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Search of human proteins with 4504023
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504023 glycine receptor, beta [Homo sapiens]
(497 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504023 glycine receptor, beta [Homo sapiens] 1005 0.0
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens] 374 e-103
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] 373 e-103
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] 373 e-103
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens] 369 e-102
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens] 369 e-102
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo... 357 2e-98
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo... 355 5e-98
gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens] 335 6e-92
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 275 7e-74
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 265 9e-71
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 265 9e-71
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 258 1e-68
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 253 4e-67
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom... 246 5e-65
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom... 245 6e-65
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec... 239 4e-63
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur... 228 7e-60
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs... 226 5e-59
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre... 224 1e-58
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso... 223 3e-58
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s... 218 1e-56
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 217 2e-56
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s... 214 1e-55
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs... 214 1e-55
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 211 9e-55
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 207 2e-53
gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 207 2e-53
gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 207 2e-53
gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 207 2e-53
>gi|4504023 glycine receptor, beta [Homo sapiens]
Length = 497
Score = 1005 bits (2599), Expect = 0.0
Identities = 497/497 (100%), Positives = 497/497 (100%)
Query: 1 MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNIL 60
MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNIL
Sbjct: 1 MKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNIL 60
Query: 61 NRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPS 120
NRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPS
Sbjct: 61 NRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPS 120
Query: 121 DFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSIT 180
DFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSIT
Sbjct: 121 DFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSIT 180
Query: 181 LSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEY 240
LSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEY
Sbjct: 181 LSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEY 240
Query: 241 GNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVP 300
GNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVP
Sbjct: 241 GNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVP 300
Query: 301 LGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRV 360
LGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRV
Sbjct: 301 LGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRV 360
Query: 361 EAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDF 420
EAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDF
Sbjct: 361 EAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDF 420
Query: 421 SIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARAL 480
SIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARAL
Sbjct: 421 SIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARAL 480
Query: 481 FPFCFLFFNVIYWSIYL 497
FPFCFLFFNVIYWSIYL
Sbjct: 481 FPFCFLFFNVIYWSIYL 497
>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
Length = 452
Score = 374 bits (959), Expect = e-103
Identities = 220/484 (45%), Positives = 285/484 (58%), Gaps = 74/484 (15%)
Query: 20 AYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIP 79
A+ K+ S+ GK PSQ + P++ ++ R YD RIRPNFKG P
Sbjct: 25 AFCKDHDSRSGKQ-------PSQTLS------PSDFLDKLMGRTS-GYDARIRPNFKGPP 70
Query: 80 VDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLW 139
V+V NIFINSFGSI ETTMDYRVNIFLRQ+WND RL S++ D+L +DP+M +W
Sbjct: 71 VNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAY-SEYP-DDSLDLDPSMLDSIW 128
Query: 140 KPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKM 199
KPDLFFANEK ANFHDVT +N LL I ++G VL S+RL++TLSCP+DL FPMD Q C M
Sbjct: 129 KPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTM 188
Query: 200 QLESFGYTTDDLRFIWQSGDPVQL-EKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEV 258
QLESFGYT +DL F W S PVQ+ E + LPQF I KE+ E G CTK+Y TG +TC+EV
Sbjct: 189 QLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQF-ILKEEKELGYCTKHY-NTGKFTCIEV 246
Query: 259 IFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAA 318
F L RQ+G+Y++ +Y P+LLIV+LSW+SFWIN DA+ ARV LGI +VL++ ++ + A
Sbjct: 247 KFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRA 306
Query: 319 ELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGG 378
LPKVSYVKA+D+W+ CLLF FA+L+EYA V N R E R+ + ++ K
Sbjct: 307 SLPKVSYVKAIDIWMAVCLLFVFAALLEYAAV----NFVSRQHKEFLRLRRRQKRQNKEE 362
Query: 379 NVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCY 438
+V +++ N +G +
Sbjct: 363 DVTRESRFNFSGYGM--------------------------------------------- 377
Query: 439 GKPIEVNNGLGKSQAKNNKKPPP------AKPVIPTAAKRIDLYARALFPFCFLFFNVIY 492
G ++V +G N P P K AKRID +RA FP FL FN+ Y
Sbjct: 378 GHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFY 437
Query: 493 WSIY 496
W Y
Sbjct: 438 WITY 441
>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 373 bits (958), Expect = e-103
Identities = 219/484 (45%), Positives = 285/484 (58%), Gaps = 74/484 (15%)
Query: 20 AYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIP 79
A+ K+ S+ GK PSQ + P++ ++ R YD RIRPNFKG P
Sbjct: 25 AFCKDHDSRSGKQ-------PSQTLS------PSDFLDKLMGRTS-GYDARIRPNFKGPP 70
Query: 80 VDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLW 139
V+V NIFINSFGS+ ETTMDYRVNIFLRQ+WND RL S++ D+L +DP+M +W
Sbjct: 71 VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAY-SEYP-DDSLDLDPSMLDSIW 128
Query: 140 KPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKM 199
KPDLFFANEK ANFHDVT +N LL I ++G VL S+RL++TLSCP+DL FPMD Q C M
Sbjct: 129 KPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTM 188
Query: 200 QLESFGYTTDDLRFIWQSGDPVQL-EKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEV 258
QLESFGYT +DL F W S PVQ+ E + LPQF I KE+ E G CTK+Y TG +TC+EV
