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Search of human proteins with 4503743
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503743 flightless I homolog [Homo sapiens]
(1269 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503743 flightless I homolog [Homo sapiens] 2568 0.0
gi|162951877 scinderin isoform 1 [Homo sapiens] 280 8e-75
gi|17572824 advillin [Homo sapiens] 280 8e-75
gi|194394237 villin 1 [Homo sapiens] 270 6e-72
gi|4504165 gelsolin isoform a precursor [Homo sapiens] 259 1e-68
gi|38044288 gelsolin isoform b [Homo sapiens] 258 3e-68
gi|189083782 gelsolin isoform c [Homo sapiens] 258 3e-68
gi|189083780 gelsolin isoform c [Homo sapiens] 258 3e-68
gi|189083778 gelsolin isoform b [Homo sapiens] 258 3e-68
gi|189083776 gelsolin isoform b [Homo sapiens] 258 3e-68
gi|189083774 gelsolin isoform b [Homo sapiens] 258 3e-68
gi|189083772 gelsolin isoform b [Homo sapiens] 258 3e-68
gi|94721268 villin-like protein [Homo sapiens] 181 3e-45
gi|14916473 scinderin isoform 2 [Homo sapiens] 170 9e-42
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 155 2e-37
gi|63252913 gelsolin-like capping protein [Homo sapiens] 148 3e-35
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 147 8e-35
gi|238908508 leucine-rich repeat and death domain-containing pro... 144 7e-34
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 142 3e-33
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 132 3e-30
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 131 5e-30
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 131 5e-30
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 129 2e-29
gi|45827729 scribble isoform b [Homo sapiens] 126 2e-28
gi|45827731 scribble isoform a [Homo sapiens] 126 2e-28
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 115 3e-25
gi|197333692 leucine rich repeat containing 8 family, member B [... 112 2e-24
gi|21245134 leucine rich repeat containing 8 family, member B [H... 112 2e-24
gi|61742786 leucine rich repeat and death domain containing prot... 108 3e-23
gi|61742784 leucine rich repeat and death domain containing prot... 108 3e-23
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 2568 bits (6657), Expect = 0.0
Identities = 1269/1269 (100%), Positives = 1269/1269 (100%)
Query: 1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH 60
MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH
Sbjct: 1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEH 60
Query: 61 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP 120
LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP
Sbjct: 61 LSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECP 120
Query: 121 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV 180
RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV
Sbjct: 121 RELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLV 180
Query: 181 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 240
LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE
Sbjct: 181 LNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 240
Query: 241 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 300
CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN
Sbjct: 241 CLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLN 300
Query: 301 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH 360
SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH
Sbjct: 301 SNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIH 360
Query: 361 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP 420
FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP
Sbjct: 361 FLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASPATVAAAAAAGSGP 420
Query: 421 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL 480
KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL
Sbjct: 421 KDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQEKNKKQEESADARAPSGKVRRWDQGL 480
Query: 481 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS 540
EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS
Sbjct: 481 EKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS 540
Query: 541 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY 600
LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY
Sbjct: 541 LNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISY 600
Query: 601 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR 660
IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR
Sbjct: 601 IEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR 660
Query: 661 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED 720
GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED
Sbjct: 661 GAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPED 720
Query: 721 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC 780
FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC
Sbjct: 721 FWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC 780
Query: 781 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 840
WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD
Sbjct: 781 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 840
Query: 841 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW 900
VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW
Sbjct: 841 VLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEW 900
Query: 901 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE 960
NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE
Sbjct: 901 NEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAE 960
Query: 961 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR 1020
GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR
Sbjct: 961 GKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVR 1020
Query: 1021 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL 1080
MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL
Sbjct: 1021 MTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLL 1080
Query: 1081 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP 1140
NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP
Sbjct: 1081 NSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEP 1140
Query: 1141 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN 1200
ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN
Sbjct: 1141 ENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN 1200
Query: 1201 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA 1260
GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA
Sbjct: 1201 GQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHA 1260
Query: 1261 WSAFCKALA 1269
WSAFCKALA
Sbjct: 1261 WSAFCKALA 1269
>gi|162951877 scinderin isoform 1 [Homo sapiens]
Length = 715
Score = 280 bits (715), Expect = 8e-75
Identities = 229/797 (28%), Positives = 368/797 (46%), Gaps = 110/797 (13%)
Query: 487 YSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIY 546
Y E F G+ GL +W+IE V V ++ HG FY D Y+VL T G + ++
Sbjct: 6 YHEEFAR-AGKQAGLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRG-FTYHLH 63
Query: 547 YWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTA 606
+W+G E + D+ +AI V + +YLG + RE G ES +F+ F + Y GG A
Sbjct: 64 FWLGKECSQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVA 123
Query: 607 SGF-YTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQAT 665
SG + + + R+ V G++ ++ VPL S + F++D G +IY W G+
Sbjct: 124 SGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCN 183
Query: 666 LSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPEDFWP-- 723
KA A I NERKG++E+ ++ +G E E + LG +P +D
Sbjct: 184 KYERLKANQVATGIRYNERKGRSELIVVEEGSEPSELIKVLGEKPELPDGGDDDDIIADI 243
Query: 724 ---PQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD- 779
KLY V G + +++V ++ P M LL C +ILD
Sbjct: 244 SNRKMAKLYMVSDASG-------SMRVTVVAEENPFSMAM--------LLSEEC-FILDH 287
Query: 780 -CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNW 838
+F+W G+ + R AA+K +E ++ ++ + EG E +FK FK+W
Sbjct: 288 GAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDW 347
Query: 839 DDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLME 898
D QS G GKV EK Q+K +P L + Q+
Sbjct: 348 RD------------KDQSDGF-GKV-YVTEKVAQIKQ------IPFD-ASKLHSSPQMAA 386
Query: 899 EWNEDLDG---MEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDK 955
+ N DG +E + +E ++ + +G FY DCY+ L Y
Sbjct: 387 QHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTY--------------- 431
Query: 956 EEKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGK 1015
G+ I+Y WQG A+ T F L + + G+
Sbjct: 432 ------PRGQ-----------------IIYTWQGANATRDELTTSAF-LTVQLDRSLGGQ 467
Query: 1016 LEVVRMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPS----LYQIRTNGSALCTRCI 1071
+R++Q +E LS FK K +I + +G Q P+ L+Q+R N +++ TR +
Sbjct: 468 AVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASI-TRIV 526
Query: 1072 QINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSK 1131
+++ D++ LNS F+LK+P N G Y WVG+ + +E K AE + + +
Sbjct: 527 EVDVDANSLNSNDVFVLKLP----QNSG--YIWVGKGASQEEEKGAEYVASVL---KCKT 577
Query: 1132 QVINEGEEPENFFWVGIGAQKPYDD----DAEYMKH-TRLFRCSNEKGYFAVTEKCSDFC 1186
I EGEEPE FW +G +K Y + + H RL+ CSN+ G F + E +F
Sbjct: 578 LRIQEGEEPEE-FWNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTGRFVIEEIPGEFT 636
Query: 1187 QDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVR 1246
QDDLA+DD+MLLD +++++W+G ++VE K SLK+ ++Y++ S +R + +++
Sbjct: 637 QDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKR-TPIVIIK 695
Query: 1247 KGNEQHAFTRCFHAWSA 1263
+G+E FT F W +
Sbjct: 696 QGHEPPTFTGWFLGWDS 712
>gi|17572824 advillin [Homo sapiens]
Length = 819
Score = 280 bits (715), Expect = 8e-75
Identities = 232/783 (29%), Positives = 360/783 (45%), Gaps = 105/783 (13%)
Query: 499 PGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKK 558
PG+ +W+IE LV + HG FYE DCY++L T S L+ +I++WIG +++ D++
Sbjct: 14 PGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVAS-LLSQDIHFWIGKDSSQDEQ 72
Query: 559 ACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVE-DTHY 617
+C+AI+ L +YLG RE ES+ F F I Y +GG ASG VE +T+
Sbjct: 73 SCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVASGMKHVETNTYD 132
Query: 618 VTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAE 677
V R+ V GK+NI+ V + S + VFLLD G I W G ++ KA L A+
Sbjct: 133 VKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAMLLAK 192
Query: 678 KINKNERKGKAEITLLVQGQEL--PEFWEALG---GEPSEIKKHVPEDFWPPQPK----L 728
I ER G+AEI ++ +E PE + L G S IK VP++ + K L
Sbjct: 193 DIRDRERGGRAEIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDEIIDQKQKSTIML 252
Query: 729 YKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD-CWSDVFIW 787
Y + G L + ++ RP L+Q LL+ YILD + +++W
Sbjct: 253 YHISDSAGQLAVTEV--------ATRP---------LVQDLLNHDDCYILDQSGTKIYVW 295
Query: 788 LGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYT 847
G+ + + + AA+ M P V +G E+ +FK F+ W D T
Sbjct: 296 KGKGATKAEKQAAMSKALGFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWS---VKDQT 352
Query: 848 RNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGM 907
S G KV +D K D+T L + +A E+++++ N +
Sbjct: 353 MGLGKTF-SIGKIAKVFQD-------KFDVTLLHTKPE----VAAQERMVDDGN---GKV 397
Query: 908 EGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEA 967
E + +E + + + +G FY DCY+ L Y + GK
Sbjct: 398 EVWRIENLELVPVEYQWYGFFYGGDCYLVLYTY-----------------EVNGKPHH-- 438
Query: 968 TAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQEN 1027
I+Y WQGR AS L + + + F G VR+ E
Sbjct: 439 ---------------ILYIWQGRHAS-QDELAASAYQAVEVDRQFDGAAVQVRVRMGTEP 482
Query: 1028 PKFLSHFKRKFIIHRG--KRKAVQGAQQP-SLYQIRTNGSALCTRCIQINTDSSLLNSEF 1084
F++ FK K +I G RK P L+QI N + T+ +++ +S LNS
Sbjct: 483 RHFMAIFKGKLVIFEGGTSRKGNAEPDPPVRLFQIHGNDKS-NTKAVEVPAFASSLNSND 541
Query: 1085 CFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFF 1144
F+L+ E Y W G+ S DE +A+++ + + D S+ + EG+EP F
Sbjct: 542 VFLLRTQAEH-------YLWYGKGSSGDERAMAKELASLLCDG--SENTVAEGQEPAE-F 591
Query: 1145 WVGIGAQKPYDDDAEYMK-----HTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLD 1199
W +G + PY +D + +RLF CSN+ G F VTE +DF QDDL D+MLLD
Sbjct: 592 WDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFVVTE-ITDFTQDDLNPTDVMLLD 650
Query: 1200 NGQEVYMWVGTQTSQVEIKLSLKACQVYIQ-HMRSKEHERPRRLRLVRKGNEQHAFTRCF 1258
+V++W+G + + E + +L Q Y+ H ++ + P + ++++G E FT F
Sbjct: 651 TWDQVFLWIGAEANATEKESALATAQQYLHTHPSGRDPDTP--ILIIKQGFEPPIFTGWF 708
Query: 1259 HAW 1261
AW
Sbjct: 709 LAW 711
Score = 120 bits (302), Expect = 6e-27
Identities = 96/345 (27%), Positives = 148/345 (42%), Gaps = 39/345 (11%)
Query: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
+W+IEN V VE ++G FY DCY+VL T+ + +G + +Y W G A+ D+ A SA
Sbjct: 399 VWRIENLELVPVEYQWYGFFYGGDCYLVLYTY-EVNGKPHHILYIWQGRHASQDELAASA 457
Query: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMY 622
AV + VR MG E F+ +F + EGGT+ D R++
Sbjct: 458 YQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKLVIFEGGTSRKGNAEPDP--PVRLF 515
Query: 623 RVYG--KKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKIN 680
+++G K N K VP +SL+ VFLL + Y+W G ++ A+ A +
Sbjct: 516 QIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAEHYLWYGKGSSGDERAMAKELASLLC 575
Query: 681 KNERKGKAEITLLVQGQELPEFWEALGGE-PSEIKKHVPEDFWPPQPKLYKVGLGLGYLE 739
AE GQE EFW+ LGG+ P K + ++ Q +L++ G
Sbjct: 576 DGSENTVAE------GQEPAEFWDLLGGKTPYANDKRLQQEILDVQSRLFECSNKTGQFV 629
Query: 740 LPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAA 799
+ +I Q L+ V +LD W VF+W+G ++ + +
Sbjct: 630 VTEIT-------------------DFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKES 670
Query: 800 ALKLGQELCGMLH-----RPRHATVSRSLEGTEAQVFKAKFKNWD 839
AL Q+ LH R + +G E +F F WD
Sbjct: 671 ALATAQQ---YLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWD 712
Score = 42.4 bits (98), Expect = 0.003
Identities = 28/99 (28%), Positives = 46/99 (46%), Gaps = 5/99 (5%)
Query: 1166 LFRCSNEKGYFAVTEKCS-DFCQDDLADDDIMLLD-NGQEVYMWVGTQTSQVEIKLSLKA 1223
L+ S+ G AVTE + QD L DD +LD +G ++Y+W G ++ E + ++
Sbjct: 252 LYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSK 311
Query: 1224 CQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWS 1262
+I + K + + V G E F + F WS
Sbjct: 312 ALGFI---KMKSYPSSTNVETVNDGAESAMFKQLFQKWS 347
>gi|194394237 villin 1 [Homo sapiens]
Length = 827
Score = 270 bits (690), Expect = 6e-72
Identities = 218/786 (27%), Positives = 358/786 (45%), Gaps = 105/786 (13%)
Query: 499 PGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKK 558
PGL IW+IE V V + G F++ DCYI+L S SL+++I+YWIG +++LD++
Sbjct: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTAS-SLSYDIHYWIGQDSSLDEQ 75
Query: 559 ACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHY- 617
+AI+ + ++L RE G+ESE F F + +GG ASG VE Y
Sbjct: 76 GAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYD 135
Query: 618 VTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAE 677
V R+ V GK+N+ V + S + VFLLD G I W G ++T + A+
Sbjct: 136 VQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
Query: 678 KINKNERKGKAEITLLVQGQEL--PEFWEALG---GEPSEIKKHVPEDFWPP----QPKL 728
+I ER G+ + ++ EL P+ E + G+ E+K VP+ P KL
Sbjct: 196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAALKL 255
Query: 729 YKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWS-DVFIW 787
Y V G L + ++ RP L Q LL YILD +++W
Sbjct: 256 YHVSDSEGNLVVREV--------ATRP---------LTQDLLSHEDCYILDQGGLKIYVW 298
Query: 788 LGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYT 847
G+K+ + A+ P V +G E+ VF+ F+ W
Sbjct: 299 KGKKANEQEKKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWT-------A 351
Query: 848 RNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGM 907
N + L G V K +Q+K D T++ + Q +A ++++++ + + +
Sbjct: 352 SNRTSGLGKTHTVGSV----AKVEQVKFDATSMHVKPQ----VAAQQKMVDDGSGE---V 400
Query: 908 EGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEA 967
+ + +E + + + GHFY DCY+ L Y +
Sbjct: 401 QVWRIENLELVPVDSKWLGHFYGGDCYLLLYTYLI------------------------- 435
Query: 968 TAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQEN 1027
EKQ ++Y WQG +AS +T + + + G+ +R+ +E
Sbjct: 436 ----GEKQ-----HYLLYVWQGSQAS-QDEITASAYQAVILDQKYNGEPVQIRVPMGKEP 485
Query: 1028 PKFLSHFKRKFIIHRG---KRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEF 1084
P +S FK + ++++G + ++ L+Q++ G A T+ ++ ++ LNS
Sbjct: 486 PHLMSIFKGRMVVYQGGTSRTNNLETGPSTRLFQVQGTG-ANNTKAFEVPARANFLNSND 544
Query: 1085 CFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFF 1144
F+LK Q Y W G+ DE ++A+ + +T+ T KQV+ EG+EP N F
Sbjct: 545 VFVLK-------TQSCCYLWCGKGCSGDEREMAKMVADTISRT--EKQVVVEGQEPAN-F 594
Query: 1145 WVGIGAQKPYDDDAEYMKHT-----RLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLD 1199
W+ +G + PY + + RLF CSN+ G F TE DF QDDL +DD+ LLD
