Search of human proteins with 4503219

Search of human proteins with 4503219

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide
19 [Homo sapiens]
         (490 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   997   0.0  
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   919   0.0  
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   852   0.0  
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   806   0.0  
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   711   0.0  
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   603   e-173
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   518   e-147
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   515   e-146
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   510   e-144
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   498   e-141
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   490   e-138
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   425   e-119
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   420   e-117
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   361   e-100
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   347   2e-95
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   330   2e-90
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   308   6e-84
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   298   6e-81
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   291   7e-79
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   230   2e-60
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   228   1e-59
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  202   4e-52
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   196   4e-50
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   171   1e-42
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   154   2e-37
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   127   2e-29
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   123   3e-28
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   122   6e-28
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   119   5e-27
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   118   1e-26

>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  997 bits (2577), Expect = 0.0
 Identities = 490/490 (100%), Positives = 490/490 (100%)

Query: 1   MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60
           MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
Sbjct: 1   MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60

Query: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120
           YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
Sbjct: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240
           IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
Sbjct: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240

Query: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300
           ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
Sbjct: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300

Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360
           TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID
Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360

Query: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420
           LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
Sbjct: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420

Query: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480
           KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
Sbjct: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480

Query: 481 PFYQLCFIPV 490
           PFYQLCFIPV
Sbjct: 481 PFYQLCFIPV 490


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  919 bits (2374), Expect = 0.0
 Identities = 448/490 (91%), Positives = 467/490 (95%)

Query: 1   MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60
           MD  VVLVLCLSCLLLLS+WRQSSGRGKLPPGPTPLPVIGNILQI IKD+SKSLTNLSK+
Sbjct: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

Query: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120
           YGPVFTLYFGL+ +VVLHGYE VKEALIDLGEEFSGRG FPLAERANRGFGIVFSNGK+W
Sbjct: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240
           IIF KRFDYKDQQFLNLMEKLNENI+I+S+PWIQICNNF  IIDYFPGTHNKLLKN+AFM
Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240

Query: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300
           +S ILEKVKEHQESMD+NNP+DFIDCFL+KMEKEK NQ SEFTIE+L  TA DL GAGTE
Sbjct: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300

Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360
           TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR HMPYTDAVVHEVQRYID
Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360

Query: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420
           L+PTSLPHAVTCD+KFRNYLIPKGTTIL SLTSVLHDNKEFPNPEMFDP HFLDEGGNFK
Sbjct: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420

Query: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480
           KS YFMPFSAGKRICVGE LA MELFLFLT ILQNFNLKSL+DPK+LDTTPVVNGFASVP
Sbjct: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480

Query: 481 PFYQLCFIPV 490
           PFYQLCFIPV
Sbjct: 481 PFYQLCFIPV 490


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  852 bits (2202), Expect = 0.0
 Identities = 396/490 (80%), Positives = 450/490 (91%)

Query: 1   MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60
           MDP V LVLCLSCL LLS+WRQSSGRG+LP GPTPLP+IGNILQ+D+KD+SKSLTN SK+
Sbjct: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120
           YGPVFT+YFGL+ +VVLHGYE VKEALID GEEFSGRG FP+AE+ N+G GI+FSNGKRW
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRF LMTLRNFGMGKRSIEDRVQEEARCLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240
           +IF  RFDYKDQ+FLNLMEK NEN+RI+S+PWIQ+CNNFP +IDY PG+HNK+ +N A++
Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240

Query: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300
           +S +LE++KEHQES+D+N+ RDFIDCFLIKME+EK NQQSEFT+E+L+ T  D+ GAGTE
Sbjct: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300

Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360
           TTSTTLRY LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDR HMPYTDAVVHE+QRYID
Sbjct: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360

Query: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420
           L+PT+LPHAVTCDVKF+NYLIPKGTTI+TSLTSVLH++KEFPNPEMFDP HFLD+ GNFK
Sbjct: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420

Query: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480
           KS+YFMPFSAGKR+C+GEGLARMELFLFLT ILQNFNLKS +DPKD+D TP+ N F  VP
Sbjct: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480

Query: 481 PFYQLCFIPV 490
           P YQLCFIPV
Sbjct: 481 PLYQLCFIPV 490


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  806 bits (2083), Expect = 0.0
 Identities = 383/490 (78%), Positives = 430/490 (87%)

Query: 1   MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60
           M+PFVVLVLCLS +LL S+WRQS  R KLPPGPTPLP+IGN+LQID+KD+ KS TN SK+
Sbjct: 1   MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV 60

Query: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120
           YGPVFT+YFG+  +VV HGYE VKEALID GEEFSGRG+ P+++R  +G GI+ SNGKRW
Sbjct: 61  YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRFSL TLRNFGMGKRSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240
           ++FQKRFDYKDQ FL LM++ NEN RI+++PWIQ+CNNFP +ID FPGTHNK+LKN+A  
Sbjct: 181 VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT 240

Query: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300
            S I EKVKEHQ S+D+NNPRDFIDCFLIKME+EK NQ+SEF IENLV T ADL  AGTE
Sbjct: 241 RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE 300

Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360
           TTSTTLRY LLLLLKHPEVTAKVQEEI+ VIGR+RSPCMQDR HMPYTDAVVHE+QRY D
Sbjct: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD 360

Query: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420
           L+PT +PHAVT D KFRNYLIPKGTTI+  LTSVLHD+KEFPNP +FDP HFLD+ GNFK
Sbjct: 361 LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK 420

Query: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480
           KS+YFMPFSAGKRIC GEGLARMELFLFLT ILQNFNLKS+ D K+L+TT V  G  S+P
Sbjct: 421 KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP 480

Query: 481 PFYQLCFIPV 490
           P YQ+CFIPV
Sbjct: 481 PSYQICFIPV 490


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  711 bits (1836), Expect = 0.0
 Identities = 351/490 (71%), Positives = 391/490 (79%), Gaps = 59/490 (12%)

Query: 1   MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60
           MDP V LVLCLSCL LLS+WRQSSGRG+LP GPTPLP+IGNILQ+D+KD+SKSLTN SK+
Sbjct: 1   MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120
           YGPVFT+YFGL+ +VVLHGYE VKEALID GEEFSGRG FP+AE+ N+G GI+FSNGKRW
Sbjct: 61  YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           KEIRRF LMTLRNFGMGKRSIEDRVQEEARCLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240
           +IF  RFDYKDQ+FLNLME                                K  +NL  +
Sbjct: 181 VIFHDRFDYKDQRFLNLME--------------------------------KFNENLRIL 208

