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Search of human proteins with 4502601
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502601 carbonyl reductase 3 [Homo sapiens]
(277 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502601 carbonyl reductase 3 [Homo sapiens] 555 e-158
gi|4502599 carbonyl reductase 1 [Homo sapiens] 406 e-113
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo... 62 4e-10
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 62 5e-10
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 62 7e-10
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 60 2e-09
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom... 57 1e-08
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 54 1e-07
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 54 2e-07
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo... 52 7e-07
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 51 1e-06
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 50 2e-06
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 50 2e-06
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 50 2e-06
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 49 5e-06
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 47 2e-05
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 47 2e-05
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 47 2e-05
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 45 9e-05
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 44 2e-04
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s... 44 2e-04
gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo... 44 2e-04
gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo ... 44 2e-04
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 44 2e-04
gi|40254992 carbonic reductase 4 [Homo sapiens] 43 3e-04
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 43 3e-04
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 43 3e-04
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 42 8e-04
gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens] 41 0.001
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 41 0.001
>gi|4502601 carbonyl reductase 3 [Homo sapiens]
Length = 277
Score = 555 bits (1431), Expect = e-158
Identities = 277/277 (100%), Positives = 277/277 (100%)
Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60
MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH
Sbjct: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60
Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120
QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN
Sbjct: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120
Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180
MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK
Sbjct: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180
Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240
NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS
Sbjct: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240
Query: 241 IRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 277
IRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW
Sbjct: 241 IRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 277
>gi|4502599 carbonyl reductase 1 [Homo sapiens]
Length = 277
Score = 406 bits (1043), Expect = e-113
Identities = 199/277 (71%), Positives = 235/277 (84%)
Query: 1 MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH 60
MSS VALVTG N+GIGLAI R+LCR FSGDVVLTARDV RGQAAVQQLQAEGLSPRFH
Sbjct: 1 MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH 60
Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRN 120
QLDIDDLQSIRALRDFLRKEYGGL+VLVNNA +AFK DP PF I+AE+T+KTNFF TR+
