Guide to the Human Genome
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Search of human proteins with 4504811

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504811 junction plakoglobin [Homo sapiens]
         (745 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504811 junction plakoglobin [Homo sapiens]                       1469   0.0  
gi|12056468 junction plakoglobin [Homo sapiens]                      1469   0.0  
gi|148227672 catenin (cadherin-associated protein), beta 1, 88kD...   952   0.0  
gi|148233338 catenin (cadherin-associated protein), beta 1, 88kD...   952   0.0  
gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa ...   952   0.0  
gi|31657114 armadillo repeat containing 4 [Homo sapiens]               77   8e-14
gi|189409124 armadillo repeat containing 3 [Homo sapiens]              76   1e-13
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]     57   6e-08
gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]     53   1e-06
gi|11034811 catenin (cadherin-associated protein), delta 2 (neur...    52   2e-06
gi|4504897 karyopherin alpha 2 [Homo sapiens]                          51   3e-06
gi|4502247 armadillo repeat protein [Homo sapiens]                     51   4e-06
gi|53829376 plakophilin 4 isoform b [Homo sapiens]                     46   1e-04
gi|53829374 plakophilin 4 isoform a [Homo sapiens]                     46   1e-04
gi|53729344 plakophilin 1 isoform 1a [Homo sapiens]                    46   1e-04
gi|169218113 PREDICTED: similar to plakophilin 1, partial [Homo ...    46   1e-04
gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens]     45   2e-04
gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens]     45   2e-04
gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens]      45   2e-04
gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]                45   2e-04
gi|189011568 adenomatous polyposis coli [Homo sapiens]                 44   4e-04
gi|189011566 adenomatous polyposis coli [Homo sapiens]                 44   4e-04
gi|53759122 adenomatous polyposis coli [Homo sapiens]                  44   4e-04
gi|224589129 karyopherin 7 [Homo sapiens]                              44   5e-04
gi|6005830 plakophilin 3 [Homo sapiens]                                42   0.002
gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2 [...    41   0.005
gi|54607053 GCN1 general control of amino-acid synthesis 1-like ...    39   0.013
gi|6912478 karyopherin alpha 6 [Homo sapiens]                          38   0.030
gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3 [...    38   0.039
gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1 [...    38   0.039

>gi|4504811 junction plakoglobin [Homo sapiens]
          Length = 745

 Score = 1469 bits (3804), Expect = 0.0
 Identities = 745/745 (100%), Positives = 745/745 (100%)

Query: 1   MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60
           MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT
Sbjct: 1   MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60

Query: 61  YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120
           YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS
Sbjct: 61  YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120

Query: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180
           QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
Sbjct: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180

Query: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240
           GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE
Sbjct: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240

Query: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300
           SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ
Sbjct: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300

Query: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360
           ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH
Sbjct: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360

Query: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420
           LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC
Sbjct: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420

Query: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480
           NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY
Sbjct: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480

Query: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540
           GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR
Sbjct: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540

Query: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600
           HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI
Sbjct: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600

Query: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660
           QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY
Sbjct: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660

Query: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720
           RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM
Sbjct: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720

Query: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745
           DGDYPIDTYSDGLRPPYPTADHMLA
Sbjct: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745


>gi|12056468 junction plakoglobin [Homo sapiens]
          Length = 745

 Score = 1469 bits (3804), Expect = 0.0
 Identities = 745/745 (100%), Positives = 745/745 (100%)

Query: 1   MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60
           MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT
Sbjct: 1   MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTT 60

Query: 61  YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120
           YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS
Sbjct: 61  YTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPS 120

Query: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180
           QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
Sbjct: 121 QLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM 180

Query: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240
           GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE
Sbjct: 181 GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVE 240

Query: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300
           SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ
Sbjct: 241 SVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ 300

Query: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360
           ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH
Sbjct: 301 ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKH 360

Query: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420
           LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC
Sbjct: 361 LTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTC 420

Query: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480
           NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY
Sbjct: 421 NNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNY 480

Query: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540
           GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR
Sbjct: 481 GIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQR 540

Query: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600
           HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI
Sbjct: 541 HVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENI 600

Query: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660
           QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY
Sbjct: 601 QRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDY 660

Query: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720
           RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM
Sbjct: 661 RKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDMDATYRPMYSSDVPLDPLEMHMDM 720

Query: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745
           DGDYPIDTYSDGLRPPYPTADHMLA
Sbjct: 721 DGDYPIDTYSDGLRPPYPTADHMLA 745


>gi|148227672 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score =  952 bits (2462), Expect = 0.0
 Identities = 511/749 (68%), Positives = 585/749 (78%), Gaps = 19/749 (2%)

Query: 1   MEVMNLMEQPIK--VTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKT 58
           ME+   ME   K  V+ WQQ    DSGIHSGA T  PS+S KG  EE++    Q   +  
Sbjct: 8   MELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWE 67

Query: 59  TTYTQGVPPSQ-GDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLA 117
             ++Q     Q  D++ Q + T RA+RVR AM P    E   +          TN+QRLA
Sbjct: 68  QGFSQSFTQEQVADIDGQYAMT-RAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLA 126

Query: 118 EPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRR 177
           EPSQ+LK A+V+LINYQDDAELATRA+PELTKLLNDED VVV KAA++V+QLSKKEASR 
Sbjct: 127 EPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRH 186

Query: 178 ALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSS 237
           A+M SPQ+V+A+VRTMQNT+D++TARCT   LHNLSHHREGLLAIFKSGGIPALV+ML S
Sbjct: 187 AIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS 246

Query: 238 PVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAY 297
           PV+SVLFYAITTLHNLLL+QEGAKMAVRLA GLQKMV LLNK N KFLAITTDCLQ+LAY
Sbjct: 247 PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY 306

Query: 298 GNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357
           GNQESKLIILA+GGPQALV IMR Y+YEKLLWTTSRVLKVLSVC SNKPAIVEAGGMQAL
Sbjct: 307 GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366

Query: 358 GKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417
           G HLT  S RLVQNCLWTLRNLSD ATKQEG+E +L  LV  L  DD+NV+TCA G LSN
Sbjct: 367 GLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSN 426

Query: 418 LTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVR 477
           LTCNN KNK +V Q  G+EAL+  +LRAGD++DITEPA+CALRHLTSRH EAEMAQN+VR
Sbjct: 427 LTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVR 486

Query: 478 LNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQD 537
           L+YG+P +VKLL+ P+ WPL+KAT+GLIRNLALCPANHAPL+E   IPRLVQLLV+AHQD
Sbjct: 487 LHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD 546

Query: 538 AQRHVA-AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSS 596
            QR  +  GTQQ + +GVRMEEIVEGCTGALHILARD  NR+ I  LNTIPLFVQLLYS 
Sbjct: 547 TQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP 606

Query: 597 VENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656
           +ENIQRVAAGVLCELAQDKEAA+AI+AEGA+APL ELLHSRNEG ATYAAAVLFR+SEDK
Sbjct: 607 IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDK 666

Query: 657 NPDYRKRVSVELTNSLFKHDPAAW-EAAQSMIPI---NEPYG-DDMDATYRPMYSSDVPL 711
             DY+KR+SVELT+SLF+ +P AW E A   + I    EP G    D +YR  +S     
Sbjct: 667 PQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQ 726

Query: 712 DPLEMHMDMD---------GDYPIDTYSD 731
           D L M   M+          DYP+D   D
Sbjct: 727 DALGMDPMMEHEMGGHHPGADYPVDGLPD 755


>gi|148233338 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score =  952 bits (2462), Expect = 0.0
 Identities = 511/749 (68%), Positives = 585/749 (78%), Gaps = 19/749 (2%)

Query: 1   MEVMNLMEQPIK--VTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKT 58
           ME+   ME   K  V+ WQQ    DSGIHSGA T  PS+S KG  EE++    Q   +  
Sbjct: 8   MELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWE 67

Query: 59  TTYTQGVPPSQ-GDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLA 117
             ++Q     Q  D++ Q + T RA+RVR AM P    E   +          TN+QRLA
Sbjct: 68  QGFSQSFTQEQVADIDGQYAMT-RAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLA 126

Query: 118 EPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRR 177
           EPSQ+LK A+V+LINYQDDAELATRA+PELTKLLNDED VVV KAA++V+QLSKKEASR 
Sbjct: 127 EPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRH 186

Query: 178 ALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSS 237
           A+M SPQ+V+A+VRTMQNT+D++TARCT   LHNLSHHREGLLAIFKSGGIPALV+ML S
Sbjct: 187 AIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS 246

Query: 238 PVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAY 297
           PV+SVLFYAITTLHNLLL+QEGAKMAVRLA GLQKMV LLNK N KFLAITTDCLQ+LAY
Sbjct: 247 PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY 306

Query: 298 GNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357
           GNQESKLIILA+GGPQALV IMR Y+YEKLLWTTSRVLKVLSVC SNKPAIVEAGGMQAL
Sbjct: 307 GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366

Query: 358 GKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417
           G HLT  S RLVQNCLWTLRNLSD ATKQEG+E +L  LV  L  DD+NV+TCA G LSN
Sbjct: 367 GLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSN 426

Query: 418 LTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVR 477
           LTCNN KNK +V Q  G+EAL+  +LRAGD++DITEPA+CALRHLTSRH EAEMAQN+VR
Sbjct: 427 LTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVR 486

Query: 478 LNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQD 537
           L+YG+P +VKLL+ P+ WPL+KAT+GLIRNLALCPANHAPL+E   IPRLVQLLV+AHQD
Sbjct: 487 LHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD 546

Query: 538 AQRHVA-AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSS 596
            QR  +  GTQQ + +GVRMEEIVEGCTGALHILARD  NR+ I  LNTIPLFVQLLYS 
Sbjct: 547 TQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP 606

Query: 597 VENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656
           +ENIQRVAAGVLCELAQDKEAA+AI+AEGA+APL ELLHSRNEG ATYAAAVLFR+SEDK
Sbjct: 607 IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDK 666

Query: 657 NPDYRKRVSVELTNSLFKHDPAAW-EAAQSMIPI---NEPYG-DDMDATYRPMYSSDVPL 711
             DY+KR+SVELT+SLF+ +P AW E A   + I    EP G    D +YR  +S     
Sbjct: 667 PQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQ 726

Query: 712 DPLEMHMDMD---------GDYPIDTYSD 731
           D L M   M+          DYP+D   D
Sbjct: 727 DALGMDPMMEHEMGGHHPGADYPVDGLPD 755


>gi|4503131 catenin (cadherin-associated protein), beta 1, 88kDa
           [Homo sapiens]
          Length = 781

 Score =  952 bits (2462), Expect = 0.0
 Identities = 511/749 (68%), Positives = 585/749 (78%), Gaps = 19/749 (2%)

