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Search of human proteins with 4502751
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
(168 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens] 335 8e-93
gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens] 335 8e-93
gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens] 132 2e-31
gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens] 132 2e-31
gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo ... 93 9e-20
gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1 [Homo... 91 4e-19
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 85 3e-17
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 85 3e-17
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 85 3e-17
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 85 3e-17
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 85 3e-17
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 85 3e-17
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 83 1e-16
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 83 1e-16
gi|18079216 CASK interacting protein 1 [Homo sapiens] 78 4e-15
gi|50511945 cajalin 2 isoform a [Homo sapiens] 78 4e-15
gi|116325987 ankyrin repeat domain 42 [Homo sapiens] 77 9e-15
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 76 2e-14
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 76 2e-14
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 76 2e-14
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 76 2e-14
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 76 2e-14
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 76 2e-14
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 76 2e-14
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 75 3e-14
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 75 3e-14
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 74 5e-14
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 74 5e-14
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 73 1e-13
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 73 1e-13
>gi|17981699 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
Length = 168
Score = 335 bits (860), Expect = 8e-93
Identities = 168/168 (100%), Positives = 168/168 (100%)
Query: 1 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG 60
MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
Sbjct: 1 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG 60
Query: 61 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE 120
ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
Sbjct: 61 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE 120
Query: 121 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ 168
FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
Sbjct: 121 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ 168
>gi|4502751 cyclin-dependent kinase inhibitor 2C [Homo sapiens]
Length = 168
Score = 335 bits (860), Expect = 8e-93
Identities = 168/168 (100%), Positives = 168/168 (100%)
Query: 1 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG 60
MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG
Sbjct: 1 MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRG 60
Query: 61 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE 120
ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE
Sbjct: 61 ANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE 120
Query: 121 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ 168
FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ
Sbjct: 121 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ 168
>gi|4502753 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
Length = 166
Score = 132 bits (331), Expect = 2e-31
Identities = 71/155 (45%), Positives = 104/155 (67%), Gaps = 3/155 (1%)
Query: 6 GNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPD 64
G+ L+ AAARGD++++ LL V+ +A N FG+TALQVM G+ IA LL +GA+P+
Sbjct: 9 GDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPN 68
Query: 65 LKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK 124
++D +G + +HDAAR GFLDTL+ L+E ADVN+ D G LP+HLA +EGH VV FL
Sbjct: 69 VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA- 127
Query: 125 HTASNVGHRNHKGDTACDLARLYGRNEVVSLMQAN 159
S++ R+ +G T +LA G ++V ++Q +
Sbjct: 128 -AESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
>gi|17981702 cyclin-dependent kinase inhibitor 2D [Homo sapiens]
Length = 166
Score = 132 bits (331), Expect = 2e-31
Identities = 71/155 (45%), Positives = 104/155 (67%), Gaps = 3/155 (1%)
Query: 6 GNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPD 64
G+ L+ AAARGD++++ LL V+ +A N FG+TALQVM G+ IA LL +GA+P+
Sbjct: 9 GDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPN 68
Query: 65 LKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK 124
++D +G + +HDAAR GFLDTL+ L+E ADVN+ D G LP+HLA +EGH VV FL
Sbjct: 69 VQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLA- 127
Query: 125 HTASNVGHRNHKGDTACDLARLYGRNEVVSLMQAN 159
S++ R+ +G T +LA G ++V ++Q +
Sbjct: 128 -AESDLHRRDARGLTPLELALQRGAQDLVDILQGH 161
>gi|4502749 cyclin-dependent kinase inhibitor 2A isoform 1 [Homo
sapiens]
Length = 156
Score = 93.2 bits (230), Expect = 9e-20
Identities = 56/139 (40%), Positives = 78/139 (56%), Gaps = 1/139 (0%)
Query: 3 EPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGAN 62
EP + LA+AAARG +E++ +LL+ NA N +GR +QVM +G+ +A LLL GA
Sbjct: 10 EPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAE 69
Query: 63 PDLKD-RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEF 121
P+ D T +HDAAR GFLDTL L A +++ D G LP+ LA + GH V +
Sbjct: 70 PNCADPATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEELGHRDVARY 129
Query: 122 LVKHTASNVGHRNHKGDTA 140
L G + + D A
Sbjct: 130 LRAAAGGTRGSNHARIDAA 148
>gi|17981694 cyclin-dependent kinase inhibitor 2B isoform 1 [Homo
sapiens]
Length = 138
Score = 91.3 bits (225), Expect = 4e-19
Identities = 53/115 (46%), Positives = 70/115 (60%), Gaps = 1/115 (0%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKD- 67
LASAAARG +E++ LL+ + N N FGR A+QVM +G+ +A LLL GA P+ D
Sbjct: 18 LASAAARGLVEKVRQLLEAGADPNGVNRFGRRAIQVMMMGSARVAELLLLHGAEPNCADP 77
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFL 122
T +HDAAR GFLDTL L A +++ D G LP+ LA + GH V +L
Sbjct: 78 ATLTRPVHDAAREGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYL 132
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 84.7 bits (208), Expect = 3e-17
Identities = 54/151 (35%), Positives = 82/151 (54%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G +E L ++ + V+V AQ+ G +AL + K + E R+LL + D +G
Sbjct: 63 AAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG 122
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AA G L +Q L E ++ +N++D +GN+PL LA + GH + FL+ H A +V
Sbjct: 123 KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGA-DV 181
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
RN G TA LA G + V + GA
Sbjct: 182 NSRNKSGRTALMLACEIGSSNAVEALIKKGA 212
Score = 46.6 bits (109), Expect = 1e-05
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 6/118 (5%)
Query: 42 LQVMKLGNPE-IARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIED 100
LQ ++ G+ E +A L +GA+ D G H AA G ++ L+ ++ DV +D
Sbjct: 27 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 86
Query: 101 NEGNLPLHLAAKEGHLRVVEFLV--KHTASNVGHRNHKGDTACDLARLYGRNEVVSLM 156
G+ LHLAAK H + L+ K A +V + G TA A G + V ++
Sbjct: 87 TTGHSALHLAAKNSHHECIRKLLQSKCPAESV---DSSGKTALHYAAAQGCLQAVQIL 141
Score = 39.7 bits (91), Expect = 0.001
Identities = 27/98 (27%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G L+ + L ++ +N ++ G L + ++ G+ EI LL GA+ + ++++G
Sbjct: 129 AAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSG 188
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLH 108
+ A G + ++ L++ AD+N+ D+ G LH
Sbjct: 189 RTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 226
Score = 37.7 bits (86), Expect = 0.005
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 4/92 (4%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKD 67
L A G E LL + +VN++N GRTAL + ++G+ L+ +GA+ +L D
Sbjct: 159 LLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 218
Query: 68 RTGFAVIHD---AARAGFLDTLQTLLEFQADV 96
G+ +H + AG L + + AD+
Sbjct: 219 SLGYNALHYSKLSENAGIQSLLLSKISQDADL 250
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 84.7 bits (208), Expect = 3e-17
Identities = 54/151 (35%), Positives = 82/151 (54%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G +E L ++ + V+V AQ+ G +AL + K + E R+LL + D +G
Sbjct: 52 AAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG 111
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AA G L +Q L E ++ +N++D +GN+PL LA + GH + FL+ H A +V
Sbjct: 112 KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGA-DV 170
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
RN G TA LA G + V + GA
Sbjct: 171 NSRNKSGRTALMLACEIGSSNAVEALIKKGA 201
Score = 46.6 bits (109), Expect = 1e-05
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 6/118 (5%)
Query: 42 LQVMKLGNPE-IARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIED 100
LQ ++ G+ E +A L +GA+ D G H AA G ++ L+ ++ DV +D
Sbjct: 16 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 75
Query: 101 NEGNLPLHLAAKEGHLRVVEFLV--KHTASNVGHRNHKGDTACDLARLYGRNEVVSLM 156
G+ LHLAAK H + L+ K A +V + G TA A G + V ++
Sbjct: 76 TTGHSALHLAAKNSHHECIRKLLQSKCPAESV---DSSGKTALHYAAAQGCLQAVQIL 130
Score = 39.7 bits (91), Expect = 0.001
Identities = 27/98 (27%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G L+ + L ++ +N ++ G L + ++ G+ EI LL GA+ + ++++G
Sbjct: 118 AAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSG 177
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLH 108
+ A G + ++ L++ AD+N+ D+ G LH
Sbjct: 178 RTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 215
Score = 37.7 bits (86), Expect = 0.005
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 4/92 (4%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKD 67
L A G E LL + +VN++N GRTAL + ++G+ L+ +GA+ +L D
Sbjct: 148 LLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 207
Query: 68 RTGFAVIHD---AARAGFLDTLQTLLEFQADV 96
G+ +H + AG L + + AD+
Sbjct: 208 SLGYNALHYSKLSENAGIQSLLLSKISQDADL 239
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 84.7 bits (208), Expect = 3e-17
Identities = 54/151 (35%), Positives = 82/151 (54%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G +E L ++ + V+V AQ+ G +AL + K + E R+LL + D +G
Sbjct: 60 AAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG 119
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AA G L +Q L E ++ +N++D +GN+PL LA + GH + FL+ H A +V
Sbjct: 120 KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGA-DV 178
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
RN G TA LA G + V + GA
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
Score = 46.6 bits (109), Expect = 1e-05
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 6/118 (5%)
Query: 42 LQVMKLGNPE-IARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIED 100
LQ ++ G+ E +A L +GA+ D G H AA G ++ L+ ++ DV +D
Sbjct: 24 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 83
Query: 101 NEGNLPLHLAAKEGHLRVVEFLV--KHTASNVGHRNHKGDTACDLARLYGRNEVVSLM 156
G+ LHLAAK H + L+ K A +V + G TA A G + V ++
Sbjct: 84 TTGHSALHLAAKNSHHECIRKLLQSKCPAESV---DSSGKTALHYAAAQGCLQAVQIL 138
Score = 39.7 bits (91), Expect = 0.001
Identities = 27/98 (27%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G L+ + L ++ +N ++ G L + ++ G+ EI LL GA+ + ++++G
Sbjct: 126 AAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSG 185
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLH 108
+ A G + ++ L++ AD+N+ D+ G LH
Sbjct: 186 RTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
Score = 37.7 bits (86), Expect = 0.005
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 4/92 (4%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKD 67