Query: 241 ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE 300
            S  ++                           EK NQQSEFT+E+L+ T  D+ GAGTE
Sbjct: 209 SSPWIQ---------------------------EKHNQQSEFTVESLIATVTDMFGAGTE 241

Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID 360
           TTSTTLRY LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDR HMPYTDAVVHE+QRYID
Sbjct: 242 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 301

Query: 361 LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420
           L+PT+LPHAVTCDVKF+NYLIPKGTTI+TSLTSVLH++KEFPNPEMFDP HFLD+ GNFK
Sbjct: 302 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 361

Query: 421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP 480
           KS+YFMPFSAGKR+C+GEGLARMELFLFLT ILQNFNLKS +DPKD+D TP+ N F  VP
Sbjct: 362 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 421

Query: 481 PFYQLCFIPV 490
           P YQLCFIPV
Sbjct: 422 PLYQLCFIPV 431


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  603 bits (1556), Expect = e-173
 Identities = 280/485 (57%), Positives = 370/485 (76%), Gaps = 1/485 (0%)

Query: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           V L++  + LLL+S+WRQ      LPPGP PLP+IGN+ Q+++K++ KS T L++ +GPV
Sbjct: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67

Query: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124
           FTLY G +RMVV+HGY+ VKEAL+D  +EFSGRG  P A  A+R  GI+F+NG  WK+IR
Sbjct: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIR 126

Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184
           RFSL TLRN+GMGK+  E R+Q EA  L+E LRKT+  P DPTF++GCAPCNVI  I+F+
Sbjct: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186

Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244
           K FDY D++FL LM   NEN  ++STPW+Q+ NNFP+ + Y PG+H K++KN+A ++  +
Sbjct: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246

Query: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304
            E+VKEH +S+D N PRD  DC L++MEKEK + +  +T++ + +T ADL  AGTETTST
Sbjct: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306

Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364
           TLRY LL+L+K+PE+  K+ EEI+RVIG +R P ++DR  MPY DAVVHE+QR+I L+P+
Sbjct: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366

Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424
           +LPH  T D  FR YLIPKGT ++ +L SVL+DN+EFP+PE F P HFL+E G FK S+Y
Sbjct: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426

Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484
           F PFS GKR+C GEGLARMELFL L  ILQ+FNLK L+DPKD+D +P+  GF  +PP Y+
Sbjct: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486

Query: 485 LCFIP 489
           LC IP
Sbjct: 487 LCVIP 491


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  518 bits (1335), Expect = e-147
 Identities = 252/485 (51%), Positives = 344/485 (70%)

Query: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           V L+ CL+ ++L+S+WRQ   RGKLPPGPTPLP IGN LQ++ + +  SL  +S+ YGPV
Sbjct: 9   VTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124
           FT++ G  R+VVL G++ VKEAL+D  EEFSGRG     +   +G+G+ FSNG+R K++R
Sbjct: 69  FTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLR 128

Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184
           RFS+ TLR FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI SI+F 
Sbjct: 129 RFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244
            RFDY+D++FL+L+  +  + +  +T   Q+   F +++ + PG   +  K L  +E  I
Sbjct: 189 DRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFI 248

Query: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304
            +KV+ +Q ++D N+PRDFID FLI+M++E++N  +EF ++NLV+T  +L  AGTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVST 308

Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364
           TLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR  MPYT+AV+HE+QR+ D++P 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPM 368

Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424
            L H V  D KFR++ +PKGT +   L SVL D + F NP  F+P+HFLD+ G FKKS+ 
Sbjct: 369 GLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDA 428

Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484
           F+PFS GKR C GEGLARMELFLF T I+QNF  KS   PKD+D +P   GFA++P  Y 
Sbjct: 429 FVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYT 488

Query: 485 LCFIP 489
           + F+P
Sbjct: 489 MSFLP 493


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  515 bits (1327), Expect = e-146
 Identities = 248/485 (51%), Positives = 348/485 (71%), Gaps = 3/485 (0%)

Query: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           ++L+L L CLLL      S  +GKLPPGP PL ++GN+L +  +D+  SLT LSK YG +
Sbjct: 9   LLLLLALVCLLLTL---SSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSM 65

Query: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124
           +T++ G  R+VVL GY+ VKEAL+D GEEFSGRG +P      +G GI FS+G RWK +R
Sbjct: 66  YTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLR 125

Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184
           +FS+  LRNFGMGKRSIE+R+ EE   L+ ELRKT+  P DPTF+L  +  N+ICS++F 
Sbjct: 126 QFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFG 185

Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244
            RFDY D++ L ++  +N+N +I+S+PW ++ + FP+++D+ PG H ++ +N   +   I
Sbjct: 186 SRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLI 245

Query: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304
              V +HQ S+D  +PRDFI CFL KM +EK++  S F ++ L++T  +LL  GT+T ST
Sbjct: 246 AHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVST 305

Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364
           TL +A L L+K+P+V A+VQEEI+ V+GR R P ++DR  MPYTDAV+HEVQR+ D+IP 
Sbjct: 306 TLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPM 365

Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424
           +LPH VT D  FR +LIPKGT ++T L +V +D  +F  P+ F+P HFLD   +FKKS  
Sbjct: 366 NLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPA 425

Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484
           FMPFSAG+R+C+GE LARMELFL+LT ILQ+F+L+ L  P+D+D TP+ +G  ++P  +Q
Sbjct: 426 FMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQ 485

Query: 485 LCFIP 489
           LC  P
Sbjct: 486 LCLRP 490


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  510 bits (1313), Expect = e-144
 Identities = 250/485 (51%), Positives = 345/485 (71%)

Query: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           V L++CL+ ++L+S+W+Q   +GKLPPGPTPLP IGN LQ++ + +  SL  +S+ YGPV
Sbjct: 9   VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68

Query: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124
           FT++ G  R+VVL G++ V+EAL+D  EEFSGRG     +   +G+G+VFSNG+R K++R
Sbjct: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLR 128

Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184
           RFS+ TLR+FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI SI+F 
Sbjct: 129 RFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244
            RFDYKD++FL+L+  +    +  ST   Q+   F +++ + PG   +  + L  +E  I
Sbjct: 189 DRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFI 248

Query: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304
            +KV+ +Q ++D N+PRDFID FLI+M++E++N  +EF ++NLV+T  +L   GTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVST 308

Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364
           TLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR  MPY +AV+HE+QR+ D+IP 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 368

Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424
           SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P+HFL+E G FKKS+ 
Sbjct: 369 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDA 428

Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484
           F+PFS GKR C GEGLARMELFLF T ++QNF LKS   PKD+D +P   GFA++P  Y 
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT 488

Query: 485 LCFIP 489
           + F+P
Sbjct: 489 MSFLP 493


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  498 bits (1282), Expect = e-141
 Identities = 243/485 (50%), Positives = 340/485 (70%)

Query: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           V L+ CL+ ++L+S+W+Q   RGKLPPGPTPLP IGN LQ++ + +  S+   S+ YGPV
Sbjct: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPV 68

Query: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124
           FT++ G  R+VVL G++ V+EAL+D  EEFSGRG     +   +G+G+ FSNG+R K++ 
Sbjct: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLL 128

Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184
           RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI SI+F 
Sbjct: 129 RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 188

Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244
            RFDY+D++FL+L+  +    +  ST   Q+   F +++ + PG   +  K L  +E  I
Sbjct: 189 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 248

Query: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304
            +KV+ +Q ++D N+P+DFID FLI M++E++N  +EF ++NL+++  +L  AGTET ST
Sbjct: 249 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 308

Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364
           TLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR  MPY +AV+HE+QR+ D+IP 
Sbjct: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 368

Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424
           SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P+HFLD+ G FKKS+ 
Sbjct: 369 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 428

Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484
           F+PFS GKR C GEGLARMELFLF T ++QNF LKS   PKD+D +P    FA++P  Y 
Sbjct: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 488

Query: 485 LCFIP 489
           + F+P
Sbjct: 489 MSFLP 493


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  490 bits (1261), Expect = e-138
 Identities = 237/490 (48%), Positives = 335/490 (68%), Gaps = 1/490 (0%)

Query: 1   MDPFVVLVLCL-SCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSK 59
           M+  V+L L L + LLLL + R  +   +LPPGP PLP++GN+LQ+D + + KS     +
Sbjct: 1   MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60

Query: 60  IYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKR 119
            YG VFT++ G   +V+L G E ++EAL+D  E FSGRG   + +   RG+G++F+NG R
Sbjct: 61  KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120

Query: 120 WKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVIC 179
           WK +RRFS+ T+R+FGMGKRS+E+R+QEEA+CL+EELRK+K +  DPTF+      N+IC
Sbjct: 121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180

Query: 180 SIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAF 239
           SI+F KRF Y+DQ+FL ++    +   ++S+ + Q+   F   + YFPG H ++ KNL  
Sbjct: 181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240

Query: 240 MESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGT 299
           + + I   V++H+E++D + P+D ID +L+ MEKEK N  SEF+ +NL +    L  AGT
Sbjct: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300

Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359
           ETTSTTLRY  LL+LK+P V  +V  EIE+VIG +R P + DR  MPYT+AV++E+QR+ 
Sbjct: 301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360

Query: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF 419
           DL+P  +PH VT    FR Y+IPK T +   L++ LHD   F  P+ F+P HFLD  G  
Sbjct: 361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420

Query: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASV 479
           KK+  F+PFS GKRIC+GEG+AR ELFLF T ILQNF++ S + P+D+D TP   G   +
Sbjct: 421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480

Query: 480 PPFYQLCFIP 489
           PP YQ+ F+P
Sbjct: 481 PPTYQIRFLP 490


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  425 bits (1092), Expect = e-119
 Identities = 218/485 (44%), Positives = 306/485 (63%), Gaps = 51/485 (10%)

Query: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           V L+ CL+ ++L+S+W+Q   RGKLPPGPTPLP IGN LQ++ + +  S+  +S+     
Sbjct: 9   VALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKVSQ----- 63

Query: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124
                                                         G+ FSNG+R K++ 
Sbjct: 64  ----------------------------------------------GVAFSNGERAKQLL 77

Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184
           RF++ TLR+FG+GKR IE+R+QEE+  L+E +R T  +  DPTF L     NVI SI+F 
Sbjct: 78  RFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFG 137

Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244
            RFDY+D++FL+L+  +    +  ST   Q+   F +++ + PG   +  K L  +E  I
Sbjct: 138 DRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFI 197

Query: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304
            +KV+ +Q ++D N+P+DFID FLI M++E++N  +EF ++NL+++  +L  AGTET ST
Sbjct: 198 AKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVST 257

Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364
           TLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR  MPY +AV+HE+QR+ D+IP 
Sbjct: 258 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPM 317

Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424
           SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P+HFLD+ G FKKS+ 
Sbjct: 318 SLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDA 377

Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484
           F+PFS GKR C GEGLARMELFLF T ++QNF LKS   PKD+D +P    FA++P  Y 
Sbjct: 378 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYT 437

Query: 485 LCFIP 489
           + F+P
Sbjct: 438 MSFLP 442


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  420 bits (1080), Expect = e-117
 Identities = 217/482 (45%), Positives = 313/482 (64%), Gaps = 3/482 (0%)

Query: 7   LVLCLSCLLLLSIWRQSS-GRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVF 65
           L+L L+ LLLL++    +  RG LPPGPTPLP++GN+LQ+    +   L  LSK YGPVF
Sbjct: 9   LLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVF 68

Query: 66  TLYFGLER-MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124
           T+Y G  R +VVL G E V+EAL    EEFSGRG   + E    G G+ FSNG+RW+++R
Sbjct: 69  TIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLR 128

Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184
           +F+++ LR+ GMGKR  E+ +Q EARCLVE  + T+  P DP+ +L  A  NV+CS++F 
Sbjct: 129 KFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFG 188

Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244
            RF Y+D++F  ++      +  VS+   Q    F   +   PG H +LL +++ + +  
Sbjct: 189 LRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFT 248

Query: 245 LEKVKEHQESMDINNP-RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTS 303
           + +V++HQ ++D + P RD +D FL+KM +E+QN  +EFT +N+++T   LL AGT T S
Sbjct: 249 VRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVS 308

Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIP 363
           TT+ Y LLLL+K+P V   V+EE+ R +G  ++P + DR  +PYTDAV+HE QR + L+P
Sbjct: 309 TTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVP 368

Query: 364 TSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN 423
             +P  +    +FR Y +P+GT +   L S+LHD   F +PE F+P  FLD  G F+K  
Sbjct: 369 MGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHE 428

Query: 424 YFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFY 483
            F+PFS GKR+C+GEGLA+ ELFLF T ILQ F+L+S   P  L   P V+G  ++PP +
Sbjct: 429 AFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAF 488