Query: 1   MEVMNLMEQPIK--VTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKT 58
           ME+   ME   K  V+ WQQ    DSGIHSGA T  PS+S KG  EE++    Q   +  
Sbjct: 8   MELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWE 67

Query: 59  TTYTQGVPPSQ-GDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLA 117
             ++Q     Q  D++ Q + T RA+RVR AM P    E   +          TN+QRLA
Sbjct: 68  QGFSQSFTQEQVADIDGQYAMT-RAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLA 126

Query: 118 EPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRR 177
           EPSQ+LK A+V+LINYQDDAELATRA+PELTKLLNDED VVV KAA++V+QLSKKEASR 
Sbjct: 127 EPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRH 186

Query: 178 ALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSS 237
           A+M SPQ+V+A+VRTMQNT+D++TARCT   LHNLSHHREGLLAIFKSGGIPALV+ML S
Sbjct: 187 AIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS 246

Query: 238 PVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAY 297
           PV+SVLFYAITTLHNLLL+QEGAKMAVRLA GLQKMV LLNK N KFLAITTDCLQ+LAY
Sbjct: 247 PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAY 306

Query: 298 GNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357
           GNQESKLIILA+GGPQALV IMR Y+YEKLLWTTSRVLKVLSVC SNKPAIVEAGGMQAL
Sbjct: 307 GNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQAL 366

Query: 358 GKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSN 417
           G HLT  S RLVQNCLWTLRNLSD ATKQEG+E +L  LV  L  DD+NV+TCA G LSN
Sbjct: 367 GLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSN 426

Query: 418 LTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVR 477
           LTCNN KNK +V Q  G+EAL+  +LRAGD++DITEPA+CALRHLTSRH EAEMAQN+VR
Sbjct: 427 LTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVR 486

Query: 478 LNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQD 537
           L+YG+P +VKLL+ P+ WPL+KAT+GLIRNLALCPANHAPL+E   IPRLVQLLV+AHQD
Sbjct: 487 LHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD 546

Query: 538 AQRHVA-AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSS 596
            QR  +  GTQQ + +GVRMEEIVEGCTGALHILARD  NR+ I  LNTIPLFVQLLYS 
Sbjct: 547 TQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSP 606

Query: 597 VENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656
           +ENIQRVAAGVLCELAQDKEAA+AI+AEGA+APL ELLHSRNEG ATYAAAVLFR+SEDK
Sbjct: 607 IENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDK 666

Query: 657 NPDYRKRVSVELTNSLFKHDPAAW-EAAQSMIPI---NEPYG-DDMDATYRPMYSSDVPL 711
             DY+KR+SVELT+SLF+ +P AW E A   + I    EP G    D +YR  +S     
Sbjct: 667 PQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQ 726

Query: 712 DPLEMHMDMD---------GDYPIDTYSD 731
           D L M   M+          DYP+D   D
Sbjct: 727 DALGMDPMMEHEMGGHHPGADYPVDGLPD 755


>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
          Length = 1044

 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 111/528 (21%), Positives = 208/528 (39%), Gaps = 52/528 (9%)

Query: 144  LPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM---GSPQLVAAVVRTMQNTS--- 197
            LP +  +L+     +   AA  +  ++K + +RR +    G  +LVA +     +T    
Sbjct: 537  LPIMVNILDSPHKSLKCLAAETIANVAKFKRARRVVRQHGGITKLVALLDCAHDSTKPAQ 596

Query: 198  -------DLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTL 250
                   D++ ARC    L + S       AI K+GGIP L R+L +  E++L   + TL
Sbjct: 597  SSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTL 656

Query: 251  HNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANG 310
                  +E  + A++    ++ +V  LN  N +        +   A  ++E++ ++  +G
Sbjct: 657  QE-CASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCA-EDKETRDLVRLHG 714

Query: 311  GPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQ 370
            G + L  ++ N   ++ L   +  +   S+   N     E   ++ L   LT     ++ 
Sbjct: 715  GLKPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLV 774

Query: 371  NCLWTL------RNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSK 424
            N +  L      R    +  K  G++ ++ +LV       VNV T A G      C    
Sbjct: 775  NVVGALGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNV-TKAVG-----ACAVEP 828

Query: 425  NKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPA 484
               ++        L+ ++L+    D     A      + +     EM ++ V    G+  
Sbjct: 829  ESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVG---GLEL 885

Query: 485  IVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAA 544
            IV LL   N+  ++ +    I N+A    N A + +  V+P L +L    +   + H+A 
Sbjct: 886  IVNLLKSDNK-EVLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLA- 943

Query: 545  GTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVA 604
                        E I   C            NR+       +   V+ L S+  N+ R  
Sbjct: 944  ------------EAISRCCMWG--------RNRVAFGEHKAVAPLVRYLKSNDTNVHRAT 983

Query: 605  AGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRI 652
            A  L +L++D +    +   GA   L++++ S ++     AA  +  I
Sbjct: 984  AQALYQLSEDADNCITMHENGAVKLLLDMVGSPDQDLQEAAAGCISNI 1031



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 113/507 (22%), Positives = 198/507 (39%), Gaps = 60/507 (11%)

Query: 195 NTSDLDTARC---TTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLH 251
           N  + D  +C   +  IL  +SH+ +    I   GG+P +V +L SP +S+   A  T+ 
Sbjct: 501 NLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLAAETIA 560

Query: 252 NLLLYQEGAKMAVRLADGLQKMVPLL----NKNNPKFLAI-------TTDCLQLLAYGNQ 300
           N+  ++  A+  VR   G+ K+V LL    +   P   ++          C  L  +   
Sbjct: 561 NVAKFKR-ARRVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCS 619

Query: 301 ES---KLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL 357
           +S   K  I   GG   L ++++  S+E +L      L+  +   + + AI     ++ L
Sbjct: 620 KSHTNKEAIRKAGGIPLLARLLKT-SHENMLIPVVGTLQECASEENYRAAIKAERIIENL 678

Query: 358 GKHLTSNSPRLVQNCLWTL------RNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCA 411
            K+L S + +L ++C   +      +   D+     GL+ +  +L N    D+   L   
Sbjct: 679 VKNLNSENEQLQEHCAMAIYQCAEDKETRDLVRLHGGLKPLASLLNN---TDNKERLAAV 735

Query: 412 TGTLSNLTCNNSK-NKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAE 470
           TG +    C+ SK N T   +   +E L+   L     +++    V AL           
Sbjct: 736 TGAI--WKCSISKENVTKFREYKAIETLVG--LLTDQPEEVLVNVVGALGECCQERENRV 791

Query: 471 MAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQL 530
           +    VR   GI  +V LL   NQ  LV  T   +   A+ P +   +     +  L  L
Sbjct: 792 I----VRKCGGIQPLVNLLVGINQALLVNVT-KAVGACAVEPESMMIIDRLDGVRLLWSL 846

Query: 531 LVKAHQDAQRHVA------------AGTQ-QPYTDGVRM---------EEIVEGCTGALH 568
           L   H D +   A            AG   + +  G+ +         +E++     A+ 
Sbjct: 847 LKNPHPDVKASAAWALCPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAIT 906

Query: 569 ILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASA 628
            +A+D  N   I     +PL  +L  ++   ++   A  +           A     A A
Sbjct: 907 NIAKDQENLAVITDHGVVPLLSKLANTNNNKLRHHLAEAISRCCMWGRNRVAFGEHKAVA 966

Query: 629 PLMELLHSRNEGTATYAAAVLFRISED 655
           PL+  L S +       A  L+++SED
Sbjct: 967 PLVRYLKSNDTNVHRATAQALYQLSED 993



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 95/470 (20%), Positives = 193/470 (41%), Gaps = 52/470 (11%)

Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
           I  LV+ L    ++    A+ ++ +  L QE  ++A+R   GL+ ++ LL  +  K    
Sbjct: 454 IQKLVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEVKCKIG 513

Query: 288 TTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPA 347
           +   L+ +++ N + +  I+  GG   +V I+ +  ++ L    +  +  ++     +  
Sbjct: 514 SLKILKEISH-NPQIRQNIVDLGGLPIMVNIL-DSPHKSLKCLAAETIANVAKFKRARRV 571

Query: 348 IVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNL-------------SDVATKQEGLESV 392
           + + GG+  L   L    +S +  Q+ L+  R++             S   T +E +   
Sbjct: 572 VRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNKEAIRKA 631

Query: 393 --LKILVNQLSVDDVNVLTCATGTLSNLTCNNSKN-KTLVTQNSGVEALIHAILRAGDKD 449
             + +L   L     N+L    GTL    C + +N +  +     +E L+  +    + +
Sbjct: 632 GGIPLLARLLKTSHENMLIPVVGTLQE--CASEENYRAAIKAERIIENLVKNL--NSENE 687

Query: 450 DITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLA 509
            + E    A+        E +  ++ VRL+ G+  +  LLN  +    + A  G I   +
Sbjct: 688 QLQEHCAMAIYQCA----EDKETRDLVRLHGGLKPLASLLNNTDNKERLAAVTGAIWKCS 743

Query: 510 LCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA------------------AGTQQPYT 551
           +   N    +E   I  LV LL    ++   +V                    G  QP  
Sbjct: 744 ISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQERENRVIVRKCGGIQPLV 803

Query: 552 D---GVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVL 608
           +   G+  + ++   T A+   A +P + M I RL+ + L   LL +   +++  AA  L
Sbjct: 804 NLLVGIN-QALLVNVTKAVGACAVEPESMMIIDRLDGVRLLWSLLKNPHPDVKASAAWAL 862

Query: 609 CELAQD-KEAADAIDA-EGASAPLMELLHSRNEGTATYAAAVLFRISEDK 656
           C   ++ K+A + + +  G    ++ LL S N+       A +  I++D+
Sbjct: 863 CPCIKNAKDAGEMVRSFVGGLELIVNLLKSDNKEVLASVCAAITNIAKDQ 912


>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
          Length = 872

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 105/480 (21%), Positives = 205/480 (42%), Gaps = 48/480 (10%)

Query: 143 ALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTA 202
           A+  LTKLL  ED +V   A MI   L+     ++ L+    ++ +V+  +    ++   
Sbjct: 68  AVEPLTKLLTHEDKIVRRNATMIFGILASNNDVKK-LLRELDVMNSVIAQLAPEEEVVIH 126

Query: 203 RCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLL-YQEGAK 261
              +  L N+S      + IF+ GG+  L+R+LSSP   V   ++  ++NL+  +Q  AK
Sbjct: 127 EFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQCRAK 186

Query: 262 MAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRN 321
           +  +  + +  ++ LL    P    +    L ++A  ++ES+ ++  N G   L++I+  
Sbjct: 187 L--QELNAIPPILDLLKSEYPVIQLLALKTLGVIA-NDKESRTMLRDNQGLDHLIKILET 243

