Search of human proteins with 4502833

Search of human proteins with 4502833

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
precursor [Homo sapiens]
         (502 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...  1030   0.0  
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     621   e-178
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   466   e-131
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   444   e-125
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    440   e-123
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   402   e-112
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   381   e-106
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   376   e-104
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   371   e-103
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   370   e-102
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...   369   e-102
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   362   e-100
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   328   7e-90
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   327   1e-89
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   308   1e-83
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   279   4e-75
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   275   5e-74
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              245   8e-65
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   213   2e-55
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   213   2e-55
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   199   4e-51
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              184   1e-46
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   158   1e-38
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   147   2e-35
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   145   1e-34
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...    84   3e-16
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s...    83   7e-16
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs...    83   7e-16
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr...    80   6e-15
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ...    79   1e-14

>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score = 1030 bits (2662), Expect = 0.0
 Identities = 502/502 (100%), Positives = 502/502 (100%)

Query: 1   MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL 60
           MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL
Sbjct: 1   MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL 60

Query: 61  MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLY 120
           MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLY
Sbjct: 61  MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLY 120

Query: 121 NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR 180
           NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR
Sbjct: 121 NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR 180

Query: 181 TEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTIN 240
           TEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTIN
Sbjct: 181 TEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTIN 240

Query: 241 LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY 300
           LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY
Sbjct: 241 LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY 300

Query: 301 LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR 360
           LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR
Sbjct: 301 LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR 360

Query: 361 LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC 420
           LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC
Sbjct: 361 LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC 420

Query: 421 GCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 480
           GCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ
Sbjct: 421 GCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 480

Query: 481 PLFQNYTTTTFLHSDHSAPSSK 502
           PLFQNYTTTTFLHSDHSAPSSK
Sbjct: 481 PLFQNYTTTTFLHSDHSAPSSK 502


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  621 bits (1601), Expect = e-178
 Identities = 315/486 (64%), Positives = 374/486 (76%), Gaps = 10/486 (2%)

Query: 11  LLGFGLLRLCS--GVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLI 68
           L+ F L+ LC        + EE+L++ LL+ +RYN LIRPAT+ S+L++++L +SLAQLI
Sbjct: 7   LVLFFLVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLI 66

Query: 69  SVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYE 128
           SV+EREQIMTTNVWL QEW DYRLTW    ++ +  +R+P+K IWLPD+VLYNNADG YE
Sbjct: 67  SVNEREQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYE 126

Query: 129 VSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLK 188
           VS Y+N +V  +GS+ WLPPAIYKSACKIEVK+FPFDQQNCT+KFRSWTYD TEID+VL 
Sbjct: 127 VSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLM 186

Query: 189 SEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLI 248
           +  AS+DDFTPSGEWDIVALPGRR  NP D +YVD+TYDFII+RKPLFYTINLIIPCVL 
Sbjct: 187 TPTASMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLT 246

Query: 249 TSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLV 308
           T LAILVFYLPSDCGEKMTLCISVLLALT FLLLISKIVPPTSLDVPL+GKYLMFTMVLV
Sbjct: 247 TLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLV 306

Query: 309 TFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR-LRLRRRQ 367
           TFSIVTSVCVLNVHHRSP+THTMAPWVK  FL KLP  LFM++P    +  R     +  
Sbjct: 307 TFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSC 366

Query: 368 REREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPG----RSGEPCGCG 423
             +  A A     +    +   FVN AS    A    A   PVA P     RS       
Sbjct: 367 VTKPEATATSTSPSNFYGNSMYFVNPASA---ASKSPAGSTPVAIPRDFWLRSSGRFRQD 423

Query: 424 LREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLF 483
           ++EA++GV FIA HM+++D+DQSV EDWKYVAMV+DRLFLW+F+FVCV GT+G+FL PLF
Sbjct: 424 VQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFLPPLF 483

Query: 484 QNYTTT 489
           Q +  +
Sbjct: 484 QTHAAS 489


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  466 bits (1199), Expect = e-131
 Identities = 244/470 (51%), Positives = 313/470 (66%), Gaps = 16/470 (3%)

Query: 26  TDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQ 85
           T+TE+RL +HL     YN+  RP  N S++V V+  +S+AQLI V E+ Q+MTTNVWL Q
Sbjct: 56  TETEDRLFKHLF--RGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQ 113

Query: 86  EWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFW 145
           EW DY+L W P +F N+  +R+PS+ IW+PD+VLYNNADG + V+  + A +   G++ W
Sbjct: 114 EWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHW 173

Query: 146 LPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDI 205
           +PPAIYKS+C I+V  FPFDQQNC MKF SWTYD+ +IDL    +   L D+  SGEW I
Sbjct: 174 VPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAI 233

Query: 206 VALPGRRNENPDD---STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC 262
           V   G  N    D     Y D+TY F+IRR PLFYTINLIIPC+LI+ L +LVFYLPSDC
Sbjct: 234 VNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDC 293

Query: 263 GEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVH 322
           GEK+TLCISVLL+LTVFLLLI++I+P TSL +PL+G+YL+FTM+ VT SIV +V VLNVH
Sbjct: 294 GEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVH 353

Query: 323 HRSPTTHTMAPWVKVVFLEKLPALLFMQQPR---HHCARQRLRLRRRQREREGAGALFFR 379
           HRSP+THTM  WV+   L  +P  L M +P      C   RL+L       E       R
Sbjct: 354 HRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEER 413

Query: 380 E--APGADSCTCFVNRASVQGLAGAFGAEPAPVAGPG-----RSGE-PCGCGLREAVDGV 431
           E      D   C  + A   G   + G   +  +GP      + GE      +++A++GV
Sbjct: 414 EVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGV 473

Query: 432 RFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQP 481
            +IADH+RSED D SV EDWKYVAMVIDR+FLW+F+ VC  GTIG+FL P
Sbjct: 474 HYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPP 523


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  444 bits (1142), Expect = e-125
 Identities = 232/498 (46%), Positives = 319/498 (64%), Gaps = 29/498 (5%)

Query: 7   PVAL----LLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMV 62
           P+AL    LL   LL L      ++ E RL E L +   YN++IRP  N S+ V +   V
Sbjct: 9   PLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFED--YNEIIRPVANVSDPVIIHFEV 66

Query: 63  SLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNN 122
           S++QL+ V E  QIM TN+WL Q W DY+L W P ++   + +R+P++ IW PD+VLYNN
Sbjct: 67  SMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNN 126

Query: 123 ADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTE 182
           A G ++V   + A++ Y G + W+PPAI+KS+CKI+V +FPFD QNCTMKF SW+YD+ +
Sbjct: 127 AVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAK 186

Query: 183 IDLVLKSEVASLDDFTPSGEWDIVALPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTI 239
           IDLVL     +L D+  SGEW I+  PG +++   N  +  Y DITY   IRR PLFYTI
Sbjct: 187 IDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTI 246