Query: 484 QL 485
           QL
Sbjct: 489 QL 490


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  361 bits (926), Expect = e-100
 Identities = 192/460 (41%), Positives = 276/460 (60%), Gaps = 3/460 (0%)

Query: 30  PPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 89
           PPGP  LP +GN   +D +     +    K YG +F+L  G    V++ G  ++KEALI 
Sbjct: 44  PPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIH 103

Query: 90  LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149
           + + F  R   P+ E   +  G++ S+G+ WKE RRF+L  LRNFG+GK+S+E+R+QEEA
Sbjct: 104 MDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEA 163

Query: 150 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVS 209
           + L E +++    P DP F +  A  N+ICSI F +RF+Y+D  F  L++ L+E   + +
Sbjct: 164 QHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEA 223

Query: 210 TPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLI 269
           +   Q+ N FP I+ + PG H  L  N   ++  +   + +H++  +    RDFID +L 
Sbjct: 224 SKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLK 283

Query: 270 KMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329
           +M K   N  S F  ENL+ +  DL  AGTETTSTTLR+ALL +  +PE+  KVQ EI+R
Sbjct: 284 EMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDR 343

Query: 330 VIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILT 389
           VIG+ + P    R  MPYT+AV+HEVQR  ++IP ++P  VT D     Y +PKGT ILT
Sbjct: 344 VIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILT 403

Query: 390 SLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFL 449
           +LT++  D  E+  P+ F+P HFL E G FKK   FMPFS GKR C+GE LAR ELF+F 
Sbjct: 404 NLTALHRDPTEWATPDTFNPDHFL-ENGQFKKREAFMPFSIGKRACLGEQLARTELFIFF 462

Query: 450 TFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIP 489
           T ++Q F  +   + K   +     G    P  ++LC +P
Sbjct: 463 TSLMQKFTFRPPNNEK--LSLKFRMGITISPVSHRLCAVP 500


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  347 bits (889), Expect = 2e-95
 Identities = 194/490 (39%), Positives = 286/490 (58%), Gaps = 7/490 (1%)

Query: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           + +++ +  LL+  + R+     + PPGP PLP +GN+L +D ++       L + +G V
Sbjct: 9   LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68

Query: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERAN---RGFGIVFSN-GKRW 120
           F+L      +VVL+G   V+EAL+  GE+ + R   P+ +      R  G+  +  G  W
Sbjct: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAW 128

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           +E RRFS+ TLRN G+GK+S+E  V EEA CL          P  P  +L  A  NVI S
Sbjct: 129 REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS 188

Query: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240
           +   +RF+Y D +FL L++   E ++  S    ++ N  P ++ + P    K+L+     
Sbjct: 189 LTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAF 247

Query: 241 ESDILEKVKEHQESMD-INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGT 299
            + + E + EH+ + D    PRD  + FL +MEK K N +S F  ENL I  ADL  AG 
Sbjct: 248 LTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGM 307

Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359
            TTSTTL + LLL++ HP+V  +VQ+EI+ VIG+ R P M D+ HMPYT AV+HEVQR+ 
Sbjct: 308 VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFG 367

Query: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF 419
           D++P  + H  + D++ + + IPKGTT++T+L+SVL D   +  P  F P HFLD  G+F
Sbjct: 368 DIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF 427

Query: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASV 479
            K   F+PFSAG+R C+GE LARMELFLF T +LQ+F+  S+   +   +   V  F   
Sbjct: 428 VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVT 486

Query: 480 PPFYQLCFIP 489
           P  Y+LC +P
Sbjct: 487 PSPYELCAVP 496


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  330 bits (845), Expect = 2e-90
 Identities = 180/492 (36%), Positives = 289/492 (58%), Gaps = 16/492 (3%)

Query: 8   VLCLSCLLLLSIW-------RQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI 60
           +L L  L LL +W       +  S   + PPGP PLP++GN+  + +    +SL  LS+ 
Sbjct: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62

Query: 61  YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW 120
           YGPVFT++ G ++ VVL G+E VKEAL   G+E + R    + +   RG GI FS+G RW
Sbjct: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
           +  R+F++  L + G+G+  + D++ +E +CL  +L   +  P  P  +LG AP N+  +
Sbjct: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181

Query: 181 IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM 240
           ++F +RFDY+D  F++L+  ++E + ++ +P +Q+ N +P  +      H  +L+ +  +
Sbjct: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPW-LGALLQLHRPVLRKIEEV 240

Query: 241 ESDILEKVKEHQESMDINNP-RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGT 299
            + +   ++  +  +   +P   ++D  +   + +  + +  F   N V    D++ AGT
Sbjct: 241 RAILRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMVMAGT 298

Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYI 359
           ETTS TL++A LL+ +HP+V  +VQEE++RV+G  R+P ++D+  +PYT AV+HEVQR+I
Sbjct: 299 ETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFI 358

Query: 360 DLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNF 419
            L+P  +P     D +   +L+PKGT ++  LTSVL D  ++  P  F+P HFLD  G+F
Sbjct: 359 TLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHF 417

Query: 420 KKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL--KSLIDPKDLDTTPVVNGFA 477
            K   F+PFSAG+R+CVGE LAR ELFL    +LQ + L     + P  LDTTP    F 
Sbjct: 418 VKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTP-ARAFT 476

Query: 478 SVPPFYQLCFIP 489
             P    LC +P
Sbjct: 477 MRPRAQALCAVP 488


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  308 bits (790), Expect = 6e-84
 Identities = 181/477 (37%), Positives = 270/477 (56%), Gaps = 29/477 (6%)

Query: 7   LVLC-LSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKS------------ 53
           L+LC L  LL  S  R+   RG +PPGPTP P++GN   + +    +             
Sbjct: 37  LLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95

Query: 54  -----------LTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPL 102
                      L +L+++YG +F+ + G   +VVL  +  V+EAL+   E FS R   PL
Sbjct: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155

Query: 103 AERANRGFGIVFSN-GKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKA 161
                +  G+VF++ G  W++ R+FS  TLR+FG+GK S+E ++ EE + +  E++K   
Sbjct: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGE 215

Query: 162 SPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPT 221
            P  P  I+  A  N+ICS+ F +RFDY + +F  ++  ++  + I     + + N  P 
Sbjct: 216 DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPW 275

Query: 222 IIDYFPGTHNKLLKNLAFMESDILEKV-KEHQESMDINNPRDFIDCFLIKMEKE-KQNQQ 279
           +  Y P    K L+ +    +  L+K+ K+HQES+D  NP+DFID +L+ ME+E K N  
Sbjct: 276 LY-YLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334

