Search of human proteins with 4503687

Search of human proteins with 4503687

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
         (822 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]          1642   0.0  
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]        1390   0.0  
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]        1349   0.0  
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]        1097   0.0  
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]     800   0.0  
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   260   3e-69
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   260   3e-69
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             254   3e-67
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               254   3e-67
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             254   3e-67
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             254   3e-67
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             254   3e-67
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                241   3e-63
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [...   241   3e-63
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [...   241   3e-63
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [...   241   3e-63
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   236   5e-62
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]            236   6e-62
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]           236   6e-62
gi|4503787 fyn-related kinase [Homo sapiens]                          234   2e-61
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       234   2e-61
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   234   3e-61
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               233   7e-61
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       232   9e-61
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              230   4e-60
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   228   1e-59
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   228   1e-59
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      228   2e-59
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     224   3e-58
gi|4758078 c-src tyrosine kinase [Homo sapiens]                       224   3e-58

>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
          Length = 822

 Score = 1642 bits (4251), Expect = 0.0
 Identities = 822/822 (100%), Positives = 822/822 (100%)

Query: 1   MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
           MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS
Sbjct: 1   MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60

Query: 61  RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
           RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW
Sbjct: 61  RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120

Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
           QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF
Sbjct: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180

Query: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
           AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE
Sbjct: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240

Query: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
           VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE
Sbjct: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300

Query: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
           LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL
Sbjct: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360

Query: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420
           QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR
Sbjct: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420

Query: 421 TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF 480
           TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF
Sbjct: 421 TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF 480

Query: 481 LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 540
           LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK
Sbjct: 481 LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 540

Query: 541 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 600
           SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL
Sbjct: 541 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 600

Query: 601 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 660
           KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL
Sbjct: 601 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 660

Query: 661 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 720
           LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR
Sbjct: 661 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 720

Query: 721 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 780
           QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP
Sbjct: 721 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 780

Query: 781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
           CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822


>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
          Length = 764

 Score = 1390 bits (3597), Expect = 0.0
 Identities = 693/696 (99%), Positives = 696/696 (100%)

Query: 127 LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 186
           +++THSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY
Sbjct: 69  ISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 128

Query: 187 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 246
           VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR
Sbjct: 129 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 188

Query: 247 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 306
           EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV
Sbjct: 189 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 248

Query: 307 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 366
           QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG
Sbjct: 249 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 308

Query: 367 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 426
           LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI
Sbjct: 309 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 368

Query: 427 LKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ 486
           LKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ
Sbjct: 369 LKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ 428

Query: 487 GKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 546
           GKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH
Sbjct: 429 GKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 488

Query: 547 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 606
           RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ
Sbjct: 489 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 548

Query: 607 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 666
           EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD
Sbjct: 549 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 608

Query: 667 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 726
           AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW
Sbjct: 609 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 668

Query: 727 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 786
           TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP
Sbjct: 669 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 728

Query: 787 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
           DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 729 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 764


>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
          Length = 752

 Score = 1349 bits (3491), Expect = 0.0
 Identities = 706/822 (85%), Positives = 716/822 (87%), Gaps = 70/822 (8%)

Query: 1   MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
           MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS
Sbjct: 1   MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60

Query: 61  RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
           RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW
Sbjct: 61  RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120

Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
           QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF
Sbjct: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180

Query: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
           AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE
Sbjct: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240

Query: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
           VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE
Sbjct: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300

Query: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
           LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL
Sbjct: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360

Query: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420
           QEALQGLQVALCSQAK       LQ + E           LLQ         E       
Sbjct: 361 QEALQGLQVALCSQAK-------LQAQQE-----------LLQTKLEHLGPGE------- 395

Query: 421 TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF 480
                                PPP+ L+ + +                       HS   
Sbjct: 396 ---------------------PPPVLLLQDDR-----------------------HSTSS 411

Query: 481 LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 540
             +E +G +   L +L   +   F      NLYRLEGEGFPSIPLLIDHLLSTQQPLTKK
Sbjct: 412 SEQEREGGRTPTLEILKSHISGIFR-PKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 470

Query: 541 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 600
           SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL
Sbjct: 471 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 530

Query: 601 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 660
           KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL
Sbjct: 531 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 590

Query: 661 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 720
           LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR
Sbjct: 591 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 650

Query: 721 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 780
           QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP
Sbjct: 651 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 710

Query: 781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
           CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 711 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752


>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
          Length = 694

 Score = 1097 bits (2837), Expect = 0.0
 Identities = 577/696 (82%), Positives = 590/696 (84%), Gaps = 70/696 (10%)

Query: 127 LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 186
           +++THSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY
Sbjct: 69  ISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 128

Query: 187 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 246
           VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR
Sbjct: 129 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 188

Query: 247 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 306
           EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV
Sbjct: 189 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 248

Query: 307 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 366
           QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG
Sbjct: 249 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 308

Query: 367 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 426
           LQVALCSQAK       LQ + E           LLQ         E             
Sbjct: 309 LQVALCSQAK-------LQAQQE-----------LLQTKLEHLGPGE------------- 337

Query: 427 LKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ 486
                          PPP+ L+ + +                       HS     +E +
Sbjct: 338 ---------------PPPVLLLQDDR-----------------------HSTSSSEQERE 359

Query: 487 GKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 546
           G +   L +L   +   F      NLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH
Sbjct: 360 GGRTPTLEILKSHISGIFR-PKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 418

Query: 547 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 606
           RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ
Sbjct: 419 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 478

Query: 607 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 666
           EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD
Sbjct: 479 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 538

Query: 667 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 726
           AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW
Sbjct: 539 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 598

Query: 727 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 786
           TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP
Sbjct: 599 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 658

Query: 787 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
           DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 659 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 694


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score =  800 bits (2066), Expect = 0.0
 Identities = 420/827 (50%), Positives = 574/827 (69%), Gaps = 14/827 (1%)

Query: 1   MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
           MGF S+L     H  + ++Q+ ELRLLE ++K+MA R+KSD+EYA  L ++  Q     +
Sbjct: 1   MGFGSDL--KNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKEST 58

Query: 61  RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
             ++  S +S+SW  +  QTE LSR+++ HAEDLNSGPL +L+++I+++QQ++K+Y    
Sbjct: 59  VQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVH 118

Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEA-SKDKDRDKAKDKYVRSLWKL 179
           QQ++ E+ K    ++EKLK  YR L ++   AK KY+EA +K K+ +KAK++Y ++  KL
Sbjct: 119 QQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKL 178

Query: 180 FAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQD 239
              HN+YVL ++ AQLH   ++ + LP LL SLQ + EEM   LK I  EY +I+SLV +
Sbjct: 179 HMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTE 238

Query: 240 EVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLN 299
           E+V +H+E+  +  +I P  EY  F+  + +       + FD SLLEE E L+  E+  N
Sbjct: 239 EIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWN 298

Query: 300 ELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPR-ERVQLLGKRQ 358
            LT ES+Q  L ++ +EL    +M+  ++E V +L++ +    E    + + V LL ++Q
Sbjct: 299 NLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQ 358

Query: 359 VLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREG 418
            L+E  Q +Q   C++AK  AQ+ELL+ K++     EPPPV+  ++D  S +S E++   
Sbjct: 359 ALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKE-- 416

Query: 419 GRTPTLEILKSHISGIFR-PKFSLPPPL--QLIPEVQKPLHEQLWYHGAIPRAEVAELLV 475
            R    E ++  I+GI R PK +L       +I   +KPL EQ WYHGAIPR E  ELL 
Sbjct: 417 -RLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLK 475

Query: 476 HSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQ 534
             GDFLVRES GK  EYVLSV  DG  RHFIIQ +DN+YR EG GF +IP LIDH  +T+
Sbjct: 476 KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTK 535

Query: 535 QPLTKKSGVVLHRAVPKDK-WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR 593
           Q +TKKSGVVL   +PKDK W+L+HED++LGE +G+GNFGEV+ G L+ D T VAVK+C+
Sbjct: 536 QVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLK-DKTSVAVKTCK 594

Query: 594 ETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGA 653
           E LP +LK KFLQEA+ILKQY HPNIV+LIGVCTQ+QP+YI+MELV GGDFLTFLR +  
Sbjct: 595 EDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKD 654

Query: 654 RLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVY 713
            L++K L++   DAAAGM YLESK CIHRDLAARNCLV E NVLKISDFGMSR+E  GVY
Sbjct: 655 ELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVY 714

Query: 714 AASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV 773
           ++S GL+Q+P+KWTAPEALNYGRYSSESDVWSFGILLWETFSLG  PYP ++NQQ RE V
Sbjct: 715 SSS-GLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV 773

Query: 774 EKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 820
           E+G R+  P+ CP+ + ++M +CW Y+P  RP FS + +EL  I+++
Sbjct: 774 ERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRK 820


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  260 bits (665), Expect = 3e-69
 Identities = 144/380 (37%), Positives = 221/380 (58%), Gaps = 22/380 (5%)

Query: 455 LHEQLWYHGAIPRAEVAELLVHSG---DFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLD 510
           L +  WYHG + R   AE L+ SG    FLVRES+    +  +S+ ++G   H+ I +  
Sbjct: 122 LEKHSWYHGPVSR-NAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180

Query: 511 N--LYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKSGVVLHRAVPK-DKWVLNHE 559
           +  LY      F ++  L+ H        + +   P  K++   ++   P  DKW +   
Sbjct: 181 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT 240

Query: 560 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPN 618
           D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA ++K+  HPN
Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPN 297

Query: 619 IVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESK 677
           +V+L+GVCT++ P YI+ E +  G+ L +LR      +    LL M    ++ MEYLE K
Sbjct: 298 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 357

Query: 678 CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRY 737
             IHRDLAARNCLV E +++K++DFG+SR      Y A  G +  P+KWTAPE+L Y ++
Sbjct: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKF 416

Query: 738 SSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCW 797
           S +SDVW+FG+LLWE  + G SPYP +   Q  E +EK  R+  PE CP+ V+ LM  CW
Sbjct: 417 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW 476

Query: 798 AYEPGQRPSFSTIYQELQSI 817
            + P  RPSF+ I+Q  +++
Sbjct: 477 QWNPSDRPSFAEIHQAFETM 496


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  260 bits (665), Expect = 3e-69
 Identities = 144/380 (37%), Positives = 221/380 (58%), Gaps = 22/380 (5%)

Query: 455 LHEQLWYHGAIPRAEVAELLVHSG---DFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLD 510
           L +  WYHG + R   AE L+ SG    FLVRES+    +  +S+ ++G   H+ I +  
Sbjct: 141 LEKHSWYHGPVSR-NAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 199

Query: 511 N--LYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKSGVVLHRAVPK-DKWVLNHE 559
           +  LY      F ++  L+ H        + +   P  K++   ++   P  DKW +   
Sbjct: 200 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT 259

Query: 560 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPN 618
           D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA ++K+  HPN
Sbjct: 260 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPN 316

Query: 619 IVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESK 677
           +V+L+GVCT++ P YI+ E +  G+ L +LR      +    LL M    ++ MEYLE K
Sbjct: 317 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 376

Query: 678 CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRY 737
             IHRDLAARNCLV E +++K++DFG+SR      Y A  G +  P+KWTAPE+L Y ++
Sbjct: 377 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKF 435

Query: 738 SSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCW 797
           S +SDVW+FG+LLWE  + G SPYP +   Q  E +EK  R+  PE CP+ V+ LM  CW
Sbjct: 436 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW 495

Query: 798 AYEPGQRPSFSTIYQELQSI 817
            + P  RPSF+ I+Q  +++
Sbjct: 496 QWNPSDRPSFAEIHQAFETM 515


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  254 bits (648), Expect = 3e-67
 Identities = 144/383 (37%), Positives = 215/383 (56%), Gaps = 28/383 (7%)

Query: 455 LHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDN 511
           L +  WYHG + R+    LL  + +G FLVRES+    +  +S+ ++G   H+ I +  +
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212

Query: 512 --LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPK-------------DKWVL 556
             +Y      F ++  L+ H  +    L       LH   PK             DKW +
Sbjct: 213 GKVYVTAESRFSTLAELVHHHSTVADGLV----TTLHYPAPKCNKPTVYGVSPIHDKWEM 268

Query: 557 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYS 615
              D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA ++K+  
Sbjct: 269 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK 325

