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Search of human proteins with 4502023
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502023 AKT2 kinase [Homo sapiens]
(481 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502023 AKT2 kinase [Homo sapiens] 984 0.0
gi|62241015 AKT1 kinase [Homo sapiens] 822 0.0
gi|62241013 AKT1 kinase [Homo sapiens] 822 0.0
gi|62241011 AKT1 kinase [Homo sapiens] 822 0.0
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens] 773 0.0
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens] 744 0.0
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph... 338 8e-93
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta... 338 8e-93
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 333 2e-91
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H... 329 3e-90
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [... 329 3e-90
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [... 329 3e-90
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [... 329 3e-90
gi|5453974 protein kinase N2 [Homo sapiens] 327 2e-89
gi|28557781 protein kinase C, eta [Homo sapiens] 326 3e-89
gi|133908623 protein kinase C, iota [Homo sapiens] 325 4e-89
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 324 1e-88
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 324 1e-88
gi|4885563 protein kinase C, epsilon [Homo sapiens] 322 6e-88
gi|4506067 protein kinase C, alpha [Homo sapiens] 320 2e-87
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 316 3e-86
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens] 314 1e-85
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens] 314 1e-85
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens] 312 4e-85
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens] 312 4e-85
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens] 312 4e-85
gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Ho... 306 4e-83
gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [H... 304 1e-82
gi|13384594 protein kinase C, gamma [Homo sapiens] 302 5e-82
gi|5453976 protein kinase C, theta [Homo sapiens] 300 2e-81
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 984 bits (2543), Expect = 0.0
Identities = 481/481 (100%), Positives = 481/481 (100%)
Query: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC 60
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
Sbjct: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC 60
Query: 61 QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM 120
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
Sbjct: 61 QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM 120
Query: 121 DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM 180
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
Sbjct: 121 DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM 180
Query: 181 KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH 240
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
Sbjct: 181 KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH 240
Query: 241 LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG 300
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
Sbjct: 241 LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG 300
Query: 301 ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE 360
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
Sbjct: 301 ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE 360
Query: 361 LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK 420
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
Sbjct: 361 LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK 420
Query: 421 KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR 480
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
Sbjct: 421 KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR 480
Query: 481 E 481
E
Sbjct: 481 E 481
>gi|62241015 AKT1 kinase [Homo sapiens]
Length = 480
Score = 822 bits (2123), Expect = 0.0
Identities = 391/479 (81%), Positives = 443/479 (92%), Gaps = 3/479 (0%)
Query: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC 60
M++V+++KEGWLHKRGEYIKTWRPRYFLLK+DG+FIGYKERP+ DQ PLNNFSVA+C
Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
Query: 61 QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM 120
QLMKTERPRPNTF+IRCLQWTTVIERTFHV++P+EREEW AIQ VA+ LK++ E+ M
Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQE--EEEM 118