Query: 240 NLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGK 299
           NLIIPC+LI+ L +LVFYLPSDCGEK+TLCISVLL+LTVFLL+I++ +P TSL +PL+G+
Sbjct: 247 NLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGE 306

Query: 300 YLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQ 359
           YL+FTM+ VT SIV +V VLNVH+R+PTTHTM  WVK VFL  LP ++FM +P  +    
Sbjct: 307 YLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGN- 365

Query: 360 RLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAG------P 413
                ++ R   GA          A+S  C        G+ G        ++        
Sbjct: 366 ----AQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTR 421

Query: 414 GRSGEPCGCGL---------REAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLW 464
             S E     L         +EA+  V++IA++M+++++ + + +DWKYVAMVIDR+FLW
Sbjct: 422 SSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLW 481

Query: 465 IFVFVCVFGTIGMFLQPL 482
           +F  VC+ GT G+FLQPL
Sbjct: 482 VFTLVCILGTAGLFLQPL 499


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  440 bits (1131), Expect = e-123
 Identities = 223/467 (47%), Positives = 302/467 (64%), Gaps = 6/467 (1%)

Query: 22  GVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNV 81
           G  G  TEERL   L   S YN+ IRP  N S+ VTV   V++ QL +V E  QIM TN+
Sbjct: 27  GCVGCATEERLFHKLF--SHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNL 84

Query: 82  WLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDG 141
           WL   W DY+L W P E+D ++ +R+P+  IW PD+VLYNNA G ++V   + A++ Y+G
Sbjct: 85  WLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNG 144

Query: 142 SIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSG 201
            I W PPAI+KS+C +++  FPFD QNC++KF SWTYD+ EIDL++      ++DF  + 
Sbjct: 145 MITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENS 204

Query: 202 EWDIVALPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYL 258
           EW+I+   G +++   N  +  Y DITY F IRR P+FYTINLIIPC+ I+ L +LVFYL
Sbjct: 205 EWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYL 264

Query: 259 PSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCV 318
           PSDCGEK+TLCISVLL+LTVFLL+I++ +P TSL VPLVG+YL+FTM+ VT SIV +V V
Sbjct: 265 PSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFV 324

Query: 319 LNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFF 378
           LN+H+R+PTTHTM  WVK VFL+ LP +L M+ P             R   R  A     
Sbjct: 325 LNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLA 384

Query: 379 REAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHM 438
                     CF    S +           P+     + E     + + ++ V+FIA++M
Sbjct: 385 SHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEH-SPEVEDVINSVQFIAENM 443

Query: 439 RSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQN 485
           +S ++ + V +DWKYVAMV+DR+FLW+F+ VCVFGT G+FLQPL  N
Sbjct: 444 KSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLLGN 490


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  402 bits (1033), Expect = e-112
 Identities = 208/360 (57%), Positives = 263/360 (73%), Gaps = 11/360 (3%)

Query: 7   PVALLLGFGLLRLCSGV-WGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLA 65
           P+ LLLG GLLR  S V      EERL++ L   S YNK  RP  N S++V V+  +S+A
Sbjct: 14  PLLLLLGTGLLRASSHVETRAHAEERLLKKLF--SGYNKWSRPVANISDVVLVRFGLSIA 71

Query: 66  QLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADG 125
           QLI V E+ Q+MTTNVW+ QEW DY+L W P +++N+  +R+PS+ IW PD+VLYNNADG
Sbjct: 72  QLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADG 131

Query: 126 MYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDL 185
            + V+  + A + +DG + W PPAIYKS+C I+V  FPFDQQNCTMKF SWTYD+ +IDL
Sbjct: 132 DFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDL 191

Query: 186 V-LKSEVASLDDFTPSGEWDIVALPGRRNENPDD---STYVDITYDFIIRRKPLFYTINL 241
           V + S V  L DF  SGEW IV   G  N    +     Y DITY F+IRR PLFYTINL
Sbjct: 192 VNMHSRVDQL-DFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINL 250

Query: 242 IIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYL 301
           IIPC+LI+ L +LVFYLPS+CGEK+TLCISVLL+LTVFLLLI++I+P TSL +PL+G+YL
Sbjct: 251 IIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYL 310

Query: 302 MFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQP---RHHCAR 358
           +FTM+ VT SIV +V VLNVHHRSP THTM  WV+ VFL+ +P LL M++P   + +C R
Sbjct: 311 LFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRR 370



 Score = 93.2 bits (230), Expect = 5e-19
 Identities = 53/125 (42%), Positives = 71/125 (56%), Gaps = 14/125 (11%)

Query: 367 QREREGAGALFFREAPGAD----------SCTCFVNRASVQGLAGAFGAEPAPVAGPGRS 416
           + + + AGAL  R    A+           CTC    +SV   A       +  A P   
Sbjct: 501 EADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATV--KTRSTKAPPPHL 558

Query: 417 GEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIG 476
             P    L  AV+GV++IADH+++ED D SV EDWKYVAMVIDR+FLW+F+ VC+ GT+G
Sbjct: 559 --PLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVG 616

Query: 477 MFLQP 481
           +FL P
Sbjct: 617 LFLPP 621


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  381 bits (978), Expect = e-106
 Identities = 211/496 (42%), Positives = 293/496 (59%), Gaps = 22/496 (4%)

Query: 6   GPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLA 65
           GPV  L     L +C G WG + EERL+ HL     YNK +RP  +  E V V L ++L+
Sbjct: 3   GPVLTLGLLAALAVC-GSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLS 61

Query: 66  QLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADG 125
            LIS+ E E+ +TTNVW+   W D RL W  EEF N+  +RLP   +WLP++VL NN DG
Sbjct: 62  NLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDG 121

Query: 126 MYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDL 185
            +++S+  N +V + G ++WLPPAI++S+C I V +FPFD QNC++KF S  Y   EI L
Sbjct: 122 SFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITL 181

Query: 186 VLKSE------------VASLDDFTPSGEWDIVALPGRRNENP----DDSTYVDITYDFI 229
            LK +            +   + FT +GEW+IV  P R N +P    D  +  DIT+  I
Sbjct: 182 SLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLI 241

Query: 230 IRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPP 289
           IRRKPLFY IN+++PCVLI+ +  LVFYLP+D GEK ++ ISVLLA +VFLLLISK +P 
Sbjct: 242 IRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPA 301

Query: 290 TSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFM 349
           TS+ +PL+GK+L+F MVLVT  +V  V VLN+H R+P+TH ++  VK +FLE LP LL M
Sbjct: 302 TSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLHM 361

Query: 350 QQPRHHCARQRLRLRRRQR--EREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEP 407
            +P          +RR         A   F  +   + S   F  ++   GLA       
Sbjct: 362 SRPAEDGPSPGALVRRSSSLGYISKAEEYFLLK---SRSDLMFEKQSERHGLARRLTTAR 418

