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Search of human proteins with 4503865
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
(474 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 956 0.0
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 937 0.0
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 772 0.0
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 763 0.0
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 752 0.0
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur... 370 e-102
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre... 342 4e-94
gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom... 322 6e-88
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec... 315 6e-86
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s... 309 4e-84
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom... 305 5e-83
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 293 3e-79
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 292 4e-79
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo... 289 4e-78
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] 288 6e-78
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] 288 6e-78
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens] 288 7e-78
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens] 288 7e-78
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo... 285 5e-77
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens] 284 1e-76
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso... 281 9e-76
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ... 280 2e-75
gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens] 280 2e-75
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s... 279 3e-75
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs... 279 3e-75
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor... 276 4e-74
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 275 9e-74
gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 275 9e-74
gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 275 9e-74
gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 275 9e-74
>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
Length = 474
Score = 956 bits (2470), Expect = 0.0
Identities = 474/474 (100%), Positives = 474/474 (100%)
Query: 1 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV 60
MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV
Sbjct: 1 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV 60
Query: 61 AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT 120
AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT
Sbjct: 61 AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT 120
Query: 121 YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES 180
YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES
Sbjct: 121 YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES 180
Query: 181 YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR 240
YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR
Sbjct: 181 YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR 240
Query: 241 NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP 300
NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP
Sbjct: 241 NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP 300
Query: 301 YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKM 360
YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKM
Sbjct: 301 YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKM 360
Query: 361 DPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALER 420
DPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALER
Sbjct: 361 DPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALER 420
Query: 421 HVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474
HVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
Sbjct: 421 HVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474
>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 1 [Homo sapiens]
Length = 512
Score = 937 bits (2421), Expect = 0.0
Identities = 474/512 (92%), Positives = 474/512 (92%), Gaps = 38/512 (7%)
Query: 1 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV 60
MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV
Sbjct: 1 MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV 60
Query: 61 AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT 120
AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT
Sbjct: 61 AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT 120
Query: 121 YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES 180
YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES
Sbjct: 121 YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES 180
Query: 181 YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR 240
YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR
Sbjct: 181 YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR 240
Query: 241 NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP 300
NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP
Sbjct: 241 NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP 300
Query: 301 YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK- 359
YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK
Sbjct: 301 YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKI 360
Query: 360 -------------------------------------MDPHENILLSTLEIKNEMATSEA 382
MDPHENILLSTLEIKNEMATSEA
Sbjct: 361 FYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEA 420
Query: 383 VMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD 442
VMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD
Sbjct: 421 VMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD 480
Query: 443 LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474
LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
Sbjct: 481 LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 512
>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 1 precursor [Homo sapiens]
Length = 473
Score = 772 bits (1994), Expect = 0.0
Identities = 379/475 (79%), Positives = 420/475 (88%), Gaps = 3/475 (0%)
Query: 1 MWRVRKRGYFGIWSFPLIIAAVC-AQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP 59
MW + FGI+S P+++A VC AQSVNDP NMS VKETVD+LLKGYDIRLRPDFGGPP
Sbjct: 1 MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP 60
Query: 60 VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD 119
V VGMNIDIASIDMVSEVNMDYTLTMYFQQ WRDKRL+Y+ IPLNLTLDNRVADQLWVPD
Sbjct: 61 VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD 120
Query: 120 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 179
TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
Sbjct: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180
Query: 180 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK 239