L A G E LL + +VN++N GRTAL + ++G+ L+ +GA+ +L D
Sbjct: 156 LLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 215
Query: 68 RTGFAVIHD---AARAGFLDTLQTLLEFQADV 96
G+ +H + AG L + + AD+
Sbjct: 216 SLGYNALHYSKLSENAGIQSLLLSKISQDADL 247
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 84.7 bits (208), Expect = 3e-17
Identities = 54/151 (35%), Positives = 82/151 (54%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G +E L ++ + V+V AQ+ G +AL + K + E R+LL + D +G
Sbjct: 60 AAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG 119
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AA G L +Q L E ++ +N++D +GN+PL LA + GH + FL+ H A +V
Sbjct: 120 KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGA-DV 178
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
RN G TA LA G + V + GA
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
Score = 46.6 bits (109), Expect = 1e-05
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 6/118 (5%)
Query: 42 LQVMKLGNPE-IARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIED 100
LQ ++ G+ E +A L +GA+ D G H AA G ++ L+ ++ DV +D
Sbjct: 24 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 83
Query: 101 NEGNLPLHLAAKEGHLRVVEFLV--KHTASNVGHRNHKGDTACDLARLYGRNEVVSLM 156
G+ LHLAAK H + L+ K A +V + G TA A G + V ++
Sbjct: 84 TTGHSALHLAAKNSHHECIRKLLQSKCPAESV---DSSGKTALHYAAAQGCLQAVQIL 138
Score = 39.7 bits (91), Expect = 0.001
Identities = 27/98 (27%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G L+ + L ++ +N ++ G L + ++ G+ EI LL GA+ + ++++G
Sbjct: 126 AAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSG 185
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLH 108
+ A G + ++ L++ AD+N+ D+ G LH
Sbjct: 186 RTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
Score = 37.7 bits (86), Expect = 0.005
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 4/92 (4%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKD 67
L A G E LL + +VN++N GRTAL + ++G+ L+ +GA+ +L D
Sbjct: 156 LLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 215
Query: 68 RTGFAVIHD---AARAGFLDTLQTLLEFQADV 96
G+ +H + AG L + + AD+
Sbjct: 216 SLGYNALHYSKLSENAGIQSLLLSKISQDADL 247
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 84.7 bits (208), Expect = 3e-17
Identities = 54/151 (35%), Positives = 82/151 (54%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G +E L ++ + V+V AQ+ G +AL + K + E R+LL + D +G
Sbjct: 60 AAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG 119
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AA G L +Q L E ++ +N++D +GN+PL LA + GH + FL+ H A +V
Sbjct: 120 KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGA-DV 178
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
RN G TA LA G + V + GA
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
Score = 46.6 bits (109), Expect = 1e-05
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 6/118 (5%)
Query: 42 LQVMKLGNPE-IARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIED 100
LQ ++ G+ E +A L +GA+ D G H AA G ++ L+ ++ DV +D
Sbjct: 24 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 83
Query: 101 NEGNLPLHLAAKEGHLRVVEFLV--KHTASNVGHRNHKGDTACDLARLYGRNEVVSLM 156
G+ LHLAAK H + L+ K A +V + G TA A G + V ++
Sbjct: 84 TTGHSALHLAAKNSHHECIRKLLQSKCPAESV---DSSGKTALHYAAAQGCLQAVQIL 138
Score = 39.7 bits (91), Expect = 0.001
Identities = 27/98 (27%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G L+ + L ++ +N ++ G L + ++ G+ EI LL GA+ + ++++G
Sbjct: 126 AAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSG 185
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLH 108
+ A G + ++ L++ AD+N+ D+ G LH
Sbjct: 186 RTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
Score = 37.7 bits (86), Expect = 0.005
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 4/92 (4%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKD 67
L A G E LL + +VN++N GRTAL + ++G+ L+ +GA+ +L D
Sbjct: 156 LLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 215
Query: 68 RTGFAVIHD---AARAGFLDTLQTLLEFQADV 96
G+ +H + AG L + + AD+
Sbjct: 216 SLGYNALHYSKLSENAGIQSLLLSKISQDADL 247
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 84.7 bits (208), Expect = 3e-17
Identities = 54/151 (35%), Positives = 82/151 (54%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G +E L ++ + V+V AQ+ G +AL + K + E R+LL + D +G
Sbjct: 60 AAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSG 119
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AA G L +Q L E ++ +N++D +GN+PL LA + GH + FL+ H A +V
Sbjct: 120 KTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGA-DV 178
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
RN G TA LA G + V + GA
Sbjct: 179 NSRNKSGRTALMLACEIGSSNAVEALIKKGA 209
Score = 46.6 bits (109), Expect = 1e-05
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 6/118 (5%)
Query: 42 LQVMKLGNPE-IARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIED 100
LQ ++ G+ E +A L +GA+ D G H AA G ++ L+ ++ DV +D
Sbjct: 24 LQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQD 83
Query: 101 NEGNLPLHLAAKEGHLRVVEFLV--KHTASNVGHRNHKGDTACDLARLYGRNEVVSLM 156
G+ LHLAAK H + L+ K A +V + G TA A G + V ++
Sbjct: 84 TTGHSALHLAAKNSHHECIRKLLQSKCPAESV---DSSGKTALHYAAAQGCLQAVQIL 138
Score = 39.7 bits (91), Expect = 0.001
Identities = 27/98 (27%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTG 70
AAA+G L+ + L ++ +N ++ G L + ++ G+ EI LL GA+ + ++++G
Sbjct: 126 AAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSG 185
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLH 108
+ A G + ++ L++ AD+N+ D+ G LH
Sbjct: 186 RTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALH 223
Score = 37.7 bits (86), Expect = 0.005
Identities = 27/92 (29%), Positives = 45/92 (48%), Gaps = 4/92 (4%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKD 67
L A G E LL + +VN++N GRTAL + ++G+ L+ +GA+ +L D
Sbjct: 156 LLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVD 215
Query: 68 RTGFAVIHD---AARAGFLDTLQTLLEFQADV 96
G+ +H + AG L + + AD+
Sbjct: 216 SLGYNALHYSKLSENAGIQSLLLSKISQDADL 247
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 83.2 bits (204), Expect = 1e-16
Identities = 52/156 (33%), Positives = 82/156 (52%), Gaps = 2/156 (1%)
Query: 7 NELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNP-EIARRLLLRGANPDL 65
N L AA G + + L + +VN ++ GR L ++ L N +A L GAN +
Sbjct: 915 NALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEA 974
Query: 66 KDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKH 125
D G +H + G ++ +Q L+ + ADVN DNE L AA +GH++VV+ L++H
Sbjct: 975 SDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEH 1034
Query: 126 TASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
A V H ++G TA +A G +VV ++ +GA
Sbjct: 1035 GAV-VDHTCNQGATALCIAAQEGHIDVVQVLLEHGA 1069
Score = 80.9 bits (198), Expect = 5e-16
Identities = 52/154 (33%), Positives = 84/154 (54%), Gaps = 2/154 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDLKD 67
L +AA+ G + +LL V++ + GRT L + GN E+ R LL RG + + +D
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
G+ +H AA G + L+E A N DN+G +P LA++EGH V+ L+++
Sbjct: 845 DAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN-K 903
Query: 128 SNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
SN+ R + G A +A L G ++V L+ ++GA
Sbjct: 904 SNIDQRGYDGRNALRVAALEGHRDIVELLFSHGA 937
Score = 70.9 bits (172), Expect = 5e-13
Identities = 56/158 (35%), Positives = 75/158 (47%), Gaps = 7/158 (4%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL------GNPEIARRLLLRGAN 62
L +AA G E + LL + VN ++ GRTAL V L G+ + L+ RGA
Sbjct: 681 LIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE 740
Query: 63 PDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFL 122
D D+ G + AA G +D + LLE ADV+ DN G PL AA GH VV L
Sbjct: 741 VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 800
Query: 123 VKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANG 160
+ A+ V + +G T +A G EVV + G
Sbjct: 801 LFWGAA-VDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
Score = 68.6 bits (166), Expect = 2e-12
Identities = 55/159 (34%), Positives = 73/159 (45%), Gaps = 7/159 (4%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLG-NPEIARRLLLRGANPDLKD 67
L AA +G + + L+ N+N + G TAL+ G + E+ LL G D D
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD 641
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+ AA G D + LL+ A+VN DNEG L AA GH +VE L+ H A
Sbjct: 642 ADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA 701
Query: 128 SNVGHRNHKGDTACDLARL-----YGRNEVVSLMQANGA 161
V H + G TA +A L G VVSL+ GA
Sbjct: 702 -EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGA 739
Score = 68.2 bits (165), Expect = 3e-12
Identities = 49/139 (35%), Positives = 76/139 (54%), Gaps = 4/139 (2%)
Query: 19 EQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTGFAVIHDA 77
E L L++ +VN+++ RT+ V + L + R LL GA+ + D G ++ +A
Sbjct: 495 EVLQLLVKAGAHVNSEDD--RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552
Query: 78 ARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKG 137
A +G LD + L+ AD+ IED G+ PL LAA++GH +VV L+ +N+ H + G
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLI-GCGANINHTDQDG 611
Query: 138 DTACDLARLYGRNEVVSLM 156
TA A G EVVS +
Sbjct: 612 WTALRSAAWGGHTEVVSAL 630
Score = 61.2 bits (147), Expect = 4e-10
Identities = 38/117 (32%), Positives = 64/117 (54%), Gaps = 1/117 (0%)
Query: 15 RGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDLKDRTGFAV 73
+G +E + L+ + +VNA + R+ALQ G+ ++ + L+ GA D G
Sbjct: 989 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 1048
Query: 74 IHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ AA+ G +D +Q LLE AD N D G + +AAK GH ++++ L K+ AS++
Sbjct: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL 1105
Score = 52.0 bits (123), Expect = 2e-07
Identities = 41/144 (28%), Positives = 67/144 (46%), Gaps = 2/144 (1%)
Query: 19 EQLTSLLQNNVNVNAQNGFGRTAL-QVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDA 77
+ + +LL N +VN + GRT L G+ ++ L+ RGA+ +++D G + A
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 78 ARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKG 137
AR G + L+ A++N D +G L AA GH VV L+ + V +
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL-YAGVKVDCADADS 644
Query: 138 DTACDLARLYGRNEVVSLMQANGA 161
TA A G ++V + +GA
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGA 668
Score = 30.4 bits (67), Expect = 0.75
Identities = 19/55 (34%), Positives = 32/55 (58%), Gaps = 1/55 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGAN 62
L AA G ++ + LL++ + N + FGRTA++V K G+ +I + L GA+
Sbjct: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 82.8 bits (203), Expect = 1e-16
Identities = 55/157 (35%), Positives = 82/157 (52%), Gaps = 2/157 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G LE+ ++N V++N N G AL + K G+ E+ LL R AN D + G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H A+ AG + ++ L+ A+VN + G PL++AA+E HL VV+FL+ + AS
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ- 166
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNL 167
G T +A G ++VVSL+ N G L
Sbjct: 167 SLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRL 203
Score = 76.6 bits (187), Expect = 9e-15
Identities = 54/151 (35%), Positives = 75/151 (49%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA G LE LLQ + + +A G T L V N ++A LL +GA+P + G
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H AA+ +D TLLE+ AD N +G +HLAA+EGH+ +V L+ A NV
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA-NV 690
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
N G T LA R V ++ GA
Sbjct: 691 NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGA 721
Score = 72.4 bits (176), Expect = 2e-13
Identities = 52/151 (34%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 13 AARGD-LEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
A +GD L + LLQ+NV V+ TAL V G+ ++A+ LL + ANP+ K G
