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Search of human proteins with 4503269
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503269 deoxycytidine kinase [Homo sapiens]
(260 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503269 deoxycytidine kinase [Homo sapiens] 539 e-153
gi|18426967 deoxyguanosine kinase isoform a precursor [Homo sapi... 254 5e-68
gi|92859641 thymidine kinase 2, mitochondrial [Homo sapiens] 137 7e-33
gi|18426971 deoxyguanosine kinase isoform b precursor [Homo sapi... 118 5e-27
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 32 0.55
gi|30387611 cell division cycle 2-like 6 (CDK8-like) [Homo sapiens] 30 2.1
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 30 2.8
gi|4502745 cyclin-dependent kinase 8 [Homo sapiens] 30 2.8
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 29 3.6
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 29 3.6
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 29 3.6
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 29 3.6
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 29 3.6
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 29 3.6
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 29 3.6
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 29 3.6
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 29 3.6
gi|122891870 melanoma inhibitory activity family, member 3 [Homo... 29 4.7
gi|167614502 protein phosphatase 1, regulatory (inhibitor) subun... 29 4.7
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 28 8.0
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 28 8.0
gi|100913220 alpha 1 type XVI collagen precursor [Homo sapiens] 28 8.0
>gi|4503269 deoxycytidine kinase [Homo sapiens]
Length = 260
Score = 539 bits (1388), Expect = e-153
Identities = 260/260 (100%), Positives = 260/260 (100%)
Query: 1 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN 60
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN
Sbjct: 1 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN 60
Query: 61 VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE 120
VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE
Sbjct: 61 VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE 120
Query: 121 KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA 180
KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA
Sbjct: 121 KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA 180
Query: 181 TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE 240
TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE
Sbjct: 181 TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE 240
Query: 241 DFKDKYESLVEKVKEFLSTL 260
DFKDKYESLVEKVKEFLSTL
Sbjct: 241 DFKDKYESLVEKVKEFLSTL 260
>gi|18426967 deoxyguanosine kinase isoform a precursor [Homo
sapiens]
Length = 277
Score = 254 bits (649), Expect = 5e-68
Identities = 125/263 (47%), Positives = 171/263 (65%), Gaps = 6/263 (2%)
Query: 1 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN 60
MA P S G +++SIEGNIA GKSTFV +L + +W V EPVA W N
Sbjct: 18 MAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTKTYPEWHVATEPVATWQN 77
Query: 61 VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE 120
+Q+ + + ++ GN+L MMY +P RWS+TFQT++ LSR++ QL KL A
Sbjct: 78 IQAAGTQ---KACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFPEKLLQAR 134
Query: 121 KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA 180
KPV FERSVYSDRYIFA NL+E+ +++ EW IYQDWH ++ +F + L G IYLQA
Sbjct: 135 KPVQIFERSVYSDRYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLHGFIYLQA 194
Query: 181 TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE 240
+P+ CL R+Y R R EE+GI L YLE+LH +HE+WL+H+T K +F+ L +P+L LDVN+
Sbjct: 195 SPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPVLVLDVND 254
Query: 241 DFKD---KYESLVEKVKEFLSTL 260
DF + K E L+ +V F+ L
Sbjct: 255 DFSEEVTKQEDLMREVNTFVKNL 277
>gi|92859641 thymidine kinase 2, mitochondrial [Homo sapiens]
Length = 307
Score = 137 bits (346), Expect = 7e-33
Identities = 80/224 (35%), Positives = 114/224 (50%), Gaps = 30/224 (13%)
Query: 24 ISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQ 83
I +EGNIA+GK+T + D EV+ EPV++W NV+ G N L
Sbjct: 95 ICVEGNIASGKTTCLEFFSN-ATDVEVLTEPVSKWRNVR---------------GHNPLG 138
Query: 84 MMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYE 143
+MY RW T QTY QL L+ + V ERS++S RYIF NLY