Sbjct: 595 WMALGGKAPYANTKRLQEENLVITPRLFECSNKTGRFLATE-IPDFNQDDLEEDDVFLLD 653
Query: 1200 NGQEVYMWVGTQTSQVEIKLSLKACQVYIQ-HMRSKEHERPRRLRLVRKGNEQHAFTRCF 1258
+V+ W+G ++ E K + Q Y++ H ++ E P + +V++G+E FT F
Sbjct: 654 VWDQVFFWIGKHANEEEKKAAATTAQEYLKTHPSGRDPETP--IIVVKQGHEPPTFTGWF 711
Query: 1259 HAWSAF 1264
AW F
Sbjct: 712 LAWDPF 717
>gi|4504165 gelsolin isoform a precursor [Homo sapiens]
Length = 782
Score = 259 bits (661), Expect = 1e-68
Identities = 227/820 (27%), Positives = 362/820 (44%), Gaps = 111/820 (13%)
Query: 463 SADARAPSGKVRRWDQGLEKPR---LDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFH 519
++ A AP G+V +P +++ EF G+ PGL IW++E F V V +
Sbjct: 34 ASQAGAPQGRVPE-----ARPNSMVVEHPEFLK--AGKEPGLQIWRVEKFDLVPVPTNLY 86
Query: 520 GKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTV 579
G F+ D Y++LKT +G+L ++++YW+G E + D+ +AI V L +YL
Sbjct: 87 GDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQH 146
Query: 580 REEMGDESEEFLQVFDNDISYIEGGTASGF-YTVEDTHYVTRMYRVYGKKNIKLEPVPLK 638
RE G ES FL F + + Y +GG ASGF + V + V R+++V G++ ++ VP+
Sbjct: 147 REVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVS 206
Query: 639 GTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQE 698
S + F+LD G +I+ W G+ + KA ++ I NER G+A + + +G E
Sbjct: 207 WESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTE 266
Query: 699 LPEFWEALGGE---PSEIKKHVPEDFWPPQ-PKLYKVGLGLGYLELPQINYKLSVEHKQR 754
+ LG + P+ + ED + KLYKV G G + +S+ +
Sbjct: 267 PEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKLYKVSNGAGTM-------SVSLVADEN 319
Query: 755 PKVELMPRMRLLQSLLDTRCVYILDCWSD--VFIWLGRKSPRLVRAAALKLGQELCGMLH 812
P Q L + +ILD D +F+W G+++ R AALK + +
Sbjct: 320 P---------FAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKTASDFITKMD 370
Query: 813 RPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQ 872
P+ VS EG E +FK FKNW D D GLS + ++
Sbjct: 371 YPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTD----------GLGLS-YLSSHIANVER 419
Query: 873 MKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGMEG-FVLEGKKFARLPEEEFGHFYTQ 931
+ D L S A A Q ++D G + + +EG + +G FY
Sbjct: 420 VPFDAATLH------TSTAMAAQ--HGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGG 471
Query: 932 DCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGRE 991
D Y+ L Y + G++G+ I+Y WQG +
Sbjct: 472 DSYIILYNY-----------------RHGGRQGQ-----------------IIYNWQGAQ 497
Query: 992 ASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRK-FIIHRGKRKAVQG 1050
S + + L + + G R+ Q +E +S F K II++G G
Sbjct: 498 -STQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGG 556
Query: 1051 AQQPS---LYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGR 1107
P+ L+Q+R N SA TR +++ + LNS F+LK P Y WVG
Sbjct: 557 QTAPASTRLFQVRAN-SAGATRAVEVLPKAGALNSNDAFVLKTP-------SAAYLWVGT 608
Query: 1108 ASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYD-----DDAEYMK 1162
+ E A+++L + + EG EP+ FW +G + Y D +
Sbjct: 609 GASEAEKTGAQELLRVL---RAQPVQVAEGSEPDG-FWEALGGKAAYRTSPRLKDKKMDA 664
Query: 1163 H-TRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSL 1221
H RLF CSN+ G F + E + Q+DLA DD+MLLD +V++WVG + + E +L
Sbjct: 665 HPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEAL 724
Query: 1222 KACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAW 1261
+ + YI+ +R + +V++G E +F F W
Sbjct: 725 TSAKRYIE-TDPANRDRRTPITVVKQGFEPPSFVGWFLGW 763
Score = 92.8 bits (229), Expect = 2e-18
Identities = 95/348 (27%), Positives = 141/348 (40%), Gaps = 41/348 (11%)
Query: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
IW+IE V V+ A +G+FY D YI+L + G IY W G ++T D+ A SA
Sbjct: 449 IWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRH-GGRQGQIIYNWQGAQSTQDEVAASA 507
Query: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDND--ISYIEGGTASGFYTVEDTHYVTR 620
I L LG R G E + +F I Y G + G T + TR
Sbjct: 508 ILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS---TR 564
Query: 621 MYRVYGKKNIKLEPVPL--KGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEK 678
+++V V + K +L+ F+L Y+W G A+ + T A+
Sbjct: 565 LFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRV 624
Query: 679 INKNERKGKAEITLLVQGQELPEFWEALGGEP----SEIKKHVPEDFWPPQPKLYKVGLG 734
+ +A+ + +G E FWEALGG+ S K D PP +L+
Sbjct: 625 L-------RAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPP--RLFACSNK 675
Query: 735 LGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPR 794
+G R +E +P L+Q L T V +LD W VF+W+G+ S
Sbjct: 676 IG-----------------RFVIEEVPG-ELMQEDLATDDVMLLDTWDQVFVWVGKDSQE 717
Query: 795 LVRAAALKLGQEL--CGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 840
+ AL + +R R ++ +G E F F WDD
Sbjct: 718 EEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDD 765
>gi|38044288 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 258 bits (658), Expect = 3e-68
Identities = 221/795 (27%), Positives = 352/795 (44%), Gaps = 103/795 (12%)
Query: 485 LDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWE 544
+++ EF G+ PGL IW++E F V V +G F+ D Y++LKT +G+L ++
Sbjct: 3 VEHPEFLK--AGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYD 60
Query: 545 IYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGG 604
++YW+G E + D+ +AI V L +YL RE G ES FL F + + Y +GG
Sbjct: 61 LHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGG 120
Query: 605 TASGF-YTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQ 663
ASGF + V + V R+++V G++ ++ VP+ S + F+LD G +I+ W G+
Sbjct: 121 VASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSN 180
Query: 664 ATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGE---PSEIKKHVPED 720
+ KA ++ I NER G+A + + +G E + LG + P+ + ED
Sbjct: 181 SNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKED 240
Query: 721 FWPPQ-PKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD 779
+ KLYKV G G + +S+ + P Q L + +ILD
Sbjct: 241 AANRKLAKLYKVSNGAGTM-------SVSLVADENP---------FAQGALKSEDCFILD 284
Query: 780 CWSD--VFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKN 837
D +F+W G+++ R AALK + + P+ VS EG E +FK FKN
Sbjct: 285 HGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKN 344
Query: 838 WDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLM 897
W D D GLS + +++ D L S A A Q
Sbjct: 345 WRDPDQTD----------GLGLS-YLSSHIANVERVPFDAATLH------TSTAMAAQ-- 385
Query: 898 EEWNEDLDGMEG-FVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKE 956
++D G + + +EG + +G FY D Y+ L Y
Sbjct: 386 HGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNY---------------- 429
Query: 957 EKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKL 1016
+ G++G+ I+Y WQG + S + + L + + G
Sbjct: 430 -RHGGRQGQ-----------------IIYNWQGAQ-STQDEVAASAILTAQLDEELGGTP 470
Query: 1017 EVVRMTQQQENPKFLSHFKRK-FIIHRGKRKAVQGAQQPS---LYQIRTNGSALCTRCIQ 1072
R+ Q +E +S F K II++G G P+ L+Q+R N SA TR ++
Sbjct: 471 VQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRAN-SAGATRAVE 529
Query: 1073 INTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQ 1132
+ + LNS F+LK P Y WVG + E A+++L +
Sbjct: 530 VLPKAGALNSNDAFVLKTP-------SAAYLWVGTGASEAEKTGAQELLRVL---RAQPV 579
Query: 1133 VINEGEEPENFFWVGIGAQKPYD-----DDAEYMKH-TRLFRCSNEKGYFAVTEKCSDFC 1186
+ EG EP+ FW +G + Y D + H RLF CSN+ G F + E +
Sbjct: 580 QVAEGSEPDG-FWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELM 638
Query: 1187 QDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVR 1246
Q+DLA DD+MLLD +V++WVG + + E +L + + YI+ +R + +V+
Sbjct: 639 QEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIE-TDPANRDRRTPITVVK 697
Query: 1247 KGNEQHAFTRCFHAW 1261
+G E +F F W
Sbjct: 698 QGFEPPSFVGWFLGW 712
Score = 92.8 bits (229), Expect = 2e-18
Identities = 95/348 (27%), Positives = 141/348 (40%), Gaps = 41/348 (11%)
Query: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
IW+IE V V+ A +G+FY D YI+L + G IY W G ++T D+ A SA
Sbjct: 398 IWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRH-GGRQGQIIYNWQGAQSTQDEVAASA 456
Query: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDND--ISYIEGGTASGFYTVEDTHYVTR 620
I L LG R G E + +F I Y G + G T + TR
Sbjct: 457 ILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS---TR 513
Query: 621 MYRVYGKKNIKLEPVPL--KGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEK 678
+++V V + K +L+ F+L Y+W G A+ + T A+
Sbjct: 514 LFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRV 573
Query: 679 INKNERKGKAEITLLVQGQELPEFWEALGGEP----SEIKKHVPEDFWPPQPKLYKVGLG 734
+ +A+ + +G E FWEALGG+ S K D PP +L+
Sbjct: 574 L-------RAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPP--RLFACSNK 624
Query: 735 LGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPR 794
+G R +E +P L+Q L T V +LD W VF+W+G+ S
Sbjct: 625 IG-----------------RFVIEEVPG-ELMQEDLATDDVMLLDTWDQVFVWVGKDSQE 666
Query: 795 LVRAAALKLGQEL--CGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 840
+ AL + +R R ++ +G E F F WDD
Sbjct: 667 EEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDD 714
>gi|189083782 gelsolin isoform c [Homo sapiens]
Length = 742
Score = 258 bits (658), Expect = 3e-68
Identities = 221/795 (27%), Positives = 352/795 (44%), Gaps = 103/795 (12%)
Query: 485 LDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWE 544
+++ EF G+ PGL IW++E F V V +G F+ D Y++LKT +G+L ++
Sbjct: 14 VEHPEFLK--AGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYD 71
Query: 545 IYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGG 604
++YW+G E + D+ +AI V L +YL RE G ES FL F + + Y +GG
Sbjct: 72 LHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGG 131
Query: 605 TASGF-YTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQ 663
ASGF + V + V R+++V G++ ++ VP+ S + F+LD G +I+ W G+
Sbjct: 132 VASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSN 191
Query: 664 ATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGE---PSEIKKHVPED 720
+ KA ++ I NER G+A + + +G E + LG + P+ + ED
Sbjct: 192 SNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKED 251
Query: 721 FWPPQ-PKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD 779
+ KLYKV G G + +S+ + P Q L + +ILD
Sbjct: 252 AANRKLAKLYKVSNGAGTM-------SVSLVADENP---------FAQGALKSEDCFILD 295
Query: 780 CWSD--VFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKN 837
D +F+W G+++ R AALK + + P+ VS EG E +FK FKN
Sbjct: 296 HGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKN 355
Query: 838 WDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLM 897
W D D GLS + +++ D L S A A Q
Sbjct: 356 WRDPDQTD----------GLGLS-YLSSHIANVERVPFDAATLH------TSTAMAAQ-- 396
Query: 898 EEWNEDLDGMEG-FVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKE 956
++D G + + +EG + +G FY D Y+ L Y
Sbjct: 397 HGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNY---------------- 440
Query: 957 EKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKL 1016
+ G++G+ I+Y WQG + S + + L + + G
Sbjct: 441 -RHGGRQGQ-----------------IIYNWQGAQ-STQDEVAASAILTAQLDEELGGTP 481
Query: 1017 EVVRMTQQQENPKFLSHFKRK-FIIHRGKRKAVQGAQQPS---LYQIRTNGSALCTRCIQ 1072
R+ Q +E +S F K II++G G P+ L+Q+R N SA TR ++
Sbjct: 482 VQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRAN-SAGATRAVE 540
Query: 1073 INTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQ 1132
+ + LNS F+LK P Y WVG + E A+++L +
Sbjct: 541 VLPKAGALNSNDAFVLKTP-------SAAYLWVGTGASEAEKTGAQELLRVL---RAQPV 590
Query: 1133 VINEGEEPENFFWVGIGAQKPYD-----DDAEYMKH-TRLFRCSNEKGYFAVTEKCSDFC 1186
+ EG EP+ FW +G + Y D + H RLF CSN+ G F + E +
Sbjct: 591 QVAEGSEPDG-FWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELM 649
Query: 1187 QDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVR 1246
Q+DLA DD+MLLD +V++WVG + + E +L + + YI+ +R + +V+
Sbjct: 650 QEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIE-TDPANRDRRTPITVVK 708
Query: 1247 KGNEQHAFTRCFHAW 1261
+G E +F F W
Sbjct: 709 QGFEPPSFVGWFLGW 723
Score = 92.8 bits (229), Expect = 2e-18
Identities = 95/348 (27%), Positives = 141/348 (40%), Gaps = 41/348 (11%)
Query: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
IW+IE V V+ A +G+FY D YI+L + G IY W G ++T D+ A SA
Sbjct: 409 IWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRH-GGRQGQIIYNWQGAQSTQDEVAASA 467
Query: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDND--ISYIEGGTASGFYTVEDTHYVTR 620
I L LG R G E + +F I Y G + G T + TR
Sbjct: 468 ILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS---TR 524
Query: 621 MYRVYGKKNIKLEPVPL--KGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEK 678
+++V V + K +L+ F+L Y+W G A+ + T A+
Sbjct: 525 LFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRV 584
Query: 679 INKNERKGKAEITLLVQGQELPEFWEALGGEP----SEIKKHVPEDFWPPQPKLYKVGLG 734
+ +A+ + +G E FWEALGG+ S K D PP +L+
Sbjct: 585 L-------RAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPP--RLFACSNK 635
Query: 735 LGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPR 794
+G R +E +P L+Q L T V +LD W VF+W+G+ S
Sbjct: 636 IG-----------------RFVIEEVPG-ELMQEDLATDDVMLLDTWDQVFVWVGKDSQE 677
Query: 795 LVRAAALKLGQEL--CGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 840
+ AL + +R R ++ +G E F F WDD
Sbjct: 678 EEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDD 725
>gi|189083780 gelsolin isoform c [Homo sapiens]
Length = 742
Score = 258 bits (658), Expect = 3e-68
Identities = 221/795 (27%), Positives = 352/795 (44%), Gaps = 103/795 (12%)
Query: 485 LDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWE 544
+++ EF G+ PGL IW++E F V V +G F+ D Y++LKT +G+L ++
Sbjct: 14 VEHPEFLK--AGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYD 71
Query: 545 IYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGG 604
++YW+G E + D+ +AI V L +YL RE G ES FL F + + Y +GG
Sbjct: 72 LHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGG 131
Query: 605 TASGF-YTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQ 663
ASGF + V + V R+++V G++ ++ VP+ S + F+LD G +I+ W G+
Sbjct: 132 VASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSN 191
Query: 664 ATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGE---PSEIKKHVPED 720
+ KA ++ I NER G+A + + +G E + LG + P+ + ED
Sbjct: 192 SNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKED 251
Query: 721 FWPPQ-PKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD 779
+ KLYKV G G + +S+ + P Q L + +ILD
Sbjct: 252 AANRKLAKLYKVSNGAGTM-------SVSLVADENP---------FAQGALKSEDCFILD 295
Query: 780 CWSD--VFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKN 837
D +F+W G+++ R AALK + + P+ VS EG E +FK FKN
Sbjct: 296 HGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKN 355
Query: 838 WDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLM 897
W D D GLS + +++ D L S A A Q
Sbjct: 356 WRDPDQTD----------GLGLS-YLSSHIANVERVPFDAATLH------TSTAMAAQ-- 396
Query: 898 EEWNEDLDGMEG-FVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKE 956
++D G + + +EG + +G FY D Y+ L Y
Sbjct: 397 HGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNY---------------- 440
Query: 957 EKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKL 1016
+ G++G+ I+Y WQG + S + + L + + G
Sbjct: 441 -RHGGRQGQ-----------------IIYNWQGAQ-STQDEVAASAILTAQLDEELGGTP 481
Query: 1017 EVVRMTQQQENPKFLSHFKRK-FIIHRGKRKAVQGAQQPS---LYQIRTNGSALCTRCIQ 1072
R+ Q +E +S F K II++G G P+ L+Q+R N SA TR ++
Sbjct: 482 VQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRAN-SAGATRAVE 540
Query: 1073 INTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQ 1132
+ + LNS F+LK P Y WVG + E A+++L +
Sbjct: 541 VLPKAGALNSNDAFVLKTP-------SAAYLWVGTGASEAEKTGAQELLRVL---RAQPV 590
Query: 1133 VINEGEEPENFFWVGIGAQKPYD-----DDAEYMKH-TRLFRCSNEKGYFAVTEKCSDFC 1186
+ EG EP+ FW +G + Y D + H RLF CSN+ G F + E +
Sbjct: 591 QVAEGSEPDG-FWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELM 649
Query: 1187 QDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVR 1246
Q+DLA DD+MLLD +V++WVG + + E +L + + YI+ +R + +V+
Sbjct: 650 QEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIE-TDPANRDRRTPITVVK 708
Query: 1247 KGNEQHAFTRCFHAW 1261
+G E +F F W
Sbjct: 709 QGFEPPSFVGWFLGW 723
Score = 92.8 bits (229), Expect = 2e-18
Identities = 95/348 (27%), Positives = 141/348 (40%), Gaps = 41/348 (11%)
Query: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
IW+IE V V+ A +G+FY D YI+L + G IY W G ++T D+ A SA
Sbjct: 409 IWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRH-GGRQGQIIYNWQGAQSTQDEVAASA 467
Query: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDND--ISYIEGGTASGFYTVEDTHYVTR 620
I L LG R G E + +F I Y G + G T + TR
Sbjct: 468 ILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS---TR 524
Query: 621 MYRVYGKKNIKLEPVPL--KGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEK 678
+++V V + K +L+ F+L Y+W G A+ + T A+
Sbjct: 525 LFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRV 584