Sbjct: 189 QLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQF-ILKEEKELGYCTKHY-NTGKFTCIEV 246
Query: 259 IFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAA 318
F L RQ+G+Y++ +Y P+LLIV+LSW+SFWIN DA+ ARV LGI +VL++ ++ + A
Sbjct: 247 KFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRA 306
Query: 319 ELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGG 378
LPKVSYVKA+D+W+ CLLF FA+L+EYA V N R E R+ + ++ K
Sbjct: 307 SLPKVSYVKAIDIWMAVCLLFVFAALLEYAAV----NFVSRQHKEFLRLRRRQKRQNKEE 362
Query: 379 NVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCY 438
+V +++ N +G +
Sbjct: 363 DVTRESRFNFSGYGM--------------------------------------------- 377
Query: 439 GKPIEVNNGLGKSQAKNNKKPPP------AKPVIPTAAKRIDLYARALFPFCFLFFNVIY 492
G ++V +G N P P K AKRID +RA FP FL FN+ Y
Sbjct: 378 GHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFY 437
Query: 493 WSIY 496
W Y
Sbjct: 438 WITY 441
>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 373 bits (958), Expect = e-103
Identities = 219/484 (45%), Positives = 285/484 (58%), Gaps = 74/484 (15%)
Query: 20 AYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIP 79
A+ K+ S+ GK PSQ + P++ ++ R YD RIRPNFKG P
Sbjct: 25 AFCKDHDSRSGKQ-------PSQTLS------PSDFLDKLMGRTS-GYDARIRPNFKGPP 70
Query: 80 VDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLW 139
V+V NIFINSFGS+ ETTMDYRVNIFLRQ+WND RL S++ D+L +DP+M +W
Sbjct: 71 VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAY-SEYP-DDSLDLDPSMLDSIW 128
Query: 140 KPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKM 199
KPDLFFANEK ANFHDVT +N LL I ++G VL S+RL++TLSCP+DL FPMD Q C M
Sbjct: 129 KPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTM 188
Query: 200 QLESFGYTTDDLRFIWQSGDPVQL-EKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEV 258
QLESFGYT +DL F W S PVQ+ E + LPQF I KE+ E G CTK+Y TG +TC+EV
Sbjct: 189 QLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQF-ILKEEKELGYCTKHY-NTGKFTCIEV 246
Query: 259 IFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAA 318
F L RQ+G+Y++ +Y P+LLIV+LSW+SFWIN DA+ ARV LGI +VL++ ++ + A
Sbjct: 247 KFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRA 306
Query: 319 ELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGG 378
LPKVSYVKA+D+W+ CLLF FA+L+EYA V N R E R+ + ++ K
Sbjct: 307 SLPKVSYVKAIDIWMAVCLLFVFAALLEYAAV----NFVSRQHKEFLRLRRRQKRQNKEE 362
Query: 379 NVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCY 438
+V +++ N +G +
Sbjct: 363 DVTRESRFNFSGYGM--------------------------------------------- 377
Query: 439 GKPIEVNNGLGKSQAKNNKKPPP------AKPVIPTAAKRIDLYARALFPFCFLFFNVIY 492
G ++V +G N P P K AKRID +RA FP FL FN+ Y
Sbjct: 378 GHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFY 437
Query: 493 WSIY 496
W Y
Sbjct: 438 WITY 441
>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
Length = 464
Score = 369 bits (948), Expect = e-102
Identities = 217/471 (46%), Positives = 289/471 (61%), Gaps = 56/471 (11%)
Query: 38 LCPSQQSAEDLARVPANSTSNILNRLL---VSYDPRIRPNFKGIPVDVVVNIFINSFGSI 94
L ++++ +R S S+ L++L+ YD RIRPNFKG PV+V NIFINSFGSI
Sbjct: 25 LVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSI 84
Query: 95 QETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFH 154
ETTMDYRVNIFLRQKWNDPRL S++ D+L +DP+M +WKPDLFFANEK ANFH
Sbjct: 85 AETTMDYRVNIFLRQKWNDPRLAY-SEYP-DDSLDLDPSMLDSIWKPDLFFANEKGANFH 142
Query: 155 DVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFI 214
+VT +N LL IF++G+VL S+RL++TLSCP+DL FPMD Q C MQLESFGYT +DL F
Sbjct: 143 EVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFE 202
Query: 215 WQSGDPVQL-EKIALPQFDIKKE-DIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMG 272
WQ PVQ+ E + LPQF +K+E D+ Y CTK+Y TG +TC+EV F L RQ+G+Y++
Sbjct: 203 WQDEAPVQVAEGLTLPQFLLKEEKDLRY--CTKHY-NTGKFTCIEVRFHLERQMGYYLIQ 259
Query: 273 VYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVW 332
+Y P+LLIV+LSW+SFWIN DA+ ARV LGI +VL++ ++ + A LPKVSYVKA+D+W
Sbjct: 260 MYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIW 319
Query: 333 LIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTP 392
+ CLLF F++L+EYA V N R E R + +KN
Sbjct: 320 MAVCLLFVFSALLEYAAV----NFVSRQHKELLRFRR-----------KRKN-------- 356
Query: 393 VHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKP--IEVNNGLGK 450
T + + ++R + FS + YG ++ +G+
Sbjct: 357 ---KTEAFALEKFYRFSDMDDEVRESRFS-------------FTAYGMGPCLQAKDGMTP 400
Query: 451 SQAKNNKKPPPAKP-----VIPTAAKRIDLYARALFPFCFLFFNVIYWSIY 496
+ + P P V AK+ID +RA FP FL FN+ YW IY
Sbjct: 401 KGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 451
>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
Length = 449
Score = 369 bits (946), Expect = e-102
Identities = 217/464 (46%), Positives = 285/464 (61%), Gaps = 57/464 (12%)
Query: 38 LCPSQQSAEDLARVPANSTSNILNRLL---VSYDPRIRPNFKGIPVDVVVNIFINSFGSI 94
L ++++ +R S S+ L++L+ YD RIRPNFKG PV+V NIFINSFGSI
Sbjct: 25 LVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSI 84
Query: 95 QETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFH 154
ETTMDYRVNIFLRQKWNDPRL S++ D+L +DP+M +WKPDLFFANEK ANFH
Sbjct: 85 AETTMDYRVNIFLRQKWNDPRLAY-SEYP-DDSLDLDPSMLDSIWKPDLFFANEKGANFH 142
Query: 155 DVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFI 214
+VT +N LL IF++G+VL S+RL++TLSCP+DL FPMD Q C MQLESFGYT +DL F
Sbjct: 143 EVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFE 202
Query: 215 WQSGDPVQL-EKIALPQFDIKKE-DIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMG 272
WQ PVQ+ E + LPQF +K+E D+ Y CTK+Y TG +TC+EV F L RQ+G+Y++
Sbjct: 203 WQDEAPVQVAEGLTLPQFLLKEEKDLRY--CTKHY-NTGKFTCIEVRFHLERQMGYYLIQ 259
Query: 273 VYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVW 332
+Y P+LLIV+LSW+SFWIN DA+ ARV LGI +VL++ ++ + A LPKVSYVKA+D+W
Sbjct: 260 MYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIW 319
Query: 333 LIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTP 392
+ CLLF F++L+EYA V + K + + K + D + T G G
Sbjct: 320 MAVCLLFVFSALLEYAAVNFVSRQHKELLRFR---RKRKNKDDEVRESRFSFTAYGMGP- 375
Query: 393 VHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQ 452
C D G P+ P++V + KS
Sbjct: 376 ----------------CLQAKD---------GMTPKG--------PNHPVQV---MPKS- 398
Query: 453 AKNNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIY 496
P + V AK+ID +RA FP FL FN+ YW IY
Sbjct: 399 ------PDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 436
>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 449
Score = 357 bits (915), Expect = 2e-98
Identities = 208/457 (45%), Positives = 272/457 (59%), Gaps = 70/457 (15%)
Query: 55 STSNILNRLL---VSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKW 111
S S+ L++L+ YD RIRPNFKG PV+V NIFINSFGSI ETTMDYRVNIFLRQ+W
Sbjct: 37 SPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQW 96
Query: 112 NDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDV 171
NDPRL D+L +DP+M +WKPDLFFANEK A+FH++T +N LL I R+G+V
Sbjct: 97 NDPRLAYNE--YPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNV 154
Query: 172 LVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQL-EKIALPQ 230