SYGYTTDDIEFYWRG D AVTGV +IELPQFSIV+++L+++ VVF+TG+YPRLSLSF+LK
Sbjct: 181 SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK 240
Query: 240 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299
RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI
Sbjct: 241 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 300
Query: 300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK 359
PYVKAIDMYLMGCFVFVF+ALLEYA VNYIFFGRGPQRQKK AEK A A N++ + + N+
Sbjct: 301 PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR 360
Query: 360 MDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALE 419
+D H NILL++LE+ NEM +E G+GD R++ +++D S IQYRK +PR GR +
Sbjct: 361 VDAHGNILLTSLEVHNEM--NEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGD 418
Query: 420 RHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474
R + KK+ LRRR+SQLKI IPDLTDVNAIDRWSRI FP FS FN+VYWLYYVN
Sbjct: 419 RSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473
>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
Length = 474
Score = 763 bits (1969), Expect = 0.0
Identities = 376/477 (78%), Positives = 421/477 (88%), Gaps = 6/477 (1%)
Query: 1 MWRVRKRGYFGIWSFPLIIAAVC-AQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPP 59
MW V+ R G+ SFP++I VC A S N+PSNMS VKETVDRLLKGYDIRLRPDFGGPP
Sbjct: 1 MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP 60
Query: 60 VAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPD 119
V VGM ID+ASIDMVSEVNMDYTLTMYFQQ+W+DKRLSY+ IPLNLTLDNRVADQLWVPD
Sbjct: 61 VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD 120
Query: 120 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 179
TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
Sbjct: 121 TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE 180
Query: 180 SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLK 239
SYGYTTDDIEFYW G + AVTGV KIELPQFSIVDYK+++KKV F+TG+YPRLSLSF+LK
Sbjct: 181 SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK 240
Query: 240 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299
RNIGYFILQTYMPS LITILSWVSFWINYDASAARVALGITTVLTMTTI+THLRETLPKI
Sbjct: 241 RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI 300
Query: 300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK 359
PYVKAID+YLMGCFVFVF+ALLEYA VNYIFFG+GP QKK A K + NEK +L++NK
Sbjct: 301 PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGP--QKKGASKQDQSANEKNKLEMNK 358
Query: 360 --MDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNA 417
+D H NILLSTLEI+NE + SE + + DP++TM +YD++SIQYRK R ++GR A
Sbjct: 359 VQVDAHGNILLSTLEIRNETSGSEVLTSVSDPKATMYSYDSASIQYRKPLSSREAYGR-A 417
Query: 418 LERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474
L+RH K R+RRRASQLK+ IPDLTDVN+ID+WSR+FFP+ FS FN+VYWLYYV+
Sbjct: 418 LDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH 474
>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
Length = 473
Score = 752 bits (1942), Expect = 0.0
Identities = 367/450 (81%), Positives = 404/450 (89%), Gaps = 2/450 (0%)
Query: 25 QSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLT 84
+SVNDP NMS VKETVD+LLKGYDIRLRPDFGGPPV VGMNIDIASIDMVSEVNMDYTLT
Sbjct: 26 RSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLT 85
Query: 85 MYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP 144
MYFQQ WRDKRL+Y+ IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP
Sbjct: 86 MYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHP 145
Query: 145 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTK 204
DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRG D AVTGV +
Sbjct: 146 DGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVER 205
Query: 205 IELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSF 264
IELPQFSIV+++L+++ VVF+TG+YPRLSLSF+LKRNIGYFILQTYMPSILITILSWVSF
Sbjct: 206 IELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSF 265
Query: 265 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYA 324
WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVF+ALLEYA
Sbjct: 266 WINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYA 325
Query: 325 LVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVM 384
VNYIFFGRGPQRQKK AEK A A N++ + + N++D H NILL++LE+ NEM +E
Sbjct: 326 FVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEM--NEVSG 383
Query: 385 GLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLT 444
G+GD R++ +++D S IQYRK +PR GR +R + KK+ LRRR+SQLKI IPDLT
Sbjct: 384 GIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLT 443
Query: 445 DVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474
DVNAIDRWSRI FP FS FN+VYWLYYVN
Sbjct: 444 DVNAIDRWSRIVFPFTFSLFNLVYWLYYVN 473
>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
[Homo sapiens]
Length = 632
Score = 370 bits (950), Expect = e-102
Identities = 162/310 (52%), Positives = 239/310 (77%)
Query: 31 SNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQA 90
+N ++V++ +DR+L YD+RLRP+FGG PV V ++I + SI+ +SE+NMDYT+TM+F Q
Sbjct: 54 ANEAVVQKILDRVLSRYDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQT 113
Query: 91 WRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLY 150
W+D RL+Y LNLTLD R+ ++LWVPD YFLN K +FVH VTV+NR+ +LHPDGTV Y
Sbjct: 114 WKDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRY 173
Query: 151 GLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQF 210
G+R+TTTAAC +DL ++P+D+Q C L +ESYGYT +DI +W + NA+ ++ +PQF
Sbjct: 174 GIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQF 233
Query: 211 SIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDA 270
+ + + +K+V F TGSY RL L F+++R + +++Q Y P++L TI SW+SFW+NYD+
Sbjct: 234 TFLGRTITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDS 293
Query: 271 SAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIF 330
SAARV +G+T++L +TTI++HLR+ LP I +KAID+Y++ C FVF++LLEY +NY+F
Sbjct: 294 SAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLF 353
Query: 331 FGRGPQRQKK 340
+ RGP+RQ +
Sbjct: 354 YSRGPRRQPR 363
Score = 43.5 bits (101), Expect = 4e-04
Identities = 15/28 (53%), Positives = 21/28 (75%)
Query: 446 VNAIDRWSRIFFPVVFSFFNIVYWLYYV 473
V +D+WSR FP+ F FNIVYW+Y++
Sbjct: 604 VPKVDKWSRFLFPLAFGLFNIVYWVYHM 631
>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
precursor [Homo sapiens]
Length = 452
Score = 342 bits (877), Expect = 4e-94
Identities = 183/437 (41%), Positives = 263/437 (60%), Gaps = 34/437 (7%)
Query: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
+D L+ GY RP GGPPV V + +++ASID +SE NM+YT+T++ Q+WRD RLSYN
Sbjct: 44 LDGLIAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYN 103
Query: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
L LD+R D+LW+PDT+ +N K ++ H VTV+N++IRL PDG +LY +RIT+T A
Sbjct: 104 HTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVA 163
Query: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLIT 219
C MDL +YP+DEQ C L++ESYGY+++DI +YW + G+ K++L QF+I Y+ T