Query: 679 INKNERKGKAEITLLVQGQELPEFWEALGGEP----SEIKKHVPEDFWPPQPKLYKVGLG 734
+ +A+ + +G E FWEALGG+ S K D PP +L+
Sbjct: 585 L-------RAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPP--RLFACSNK 635
Query: 735 LGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPR 794
+G R +E +P L+Q L T V +LD W VF+W+G+ S
Sbjct: 636 IG-----------------RFVIEEVPG-ELMQEDLATDDVMLLDTWDQVFVWVGKDSQE 677
Query: 795 LVRAAALKLGQEL--CGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 840
+ AL + +R R ++ +G E F F WDD
Sbjct: 678 EEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDD 725
>gi|189083778 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 258 bits (658), Expect = 3e-68
Identities = 221/795 (27%), Positives = 352/795 (44%), Gaps = 103/795 (12%)
Query: 485 LDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWE 544
+++ EF G+ PGL IW++E F V V +G F+ D Y++LKT +G+L ++
Sbjct: 3 VEHPEFLK--AGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYD 60
Query: 545 IYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGG 604
++YW+G E + D+ +AI V L +YL RE G ES FL F + + Y +GG
Sbjct: 61 LHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGG 120
Query: 605 TASGF-YTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQ 663
ASGF + V + V R+++V G++ ++ VP+ S + F+LD G +I+ W G+
Sbjct: 121 VASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSN 180
Query: 664 ATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGE---PSEIKKHVPED 720
+ KA ++ I NER G+A + + +G E + LG + P+ + ED
Sbjct: 181 SNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKED 240
Query: 721 FWPPQ-PKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD 779
+ KLYKV G G + +S+ + P Q L + +ILD
Sbjct: 241 AANRKLAKLYKVSNGAGTM-------SVSLVADENP---------FAQGALKSEDCFILD 284
Query: 780 CWSD--VFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKN 837
D +F+W G+++ R AALK + + P+ VS EG E +FK FKN
Sbjct: 285 HGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKN 344
Query: 838 WDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLM 897
W D D GLS + +++ D L S A A Q
Sbjct: 345 WRDPDQTD----------GLGLS-YLSSHIANVERVPFDAATLH------TSTAMAAQ-- 385
Query: 898 EEWNEDLDGMEG-FVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKE 956
++D G + + +EG + +G FY D Y+ L Y
Sbjct: 386 HGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNY---------------- 429
Query: 957 EKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKL 1016
+ G++G+ I+Y WQG + S + + L + + G
Sbjct: 430 -RHGGRQGQ-----------------IIYNWQGAQ-STQDEVAASAILTAQLDEELGGTP 470
Query: 1017 EVVRMTQQQENPKFLSHFKRK-FIIHRGKRKAVQGAQQPS---LYQIRTNGSALCTRCIQ 1072
R+ Q +E +S F K II++G G P+ L+Q+R N SA TR ++
Sbjct: 471 VQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRAN-SAGATRAVE 529
Query: 1073 INTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQ 1132
+ + LNS F+LK P Y WVG + E A+++L +
Sbjct: 530 VLPKAGALNSNDAFVLKTP-------SAAYLWVGTGASEAEKTGAQELLRVL---RAQPV 579
Query: 1133 VINEGEEPENFFWVGIGAQKPYD-----DDAEYMKH-TRLFRCSNEKGYFAVTEKCSDFC 1186
+ EG EP+ FW +G + Y D + H RLF CSN+ G F + E +
Sbjct: 580 QVAEGSEPDG-FWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELM 638
Query: 1187 QDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVR 1246
Q+DLA DD+MLLD +V++WVG + + E +L + + YI+ +R + +V+
Sbjct: 639 QEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIE-TDPANRDRRTPITVVK 697
Query: 1247 KGNEQHAFTRCFHAW 1261
+G E +F F W
Sbjct: 698 QGFEPPSFVGWFLGW 712
Score = 92.8 bits (229), Expect = 2e-18
Identities = 95/348 (27%), Positives = 141/348 (40%), Gaps = 41/348 (11%)
Query: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
IW+IE V V+ A +G+FY D YI+L + G IY W G ++T D+ A SA
Sbjct: 398 IWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRH-GGRQGQIIYNWQGAQSTQDEVAASA 456
Query: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDND--ISYIEGGTASGFYTVEDTHYVTR 620
I L LG R G E + +F I Y G + G T + TR
Sbjct: 457 ILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS---TR 513
Query: 621 MYRVYGKKNIKLEPVPL--KGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEK 678
+++V V + K +L+ F+L Y+W G A+ + T A+
Sbjct: 514 LFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRV 573
Query: 679 INKNERKGKAEITLLVQGQELPEFWEALGGEP----SEIKKHVPEDFWPPQPKLYKVGLG 734
+ +A+ + +G E FWEALGG+ S K D PP +L+
Sbjct: 574 L-------RAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPP--RLFACSNK 624
Query: 735 LGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPR 794
+G R +E +P L+Q L T V +LD W VF+W+G+ S
Sbjct: 625 IG-----------------RFVIEEVPG-ELMQEDLATDDVMLLDTWDQVFVWVGKDSQE 666
Query: 795 LVRAAALKLGQEL--CGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 840
+ AL + +R R ++ +G E F F WDD
Sbjct: 667 EEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDD 714
>gi|189083776 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 258 bits (658), Expect = 3e-68
Identities = 221/795 (27%), Positives = 352/795 (44%), Gaps = 103/795 (12%)
Query: 485 LDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWE 544
+++ EF G+ PGL IW++E F V V +G F+ D Y++LKT +G+L ++
Sbjct: 3 VEHPEFLK--AGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYD 60
Query: 545 IYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGG 604
++YW+G E + D+ +AI V L +YL RE G ES FL F + + Y +GG
Sbjct: 61 LHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGG 120
Query: 605 TASGF-YTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQ 663
ASGF + V + V R+++V G++ ++ VP+ S + F+LD G +I+ W G+
Sbjct: 121 VASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSN 180
Query: 664 ATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGE---PSEIKKHVPED 720
+ KA ++ I NER G+A + + +G E + LG + P+ + ED
Sbjct: 181 SNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKED 240
Query: 721 FWPPQ-PKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD 779
+ KLYKV G G + +S+ + P Q L + +ILD
Sbjct: 241 AANRKLAKLYKVSNGAGTM-------SVSLVADENP---------FAQGALKSEDCFILD 284
Query: 780 CWSD--VFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKN 837
D +F+W G+++ R AALK + + P+ VS EG E +FK FKN
Sbjct: 285 HGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKN 344
Query: 838 WDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLM 897
W D D GLS + +++ D L S A A Q
Sbjct: 345 WRDPDQTD----------GLGLS-YLSSHIANVERVPFDAATLH------TSTAMAAQ-- 385
Query: 898 EEWNEDLDGMEG-FVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKE 956
++D G + + +EG + +G FY D Y+ L Y
Sbjct: 386 HGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNY---------------- 429
Query: 957 EKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKL 1016
+ G++G+ I+Y WQG + S + + L + + G
Sbjct: 430 -RHGGRQGQ-----------------IIYNWQGAQ-STQDEVAASAILTAQLDEELGGTP 470
Query: 1017 EVVRMTQQQENPKFLSHFKRK-FIIHRGKRKAVQGAQQPS---LYQIRTNGSALCTRCIQ 1072
R+ Q +E +S F K II++G G P+ L+Q+R N SA TR ++
Sbjct: 471 VQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRAN-SAGATRAVE 529
Query: 1073 INTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQ 1132
+ + LNS F+LK P Y WVG + E A+++L +
Sbjct: 530 VLPKAGALNSNDAFVLKTP-------SAAYLWVGTGASEAEKTGAQELLRVL---RAQPV 579
Query: 1133 VINEGEEPENFFWVGIGAQKPYD-----DDAEYMKH-TRLFRCSNEKGYFAVTEKCSDFC 1186
+ EG EP+ FW +G + Y D + H RLF CSN+ G F + E +
Sbjct: 580 QVAEGSEPDG-FWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELM 638
Query: 1187 QDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVR 1246
Q+DLA DD+MLLD +V++WVG + + E +L + + YI+ +R + +V+
Sbjct: 639 QEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIE-TDPANRDRRTPITVVK 697
Query: 1247 KGNEQHAFTRCFHAW 1261
+G E +F F W
Sbjct: 698 QGFEPPSFVGWFLGW 712
Score = 92.8 bits (229), Expect = 2e-18
Identities = 95/348 (27%), Positives = 141/348 (40%), Gaps = 41/348 (11%)
Query: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
IW+IE V V+ A +G+FY D YI+L + G IY W G ++T D+ A SA
Sbjct: 398 IWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRH-GGRQGQIIYNWQGAQSTQDEVAASA 456
Query: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDND--ISYIEGGTASGFYTVEDTHYVTR 620
I L LG R G E + +F I Y G + G T + TR
Sbjct: 457 ILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS---TR 513
Query: 621 MYRVYGKKNIKLEPVPL--KGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEK 678
+++V V + K +L+ F+L Y+W G A+ + T A+
Sbjct: 514 LFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRV 573
Query: 679 INKNERKGKAEITLLVQGQELPEFWEALGGEP----SEIKKHVPEDFWPPQPKLYKVGLG 734
+ +A+ + +G E FWEALGG+ S K D PP +L+
Sbjct: 574 L-------RAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPP--RLFACSNK 624
Query: 735 LGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPR 794
+G R +E +P L+Q L T V +LD W VF+W+G+ S
Sbjct: 625 IG-----------------RFVIEEVPG-ELMQEDLATDDVMLLDTWDQVFVWVGKDSQE 666
Query: 795 LVRAAALKLGQEL--CGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 840
+ AL + +R R ++ +G E F F WDD
Sbjct: 667 EEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDD 714
>gi|189083774 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 258 bits (658), Expect = 3e-68
Identities = 221/795 (27%), Positives = 352/795 (44%), Gaps = 103/795 (12%)
Query: 485 LDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWE 544
+++ EF G+ PGL IW++E F V V +G F+ D Y++LKT +G+L ++
Sbjct: 3 VEHPEFLK--AGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYD 60
Query: 545 IYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGG 604
++YW+G E + D+ +AI V L +YL RE G ES FL F + + Y +GG
Sbjct: 61 LHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGG 120
Query: 605 TASGF-YTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQ 663
ASGF + V + V R+++V G++ ++ VP+ S + F+LD G +I+ W G+
Sbjct: 121 VASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSN 180
Query: 664 ATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGE---PSEIKKHVPED 720
+ KA ++ I NER G+A + + +G E + LG + P+ + ED
Sbjct: 181 SNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKED 240
Query: 721 FWPPQ-PKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD 779
+ KLYKV G G + +S+ + P Q L + +ILD
Sbjct: 241 AANRKLAKLYKVSNGAGTM-------SVSLVADENP---------FAQGALKSEDCFILD 284
Query: 780 CWSD--VFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKN 837
D +F+W G+++ R AALK + + P+ VS EG E +FK FKN
Sbjct: 285 HGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKN 344
Query: 838 WDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLM 897
W D D GLS + +++ D L S A A Q
Sbjct: 345 WRDPDQTD----------GLGLS-YLSSHIANVERVPFDAATLH------TSTAMAAQ-- 385
Query: 898 EEWNEDLDGMEG-FVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKE 956
++D G + + +EG + +G FY D Y+ L Y
Sbjct: 386 HGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNY---------------- 429
Query: 957 EKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKL 1016
+ G++G+ I+Y WQG + S + + L + + G
Sbjct: 430 -RHGGRQGQ-----------------IIYNWQGAQ-STQDEVAASAILTAQLDEELGGTP 470
Query: 1017 EVVRMTQQQENPKFLSHFKRK-FIIHRGKRKAVQGAQQPS---LYQIRTNGSALCTRCIQ 1072
R+ Q +E +S F K II++G G P+ L+Q+R N SA TR ++
Sbjct: 471 VQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRAN-SAGATRAVE 529
Query: 1073 INTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQ 1132
+ + LNS F+LK P Y WVG + E A+++L +
Sbjct: 530 VLPKAGALNSNDAFVLKTP-------SAAYLWVGTGASEAEKTGAQELLRVL---RAQPV 579
Query: 1133 VINEGEEPENFFWVGIGAQKPYD-----DDAEYMKH-TRLFRCSNEKGYFAVTEKCSDFC 1186
+ EG EP+ FW +G + Y D + H RLF CSN+ G F + E +
Sbjct: 580 QVAEGSEPDG-FWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELM 638
Query: 1187 QDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVR 1246
Q+DLA DD+MLLD +V++WVG + + E +L + + YI+ +R + +V+
Sbjct: 639 QEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIE-TDPANRDRRTPITVVK 697
Query: 1247 KGNEQHAFTRCFHAW 1261
+G E +F F W
Sbjct: 698 QGFEPPSFVGWFLGW 712
Score = 92.8 bits (229), Expect = 2e-18
Identities = 95/348 (27%), Positives = 141/348 (40%), Gaps = 41/348 (11%)
Query: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
IW+IE V V+ A +G+FY D YI+L + G IY W G ++T D+ A SA
Sbjct: 398 IWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRH-GGRQGQIIYNWQGAQSTQDEVAASA 456
Query: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDND--ISYIEGGTASGFYTVEDTHYVTR 620
I L LG R G E + +F I Y G + G T + TR
Sbjct: 457 ILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS---TR 513
Query: 621 MYRVYGKKNIKLEPVPL--KGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEK 678
+++V V + K +L+ F+L Y+W G A+ + T A+
Sbjct: 514 LFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRV 573
Query: 679 INKNERKGKAEITLLVQGQELPEFWEALGGEP----SEIKKHVPEDFWPPQPKLYKVGLG 734
+ +A+ + +G E FWEALGG+ S K D PP +L+
Sbjct: 574 L-------RAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPP--RLFACSNK 624
Query: 735 LGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPR 794
+G R +E +P L+Q L T V +LD W VF+W+G+ S
Sbjct: 625 IG-----------------RFVIEEVPG-ELMQEDLATDDVMLLDTWDQVFVWVGKDSQE 666
Query: 795 LVRAAALKLGQEL--CGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 840
+ AL + +R R ++ +G E F F WDD
Sbjct: 667 EEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDD 714
>gi|189083772 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 258 bits (658), Expect = 3e-68
Identities = 221/795 (27%), Positives = 352/795 (44%), Gaps = 103/795 (12%)
Query: 485 LDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWE 544
+++ EF G+ PGL IW++E F V V +G F+ D Y++LKT +G+L ++
Sbjct: 3 VEHPEFLK--AGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYD 60
Query: 545 IYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGG 604
++YW+G E + D+ +AI V L +YL RE G ES FL F + + Y +GG
Sbjct: 61 LHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGG 120
Query: 605 TASGF-YTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQ 663
ASGF + V + V R+++V G++ ++ VP+ S + F+LD G +I+ W G+
Sbjct: 121 VASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSN 180
Query: 664 ATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGE---PSEIKKHVPED 720
+ KA ++ I NER G+A + + +G E + LG + P+ + ED
Sbjct: 181 SNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKED 240
Query: 721 FWPPQ-PKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD 779
+ KLYKV G G + +S+ + P Q L + +ILD
Sbjct: 241 AANRKLAKLYKVSNGAGTM-------SVSLVADENP---------FAQGALKSEDCFILD 284
Query: 780 CWSD--VFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKN 837
D +F+W G+++ R AALK + + P+ VS EG E +FK FKN
Sbjct: 285 HGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKN 344
Query: 838 WDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLM 897
W D D GLS + +++ D L S A A Q
Sbjct: 345 WRDPDQTD----------GLGLS-YLSSHIANVERVPFDAATLH------TSTAMAAQ-- 385
Query: 898 EEWNEDLDGMEG-FVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKE 956
++D G + + +EG + +G FY D Y+ L Y
Sbjct: 386 HGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNY---------------- 429
Query: 957 EKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKL 1016
+ G++G+ I+Y WQG + S + + L + + G
Sbjct: 430 -RHGGRQGQ-----------------IIYNWQGAQ-STQDEVAASAILTAQLDEELGGTP 470
Query: 1017 EVVRMTQQQENPKFLSHFKRK-FIIHRGKRKAVQGAQQPS---LYQIRTNGSALCTRCIQ 1072
R+ Q +E +S F K II++G G P+ L+Q+R N SA TR ++
Sbjct: 471 VQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRAN-SAGATRAVE 529
Query: 1073 INTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQ 1132
+ + LNS F+LK P Y WVG + E A+++L +
Sbjct: 530 VLPKAGALNSNDAFVLKTP-------SAAYLWVGTGASEAEKTGAQELLRVL---RAQPV 579
Query: 1133 VINEGEEPENFFWVGIGAQKPYD-----DDAEYMKH-TRLFRCSNEKGYFAVTEKCSDFC 1186
+ EG EP+ FW +G + Y D + H RLF CSN+ G F + E +
Sbjct: 580 QVAEGSEPDG-FWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELM 638
Query: 1187 QDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVR 1246
Q+DLA DD+MLLD +V++WVG + + E +L + + YI+ +R + +V+
Sbjct: 639 QEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIE-TDPANRDRRTPITVVK 697
Query: 1247 KGNEQHAFTRCFHAW 1261
+G E +F F W
Sbjct: 698 QGFEPPSFVGWFLGW 712
Score = 92.8 bits (229), Expect = 2e-18
Identities = 95/348 (27%), Positives = 141/348 (40%), Gaps = 41/348 (11%)
Query: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
IW+IE V V+ A +G+FY D YI+L + G IY W G ++T D+ A SA
Sbjct: 398 IWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRH-GGRQGQIIYNWQGAQSTQDEVAASA 456
Query: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDND--ISYIEGGTASGFYTVEDTHYVTR 620
I L LG R G E + +F I Y G + G T + TR
Sbjct: 457 ILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPAS---TR 513
Query: 621 MYRVYGKKNIKLEPVPL--KGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEK 678
+++V V + K +L+ F+L Y+W G A+ + T A+