Sbjct: 139 LMYHDASRWGLTLQTYV-------QLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYR 191
Query: 144 SECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLE 203
S M E ++ + +W DW+ S++L I+YL+ PETC R+ R R EE+ IPLE
Sbjct: 192 SGKMPEVDYVVLSEWFDWILRNMDVSVDL--IVYLRTNPETCYQRLKKRCREEEKVIPLE 249
Query: 204 YLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYE 247
YLE +H+ HE WL+ +L + P+L ++ + + E
Sbjct: 250 YLEAIHHLHEEWLIKGSL-----FPMAAPVLVIEADHHMERMLE 288
>gi|18426971 deoxyguanosine kinase isoform b precursor [Homo
sapiens]
Length = 189
Score = 118 bits (296), Expect = 5e-27
Identities = 63/137 (45%), Positives = 82/137 (59%), Gaps = 3/137 (2%)
Query: 1 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN 60
MA P S G +++SIEGNIA GKSTFV +L + +W V EPVA W N
Sbjct: 18 MAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTKTYPEWHVATEPVATWQN 77
Query: 61 VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE 120
+Q+ + + ++ GN+L MMY +P RWS+TFQT++ LSR++ QL KL A
Sbjct: 78 IQAAGTQ---KACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFPEKLLQAR 134
Query: 121 KPVLFFERSVYSDRYIF 137
KPV FERSVYSDR F
Sbjct: 135 KPVQIFERSVYSDRLHF 151
Score = 35.4 bits (80), Expect = 0.050
Identities = 16/42 (38%), Positives = 26/42 (61%), Gaps = 3/42 (7%)
Query: 222 KTNFDYLQEVPILTLDVNEDFKD---KYESLVEKVKEFLSTL 260
+ +F+ L +P+L LDVN+DF + K E L+ +V F+ L
Sbjct: 148 RLHFEALMNIPVLVLDVNDDFSEEVTKQEDLMREVNTFVKNL 189
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 32.0 bits (71), Expect = 0.55
Identities = 15/32 (46%), Positives = 19/32 (59%)
Query: 205 LEKLHYKHESWLLHRTLKTNFDYLQEVPILTL 236
L+ L Y H+ W+LHR LK N L E +L L
Sbjct: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGVLKL 153
>gi|30387611 cell division cycle 2-like 6 (CDK8-like) [Homo sapiens]
Length = 502
Score = 30.0 bits (66), Expect = 2.1
Identities = 11/29 (37%), Positives = 19/29 (65%)
Query: 194 RNEEQGIPLEYLEKLHYKHESWLLHRTLK 222
R+ + + + L+ +HY H +W+LHR LK
Sbjct: 125 RSMVKSLLYQILDGIHYLHANWVLHRDLK 153
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 29.6 bits (65), Expect = 2.8
Identities = 17/53 (32%), Positives = 24/53 (45%), Gaps = 4/53 (7%)
Query: 52 PEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSR 104
P ARW + ST + E+ T + VLQ+ KP TY CL++
Sbjct: 3140 PRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPS----DAGTYVCLAQ 3188
>gi|4502745 cyclin-dependent kinase 8 [Homo sapiens]
Length = 464
Score = 29.6 bits (65), Expect = 2.8
Identities = 10/20 (50%), Positives = 15/20 (75%)
Query: 203 EYLEKLHYKHESWLLHRTLK 222
+ L+ +HY H +W+LHR LK
Sbjct: 134 QILDGIHYLHANWVLHRDLK 153
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 29.3 bits (64), Expect = 3.6
Identities = 13/39 (33%), Positives = 23/39 (58%)
Query: 196 EEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPIL 234
E + + ++ L + + H++W+LHR LKT+ L IL
Sbjct: 513 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL 551
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 29.3 bits (64), Expect = 3.6
Identities = 13/39 (33%), Positives = 23/39 (58%)
Query: 196 EEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPIL 234
E + + ++ L + + H++W+LHR LKT+ L IL
Sbjct: 523 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL 561
>gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform
a [Homo sapiens]
Length = 1216
Score = 29.3 bits (64), Expect = 3.6
Identities = 13/56 (23%), Positives = 32/56 (57%)
Query: 202 LEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFL 257
++ LE+ K + L+ + + L E P L +++ ++++DK++ L ++ EF+
Sbjct: 1110 IKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFV 1165
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 29.3 bits (64), Expect = 3.6
Identities = 13/39 (33%), Positives = 23/39 (58%)
Query: 196 EEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPIL 234
E + + ++ L + + H++W+LHR LKT+ L IL
Sbjct: 514 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL 552
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 29.3 bits (64), Expect = 3.6
Identities = 13/39 (33%), Positives = 23/39 (58%)
Query: 196 EEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPIL 234
E + + ++ L + + H++W+LHR LKT+ L IL
Sbjct: 523 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL 561
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 29.3 bits (64), Expect = 3.6
Identities = 13/39 (33%), Positives = 23/39 (58%)