Query: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339
           S F  E L     DL  AGT+TT+ +L + LL +  +P+V  KV EEIERVIG NR+P +
Sbjct: 335 SSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSL 394

Query: 340 QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNK 399
            D+  MPYT+A + EVQR   ++P ++PH  + +   + Y IPKGT IL +L SV  D  
Sbjct: 395 TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPA 454

Query: 400 EFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456
            +  PE F P  FLD+ G   K   F+PF  GKR+C+GE LA+MELFL    ++Q+F
Sbjct: 455 IWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  298 bits (764), Expect = 6e-81
 Identities = 166/455 (36%), Positives = 262/455 (57%), Gaps = 4/455 (0%)

Query: 7   LVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKS--LTNLSKIYGPV 64
           L L L  L +  + +Q    G  PPGP  LP IGNI  +          +   S++YG +
Sbjct: 18  LFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEI 76

Query: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSN-GKRWKEI 123
           F+L  G    VVL+GY+VVKE L+   E F+ R   PL  +  +  G++ S  G+ W + 
Sbjct: 77  FSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDH 136

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183
           RR ++ + R FG G++S E ++ EE +   + +   K  P D   ++  A  N+   IIF
Sbjct: 137 RRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIF 196

Query: 184 QKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESD 243
            +RF Y+D  F +++E  +EN+ + ++  + + N FP I     G H +L +N A +   
Sbjct: 197 GERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDF 256

Query: 244 ILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTS 303
           +   +++   +     P+ F+D +L +M++ K +  S F+ ENL+ +  +L+ AGTETT+
Sbjct: 257 LSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTT 316

Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIP 363
             LR+A+L +  +P +  +VQ+EI+ ++G N  P   D+  MPYT+AV+HEV R+ +++P
Sbjct: 317 NVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVP 376

Query: 364 TSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN 423
             + HA + D   R Y IPKGTT++T+L SV  D K + +PE+F P  FLD  G F K  
Sbjct: 377 LGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKE 436

Query: 424 YFMPFSAGKRICVGEGLARMELFLFLTFILQNFNL 458
             +PFS G+R C+GE LARME+FLF T +LQ F+L
Sbjct: 437 ALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 471


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  291 bits (746), Expect = 7e-79
 Identities = 174/486 (35%), Positives = 260/486 (53%), Gaps = 50/486 (10%)

Query: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           + +++ +  LL+  + R+     + PPGP PLP +GN+L +D ++       L + +G V
Sbjct: 9   LAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDV 68

Query: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124
           F+L      +VVL+G   V+EAL+  GE+ + R   P+ +                    
Sbjct: 69  FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQI------------------- 109

Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184
                     G G RS                   +  P  P  +L  A  NVI S+   
Sbjct: 110 ---------LGFGPRS-------------------QGRPFRPNGLLDKAVSNVIASLTCG 141

Query: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244
           +RF+Y D +FL L++   E ++  S    ++ N  P ++ + P    K+L+      + +
Sbjct: 142 RRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRFQKAFLTQL 200

Query: 245 LEKVKEHQESMD-INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTS 303
            E + EH+ + D    PRD  + FL +MEK K N +S F  ENL I  ADL  AG  TTS
Sbjct: 201 DELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAGMVTTS 260

Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIP 363
           TTL + LLL++ HP+V  +VQ+EI+ VIG+ R P M D+ HMPYT AV+HEVQR+ D++P
Sbjct: 261 TTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVP 320

Query: 364 TSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSN 423
             + H  + D++ + + IPKGTT++T+L+SVL D   +  P  F P HFLD  G+F K  
Sbjct: 321 LGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPE 380

Query: 424 YFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFY 483
            F+PFSAG+R C+GE LARMELFLF T +LQ+F+  S+   +   +   V  F   P  Y
Sbjct: 381 AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVTPSPY 439

Query: 484 QLCFIP 489
           +LC +P
Sbjct: 440 ELCAVP 445


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  230 bits (587), Expect = 2e-60
 Identities = 148/452 (32%), Positives = 233/452 (51%), Gaps = 28/452 (6%)

Query: 30  PPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 89
           PPGP   P+IGN   +  +    S   L++ YG VF +  G   +VVL+G   + +AL+ 
Sbjct: 51  PPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQ 109

Query: 90  LGEEFSGRGHFPLAERANRGFGIVFSN-GKRWKEIRRFSLMTLRNF----GMGKRSIEDR 144
            G  F+ R  F      + G  + F +  + WK  RR +   +RNF       ++ +E  
Sbjct: 110 QGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGH 169

Query: 145 VQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLN 202
           V  EAR LV  L +  A     DP  +   A  NV+ ++ F  R+ + D +F  L+    
Sbjct: 170 VLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNE 229

Query: 203 ENIRIVST-------PWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESM 255
           E  R V         PW+Q    FP  +        +L +N +   + IL+K   H ES+
Sbjct: 230 EFGRTVGAGSLVDVMPWLQY---FPNPVRTVFREFEQLNRNFS---NFILDKFLRHCESL 283

Query: 256 DINN-PRDFIDCFLIKMEKEKQNQQ----SEFTIENLVITAADLLGAGTETTSTTLRYAL 310
                PRD +D F++  EK+         +   +EN+  T  D+ GA  +T ST L++ L
Sbjct: 284 RPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLL 343

Query: 311 LLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 370
           LL  ++P+V  +VQ E+++V+GR+R PCM D+ ++PY  A ++E  R+   +P ++PHA 
Sbjct: 344 LLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHAT 403

Query: 371 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK--SNYFMPF 428
           T +     Y IPK T +  +  SV HD  ++PNPE FDP  FLD+ G   K  ++  M F
Sbjct: 404 TANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIF 463

Query: 429 SAGKRICVGEGLARMELFLFLTFILQNFNLKS 460
           S GKR C+GE L++M+LFLF++ +    + ++
Sbjct: 464 SVGKRRCIGEELSKMQLFLFISILAHQCDFRA 495


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  228 bits (581), Expect = 1e-59
 Identities = 148/462 (32%), Positives = 241/462 (52%), Gaps = 23/462 (4%)

Query: 28  KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 87
           K PPGP   P+IG++L +  K+   +L+ +S+ YG V  +  G   +VVL G + +++AL
Sbjct: 38  KNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQAL 96

