKIILVILDAISNIF 448
T + G +E+IV VH I+ +N + + ++ I NI
Sbjct: 556 TQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPL----FVQLLYSPIENIQ 611
Query: 449 QAAE----KLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQ 504
+ A +L + ++ + IE G + L + NE V + +++ F + E++ Q
Sbjct: 612 RVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVL---FRMSEDKPQ 668
Query: 505 N 505
+
Sbjct: 669 D 669
Score = 47.4 bits (111), Expect = 3e-05
Identities = 89/401 (22%), Positives = 157/401 (39%), Gaps = 76/401 (18%)
Query: 38 LRKAKKDDQMLKRR--NVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQ 95
+++ + QMLK N+ ++ DDA + ++ ++ K +N E+Q+
Sbjct: 122 VQRLAEPSQMLKHAVVNLINYQDDAELATR-----------AIPELTKLLND---EDQVV 167
Query: 96 ATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQT 155
+AA + K+ + I P+ VS + RT + E+A S
Sbjct: 168 VNKAAVMVHQLSKKEASRHAIMRS--PQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHR 225
Query: 156 K---AVVDGGAIPAFISLLASP-----------------HAHISEQAVWALGNIAGDGSV 195
+ A+ G IPA + +L SP H ++ AV G + ++
Sbjct: 226 EGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVAL 285
Query: 196 FRDLVIKYGAV-DPLLALLAVPDMSS----LACG------------YLRNLTWTLS---- 234
+K+ A+ L +LA + S LA G L WT S
Sbjct: 286 LNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLK 345
Query: 235 --NLCRNKNPAPPIDAVEQILPTLVRLLHHDDP-EVLADTC-WAISYLTDGPNERIGMVV 290
++C + PA Q L LH DP + L C W + L+D ++ GM
Sbjct: 346 VLSVCSSNKPAIVEAGGMQALG-----LHLTDPSQRLVQNCLWTLRNLSDAATKQEGM-- 398
Query: 291 KTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGAL--AVFPSLLTNPK 348
G++ LV+LLG+ ++ +VT A + N+ + +V G + V L +
Sbjct: 399 -EGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDR 457
Query: 349 TNIQKEATWTMSNITAGRQ--DQIQQVVN-HGLVPFLVSVL 386
+I + A + ++T+ Q + Q V H +P +V +L
Sbjct: 458 EDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLL 498
Score = 37.4 bits (85), Expect = 0.034
Identities = 60/279 (21%), Positives = 116/279 (41%), Gaps = 15/279 (5%)
Query: 207 DPLLALLAVPDMSSLACG----YLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHH 262
D LA A+P+++ L + + L + + I Q++ +VR + +
Sbjct: 145 DAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQN 204
Query: 263 -DDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIV 321
+D E T + L+ E + + K+G +P LVK+LG+ ++ A+ + N++
Sbjct: 205 TNDVETARCTAGTLHNLSHH-REGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLL 263
Query: 322 TGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWT--MSNITAGRQDQIQQVVNHGLV 379
+ V AG L +LL KTN++ A T + + G Q+ ++ G
Sbjct: 264 LHQEGAKMAVRLAGGLQKMVALLN--KTNVKFLAITTDCLQILAYGNQESKLIILASGGP 321
Query: 380 PFLVSVLSKADFKTQKEAVWAVTNYTSGGTV--EQIVYLVHCGIIEPLMNLLTAKDTKII 437
LV+++ T ++ +W + +V +V G ++ L LT +++
Sbjct: 322 QALVNIMRT---YTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLV 378
Query: 438 LVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEAL 476
L + N+ AA K E L + + G D I +
Sbjct: 379 QNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVV 417
>gi|155030200 RAP1, GTP-GDP dissociation stimulator 1 isoform 5
[Homo sapiens]
Length = 558
Score = 53.5 bits (127), Expect = 5e-07
Identities = 81/389 (20%), Positives = 162/389 (41%), Gaps = 34/389 (8%)
Query: 104 LSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGA 163
L++ + I +G++ F S L T S + + A + +A + V D G
Sbjct: 34 LAQNNTETSEKIQASGILQLFASLL--TPQSSCKAKVANIIAEVAKNEFMRIPCV-DAGL 90
Query: 164 IPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLAC 223