Query: 408 APVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFV 467
            P A   ++ +     L+ AVDG  FI +HMR +++     + W  VA  +DRL L++  
Sbjct: 419 RPPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVT 478

Query: 468 FVCVFGTIGMFLQPLF 483
            V V GT  +FLQ ++
Sbjct: 479 PVMVVGTAWIFLQGVY 494


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  376 bits (966), Expect = e-104
 Identities = 197/484 (40%), Positives = 296/484 (61%), Gaps = 40/484 (8%)

Query: 7   PVALLLGFGLLRLCSG--VWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSL 64
           P  LLL   L  LCS   V G++ E RLV  L     Y+ ++RP  +  ++V V + + L
Sbjct: 3   PWPLLL---LFSLCSAGLVLGSEHETRLVAKLFKD--YSSVVRPVEDHRQVVEVTVGLQL 57

Query: 65  AQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNAD 124
            QLI+V E  QI+TTNV L Q+W DY L W P+++  +KK+ +PS+ IW PD+VLYNNAD
Sbjct: 58  IQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD 117

Query: 125 GMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEID 184
           G + +  ++  ++ Y G I W PPAI+KS C+I V HFPFD+QNC+MK  +WTYD + + 
Sbjct: 118 GDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVA 177

Query: 185 LVLKSEVASLDDFTPSGEWDIVALPGRRNENP----DDSTYVDITYDFIIRRKPLFYTIN 240
           +  +S+   L +F  SGEW I    G ++        D+ Y+DITY F+++R PL++ +N
Sbjct: 178 INPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVN 237

Query: 241 LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY 300
           +IIPC+L + L  LVFYLP+D GEKMTL ISVLL+LTVFLL+I +++P TS  VPL+GKY
Sbjct: 238 VIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKY 297

Query: 301 LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR 360
           ++FTMV V  SI+ +V V+N HHRSP+TH M  WV+ VF++ +P ++F            
Sbjct: 298 MLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFS---------- 347

Query: 361 LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC 420
             ++R  RE++                  F     +  ++G  G  P     P       
Sbjct: 348 -TMKRPSREKQDK--------------KIFTEDIDISDISGKPGPPPMGFHSPLIKHPE- 391

Query: 421 GCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 480
              ++ A++G+++IA+ M+S+ +  + + +WKYVAMV+D + L +F+ VC+ GT+ +F  
Sbjct: 392 ---VKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAG 448

Query: 481 PLFQ 484
            L +
Sbjct: 449 RLIE 452


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  371 bits (952), Expect = e-103
 Identities = 190/479 (39%), Positives = 293/479 (61%), Gaps = 56/479 (11%)

Query: 27  DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQE 86
           + E+ L+ HL     Y K +RP  + ++ + V   + ++QL+ V E+ Q+MTTNVWL QE
Sbjct: 27  ENEDALLRHLFQG--YQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQE 84

Query: 87  WEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWL 146
           W D++L W P+++  +  +++PS+ +WLPD+VL+ NADG +E S  +  +V  +G++ W 
Sbjct: 85  WTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIVKSNGTVVWT 144

Query: 147 PPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIV 206
           PPA YKS+C ++V  FPFD+QNC+MKF SWTYD T +DL+L +E     DF  +GEW+I+
Sbjct: 145 PPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEIL 204

Query: 207 ALPGRRNENPDD-STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEK 265
              G +    D   +Y  ITY F++RR PLFYT+ LIIPC+ ++ L +LVFYLPSD GEK
Sbjct: 205 NAKGMKGNRRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEK 264

Query: 266 MTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRS 325
           ++L  SVL++LTVFLL+I +I+P +S  +PL+G+YL+F M+ VT SI+ +V V+NVHHRS
Sbjct: 265 LSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRS 324

Query: 326 PTT-HTMAPWVKVVFLEKLPALLFMQ-------QPRHHCARQRLRLRRRQREREGAGALF 377
            +T H MAPWVK +FL+KLP LL M+        P    ++  ++ +  +++++      
Sbjct: 325 SSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPVVKGKVLEKKKQK----- 379

Query: 378 FREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADH 437
            + + G      F+ +A+                                 D +R+I+ H
Sbjct: 380 -QLSDGEKVLVAFLEKAA---------------------------------DSIRYISRH 405

Query: 438 MRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDH 496
           ++ E     V +DWK+VA V+DR+FLW+F+ V V G++ +F   L        +LHS H
Sbjct: 406 VKKEHFISQVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFTPAL------KMWLHSYH 458


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  370 bits (949), Expect = e-102
 Identities = 184/458 (40%), Positives = 285/458 (62%), Gaps = 53/458 (11%)

Query: 29  EERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWE 88
           E+ L++ L     Y + +RP  + ++ + ++  ++++QL+ V E+ Q+MTTNVWL QEW 
Sbjct: 47  EDSLLKDLFQD--YERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWI 104

Query: 89  DYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPP 148
           D +L W P+++  +K +R+PS  +W PD+VL++NADG +E +  +  V+ Y+G++ W PP
Sbjct: 105 DVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTS-TKTVIRYNGTVTWTPP 163

Query: 149 AIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVAL 208
           A YKS+C I+V  FPFD QNC+MKF SWTYD +++D++L+ +     DF  +GEW+IV+ 
Sbjct: 164 ANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSA 223

Query: 209 PGRRNENPDDST-YVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMT 267
            G +    D    Y  +TY F+I+R PLFYT+ LIIPC+ ++ L +LVFYLPS+ GEK+ 
Sbjct: 224 TGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKIC 283

Query: 268 LCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT 327
           LC SVL++LTVFLL+I +I+P +S  +PL+G+YL+FTM+ VT SI+ +V  +N+HHRS +
Sbjct: 284 LCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSS 343

Query: 328 TH-TMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADS 386
           TH  MAP V+ +FL  LP LL        C R  +     Q+E   +G            
Sbjct: 344 THNAMAPLVRKIFLHTLPKLL--------CMRSHVDRYFTQKEETESG------------ 383

Query: 387 CTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQS 446
                                   +GP  S       L  A+D +R+I  H+  E+D + 
Sbjct: 384 ------------------------SGPKSSRNT----LEAALDSIRYITRHIMKENDVRE 415

Query: 447 VSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQ 484
           V EDWK++A V+DR+FLW F+FV + G++G+F+  +++
Sbjct: 416 VVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYK 453


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score =  369 bits (946), Expect = e-102
 Identities = 214/503 (42%), Positives = 297/503 (59%), Gaps = 39/503 (7%)

Query: 7   PVALLLGFGLLR--LCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSL 64
           P ALL+  G L   L  GV G++ E RL E L   S Y+  +RPA    + V V + + L
Sbjct: 3   PGALLMLLGALGAPLAPGVRGSEAEGRLREKLF--SGYDSSVRPAREVGDRVRVSVGLIL 60

Query: 65  AQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNAD 124
           AQLIS++E+++ M+T V+L  EW DYRL+W P E D +  +R+ ++ +WLPDVVL NN D
Sbjct: 61  AQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNND 120