Query: 616 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYL 674
           HPN+V+L+GVCT + P YIV E +  G+ L +LR      +    LL M    ++ MEYL
Sbjct: 326 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 385

Query: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 734
           E K  IHRDLAARNCLV E +V+K++DFG+SR      Y A  G +  P+KWTAPE+L Y
Sbjct: 386 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAY 444

Query: 735 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 794
             +S +SDVW+FG+LLWE  + G SPYP +   Q  + +EKG R+  PE CP  V+ LM 
Sbjct: 445 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 504

Query: 795 QCWAYEPGQRPSFSTIYQELQSI 817
            CW + P  RPSF+  +Q  +++
Sbjct: 505 ACWKWSPADRPSFAETHQAFETM 527


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  254 bits (648), Expect = 3e-67
 Identities = 144/383 (37%), Positives = 215/383 (56%), Gaps = 28/383 (7%)

Query: 455 LHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDN 511
           L +  WYHG + R+    LL  + +G FLVRES+    +  +S+ ++G   H+ I +  +
Sbjct: 168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 227

Query: 512 --LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPK-------------DKWVL 556
             +Y      F ++  L+ H  +    L       LH   PK             DKW +
Sbjct: 228 GKVYVTAESRFSTLAELVHHHSTVADGLV----TTLHYPAPKCNKPTVYGVSPIHDKWEM 283

Query: 557 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYS 615
              D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA ++K+  
Sbjct: 284 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK 340

Query: 616 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYL 674
           HPN+V+L+GVCT + P YIV E +  G+ L +LR      +    LL M    ++ MEYL
Sbjct: 341 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 400

Query: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 734
           E K  IHRDLAARNCLV E +V+K++DFG+SR      Y A  G +  P+KWTAPE+L Y
Sbjct: 401 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAY 459

Query: 735 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 794
             +S +SDVW+FG+LLWE  + G SPYP +   Q  + +EKG R+  PE CP  V+ LM 
Sbjct: 460 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 519

Query: 795 QCWAYEPGQRPSFSTIYQELQSI 817
            CW + P  RPSF+  +Q  +++
Sbjct: 520 ACWKWSPADRPSFAETHQAFETM 542


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  254 bits (648), Expect = 3e-67
 Identities = 144/383 (37%), Positives = 215/383 (56%), Gaps = 28/383 (7%)

Query: 455 LHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDN 511
           L +  WYHG + R+    LL  + +G FLVRES+    +  +S+ ++G   H+ I +  +
Sbjct: 147 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 206

Query: 512 --LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPK-------------DKWVL 556
             +Y      F ++  L+ H  +    L       LH   PK             DKW +
Sbjct: 207 GKVYVTAESRFSTLAELVHHHSTVADGLV----TTLHYPAPKCNKPTVYGVSPIHDKWEM 262

Query: 557 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYS 615
              D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA ++K+  
Sbjct: 263 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK 319

Query: 616 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYL 674
           HPN+V+L+GVCT + P YIV E +  G+ L +LR      +    LL M    ++ MEYL
Sbjct: 320 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 379

Query: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 734
           E K  IHRDLAARNCLV E +V+K++DFG+SR      Y A  G +  P+KWTAPE+L Y
Sbjct: 380 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAY 438

Query: 735 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 794
             +S +SDVW+FG+LLWE  + G SPYP +   Q  + +EKG R+  PE CP  V+ LM 
Sbjct: 439 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 498

Query: 795 QCWAYEPGQRPSFSTIYQELQSI 817
            CW + P  RPSF+  +Q  +++
Sbjct: 499 ACWKWSPADRPSFAETHQAFETM 521


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  254 bits (648), Expect = 3e-67
 Identities = 144/383 (37%), Positives = 215/383 (56%), Gaps = 28/383 (7%)

Query: 455 LHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDN 511
           L +  WYHG + R+    LL  + +G FLVRES+    +  +S+ ++G   H+ I +  +
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212

Query: 512 --LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPK-------------DKWVL 556
             +Y      F ++  L+ H  +    L       LH   PK             DKW +
Sbjct: 213 GKVYVTAESRFSTLAELVHHHSTVADGLV----TTLHYPAPKCNKPTVYGVSPIHDKWEM 268

Query: 557 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYS 615
              D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA ++K+  
Sbjct: 269 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK 325

Query: 616 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYL 674
           HPN+V+L+GVCT + P YIV E +  G+ L +LR      +    LL M    ++ MEYL
Sbjct: 326 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 385

Query: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 734
           E K  IHRDLAARNCLV E +V+K++DFG+SR      Y A  G +  P+KWTAPE+L Y
Sbjct: 386 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAY 444

Query: 735 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 794
             +S +SDVW+FG+LLWE  + G SPYP +   Q  + +EKG R+  PE CP  V+ LM 
Sbjct: 445 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 504

Query: 795 QCWAYEPGQRPSFSTIYQELQSI 817
            CW + P  RPSF+  +Q  +++
Sbjct: 505 ACWKWSPADRPSFAETHQAFETM 527


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  254 bits (648), Expect = 3e-67
 Identities = 144/383 (37%), Positives = 215/383 (56%), Gaps = 28/383 (7%)

Query: 455 LHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDN 511
           L +  WYHG + R+    LL  + +G FLVRES+    +  +S+ ++G   H+ I +  +
Sbjct: 132 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 191

Query: 512 --LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPK-------------DKWVL 556
             +Y      F ++  L+ H  +    L       LH   PK             DKW +
Sbjct: 192 GKVYVTAESRFSTLAELVHHHSTVADGLV----TTLHYPAPKCNKPTVYGVSPIHDKWEM 247

Query: 557 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYS 615
              D+ +  ++G G +GEV+ G  +  +  VAVK+ +E T+  +   +FL+EA ++K+  
Sbjct: 248 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK 304

Query: 616 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYL 674
           HPN+V+L+GVCT + P YIV E +  G+ L +LR      +    LL M    ++ MEYL
Sbjct: 305 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 364

Query: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 734
           E K  IHRDLAARNCLV E +V+K++DFG+SR      Y A  G +  P+KWTAPE+L Y
Sbjct: 365 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAY 423

Query: 735 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 794
             +S +SDVW+FG+LLWE  + G SPYP +   Q  + +EKG R+  PE CP  V+ LM 
Sbjct: 424 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 483