I + LL S + Q ALGNI D + +I G + L+ LL + ++
Sbjct: 91 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALT 150
Query: 224 GYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPN 283
L+ L +K + E+++ + + HD E++ + ++ N
Sbjct: 151 EMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA-----EN 205
Query: 284 ERIGM-VVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGT---------DEQTQVVID 333
+ I + +V+ G+V L++++ + + + I + TG+ DE Q + +
Sbjct: 206 DAIKLQLVEAGLVECLLEIV---QQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFE 262
Query: 334 AGALAVFPSLLT-NPKTNIQKEATWTMSNITAGRQD-QIQQVVNHGLVPFLVSVLSK--- 388
G +VF +L+ P N Q + ++ R D +V++G+V L+ +L +
Sbjct: 263 GGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVE 322
Query: 389 -ADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNI 447
+ Q A+ A+ N V ++ G+ E ++ L ++ + +L + +
Sbjct: 323 DGNVTVQHAALSALRNLAI--PVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRML 380
Query: 448 F----QAAEKLGETEKL-SIMIEECGGLD 471
+AAE+LG+ KL ++E C D
Sbjct: 381 IDAQAEAAEQLGKNVKLVERLVEWCEAKD 409
>gi|155030198 RAP1, GTP-GDP dissociation stimulator 1 isoform 4
[Homo sapiens]
Length = 559
Score = 53.5 bits (127), Expect = 5e-07
Identities = 81/389 (20%), Positives = 162/389 (41%), Gaps = 34/389 (8%)
Query: 104 LSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGA 163
L++ + I +G++ F S L T S + + A + +A + V D G
Sbjct: 35 LAQNNTETSEKIQASGILQLFASLL--TPQSSCKAKVANIIAEVAKNEFMRIPCV-DAGL 91
Query: 164 IPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLAC 223
I + LL S + Q ALGNI D + +I G + L+ LL + ++
Sbjct: 92 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHSLQAQLINMGVIPTLVKLLGIHCQNAALT 151
Query: 224 GYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPN 283
L+ L +K + E+++ + + HD E++ + ++ N
Sbjct: 152 EMCLVAFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA-----EN 206
Query: 284 ERIGM-VVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGT---------DEQTQVVID 333
+ I + +V+ G+V L++++ + + + I + TG+ DE Q + +
Sbjct: 207 DAIKLQLVEAGLVECLLEIV---QQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFE 263
Query: 334 AGALAVFPSLLT-NPKTNIQKEATWTMSNITAGRQD-QIQQVVNHGLVPFLVSVLSK--- 388
G +VF +L+ P N Q + ++ R D +V++G+V L+ +L +
Sbjct: 264 GGKGSVFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVE 323
Query: 389 -ADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNI 447
+ Q A+ A+ N V ++ G+ E ++ L ++ + +L + +
Sbjct: 324 DGNVTVQHAALSALRNLAI--PVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRML 381
Query: 448 F----QAAEKLGETEKL-SIMIEECGGLD 471
+AAE+LG+ KL ++E C D
Sbjct: 382 IDAQAEAAEQLGKNVKLVERLVEWCEAKD 410
>gi|4504811 junction plakoglobin [Homo sapiens]
Length = 745
Score = 51.2 bits (121), Expect = 2e-06
Identities = 94/481 (19%), Positives = 186/481 (38%), Gaps = 79/481 (16%)
Query: 21 GKDSTEMRRRRIEVNV-ELRKAKKDDQMLKRRNVS--SFPDDATSPLQENRNNQGTVNWS 77
G+DS+ + ++E L++ + Q+LK V ++ DDA L + T +
Sbjct: 95 GEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAE--LATRALPELTKLLN 152
Query: 78 VDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQ 137
+D V ++ + NQL +A+R+ L P+ V+ + RT +
Sbjct: 153 DEDPVVVTKAAMIVNQLSKKEASRRALMGS--------------PQLVAAVVRTMQNTSD 198
Query: 138 FESAWALTNIASGTSEQTK---AVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGS 194
++A T+I S + A+ G IPA + +L+SP + A+ L N+
Sbjct: 199 LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNL----- 253
Query: 195 VFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILP 254