Query: 121 DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM 180
D++ GSPSD+S EEMEV+++K + +VTMN+F+YLKLLGKGTFGKVILV+EKATGRYYAM
Sbjct: 119 DFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
Query: 181 KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH 240
KIL+KEVI+AKDEVAHT+TE+RVLQN+RHPFLTALKY+FQTHDRLCFVMEYANGGELFFH
Sbjct: 179 KILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 238
Query: 241 LSRERVFTEERARFYGAEIVSALEYLHS-RDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
LSRERVF+E+RARFYGAEIVSAL+YLHS ++VVYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298
Query: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
GI DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 299 GIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 358
Query: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
ELILMEEIRFPRTL PEAKSLL+GLLKKDPKQRLGGG DAKE+M+HRFF I WQ V +
Sbjct: 359 ELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 418
Query: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSAS 478
KKL PPFKPQVTSE DTRYFD+EFTAQ ITITPPD+ DS+ ++ ++R HFPQFSYSAS
Sbjct: 419 KKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477
>gi|62241013 AKT1 kinase [Homo sapiens]
Length = 480
Score = 822 bits (2123), Expect = 0.0
Identities = 391/479 (81%), Positives = 443/479 (92%), Gaps = 3/479 (0%)
Query: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC 60
M++V+++KEGWLHKRGEYIKTWRPRYFLLK+DG+FIGYKERP+ DQ PLNNFSVA+C
Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
Query: 61 QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM 120
QLMKTERPRPNTF+IRCLQWTTVIERTFHV++P+EREEW AIQ VA+ LK++ E+ M
Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQE--EEEM 118
Query: 121 DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM 180
D++ GSPSD+S EEMEV+++K + +VTMN+F+YLKLLGKGTFGKVILV+EKATGRYYAM
Sbjct: 119 DFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
Query: 181 KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH 240
KIL+KEVI+AKDEVAHT+TE+RVLQN+RHPFLTALKY+FQTHDRLCFVMEYANGGELFFH
Sbjct: 179 KILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 238
Query: 241 LSRERVFTEERARFYGAEIVSALEYLHS-RDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
LSRERVF+E+RARFYGAEIVSAL+YLHS ++VVYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298
Query: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
GI DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 299 GIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 358
Query: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
ELILMEEIRFPRTL PEAKSLL+GLLKKDPKQRLGGG DAKE+M+HRFF I WQ V +
Sbjct: 359 ELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 418
Query: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSAS 478
KKL PPFKPQVTSE DTRYFD+EFTAQ ITITPPD+ DS+ ++ ++R HFPQFSYSAS
Sbjct: 419 KKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477
>gi|62241011 AKT1 kinase [Homo sapiens]
Length = 480
Score = 822 bits (2123), Expect = 0.0
Identities = 391/479 (81%), Positives = 443/479 (92%), Gaps = 3/479 (0%)
Query: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC 60
M++V+++KEGWLHKRGEYIKTWRPRYFLLK+DG+FIGYKERP+ DQ PLNNFSVA+C
Sbjct: 1 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC 60
Query: 61 QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM 120
QLMKTERPRPNTF+IRCLQWTTVIERTFHV++P+EREEW AIQ VA+ LK++ E+ M
Sbjct: 61 QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQE--EEEM 118
Query: 121 DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM 180
D++ GSPSD+S EEMEV+++K + +VTMN+F+YLKLLGKGTFGKVILV+EKATGRYYAM
Sbjct: 119 DFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAM 178
Query: 181 KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH 240
KIL+KEVI+AKDEVAHT+TE+RVLQN+RHPFLTALKY+FQTHDRLCFVMEYANGGELFFH
Sbjct: 179 KILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFH 238
Query: 241 LSRERVFTEERARFYGAEIVSALEYLHS-RDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
LSRERVF+E+RARFYGAEIVSAL+YLHS ++VVYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 239 LSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE 298
Query: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
GI DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 299 GIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 358
Query: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
ELILMEEIRFPRTL PEAKSLL+GLLKKDPKQRLGGG DAKE+M+HRFF I WQ V +