L S+R+++TL+CP+DL FPMD Q C MQLESFGYT +DL F WQ VQ+ + + LPQ
Sbjct: 155 LYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQ 214
Query: 231 FDIKKE-DIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFW 289
F +K+E D+ Y CTK+Y TG +TC+E F L RQ+G+Y++ +Y P+LLIV+LSW+SFW
Sbjct: 215 FILKEEKDLRY--CTKHYN-TGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFW 271
Query: 290 INPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAV 349
IN DA+ ARV LGI +VL++ ++ + A LPKVSYVKA+D+W+ CLLF F++L+EYA
Sbjct: 272 INMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAA 331
Query: 350 VQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVC 409
V N R E R + + H + GE R
Sbjct: 332 V----NFVSRQHKELLRFRRKRR---------------------HHKEDEAGEGR----- 361
Query: 410 TSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNK--KPPPAKPVIP 467
F S Y ++ +G+ A N+ PPPA P
Sbjct: 362 --------------------FNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSP 401
Query: 468 --------TAAKRIDLYARALFPFCFLFFNVIYWSIY 496
AK+ID +R FP FL FN+ YW IY
Sbjct: 402 EEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 438
>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 457
Score = 355 bits (911), Expect = 5e-98
Identities = 208/459 (45%), Positives = 277/459 (60%), Gaps = 66/459 (14%)
Query: 55 STSNILNRLL---VSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKW 111
S S+ L++L+ YD RIRPNFKG PV+V NIFINSFGSI ETTMDYRVNIFLRQ+W
Sbjct: 37 SPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQW 96
Query: 112 NDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDV 171
NDPRL D+L +DP+M +WKPDLFFANEK A+FH++T +N LL I R+G+V
Sbjct: 97 NDPRLAYNE--YPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNV 154
Query: 172 LVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQL-EKIALPQ 230
L S+R+++TL+CP+DL FPMD Q C MQLESFGYT +DL F WQ VQ+ + + LPQ
Sbjct: 155 LYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQ 214
Query: 231 FDIKKE-DIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFW 289
F +K+E D+ Y CTK+Y TG +TC+E F L RQ+G+Y++ +Y P+LLIV+LSW+SFW
Sbjct: 215 FILKEEKDLRY--CTKHYN-TGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFW 271
Query: 290 INPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAV 349
IN DA+ ARV LGI +VL++ ++ + A LPKVSYVKA+D+W+ CLLF F++L+EYA
Sbjct: 272 INMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAA 331
Query: 350 VQVMLNNPKRV--EAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKK 407
V + K + K R K+ N+ +++ + GE R
Sbjct: 332 VNFVSRQHKELLRFRRKRRHHKSPML-----NLFQED--------------EAGEGR--- 369
Query: 408 VCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNK--KPPPAKPV 465
F S Y ++ +G+ A N+ PPPA
Sbjct: 370 ----------------------FNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSK 407
Query: 466 IP--------TAAKRIDLYARALFPFCFLFFNVIYWSIY 496
P AK+ID +R FP FL FN+ YW IY
Sbjct: 408 SPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIY 446
>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
Length = 417
Score = 335 bits (859), Expect = 6e-92
Identities = 174/309 (56%), Positives = 226/309 (73%), Gaps = 9/309 (2%)
Query: 55 STSNILNRLL---VSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKW 111
S S+ L++L+ YD RIRPNFKG PV+V NIFINSF SI +TTMDYRVN+FLRQ+W
Sbjct: 43 SPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQW 102
Query: 112 NDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDV 171
NDPRL D+L +DP+M +WKPDLFFANEK ANFH+VT +N LL IF++G+V
Sbjct: 103 NDPRLSYRE--YPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNV 160
Query: 172 LVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDP-VQL-EKIALP 229
L S+RL++ LSC +DL FPMD Q C MQLESFGYT DL F W P VQ+ E + LP
Sbjct: 161 LYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLP 220
Query: 230 QFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFW 289
QF I +++ + G CTK+Y TG +TC+EV F L RQ+G+Y++ +Y P+LLIV+LSW+SFW
Sbjct: 221 QF-ILRDEKDLGCCTKHYN-TGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFW 278
Query: 290 INPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAV 349
IN DA+ ARV LGI +VL++ ++ + A LPKVSYVKA+D+W+ CLLF FA+L+EYA
Sbjct: 279 INMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAA 338
Query: 350 VQVMLNNPK 358
+ + K
Sbjct: 339 INFVSRQHK 347
>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
Length = 474
Score = 275 bits (703), Expect = 7e-74
Identities = 162/446 (36%), Positives = 252/446 (56%), Gaps = 21/446 (4%)
Query: 60 LNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLP 119
++RLL YD R+RP+F G PVDV + I + S + E MDY + ++ +Q W D RL
Sbjct: 41 VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLS-- 98
Query: 120 SDFRGSDA-LTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLS 178
+ G LT+D + LW PD +F N+K + H VT +N ++ + DG VL +R++
Sbjct: 99 --YSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156
Query: 179 ITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQ--LEKIALPQFDIKKE 236
T +C +DL +P+D Q C +++ES+GYTTDD+ F W G+ + KI LPQF I
Sbjct: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSI--- 213
Query: 237 DIEYGNCTKYYK-GTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDAS 295
++Y +K + TG Y + + F L+R +G++++ Y P+ LI +LSW+SFWIN DAS
Sbjct: 214 -VDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDAS 272
Query: 296 AARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVML- 354
AARV LGI +VL++ + T L LPK+ YVKA+D++L+ C +F F +L+EYA V +
Sbjct: 273 AARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFF 332
Query: 355 -NNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQV-GETRCKKVCTSK 412
P++ A K + + A+ K K V+ G + +STL++ ET +V TS
Sbjct: 333 GKGPQKKGASK----QDQSANEKNKLEMNKVQVDAHGN-ILLSTLEIRNETSGSEVLTSV 387
Query: 413 SDLRSNDFSI-VGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAK 471
SD ++ +S S+ LS+ + YG+ ++ + K + + K T
Sbjct: 388 SDPKATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVN 447
Query: 472 RIDLYARALFPFCFLFFNVIYWSIYL 497
ID ++R FP F FNV+YW Y+
Sbjct: 448 SIDKWSRMFFPITFSLFNVVYWLYYV 473
>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
Length = 473
Score = 265 bits (676), Expect = 9e-71
Identities = 160/451 (35%), Positives = 250/451 (55%), Gaps = 32/451 (7%)
Query: 60 LNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLP 119
+++LL YD R+RP+F G PV V +NI I S + E MDY + ++ +Q W D RL
Sbjct: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLA-- 98
Query: 120 SDFRGSDA-LTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLS 178
+ G LT+D + LW PD +F N+K + H VT +N ++ + DG VL +R++
Sbjct: 99 --YSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156
Query: 179 ITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQ--LEKIALPQFDIKKE 236
T +C +DL +P+D Q C +++ES+GYTTDD+ F W+ GD +E+I LPQF I +
Sbjct: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216
Query: 237 DIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASA 296
+ N TG Y + + F L+R +G++++ Y P++LI +LSW+SFWIN DASA