L+ + GA K D +++++P
Sbjct: 254 ----LLYQEGA----------------------------------KMAVRLADGLQKMVP 275
Query: 255 TLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPAL 314
LL+ ++P+ LA T + L G E +++ G LV+++ +
Sbjct: 276 ----LLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTT 331
Query: 315 RAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT--AGRQDQIQQ 372
+ +++ +++AG + LT+ + + WT+ N++ A +Q+ ++
Sbjct: 332 SRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLES 391
Query: 373 VVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAK 432
V+ LV+ LS D A ++N T + + + + G+ + +L A
Sbjct: 392 VLK-----ILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAG 446
Query: 433 DTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENE-SVYKASLSL 491
D I A+ + + E E + G+ I L N N+ + KA++ L
Sbjct: 447 DKDDITE--PAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGL 504
Query: 492 I 492
I
Sbjct: 505 I 505
Score = 38.9 bits (89), Expect = 0.012
Identities = 44/176 (25%), Positives = 77/176 (43%), Gaps = 26/176 (14%)
Query: 157 AVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLAL---- 212
A+V+ G + A L S + + +W L N++ D+ K ++ +L +
Sbjct: 347 AIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-------DVATKQEGLESVLKILVNQ 399
Query: 213 LAVPDMSSLAC--GYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLAD 270
L+V D++ L C G L NLT N +NK VE ++ ++R DD +
Sbjct: 400 LSVDDVNVLTCATGTLSNLT---CNNSKNKTLVTQNSGVEALIHAILRAGDKDD--ITEP 454
Query: 271 TCWAISYLTDGPNERIGMVVKTGV-----VPQLVKLLG-ASELPIVTPALRAIGNI 320
A+ +LT E + + V +P +VKLL ++ P+V + I N+
Sbjct: 455 AVCALRHLTSRHPE--AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNL 508
>gi|12056468 junction plakoglobin [Homo sapiens]
Length = 745
Score = 51.2 bits (121), Expect = 2e-06
Identities = 94/481 (19%), Positives = 186/481 (38%), Gaps = 79/481 (16%)
Query: 21 GKDSTEMRRRRIEVNV-ELRKAKKDDQMLKRRNVS--SFPDDATSPLQENRNNQGTVNWS 77
G+DS+ + ++E L++ + Q+LK V ++ DDA L + T +
Sbjct: 95 GEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAE--LATRALPELTKLLN 152
Query: 78 VDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQ 137
+D V ++ + NQL +A+R+ L P+ V+ + RT +
Sbjct: 153 DEDPVVVTKAAMIVNQLSKKEASRRALMGS--------------PQLVAAVVRTMQNTSD 198
Query: 138 FESAWALTNIASGTSEQTK---AVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGS 194
++A T+I S + A+ G IPA + +L+SP + A+ L N+
Sbjct: 199 LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNL----- 253
Query: 195 VFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILP 254
L+ + GA K D +++++P
Sbjct: 254 ----LLYQEGA----------------------------------KMAVRLADGLQKMVP 275
Query: 255 TLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPAL 314
LL+ ++P+ LA T + L G E +++ G LV+++ +
Sbjct: 276 ----LLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTT 331
Query: 315 RAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT--AGRQDQIQQ 372
+ +++ +++AG + LT+ + + WT+ N++ A +Q+ ++
Sbjct: 332 SRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLES 391
Query: 373 VVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAK 432
V+ LV+ LS D A ++N T + + + + G+ + +L A
Sbjct: 392 VLK-----ILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAG 446
Query: 433 DTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENE-SVYKASLSL 491
D I A+ + + E E + G+ I L N N+ + KA++ L
Sbjct: 447 DKDDITE--PAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGL 504
Query: 492 I 492
I
Sbjct: 505 I 505
Score = 38.9 bits (89), Expect = 0.012
