Search of human proteins with 4503875

Search of human proteins with 4503875

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503875 glutamate decarboxylase 2 [Homo sapiens]
         (585 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|197276620 glutamate decarboxylase 2 [Homo sapiens]                1207   0.0  
gi|4503875 glutamate decarboxylase 2 [Homo sapiens]                  1207   0.0  
gi|58331246 glutamate decarboxylase 1 isoform GAD67 [Homo sapiens]    783   0.0  
gi|194294551 cysteine sulfinic acid decarboxylase [Homo sapiens]      529   e-150
gi|197383062 glutamate decarboxylase-like 1 [Homo sapiens]            510   e-144
gi|15451889 glutamate decarboxylase 1 isoform GAD25 [Homo sapiens]    171   2e-42
gi|132814448 dopa decarboxylase (aromatic L-amino acid decarboxy...   139   9e-33
gi|4503281 dopa decarboxylase (aromatic L-amino acid decarboxyla...   139   9e-33
gi|92110055 histidine decarboxylase [Homo sapiens]                    123   4e-28
gi|190341074 pyridoxal-dependent decarboxylase domain containing...    47   6e-05
gi|31982936 sphingosine-1-phosphate lyase 1 [Homo sapiens]             40   0.005
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]        33   0.73 
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...    33   0.73 
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...    33   0.73 
gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo...    32   1.6  
gi|239750141 PREDICTED: similar to tripartite motif protein 39 [...    30   6.2  
gi|88953346 PREDICTED: Tripartite motif-containing protein 43-li...    30   6.2  
gi|148596992 heart alpha-kinase [Homo sapiens]                         30   6.2  
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...    30   6.2  
gi|20270353 tripartite motif-containing 43 [Homo sapiens]              30   6.2  
gi|12597655 centromere protein H [Homo sapiens]                        30   8.0  

>gi|197276620 glutamate decarboxylase 2 [Homo sapiens]
          Length = 585

 Score = 1207 bits (3124), Expect = 0.0
 Identities = 585/585 (100%), Positives = 585/585 (100%)

Query: 1   MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG 60
           MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG
Sbjct: 1   MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG 60

Query: 61  SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ 120
           SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ
Sbjct: 61  SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ 120

Query: 121 YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN 180
           YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN
Sbjct: 121 YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN 180

Query: 181 QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS 240
           QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS
Sbjct: 181 QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS 240

Query: 241 PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI 300
           PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI
Sbjct: 241 PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI 300

Query: 301 LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW 360
           LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW
Sbjct: 301 LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW 360

Query: 361 MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ 420
           MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ
Sbjct: 361 MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ 420

Query: 421 MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY 480
           MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY
Sbjct: 421 MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY 480

Query: 481 LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY 540
           LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY
Sbjct: 481 LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY 540

Query: 541 GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL 585
           GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL
Sbjct: 541 GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL 585


>gi|4503875 glutamate decarboxylase 2 [Homo sapiens]
          Length = 585

 Score = 1207 bits (3124), Expect = 0.0
 Identities = 585/585 (100%), Positives = 585/585 (100%)

Query: 1   MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG 60
           MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG
Sbjct: 1   MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG 60

Query: 61  SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ 120
           SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ
Sbjct: 61  SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ 120

Query: 121 YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN 180
           YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN
Sbjct: 121 YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN 180

Query: 181 QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS 240
           QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS
Sbjct: 181 QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS 240

Query: 241 PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI 300
           PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI
Sbjct: 241 PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI 300

Query: 301 LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW 360
           LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW
Sbjct: 301 LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW 360

Query: 361 MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ 420
           MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ
Sbjct: 361 MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ 420

Query: 421 MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY 480
           MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY
Sbjct: 421 MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY 480

Query: 481 LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY 540
           LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY
Sbjct: 481 LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY 540

Query: 541 GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL 585
           GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL
Sbjct: 541 GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL 585


>gi|58331246 glutamate decarboxylase 1 isoform GAD67 [Homo sapiens]
          Length = 594

 Score =  783 bits (2023), Expect = 0.0
 Identities = 375/569 (65%), Positives = 457/569 (80%), Gaps = 6/569 (1%)