Sbjct: 217 RLVSRNVVF---ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASA 273
Query: 297 ARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVML-- 354
ARV LGI +VL++ + T L LPK+ YVKA+D++L+ C +F F +L+EYA V +
Sbjct: 274 ARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFG 333
Query: 355 NNPKRVE--AEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQV----GETRCKKV 408
P+R + AEK AK +++ + V + T VH +V G+TR +
Sbjct: 334 RGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAI 393
Query: 409 CTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIP- 467
S ++ S+PR + +G+ + + L + ++ K IP
Sbjct: 394 SFDNSGIQYRK----QSMPR-------EGHGRFLG-DRSLPHKKTHLRRRSSQLKIKIPD 441
Query: 468 -TAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
T ID ++R +FPF F FN++YW Y+
Sbjct: 442 LTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV 472
>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 1 precursor [Homo sapiens]
Length = 473
Score = 265 bits (676), Expect = 9e-71
Identities = 160/451 (35%), Positives = 250/451 (55%), Gaps = 32/451 (7%)
Query: 60 LNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLP 119
+++LL YD R+RP+F G PV V +NI I S + E MDY + ++ +Q W D RL
Sbjct: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLA-- 98
Query: 120 SDFRGSDA-LTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLS 178
+ G LT+D + LW PD +F N+K + H VT +N ++ + DG VL +R++
Sbjct: 99 --YSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 156
Query: 179 ITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQ--LEKIALPQFDIKKE 236
T +C +DL +P+D Q C +++ES+GYTTDD+ F W+ GD +E+I LPQF I +
Sbjct: 157 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEH 216
Query: 237 DIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASA 296
+ N TG Y + + F L+R +G++++ Y P++LI +LSW+SFWIN DASA
Sbjct: 217 RLVSRNVVF---ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASA 273
Query: 297 ARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVML-- 354
ARV LGI +VL++ + T L LPK+ YVKA+D++L+ C +F F +L+EYA V +
Sbjct: 274 ARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFG 333
Query: 355 NNPKRVE--AEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQV----GETRCKKV 408
P+R + AEK AK +++ + V + T VH +V G+TR +
Sbjct: 334 RGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAI 393
Query: 409 CTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIP- 467
S ++ S+PR + +G+ + + L + ++ K IP
Sbjct: 394 SFDNSGIQYRK----QSMPR-------EGHGRFLG-DRSLPHKKTHLRRRSSQLKIKIPD 441
Query: 468 -TAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
T ID ++R +FPF F FN++YW Y+
Sbjct: 442 LTDVNAIDRWSRIVFPFTFSLFNLVYWLYYV 472
>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
Length = 474
Score = 258 bits (658), Expect = 1e-68
Identities = 161/457 (35%), Positives = 245/457 (53%), Gaps = 42/457 (9%)
Query: 60 LNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLK-- 117
++RLL YD R+RP+F G PV V +NI I S + E MDY + ++ +Q W D RL
Sbjct: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
Query: 118 -LPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMR 176
+P + LT+D + LW PD +F N+K + H VT +N ++ + DG VL +R
Sbjct: 100 VIPLN------LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLR 153
Query: 177 LSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQ--LEKIALPQFDIK 234
++ T +C +DL +P+D Q C +++ES+GYTTDD+ F W+ D + KI LPQF I
Sbjct: 154 ITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSI- 212
Query: 235 KEDIEYGNCTKYYK-GTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPD 293
++Y TK TG Y + + F L+R +G++++ Y P++LI +LSW+SFWIN D
Sbjct: 213 ---VDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYD 269
Query: 294 ASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVM 353
ASAARV LGI +VL++ + T L LPK+ YVKA+D++L+ C +F F +L+EYA+V +
Sbjct: 270 ASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYI 329
Query: 354 L--NNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHI--STLQV-GETRCKKV 408
P+R + KA + N + VN +I STL++ E +
Sbjct: 330 FFGRGPQRQK-------KAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEA 382
Query: 409 CTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIE------VNNGLGKSQAKNNKKPPPA 462
D RS L D Y G P + + + +++ ++
Sbjct: 383 VMGLGDPRST------MLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQL 436
Query: 463 KPVIP--TAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
K IP T ID ++R FP F FFN++YW Y+
Sbjct: 437 KITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYV 473
>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 1 [Homo sapiens]
Length = 512
Score = 253 bits (645), Expect = 4e-67
Identities = 164/483 (33%), Positives = 256/483 (53%), Gaps = 56/483 (11%)
Query: 60 LNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLK-- 117
++RLL YD R+RP+F G PV V +NI I S + E MDY + ++ +Q W D RL
Sbjct: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
Query: 118 -LPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMR 176
+P + LT+D + LW PD +F N+K + H VT +N ++ + DG VL +R
Sbjct: 100 VIPLN------LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLR 153
Query: 177 LSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQ--LEKIALPQFDIK 234
++ T +C +DL +P+D Q C +++ES+GYTTDD+ F W+ D + KI LPQF I
Sbjct: 154 ITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSI- 212
Query: 235 KEDIEYGNCTKYYK-GTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPD 293
++Y TK TG Y + + F L+R +G++++ Y P++LI +LSW+SFWIN D
Sbjct: 213 ---VDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYD 269
Query: 294 ASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVM 353
ASAARV LGI +VL++ + T L LPK+ YVKA+D++L+ C +F F +L+EYA+V +
Sbjct: 270 ASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYI 329
Query: 354 L--NNPKRVE--AEKARIAKAEQ----------ADGKGGNVAKKNTVNGTGT-------- 391
P+R + AEKA A E+ D K ++ + TG
Sbjct: 330 FFGRGPQRQKKAAEKAASANNEKMRLDVNKIFYKDIKQNGTQYRSLWDPTGNLSPTRRTT 389
Query: 392 --PVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDC----YGKPIEVN 445
+ T+ E K+++ +++ + PR L+ YD Y K
Sbjct: 390 NYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLA-YDASSIQYRKAGLPR 448
Query: 446 NGLGKS---------QAKNNKKPPPAKPVIP--TAAKRIDLYARALFPFCFLFFNVIYWS 494
+ G++ +++ ++ K IP T ID ++R FP F FFN++YW
Sbjct: 449 HSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWL 508
Query: 495 IYL 497
Y+
Sbjct: 509 YYV 511
>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
sapiens]
Length = 479
Score = 246 bits (627), Expect = 5e-65
Identities = 161/488 (32%), Positives = 260/488 (53%), Gaps = 64/488 (13%)
Query: 27 SKKGKGKKKQ---------YLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKG 77
SKKG+ ++++ + P + + D+ + P + +L + +D +RP F G
Sbjct: 37 SKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLR--IDDHDFSMRPGFGG 94
Query: 78 IPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKC 137
+ V V++ + S SI E MD+ + ++LR W D RL PS + ++T D + K
Sbjct: 95 PAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPST--NNLSMTFDGRLVKK 152
Query: 138 LWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRC 197