Identities = 44/176 (25%), Positives = 77/176 (43%), Gaps = 26/176 (14%)
Query: 157 AVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLAL---- 212
A+V+ G + A L S + + +W L N++ D+ K ++ +L +
Sbjct: 347 AIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-------DVATKQEGLESVLKILVNQ 399
Query: 213 LAVPDMSSLAC--GYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLAD 270
L+V D++ L C G L NLT N +NK VE ++ ++R DD +
Sbjct: 400 LSVDDVNVLTCATGTLSNLT---CNNSKNKTLVTQNSGVEALIHAILRAGDKDD--ITEP 454
Query: 271 TCWAISYLTDGPNERIGMVVKTGV-----VPQLVKLLG-ASELPIVTPALRAIGNI 320
A+ +LT E + + V +P +VKLL ++ P+V + I N+
Sbjct: 455 AVCALRHLTSRHPE--AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNL 508
>gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]
Length = 659
Score = 50.4 bits (119), Expect = 4e-06
Identities = 63/301 (20%), Positives = 126/301 (41%), Gaps = 27/301 (8%)
Query: 78 VDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQ 137
+D IV G++ S+V+ +L A + L +Q A P D I
Sbjct: 372 MDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPD--EIL 429
Query: 138 FESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA--GDGSV 195
++ L N+ S + +++ GA+ L S + + +WAL N+A + +
Sbjct: 430 VVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKI 489
Query: 196 FRDLVIKYGAVDPLLALLAVPDMSSL--ACGYLRNLTWTLSNLCRNKNPAPPIDAV---- 249
D +++ + + L LL+ D++ L G LRNL T P ID +
Sbjct: 490 KAD-ILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLST----------RPHIDKIMSTH 538
Query: 250 -EQILPTLVRLLHHD-DPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASEL 307
+QI+ + +L + + EV T ++ + DG + ++ ++ ++ +G S +
Sbjct: 539 GKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHV 598
Query: 308 PIVTPALRAIGNIV----TGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT 363
+ A+ I N++ G+ E+ + D G + + L +P +N+ +A +
Sbjct: 599 KLQLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKMALQQYL 658
Query: 364 A 364
A
Sbjct: 659 A 659
Score = 38.1 bits (87), Expect = 0.020
Identities = 30/103 (29%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 114 NIIRAGLIPKFVSFLGR-TDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLA 172
N+I G +P+ + L + T + ++ E A L ++A GT K+++D IPA + L
Sbjct: 42 NLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLL 101
Query: 173 SPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDP-LLALLA 214
SP E + L I +L+ V P L+ALL+
Sbjct: 102 SPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLS 144
Score = 33.5 bits (75), Expect = 0.49
Identities = 28/115 (24%), Positives = 56/115 (48%), Gaps = 4/115 (3%)
Query: 319 NIVTGTDEQTQVVIDAGALAVFPSLLTNP--KTNIQKEATWTMSNITAGRQDQIQQVVNH 376
N V G ++Q +I GA+ LL T ++ E + ++ G ++ ++ +++
Sbjct: 31 NAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDC 90
Query: 377 GLVPFLVSVLSKADFKTQKEAVWAV-TNYTSGGTVEQIVYLVHCGIIEPLMNLLT 430
++P L+ L D K + + + T +TS T E+++Y +I LM LL+
Sbjct: 91 HIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLY-TDATVIPHLMALLS 144
>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
Length = 872
Score = 47.4 bits (111), Expect = 3e-05
Identities = 35/142 (24%), Positives = 68/142 (47%), Gaps = 3/142 (2%)
Query: 295 VPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKE 354
+PQL++LL + + A A+ N+ T +A + +LL++ +
Sbjct: 358 IPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLLSSKRDGAIAN 417
Query: 355 ATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIV 414
A ++N+ A ++ + NH ++ ++S L A+ Q +A AVT + VE