Sbjct: 359 ELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYE 418
Query: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSAS 478
KKL PPFKPQVTSE DTRYFD+EFTAQ ITITPPD+ DS+ ++ ++R HFPQFSYSAS
Sbjct: 419 KKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSAS 477
>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
Length = 479
Score = 773 bits (1995), Expect = 0.0
Identities = 374/484 (77%), Positives = 430/484 (88%), Gaps = 8/484 (1%)
Query: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLP-PLNNFSVAE 59
M++V+++KEGW+ KRGEYIK WRPRYFLLK+DGSFIGYKE+P+ D LP PLNNFSVA+
Sbjct: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQ--DVDLPYPLNNFSVAK 58
Query: 60 CQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDP 119
CQLMKTERP+PNTF+IRCLQWTTVIERTFHVD+P+EREEW AIQ VA+ L+++ E+
Sbjct: 59 CQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQE--EER 116
Query: 120 MDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYA 179
M+ S D+ EEM+ + + + K TMNDFDYLKLLGKGTFGKVILVREKA+G+YYA
Sbjct: 117 MNCSPTSQIDNIGEEEMDASTTHHKRK-TMNDFDYLKLLGKGTFGKVILVREKASGKYYA 175
Query: 180 MKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFF 239
MKIL+KEVIIAKDEVAHT+TESRVL+NTRHPFLT+LKY+FQT DRLCFVMEY NGGELFF
Sbjct: 176 MKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
Query: 240 HLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
HLSRERVF+E+R RFYGAEIVSAL+YLHS +VYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
Query: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
GI+D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
Query: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
ELILME+I+FPRTLS +AKSLL+GLL KDP +RLGGGP DAKE+M H FF +NWQDV
Sbjct: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
Query: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGL--LELDQRTHFPQFSYSA 477
KKL+PPFKPQVTSE DTRYFD+EFTAQ+ITITPP++YD G+ ++ ++R HFPQFSYSA
Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSA 475
Query: 478 SIRE 481
S RE
Sbjct: 476 SGRE 479
>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
Length = 465
Score = 744 bits (1922), Expect = 0.0
Identities = 358/456 (78%), Positives = 409/456 (89%), Gaps = 6/456 (1%)
Query: 1 MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLP-PLNNFSVAE 59
M++V+++KEGW+ KRGEYIK WRPRYFLLK+DGSFIGYKE+P+ D LP PLNNFSVA+
Sbjct: 1 MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQ--DVDLPYPLNNFSVAK 58
Query: 60 CQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDP 119
CQLMKTERP+PNTF+IRCLQWTTVIERTFHVD+P+EREEW AIQ VA+ L+++ E+
Sbjct: 59 CQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQE--EER 116
Query: 120 MDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYA 179
M+ S D+ EEM+ + + + K TMNDFDYLKLLGKGTFGKVILVREKA+G+YYA
Sbjct: 117 MNCSPTSQIDNIGEEEMDASTTHHKRK-TMNDFDYLKLLGKGTFGKVILVREKASGKYYA 175
Query: 180 MKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFF 239
MKIL+KEVIIAKDEVAHT+TESRVL+NTRHPFLT+LKY+FQT DRLCFVMEY NGGELFF
Sbjct: 176 MKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFF 235
Query: 240 HLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
HLSRERVF+E+R RFYGAEIVSAL+YLHS +VYRD+KLENLMLDKDGHIKITDFGLCKE
Sbjct: 236 HLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKE 295
Query: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
GI+D ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE+LF
Sbjct: 296 GITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLF 355
Query: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
ELILME+I+FPRTLS +AKSLL+GLL KDP +RLGGGP DAKE+M H FF +NWQDV
Sbjct: 356 ELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYD 415
Query: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDR 455
KKL+PPFKPQVTSE DTRYFD+EFTAQ+ITITPP++
Sbjct: 416 KKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEK 451
>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
[Homo sapiens]
Length = 367
Score = 338 bits (866), Expect = 8e-93
Identities = 164/325 (50%), Positives = 220/325 (67%), Gaps = 3/325 (0%)
Query: 126 SPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRK 185
SP S + + S A DFD+LK++GKG +GKV+L + K+ G +YA+K+L+K
Sbjct: 10 SPQPSRANGNINLGPS-ANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQK 68
Query: 186 EVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRE 244
+ I+ K E +H + E VL +N RHPFL L+Y+FQT ++L FV++Y NGGELFFHL RE
Sbjct: 69 KSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRE 128