Query: 88  IDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGMGKRS----- 140
           +  G++F GR         + G  + FS  +G  W   RR +   L++F +         
Sbjct: 97  VRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS 156

Query: 141 --IEDRVQEEARCLVEELRKTKASP--CDPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 196
             +E+ V +EA  L+  L++  A P   +P   +  +  NVIC+I F +R+D+  Q+ L+
Sbjct: 157 CYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLS 216

Query: 197 LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQESM 255
           L+   N    +V +       +F  I+ Y P       K+L       ++K VKEH ++ 
Sbjct: 217 LVNLNNNFGEVVGSGNPA---DFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF 273

Query: 256 DINNPRDFIDCFLIKMEKEKQ---NQQSEFTIENLVITAADLLGAGTETTSTTLRYALLL 312
           +  + RD  D  LI+  +EKQ   N   + + E ++    DL GAG +T +T + ++L+ 
Sbjct: 274 EKGHIRDITDS-LIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 332

Query: 313 LLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC 372
           L+ +P V  K+QEE++ VIGR+R P + DR H+PY +A + E  R+   +P ++PH+ T 
Sbjct: 333 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR 392

Query: 373 DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK--SNYFMPFSA 430
           D   + + IPKG  +  +   + HD K + NP  F P  FL   G   K  S   + F  
Sbjct: 393 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 452

Query: 431 GKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472
           GKR C+GE +AR E+FLFL  +LQ       +  K +D TP+
Sbjct: 453 GKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPI 493


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  202 bits (515), Expect = 4e-52
 Identities = 141/474 (29%), Positives = 240/474 (50%), Gaps = 36/474 (7%)

Query: 11  LSCLLLLSI----WRQSSGRG-KLPPGPTPLPVIGNILQIDIKD-VSKSLTNLSKIYGPV 64
           L  LLLL++    W +    G K P     LP++G++  +     +  +   L K YGP+
Sbjct: 4   LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPI 63

Query: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERA-NRGFGIVFSN-GKRWKE 122
           +++  G +  V++  +++ KE LI  G++FSGR      + A N   GI F++ G  W+ 
Sbjct: 64  YSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQL 123

Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182
            RR ++ T   F  G + +E  + +E   L + L        D +F +  A  NVI  I 
Sbjct: 124 HRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLIC 183

Query: 183 FQKRFDYKDQQFLNLMEKLNENI--------RIVSTPWIQICNNFPTIIDYFPGTHNKLL 234
           F   +   D + LN+++  NE I         +   PW++I          FP    + L
Sbjct: 184 FNTSYKNGDPE-LNVIQNYNEGIIDNLSKDSLVDLVPWLKI----------FPNKTLEKL 232

Query: 235 KNLAFMESDILEKVKE-HQESMDINNPRDFIDCFL-IKMEKEKQN----QQSEFTIENLV 288
           K+   + +D+L K+ E ++E    ++  + +D  +  KM  +  N    Q SE   +N +
Sbjct: 233 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 292

Query: 289 ITA-ADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPY 347
           +T   D+ GAG ETT++ +++ L  LL +P+V  K+ EEI++ +G +R+P + DR  +  
Sbjct: 293 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 352

Query: 348 TDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMF 407
            +A + EV R   + P  +PH    D     + + KGT ++ +L ++ H+ KE+  P+ F
Sbjct: 353 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412

Query: 408 DPRHFLDEGGN--FKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459
            P  FL+  G      S  ++PF AG R C+GE LAR ELFL + ++LQ F+L+
Sbjct: 413 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  196 bits (498), Expect = 4e-50
 Identities = 134/460 (29%), Positives = 224/460 (48%), Gaps = 20/460 (4%)

Query: 28  KLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 87
           K PP P   P++G++L +  K+   +L+ +S+ YG V  +  G   ++VL   + +++AL
Sbjct: 40  KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 98

Query: 88  IDLGEEFSGRGHFPLAERANRGFGIVFS--NGKRWKEIRRFSLMTLRNFGMGKRS----- 140
           +  G++F GR     +     G  + FS  +G  W   RR +   L  F +         
Sbjct: 99  VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 158

Query: 141 --IEDRVQEEARCLVEELRKTKASP--CDPTFILGCAPCNVICSIIFQKRFDYKDQQFLN 196
             +E+ V +EA+ L+  L++  A P   DP   +  +  NVI ++ F + F     + L+
Sbjct: 159 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 218

Query: 197 LMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEK-VKEHQESM 255
           L++  +E +   S+      + FP I+ Y P    +  K         L+K V+EH +  
Sbjct: 219 LVKNTHEFVETASSG--NPLDFFP-ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 275

Query: 256 DINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLK 315
           D N+ RD         +K  +   +    E +V    D+ GAG +T +T + ++L+ L+ 
Sbjct: 276 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 335

Query: 316 HPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVK 375
            PE+  K+Q+E++ VIGR R P + DR  +PY +A + E  R+   +P ++PH+ T D  
Sbjct: 336 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 395

Query: 376 FRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG---NFKKSNYFMPFSAGK 432
              + IPK   +  +   V HD + + +P  F P  FL   G   N   S   M F  GK
Sbjct: 396 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 455

Query: 433 RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPV 472
           R C+GE LA+ E+FLFL  +LQ     S+     +D TP+
Sbjct: 456 RRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 494


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  171 bits (434), Expect = 1e-42
 Identities = 127/434 (29%), Positives = 214/434 (49%), Gaps = 25/434 (5%)

Query: 37  PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSG 96
           P+    L +   D+   L  L++ +GP++ L+ GL+ +VVL+    ++EA++    +F+G
Sbjct: 32  PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAG 91

Query: 97  RGHFPLAERANRGF-----GIVFSNGKRWKEIRRFSLMTLRNFGMGKR-SIEDRVQEEAR 150
           R      +  +R +     G      K  K++ R +L+      +G R S+E  V++  +
Sbjct: 92  RPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL------LGIRDSMEPVVEQLTQ 145

Query: 151 CLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVST 210
              E +R    +P           C++IC + F  +   KD   +    K  + +    +
Sbjct: 146 EFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWS 203

Query: 211 PW-IQICNNFPTIIDYFPGTHNKLLKNLAFMESDILE-KVKEHQESMDINNPRDFIDCFL 268
            W IQI +  P  + +FP    + LK        I+E ++++H+ES+     RD +D  L
Sbjct: 204 HWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYML 262

Query: 269 IKMEKEKQNQQSEFTIENLV-ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEI 327
             + +    + S   +E  V + A DLL  GTETT+ TL +A++ LL HPE+  ++QEE+
Sbjct: 263 QGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEEL 322