Query: 322 YSYEKLLWTTSRVLKVLSVCPSNKPAIV---EAGGMQALGKHL-TSNSPRLVQNCLWTLR 377
                L       L V++ C  +   +V   + GG++ L      S  P + +N     +
Sbjct: 244 KELNDL---HIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKN---AAK 297

Query: 378 NLSDVATKQEGL-----ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQN 432
            ++  A   E       + V K LV  L  ++      A+  +S + C NS +K     N
Sbjct: 298 AITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAM-CENSGSKDFF-NN 355

Query: 433 SGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQP 492
            G+  LI   L   D +++ E A  AL +LT+ +P      N+     GI  ++ LL+  
Sbjct: 356 QGIPQLIQ--LLKSDNEEVREAAALALANLTTCNP---ANANAAAEADGIDPLINLLSSK 410

Query: 493 NQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA--------- 543
               +  A   ++ N+A+       +Q   ++  ++  L  A+   Q   A         
Sbjct: 411 RDGAIANAAT-VLTNMAMQEPLRLNIQNHDIMHAIISPLRSANTVVQSKAALAVTATACD 469

Query: 544 ---------AGTQQPYTDGVRM--EEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQL 592
                    +G  +P  + +R   +E+ +  + A+ + A D +   E+ RL  + +  ++
Sbjct: 470 VEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGDELTANELCRLGALDILEEV 529



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 81/373 (21%), Positives = 150/373 (40%), Gaps = 42/373 (11%)

Query: 314 ALVQIMRNYSYEKLLWTTSRVL-KVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNC 372
           A V +M N   E++L      + K       NK  ++E G ++ L K LT     + +N 
Sbjct: 28  ATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKIVRRNA 87

Query: 373 LWT---LRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLV 429
                 L + +DV      L+ +  ++      ++V +   A+  L+N++   + +K  +
Sbjct: 88  TMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYT-SKVQI 146

Query: 430 TQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLL 489
            ++ G+E LI  +L + D D       C    +      A++ +    LN  IP I+ LL
Sbjct: 147 FEHGGLEPLIR-LLSSPDPDVKKNSMECIYNLVQDFQCRAKLQE----LN-AIPPILDLL 200

Query: 490 NQPNQWPLVKA----TIGLIRNLALCPANHAPLQEAAVIPRLVQLL-VKAHQDAQRHVAA 544
              +++P+++     T+G+I N      +   L++   +  L+++L  K   D      A
Sbjct: 201 K--SEYPVIQLLALKTLGVIAN---DKESRTMLRDNQGLDHLIKILETKELNDLHIEALA 255

Query: 545 GTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVA 604
                  D   M +I +  TG L  L     N                  S++ +IQ+ A
Sbjct: 256 VIANCLEDMDTMVQIQQ--TGGLKKLLSFAEN------------------STIPDIQKNA 295

Query: 605 AGVLCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISEDK-NPDYRKR 663
           A  + + A D E       +     L+ LL S N+GT   A+  +  + E+  + D+   
Sbjct: 296 AKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENSGSKDFFNN 355

Query: 664 VSVELTNSLFKHD 676
             +     L K D
Sbjct: 356 QGIPQLIQLLKSD 368


>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
          Length = 1363

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 76/336 (22%), Positives = 148/336 (44%), Gaps = 23/336 (6%)

Query: 203 RCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKM 262
           +CT  +L   S   + +  +F  G   A  R       +++  ++ T H  +L +   K+
Sbjct: 568 QCTPLLLAATSGALDTIQYLFSIG---ANWRKTDIKGNNIIHLSVLTFHTEVL-KYIIKL 623

Query: 263 AVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY 322
            +      + +V +L   + K   +    L+++   N +    IL  G   AL+ ++++ 
Sbjct: 624 NIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKS- 682

Query: 323 SYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-- 380
           S  KL   T  +L  +S   S   A+VEAGG+ +L   L  + P +   C   L +++  
Sbjct: 683 SKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC 742

Query: 381 ---DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEA 437
              DV  K  G+ S    L+N L+++  NVL      +  L   N  N+  V ++ G+  
Sbjct: 743 ENKDVIAKYNGIPS----LINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY 798

Query: 438 LIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPL 497
           LI  +  + D D +   +  A+  +   + E    Q+++ +   IP +V L         
Sbjct: 799 LIRFL--SSDSDVLKAVSSAAIAEVGRDNKE---IQDAIAMEGAIPPLVALFKGKQISVQ 853

Query: 498 VKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVK 533
           +K  +  + +LA   +++A +Q+A +   L + L+K
Sbjct: 854 MKGAMA-VESLA---SHNALIQKAFLEKSLTKYLLK 885



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 61/291 (20%), Positives = 125/291 (42%), Gaps = 16/291 (5%)

Query: 205 TTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAV 264
           T  +L N+S H+  + A+ ++GGIP+L+ +L      V       L+++   +   K  +
Sbjct: 691 TVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCEN--KDVI 748

Query: 265 RLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSY 324
              +G+  ++ LLN N    L    +C+++L  GN+ ++  +  + G   L++ + + S 
Sbjct: 749 AKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSD 808

Query: 325 EKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL-----GKHLTSNSPRLVQNCLWTLRNL 379
                +++ + +V       + AI   G +  L     GK ++      +   + +L + 
Sbjct: 809 VLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM--AVESLASH 866

Query: 380 SDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI 439
           + +  K    +S+ K L+  L    ++V       L  L     K +  + +  G   +I
Sbjct: 867 NALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIGYSFII 926

Query: 440 HAILRAGDK-DDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLL 489
           + +L    K   +   AV AL        ++ M QN +    GI  +V+LL
Sbjct: 927 NMLLSPSAKMQYVGGEAVIAL------SKDSRMHQNQICEGNGIAPLVRLL 971



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 42/180 (23%), Positives = 83/180 (46%), Gaps = 9/180 (5%)

Query: 144 LPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM---GSPQLVAAVVRTMQNTSDLD 200
           +P L  LL      +  K   +++ +S  +++  AL+   G P L+  +V          
Sbjct: 673 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVH--- 729

Query: 201 TARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGA 260
            +RC   IL++++   E    I K  GIP+L+ +L+  +E+VL   +  +  L +  E  
Sbjct: 730 -SRCAV-ILYDIAQC-ENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENN 786

Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
           + AVR   GL  ++  L+ ++    A+++  +  +   N+E +  I   G    LV + +
Sbjct: 787 QRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFK 846



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 43/177 (24%), Positives = 74/177 (41%), Gaps = 22/177 (12%)

Query: 482 IPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRH 541
           IPA++ LL   ++  L   T+GL+ N++   +    L EA  IP L+ LLV    +    
Sbjct: 673 IPALINLLKS-SKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSR 731

Query: 542 VAAG----TQQPYTD---------------GVRMEEIVEGCTGALHILARDPMNRMEIFR 582
            A       Q    D                + +E ++      + +L     N     R
Sbjct: 732 CAVILYDIAQCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVR 791

Query: 583 LNT-IPLFVQLLYSSVENIQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR 637
            +  +P  ++ L S  + ++ V++  + E+ +D KE  DAI  EGA  PL+ L   +
Sbjct: 792 EHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGK 848



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 23/80 (28%), Positives = 36/80 (45%)

Query: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNE 639
           I    TIP  + LL SS   +Q    G+L  ++  K A  A+   G    L+ LL     
Sbjct: 667 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEP 726

Query: 640 GTATYAAAVLFRISEDKNPD 659
              +  A +L+ I++ +N D
Sbjct: 727 EVHSRCAVILYDIAQCENKD 746


>gi|32526896 armadillo repeat containing 8 isoform 2 [Homo sapiens]
          Length = 659

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 45/207 (21%), Positives = 92/207 (44%), Gaps = 5/207 (2%)

Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
           K  +   + + ++V  L++++ K       CL  L+   Q+ +     +   + L+++++
Sbjct: 363 KKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQ 422

Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380
           N   E L+  +S +  +L     +K  I+E+G ++ L     S +P L  N +W L N++
Sbjct: 423 NAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMA 482

Query: 381 DVATKQEGLESVLKILVNQ----LSVDDVNVLTCATGTLSNLTCNNSK-NKTLVTQNSGV 435
             A ++   + +  +   Q    LS  D+NVL    G L NL       +K + T    +
Sbjct: 483 FQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQI 542

Query: 436 EALIHAILRAGDKDDITEPAVCALRHL 462
              +  IL      ++ E  +C L ++
Sbjct: 543 MQAVTLILEGEHNIEVKEQTLCILANI 569



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 78/376 (20%), Positives = 160/376 (42%), Gaps = 36/376 (9%)

Query: 101 LLATQVEGQATNLQRLAEPS---QLLKSAIVHLINYQDDA---ELATRALPELTKLLNDE 154
           LL  +VEG  T L  L EP    Q + S   HLI    D      +  A+ ++ +L +D 
Sbjct: 279 LLEERVEGAET-LAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDL 337

Query: 155 DPVVVTKAA---MIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTS---DLDTARCTTSI 208
                 + A   +  +  +  E  R+ ++ +  ++  +V  +  +S    L   RC    
Sbjct: 338 KHAHELRQAAFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRC---- 393

Query: 209 LHNLSHHREGLLAIFKSGGI-PALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267
           LH+LS   + L   F+   +   L+++L +  + +L  A + L NLLL    +K  +  +
Sbjct: 394 LHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILES 453

Query: 268 DGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQALVQIMRNYSYEK 326
             ++ +  L    NP         L  +A+   Q+ K  IL +   + L +++ +     
Sbjct: 454 GAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNV 513

Query: 327 LLWTTSRVLKVLSVCP-------SNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNL 379
           L+ T   +  +LS  P       ++   I++A  +   G+H    +  + +  L  L N+
Sbjct: 514 LMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEH----NIEVKEQTLCILANI 569

Query: 380 SDVATKQEGL---ESVLKILVNQLSVDDVNVLTCATGTLSNLTCN---NSKNKTLVTQNS 433
           +D  T ++ +   + +L+ +   +    V +   A   +SNL  N    S+ +    ++ 
Sbjct: 570 ADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDM 629

Query: 434 GVEALIHAILRAGDKD 449
           G+  ++H + ++ D +
Sbjct: 630 GIVDILHKLSQSPDSN 645


>gi|11034811 catenin (cadherin-associated protein), delta 2 (neural
           plakophilin-related arm-repeat protein) [Homo sapiens]
          Length = 1225

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 61/245 (24%), Positives = 103/245 (42%), Gaps = 29/245 (11%)

Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
           +P +++ML     SV   A   L +L       K  +R   G+Q +V LL+    +    
Sbjct: 552 LPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRS 611

Query: 288 TTDCLQLLAYG--NQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK 345
               L+ L YG  N ++K+ +   GG  ALV+++R  +  ++    + VL  LS C + K
Sbjct: 612 ACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALK 671