Sbjct: 164 CDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTT 223
Query: 220 KKVVF-STGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALG 278
+ + F S G +PRLSL F L+RN G +I+Q+YMPS+L+ +SWVSFWI+ A ARV+LG
Sbjct: 224 ELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLG 283
Query: 279 ITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQ 338
ITTVLTMTT+ R +LP+ +KA+D+Y C+VFVF AL+EYA + F +++
Sbjct: 284 ITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYA---FAHFNADYRKK 340
Query: 339 KKAAEKAASANNEKMRLDVNKMDPHENILLSTLE---IKNEMATSEAVMGLGDPRSTMLA 395
+KA K + E MD I+L +L + E+A S + P + M +
Sbjct: 341 QKAKVKVSRPRAE--------MDVRNAIVLFSLSAAGVTQELAISRRQRRV--PGNLMGS 390
Query: 396 YDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRI 455
YR G+ + R Q R R R D + ID ++R
Sbjct: 391 -------YRSVGVETGETKKEGAARSGGQGGIRARLRP----------IDADTIDIYARA 433
Query: 456 FFPVVFSFFNIVYWLYY 472
FP F+ N++YW Y
Sbjct: 434 VFPAAFAAVNVIYWAAY 450
>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
sapiens]
Length = 479
Score = 322 bits (824), Expect = 6e-88
Identities = 174/428 (40%), Positives = 260/428 (60%), Gaps = 41/428 (9%)
Query: 47 YDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSY-NVIPLNL 105
+D +RP FGGP + VG+++ + S+D +SEV+MD+T+T+Y + W+D+RLS+ + L++
Sbjct: 84 HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143
Query: 106 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 165
T D R+ ++WVPD +F++ K+SF+H T N M+R+ PDG VLY LR+T TA C MD
Sbjct: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203
Query: 166 RYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVF- 224
R+PLD Q C+LEIESY YT DD+ YW+ ++++ +I L QF I ++ TK +
Sbjct: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263
Query: 225 STGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 284
STG Y RL ++F L+R+I +F+LQTY P+ L+ +LSWVSFWI+ A ARV LGITTVLT
Sbjct: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323
Query: 285 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEK 344
M+TI T + ++P++ Y+KA+D+YL FVFVF+++LEYA VNY+ + + QK +
Sbjct: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKL 383
Query: 345 AASANNEKMR---LDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSI 401
++ R LD N D N L + + E P M+ +S
Sbjct: 384 PCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGE-----------KPDRMMVQLTLAS- 431
Query: 402 QYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVF 461
ER Q+KS +R+S + + I D +AID++SRI FP +
Sbjct: 432 -----------------ERSSPQRKS---QRSSYVSMRI----DTHAIDKYSRIIFPAAY 467
Query: 462 SFFNIVYW 469
FN++YW
Sbjct: 468 ILFNLIYW 475
>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
precursor [Homo sapiens]
Length = 490
Score = 315 bits (807), Expect = 6e-86
Identities = 171/429 (39%), Positives = 262/429 (61%), Gaps = 37/429 (8%)
Query: 47 YDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIP-LNL 105
+D +RP FGGP + VG+++ + S+D +SEV+MD+T+T+Y + W+D+RL+++ ++
Sbjct: 89 HDFSMRPAFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSM 148
Query: 106 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 165
T D R+ ++WVPD +F++ K+SF H T N M+R+ PDG VLY +RIT TA C MD
Sbjct: 149 TFDGRLVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFS 208
Query: 166 RYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFS 225
+PLD Q C+LE+ESY YT +D+ YW+ D ++ KI L QF I + ++ +S
Sbjct: 209 HFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYS 268
Query: 226 -TGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 284
TG Y RL ++F L+R+I +F+LQTY P+ L+ +LSWVSFWI+ A ARV+LGITTVLT
Sbjct: 269 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLT 328
Query: 285 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEK 344
MTTI T + ++P++ YVKA+D+YL FVFVF+++LEYA VNY+ + ++++K EK
Sbjct: 329 MTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQ-ERKERKLREK 387
Query: 345 ----AASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASS 400
+++ M LD + SEA G PRS +L +
Sbjct: 388 FPCMCGMLHSKTMMLD------------------GSYSESEANSLAGYPRSHILTEEE-- 427
Query: 401 IQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVV 460
R+ + H G + E + A+KK L+ + + +AID++SR+ FP
Sbjct: 428 ---RQDKIVVH-LGLSG-EANAARKKGLLKGQTG-----FRIFQNTHAIDKYSRLIFPAS 477
Query: 461 FSFFNIVYW 469
+ FFN++YW
Sbjct: 478 YIFFNLIYW 486
>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
sapiens]
Length = 440
Score = 309 bits (791), Expect = 4e-84
Identities = 170/434 (39%), Positives = 251/434 (57%), Gaps = 38/434 (8%)
Query: 41 DRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNV 100
+ L GY+ LRP+FGG PV + + +DIASI +SE NMDYT T+Y +Q W D+RL +
Sbjct: 42 ENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG 101
Query: 101 IPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC 160
+ TLD R+ + LWVPDTY + KKSF+H VTV NR+IRL +GTVLY LRITTT AC
Sbjct: 102 NK-SFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVAC 160
Query: 161 MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITK 220
MDL +YP+D Q C L++ES+GY +D+EF W +++V G+ + L Q++I Y +
Sbjct: 161 NMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT 220
Query: 221 KVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGIT 280
+ TG+Y RL L F+L+RN+ YFIL+TY+PS + +LSWVSFWI+ D+ AR +G+T
Sbjct: 221 RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVT 280
Query: 281 TVLTMTTINTHLRETLPKIP-YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQK 339
TVL+MTT+ R +LP ++KAID+YL CF FVF ALLEYA+ +Y +Q
Sbjct: 281 TVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHY-----SSLQQM 335
Query: 340 KAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDAS 399
A ++ + E++ + NI+ S++ S +
Sbjct: 336 AAKDRGTTKEVEEVSI--------TNIINSSIS------------------SFKRKISFA 369
Query: 400 SIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPV 459
SI+ + ++ + ++ R I P + +D +S++ FP+
Sbjct: 370 SIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNP-----SNVDHYSKLLFPL 424
Query: 460 VFSFFNIVYWLYYV 473
+F N+ YW YY+
Sbjct: 425 IFMLANVFYWAYYM 438
>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
sapiens]
Length = 467
Score = 305 bits (782), Expect = 5e-83
Identities = 169/431 (39%), Positives = 259/431 (60%), Gaps = 39/431 (9%)
Query: 48 DIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSY-NVIPLNLT 106
D +RP FGG PV VG+++ + SID +SE NMD+T+T Y + W+D+RLS+ + ++T
Sbjct: 71 DFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMT 130
Query: 107 LDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRR 166
D+R+ ++WVPD +F++ K+SF+H T++N M+R+HPDG VL LRIT +A C MD R
Sbjct: 131 FDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190
Query: 167 YPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVF-S 225
+PLD QNC+LE+ESY Y DD+ YW+ + ++ + L QF I D+ + + S
Sbjct: 191 FPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSS 250
Query: 226 TGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTM 285