Query: 23  PGTARAWCQVAQKFTGGIGNKLCALLYGD---AEKPAESGGSQPPRAAARKAACACDQKP 79
           P T   WC VA   T  +G K+C  L       EK       +  +++    +C    + 
Sbjct: 26  PTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCENSDRD 85

Query: 80  CSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPN 139
               + + +++ L A DLLPA +GE  T+ FL +V++ILL YV K+FDRSTKV+DFH+P+
Sbjct: 86  ARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPH 145

Query: 140 ELLQE---YNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWL 196
           +LL+    +N EL+D P++LE+IL+ C+ TLKY ++TGHPR+FNQLSTGLD++GLA +WL
Sbjct: 146 QLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWL 205

Query: 197 TSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARF 256
           TSTANTNMFTYEIAPVFVL+E +TLKKMREI+GW    GDGIFSPGGAISNMY++M AR+
Sbjct: 206 TSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARY 265

Query: 257 KMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLE 316
           K FPEVK KGMAA+P+L+ FTSE SH+S+KK  AALG GTD+VILIKC+ERGK+IP+D E
Sbjct: 266 KYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFE 325

Query: 317 RRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRK 376
            +ILEAKQKG+VPF V+ATAGTTVYGAFDP+  +ADIC+KY +W+HVDAAWGGGLLMSRK
Sbjct: 326 AKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRK 385

Query: 377 HKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLS 436
           H+ KL+G+ERANSVTWNPHKMMGV LQCSA+LV+E+G++Q CNQM A YLFQ DK YD+S
Sbjct: 386 HRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVS 445

Query: 437 YDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFD 496
           YDTGDKA+QCGRHVD+FK WLMW+AKGT GFE  ++KCLELAEYLY  IKNRE +EMVF+
Sbjct: 446 YDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFN 505

Query: 497 GKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNF 556
           G+P+HTNVCFWYIP SLR + D+ +R  +L KVAP IKA MME GTTMV YQP GDK NF
Sbjct: 506 GEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANF 565

Query: 557 FRMVISNPAATHQDIDFLIEEIERLGQDL 585
           FRMVISNPAAT  DIDFLIEEIERLGQDL
Sbjct: 566 FRMVISNPAATQSDIDFLIEEIERLGQDL 594


>gi|194294551 cysteine sulfinic acid decarboxylase [Homo sapiens]
          Length = 520

 Score =  529 bits (1363), Expect = e-150
 Identities = 254/494 (51%), Positives = 361/494 (73%), Gaps = 7/494 (1%)

Query: 95  TDLLPACDGERPTL-AFLQDVMNILLQYVV-KSFDRSTKVIDFHYPNELLQEYNWELADQ 152
           ++ LP+  G+   + A L+ V  +++   + K    S KV ++  P EL Q  + EL  Q
Sbjct: 31  SEALPSLAGDPVAVEALLRAVFGVVVDEAIQKGTSVSQKVCEWKEPEELKQLLDLELRSQ 90

Query: 153 PQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPV 212
            ++ ++IL  C+  ++Y++KTGHPR+FNQL +GLD   LA   +T + NT+ +TYEIAPV
Sbjct: 91  GESQKQILERCRAVIRYSVKTGHPRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPV 150

Query: 213 FVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPR 272
           FVL+E   L+K+R ++GW   SGDGIF PGG+ISNMYA+ +AR++ +P+ K++G+  LP 
Sbjct: 151 FVLMEEEVLRKLRALVGW--SSGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPP 208

Query: 273 LIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLV 332
           L  FTS+  H+S++KGAA LG+GTDSV ++K DERGKM+P DLER+I  A+ +G VPFLV
Sbjct: 209 LALFTSKECHYSIQKGAAFLGLGTDSVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLV 268

Query: 333 SATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTW 392
           SAT+GTTV GAFDPL A+AD+C+++ +W+HVDAAWGG +L+S+ H+  L G++RA+SV W
Sbjct: 269 SATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAW 328

Query: 393 NPHKMMGVPLQCSALLVRE-EGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVD 451
           NPHK++   LQCSALL+++   L++ C+   ASYLFQQDK YD++ DTGDK +QCGR VD
Sbjct: 329 NPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKFYDVALDTGDKVVQCGRRVD 388

Query: 452 VFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYIPP 511
             KLWLMW+A+G  G E  +D+   LA YL   +K REG+E+V +  P+  NVCFW++PP
Sbjct: 389 CLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVME--PEFVNVCFWFVPP 446