Query: 328 ERVIGRNRSPCM---QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKG 384
           +  +G   S      +DR  +P  +A + EV R   ++P +LPH  T       Y IP+G
Sbjct: 323 DHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEG 382

Query: 385 TTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARME 444
           T I+ +L     D   +  P  F P  FL+ G    K++  + F  G R+C+GE LAR+E
Sbjct: 383 TVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLE 438

Query: 445 LFLFLTFILQNFNL 458
           LF+ LT +LQ F L
Sbjct: 439 LFVVLTRLLQAFTL 452


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  154 bits (388), Expect = 2e-37
 Identities = 122/428 (28%), Positives = 201/428 (46%), Gaps = 43/428 (10%)

Query: 37  PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSG 96
           P+    L +   D+   L  L++ +GP++ L+ GL+  +V   Y        DL      
Sbjct: 32  PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDKLVSRNYP-------DLS----- 79

Query: 97  RGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEEL 156
            G + L  +A++            K  R   L+ +R+      S+E  V++  +   E +
Sbjct: 80  LGDYSLLWKAHK------------KLTRSALLLGIRD------SMEPVVEQLTQEFCERM 121

Query: 157 RKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPW-IQI 215
           R    +P           C++IC + F  +   KD   +    K  + +    + W IQI
Sbjct: 122 RAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQI 179

Query: 216 CNNFPTIIDYFPGTHNKLLKNLAFMESDILE-KVKEHQESMDINNPRDFIDCFLIKMEKE 274
            +  P  + +FP    + LK        I+E ++++H+ES+     RD +D  L  + + 
Sbjct: 180 VDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQP 238

Query: 275 KQNQQSEFTIENLV-ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGR 333
              + S   +E  V + A DLL  GTETT+ TL +A++ LL HPE+  ++QEE++  +G 
Sbjct: 239 SMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGP 298

Query: 334 NRSPCM---QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTS 390
             S      +DR  +P  +A + EV R   ++P +LPH  T       Y IP+GT I+ +
Sbjct: 299 GASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPN 358

Query: 391 LTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT 450
           L     D   +  P  F P  FL+ G    K++  + F  G R+C+GE LAR+ELF+ LT
Sbjct: 359 LQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLT 414

Query: 451 FILQNFNL 458
            +LQ F L
Sbjct: 415 RLLQAFTL 422


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  127 bits (319), Expect = 2e-29
 Identities = 125/483 (25%), Positives = 218/483 (45%), Gaps = 29/483 (6%)

Query: 8   VLCLSCLLLLSIWRQSSGR--GKLP-PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           VL  + L+LL I+   S +   KL  PGPTPLP +G IL   ++ +       ++ YG +
Sbjct: 13  VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEM 71

Query: 65  FTLYFGLERMVVLHGYEVVKEALI-DLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEI 123
           + LY G + M+V+   +++K  L+ +    F+ +   PL         + F+  + WK I
Sbjct: 72  WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQ--MPLGPMGFLKSALSFAEDEEWKRI 129

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARC---LVEELRKT--KASPCDPTFILGCAPCNVI 178
           R     TL +        ++ V   ++C   LV  LR+    +   +     G    +VI
Sbjct: 130 R-----TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

Query: 179 CSIIFQKRFDYKDQQ---FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLL- 234
              +F    D  +     FL  M+KL +   +   P++ + + FP +   F   +  L  
Sbjct: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFL--DPFLLLISLFPFLTPVFEALNIGLFP 242

Query: 235 KNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADL 294
           K++     + +E++KE +      +  DF    +     ++       +   LV  +  +
Sbjct: 243 KDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302

Query: 295 LGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR-GHMPYTDAVVH 353
           + A  +TTSTTL + +  L  HP+V  K+QEEI+ V+  N++P   D    M Y D VV+
Sbjct: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVN 361

Query: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413
           E  R   ++ + +      D++     IPKG  ++  + ++ HD K +  PE F P  F 
Sbjct: 362 ETLRLFPVV-SRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420

Query: 414 DEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID---PKDLDTT 470
            +  +      ++PF AG R C+G   A   + L +   LQNF+ K   +   P  LD  
Sbjct: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 480

Query: 471 PVV 473
           P++
Sbjct: 481 PIL 483


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  123 bits (309), Expect = 3e-28
 Identities = 125/484 (25%), Positives = 217/484 (44%), Gaps = 30/484 (6%)

Query: 8   VLCLSCLLLLSIWRQSSGR--GKLP-PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           VL  + L+LL I+   S +   KL  PGPTPLP +G IL   ++ +       ++ YG +
Sbjct: 13  VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEM 71

Query: 65  FTLYFGLERMVVLHGYEVVKEALI-DLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEI 123
           + LY G + M+V+   +++K  L+ +    F+ +   PL         + F+  + WK I
Sbjct: 72  WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQ--MPLGPMGFLKSALSFAEDEEWKRI 129

Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARC---LVEELRKT--KASPCDPTFILGCAPCNVI 178
           R     TL +        ++ V   ++C   LV  LR+    +   +     G    +VI
Sbjct: 130 R-----TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVI 184

Query: 179 CSIIFQKRFDYKDQQ---FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLL- 234
              +F    D  +     FL  M+KL +   +   P++ + + FP +   F   +  L  
Sbjct: 185 TGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFL--DPFLLLISLFPFLTPVFEALNIGLFP 242

Query: 235 KNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADL 294
           K++     + +E++KE +      +  DF    +     ++       +   LV  +  +
Sbjct: 243 KDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIII 302

Query: 295 LGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR-GHMPYTDAVVH 353
           + A  +TTSTTL + +  L  HP+V  K+QEEI+ V+  N++P   D    M Y D VV+
Sbjct: 303 IFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVN 361

Query: 354 EVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFL 413
           E  R   ++ + +      D++     IPKG  ++  + ++ HD K +  PE F P    
Sbjct: 362 ETLRLFPVV-SRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF 420

Query: 414 DEGGNFKKSNY-FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID---PKDLDT 469
            +        Y ++PF AG R C+G   A   + L +   LQNF+ K   +   P  LD 
Sbjct: 421 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 480

Query: 470 TPVV 473
            P++
Sbjct: 481 LPIL 484


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  122 bits (307), Expect = 6e-28
 Identities = 126/472 (26%), Positives = 197/472 (41%), Gaps = 37/472 (7%)