Sbjct: 418 AATVLTNM-AMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVT--ATACDVEART 474
Query: 415 YLVHCGIIEPLMNLLTAKDTKI 436
L + G +EPL+ LL +K+ ++
Sbjct: 475 ELRNSGGLEPLVELLRSKNDEV 496
Score = 46.6 bits (109), Expect = 6e-05
Identities = 60/257 (23%), Positives = 115/257 (44%), Gaps = 19/257 (7%)
Query: 244 PPIDAVEQIL------PTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQ 297
PP D + ++ T+V +L+ + E+LA C AI E +++ G V
Sbjct: 12 PPKDVFDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEP 71
Query: 298 LVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGAL-AVFPSLLTNPKTNIQKEAT 356
L KLL E IV I I+ ++ +++ + + +V L + I + A+
Sbjct: 72 LTKLL-THEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFAS 130
Query: 357 WTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYL 416
++N++A ++ Q+ HG + L+ +LS D +K ++ + N + L
Sbjct: 131 LCLANMSAEYTSKV-QIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQ--DFQCRAKL 187
Query: 417 VHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDK-IEA 475
I P+++LL ++ I L+ L + I A +K T M+ + GLD I+
Sbjct: 188 QELNAIPPILDLLKSEYPVIQLLALKTLGVI--ANDKESRT-----MLRDNQGLDHLIKI 240
Query: 476 LQNHENESVYKASLSLI 492
L+ E ++ +L++I
Sbjct: 241 LETKELNDLHIEALAVI 257
Score = 35.0 bits (79), Expect = 0.17
Identities = 59/272 (21%), Positives = 101/272 (37%), Gaps = 39/272 (14%)
Query: 168 ISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDM-----SSLA 222
+ +L SP I +A A+ A G + +++ GAV+PL LL D +++
Sbjct: 31 VLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNATMI 90
Query: 223 CGYLRN---------------------------LTWTLSNLCRNKNPAPPIDAVEQI--- 252
G L + + ++LC A V+
Sbjct: 91 FGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYTSKVQIFEHG 150
Query: 253 -LPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIV- 310
L L+RLL DP+V ++ I L R + + +P ++ LL SE P++
Sbjct: 151 GLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCR-AKLQELNAIPPILDLL-KSEYPVIQ 208
Query: 311 TPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI 370
AL+ +G I + +T + + G + L T ++ EA ++N +
Sbjct: 209 LLALKTLGVIANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMV 268
Query: 371 QQVVNHGLVPFLVSVLSKADFKTQKEAVWAVT 402
Q GL L + QK A A+T
Sbjct: 269 QIQQTGGLKKLLSFAENSTIPDIQKNAAKAIT 300
Score = 33.1 bits (74), Expect = 0.64
Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 4/132 (3%)
Query: 79 DDIVKGINSSNVENQLQATQAARKLLSREKQPPID-NIIRAGLIPKFVSFLGRTDCSPIQ 137
D I IN + + AA L + Q P+ NI ++ +S L R+ + +Q
Sbjct: 398 DGIDPLINLLSSKRDGAIANAATVLTNMAMQEPLRLNIQNHDIMHAIISPL-RSANTVVQ 456
Query: 138 FESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFR 197
++A A+T A +T+ GG P + LL S + + + A WA+ AGD
Sbjct: 457 SKAALAVTATACDVEARTELRNSGGLEP-LVELLRSKNDEVRKHASWAVMVCAGDELTAN 515
Query: 198 DLVIKYGAVDPL 209
+L + GA+D L
Sbjct: 516 EL-CRLGALDIL 526
>gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]
Length = 1992
Score = 47.0 bits (110), Expect = 4e-05
Identities = 56/242 (23%), Positives = 97/242 (40%), Gaps = 15/242 (6%)
Query: 81 IVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFES 140
+++G+ +S+ QLQA +LL + + ++P ++ L I +
Sbjct: 442 LLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHA 501
Query: 141 AWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHA-HISEQAVWALGNIAGDGSVFRDL 199
ALT + + VVD AIP F+ L ++EQA+ AL ++ S + +
Sbjct: 502 CRALTYMMEALPRSSAVVVD--AIPVFLEKLQVIQCIDVAEQALTALEMLSRRHS--KAI 557
Query: 200 VIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRL 259