Query: 512 SLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDI 571
           SLR  +++ +   RLSKVAPV+K RM++ G+ M+ YQP G + NFFR+V++N A T  D+
Sbjct: 447 SLRGKQESPDYHERLSKVAPVLKERMVKEGSMMIGYQPHGTRGNFFRVVVANSALTCADM 506

Query: 572 DFLIEEIERLGQDL 585
           DFL+ E+ERLGQDL
Sbjct: 507 DFLLNELERLGQDL 520


>gi|197383062 glutamate decarboxylase-like 1 [Homo sapiens]
          Length = 521

 Score =  510 bits (1313), Expect = e-144
 Identities = 238/478 (49%), Positives = 346/478 (72%), Gaps = 6/478 (1%)

Query: 110 FLQDVMNILLQYVV-KSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLK 168
           F+++   ++++ VV K+ D + KV ++  P +L Q  + E+ D  +   ++L  C+  + 
Sbjct: 48  FVEEACRLIMEEVVLKATDVNEKVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELCRDVIH 107

Query: 169 YAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREII 228
           Y++KT HPR+FNQL  GLD   L A ++T   N +++TYE++PVF+L+E   LKKM E I
Sbjct: 108 YSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLKKMIEFI 167

Query: 229 GWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKG 288
           GW    GDGIF+PGG++SNMYAM +AR+K  P++KEKG++  PRLI FTS   H+S+KK 
Sbjct: 168 GWK--EGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSGSPRLILFTSAECHYSMKKA 225

Query: 289 AAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLL 348
           A+ LGIGT++V  ++ D RGKMIP +LE+++ +A+++G  PFLV AT+GTTV GAFDPL 
Sbjct: 226 ASFLGIGTENVCFVETDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPLD 285

Query: 349 AVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALL 408
            +ADIC+++ +W+HVDA+WGG  LMSRKH+  L G+ RA+SV WNPHKM+   +QC ALL
Sbjct: 286 EIADICERHSLWLHVDASWGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCALL 345

Query: 409 VREEG-LMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGF 467
           V+++  L++ C    ASYLFQQDK YD+SYDTGDK++QC R  D FK W+ W+A GT G 
Sbjct: 346 VKDKSDLLKKCYSAKASYLFQQDKFYDVSYDTGDKSIQCSRRPDAFKFWMTWKALGTLGL 405

Query: 468 EAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLS 527
           E  V++ L L+ YL + IK REG++++ +  P++ N+CFWYIPPSLR +E+  E  ++L+
Sbjct: 406 EERVNRALALSRYLVDEIKKREGFKLLME--PEYANICFWYIPPSLREMEEGPEFWAKLN 463

Query: 528 KVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL 585
            VAP IK RMM+ G+ M+ YQP   KVNFFR V+ +P  + +D+DFL++EI+ LG+D+
Sbjct: 464 LVAPAIKERMMKKGSLMLGYQPHRGKVNFFRQVVISPQVSREDMDFLLDEIDLLGKDM 521


>gi|15451889 glutamate decarboxylase 1 isoform GAD25 [Homo sapiens]
          Length = 224

 Score =  171 bits (433), Expect = 2e-42
 Identities = 87/188 (46%), Positives = 124/188 (65%), Gaps = 6/188 (3%)

Query: 23  PGTARAWCQVAQKFTGGIGNKLCALLYGD---AEKPAESGGSQPPRAAARKAACACDQKP 79
           P T   WC VA   T  +G K+C  L       EK       +  +++    +C    + 
Sbjct: 26  PTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCENSDRD 85

Query: 80  CSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPN 139
               + + +++ L A DLLPA +GE  T+ FL +V++ILL YV K+FDRSTKV+DFH+P+
Sbjct: 86  ARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPH 145

Query: 140 ELLQE---YNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWL 196
           +LL+    +N EL+D P++LE+IL+ C+ TLKY ++TGHPR+FNQLSTGLD++GLA +WL
Sbjct: 146 QLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWL 205

Query: 197 TSTANTNM 204
           TSTANTNM
Sbjct: 206 TSTANTNM 213


>gi|132814448 dopa decarboxylase (aromatic L-amino acid
           decarboxylase) [Homo sapiens]
          Length = 480