Query: 346 PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDV 405
             I                    +Q+ L  L N   V     G E+       ++ +   
Sbjct: 672 MPI--------------------IQDALAVLTNA--VIIPHSGWENSPLQDDRKIQLHSS 709

Query: 406 NVLTCATGTLSNLTCNNSKNKTLVTQNSGV-EALIHAILRAGDKDDI----TEPAVCALR 460
            VL  ATG L N++    + +  + +  G+ +AL++ I  A    +I     E  VC LR
Sbjct: 710 QVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGSSEIDSKTVENCVCILR 769

Query: 461 HLTSR 465
           +L+ R
Sbjct: 770 NLSYR 774



 Score = 37.0 bits (84), Expect = 0.067
 Identities = 93/412 (22%), Positives = 158/412 (38%), Gaps = 87/412 (21%)

Query: 144 LPELTKLLNDEDPVVVTKAAMIVNQL----SKKEASRRALMGSPQLVAAVVRTMQNTSDL 199
           LPE+ ++L  + P V + AA  +  L    +K +A  R   G   LV  +   M      
Sbjct: 552 LPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMT----- 606

Query: 200 DTARCTTSILHNLSHHR---EGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLY 256
           +  R     L NL + +   +  +A+   GGIPALVR+L    +  +   +T        
Sbjct: 607 EVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDLEIRELVT-------- 658

Query: 257 QEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALV 316
             G    +   D L+  +P++       LA+ T+ + +   G + S L           +
Sbjct: 659 --GVLWNLSSCDALK--MPIIQ----DALAVLTNAVIIPHSGWENSPL------QDDRKI 704

Query: 317 QIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGM---------QALGKHLTSNSPR 367
           Q+   +S + L   T  +  V S     +  + E  G+          ALG   +    +
Sbjct: 705 QL---HSSQVLRNATGCLRNVSSAGEEARRRMRECDGLTDALLYVIQSALGS--SEIDSK 759

Query: 368 LVQNCLWTLRNLSD--VATKQEGLESVLKILVNQLSVDDVNVLTCATGT---LSNLTCNN 422
            V+NC+  LRNLS    A   +G           +  D+++ L C         +  C  
Sbjct: 760 TVENCVCILRNLSYRLAAETSQG---------QHMGTDELDGLLCGEANGKDAESSGCWG 810

Query: 423 SKNKTLVTQN---------------SGVEALIH--------AILRAGDKDDITEPAVCAL 459
            K K   +Q+                G++ L H         +L      D  E A  AL
Sbjct: 811 KKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGAL 870

Query: 460 RHLTSRHPE-AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLAL 510
           ++L +   + +   + +VR   G+P +V+LL   N   +V A    +RN+AL
Sbjct: 871 QNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDND-RVVCAVATALRNMAL 921



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 33/137 (24%), Positives = 64/137 (46%), Gaps = 11/137 (8%)

Query: 389 LESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDK 448
           L  V+++L +Q      +V + A   L +L   ++K K  + +  G++ L+  +      
Sbjct: 552 LPEVIQMLQHQFP----SVQSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHR--M 605

Query: 449 DDITEPAVCALRHLTSRHPEAEMAQNSVRLNY--GIPAIVKLLNQPNQWPLVKATIGLIR 506
            ++   A  ALR+L       +   N + L    GIPA+V+LL +     + +   G++ 
Sbjct: 606 TEVHRSACGALRNLVYGKANDD---NKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLW 662

Query: 507 NLALCPANHAPLQEAAV 523
           NL+ C A   P+ + A+
Sbjct: 663 NLSSCDALKMPIIQDAL 679


>gi|4504897 karyopherin alpha 2 [Homo sapiens]
          Length = 529

 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 94/481 (19%), Positives = 186/481 (38%), Gaps = 79/481 (16%)

Query: 95  GEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAE--LATRALPELTKLLN 152
           G+DS+ +   ++E     L++  +  Q+LK   V   ++ DDA   L      + T   +
Sbjct: 21  GKDSTEMRRRRIEVNV-ELRKAKKDDQMLKRRNVS--SFPDDATSPLQENRNNQGTVNWS 77

Query: 153 DEDPVVVTKAAMIVNQLSKKEASRRALMGS--------------PQLVAAVVRTMQNTSD 198
            +D V    ++ + NQL   +A+R+ L                 P+ V+ + RT  +   
Sbjct: 78  VDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQ 137

Query: 199 LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNL----- 253
            ++A   T+I    S   +   A+   G IPA + +L+SP   +   A+  L N+     
Sbjct: 138 FESAWALTNIASGTSEQTK---AVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGS 194

Query: 254 ----LLYQEGA----------------------------------KMAVRLADGLQKMVP 275
               L+ + GA                                  K      D +++++P
Sbjct: 195 VFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILP 254

Query: 276 ----LLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTT 331
               LL+ ++P+ LA T   +  L  G  E   +++  G    LV+++       +    
Sbjct: 255 TLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPAL 314

Query: 332 SRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLES 391
             +  +++        +++AG +      LT+    + +   WT+ N++  A +Q+ ++ 
Sbjct: 315 RAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT--AGRQDQIQQ 372

Query: 392 VLK-----ILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAG 446
           V+       LV+ LS  D      A   ++N T   +  + +   + G+   +  +L A 
Sbjct: 373 VVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAK 432

Query: 447 DKDDITE--PAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGL 504
           D   I     A+  +     +  E E     +    G+  I  L N  N+  + KA++ L
Sbjct: 433 DTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENE-SVYKASLSL 491

Query: 505 I 505
           I
Sbjct: 492 I 492



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 44/176 (25%), Positives = 77/176 (43%), Gaps = 26/176 (14%)

Query: 347 AIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-------DVATKQEGLESVLKILVNQ 399
           A+V+ G + A    L S    + +  +W L N++       D+  K   ++ +L +    
Sbjct: 157 AVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLAL---- 212

Query: 400 LSVDDVNVLTCATGTLSNLT---CNNSKNKTLVTQNSGVEALIHAILRAGDKDD--ITEP 454
           L+V D++ L C  G L NLT    N  +NK        VE ++  ++R    DD  +   
Sbjct: 213 LAVPDMSSLAC--GYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLAD 270

Query: 455 AVCALRHLTSRHPE--AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNL 508
              A+ +LT    E    + +  V     +P +VKLL   ++ P+V   +  I N+
Sbjct: 271 TCWAISYLTDGPNERIGMVVKTGV-----VPQLVKLLG-ASELPIVTPALRAIGNI 320


>gi|4502247 armadillo repeat protein [Homo sapiens]
          Length = 962

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 60/242 (24%), Positives = 103/242 (42%), Gaps = 28/242 (11%)

Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
           +P ++ ML  PV+ V   A   L +L    EG K  VR   GL  +V LL+    +    
Sbjct: 360 LPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRR 419

Query: 288 TTDCLQLLAYG-NQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKP 346
               L+ L+YG + ++K  I   GG  ALV+++R     ++    +  L  LS     K 
Sbjct: 420 ACGALRNLSYGRDTDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSYEPLKM 479

Query: 347 AIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVN 406
            I++  G+Q L   +      +V +  W      D   +     +V K            
Sbjct: 480 VIID-HGLQTLTHEV------IVPHSGWEREPNEDSKPRDAEWTTVFK------------ 520

Query: 407 VLTCATGTLSNLTCNNSKNKTLVTQNSG-VEALIHAILRAGDKDDI----TEPAVCALRH 461
                +G L N++ + ++ +  + +  G V+AL+HA+  A  + D      E  VC +R+
Sbjct: 521 ---NTSGCLRNVSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRN 577

Query: 462 LT 463
           L+
Sbjct: 578 LS 579



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 54/179 (30%), Positives = 79/179 (44%), Gaps = 21/179 (11%)

Query: 102 LATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDE-DPVVVT 160
           LA    G   +L RL   S  + SA       + +       LPE+  +L    DPV   
Sbjct: 325 LAQPERGSMGSLDRLVRRSPSVDSA-------RKEPRWRDPELPEVLAMLRHPVDPVKAN 377

Query: 161 KAAMIVNQLSKKEASRRA---LMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHRE 217
            AA + +   + E  +R    L G P LVA +     +    +  R     L NLS+ R+
Sbjct: 378 AAAYLQHLCFENEGVKRRVRQLRGLPLLVALL-----DHPRAEVRRRACGALRNLSYGRD 432

Query: 218 --GLLAIFKSGGIPALVRMLSSPVESVLFYAIT-TLHNLLLYQEGAKMAVRLADGLQKM 273
                AI   GG+PALVR+L +  ++ +   +T TL NL  Y E  KM + +  GLQ +
Sbjct: 433 TDNKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLWNLSSY-EPLKMVI-IDHGLQTL 489


>gi|53829376 plakophilin 4 isoform b [Homo sapiens]
          Length = 1149

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 82/353 (23%), Positives = 137/353 (38%), Gaps = 53/353 (15%)

Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
           +P ++ ML     SV   A   L +L       KM V    G++ +V LL+    +    
Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589

Query: 288 TTDCLQLLAYGNQ--ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK 345
               L+ L +G    E+K+ +   GG  AL++++R     ++    + VL  LS C + K
Sbjct: 590 ACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVK 649

Query: 346 PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDV 405
             I+      AL    T  +  +V +  W   +  D                +++     
Sbjct: 650 MTIIR----DALS---TLTNTVIVPHSGWNNSSFDD---------------DHKIKFQTS 687

Query: 406 NVLTCATGTLSNLTCNNSKNKTLVTQNSG-VEAL---IHAILRAGDKDDIT-EPAVCALR 460
            VL   TG L NL+    + +  +    G V++L   IH  +   D D  T E  VC LR
Sbjct: 688 LVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLR 747

Query: 461 HLTSRHPEAEMAQNSVRLNYGIPAIVKLL--------NQPNQWPLVKAT----------- 501
           +L+ R    E+     RL  G+  +  LL        ++P+ W   K             
Sbjct: 748 NLSYR---LELEVPQARL-LGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWD 803

Query: 502 -IGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDG 553
            +G I  L+  P     L   +V+   + LL ++   A    +AG+ Q  + G
Sbjct: 804 GVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAG 856



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 103/438 (23%), Positives = 164/438 (37%), Gaps = 115/438 (26%)

Query: 134 QDDAELATR--ALPELTKLLNDEDPVVVTKAAMIVNQLS------KKEASRRALMGSPQL 185
           +D  E A R   LPE+  +L  + P V   AA  +  L       K E  R  L G   L
Sbjct: 518 KDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCR--LGGIKHL 575

Query: 186 VAAVVRTMQNTSDLDTARCTTSILHNLSHHR---EGLLAIFKSGGIPALVRMLSSPVESV 242
           V  +   +     L+  +     L NL   +   E  +A+   GGIPAL+R+L   +++ 
Sbjct: 576 VDLLDHRV-----LEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAE 630