+W PD+FF + K + HD T +N++L + DG VL S+R+++T C +D + FP+DTQ C
Sbjct: 153 IWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTC 212
Query: 198 KMQLESFGYTTDDLRFIWQSG-DPVQL-EKIALPQFDIKKEDIEYGNCTK--YYKGTGYY 253
+++ES+ YT DDL W+ G D ++ E+I+L QF I+ E+ TK +Y TG+Y
Sbjct: 213 SLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQ----EFHTTTKLAFYSSTGWY 268
Query: 254 TCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASEC 313
+ + FTLRR + F+++ Y P L+V+LSW+SFWI+ A ARVPLGI +VL++++
Sbjct: 269 NRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTII 328
Query: 314 TTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQA 373
T + A +P+VSY+KA+D++L +F F S++EYA V + +R E +K R
Sbjct: 329 TGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKE-QKLR------- 380
Query: 374 DGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELS 433
K +G P R + + SD ND +P + E
Sbjct: 381 -------EKLPCTSGLPPP-----------RTAMLDGNYSDGEVNDLD--NYMPENGE-- 418
Query: 434 NYDCYGKP--IEVNNGLGKSQAKNNKKPPPAKPV---IPTAAKRIDLYARALFPFCFLFF 488
KP + V L ++ +K + V I T A ID Y+R +FP ++ F
Sbjct: 419 ------KPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHA--IDKYSRIIFPAAYILF 470
Query: 489 NVIYWSIY 496
N+IYWSI+
Sbjct: 471 NLIYWSIF 478
>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
sapiens]
Length = 467
Score = 245 bits (626), Expect = 6e-65
Identities = 146/433 (33%), Positives = 232/433 (53%), Gaps = 39/433 (9%)
Query: 68 DPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDA 127
D +RP F G PV V +++ + S SI ET MD+ + +LR W D RL PS + +
Sbjct: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPST--ANKS 128
Query: 128 LTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDL 187
+T D + + +W PD+FF + K + HD T ENI+L + DG+VL+S+R++++ C +D
Sbjct: 129 MTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDF 188
Query: 188 TLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPV--QLEKIALPQFDIKKEDIEYGNCTK 245
+ FP+DTQ C ++LES+ Y DDL W+ G+ E ++L QF I ED +
Sbjct: 189 SRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFI--EDFSASSGLA 246
Query: 246 YYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFS 305
+Y TG+Y + + F LRR V F+++ Y P +L+V+LSW+SFWI+ A ARV LGI +
Sbjct: 247 FYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITT 306
Query: 306 VLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEK- 364
VL++++ T ++A +P+VSY+KA+DV+L LF F S++EYA V + +R + +K
Sbjct: 307 VLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKT 366
Query: 365 ARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVG 424
+I++ D + +G H S + + +T L S DF
Sbjct: 367 GKISRMYNID-----AVQAMAFDGC---YHDSEIDMDQT--------SLSLNSEDFM--- 407
Query: 425 SLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARALFPFC 484
R + + I+ LG + +I ID Y+R LFP
Sbjct: 408 ---RRKSICSPSTDSSRIKRRKSLGGHVGR----------IILENNHVIDTYSRILFPIV 454
Query: 485 FLFFNVIYWSIYL 497
++ FN+ YW +Y+
Sbjct: 455 YILFNLFYWGVYV 467
>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
precursor [Homo sapiens]
Length = 490
Score = 239 bits (610), Expect = 4e-63
Identities = 151/435 (34%), Positives = 237/435 (54%), Gaps = 39/435 (8%)
Query: 67 YDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSD 126
+D +RP F G + V V++ + S SI E MD+ + ++LR W D RL S +
Sbjct: 89 HDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSS--ASNK 146
Query: 127 ALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLD 186
++T D + K +W PD+FF + K + HD T +NI+L +F DG VL SMR+++T C +D
Sbjct: 147 SMTFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMD 206
Query: 187 LTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQL--EKIALPQFDIKKEDIEYGNCT 244
+ FP+D+Q C ++LES+ YT +DL W++GD EKI+L QF I+K +
Sbjct: 207 FSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQK--FHTTSRL 264
Query: 245 KYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIF 304
+Y TG+Y + + FTLRR + F+++ Y P L+V+LSW+SFWI+ A ARV LGI
Sbjct: 265 AFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGIT 324
Query: 305 SVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEK 364
+VL++ + T + A +P+VSYVKA+D++L +F F S++EYA V + V+ K
Sbjct: 325 TVLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTT----VQERK 380
Query: 365 ARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVG 424
R + + G +K ++G+ S+S+ S +
Sbjct: 381 ERKLREKFPCMCGMLHSKTMMLDGS--------------------YSESEANS-----LA 415
Query: 425 SLPRDFELSNYDCYGKPIEVNNGL-GKSQAKNNKKPPPAKP--VIPTAAKRIDLYARALF 481
PR L+ + K I V+ GL G++ A K + I ID Y+R +F
Sbjct: 416 GYPRSHILTEEERQDK-IVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHAIDKYSRLIF 474
Query: 482 PFCFLFFNVIYWSIY 496
P ++FFN+IYWS++
Sbjct: 475 PASYIFFNLIYWSVF 489
>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
[Homo sapiens]
Length = 632
Score = 228 bits (582), Expect = 7e-60
Identities = 126/330 (38%), Positives = 190/330 (57%), Gaps = 14/330 (4%)
Query: 59 ILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKL 118
IL+R+L YD R+RPNF G PV V ++I++ S I E MDY + +F Q W D RL
Sbjct: 62 ILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAY 121
Query: 119 PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLS 178
+ + LT+D M++ LW PD +F N K A HDVT EN + + DG V +RL+
Sbjct: 122 ---YETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLT 178
Query: 179 ITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQ-SGDPVQL-EKIALPQFDIKKE 236
T +C LDL FPMD Q C + +ES+GYT +D+ W +G+ + + E++ +PQF
Sbjct: 179 TTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGR 238
Query: 237 DIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASA 296
I + Y TG Y + + F ++R+V Y++ VY PT+L + SW+SFW+N D+SA
Sbjct: 239 TI---TSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSA 295
Query: 297 ARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVML-- 354
ARV +G+ S+L L + + L +LP +S +KA+D++++ CL F F SL+EY + +
Sbjct: 296 ARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYS 355
Query: 355 ----NNPKRVEAEKARIAKAEQADGKGGNV 380
P+R + IA+ GNV
Sbjct: 356 RGPRRQPRRHRRPRRVIARYRYQQVVVGNV 385
Score = 33.1 bits (74), Expect = 0.60
Identities = 11/31 (35%), Positives = 19/31 (61%)
Query: 467 PTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
P ++D ++R LFP F FN++YW ++
Sbjct: 601 PDYVPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
[Homo sapiens]
Length = 453
Score = 226 bits (575), Expect = 5e-59
Identities = 142/451 (31%), Positives = 228/451 (50%), Gaps = 44/451 (9%)
Query: 53 ANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWN 112
+ + S IL+ LL YD R+RP F G +V +I++ SFG + + M+Y +++F RQ W
Sbjct: 29 SENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWT 88
Query: 113 DPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVL 172
D RLK ++ L+++ M +W PD FF N K + H++T N L I ++G +L
Sbjct: 89 DERLKFGGP---TEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTIL 145
Query: 173 VSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGD----PVQLEKIAL 228
+MRL+I CP+ L FPMD C ++ S+ Y ++ + W+ G V E +L