Query: 196 EEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPIL 234
E + + ++ L + + H++W+LHR LKT+ L IL
Sbjct: 491 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL 529
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 29.3 bits (64), Expect = 3.6
Identities = 13/39 (33%), Positives = 23/39 (58%)
Query: 196 EEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPIL 234
E + + ++ L + + H++W+LHR LKT+ L IL
Sbjct: 480 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL 518
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 29.3 bits (64), Expect = 3.6
Identities = 13/39 (33%), Positives = 23/39 (58%)
Query: 196 EEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPIL 234
E + + ++ L + + H++W+LHR LKT+ L IL
Sbjct: 269 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL 307
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 29.3 bits (64), Expect = 3.6
Identities = 13/39 (33%), Positives = 23/39 (58%)
Query: 196 EEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPIL 234
E + + ++ L + + H++W+LHR LKT+ L IL
Sbjct: 525 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL 563
>gi|122891870 melanoma inhibitory activity family, member 3 [Homo
sapiens]
Length = 1907
Score = 28.9 bits (63), Expect = 4.7
Identities = 35/145 (24%), Positives = 59/145 (40%), Gaps = 12/145 (8%)
Query: 96 FQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASN---LYESECMNETEW 152
FQ Y + + A L ++ KLK A++ L + D+ AS L +E M +T
Sbjct: 939 FQKYFNVHELEALLQEMSSKLKSAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTRV 998
Query: 153 TIYQDWHDWMNNQFGQSLELDGI-------IYLQATPETCLHRIYLRGRNEEQGIPLEYL 205
+D NN F ++ LD I Y +T E + E G +E +
Sbjct: 999 AENRDLGMNENNIFEEAAVLDDIQDLIYFVRYKHSTAEETATLVMAPPLEEGLGGAMEEM 1058
Query: 206 EKLHYKHESWLLHRTLKTNFDYLQE 230
+ LH +++ +T + N +E
Sbjct: 1059 QPLH--EDNFSREKTAELNVQVPEE 1081
>gi|167614502 protein phosphatase 1, regulatory (inhibitor) subunit
3A [Homo sapiens]
Length = 1122
Score = 28.9 bits (63), Expect = 4.7
Identities = 20/80 (25%), Positives = 32/80 (40%), Gaps = 2/80 (2%)
Query: 44 LCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVL--QMMYEKPERWSFTFQTYAC 101
+C+ E PEPV W V + Q + S K +V + +E P+ T C
Sbjct: 230 ICQKKEQEPEPVKPWKEVPNRQIKGCLKVKSSKEESSVTSEENNFENPKNTDTYIPTIIC 289
Query: 102 LSRIRAQLASLNGKLKDAEK 121
+ L + N +KD +
Sbjct: 290 SHEDKEDLEASNRNVKDVNR 309
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 28.1 bits (61), Expect = 8.0
Identities = 28/107 (26%), Positives = 43/107 (40%), Gaps = 23/107 (21%)
Query: 117 KDAEKPVLFFERSVYSDRYIFASNLYESEC-------MNETEWTIYQDWHDW-----MNN 164
+D E+P +E S Y+D++ S YE M E +W+ Y D + +N
Sbjct: 972 RDLEQPTYRYESSSYTDQF---SRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDN 1028
Query: 165 QFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYK 211
Q Q L+ + PE R Y E+ PL Y + Y+
Sbjct: 1029 QHSQDLD------SRQHPEESSERGYF--PRFEEPAPLSYDSRPRYE 1067
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 28.1 bits (61), Expect = 8.0
Identities = 28/107 (26%), Positives = 43/107 (40%), Gaps = 23/107 (21%)
Query: 117 KDAEKPVLFFERSVYSDRYIFASNLYESEC-------MNETEWTIYQDWHDW-----MNN 164
+D E+P +E S Y+D++ S YE M E +W+ Y D + +N
Sbjct: 1052 RDLEQPTYRYESSSYTDQF---SRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDN 1108
Query: 165 QFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYK 211
Q Q L+ + PE R Y E+ PL Y + Y+
Sbjct: 1109 QHSQDLD------SRQHPEESSERGYF--PRFEEPAPLSYDSRPRYE 1147
>gi|100913220 alpha 1 type XVI collagen precursor [Homo sapiens]
Length = 1604
Score = 28.1 bits (61), Expect = 8.0
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 6/66 (9%)
Query: 175 IIYLQATPETC-LHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPI 233
I+ L A P T R++ RG EE + L L K H ++W L + N P
Sbjct: 76 ILRLGAAPVTQPTRRVFPRGLPEEFALVLTLLLKKHTHQKTWYLFQVTDAN-----GYPQ 130
Query: 234 LTLDVN 239
++L+VN
Sbjct: 131 ISLEVN 136
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,478,316
Number of Sequences: 37866
Number of extensions: 453981
Number of successful extensions: 1224
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1199
Number of HSP's gapped (non-prelim): 26
length of query: 260
length of database: 18,247,518
effective HSP length: 100
effective length of query: 160
effective length of database: 14,460,918
effective search space: 2313746880
effective search space used: 2313746880
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.