 Score =  139 bits (349), Expect = 9e-33
 Identities = 93/357 (26%), Positives = 167/357 (46%), Gaps = 20/357 (5%)

Query: 152 QPQNLEEILMHCQTTLKYAIKTGH-PRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIA 210
           +P   E+I+   +  +   +   H P +F    T      + AD L        F++  +
Sbjct: 49  EPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAAS 108

Query: 211 PVFVLLEYVTLKKMREIIGWP-------GGSGDGIFSPGGAISNMYAMMIARFKMF---- 259
           P    LE V +  + +++  P        G G G+     + + + A++ AR K+     
Sbjct: 109 PACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQ 168

Query: 260 ---PEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLE 316
              PE+ +   A + +L+A++S+ +H S+++      IG   +  I  D    M  S L+
Sbjct: 169 AASPELTQA--AIMEKLVAYSSDQAHSSVERAGL---IGGVKLKAIPSDGNFAMRASALQ 223

Query: 317 RRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRK 376
             +   K  G +PF + AT GTT   +FD LL V  IC K  IW+HVDAA+ G   +  +
Sbjct: 224 EALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPE 283

Query: 377 HKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLS 436
            +  L+GVE A+S  +NPHK + V   CSA+ V++   +    ++  +YL    +   L 
Sbjct: 284 FRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLI 343

Query: 437 YDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEM 493
            D     +  GR     K+W ++R  G  G +A++ K ++L+    ++++    +E+
Sbjct: 344 TDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEI 400


>gi|4503281 dopa decarboxylase (aromatic L-amino acid decarboxylase)
           [Homo sapiens]
          Length = 480

 Score =  139 bits (349), Expect = 9e-33
 Identities = 93/357 (26%), Positives = 167/357 (46%), Gaps = 20/357 (5%)

Query: 152 QPQNLEEILMHCQTTLKYAIKTGH-PRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIA 210
           +P   E+I+   +  +   +   H P +F    T      + AD L        F++  +
Sbjct: 49  EPDTFEDIINDVEKIIMPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAAS 108

Query: 211 PVFVLLEYVTLKKMREIIGWP-------GGSGDGIFSPGGAISNMYAMMIARFKMF---- 259
           P    LE V +  + +++  P        G G G+     + + + A++ AR K+     
Sbjct: 109 PACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLVALLAARTKVIHRLQ 168

Query: 260 ---PEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLE 316
              PE+ +   A + +L+A++S+ +H S+++      IG   +  I  D    M  S L+
Sbjct: 169 AASPELTQA--AIMEKLVAYSSDQAHSSVERAGL---IGGVKLKAIPSDGNFAMRASALQ 223

Query: 317 RRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRK 376
             +   K  G +PF + AT GTT   +FD LL V  IC K  IW+HVDAA+ G   +  +
Sbjct: 224 EALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPE 283

Query: 377 HKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLS 436
            +  L+GVE A+S  +NPHK + V   CSA+ V++   +    ++  +YL    +   L 
Sbjct: 284 FRHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLI 343

Query: 437 YDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEM 493
            D     +  GR     K+W ++R  G  G +A++ K ++L+    ++++    +E+
Sbjct: 344 TDYRHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEI 400


>gi|92110055 histidine decarboxylase [Homo sapiens]
          Length = 662

 Score =  123 bits (309), Expect = 4e-28
 Identities = 86/316 (27%), Positives = 147/316 (46%), Gaps = 18/316 (5%)

Query: 191 LAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWP--------GGSGDGIFSPG 242
           L  D L    N   FT+  +P    LE   +  + +++G P           G G+    
Sbjct: 90  LLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQST 149

Query: 243 GAISNMYAMMIARFKMFPEVKEKGMAA-----LPRLIAFTSEHSHFSLKKGAAALGIGTD 297
            + S + A++ AR     E+K     A       RL+A+ S+ +H S++K      I   
Sbjct: 150 VSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSSVEKAGL---ISLV 206

Query: 298 SVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKY 357
            +  +  D+   +    L++ I E KQ+G VP  V AT GTT   AFD L  +  IC + 
Sbjct: 207 KMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICARE 266

Query: 358 KIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQN 417
            +W+H+DAA+ G   +  + +  L G+E A+S T+NP K M V   C+   V+++  +Q 
Sbjct: 267 GLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQ 326