TG Y RL ++F L+R++ +F+LQTY P+IL+ +LSWVSFWI+ A ARV+LGITTVLTM
Sbjct: 251 TGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTM 310
Query: 286 TTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKA 345
+TI T + ++P++ Y+KA+D+YL +FVF++++EYA VNY+ ++ KK + +
Sbjct: 311 STIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKIS 370
Query: 346 ASAN---NEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQ 402
N + M D D ++ ++L + +E + P + D+S I+
Sbjct: 371 RMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRR--KSICSPST-----DSSRIK 423
Query: 403 YRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFS 462
RK+ L H GR LE + + ID +SRI FP+V+
Sbjct: 424 RRKS-LGGH-VGRIILENN-------------------------HVIDTYSRILFPIVYI 456
Query: 463 FFNIVYWLYYV 473
FN+ YW YV
Sbjct: 457 LFNLFYWGVYV 467
>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
precursor [Homo sapiens]
Length = 475
Score = 293 bits (749), Expect = 3e-79
Identities = 165/449 (36%), Positives = 248/449 (55%), Gaps = 60/449 (13%)
Query: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL +N
Sbjct: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
Query: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
Query: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLIT 219
C + L +P+DE +C LE SYGY ++I + W+ V L QFS V + T
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249
Query: 220 KKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 279
+ V ++G Y +S+ F L R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGI
Sbjct: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309
Query: 280 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQK 339
TTVLTMTT++T R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y R P + K
Sbjct: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK 369
Query: 340 KAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRS-TMLAYDA 398
+K N +R+ K T++I+ PRS T+ +A
Sbjct: 370 DKKKK-----NPLLRMFSFK--------APTIDIR--------------PRSATIQMNNA 402
Query: 399 SSIQYRKAGLPRHSFGRNALE--------------RHVAQKKSRLRRRASQLKITIPDLT 444
+ +Q R +G L+ R A + R+ R +++
Sbjct: 403 THLQERD-----EEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKM-------- 449
Query: 445 DVNAIDRWSRIFFPVVFSFFNIVYWLYYV 473
D ++RIFFP F FN+VYW+ Y+
Sbjct: 450 -----DSYARIFFPTAFCLFNLVYWVSYL 473
>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
precursor [Homo sapiens]
Length = 467
Score = 292 bits (748), Expect = 4e-79
Identities = 159/434 (36%), Positives = 239/434 (55%), Gaps = 38/434 (8%)
Query: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
++ LL+GYD +LRPD G P + ++ + SI V+ +NM+YT+ ++F Q W D+RL +N
Sbjct: 70 LNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFN 129
Query: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
L L++ + ++W+PDT+F N KK+ H +T NRM+R+ DG VLY LR+T A
Sbjct: 130 STIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAE 189
Query: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLIT 219
C + L +P+DE +C LE SYGY ++I + W+ V L QFS V + T
Sbjct: 190 CQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTT 249
Query: 220 KKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 279
+ V ++G Y +S+ F L R +GYF +QTY+P LI +LSWVSFWIN DA AR +LGI
Sbjct: 250 EVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGI 309
Query: 280 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQK 339
TTVLTMTT++T R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y R P + K
Sbjct: 310 TTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK 369
Query: 340 KAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDAS 399
+K N +D+ +T+++ N E R Y+
Sbjct: 370 DKKKK-----NPAPTIDIRPRS-------ATIQMNNATHLQE--------RDEEYGYECL 409
Query: 400 SIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPV 459
+ + R RH R+ R +++ D ++RIFFP
Sbjct: 410 DGKDCASFFCCFEDCRTGAWRH-----GRIHIRIAKM-------------DSYARIFFPT 451
Query: 460 VFSFFNIVYWLYYV 473
F FN+VYW+ Y+
Sbjct: 452 AFCLFNLVYWVSYL 465
>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 457
Score = 289 bits (739), Expect = 4e-78
Identities = 177/458 (38%), Positives = 255/458 (55%), Gaps = 43/458 (9%)
Query: 21 AVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMD 80
A A+S P + S + + GYD R+RP+F GPPV V NI I S ++E MD
Sbjct: 26 AEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMD 85
Query: 81 YTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 139
Y + ++ +Q W D RL+YN P + L LD + D +W PD +F N+K + H +T N++
Sbjct: 86 YRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKL 145
Query: 140 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAV 199
+R+ +G VLY +RIT T AC MDL+ +P+D Q C +++ES+GYT +D+ F W+ + AV
Sbjct: 146 LRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQ-EQGAV 204
Query: 200 TGVTKIELPQFSIV---DYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILI 256
+ LPQF + D + TK ++TG + + F L+R +GY+++Q Y+PS+LI
Sbjct: 205 QVADGLTLPQFILKEEKDLRYCTKH--YNTGKFTCIEARFHLERQMGYYLIQMYIPSLLI 262
Query: 257 TILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFV 316
ILSW+SFWIN DA+ ARV LGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FV
Sbjct: 263 VILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFV 322
Query: 317 FMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNE 376
F ALLEYA VN++ RQ K E +R K H++ +L N
Sbjct: 323 FSALLEYAAVNFV------SRQHK----------ELLRFR-RKRRHHKSPML------NL 359
Query: 377 MATSEAVMGLGDPRSTMLAY--DASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRAS 434
EA G+ R AY + +Q + + + N A KS R
Sbjct: 360 FQEDEA----GEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMR-- 413
Query: 435 QLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
K+ I ID+ SRI FP+ F FN+ YW+ Y
Sbjct: 414 --KLFI---QRAKKIDKISRIGFPMAFLIFNMFYWIIY 446
>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 288 bits (738), Expect = 6e-78
Identities = 172/457 (37%), Positives = 258/457 (56%), Gaps = 55/457 (12%)
Query: 24 AQSVNDPSNMSLVKETVDRLL---KGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMD 80
++S PS + +D+L+ GYD R+RP+F GPPV V NI I S V+E MD
Sbjct: 32 SRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMD 91
Query: 81 YTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 139
Y + ++ +Q W D RL+Y+ P + L LD + D +W PD +F N+K + H VT N++
Sbjct: 92 YRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKL 151
Query: 140 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAV 199
+R+ +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W D V
Sbjct: 152 LRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSD-GPV 210
Query: 200 TGVTKIELPQFSIVDYKLI---TKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILI 256
+ LPQF + + K + TK ++TG + + + F L+R +GY+++Q Y+PS+LI
Sbjct: 211 QVAEGLTLPQFILKEEKELGYCTKH--YNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLI 268
Query: 257 TILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFV 316