Query: 243 LFYAITTLHNLLLYQEGAKMAVRLADGLQKM-----VPLLNKNNPKF------------- 284
           +   +T +   L   +  KM + + D L  +     VP    NN  F             
Sbjct: 631 VRELVTGVLWNLSSCDAVKMTI-IRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLV 689

Query: 285 LAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSN 344
           L  TT CL+ L+   +E++             + MR  S E L+     +L V+  C + 
Sbjct: 690 LRNTTGCLRNLSSAGEEAR-------------KQMR--SCEGLV---DSLLYVIHTCVNT 731

Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDD 404
                            +    + V+NC+ TLRNLS            L++ V Q  +  
Sbjct: 732 -----------------SDYDSKTVENCVCTLRNLS----------YRLELEVPQARLLG 764

Query: 405 VNVLTCATGTL-----SNLTCNNSKNKT------------------LVTQNSGVEALIH- 440
           +N L    G       S  +C   K K                   L     GVE L H 
Sbjct: 765 LNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHP 824

Query: 441 -------AILRAGDKDDITEPAVCALRHLTSRHPE-AEMAQNSVRLNYGIPAIVKLLNQP 492
                   +L         E +  +L++L++ + + A   + +VR   G+P +V+LL   
Sbjct: 825 SVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMD 884

Query: 493 NQWPLVKATIGLIRNLAL 510
           N   +V +    +RN+AL
Sbjct: 885 ND-RVVSSVATALRNMAL 901



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 28/117 (23%), Positives = 56/117 (47%), Gaps = 13/117 (11%)

Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-DVATKQEGLESVLKILVNQL--- 400
           + A+ +  G+  L + L  ++ R+V +    LRN++ DV  K+   +  ++ LVN+L   
Sbjct: 865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGG 924

Query: 401 ------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDI 451
                 S + +  + CA   L  +T  N +N   +  + G+E L++     GD+  +
Sbjct: 925 NGPSVLSDETMAAICCA---LHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSL 978



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 19/139 (13%)

Query: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI- 439
           + A +   L  V+ +L +Q      N    A   L +L   ++K K  V +  G++ L+ 
Sbjct: 522 EFAWRDPELPEVIHMLQHQFPSVQAN----AAAYLQHLCFGDNKVKMEVCRLGGIKHLVD 577

Query: 440 ---HAILRAGDKDDITEPAVCALRHLT--SRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQ 494
              H +L      ++ + A  ALR+L       E ++A  +V    GIPA+++LL +   
Sbjct: 578 LLDHRVL------EVQKNACGALRNLVFGKSTDENKIAMKNVG---GIPALLRLLRKSID 628

Query: 495 WPLVKATIGLIRNLALCPA 513
             + +   G++ NL+ C A
Sbjct: 629 AEVRELVTGVLWNLSSCDA 647


>gi|53829374 plakophilin 4 isoform a [Homo sapiens]
          Length = 1192

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 82/353 (23%), Positives = 137/353 (38%), Gaps = 53/353 (15%)

Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
           +P ++ ML     SV   A   L +L       KM V    G++ +V LL+    +    
Sbjct: 530 LPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCRLGGIKHLVDLLDHRVLEVQKN 589

Query: 288 TTDCLQLLAYGNQ--ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNK 345
               L+ L +G    E+K+ +   GG  AL++++R     ++    + VL  LS C + K
Sbjct: 590 ACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEVRELVTGVLWNLSSCDAVK 649

Query: 346 PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDV 405
             I+      AL    T  +  +V +  W   +  D                +++     
Sbjct: 650 MTIIR----DALS---TLTNTVIVPHSGWNNSSFDD---------------DHKIKFQTS 687

Query: 406 NVLTCATGTLSNLTCNNSKNKTLVTQNSG-VEAL---IHAILRAGDKDDIT-EPAVCALR 460
            VL   TG L NL+    + +  +    G V++L   IH  +   D D  T E  VC LR
Sbjct: 688 LVLRNTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLR 747

Query: 461 HLTSRHPEAEMAQNSVRLNYGIPAIVKLL--------NQPNQWPLVKAT----------- 501
           +L+ R    E+     RL  G+  +  LL        ++P+ W   K             
Sbjct: 748 NLSYR---LELEVPQARL-LGLNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWD 803

Query: 502 -IGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDG 553
            +G I  L+  P     L   +V+   + LL ++   A    +AG+ Q  + G
Sbjct: 804 GVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAG 856



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 103/438 (23%), Positives = 164/438 (37%), Gaps = 115/438 (26%)

Query: 134 QDDAELATR--ALPELTKLLNDEDPVVVTKAAMIVNQLS------KKEASRRALMGSPQL 185
           +D  E A R   LPE+  +L  + P V   AA  +  L       K E  R  L G   L
Sbjct: 518 KDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEVCR--LGGIKHL 575

Query: 186 VAAVVRTMQNTSDLDTARCTTSILHNLSHHR---EGLLAIFKSGGIPALVRMLSSPVESV 242
           V  +   +     L+  +     L NL   +   E  +A+   GGIPAL+R+L   +++ 
Sbjct: 576 VDLLDHRV-----LEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAE 630

Query: 243 LFYAITTLHNLLLYQEGAKMAVRLADGLQKM-----VPLLNKNNPKF------------- 284
           +   +T +   L   +  KM + + D L  +     VP    NN  F             
Sbjct: 631 VRELVTGVLWNLSSCDAVKMTI-IRDALSTLTNTVIVPHSGWNNSSFDDDHKIKFQTSLV 689

Query: 285 LAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSN 344
           L  TT CL+ L+   +E++             + MR  S E L+     +L V+  C + 
Sbjct: 690 LRNTTGCLRNLSSAGEEAR-------------KQMR--SCEGLV---DSLLYVIHTCVNT 731

Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDD 404
                            +    + V+NC+ TLRNLS            L++ V Q  +  
Sbjct: 732 -----------------SDYDSKTVENCVCTLRNLS----------YRLELEVPQARLLG 764

Query: 405 VNVLTCATGTL-----SNLTCNNSKNKT------------------LVTQNSGVEALIH- 440
           +N L    G       S  +C   K K                   L     GVE L H 
Sbjct: 765 LNELDDLLGKESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHP 824

Query: 441 -------AILRAGDKDDITEPAVCALRHLTSRHPE-AEMAQNSVRLNYGIPAIVKLLNQP 492
                   +L         E +  +L++L++ + + A   + +VR   G+P +V+LL   
Sbjct: 825 SVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMD 884

Query: 493 NQWPLVKATIGLIRNLAL 510
           N   +V +    +RN+AL
Sbjct: 885 ND-RVVSSVATALRNMAL 901



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 28/117 (23%), Positives = 56/117 (47%), Gaps = 13/117 (11%)

Query: 345 KPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-DVATKQEGLESVLKILVNQL--- 400
           + A+ +  G+  L + L  ++ R+V +    LRN++ DV  K+   +  ++ LVN+L   
Sbjct: 865 RAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGG 924

Query: 401 ------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDI 451
                 S + +  + CA   L  +T  N +N   +  + G+E L++     GD+  +
Sbjct: 925 NGPSVLSDETMAAICCA---LHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSL 978



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 35/139 (25%), Positives = 64/139 (46%), Gaps = 19/139 (13%)

Query: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI- 439
           + A +   L  V+ +L +Q      N    A   L +L   ++K K  V +  G++ L+ 
Sbjct: 522 EFAWRDPELPEVIHMLQHQFPSVQAN----AAAYLQHLCFGDNKVKMEVCRLGGIKHLVD 577

Query: 440 ---HAILRAGDKDDITEPAVCALRHLT--SRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQ 494
              H +L      ++ + A  ALR+L       E ++A  +V    GIPA+++LL +   
Sbjct: 578 LLDHRVL------EVQKNACGALRNLVFGKSTDENKIAMKNVG---GIPALLRLLRKSID 628

Query: 495 WPLVKATIGLIRNLALCPA 513
             + +   G++ NL+ C A
Sbjct: 629 AEVRELVTGVLWNLSSCDA 647


>gi|53729344 plakophilin 1 isoform 1a [Homo sapiens]
          Length = 726

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 97/471 (20%), Positives = 176/471 (37%), Gaps = 62/471 (13%)

Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267
           I H           +++ GGI  LV +L SP ++V   A   L NL+      K+  R  
Sbjct: 269 IQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ 328

Query: 268 DGLQKMVPLLNK-NNPKFLAITTDCLQLLAYGNQ-------------ESKLIILANGGPQ 313
           +G+++ V LL +  N +     T  L  L+  ++               ++II  +G   
Sbjct: 329 NGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCD 388

Query: 314 ALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGG----MQALGKHLTSNS---P 366
               + R     ++ +  +  L+ LS   + +  +    G    + A  ++  + S    
Sbjct: 389 GNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDD 448

Query: 367 RLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLT--CATGTLSNLT---CN 421
           + V+NC+  L NLS        L++ +     QL  +  N  T   +TG  SN +    N
Sbjct: 449 KSVENCMCVLHNLS------YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMN 502

Query: 422 NSKNKTL---VTQNSGVEALIHA--------ILRAGDKDDITEPAVCALRHLTSRH--PE 468
           N+ +  L    T   G   L H+        ++    KD   E    AL++LT+      
Sbjct: 503 NNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMS 562

Query: 469 AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLV 528
           + M+Q       G+P I +LL   N   +V++   L+ N++  P  H  +    V P + 
Sbjct: 563 SGMSQLIGLKEKGLPQIARLLQSGNS-DVVRSGASLLSNMSRHPLLHRVMGN-QVFPEVT 620

Query: 529 QLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPL 588
           +LL              T          + +   C    +++A  P    + F  + +  
Sbjct: 621 RLL--------------TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNN 666

Query: 589 FVQLLYSSVE-NIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRN 638
            + L  SS        A  +L ++   KE    +  +G    ++  L   N
Sbjct: 667 IINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGAN 717



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 86/415 (20%), Positives = 148/415 (35%), Gaps = 87/415 (20%)

Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
           IP  V+ LSS  E         + +     E AK  V    G+ K+V LL   N      
Sbjct: 247 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQA 306

Query: 288 TTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPA 347
               L+ L + +  +KL      G +  V ++R                           
Sbjct: 307 AAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRT------------------------- 341

Query: 348 IVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQL------- 400
                G   + K LT          LW L +  ++  K+E +   L +L +++       
Sbjct: 342 -----GNAEIQKQLTG--------LLWNLSSTDEL--KEELIADALPVLADRVIIPFSGW 386

Query: 401 ---------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI----HAILRAGD 447
                     V D  V   ATG L NL+  ++  +T+   +  +++L+    + +  +  
Sbjct: 387 CDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRC 446