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG 400
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
F +H A + + ++ LL+ A + G P+H+AA GH+ +V L+ H AS
Sbjct: 401 FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS-P 459
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
N +G+TA +A G+ EVV + +GA
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGA 490
Score = 72.0 bits (175), Expect = 2e-13
Identities = 50/154 (32%), Positives = 78/154 (50%), Gaps = 2/154 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKD 67
L AA G E + L+Q+ V A+ +T L + +LG +I ++LL +GA+P+
Sbjct: 470 LHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAAT 529
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+G+ +H +AR G D LL+ A ++I +G PLH+AAK G L V L++ +A
Sbjct: 530 TSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSA 589
Query: 128 SNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
S G T +A Y +V L+ GA
Sbjct: 590 S-PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGA 622
Score = 71.6 bits (174), Expect = 3e-13
Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 2/147 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G ++ ++ LL N NVN N G T L + + +A L+ +GA+ D + + G
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMG 730
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H G + + LL+ A VN + G PLH AA++GH ++ L+++ AS
Sbjct: 731 YTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS-P 789
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQ 157
G+TA +AR G VV ++
Sbjct: 790 NELTVNGNTALGIARRLGYISVVDTLK 816
Score = 68.2 bits (165), Expect = 3e-12
Identities = 39/120 (32%), Positives = 68/120 (56%), Gaps = 1/120 (0%)
Query: 7 NELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDL 65
N L A+ G +E ++ LLQ NV+A G TAL + L G E+ + L+ GAN +
Sbjct: 76 NALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNA 135
Query: 66 KDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKH 125
+ + GF ++ AA+ L+ ++ LL+ A ++ +G PL +A ++GH +VV L+++
Sbjct: 136 QSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN 195
Score = 61.6 bits (148), Expect = 3e-10
Identities = 38/117 (32%), Positives = 60/117 (51%), Gaps = 1/117 (0%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA + D + LLQN+ N + ++ G T L + GN +A LL R A D R
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+H A++ G + ++ LL+ A ++ + +G PLH A+ GH +VVE L+ A
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA 325
Score = 57.8 bits (138), Expect = 4e-09
Identities = 39/115 (33%), Positives = 56/115 (48%), Gaps = 1/115 (0%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G++ T LL V+ T L V K GN + + LL RGA D K R G
Sbjct: 242 AAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG 301
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKH 125
+H AR+G ++ LL+ A + + G PLH+A + HL V+ L++H
Sbjct: 302 LTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 55.5 bits (132), Expect = 2e-08
Identities = 35/120 (29%), Positives = 63/120 (52%), Gaps = 1/120 (0%)
Query: 42 LQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDN 101
L+ + G+ E A + G + ++ ++ G +H A++ G ++ + LL+ +A+V+
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATK 105
Query: 102 EGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+GN LH+A+ G VV+ LV + A NV ++ G T +A EVV + NGA
Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGA-NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGA 164
Score = 55.5 bits (132), Expect = 2e-08
Identities = 38/151 (25%), Positives = 75/151 (49%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
A + ++ + LL++ ++ A G T + V +G+ I +L+ GA+P+ + G
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AAR+G + ++ L++ A V + + PLH++A+ G +V+ L++ AS
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGAS-P 525
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
G T L+ G +V + + +GA
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGA 556
Score = 53.1 bits (126), Expect = 1e-07
Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTG 70
A+ RG+ + LL ++A+ G T L + G+ ++ LL R A K + G
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 334
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H A + L+ +Q LL+ V+ N+ LH+AA GH +V + L+ A N
Sbjct: 335 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA-NP 393
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+ G T +A R +V+ L+ +GA
Sbjct: 394 NAKALNGFTPLHIACKKNRIKVMELLLKHGA 424
Score = 51.6 bits (122), Expect = 3e-07
Identities = 36/118 (30%), Positives = 57/118 (48%), Gaps = 1/118 (0%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
+A G + + LLQ + NA G T L + + G+ ++A LL GA+ + + G
Sbjct: 506 SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 565
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS 128
F +H AA+ G L+ LL+ A + G PLH+AA + +V L+ AS
Sbjct: 566 FTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGAS 623
Score = 47.8 bits (112), Expect = 5e-06
Identities = 47/180 (26%), Positives = 68/180 (37%), Gaps = 31/180 (17%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNP-EIARRLLLRGANPDLKDRTG 70
A+ G E + L+ N NVNAQ+ G T L + N E+ + LL GA+ L G
Sbjct: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDG 173
Query: 71 FA-----------------------------VIHDAARAGFLDTLQTLLEFQADVNIEDN 101
F +H AAR LL+ + ++E
Sbjct: 174 FTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESK 233
Query: 102 EGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
G PLH+AA G++ V L+ A+ V T +A G +V L+ GA
Sbjct: 234 SGFTPLHIAAHYGNINVATLLLNRAAA-VDFTARNDITPLHVASKRGNANMVKLLLDRGA 292
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 77.8 bits (190), Expect = 4e-15
Identities = 52/129 (40%), Positives = 74/129 (57%), Gaps = 2/129 (1%)
Query: 29 VNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQ 87
+NVN Q+ G +AL L GN E+ LL A D+KD G +H AA G + ++
Sbjct: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
Query: 88 TLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLY 147
+L+ + VNI +EG++PLHLAA+ GH V E L++H SN ++ G T DLA +
Sbjct: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQH-QSNPCMVDNSGKTPLDLACEF 158
Query: 148 GRNEVVSLM 156
GR VV L+
Sbjct: 159 GRVGVVQLL 167
Score = 51.2 bits (121), Expect = 4e-07
Identities = 50/192 (26%), Positives = 77/192 (40%), Gaps = 40/192 (20%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDLKD 67
L AA G+ E ++ LL+ V+ ++ G L G E + +L G+ ++
Sbjct: 53 LHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPS 112
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK--- 124
G +H AA+ G D + LL+ Q++ + DN G PL LA + G + VV+ L+
Sbjct: 113 DEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNM 172
Query: 125 ---------------------HTASNVGH---------------RNHKGDTACDLARLYG 148
H A+ GH R K TA A L G
Sbjct: 173 CAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCG 232
Query: 149 RNEVVSLMQANG 160
+ EVV L+ +G
Sbjct: 233 KTEVVRLLLDSG 244
Score = 32.0 bits (71), Expect = 0.26
Identities = 18/67 (26%), Positives = 32/67 (47%), Gaps = 3/67 (4%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKD---R 68
AA G ++ + LLQ +++N Q G + G E+ R LL G N +++ +
Sbjct: 196 AAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQ 255
Query: 69 TGFAVIH 75
T ++H
Sbjct: 256 TALDIVH 262
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 77.8 bits (190), Expect = 4e-15
Identities = 47/151 (31%), Positives = 77/151 (50%), Gaps = 11/151 (7%)
Query: 8 ELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKD 67
EL AA G++ + LL G G L + + RG N + D
Sbjct: 6 ELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLS---------IWRGPNVNCTD 56
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKH-- 125
+G+ +H AA G D + LL+++A N+ DN+G P+HLAA +G + +V+ L+ H
Sbjct: 57 SSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGP 116
Query: 126 TASNVGHRNHKGDTACDLARLYGRNEVVSLM 156
+ S V +N++ +TA A YG +EVV+++
Sbjct: 117 SHSRVNEQNNENETALHCAAQYGHSEVVAVL 147
Score = 45.4 bits (106), Expect = 2e-05
Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 5/156 (3%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRG---ANPD 64
L AA G + + LLQ + N + G + + G+ EI + L+ G + +
Sbjct: 63 LHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVN 122
Query: 65 LKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK 124
++ +H AA+ G + + LLE D I +++ PL LAA G LRVV+ ++
Sbjct: 123 EQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIIS 182
Query: 125 HTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANG 160
N+ N + T LA G VV ++ G
Sbjct: 183 -AHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAG 217
Score = 35.8 bits (81), Expect = 0.018
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 2/99 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G L + ++ + N+ + N T L + + G+ + + LL G + + G
Sbjct: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG 227
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHL 109
A +H+AA G +D ++ LLE D NI+D+ G L +
Sbjct: 228 SA-LHEAALFGKVDVVRVLLETGIDANIKDSLGRTVLDI 265
>gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
Length = 389
Score = 76.6 bits (187), Expect = 9e-15
Identities = 48/150 (32%), Positives = 77/150 (51%), Gaps = 4/150 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLR-GANPDLKDRTG 70
AA RG + +L+ N N+ AQ+ G T L + +++LR G +P + D+
Sbjct: 72 AAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKRE 131
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASN- 129
+ +H AA G L LQ L+++ + D GNLP+HLAA EGHL +FLV +S
Sbjct: 132 WRPVHYAAFHGRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSAT 191
Query: 130 --VGHRNHKGDTACDLARLYGRNEVVSLMQ 157
+ N G+ DLA+ + + ++ +Q
Sbjct: 192 QVLKAFNDNGENVLDLAQRFFKQNILQFIQ 221
Score = 42.4 bits (98), Expect = 2e-04
Identities = 31/97 (31%), Positives = 53/97 (54%), Gaps = 5/97 (5%)
Query: 64 DLKDRTGFAVI-HDAARAGFLDTLQTLLEFQA-DVNIEDNEGNLPLHLAAKEGHLRVVEF 121
DL+D+ A H AA G L L+ L+E ++N + G+ P+H AA +GH+ +++
Sbjct: 229 DLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQW 288
Query: 122 LVKHTA-SNVGHRNHKGDTACDLARLYGRNEVVSLMQ 157
L+K A SN+ N G+ D+A+ + V L++
Sbjct: 289 LIKMGADSNI--TNKAGERPSDVAKRFAHLAAVKLLE 323
Score = 40.8 bits (94), Expect = 6e-04
Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 7/106 (6%)
Query: 61 ANPDLKDRTGFAVIHDAARAGFLDTLQT------LLEFQADVNIEDNEGNLPLHLAAKEG 114
ANP + + F IHDA RAG + L LL AD+ G H+AA G
Sbjct: 17 ANPCSRKKVHFGSIHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRG 76
Query: 115 HLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANG 160
V+ L+ + A N+ ++ +G T LA +G + + +M +G
Sbjct: 77 QDACVQALIMNGA-NLTAQDDRGCTPLHLAATHGHSFTLQIMLRSG 121
Score = 36.6 bits (83), Expect = 0.010
Identities = 22/69 (31%), Positives = 35/69 (50%)
Query: 56 LLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGH 115
LL GA+ G+ H AA G +Q L+ A++ +D+ G PLHLAA GH
Sbjct: 51 LLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLTAQDDRGCTPLHLAATHGH 110
Query: 116 LRVVEFLVK 124
++ +++
Sbjct: 111 SFTLQIMLR 119
Score = 27.3 bits (59), Expect = 6.3
Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 97 NIEDNEG-NLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSL 155
++ED E P H+AA +G L +++ LV+ N+ R G T A G E +
Sbjct: 229 DLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQW 288
Query: 156 MQANGA 161
+ GA
Sbjct: 289 LIKMGA 294
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 75.9 bits (185), Expect = 2e-14
Identities = 46/157 (29%), Positives = 85/157 (54%), Gaps = 2/157 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G+L+++ L+ +++N N G AL + K G+ + + LL RG++ D + G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H A+ AG + ++ L++ A++N + G PL++AA+E H+ VV++L+++ A N
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA-NQ 135
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNL 167
G T +A G N+ V+++ N G L
Sbjct: 136 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL 172