Query: 418 CNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLEL 477
              ++  YL  +  +  ++ D     +   R     KLW + R+ G    +AHV    E+
Sbjct: 327 TFSVNPIYL--RHANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEM 384

Query: 478 AEYLYNIIKNREGYEM 493
           A+Y  ++++N   +E+
Sbjct: 385 AKYFESLVRNDPSFEI 400


>gi|190341074 pyridoxal-dependent decarboxylase domain containing 1
           [Homo sapiens]
          Length = 788

 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 26/98 (26%), Positives = 50/98 (51%), Gaps = 1/98 (1%)

Query: 315 LERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMS 374
           LE+ I +  ++G +P L+ A AGT   G  D +  + ++C++Y IW+HV+      L + 
Sbjct: 221 LEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALG 280

Query: 375 RKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREE 412
                 L+   + +S+T  P   +G+P   +  L + +
Sbjct: 281 YVSSSVLAAA-KCDSMTMTPGPWLGLPAVPAVTLYKHD 317


>gi|31982936 sphingosine-1-phosphate lyase 1 [Homo sapiens]
          Length = 568

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 43/142 (30%), Positives = 62/142 (43%), Gaps = 16/142 (11%)

Query: 232 GGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAA 291
           G    G  + GG  S + A    R   F    EKG+   P ++A  S H+ F+  K A+ 
Sbjct: 199 GPDSCGCVTSGGTESILMACKAYRDLAF----EKGIKT-PEIVAPQSAHAAFN--KAASY 251

Query: 292 LGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVA 351
            G+    V L K  E        ++ R +          LV +T     +G  DP+  VA
Sbjct: 252 FGMKIVRVPLTKMME--------VDVRAMRRAISRNTAMLVCSTPQFP-HGVIDPVPEVA 302

Query: 352 DICKKYKIWMHVDAAWGGGLLM 373
            +  KYKI +HVDA  GG L++
Sbjct: 303 KLAVKYKIPLHVDACLGGFLIV 324


>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
          Length = 535

 Score = 33.1 bits (74), Expect = 0.73
 Identities = 21/62 (33%), Positives = 32/62 (51%), Gaps = 4/62 (6%)

Query: 196 LTSTANTNMFTYE---IAPVFVLLEYVTLKKMREIIGW-PGGSGDGIFSPGGAISNMYAM 251
           + S    NM  Y+     PV V+LE  TL +  +I+   P G+G  IF+  GA +  YA 
Sbjct: 403 IISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAH 462

Query: 252 MI 253
           ++
Sbjct: 463 LV 464


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score = 33.1 bits (74), Expect = 0.73
 Identities = 25/77 (32%), Positives = 33/77 (42%), Gaps = 9/77 (11%)

Query: 9    WSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAA- 67
            W   +E GSG+   PG A+AW   A+   G    K  +      E PAE  GS  P AA 
Sbjct: 2148 WRPSAELGSGE---PGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAE 2204

Query: 68   -----ARKAACACDQKP 79
                  R+   +C+  P
Sbjct: 2205 GGSTTLRRRTPSCEATP 2221


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score = 33.1 bits (74), Expect = 0.73
 Identities = 25/77 (32%), Positives = 33/77 (42%), Gaps = 9/77 (11%)

Query: 9    WSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAA- 67
            W   +E GSG+   PG A+AW   A+   G    K  +      E PAE  GS  P AA 
Sbjct: 2154 WRPSAELGSGE---PGEAKAWGPEAEPALGARRKKKMSPPCISVEPPAEDEGSARPSAAE 2210

Query: 68   -----ARKAACACDQKP 79
                  R+   +C+  P
Sbjct: 2211 GGSTTLRRRTPSCEATP 2227


>gi|227430338 SH3 domain containing, Ysc84-like 1 isoform 2 [Homo
           sapiens]
          Length = 323

 Score = 32.0 bits (71), Expect = 1.6
 Identities = 25/90 (27%), Positives = 39/90 (43%), Gaps = 4/90 (4%)

Query: 380 KLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ---MHASYLFQQDKHYDLS 436
           K +  +R +S    P K +  P Q SA +    G   N NQ   + A Y F+  +  DL+
Sbjct: 225 KAAREQRKSSAKELPPKPLSRPQQSSAPVQLNSGSQSNLNQPIEVTALYSFEGQQPGDLN 284