Query: 448 KDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRN 507
            D   E  +C L +L+ R  +AE+     +L Y         N  N +   K++ G   N
Sbjct: 447 DDKSVENCMCVLHNLSYR-LDAEVPTRYRQLEY---------NARNAY-TEKSSTGCFSN 495

Query: 508 LALCPANH---APLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCT 564
            +    N+    PL E    P+    L   H DA R     T        + +  +E C 
Sbjct: 496 KSDKMMNNNYDCPLPEEETNPKGSGWLY--HSDAIR-----TYLNLMGKSKKDATLEACA 548

Query: 565 GALHILARDP------MNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQ 613
           GAL  L          M+++   +   +P   +LL S   ++ R  A +L  +++
Sbjct: 549 GALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 603


>gi|169218113 PREDICTED: similar to plakophilin 1, partial [Homo
           sapiens]
          Length = 625

 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 97/471 (20%), Positives = 176/471 (37%), Gaps = 62/471 (13%)

Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267
           I H           +++ GGI  LV +L SP ++V   A   L NL+      K+  R  
Sbjct: 168 IQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQ 227

Query: 268 DGLQKMVPLLNK-NNPKFLAITTDCLQLLAYGNQ-------------ESKLIILANGGPQ 313
           +G+++ V LL +  N +     T  L  L+  ++               ++II  +G   
Sbjct: 228 NGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDELKEELIADALPVLADRVIIPFSGWCD 287

Query: 314 ALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGG----MQALGKHLTSNS---P 366
               + R     ++ +  +  L+ LS   + +  +    G    + A  ++  + S    
Sbjct: 288 GNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDD 347

Query: 367 RLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLT--CATGTLSNLT---CN 421
           + V+NC+  L NLS        L++ +     QL  +  N  T   +TG  SN +    N
Sbjct: 348 KSVENCMCVLHNLS------YRLDAEVPTRYRQLEYNARNAYTEKSSTGCFSNKSDKMMN 401

Query: 422 NSKNKTL---VTQNSGVEALIHA--------ILRAGDKDDITEPAVCALRHLTSRH--PE 468
           N+ +  L    T   G   L H+        ++    KD   E    AL++LT+      
Sbjct: 402 NNYDCPLPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMS 461

Query: 469 AEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLV 528
           + M+Q       G+P I +LL   N   +V++   L+ N++  P  H  +    V P + 
Sbjct: 462 SGMSQLIGLKEKGLPQIARLLQSGNS-DVVRSGASLLSNMSRHPLLHRVMGN-QVFPEVT 519

Query: 529 QLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPL 588
           +LL              T          + +   C    +++A  P    + F  + +  
Sbjct: 520 RLL--------------TSHTGNTSNSEDILSSACYTVRNLMASQPQLAKQYFSSSMLNN 565

Query: 589 FVQLLYSSVE-NIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRN 638
            + L  SS        A  +L ++   KE    +  +G    ++  L   N
Sbjct: 566 IINLCRSSASPKAAEAARLLLSDMWSSKELQGVLRQQGFDRNMLGTLAGAN 616



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 86/415 (20%), Positives = 148/415 (35%), Gaps = 87/415 (20%)

Query: 228 IPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAI 287
           IP  V+ LSS  E         + +     E AK  V    G+ K+V LL   N      
Sbjct: 146 IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSPNQNVQQA 205

Query: 288 TTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPA 347
               L+ L + +  +KL      G +  V ++R                           
Sbjct: 206 AAGALRNLVFRSTTNKLETRRQNGIREAVSLLRRT------------------------- 240

Query: 348 IVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQL------- 400
                G   + K LT          LW L +  ++  K+E +   L +L +++       
Sbjct: 241 -----GNAEIQKQLTG--------LLWNLSSTDEL--KEELIADALPVLADRVIIPFSGW 285

Query: 401 ---------SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI----HAILRAGD 447
                     V D  V   ATG L NL+  ++  +T+   +  +++L+    + +  +  
Sbjct: 286 CDGNSNMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRC 345

Query: 448 KDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRN 507
            D   E  +C L +L+ R  +AE+     +L Y         N  N +   K++ G   N
Sbjct: 346 DDKSVENCMCVLHNLSYR-LDAEVPTRYRQLEY---------NARNAY-TEKSSTGCFSN 394

Query: 508 LALCPANH---APLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCT 564
            +    N+    PL E    P+    L   H DA R     T        + +  +E C 
Sbjct: 395 KSDKMMNNNYDCPLPEEETNPKGSGWLY--HSDAIR-----TYLNLMGKSKKDATLEACA 447

Query: 565 GALHILARDP------MNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQ 613
           GAL  L          M+++   +   +P   +LL S   ++ R  A +L  +++
Sbjct: 448 GALQNLTASKGLMSSGMSQLIGLKEKGLPQIARLLQSGNSDVVRSGASLLSNMSR 502


>gi|29540566 armadillo repeat containing, X-linked 3 [Homo sapiens]
          Length = 379

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 42/169 (24%), Positives = 72/169 (42%), Gaps = 13/169 (7%)

Query: 80  ARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLIN-----YQ 134
           ARA R R A+    S      +L+ Q   +   L  ++E   +L++A++ L N     + 
Sbjct: 96  ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155

Query: 135 DDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLS-KKEASRRALMGSPQLVAAVVRTM 193
            D       LP + K+LN  DP+V  KA +++N LS   E  RR  +   Q+    + + 
Sbjct: 156 RDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSR 215

Query: 194 QNTSD-------LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRML 235
            N+S        L     T    H L++       +F +G     +++L
Sbjct: 216 LNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVL 264



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 10/104 (9%)

Query: 344 NKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVD 403
           N+  I + GG+  + K L +  P + +  L  L NLS  A  Q      LK+ +NQ+  D
Sbjct: 155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRR----LKVYMNQVCDD 210

Query: 404 DV------NVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHA 441
            +      +V       L+N+T  N     L    S    L  A
Sbjct: 211 TITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSA 254


>gi|29540564 armadillo repeat containing, X-linked 3 [Homo sapiens]
          Length = 379

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 42/169 (24%), Positives = 72/169 (42%), Gaps = 13/169 (7%)

Query: 80  ARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLIN-----YQ 134
           ARA R R A+    S      +L+ Q   +   L  ++E   +L++A++ L N     + 
Sbjct: 96  ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155

Query: 135 DDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLS-KKEASRRALMGSPQLVAAVVRTM 193
            D       LP + K+LN  DP+V  KA +++N LS   E  RR  +   Q+    + + 
Sbjct: 156 RDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSR 215

Query: 194 QNTSD-------LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRML 235
            N+S        L     T    H L++       +F +G     +++L
Sbjct: 216 LNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVL 264



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 10/104 (9%)

Query: 344 NKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVD 403
           N+  I + GG+  + K L +  P + +  L  L NLS  A  Q      LK+ +NQ+  D
Sbjct: 155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRR----LKVYMNQVCDD 210

Query: 404 DV------NVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHA 441
            +      +V       L+N+T  N     L    S    L  A
Sbjct: 211 TITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSA 254


>gi|7705274 armadillo repeat containing, X-linked 3 [Homo sapiens]
          Length = 379

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 42/169 (24%), Positives = 72/169 (42%), Gaps = 13/169 (7%)

Query: 80  ARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLIN-----YQ 134
           ARA R R A+    S      +L+ Q   +   L  ++E   +L++A++ L N     + 
Sbjct: 96  ARATRARRAVQKRASPNSDDTVLSPQELQKVLCLVEMSEKPYILEAALIALGNNAAYAFN 155

Query: 135 DDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLS-KKEASRRALMGSPQLVAAVVRTM 193
            D       LP + K+LN  DP+V  KA +++N LS   E  RR  +   Q+    + + 
Sbjct: 156 RDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRRLKVYMNQVCDDTITSR 215

Query: 194 QNTSD-------LDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRML 235
            N+S        L     T    H L++       +F +G     +++L
Sbjct: 216 LNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSAGNEETKLQVL 264



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 28/104 (26%), Positives = 42/104 (40%), Gaps = 10/104 (9%)

Query: 344 NKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSVD 403
           N+  I + GG+  + K L +  P + +  L  L NLS  A  Q      LK+ +NQ+  D
Sbjct: 155 NRDIIRDLGGLPIVAKILNTRDPIVKEKALIVLNNLSVNAENQRR----LKVYMNQVCDD 210

Query: 404 DV------NVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHA 441
            +      +V       L+N+T  N     L    S    L  A
Sbjct: 211 TITSRLNSSVQLAGLRLLTNMTVTNEYQHMLANSISDFFRLFSA 254


>gi|5031587 adenomatosis polyposis coli 2 [Homo sapiens]
          Length = 2303

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 82/339 (24%), Positives = 143/339 (42%), Gaps = 47/339 (13%)

Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203
           E+ K+  D   + + + A M +  L+  + + +A + + +  + A+V  + + S+ +  +
Sbjct: 449 EMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLASDSE-ELHQ 507

Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVR-MLSSPVESVLFYAITTLHNLLLYQEGA 260
             +SIL NLS   +      + ++G + ALV+ +L +  ES L   ++ L NL  +    
Sbjct: 508 VVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLKSVLSALWNLSAHSTEN 567

Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
           K A+   DG              FL  T      L Y  Q + L I+ +GG      I+R
Sbjct: 568 KAAICQVDGALG-----------FLVST------LTYKCQSNSLAIIESGGG-----ILR 605

Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380
           N S   L+ T     +VL           +   +Q L +HLTS+S  +V N   TL NLS
Sbjct: 606 NVS--SLVATREDYRQVLR----------DHNCLQTLLQHLTSHSLTIVSNACGTLWNLS 653

Query: 381 DVATKQE------GLESVLKILV-NQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNS 433
             + + +      G   +L+ LV ++  +  +         L++    +    T V+  S
Sbjct: 654 ARSARDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGS 713

Query: 434 GVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMA 472
            V +L     RA + +        AL HL  + P A  A
Sbjct: 714 CVPSLYVRKQRALEAELDARHLAQALEHLEKQGPPAAEA 752



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 62/253 (24%), Positives = 99/253 (39%), Gaps = 41/253 (16%)

Query: 352 GGMQALGKHLTSNSPRLVQNCLWTLRNLS---DVATKQEGLE--SVLKILVNQLSVDDVN 406
           G M+A+   L S+S  L Q     LRNLS   D+ +K+   E  SV  ++   L     +
Sbjct: 489 GCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKES 548

Query: 407 VLTCATGTLSNLTCNNSKNKTLVTQNSG-----VEALIH-------AILRAG-------- 446
            L      L NL+ ++++NK  + Q  G     V  L +       AI+ +G        
Sbjct: 549 TLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVS 608

Query: 447 -------DKDDITEPAVCA---LRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWP 496
                  D   +     C    L+HLTS      +  N+    + + A     +Q   W 
Sbjct: 609 SLVATREDYRQVLRDHNCLQTLLQHLTSH--SLTIVSNACGTLWNLSAR-SARDQELLWD 665