Query: 245 RVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDG 304
R F E RARFY AE+ SA+ YLHS +++YRD+K EN++LD GH+ +TDFGLCKEG+
Sbjct: 129 RRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPE 188
Query: 305 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILM 364
T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD +++E IL
Sbjct: 189 DTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH 248
Query: 365 EEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLP 424
+ ++ P + A LL LL KD +QRL G +D E+ H FF INW D+ K+L P
Sbjct: 249 QPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTP 307
Query: 425 PFKPQVTSEVDTRYFDDEFTAQSIT 449
PF P VT D ++FD EFT ++++
Sbjct: 308 PFNPNVTGPADLKHFDPEFTQEAVS 332
>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
[Homo sapiens]
Length = 427
Score = 338 bits (866), Expect = 8e-93
Identities = 164/325 (50%), Positives = 220/325 (67%), Gaps = 3/325 (0%)
Query: 126 SPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRK 185
SP S + + S A DFD+LK++GKG +GKV+L + K+ G +YA+K+L+K
Sbjct: 70 SPQPSRANGNINLGPS-ANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQK 128
Query: 186 EVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRE 244
+ I+ K E +H + E VL +N RHPFL L+Y+FQT ++L FV++Y NGGELFFHL RE
Sbjct: 129 KSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRE 188
Query: 245 RVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDG 304
R F E RARFY AE+ SA+ YLHS +++YRD+K EN++LD GH+ +TDFGLCKEG+
Sbjct: 189 RRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPE 248
Query: 305 ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILM 364
T TFCGTPEYLAPEVL Y RAVDWW LG V+YEM+ G PFY+QD +++E IL
Sbjct: 249 DTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILH 308
Query: 365 EEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLP 424
+ ++ P + A LL LL KD +QRL G +D E+ H FF INW D+ K+L P
Sbjct: 309 QPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFFSPINWDDLYHKRLTP 367
Query: 425 PFKPQVTSEVDTRYFDDEFTAQSIT 449
PF P VT D ++FD EFT ++++
Sbjct: 368 PFNPNVTGPADLKHFDPEFTQEAVS 392
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 333 bits (855), Expect = 2e-91
Identities = 160/351 (45%), Positives = 233/351 (66%), Gaps = 5/351 (1%)
Query: 127 PSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKE 186
P + +T + + R ++ + DF++L +LGKG+FGKV+L K T YA+KIL+K+
Sbjct: 317 PEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD 376
Query: 187 VIIAKDEVAHTVTESRVLQNT-RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRER 245
V+I D+V T+ E RVL + PFLT L FQT DRL FVMEY NGG+L +H+ +
Sbjct: 377 VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG 436
Query: 246 VFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGA 305
F E A FY AEI L +L S+ ++YRD+KL+N+MLD +GHIKI DFG+CKE I DG
Sbjct: 437 RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV 496
Query: 306 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILME 365
T KTFCGTP+Y+APE++ YG++VDWW GV++YEM+ G+ PF +D + LF+ I+
Sbjct: 497 TTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 556
Query: 366 EIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPP 425
+ +P+++S EA ++ GL+ K P +RLG GP +++ EH FF I+W+ + +K++ PP
Sbjct: 557 NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 616
Query: 426 FKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYS 476
+KP+ + DT FD EFT Q + +TP D+ L ++ LDQ F FSY+
Sbjct: 617 YKPKARDKRDTSNFDKEFTRQPVELTPTDK---LFIMNLDQ-NEFAGFSYT 663
>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
sapiens]
Length = 431
Score = 329 bits (844), Expect = 3e-90
Identities = 168/344 (48%), Positives = 225/344 (65%), Gaps = 4/344 (1%)
Query: 106 VANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGK 165
V + LK P E + SP S + + S AK + DF +LK++GKG+FGK
Sbjct: 54 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 111
Query: 166 VILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDR 224
V+L R KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L ++FQT D+
Sbjct: 112 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 171
Query: 225 LCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD 284
L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS ++VYRD+K EN++LD
Sbjct: 172 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 231
Query: 285 KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 344
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 232 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 291