+ G D LL L + RN +N C++ P V LP L +
Sbjct: 558 LQAGGLADCLLYL------EFFSINAQRNALAIAANCCQSITP-DEFHFVADSLPLLTQR 610
Query: 260 LHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGN 319
L H D + + TC + L D ++ + V L +L +VTP + + G
Sbjct: 611 LTHQDKKSVESTCLCFARLVDNFQHEENLLQQ---VASKDLLTNVQQLLVVTPPILSSGM 667
Query: 320 IV 321
+
Sbjct: 668 FI 669
>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
[Homo sapiens]
Length = 607
Score = 44.3 bits (103), Expect = 3e-04
Identities = 96/438 (21%), Positives = 168/438 (38%), Gaps = 84/438 (19%)
Query: 104 LSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGA 163
L++ + I +G++ F S L T S + + A + +A + V D G
Sbjct: 35 LAQNNTETSEKIQASGILQLFASLL--TPQSSCKAKVANIIAEVAKNEFMRIPCV-DAGL 91
Query: 164 IPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYG----AVDPLLALLAVPD-- 217
I + LL S + Q ALGNI D R V + G +D L +L ++ D
Sbjct: 92 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151
Query: 218 ---MSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQ-ILPTLVRLLH-HDDPEVLADTC 272
+ ++ CG L N + N+N + + ++PTLV+LL H L + C
Sbjct: 152 NEKLLTVFCGMLMNYS--------NENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMC 203
Query: 273 W-AISYLTDGPNERIGMVVKTGVVPQLVKLL----------------------GASELPI 309
A L + + + T + +LVKL A +L +
Sbjct: 204 LVAFGNLAELESSK-EQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQL 262
Query: 310 VTPAL-----------------RAIGNIVTGT---------DEQTQVVIDAGALAVFPSL 343
V L I + TG+ DE Q + + G +VF +
Sbjct: 263 VEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRV 322
Query: 344 LT-NPKTNIQKEATWTMSNITAGRQD-QIQQVVNHGLVPFLVSVLSK----ADFKTQKEA 397
L+ P N Q + ++ R D +V++G+V L+ +L + + Q A
Sbjct: 323 LSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAA 382
Query: 398 VWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIF---QAAEKL 454
+ A+ N V ++ G+ E ++ L ++ + +L + + +AAE+L
Sbjct: 383 LSALRNLAI--PVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQEAAEQL 440
Query: 455 GETEKL-SIMIEECGGLD 471
G+ KL ++E C D
Sbjct: 441 GKNVKLVERLVEWCEAKD 458
>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
[Homo sapiens]
Length = 607
Score = 43.9 bits (102), Expect = 4e-04
Identities = 96/439 (21%), Positives = 168/439 (38%), Gaps = 85/439 (19%)
Query: 104 LSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGA 163
L++ + I +G++ F S L T S + + A + +A + V D G
Sbjct: 34 LAQNNTETSEKIQASGILQLFASLL--TPQSSCKAKVANIIAEVAKNEFMRIPCV-DAGL 90
Query: 164 IPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYG----AVDPLLALLAVPD-- 217
I + LL S + Q ALGNI D R V + G +D L +L ++ D
Sbjct: 91 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 150
Query: 218 ---MSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQ-ILPTLVRLLH-HDDPEVLADTC 272
+ ++ CG L N + N+N + + ++PTLV+LL H L + C
Sbjct: 151 NEKLLTVFCGMLMNYS--------NENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMC 202
Query: 273 W-AISYLTDGPNERIGMVVKTGVVPQLVKLL----------------------GASELPI 309
A L + + + T + +LVKL A +L +
Sbjct: 203 LVAFGNLAELESSK-EQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQL 261
Query: 310 VTPAL-----------------RAIGNIVTGT---------DEQTQVVIDAGALAVFPSL 343
V L I + TG+ DE Q + + G +VF +
Sbjct: 262 VEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRV 321
Query: 344 LT-NPKTNIQKEATWTMSNITAGRQD-QIQQVVNHGLVPFLVSVLSK----ADFKTQKEA 397
L+ P N Q + ++ R D +V++G+V L+ +L + + Q A
Sbjct: 322 LSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAA 381