Query: 125 GMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEID 184
           G ++V+   + VVS DGS+ W PP IY+S+C I+V +FPFD QNCTM F S++YD +E+ 
Sbjct: 121 GNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS 180

Query: 185 LVL--------KSEVASLDD-FTPSGEWDIVALPGRRNENPDD------STYVDITYDFI 229
           L            E+   +  F  +G+W+I+  P R  + P D          ++ +  I
Sbjct: 181 LQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLI 240

Query: 230 IRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPP 289
           IRRKPLFY +N+I PC+LIT LAI VFYLP D GEKM L I  LL LTVFLLL++  VP 
Sbjct: 241 IRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPE 300

Query: 290 TSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFM 349
           TSL VP++ KYLMFTMVLVTFS++ SV VLN+HHRSP TH M  WV+ +F+ KLP  L +
Sbjct: 301 TSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRL 360

Query: 350 QQPR---------HHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLA 400
           ++P+          HC+       R   E       +F   P +D      NR   +  A
Sbjct: 361 KRPKPERDLMPEPPHCSSPGSGWGRGTDE-------YFIRKPPSDFLFPKPNRFQPELSA 413

Query: 401 GAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDR 460
                    + GP R+       LRE V  + +IA  ++ ++D  ++ EDW++VAMV+DR
Sbjct: 414 PDLRRF---IDGPNRAVALLP-ELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDR 469

Query: 461 LFLWIFVFVCVFGTIGMFLQPLF 483
           LFLW F+     GT+ +FL   +
Sbjct: 470 LFLWTFIIFTSVGTLVIFLDATY 492


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  362 bits (930), Expect = e-100
 Identities = 197/509 (38%), Positives = 296/509 (58%), Gaps = 65/509 (12%)

Query: 7   PVALLLGFGLLRLCSG--VWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSL 64
           P  LLL   L  LCS   V G++ E RLV  L     Y+ ++RP  +  ++V V + + L
Sbjct: 3   PWPLLL---LFSLCSAGLVLGSEHETRLVAKLFKD--YSSVVRPVEDHRQVVEVTVGLQL 57

Query: 65  AQLISVHEREQIMTTNVWLTQ-------------------------EWEDYRLTWKPEEF 99
            QLI+V E  QI+TTNV L Q                         +W DY L W P+++
Sbjct: 58  IQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDY 117

Query: 100 DNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEV 159
             +KK+ +PS+ IW PD+VLYNNADG + +  ++  ++ Y G I W PPAI+KS C+I V
Sbjct: 118 GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIV 177

Query: 160 KHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENP--- 216
            HFPFD+QNC+MK  +WTYD + + +  +S+   L +F  SGEW I    G ++      
Sbjct: 178 THFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSC 237

Query: 217 -DDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLA 275
             D+ Y+DITY F+++R PL++ +N+IIPC+L + L  LVFYLP+D GEKMTL ISVLL+
Sbjct: 238 CPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLS 297

Query: 276 LTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWV 335
           LTVFLL+I +++P TS  VPL+GKY++FTMV V  SI+ +V V+N HHRSP+TH M  WV
Sbjct: 298 LTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWV 357

Query: 336 KVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRAS 395
           + VF++ +P ++F              ++R  RE++                  F     
Sbjct: 358 RKVFIDTIPNIMFFS-----------TMKRPSREKQDK--------------KIFTEDID 392

Query: 396 VQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVA 455
           +  ++G  G  P     P          ++ A++G+++IA+ M+S+ +  + + +WKYVA
Sbjct: 393 ISDISGKPGPPPMGFHSPLIKHPE----VKSAIEGIKYIAETMKSDQESNNAAAEWKYVA 448

Query: 456 MVIDRLFLWIFVFVCVFGTIGMFLQPLFQ 484
           MV+D + L +F+ VC+ GT+ +F   L +
Sbjct: 449 MVMDHILLGVFMLVCIIGTLAVFAGRLIE 477


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  328 bits (841), Expect = 7e-90
 Identities = 175/495 (35%), Positives = 279/495 (56%), Gaps = 27/495 (5%)

Query: 4   RCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVS 63
           RC P  + L      L   + G + + +L + L+    YN L RP  N S+ +TV   +S
Sbjct: 2   RCSPGGVWLALAASLLHVSLQG-EFQRKLYKELV--KNYNPLERPVANDSQPLTVYFSLS 58

Query: 64  LAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNA 123
           L Q++ V E+ Q++TTN+WL   W D+ L W   E+  +K VR P   IW PD++LYN+A
Sbjct: 59  LLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSA 118

Query: 124 DGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEI 183
           D  ++ +F++N +V+  G   +LPP I+KS+C I+V+ FPFD Q+C +KF SW+Y    +
Sbjct: 119 DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 178

Query: 184 DLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDD---STYVDITYDFIIRRKPLFYTIN 240
           DL ++   A +  + P+GEWD+V +PG+R+E   +     Y D+T+   +RR+ L+Y +N
Sbjct: 179 DLQMQE--ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLN 236

Query: 241 LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY 300
           L+IPCVLI++LA+LVF LP+D GEK++L I+VLL+LTVF+LL+++I+P TS  VPL+ +Y
Sbjct: 237 LLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQY 296

Query: 301 LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQR 360
              TM++V  S+V +V VL  HH  P    M  W +V+ L      L M++P     R  
Sbjct: 297 FASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPA 356

Query: 361 LRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQG-----------LAGAFGAEPAP 409
            + ++R+              P ++    ++    + G           + G     P  
Sbjct: 357 CQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTH 416

Query: 410 -----VAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLW 464
                  G    G+P    L + ++ VR+IA+  R +D+ ++V  +WK+ A V+DRL L 
Sbjct: 417 DEHLLHGGQPPEGDP---DLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLM 473

Query: 465 IFVFVCVFGTIGMFL 479
            F    +  TIG+ +
Sbjct: 474 AFSVFTIICTIGILM 488


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  327 bits (839), Expect = 1e-89
 Identities = 198/511 (38%), Positives = 286/511 (55%), Gaps = 36/511 (7%)

Query: 6   GPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLA 65
           GP+ LLL   LL +C G  G + EERL+  L+    Y+  +RPA   S++V V L ++L 
Sbjct: 6   GPLLLLL---LLAVCLGAQGRNQEERLLADLMQ--NYDPNLRPAERDSDVVNVSLKLTLT 60

Query: 66  QLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADG 125
            LIS++ERE+ +TTNVW+  +W DYRL W P +++ +  +R+PS  +W PD+VL NN DG
Sbjct: 61  NLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDG 120

Query: 126 MYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDL 185
           ++EV+ Y N +VS DG I+WLPPAI++SAC I V +FPFD QNC++ F+S TY   EIDL
Sbjct: 121 VFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDL 180