ILSWVSFWIN DA+ ARVALGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FV
Sbjct: 269 VILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFV 328
Query: 317 FMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNE 376
F ALLEYA VN++ RQ K E +RL + +N ++ E
Sbjct: 329 FAALLEYAAVNFV------SRQHK----------EFLRL--RRRQKRQN---KEEDVTRE 367
Query: 377 MATSEAVMGLGDPRSTMLAYDASSIQYRKAG-LPRHSFGRNALERHVAQKKSRLRRRASQ 435
+ + G+G + D ++++ A LP+ +A+++ + R
Sbjct: 368 SRFNFSGYGMG---HCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKR------- 417
Query: 436 LKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
ID SR FP+ F FNI YW+ Y
Sbjct: 418 -------------IDTISRAAFPLAFLIFNIFYWITY 441
>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 288 bits (738), Expect = 6e-78
Identities = 172/457 (37%), Positives = 258/457 (56%), Gaps = 55/457 (12%)
Query: 24 AQSVNDPSNMSLVKETVDRLL---KGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMD 80
++S PS + +D+L+ GYD R+RP+F GPPV V NI I S V+E MD
Sbjct: 32 SRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMD 91
Query: 81 YTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 139
Y + ++ +Q W D RL+Y+ P + L LD + D +W PD +F N+K + H VT N++
Sbjct: 92 YRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKL 151
Query: 140 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAV 199
+R+ +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W D V
Sbjct: 152 LRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSD-GPV 210
Query: 200 TGVTKIELPQFSIVDYKLI---TKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILI 256
+ LPQF + + K + TK ++TG + + + F L+R +GY+++Q Y+PS+LI
Sbjct: 211 QVAEGLTLPQFILKEEKELGYCTKH--YNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLI 268
Query: 257 TILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFV 316
ILSWVSFWIN DA+ ARVALGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FV
Sbjct: 269 VILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFV 328
Query: 317 FMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNE 376
F ALLEYA VN++ RQ K E +RL + +N ++ E
Sbjct: 329 FAALLEYAAVNFV------SRQHK----------EFLRL--RRRQKRQN---KEEDVTRE 367
Query: 377 MATSEAVMGLGDPRSTMLAYDASSIQYRKAG-LPRHSFGRNALERHVAQKKSRLRRRASQ 435
+ + G+G + D ++++ A LP+ +A+++ + R
Sbjct: 368 SRFNFSGYGMG---HCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKR------- 417
Query: 436 LKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
ID SR FP+ F FNI YW+ Y
Sbjct: 418 -------------IDTISRAAFPLAFLIFNIFYWITY 441
>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
Length = 452
Score = 288 bits (737), Expect = 7e-78
Identities = 171/457 (37%), Positives = 258/457 (56%), Gaps = 55/457 (12%)
Query: 24 AQSVNDPSNMSLVKETVDRLL---KGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMD 80
++S PS + +D+L+ GYD R+RP+F GPPV V NI I S ++E MD
Sbjct: 32 SRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMD 91
Query: 81 YTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 139
Y + ++ +Q W D RL+Y+ P + L LD + D +W PD +F N+K + H VT N++
Sbjct: 92 YRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKL 151
Query: 140 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAV 199
+R+ +G VLY +R+T T +C MDL+ +P+D Q CT+++ES+GYT +D+ F W D V
Sbjct: 152 LRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSD-GPV 210
Query: 200 TGVTKIELPQFSIVDYKLI---TKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILI 256
+ LPQF + + K + TK ++TG + + + F L+R +GY+++Q Y+PS+LI
Sbjct: 211 QVAEGLTLPQFILKEEKELGYCTKH--YNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLI 268
Query: 257 TILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFV 316
ILSWVSFWIN DA+ ARVALGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FV
Sbjct: 269 VILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFV 328
Query: 317 FMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNE 376
F ALLEYA VN++ RQ K E +RL + +N ++ E
Sbjct: 329 FAALLEYAAVNFV------SRQHK----------EFLRL--RRRQKRQN---KEEDVTRE 367
Query: 377 MATSEAVMGLGDPRSTMLAYDASSIQYRKAG-LPRHSFGRNALERHVAQKKSRLRRRASQ 435
+ + G+G + D ++++ A LP+ +A+++ + R
Sbjct: 368 SRFNFSGYGMG---HCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKR------- 417
Query: 436 LKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
ID SR FP+ F FNI YW+ Y
Sbjct: 418 -------------IDTISRAAFPLAFLIFNIFYWITY 441
>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
Length = 464
Score = 288 bits (737), Expect = 7e-78
Identities = 174/474 (36%), Positives = 259/474 (54%), Gaps = 47/474 (9%)
Query: 10 FGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLK------GYDIRLRPDFGGPPVAVG 63
F W L+++ V + + + S D L K GYD R+RP+F GPPV V
Sbjct: 14 FYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVT 73
Query: 64 MNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTYF 122
NI I S ++E MDY + ++ +Q W D RL+Y+ P + L LD + D +W PD +F
Sbjct: 74 CNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFF 133
Query: 123 LNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYG 182
N+K + H VT N+++R+ +G VLY +R+T T +C MDL+ +P+D Q C +++ES+G
Sbjct: 134 ANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFG 193
Query: 183 YTTDDIEFYWRGDDNAVTGVTKIELPQFSIV---DYKLITKKVVFSTGSYPRLSLSFKLK 239
YT +D+ F W+ D+ V + LPQF + D + TK ++TG + + + F L+
Sbjct: 194 YTMNDLIFEWQ-DEAPVQVAEGLTLPQFLLKEEKDLRYCTKH--YNTGKFTCIEVRFHLE 250
Query: 240 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299
R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ ARVALGITTVLTMTT ++ R +LPK+
Sbjct: 251 RQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKV 310
Query: 300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK 359
YVKAID+++ C +FVF ALLEYA VN++ RQ K E +R +
Sbjct: 311 SYVKAIDIWMAVCLLFVFSALLEYAAVNFV------SRQHK----------ELLRFRRKR 354
Query: 360 MDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGL-PRHSFGRNAL 418
+ E L ++M + + R + AY K G+ P+ G N
Sbjct: 355 KNKTEAFALEKFYRFSDMDDE-----VRESRFSFTAYGMGPCLQAKDGMTPK---GPNHP 406
Query: 419 ERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
+ + + +R+ + ID SR FP+ F FNI YW+ Y
Sbjct: 407 VQVMPKSPDEMRK---------VFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 451
>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
sapiens]
Length = 449
Score = 285 bits (730), Expect = 5e-77
Identities = 170/461 (36%), Positives = 249/461 (54%), Gaps = 57/461 (12%)
Query: 21 AVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMD 80
A A+S P + S + + GYD R+RP+F GPPV V NI I S ++E MD
Sbjct: 26 AEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMD 85
Query: 81 YTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 139
Y + ++ +Q W D RL+YN P + L LD + D +W PD +F N+K + H +T N++
Sbjct: 86 YRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKL 145
Query: 140 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAV 199
+R+ +G VLY +RIT T AC MDL+ +P+D Q C +++ES+GYT +D+ F W+ + AV