Query: 795 QCWAYEPGQRPSFSTIYQELQSI 817
            CW + P  RPSF+  +Q  +++
Sbjct: 484 ACWKWSPADRPSFAETHQAFETM 506


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  241 bits (614), Expect = 3e-63
 Identities = 147/399 (36%), Positives = 216/399 (54%), Gaps = 29/399 (7%)

Query: 443 PPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGD---FLVRESQGKQEYVLSVLWDG 499
           P   L+ +    L    WY+ +I R +  +LL+ +G    F+VR+S+    Y +SV    
Sbjct: 222 PSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKA 281

Query: 500 LP-------RHFIIQSLDN----LYRLEGEGFPSIPLLIDH--------LLSTQQPLT-K 539
           +        +H+ I+  ++     Y  E   F SIPLLI++        +   + P+   
Sbjct: 282 VVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFG 341

Query: 540 KSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGR-LRADNTLVAVKSCRETLPP 598
           +    +   +   KWV++  +L   ++IG G FG V  G  L  D   VA+K+ RE    
Sbjct: 342 RQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDK--VAIKTIREGAMS 399

Query: 599 DLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVK 658
           +    F++EA ++ + SHP +V+L GVC ++ PI +V E ++ G    +LRT+      +
Sbjct: 400 E--EDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAE 457

Query: 659 TLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGG 718
           TLL M  D   GM YLE  C IHRDLAARNCLV E  V+K+SDFGM+R   D  Y +S G
Sbjct: 458 TLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTG 517

Query: 719 LRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGR 778
            +  PVKW +PE  ++ RYSS+SDVWSFG+L+WE FS G  PY N SN +  E +  G R
Sbjct: 518 TK-FPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFR 576

Query: 779 LPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 817
           L  P L    V+++M  CW   P  RP+FS + ++L  I
Sbjct: 577 LYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEI 615


>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
           [Homo sapiens]
          Length = 466

 Score =  241 bits (614), Expect = 3e-63
 Identities = 153/392 (39%), Positives = 208/392 (53%), Gaps = 34/392 (8%)

Query: 436 RPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLV--HSGDFLVRES-QGKQEYV 492
           R   S  P L L+P          W+HG I   E  + L     G FLVRES +   +YV
Sbjct: 67  REALSADPKLSLMP----------WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYV 116

Query: 493 LSVLWDGLPRHFIIQSLDNLYRL-EGEGFPSIPLLIDHLLSTQ--------QPLTKKSGV 543
           L V +     H+ +   D    + E   F ++  +++H    +        +P  K    
Sbjct: 117 LCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTK 176

Query: 544 VLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK 603
                + +  W+LN + L LG QIG G FG V  G        V    C  T        
Sbjct: 177 SAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA----- 231

Query: 604 FLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQ 662
           FL E  ++ +  H N+VRL+GV    Q +YIVME V  G+ + FLRT G A +    LLQ
Sbjct: 232 FLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQ 290

Query: 663 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQV 722
                A GMEYLESK  +HRDLAARN LV+E  V K+SDFG+++ E  G+ ++     ++
Sbjct: 291 FSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RL 345

Query: 723 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCP 782
           PVKWTAPEAL +G+++S+SDVWSFG+LLWE FS G +PYP +S ++  E VEKG R+  P
Sbjct: 346 PVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP 405

Query: 783 ELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 814
           E CP  V  LM  CW  EP +RP F  + ++L
Sbjct: 406 EGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 437


>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
           [Homo sapiens]
          Length = 508

 Score =  241 bits (614), Expect = 3e-63
 Identities = 153/392 (39%), Positives = 208/392 (53%), Gaps = 34/392 (8%)

Query: 436 RPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLV--HSGDFLVRES-QGKQEYV 492
           R   S  P L L+P          W+HG I   E  + L     G FLVRES +   +YV
Sbjct: 109 REALSADPKLSLMP----------WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYV 158

Query: 493 LSVLWDGLPRHFIIQSLDNLYRL-EGEGFPSIPLLIDHLLSTQ--------QPLTKKSGV 543
           L V +     H+ +   D    + E   F ++  +++H    +        +P  K    
Sbjct: 159 LCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTK 218

Query: 544 VLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK 603
                + +  W+LN + L LG QIG G FG V  G        V    C  T        
Sbjct: 219 SAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA----- 273

Query: 604 FLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQ 662
           FL E  ++ +  H N+VRL+GV    Q +YIVME V  G+ + FLRT G A +    LLQ
Sbjct: 274 FLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQ 332

Query: 663 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQV 722
                A GMEYLESK  +HRDLAARN LV+E  V K+SDFG+++ E  G+ ++     ++
Sbjct: 333 FSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RL 387

Query: 723 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCP 782
           PVKWTAPEAL +G+++S+SDVWSFG+LLWE FS G +PYP +S ++  E VEKG R+  P
Sbjct: 388 PVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP 447

Query: 783 ELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 814
           E CP  V  LM  CW  EP +RP F  + ++L
Sbjct: 448 EGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 479


>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
           [Homo sapiens]
          Length = 507

 Score =  241 bits (614), Expect = 3e-63
 Identities = 153/392 (39%), Positives = 208/392 (53%), Gaps = 34/392 (8%)

Query: 436 RPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLV--HSGDFLVRES-QGKQEYV 492
           R   S  P L L+P          W+HG I   E  + L     G FLVRES +   +YV
Sbjct: 108 REALSADPKLSLMP----------WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYV 157

Query: 493 LSVLWDGLPRHFIIQSLDNLYRL-EGEGFPSIPLLIDHLLSTQ--------QPLTKKSGV 543
           L V +     H+ +   D    + E   F ++  +++H    +        +P  K    
Sbjct: 158 LCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTK 217

Query: 544 VLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK 603
                + +  W+LN + L LG QIG G FG V  G        V    C  T        
Sbjct: 218 SAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA----- 272

Query: 604 FLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQ 662
           FL E  ++ +  H N+VRL+GV    Q +YIVME V  G+ + FLRT G A +    LLQ
Sbjct: 273 FLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQ 331

Query: 663 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQV 722
                A GMEYLESK  +HRDLAARN LV+E  V K+SDFG+++ E  G+ ++     ++
Sbjct: 332 FSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RL 386