Query: 345 CGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
G PFY+++ +++ IL + ++ ++ A+ LL GLL+KD +RL G D E+
Sbjct: 292 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 350
Query: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI 448
H FF INW D++ KK+ PPF P V+ D R+FD EFT + +
Sbjct: 351 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 394
>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
[Homo sapiens]
Length = 445
Score = 329 bits (844), Expect = 3e-90
Identities = 168/344 (48%), Positives = 225/344 (65%), Gaps = 4/344 (1%)
Query: 106 VANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGK 165
V + LK P E + SP S + + S AK + DF +LK++GKG+FGK
Sbjct: 68 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 125
Query: 166 VILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDR 224
V+L R KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L ++FQT D+
Sbjct: 126 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 185
Query: 225 LCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD 284
L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS ++VYRD+K EN++LD
Sbjct: 186 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 245
Query: 285 KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 344
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 246 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 305
Query: 345 CGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
G PFY+++ +++ IL + ++ ++ A+ LL GLL+KD +RL G D E+
Sbjct: 306 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 364
Query: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI 448
H FF INW D++ KK+ PPF P V+ D R+FD EFT + +
Sbjct: 365 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 408
>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
[Homo sapiens]
Length = 459
Score = 329 bits (844), Expect = 3e-90
Identities = 168/344 (48%), Positives = 225/344 (65%), Gaps = 4/344 (1%)
Query: 106 VANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGK 165
V + LK P E + SP S + + S AK + DF +LK++GKG+FGK
Sbjct: 82 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 139
Query: 166 VILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDR 224
V+L R KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L ++FQT D+
Sbjct: 140 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 199
Query: 225 LCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD 284
L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS ++VYRD+K EN++LD
Sbjct: 200 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 259
Query: 285 KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 344
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 260 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 319
Query: 345 CGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
G PFY+++ +++ IL + ++ ++ A+ LL GLL+KD +RL G D E+
Sbjct: 320 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 378
Query: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI 448
H FF INW D++ KK+ PPF P V+ D R+FD EFT + +
Sbjct: 379 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 422
>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
[Homo sapiens]
Length = 526
Score = 329 bits (844), Expect = 3e-90
Identities = 168/344 (48%), Positives = 225/344 (65%), Gaps = 4/344 (1%)
Query: 106 VANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGK 165
V + LK P E + SP S + + S AK + DF +LK++GKG+FGK
Sbjct: 149 VQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPS--DFHFLKVIGKGSFGK 206
Query: 166 VILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDR 224
V+L R KA +YA+K+L+K+ I+ K E H ++E VL +N +HPFL L ++FQT D+
Sbjct: 207 VLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADK 266
Query: 225 LCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD 284
L FV++Y NGGELF+HL RER F E RARFY AEI SAL YLHS ++VYRD+K EN++LD
Sbjct: 267 LYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLD 326
Query: 285 KDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMM 344
GHI +TDFGLCKE I +T TFCGTPEYLAPEVL Y R VDWW LG V+YEM+
Sbjct: 327 SQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEML 386
Query: 345 CGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVM 404
G PFY+++ +++ IL + ++ ++ A+ LL GLL+KD +RL G D E+
Sbjct: 387 YGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRL-GAKDDFMEIK 445
Query: 405 EHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI 448
