BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4504811 junction plakoglobin [Homo sapiens] (745 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4504811 junction plakoglobin [Homo sapiens] 1469 0.0 gi|12056468 junction plakoglobin [Homo sapiens] 1469 0.0 gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD... 952 0.0 gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD... 952 0.0 gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ... 952 0.0 gi|31657114 armadillo repeat containing 4 [Homo sapiens] 77 8e-14 gi|189409124 armadillo repeat containing 3 [Homo sapiens] 76 1e-13 gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 57 6e-08 gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens] 53 1e-06 gi|11034811 catenin (cadherin-associated protein), delta 2 (neur... 52 2e-06 gi|4504897 karyopherin alpha 2 [Homo sapiens] 51 3e-06 gi|4502247 armadillo repeat protein [Homo sapiens] 51 4e-06 gi|53829376 plakophilin 4 isoform b [Homo sapiens] 46 1e-04 gi|53829374 plakophilin 4 isoform a [Homo sapiens] 46 1e-04 gi|53729344 plakophilin 1 isoform 1a [Homo sapiens] 46 1e-04 gi|169218113 PREDICTED: similar to plakophilin 1, partial [Homo ... 46 1e-04 gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens] 45 2e-04 gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens] 45 2e-04 gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens] 45 2e-04 gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] 45 2e-04 gi|189011568 adenomatous polyposis coli [Homo sapiens] 44 4e-04 gi|189011566 adenomatous polyposis coli [Homo sapiens] 44 4e-04 gi|53759122 adenomatous polyposis coli [Homo sapiens] 44 4e-04 gi|224589129 karyopherin 7 [Homo sapiens] 44 5e-04 gi|6005830 plakophilin 3 [Homo sapiens] 42 0.002 gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [... 41 0.005 gi|54607053 GCN1 general control of amino-acid synthesis 1-like ... 39 0.013 gi|6912478 karyopherin alpha 6 [Homo sapiens] 38 0.030 gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [... 38 0.039 gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [... 38 0.039 >gi|4504811 junction plakoglobin [Homo sapiens] Length = 745 Score = 1469 bits (3804), Expect = 0.0 Identities = 745/745 (100%), Positives = 745/745 (100%) Query: 1 MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60 MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT Sbjct: 1 MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60 Query: 61 YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120 YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS Sbjct: 61 YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120 Query: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM Sbjct: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180 Query: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE Sbjct: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240 Query: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ Sbjct: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300 Query: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH Sbjct: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360 Query: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC Sbjct: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420 Query: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY Sbjct: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480 Query: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR Sbjct: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540 Query: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI Sbjct: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600 Query: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY Sbjct: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660 Query: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM Sbjct: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720 Query: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745 DGDYPIDTYSDGLRPPYPTADHMLA Sbjct: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745 >gi|12056468 junction plakoglobin [Homo sapiens] Length = 745 Score = 1469 bits (3804), Expect = 0.0 Identities = 745/745 (100%), Positives = 745/745 (100%) Query: 1 MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60 MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT Sbjct: 1 MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60 Query: 61 YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120 YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS Sbjct: 61 YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120 Query: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM Sbjct: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180 Query: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE Sbjct: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240 Query: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ Sbjct: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300 Query: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH Sbjct: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360 Query: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC Sbjct: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420 Query: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY Sbjct: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480 Query: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR Sbjct: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540 Query: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI Sbjct: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600 Query: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY Sbjct: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660 Query: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM Sbjct: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720 Query: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745 DGDYPIDTYSDGLRPPYPTADHMLA Sbjct: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745 >gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa [Homo sapiens] Length = 781 Score = 952 bits (2462), Expect = 0.0 Identities = 511/749 (68%), Positives = 585/749 (78%), Gaps = 19/749 (2%) Query: 1 MEVMNLMEQPIK--VTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKT 58 ME+ ME K V+ WQQ DSGIHSGA T PS+S KG EE++ Q + Sbjct: 8 MELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWE 67 Query: 59 TTYTQGVPPSQ-GDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLA 117 ++Q Q D++ Q + T RA+RVR AM P E + TN+QRLA Sbjct: 68 QGFSQSFTQEQVADIDGQYAMT-RAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLA 126 Query: 118 EPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRR 177 EPSQ+LK A+V+LINYQDDAELATRA+PELTKLLNDED VVV KAA++V+QLSKKEASR Sbjct: 127 EPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRH 186 Query: 178 ALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSS 237 A+M SPQ+V+A+VRTMQNT+D++TARCT LHNLSHHREGLLAIFKSGGIPALV+ML S Sbjct: 187 AIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS 246 Query: 238 PVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAY 297 PV+SVLFYAITTLHNLLL+QEGAKMAVRLA GLQKMV LLNK N KFLAITTDCLQ+LAY Sbjct: 247 PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY 306 Query: 298 GNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357 GNQESKLIILA+GGPQALV IMR Y+YEKLLWTTSRVLKVLSVC SNKPAIVEAGGMQAL Sbjct: 307 GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366 Query: 358 GKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417 G HLT S RLVQNCLWTLRNLSD ATKQEG+E +L LV L DD+NV+TCA G LSN Sbjct: 367 GLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSN 426 Query: 418 LTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVR 477 LTCNN KNK +V Q G+EAL+ +LRAGD++DITEPA+CALRHLTSRH EAEMAQN+VR Sbjct: 427 LTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVR 486 Query: 478 LNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQD 537 L+YG+P +VKLL+ P+ WPL+KAT+GLIRNLALCPANHAPL+E IPRLVQLLV+AHQD Sbjct: 487 LHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD 546 Query: 538 AQRHVA-AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSS 596 QR + GTQQ + +GVRMEEIVEGCTGALHILARD NR+ I LNTIPLFVQLLYS Sbjct: 547 TQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP 606 Query: 597 VENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656 +ENIQRVAAGVLCELAQDKEAA+AI+AEGA+APL ELLHSRNEG ATYAAAVLFR+SEDK Sbjct: 607 IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDK 666 Query: 657 NPDYRKRVSVELTNSLFKHDPAAW-EAAQSMIPI---NEPYG-DDMDATYRPMYSSDVPL 711 DY+KR+SVELT+SLF+ +P AW E A + I EP G D +YR +S Sbjct: 667 PQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQ 726 Query: 712 DPLEMHMDMD---------GDYPIDTYSD 731 D L M M+ DYP+D D Sbjct: 727 DALGMDPMMEHEMGGHHPGADYPVDGLPD 755 >gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa [Homo sapiens] Length = 781 Score = 952 bits (2462), Expect = 0.0 Identities = 511/749 (68%), Positives = 585/749 (78%), Gaps = 19/749 (2%) Query: 1 MEVMNLMEQPIK--VTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKT 58 ME+ ME K V+ WQQ DSGIHSGA T PS+S KG EE++ Q + Sbjct: 8 MELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWE 67 Query: 59 TTYTQGVPPSQ-GDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLA 117 ++Q Q D++ Q + T RA+RVR AM P E + TN+QRLA Sbjct: 68 