Sbjct: 61 QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD 120
Query: 121 MCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180
+C ELLP++KP GRVVN+SS+ +RA ++CS +LQ++F SET+TE +LV LM KFVEDTK
Sbjct: 121 VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK 180
Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS 240
VH++EGWP+S YGV+K+GVTVLSRI AR+L E+RK D+IL+NACCPG V+TDM G +
Sbjct: 181 KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA 240
Query: 241 IRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW 277
++ EEGAETPVYLALLPPDA P GQ V +K V+ W
Sbjct: 241 TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW 277
>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
sapiens]
Length = 336
Score = 62.4 bits (150), Expect = 4e-10
Identities = 77/291 (26%), Positives = 119/291 (40%), Gaps = 79/291 (27%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE-------GLSPR 58
+ L+TGAN G+G A A EL R V++ RD AR + A QL+ E G P
Sbjct: 44 KTVLITGANSGLGRATAAELLR-LGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102
Query: 59 F--------HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAV----AFKSDDPMPFDIK 106
+LD+ L+S+RA + +E L+VL+NNA + K++D
Sbjct: 103 VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGF----- 157
Query: 107 AEMTLKTNFFATRNMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLT 164
EM N + N LL ++K R+V +SS
Sbjct: 158 -EMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSS------------------------ 192
Query: 165 EGDLVDLMKKFVEDTKNEVHEREGWPNS-PYGVSKLGVTVLSRILARRLDEKRKADRILV 223
+ K+ + ++++ + + S Y SKL + +R LARRL+ + V
Sbjct: 193 ------KLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLE----GTNVTV 242
Query: 224 NACCPGPVKTDMDGKDSI----------------RTVEEGAETPVYLALLP 258
N PG V+T++ I +T EGA+T +YLA P
Sbjct: 243 NVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSP 293
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 62.0 bits (149), Expect = 5e-10
Identities = 72/275 (26%), Positives = 122/275 (44%), Gaps = 51/275 (18%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH--QLD 63
+ +VTGAN GIG A EL R+ G+++L RD+ + +AA + ++ E L+ + LD
Sbjct: 39 KTVIVTGANTGIGKQTALELARR-GGNIILACRDMEKCEAAAKDIRGETLNHHVNARHLD 97
Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVA----FKSDDPMPFDIKAEMTLKTNFFATR 119
+ L+SIR + +E +++L+NNA V + ++D EM N
Sbjct: 98 LASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGF------EMQFGVNHLGHF 151
Query: 120 NMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVE 177
+ N LL +K R++N+SSL + + DL +K+
Sbjct: 152 LLTNLLLDKLKASAPSRIINLSSLAHVAGH---------------IDFDDLNWQTRKY-- 194
Query: 178 DTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDG 237
+TK + Y SKL + + ++ L+RRL + + VNA PG +T++
Sbjct: 195 NTK-----------AAYCQSKLAIVLFTKELSRRL----QGSGVTVNALHPGVARTELGR 239
Query: 238 KDSIR--TVEEGAETPVYLALL--PPDATEPQGQL 268
I T P++ L+ P A +P L
Sbjct: 240 HTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTYL 274
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 61.6 bits (148), Expect = 7e-10
Identities = 67/266 (25%), Positives = 113/266 (42%), Gaps = 50/266 (18%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRF--HQLD 63
+V ++TGAN GIG AREL + V + RDV +G++A +++ + + + +LD
Sbjct: 40 KVVVITGANTGIGKETARELASR-GARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLD 98
Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLK-TNFFATRNMC 122
+ D +SIRA + E L++L+NNA V + + + F +
Sbjct: 99 LSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLL 158
Query: 123 NELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNE 182
E L + P RVVN+SS+ + K D ++E
Sbjct: 159 LERLKVSAP-ARVVNVSSV--------------------------AHHIGKIPFHDLQSE 191
Query: 183 VHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDS-- 240
G+ Y SKL + +R LA+RL + + A PG V++++ S