Query: 186 VLKSEVASL--------DDFTPSGEWDIVALPGRRNENP----DDSTYVDITYDFIIRRK 233
            L  E            + FT +GEW I   P +   +P     ++ +  + +  +I+RK
Sbjct: 181 QLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRK 240

Query: 234 PLFYTINLIIPCVLITSLAILVFYLPSDC-GEKMTLCISVLLALTVFLLLISKIVPPTSL 292
           PLFY IN+I PCVLI+S+AIL+ +LP+   G+K T+ I+VLLA TVFL L++K VP TS 
Sbjct: 241 PLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQ 300

Query: 293 DVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQ-Q 351
            VPL+ KYL F +V+    +V +V VLNV  RSP TH+MA  V+ VFL  LP LL M  +
Sbjct: 301 AVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVR 360

Query: 352 PRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASV------QGLAGAF-- 403
           P    A Q  + R +       G+  +    G +   C      +      QGL  A   
Sbjct: 361 PLAPAAVQDTQSRLQN------GSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALE 414

Query: 404 GAEPAPVAGPGR---SGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDR 460
             E  P  G  +   S +     ++  V+    IA     +    + +E+W  V  V+DR
Sbjct: 415 KLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDR 474

Query: 461 LFLWIFVFVCVFGTIGMFLQPLFQNYTTTTF 491
           +     + + + GT G+FL   +       F
Sbjct: 475 VCFLAMLSLFICGTAGIFLMAHYNRVPALPF 505


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  308 bits (788), Expect = 1e-83
 Identities = 189/500 (37%), Positives = 277/500 (55%), Gaps = 38/500 (7%)

Query: 1   MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL 60
           MAR   P+ +LL  GLL    GV G + E RL  HL +   Y+   RP     + VT+ L
Sbjct: 1   MAR--APLGVLLLLGLLG--RGV-GKNEELRLYHHLFN--NYDPGSRPVREPEDTVTISL 53

Query: 61  MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLY 120
            V+L  LIS++E+E+ +TT+VW+  +W+DYRL +  ++F  ++ +R+PS+ +WLP++VL 
Sbjct: 54  KVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLE 113

Query: 121 NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR 180
           NN DG + V++ +N +V   GS+ WLPPAIY+S C +EV +FPFD QNC++ FRS TY+ 
Sbjct: 114 NNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNA 173

Query: 181 TEIDLVLKSE-----VASLD----DFTPSGEWDIVALPG--RRNEN--PDDSTYVDITYD 227
            E++     +     +  +D     +T +GEW I   PG  RR+     D     D+ Y 
Sbjct: 174 EEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYS 233

Query: 228 FIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC-GEKMTLCISVLLALTVFLLLISKI 286
            IIRRKPLFY IN+I+PCVLI+ L +L ++LP+   G+K T+ I+VLLA TVFL LI++ 
Sbjct: 234 LIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQK 293

Query: 287 VPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPAL 346
           +P TSL VPL+G++L+F MV+ T  ++  V VLNV  R+PTTH M+P ++ V LE LP L
Sbjct: 294 IPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRL 353

Query: 347 LFMQQPRHHCARQRLRLRRRQREREGAGALFFRE---APGADSCTCFVNRASVQGLAGAF 403
           L    P      +  R     R     G L   E        S   F  +   QG   A 
Sbjct: 354 LGSPPP-----PEAPRAASPPRRASSVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAA 408

Query: 404 GAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFL 463
             +    A P          +R  VD V F+A+  R ++       DW  +   +D +  
Sbjct: 409 FCQSLGAAAP---------EVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICF 459

Query: 464 WIFVFVCVFGTIGMFLQPLF 483
           W  + +   G+  +FL   F
Sbjct: 460 WAALVLFSVGSSLIFLGAYF 479


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  279 bits (714), Expect = 4e-75
 Identities = 171/479 (35%), Positives = 256/479 (53%), Gaps = 42/479 (8%)

Query: 8   VALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQL 67
           + LLL F L   C G  G     +L   L   + Y   +RP  +  + + V L V+L+Q+
Sbjct: 10  LGLLLLFLLPAECLGAEGR-LALKLFRDLF--ANYTSALRPVADTDQTLNVTLEVTLSQI 66

Query: 68  ISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMY 127
           I + ER Q++T  +W+ QEW D  L W P  +  +  +R+PS  +W PD+VLYN AD   
Sbjct: 67  IDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQP 126

Query: 128 EVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL 187
             S  +N V+ +DG++ W  PAI +S+C+++V  FPFD Q+C + F SWT+   ++D+  
Sbjct: 127 PGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRP 186

Query: 188 KSEVASLDDFTPSGEWDIVALPGRR---NENPDDSTYVDITYDFIIRRKPLFYTINLIIP 244
           +   ASL DF  + EW ++ +P RR           Y D+T+  ++RR+   Y  NL++P
Sbjct: 187 RGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLP 246

Query: 245 CVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFT 304
           CVLI+ LA L F+LP+D GEK++L ++VLLALTVF LL+++ +PP    VPL+GKY M T
Sbjct: 247 CVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAE-SVPLIGKYYMAT 305

Query: 305 MVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLR 364
           M +VTFS   ++ ++N+H+  P+   +  W +        ALL     R  C R+R    
Sbjct: 306 MTMVTFSTALTILIMNLHYCGPSVRPVPAWAR--------ALLLGHLARGLCVRERGEPC 357

Query: 365 RRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEP-CGCG 423
            + R  E         +P            S +G AG       P AGP    EP C C 
Sbjct: 358 GQSRPPE------LSPSP-----------QSPEGGAG-------PPAGP--CHEPRCLCR 391

Query: 424 LREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPL 482
               +  V  IA+  RS    Q   EDWK +A V+DR FL IF  + +  ++ + +Q L
Sbjct: 392 QEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL 450


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  275 bits (704), Expect = 5e-74
 Identities = 148/441 (33%), Positives = 236/441 (53%), Gaps = 24/441 (5%)

Query: 42  YNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDN 101
           Y+  +RP  +  +++ V L ++L+Q+  + ER QI+T  +W+ Q W D  LTW  +++D 
Sbjct: 42  YSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDG 101

Query: 102 MKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKH 161
           +  +R+PS  +W PD+VLYN AD        +N V+ YDG I W  PAI KS+C ++V +
Sbjct: 102 LDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTY 161

Query: 162 FPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRN---ENPDD 218
           FPFD Q C + F SWTY+  ++D+    +   L DF    EW++  +P  +N        
Sbjct: 162 FPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCS 221

Query: 219 STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTV 278
             Y D+T+  +++R+  FY +NL+IPCVLI+ LA L FYLP+  GEK++L +++LLA+TV
Sbjct: 222 EPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTV 281

Query: 279 FLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVV 338
           F L++++I+ P S +VPL+GKY + TM L+T S   ++ V+N+H        +  W +VV
Sbjct: 282 FQLMVAEIM-PASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVV 340