H FF INW D++ KK+ PPF P V+ D R+FD EFT + +
Sbjct: 446 SHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPV 489
>gi|5453974 protein kinase N2 [Homo sapiens]
Length = 984
Score = 327 bits (837), Expect = 2e-89
Identities = 172/394 (43%), Positives = 245/394 (62%), Gaps = 14/394 (3%)
Query: 90 VDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDS---STTEEMEVAVSKARAK 146
+D P + E + IQ NS+ ++ E YK +P S +E+E S+ R +
Sbjct: 596 LDIPGQDSETVFDIQNDRNSILPKSQSE----YKPDTPQSGLEYSGIQELEDRRSQQRFQ 651
Query: 147 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ- 205
+ DF +LG+G FGKV+L K T +A+K L+K I+A+DEV + E R+ +
Sbjct: 652 FNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMCEKRIFET 711
Query: 206 --NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSAL 263
+ RHPFL L FQT + +CFVMEYA GG+L H+ + VF+E RA FY A +V L
Sbjct: 712 VNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD-VFSEPRAVFYAACVVLGL 770
Query: 264 EYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLE 323
+YLH +VYRD+KL+NL+LD +G +KI DFGLCKEG+ G TFCGTPE+LAPEVL
Sbjct: 771 QYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLT 830
Query: 324 DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAG 383
+ Y RAVDWWGLGV++YEM+ G PF D E +F+ I+ +E+R+PR LS EA S++
Sbjct: 831 ETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRR 890
Query: 384 LLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEF 443
LL+++P++RLG DA++V +H FF I+W ++ KK+ PPF P + D FDDEF
Sbjct: 891 LLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIPTIRGREDVSNFDDEF 950
Query: 444 TAQSITITPPDRYDSLGLLELDQRTHFPQFSYSA 477
T+++ +TPP +L +++ F F Y A
Sbjct: 951 TSEAPILTPP---REPRILSEEEQEMFRDFDYIA 981
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 326 bits (836), Expect = 3e-89
Identities = 153/332 (46%), Positives = 225/332 (67%), Gaps = 6/332 (1%)
Query: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 205
++ +++F+++++LGKG+FGKV+L R K TG YA+K+L+K+VI+ D+V T+TE R+L
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408
Query: 206 NTR-HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 264
R HPFLT L FQT DRL FVME+ NGG+L FH+ + R F E RARFY AEI+SAL
Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468
Query: 265 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 324
+LH + ++YRD+KL+N++LD +GH K+ DFG+CKEGI +G T TFCGTP+Y+APE+L++
Sbjct: 469 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528
Query: 325 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 384
YG AVDWW +GV++YEM+CG PF ++ + LFE IL +E+ +P L +A +L
Sbjct: 529 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSF 588
Query: 385 LKKDPKQRLGGGPSDAKE-VMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEF 443
+ K+P RLG + ++ H FF I+W + +++ PPF+P++ S D FD +F
Sbjct: 589 MTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDF 648
Query: 444 TAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
+ +TP D G L + + F FSY
Sbjct: 649 IKEEPVLTPIDE----GHLPMINQDEFRNFSY 676
>gi|133908623 protein kinase C, iota [Homo sapiens]
Length = 596
Score = 325 bits (834), Expect = 4e-89
Identities = 165/362 (45%), Positives = 235/362 (64%), Gaps = 19/362 (5%)
Query: 125 GSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILR 184
G ++ T E KA + + + DFD L+++G+G++ KV+LVR K T R YAMK+++
Sbjct: 231 GEEKEAMNTRES----GKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVK 286
Query: 185 KEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR 243
KE++ +++ TE V Q + HPFL L FQT RL FV+EY NGG+L FH+ R
Sbjct: 287 KELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQR 346
Query: 244 ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD 303
+R EE ARFY AEI AL YLH R ++YRD+KL+N++LD +GHIK+TD+G+CKEG+
Sbjct: 347 QRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRP 406
Query: 304 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD--- 354
G T TFCGTP Y+APE+L DYG +VDWW LGV+M+EMM GR PF N D
Sbjct: 407 GDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNT 466
Query: 355 HERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSIN 413
+ LF++IL ++IR PR+LS +A S+L L KDPK+RLG P ++ H FF +++
Sbjct: 467 EDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVD 526
Query: 414 WQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQF 473
W + QK+++PPFKP ++ E FD +FT + + +TP D D + + ++DQ + F F
Sbjct: 527 WDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD--DDI-VRKIDQ-SEFEGF 582
Query: 474 SY 475
Y
Sbjct: 583 EY 584