Sbjct: 146 YTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSL 205
Query: 229 PQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSF 288
Q+D+ + + + TG Y + V F L+R++G++M+ +Y P ++ V+LS +SF
Sbjct: 206 LQYDLIGQTV---SSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSF 262
Query: 289 WINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYA 348
WIN ++ AR GI +VL++ + + LPKVSY A+D ++ C F F++L+E+A
Sbjct: 263 WINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFA 322
Query: 349 VVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKV 408
V N ++ +KA+ KA+ A ++K +H + + KK
Sbjct: 323 AVNYFTN----LQTQKAK-RKAQFAAPPTVTISKATEPLEAEIVLHPDS----KYHLKKR 373
Query: 409 CTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNK--KPPPAKPVI 466
TS S IV S E N L ++ + PPP P
Sbjct: 374 ITSLS------LPIVSS----------------SEANKVLTRAPILQSTPVTPPPLSPAF 411
Query: 467 PTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
+K ID Y+R LFP F FN++YW +YL
Sbjct: 412 GGTSK-IDQYSRILFPVAFAGFNLVYWVVYL 441
>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
precursor [Homo sapiens]
Length = 452
Score = 224 bits (572), Expect = 1e-58
Identities = 146/439 (33%), Positives = 231/439 (52%), Gaps = 34/439 (7%)
Query: 60 LNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLP 119
L+ L+ Y RP G PV+V + + + S I E M+Y + +FL Q W D RL
Sbjct: 44 LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRL--- 100
Query: 120 SDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSI 179
S ++ L +D LW PD F N KSA FHDVT EN L+ + DG +L S+R++
Sbjct: 101 SYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITS 160
Query: 180 TLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIW-QSGDPVQ-LEKIALPQFDIKKED 237
T++C +DL +PMD Q C + LES+GY+++D+ + W +S + + L+K+ L QF I
Sbjct: 161 TVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITS-- 218
Query: 238 IEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAA 297
+ +K G + + + F LRR G Y++ Y P++L+V +SW+SFWI+ A A
Sbjct: 219 YRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPA 278
Query: 298 RVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNP 357
RV LGI +VL++ + + + LP+ S +KALDV+ C +F FA+LVEYA +
Sbjct: 279 RVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYR 338
Query: 358 KRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRS 417
K+ +A K ++++ + +N + V S G T +++ S+ R
Sbjct: 339 KKQKA-KVKVSRPR------AEMDVRNAI------VLFSLSAAGVT--QELAISRRQRR- 382
Query: 418 NDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYA 477
+ G+L + +Y G +E + A++ + + P A ID+YA
Sbjct: 383 ----VPGNL-----MGSYRSVG--VETGETKKEGAARSGGQGGIRARLRPIDADTIDIYA 431
Query: 478 RALFPFCFLFFNVIYWSIY 496
RA+FP F NVIYW+ Y
Sbjct: 432 RAVFPAAFAAVNVIYWAAY 450
>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
[Homo sapiens]
Length = 554
Score = 223 bits (568), Expect = 3e-58
Identities = 150/518 (28%), Positives = 236/518 (45%), Gaps = 69/518 (13%)
Query: 40 PSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTM 99
P Q E+ ++ + + IL+ LL YD R+RP F G +V +I++ SFG + + M
Sbjct: 34 PGQNQKEE--KLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEM 91
Query: 100 DYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQE 159
+Y +++F RQ W D RLK + L ++ M +W PD FF N K + H++T
Sbjct: 92 EYTMDVFFRQTWIDKRLKYDGPI---EILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAP 148
Query: 160 NILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGD 219
N L I R+G +L +MRL+I+ CP+ L FPMD C ++ S+ Y ++ + W G
Sbjct: 149 NKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGP 208
Query: 220 P----VQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYA 275
V E +L Q+D+ + + TG Y + V F LRR++G++M+ Y
Sbjct: 209 EKSVEVPKESSSLVQYDLIGQTVSSETIKSI---TGEYIVMTVYFHLRRKMGYFMIQTYI 265
Query: 276 PTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIA 335
P ++ V+LS +SFWIN ++ AR GI +VL++ + + LPKVSY A+D ++
Sbjct: 266 PCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAV 325
Query: 336 CLLFGFASLVEYAVVQVMLN------------NPKRVEAEKARIAKAEQADGKGGNVAKK 383
C F F++L+E+A V N P+ V A + K +A + N A
Sbjct: 326 CFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTN-ANL 384
Query: 384 NTVNGTGTPVHIST-----LQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSN---- 434
N T VH + +VG K + + S + S P F +N
Sbjct: 385 NMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQESSKGTPRSYLASSPNPFSRANAAET 444
Query: 435 -------------------------------YDCYGKPIE----VNNGLGKSQAKNNKKP 459
+G ++ N +G + + P
Sbjct: 445 ISAARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPP 504
Query: 460 PPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
P A P + +ID YAR LFP F FN++YW +YL
Sbjct: 505 PSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYL 542
>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
sapiens]
Length = 440
Score = 218 bits (555), Expect = 1e-56
Identities = 139/438 (31%), Positives = 228/438 (52%), Gaps = 46/438 (10%)
Query: 63 LLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDF 122
L Y+ +RPNF G PV + + + I S SI E+ MDY I+LRQ+W D RL F
Sbjct: 44 LTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLV----F 99
Query: 123 RGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLS 182
G+ + T+D + + LW PD + K + H+VT N L+ +F +G VL ++R++ T++
Sbjct: 100 EGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVA 159
Query: 183 CPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSG-DPVQ-LEKIALPQFDIKKEDIEY 240
C +DL+ +PMDTQ CK+QLES+GY +D+ F W G D V+ LE + L Q+ I++ +
Sbjct: 160 CNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIER---YF 216
Query: 241 GNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVP 300
T+ + TG YT + + F LRR V ++++ Y P+ +VVLSW+SFWI+ D+ AR
Sbjct: 217 TLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTC 276
Query: 301 LGIFSVLSLASECTTLAAELPKVS-YVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKR 359
+G+ +VLS+ + LP + ++KA+DV+L C F F +L+EYAV
Sbjct: 277 IGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVA--------H 328
Query: 360 VEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSND 419
+ + AK + V+ N +N + IS+ + +K+ + ++ S++
Sbjct: 329 YSSLQQMAAKDRGTTKEVEEVSITNIINSS-----ISSFK------RKISFASIEISSDN 377
Query: 420 FSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARA 479
D + D + +G+ + P +D Y++
Sbjct: 378 VDY-----SDLTMKTSDKF--KFVFREKMGRIVDYFTIQNP----------SNVDHYSKL 420
Query: 480 LFPFCFLFFNVIYWSIYL 497
LFP F+ NV YW+ Y+
Sbjct: 421 LFPLIFMLANVFYWAYYM 438
>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
precursor [Homo sapiens]
Length = 467
Score = 217 bits (553), Expect = 2e-56
Identities = 151/499 (30%), Positives = 230/499 (46%), Gaps = 62/499 (12%)
Query: 5 LTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLL 64
+T L+L+SL+ K + K ++ +VP + ILN LL
Sbjct: 23 MTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTP--------KVPEGDVTVILNNLL 74
Query: 65 VSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRG 124
YD ++RP+ P + ++++NS G + M+Y ++IF Q W D RLK S +
Sbjct: 75 EGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIK- 133