Sbjct: 146 LRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQ-EQGAV 204
Query: 200 TGVTKIELPQFSIV---DYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILI 256
+ LPQF + D + TK ++TG + + F L+R +GY+++Q Y+PS+LI
Sbjct: 205 QVADGLTLPQFILKEEKDLRYCTKH--YNTGKFTCIEARFHLERQMGYYLIQMYIPSLLI 262
Query: 257 TILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFV 316
ILSW+SFWIN DA+ ARV LGITTVLTMTT ++ R +LPK+ YVKAID+++ C +FV
Sbjct: 263 VILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFV 322
Query: 317 FMALLEYALVNYIFFGRGPQ---RQKKAAEKAASANNEKMRLDVNKMDPHENILLSTLEI 373
F ALLEYA VN++ R+K+ K A + M P + L+
Sbjct: 323 FSALLEYAAVNFVSRQHKELLRFRRKRRHHKEDEAGEGRFNFSAYGMGP------ACLQA 376
Query: 374 KNEMATSEAVMGLGDPRST--MLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRR 431
K+ + +V G + +T A S + RK + R
Sbjct: 377 KDGI----SVKGANNSNTTNPPPAPSKSPEEMRKLFIQR--------------------- 411
Query: 432 RASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
ID+ SRI FP+ F FN+ YW+ Y
Sbjct: 412 --------------AKKIDKISRIGFPMAFLIFNMFYWIIY 438
>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
Length = 449
Score = 284 bits (726), Expect = 1e-76
Identities = 171/473 (36%), Positives = 255/473 (53%), Gaps = 60/473 (12%)
Query: 10 FGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLK------GYDIRLRPDFGGPPVAVG 63
F W L+++ V + + + S D L K GYD R+RP+F GPPV V
Sbjct: 14 FYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVT 73
Query: 64 MNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTYF 122
NI I S ++E MDY + ++ +Q W D RL+Y+ P + L LD + D +W PD +F
Sbjct: 74 CNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFF 133
Query: 123 LNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYG 182
N+K + H VT N+++R+ +G VLY +R+T T +C MDL+ +P+D Q C +++ES+G
Sbjct: 134 ANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFG 193
Query: 183 YTTDDIEFYWRGDDNAVTGVTKIELPQFSIV---DYKLITKKVVFSTGSYPRLSLSFKLK 239
YT +D+ F W+ D+ V + LPQF + D + TK ++TG + + + F L+
Sbjct: 194 YTMNDLIFEWQ-DEAPVQVAEGLTLPQFLLKEEKDLRYCTKH--YNTGKFTCIEVRFHLE 250
Query: 240 RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI 299
R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ ARVALGITTVLTMTT ++ R +LPK+
Sbjct: 251 RQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKV 310
Query: 300 PYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNK 359
YVKAID+++ C +FVF ALLEYA VN++ RQ K E +R +
Sbjct: 311 SYVKAIDIWMAVCLLFVFSALLEYAAVNFV------SRQHK----------ELLRFRRKR 354
Query: 360 MDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALE 419
+ + + E S G+G +Q + P+ G N
Sbjct: 355 KNKDDEV--------RESRFSFTAYGMG-----------PCLQAKDGMTPK---GPNHPV 392
Query: 420 RHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
+ + + +R+ + ID SR FP+ F FNI YW+ Y
Sbjct: 393 QVMPKSPDEMRK---------VFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 436
>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
[Homo sapiens]
Length = 465
Score = 281 bits (719), Expect = 9e-76
Identities = 155/439 (35%), Positives = 242/439 (55%), Gaps = 40/439 (9%)
Query: 36 VKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKR 95
+ + ++ LL+GYD +LRPD G P + ++ + SI V +NM+YT+ + F Q W D R
Sbjct: 64 ITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSR 123
Query: 96 LSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRIT 155
L +N L L++ + ++W+PDT+F N +KS H +T NR++R+ DG VLY LR+T
Sbjct: 124 LKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLT 183
Query: 156 TTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDY 215
A C + L +P+DE +C LE SYGY ++IE+ W+ V L QF+ V
Sbjct: 184 INAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGL 243
Query: 216 KLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARV 275
+ T+ +G Y +++ F L R +GYF +QTY+P IL +LSWVSFWIN DA AR
Sbjct: 244 RNSTEITHTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPART 303
Query: 276 ALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGP 335
+LGITTVLTMTT++T R++LPK+ YV A+D+++ CF+FVF AL+EY ++Y
Sbjct: 304 SLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYF------ 357
Query: 336 QRQKKAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLA 395
+ +K +A ++ ++KN+ + + + P ST++
Sbjct: 358 ----TSNQKGKTATKDR-------------------KLKNKASMTPGL----HPGSTLIP 390
Query: 396 YDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRR-RASQLKITIPDLTDVNAIDRWSR 454
+ S+ + G++ + R R ++ I I ID +SR
Sbjct: 391 MNNISVPQEDDYGYQCLEGKDCASFFCCFEDCRTGSWREGRIHIRIA------KIDSYSR 444
Query: 455 IFFPVVFSFFNIVYWLYYV 473
IFFP F+ FN+VYW+ Y+
Sbjct: 445 IFFPTAFALFNLVYWVGYL 463
>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
[Homo sapiens]
Length = 467
Score = 280 bits (716), Expect = 2e-75
Identities = 151/437 (34%), Positives = 243/437 (55%), Gaps = 25/437 (5%)
Query: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
+++LL+ YD +LRPD G P + ++I + SI VS +NM+Y + ++F Q W D RL +N
Sbjct: 51 LNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFN 110
Query: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
LTL++ + +W+PDT F N K + H +T N+++R+ DG +LY LR+T A
Sbjct: 111 STMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAE 170
Query: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLIT 219
C + L +P+DE +C L SYGY +++ + WR + L QF + + T
Sbjct: 171 CQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTT 230
Query: 220 KKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI 279
+ V S G Y +++ F+L R +GYF +QTY+P IL +LSWVSFWI DA+ AR ALGI
Sbjct: 231 EIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGI 290
Query: 280 TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQK 339
TTVLTMTT++T R++LP++ YV A+D+++ CF+FVF AL+EYA +NY R P K
Sbjct: 291 TTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTK 350
Query: 340 KAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDAS 399
K + D ++ P I + ++ +++ + P + M+ + S
Sbjct: 351 K--------TTSLLHPDSSRWIPE--------RISLQAPSNYSLLDMRPPPTAMITLNNS 394
Query: 400 SI--QYRKAGLPRHSFGRNALERHVAQKKSRLRR-RASQLKITIPDLTDVNAIDRWSRIF 456
++ + G++ ++ + R ++ I D+ +D +SR+F
Sbjct: 395 VYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKGRIHI------DILELDSYSRVF 448
Query: 457 FPVVFSFFNIVYWLYYV 473
FP F FN+VYW+ Y+
Sbjct: 449 FPTSFLLFNLVYWVGYL 465
>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
Length = 417
Score = 280 bits (716), Expect = 2e-75
Identities = 145/331 (43%), Positives = 210/331 (63%), Gaps = 15/331 (4%)
Query: 12 IWSFP---LIIAAVCAQSVNDPSNMSLVKETVDRLLK------GYDIRLRPDFGGPPVAV 62
+W+ P L+ A+ + V + S D L K GYD R+RP+F GPPV V
Sbjct: 14 LWTLPGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNV 73
Query: 63 GMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTY 121
NI I S +++ MDY + ++ +Q W D RLSY P + L LD + D +W PD +
Sbjct: 74 TCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLF 133
Query: 122 FLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESY 181