Score = 70.9 bits (172), Expect = 5e-13
Identities = 51/154 (33%), Positives = 76/154 (49%), Gaps = 2/154 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKD 67
L AA G +E + LL+N V+A+ +T L + +LG EI + LL A+PD
Sbjct: 447 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 506
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
G+ +H +AR G +D LLE A ++ +G PLH+AAK G L V + L++ A
Sbjct: 507 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 566
Query: 128 SNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+ G T +A Y +V L+ GA
Sbjct: 567 A-ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 599
Score = 69.7 bits (169), Expect = 1e-12
Identities = 48/151 (31%), Positives = 73/151 (48%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA G L+ LLQ ++ G T L V N ++A LL +GA+P + G
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H AA+ + TLL + A+ NI +G PLHLA++EGH +V L+ A N+
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NI 667
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
G T+ LA + V ++ +GA
Sbjct: 668 HMSTKSGLTSLHLAAQEDKVNVADILTKHGA 698
Score = 67.0 bits (162), Expect = 7e-12
Identities = 49/151 (32%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 13 AARGD-LEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA+GD +E + LLQ+ V+ TAL V G+ + + LL + ANP+ + G
Sbjct: 318 AAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG 377
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
F +H A + + ++ L+++ A + G P+H+AA GHL +V L+++ AS
Sbjct: 378 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS-P 436
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
N +G+TA +A G+ EVV + NGA
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGA 467
Score = 61.2 bits (147), Expect = 4e-10
Identities = 42/117 (35%), Positives = 58/117 (49%), Gaps = 1/117 (0%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G++ T LL V+ G T L V K GN + + LL RG D K R G
Sbjct: 219 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 278
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+H AAR+G ++ LLE A + G PLH+AA+ H+ V+ L++H A
Sbjct: 279 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 335
Score = 59.7 bits (143), Expect = 1e-09
Identities = 42/151 (27%), Positives = 76/151 (50%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
A + ++ + L++ ++ A G T + V +G+ I LL GA+PD+ + G
Sbjct: 384 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 443
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AARAG ++ ++ LL A V+ E PLH+A++ G +V+ L++H A +
Sbjct: 444 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA-HP 502
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
G T ++ G+ +V S++ GA
Sbjct: 503 DAATTNGYTPLHISAREGQVDVASVLLEAGA 533
Score = 58.9 bits (141), Expect = 2e-09
Identities = 42/148 (28%), Positives = 71/148 (47%), Gaps = 4/148 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNP-EIARRLLLRGANPDLKDRTG 70
A+ G + +T LL N++ G T+L + + +A L GA+ D + G
Sbjct: 648 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 707
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS-N 129
+ + A G + + LL+ A+VN + G PLH AA++GH ++ L++H A N
Sbjct: 708 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 767
Query: 130 VGHRNHKGDTACDLARLYGRNEVVSLMQ 157
N G+TA +A+ G VV ++
Sbjct: 768 ATTAN--GNTALAIAKRLGYISVVDTLK 793
Score = 58.2 bits (139), Expect = 3e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 2/139 (1%)
Query: 24 LLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGF 82
LL+ + +A G T L + K +IA LL GA ++ + G +H A++ G
Sbjct: 594 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 653
Query: 83 LDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACD 142
D + LL+ A++++ G LHLAA+E + V + L KH A H G T
Sbjct: 654 TDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH-TKLGYTPLI 712
Query: 143 LARLYGRNEVVSLMQANGA 161
+A YG ++V+ + GA
Sbjct: 713 VACHYGNVKMVNFLLKQGA 731
Score = 52.8 bits (125), Expect = 1e-07
Identities = 43/151 (28%), Positives = 73/151 (48%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKDRTG 70
A+ RG+ + LL ++A+ G T L + G+ ++ LL RGA + + G
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H AA+ ++ ++ LL+ +A V+ + LH+AA GH RV + L+ A N
Sbjct: 312 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA-NP 370
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
R G T +A R +V+ L+ GA
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGA 401
Score = 52.8 bits (125), Expect = 1e-07
Identities = 46/152 (30%), Positives = 72/152 (47%), Gaps = 4/152 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
A+ G E + LLQ+ + +A G T L + + G ++A LL GA L + G
Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 542
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
F +H AA+ G LD + LL+ +A + G PLH+AA + +V L++ AS
Sbjct: 543 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS-- 600
Query: 131 GHRNHK-GDTACDLARLYGRNEVVSLMQANGA 161
H K G T +A + ++ S + GA
Sbjct: 601 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632
Score = 52.0 bits (123), Expect = 2e-07
Identities = 36/124 (29%), Positives = 60/124 (48%), Gaps = 1/124 (0%)
Query: 42 LQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDN 101
L+ + GN + L G + + ++ G +H AA+ G + +Q LL + V+
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 74
Query: 102 EGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+GN LH+A+ G VV+ LVK A N+ ++ G T +A +VV + NGA
Sbjct: 75 KGNTALHIASLAGQAEVVKVLVKEGA-NINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 133
Query: 162 GGAT 165
+T
Sbjct: 134 NQST 137
Score = 46.6 bits (109), Expect = 1e-05
Identities = 42/165 (25%), Positives = 71/165 (43%), Gaps = 20/165 (12%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLG----NPEIARRLLLRGANPD 64
LA A +G + + LL+N+ G+ L + + + + A LL N D
Sbjct: 146 LAVALQQGHNQAVAILLENDTK-------GKVRLPALHIAARKDDTKSAALLLQNDHNAD 198
Query: 65 LKDR--------TGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHL 116
++ + +GF +H AA G ++ LL A V+ G PLH+A+K G+
Sbjct: 199 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 258
Query: 117 RVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+V+ L+ + + G T A G ++VV L+ GA
Sbjct: 259 NMVKLLLDR-GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 302
Score = 42.0 bits (97), Expect = 2e-04
Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 14/161 (8%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDR 68
+AS A + ++ ++ N+N +QNGF + + + ++ + LL GAN
Sbjct: 82 IASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE-NHIDVVKYLLENGANQSTATE 140
Query: 69 TGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLP-LHLAAKEGHLRVVEFLVK--H 125
GF + A + G + LLE N + LP LH+AA++ + L++ H
Sbjct: 141 DGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDH 195
Query: 126 TAS-----NVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
A V G T +A YG V +L+ GA
Sbjct: 196 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 236
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 75.9 bits (185), Expect = 2e-14
Identities = 46/157 (29%), Positives = 85/157 (54%), Gaps = 2/157 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G+L+++ L+ +++N N G AL + K G+ + + LL RG++ D + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H A+ AG + ++ L++ A++N + G PL++AA+E H+ VV++L+++ A N
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA-NQ 156
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNL 167
G T +A G N+ V+++ N G L
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL 193
Score = 70.9 bits (172), Expect = 5e-13
Identities = 51/154 (33%), Positives = 76/154 (49%), Gaps = 2/154 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKD 67
L AA G +E + LL+N V+A+ +T L + +LG EI + LL A+PD
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
G+ +H +AR G +D LLE A ++ +G PLH+AAK G L V + L++ A
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 128 SNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+ G T +A Y +V L+ GA
Sbjct: 588 A-ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
Score = 69.7 bits (169), Expect = 1e-12
Identities = 48/151 (31%), Positives = 73/151 (48%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA G L+ LLQ ++ G T L V N ++A LL +GA+P + G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H AA+ + TLL + A+ NI +G PLHLA++EGH +V L+ A N+
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NI 688
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
G T+ LA + V ++ +GA
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719
Score = 67.0 bits (162), Expect = 7e-12
Identities = 49/151 (32%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 13 AARGD-LEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA+GD +E + LLQ+ V+ TAL V G+ + + LL + ANP+ + G
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG 398
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
F +H A + + ++ L+++ A + G P+H+AA GHL +V L+++ AS
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS-P 457
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
N +G+TA +A G+ EVV + NGA
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Score = 61.2 bits (147), Expect = 4e-10
Identities = 42/117 (35%), Positives = 58/117 (49%), Gaps = 1/117 (0%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G++ T LL V+ G T L V K GN + + LL RG D K R G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+H AAR+G ++ LLE A + G PLH+AA+ H+ V+ L++H A
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356
Score = 59.7 bits (143), Expect = 1e-09
Identities = 42/151 (27%), Positives = 76/151 (50%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
A + ++ + L++ ++ A G T + V +G+ I LL GA+PD+ + G
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AARAG ++ ++ LL A V+ E PLH+A++ G +V+ L++H A +
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA-HP 523
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
G T ++ G+ +V S++ GA
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Score = 58.9 bits (141), Expect = 2e-09
Identities = 42/148 (28%), Positives = 71/148 (47%), Gaps = 4/148 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNP-EIARRLLLRGANPDLKDRTG 70
A+ G + +T LL N++ G T+L + + +A L GA+ D + G
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS-N 129
+ + A G + + LL+ A+VN + G PLH AA++GH ++ L++H A N
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 130 VGHRNHKGDTACDLARLYGRNEVVSLMQ 157
N G+TA +A+ G VV ++
Sbjct: 789 ATTAN--GNTALAIAKRLGYISVVDTLK 814
Score = 58.2 bits (139), Expect = 3e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 2/139 (1%)
Query: 24 LLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGF 82
LL+ + +A G T L + K +IA LL GA ++ + G +H A++ G
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
Query: 83 LDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACD 142
D + LL+ A++++ G LHLAA+E + V + L KH A H G T
Sbjct: 675 TDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH-TKLGYTPLI 733
Query: 143 LARLYGRNEVVSLMQANGA 161
+A YG ++V+ + GA
Sbjct: 734 VACHYGNVKMVNFLLKQGA 752
Score = 52.8 bits (125), Expect = 1e-07
Identities = 43/151 (28%), Positives = 73/151 (48%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKDRTG 70
A+ RG+ + LL ++A+ G T L + G+ ++ LL RGA + + G
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H AA+ ++ ++ LL+ +A V+ + LH+AA GH RV + L+ A N
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA-NP 391
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
R G T +A R +V+ L+ GA
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Score = 52.8 bits (125), Expect = 1e-07
Identities = 46/152 (30%), Positives = 72/152 (47%), Gaps = 4/152 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
A+ G E + LLQ+ + +A G T L + + G ++A LL GA L + G
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
F +H AA+ G LD + LL+ +A + G PLH+AA + +V L++ AS
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS-- 621
Query: 131 GHRNHK-GDTACDLARLYGRNEVVSLMQANGA 161