Sbjct: 192 KRYSRGF---AYCHSKLANVLFTRELAKRL----QGTGVTTYAVHPGVVRSELVRHSSLL 244
Query: 241 ----------IRTVEEGAETPVYLAL 256
++T EGA+T ++ AL
Sbjct: 245 CLLWRLFSPFVKTAREGAQTSLHCAL 270
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 60.5 bits (145), Expect = 2e-09
Identities = 72/270 (26%), Positives = 115/270 (42%), Gaps = 58/270 (21%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRF--HQLD 63
+V +VTGAN GIG A+EL ++ V L RDV +G+ +++Q + + +LD
Sbjct: 42 KVVVVTGANTGIGKETAKELAQR-GARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA---EMTLKTNFFATRN 120
+ D +SIRA E L+VL+NNA V P+ A EM + N
Sbjct: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAGVMM-----CPYSKTADGFEMHIGVNHLGHFL 155
Query: 121 MCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178
+ + LL +K R+VN+SSL + E+F++ L
Sbjct: 156 LTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLA-------------- 201
Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238
Y SKL + ++ LARRL K + + PG V++++
Sbjct: 202 ---------------YCHSKLANILFTQELARRL----KGSGVTTYSVHPGTVQSELVRH 242
Query: 239 DS------------IRTVEEGAETPVYLAL 256
S I+T ++GA+T ++ AL
Sbjct: 243 SSFMRWMWWLFSFFIKTPQQGAQTSLHCAL 272
>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
sapiens]
Length = 377
Score = 57.4 bits (137), Expect = 1e-08
Identities = 74/273 (27%), Positives = 107/273 (39%), Gaps = 61/273 (22%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPR--FHQLD 63
R A+VTGAN GIG A EL R+ VVL R RG+AA L+ E + F LD
Sbjct: 37 RTAVVTGANSGIGKMTALELARR-GARVVLACRSQERGEAAAFDLRQESGNNEVIFMALD 95
Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123
+ L S+RA L++L++NA ++ F+ + L+ N + +
Sbjct: 96 LASLASVRAFATAFLSSEPRLDILIHNAGISSCGRTREAFN----LLLRVNHIGPFLLTH 151
Query: 124 ELLPIMK---PHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180
LLP +K P VV S+ C G L D K
Sbjct: 152 LLLPCLKACAPSRVVVVASAAHC---------------------RGRL---------DFK 181
Query: 181 NEVHEREGWPNS--PYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGK 238
GW Y +KL + +R LA +L+ A + A PGPV +++ +
Sbjct: 182 RLDRPVVGWRQELRAYADTKLANVLFARELANQLE----ATGVTCYAAHPGPVNSELFLR 237
Query: 239 D---------------SIRTVEEGAETPVYLAL 256
+R GA+TP+Y AL
Sbjct: 238 HVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCAL 270
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 53.9 bits (128), Expect = 1e-07
Identities = 50/142 (35%), Positives = 70/142 (49%), Gaps = 8/142 (5%)
Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64
++VALVT + GIG AIAR L Q VV+++R AV LQ EGLS +
Sbjct: 32 NKVALVTASTDGIGFAIARRLA-QDRAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHV 90
Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEM---TLKTNFFATRNM 121
+ L K +GG+++LV+NAAV M D+ E+ TL N A M
Sbjct: 91 GKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLM--DVTEEVWDKTLDINVKAPALM 148
Query: 122 CNELLPIMKPH--GRVVNISSL 141
++P M+ G VV +SS+
Sbjct: 149 TKAVVPEMEKRGGGSVVIVSSI 170
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 53.5 bits (127), Expect = 2e-07
Identities = 50/142 (35%), Positives = 70/142 (49%), Gaps = 8/142 (5%)
Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64
++VALVT + GIG AIAR L Q VV+++R AV LQ EGLS +
Sbjct: 32 NKVALVTASTDGIGFAIARRLA-QDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHV 90
Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEM---TLKTNFFATRNM 121
+ L K +GG+++LV+NAAV M D+ E+ TL N A M
Sbjct: 91 GKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIM--DVTEEVWDKTLDINVKAPALM 148
Query: 122 CNELLPIMKPH--GRVVNISSL 141
++P M+ G VV +SS+
Sbjct: 149 TKAVVPEMEKRGGGSVVIVSSI 170
>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
sapiens]
Length = 330
Score = 51.6 bits (122), Expect = 7e-07