F N+K + H VT N+++R+ +G VLY +R+T +C+MDL+ +P+D Q CT+++ES+
Sbjct: 134 FANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESF 193
Query: 182 GYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLI---TKKVVFSTGSYPRLSLSFKL 238
GYT D+ F W D AV + LPQF + D K + TK ++TG + + + F L
Sbjct: 194 GYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCCTKH--YNTGKFTCIEVKFHL 251
Query: 239 KRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPK 298
+R +GY+++Q Y+PS+LI ILSWVSFWIN DA+ ARV LGITTVLTMTT ++ R +LPK
Sbjct: 252 ERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPK 311
Query: 299 IPYVKAIDMYLMGCFVFVFMALLEYALVNYI 329
+ YVKAID+++ C +FVF ALLEYA +N++
Sbjct: 312 VSYVKAIDIWMAVCLLFVFAALLEYAAINFV 342
>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
sapiens]
Length = 451
Score = 279 bits (714), Expect = 3e-75
Identities = 161/468 (34%), Positives = 250/468 (53%), Gaps = 45/468 (9%)
Query: 10 FGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIA 69
F +W P + Q +N+++ +DRLL GYD RLRP G V NI +
Sbjct: 17 FLVWD-PARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVT 75
Query: 70 SIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTYFLNDKKS 128
S VS+ +M+YT+ ++F+Q W+D+RL + P+N L L+N +A ++W PDT+F N KKS
Sbjct: 76 SFGPVSDTDMEYTIDVFFRQKWKDERLKFKG-PMNILRLNNLMASKIWTPDTFFHNGKKS 134
Query: 129 FVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDI 188
H +T+ N+++R+ DGT+LY +R+T A C M L +P+D +C L+ SY YTT ++
Sbjct: 135 VAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEV 194
Query: 189 EFYW--RGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFI 246
+ W D+ L Q+ ++ + + + STG Y ++ F LKR IGYF+
Sbjct: 195 TYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFV 254
Query: 247 LQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAID 306
+QTY+P I+ ILS VSFW+N ++ AR G+TTVLTMTT++ R +LPK+ Y A+D
Sbjct: 255 IQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMD 314
Query: 307 MYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKMDPHENI 366
++ C+ FVF AL+E+A VNY F RG A S N+K + + M +
Sbjct: 315 WFIAVCYAFVFSALIEFATVNY-FTKRG------WAWDGKSVVNDKKKEKASVMIQNNAY 367
Query: 367 LLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKK 426
++ ++ DP + ++ A++ + K
Sbjct: 368 AVAVANYAPNLSK--------DPVLSTISKSATTPEPNK--------------------- 398
Query: 427 SRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474
+ + ++ K T V+ IDR SRI FPV+F FN+VYW Y+N
Sbjct: 399 -KPENKPAEAKKT---FNSVSKIDRMSRIVFPVLFGTFNLVYWATYLN 442
>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
[Homo sapiens]
Length = 451
Score = 279 bits (714), Expect = 3e-75
Identities = 161/468 (34%), Positives = 250/468 (53%), Gaps = 45/468 (9%)
Query: 10 FGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIA 69
F +W P + Q +N+++ +DRLL GYD RLRP G V NI +
Sbjct: 17 FLVWD-PARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVT 75
Query: 70 SIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLN-LTLDNRVADQLWVPDTYFLNDKKS 128
S VS+ +M+YT+ ++F+Q W+D+RL + P+N L L+N +A ++W PDT+F N KKS
Sbjct: 76 SFGPVSDTDMEYTIDVFFRQKWKDERLKFKG-PMNILRLNNLMASKIWTPDTFFHNGKKS 134
Query: 129 FVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDI 188
H +T+ N+++R+ DGT+LY +R+T A C M L +P+D +C L+ SY YTT ++
Sbjct: 135 VAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEV 194
Query: 189 EFYW--RGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFI 246
+ W D+ L Q+ ++ + + + STG Y ++ F LKR IGYF+
Sbjct: 195 TYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFV 254
Query: 247 LQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAID 306
+QTY+P I+ ILS VSFW+N ++ AR G+TTVLTMTT++ R +LPK+ Y A+D
Sbjct: 255 IQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMD 314
Query: 307 MYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKMDPHENI 366
++ C+ FVF AL+E+A VNY F RG A S N+K + + M +
Sbjct: 315 WFIAVCYAFVFSALIEFATVNY-FTKRG------WAWDGKSVVNDKKKEKASVMIQNNAY 367
Query: 367 LLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKK 426
++ ++ DP + ++ A++ + K
Sbjct: 368 AVAVANYAPNLSK--------DPVLSTISKSATTPEPNK--------------------- 398
Query: 427 SRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 474
+ + ++ K T V+ IDR SRI FPV+F FN+VYW Y+N
Sbjct: 399 -KPENKPAEAKKT---FNSVSKIDRMSRIVFPVLFGTFNLVYWATYLN 442
>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
[Homo sapiens]
Length = 492
Score = 276 bits (705), Expect = 4e-74
Identities = 158/445 (35%), Positives = 239/445 (53%), Gaps = 29/445 (6%)
Query: 32 NMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAW 91
N+++ +DRLL GYD RLRP G V +I + S VS+ +M+YT+ ++F+Q W
Sbjct: 63 NITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTW 122
Query: 92 RDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYG 151
D+RL ++ L L+N +A ++W PDT+F N KKS H +T N+++RL +GT+LY
Sbjct: 123 HDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYT 182
Query: 152 LRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTK--IELPQ 209
+R+T A C M L +P+D C L+ SY YTT ++ + W N V + L Q
Sbjct: 183 MRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQ 242
Query: 210 FSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYD 269
+ ++ + + T+ + STG Y ++ F LKR IGYF++QTY+P I+ ILS VSFW+N +
Sbjct: 243 YDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRE 302
Query: 270 ASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYI 329
+ AR G+TTVLTMTT++ R +LPK+ Y A+D ++ C+ FVF AL+E+A VNY
Sbjct: 303 SVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNY- 361
Query: 330 FFGRGPQRQKKAAEKAASANNEKMRLDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDP 389
F R + K +A + K NI+ +T I
Sbjct: 362 FTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPIN--------------- 406
Query: 390 RSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAI 449
LA D K P S + + K + ++ ++ K V+ +
Sbjct: 407 ----LAKDTEFSTISKGAAPSASSTPTII---ASPKATYVQDSPTETK----TYNSVSKV 455
Query: 450 DRWSRIFFPVVFSFFNIVYWLYYVN 474
D+ SRI FPV+F+ FN+VYW YVN
Sbjct: 456 DKISRIIFPVLFAIFNLVYWATYVN 480
>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 275 bits (702), Expect = 9e-74
Identities = 163/482 (33%), Positives = 250/482 (51%), Gaps = 67/482 (13%)
Query: 12 IWSFPLIIAAVCAQSVNDPS-------NMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGM 64
+W++ L+++ + +S PS N ++ +DRLL GYD RLRP G V
Sbjct: 11 LWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKT 70
Query: 65 NIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLN 124
+I + S VS+ +M+YT+ ++F+Q+W+D+RL + L L+N +A ++W PDT+F N
Sbjct: 71 DIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHN 130
Query: 125 DKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYT 184
KKS H +T+ N+++R+ DGT+LY +R+T A C M L +P+D C L+ SY YT
Sbjct: 131 GKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYT 190
Query: 185 TDDIEFYWRGDD--NAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNI 242