QGFSQSFTQEQVADIDGQYAMT-RAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLA 126 Query: 118 EPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRR 177 EPSQ+LK A+V+LINYQDDAELATRA+PELTKLLNDED VVV KAA++V+QLSKKEASR Sbjct: 127 EPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRH 186 Query: 178 ALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSS 237 A+M SPQ+V+A+VRTMQNT+D++TARCT LHNLSHHREGLLAIFKSGGIPALV+ML S Sbjct: 187 AIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS 246 Query: 238 PVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAY 297 PV+SVLFYAITTLHNLLL+QEGAKMAVRLA GLQKMV LLNK N KFLAITTDCLQ+LAY Sbjct: 247 PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY 306 Query: 298 GNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357 GNQESKLIILA+GGPQALV IMR Y+YEKLLWTTSRVLKVLSVC SNKPAIVEAGGMQAL Sbjct: 307 GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366 Query: 358 GKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417 G HLT S RLVQNCLWTLRNLSD ATKQEG+E +L LV L DD+NV+TCA G LSN Sbjct: 367 GLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSN 426 Query: 418 LTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVR 477 LTCNN KNK +V Q G+EAL+ +LRAGD++DITEPA+CALRHLTSRH EAEMAQN+VR Sbjct: 427 LTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVR 486 Query: 478 LNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQD 537 L+YG+P +VKLL+ P+ WPL+KAT+GLIRNLALCPANHAPL+E IPRLVQLLV+AHQD Sbjct: 487 LHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD 546 Query: 538 AQRHVA-AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSS 596 QR + GTQQ + +GVRMEEIVEGCTGALHILARD NR+ I LNTIPLFVQLLYS Sbjct: 547 TQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP 606 Query: 597 VENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656 +ENIQRVAAGVLCELAQDKEAA+AI+AEGA+APL ELLHSRNEG ATYAAAVLFR+SEDK Sbjct: 607 IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDK 666 Query: 657 NPDYRKRVSVELTNSLFKHDPAAW-EAAQSMIPI---NEPYG-DDMDATYRPMYSSDVPL 711 DY+KR+SVELT+SLF+ +P AW E A + I EP G D +YR +S Sbjct: 667 PQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQ 726 Query: 712 DPLEMHMDMD---------GDYPIDTYSD 731 D L M M+ DYP+D D Sbjct: 727 DALGMDPMMEHEMGGHHPGADYPVDGLPD 755 >gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa [Homo sapiens] Length = 781 Score = 952 bits (2462), Expect = 0.0 Identities = 511/749 (68%), Positives = 585/749 (78%), Gaps = 19/749 (2%) Query: 1 MEVMNLMEQPIK--VTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKT 58 ME+ ME K V+ WQQ DSGIHSGA T PS+S KG EE++ Q + Sbjct: 8 MELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWE 67 Query: 59 TTYTQGVPPSQ-GDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLA 117 ++Q Q D++ Q + T RA+RVR AM P E + TN+QRLA Sbjct: 68 QGFSQSFTQEQVADIDGQYAMT-RAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLA 126 Query: 118 EPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRR 177 EPSQ+LK A+V+LINYQDDAELATRA+PELTKLLNDED VVV KAA++V+QLSKKEASR Sbjct: 127 EPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRH 186 Query: 178 ALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSS 237 A+M SPQ+V+A+VRTMQNT+D++TARCT LHNLSHHREGLLAIFKSGGIPALV+ML S Sbjct: 187 AIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS 246 Query: 238 PVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAY 297 PV+SVLFYAITTLHNLLL+QEGAKMAVRLA GLQKMV LLNK N KFLAITTDCLQ+LAY Sbjct: 247 PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY 306 Query: 298 GNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357 GNQESKLIILA+GGPQALV IMR Y+YEKLLWTTSRVLKVLSVC SNKPAIVEAGGMQAL Sbjct: 307 GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366 Query: 358 GKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417 G HLT S RLVQNCLWTLRNLSD ATKQEG+E +L LV L DD+NV+TCA G LSN Sbjct: 367 GLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSN 426 Query: 418 LTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVR 477 LTCNN KNK +V Q G+EAL+ +LRAGD++DITEPA+CALRHLTSRH EAEMAQN+VR Sbjct: 427 LTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVR 486 Query: 478 LNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQD 537 L+YG+P +VKLL+ P+ WPL+KAT+GLIRNLALCPANHAPL+E IPRLVQLLV+AHQD Sbjct: 487 LHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD 546 Query: 538 AQRHVA-AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSS 596 QR + GTQQ + +GVRMEEIVEGCTGALHILARD NR+ I LNTIPLFVQLLYS Sbjct: 547 TQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP 606 Query: 597 VENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656 +ENIQRVAAGVLCELAQDKEAA+AI+AEGA+APL ELLHSRNEG ATYAAAVLFR+SEDK Sbjct: 607 IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDK 666 Query: 657 NPDYRKRVSVELTNSLFKHDPAAW-EAAQSMIPI---NEPYG-DDMDATYRPMYSSDVPL 711 DY+KR+SVELT+SLF+ +P AW E A + I EP G D +YR +S Sbjct: 667 PQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQ 726 Query: 712 DPLEMHMDMD---------GDYPIDTYSD 731 D L M M+ DYP+D D Sbjct: 727 DALGMDPMMEHEMGGHHPGADYPVDGLPD 755 >gi|31657114 armadillo repeat containing 4 [Homo sapiens] Length = 1044 Score = 76.6 bits (187), Expect = 8e-14 Identities = 111/528 (21%), Positives = 208/528 (39%), Gaps = 52/528 (9%) Query: 144 LPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM---GSPQLVAAVVRTMQNTS--- 197 LP + +L+ + AA + ++K + +RR + G +LVA + +T Sbjct: 537 LPIMVNILDSPHKSLKCLAAETIANVAKFKRARRVVRQHGGITKLVALLDCAHDSTKPAQ 596 Query: 198 -------DLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTL 250 D++ ARC L + S AI K+GGIP L R+L + E++L + TL Sbjct: 597 SSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTL 656 Query: 251 HNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANG 310 +E + A++ ++ +V LN N + + A ++E++ ++ +G Sbjct: 657 QE-CASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCA-EDKETRDLVRLHG 714 Query: 311 GPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQ 370 G + L ++ N ++ L + + S+ N E ++ L LT ++ Sbjct: 715 GLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLV 774 Query: 371 NCLWTL------RNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSK 424 N + L R + K G++ ++ +LV VNV T A G C Sbjct: 775 NVVGALGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNV-TKAVG-----ACAVEP 828 Query: 425 NKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPA 484 ++ L+ ++L+ D A + + EM ++ V G+ Sbjct: 829 ESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVG---GLEL 885 Query: 485 IVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAA 544 IV LL N+ ++ + I N+A N A + + V+P L +L + + H+A Sbjct: 886 IVNLLKSDNK-EVLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLA- 943 Query: 545 GTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVA 604 E I C NR+ + V+ L S+ N+ R Sbjct: 944 ------------EAISRCCMWG--------RNRVAFGEHKAVAPLVRYLKSNDTNVHRAT 983 Query: 605 AGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRI 652 A L +L++D + + GA L++++ S ++ AA + I Sbjct: 984 AQALYQLSEDADNCITMHENGAVKLLLDMVGSPDQDLQEAAAGCISNI 1031 Score = 65.5 bits (158), Expect = 2e-10 Identities = 113/507 (22%), Positives = 198/507 (39%), Gaps = 60/507 (11%) Query: 195 NTSDLDTARC---TTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLH 251 N + D +C + IL +SH+ + I GG+P +V +L SP +S+ A T+ Sbjct: 501 NLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIA 560 Query: 252 NLLLYQEGAKMAVRLADGLQKMVPLL----NKNNPKFLAI-------TTDCLQLLAYGNQ 300 N+ ++ A+ VR G+ K+V LL + P ++ C L + Sbjct: 561 NVAKFKR-ARRVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCS 619 Query: 301 ES---KLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357 +S K I GG L ++++ S+E +L L+ + + + AI ++ L Sbjct: 620 KSHTNKEAIRKAGGIPLLARLLKT-SHENMLIPVVGTLQECASEENYRAAIKAERIIENL 678 Query: 358 GKHLTSNSPRLVQNCLWTL------RNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCA 411 K+L S + +L ++C + + D+ GL+ + +L N D+ L Sbjct: 679 VKNLNSENEQLQEHCAMAIYQCAEDKETRDLVRLHGGLKPLASLLNN---TDNKERLAAV 735 Query: 412 TGTLSNLTCNNSK-NKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAE 470 TG + C+ SK N T + +E L+ L +++ V AL Sbjct: 736 TGAI--WKCSISKENVTKFREYKAIETLVG--LLTDQPEEVLVNVVGALGECCQERENRV 791 Query: 471 MAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQL 530 + VR GI +V LL NQ LV T + A+ P + + + L L Sbjct: 792 I----VRKCGGIQPLVNLLVGINQALLVNVT-KAVGACAVEPESMMIIDRLDGVRLLWSL 846 Query: 531 LVKAHQDAQRHVA------------AGTQ-QPYTDGVRM---------EEIVEGCTGALH 568 L H D + A AG + + G+ + +E++ A+ Sbjct: 847 LKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAIT 906 Query: 569 ILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASA 628 +A+D N I +PL +L ++ ++ A + A A A Sbjct: 907 NIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVA 966 Query: 629 PLMELLHSRNEGTATYAAAVLFRISED 655 PL+ L S + A L+++SED Sbjct: 967 PLVRYLKSNDTNVHRATAQALYQLSED 993 Score = 57.8 bits (138), Expect = 4e-08 Identities = 95/470 (20%), Positives = 193/470 (41%), Gaps = 52/470 (11%) Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287 I LV+ L ++ A+ ++ + L QE ++A+R GL+ ++ LL + K Sbjct: 454 IQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEVKCKIG 513 Query: 288 TTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPA 347 + L+ +++ N + + I+ GG +V I+ + ++ L + + ++ + Sbjct: 514 SLKILKEISH-NPQIRQNIVDLGGLPIMVNIL-DSPHKSLKCLAAETIANVAKFKRARRV 571 Query: 348 IVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNL-------------SDVATKQEGLESV 392 + + GG+ L L +S + Q+ L+ R++ S T +E + Sbjct: 572 VRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNKEAIRKA 631 Query: 393 --LKILVNQLSVDDVNVLTCATGTLSNLTCNNSKN-KTLVTQNSGVEALIHAILRAGDKD 449 + +L L N+L GTL C + +N + + +E L+ + + + Sbjct: 632 GGIPLLARLLKTSHENMLIPVVGTLQE--CASEENYRAAIKAERIIENLVKNL--NSENE 687 Query: 450 DITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLA 509 + E A+ E + ++ VRL+ G+ + LLN + + A G I + Sbjct: 688 QLQEHCAMAIYQCA----EDKETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCS 743 Query: 510 LCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA------------------AGTQQPYT 551 + N +E I LV LL ++ +V G QP Sbjct: 744 ISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQERENRVIVRKCGGIQPLV 803 Query: 552 D---GVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVL 608 + G+ + ++ T A+ A +P + M I RL+ + L LL + +++ AA L Sbjct: 804 NLLVGIN-QALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWAL 862 Query: 609 CELAQD-KEAADAIDA-EGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656 C ++ K+A + + + G ++ LL S N+ A + I++D+ Sbjct: 863 CPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQ 912 >gi|189409124 armadillo repeat containing 3 [Homo sapiens] Length = 872 Score = 75.9 bits (185), Expect = 1e-13 Identities = 105/480 (21%), Positives = 205/480 (42%), Gaps = 48/480 (10%) Query: 143 ALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTA 202 A+ LTKLL ED +V A MI L+ ++ L+ ++ +V+ + ++ Sbjct: 68 AVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKK-LLRELDVMNSVIAQLAPEEEVVIH 126 Query: 203 RCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLL-YQEGAK 261 + L N+S + IF+ GG+ L+R+LSSP V ++ ++NL+ +Q AK Sbjct: 127 EFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAK 186 Query: 262 MAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRN 321 + + + + ++ LL P + L ++A ++ES+ ++ N G L++I+ Sbjct: 187 L--QELNAIPPILDLLKSEYPVIQLLALKTLGVIA-NDKESRTMLRDNQGLDHLIKILET 243 Query: 322 YSYEKLLWTTSRVLKVLSVCPSNKPAIV---EAGGMQALGKHL-TSNSPRLVQNCLWTLR 377 L L V++ C + +V + GG++ L S P + +N + Sbjct: 244 KELNDL---HIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKN---AAK 297 Query: 378 NLSDVATKQEGL-----ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQN 432 ++ A E + V K LV L ++ A+ +S + C NS +K N Sbjct: 298 AITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAM-CENSGSKDFF-NN 355 Query: 433 SGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQP 492 G+ LI L D +++ E A AL +LT+ +P N+ GI ++ LL+ Sbjct: 356 QGIPQLIQ--LLKSDNEEVREAAALALANLTTCNP---ANANAAAEADGIDPLINLLSSK 410 Query: 493 NQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA--------- 543 + A ++ N+A+ +Q ++ ++ L A+ Q A Sbjct: 411 RDGAIANAAT-VLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACD 469 Query: 544 ---------AGTQQPYTDGVRM--EEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQL 592 +G +P + +R +E+ + + A+ + A D + E+ RL + + ++ Sbjct: 470 VEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEV 529 Score = 42.0 bits (97), Expect = 0.002 Identities = 81/373 (21%), Positives = 150/373 (40%), Gaps = 42/373 (11%) Query: 314 ALVQIMRNYSYEKLLWTTSRVL-KVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNC 372 A V +M N E++L + K NK ++E G ++ L K LT + +N Sbjct: 28 ATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNA 87 Query: 373 LWT---LRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLV 429 L + +DV L+ + ++ ++V + A+ L+N++ + +K + Sbjct: 88 TMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYT-SKVQI 146 Query: 430 TQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLL 489 ++ G+E LI +L + D D C + A++ + LN IP I+ LL Sbjct: 147 FEHGGLEPLIR-LLSSPDPDVKKNSMECIYNLVQDFQCRAKLQE----LN-AIPPILDLL 200 Query: 490 NQPNQWPLVKA----TIGLIRNLALCPANHAPLQEAAVIPRLVQLL-VKAHQDAQRHVAA 544 +++P+++ T+G+I N + L++ + L+++L K D A Sbjct: 201 K--SEYPVIQLLALKTLGVIAN---DKESRTMLRDNQGLDHLIKILETKELNDLHIEALA 255 Query: 545 GTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVA 604 D M +I + TG L L N S++ +IQ+ A Sbjct: 256 VIANCLEDMDTMVQIQQ--TGGLKKLLSFAEN------------------STIPDIQKNA 295 Query: 605 AGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK-NPDYRKR 663 A + + A D E + L+ LL S N+GT A+ + + E+ + D+ Sbjct: 296 AKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNN 355 Query: 664 VSVELTNSLFKHD 676 + L K D Sbjct: 356 QGIPQLIQLLKSD 368 >gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] Length = 1363 Score = 57.0 bits (136), Expect = 6e-08 Identities = 76/336 (22%), Positives = 148/336 (44%), Gaps = 23/336 (6%) Query: 203 RCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKM 262 +CT +L S + + +F G A R +++ ++ T H +L + K+ Sbjct: 568 QCTPLLLAATSGALDTIQYLFSIG---ANWRKTDIKGNNIIHLSVLTFHTEVL-KYIIKL 623 Query: 263 AVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY 322 + + +V +L + K + L+++ N + IL G AL+ ++++ Sbjct: 624 NIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKS- 682 Query: 323 SYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-- 380 S KL T +L +S S A+VEAGG+ +L L + P + C L +++ Sbjct: 683 SKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC 742 Query: 381 ---DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEA 437 DV K G+ S L+N L+++ NVL + L N N+ V ++ G+ Sbjct: 743 ENKDVIAKYNGIPS----LINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY 798 Query: 438 LIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPL 497 LI + + D D + + A+ + + E Q+++ + IP +V L Sbjct: 799 LIRFL--SSDSDVLKAVSSAAIAEVGRDNKE---IQDAIAMEGAIPPLVALFKGKQISVQ 853 Query: 498 VKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVK 533 +K + + +LA +++A +Q+A + L + L+K Sbjct: 854 MKGAMA-VESLA---SHNALIQKAFLEKSLTKYLLK 885 Score = 54.3 bits (129), Expect = 4e-07 Identities = 61/291 (20%), Positives = 125/291 (42%), Gaps = 16/291 (5%) Query: 205 TTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAV 264 T +L N+S H+ + A+ ++GGIP+L+ +L V L+++ + K + Sbjct: 691 TVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCEN--KDVI 748 Query: 265 RLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSY 324 +G+ ++ LLN N L +C+++L GN+ ++ + + G L++ + + S Sbjct: 749 AKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSD 808 Query: 325 EKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL-----GKHLTSNSPRLVQNCLWTLRNL 379 +++ + +V + AI G + L GK ++ + + +L + Sbjct: 809 VLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM--AVESLASH 866 Query: 380 SDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI 439 + + K +S+ K L+ L ++V L L K + + + G +I Sbjct: 867 NALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIGYSFII 926 Query: 440 HAILRAGDK-DDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLL 489 + +L K + AV AL ++ M QN + GI +V+LL Sbjct: 927 NMLLSPSAKMQYVGGEAVIAL------SKDSRMHQNQICEGNGIAPLVRLL 971 Score = 45.8 bits (107), Expect = 1e-04 Identities = 42/180 (23%), Positives = 83/180 (46%), Gaps = 9/180 (5%) Query: 144 LPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM---GSPQLVAAVVRTMQNTSDLD 200 +P L LL + K +++ +S +++ AL+ G P L+ +V Sbjct: 673 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVH--- 729 Query: 201 TARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGA 260 +RC IL++++ E I K GIP+L+ +L+ +E+VL + + L + E Sbjct: 730 -SRCAV-ILYDIAQC-ENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENN 786 Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320 + AVR GL ++ L+ ++ A+++ + + N+E + I G LV + + Sbjct: 787 QRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFK 846 Score = 42.0 bits (97), Expect = 0.002 Identities = 43/177 (24%), Positives = 74/177 (41%), Gaps = 22/177 (12%) Query: 482 IPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRH 541 IPA++ LL ++ L T+GL+ N++ + L EA IP L+ LLV + Sbjct: 673 IPALINLLKS-SKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSR 731 Query: 542 VAAG----TQQPYTD---------------GVRMEEIVEGCTGALHILARDPMNRMEIFR 582 A Q D + +E ++ + +L N R Sbjct: 732 CAVILYDIAQCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVR 791 Query: 583 LNT-IPLFVQLLYSSVENIQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR 637 + +P ++ L S + ++ V++ + E+ +D KE DAI EGA PL+ L + Sbjct: 792 EHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGK 848 Score = 35.8 bits (81), Expect = 0.15 Identities = 23/80 (28%), Positives = 36/80 (45%) Query: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNE 639 I TIP + LL SS +Q G+L ++ K A A+ G L+ LL Sbjct: 667 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEP 726 Query: 640 GTATYAAAVLFRISEDKNPD 659 + A +L+ I++ +N D Sbjct: 727 EVHSRCAVILYDIAQCENKD 746 >gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens] Length = 659 Score = 52.8 bits (125), Expect = 1e-06 Identities = 45/207 (21%), Positives = 92/207 (44%), Gaps = 5/207 (2%) Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320 K + + + ++V L++++ K CL L+ Q+ + + + L+++++ Sbjct: 363 KKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQ 422 Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380 N E L+ +S + +L +K I+E+G ++ L S +P L N +W L N++ Sbjct: 423 NAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMA 482 Query: 381 DVATKQEGLESVLKILVNQ----LSVDDVNVLTCATGTLSNLTCNNSK-NKTLVTQNSGV 435 A ++ + + + Q LS D+NVL G L NL +K + T + Sbjct: 483 FQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQI 542 Query: 436 EALIHAILRAGDKDDITEPAVCALRHL 462 + IL ++ E +C L ++ Sbjct: 543 MQAVTLILEGEHNIEVKEQTLCILANI 569 Score = 43.1 bits (100), Expect = 