Query: 723 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCP 782
           PVKWTAPEAL +G+++S+SDVWSFG+LLWE FS G +PYP +S ++  E VEKG R+  P
Sbjct: 387 PVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP 446

Query: 783 ELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 814
           E CP  V  LM  CW  EP +RP F  + ++L
Sbjct: 447 EGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 478


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  236 bits (603), Expect = 5e-62
 Identities = 157/444 (35%), Positives = 230/444 (51%), Gaps = 27/444 (6%)

Query: 396 PPPVLLLQDDRHSTSSSEQEREGGRTPTLE-----ILKSHISGIFRPKFSLPPPLQLIPE 450
           P   L L D           R G R   LE     I    +SG  +P   L P   +   
Sbjct: 53  PQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSG--QPSAGLVPITHVAKA 110

Query: 451 VQKPLHEQLWYHGAIPRAEVAELLV----HSGDFLVRESQGKQE-YVLSVLWDGLPRHFI 505
             + L +Q WY   + R +  +LL+      G FL+R S+     Y LSV       H+ 
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170

Query: 506 IQSL--DNLYRLEGEGFPSIPLLIDHLLST----QQPLTKKSGVVLHRAVPKDKWVLNHE 559
           +      +LY  +G  FP +  L+ +  +     Q PL +    +  +A  +D W   H 
Sbjct: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPC--MPQKAPRQDVWERPHS 228

Query: 560 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFL-QEARILKQYSHPN 618
           +  LG ++G G FGEV+ G L   +  VA+K  +     ++K   L +E + LK   H  
Sbjct: 229 EFALGRKLGEGYFGEVWEG-LWLGSLPVAIKVIKSA---NMKLTDLAKEIQTLKGLRHER 284

Query: 619 IVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESK 677
           ++RL  VC+  +P+YIV EL++ G+   FL T EG  LR+  LL      A GM YLE +
Sbjct: 285 LIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQ 344

Query: 678 CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRY 737
             +HRDLAARN LV +    K++DFG++R   D +Y+ S   + +PVKWTAPEA NY  +
Sbjct: 345 RVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSK-IPVKWTAPEAANYRVF 403

Query: 738 SSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCW 797
           S +SDVWSFG+LL E F+ G  PY  ++N +T + + +G RLP P  CP  V+ LM +CW
Sbjct: 404 SQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECW 463

Query: 798 AYEPGQRPSFSTIYQELQSIRKRH 821
              P +RPSF+T+ ++L +I + H
Sbjct: 464 RSSPEERPSFATLREKLHAIHRCH 487


>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  236 bits (602), Expect = 6e-62
 Identities = 147/406 (36%), Positives = 219/406 (53%), Gaps = 26/406 (6%)

Query: 438 KFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGD---FLVRESQGKQEYVLS 494
           K S   P     E ++ L +  W+ G I R++  +LL   G    F+VR S     Y +S
Sbjct: 274 KISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVS 333

Query: 495 VLWD------GLPRHFIIQSL--DNLYRLEGEGFPSIPLLIDH--------LLSTQQPLT 538
           +         G  +H+ + +   + LY  E   F SIP LI +        +   + P++
Sbjct: 334 LFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVS 393

Query: 539 KKSGVVLHR-AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TL 596
            K+  V    ++    W L  E++ L +++G G FG V  G+ +     VAVK  +E ++
Sbjct: 394 TKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYD-VAVKMIKEGSM 452

Query: 597 PPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLR 656
             D   +F QEA+ + + SHP +V+  GVC+++ PIYIV E +  G  L +LR+ G  L 
Sbjct: 453 SED---EFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLE 509

Query: 657 VKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAAS 716
              LL+M  D   GM +LES   IHRDLAARNCLV     +K+SDFGM+R   D  Y +S
Sbjct: 510 PSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS 569

Query: 717 GGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG 776
            G +  PVKW+APE  +Y +YSS+SDVW+FGIL+WE FSLG  PY    N Q    V +G
Sbjct: 570 VGTK-FPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQG 628

Query: 777 GRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
            RL  P L  D ++++M  CW   P +RP+F  +   ++ +R++ +
Sbjct: 629 HRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDK 674


>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  236 bits (602), Expect = 6e-62
 Identities = 147/406 (36%), Positives = 219/406 (53%), Gaps = 26/406 (6%)

Query: 438 KFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGD---FLVRESQGKQEYVLS 494
           K S   P     E ++ L +  W+ G I R++  +LL   G    F+VR S     Y +S
Sbjct: 274 KISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVS 333

Query: 495 VLWD------GLPRHFIIQSL--DNLYRLEGEGFPSIPLLIDH--------LLSTQQPLT 538
           +         G  +H+ + +   + LY  E   F SIP LI +        +   + P++
Sbjct: 334 LFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVS 393

Query: 539 KKSGVVLHR-AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TL 596
            K+  V    ++    W L  E++ L +++G G FG V  G+ +     VAVK  +E ++
Sbjct: 394 TKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYD-VAVKMIKEGSM 452

Query: 597 PPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLR 656
             D   +F QEA+ + + SHP +V+  GVC+++ PIYIV E +  G  L +LR+ G  L 
Sbjct: 453 SED---EFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLE 509

Query: 657 VKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAAS 716
              LL+M  D   GM +LES   IHRDLAARNCLV     +K+SDFGM+R   D  Y +S
Sbjct: 510 PSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS 569

Query: 717 GGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG 776
            G +  PVKW+APE  +Y +YSS+SDVW+FGIL+WE FSLG  PY    N Q    V +G
Sbjct: 570 VGTK-FPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQG 628

Query: 777 GRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
            RL  P L  D ++++M  CW   P +RP+F  +   ++ +R++ +
Sbjct: 629 HRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDK 674


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  234 bits (598), Expect = 2e-61
 Identities = 139/385 (36%), Positives = 223/385 (57%), Gaps = 27/385 (7%)

Query: 453 KPLHEQLWYHGAIPRAEVAELLVHS----GDFLVRESQG-KQEYVLSVLWDGLPRHFIIQ 507
           + L  + W+ GAI R++  + L++S    G FL+RES+  K E+ LSVL   + +H+ I+
Sbjct: 109 RSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIK 168

Query: 508 SLDN--LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGV-VLHRAVPK---------DKWV 555
            LD    +      F ++   + H   T   L  K G   L   VP          D+W 
Sbjct: 169 RLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWE 228