++ + W + + V L Q+ ++ + + V STG Y ++ F LKR I
Sbjct: 191 RAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 243 GYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYV 302
GYF++QTY+P I+ ILS VSFW+N ++ AR G+TTVLTMTT++ R +LPK+ Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 303 KAIDMYLMGCFVFVFMALLEYALVNYIFFGRG---------PQRQKKAAEKAASANNEKM 353
A+D ++ C+ FVF AL+E+A VNY F RG P++ KK + NN
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNY-FTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYA 369
Query: 354 RLDVNKMDPHENILLSTLEIKNEMATSEAV-MGLGDPRSTMLAYDASSIQYRKAGLPRHS 412
ATS + GDP +A A+
Sbjct: 370 ----------------------PTATSYTPNLARGDPGLATIAKSAT------------- 394
Query: 413 FGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
+ K+ + + + K T V+ IDR SRI FP++F FN+VYW Y
Sbjct: 395 ---------IEPKEVKPETKPPEPKKT---FNSVSKIDRLSRIAFPLLFGIFNLVYWATY 442
Query: 473 VN 474
+N
Sbjct: 443 LN 444
>gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 275 bits (702), Expect = 9e-74
Identities = 163/482 (33%), Positives = 250/482 (51%), Gaps = 67/482 (13%)
Query: 12 IWSFPLIIAAVCAQSVNDPS-------NMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGM 64
+W++ L+++ + +S PS N ++ +DRLL GYD RLRP G V
Sbjct: 11 LWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKT 70
Query: 65 NIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLN 124
+I + S VS+ +M+YT+ ++F+Q+W+D+RL + L L+N +A ++W PDT+F N
Sbjct: 71 DIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHN 130
Query: 125 DKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYT 184
KKS H +T+ N+++R+ DGT+LY +R+T A C M L +P+D C L+ SY YT
Sbjct: 131 GKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYT 190
Query: 185 TDDIEFYWRGDD--NAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNI 242
++ + W + + V L Q+ ++ + + V STG Y ++ F LKR I
Sbjct: 191 RAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 243 GYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYV 302
GYF++QTY+P I+ ILS VSFW+N ++ AR G+TTVLTMTT++ R +LPK+ Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 303 KAIDMYLMGCFVFVFMALLEYALVNYIFFGRG---------PQRQKKAAEKAASANNEKM 353
A+D ++ C+ FVF AL+E+A VNY F RG P++ KK + NN
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNY-FTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYA 369
Query: 354 RLDVNKMDPHENILLSTLEIKNEMATSEAV-MGLGDPRSTMLAYDASSIQYRKAGLPRHS 412
ATS + GDP +A A+
Sbjct: 370 ----------------------PTATSYTPNLARGDPGLATIAKSAT------------- 394
Query: 413 FGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
+ K+ + + + K T V+ IDR SRI FP++F FN+VYW Y
Sbjct: 395 ---------IEPKEVKPETKPPEPKKT---FNSVSKIDRLSRIAFPLLFGIFNLVYWATY 442
Query: 473 VN 474
+N
Sbjct: 443 LN 444
>gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 275 bits (702), Expect = 9e-74
Identities = 163/482 (33%), Positives = 250/482 (51%), Gaps = 67/482 (13%)
Query: 12 IWSFPLIIAAVCAQSVNDPS-------NMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGM 64
+W++ L+++ + +S PS N ++ +DRLL GYD RLRP G V
Sbjct: 11 LWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKT 70
Query: 65 NIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLN 124
+I + S VS+ +M+YT+ ++F+Q+W+D+RL + L L+N +A ++W PDT+F N
Sbjct: 71 DIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHN 130
Query: 125 DKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYT 184
KKS H +T+ N+++R+ DGT+LY +R+T A C M L +P+D C L+ SY YT
Sbjct: 131 GKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYT 190
Query: 185 TDDIEFYWRGDD--NAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNI 242
++ + W + + V L Q+ ++ + + V STG Y ++ F LKR I
Sbjct: 191 RAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 243 GYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYV 302
GYF++QTY+P I+ ILS VSFW+N ++ AR G+TTVLTMTT++ R +LPK+ Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 303 KAIDMYLMGCFVFVFMALLEYALVNYIFFGRG---------PQRQKKAAEKAASANNEKM 353
A+D ++ C+ FVF AL+E+A VNY F RG P++ KK + NN
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNY-FTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYA 369
Query: 354 RLDVNKMDPHENILLSTLEIKNEMATSEAV-MGLGDPRSTMLAYDASSIQYRKAGLPRHS 412
ATS + GDP +A A+
Sbjct: 370 ----------------------PTATSYTPNLARGDPGLATIAKSAT------------- 394
Query: 413 FGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
+ K+ + + + K T V+ IDR SRI FP++F FN+VYW Y
Sbjct: 395 ---------IEPKEVKPETKPPEPKKT---FNSVSKIDRLSRIAFPLLFGIFNLVYWATY 442
Query: 473 VN 474
+N
Sbjct: 443 LN 444
>gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 275 bits (702), Expect = 9e-74
Identities = 163/482 (33%), Positives = 250/482 (51%), Gaps = 67/482 (13%)
Query: 12 IWSFPLIIAAVCAQSVNDPS-------NMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGM 64
+W++ L+++ + +S PS N ++ +DRLL GYD RLRP G V
Sbjct: 11 LWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKT 70
Query: 65 NIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLN 124
+I + S VS+ +M+YT+ ++F+Q+W+D+RL + L L+N +A ++W PDT+F N
Sbjct: 71 DIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHN 130
Query: 125 DKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYT 184
KKS H +T+ N+++R+ DGT+LY +R+T A C M L +P+D C L+ SY YT
Sbjct: 131 GKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYT 190
Query: 185 TDDIEFYWRGDD--NAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNI 242
++ + W + + V L Q+ ++ + + V STG Y ++ F LKR I
Sbjct: 191 RAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKI 250
Query: 243 GYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYV 302
GYF++QTY+P I+ ILS VSFW+N ++ AR G+TTVLTMTT++ R +LPK+ Y
Sbjct: 251 GYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310
Query: 303 KAIDMYLMGCFVFVFMALLEYALVNYIFFGRG---------PQRQKKAAEKAASANNEKM 353
A+D ++ C+ FVF AL+E+A VNY F RG P++ KK + NN
Sbjct: 311 TAMDWFIAVCYAFVFSALIEFATVNY-FTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYA 369
Query: 354 RLDVNKMDPHENILLSTLEIKNEMATSEAV-MGLGDPRSTMLAYDASSIQYRKAGLPRHS 412
ATS + GDP +A A+
Sbjct: 370 ----------------------PTATSYTPNLARGDPGLATIAKSAT------------- 394
Query: 413 FGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYY 472
+ K+ + + + K T V+ IDR SRI FP++F FN+VYW Y
Sbjct: 395 ---------IEPKEVKPETKPPEPKKT---FNSVSKIDRLSRIAFPLLFGIFNLVYWATY 442
Query: 473 VN 474
+N
Sbjct: 443 LN 444
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,871,756
Number of Sequences: 37866
Number of extensions: 610848
Number of successful extensions: 1871
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1694
Number of HSP's gapped (non-prelim): 108
length of query: 474
length of database: 18,247,518
effective HSP length: 106
effective length of query: 368
effective length of database: 14,233,722
effective search space: 5238009696
effective search space used: 5238009696
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.