Query: 339 FLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALF-------FREAPGADSCTCFV 391
            L+ +  +LF+      C           RER+    ++        + A   D      
Sbjct: 341 ILKYMSRVLFVYDVGESCLSP-----HHSRERDHLTKVYSKLPESNLKAARNKDLSRKKD 395

Query: 392 NRASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDW 451
               ++   G  G  P       +  E      +     + +IA  ++      S   +W
Sbjct: 396 MNKRLKNDLGCQGKNP-------QEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEW 448

Query: 452 KYVAMVIDRLFLWIFVFVCVF 472
           K VA VIDR F+WIF F+ VF
Sbjct: 449 KKVAKVIDRFFMWIF-FIMVF 468


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  245 bits (625), Expect = 8e-65
 Identities = 133/389 (34%), Positives = 219/389 (56%), Gaps = 26/389 (6%)

Query: 110 KHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNC 169
           +H+W+      + AD  ++ +F++N +V+  G   +LPP I+KS+C I+V+ FPFD Q+C
Sbjct: 17  QHLWI--AANCDIADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHC 74

Query: 170 TMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDD---STYVDITY 226
            +KF SW+Y    +DL ++   A +  + P+GEWD+V +PG+R+E   +     Y D+T+
Sbjct: 75  KLKFGSWSYGGWSLDLQMQE--ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTF 132

Query: 227 DFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKI 286
              +RR+ L+Y +NL+IPCVLI++LA+LVF LP+D GEK++L I+VLL+LTVF+LL+++I
Sbjct: 133 TVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEI 192

Query: 287 VPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPAL 346
           +P TS  VPL+ +Y   TM++V  S+V +V VL  HH  P    M  W +V+ L      
Sbjct: 193 MPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWF 252

Query: 347 LFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQG-------- 398
           L M++P     R   + ++R+              P ++    ++    + G        
Sbjct: 253 LRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPD 312

Query: 399 ---LAGAFGAEPAP-----VAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSED 450
              + G     P         G    G+P    L + ++ VR+IA+  R +D+ ++V  +
Sbjct: 313 SGVVCGRMACSPTHDEHLLHGGQPPEGDP---DLAKILEEVRYIANRFRCQDESEAVCSE 369

Query: 451 WKYVAMVIDRLFLWIFVFVCVFGTIGMFL 479
           WK+ A V+DRL L  F    +  TIG+ +
Sbjct: 370 WKFAACVVDRLCLMAFSVFTIICTIGILM 398


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  213 bits (543), Expect = 2e-55
 Identities = 124/458 (27%), Positives = 233/458 (50%), Gaps = 32/458 (6%)

Query: 31  RLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDY 90
           RL ++LL  + Y K +RP  +  +  TV + V +  +++V E+ Q++TT +W  Q W D 
Sbjct: 42  RLSDYLL--TNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDE 99

Query: 91  RLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAI 150
            L W PE+FDN+ K+ +P+  IW+PD+++    D + +        + + G +    P  
Sbjct: 100 FLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD-VGKSPNIPYVYIRHQGEVQNYKPLQ 158

Query: 151 YKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL----KSEVASLDDFTPSGEWDIV 206
             +AC +++ +FPFD QNC++ F SW +   +I++ L    +   +    F   GEW+++
Sbjct: 159 VVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELL 218

Query: 207 A-LPGRRNENPDDSTY-VDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGE 264
             LP  R  + + S Y  ++ +  +IRR+PLFY ++L++P + +  + I+ FYLP + GE
Sbjct: 219 GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 278

Query: 265 KMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHR 324
           +++  I++LL  +VFL+++S  +P T++  PL+G Y +  M L+  S+  ++ ++ + H+
Sbjct: 279 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHK 338

Query: 325 SPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGA 384
                 +  W++ + LE++  LL        C R++   +R              +A   
Sbjct: 339 QDLQQPVPAWLRHLVLERIAWLL--------CLREQSTSQRPPAT---------SQATKT 381

Query: 385 DSCTCFVNRASVQGLAGAFGAEPAPVAG---PGRSGEPCGCGLREAVDGVRFIADHMRSE 441
           D C+   N  S  G    F   P        P R      CGL + +  +R     +   
Sbjct: 382 DDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIR---QFLEKR 438

Query: 442 DDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL 479
           D+ + V+ DW  V  V+D+L   I++   +  +I + +
Sbjct: 439 DEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 476


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  213 bits (543), Expect = 2e-55
 Identities = 124/458 (27%), Positives = 233/458 (50%), Gaps = 32/458 (6%)

Query: 31  RLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDY 90
           RL ++LL  + Y K +RP  +  +  TV + V +  +++V E+ Q++TT +W  Q W D 
Sbjct: 21  RLSDYLL--TNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDE 78

Query: 91  RLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAI 150
            L W PE+FDN+ K+ +P+  IW+PD+++    D + +        + + G +    P  
Sbjct: 79  FLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD-VGKSPNIPYVYIRHQGEVQNYKPLQ 137

Query: 151 YKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL----KSEVASLDDFTPSGEWDIV 206
             +AC +++ +FPFD QNC++ F SW +   +I++ L    +   +    F   GEW+++
Sbjct: 138 VVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELL 197

Query: 207 A-LPGRRNENPDDSTY-VDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGE 264
             LP  R  + + S Y  ++ +  +IRR+PLFY ++L++P + +  + I+ FYLP + GE
Sbjct: 198 GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 257

Query: 265 KMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHR 324
           +++  I++LL  +VFL+++S  +P T++  PL+G Y +  M L+  S+  ++ ++ + H+
Sbjct: 258 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHK 317

Query: 325 SPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGA 384
                 +  W++ + LE++  LL        C R++   +R              +A   
Sbjct: 318 QDLQQPVPAWLRHLVLERIAWLL--------CLREQSTSQRPPAT---------SQATKT 360

Query: 385 DSCTCFVNRASVQGLAGAFGAEPAPVAG---PGRSGEPCGCGLREAVDGVRFIADHMRSE 441
           D C+   N  S  G    F   P        P R      CGL + +  +R     +   
Sbjct: 361 DDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIR---QFLEKR 417

Query: 442 DDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL 479
           D+ + V+ DW  V  V+D+L   I++   +  +I + +
Sbjct: 418 DEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVM 455


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  199 bits (507), Expect = 4e-51
 Identities = 125/490 (25%), Positives = 234/490 (47%), Gaps = 64/490 (13%)

Query: 31  RLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDY 90
           RL ++LL  + Y K +RP  +  +  TV + V +  +++V E+ Q++TT +W  Q W D 
Sbjct: 42  RLSDYLL--TNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDE 99

Query: 91  RLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAI 150
            L W PE+FDN+ K+ +P+  IW+PD+++    D + +        + + G +    P  
Sbjct: 100 FLQWNPEDFDNITKLSIPTDSIWVPDILINEFVD-VGKSPNIPYVYIRHQGEVQNYKPLQ 158