Query: 556 LNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQY 614
           ++   + L +++G G FGEV+ G L  + T VAVK+ +  ++ P+    FL+EA+I+K  
Sbjct: 229 IDRNSIQLLKRLGSGQFGEVWEG-LWNNTTPVAVKTLKPGSMDPN---DFLREAQIMKNL 284

Query: 615 SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE-GARLRVKTLLQMVGDAAAGMEY 673
            HP +++L  VCT + PIYI+ EL++ G    +L+ + G+++ +   + M    A+GM Y
Sbjct: 285 RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAY 344

Query: 674 LESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE---EADGVYAASGGLRQVPVKWTAPE 730
           LES+  IHRDLAARN LV E N+ K++DFG++R    + + +Y +   ++ +PVKWTAPE
Sbjct: 345 LESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK-LPVKWTAPE 403

Query: 731 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF 790
           A+   ++S +SDVWSFGILL+E  + G  PY  ++  Q  + + +  RLP P  CP   +
Sbjct: 404 AIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFY 463

Query: 791 RLMEQCWAYEPGQRPSFSTIYQELQ 815
            +M +CW  EP +RP+F T+  +L+
Sbjct: 464 NIMLECWNAEPKERPTFETLRWKLE 488


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  234 bits (597), Expect = 2e-61
 Identities = 145/379 (38%), Positives = 212/379 (55%), Gaps = 29/379 (7%)

Query: 460 WYHGAIPRAEVAELLVHSGD----FLVRESQG-KQEYVLSVL-WDGLP----RHFIIQSL 509
           WY G + R +    L+  G+    FL+RES+  K  Y LS+  WD +     +H+ I+ L
Sbjct: 149 WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKL 208

Query: 510 DN--LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP---------KDKWVLNH 558
           DN   Y      F ++  L+ H       L  +  V  H+ +P         KD W +  
Sbjct: 209 DNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPR 268

Query: 559 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHP 617
           E L L +++G G FGEV+ G     NT VA+K+ +  T+ P+    FL+EA+I+K+  H 
Sbjct: 269 ESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPE---SFLEEAQIMKKLKHD 324

Query: 618 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLES 676
            +V+L  V ++ +PIYIV E +  G  L FL+  EG  L++  L+ M    AAGM Y+E 
Sbjct: 325 KLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 383

Query: 677 KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR 736
              IHRDL + N LV    + KI+DFG++R   D  Y A  G +  P+KWTAPEA  YGR
Sbjct: 384 MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGR 442

Query: 737 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 796
           ++ +SDVWSFGILL E  + G  PYP ++N++  E VE+G R+PCP+ CP ++  LM  C
Sbjct: 443 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 502

Query: 797 WAYEPGQRPSFSTIYQELQ 815
           W  +P +RP+F  +   L+
Sbjct: 503 WKKDPEERPTFEYLQSFLE 521


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  234 bits (596), Expect = 3e-61
 Identities = 134/395 (33%), Positives = 220/395 (55%), Gaps = 26/395 (6%)

Query: 444 PLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGD---FLVRESQGKQEYVLSVLW--- 497
           P   + E +  +    WY   + R++  +LL   G    F+VR+S    +Y +SV     
Sbjct: 265 PSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKST 324

Query: 498 ---DGLPRHFIIQSL--DNLYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKSGVV 544
               G+ RH+++ S      Y  E   F +IP LI++        +   + P+++++   
Sbjct: 325 GDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNA 384

Query: 545 LHRA-VPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKA 602
              A +    W ++ +DL   +++G G FG V  G+ R     VA+K  +E ++  D   
Sbjct: 385 PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSED--- 440

Query: 603 KFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQ 662
           +F++EA+++   SH  +V+L GVCT+++PI+I+ E +  G  L +LR    R + + LL+
Sbjct: 441 EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLE 500

Query: 663 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQV 722
           M  D    MEYLESK  +HRDLAARNCLV ++ V+K+SDFG+SR   D  Y +S G  + 
Sbjct: 501 MCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVG-SKF 559

Query: 723 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCP 782
           PV+W+ PE L Y ++SS+SD+W+FG+L+WE +SLG  PY   +N +T E + +G RL  P
Sbjct: 560 PVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRP 619

Query: 783 ELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 817
            L  + V+ +M  CW  +  +RP+F  +   +  +
Sbjct: 620 HLASEKVYTIMYSCWHEKADERPTFKILLSNILDV 654


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  233 bits (593), Expect = 7e-61
 Identities = 142/385 (36%), Positives = 208/385 (54%), Gaps = 26/385 (6%)

Query: 455 LHEQLWYHGAIPRAEVAELLVHS---GDFLVRESQGKQEYVLSVLW----DGLP--RHFI 505
           L +  WY   + R++  +LL      G F+VR+S     Y +S+      +G    RH+ 
Sbjct: 242 LDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYH 301

Query: 506 IQ----SLDNLYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKS-GVVLHRAVPKD 552
           I+    S    Y  E   F SIP +I++        +   + P++ K            +
Sbjct: 302 IKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYE 361

Query: 553 KWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILK 612
           KW +N  +L    ++G G FG V  G+ RA    VA+K+ RE      +  F++EA+++ 
Sbjct: 362 KWEINPSELTFMRELGSGLFGVVRLGKWRAQYK-VAIKAIREGAM--CEEDFIEEAKVMM 418

Query: 613 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 672
           + +HP +V+L GVCTQ++PIYIV E ++ G  L FLR          LL M  D   GME
Sbjct: 419 KLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGME 478

Query: 673 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL 732
           YLE    IHRDLAARNCLV+E  V+K+SDFGM+R   D  Y +S G +  PVKW  PE  
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAK-FPVKWCPPEVF 537

Query: 733 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 792
           NY R+SS+SDVWSFG+L+WE F+ G  P+   +N +    V +G RL  P+L  + V+ +
Sbjct: 538 NYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEV 597

Query: 793 MEQCWAYEPGQRPSFSTIYQELQSI 817
           M +CW  +P  RPSF  + + +  +
Sbjct: 598 MLRCWQEKPEGRPSFEDLLRTIDEL 622


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  232 bits (592), Expect = 9e-61
 Identities = 138/378 (36%), Positives = 208/378 (55%), Gaps = 24/378 (6%)