Identities = 68/276 (24%), Positives = 111/276 (40%), Gaps = 58/276 (21%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65
RVA+VTG GIG + A+ L R V++ + ++ + V +++ E L+ + L
Sbjct: 44 RVAIVTGGTDGIGYSTAKHLAR-LGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFL-YC 101
Query: 66 DLQSIRALRDFLRK---EYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122
DL S+ ++R F++K + L+VL+NNA V + L N+ +
Sbjct: 102 DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGL--NYLGHFLLT 159
Query: 123 NELLPIMKPHG------RVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFV 176
N LL +K G RVV +SS + + E ++ DL
Sbjct: 160 NLLLDTLKESGSPGHSARVVTVSSA------------------THYVAELNMDDLQSSAC 201
Query: 177 EDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD-- 234
P++ Y SKL + + + L R L + + N PG V TD
Sbjct: 202 YS-----------PHAAYAQSKLALVLFTYHLQRLL--AAEGSHVTANVVDPGVVNTDVY 248
Query: 235 ------------MDGKDSIRTVEEGAETPVYLALLP 258
+ G +T +EGA T +Y A+ P
Sbjct: 249 KHVFWATRLAKKLLGWLLFKTPDEGAWTSIYAAVTP 284
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 50.8 bits (120), Expect = 1e-06
Identities = 62/264 (23%), Positives = 111/264 (42%), Gaps = 54/264 (20%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRF------ 59
R+ALVTGA+ GIG A+AR L +Q VV AR V +++L AE S +
Sbjct: 12 RLALVTGASGGIGAAVARALVQQ-GLKVVGCARTVGN----IEELAAECKSAGYPGTLIP 66
Query: 60 HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATR 119
++ D+ + + I ++ +R ++ G+++ +NNA +A + + L + +
Sbjct: 67 YRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLA-----------RPDTLLSGSTSGWK 115
Query: 120 NMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDT 179
+M N VN+ +L C+ + + + +G ++++
Sbjct: 116 DMFN------------VNVLALSI------CTREAYQSMKERNVDDGHIINI-------- 149
Query: 180 KNEVHEREGWPNSP---YGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMD 236
N + P S Y +K VT L+ L + L E + I PG V+T
Sbjct: 150 -NSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQ--THIRATCISPGVVETQFA 206
Query: 237 GKDSIRTVEEGAETPVYLALLPPD 260
K + E+ A T + L P+
Sbjct: 207 FKLHDKDPEKAAATYEQMKCLKPE 230
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 50.4 bits (119), Expect = 2e-06
Identities = 40/143 (27%), Positives = 63/143 (44%), Gaps = 7/143 (4%)
Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQ 61
S + L+TGA GIG A E + S L D+ + + +GL + H
Sbjct: 33 SVTGEIVLITGAGHGIGRLTAYEFAKLKSK---LVLWDINKHGLEETAAKCKGLGAKVHT 89
Query: 62 LDID--DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATR 119
+D + + I + ++ E G +++LVNNA V + SD D + E T + N A
Sbjct: 90 FVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHF 149
Query: 120 NMCNELLPIM--KPHGRVVNISS 140
LP M HG +V ++S
Sbjct: 150 WTTKAFLPAMTKNNHGHIVTVAS 172
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 50.1 bits (118), Expect = 2e-06
Identities = 42/167 (25%), Positives = 75/167 (44%), Gaps = 12/167 (7%)
Query: 9 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQ 68
L+TG RGIG +ARE + + +VL R + ++++ G + D+ + +
Sbjct: 42 LITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNRE 101
Query: 69 SIRALRDFLRKEYGGLNVLVNNAAVA-----FKSDDPMPFDIKAEMTLKTNFFATRNMCN 123
+ +R++ G + +LVNNAAV SDD + TL F+ T+
Sbjct: 102 EVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTL-GQFWTTKAFLP 160
Query: 124 ELLPIMKPHGRVVNISSLQCLR----AFENCSEDLQERFHSETLTEG 166
+L + +G +V ++S+ L A + C+ E+LT G
Sbjct: 161 RMLELQ--NGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLG 205
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 50.1 bits (118), Expect = 2e-06
Identities = 46/141 (32%), Positives = 66/141 (46%), Gaps = 10/141 (7%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH----- 60
+VA+VTG GIG AI +EL + +VV+ +R + R ++A +LQA L P
Sbjct: 19 QVAIVTGGATGIGKAIVKELL-ELGSNVVIASRKLERLKSAADELQA-NLPPTKQARVIP 76