Query: 125 SDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCP 184
L ++ M +W PD FF N K A+ H +T N +L I+ DG VL ++RL+I C
Sbjct: 134 --VLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQ 191
Query: 185 LDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQ--SGDPVQLEKIALPQFDIKKEDIEYGN 242
L L FPMD C ++ S+GY +++ + W+ S + L QF + N
Sbjct: 192 LQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSF----VGLRN 247
Query: 243 CTKYYKGT-GYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPL 301
T+ K T G Y + V F L R++G++ + Y P LIVVLSW+SFWIN DA AR L
Sbjct: 248 TTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSL 307
Query: 302 GIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVE 361
GI +VL++ + T LPKVSYV A+D+++ C +F F++LVEY + ++N K
Sbjct: 308 GITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRK--- 364
Query: 362 AEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHIST---LQVGETRCKKVCTSKSDLRSN 418
++ D K N A + + ++ LQ + C D S
Sbjct: 365 -------PSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCAS- 416
Query: 419 DFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYAR 478
F DC ++ A + + I ++D YAR
Sbjct: 417 -----------FFCCFEDC------------RTGAWRHGR-------IHIRIAKMDSYAR 446
Query: 479 ALFPFCFLFFNVIYWSIYL 497
FP F FN++YW YL
Sbjct: 447 IFFPTAFCLFNLVYWVSYL 465
>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
sapiens]
Length = 451
Score = 214 bits (546), Expect = 1e-55
Identities = 144/462 (31%), Positives = 229/462 (49%), Gaps = 62/462 (13%)
Query: 46 EDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNI 105
ED A+ + IL+RLL YD R+RP +V NI++ SFG + +T M+Y +++
Sbjct: 32 EDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDV 91
Query: 106 FLRQKWNDPRLKLPSDFRGS-DALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLF 164
F RQKW D RLK F+G + L ++ M +W PD FF N K + H++T N LL
Sbjct: 92 FFRQKWKDERLK----FKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLR 147
Query: 165 IFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIW--QSGDPVQ 222
I DG +L +MRL++ CP+ L FPMD C ++ S+ YTT ++ +IW + D VQ
Sbjct: 148 IQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQ 207
Query: 223 L--EKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLI 280
+ + L Q+D+ + I G T TG YT + F L+R++G++++ Y P ++
Sbjct: 208 VAPDGSRLNQYDLLGQSI--GKET-IKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMT 264
Query: 281 VVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFG 340
V+LS +SFW+N ++ AR G+ +VL++ + + LPKV+Y A+D ++ C F
Sbjct: 265 VILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFV 324
Query: 341 FASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQV 400
F++L+E+A V +G K+ VN
Sbjct: 325 FSALIEFATVNYFTK--------------------RGWAWDGKSVVND------------ 352
Query: 401 GETRCKKVCTSKSDLRSNDFSI-----VGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKN 455
KK + +++N +++ +L +D LS E N K
Sbjct: 353 -----KKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNK-------KP 400
Query: 456 NKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
KP AK + +K ID +R +FP F FN++YW+ YL
Sbjct: 401 ENKPAEAKKTFNSVSK-IDRMSRIVFPVLFGTFNLVYWATYL 441
>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
[Homo sapiens]
Length = 451
Score = 214 bits (546), Expect = 1e-55
Identities = 144/462 (31%), Positives = 229/462 (49%), Gaps = 62/462 (13%)
Query: 46 EDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNI 105
ED A+ + IL+RLL YD R+RP +V NI++ SFG + +T M+Y +++
Sbjct: 32 EDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDV 91
Query: 106 FLRQKWNDPRLKLPSDFRGS-DALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLF 164
F RQKW D RLK F+G + L ++ M +W PD FF N K + H++T N LL
Sbjct: 92 FFRQKWKDERLK----FKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLR 147
Query: 165 IFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIW--QSGDPVQ 222
I DG +L +MRL++ CP+ L FPMD C ++ S+ YTT ++ +IW + D VQ
Sbjct: 148 IQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQ 207
Query: 223 L--EKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLI 280
+ + L Q+D+ + I G T TG YT + F L+R++G++++ Y P ++
Sbjct: 208 VAPDGSRLNQYDLLGQSI--GKET-IKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMT 264
Query: 281 VVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFG 340
V+LS +SFW+N ++ AR G+ +VL++ + + LPKV+Y A+D ++ C F
Sbjct: 265 VILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFV 324
Query: 341 FASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQV 400
F++L+E+A V +G K+ VN
Sbjct: 325 FSALIEFATVNYFTK--------------------RGWAWDGKSVVND------------ 352
Query: 401 GETRCKKVCTSKSDLRSNDFSI-----VGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKN 455
KK + +++N +++ +L +D LS E N K
Sbjct: 353 -----KKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNK-------KP 400
Query: 456 NKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
KP AK + +K ID +R +FP F FN++YW+ YL
Sbjct: 401 ENKPAEAKKTFNSVSK-IDRMSRIVFPVLFGTFNLVYWATYL 441
>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
precursor [Homo sapiens]
Length = 475
Score = 211 bits (538), Expect = 9e-55
Identities = 124/357 (34%), Positives = 188/357 (52%), Gaps = 18/357 (5%)
Query: 5 LTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLL 64
+T L+L+SL+ K + K ++ +VP + ILN LL
Sbjct: 23 MTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTP--------KVPEGDVTVILNNLL 74
Query: 65 VSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRG 124
YD ++RP+ P + ++++NS G + M+Y ++IF Q W D RLK S +
Sbjct: 75 EGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIK- 133
Query: 125 SDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCP 184
L ++ M +W PD FF N K A+ H +T N +L I+ DG VL ++RL+I C
Sbjct: 134 --VLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQ 191
Query: 185 LDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQ--SGDPVQLEKIALPQFDIKKEDIEYGN 242
L L FPMD C ++ S+GY +++ + W+ S + L QF + N
Sbjct: 192 LQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSF----VGLRN 247
Query: 243 CTKYYKGT-GYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPL 301
T+ K T G Y + V F L R++G++ + Y P LIVVLSW+SFWIN DA AR L
Sbjct: 248 TTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSL 307
Query: 302 GIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPK 358
GI +VL++ + T LPKVSYV A+D+++ C +F F++LVEY + ++N K
Sbjct: 308 GITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRK 364
Score = 35.0 bits (79), Expect = 0.16
Identities = 13/26 (50%), Positives = 17/26 (65%)
Query: 472 RIDLYARALFPFCFLFFNVIYWSIYL 497
++D YAR FP F FN++YW YL
Sbjct: 448 KMDSYARIFFPTAFCLFNLVYWVSYL 473
>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 207 bits (526), Expect = 2e-53
Identities = 133/462 (28%), Positives = 218/462 (47%), Gaps = 52/462 (11%)
Query: 42 QQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDY 101
Q S +D + + IL+RLL YD R+RP +V +IF+ SFG + + M+Y
Sbjct: 28 QPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEY 87