0.001 Identities = 78/376 (20%), Positives = 160/376 (42%), Gaps = 36/376 (9%) Query: 101 LLATQVEGQATNLQRLAEPS---QLLKSAIVHLINYQDDA---ELATRALPELTKLLNDE 154 LL +VEG T L L EP Q + S HLI D + A+ ++ +L +D Sbjct: 279 LLEERVEGAET-LAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDL 337 Query: 155 DPVVVTKAA---MIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTS---DLDTARCTTSI 208 + A + + + E R+ ++ + ++ +V + +S L RC Sbjct: 338 KHAHELRQAAFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRC---- 393 Query: 209 LHNLSHHREGLLAIFKSGGI-PALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267 LH+LS + L F+ + L+++L + + +L A + L NLLL +K + + Sbjct: 394 LHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILES 453 Query: 268 DGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQALVQIMRNYSYEK 326 ++ + L NP L +A+ Q+ K IL + + L +++ + Sbjct: 454 GAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNV 513 Query: 327 LLWTTSRVLKVLSVCP-------SNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNL 379 L+ T + +LS P ++ I++A + G+H + + + L L N+ Sbjct: 514 LMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEH----NIEVKEQTLCILANI 569 Query: 380 SDVATKQEGL---ESVLKILVNQLSVDDVNVLTCATGTLSNLTCN---NSKNKTLVTQNS 433 +D T ++ + + +L+ + + V + A +SNL N S+ + ++ Sbjct: 570 ADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDM 629 Query: 434 GVEALIHAILRAGDKD 449 G+ ++H + ++ D + Sbjct: 630 GIVDILHKLSQSPDSN 645 >gi|11034811 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) [Homo sapiens] Length = 1225 Score = 52.0 bits (123), Expect = 2e-06 Identities = 61/245 (24%), Positives = 103/245 (42%), Gaps = 29/245 (11%) Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287 +P +++ML SV A L +L K +R G+Q +V LL+ + Sbjct: 552 LPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRS 611 Query: 288 TTDCLQLLAYG--NQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK 345 L+ L YG N ++K+ + GG ALV+++R + ++ + VL LS C + K Sbjct: 612 ACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALK 671 Query: 346 PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDV 405 I +Q+ L L N V G E+ ++ + Sbjct: 672 MPI--------------------IQDALAVLTNA--VIIPHSGWENSPLQDDRKIQLHSS 709 Query: 406 NVLTCATGTLSNLTCNNSKNKTLVTQNSGV-EALIHAILRAGDKDDI----TEPAVCALR 460 VL ATG L N++ + + + + G+ +AL++ I A +I E VC LR Sbjct: 710 QVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILR 769 Query: 461 HLTSR 465 +L+ R Sbjct: 770 NLSYR 774 Score = 37.0 bits (84), Expect = 0.067 Identities = 93/412 (22%), Positives = 158/412 (38%), Gaps = 87/412 (21%) Query: 144 LPELTKLLNDEDPVVVTKAAMIVNQL----SKKEASRRALMGSPQLVAAVVRTMQNTSDL 199 LPE+ ++L + P V + AA + L +K +A R G LV + M Sbjct: 552 LPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMT----- 606 Query: 200 DTARCTTSILHNLSHHR---EGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLY 256 + R L NL + + + +A+ GGIPALVR+L + + +T Sbjct: 607 EVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVT-------- 658 Query: 257 QEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALV 316 G + D L+ +P++ LA+ T+ + + G + S L + Sbjct: 659 --GVLWNLSSCDALK--MPIIQ----DALAVLTNAVIIPHSGWENSPL------QDDRKI 704 Query: 317 QIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGM---------QALGKHLTSNSPR 367 Q+ +S + L T + V S + + E G+ ALG + + Sbjct: 705 QL---HSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGS--SEIDSK 759 Query: 368 LVQNCLWTLRNLSD--VATKQEGLESVLKILVNQLSVDDVNVLTCATGT---LSNLTCNN 422 V+NC+ LRNLS A +G + D+++ L C + C Sbjct: 760 TVENCVCILRNLSYRLAAETSQG---------QHMGTDELDGLLCGEANGKDAESSGCWG 810 Query: 423 SKNKTLVTQN---------------SGVEALIH--------AILRAGDKDDITEPAVCAL 459 K K +Q+ G++ L H +L D E A AL Sbjct: 811 KKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGAL 870 Query: 460 RHLTSRHPE-AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLAL 510 ++L + + + + +VR G+P +V+LL N +V A +RN+AL Sbjct: 871 QNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDND-RVVCAVATALRNMAL 921 Score = 35.4 bits (80), Expect = 0.19 Identities = 33/137 (24%), Positives = 64/137 (46%), Gaps = 11/137 (8%) Query: 389 LESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDK 448 L V+++L +Q +V + A L +L ++K K + + G++ L+ + Sbjct: 552 LPEVIQMLQHQFP----SVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHR--M 605 Query: 449 DDITEPAVCALRHLTSRHPEAEMAQNSVRLNY--GIPAIVKLLNQPNQWPLVKATIGLIR 506 ++ A ALR+L + N + L GIPA+V+LL + + + G++ Sbjct: 606 TEVHRSACGALRNLVYGKANDD---NKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLW 662 Query: 507 NLALCPANHAPLQEAAV 523 NL+ C A P+ + A+ Sbjct: 663 NLSSCDALKMPIIQDAL 679 >gi|4504897 karyopherin alpha 2 [Homo sapiens] Length = 529 Score = 51.2 bits (121), Expect = 3e-06 Identities = 94/481 (19%), Positives = 186/481 (38%), Gaps = 79/481 (16%) Query: 95 GEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAE--LATRALPELTKLLN 152 G+DS+ + ++E L++ + Q+LK V ++ DDA L + T + Sbjct: 21 GKDSTEMRRRRIEVNV-ELRKAKKDDQMLKRRNVS--SFPDDATSPLQENRNNQGTVNWS 77 Query: 153 DEDPVVVTKAAMIVNQLSKKEASRRALMGS--------------PQLVAAVVRTMQNTSD 198 +D V ++ + NQL +A+R+ L P+ V+ + RT + Sbjct: 78 VDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQ 137 Query: 199 LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNL----- 253 ++A T+I S + A+ G IPA + +L+SP + A+ L N+ Sbjct: 138 FESAWALTNIASGTSEQTK---AVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGS 194 Query: 254 ----LLYQEGA----------------------------------KMAVRLADGLQKMVP 275 L+ + GA K D +++++P Sbjct: 195 VFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILP 254 Query: 276 ----LLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTT 331 LL+ ++P+ LA T + L G E +++ G LV+++ + Sbjct: 255 TLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPAL 314 Query: 332 SRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLES 391 + +++ +++AG + LT+ + + WT+ N++ A +Q+ ++ Sbjct: 315 RAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT--AGRQDQIQQ 372 Query: 392 VLK-----ILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAG 446 V+ LV+ LS D A ++N T + + + + G+ + +L A Sbjct: 373 VVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAK 432 Query: 447 DKDDITE--PAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGL 504 D I A+ + + E E + G+ I L N N+ + KA++ L Sbjct: 433 DTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENE-SVYKASLSL 491 Query: 505 I 505 I Sbjct: 492 I 492 Score = 38.9 bits (89), Expect = 0.018 Identities = 44/176 (25%), Positives = 77/176 (43%), Gaps = 26/176 (14%) Query: 347 AIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-------DVATKQEGLESVLKILVNQ 399 A+V+ G + A L S + + +W L N++ D+ K ++ +L + Sbjct: 157 AVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLAL---- 212 Query: 400 LSVDDVNVLTCATGTLSNLT---CNNSKNKTLVTQNSGVEALIHAILRAGDKDD--ITEP 454 L+V D++ L C G L NLT N +NK VE ++ ++R DD + Sbjct: 213 LAVPDMSSLAC--GYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLAD 270 Query: 455 AVCALRHLTSRHPE--AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNL 508 A+ +LT E + + V +P +VKLL ++ P+V + I N+ Sbjct: 271 TCWAISYLTDGPNERIGMVVKTGV-----VPQLVKLLG-ASELPIVTPALRAIGNI 320 >gi|4502247 armadillo repeat protein [Homo sapiens] Length = 962 Score = 50.8 bits (120), Expect = 4e-06 Identities = 60/242 (24%), Positives = 103/242 (42%), Gaps = 28/242 (11%) Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287 +P ++ ML PV+ V A L +L EG K VR GL +V LL+ + Sbjct: 360 LPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRR 419 Query: 288 TTDCLQLLAYG-NQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKP 346 L+ L+YG + ++K I GG ALV+++R ++ + L LS K Sbjct: 420 ACGALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKM 479 Query: 347 AIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVN 406 I++ G+Q L + +V + W D + +V K Sbjct: 480 VIID-HGLQTLTHEV------IVPHSGWEREPNEDSKPRDAEWTTVFK------------ 520 Query: 407 VLTCATGTLSNLTCNNSKNKTLVTQNSG-VEALIHAILRAGDKDDI----TEPAVCALRH 461 +G L N++ + ++ + + + G V+AL+HA+ A + D E VC +R+ Sbjct: 521 ---NTSGCLRNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRN 577 Query: 462 LT 463 L+ Sbjct: 578 LS 579 Score = 42.7 bits (99), Expect = 0.001 Identities = 54/179 (30%), Positives = 79/179 (44%), Gaps = 21/179 (11%) Query: 102 LATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDE-DPVVVT 160 LA G +L RL S + SA + + LPE+ +L DPV Sbjct: 325 LAQPERGSMGSLDRLVRRSPSVDSA-------RKEPRWRDPELPEVLAMLRHPVDPVKAN 377 Query: 161 KAAMIVNQLSKKEASRRA---LMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHRE 217 AA + + + E +R L G P LVA + + + R L NLS+ R+ Sbjct: 378 AAAYLQHLCFENEGVKRRVRQLRGLPLLVALL-----DHPRAEVRRRACGALRNLSYGRD 432 Query: 218 --GLLAIFKSGGIPALVRMLSSPVESVLFYAIT-TLHNLLLYQEGAKMAVRLADGLQKM 273 AI GG+PALVR+L + ++ + +T TL NL Y E KM + + GLQ + Sbjct: 433 TDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSY-EPLKMVI-IDHGLQTL 489 >gi|53829376 plakophilin 4 isoform b [Homo sapiens] Length = 1149 Score = 45.8 bits (107), Expect = 1e-04 Identities = 82/353 (23%), Positives = 137/353 (38%), Gaps = 53/353 (15%) Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287 +P ++ ML SV A L +L KM V G++ +V LL+ + Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589 Query: 288 TTDCLQLLAYGNQ--ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK 345 L+ L +G E+K+ + GG AL++++R ++ + VL LS C + K Sbjct: 590 ACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVK 649 Query: 346 PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDV 405 I+ AL T + +V + W + D +++ Sbjct: 650 MTIIR----DALS---TLTNTVIVPHSGWNNSSFDD---------------DHKIKFQTS 687 Query: 406 NVLTCATGTLSNLTCNNSKNKTLVTQNSG-VEAL---IHAILRAGDKDDIT-EPAVCALR 460 VL TG L NL+ + + + G V++L IH + D D T E VC LR Sbjct: 688 LVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLR 747 Query: 461 HLTSRHPEAEMAQNSVRLNYGIPAIVKLL--------NQPNQWPLVKAT----------- 501 +L+ R E+ RL G+ + LL ++P+ W K Sbjct: 748 NLSYR---LELEVPQARL-LGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWD 803 Query: 502 -IGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDG 553 +G I L+ P L +V+ + LL ++ A +AG+ Q + G Sbjct: 804 GVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAG 856 Score = 37.7 bits (86), Expect = 0.039 Identities = 103/438 (23%), Positives = 164/438 (37%), Gaps = 115/438 (26%) Query: 134 QDDAELATR--ALPELTKLLNDEDPVVVTKAAMIVNQLS------KKEASRRALMGSPQL 185 +D E A R LPE+ +L + P V AA + L K E R L G L Sbjct: 518 KDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCR--LGGIKHL 575 Query: 186 VAAVVRTMQNTSDLDTARCTTSILHNLSHHR---EGLLAIFKSGGIPALVRMLSSPVESV 242 V + + L+ + L NL + E +A+ GGIPAL+R+L +++ Sbjct: 576 VDLLDHRV-----LEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAE 630 Query: 243 LFYAITTLHNLLLYQEGAKMAVRLADGLQKM-----VPLLNKNNPKF------------- 284 + +T + L + KM + + D L + VP NN F Sbjct: 631 VRELVTGVLWNLSSCDAVKMTI-IRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLV 689 Query: 285 LAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSN 344 L TT CL+ L+ +E++ + MR S E L+ +L V+ C + Sbjct: 690 LRNTTGCLRNLSSAGEEAR-------------KQMR--SCEGLV---DSLLYVIHTCVNT 731 Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDD 404 + + V+NC+ TLRNLS L++ V Q + Sbjct: 732 -----------------SDYDSKTVENCVCTLRNLS----------YRLELEVPQARLLG 764 Query: 405 VNVLTCATGTL-----SNLTCNNSKNKT------------------LVTQNSGVEALIH- 440 +N L G S +C K K L GVE L H Sbjct: 765 LNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHP 824 Query: 441 -------AILRAGDKDDITEPAVCALRHLTSRHPE-AEMAQNSVRLNYGIPAIVKLLNQP 492 +L E + +L++L++ + + A + +VR G+P +V+LL Sbjct: 825 SVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMD 884 Query: 493 NQWPLVKATIGLIRNLAL 510 N +V + +RN+AL Sbjct: 885 ND-RVVSSVATALRNMAL 901 Score = 34.7 bits (78), Expect = 0.33 Identities = 28/117 (23%), Positives = 56/117 (47%), Gaps = 13/117 (11%) Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-DVATKQEGLESVLKILVNQL--- 400 + A+ + G+ L + L ++ R+V + LRN++ DV K+ + ++ LVN+L Sbjct: 865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGG 924 Query: 401 ------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDI 451 S + + + CA L +T N +N + + G+E L++ GD+ + Sbjct: 925 NGPSVLSDETMAAICCA---LHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSL 978 Score = 30.8 bits (68), Expect = 4.8 Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 19/139 (13%) Query: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI- 439 + A + L V+ +L +Q N A L +L ++K K V + G++ L+ Sbjct: 522 EFAWRDPELPEVIHMLQHQFPSVQAN----AAAYLQHLCFGDNKVKMEVCRLGGIKHLVD 577 Query: 440 ---HAILRAGDKDDITEPAVCALRHLT--SRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQ 494 H +L ++ + A ALR+L E ++A +V GIPA+++LL + Sbjct: 578 LLDHRVL------EVQKNACGALRNLVFGKSTDENKIAMKNVG---GIPALLRLLRKSID 628 Query: 495 WPLVKATIGLIRNLALCPA 513 + + G++ NL+ C A Sbjct: 629 AEVRELVTGVLWNLSSCDA 647 >gi|53829374 plakophilin 4 isoform a [Homo sapiens] Length = 1192 Score = 45.8 bits (107), Expect = 1e-04 Identities = 82/353 (23%), Positives = 137/353 (38%), Gaps = 53/353 (15%) Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287 +P ++ ML SV A L +L KM V G++ +V LL+ + Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589 Query: 288 TTDCLQLLAYGNQ--ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK 345 L+ L +G E+K+ + GG AL++++R ++ + VL LS C + K Sbjct: 590 ACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVK 649 Query: 346 PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDV 405 I+ AL T + +V + W + D +++ Sbjct: 650 MTIIR----DALS---TLTNTVIVPHSGWNNSSFDD---------------DHKIKFQTS 687 Query: 406 NVLTCATGTLSNLTCNNSKNKTLVTQNSG-VEAL---IHAILRAGDKDDIT-EPAVCALR 460 VL TG L NL+ + + + G V++L IH + D D T E VC LR Sbjct: 688 LVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLR 747 Query: 461 HLTSRHPEAEMAQNSVRLNYGIPAIVKLL--------NQPNQWPLVKAT----------- 501 +L+ R E+ RL G+ + LL ++P+ W K Sbjct: 748 NLSYR---LELEVPQARL-LGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWD 803 Query: 502 -IGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDG 553 +G I L+ P L +V+ + LL ++ A +AG+ Q + G Sbjct: 804 GVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAG 856 Score = 37.7 bits (86), Expect = 0.039 Identities = 103/438 (23%), Positives = 164/438 (37%), Gaps = 115/438 (26%) Query: 134 QDDAELATR--ALPELTKLLNDEDPVVVTKAAMIVNQLS------KKEASRRALMGSPQL 185 +D E A R LPE+ +L + P V AA + L K E R L G L Sbjct: 518 KDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCR--LGGIKHL 575 Query: 186 VAAVVRTMQNTSDLDTARCTTSILHNLSHHR---EGLLAIFKSGGIPALVRMLSSPVESV 242 V + + L+ + L NL + E +A+ GGIPAL+R+L +++ Sbjct: 576 VDLLDHRV-----LEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAE 630 Query: 243 LFYAITTLHNLLLYQEGAKMAVRLADGLQKM-----VPLLNKNNPKF------------- 284 + +T + L + KM + + D L + VP NN F Sbjct: 631 VRELVTGVLWNLSSCDAVKMTI-IRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLV 689 Query: 285 LAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSN 344 L TT CL+ L+ +E++ + MR S E L+ +L V+ C + Sbjct: 690 LRNTTGCLRNLSSAGEEAR-------------KQMR--SCEGLV---DSLLYVIHTCVNT 731 Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDD 404 + + V+NC+ TLRNLS L++ V Q + Sbjct: 732 -----------------SDYDSKTVENCVCTLRNLS----------YRLELEVPQARLLG 764 Query: 405 VNVLTCATGTL-----SNLTCNNSKNKT------------------LVTQNSGVEALIH- 440 +N L G S +C K K L GVE L H Sbjct: 765 LNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHP 824 Query: 441 -------AILRAGDKDDITEPAVCALRHLTSRHPE-AEMAQNSVRLNYGIPAIVKLLNQP 492 +L E + +L++L++ + + A + +VR G+P +V+LL Sbjct: 825 SVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMD 884 Query: 493 NQWPLVKATIGLIRNLAL 510 N +V + +RN+AL Sbjct: 885 ND-RVVSSVATALRNMAL 901 Score = 34.7 bits (78), Expect = 0.33 Identities = 28/117 (23%), Positives = 56/117 (47%), Gaps = 13/117 (11%) Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-DVATKQEGLESVLKILVNQL--- 400 + A+ + G+ L + L ++ R+V + LRN++ DV K+ + ++ LVN+L Sbjct: 865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGG 924 Query: 401 ------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDI 451 S + + + CA L +T N +N + + G+E L++ GD+ + Sbjct: 925 NGPSVLSDETMAAICCA---LHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSL 978 Score = 30.8 bits (68), Expect = 4.8 Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 19/139 (13%) Query: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI- 439 + A + L V+ +L +Q N A L +L ++K K V + G++ L+ Sbjct: 522 EFAWRDPELPEVIHMLQHQFPSVQAN----AAAYLQHLCFGDNKVKMEVCRLGGIKHLVD 577 Query: 440 ---HAILRAGDKDDITEPAVCALRHLT--SRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQ 494 H +L ++ + A ALR+L E ++A +V GIPA+++LL + Sbjct: 578 LLDHRVL------EVQKNACGALRNLVFGKSTDENKIAMKNVG---GIPALLRLLRKSID 628 Query: 495 WPLVKATIGLIRNLALCPA 513 + + G++ NL+ C A Sbjct: 629 AEVRELVTGVLWNLSSCDA 647 >gi|53729344 plakophilin 1 isoform 1a [Homo sapiens] Length = 726 Score = 45.8 bits (107), Expect = 1e-04 Identities = 97/471 (20%), Positives = 176/471 (37%), Gaps = 62/471 (13%) Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267 I H +++ GGI LV +L SP ++V A L NL+ K+ R Sbjct: 269 IQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ 328 Query: 268 DGLQKMVPLLNK-NNPKFLAITTDCLQLLAYGNQ-------------ESKLIILANGGPQ 313 +G+++ V LL + N + T L L+ ++ ++II +G Sbjct: 329 NGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCD 388 Query: 314 ALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGG----MQALGKHLTSNS---P 366 + R ++ + + L+ LS + + + G + A ++ + S Sbjct: 389 GNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDD 448 Query: 367 RLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLT--CATGTLSNLT---CN 421 + V+NC+ L NLS L++ + QL + N T +TG SN + N Sbjct: 449 KSVENCMCVLHNLS------YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMN 502 Query: 422 NSKNKTL---VTQNSGVEALIHA--------ILRAGDKDDITEPAVCALRHLTSRH--PE 468 N+ + L T G L H+ ++ KD E AL++LT+ Sbjct: 503 NNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMS 562 Query: 469 AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLV 528 + M+Q G+P I +LL N +V++ L+ N++ P H + V P + Sbjct: 563 SGMSQLIGLKEKGLPQIARLLQSGNS-DVVRSGASLLSNMSRHPLLHRVMGN-QVFPEVT 620 Query: 529 QLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPL 588 +LL T + + C +++A P + F + + Sbjct: 621 RLL--------------TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNN 666 Query: 589 FVQLLYSSVE-NIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRN 638 + L SS A +L ++ KE + +G ++ L N Sbjct: 667 IINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGAN 717 Score = 40.4 bits (93), Expect = 0.006 Identities = 86/415 (20%), Positives = 148/415 (35%), Gaps = 87/415 (20%) Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287 IP V+ LSS E + + E AK V G+ K+V LL N Sbjct: 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQA 306 Query: 288 TTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPA 347 L+ L + + +KL G + V ++R Sbjct: 307 AAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRT------------------------- 341 Query: 348 IVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQL------- 400 G + K LT LW L + ++ K+E + L +L +++ Sbjct: 342 -----GNAEIQKQLTG--------LLWNLSSTDEL--KEELIADALPVLADRVIIPFSGW 386 Query: 401 ---------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI----HAILRAGD 447 V D V ATG L NL+ ++ +T+ + +++L+ + + + Sbjct: 387 CDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRC 446 Query: 448 KDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRN 507 D E +C L +L+ R +AE+ +L Y N N + K++ G N Sbjct: 447 DDKSVENCMCVLHNLSYR-LDAEVPTRYRQLEY---------NARNAY-TEKSSTGCFSN 495 Query: 508 LALCPANH---APLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCT 564 + N+ PL E P+ L H DA R T + + +E C Sbjct: 496 KSDKMMNNNYDCPLPEEETNPKGSGWLY--HSDAIR-----TYLNLMGKSKKDATLEACA 548 Query: 565 GALHILARDP------MNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQ 613 GAL L M+++ + +P +LL S ++ R A +L +++ Sbjct: 549 GALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 603 >gi|169218113 PREDICTED: similar to plakophilin 1, partial [Homo sapiens] Length = 625 Score = 45.8 bits (107), Expect = 1e-04 Identities = 97/471 (20%), Positives = 176/471 (37%), Gaps = 62/471 (13%) Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267 I H +++ GGI LV +L SP ++V A L NL+ K+ R Sbjct: 168 IQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ 227 Query: 268 DGLQKMVPLLNK-NNPKFLAITTDCLQLLAYGNQ-------------ESKLIILANGGPQ 313 +G+++ V LL + N + T L L+ ++ ++II +G Sbjct: 228 NGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCD 287 Query: 314 ALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGG----MQALGKHLTSNS---P 366 + R ++ + + L+ LS + + + G + A ++ + S Sbjct: 288 GNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDD 347 Query: 367 RLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLT--CATGTLSNLT---CN 421 + V+NC+ L NLS L++ + QL + N T +TG SN + N Sbjct: 348 KSVENCMCVLHNLS------YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMN 401 Query: 422 NSKNKTL---VTQNSGVEALIHA--------ILRAGDKDDITEPAVCALRHLTSRH--PE 468 N+ + L T G L H+ ++ KD E AL++LT+ Sbjct: 402 NNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMS 461 Query: 469 AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLV 528 + M+Q G+P I +LL N +V++ L+ N++ P H + V P + Sbjct: 462 SGMSQLIGLKEKGLPQIARLLQSGNS-DVVRSGASLLSNMSRHPLLHRVMGN-QVFPEVT 519 Query: 529 QLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPL 588 +LL T + + C +++A P + F + + Sbjct: 520 RLL--------------TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNN 565 Query: 589 FVQLLYSSVE-NIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRN 638 + L SS A +L ++ KE + +G ++ L N Sbjct: 566 IINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGAN 616 Score = 40.4 bits (93), Expect = 0.006 Identities = 86/415 (20%), Positives = 148/415 (35%), Gaps = 87/415 (20%) Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287 IP V+ LSS E + + E AK V G+ K+V LL N Sbjct: 146 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQA 205 Query: 288 TTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPA 347 L+ L + + +KL G + V ++R Sbjct: 206 AAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRT------------------------- 240 Query: 348 IVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQL------- 400 G + K LT LW L + ++ K+E + L +L +++ Sbjct: 241 -----GNAEIQKQLTG--------LLWNLSSTDEL--KEELIADALPVLADRVIIPFSGW 285 Query: 401 ---------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI----HAILRAGD 447 V D V ATG L NL+ ++ +T+ + +++L+ + + + Sbjct: 286 CDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRC 345 Query: 448 KDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRN 507 D E +C L +L+ R +AE+ +L Y N N + K++ G N Sbjct: 346 DDKSVENCMCVLHNLSYR-LDAEVPTRYRQLEY---------NARNAY-TEKSSTGCFSN 394 Query: 508 LALCPANH---APLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCT 564 + N+ PL E P+ L H DA R T + + +E C Sbjct: 395 KSDKMMNNNYDCPLPEEETNPKGSGWLY--HSDAIR-----TYLNLMGKSKKDATLEACA 447 Query: 565 GALHILARDP------MNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQ 613 GAL L M+++ + +P +LL S ++ R A +L +++ Sbjct: 448 GALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 502 >gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens] Length = 379 Score = 45.4 bits (106), Expect = 2e-04 Identities = 42/169 (24%), Positives = 72/169 (42%), Gaps = 13/169 (7%) Query: 80 ARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLIN-----YQ 134 ARA R R A+ S +L+ Q + L ++E +L++A++ L N + Sbjct: 96 ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155 Query: 135 DDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLS-KKEASRRALMGSPQLVAAVVRTM 193 D LP + K+LN DP+V KA +++N LS E RR + Q+ + + Sbjct: 156 RDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSR 215 Query: 194 QNTSD-------LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRML 235 N+S L T H L++ +F +G +++L Sbjct: 216 LNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVL 264 Score = 32.0 bits (71), Expect = 2.1 Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 10/104 (9%) Query: 344 NKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVD 403 N+ I + GG+ + K L + P + + L L NLS A Q LK+ +NQ+ D Sbjct: 155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRR----LKVYMNQVCDD 210 Query: 404 DV------NVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHA 441 + +V L+N+T N L S L A Sbjct: 211 TITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSA 254 >gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens] Length = 379 Score = 45.4 bits (106), Expect = 2e-04 Identities = 42/169 (24%), Positives = 72/169 (42%), Gaps = 13/169 (7%) Query: 80 ARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLIN-----YQ 134 ARA R R A+ S +L+ Q + L ++E +L++A++ L N + Sbjct: 96 ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155 Query: 135 DDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLS-KKEASRRALMGSPQLVAAVVRTM 193 D LP + K+LN DP+V KA +++N LS E RR + Q+ + + Sbjct: 156 RDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSR 215 Query: 194 QNTSD-------LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRML 235 N+S L T H L++ +F +G +++L Sbjct: 216 LNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVL 264 Score = 32.0 bits (71), Expect = 2.1 Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 10/104 (9%) Query: 344 NKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVD 403 N+ I + GG+ + K L + P + + L L NLS A Q LK+ +NQ+ D Sbjct: 155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRR----LKVYMNQVCDD 210 Query: 404 DV------NVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHA 441 + +V L+N+T N L S L A Sbjct: 211 TITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSA 254 >gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens] Length = 379 Score = 45.4 bits (106), Expect = 2e-04 Identities = 42/169 (24%), Positives = 72/169 (42%), Gaps = 13/169 (7%) Query: 80 ARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLIN-----YQ 134 ARA R R A+ S +L+ Q + L ++E +L++A++ L N + Sbjct: 96 ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155 Query: 135 DDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLS-KKEASRRALMGSPQLVAAVVRTM 193 D LP + K+LN DP+V KA +++N LS E RR + Q+ + + Sbjct: 156 RDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSR 215 Query: 194 QNTSD-------LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRML 235 N+S L T H L++ +F +G +++L Sbjct: 216 LNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVL 264 Score = 32.0 bits (71), Expect = 2.1 Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 10/104 (9%) Query: 344 NKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVD 403 N+ I + GG+ + K L + P + + L L NLS A Q LK+ +NQ+ D Sbjct: 155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRR----LKVYMNQVCDD 210 Query: 404 DV------NVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHA 441 + +V L+N+T N L S L A Sbjct: 211 TITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSA 254 >gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens] Length = 2303 Score = 45.1 bits (105), Expect = 2e-04 Identities = 82/339 (24%), Positives = 143/339 (42%), Gaps = 47/339 (13%) Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203 E+ K+ D + + + A M + L+ + + +A + + + + A+V + + S+ + + Sbjct: 449 EMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLASDSE-ELHQ 507 Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVR-MLSSPVESVLFYAITTLHNLLLYQEGA 260 +SIL NLS + + ++G + ALV+ +L + ES L ++ L NL + Sbjct: 508 VVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLKSVLSALWNLSAHSTEN 567 Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320 K A+ DG FL T L Y Q + L I+ +GG I+R Sbjct: 568 KAAICQVDGALG-----------FLVST------LTYKCQSNSLAIIESGGG-----ILR 605 Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380 N S L+ T +VL + +Q L +HLTS+S +V N TL NLS Sbjct: 606 NVS--SLVATREDYRQVLR----------DHNCLQTLLQHLTSHSLTIVSNACGTLWNLS 653 Query: 381 DVATKQE------GLESVLKILV-NQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNS 433 + + + G +L+ LV ++ + + L++ + T V+ S Sbjct: 654 ARSARDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGS 713 Query: 434 GVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMA 472 V +L RA + + AL HL + P A A Sbjct: 714 CVPSLYVRKQRALEAELDARHLAQALEHLEKQGPPAAEA 752 Score = 32.7 bits (73), Expect = 1.3 Identities = 62/253 (24%), Positives = 99/253 (39%), Gaps = 41/253 (16%) Query: 352 GGMQALGKHLTSNSPRLVQNCLWTLRNLS---DVATKQEGLE--SVLKILVNQLSVDDVN 406 G M+A+ L S+S L Q LRNLS D+ +K+ E SV ++ L + Sbjct: 489 GCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKES 548 Query: 407 VLTCATGTLSNLTCNNSKNKTLVTQNSG-----VEALIH-------AILRAG-------- 446 L L NL+ ++++NK + Q G V L + AI+ +G Sbjct: 549 TLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVS 608 Query: 447 -------DKDDITEPAVCA---LRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWP 496 D + C L+HLTS + N+ + + A +Q W Sbjct: 609 SLVATREDYRQVLRDHNCLQTLLQHLTSH--SLTIVSNACGTLWNLSAR-SARDQELLWD 665 Query: 497 LVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRM 556 L +G++RNL + AA + L+ HQ A V+ G+ P + VR Sbjct: 666 L--GAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVP-SLYVRK 722 Query: 557 EEIVEGCTGALHI 569 + +E A H+ Sbjct: 723 QRALEAELDARHL 735 >gi|189011568 adenomatous polyposis coli [Homo sapiens] Length = 2843 Score = 44.3 bits (103), Expect = 4e-04 Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 33/306 (10%) Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVR-- 265 +L LS E A+ + GG+ A+ +L E Y +T H + + A MA+ Sbjct: 452 VLMKLSFDEEHRHAMNELGGLQAIAELLQVDCE---MYGLTNDHYSITLRRYAGMALTNL 508 Query: 266 -------------LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGG 311 + ++ +V L + + L+ L++ + SK + G Sbjct: 509 TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS 568 Query: 312 PQALVQIMRNYSYEKLLWTTSRVLKVLSV-CPSNKPAIVEAGGMQA-----LGKHLTSNS 365 +AL++ E L + L LS C NK I G A L +N+ Sbjct: 569 VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNT 628 Query: 366 PRLVQNCLWTLRNLSDVATKQEGLESVLK------ILVNQLSVDDVNVLTCATGTLSNLT 419 ++++ LRN+S + E +L+ L+ L + +++ A GTL NL+ Sbjct: 629 LAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688 Query: 420 CNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLN 479 N K++ + + G +++ ++ + K I + ALR+L + P N + Sbjct: 689 ARNPKDQEAL-WDMGAVSMLKNLIHSKHK-MIAMGSAAALRNLMANRPAKYKDANIMSPG 746 Query: 480 YGIPAI 485 +P++ Sbjct: 747 SSLPSL 752 Score = 40.8 bits (94), Expect = 0.005 Identities = 65/264 (24%), Positives = 112/264 (42%), Gaps = 46/264 (17%) Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203 E+ L ND + + + A M + L+ + + +A + S + + A+V +++ S+ D + Sbjct: 484 EMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESE-DLQQ 542 Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVRM-LSSPVESVLFYAITTLHNLLLYQEGA 260 S+L NLS + + + G + AL+ L ES L ++ L NL + Sbjct: 543 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 602 Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320 K + DG FL T L Y +Q + L I+ +GG I+R Sbjct: 603 KADICAVDGALA-----------FLVGT------LTYRSQTNTLAIIESGGG-----ILR 640 Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380 N S +++ ++ + E +Q L +HL S+S +V N TL NLS Sbjct: 641 NVS------------SLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688 Query: 381 DVATKQE------GLESVLKILVN 398 K + G S+LK L++ Sbjct: 689 ARNPKDQEALWDMGAVSMLKNLIH 712 >gi|189011566 adenomatous polyposis coli [Homo sapiens] Length = 2843 Score = 44.3 bits (103), Expect = 4e-04 Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 33/306 (10%) Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVR-- 265 +L LS E A+ + GG+ A+ +L E Y +T H + + A MA+ Sbjct: 452 VLMKLSFDEEHRHAMNELGGLQAIAELLQVDCE---MYGLTNDHYSITLRRYAGMALTNL 508 Query: 266 -------------LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGG 311 + ++ +V L + + L+ L++ + SK + G Sbjct: 509 TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS 568 Query: 312 PQALVQIMRNYSYEKLLWTTSRVLKVLSV-CPSNKPAIVEAGGMQA-----LGKHLTSNS 365 +AL++ E L + L LS C NK I G A L +N+ Sbjct: 569 VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNT 628 Query: 366 PRLVQNCLWTLRNLSDVATKQEGLESVLK------ILVNQLSVDDVNVLTCATGTLSNLT 419 ++++ LRN+S + E +L+ L+ L + +++ A GTL NL+ Sbjct: 629 LAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688 Query: 420 CNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLN 479 N K++ + + G +++ ++ + K I + ALR+L + P N + Sbjct: 689 ARNPKDQEAL-WDMGAVSMLKNLIHSKHK-MIAMGSAAALRNLMANRPAKYKDANIMSPG 746 Query: 480 YGIPAI 485 +P++ Sbjct: 747 SSLPSL 752 Score = 40.8 bits (94), Expect = 0.005 Identities = 65/264 (24%), Positives = 112/264 (42%), Gaps = 46/264 (17%) Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203 E+ L ND + + + A M + L+ + + +A + S + + A+V +++ S+ D + Sbjct: 484 EMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESE-DLQQ 542 Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVRM-LSSPVESVLFYAITTLHNLLLYQEGA 260 S+L NLS + + + G + AL+ L ES L ++ L NL + Sbjct: 543 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 602 Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320 K + DG FL T L Y +Q + L I+ +GG I+R Sbjct: 603 KADICAVDGALA-----------FLVGT------LTYRSQTNTLAIIESGGG-----ILR 640 Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380 N S +++ ++ + E +Q L +HL S+S +V N TL NLS Sbjct: 641 NVS------------SLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688 Query: 381 DVATKQE------GLESVLKILVN 398 K + G S+LK L++ Sbjct: 689 ARNPKDQEALWDMGAVSMLKNLIH 712 >gi|53759122 adenomatous polyposis coli [Homo sapiens] Length = 2843 Score = 44.3 bits (103), Expect = 4e-04 Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 33/306 (10%) Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVR-- 265 +L LS E A+ + GG+ A+ +L E Y +T H + + A MA+ Sbjct: 452 VLMKLSFDEEHRHAMNELGGLQAIAELLQVDCE---MYGLTNDHYSITLRRYAGMALTNL 508 Query: 266 -------------LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGG 311 + ++ +V L + + L+ L++ + SK + G Sbjct: 509 TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS 568 Query: 312 PQALVQIMRNYSYEKLLWTTSRVLKVLSV-CPSNKPAIVEAGGMQA-----LGKHLTSNS 365 +AL++ E L + L LS C NK I G A L +N+ Sbjct: 569 VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNT 628 Query: 366 PRLVQNCLWTLRNLSDVATKQEGLESVLK------ILVNQLSVDDVNVLTCATGTLSNLT 419 ++++ LRN+S + E +L+ L+ L + +++ A GTL NL+ Sbjct: 629 LAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688 Query: 420 CNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLN 479 N K++ + + G +++ ++ + K I + ALR+L + P N + Sbjct: 689 ARNPKDQEAL-WDMGAVSMLKNLIHSKHK-MIAMGSAAALRNLMANRPAKYKDANIMSPG 746 Query: 480 YGIPAI 485 +P++ Sbjct: 747 SSLPSL 752 Score = 40.8 bits (94), Expect = 0.005 Identities = 65/264 (24%), Positives = 112/264 (42%), Gaps = 46/264 (17%) Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203 E+ L ND + + + A M + L+ + + +A + S + + A+V +++ S+ D + Sbjct: 484 EMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESE-DLQQ 542 Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVRM-LSSPVESVLFYAITTLHNLLLYQEGA 260 S+L NLS + + + G + AL+ L ES L ++ L NL + Sbjct: 543 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 602 Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320 K + DG FL T L Y +Q + L I+ +GG I+R Sbjct: 603 KADICAVDGALA-----------FLVGT------LTYRSQTNTLAIIESGGG-----ILR 640 Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380 N S +++ ++ + E +Q L +HL S+S +V N TL NLS Sbjct: 641 NVS------------SLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688 Query: 381 DVATKQE------GLESVLKILVN 398 K + G S+LK L++ Sbjct: 689 ARNPKDQEALWDMGAVSMLKNLIH 712 >gi|224589129 karyopherin 7 [Homo sapiens] Length = 516 Score = 43.9 bits (102), Expect = 5e-04 Identities = 94/413 (22%), Positives = 159/413 (38%), Gaps = 78/413 (18%) Query: 270 LQKMVPLLNKNNPK--FLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKL 327 L +++ +N ++P F A T L N KL+I A P+ +V+ +++ Y L Sbjct: 72 LGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPR-MVEFLKSSLYPCL 130 Query: 328 LWTTSRVL-KVLSVCPSNKPAIVEAGGMQALGKHLTSN---------------------- 364 + + L + S A+VE G +Q L + L+S+ Sbjct: 131 QFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEF 190 Query: 365 -----------------SPRL----VQNCLWTLRNL--------SDVATKQEGLESVLKI 395 SP L ++N WTL NL D A KQ +L Sbjct: 191 RDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQ-----ILPA 245 Query: 396 LVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPA 455 L++ L D VL+ A LS LT ++K V N+GV + ++ + + + +T Sbjct: 246 LLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVV-NTGVLPRLVVLMTSSELNVLTPSL 304 Query: 456 VCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANH 515 +T + +MA ++ LN ++ L Q N+ + K + N+A P +H Sbjct: 305 RTVGNIVTGTDEQTQMAIDAGMLN-----VLPQLLQHNKPSIQKEAAWALSNVAAGPCHH 359 Query: 516 -APLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVE----GCTGALHIL 570 L V+P LV LL Q+ A + G M+++++ G L L Sbjct: 360 IQQLLAYDVLPPLVALLKNGEFKVQKE-AVWMVANFATGATMDQLIQLVHSGVLEPLVNL 418 Query: 571 ARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDA 623 P ++ + L+ I +Q E LC L ++ D I+A Sbjct: 419 LTAPDVKIVLIILDVISCILQAAEKRSEKEN------LCLLIEELGGIDRIEA 465 Score = 35.0 bits (79), Expect = 0.25 Identities = 48/230 (20%), Positives = 89/230 (38%), Gaps = 4/230 (1%) Query: 222 IFKSGGIPALVRMLSSPVESVLFYAIT-TLHNLLLYQEGAKMAVRLADGLQKMVPLLNKN 280 + S IP L+ ++S + IT TL NL + + L ++ LL Sbjct: 194 VITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQ 253 Query: 281 NPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSV 340 + + L+ L L G+ + ++ G LV +M + L + V +++ Sbjct: 254 DSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTG 313 Query: 341 CPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVA---TKQEGLESVLKILV 397 ++AG + L + L N P + + W L N++ +Q VL LV Sbjct: 314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLV 373 Query: 398 NQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGD 447 L + V A ++N + ++ + +SGV + +L A D Sbjct: 374 ALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPD 423 Score = 33.1 bits (74), Expect = 0.96 Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 6/98 (6%) Query: 580 IFRLNTIPLFVQLLYSSVEN-IQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR 637 + IP V+ L SS+ +Q AA L +A E A+ GA PL+ELL S Sbjct: 109 VIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSS 168 Query: 638 NEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKH 675 N A L I+ D P++R V +T++ H Sbjct: 169 NVAVCEQAVWALGNIAGD-GPEFRDNV---ITSNAIPH 202 >gi|6005830 plakophilin 3 [Homo sapiens] Length = 797 Score = 42.4 bits (98), Expect = 0.002 Identities = 51/217 (23%), Positives = 89/217 (41%), Gaps = 21/217 (9%) Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLW 329 L V L ++P + +Q Y + +K + LV++ + + E Sbjct: 321 LPSAVKYLMASDPNLQVLGAAYIQHKCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRH 380 Query: 330 TTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDV-----AT 384 T + ++ NK A+VE G+ L + L L +N L NLS Sbjct: 381 ATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELRKNVTGILWNLSSSDHLKDRL 440 Query: 385 KQEGLESVLKILVNQLS-----------VDDVNVLTCATGTLSNLTCNNSKNKTLVTQNS 433 ++ LE + ++++ LS + + ATG L NL+ + + + + Sbjct: 441 ARDTLEQLTDLVLSPLSGAGGPPLIQQNASEAEIFYNATGFLRNLSSASQATRQKMRECH 500 Query: 434 G-VEALIHAILRAGD----KDDITEPAVCALRHLTSR 465 G V+AL+ +I A D +D E AVC LR+L+ R Sbjct: 501 GLVDALVTSINHALDAGKCEDKSVENAVCVLRNLSYR 537 >gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [Homo sapiens] Length = 607 Score = 40.8 bits (94), Expect = 0.005 Identities = 92/422 (21%), Positives = 160/422 (37%), Gaps = 66/422 (15%) Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323 + +V LLN + + L T L + Y + E + + GG Q ++ +R+ + Sbjct: 92 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151 Query: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380 EKLL ++ + S + ++ G + L K L + L + CL NL+ Sbjct: 152 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 211 Query: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434 ++ + +E E ++K+ Q+ D ++ L+ N K + + Sbjct: 212 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 267 Query: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483 VE L+ + + D +DDITE V L S E + SV R+ IP Sbjct: 268 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 327 Query: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543 + N L A I N A AN + + ++ +L+ LL RHV Sbjct: 328 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 372 Query: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603 G + AL LA +N+ ++ ++ L S + +Q Sbjct: 373 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422 Query: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655 G L L +EAA+ + G + L+E L H+ G + + L R S+ Sbjct: 423 LLGTLRMLIDAQEAAEQL---GKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479 Query: 656 KN 657 K+ Sbjct: 480 KD 481 >gi|54607053 GCN1 general control of amino-acid synthesis 1-like 1 [Homo sapiens] Length = 2671 Score = 39.3 bits (90), Expect = 0.013 Identities = 40/132 (30%), Positives = 60/132 (45%), Gaps = 13/132 (9%) Query: 266 LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQALVQIMRNYSY 324 L D K + + PK+L C LL Y + E K +IL P ++R S Sbjct: 223 LLDFYMKNILMSKVKPPKYLL--DSCAPLLRYLSHSEFKDLIL----PTIQKSLLR--SP 274 Query: 325 EKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVAT 384 E ++ T S +L +++ S + G L HL SNSPRL+ + LRNL+ + Sbjct: 275 ENVIETISSLLASVTLDLSQYAMDIVKG----LAGHLKSNSPRLMDEAVLALRNLARQCS 330 Query: 385 KQEGLESVLKIL 396 +ES+ K L Sbjct: 331 DSSAMESLTKHL 342 >gi|6912478 karyopherin alpha 6 [Homo sapiens] Length = 536 Score = 38.1 bits (87), Expect = 0.030 Identities = 77/365 (21%), Positives = 139/365 (38%), Gaps = 32/365 (8%) Query: 107 EGQATNLQRLAEPSQLLKSAIVHLIN-------------YQDDAELATRALPELTKLLND 153 E + L++ QL K V LIN Y + E+ ++L Sbjct: 32 EEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITREMVEMLFS 91 Query: 154 EDPVVVTKAAMIVNQLSKKEASRRA--LMGSPQLVAAVVRTMQN----TSDLDTARCTTS 207 +D + +L KE S ++ +P++V V ++ T + A T+ Sbjct: 92 DDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTN 151 Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267 I S + + ++G +P + +L+S E V A+ L N+ + V Sbjct: 152 IASGTSQQTK---IVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNC 208 Query: 268 DGLQKMVPLLNKNNPKFLAITTDC---LQLLAYGNQESKLIILANGGPQALVQIMRNYSY 324 L ++ LL K+ L +T + L L G + L +++ + S Sbjct: 209 SILNPLLTLLTKSTR--LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFS-SD 265 Query: 325 EKLLWTTSRVLKVLSVCPSNK-PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNL---S 380 LL L LS P+ K A++++G + L + L N ++ L + N+ Sbjct: 266 SDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGD 325 Query: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIH 440 D+ T+ S L L++ LS ++ A T+SN+T N V + LI Sbjct: 326 DIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIE 385 Query: 441 AILRA 445 + +A Sbjct: 386 ILQKA 390 Score = 31.2 bits (69), Expect = 3.7 Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 2/81 (2%) Query: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAA-DAIDAEGASAPLMELLHSRN 638 + +P+F++LL S E++Q A L +A D D + PL+ LL Sbjct: 163 VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKST 222 Query: 639 EGTATYAAA-VLFRISEDKNP 658 T T A L + KNP Sbjct: 223 RLTMTRNAVWALSNLCRGKNP 243 >gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [Homo sapiens] Length = 607 Score = 37.7 bits (86), Expect = 0.039 Identities = 91/422 (21%), Positives = 159/422 (37%), Gaps = 65/422 (15%) Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323 + +V LLN + + L T L + Y + E + + GG Q ++ +R+ + Sbjct: 91 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 150 Query: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380 EKLL ++ + S + ++ G + L K L + L + CL NL+ Sbjct: 151 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 210 Query: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434 ++ + +E E ++K+ Q+ D ++ L+ N K + + Sbjct: 211 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 266 Query: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483 VE L+ + + D +DDITE V L S E + SV R+ IP Sbjct: 267 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 326 Query: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543 + N L A I N A AN + + ++ +L+ LL RHV Sbjct: 327 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 371 Query: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603 G + AL LA +N+ ++ ++ L S + +Q Sbjct: 372 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 421 Query: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655 G L L + A+A + G + L+E L H+ G + + L R S+ Sbjct: 422 LLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479 Query: 656 KN 657 K+ Sbjct: 480 KD 481 >gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [Homo sapiens] Length = 608 Score = 37.7 bits (86), Expect = 0.039 Identities = 91/422 (21%), Positives = 159/422 (37%), Gaps = 65/422 (15%) Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323 + +V LLN + + L T L + Y + E + + GG Q ++ +R+ + Sbjct: 92 ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151 Query: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380 EKLL ++ + S + ++ G + L K L + L + CL NL+ Sbjct: 152 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 211 Query: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434 ++ + +E E ++K+ Q+ D ++ L+ N K + + Sbjct: 212 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 267 Query: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483 VE L+ + + D +DDITE V L S E + SV R+ IP Sbjct: 268 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 327 Query: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543 + N L A I N A AN + + ++ +L+ LL RHV Sbjct: 328 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 372 Query: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603 G + AL LA +N+ ++ ++ L S + +Q Sbjct: 373 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422 Query: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655 G L L + A+A + G + L+E L H+ G + + L R S+ Sbjct: 423 LLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 480 Query: 656 KN 657 K+ Sbjct: 481 KD 482 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.316 0.131 0.374 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 26,267,538 Number of Sequences: 37866 Number of extensions: 1081431 Number of successful extensions: 2939 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 24 Number of HSP's successfully gapped in prelim test: 49 Number of HSP's that attempted gapping in prelim test: 2614 Number of HSP's gapped (non-prelim): 255 length of query: 745 length of database: 18,247,518 effective HSP length: 110 effective length of query: 635 effective length of database: 14,082,258 effective search space: 8942233830 effective search space used: 8942233830 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.