Query: 61 -QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATR 119
Q +I + + + L +G +N LVNN F S L+TN T
Sbjct: 77 IQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTF 136
Query: 120 NMCNELLPI-MKPH-GRVVNI 138
MC + MK H G +VNI
Sbjct: 137 YMCKAVYSSWMKEHGGSIVNI 157
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 48.9 bits (115), Expect = 5e-06
Identities = 37/146 (25%), Positives = 68/146 (46%), Gaps = 11/146 (7%)
Query: 2 SSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE----GLSP 57
S + L+TGA GIG E ++ S +L D+ + V++ AE G++
Sbjct: 33 SVAGEIVLITGAGHGIGRQTTYEFAKRQS---ILVLWDI--NKRGVEETAAECRKLGVTA 87
Query: 58 RFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFA 117
+ +D + + I + ++KE G + ++VNNA + +D D + T + N
Sbjct: 88 HAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILG 147
Query: 118 TRNMCNELLPIM--KPHGRVVNISSL 141
+ LLP M + HG +V ++S+
Sbjct: 148 HFWITKALLPSMMERNHGHIVTVASV 173
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 47.0 bits (110), Expect = 2e-05
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 3/139 (2%)
Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64
+RVA+VTG+ GIG AIAR L R VV+++R A+ +LQ EGLS +
Sbjct: 36 NRVAVVTGSTSGIGFAIARRLARD-GAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHV 94
Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA-EMTLKTNFFATRNMCN 123
+ L + GG++ LV +A V + + + L N + + +
Sbjct: 95 GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
Query: 124 ELLPIMK-PHGRVVNISSL 141
+LLP M+ G V+ +SS+
Sbjct: 155 QLLPYMENRRGAVILVSSI 173
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 47.0 bits (110), Expect = 2e-05
Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 3/139 (2%)
Query: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDI 64
+RVA+VTG+ GIG AIAR L R VV+++R A+ +LQ EGLS +
Sbjct: 36 NRVAVVTGSTSGIGFAIARRLARD-GAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHV 94
Query: 65 DDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA-EMTLKTNFFATRNMCN 123
+ L + GG++ LV +A V + + + L N + + +
Sbjct: 95 GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
Query: 124 ELLPIMK-PHGRVVNISSL 141
+LLP M+ G V+ +SS+
Sbjct: 155 QLLPYMENRRGAVILVSSI 173
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 46.6 bits (109), Expect = 2e-05
Identities = 40/138 (28%), Positives = 59/138 (42%), Gaps = 7/138 (5%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65
+V +VTG RGIG I R VV+ +D + G+A Q+L F D+
Sbjct: 10 KVVVVTGGGRGIGAGIVRAFVNS-GARVVICDKDESGGRALEQELP----GAVFILCDVT 64
Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKA-EMTLKTNFFATRNMCNE 124
++ L + +G L+ +VNNA P + L+ N T +
Sbjct: 65 QEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKL 124
Query: 125 LLP-IMKPHGRVVNISSL 141
LP + K G V+NISSL
Sbjct: 125 ALPYLRKSQGNVINISSL 142
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 44.7 bits (104), Expect = 9e-05
Identities = 43/169 (25%), Positives = 70/169 (41%), Gaps = 8/169 (4%)
Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVAR-GQAAVQQLQAEGLSPRFHQL--D 63
+ L+TGA G+G +A + R S VL D+ + G ++ E + R H D
Sbjct: 42 IVLITGAGSGLGRLLALQFARLGS---VLVLWDINKEGNEETCKMAREAGATRVHAYTCD 98
Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCN 123
+ + + D ++KE G +++L+NNA + D E + NF A
Sbjct: 99 CSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYK 158
Query: 124 ELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVD 170
LP M HG +V ISS L ++ +F + E V+
Sbjct: 159 AFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVE 207
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 43.9 bits (102), Expect = 2e-04
Identities = 38/147 (25%), Positives = 70/147 (47%), Gaps = 15/147 (10%)
Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLS------PRFH 60
V ++TGA G+G A+ +VL R+ + +++L A + P