Sbjct: 514 LFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRV 573
Query: 679 INKNERKGKAEITLLVQGQELPEFWEALGGEP----SEIKKHVPEDFWPPQPKLYKVGLG 734
+ +A+ + +G E FWEALGG+ S K D PP +L+
Sbjct: 574 L-------RAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPP--RLFACSNK 624
Query: 735 LGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPR 794
+G R +E +P L+Q L T V +LD W VF+W+G+ S
Sbjct: 625 IG-----------------RFVIEEVPG-ELMQEDLATDDVMLLDTWDQVFVWVGKDSQE 666
Query: 795 LVRAAALKLGQEL--CGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDD 840
+ AL + +R R ++ +G E F F WDD
Sbjct: 667 EEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDD 714
>gi|94721268 villin-like protein [Homo sapiens]
Length = 856
Score = 181 bits (460), Expect = 3e-45
Identities = 192/792 (24%), Positives = 321/792 (40%), Gaps = 115/792 (14%)
Query: 496 GQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGS--LNWEIYYWIGGEA 553
G GL IW EN V V E +G F+E CY++L + + +++YW+G +A
Sbjct: 9 GMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQA 68
Query: 554 TLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVE 613
+ + + L++ LG + RE G ES+ F F I Y +GG AS VE
Sbjct: 69 GAEAQGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVE 128
Query: 614 DTHY-VTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKA 672
+ + R+ + G+K++ V L S + +FLLD G + W G + ++S +
Sbjct: 129 TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARG 188
Query: 673 RLFAEKINKNER-KGKAEITLLVQGQELPEFWE----ALGGEPSEIKKHVPEDFWPPQPK 727
+ ER G+A+I ++ + P+ + LG ++ P
Sbjct: 189 LALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPSK------- 241
Query: 728 LYKVGLGLGYLELPQINYKL-SVEHKQRPKVEL-MPRMRLLQSLLDTRCVYILDCWS-DV 784
+L + N +L V K + V L + L Q LL YILD +
Sbjct: 242 --------DINQLQKANVRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKI 293
Query: 785 FIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTV 844
++W GR S R AA P + V +G E+ FK F+ W +
Sbjct: 294 YVWQGRMSSLQERKAAFSRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSE---- 349
Query: 845 DYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDL 904
R L S VK D K L QP LA +++++ +
Sbjct: 350 --KRRRNQKLGGRDKSIHVKLDVGK------------LHTQP--KLAAQLRMVDDGS--- 390
Query: 905 DGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEG 964
+E + ++ + + G +CY+ L Y
Sbjct: 391 GKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTY------------------------ 426
Query: 965 EEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQ 1024
Q Q I+Y WQG +A+ + S ++ + ++ G L +T
Sbjct: 427 ----------QRLGRVQYILYLWQGHQAT-ADEIEALNSNAEELDVMYGGVLVQEHVTMG 475
Query: 1025 QENPKFLSHFKRKFII------HRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSS 1078
E P FL+ F+ + +I H GK Q A L+Q++ S TR +++ +S
Sbjct: 476 SEPPHFLAIFQGQLVIFQERAGHHGKG---QSASTTRLFQVQGTDSH-NTRTMEVPARAS 531
Query: 1079 LLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGE 1138
LNS F+L + Y W G+ + D+ ++A ++ + + +++ + EG+
Sbjct: 532 SLNSSDIFLLV-------TASVCYLWFGKGCNGDQREMARVVVTVI--SRKNEETVLEGQ 582
Query: 1139 EPENFFWVGIGAQKPYDDDAEYMKHT-----RLFRCSNEKGYFAVTEKCSDFCQDDLADD 1193
EP + FW +G + PY + + RLF CS+ G + E F Q+DL
Sbjct: 583 EPPH-FWEALGGRAPYPSNKRLPEEVPSFQPRLFECSSHMGCLVLAE-VGFFSQEDLDKY 640
Query: 1194 DIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQ-HMRSKEHERPRRLRLVRKGNEQH 1252
DIMLLD QE+++W+G S E K ++ Q Y++ H + P + LV++G+E
Sbjct: 641 DIMLLDTWQEIFLWLGEAAS--EWKEAVAWGQEYLKTHPAGRSPATP--IVLVKQGHEPP 696
Query: 1253 AFTRCFHAWSAF 1264
F F W +
Sbjct: 697 TFIGWFFTWDPY 708
Score = 114 bits (285), Expect = 6e-25
Identities = 117/469 (24%), Positives = 189/469 (40%), Gaps = 52/469 (11%)
Query: 435 DSAQDDQAKQVLKGMSDVAQEKNKK--QEESADARAPSGKVRRWDQGLEKPRLDYSEFFT 492
D A+ KQ+ + S+ + K +++S + GK+ +P+L
Sbjct: 333 DGAESAAFKQLFRTWSEKRRRNQKLGGRDKSIHVKLDVGKLHT------QPKLAAQLRMV 386
Query: 493 EDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGE 552
+D + +W I++ V+ HG+ +CY+VL T+ G + + +Y W G +
Sbjct: 387 DDGSGK--VEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYTY-QRLGRVQYILYLWQGHQ 443
Query: 553 ATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTV 612
AT D+ +A L G MG E FL +F + + +G +
Sbjct: 444 ATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIFQGQLVIFQ--ERAGHHGK 501
Query: 613 EDTHYVTRMYRVYG--KKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTT 670
+ TR+++V G N + VP + +SL+ +FLL Y+W G
Sbjct: 502 GQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTASVCYLWFGKGCNGDQRE 561
Query: 671 KARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGE-PSEIKKHVPEDFWPPQPKLY 729
AR+ I++ K E T+L +GQE P FWEALGG P K +PE+ QP+L+
Sbjct: 562 MARVVVTVISR-----KNEETVL-EGQEPPHFWEALGGRAPYPSNKRLPEEVPSFQPRLF 615
Query: 730 KVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLG 789
+ +G L L ++ + Q LD + +LD W ++F+WLG
Sbjct: 616 ECSSHMGCLVLAEVGF-------------------FSQEDLDKYDIMLLDTWQEIFLWLG 656
Query: 790 RKSPRLVRAAALKLGQELCGMLHRPRHATVSRSL--EGTEAQVFKAKFKNWDDVLTVDYT 847
+ A A GQE R L +G E F F WD +
Sbjct: 657 EAASEWKEAVA--WGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHP 714
Query: 848 RNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQL 896
+ E V SP + + ++ A++ L L R P A A L
Sbjct: 715 SHKEVVDGSPAAASTI-------SEITAEVNNLRLSRWPGNGRAGAVAL 756
Score = 45.4 bits (106), Expect = 3e-04
Identities = 87/399 (21%), Positives = 154/399 (38%), Gaps = 91/399 (22%)
Query: 901 NEDLDGMEG----FVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKE 956
++ L GM+G ++ E +K +PE +G+F+ + CYV L VP
Sbjct: 4 SKGLPGMQGGLHIWISENRKMVPVPEGAYGNFFEEHCYVIL---HVP------------- 47
Query: 957 EKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKL 1016
+ +AT A +++W G++A + Q++ + G+
Sbjct: 48 ------QSPKATQGASSD---------LHYWVGKQAGAEA-QGAAEAFQQRLQDELGGQT 91
Query: 1017 EVVRMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQI--------RTNGSALCT 1068
+ R Q E+ F S+F+ I +G + + +L+ I R + SA
Sbjct: 92 VLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLFNIQRLLHIKGRKHVSA--- 148
Query: 1069 RCIQINTDSSLLNSEFCFIL---KVPFE--------SEDNQGIVYAWV--------GRAS 1109
++ + N F+L K+ + SE +G+ + GRA
Sbjct: 149 --TEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALTYSLRDRERGGGRAQ 206
Query: 1110 ---DPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMK-HTR 1165
DEAK A D++ M + ++V + A P D + K + R
Sbjct: 207 IGVVDDEAK-APDLMQIM-EAVLGRRV------------GSLRAATPSKDINQLQKANVR 252
Query: 1166 LFRCSNEKGYFAVTEKCS-DFCQDDLADDDIMLLDNGQ-EVYMWVGTQTSQVEIKLSLKA 1223
L+ + V E + QD L ++D +LD G ++Y+W G +S E K +
Sbjct: 253 LYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAFSR 312
Query: 1224 CQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWS 1262
+IQ +K + + +V G E AF + F WS
Sbjct: 313 AVGFIQ---AKGYPTYTNVEVVNDGAESAAFKQLFRTWS 348
>gi|14916473 scinderin isoform 2 [Homo sapiens]
Length = 468
Score = 170 bits (430), Expect = 9e-42
Identities = 146/509 (28%), Positives = 238/509 (46%), Gaps = 87/509 (17%)
Query: 769 LLDTRCVYILD--CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGT 826
LL C +ILD +F+W G+ + R AA+K +E ++ ++ + EG
Sbjct: 30 LLSEEC-FILDHGAAKQIFVWKGKDANPQERKAAMKTAEEFLQQMNYSKNTQIQVLPEGG 88
Query: 827 EAQVFKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQP 886
E +FK FK+W D QS G GKV EK Q+K +P
Sbjct: 89 ETPIFKQFFKDWRDKD------------QSDGF-GKVYV-TEKVAQIKQ------IPFDA 128
Query: 887 PMSLAEAEQLMEEWNEDLDG---MEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVP 943
L + Q+ + N DG +E + +E ++ + +G FY DCY+ L Y
Sbjct: 129 S-KLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTY--- 184
Query: 944 VEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFS 1003
G+ I+Y WQG A+ T F
Sbjct: 185 ------------------PRGQ-----------------IIYTWQGANATRDELTTSAF- 208
Query: 1004 LQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPS----LYQI 1059
L + + G+ +R++Q +E LS FK K +I + +G Q P+ L+Q+
Sbjct: 209 LTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPPTRLFQV 268
Query: 1060 RTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAED 1119
R N +++ TR ++++ D++ LNS F+LK+P N G Y WVG+ + +E K AE
Sbjct: 269 RRNLASI-TRIVEVDVDANSLNSNDVFVLKLP----QNSG--YIWVGKGASQEEEKGAEY 321
Query: 1120 ILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDD----DAEYMKHT-RLFRCSNEKG 1174
+ + + + I EGEEPE F W +G +K Y + + H RL+ CSN+ G
Sbjct: 322 VASVLKCKTLR---IQEGEEPEEF-WNSLGGKKDYQTSPLLETQAEDHPPRLYGCSNKTG 377
Query: 1175 YFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHMRSK 1234
F + E +F QDDLA+DD+MLLD +++++W+G ++VE K SLK+ ++Y++ S
Sbjct: 378 RFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESLKSAKMYLETDPSG 437
Query: 1235 EHERPRRLRLVRKGNEQHAFTRCFHAWSA 1263
+R + ++++G+E FT F W +
Sbjct: 438 RDKR-TPIVIIKQGHEPPTFTGWFLGWDS 465
Score = 91.3 bits (225), Expect = 5e-18
Identities = 89/350 (25%), Positives = 145/350 (41%), Gaps = 51/350 (14%)
Query: 503 IWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSA 562
IW++EN + V++ +G+FY DCYI+L T+ G + IY W G AT D+ SA
Sbjct: 153 IWRVENNGRIQVDQNSYGEFYGGDCYIILYTY--PRGQI---IYTWQGANATRDELTTSA 207
Query: 563 IHAVNLRNYLGAECRTVREEMGDESEEFLQVFDND--ISYIEGGTASGFYTVEDTHYVTR 620
V L LG + +R G E L +F + I Y G + G TR
Sbjct: 208 FLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKGGQAPAPP---TR 264
Query: 621 MYRVYGKKNI----KLEPVPLKGTSLDPRFVFLLDRGLDI-YVWRGAQATLSSTTKARLF 675
+++V ++N+ ++ V + SL+ VF+L + Y+W G A+ A
Sbjct: 265 LFQV--RRNLASITRIVEVDVDANSLNSNDVFVLKLPQNSGYIWVGKGASQEEEKGAEYV 322
Query: 676 AEKINKNERKGKAEITLLVQGQELPEFWEALGG----EPSEIKKHVPEDFWPPQPKLYKV 731
A + K + + +G+E EFW +LGG + S + + ED P+LY
Sbjct: 323 ASVL-------KCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLETQAEDH---PPRLYGC 372
Query: 732 GLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRK 791
G + +I + + Q L V +LD W +FIW+G+
Sbjct: 373 SNKTGRFVIEEIPGEFT------------------QDDLAEDDVMLLDAWEQIFIWIGKD 414
Query: 792 SPRLVRAAALKLGQEL--CGMLHRPRHATVSRSLEGTEAQVFKAKFKNWD 839
+ + + +LK + R + + +G E F F WD
Sbjct: 415 ANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWD 464
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 155 bits (392), Expect = 2e-37
Identities = 119/397 (29%), Positives = 186/397 (46%), Gaps = 57/397 (14%)
Query: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
P ++K +T L L L L LP E+ L L L++S N+LT+L L +L LR +
Sbjct: 116 PSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLD 175
Query: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145
R N L+ +P +++LD L+ L L N++T ++++N + +L++ N I +P +
Sbjct: 176 LRHNKLRE--IPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAE 233
Query: 146 LFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHL 205
+ L +L+ LD++ N+LE LP ++ + L L N LL + +++L L L
Sbjct: 234 IG-ELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP-DTIGNLSSLSRLGL 291
Query: 206 RSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTL-------------------- 245
R + S +P SL S L +++L N+++ +PE L +
Sbjct: 292 RYNRL--SAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVG 349
Query: 246 -PS----------------------------LRRLNLSSNQITELSLCIDQWVHVETLNL 276
PS L +LN+ NQ+T L L W + LNL
Sbjct: 350 GPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNL 409
Query: 277 SRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESL 336
+ NQLT +P + L L+ L L++N L LP G+G L L E N LE +P +
Sbjct: 410 ATNQLTKIPEDVSGLVSLEVLILSNNLLK--KLPHGLGNLRKLRELDLEENKLESLPNEI 467
Query: 337 CRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
L+KLVL N L TLP I LT + L + EN
Sbjct: 468 AYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGEN 504
Score = 104 bits (260), Expect = 5e-22
Identities = 97/355 (27%), Positives = 152/355 (42%), Gaps = 48/355 (13%)
Query: 27 ENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVA 86
+++K ++ L L + + LP E+ L L L V+HN L L E+ + + +
Sbjct: 209 KDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDL 268
Query: 87 RANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL 146
+ N L + +PD I L LS L L +N+L+ PR L + LNL +N+I T+P L
Sbjct: 269 QHNELLD--LPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESL 326
Query: 147 FINLTDLLYLDLSENRLE--------------SLPPQMRRL------VHLQTLVLNGNPL 186
+L L L L+ N + SL + R+ + + VL+ +
Sbjct: 327 LSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNM 386
Query: 187 LHAQLRQLP----AMTALQTLHLRSTQRTQ---------------------SNLPTSLEG 221
QL LP T++ L+L + Q T+ LP L
Sbjct: 387 KDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGN 446
Query: 222 LSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQL 281
L L ++DL N L +P + L L++L L++NQ+T L I ++ L L N L
Sbjct: 447 LRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLL 506
Query: 282 TSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESL 336
T LP I L L++LYLN N + LP + + L N L +P +
Sbjct: 507 THLPEEIGTLENLEELYLNDNP-NLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560
Score = 99.8 bits (247), Expect = 2e-20
Identities = 80/256 (31%), Positives = 120/256 (46%), Gaps = 30/256 (11%)
Query: 96 VPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLY 155
+P I +L L+ L L N+L P E+ N++ L LS NS+ ++P+ L NL L
Sbjct: 115 LPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSL-DNLKKLRM 173
Query: 156 LDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNL 215
LDL N+L +P + RL L TL L N + + + + ++ L L +R + Q L
Sbjct: 174 LDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVE-KDIKNLSKLSMLSIRENKIKQ--L 230
Query: 216 PTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLN 275
P + L NL +D++ N L +P+ E+ C + L+
Sbjct: 231 PAEIGELCNLITLDVAHNQLEHLPK-------------------EIGNC----TQITNLD 267
Query: 276 LSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPES 335
L N+L LP I LS L +L L N+L +P + K + LEE NNN+ +PES
Sbjct: 268 LQHNELLDLPDTIGNLSSLSRLGLRYNRL--SAIPRSLAKCSALEELNLENNNISTLPES 325
Query: 336 -LCRCPKLRKLVLNKN 350
L KL L L +N
Sbjct: 326 LLSSLVKLNSLTLARN 341
Score = 82.0 bits (201), Expect = 3e-15
Identities = 58/210 (27%), Positives = 99/210 (47%), Gaps = 21/210 (10%)
Query: 191 LRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRR 250
+++L ++ L ++R+ LP+S++ L+ L ++ L N L +P + L +L
Sbjct: 91 IKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMT 150
Query: 251 LNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKL------ 304
L LS N +T L +D + L+L N+L +PS + +L L LYL N++
Sbjct: 151 LALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKD 210
Query: 305 ---------------DFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNK 349
LP+ IG+L NL A+N LE +P+ + C ++ L L
Sbjct: 211 IKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQH 270
Query: 350 NHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
N L+ LP+ I L+ + L +R N +P
Sbjct: 271 NELLDLPDTIGNLSSLSRLGLRYNRLSAIP 300
>gi|63252913 gelsolin-like capping protein [Homo sapiens]
Length = 348
Score = 148 bits (374), Expect = 3e-35
Identities = 102/351 (29%), Positives = 168/351 (47%), Gaps = 29/351 (8%)
Query: 497 QLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLD 556
Q PGL +W++E PV V + G F+ D Y+VL ++ L + WIG +++ D
Sbjct: 17 QDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSHL----HLWIGQQSSRD 72
Query: 557 KKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVED-- 614
++ A+ AV+L LG RE G+ES+ F+ F + Y EGG S F+
Sbjct: 73 EQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGA 132
Query: 615 THYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARL 674
+ ++Y+V GKKNI+ L S + F+LD G +I+ W G ++ + KAR
Sbjct: 133 PAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARD 192
Query: 675 FAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPEDFWPPQPK-----LY 729
A I +ER+GKA++ ++ G+E E + LG +P+ + + ED + LY
Sbjct: 193 LALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALY 252
Query: 730 KVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD--CWSDVFIW 787
KV G + L ++ + P L+ L+ C ++LD ++IW
Sbjct: 253 KVSDATGQMNLTKV-------------ADSSP--FALELLISDDC-FVLDNGLCGKIYIW 296
Query: 788 LGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNW 838
GRK+ R AAL++ + + + V +G E+ +FK FK+W
Sbjct: 297 KGRKANEKERQAALQVAEGFISRMQYAPNTQVEILPQGHESPIFKQFFKDW 347
Score = 61.2 bits (147), Expect = 6e-09
Identities = 64/265 (24%), Positives = 112/265 (42%), Gaps = 36/265 (13%)
Query: 1020 RMTQQQENPKFLSHFKRKFIIHRG-------KRKAVQGAQQPSLYQIRTNGSALCTRCIQ 1072
R Q E+ F+S+F R G K A LYQ++ + T
Sbjct: 96 REVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIKKLYQVKGKKNIRATERA- 154
Query: 1073 INTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSK- 1131
+N DS N+ CFIL D ++AW G S+ E A D+ + D+
Sbjct: 155 LNWDS--FNTGDCFIL-------DLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGK 205
Query: 1132 ---QVINEGEEPENFFWV-----GIGAQKPYDD---DAEYMKHTRLFRCSNEKGYFAVTE 1180
+++ +GEEP V + P +D D + L++ S+ G +T+