Query: 398 VWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIF----QAAEK 453
+ A+ N V ++ G+ E ++ L ++ + +L + + +AAE+
Sbjct: 382 LSALRNLAI--PVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQ 439
Query: 454 LGETEKL-SIMIEECGGLD 471
LG+ KL ++E C D
Sbjct: 440 LGKNVKLVERLVEWCEAKD 458
>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
[Homo sapiens]
Length = 608
Score = 43.9 bits (102), Expect = 4e-04
Identities = 96/439 (21%), Positives = 168/439 (38%), Gaps = 85/439 (19%)
Query: 104 LSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGA 163
L++ + I +G++ F S L T S + + A + +A + V D G
Sbjct: 35 LAQNNTETSEKIQASGILQLFASLL--TPQSSCKAKVANIIAEVAKNEFMRIPCV-DAGL 91
Query: 164 IPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYG----AVDPLLALLAVPD-- 217
I + LL S + Q ALGNI D R V + G +D L +L ++ D
Sbjct: 92 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151
Query: 218 ---MSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQ-ILPTLVRLLH-HDDPEVLADTC 272
+ ++ CG L N + N+N + + ++PTLV+LL H L + C
Sbjct: 152 NEKLLTVFCGMLMNYS--------NENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMC 203
Query: 273 W-AISYLTDGPNERIGMVVKTGVVPQLVKLL----------------------GASELPI 309
A L + + + T + +LVKL A +L +
Sbjct: 204 LVAFGNLAELESSK-EQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLAENDAIKLQL 262
Query: 310 VTPAL-----------------RAIGNIVTGT---------DEQTQVVIDAGALAVFPSL 343
V L I + TG+ DE Q + + G +VF +
Sbjct: 263 VEAGLVECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRV 322
Query: 344 LT-NPKTNIQKEATWTMSNITAGRQD-QIQQVVNHGLVPFLVSVLSK----ADFKTQKEA 397
L+ P N Q + ++ R D +V++G+V L+ +L + + Q A
Sbjct: 323 LSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRHVEDGNVTVQHAA 382
Query: 398 VWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIF----QAAEK 453
+ A+ N V ++ G+ E ++ L ++ + +L + + +AAE+
Sbjct: 383 LSALRNLAI--PVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQ 440
Query: 454 LGETEKL-SIMIEECGGLD 471
LG+ KL ++E C D
Sbjct: 441 LGKNVKLVERLVEWCEAKD 459
>gi|53829376 plakophilin 4 isoform b [Homo sapiens]
Length = 1149
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/141 (26%), Positives = 63/141 (44%), Gaps = 16/141 (11%)
Query: 253 LPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTP 312
LP ++ +L H P V A+ + +L G N+ V + G + LV LL L +
Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589
Query: 313 ALRAIGNIVTG--TDEQTQVVIDAGALAVFPSLLTNPKTNIQKE-------ATWTMSNIT 363
A A+ N+V G TDE + + G + P+LL + +I E W +S+
Sbjct: 590 ACGALRNLVFGKSTDENKIAMKNVGGI---PALLRLLRKSIDAEVRELVTGVLWNLSSCD 646
Query: 364 AGR----QDQIQQVVNHGLVP 380
A + +D + + N +VP
Sbjct: 647 AVKMTIIRDALSTLTNTVIVP 667
>gi|53829374 plakophilin 4 isoform a [Homo sapiens]
Length = 1192
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/141 (26%), Positives = 63/141 (44%), Gaps = 16/141 (11%)
Query: 253 LPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTP 312
LP ++ +L H P V A+ + +L G N+ V + G + LV LL L +
Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589
Query: 313 ALRAIGNIVTG--TDEQTQVVIDAGALAVFPSLLTNPKTNIQKE-------ATWTMSNIT 363
A A+ N+V G TDE + + G + P+LL + +I E W +S+
Sbjct: 590 ACGALRNLVFGKSTDENKIAMKNVGGI---PALLRLLRKSIDAEVRELVTGVLWNLSSCD 646
Query: 364 AGR----QDQIQQVVNHGLVP 380
A + +D + + N +VP
Sbjct: 647 AVKMTIIRDALSTLTNTVIVP 667
>gi|47458043 armadillo repeat containing 8 isoform 3 [Homo sapiens]
Length = 385
Score = 38.1 bits (87), Expect = 0.020