Query: 151 YKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL----KSEVASLDDFTPSGEWDIV 206
             +AC +++ +FPFD QNC++ F SW +   +I++ L    +   +    F   GEW+++
Sbjct: 159 VVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELL 218

Query: 207 A-LPGRRNENPDDSTY-VDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGE 264
             LP  R  + + S Y  ++ +  +IRR+PLFY ++L++P + +  + I+ FYLP + GE
Sbjct: 219 GVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGE 278

Query: 265 KMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGK------------------------- 299
           +++  I++LL  +VFL+++S  +P T++  PL+GK                         
Sbjct: 279 RVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHLLHVSLAS 338

Query: 300 -------YLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQP 352
                  Y +  M L+  S+  ++ ++ + H+      +  W++ + LE++  LL     
Sbjct: 339 ALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLL----- 393

Query: 353 RHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAG 412
              C R++   +R              +A   D C+   N  S  G    F   P     
Sbjct: 394 ---CLREQSTSQRPPAT---------SQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCS 441

Query: 413 ---PGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFV 469
              P R      CGL + +  +R     +   D+ + V+ DW  V  V+D+L   I++  
Sbjct: 442 PPPPPREASLAVCGLLQELSSIR---QFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLA 498

Query: 470 CVFGTIGMFL 479
            +  +I + +
Sbjct: 499 VLAYSITLVM 508


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  184 bits (468), Expect = 1e-46
 Identities = 103/307 (33%), Positives = 167/307 (54%), Gaps = 22/307 (7%)

Query: 192 ASLDDFTPSGEWDIVALPGRRNENPDD---STYVDITYDFIIRRKPLFYTINLIIPCVLI 248
           A +  + P+GEWD+V +PG+R+E   +     Y D+T+   +RR+ L+Y +NL+IPCVLI
Sbjct: 4   ADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLI 63

Query: 249 TSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLV 308
           ++LA+LVF LP+D GEK++L I+VLL+LTVF+LL+++I+P TS  VPL+ +Y   TM++V
Sbjct: 64  SALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIV 123

Query: 309 TFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQR 368
             S+V +V VL  HH  P    M  W +V+ L      L M++P     R   + ++R+ 
Sbjct: 124 GLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRC 183

Query: 369 EREGAGALFFREAPGADSCTCFVNRASVQG-----------LAGAFGAEPAP-----VAG 412
                        P ++    ++    + G           + G     P         G
Sbjct: 184 SLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGG 243

Query: 413 PGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVF 472
               G+P    L + ++ VR+IA+  R +D+ ++V  +WK+ A V+DRL L  F    + 
Sbjct: 244 QPPEGDP---DLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTII 300

Query: 473 GTIGMFL 479
            TIG+ +
Sbjct: 301 CTIGILM 307


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  158 bits (399), Expect = 1e-38
 Identities = 92/319 (28%), Positives = 170/319 (53%), Gaps = 15/319 (4%)

Query: 34  EHLLDPSRYN-----KLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWE 88
           +H  DP+  N     K  RP TN S    V +  +++ ++ V+E+  ++++ +WL   W+
Sbjct: 52  QHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWD 111

Query: 89  DYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPP 148
           +  ++W PEE + + K+ + +K++WLPD+ +    D + +      A VS +G I +  P
Sbjct: 112 NPFISWNPEECEGITKMSMAAKNLWLPDIFIIELMD-VDKTPKGLTAYVSNEGRIRYKKP 170

Query: 149 AIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPS-----GEW 203
               S C +++ +FPFDQQNCT+ F S+ Y    + L ++ EV  + D + +     GEW
Sbjct: 171 MKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEW 230

Query: 204 DIVAL-PGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC 262
           +++ L       +   + Y  I +   IRR+P  Y INL++P   + ++  L FYLP   
Sbjct: 231 ELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKS 290

Query: 263 GEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVH 322
           G ++   I++LL   VFLL++S ++P +    PL+G Y    + L+  S++ ++ + ++ 
Sbjct: 291 GNRVPFKITLLLGYNVFLLMMSDLLPTSG--TPLIGVYFALCLSLMVGSLLETIFITHLL 348

Query: 323 HRSPTTHTMAP-WVKVVFL 340
           H + T     P W+  + L
Sbjct: 349 HVATTQPPPLPRWLHSLLL 367


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  147 bits (371), Expect = 2e-35
 Identities = 85/315 (26%), Positives = 154/315 (48%), Gaps = 11/315 (3%)

Query: 19  LCSGVWGTDT---EERLVEHLLDP--SRYNKLIRPATNGSELVTVQLMVSLAQLISVHER 73
           + +G+  TDT   ++  + HL      +Y+K +RP  N ++  TV L + +  ++ V   
Sbjct: 15  VAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAE 74

Query: 74  EQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYS 133
            QI+ T+VW  + W D  L+W    FD ++++ LP   IW PD+++    D +       
Sbjct: 75  NQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVD-IERYPDLP 133

Query: 134 NAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVAS 193
              V+  G+I    P    SAC +E   FPFD QNC++ F+S  +   ++DL        
Sbjct: 134 YVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPED 193

Query: 194 LDD----FTPSGEWDIVALPGRRN-ENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLI 248
           +      F    EW+++++    +        +  I ++ ++RR PL Y ++L+IP + +
Sbjct: 194 IQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFL 253

Query: 249 TSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLV 308
             + +  FYLP +C  ++    SVL+  TVF + +S  VP +    PL+G +    M  +
Sbjct: 254 MLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFL 313

Query: 309 TFSIVTSVCVLNVHH 323
             S+  S+ ++   H
Sbjct: 314 VLSLAKSIVLVKFLH 328


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  145 bits (365), Expect = 1e-34
 Identities = 86/319 (26%), Positives = 164/319 (51%), Gaps = 15/319 (4%)

Query: 34  EHLLDPSRYN-----KLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWE 88
           +H +DP+ +      K  RP TN S    V +  +L+ ++ V  + Q++T+ +W+   W+
Sbjct: 37  QHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWD 96

Query: 89  DYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPP 148
           +  + W P+E   + K+ + ++++WLPD+ +  + D + +      A +S +G I +  P
Sbjct: 97  NPFINWNPKECVGINKLTVLAENLWLPDIFIVESMD-VDQTPSGLTAYISSEGRIKYDKP 155

Query: 149 AIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDD-----FTPSGEW 203
               S C +++ +FPFDQQNCT  F S+ Y    + L +  EV  + D         GEW
Sbjct: 156 MRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEW 215

Query: 204 DIVAL-PGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC 262
           +++ +       +  ++ Y  I +   IRR+P  Y INL++P   + ++  L FYLP++ 
Sbjct: 216 ELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAES 275

Query: 263 GEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVH 322
             +    I++LL   VFLL+++ ++P +    PL+  Y    + L+  S++ +V +  + 
Sbjct: 276 ENRAPFKITLLLGYNVFLLMMNDLLPASG--TPLISVYFALCLSLMVVSLLETVFITYLL 333