Sbjct: 206 AQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTK 265
Query: 1181 KC--SDFCQDDLADDDIMLLDNGQ--EVYMWVGTQTSQVEIKLSLKACQVYIQHMRSKEH 1236
S F + L DD +LDNG ++Y+W G + ++ E + +L+ + +I M ++
Sbjct: 266 VADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFISRM---QY 322
Query: 1237 ERPRRLRLVRKGNEQHAFTRCFHAW 1261
++ ++ +G+E F + F W
Sbjct: 323 APNTQVEILPQGHESPIFKQFFKDW 347
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 147 bits (370), Expect = 8e-35
Identities = 115/367 (31%), Positives = 178/367 (48%), Gaps = 31/367 (8%)
Query: 15 LSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGE 74
L+GN K P+ + T LR + L R P+EL L LE + + N + + E
Sbjct: 149 LTGNHLK--CLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEE 206
Query: 75 LSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNL 134
+ L L+ +N+L +P + + LSVLDLSHN L P+ + M + L
Sbjct: 207 IGHLTGLQKFYMASNNLPV--LPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGL 264
Query: 135 SHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQL 194
S N ++ +P +L T L L L L L R LV+L+ L L+ N L H L Q+
Sbjct: 265 SGNRLEKVP-RLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPL-QI 322
Query: 195 PAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLS 254
A+ L+ L L + Q LP+ L LS L + L+ N+ PE + +L SL +L +
Sbjct: 323 CALKNLEVLGLDDNKIGQ--LPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIG 380
Query: 255 SNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIG 314
+Q +LT +P I KL LK+LY+ +N L++ LP +G
Sbjct: 381 QDQ--------------------GFKLTYVPEHIRKLQSLKELYIENNHLEY--LPVSLG 418
Query: 315 KLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENP 374
+ NLE +N L+ +P+++C+ L++L L N L LPE + L ++VL + +NP
Sbjct: 419 SMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNP 478
Query: 375 NLVMPPK 381
+ PPK
Sbjct: 479 -MEEPPK 484
Score = 122 bits (306), Expect = 2e-27
Identities = 110/399 (27%), Positives = 174/399 (43%), Gaps = 59/399 (14%)
Query: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
P + T L + L + +P+E+ L+ + L + NNL +L L L SL ++
Sbjct: 41 PLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLD 100
Query: 86 ARANSLKNSG----------------------VPDDIFK-LDDLSVLDLSHNQLTECPRE 122
N + +S +P IFK L L +L L+ N L P+E
Sbjct: 101 LSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKE 160
Query: 123 LENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLN 182
+ N + + L N + P +L + L L +DL EN++ ++P ++ L LQ +
Sbjct: 161 IVNQTKLREIYLKRNQFEVFPQELCV-LYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMA 219
Query: 183 GN--PLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPE 240
N P+L A L Q ++ L H ++P S L + ++ LS N L +VP
Sbjct: 220 SNNLPVLPASLCQCSQLSVLDLSH-----NLLHSIPKSFAELRKMTEIGLSGNRLEKVPR 274
Query: 241 --CLYT---------------------LPSLRRLNLSSNQITELSLCIDQWVHVETLNLS 277
C +T L +LR L+LS N + L I ++E L L
Sbjct: 275 LICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD 334
Query: 278 RNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANN---NLELVPE 334
N++ LPS + LSKLK L L N +F P + L +LE+ + L VPE
Sbjct: 335 DNKIGQLPSELGSLSKLKILGLTGN--EFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE 392
Query: 335 SLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
+ + L++L + NHL LP ++ + +EVLD R N
Sbjct: 393 HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHN 431
Score = 99.8 bits (247), Expect = 2e-20
Identities = 81/293 (27%), Positives = 133/293 (45%), Gaps = 52/293 (17%)
Query: 82 RAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDT 141
R A++ + +P +IF +L + L +NQ+ E P+E++ KN+ V
Sbjct: 26 RTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRV---------- 75
Query: 142 IPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQ 201
LYLD +N L SL P + L L++L L+ NP+ + L + + AL+
Sbjct: 76 ------------LYLD--KNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALR 121
Query: 202 TLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLY-TLPSLRRLNLSSNQITE 260
L L T DL +P ++ L L L L+ N +
Sbjct: 122 ELRLYQT-------------------------DLKEIPVVIFKNLHHLELLGLTGNHLKC 156
Query: 261 LSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLE 320
L I + + L RNQ P +C L L+ + L+ NK+ +P IG LT L+
Sbjct: 157 LPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKI--GAIPEEIGHLTGLQ 214
Query: 321 EFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
+F A+NNL ++P SLC+C +L L L+ N L ++P++ L ++ + + N
Sbjct: 215 KFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGN 267
Score = 56.2 bits (134), Expect = 2e-07
Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 2/153 (1%)
Query: 228 VDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSA 287
+D S LT +P ++T L ++L +NQI E+ I + ++ L L +N L SL A
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 288 ICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCR-CPKLRKLV 346
+ LS L+ L L+ N + F + L L E +L+ +P + + L L
Sbjct: 90 LGLLSSLESLDLSYNPI-FSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLG 148
Query: 347 LNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
L NHL LP+ I T++ + ++ N V P
Sbjct: 149 LTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
Score = 49.7 bits (117), Expect = 2e-05
Identities = 25/80 (31%), Positives = 44/80 (55%)
Query: 295 KKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVT 354
+ +++++ +P I T LEE NN +E +P+ + R +R L L+KN+L +
Sbjct: 26 RTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRS 85
Query: 355 LPEAIHFLTEIEVLDVRENP 374
L A+ L+ +E LD+ NP
Sbjct: 86 LCPALGLLSSLESLDLSYNP 105
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 144 bits (362), Expect = 7e-34
Identities = 105/362 (29%), Positives = 180/362 (49%), Gaps = 25/362 (6%)
Query: 32 MTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSL 91
+ L L L GL LP E+ L L L+VSHN+++ + E+S L ++R + N +
Sbjct: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI 246
Query: 92 KNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLT 151
+N P D+ L +L +L L N+L P L + K + VLNL +N + T P L L
Sbjct: 247 EN--FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF-LP 303
Query: 152 DLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPL--LHAQLRQLPAMTALQTLH----- 204
L+ LDL+ N + SLP ++R L +L+TL+++ N L L ++ QL + LQ
Sbjct: 304 KLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEV 363
Query: 205 -------------LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRL 251
L + N+P + + L + LS N LT +P+ ++ L +LR+L
Sbjct: 364 ISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKL 423
Query: 252 NLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPS 311
+++ N + +++ CI ++ +L S N +T +P I K+ K+ L+ NK+ + P
Sbjct: 424 HVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMY--FPL 481
Query: 312 GIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVR 371
G+ L +L N + +P + +L L L++N L+ E L ++ LD+
Sbjct: 482 GLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLG 541
Query: 372 EN 373
+N
Sbjct: 542 KN 543
Score = 142 bits (359), Expect = 2e-33
Identities = 119/424 (28%), Positives = 210/424 (49%), Gaps = 41/424 (9%)
Query: 3 ATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLS 62
A + ++ +L D K ++ LR L L++ L +PE+++ LE LS
Sbjct: 342 AVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLS 401
Query: 63 VSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRE 122
+S N LT L + L +LR + N++ + D I L+++ L+ S N +T+ P E
Sbjct: 402 LSDNKLTELPKYIHKLNNLRKLHVNRNNMVK--ITDCISHLNNICSLEFSGNIITDVPIE 459
Query: 123 LENAKNMLVLNLSHNSIDTIP-------------------NQLFINLT---DLLYLDLSE 160
++N + ++ + LS+N I P +++ ++++ LL+L+LSE
Sbjct: 460 IKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSE 519
Query: 161 NRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA----MTALQTLHLRSTQRTQSNLP 216
N+L L++L+ L L N Q++++PA M +L L L + P
Sbjct: 520 NKLLIFSEHFCSLINLKYLDLGKN-----QIKKIPASISNMISLHVLILCCNKF--ETFP 572
Query: 217 TSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNL 276
L L NL +DLS N L ++ + L +++LN SSNQ + + Q +E LN+
Sbjct: 573 RELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNI 632
Query: 277 SR---NQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVP 333
S+ +LT LP + +++LK+L +++N + +P IG+L NL A NN + +P
Sbjct: 633 SQIKGRKLTRLPGELSNMTQLKELDISNNAIR--EIPRNIGELRNLVSLHAYNNQISYLP 690
Query: 334 ESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWYNID 393
SL L++L L+ N+L LP AI+ + ++ ++ +NP L+ PP + + Y I
Sbjct: 691 PSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNP-LLRPPVEICKGKQLYTIA 749
Query: 394 FSLQ 397
LQ
Sbjct: 750 RYLQ 753
Score = 117 bits (292), Expect = 9e-26
Identities = 95/376 (25%), Positives = 171/376 (45%), Gaps = 27/376 (7%)
Query: 25 FPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAI 84
FP +++ + +L L L + L ++P+ L +L+ L L++ +N LTT L LP L ++
Sbjct: 249 FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISL 308
Query: 85 VARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPN 144
N + S +P +I +L +L L + HN+LT E+ + L L+ N ++ I +
Sbjct: 309 DLTGNLI--SSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISH 366
Query: 145 QLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLH 204
++ N +L L L +N L+++P ++ L+ L L+ N L + + + L+ LH
Sbjct: 367 KI-ENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELP-KYIHKLNNLRKLH 424
Query: 205 LRSTQRTQ---------------------SNLPTSLEGLSNLADVDLSCNDLTRVPECLY 243
+ + +++P ++ + ++LS N + P L
Sbjct: 425 VNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLC 484
Query: 244 TLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNK 303
L SL L+++ N I+E+ + I + L LS N+L C L LK YL+ K
Sbjct: 485 ALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLK--YLDLGK 542
Query: 304 LDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLT 363
+P+ I + +L + N E P LC L+ L L++N L + I L
Sbjct: 543 NQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLK 602
Query: 364 EIEVLDVRENPNLVMP 379
I+ L+ N + P
Sbjct: 603 GIQKLNFSSNQFIHFP 618
Score = 111 bits (278), Expect = 4e-24
Identities = 84/275 (30%), Positives = 139/275 (50%), Gaps = 5/275 (1%)
Query: 105 DLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLE 164
D ++L L E P+++ K + L L N I T +L L L L EN L
Sbjct: 142 DNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLS 201
Query: 165 SLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSN 224
SLP +++ L +L+ L ++ N + H +++ + ++ L + N P+ LE L N
Sbjct: 202 SLPSEIQLLHNLRILNVSHNHISHIP-KEISQLGNIRQLFFYNNYI--ENFPSDLECLGN 258
Query: 225 LADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSL 284
L + L N L +P+ L +L +LR LNL NQ+T + + +L+L+ N ++SL
Sbjct: 259 LEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSL 318
Query: 285 PSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRK 344
P I +L L+ L ++ NKL F L I +L ++E A+N LE++ + +LR
Sbjct: 319 PKEIRELKNLETLLMDHNKLTF--LAVEIFQLLKIKELQLADNKLEVISHKIENFRELRI 376
Query: 345 LVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
L+L+KN L +PE I +E L + +N +P
Sbjct: 377 LILDKNLLKNIPEKISCCAMLECLSLSDNKLTELP 411
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 142 bits (357), Expect = 3e-33
Identities = 112/357 (31%), Positives = 169/357 (47%), Gaps = 9/357 (2%)
Query: 24 YFPENV-KAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLR 82
Y PE + + SL L L+ L LPE+ L KL L +S N + L E+++ L
Sbjct: 26 YVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLV 85
Query: 83 AIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTI 142
+ N + +P+ I L V D S N LT P +N+ L+++ S+ ++
Sbjct: 86 ELDVSRNEIPE--IPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSL 143
Query: 143 PNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQT 202
P + NL +L L+L EN L LP + +L L+ L L N + + + A+ L+
Sbjct: 144 PENIG-NLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP-ESIGALLHLKD 201
Query: 203 LHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELS 262
L L Q S LP + L NL +D+S N L R+PE + L SL L +S N + +
Sbjct: 202 LWLDGNQL--SELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIP 259
Query: 263 LCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 322
I + + L + +N+LT LP A+ + L +L L N+L LP IGKL L
Sbjct: 260 DGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLT--LPKSIGKLKKLSNL 317
Query: 323 MAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
A N L +P+ + C L + N L +P + TE+ VLDV N L +P
Sbjct: 318 NADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP 374
Score = 107 bits (266), Expect = 9e-23
Identities = 87/291 (29%), Positives = 145/291 (49%), Gaps = 34/291 (11%)
Query: 15 LSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGE 74
LS ND PEN+ + +L L+L L YLP+ L L++LE L + +N + L
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNL--- 189
Query: 75 LSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNL 134
P+ I L L L L NQL+E P+E+ N KN+L L++
Sbjct: 190 ----------------------PESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDV 227
Query: 135 SHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQL 194
S N ++ +P ++ LT L L +S+N LE++P + +L L L ++ N +L QL
Sbjct: 228 SENRLERLPEEI-SGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQN-----RLTQL 281
Query: 195 P-AMTALQTL-HLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLN 252
P A+ ++L L T+ LP S+ L L++++ N L +P+ + SL
Sbjct: 282 PEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFC 341
Query: 253 LSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNK 303
+ N++T + + Q + L+++ N+L LP ++ L KLK L+L+ N+
Sbjct: 342 VRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQ 391
Score = 100 bits (248), Expect = 1e-20
Identities = 86/289 (29%), Positives = 136/289 (47%), Gaps = 38/289 (13%)
Query: 116 LTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVH 175
L C R +E+ ++ H S+ +P +++ L L L N+L LP Q +LV
Sbjct: 7 LWRCNRHVES------IDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK 60
Query: 176 LQTLVLNGNPLLHAQLRQLPAMTA--LQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCN 233
L+ L L+ N ++++LP A +Q + L ++ +P S+ L D S N
Sbjct: 61 LRKLGLSDN-----EIQRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGN 115
Query: 234 DLTRVPE----------------CLYTLP-------SLRRLNLSSNQITELSLCIDQWVH 270
LTR+PE L +LP +L L L N +T L + Q
Sbjct: 116 PLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRR 175
Query: 271 VETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLE 330
+E L+L N++ +LP +I L LK L+L+ N+L LP IG L NL + N LE
Sbjct: 176 LEELDLGNNEIYNLPESIGALLHLKDLWLDGNQL--SELPQEIGNLKNLLCLDVSENRLE 233
Query: 331 LVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
+PE + L LV+++N L T+P+ I L ++ +L V +N +P
Sbjct: 234 RLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLP 282
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 132 bits (331), Expect = 3e-30
Identities = 121/371 (32%), Positives = 182/371 (49%), Gaps = 33/371 (8%)
Query: 30 KAMTSLRWLKLNRTGLC----------------YLPEELAALQKLEHLSVSHNNLTTL-H 72
K ++LR L L G C LP A L +E L++ +N L +
Sbjct: 24 KLRSNLRQLTLTAAGACPGAGADALESPASPQLVLP---ANLGDIEALNLGNNGLEEVPE 80
Query: 73 GELSSLPSLRAIVARANSLKNSGVPDDIFKLDD-LSVLDLSHNQLTECPRELENA-KNML 130
G S+L SLR +V R N +P + +L L+ LD+SHN+LT E+ +A + +
Sbjct: 81 GLGSALGSLRVLVLRRNRFAR--LPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELR 138
Query: 131 VLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQ 190
LNLSHN + +P QL L L LD+S NRL LP + L L+TL ++ N L A
Sbjct: 139 KLNLSHNQLPALPAQLGA-LAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLT-AF 196
Query: 191 LRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRR 250
RQL + AL+ L + S + LP + L L + LS +L +P L SL
Sbjct: 197 PRQLLQLVALEELDVSSNRLR--GLPEDISALRALKILWLSGAELGTLPAGFCELASLES 254
Query: 251 LNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKL-DFDGL 309
L L +N + L ++ LNLS N P+A+ L+ L++LYL+ N+L L
Sbjct: 255 LMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSL 314
Query: 310 PSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLD 369
SG+G+L L NN + +P+S+ L +LVL N + LP+ L+ + +
Sbjct: 315 ISGLGRLLTL---WLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWK 371
Query: 370 VRENPNLVMPP 380
+++NP L+ PP
Sbjct: 372 IKDNP-LIQPP 381
Score = 89.0 bits (219), Expect = 3e-17
Identities = 79/288 (27%), Positives = 120/288 (41%), Gaps = 31/288 (10%)
Query: 2 EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHL 61
E L +R ++LS N P + A+ L L ++ L +LP+ L+ L +L L
Sbjct: 129 EVVSALRELRKLNLSHNQLPA--LPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTL 186
Query: 62 SVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPR 121
V HN LT +L L +L + +N L+ G+P+DI L L +L LS +L P
Sbjct: 187 DVDHNQLTAFPRQLLQLVALEELDVSSNRLR--GLPEDISALRALKILWLSGAELGTLPA 244
Query: 122 ELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVL 181
++ L L +N + +P Q F L L L+LS N E P + L L+ L L