Identities = 30/103 (29%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 114 NIIRAGLIPKFVSFLGR-TDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLA 172
N+I G +P+ + L + T + ++ E A L ++A GT K+++D IPA + L
Sbjct: 42 NLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLL 101
Query: 173 SPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDP-LLALLA 214
SP E + L I +L+ V P L+ALL+
Sbjct: 102 SPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLS 144
Score = 33.5 bits (75), Expect = 0.49
Identities = 28/115 (24%), Positives = 56/115 (48%), Gaps = 4/115 (3%)
Query: 319 NIVTGTDEQTQVVIDAGALAVFPSLLTNP--KTNIQKEATWTMSNITAGRQDQIQQVVNH 376
N V G ++Q +I GA+ LL T ++ E + ++ G ++ ++ +++
Sbjct: 31 NAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDC 90
Query: 377 GLVPFLVSVLSKADFKTQKEAVWAV-TNYTSGGTVEQIVYLVHCGIIEPLMNLLT 430
++P L+ L D K + + + T +TS T E+++Y +I LM LL+
Sbjct: 91 HIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLY-TDATVIPHLMALLS 144
>gi|47458045 armadillo repeat containing 8 isoform 1 [Homo sapiens]
Length = 385
Score = 38.1 bits (87), Expect = 0.020
Identities = 30/103 (29%), Positives = 49/103 (47%), Gaps = 2/103 (1%)
Query: 114 NIIRAGLIPKFVSFLGR-TDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLA 172
N+I G +P+ + L + T + ++ E A L ++A GT K+++D IPA + L
Sbjct: 42 NLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLL 101
Query: 173 SPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDP-LLALLA 214
SP E + L I +L+ V P L+ALL+
Sbjct: 102 SPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLS 144
Score = 33.5 bits (75), Expect = 0.49
Identities = 28/115 (24%), Positives = 56/115 (48%), Gaps = 4/115 (3%)
Query: 319 NIVTGTDEQTQVVIDAGALAVFPSLLTNP--KTNIQKEATWTMSNITAGRQDQIQQVVNH 376
N V G ++Q +I GA+ LL T ++ E + ++ G ++ ++ +++
Sbjct: 31 NAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDC 90
Query: 377 GLVPFLVSVLSKADFKTQKEAVWAV-TNYTSGGTVEQIVYLVHCGIIEPLMNLLT 430
++P L+ L D K + + + T +TS T E+++Y +I LM LL+
Sbjct: 91 HIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLY-TDATVIPHLMALLS 144
>gi|4826952 proteasome 26S non-ATPase subunit 5 [Homo sapiens]
Length = 504
Score = 36.6 bits (83), Expect = 0.058
Identities = 46/223 (20%), Positives = 89/223 (39%), Gaps = 12/223 (5%)
Query: 216 PDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAI 275
P S L + T +S L R P+ + L R L H D V T I
Sbjct: 48 PLFSLLNENHREKTTLCVSILERLLQAMEPVHVARNLRVDLQRGLIHPDDSVKILTLSQI 107
Query: 276 SYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAG 335
+ + + ++ ++ Q+V +G L + A++++ I + T + + ++
Sbjct: 108 GRIVENSDAVTEILNNAELLKQIVYCIGGENLSVAKAAIKSLSRI-SLTQAGLEALFESN 166
Query: 336 ALAVFPSLLTNPKTN--IQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKT 393
L S++ KTN ++ + I++ + + GLV L+ L+ D
Sbjct: 167 LLDDLKSVM---KTNDIVRYRVYELIIEISSVSPESLNYCTTSGLVTQLLRELTGEDVLV 223
Query: 394 QKEAVWAVTN--YTSGGTVEQIVYLVHCGIIEPLMNLLTAKDT 434
+ + VT+ YT G YL G+I+ + N++ D+
Sbjct: 224 RATCIEMVTSLAYTHHGR----QYLAQEGVIDQISNIIVGADS 262
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,830,135
Number of Sequences: 37866
Number of extensions: 760775
Number of successful extensions: 2644
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 2341
Number of HSP's gapped (non-prelim): 146
length of query: 529
length of database: 18,247,518
effective HSP length: 107
effective length of query: 422
effective length of database: 14,195,856
effective search space: 5990651232
effective search space used: 5990651232
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.