Query: 323 HRSPTTHTMAP-WVKVVFL 340
           H + T     P W+  + L
Sbjct: 334 HVATTQPPPMPRWLHSLLL 352


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 64/275 (23%), Positives = 119/275 (43%), Gaps = 27/275 (9%)

Query: 42  YNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDN 101
           YNK +RP   G E V + L + +A + S+ E     T  ++L Q W D RL      F+ 
Sbjct: 48  YNKFLRP-NFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLV-----FEG 101

Query: 102 MKKVRLPSK---HIWLPDVVLYNNADG-MYEVSFYSNAVVSY-DGSIFWLPPAIYKSACK 156
            K   L ++    +W+PD  +  +    ++EV+  +  +  + +G++ +        AC 
Sbjct: 102 NKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACN 161

Query: 157 IEVKHFPFDQQNCTMKFRSWTYDRTEI--------DLVLKSEVASLDDFTPSGEWDIVAL 208
           +++  +P D Q C ++  SW YD  ++        D V   E   L  +T    + +V  
Sbjct: 162 MDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVT- 220

Query: 209 PGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTL 268
                   +   Y  +   F +RR  L++ +   +P   +  L+ + F++  D     T 
Sbjct: 221 ----RSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPART- 275

Query: 269 CISVLLALTVFLLLISK--IVPPTSLDVPLVGKYL 301
           CI V   L++  L+I     +P T+  +  +  YL
Sbjct: 276 CIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYL 310


>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
           sapiens]
          Length = 451

 Score = 82.8 bits (203), Expect = 7e-16
 Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 18/296 (6%)

Query: 31  RLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDY 90
           R+++ LLD   Y+  +RP   G  +  V   + +     V + +   T +V+  Q+W+D 
Sbjct: 44  RILDRLLDG--YDNRLRPGL-GDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDE 100

Query: 91  RLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAV--VSYDGSIFWLPP 148
           RL +K    + ++   L +  IW PD   +N    +       N +  +  DG++ +   
Sbjct: 101 RLKFKGP-MNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMR 159

Query: 149 AIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSG----EWD 204
              ++ C + ++ FP D  +C +KF S+ Y  +E+  +     +      P G    ++D
Sbjct: 160 LTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYD 219

Query: 205 IVALP-GRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCG 263
           ++    G+         Y  +T  F ++RK  ++ I   +PC++   L+ + F+L  +  
Sbjct: 220 LLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 279

Query: 264 EKMTLCISVLLALTVFLLLIS------KIVPPTSLDVPLVGKYLMFTMVLVTFSIV 313
              T+   V   LT+  L IS      K+   T++D  +   Y      L+ F+ V
Sbjct: 280 PARTV-FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATV 334


>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
           [Homo sapiens]
          Length = 451

 Score = 82.8 bits (203), Expect = 7e-16
 Identities = 66/296 (22%), Positives = 129/296 (43%), Gaps = 18/296 (6%)

Query: 31  RLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDY 90
           R+++ LLD   Y+  +RP   G  +  V   + +     V + +   T +V+  Q+W+D 
Sbjct: 44  RILDRLLDG--YDNRLRPGL-GDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDE 100

Query: 91  RLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAV--VSYDGSIFWLPP 148
           RL +K    + ++   L +  IW PD   +N    +       N +  +  DG++ +   
Sbjct: 101 RLKFKGP-MNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMR 159

Query: 149 AIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSG----EWD 204
              ++ C + ++ FP D  +C +KF S+ Y  +E+  +     +      P G    ++D
Sbjct: 160 LTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYD 219

Query: 205 IVALP-GRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCG 263
           ++    G+         Y  +T  F ++RK  ++ I   +PC++   L+ + F+L  +  
Sbjct: 220 LLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 279

Query: 264 EKMTLCISVLLALTVFLLLIS------KIVPPTSLDVPLVGKYLMFTMVLVTFSIV 313
              T+   V   LT+  L IS      K+   T++D  +   Y      L+ F+ V
Sbjct: 280 PARTV-FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATV 334


>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
           precursor [Homo sapiens]
          Length = 462

 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 68/296 (22%), Positives = 128/296 (43%), Gaps = 18/296 (6%)

Query: 31  RLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDY 90
           R+++ LLD   Y+  +RP   G  +  V+  + +     V + E   T +V+  Q W+D 
Sbjct: 51  RILDGLLDG--YDNRLRPGL-GERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDE 107

Query: 91  RLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSY--DGSIFWLPP 148
           RL +K      +    L +  IW PD   +N    +       N ++    DG++ +   
Sbjct: 108 RLRFKGP-MQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMR 166

Query: 149 AIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKS----EVASLDDFTPSGEWD 204
               + C ++++ FP D   C +KF S+ Y  +E+  V  +     V   +D +   ++ 
Sbjct: 167 LTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYH 226

Query: 205 IVA-LPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCG 263
           ++    G  N +     Y  +T  F ++RK  ++ I   +PC++   L+ + F+L  +  
Sbjct: 227 LMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 286

Query: 264 EKMTLCISVLLALTVFLLLIS------KIVPPTSLDVPLVGKYLMFTMVLVTFSIV 313
              T+   V   LT+  L IS      K+   T++D  +   Y      L+ F+ V
Sbjct: 287 PARTV-FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATV 341


>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
           precursor [Homo sapiens]
          Length = 456

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 68/296 (22%), Positives = 128/296 (43%), Gaps = 18/296 (6%)

Query: 31  RLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDY 90
           R+++ LLD   Y+  +RP   G  +  V+  + +     V + +   T +V+  Q W+D 
Sbjct: 44  RILDRLLDG--YDNRLRPGL-GERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDE 100

Query: 91  RLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAV--VSYDGSIFWLPP 148
           RL +K      ++   L +  IW PD   +N    +       N +  ++ DG++ +   
Sbjct: 101 RLKFKGP-MTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMR 159

Query: 149 AIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSE----VASLDDFTPSGEWD 204
              ++ C + ++ FP D   C +KF S+ Y R E+      E    V   +D +   ++D
Sbjct: 160 LTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYD 219

Query: 205 IVALPGRRN-ENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCG 263
           ++               YV +T  F ++RK  ++ I   +PC++   L+ + F+L  +  
Sbjct: 220 LLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESV 279

Query: 264 EKMTLCISVLLALTVFLLLIS------KIVPPTSLDVPLVGKYLMFTMVLVTFSIV 313
              T+   V   LT+  L IS      K+   T++D  +   Y      L+ F+ V
Sbjct: 280 PARTV-FGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATV 334


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,043,177
Number of Sequences: 37866
Number of extensions: 889318
Number of successful extensions: 3348
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3165
Number of HSP's gapped (non-prelim): 106
length of query: 502
length of database: 18,247,518
effective HSP length: 107
effective length of query: 395
effective length of database: 14,195,856
effective search space: 5607363120
effective search space used: 5607363120
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.