H K G T +A + ++ S + GA
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Score = 52.0 bits (123), Expect = 2e-07
Identities = 36/124 (29%), Positives = 60/124 (48%), Gaps = 1/124 (0%)
Query: 42 LQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDN 101
L+ + GN + L G + + ++ G +H AA+ G + +Q LL + V+
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 102 EGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+GN LH+A+ G VV+ LVK A N+ ++ G T +A +VV + NGA
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGA-NINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154
Query: 162 GGAT 165
+T
Sbjct: 155 NQST 158
Score = 46.6 bits (109), Expect = 1e-05
Identities = 42/165 (25%), Positives = 71/165 (43%), Gaps = 20/165 (12%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLG----NPEIARRLLLRGANPD 64
LA A +G + + LL+N+ G+ L + + + + A LL N D
Sbjct: 167 LAVALQQGHNQAVAILLENDTK-------GKVRLPALHIAARKDDTKSAALLLQNDHNAD 219
Query: 65 LKDR--------TGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHL 116
++ + +GF +H AA G ++ LL A V+ G PLH+A+K G+
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 279
Query: 117 RVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+V+ L+ + + G T A G ++VV L+ GA
Sbjct: 280 NMVKLLLDR-GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323
Score = 42.0 bits (97), Expect = 2e-04
Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 14/161 (8%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDR 68
+AS A + ++ ++ N+N +QNGF + + + ++ + LL GAN
Sbjct: 103 IASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE-NHIDVVKYLLENGANQSTATE 161
Query: 69 TGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLP-LHLAAKEGHLRVVEFLVK--H 125
GF + A + G + LLE N + LP LH+AA++ + L++ H
Sbjct: 162 DGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDH 216
Query: 126 TAS-----NVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
A V G T +A YG V +L+ GA
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 257
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 75.9 bits (185), Expect = 2e-14
Identities = 46/157 (29%), Positives = 85/157 (54%), Gaps = 2/157 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G+L+++ L+ +++N N G AL + K G+ + + LL RG++ D + G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H A+ AG + ++ L++ A++N + G PL++AA+E H+ VV++L+++ A N
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA-NQ 156
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNL 167
G T +A G N+ V+++ N G L
Sbjct: 157 STATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRL 193
Score = 70.9 bits (172), Expect = 5e-13
Identities = 51/154 (33%), Positives = 76/154 (49%), Gaps = 2/154 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKD 67
L AA G +E + LL+N V+A+ +T L + +LG EI + LL A+PD
Sbjct: 468 LHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAAT 527
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
G+ +H +AR G +D LLE A ++ +G PLH+AAK G L V + L++ A
Sbjct: 528 TNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRA 587
Query: 128 SNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+ G T +A Y +V L+ GA
Sbjct: 588 A-ADSAGKNGLTPLHVAAHYDNQKVALLLLEKGA 620
Score = 69.7 bits (169), Expect = 1e-12
Identities = 48/151 (31%), Positives = 73/151 (48%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA G L+ LLQ ++ G T L V N ++A LL +GA+P + G
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H AA+ + TLL + A+ NI +G PLHLA++EGH +V L+ A N+
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA-NI 688
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
G T+ LA + V ++ +GA
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGA 719
Score = 67.0 bits (162), Expect = 7e-12
Identities = 49/151 (32%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 13 AARGD-LEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA+GD +E + LLQ+ V+ TAL V G+ + + LL + ANP+ + G
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG 398
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
F +H A + + ++ L+++ A + G P+H+AA GHL +V L+++ AS
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS-P 457
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
N +G+TA +A G+ EVV + NGA
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Score = 61.2 bits (147), Expect = 4e-10
Identities = 42/117 (35%), Positives = 58/117 (49%), Gaps = 1/117 (0%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G++ T LL V+ G T L V K GN + + LL RG D K R G
Sbjct: 240 AAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDG 299
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+H AAR+G ++ LLE A + G PLH+AA+ H+ V+ L++H A
Sbjct: 300 LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKA 356
Score = 59.7 bits (143), Expect = 1e-09
Identities = 42/151 (27%), Positives = 76/151 (50%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
A + ++ + L++ ++ A G T + V +G+ I LL GA+PD+ + G
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRG 464
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AARAG ++ ++ LL A V+ E PLH+A++ G +V+ L++H A +
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMA-HP 523
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
G T ++ G+ +V S++ GA
Sbjct: 524 DAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Score = 58.9 bits (141), Expect = 2e-09
Identities = 42/148 (28%), Positives = 71/148 (47%), Gaps = 4/148 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNP-EIARRLLLRGANPDLKDRTG 70
A+ G + +T LL N++ G T+L + + +A L GA+ D + G
Sbjct: 669 ASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLG 728
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS-N 129
+ + A G + + LL+ A+VN + G PLH AA++GH ++ L++H A N
Sbjct: 729 YTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPN 788
Query: 130 VGHRNHKGDTACDLARLYGRNEVVSLMQ 157
N G+TA +A+ G VV ++
Sbjct: 789 ATTAN--GNTALAIAKRLGYISVVDTLK 814
Score = 58.2 bits (139), Expect = 3e-09
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 2/139 (1%)
Query: 24 LLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGF 82
LL+ + +A G T L + K +IA LL GA ++ + G +H A++ G
Sbjct: 615 LLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGH 674
Query: 83 LDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACD 142
D + LL+ A++++ G LHLAA+E + V + L KH A H G T
Sbjct: 675 TDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH-TKLGYTPLI 733
Query: 143 LARLYGRNEVVSLMQANGA 161
+A YG ++V+ + GA
Sbjct: 734 VACHYGNVKMVNFLLKQGA 752
Score = 52.8 bits (125), Expect = 1e-07
Identities = 43/151 (28%), Positives = 73/151 (48%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKDRTG 70
A+ RG+ + LL ++A+ G T L + G+ ++ LL RGA + + G
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H AA+ ++ ++ LL+ +A V+ + LH+AA GH RV + L+ A N
Sbjct: 333 LSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA-NP 391
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
R G T +A R +V+ L+ GA
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGA 422
Score = 52.8 bits (125), Expect = 1e-07
Identities = 46/152 (30%), Positives = 72/152 (47%), Gaps = 4/152 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
A+ G E + LLQ+ + +A G T L + + G ++A LL GA L + G
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
F +H AA+ G LD + LL+ +A + G PLH+AA + +V L++ AS
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS-- 621
Query: 131 GHRNHK-GDTACDLARLYGRNEVVSLMQANGA 161
H K G T +A + ++ S + GA
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Score = 52.0 bits (123), Expect = 2e-07
Identities = 36/124 (29%), Positives = 60/124 (48%), Gaps = 1/124 (0%)
Query: 42 LQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDN 101
L+ + GN + L G + + ++ G +H AA+ G + +Q LL + V+
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATK 95
Query: 102 EGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+GN LH+A+ G VV+ LVK A N+ ++ G T +A +VV + NGA
Sbjct: 96 KGNTALHIASLAGQAEVVKVLVKEGA-NINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154
Query: 162 GGAT 165
+T
Sbjct: 155 NQST 158
Score = 46.6 bits (109), Expect = 1e-05
Identities = 42/165 (25%), Positives = 71/165 (43%), Gaps = 20/165 (12%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLG----NPEIARRLLLRGANPD 64
LA A +G + + LL+N+ G+ L + + + + A LL N D
Sbjct: 167 LAVALQQGHNQAVAILLENDTK-------GKVRLPALHIAARKDDTKSAALLLQNDHNAD 219
Query: 65 LKDR--------TGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHL 116
++ + +GF +H AA G ++ LL A V+ G PLH+A+K G+
Sbjct: 220 VQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNT 279
Query: 117 RVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+V+ L+ + + G T A G ++VV L+ GA
Sbjct: 280 NMVKLLLDR-GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA 323
Score = 42.0 bits (97), Expect = 2e-04
Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 14/161 (8%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDR 68
+AS A + ++ ++ N+N +QNGF + + + ++ + LL GAN
Sbjct: 103 IASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQE-NHIDVVKYLLENGANQSTATE 161
Query: 69 TGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLP-LHLAAKEGHLRVVEFLVK--H 125
GF + A + G + LLE N + LP LH+AA++ + L++ H
Sbjct: 162 DGFTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDH 216
Query: 126 TAS-----NVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
A V G T +A YG V +L+ GA
Sbjct: 217 NADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGA 257
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 75.9 bits (185), Expect = 2e-14
Identities = 54/159 (33%), Positives = 82/159 (51%), Gaps = 5/159 (3%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKD 67
L +AAA G +E + LL+ ++ N FG TAL + LG +A L+ GAN + +
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269
Query: 68 RTGFAVIHDAARA--GFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKH 125
GF +H AA + G L L+ L+ ADVN + EG PLH+AA G + L+++
Sbjct: 270 DKGFTPLHVAAVSTNGAL-CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN 328
Query: 126 TASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGA 164
S + + G+T +A YG ++S + NGA A
Sbjct: 329 -GSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTA 366
Score = 69.3 bits (168), Expect = 1e-12
Identities = 45/109 (41%), Positives = 61/109 (55%), Gaps = 5/109 (4%)
Query: 56 LLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNL---PLHLAAK 112
LL GA+P L+DR G+ +H AA G L+ LLE + +ED E + PLHLAA
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LEDVESTIPVSPLHLAAY 594
Query: 113 EGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
GH ++ L + T N+ R+HKG TA LA G E V ++ A+GA
Sbjct: 595 NGHCEALKTLAE-TLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGA 642
Score = 67.8 bits (164), Expect = 4e-12
Identities = 51/158 (32%), Positives = 81/158 (51%), Gaps = 2/158 (1%)
Query: 5 WGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNP-EIARRLLLRGANP 63
W L AAA + + L LL ++ +VNA++ +T L V + A L ++
Sbjct: 74 WLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSL 133
Query: 64 DLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLV 123
++ DR+G + +H A +G L+T+ LL A +N+ D + PLH AA GHL V++ LV
Sbjct: 134 NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLV 193
Query: 124 KHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
A ++G ++ KG A G+ EVV + GA
Sbjct: 194 ARGA-DLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGA 230
Score = 62.4 bits (150), Expect = 2e-10
Identities = 48/155 (30%), Positives = 77/155 (49%), Gaps = 3/155 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKD 67
L A G LE + LL ++N + R L LG+ E+ + L+ RGA+ KD
Sbjct: 144 LHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKD 203
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
R G+ ++H AA +G ++ ++ LL A+++ + GN LH+A G V LV +
Sbjct: 204 RKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV-NAG 262
Query: 128 SNVGHRNHKGDTACDLARLYGRNEV-VSLMQANGA 161
+NV N KG T +A + + + L+ NGA