Query: 497 LVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRM 556
           L    +G++RNL         +  AA +  L+      HQ A   V+ G+  P +  VR 
Sbjct: 666 L--GAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVP-SLYVRK 722

Query: 557 EEIVEGCTGALHI 569
           +  +E    A H+
Sbjct: 723 QRALEAELDARHL 735


>gi|189011568 adenomatous polyposis coli [Homo sapiens]
          Length = 2843

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 33/306 (10%)

Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVR-- 265
           +L  LS   E   A+ + GG+ A+  +L    E    Y +T  H  +  +  A MA+   
Sbjct: 452 VLMKLSFDEEHRHAMNELGGLQAIAELLQVDCE---MYGLTNDHYSITLRRYAGMALTNL 508

Query: 266 -------------LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGG 311
                        +   ++ +V  L   +     +    L+ L++  +  SK  +   G 
Sbjct: 509 TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS 568

Query: 312 PQALVQIMRNYSYEKLLWTTSRVLKVLSV-CPSNKPAIVEAGGMQA-----LGKHLTSNS 365
            +AL++       E  L +    L  LS  C  NK  I    G  A     L     +N+
Sbjct: 569 VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNT 628

Query: 366 PRLVQNCLWTLRNLSDVATKQEGLESVLK------ILVNQLSVDDVNVLTCATGTLSNLT 419
             ++++    LRN+S +    E    +L+       L+  L    + +++ A GTL NL+
Sbjct: 629 LAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688

Query: 420 CNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLN 479
             N K++  +  + G  +++  ++ +  K  I   +  ALR+L +  P      N +   
Sbjct: 689 ARNPKDQEAL-WDMGAVSMLKNLIHSKHK-MIAMGSAAALRNLMANRPAKYKDANIMSPG 746

Query: 480 YGIPAI 485
             +P++
Sbjct: 747 SSLPSL 752



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 65/264 (24%), Positives = 112/264 (42%), Gaps = 46/264 (17%)

Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203
           E+  L ND   + + + A M +  L+  + + +A + S +  + A+V  +++ S+ D  +
Sbjct: 484 EMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESE-DLQQ 542

Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVRM-LSSPVESVLFYAITTLHNLLLYQEGA 260
              S+L NLS   +      + + G + AL+   L    ES L   ++ L NL  +    
Sbjct: 543 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 602

Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
           K  +   DG              FL  T      L Y +Q + L I+ +GG      I+R
Sbjct: 603 KADICAVDGALA-----------FLVGT------LTYRSQTNTLAIIESGGG-----ILR 640

Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380
           N S             +++    ++  + E   +Q L +HL S+S  +V N   TL NLS
Sbjct: 641 NVS------------SLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688

Query: 381 DVATKQE------GLESVLKILVN 398
               K +      G  S+LK L++
Sbjct: 689 ARNPKDQEALWDMGAVSMLKNLIH 712


>gi|189011566 adenomatous polyposis coli [Homo sapiens]
          Length = 2843

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 33/306 (10%)

Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVR-- 265
           +L  LS   E   A+ + GG+ A+  +L    E    Y +T  H  +  +  A MA+   
Sbjct: 452 VLMKLSFDEEHRHAMNELGGLQAIAELLQVDCE---MYGLTNDHYSITLRRYAGMALTNL 508

Query: 266 -------------LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGG 311
                        +   ++ +V  L   +     +    L+ L++  +  SK  +   G 
Sbjct: 509 TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS 568

Query: 312 PQALVQIMRNYSYEKLLWTTSRVLKVLSV-CPSNKPAIVEAGGMQA-----LGKHLTSNS 365
            +AL++       E  L +    L  LS  C  NK  I    G  A     L     +N+
Sbjct: 569 VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNT 628

Query: 366 PRLVQNCLWTLRNLSDVATKQEGLESVLK------ILVNQLSVDDVNVLTCATGTLSNLT 419
             ++++    LRN+S +    E    +L+       L+  L    + +++ A GTL NL+
Sbjct: 629 LAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688

Query: 420 CNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLN 479
             N K++  +  + G  +++  ++ +  K  I   +  ALR+L +  P      N +   
Sbjct: 689 ARNPKDQEAL-WDMGAVSMLKNLIHSKHK-MIAMGSAAALRNLMANRPAKYKDANIMSPG 746

Query: 480 YGIPAI 485
             +P++
Sbjct: 747 SSLPSL 752



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 65/264 (24%), Positives = 112/264 (42%), Gaps = 46/264 (17%)

Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203
           E+  L ND   + + + A M +  L+  + + +A + S +  + A+V  +++ S+ D  +
Sbjct: 484 EMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESE-DLQQ 542

Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVRM-LSSPVESVLFYAITTLHNLLLYQEGA 260
              S+L NLS   +      + + G + AL+   L    ES L   ++ L NL  +    
Sbjct: 543 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 602

Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
           K  +   DG              FL  T      L Y +Q + L I+ +GG      I+R
Sbjct: 603 KADICAVDGALA-----------FLVGT------LTYRSQTNTLAIIESGGG-----ILR 640

Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380
           N S             +++    ++  + E   +Q L +HL S+S  +V N   TL NLS
Sbjct: 641 NVS------------SLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688

Query: 381 DVATKQE------GLESVLKILVN 398
               K +      G  S+LK L++
Sbjct: 689 ARNPKDQEALWDMGAVSMLKNLIH 712


>gi|53759122 adenomatous polyposis coli [Homo sapiens]
          Length = 2843

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 33/306 (10%)

Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVR-- 265
           +L  LS   E   A+ + GG+ A+  +L    E    Y +T  H  +  +  A MA+   
Sbjct: 452 VLMKLSFDEEHRHAMNELGGLQAIAELLQVDCE---MYGLTNDHYSITLRRYAGMALTNL 508

Query: 266 -------------LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGG 311
                        +   ++ +V  L   +     +    L+ L++  +  SK  +   G 
Sbjct: 509 TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGS 568

Query: 312 PQALVQIMRNYSYEKLLWTTSRVLKVLSV-CPSNKPAIVEAGGMQA-----LGKHLTSNS 365
            +AL++       E  L +    L  LS  C  NK  I    G  A     L     +N+
Sbjct: 569 VKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNT 628

Query: 366 PRLVQNCLWTLRNLSDVATKQEGLESVLK------ILVNQLSVDDVNVLTCATGTLSNLT 419
             ++++    LRN+S +    E    +L+       L+  L    + +++ A GTL NL+
Sbjct: 629 LAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688

Query: 420 CNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLN 479
             N K++  +  + G  +++  ++ +  K  I   +  ALR+L +  P      N +   
Sbjct: 689 ARNPKDQEAL-WDMGAVSMLKNLIHSKHK-MIAMGSAAALRNLMANRPAKYKDANIMSPG 746

Query: 480 YGIPAI 485
             +P++
Sbjct: 747 SSLPSL 752



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 65/264 (24%), Positives = 112/264 (42%), Gaps = 46/264 (17%)

Query: 146 ELTKLLNDEDPVVVTK-AAMIVNQLSKKEASRRALMGSPQ-LVAAVVRTMQNTSDLDTAR 203
           E+  L ND   + + + A M +  L+  + + +A + S +  + A+V  +++ S+ D  +
Sbjct: 484 EMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESE-DLQQ 542

Query: 204 CTTSILHNLSHHRE--GLLAIFKSGGIPALVRM-LSSPVESVLFYAITTLHNLLLYQEGA 260
              S+L NLS   +      + + G + AL+   L    ES L   ++ L NL  +    
Sbjct: 543 VIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN 602

Query: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
           K  +   DG              FL  T      L Y +Q + L I+ +GG      I+R
Sbjct: 603 KADICAVDGALA-----------FLVGT------LTYRSQTNTLAIIESGGG-----ILR 640

Query: 321 NYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS 380
           N S             +++    ++  + E   +Q L +HL S+S  +V N   TL NLS
Sbjct: 641 NVS------------SLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLS 688

Query: 381 DVATKQE------GLESVLKILVN 398
               K +      G  S+LK L++
Sbjct: 689 ARNPKDQEALWDMGAVSMLKNLIH 712


>gi|224589129 karyopherin 7 [Homo sapiens]
          Length = 516

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 94/413 (22%), Positives = 159/413 (38%), Gaps = 78/413 (18%)

Query: 270 LQKMVPLLNKNNPK--FLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKL 327
           L +++  +N ++P   F A  T    L    N   KL+I A   P+ +V+ +++  Y  L
Sbjct: 72  LGEIIKGVNSSDPVLCFQATQTARKMLSQEKNPPLKLVIEAGLIPR-MVEFLKSSLYPCL 130

Query: 328 LWTTSRVL-KVLSVCPSNKPAIVEAGGMQALGKHLTSN---------------------- 364
            +  +  L  + S       A+VE G +Q L + L+S+                      
Sbjct: 131 QFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCEQAVWALGNIAGDGPEF 190

Query: 365 -----------------SPRL----VQNCLWTLRNL--------SDVATKQEGLESVLKI 395
                            SP L    ++N  WTL NL         D A KQ     +L  
Sbjct: 191 RDNVITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQ-----ILPA 245

Query: 396 LVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPA 455
           L++ L   D  VL+ A   LS LT  ++K    V  N+GV   +  ++ + + + +T   
Sbjct: 246 LLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVV-NTGVLPRLVVLMTSSELNVLTPSL 304

Query: 456 VCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANH 515
                 +T    + +MA ++  LN     ++  L Q N+  + K     + N+A  P +H
Sbjct: 305 RTVGNIVTGTDEQTQMAIDAGMLN-----VLPQLLQHNKPSIQKEAAWALSNVAAGPCHH 359

Query: 516 -APLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVE----GCTGALHIL 570
              L    V+P LV LL       Q+  A      +  G  M+++++    G    L  L
Sbjct: 360 IQQLLAYDVLPPLVALLKNGEFKVQKE-AVWMVANFATGATMDQLIQLVHSGVLEPLVNL 418

Query: 571 ARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDA 623
              P  ++ +  L+ I   +Q      E         LC L ++    D I+A
Sbjct: 419 LTAPDVKIVLIILDVISCILQAAEKRSEKEN------LCLLIEELGGIDRIEA 465



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 48/230 (20%), Positives = 89/230 (38%), Gaps = 4/230 (1%)

Query: 222 IFKSGGIPALVRMLSSPVESVLFYAIT-TLHNLLLYQEGAKMAVRLADGLQKMVPLLNKN 280
           +  S  IP L+ ++S  +       IT TL NL   +        +   L  ++ LL   
Sbjct: 194 VITSNAIPHLLALISPTLPITFLRNITWTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQ 253

Query: 281 NPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSV 340
           + + L+     L  L  G+ +    ++  G    LV +M +     L  +   V  +++ 
Sbjct: 254 DSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTG 313