Sbjct: 245 GFCELASLESLMLDNNGLQALPAQ-FSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYL 303
Query: 182 NGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPEC 241
+ N L +++P+ + GL L + L N + +P+
Sbjct: 304 SRNQL--------------------------TSVPSLISGLGRLLTLWLDNNRIRYLPDS 337
Query: 242 LYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAIC 289
+ L L L L NQI L Q V + N L P +C
Sbjct: 338 IVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVC 385
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 131 bits (329), Expect = 5e-30
Identities = 110/352 (31%), Positives = 168/352 (47%), Gaps = 17/352 (4%)
Query: 38 LKLNRTGLCYLPEELAALQK-LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGV 96
L + L +P+E+ +K LE L + N + L +L + SL + N L +
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT--L 84
Query: 97 PDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYL 156
P I L +L LD+S N + E P ++N K + ++ S N I +P+ F L +L L
Sbjct: 85 PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQL 143
Query: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA----MTALQTLHLRSTQRTQ 212
L++ LE LP RL LQ L L N QL+ LP +T L+ L L S + T+
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELREN-----QLKMLPKTMNRLTQLERLDLGSNEFTE 198
Query: 213 SNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVE 272
+P LE LS L + + N LT +P + +L L L++S N I + I +++
Sbjct: 199 --VPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
Query: 273 TLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELV 332
L LS N L LP I L + L ++ N+L + LP IG L ++EE + N +E +
Sbjct: 257 DLLLSSNSLQQLPETIGSLKNITTLKIDENQLMY--LPDSIGGLISVEELDCSFNEVEAL 314
Query: 333 PESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
P S+ + LR + N+L LP I I VL + N +P + D
Sbjct: 315 PSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGD 366
Score = 126 bits (317), Expect = 1e-28
Identities = 105/378 (27%), Positives = 182/378 (48%), Gaps = 31/378 (8%)
Query: 34 SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKN 93
+L L L+ + LP++L Q L LS+ N+LTTL +++L +LR + N ++
Sbjct: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE 106
Query: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
P++I L++++ S N +++ P N+ L L+ ++ +P F LT L
Sbjct: 107 --FPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-FGRLTKL 163
Query: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQS 213
L+L EN+L+ LP M RL L+ L L N L ++ L+ + + + T
Sbjct: 164 QILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRLTF- 221
Query: 214 NLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVET 273
+P + L L +D+S N++ V E + T +L+ L LSSN + +L I ++ T
Sbjct: 222 -IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITT 280
Query: 274 LNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANN------ 327
L + NQL LP +I L +++L + N+++ LPS IG+LTNL F A +N
Sbjct: 281 LKIDENQLMYLPDSIGGLISVEELDCSFNEVE--ALPSSIGQLTNLRTFAADHNYLQQLP 338
Query: 328 -----------------NLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDV 370
LE +PE + KL+ + L+ N L LP + L ++ + +
Sbjct: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWL 398
Query: 371 RENPNLVMPPKPADRAAE 388
+N + + P + +E
Sbjct: 399 SDNQSKPLIPLQKETDSE 416
Score = 119 bits (297), Expect = 2e-26
Identities = 84/279 (30%), Positives = 140/279 (50%), Gaps = 11/279 (3%)
Query: 104 DDLSVLDLSHNQLTECPRELEN-AKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENR 162
+ ++ LD SH L + P+E+ K + L L N I+ +P QLF N L L L +N
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDND 80
Query: 163 LESLPPQMRRLVHLQTLVLNGNPLLH--AQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE 220
L +LP + L++L+ L ++ N + ++ +T ++ ++ S LP
Sbjct: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVE-----ASVNPISKLPDGFS 135
Query: 221 GLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280
L NL + L+ L +P L L+ L L NQ+ L +++ +E L+L N+
Sbjct: 136 QLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNE 195
Query: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340
T +P + +LS LK+ ++++N+L F +P IG L L + NN+E+V E + C
Sbjct: 196 FTEVPEVLEQLSGLKEFWMDANRLTF--IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCE 253
Query: 341 KLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
L+ L+L+ N L LPE I L I L + EN + +P
Sbjct: 254 NLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
Score = 115 bits (287), Expect = 3e-25
Identities = 106/375 (28%), Positives = 176/375 (46%), Gaps = 27/375 (7%)
Query: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLT 69
+R +D+S N + FPEN+K L ++ + + LP+ + L L L ++ L
Sbjct: 94 LRELDVSKNGIQE--FPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151
Query: 70 TLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNM 129
L L L+ + R N LK +P + +L L LDL N+ TE P LE +
Sbjct: 152 FLPANFGRLTKLQILELRENQLKM--LPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGL 209
Query: 130 LVLNLSHNSIDTIPNQLFI-NLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLH 188
+ N + IP FI +L L YLD+S+N +E + + +LQ L+L+ N
Sbjct: 210 KEFWMDANRLTFIPG--FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN---- 263
Query: 189 AQLRQLP----AMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYT 244
L+QLP ++ + TL + Q LP S+ GL ++ ++D S N++ +P +
Sbjct: 264 -SLQQLPETIGSLKNITTLKIDENQLMY--LPDSIGGLISVEELDCSFNEVEALPSSIGQ 320
Query: 245 LPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKL 304
L +LR N + +L I W ++ L L N+L +LP + + KLK + L+ N+L
Sbjct: 321 LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Query: 305 DFDGLPSGIGKLTNLEE-FMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLP--EAIHF 361
LP KL L +++ N + L+P + +K+VL P E + F
Sbjct: 381 --KNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMF 438
Query: 362 LTEIEVLDVRENPNL 376
+++ E NP+L
Sbjct: 439 ISDNESF----NPSL 449
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 131 bits (329), Expect = 5e-30
Identities = 110/352 (31%), Positives = 168/352 (47%), Gaps = 17/352 (4%)
Query: 38 LKLNRTGLCYLPEELAALQK-LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGV 96
L + L +P+E+ +K LE L + N + L +L + SL + N L +
Sbjct: 27 LDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT--L 84
Query: 97 PDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYL 156
P I L +L LD+S N + E P ++N K + ++ S N I +P+ F L +L L
Sbjct: 85 PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDG-FSQLLNLTQL 143
Query: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA----MTALQTLHLRSTQRTQ 212
L++ LE LP RL LQ L L N QL+ LP +T L+ L L S + T+
Sbjct: 144 YLNDAFLEFLPANFGRLTKLQILELREN-----QLKMLPKTMNRLTQLERLDLGSNEFTE 198
Query: 213 SNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVE 272
+P LE LS L + + N LT +P + +L L L++S N I + I +++
Sbjct: 199 --VPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQ 256
Query: 273 TLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELV 332
L LS N L LP I L + L ++ N+L + LP IG L ++EE + N +E +
Sbjct: 257 DLLLSSNSLQQLPETIGSLKNITTLKIDENQLMY--LPDSIGGLISVEELDCSFNEVEAL 314
Query: 333 PESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
P S+ + LR + N+L LP I I VL + N +P + D
Sbjct: 315 PSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGD 366
Score = 126 bits (317), Expect = 1e-28
Identities = 105/378 (27%), Positives = 182/378 (48%), Gaps = 31/378 (8%)
Query: 34 SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKN 93
+L L L+ + LP++L Q L LS+ N+LTTL +++L +LR + N ++
Sbjct: 47 TLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQE 106
Query: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
P++I L++++ S N +++ P N+ L L+ ++ +P F LT L
Sbjct: 107 --FPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPAN-FGRLTKL 163
Query: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQS 213
L+L EN+L+ LP M RL L+ L L N L ++ L+ + + + T
Sbjct: 164 QILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVP-EVLEQLSGLKEFWMDANRLTF- 221
Query: 214 NLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVET 273
+P + L L +D+S N++ V E + T +L+ L LSSN + +L I ++ T
Sbjct: 222 -IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITT 280
Query: 274 LNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANN------ 327
L + NQL LP +I L +++L + N+++ LPS IG+LTNL F A +N
Sbjct: 281 LKIDENQLMYLPDSIGGLISVEELDCSFNEVE--ALPSSIGQLTNLRTFAADHNYLQQLP 338
Query: 328 -----------------NLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDV 370
LE +PE + KL+ + L+ N L LP + L ++ + +
Sbjct: 339 PEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWL 398
Query: 371 RENPNLVMPPKPADRAAE 388
+N + + P + +E
Sbjct: 399 SDNQSKPLIPLQKETDSE 416
Score = 119 bits (297), Expect = 2e-26
Identities = 84/279 (30%), Positives = 140/279 (50%), Gaps = 11/279 (3%)
Query: 104 DDLSVLDLSHNQLTECPRELEN-AKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENR 162
+ ++ LD SH L + P+E+ K + L L N I+ +P QLF N L L L +N
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLF-NCQSLHKLSLPDND 80
Query: 163 LESLPPQMRRLVHLQTLVLNGNPLLH--AQLRQLPAMTALQTLHLRSTQRTQSNLPTSLE 220
L +LP + L++L+ L ++ N + ++ +T ++ ++ S LP
Sbjct: 81 LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVE-----ASVNPISKLPDGFS 135
Query: 221 GLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQ 280
L NL + L+ L +P L L+ L L NQ+ L +++ +E L+L N+
Sbjct: 136 QLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNE 195
Query: 281 LTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCP 340
T +P + +LS LK+ ++++N+L F +P IG L L + NN+E+V E + C
Sbjct: 196 FTEVPEVLEQLSGLKEFWMDANRLTF--IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCE 253
Query: 341 KLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
L+ L+L+ N L LPE I L I L + EN + +P
Sbjct: 254 NLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
Score = 115 bits (287), Expect = 3e-25
Identities = 106/375 (28%), Positives = 176/375 (46%), Gaps = 27/375 (7%)
Query: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLT 69
+R +D+S N + FPEN+K L ++ + + LP+ + L L L ++ L
Sbjct: 94 LRELDVSKNGIQE--FPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151
Query: 70 TLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNM 129
L L L+ + R N LK +P + +L L LDL N+ TE P LE +
Sbjct: 152 FLPANFGRLTKLQILELRENQLKM--LPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGL 209
Query: 130 LVLNLSHNSIDTIPNQLFI-NLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLH 188
+ N + IP FI +L L YLD+S+N +E + + +LQ L+L+ N
Sbjct: 210 KEFWMDANRLTFIPG--FIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSN---- 263
Query: 189 AQLRQLP----AMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYT 244
L+QLP ++ + TL + Q LP S+ GL ++ ++D S N++ +P +
Sbjct: 264 -SLQQLPETIGSLKNITTLKIDENQLMY--LPDSIGGLISVEELDCSFNEVEALPSSIGQ 320
Query: 245 LPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKL 304
L +LR N + +L I W ++ L L N+L +LP + + KLK + L+ N+L
Sbjct: 321 LTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRL 380
Query: 305 DFDGLPSGIGKLTNLEE-FMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLP--EAIHF 361
LP KL L +++ N + L+P + +K+VL P E + F
Sbjct: 381 --KNLPFSFTKLQQLTAMWLSDNQSKPLIPLQKETDSETQKMVLTNYMFPQQPRTEDVMF 438
Query: 362 LTEIEVLDVRENPNL 376
+++ E NP+L
Sbjct: 439 ISDNESF----NPSL 449
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 129 bits (323), Expect = 2e-29
Identities = 104/343 (30%), Positives = 169/343 (49%), Gaps = 19/343 (5%)
Query: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLT 69
++ +D+S N + FPEN+K L ++ + + LP+ L L L ++ L
Sbjct: 94 LKELDISKNGVQE--FPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLE 151
Query: 70 TLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNM 129
L L LR + R N LK +P + KL L LDL +N+ E P L+ +N+
Sbjct: 152 FLPANFGRLVKLRILELRENHLKT--LPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNL 209
Query: 130 LVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHA 189
L + +N++ +P + L L+YLD+S+NR+E++ + L+ L+L+ N
Sbjct: 210 RELWMDNNALQVLPGSIG-KLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSN----- 263
Query: 190 QLRQLP----AMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTL 245
L+QLP + L TL + Q T LP ++ LS L + D SCN+L +P + L
Sbjct: 264 MLQQLPDSIGLLKKLTTLKVDDNQLTM--LPNTIGNLSLLEEFDCSCNELESLPSTIGYL 321
Query: 246 PSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLD 305
SLR L + N + EL I +V ++L N+L LP I ++ KL+ L L+ N+L
Sbjct: 322 HSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRL- 380
Query: 306 FDGLPSGIGKLTNLEE-FMAANNNLELVPESLCRCPKLRKLVL 347
LP KL L +++ N + L+P P+ ++ VL
Sbjct: 381 -KNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVL 422
Score = 125 bits (315), Expect = 2e-28
Identities = 105/343 (30%), Positives = 169/343 (49%), Gaps = 9/343 (2%)
Query: 38 LKLNRTGLCYLPEELAALQK-LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGV 96
L + L +P+E+ ++ LE L + N + L +L + +LR + N L N +
Sbjct: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSN--L 84
Query: 97 PDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYL 156
P I L +L LD+S N + E P ++ K + ++ S N I +P+ F L +L L
Sbjct: 85 PTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDG-FTQLLNLTQL 143
Query: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLP 216
L++ LE LP RLV L+ L L N L + + + L+ L L + + + LP
Sbjct: 144 YLNDAFLEFLPANFGRLVKLRILELRENHLKTLP-KSMHKLAQLERLDLGNNEFGE--LP 200
Query: 217 TSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNL 276
L+ + NL ++ + N L +P + L L L++S N+I + + I +E L L
Sbjct: 201 EVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLL 260
Query: 277 SRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESL 336
S N L LP +I L KL L ++ N+L LP+ IG L+ LEEF + N LE +P ++
Sbjct: 261 SSNMLQQLPDSIGLLKKLTTLKVDDNQLTM--LPNTIGNLSLLEEFDCSCNELESLPSTI 318
Query: 337 CRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
LR L +++N L LP I + V+ +R N +P
Sbjct: 319 GYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLP 361
Score = 120 bits (302), Expect = 6e-27
Identities = 105/367 (28%), Positives = 173/367 (47%), Gaps = 25/367 (6%)
Query: 34 SLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKN 93
+L L L+ + LP++L Q L LS+ N+L+ L ++SL +L+ + N ++
Sbjct: 47 TLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQE 106
Query: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
P++I L++++ S N +++ P N+ L L+ ++ +P F L L
Sbjct: 107 --FPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPAN-FGRLVKL 163
Query: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNGN-----PLLHAQLRQLPAM----TALQTL- 203
L+L EN L++LP M +L L+ L L N P + Q++ L + ALQ L
Sbjct: 164 RILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLP 223
Query: 204 ----------HLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNL 253
+L ++ + + G L D+ LS N L ++P+ + L L L +
Sbjct: 224 GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 283
Query: 254 SSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGI 313
NQ+T L I +E + S N+L SLPS I L L+ L ++ N L LP I
Sbjct: 284 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLP--ELPREI 341
Query: 314 GKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
G N+ +N LE +PE + + KLR L L+ N L LP + L E+ L + +N
Sbjct: 342 GSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
Query: 374 PNLVMPP 380
+ + P
Sbjct: 402 QSKALIP 408
Score = 107 bits (268), Expect = 6e-23
Identities = 83/277 (29%), Positives = 134/277 (48%), Gaps = 11/277 (3%)
Query: 106 LSVLDLSHNQLTECPRELENAKNML-VLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLE 164
+SVLD SH L + P+E+ N + L L L N I+ +P QLF N L L + +N L
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLS 82
Query: 165 SLPPQMRRLVHLQTLVL--NGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGL 222
+LP + LV+L+ L + NG ++ +T ++ ++ S LP L
Sbjct: 83 NLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIE-----ASVNPISKLPDGFTQL 137
Query: 223 SNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLT 282
NL + L+ L +P L LR L L N + L + + +E L+L N+
Sbjct: 138 LNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFG 197
Query: 283 SLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKL 342
LP + ++ L++L++++N L LP IGKL L + N +E V + C L
Sbjct: 198 ELPEVLDQIQNLRELWMDNNALQV--LPGSIGKLKMLVYLDMSKNRIETVDMDISGCEAL 255
Query: 343 RKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
L+L+ N L LP++I L ++ L V +N ++P
Sbjct: 256 EDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLP 292
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 126 bits (316), Expect = 2e-28
Identities = 112/349 (32%), Positives = 158/349 (45%), Gaps = 9/349 (2%)
Query: 26 PENV-KAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAI 84
PE + + SL L L+ L LP+ L L L +S N + L E+++ L +
Sbjct: 28 PEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVEL 87
Query: 85 VARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPN 144