Query: 460 WYHGAIPRAEVAELLVHS---GDFLVRESQGKQEYVLSVLW------DGLPRHFIIQSLD 510
           WYH  I R +   LL      G F+VR+S+    Y +SV        +   +H+ I+  D
Sbjct: 150 WYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKND 209

Query: 511 N--LYRLEGEGFPSIPLLI---DHLLSTQQPLTKKSGVVLHRAVPK------DKWVLNHE 559
           +   Y  E   F SIP LI    H  +      +    ++   +P       +KW ++  
Sbjct: 210 SGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPS 269

Query: 560 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNI 619
           +L   ++IG G FG V  G  R+ +  VA+K+  E    +    F++EA+++ + SH  +
Sbjct: 270 ELAFIKEIGSGQFGVVHLGEWRS-HIQVAIKAINEGSMSE--EDFIEEAKVMMKLSHSKL 326

Query: 620 VRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCC 679
           V+L GVC Q++P+YIV E ++ G  L +LR    +LR + LL +  D   GMEYLE    
Sbjct: 327 VQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGY 386

Query: 680 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 739
           IHRDLAARNCLV+   ++KISDFGM+R   D  Y +S G +  P+KW+ PE   + +YSS
Sbjct: 387 IHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAK-FPIKWSPPEVFLFNKYSS 445

Query: 740 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 799
           +SDVWSFG+L+WE F+ G  P+ N SN Q  E + +G RL  P L P +++ +M  CW  
Sbjct: 446 KSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHE 505

Query: 800 EPGQRPSFSTIYQELQSI 817
           +P  RP+F+ + + +  I
Sbjct: 506 KPEGRPTFAELLRAVTEI 523


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  230 bits (587), Expect = 4e-60
 Identities = 148/376 (39%), Positives = 208/376 (55%), Gaps = 26/376 (6%)

Query: 460 WYHGAIPRAEVAELLVHSGD----FLVRESQG-KQEYVLSVL-WDGLP----RHFIIQSL 509
           WY G + R +   LL++ G+    FLVRES+  K  Y LS+  WD +     +H+ I+ L
Sbjct: 158 WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKL 217

Query: 510 DN--LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP------KDKWVLNHEDL 561
           DN   Y      F ++  L+ H       L  K   V     P      KD W +  E L
Sbjct: 218 DNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESL 277

Query: 562 VLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIV 620
            L  ++G+G FGEV+ G      T VA+K+ +  T+ P+    FLQEA+I+K+  H  +V
Sbjct: 278 RLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEA---FLQEAQIMKKLRHDKLV 333

Query: 621 RLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCC 679
            L  V ++ +PIYIV E +  G  L FL+  +G  L++  L+ M    A GM Y+E    
Sbjct: 334 PLYAVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNY 392

Query: 680 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 739
           IHRDL A N LV E  V KI+DFG++R   D  Y A  G +  P+KWTAPEA  YGR++ 
Sbjct: 393 IHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTI 451

Query: 740 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 799
           +SDVWSFGIL  E  + G  PYP + N++  E VE+G R+PCP+ CP+++  LM  CW  
Sbjct: 452 KSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKK 511

Query: 800 EPGQRPSFSTIYQELQ 815
           +P +RP+F  I   L+
Sbjct: 512 DPDERPTFEYIQSFLE 527


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  228 bits (582), Expect = 1e-59
 Identities = 150/380 (39%), Positives = 214/380 (56%), Gaps = 34/380 (8%)

Query: 460 WYHGAIPRAEVAELLVHS----GDFLVRESQG-KQEYVLSVL-WDGLP----RHFIIQSL 509
           WY G I R E   LL+++    G FLVRES+  K  Y LSV  +D       +H+ I+ L
Sbjct: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210

Query: 510 DN--LYRLEGEGFPSIPLLID----------HLLSTQQPLTKKSGVVLHRAVPKDKWVLN 557
           D+   Y      F S+  L+           H L+T  P +K       + + KD W + 
Sbjct: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQT----QGLAKDAWEIP 266

Query: 558 HEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSH 616
            E L L  ++G+G FGEV+ G      T VA+K+ +  T+ P+    FLQEA+++K+  H
Sbjct: 267 RESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEA---FLQEAQVMKKLRH 322

Query: 617 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE-GARLRVKTLLQMVGDAAAGMEYLE 675
             +V+L  V ++ +PIYIV E +  G  L FL+ E G  LR+  L+ M    A+GM Y+E
Sbjct: 323 EKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381

Query: 676 SKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYG 735
               +HRDL A N LV E  V K++DFG++R   D  Y A  G +  P+KWTAPEA  YG
Sbjct: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYG 440

Query: 736 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQ 795
           R++ +SDVWSFGILL E  + G  PYP + N++  + VE+G R+PCP  CP+++  LM Q
Sbjct: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500

Query: 796 CWAYEPGQRPSFSTIYQELQ 815
           CW  EP +RP+F  +   L+
Sbjct: 501 CWRKEPEERPTFEYLQAFLE 520


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  228 bits (582), Expect = 1e-59
 Identities = 150/380 (39%), Positives = 214/380 (56%), Gaps = 34/380 (8%)

Query: 460 WYHGAIPRAEVAELLVHS----GDFLVRESQG-KQEYVLSVL-WDGLP----RHFIIQSL 509
           WY G I R E   LL+++    G FLVRES+  K  Y LSV  +D       +H+ I+ L
Sbjct: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210

Query: 510 DN--LYRLEGEGFPSIPLLID----------HLLSTQQPLTKKSGVVLHRAVPKDKWVLN 557
           D+   Y      F S+  L+           H L+T  P +K       + + KD W + 
Sbjct: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQT----QGLAKDAWEIP 266

Query: 558 HEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSH 616
            E L L  ++G+G FGEV+ G      T VA+K+ +  T+ P+    FLQEA+++K+  H
Sbjct: 267 RESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEA---FLQEAQVMKKLRH 322

Query: 617 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE-GARLRVKTLLQMVGDAAAGMEYLE 675
             +V+L  V ++ +PIYIV E +  G  L FL+ E G  LR+  L+ M    A+GM Y+E
Sbjct: 323 EKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381