Query: 341 CPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVA---TKQEGLESVLKILV 397
                   ++AG +  L + L  N P + +   W L N++       +Q     VL  LV
Sbjct: 314 TDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLV 373

Query: 398 NQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGD 447
             L   +  V   A   ++N     + ++ +   +SGV   +  +L A D
Sbjct: 374 ALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPD 423



 Score = 33.1 bits (74), Expect = 0.96
 Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 6/98 (6%)

Query: 580 IFRLNTIPLFVQLLYSSVEN-IQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR 637
           +     IP  V+ L SS+   +Q  AA  L  +A    E   A+   GA  PL+ELL S 
Sbjct: 109 VIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSS 168

Query: 638 NEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKH 675
           N      A   L  I+ D  P++R  V   +T++   H
Sbjct: 169 NVAVCEQAVWALGNIAGD-GPEFRDNV---ITSNAIPH 202


>gi|6005830 plakophilin 3 [Homo sapiens]
          Length = 797

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 51/217 (23%), Positives = 89/217 (41%), Gaps = 21/217 (9%)

Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSYEKLLW 329
           L   V  L  ++P    +    +Q   Y +  +K    +      LV++  + + E    
Sbjct: 321 LPSAVKYLMASDPNLQVLGAAYIQHKCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRH 380

Query: 330 TTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDV-----AT 384
            T  +  ++     NK A+VE  G+  L + L      L +N    L NLS         
Sbjct: 381 ATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELRKNVTGILWNLSSSDHLKDRL 440

Query: 385 KQEGLESVLKILVNQLS-----------VDDVNVLTCATGTLSNLTCNNSKNKTLVTQNS 433
            ++ LE +  ++++ LS             +  +   ATG L NL+  +   +  + +  
Sbjct: 441 ARDTLEQLTDLVLSPLSGAGGPPLIQQNASEAEIFYNATGFLRNLSSASQATRQKMRECH 500

Query: 434 G-VEALIHAILRAGD----KDDITEPAVCALRHLTSR 465
           G V+AL+ +I  A D    +D   E AVC LR+L+ R
Sbjct: 501 GLVDALVTSINHALDAGKCEDKSVENAVCVLRNLSYR 537


>gi|155030194 RAP1, GTP-GDP dissociation stimulator 1 isoform 2
           [Homo sapiens]
          Length = 607

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 92/422 (21%), Positives = 160/422 (37%), Gaps = 66/422 (15%)

Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323
           +  +V LLN  + + L  T   L  + Y + E +  +   GG Q ++  +R+       +
Sbjct: 92  ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151

Query: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380
            EKLL      ++   +   S +  ++  G +  L K L     +  L + CL    NL+
Sbjct: 152 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 211

Query: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434
           ++ + +E        E ++K+   Q+  D   ++      L+     N   K  + +   
Sbjct: 212 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 267

Query: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483
           VE L+  + +  D   +DDITE        V  L    S     E  + SV  R+   IP
Sbjct: 268 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 327

Query: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543
           +        N   L  A    I N A   AN   + +  ++ +L+ LL        RHV 
Sbjct: 328 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 372

Query: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603
            G             +      AL  LA   +N+ ++         ++ L S +  +Q  
Sbjct: 373 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422

Query: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655
             G L  L   +EAA+ +   G +  L+E L        H+   G +    + L R S+ 
Sbjct: 423 LLGTLRMLIDAQEAAEQL---GKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479

Query: 656 KN 657
           K+
Sbjct: 480 KD 481


>gi|54607053 GCN1 general control of amino-acid synthesis 1-like 1
           [Homo sapiens]
          Length = 2671

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 40/132 (30%), Positives = 60/132 (45%), Gaps = 13/132 (9%)

Query: 266 LADGLQKMVPLLNKNNPKFLAITTDCLQLLAY-GNQESKLIILANGGPQALVQIMRNYSY 324
           L D   K + +     PK+L     C  LL Y  + E K +IL    P     ++R  S 
Sbjct: 223 LLDFYMKNILMSKVKPPKYLL--DSCAPLLRYLSHSEFKDLIL----PTIQKSLLR--SP 274

Query: 325 EKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVAT 384
           E ++ T S +L  +++  S     +  G    L  HL SNSPRL+   +  LRNL+   +
Sbjct: 275 ENVIETISSLLASVTLDLSQYAMDIVKG----LAGHLKSNSPRLMDEAVLALRNLARQCS 330

Query: 385 KQEGLESVLKIL 396
               +ES+ K L
Sbjct: 331 DSSAMESLTKHL 342


>gi|6912478 karyopherin alpha 6 [Homo sapiens]
          Length = 536

 Score = 38.1 bits (87), Expect = 0.030
 Identities = 77/365 (21%), Positives = 139/365 (38%), Gaps = 32/365 (8%)

Query: 107 EGQATNLQRLAEPSQLLKSAIVHLIN-------------YQDDAELATRALPELTKLLND 153
           E +   L++     QL K   V LIN             Y       +    E+ ++L  
Sbjct: 32  EEEGIQLRKQKREQQLFKRRNVELINEEAAMFDSLLMDSYVSSTTGESVITREMVEMLFS 91

Query: 154 EDPVVVTKAAMIVNQLSKKEASRRA--LMGSPQLVAAVVRTMQN----TSDLDTARCTTS 207
           +D  +         +L  KE S     ++ +P++V   V  ++     T   + A   T+
Sbjct: 92  DDSDLQLATTQKFRKLLSKEPSPPIDEVINTPRVVDRFVEFLKRNENCTLQFEAAWALTN 151

Query: 208 ILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLA 267
           I    S   +    + ++G +P  + +L+S  E V   A+  L N+       +  V   
Sbjct: 152 IASGTSQQTK---IVIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNC 208

Query: 268 DGLQKMVPLLNKNNPKFLAITTDC---LQLLAYGNQESKLIILANGGPQALVQIMRNYSY 324
             L  ++ LL K+    L +T +    L  L  G          +     L +++ + S 
Sbjct: 209 SILNPLLTLLTKSTR--LTMTRNAVWALSNLCRGKNPPPEFAKVSPCLPVLSRLLFS-SD 265

Query: 325 EKLLWTTSRVLKVLSVCPSNK-PAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNL---S 380
             LL      L  LS  P+ K  A++++G  + L + L  N  ++    L  + N+    
Sbjct: 266 SDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGD 325

Query: 381 DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIH 440
           D+ T+     S L  L++ LS    ++   A  T+SN+T  N      V   +    LI 
Sbjct: 326 DIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIFPVLIE 385

Query: 441 AILRA 445
            + +A
Sbjct: 386 ILQKA 390



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 2/81 (2%)

Query: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAA-DAIDAEGASAPLMELLHSRN 638
           +     +P+F++LL S  E++Q  A   L  +A D     D +       PL+ LL    
Sbjct: 163 VIEAGAVPIFIELLNSDFEDVQEQAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKST 222

Query: 639 EGTATYAAA-VLFRISEDKNP 658
             T T  A   L  +   KNP
Sbjct: 223 RLTMTRNAVWALSNLCRGKNP 243


>gi|155030196 RAP1, GTP-GDP dissociation stimulator 1 isoform 3
           [Homo sapiens]
          Length = 607

 Score = 37.7 bits (86), Expect = 0.039
 Identities = 91/422 (21%), Positives = 159/422 (37%), Gaps = 65/422 (15%)

Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323
           +  +V LLN  + + L  T   L  + Y + E +  +   GG Q ++  +R+       +
Sbjct: 91  ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 150

Query: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380
            EKLL      ++   +   S +  ++  G +  L K L     +  L + CL    NL+
Sbjct: 151 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 210

Query: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434
           ++ + +E        E ++K+   Q+  D   ++      L+     N   K  + +   
Sbjct: 211 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 266

Query: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483
           VE L+  + +  D   +DDITE        V  L    S     E  + SV  R+   IP
Sbjct: 267 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 326

Query: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543
           +        N   L  A    I N A   AN   + +  ++ +L+ LL        RHV 
Sbjct: 327 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 371

Query: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603
            G             +      AL  LA   +N+ ++         ++ L S +  +Q  
Sbjct: 372 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 421

Query: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655
             G L  L   +  A+A +  G +  L+E L        H+   G +    + L R S+ 
Sbjct: 422 LLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 479

Query: 656 KN 657
           K+
Sbjct: 480 KD 481


>gi|155030192 RAP1, GTP-GDP dissociation stimulator 1 isoform 1
           [Homo sapiens]
          Length = 608

 Score = 37.7 bits (86), Expect = 0.039
 Identities = 91/422 (21%), Positives = 159/422 (37%), Gaps = 65/422 (15%)

Query: 270 LQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY------S 323
           +  +V LLN  + + L  T   L  + Y + E +  +   GG Q ++  +R+       +
Sbjct: 92  ISPLVQLLNSKDQEVLLQTGRALGNICYDSHEGRSAVDQAGGAQIVIDHLRSLCSITDPA 151

Query: 324 YEKLLWT-TSRVLKVLSVCPSNKPAIVEAGGMQALGKHL--TSNSPRLVQNCLWTLRNLS 380
            EKLL      ++   +   S +  ++  G +  L K L     +  L + CL    NL+
Sbjct: 152 NEKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGIHCQNAALTEMCLVAFGNLA 211

Query: 381 DVATKQEGL------ESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSG 434
           ++ + +E        E ++K+   Q+  D   ++      L+     N   K  + +   
Sbjct: 212 ELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA----ENDAIKLQLVEAGL 267

Query: 435 VEALIHAILRAGD---KDDITE------PAVCALRHLTSRHPEAEMAQNSV--RLNYGIP 483
           VE L+  + +  D   +DDITE        V  L    S     E  + SV  R+   IP
Sbjct: 268 VECLLEIVQQKVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGSVFQRVLSWIP 327

Query: 484 AIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVA 543
           +        N   L  A    I N A   AN   + +  ++ +L+ LL        RHV 
Sbjct: 328 S--------NNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLL-------DRHVE 372

Query: 544 AGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRV 603
            G             +      AL  LA   +N+ ++         ++ L S +  +Q  
Sbjct: 373 DGN----------VTVQHAALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFK 422

Query: 604 AAGVLCELAQDKEAADAIDAEGASAPLMELL--------HSRNEGTATYAAAVLFRISED 655
             G L  L   +  A+A +  G +  L+E L        H+   G +    + L R S+ 
Sbjct: 423 LLGTLRMLIDAQ--AEAAEQLGKNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKS 480

Query: 656 KN 657
           K+
Sbjct: 481 KD 482


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,267,538
Number of Sequences: 37866
Number of extensions: 1081431
Number of successful extensions: 2939
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 2614
Number of HSP's gapped (non-prelim): 255
length of query: 745
length of database: 18,247,518
effective HSP length: 110
effective length of query: 635
effective length of database: 14,082,258
effective search space: 8942233830
effective search space used: 8942233830
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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