Sbjct: 263 ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGA 297
Score = 60.5 bits (145), Expect = 7e-10
Identities = 52/155 (33%), Positives = 71/155 (45%), Gaps = 4/155 (2%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKD 67
L A D+E++ SLL N+N + RT L +G+ I + LL+ GAN + KD
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+H AA + L LL ADVN D PLH+AA + E L +
Sbjct: 72 TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLS 131
Query: 128 S-NVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
S NV R+ G +A A G E V+L+ GA
Sbjct: 132 SLNVADRS--GRSALHHAVHSGHLETVNLLLNKGA 164
Score = 53.5 bits (127), Expect = 8e-08
Identities = 48/143 (33%), Positives = 72/143 (50%), Gaps = 17/143 (11%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTAL-QVMKLGNPEIARRLLLRGANPDLKDR-T 69
AA G E L +L + VN++ ++ GRTAL + G+ E L GA+ +K+R
Sbjct: 592 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651
Query: 70 GFAVIHDAARAGFLDTLQTLLEF--QADV-NIEDNEGNLPLHLAAKEGHLRVVEFLVKHT 126
+ +H AA +G D+L L++ +AD+ ++ D G PL LA GH+ V L++
Sbjct: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLE-- 709
Query: 127 ASNVGHRNHKGDTACDLARLYGR 149
KG TA D A L GR
Sbjct: 710 ---------KGSTA-DAADLRGR 722
Score = 52.8 bits (125), Expect = 1e-07
Identities = 37/124 (29%), Positives = 59/124 (47%), Gaps = 4/124 (3%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVN---AQNGFGRTALQVMKL-GNPEIARRLLLRGANPD 64
L +AAA G + L L+ + + + +G+T L + + G+ + LL +G+ D
Sbjct: 656 LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTAD 715
Query: 65 LKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVK 124
D G +H A G D L LL+ A V D +G P+HLA+ GH V+ L++
Sbjct: 716 AADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQ 775
Query: 125 HTAS 128
S
Sbjct: 776 AALS 779
Score = 47.4 bits (111), Expect = 6e-06
Identities = 42/140 (30%), Positives = 57/140 (40%), Gaps = 7/140 (5%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLK-- 66
L +AA ++ L LLQ+ VNA + GRTAL A LL DL
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVL 921
Query: 67 DRTGFAVIHDAARAGFLDTLQTLLEFQAD---VNIEDNEGNLPLHLAAKEGHLRVVEFLV 123
D +H A G +L D +N ++ +PLH+AA+ G VV+ L+
Sbjct: 922 DENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALL 981
Query: 124 KH--TASNVGHRNHKGDTAC 141
H T V H AC
Sbjct: 982 SHGATVLAVDEEGHTPALAC 1001
Score = 45.8 bits (107), Expect = 2e-05
Identities = 38/134 (28%), Positives = 59/134 (44%), Gaps = 7/134 (5%)
Query: 40 TALQVMKLGNPEIARRLLLRGANPDL---KDRTGFAVIHDAARAGFLDTLQTLLEFQADV 96
T L + N + +LL + +D G +H AA A + L+ LL+ QA+V
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEV 884
Query: 97 NIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLM 156
N D+ G L AA+ G VEFL+ +++ + +TA LA G + ++
Sbjct: 885 NATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMI 944
Query: 157 QAN----GAGGATN 166
A G ATN
Sbjct: 945 LAETQDLGLINATN 958
Score = 43.1 bits (100), Expect = 1e-04
Identities = 42/173 (24%), Positives = 67/173 (38%), Gaps = 20/173 (11%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKD 67
L AA G + L+QN ++ + FG T L V + G+ + L+ GA+ +
Sbjct: 310 LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRG 369
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQA------------------DVNIEDNEGNLPLHL 109
+H A GF D + LL D+N DN G LH
Sbjct: 370 IHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429
Query: 110 AAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAG 162
AA G++ + L+ + +++ R+ G T A G + + GAG
Sbjct: 430 AASGGNVECLNLLLS-SGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAG 481
Score = 38.9 bits (89), Expect = 0.002
Identities = 40/146 (27%), Positives = 52/146 (35%), Gaps = 28/146 (19%)
Query: 2 AEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGF------------------------ 37
A+ +GN AAR E L S L N A+ G
Sbjct: 335 ADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSS 394
Query: 38 GRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVN 97
G+ V L N + L G + + D G +H AA G ++ L LL AD+
Sbjct: 395 GQLYSIVSSLSNEHV----LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLR 450
Query: 98 IEDNEGNLPLHLAAKEGHLRVVEFLV 123
D G PLH AA G + LV
Sbjct: 451 RRDKFGRTPLHYAAANGSYQCAVTLV 476
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 75.9 bits (185), Expect = 2e-14
Identities = 54/159 (33%), Positives = 83/159 (52%), Gaps = 5/159 (3%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDLKDRTG 70
A G LE LLQ+ NVN Q+ T L + G+ ++ R LL GA+ ++ G
Sbjct: 141 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVG 200
Query: 71 FAVIHDAARAGFLDTLQTLLE--FQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS 128
+H A+ GFL+ + L+E +ADVN +DNE ++PLH ++ GH +V++L++
Sbjct: 201 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLE 260
Query: 129 NVGH-RNHKGDTACDLARLYGRNEVV-SLMQANGAGGAT 165
H N GDT LA G+ EV ++Q +G T
Sbjct: 261 VQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT 299
Score = 70.5 bits (171), Expect = 7e-13
Identities = 43/147 (29%), Positives = 78/147 (53%), Gaps = 2/147 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDLKDRTG 70
A + + E +TSLL + ++ G TAL + + G+ E A LL GAN +++D
Sbjct: 108 AVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF 167
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKH-TASN 129
F +H AA G + LL+F ADVN+ G+ PLHLA+ +G L + + L++ + ++
Sbjct: 168 FTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 227
Query: 130 VGHRNHKGDTACDLARLYGRNEVVSLM 156
V ++++ +G +++V +
Sbjct: 228 VNAQDNEDHVPLHFCSRFGHHDIVKYL 254
Score = 58.2 bits (139), Expect = 3e-09
Identities = 40/134 (29%), Positives = 59/134 (44%), Gaps = 1/134 (0%)
Query: 28 NVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQ 87
N+N +NG L + G R L+L+G P R GF +H A + +
Sbjct: 59 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 118
Query: 88 TLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLY 147
+LL AD+ G LH+A GHL + L++H A NV ++ T +A Y
Sbjct: 119 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA-NVNIQDAVFFTPLHIAAYY 177
Query: 148 GRNEVVSLMQANGA 161
G +V L+ GA
Sbjct: 178 GHEQVTRLLLKFGA 191
Score = 38.9 bits (89), Expect = 0.002
Identities = 41/147 (27%), Positives = 68/147 (46%), Gaps = 15/147 (10%)
Query: 24 LLQNNVNVNAQ--NGFGRTALQVMKL-GNPEIARRLLLRGANPDLKDRTGFA--VIHDAA 78
LLQ+++ V N +G T L + G E+A+ ++ L F+ H A
Sbjct: 254 LLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSAC 313
Query: 79 RAG-FLDTLQTLLEFQA-DVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHK 136
G +D ++ LL+ ++N + +G+ LH A GH+R+V+FL+ + A
Sbjct: 314 TYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD-------M 366
Query: 137 GDTACDLARLYG-RNEVVSLMQANGAG 162
ACD +R G ++E LM A G
Sbjct: 367 NLVACDPSRSSGEKDEQTCLMWAYEKG 393
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 75.9 bits (185), Expect = 2e-14
Identities = 54/159 (33%), Positives = 83/159 (52%), Gaps = 5/159 (3%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDLKDRTG 70
A G LE LLQ+ NVN Q+ T L + G+ ++ R LL GA+ ++ G
Sbjct: 242 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVG 301
Query: 71 FAVIHDAARAGFLDTLQTLLE--FQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS 128
+H A+ GFL+ + L+E +ADVN +DNE ++PLH ++ GH +V++L++
Sbjct: 302 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLE 361
Query: 129 NVGH-RNHKGDTACDLARLYGRNEVV-SLMQANGAGGAT 165
H N GDT LA G+ EV ++Q +G T
Sbjct: 362 VQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT 400
Score = 70.5 bits (171), Expect = 7e-13
Identities = 43/147 (29%), Positives = 78/147 (53%), Gaps = 2/147 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDLKDRTG 70
A + + E +TSLL + ++ G TAL + + G+ E A LL GAN +++D
Sbjct: 209 AVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVF 268
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKH-TASN 129
F +H AA G + LL+F ADVN+ G+ PLHLA+ +G L + + L++ + ++
Sbjct: 269 FTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKAD 328
Query: 130 VGHRNHKGDTACDLARLYGRNEVVSLM 156
V ++++ +G +++V +
Sbjct: 329 VNAQDNEDHVPLHFCSRFGHHDIVKYL 355
Score = 58.2 bits (139), Expect = 3e-09
Identities = 40/134 (29%), Positives = 59/134 (44%), Gaps = 1/134 (0%)
Query: 28 NVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQ 87
N+N +NG L + G R L+L+G P R GF +H A + +
Sbjct: 160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELIT 219
Query: 88 TLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLY 147
+LL AD+ G LH+A GHL + L++H A NV ++ T +A Y
Sbjct: 220 SLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGA-NVNIQDAVFFTPLHIAAYY 278
Query: 148 GRNEVVSLMQANGA 161
G +V L+ GA
Sbjct: 279 GHEQVTRLLLKFGA 292
Score = 38.9 bits (89), Expect = 0.002
Identities = 41/147 (27%), Positives = 68/147 (46%), Gaps = 15/147 (10%)
Query: 24 LLQNNVNVNAQ--NGFGRTALQVMKL-GNPEIARRLLLRGANPDLKDRTGFA--VIHDAA 78
LLQ+++ V N +G T L + G E+A+ ++ L F+ H A
Sbjct: 355 LLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSAC 414
Query: 79 RAG-FLDTLQTLLEFQA-DVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHK 136
G +D ++ LL+ ++N + +G+ LH A GH+R+V+FL+ + A
Sbjct: 415 TYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGAD-------M 467
Query: 137 GDTACDLARLYG-RNEVVSLMQANGAG 162
ACD +R G ++E LM A G
Sbjct: 468 NLVACDPSRSSGEKDEQTCLMWAYEKG 494
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 75.9 bits (185), Expect = 2e-14
Identities = 55/160 (34%), Positives = 86/160 (53%), Gaps = 3/160 (1%)
Query: 4 PWGNELASAAARGDLEQLTSLLQNN-VNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGA 61
P N AA RG+L L LL + V+V+ ++ G T L V G+ + R L+L+GA
Sbjct: 11 PLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGA 70
Query: 62 NPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEF 121
+ +L+ +G + AA+ G D ++ L F A +G L A++ GH++VVE
Sbjct: 71 DINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVET 130
Query: 122 LVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
L+KH A N+ + + G TA LA G +V+ L+ A+GA
Sbjct: 131 LLKHGA-NIHDQLYDGATALFLAAQGGYLDVIRLLLASGA 169
Score = 55.1 bits (131), Expect = 3e-08
Identities = 39/135 (28%), Positives = 65/135 (48%), Gaps = 3/135 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G L+ + LL + VN G L + ++G+ E+ R +LLRGA+ D G
Sbjct: 152 AAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDG 211
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ AA G+ D ++ LL+F + I N G LH A G+++ V L++ ++
Sbjct: 212 TTALLKAANKGYNDVIKELLKFSPTLGILKN-GTSALHAAVLSGNIKTVALLLE-AGADP 269
Query: 131 GHRNHKGDTACDLAR 145
RN + +L +
Sbjct: 270 SLRNKANELPAELTK 284
Score = 52.8 bits (125), Expect = 1e-07
Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 1/116 (0%)
Query: 38 GRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVN 97
G L + G+ ++ LL GAN + G + AA+ G+LD ++ LL A VN
Sbjct: 113 GTALLAASQYGHMQVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVN 172
Query: 98 IEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVV 153
+G PL +A++ GH VV ++ A RN G TA A G N+V+
Sbjct: 173 QPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARN-DGTTALLKAANKGYNDVI 227
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 74.7 bits (182), Expect = 3e-14
Identities = 47/151 (31%), Positives = 76/151 (50%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDLKDRTG 70
AA G ++ + L + + + + F RTAL L G+ EI +LL GA D +DR
Sbjct: 155 AAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDRLD 214
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H A R G L+ ++ L AD N+ D + PLH+A + G + +VE + +
Sbjct: 215 CTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLS-LGLEI 273
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
R+ +GDTA A R +++ L+ +GA
Sbjct: 274 NARDREGDTALHDAVRLNRYKIIKLLLLHGA 304
Score = 39.3 bits (90), Expect = 0.002
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 2/99 (2%)
Query: 13 AARGDLEQLTSLLQNN-VNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKDRTG 70
A RG ++ LLQ++ + N ++ T L V ++ G EI L G + +DR G