Query: 7   LVLCLSCLLLLSIWRQSSGRGKLP--PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           L+L +S +LL      S G  K    PGPTPLP +GNIL    K          K YG V
Sbjct: 13  LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKV 71

Query: 65  FTLYFGLERMVVLHGYEVVKEALI-DLGEEFSGRGHF-PLAERANRGFGIVFSNGKRWKE 122
           +  Y G + ++ +   +++K  L+ +    F+ R  F P+    +    I  +  + WK 
Sbjct: 72  WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKS---AISIAEDEEWKR 128

Query: 123 IRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKAS--PCDPTFILGCAPCNVIC 179
           +R     T   F  GK + +   + +    LV  LR+   +  P     + G    +VI 
Sbjct: 129 LRSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVIT 185

Query: 180 SIIFQKRFDYKDQQFLNLMEKLNENIRI-VSTPWIQICNNFPTIIDY--------FPG-T 229
           S  F    D  +      +E   + +R     P+      FP +I          FP   
Sbjct: 186 STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREV 245

Query: 230 HNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVI 289
            N L K++  M+   LE  ++H+         DF+   +     ++       +   LV 
Sbjct: 246 TNFLRKSVKRMKESRLEDTQKHRV--------DFLQLMIDSQNSKETESHKALSDLELVA 297

Query: 290 TAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTD 349
            +   + AG ETTS+ L + +  L  HP+V  K+QEEI+ V+     P       M Y D
Sbjct: 298 QSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLD 357

Query: 350 AVVHEVQRYIDLIPTSLPHAVTC--DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMF 407
            VV+E  R   L P ++     C  DV+     IPKG  ++    ++  D K +  PE F
Sbjct: 358 MVVNETLR---LFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414

Query: 408 DPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 459
            P  F  +  +      + PF +G R C+G   A M + L L  +LQNF+ K
Sbjct: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  119 bits (299), Expect = 5e-27
 Identities = 125/476 (26%), Positives = 200/476 (42%), Gaps = 23/476 (4%)

Query: 7   LVLCLSCLLLLSIWRQSSGRGKLP--PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64
           L+L +S +LL     ++ G  K    PGPTPLP++GN+L    + + K  T   K YG +
Sbjct: 13  LLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKM 71

Query: 65  FTLYFGLERMVVLHGYEVVKEALI-DLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEI 123
           +  Y G   ++ +   +V++  L+ +    F+ R    L         I  +  + WK I
Sbjct: 72  WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRS--LGPVGFMKSAISLAEDEEWKRI 129

Query: 124 RRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKT--KASPCDPTFILGCAPCNVICS 180
           R     T   F  GK + +   + +    LV  LR+   K  P     I G    +VI  
Sbjct: 130 RSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186

Query: 181 IIFQKRFDYKDQQFLNLMEKLNENIRI-VSTPWIQICNNFPTIIDYFPGTHNKLL-KNLA 238
             F    D  +      +E   + ++     P       FP +   F   +  L  K+  
Sbjct: 187 TSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTI 246

Query: 239 FMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAG 298
              S  + ++K+ + +    +  DF+   +     ++       +   L   +   + AG
Sbjct: 247 NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAG 306

Query: 299 TETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRY 358
            ETTS+ L + L  L  HP+V  K+Q+EI+ V+     P       M Y D VV+E  R 
Sbjct: 307 YETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR- 365

Query: 359 IDLIPTSLPHAVTC--DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEG 416
             L P ++    TC  DV+     IPKG+ ++    ++ HD K +  PE F P  F  + 
Sbjct: 366 --LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKK 423

Query: 417 GNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLID---PKDLDT 469
            +     Y  PF  G R C+G   A M + L L  +LQNF+ K   +   P  LDT
Sbjct: 424 DSIDPYIY-TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT 478


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  118 bits (295), Expect = 1e-26
 Identities = 115/456 (25%), Positives = 206/456 (45%), Gaps = 37/456 (8%)

Query: 29  LPPGPTPLPVIGNILQI--DIKDVSKSLTNLSKIYG--PVFTLYFGLERMVVLHGYEVVK 84
           +P      P++G+ L +  D ++  + +   ++ Y   P+  L+ G   MV L+  E V 
Sbjct: 50  IPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENV- 108

Query: 85  EALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDR 144
           E ++   ++      +   E    G G++ S G +W+  R+    T     +      D 
Sbjct: 109 EVILTSSKQIDKSSMYKFLEPW-LGLGLLTSTGNKWRSRRKMLTPTFHFTIL--EDFLDI 165

Query: 145 VQEEARCLVEELRK---TKASPCDPTFILGCAPCNVICSIIFQKRFDYK---DQQFLNLM 198
           + E+A  LV++L K    +A  C   F +     ++IC     K    +   D +++  +
Sbjct: 166 MNEQANILVKKLEKHINQEAFNC--FFYITLCALDIICETAMGKNIGAQSNDDSEYVRAV 223

Query: 199 EKLNENI-RIVSTPWIQICNNFPTIIDYFPGTHNKLLKNL-AFMESDILEKVKEHQESMD 256
            +++E I R +  PW+ +   +    + +   H K L+ L  F  S I E+  E   + D
Sbjct: 224 YRMSEMIFRRIKMPWLWLDLWYLMFKEGWE--HKKSLQILHTFTNSVIAERANEMNANED 281

Query: 257 I-----------NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTT 305
                       N  R F+D  L+ +  ++ N+ S   I   V T    +  G +TT+  
Sbjct: 282 CRGDGRGSAPSKNKRRAFLD-LLLSVTDDEGNRLSHEDIREEVDT---FMFEGHDTTAAA 337

Query: 306 LRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPT 364
           + ++L LL  +PEV  KV  E++ V G++  P  ++D   + Y + V+ E  R    +P 
Sbjct: 338 INWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL 397

Query: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424
               +V+ D +   Y + KGT  +    ++  D + FPNPE F P  F  E    +    
Sbjct: 398 -FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYA 456

Query: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKS 460
           ++PFSAG R C+G+  A ME    L+ IL++F ++S
Sbjct: 457 YVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIES 492


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.141    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,241,312
Number of Sequences: 37866
Number of extensions: 867264
Number of successful extensions: 2373
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2174
Number of HSP's gapped (non-prelim): 92
length of query: 490
length of database: 18,247,518
effective HSP length: 106
effective length of query: 384
effective length of database: 14,233,722
effective search space: 5465749248
effective search space used: 5465749248
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.