N + +P+ I L + D S N L+ P +++ L L+ S+ +P
Sbjct: 88 DVSRNDIPE--IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG 145
Query: 145 QLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLH 204
+ NL +L+ L+L EN L+SLP + LV L+ L L GN L L A+ L+ L
Sbjct: 146 DVG-NLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDL-EVLPDTLGALPNLRELW 203
Query: 205 LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLC 264
L Q S LP L L L +D+S N L +P L L L L LS N + L
Sbjct: 204 LDRNQL--SALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDG 261
Query: 265 IDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMA 324
I Q + L + +N+L + AI L +L L N L LP +GKLT L
Sbjct: 262 IGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM--ALPRSLGKLTKLTNLNV 319
Query: 325 ANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
N+LE +P + C L L L N L LP + TE+ VLDV N
Sbjct: 320 DRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGN 368
Score = 125 bits (314), Expect = 3e-28
Identities = 102/307 (33%), Positives = 151/307 (49%), Gaps = 18/307 (5%)
Query: 80 SLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSI 139
SL ++ AN L+ +P F+L +L L LS N++ P E+ N ++ L++S N I
Sbjct: 37 SLEELLLDANQLRE--LPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDI 94
Query: 140 DTIPNQL-FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA-- 196
IP + F ++ D S N L LP +L L L LN L+ LP
Sbjct: 95 PEIPESIKFCKALEIA--DFSGNPLSRLPDGFTQLRSLAHLALND-----VSLQALPGDV 147
Query: 197 --MTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLS 254
+ L TL LR + +LP SL L L +DL NDL +P+ L LP+LR L L
Sbjct: 148 GNLANLVTLELR--ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
Query: 255 SNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIG 314
NQ++ L + + L++S N+L LP+ + L L L L+ N L LP GIG
Sbjct: 206 RNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL--RRLPDGIG 263
Query: 315 KLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENP 374
+L L N L V E++ C L +L+L +N L+ LP ++ LT++ L+V N
Sbjct: 264 QLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNH 323
Query: 375 NLVMPPK 381
+PP+
Sbjct: 324 LEALPPE 330
Score = 124 bits (312), Expect = 4e-28
Identities = 104/337 (30%), Positives = 164/337 (48%), Gaps = 9/337 (2%)
Query: 48 LPEELAALQK-LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDL 106
+PEE+ + LE L + N L L L +LR + N ++ +P ++ L
Sbjct: 27 VPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR--LPPEVANFMQL 84
Query: 107 SVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESL 166
LD+S N + E P ++ K + + + S N + +P+ F L L +L L++ L++L
Sbjct: 85 VELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDG-FTQLRSLAHLALNDVSLQAL 143
Query: 167 PPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLA 226
P + L +L TL L N LL + L + L+ L L LP +L L NL
Sbjct: 144 PGDVGNLANLVTLELREN-LLKSLPASLSFLVKLEQLDLGGNDLEV--LPDTLGALPNLR 200
Query: 227 DVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPS 286
++ L N L+ +P L L L L++S N++ EL + V + L LS+N L LP
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
Query: 287 AICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLV 346
I +L +L L ++ N+L + IG NL E + N L +P SL + KL L
Sbjct: 261 GIGQLKQLSILKVDQNRLC--EVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLN 318
Query: 347 LNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPA 383
+++NHL LP I + VL +R+N V+PP+ A
Sbjct: 319 VDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELA 355
Score = 108 bits (269), Expect = 4e-23
Identities = 99/320 (30%), Positives = 154/320 (48%), Gaps = 15/320 (4%)
Query: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH 72
+D+S ND PE++K +L + L LP+ L+ L HL+++ +L L
Sbjct: 87 LDVSRNDIPE--IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALP 144
Query: 73 GELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVL 132
G++ +L +L + R N LK+ +P + L L LDL N L P L N+ L
Sbjct: 145 GDVGNLANLVTLELRENLLKS--LPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
Query: 133 NLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLR 192
L N + +P +L NL L+ LD+SENRLE LP ++ LV L L+L+ N LR
Sbjct: 203 WLDRNQLSALPPELG-NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN-----LLR 256
Query: 193 QLP-AMTALQTLH-LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRR 250
+LP + L+ L L+ Q + ++ NL+++ L+ N L +P L L L
Sbjct: 257 RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTN 316
Query: 251 LNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLP 310
LN+ N + L I V + L+L N+L LP + ++L L + N+L LP
Sbjct: 317 LNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRL--QSLP 374
Query: 311 SGIGKLTNLEEFMAANNNLE 330
+ L NL+ A N +
Sbjct: 375 FALTHL-NLKALWLAENQAQ 393
Score = 33.5 bits (75), Expect = 1.3
Identities = 17/40 (42%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 941 WVP-VEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEED 979
W P + EEEE++E ++ E +E EE AE EE EE+
Sbjct: 653 WAPRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEE 692
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 126 bits (316), Expect = 2e-28
Identities = 112/349 (32%), Positives = 158/349 (45%), Gaps = 9/349 (2%)
Query: 26 PENV-KAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAI 84
PE + + SL L L+ L LP+ L L L +S N + L E+++ L +
Sbjct: 28 PEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVEL 87
Query: 85 VARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPN 144
N + +P+ I L + D S N L+ P +++ L L+ S+ +P
Sbjct: 88 DVSRNDIPE--IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPG 145
Query: 145 QLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLH 204
+ NL +L+ L+L EN L+SLP + LV L+ L L GN L L A+ L+ L
Sbjct: 146 DVG-NLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDL-EVLPDTLGALPNLRELW 203
Query: 205 LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLC 264
L Q S LP L L L +D+S N L +P L L L L LS N + L
Sbjct: 204 LDRNQL--SALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDG 261
Query: 265 IDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMA 324
I Q + L + +N+L + AI L +L L N L LP +GKLT L
Sbjct: 262 IGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLM--ALPRSLGKLTKLTNLNV 319
Query: 325 ANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVREN 373
N+LE +P + C L L L N L LP + TE+ VLDV N
Sbjct: 320 DRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGN 368
Score = 125 bits (314), Expect = 3e-28
Identities = 102/307 (33%), Positives = 151/307 (49%), Gaps = 18/307 (5%)
Query: 80 SLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSI 139
SL ++ AN L+ +P F+L +L L LS N++ P E+ N ++ L++S N I
Sbjct: 37 SLEELLLDANQLRE--LPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDI 94
Query: 140 DTIPNQL-FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPA-- 196
IP + F ++ D S N L LP +L L L LN L+ LP
Sbjct: 95 PEIPESIKFCKALEIA--DFSGNPLSRLPDGFTQLRSLAHLALND-----VSLQALPGDV 147
Query: 197 --MTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLS 254
+ L TL LR + +LP SL L L +DL NDL +P+ L LP+LR L L
Sbjct: 148 GNLANLVTLELR--ENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLD 205
Query: 255 SNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIG 314
NQ++ L + + L++S N+L LP+ + L L L L+ N L LP GIG
Sbjct: 206 RNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLL--RRLPDGIG 263
Query: 315 KLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENP 374
+L L N L V E++ C L +L+L +N L+ LP ++ LT++ L+V N
Sbjct: 264 QLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNH 323
Query: 375 NLVMPPK 381
+PP+
Sbjct: 324 LEALPPE 330
Score = 124 bits (312), Expect = 4e-28
Identities = 104/337 (30%), Positives = 164/337 (48%), Gaps = 9/337 (2%)
Query: 48 LPEELAALQK-LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDL 106
+PEE+ + LE L + N L L L +LR + N ++ +P ++ L
Sbjct: 27 VPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQR--LPPEVANFMQL 84
Query: 107 SVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESL 166
LD+S N + E P ++ K + + + S N + +P+ F L L +L L++ L++L
Sbjct: 85 VELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDG-FTQLRSLAHLALNDVSLQAL 143
Query: 167 PPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLA 226
P + L +L TL L N LL + L + L+ L L LP +L L NL
Sbjct: 144 PGDVGNLANLVTLELREN-LLKSLPASLSFLVKLEQLDLGGNDLEV--LPDTLGALPNLR 200
Query: 227 DVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPS 286
++ L N L+ +P L L L L++S N++ EL + V + L LS+N L LP
Sbjct: 201 ELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
Query: 287 AICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLV 346
I +L +L L ++ N+L + IG NL E + N L +P SL + KL L
Sbjct: 261 GIGQLKQLSILKVDQNRLC--EVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLN 318
Query: 347 LNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPA 383
+++NHL LP I + VL +R+N V+PP+ A
Sbjct: 319 VDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELA 355
Score = 108 bits (269), Expect = 4e-23
Identities = 99/320 (30%), Positives = 154/320 (48%), Gaps = 15/320 (4%)
Query: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH 72
+D+S ND PE++K +L + L LP+ L+ L HL+++ +L L
Sbjct: 87 LDVSRNDIPE--IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALP 144
Query: 73 GELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVL 132
G++ +L +L + R N LK+ +P + L L LDL N L P L N+ L
Sbjct: 145 GDVGNLANLVTLELRENLLKS--LPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
Query: 133 NLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLR 192
L N + +P +L NL L+ LD+SENRLE LP ++ LV L L+L+ N LR
Sbjct: 203 WLDRNQLSALPPELG-NLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN-----LLR 256
Query: 193 QLP-AMTALQTLH-LRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRR 250
+LP + L+ L L+ Q + ++ NL+++ L+ N L +P L L L
Sbjct: 257 RLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTN 316
Query: 251 LNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLP 310
LN+ N + L I V + L+L N+L LP + ++L L + N+L LP
Sbjct: 317 LNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRL--QSLP 374
Query: 311 SGIGKLTNLEEFMAANNNLE 330
+ L NL+ A N +
Sbjct: 375 FALTHL-NLKALWLAENQAQ 393
Score = 33.5 bits (75), Expect = 1.3
Identities = 17/40 (42%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 941 WVP-VEYEEEEKKEDKEEKAEGKEGEEATAEAEEKQPEED 979
W P + EEEE++E ++ E +E EE AE EE EE+
Sbjct: 653 WAPRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEE 692
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 115 bits (288), Expect = 3e-25
Identities = 96/359 (26%), Positives = 178/359 (49%), Gaps = 27/359 (7%)
Query: 27 ENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVA 86
++++ + +L L ++ L LP + L+ L+ L+VSHN L L E+++L +L+ +
Sbjct: 99 DDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYL 158
Query: 87 RANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL 146
+ N L + + + +L +L LDLS+N LT P + +++ LNLS N + ++P ++
Sbjct: 159 QHNEL--TCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEI 216
Query: 147 FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLR 206
+ L +LD + N LE++PP++ + L+ L L N L L + P+ + L+ LH+
Sbjct: 217 -NRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRF--LPEFPSCSLLKELHVG 273
Query: 207 STQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCID 266
Q + L+ L+++ +DL N L VP+ + L SL RL+LS+N I+ L +
Sbjct: 274 ENQ-IEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLG 332
Query: 267 QWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDG-------------LPS-- 311
+H++ L L N L ++ I + L +K+ DG LPS
Sbjct: 333 N-LHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSES 391
Query: 312 --GIGKLTNLEEFMAANNNLELVPESLCRCPK---LRKLVLNKNHLVTLPEAIHFLTEI 365
I + L+ ++ L+P+ + K + + +KN L +P+ + L E+
Sbjct: 392 RVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEM 450
Score = 111 bits (278), Expect = 4e-24
Identities = 108/434 (24%), Positives = 192/434 (44%), Gaps = 71/434 (16%)
Query: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH 72
+++S N K PE + + +L+ L L L + E L LE L +S+N+LTT+
Sbjct: 133 LNVSHNKLK--ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVP 190
Query: 73 GELSSLPSLRAIVARANSLKN---------------------SGVPDDIFKLDDLSVLDL 111
SSL SL + +N LK+ +P ++ ++ L +L L
Sbjct: 191 ASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYL 250
Query: 112 SHNQLTECP-----------------------RELENAKNMLVLNLSHNSIDTIPNQLFI 148
N+L P L++ ++LVL+L N + ++P+++ +
Sbjct: 251 RRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL 310
Query: 149 NLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLR-- 206
L L LDLS N + SLP + L HL+ L L GNPL + + T +LR
Sbjct: 311 -LRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSK 368
Query: 207 ----------STQRTQSNLPT----SLEGLSNLADVDLSCNDLTRVPECLYTLPS---LR 249
S T LP+ ++ + L +D S T +P+ ++ +
Sbjct: 369 IKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVT 428
Query: 250 RLNLSSNQITEL-SLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDG 308
+N S NQ+ E+ ++ V ++LS N+L+ + +C L KL L L +N L +
Sbjct: 429 SINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFL--NS 486
Query: 309 LPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTL-PEAIHFLTEIEV 367
LP + L L+ + N +++PE L R L ++++ N + ++ P+ + + +
Sbjct: 487 LPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTT 546
Query: 368 LDVRENPNLVMPPK 381
LD++ N L +PP+
Sbjct: 547 LDLQNNDLLQIPPE 560
Score = 106 bits (265), Expect = 1e-22
Identities = 106/405 (26%), Positives = 180/405 (44%), Gaps = 75/405 (18%)
Query: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH 72
+DLS N P + +++SL L L+ L LP E+ +++L+HL + N L T+
Sbjct: 179 LDLSNNHLTT--VPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIP 236
Query: 73 GELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRE-LENAKNMLV 131
EL+ + SL + R N L+ + L L + NQ+ E L++ ++LV
Sbjct: 237 PELAGMESLELLYLRRNKLR---FLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILV 293
Query: 132 LNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPL----- 186
L+L N + ++P+++ + L L LDLS N + SLP + L HL+ L L GNPL
Sbjct: 294 LDLRDNKLKSVPDEIIL-LRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRR 351
Query: 187 -------------LHAQLRQ-----------------------LPAMTALQTLHLRSTQR 210
L ++++ + A+ L+ L Q
Sbjct: 352 EIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQA 411
Query: 211 T----------QSNLPTSLEGLSN---------------LADVDLSCNDLTRVPECLYTL 245
T +SN+ TS+ N ++DVDLS N L+ + L L
Sbjct: 412 TLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVL 471
Query: 246 PSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLD 305
L L+L +N + L ++ V ++T+NLS N+ LP + ++ L+ + +++N++
Sbjct: 472 QKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVG 531
Query: 306 FDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKN 350
P + + NL NN+L +P L C LR L+L+ N
Sbjct: 532 SVD-PQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
Score = 104 bits (259), Expect = 6e-22
Identities = 87/297 (29%), Positives = 142/297 (47%), Gaps = 31/297 (10%)
Query: 84 IVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIP 143
I AN + G + ++ DL+ L +S+N+L +L + VL++ N + ++P
Sbjct: 62 IPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLP 121
Query: 144 NQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTL 203
+ + L +L L++S N+L+ LP ++ L +L+ L L N L
Sbjct: 122 SAI-RELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNEL----------------- 163
Query: 204 HLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSL 263
+ + E LSNL D+DLS N LT VP +L SL RLNLSSN++ L
Sbjct: 164 ---------TCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPA 214
Query: 264 CIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFM 323
I++ ++ L+ + N L ++P + + L+ LYL NKL F LP + L+E
Sbjct: 215 EINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRF--LPE-FPSCSLLKELH 271
Query: 324 AANNNLELV-PESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMP 379
N +E++ E L + L L N L ++P+ I L +E LD+ N +P
Sbjct: 272 VGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP 328
Score = 101 bits (251), Expect = 5e-21
Identities = 85/264 (32%), Positives = 135/264 (51%), Gaps = 18/264 (6%)
Query: 58 LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLT 117
L L +S+N L +L +L LP+L + N L + +P I +L++L L++SHN+L
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQL--TSLPSAIRELENLQKLNVSHNKLK 141
Query: 118 ECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQ 177
P E+ N +N+ L L HN + I ++ F L++L LDLS N L ++P L L
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCI-SEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLV 200
Query: 178 TLVLNGNPLLHAQLRQLPA-MTALQTL-HLRSTQRTQSNLPTSLEGLSNLADVDLSCNDL 235