Sbjct: 221 ACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREG 280
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHL 109
+HDA R ++ LL AD+ ++ G P L
Sbjct: 281 DTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDL 319
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 74.7 bits (182), Expect = 3e-14
Identities = 52/152 (34%), Positives = 83/152 (54%), Gaps = 4/152 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLG-NPEIARRLLLRGANPDLKDRTG 70
AA++G E LT LL N ++N++N G TAL + + P+ + LL GAN D D
Sbjct: 61 AASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANEDAVDAEN 120
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS-N 129
+ +H AA +G ++ L + +A +++ DN+G PL +A+ GH + L++ A N
Sbjct: 121 RSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVN 180
Query: 130 VGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
V +N K +A LA G EV L+ ++GA
Sbjct: 181 VTDKNDK--SALILACEKGSAEVAELLLSHGA 210
Score = 42.4 bits (98), Expect = 2e-04
Identities = 30/112 (26%), Positives = 52/112 (46%), Gaps = 1/112 (0%)
Query: 18 LEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNP-EIARRLLLRGANPDLKDRTGFAVIHD 76
++++ S V V N + L+ + G+ +A + A P D G + H
Sbjct: 1 MKRIFSCSSTQVAVERWNRHDQKLLEAVHRGDVGRVAALASRKSARPTKLDSNGQSPFHL 60
Query: 77 AARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS 128
AA G + L LL AD+N ++ +G+ LHLA + V+ L++H A+
Sbjct: 61 AASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGAN 112
Score = 30.4 bits (67), Expect = 0.75
Identities = 22/70 (31%), Positives = 33/70 (47%), Gaps = 1/70 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKD 67
L A+ G + LLQ VN + ++AL + + G+ E+A LL GA+ D
Sbjct: 157 LMIASLGGHAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVD 216
Query: 68 RTGFAVIHDA 77
TG +H A
Sbjct: 217 STGHDALHYA 226
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 74.3 bits (181), Expect = 5e-14
Identities = 50/118 (42%), Positives = 60/118 (50%), Gaps = 1/118 (0%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNP-EIARRLLLRGANPDLKDRTG 70
AA+ G E + +LL VNA N G T L N EIA LL GANPD KD
Sbjct: 80 AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS 128
+H AA G L + LL ++A NI+D EGN PLHLA E + + LV AS
Sbjct: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 197
Score = 35.4 bits (80), Expect = 0.023
Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 2/90 (2%)
Query: 73 VIHDAARAGFLDTL-QTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVG 131
++ + A +G L+ L +++L ++ D + LH A GH +VEFL++ V
Sbjct: 9 MVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ-LGVPVN 67
Query: 132 HRNHKGDTACDLARLYGRNEVVSLMQANGA 161
++ G + +A GR+E+V + GA
Sbjct: 68 DKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 74.3 bits (181), Expect = 5e-14
Identities = 52/154 (33%), Positives = 74/154 (48%), Gaps = 2/154 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKD 67
L A GD +++ +L+ +VN Q+ RT L LG+ EI L+L GA + KD
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+H A + + +Q LL+ ADVN D PLH+AA ++ E LV
Sbjct: 72 SKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVP-LL 130
Query: 128 SNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
SNV + G TA A G E+V L+ + GA
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGA 164
Score = 66.6 bits (161), Expect = 9e-12
Identities = 50/158 (31%), Positives = 80/158 (50%), Gaps = 2/158 (1%)
Query: 5 WGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANP 63
W L AAA ++ +L+ NVN + GRTAL G+ E+ + LL RGAN
Sbjct: 107 WQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANI 166
Query: 64 DLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLV 123
+ D+ IH AA G ++ ++ L+ A+V +D + PLH AA G + VV++L+
Sbjct: 167 NAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL 226
Query: 124 KHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
++ N G+T +A G++ VV+ + GA
Sbjct: 227 -DLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
Score = 66.6 bits (161), Expect = 9e-12
Identities = 51/153 (33%), Positives = 75/153 (49%), Gaps = 7/153 (4%)
Query: 11 SAAARGDLEQLTSLLQNNVNVNA---QNGFGRTALQVMKL-GNPEIARRLLLRGANPDLK 66
+AA G E L L+ N NA Q+G G+T L + L G+ + LL +GAN D K
Sbjct: 623 AAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAK 682
Query: 67 DRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHT 126
D+ G +H A G + + LL+ A + D+ G P+HL+A GH+ V+ L++
Sbjct: 683 DKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSA 742
Query: 127 AS---NVGHRNHKGDTACDLARLYGRNEVVSLM 156
AS N ++ G TA A G V L+
Sbjct: 743 ASMDANPATADNHGYTALHWACYNGHETCVELL 775
Score = 55.1 bits (131), Expect = 3e-08
Identities = 41/121 (33%), Positives = 58/121 (47%), Gaps = 5/121 (4%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTAL-QVMKLGNPEIARRLLLRGANPDLKD 67
L + G + + SLL NV+A++ +GRTAL + G+ E LL GA L+D
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIE----DNEGNLPLHLAAKEGHLRVVEFLV 123
G IH +A G + L LL+ A ++ DN G LH A GH VE L+
Sbjct: 717 SRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLL 776
Query: 124 K 124
+
Sbjct: 777 E 777
Score = 54.3 bits (129), Expect = 5e-08
Identities = 46/147 (31%), Positives = 70/147 (47%), Gaps = 3/147 (2%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLG-NPEIARRLLLRGANPDLKDRTG 70
AA G + LL + +++ + FGRT L G N E LL GA+ + KD+ G
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAA-KEGHLRVVEFLVKHTASN 129
+ +H AA L L+ A VN D G PLH AA + + +E+L+++ A N
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA-N 497
Query: 130 VGHRNHKGDTACDLARLYGRNEVVSLM 156
G R+ +G A + YG + L+
Sbjct: 498 PGIRDKQGYNAVHYSAAYGHRLCLQLI 524
Score = 52.4 bits (124), Expect = 2e-07
Identities = 43/187 (22%), Positives = 76/187 (40%), Gaps = 36/187 (19%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLL---------- 58
L +AA+ G + + LL V++N N +G T L V ++ L+
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269
Query: 59 -------------------------RGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQ 93
GA+ ++K + G +H A G QT+++
Sbjct: 270 EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSG 329
Query: 94 ADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVV 153
A ++ ED GN PLH+AA+ GH ++ L+ + ++ R G LA L G ++
Sbjct: 330 AVIDCEDKNGNTPLHIAARYGHELLINTLIT-SGADTAKRGIHGMFPLHLAALSGFSDCC 388
Query: 154 SLMQANG 160
+ ++G
Sbjct: 389 RKLLSSG 395
Score = 50.1 bits (118), Expect = 9e-07
Identities = 42/175 (24%), Positives = 70/175 (40%), Gaps = 34/175 (19%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKD 67
L AA G E + LL N+NA + R A+ +G+ E+ + L+ GA KD
Sbjct: 144 LHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLA----------------- 110
+ + +H AA +G + ++ LL+ D+N + GN PLH+A
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
Query: 111 ----------------AKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGR 149
A H + L+ ++V ++ G T + L+GR
Sbjct: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGR 318
Score = 47.4 bits (111), Expect = 6e-06
Identities = 43/125 (34%), Positives = 56/125 (44%), Gaps = 2/125 (1%)
Query: 6 GNELASAAARGDLEQLTSLLQNNVNVNAQNGF-GRTALQVMKL-GNPEIARRLLLRGANP 63
GN AAR E L + L + A+ G G L + L G + R+LL G +
Sbjct: 339 GNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDI 398
Query: 64 DLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLV 123
D D G +H AA G L+ L LL AD N +D G PLH AA + + + LV
Sbjct: 399 DTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALV 458
Query: 124 KHTAS 128
AS
Sbjct: 459 GSGAS 463
Score = 43.1 bits (100), Expect = 1e-04
Identities = 42/165 (25%), Positives = 70/165 (42%), Gaps = 17/165 (10%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQ----NGFGRTALQVMKLGNPEIARRLLLRGANPDLKD 67
+AA G + L +LLQ+ +++A + G TAL E LLL +
Sbjct: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE 785
Query: 68 RTGFAVIH-------DAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVE 120
F+ +H + A +DTL + VN D++G PLH AA H+ ++
Sbjct: 786 GNAFSPLHCAVINDNEGAAEMLIDTLGASI-----VNATDSKGRTPLHAAAFTDHVECLQ 840
Query: 121 FLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGAT 165
L+ H A V + G T +A G+ V ++ ++ + T
Sbjct: 841 LLLSHNA-QVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELT 884
Score = 43.1 bits (100), Expect = 1e-04
Identities = 45/150 (30%), Positives = 65/150 (43%), Gaps = 5/150 (3%)
Query: 16 GDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDLKDRTGFAVI 74
G E L L ++ VNA + GRT L + E + LL A + D TG +
Sbjct: 802 GAAEMLIDTLGASI-VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPL 860
Query: 75 HDAARAGFLDTLQTLLEF-QADVNIEDNEGNLPLHLAAKEGH-LRVVEFLVKHTASN-VG 131
AA G +T++ L+ A++ ++DN N LHLA +GH + L K T N +
Sbjct: 861 MMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLIN 920
Query: 132 HRNHKGDTACDLARLYGRNEVVSLMQANGA 161
N T +A G VV + GA
Sbjct: 921 ATNAALQTPLHVAARNGLTMVVQELLGKGA 950
Score = 42.4 bits (98), Expect = 2e-04
Identities = 27/96 (28%), Positives = 46/96 (47%)
Query: 64 DLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLV 123
D +R + +H AA G L+ L++ D+++ ++ G PL LAA +GH+ V+ L+
Sbjct: 544 DSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLI 603
Query: 124 KHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQAN 159
AS + T A G +E + L+ N
Sbjct: 604 NQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN 639
Score = 40.0 bits (92), Expect = 0.001
Identities = 35/125 (28%), Positives = 57/125 (45%), Gaps = 5/125 (4%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPD--LK 66
L +AA +E L LL +N VN+ + G+T L + +L+ A+ + L+
Sbjct: 827 LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQ 886
Query: 67 DRTGFAVIHDAARAGFLDTLQTLLEFQAD---VNIEDNEGNLPLHLAAKEGHLRVVEFLV 123
D + +H A G + +LE D +N + PLH+AA+ G VV+ L+
Sbjct: 887 DNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELL 946
Query: 124 KHTAS 128
AS
Sbjct: 947 GKGAS 951
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 73.2 bits (178), Expect = 1e-13
Identities = 53/154 (34%), Positives = 77/154 (50%), Gaps = 4/154 (2%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKD 67
L AA G E LLQN VNA+ +T L ++G+ + + LL ANP+L
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
G +H AAR G ++T+ LLE +A +G PLH+AAK G +RV E L++ A
Sbjct: 534 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 593
Query: 128 -SNVGHRNHKGDTACDLARLYGRNEVVSLMQANG 160
N +N G T +A + ++V L+ G
Sbjct: 594 HPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRG 625
Score = 68.9 bits (167), Expect = 2e-12
Identities = 48/147 (32%), Positives = 72/147 (48%), Gaps = 2/147 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKDRTG 70
AA G E + LL N N N G T L V + G+ +A L+ G D R G
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H A+ G + ++ LL+ QADVN + G PLH AA++GH +V L+K+ AS
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS-P 793
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQ 157
+ G T +A+ G V +++
Sbjct: 794 NEVSSDGTTPLAIAKRLGYISVTDVLK 820
Score = 66.6 bits (161), Expect = 9e-12
Identities = 48/157 (30%), Positives = 80/157 (50%), Gaps = 2/157 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G+L++ L+N V++N N G L + K G+ ++ LL + + + G
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AA AG + ++ L+ + A+VN + +G PL++AA+E HL VV+FL+++ A N
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA-NQ 170
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNL 167
G T +A G VV+ + G G L
Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL 207
Score = 64.3 bits (155), Expect = 5e-11
Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 2/143 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
A + + + LL+ +++A G T L V +G+ I + LL RGA+P++ +
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AARAG + + LL+ +A VN + + PLH AA+ GH +V+ L+++ A N
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA-NP 529
Query: 131 GHRNHKGDTACDLARLYGRNEVV 153
G T +A G E V
Sbjct: 530 NLATTAGHTPLHIAAREGHVETV 552
Score = 63.2 bits (152), Expect = 1e-10