Sbjct: 54 VVVITGATSGLGKECAKVFYAA-GAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLV 112
Query: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKS---DDPMPFDIKAEMTLKTNFFA 117
D+ D +I A + + +G +++LVNNA ++++ D + D + ++TN+F
Sbjct: 113 TFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVD---KRVMETNYFG 169
Query: 118 TRNMCNELLP--IMKPHGRVVNISSLQ 142
+ LLP I + G +V ISS+Q
Sbjct: 170 PVALTKALLPSMIKRRQGHIVAISSIQ 196
>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
sapiens]
Length = 414
Score = 43.5 bits (101), Expect = 2e-04
Identities = 66/273 (24%), Positives = 105/273 (38%), Gaps = 51/273 (18%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFH--QLD 63
+V +VTGAN GIG A+ V+L R++AR AV ++ E + LD
Sbjct: 125 KVVVVTGANSGIGFETAKSFALH-GAHVILACRNMARASEAVSRILEEWHKAKVEAMTLD 183
Query: 64 IDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIK---AEMTLKTNFFATRN 120
+ L+S++ + + + L+VLV NAA +P+ + E T + N
Sbjct: 184 LALLRSVQHFAEAFKAKNVPLHVLVCNAATF-----ALPWSLTKDGLETTFQVNHLGHFY 238
Query: 121 MCNELLPIM--KPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVED 178
+ L ++ RV+ +SS H T L L +
Sbjct: 239 LVQLLQDVLCRSAPARVIVVSS----------------ESHRFTDINDSLGKLDFSRLSP 282
Query: 179 TKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTD---- 234
TKN+ W Y SKL + S L RRL + + NA PG +
Sbjct: 283 TKNDY-----WAMLAYNRSKLCNILFSNELHRRLSPR----GVTSNAVHPGNMMYSNIHR 333
Query: 235 ---------MDGKDSIRTVEEGAETPVYLALLP 258
+ +++++GA T VY A +P
Sbjct: 334 SWWVYTLLFTLARPFTKSMQQGAATTVYCAAVP 366
>gi|209862901 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 43.5 bits (101), Expect = 2e-04
Identities = 31/87 (35%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65
+V +VTGA+RGIG IA +LC+ V +T R + + Q+ Q+ G D
Sbjct: 8 QVCVVTGASRGIGRGIALQLCKA-GATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSS 66
Query: 66 DLQSIRALRDFL-RKEYGGLNVLVNNA 91
+R+L + + R++ G L+VLVNNA
Sbjct: 67 QESEVRSLFEQVDREQQGRLDVLVNNA 93
>gi|19923983 dehydrogenase/reductase (SDR family) member 1 [Homo
sapiens]
Length = 313
Score = 43.5 bits (101), Expect = 2e-04
Identities = 31/87 (35%), Positives = 48/87 (55%), Gaps = 2/87 (2%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65
+V +VTGA+RGIG IA +LC+ V +T R + + Q+ Q+ G D
Sbjct: 8 QVCVVTGASRGIGRGIALQLCKA-GATVYITGRHLDTLRVVAQEAQSLGGQCVPVVCDSS 66
Query: 66 DLQSIRALRDFL-RKEYGGLNVLVNNA 91
+R+L + + R++ G L+VLVNNA
Sbjct: 67 QESEVRSLFEQVDREQQGRLDVLVNNA 93
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 43.5 bits (101), Expect = 2e-04
Identities = 35/139 (25%), Positives = 67/139 (48%), Gaps = 10/139 (7%)
Query: 10 VTGANRGIGLAIARELCRQFSGDVVLTARD-------VARGQAAVQQLQAEGLSPRFHQL 62
+TGA+RGIG AIA + + ++V+ A+ + A ++++A G +
Sbjct: 15 ITGASRGIGKAIALKAAKD-GANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGKALPCIV 73
Query: 63 DIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMC 122
D+ D Q I A + K++GG+++LVNNA+ ++ + ++ + N T
Sbjct: 74 DVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTRGTYLAS 133
Query: 123 NELLPIMKPH--GRVVNIS 139
+P +K ++NIS
Sbjct: 134 KACIPYLKKSKVAHILNIS 152
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 43.1 bits (100), Expect = 3e-04
Identities = 57/235 (24%), Positives = 89/235 (37%), Gaps = 57/235 (24%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65
+V V G +RGIG A+A+ + R+ + + AR++ +AA L + L+ D+
Sbjct: 3 KVCAVFGGSRGIGRAVAQLMARK-GYRLAVIARNLEGAKAAAGDLGGDHLA---FSCDVA 58
Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAE---MTLKTNFFATRNMC 122
++ + L K G +N LVN A + + D + K E L TN + C
Sbjct: 59 KEHDVQNTFEELEKHLGRVNFLVNAAGI---NRDGLLVRTKTEDMVSQLHTNLLGSMLTC 115
Query: 123 NELL--PIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTK 180
+ I + G +VN+ S+ L+
Sbjct: 116 KAAMRTMIQQQGGSIVNVGSIVGLKGNSG------------------------------- 144