L L+ N +L+ LPA + ++ L HL +P L G+ +L + L N L
Sbjct: 201 RLNLSSN-----ELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKL 255
Query: 236 TRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVET---LNLSRNQLTSLPSAICKLS 292
+PE + L+ L++ NQI L + H+ + L+L N+L S+P I L
Sbjct: 256 RFLPE-FPSCSLLKELHVGENQIEMLE--AEHLKHLNSILVLDLRDNKLKSVPDEIILLR 312
Query: 293 KLKKLYLNSNKLDFDGLPSGIGKL 316
L++L L++N D LP +G L
Sbjct: 313 SLERLDLSNN--DISSLPYSLGNL 334
Score = 90.9 bits (224), Expect = 7e-18
Identities = 75/283 (26%), Positives = 132/283 (46%), Gaps = 30/283 (10%)
Query: 92 KNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLT 151
K + DD+ L L+VLD+ NQLT P + +N+ LN+SHN + +P ++ NL
Sbjct: 93 KLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEI-TNLR 151
Query: 152 DLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRT 211
+L L L N L + +L +L+ L L+ N L
Sbjct: 152 NLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHL------------------------- 186
Query: 212 QSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHV 271
+ +P S LS+L ++LS N+L +P + + L+ L+ +SN + + + +
Sbjct: 187 -TTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESL 245
Query: 272 ETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLEL 331
E L L RN+L LP S LK+L++ N+++ + L ++ +N L+
Sbjct: 246 ELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEMLE-AEHLKHLNSILVLDLRDNKLKS 303
Query: 332 VPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENP 374
VP+ + L +L L+ N + +LP ++ L ++ L + NP
Sbjct: 304 VPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNP 345
Score = 86.7 bits (213), Expect = 1e-16
Identities = 60/186 (32%), Positives = 97/186 (52%), Gaps = 4/186 (2%)
Query: 223 SNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLT 282
++L + +S N L + + L LP+L L++ NQ+T L I + +++ LN+S N+L
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 283 SLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKL 342
LP I L LK LYL N+L + G +L+NLE+ +NN+L VP S L
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTC--ISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSL 199
Query: 343 RKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRL 402
+L L+ N L +LP I+ + ++ LD N +PP+ A E + + +N+LR
Sbjct: 200 VRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELA--GMESLELLYLRRNKLRF 257
Query: 403 AGASPA 408
P+
Sbjct: 258 LPEFPS 263
Score = 67.0 bits (162), Expect = 1e-10
Identities = 41/149 (27%), Positives = 79/149 (53%), Gaps = 3/149 (2%)
Query: 38 LKLNRTGLCYLPEELAALQKL-EHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGV 96
+ ++ LC +P+ + L+++ + +S N L+ + EL L L + R N L + +
Sbjct: 430 INFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS--L 487
Query: 97 PDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYL 156
P+++ L L ++LS N+ P L + + +S+N + ++ Q + +L L
Sbjct: 488 PEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTL 547
Query: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNP 185
DL N L +PP++ V+L+TL+L+GNP
Sbjct: 548 DLQNNDLLQIPPELGNCVNLRTLLLDGNP 576
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 112 bits (281), Expect = 2e-24
Identities = 105/364 (28%), Positives = 171/364 (46%), Gaps = 38/364 (10%)
Query: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
P+NV +T + L L LP ++ L L+ L V H++L H L+ L
Sbjct: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLE------ 486
Query: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSH----NSIDT 141
++L +L L ++ + PR + + KN+ L LS + T
Sbjct: 487 ------------------ENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLST 528
Query: 142 IPNQLFINLTDL--LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTA 199
+ + F +L +L LYL S +R+ + + L LQ L L+ L L M
Sbjct: 529 MQLEGFQDLKNLRTLYLKSSLSRIPQVVTDL--LPSLQKLSLDNEGSKLVVLNNLKKMVN 586
Query: 200 LQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECL--YTLPSLRRLNLSSNQ 257
L++L L S + +P S+ L+NL ++DL N+L V E + L +L L L N
Sbjct: 587 LKSLELISCDLER--IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNN 644
Query: 258 ITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLT 317
I + I ++E L+L N + +LP + +KL L L+ N L F +P I L+
Sbjct: 645 IAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTF--IPEEIQYLS 702
Query: 318 NLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLV 377
NL+ F NNN+E++P+ L +C KL+ L+L KN L+ L + L+ + L++ N
Sbjct: 703 NLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLET 762
Query: 378 MPPK 381
+PP+
Sbjct: 763 LPPE 766
Score = 90.5 bits (223), Expect = 9e-18
Identities = 83/313 (26%), Positives = 142/313 (45%), Gaps = 50/313 (15%)
Query: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
+G+PD++F+L ++ VL L + P + N+ L + H+S+ L +L
Sbjct: 430 NGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENL 489
Query: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNG----NPLLHAQLRQLPAMTALQTLHLRST- 208
L L + +P + L +L+ L L+G L QL + L+TL+L+S+
Sbjct: 490 KILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSL 549
Query: 209 ---QRTQSNLPTSLEGLS------------------NLADVDLSCNDLTRVPECLYTLPS 247
+ ++L SL+ LS NL ++L DL R+P +++L +
Sbjct: 550 SRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNN 609
Query: 248 LRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFD 307
L L+L N + + I + H++ L+ L L N + +
Sbjct: 610 LHELDLRENNLKTVEEIIS-FQHLQNLSC--------------------LKLWHNNIAY- 647
Query: 308 GLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEV 367
+P+ IG L+NLE+ +NN+E +P L C KL L L+ NHL +PE I +L+ ++
Sbjct: 648 -IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
Query: 368 LDVRENPNLVMPP 380
V N N+ M P
Sbjct: 707 FAVTNN-NIEMLP 718
Score = 73.9 bits (180), Expect = 9e-13
Identities = 80/298 (26%), Positives = 138/298 (46%), Gaps = 16/298 (5%)
Query: 23 GYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLR 82
G P V + +L+ L L+ C LPE+L+ +Q + + L LS +P +
Sbjct: 500 GKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVV 556
Query: 83 AIVA---RANSLKNSG----VPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLS 135
+ + SL N G V +++ K+ +L L+L L P + + N+ L+L
Sbjct: 557 TDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLR 616
Query: 136 HNSIDTIPNQL-FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQL 194
N++ T+ + F +L +L L L N + +P Q+ L +L+ L L+ N + + L QL
Sbjct: 617 ENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPL-QL 675
Query: 195 PAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLS 254
T L L L T +P ++ LSNL ++ N++ +P+ L+ L+ L L
Sbjct: 676 FLCTKLHYLDLSYNHLTF--IPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLG 733
Query: 255 SNQITELSLCIDQWVHVETLNLSRNQLTSLPSAI--CKLSKLKKLYLNSNKLDFDGLP 310
N + LS + + ++ L L N L +LP + C+ K L + N L+ LP
Sbjct: 734 KNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLP 791
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 112 bits (281), Expect = 2e-24
Identities = 105/364 (28%), Positives = 171/364 (46%), Gaps = 38/364 (10%)
Query: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
P+NV +T + L L LP ++ L L+ L V H++L H L+ L
Sbjct: 433 PDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLE------ 486
Query: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSH----NSIDT 141
++L +L L ++ + PR + + KN+ L LS + T
Sbjct: 487 ------------------ENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLST 528
Query: 142 IPNQLFINLTDL--LYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTA 199
+ + F +L +L LYL S +R+ + + L LQ L L+ L L M
Sbjct: 529 MQLEGFQDLKNLRTLYLKSSLSRIPQVVTDL--LPSLQKLSLDNEGSKLVVLNNLKKMVN 586
Query: 200 LQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECL--YTLPSLRRLNLSSNQ 257
L++L L S + +P S+ L+NL ++DL N+L V E + L +L L L N
Sbjct: 587 LKSLELISCDLER--IPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNN 644
Query: 258 ITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLT 317
I + I ++E L+L N + +LP + +KL L L+ N L F +P I L+
Sbjct: 645 IAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTF--IPEEIQYLS 702
Query: 318 NLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLV 377
NL+ F NNN+E++P+ L +C KL+ L+L KN L+ L + L+ + L++ N
Sbjct: 703 NLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLET 762
Query: 378 MPPK 381
+PP+
Sbjct: 763 LPPE 766
Score = 90.5 bits (223), Expect = 9e-18
Identities = 83/313 (26%), Positives = 142/313 (45%), Gaps = 50/313 (15%)
Query: 94 SGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDL 153
+G+PD++F+L ++ VL L + P + N+ L + H+S+ L +L
Sbjct: 430 NGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENL 489
Query: 154 LYLDLSENRLESLPPQMRRLVHLQTLVLNG----NPLLHAQLRQLPAMTALQTLHLRST- 208
L L + +P + L +L+ L L+G L QL + L+TL+L+S+
Sbjct: 490 KILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSL 549
Query: 209 ---QRTQSNLPTSLEGLS------------------NLADVDLSCNDLTRVPECLYTLPS 247
+ ++L SL+ LS NL ++L DL R+P +++L +
Sbjct: 550 SRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNN 609
Query: 248 LRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFD 307
L L+L N + + I + H++ L+ L L N + +
Sbjct: 610 LHELDLRENNLKTVEEIIS-FQHLQNLSC--------------------LKLWHNNIAY- 647
Query: 308 GLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEV 367
+P+ IG L+NLE+ +NN+E +P L C KL L L+ NHL +PE I +L+ ++
Sbjct: 648 -IPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQY 706
Query: 368 LDVRENPNLVMPP 380
V N N+ M P
Sbjct: 707 FAVTNN-NIEMLP 718
Score = 73.9 bits (180), Expect = 9e-13
Identities = 80/298 (26%), Positives = 138/298 (46%), Gaps = 16/298 (5%)
Query: 23 GYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLR 82
G P V + +L+ L L+ C LPE+L+ +Q + + L LS +P +
Sbjct: 500 GKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVV 556
Query: 83 AIVA---RANSLKNSG----VPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLS 135
+ + SL N G V +++ K+ +L L+L L P + + N+ L+L
Sbjct: 557 TDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLR 616
Query: 136 HNSIDTIPNQL-FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQL 194
N++ T+ + F +L +L L L N + +P Q+ L +L+ L L+ N + + L QL
Sbjct: 617 ENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPL-QL 675
Query: 195 PAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLS 254
T L L L T +P ++ LSNL ++ N++ +P+ L+ L+ L L
Sbjct: 676 FLCTKLHYLDLSYNHLTF--IPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLG 733
Query: 255 SNQITELSLCIDQWVHVETLNLSRNQLTSLPSAI--CKLSKLKKLYLNSNKLDFDGLP 310
N + LS + + ++ L L N L +LP + C+ K L + N L+ LP
Sbjct: 734 KNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLP 791
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 108 bits (270), Expect = 3e-23
Identities = 80/229 (34%), Positives = 122/229 (53%), Gaps = 13/229 (5%)
Query: 167 PPQMRRLVHLQTLVLNGNPLLHAQLRQLP-AMTALQTLHLRSTQRTQS----------NL 215
P Q+ ++ L+ LL A L QLP +++ L++L L+ QR + NL
Sbjct: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
Query: 216 PTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLN 275
P L GL++LA +DLS N L +P C+ + L L LS N ++EL + + L
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
Query: 276 LSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPES 335
++ N+L +LP A+ LS L++L L+ N L D LP IG L +L E A+N L+ +P S
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLL--DTLPPEIGGLGSLLELNLASNRLQSLPAS 235
Query: 336 LCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
L LR LVL+ N L ++P + L + LD+R+N +PP+ D
Sbjct: 236 LAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
Score = 82.8 bits (203), Expect = 2e-15
Identities = 98/332 (29%), Positives = 147/332 (44%), Gaps = 33/332 (9%)
Query: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPE------ELAALQKLEHLSV 63
V G +L G ++ +L +L NR L P L Q L+ L V
Sbjct: 5 VEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQLLQV 64
Query: 64 SHNNLTT------LHGELSSLPS----LRAIVARANSLKNS----------GVPDDIFKL 103
L+T L L+ LP LR++V + +++ +P + L
Sbjct: 65 EFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGL 124
Query: 104 DDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRL 163
L+ LDLS N L P + + + L LSHN + +P L L L +L ++ NRL
Sbjct: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA-LPALTFLTVTHNRL 183
Query: 164 ESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLS 223
++LPP + L LQ L L+ N LL ++ + +L L+L S R QS LP SL GL
Sbjct: 184 QTLPPALGALSTLQRLDLSQN-LLDTLPPEIGGLGSLLELNLAS-NRLQS-LPASLAGLR 240
Query: 224 NLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITEL--SLCIDQWVHVETLNLSRNQL 281
+L + L N L VP L LP L RL+L NQ+ +L L +V ++ L
Sbjct: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300
Query: 282 TSLPSAICKL-SKLKKLYLNSNKLDFDGLPSG 312
+ S + L ++ +L+L S+ F P G
Sbjct: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQG 332
Score = 61.2 bits (147), Expect = 6e-09
Identities = 44/125 (35%), Positives = 70/125 (56%), Gaps = 4/125 (3%)
Query: 2 EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHL 61
EA G LP + + ++ N + P + A+++L+ L L++ L LP E+ L L L
Sbjct: 165 EALGALPALTFLTVTHNRLQT--LPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
Query: 62 SVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPR 121
+++ N L +L L+ L SLR +V +N L + VP D+ +L L+ LDL NQL + P
Sbjct: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLL--ASVPADLARLPLLTRLDLRDNQLRDLPP 280
Query: 122 ELENA 126
EL +A
Sbjct: 281 ELLDA 285
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 108 bits (270), Expect = 3e-23
Identities = 80/229 (34%), Positives = 122/229 (53%), Gaps = 13/229 (5%)
Query: 167 PPQMRRLVHLQTLVLNGNPLLHAQLRQLP-AMTALQTLHLRSTQRTQS----------NL 215
P Q+ ++ L+ LL A L QLP +++ L++L L+ QR + NL
Sbjct: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNL 117
Query: 216 PTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLN 275
P L GL++LA +DLS N L +P C+ + L L LS N ++EL + + L
Sbjct: 118 PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLT 177
Query: 276 LSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPES 335
++ N+L +LP A+ LS L++L L+ N L D LP IG L +L E A+N L+ +P S
Sbjct: 178 VTHNRLQTLPPALGALSTLQRLDLSQNLL--DTLPPEIGGLGSLLELNLASNRLQSLPAS 235
Query: 336 LCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD 384
L LR LVL+ N L ++P + L + LD+R+N +PP+ D
Sbjct: 236 LAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLD 284
Score = 82.8 bits (203), Expect = 2e-15
Identities = 98/332 (29%), Positives = 147/332 (44%), Gaps = 33/332 (9%)
Query: 10 VRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPE------ELAALQKLEHLSV 63
V G +L G ++ +L +L NR L P L Q L+ L V
Sbjct: 5 VEGPELEAAAAAGDASEDSDAGSRALPFLGGNRLSLDLYPGGCQQLLHLCVQQPLQLLQV 64
Query: 64 SHNNLTT------LHGELSSLPS----LRAIVARANSLKNS----------GVPDDIFKL 103
L+T L L+ LP LR++V + +++ +P + L
Sbjct: 65 EFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGL 124
Query: 104 DDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRL 163
L+ LDLS N L P + + + L LSHN + +P L L L +L ++ NRL
Sbjct: 125 AHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGA-LPALTFLTVTHNRL 183
Query: 164 ESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLS 223
++LPP + L LQ L L+ N LL ++ + +L L+L S R QS LP SL GL
Sbjct: 184 QTLPPALGALSTLQRLDLSQN-LLDTLPPEIGGLGSLLELNLAS-NRLQS-LPASLAGLR 240
Query: 224 NLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITEL--SLCIDQWVHVETLNLSRNQL 281
+L + L N L VP L LP L RL+L NQ+ +L L +V ++ L
Sbjct: 241 SLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQGNPLGEASP 300
Query: 282 TSLPSAICKL-SKLKKLYLNSNKLDFDGLPSG 312
+ S + L ++ +L+L S+ F P G
Sbjct: 301 DAPSSPVAALIPEMPRLFLTSDLDSFPVTPQG 332
Score = 61.2 bits (147), Expect = 6e-09
Identities = 44/125 (35%), Positives = 70/125 (56%), Gaps = 4/125 (3%)
Query: 2 EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHL 61
EA G LP + + ++ N + P + A+++L+ L L++ L LP E+ L L L
Sbjct: 165 EALGALPALTFLTVTHNRLQT--LPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLEL 222
Query: 62 SVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPR 121
+++ N L +L L+ L SLR +V +N L + VP D+ +L L+ LDL NQL + P
Sbjct: 223 NLASNRLQSLPASLAGLRSLRLLVLHSNLL--ASVPADLARLPLLTRLDLRDNQLRDLPP 280
Query: 122 ELENA 126
EL +A
Sbjct: 281 ELLDA 285
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,219,395
Number of Sequences: 37866
Number of extensions: 2293107
Number of successful extensions: 18982
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 298
Number of HSP's successfully gapped in prelim test: 192
Number of HSP's that attempted gapping in prelim test: 12363
Number of HSP's gapped (non-prelim): 3639
length of query: 1269
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1155
effective length of database: 13,930,794
effective search space: 16090067070
effective search space used: 16090067070
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.