Identities = 37/120 (30%), Positives = 63/120 (52%), Gaps = 1/120 (0%)
Query: 7 NELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDL 65
N L A+ G ++ + LL + + G TAL + L G E+ R L+ GAN +
Sbjct: 80 NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 139
Query: 66 KDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKH 125
+ + GF ++ AA+ L+ ++ LLE A+ N+ +G PL +A ++GH VV L+ +
Sbjct: 140 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 199
Score = 61.6 bits (148), Expect = 3e-10
Identities = 44/146 (30%), Positives = 70/146 (47%), Gaps = 2/146 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
A +L+ + LL + ++ G T L + K E+AR LL G + + + G
Sbjct: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AA+ G + + LL QA+ N+ + G PLHL A+EGH+ V + L+KH V
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM-V 727
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLM 156
G T +A YG ++V +
Sbjct: 728 DATTRMGYTPLHVASHYGNIKLVKFL 753
Score = 60.8 bits (146), Expect = 5e-10
Identities = 38/117 (32%), Positives = 60/117 (51%), Gaps = 1/117 (0%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA D LLQN+ N + + G T L + N +A+ LL RGA+ + + G
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 272
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+H A+R G + ++ LL+ A + + + PLH AA+ GH+R+ E L+ H A
Sbjct: 273 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 329
Score = 58.9 bits (141), Expect = 2e-09
Identities = 48/152 (31%), Positives = 77/152 (50%), Gaps = 5/152 (3%)
Query: 13 AARGD-LEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA+GD L+ + LLQ + ++ T L V G+ +A+ LL +GA P+ + G
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS-N 129
F +H A + + ++ LL+ A ++ G PLH+A+ GHL +V+ L++ AS N
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
Query: 130 VGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
V N K +T +A G EV + N A
Sbjct: 465 VS--NVKVETPLHMAARAGHTEVAKYLLQNKA 494
Score = 58.5 bits (140), Expect = 3e-09
Identities = 49/162 (30%), Positives = 72/162 (44%), Gaps = 3/162 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKD 67
L AA G + LL+NN N N G T L + + G+ E LL + A+
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+ GF +H AA+ G + + LLE A N G PLH+A +L +V+ L+
Sbjct: 567 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 626
Query: 128 SNVGHRNHKGDTACDLARLYGRNEVV-SLMQANGAGGATNLQ 168
S G T +A + EV SL+Q G+ A ++Q
Sbjct: 627 SPHSPA-WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 667
Score = 51.6 bits (122), Expect = 3e-07
Identities = 34/101 (33%), Positives = 52/101 (51%), Gaps = 3/101 (2%)
Query: 28 NVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTL 86
+VN QNG T L + + GN + R LL RGA + K + +H AAR G +
Sbjct: 264 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 321
Query: 87 QTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+ LL+ A + + G P+H+AA+ HL V L+++ A
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 362
Score = 51.6 bits (122), Expect = 3e-07
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKDRTG 70
A+ RG++ + LL + + T L + G+ I+ LL GA K + G
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ IH AA+ LD ++ LL++ A+++ + PLH+AA GH RV + L+ A
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA-KP 397
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
R G T +A V+ L+ GA
Sbjct: 398 NSRALNGFTPLHIACKKNHVRVMELLLKTGA 428
Score = 48.9 bits (115), Expect = 2e-06
Identities = 45/154 (29%), Positives = 65/154 (42%), Gaps = 6/154 (3%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKD 67
L AA LE + LL+N N N G T L V ++ G+ + L+ G K
Sbjct: 148 LYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KG 203
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+ +H AAR T LL+ + ++ G PLH+AA +L V + L+ A
Sbjct: 204 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 263
Query: 128 SNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
S V G T +A G +V L+ GA
Sbjct: 264 S-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 296
Score = 47.4 bits (111), Expect = 6e-06
Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 1/120 (0%)
Query: 42 LQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDN 101
L+ + GN + A L G + + ++ G +H A++ G + + LL + +
Sbjct: 50 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 109
Query: 102 EGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+GN LH+AA G VV LV + A NV ++ KG T +A EVV + NGA
Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 168
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 73.2 bits (178), Expect = 1e-13
Identities = 53/154 (34%), Positives = 77/154 (50%), Gaps = 4/154 (2%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKD 67
L AA G E LLQN VNA+ +T L ++G+ + + LL ANP+L
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
G +H AAR G ++T+ LLE +A +G PLH+AAK G +RV E L++ A
Sbjct: 501 TAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560
Query: 128 -SNVGHRNHKGDTACDLARLYGRNEVVSLMQANG 160
N +N G T +A + ++V L+ G
Sbjct: 561 HPNAAGKN--GLTPLHVAVHHNNLDIVKLLLPRG 592
Score = 68.9 bits (167), Expect = 2e-12
Identities = 48/147 (32%), Positives = 72/147 (48%), Gaps = 2/147 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKDRTG 70
AA G E + LL N N N G T L V + G+ +A L+ G D R G
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ +H A+ G + ++ LL+ QADVN + G PLH AA++GH +V L+K+ AS
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGAS-P 760
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQ 157
+ G T +A+ G V +++
Sbjct: 761 NEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 66.6 bits (161), Expect = 9e-12
Identities = 48/157 (30%), Positives = 80/157 (50%), Gaps = 2/157 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
AA G+L++ L+N V++N N G L + K G+ ++ LL + + + G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AA AG + ++ L+ + A+VN + +G PL++AA+E HL VV+FL+++ A N
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA-NQ 137
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNL 167
G T +A G VV+ + G G L
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL 174
Score = 64.3 bits (155), Expect = 5e-11
Identities = 44/143 (30%), Positives = 72/143 (50%), Gaps = 2/143 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
A + + + LL+ +++A G T L V +G+ I + LL RGA+P++ +
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AARAG + + LL+ +A VN + + PLH AA+ GH +V+ L+++ A N
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA-NP 496
Query: 131 GHRNHKGDTACDLARLYGRNEVV 153
G T +A G E V
Sbjct: 497 NLATTAGHTPLHIAAREGHVETV 519
Score = 63.2 bits (152), Expect = 1e-10
Identities = 37/120 (30%), Positives = 63/120 (52%), Gaps = 1/120 (0%)
Query: 7 NELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKL-GNPEIARRLLLRGANPDL 65
N L A+ G ++ + LL + + G TAL + L G E+ R L+ GAN +
Sbjct: 47 NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
Query: 66 KDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKH 125
+ + GF ++ AA+ L+ ++ LLE A+ N+ +G PL +A ++GH VV L+ +
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Score = 61.6 bits (148), Expect = 3e-10
Identities = 44/146 (30%), Positives = 70/146 (47%), Gaps = 2/146 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTG 70
A +L+ + LL + ++ G T L + K E+AR LL G + + + G
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+H AA+ G + + LL QA+ N+ + G PLHL A+EGH+ V + L+KH V
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM-V 694
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLM 156
G T +A YG ++V +
Sbjct: 695 DATTRMGYTPLHVASHYGNIKLVKFL 720
Score = 60.8 bits (146), Expect = 5e-10
Identities = 38/117 (32%), Positives = 60/117 (51%), Gaps = 1/117 (0%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA D LLQN+ N + + G T L + N +A+ LL RGA+ + + G
Sbjct: 180 AARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNG 239
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+H A+R G + ++ LL+ A + + + PLH AA+ GH+R+ E L+ H A
Sbjct: 240 ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGA 296
Score = 58.9 bits (141), Expect = 2e-09
Identities = 48/152 (31%), Positives = 77/152 (50%), Gaps = 5/152 (3%)
Query: 13 AARGD-LEQLTSLLQNNVNVNAQNGFGRTALQVMK-LGNPEIARRLLLRGANPDLKDRTG 70
AA+GD L+ + LLQ + ++ T L V G+ +A+ LL +GA P+ + G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTAS-N 129
F +H A + + ++ LL+ A ++ G PLH+A+ GHL +V+ L++ AS N
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 130 VGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
V N K +T +A G EV + N A
Sbjct: 432 VS--NVKVETPLHMAARAGHTEVAKYLLQNKA 461
Score = 58.5 bits (140), Expect = 3e-09
Identities = 49/162 (30%), Positives = 72/162 (44%), Gaps = 3/162 (1%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKD 67
L AA G + LL+NN N N G T L + + G+ E LL + A+
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+ GF +H AA+ G + + LLE A N G PLH+A +L +V+ L+
Sbjct: 534 KKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 593
Query: 128 SNVGHRNHKGDTACDLARLYGRNEVV-SLMQANGAGGATNLQ 168
S G T +A + EV SL+Q G+ A ++Q
Sbjct: 594 SPHSPA-WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQ 634
Score = 51.6 bits (122), Expect = 3e-07
Identities = 34/101 (33%), Positives = 52/101 (51%), Gaps = 3/101 (2%)
Query: 28 NVNVNAQNGFGRTALQVM-KLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTL 86
+VN QNG T L + + GN + R LL RGA + K + +H AAR G +
Sbjct: 231 SVNFTPQNGI--TPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 87 QTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+ LL+ A + + G P+H+AA+ HL V L+++ A
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDA 329
Score = 51.6 bits (122), Expect = 3e-07
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 2/151 (1%)
Query: 12 AAARGDLEQLTSLLQNNVNVNAQNGFGRTALQ-VMKLGNPEIARRLLLRGANPDLKDRTG 70
A+ RG++ + LL + + T L + G+ I+ LL GA K + G
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305
Query: 71 FAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNV 130
+ IH AA+ LD ++ LL++ A+++ + PLH+AA GH RV + L+ A
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGA-KP 364
Query: 131 GHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
R G T +A V+ L+ GA
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKTGA 395
Score = 48.9 bits (115), Expect = 2e-06
Identities = 45/154 (29%), Positives = 65/154 (42%), Gaps = 6/154 (3%)
Query: 9 LASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV-MKLGNPEIARRLLLRGANPDLKD 67
L AA LE + LL+N N N G T L V ++ G+ + L+ G K
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KG 170
Query: 68 RTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTA 127
+ +H AAR T LL+ + ++ G PLH+AA +L V + L+ A
Sbjct: 171 KVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGA 230
Query: 128 SNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
S V G T +A G +V L+ GA
Sbjct: 231 S-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGA 263
Score = 47.4 bits (111), Expect = 6e-06
Identities = 36/120 (30%), Positives = 57/120 (47%), Gaps = 1/120 (0%)
Query: 42 LQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDN 101
L+ + GN + A L G + + ++ G +H A++ G + + LL + +
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 102 EGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGA 161
+GN LH+AA G VV LV + A NV ++ KG T +A EVV + NGA
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGA-NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,669,232
Number of Sequences: 37866
Number of extensions: 209736
Number of successful extensions: 2488
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 330
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 444
Number of HSP's gapped (non-prelim): 1220
length of query: 168
length of database: 18,247,518
effective HSP length: 95
effective length of query: 73
effective length of database: 14,650,248
effective search space: 1069468104
effective search space used: 1069468104
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.