Query: 181 NEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDM 235
S Y SK G+ SR LA+ + K +I VN PG V TDM
Sbjct: 145 ----------QSVYSASKGGLVGFSRALAKEVARK----KIRVNVVAPGFVHTDM 185
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform
2 [Homo sapiens]
Length = 178
Score = 42.7 bits (99), Expect = 3e-04
Identities = 38/94 (40%), Positives = 50/94 (53%), Gaps = 11/94 (11%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARG---QAAVQQLQAEGLSPRFHQL 62
+VALVTGA +GIG A A L + V L ++ G +AA+ + Q E F Q
Sbjct: 6 KVALVTGAAQGIGRAFAEALLLK-GAKVALVDWNLEAGVQCKAALDE-QFEPQKTLFIQC 63
Query: 63 DIDDLQSIRALRDFLRK---EYGGLNVLVNNAAV 93
D+ D Q LRD RK +G L++LVNNA V
Sbjct: 64 DVADQQQ---LRDTFRKVVDHFGRLDILVNNAGV 94
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 42.7 bits (99), Expect = 3e-04
Identities = 38/94 (40%), Positives = 50/94 (53%), Gaps = 11/94 (11%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARG---QAAVQQLQAEGLSPRFHQL 62
+VALVTGA +GIG A A L + V L ++ G +AA+ + Q E F Q
Sbjct: 6 KVALVTGAAQGIGRAFAEALLLK-GAKVALVDWNLEAGVQCKAALDE-QFEPQKTLFIQC 63
Query: 63 DIDDLQSIRALRDFLRK---EYGGLNVLVNNAAV 93
D+ D Q LRD RK +G L++LVNNA V
Sbjct: 64 DVADQQQ---LRDTFRKVVDHFGRLDILVNNAGV 94
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 41.6 bits (96), Expect = 8e-04
Identities = 42/151 (27%), Positives = 65/151 (43%), Gaps = 6/151 (3%)
Query: 7 VALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRF-HQLDID 65
+ L TGA G+G +A R F +VL + + + +G F + D
Sbjct: 38 IVLTTGAGSGLGRQLAIYFAR-FGAILVLWDVNQEGNMETCRLAKEKGGKKVFPYTCDCS 96
Query: 66 DLQSIRALRDFLRKEYGGLNVLVNNA-AVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNE 124
+ Q + + D +RKE+G + +LVNNA V K +P D E + N C
Sbjct: 97 NRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIP-DHMVEKSFLVNAITHFWTCKA 155
Query: 125 LLP--IMKPHGRVVNISSLQCLRAFENCSED 153
LP I HG +V ISS+ + S++
Sbjct: 156 FLPAVIKANHGHLVCISSIAGVVGINGLSDE 186
>gi|4504503 hydroxysteroid (17-beta) dehydrogenase 2 [Homo sapiens]
Length = 387
Score = 41.2 bits (95), Expect = 0.001
Identities = 40/143 (27%), Positives = 66/143 (46%), Gaps = 12/143 (8%)
Query: 6 RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDID 65
+ LVTG + G+G A+ + L G V G A + + SPR L +D
Sbjct: 83 KAVLVTGGDCGLGHALCKYLDEL--GFTVFAGVLNENGPGAEELRRT--CSPRLSVLQMD 138
Query: 66 DLQSIRALRDFLRK-----EYGGLNVLVNNAAV-AFKSDDPMPFDIKAEMTLKTNFFATR 119
+ ++ ++D K + GL ++NNA V F +D + + + NFF T
Sbjct: 139 ITKPVQ-IKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTV 197
Query: 120 NMCNELLPIM-KPHGRVVNISSL 141
+ LP++ K GR+VN+SS+
Sbjct: 198 EVTKTFLPLLRKSKGRLVNVSSM 220
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 40.8 bits (94), Expect = 0.001
Identities = 42/132 (31%), Positives = 55/132 (41%), Gaps = 7/132 (5%)
Query: 7 VALVTGANRGIGLAIARELCRQFSGD--VVLTARDV---ARGQAAVQQLQAEGLSPRFHQ 61
V L+TG + GIGL +A L S V T RD+ R A + L S Q
Sbjct: 5 VVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQ 64
Query: 62 LDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNM 121
LD+ D +S+ A R+ R G ++VLV NA + + L N T M
Sbjct: 65 LDVRDSKSVAAARE--RVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRM 122
Query: 122 CNELLPIMKPHG 133
LP MK G
Sbjct: 123 LQAFLPDMKRRG 134
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,214,093
Number of Sequences: 37866
Number of extensions: 452279
Number of successful extensions: 1174
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 1117
Number of HSP's gapped (non-prelim): 83
length of query: 277
length of database: 18,247,518
effective HSP length: 101
effective length of query: 176
effective length of database: 14,423,052
effective search space: 2538457152
effective search space used: 2538457152
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.