Query: 102 RVNIFLRQKWNDPRLKLPSDFRGS-DALTVDPTMYKCLWKPDLFFANEKSANFHDVTQEN 160
+++F RQ W D RLK F+G L ++ M +W PD FF N K + H++T N
Sbjct: 88 TIDVFFRQSWKDERLK----FKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPN 143
Query: 161 ILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDP 220
LL I DG +L +MRL++ CP+ L FPMD C ++ S+ YT ++ + W + +P
Sbjct: 144 KLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEW-TREP 202
Query: 221 VQLEKIA-----LPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYA 275
+ +A L Q+D+ + ++ G TG Y + F L+R++G++++ Y
Sbjct: 203 ARSVVVAEDGSRLNQYDLLGQTVDSGIVQS---STGEYVVMTTHFHLKRKIGYFVIQTYL 259
Query: 276 PTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIA 335
P ++ V+LS +SFW+N ++ AR G+ +VL++ + + LPKV+Y A+D ++
Sbjct: 260 PCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAV 319
Query: 336 CLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHI 395
C F F++L+E+A V KR A + E+ + KKN +
Sbjct: 320 CYAFVFSALIEFATVNYF---TKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYT 376
Query: 396 STLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKN 455
L G+ + S + + + K
Sbjct: 377 PNLARGDPGLATIAKSAT----------------------------------IEPKEVKP 402
Query: 456 NKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
KPP K + +K ID +R FP F FN++YW+ YL
Sbjct: 403 ETKPPEPKKTFNSVSK-IDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 207 bits (526), Expect = 2e-53
Identities = 133/462 (28%), Positives = 218/462 (47%), Gaps = 52/462 (11%)
Query: 42 QQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDY 101
Q S +D + + IL+RLL YD R+RP +V +IF+ SFG + + M+Y
Sbjct: 28 QPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEY 87
Query: 102 RVNIFLRQKWNDPRLKLPSDFRGS-DALTVDPTMYKCLWKPDLFFANEKSANFHDVTQEN 160
+++F RQ W D RLK F+G L ++ M +W PD FF N K + H++T N
Sbjct: 88 TIDVFFRQSWKDERLK----FKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPN 143
Query: 161 ILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDP 220
LL I DG +L +MRL++ CP+ L FPMD C ++ S+ YT ++ + W + +P
Sbjct: 144 KLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEW-TREP 202
Query: 221 VQLEKIA-----LPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYA 275
+ +A L Q+D+ + ++ G TG Y + F L+R++G++++ Y
Sbjct: 203 ARSVVVAEDGSRLNQYDLLGQTVDSGIVQS---STGEYVVMTTHFHLKRKIGYFVIQTYL 259
Query: 276 PTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIA 335
P ++ V+LS +SFW+N ++ AR G+ +VL++ + + LPKV+Y A+D ++
Sbjct: 260 PCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAV 319
Query: 336 CLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHI 395
C F F++L+E+A V KR A + E+ + KKN +
Sbjct: 320 CYAFVFSALIEFATVNYF---TKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYT 376
Query: 396 STLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKN 455
L G+ + S + + + K
Sbjct: 377 PNLARGDPGLATIAKSAT----------------------------------IEPKEVKP 402
Query: 456 NKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
KPP K + +K ID +R FP F FN++YW+ YL
Sbjct: 403 ETKPPEPKKTFNSVSK-IDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 207 bits (526), Expect = 2e-53
Identities = 133/462 (28%), Positives = 218/462 (47%), Gaps = 52/462 (11%)
Query: 42 QQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDY 101
Q S +D + + IL+RLL YD R+RP +V +IF+ SFG + + M+Y
Sbjct: 28 QPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEY 87
Query: 102 RVNIFLRQKWNDPRLKLPSDFRGS-DALTVDPTMYKCLWKPDLFFANEKSANFHDVTQEN 160
+++F RQ W D RLK F+G L ++ M +W PD FF N K + H++T N
Sbjct: 88 TIDVFFRQSWKDERLK----FKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPN 143
Query: 161 ILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDP 220
LL I DG +L +MRL++ CP+ L FPMD C ++ S+ YT ++ + W + +P
Sbjct: 144 KLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEW-TREP 202
Query: 221 VQLEKIA-----LPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYA 275
+ +A L Q+D+ + ++ G TG Y + F L+R++G++++ Y
Sbjct: 203 ARSVVVAEDGSRLNQYDLLGQTVDSGIVQS---STGEYVVMTTHFHLKRKIGYFVIQTYL 259
Query: 276 PTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIA 335
P ++ V+LS +SFW+N ++ AR G+ +VL++ + + LPKV+Y A+D ++
Sbjct: 260 PCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAV 319
Query: 336 CLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHI 395
C F F++L+E+A V KR A + E+ + KKN +
Sbjct: 320 CYAFVFSALIEFATVNYF---TKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYT 376
Query: 396 STLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKN 455
L G+ + S + + + K
Sbjct: 377 PNLARGDPGLATIAKSAT----------------------------------IEPKEVKP 402
Query: 456 NKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
KPP K + +K ID +R FP F FN++YW+ YL
Sbjct: 403 ETKPPEPKKTFNSVSK-IDRLSRIAFPLLFGIFNLVYWATYL 443
>gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 207 bits (526), Expect = 2e-53
Identities = 133/462 (28%), Positives = 218/462 (47%), Gaps = 52/462 (11%)
Query: 42 QQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDY 101
Q S +D + + IL+RLL YD R+RP +V +IF+ SFG + + M+Y
Sbjct: 28 QPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEY 87
Query: 102 RVNIFLRQKWNDPRLKLPSDFRGS-DALTVDPTMYKCLWKPDLFFANEKSANFHDVTQEN 160
+++F RQ W D RLK F+G L ++ M +W PD FF N K + H++T N
Sbjct: 88 TIDVFFRQSWKDERLK----FKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPN 143
Query: 161 ILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDP 220
LL I DG +L +MRL++ CP+ L FPMD C ++ S+ YT ++ + W + +P
Sbjct: 144 KLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEW-TREP 202
Query: 221 VQLEKIA-----LPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYA 275
+ +A L Q+D+ + ++ G TG Y + F L+R++G++++ Y
Sbjct: 203 ARSVVVAEDGSRLNQYDLLGQTVDSGIVQS---STGEYVVMTTHFHLKRKIGYFVIQTYL 259
Query: 276 PTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIA 335
P ++ V+LS +SFW+N ++ AR G+ +VL++ + + LPKV+Y A+D ++
Sbjct: 260 PCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAV 319
Query: 336 CLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHI 395
C F F++L+E+A V KR A + E+ + KKN +
Sbjct: 320 CYAFVFSALIEFATVNYF---TKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYT 376
Query: 396 STLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKN 455
L G+ + S + + + K
Sbjct: 377 PNLARGDPGLATIAKSAT----------------------------------IEPKEVKP 402
Query: 456 NKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL 497
KPP K + +K ID +R FP F FN++YW+ YL
Sbjct: 403 ETKPPEPKKTFNSVSK-IDRLSRIAFPLLFGIFNLVYWATYL 443
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,372,428
Number of Sequences: 37866
Number of extensions: 792837
Number of successful extensions: 2301
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2089
Number of HSP's gapped (non-prelim): 108
length of query: 497
length of database: 18,247,518
effective HSP length: 106
effective length of query: 391
effective length of database: 14,233,722
effective search space: 5565385302
effective search space used: 5565385302
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.