Query: 676 SKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYG 735
               +HRDL A N LV E  V K++DFG++R   D  Y A  G +  P+KWTAPEA  YG
Sbjct: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYG 440

Query: 736 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQ 795
           R++ +SDVWSFGILL E  + G  PYP + N++  + VE+G R+PCP  CP+++  LM Q
Sbjct: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500

Query: 796 CWAYEPGQRPSFSTIYQELQ 815
           CW  EP +RP+F  +   L+
Sbjct: 501 CWRKEPEERPTFEYLQAFLE 520


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  228 bits (581), Expect = 2e-59
 Identities = 142/376 (37%), Positives = 208/376 (55%), Gaps = 26/376 (6%)

Query: 460 WYHGAIPRAEVAELLVHSGD----FLVRESQG-KQEYVLSVL-WDGLP----RHFIIQSL 509
           WY G + R +    L+  G+    FL+RES+  K  Y LS+  WD +     +H+ I+ L
Sbjct: 149 WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKL 208

Query: 510 DN--LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP------KDKWVLNHEDL 561
           DN   Y      F ++  L+ H       L     V+     P      KD W +    L
Sbjct: 209 DNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSL 268

Query: 562 VLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIV 620
            L +++G+G F EV+ G     NT VA+K+ +  T+ P+    FL+EA+I+K+  H  +V
Sbjct: 269 CLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPE---SFLEEAQIMKKLKHDKLV 324

Query: 621 RLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCC 679
           +L  V ++ +PIYIV E +  G  L FL+  EG  L++  L+ M    AAGM Y+E    
Sbjct: 325 QLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNY 383

Query: 680 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 739
           IHRDL + N LV    + KI+DFG++R   D  Y A  G +  P+KWTAPEA  YGR++ 
Sbjct: 384 IHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTI 442

Query: 740 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 799
           +SDVWSFGILL E  + G  PYP ++N++  E VE+G R+PCP+ CP ++  LM  CW  
Sbjct: 443 KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK 502

Query: 800 EPGQRPSFSTIYQELQ 815
           +P +RP+F  +   L+
Sbjct: 503 DPEERPTFEYLQSFLE 518


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  224 bits (571), Expect = 3e-58
 Identities = 141/374 (37%), Positives = 206/374 (55%), Gaps = 26/374 (6%)

Query: 460 WYHGAIPRAEVAELLV--HSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDNLYRLE 516
           W+HG I R +   LL    +G FLVRES     +Y L V  DG   H+ I    +   ++
Sbjct: 82  WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSID 141

Query: 517 GEG-FPSIPLLIDHLLSTQ--------QPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQI 567
            E  F ++  L++H  S          +P   +  V       +  W LN ++L L + I
Sbjct: 142 EEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTI 201

Query: 568 GRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGVC 626
           G+G FG+V  G  R +   VAVK  +     D  A+ FL EA ++ Q  H N+V+L+GV 
Sbjct: 202 GKGEFGDVMLGDYRGNK--VAVKCIKN----DATAQAFLAEASVMTQLRHSNLVQLLGVI 255

Query: 627 TQ-KQPIYIVMELVQGGDFLTFLRTEGAR-LRVKTLLQMVGDAAAGMEYLESKCCIHRDL 684
            + K  +YIV E +  G  + +LR+ G   L    LL+   D    MEYLE    +HRDL
Sbjct: 256 VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDL 315

Query: 685 AARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVW 744
           AARN LV+E NV K+SDFG+++E +     ++    ++PVKWTAPEAL   ++S++SDVW
Sbjct: 316 AARNVLVSEDNVAKVSDFGLTKEAS-----STQDTGKLPVKWTAPEALREKKFSTKSDVW 370

Query: 745 SFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQR 804
           SFGILLWE +S G  PYP +  +     VEKG ++  P+ CP AV+ +M+ CW  +   R
Sbjct: 371 SFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMR 430

Query: 805 PSFSTIYQELQSIR 818
           PSF  + ++L+ I+
Sbjct: 431 PSFLQLREQLEHIK 444


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  224 bits (571), Expect = 3e-58
 Identities = 141/374 (37%), Positives = 206/374 (55%), Gaps = 26/374 (6%)

Query: 460 WYHGAIPRAEVAELLV--HSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDNLYRLE 516
           W+HG I R +   LL    +G FLVRES     +Y L V  DG   H+ I    +   ++
Sbjct: 82  WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSID 141

Query: 517 GEG-FPSIPLLIDHLLSTQ--------QPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQI 567
            E  F ++  L++H  S          +P   +  V       +  W LN ++L L + I
Sbjct: 142 EEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTI 201

Query: 568 GRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGVC 626
           G+G FG+V  G  R +   VAVK  +     D  A+ FL EA ++ Q  H N+V+L+GV 
Sbjct: 202 GKGEFGDVMLGDYRGNK--VAVKCIKN----DATAQAFLAEASVMTQLRHSNLVQLLGVI 255

Query: 627 TQ-KQPIYIVMELVQGGDFLTFLRTEGAR-LRVKTLLQMVGDAAAGMEYLESKCCIHRDL 684
            + K  +YIV E +  G  + +LR+ G   L    LL+   D    MEYLE    +HRDL
Sbjct: 256 VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDL 315

Query: 685 AARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVW 744
           AARN LV+E NV K+SDFG+++E +     ++    ++PVKWTAPEAL   ++S++SDVW
Sbjct: 316 AARNVLVSEDNVAKVSDFGLTKEAS-----STQDTGKLPVKWTAPEALREKKFSTKSDVW 370

Query: 745 SFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQR 804
           SFGILLWE +S G  PYP +  +     VEKG ++  P+ CP AV+ +M+ CW  +   R
Sbjct: 371 SFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMR 430

Query: 805 PSFSTIYQELQSIR 818
           PSF  + ++L+ I+
Sbjct: 431 PSFLQLREQLEHIK 444


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,667,878
Number of Sequences: 37866
Number of extensions: 1520719
Number of successful extensions: 9729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 622
Number of HSP's successfully gapped in prelim test: 526
Number of HSP's that attempted gapping in prelim test: 6402
Number of HSP's gapped (non-prelim): 2169
length of query: 822
length of database: 18,247,518
effective HSP length: 111
effective length of query: 711
effective length of database: 14,044,392
effective search space: 9985562712
effective search space used: 9985562712
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.