Query: 437 YDTGDKALQCGRHVDVFKLWLMWRAKGTTG 466
           +  GD+     +    F  W   + +G TG
Sbjct: 285 FQAGDRITVISKTDSHFD-WWEGKLRGQTG 313


>gi|239750141 PREDICTED: similar to tripartite motif protein 39
           [Homo sapiens]
          Length = 229

 Score = 30.0 bits (66), Expect = 6.2
 Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 10/71 (14%)

Query: 365 AAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHAS 424
           AAWG  +  S KH W+L   +  NS  W     +GV   C    +R+   M N   +   
Sbjct: 108 AAWGAWVFSSGKHYWEL---DVDNSWDW----ALGV---CKDSWIRKNSTMFNSKDIFLL 157

Query: 425 YLFQQDKHYDL 435
              + D H+ L
Sbjct: 158 LCVKVDNHFSL 168


>gi|88953346 PREDICTED: Tripartite motif-containing protein 43-like
           protein 1 [Homo sapiens]
          Length = 446

 Score = 30.0 bits (66), Expect = 6.2
 Identities = 20/71 (28%), Positives = 31/71 (43%), Gaps = 10/71 (14%)

Query: 365 AAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHAS 424
           AAWG  +    KH W+L   +  NS  W     +GV   C+   +R+   M N   +   
Sbjct: 325 AAWGARVFSFGKHYWEL---DVDNSCDW----ALGV---CNNSWIRKNSTMVNSEDIFLL 374

Query: 425 YLFQQDKHYDL 435
              + D H++L
Sbjct: 375 LCLKVDNHFNL 385


>gi|148596992 heart alpha-kinase [Homo sapiens]
          Length = 2170

 Score = 30.0 bits (66), Expect = 6.2
 Identities = 19/70 (27%), Positives = 30/70 (42%), Gaps = 2/70 (2%)

Query: 17  SGDSENPGTARAWCQVAQKFTGG--IGNKLCALLYGDAEKPAESGGSQPPRAAARKAACA 74
           SG+SEN G ++ W   A K  GG  + +K  +       +P   G  + P A  R++   
Sbjct: 500 SGESENSGMSQCWETAADKRVGGKDLWSKRGSRKSARVRQPGMKGNPKKPNANLRESTTE 559

Query: 75  CDQKPCSCSK 84
                CS  +
Sbjct: 560 GTLHLCSAKE 569


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score = 30.0 bits (66), Expect = 6.2
 Identities = 17/64 (26%), Positives = 30/64 (46%), Gaps = 1/64 (1%)

Query: 340 VYGAFDPLLAVADICKKY-KIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMM 398
           + G FD  +A+ D+ + Y K+ +     W   + +S   KW LS  +      WN  ++ 
Sbjct: 337 ISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEID 396

Query: 399 GVPL 402
            +PL
Sbjct: 397 EIPL 400


>gi|20270353 tripartite motif-containing 43 [Homo sapiens]
          Length = 446

 Score = 30.0 bits (66), Expect = 6.2
 Identities = 20/71 (28%), Positives = 31/71 (43%), Gaps = 10/71 (14%)

Query: 365 AAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHAS 424
           AAWG  +    KH W+L   +  NS  W     +GV   C+   +R+   M N   +   
Sbjct: 325 AAWGARVFSFGKHYWEL---DVDNSCDW----ALGV---CNNSWIRKNSTMVNSEDIFLL 374

Query: 425 YLFQQDKHYDL 435
              + D H++L
Sbjct: 375 LCLKVDNHFNL 385


>gi|12597655 centromere protein H [Homo sapiens]
          Length = 247

 Score = 29.6 bits (65), Expect = 8.0
 Identities = 14/31 (45%), Positives = 21/31 (67%), Gaps = 4/31 (12%)

Query: 51 DAEKPAESGGSQ----PPRAAARKAACACDQ 77
          DA++PA+SGG      PP+ A  +AAC+ D+
Sbjct: 9  DADEPADSGGEGRAGGPPQVAGAQAACSEDR 39


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,294,663
Number of Sequences: 37866
Number of extensions: 1065926
Number of successful extensions: 2441
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2416
Number of HSP's gapped (non-prelim): 22
length of query: 585
length of database: 18,247,518
effective HSP length: 108
effective length of query: 477
effective length of database: 14,157,990
effective search space: 6753361230
effective search space used: 6753361230
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.