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 324 bits (830), Expect = 1e-88
Identities = 173/381 (45%), Positives = 240/381 (62%), Gaps = 9/381 (2%)
Query: 100 MRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVS-KARAKVTMNDFDYLKLL 158
+RA + + Q P ED + + S ST++ + + S AK T DFD+LK++
Sbjct: 113 VRAFLQMDSPKHQSDPSED--EDERSSQKLHSTSQNINLGPSGNPHAKPT--DFDFLKVI 168
Query: 159 GKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKY 217
GKG+FGKV+L + K G++YA+K+L+K++++ + E H + E VL +N +HPFL L Y
Sbjct: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
Query: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
+FQT ++L FV+++ NGGELFFHL RER F E RARFY AEI SAL YLHS +VYRD+K
Sbjct: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
Query: 278 LENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG 337
EN++LD GH+ +TDFGLCKEGI+ T TFCGTPEYLAPEV+ Y VDWW LG
Sbjct: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348
Query: 338 VVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGP 397
V+YEM+ G PFY +D +++ IL + + +S A S+L LL+KD + RL G
Sbjct: 349 AVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAK 407
Query: 398 SDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI--TITPPDR 455
D E+ H FF S++W D+VQKK+ PPF P V D R FD FT +++ ++
Sbjct: 408 EDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSD 467
Query: 456 YDSLGLLELDQRTHFPQFSYS 476
Y + L+ F FSY+
Sbjct: 468 YSIVNASVLEADDAFVGFSYA 488
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 324 bits (830), Expect = 1e-88
Identities = 173/381 (45%), Positives = 240/381 (62%), Gaps = 9/381 (2%)
Query: 100 MRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVS-KARAKVTMNDFDYLKLL 158
+RA + + Q P ED + + S ST++ + + S AK T DFD+LK++
Sbjct: 113 VRAFLQMDSPKHQSDPSED--EDERSSQKLHSTSQNINLGPSGNPHAKPT--DFDFLKVI 168
Query: 159 GKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNTRHPFLTALKY 217
GKG+FGKV+L + K G++YA+K+L+K++++ + E H + E VL +N +HPFL L Y
Sbjct: 169 GKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHY 228
Query: 218 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIK 277
+FQT ++L FV+++ NGGELFFHL RER F E RARFY AEI SAL YLHS +VYRD+K
Sbjct: 229 SFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLK 288
Query: 278 LENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLG 337
EN++LD GH+ +TDFGLCKEGI+ T TFCGTPEYLAPEV+ Y VDWW LG
Sbjct: 289 PENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLG 348
Query: 338 VVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGP 397
V+YEM+ G PFY +D +++ IL + + +S A S+L LL+KD + RL G
Sbjct: 349 AVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRL-GAK 407
Query: 398 SDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSI--TITPPDR 455
D E+ H FF S++W D+VQKK+ PPF P V D R FD FT +++ ++
Sbjct: 408 EDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSD 467
Query: 456 YDSLGLLELDQRTHFPQFSYS 476
Y + L+ F FSY+
Sbjct: 468 YSIVNASVLEADDAFVGFSYA 488
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 322 bits (824), Expect = 6e-88
Identities = 161/348 (46%), Positives = 232/348 (66%), Gaps = 8/348 (2%)
Query: 131 STTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIA 190
S E EV +A+ ++ +++F+++K+LGKG+FGKV+L K YA+K+L+K+VI+
Sbjct: 388 SPGENGEVRQGQAK-RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ 446
Query: 191 KDEVAHTVTESRVLQNTR-HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTE 249
D+V T+TE R+L R HP+LT L FQT DRL FVMEY NGG+L F + R R F E
Sbjct: 447 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 506
Query: 250 ERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKT 309
R+RFY AE+ SAL +LH V+YRD+KL+N++LD +GH K+ DFG+CKEGI +G T T
Sbjct: 507 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT 566
Query: 310 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRF 369
FCGTP+Y+APE+L++ +YG +VDWW LGV+MYEMM G+ PF + + LFE IL +++ +
Sbjct: 567 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY 626
Query: 370 PRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKE--VMEHRFFLSINWQDVVQKKLLPPFK 427
P LS EA S+L + K+P +RLG S E + +H FF I+W + QKK+ PPFK
Sbjct: 627 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK 686
Query: 428 PQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
P++ ++ D FD +FT + +T D +++ + F FSY
Sbjct: 687 PRIKTKRDVNNFDQDFTREEPVLTLVDE----AIVKQINQEEFKGFSY 730
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 320 bits (820), Expect = 2e-87
Identities = 157/331 (47%), Positives = 222/331 (67%), Gaps = 6/331 (1%)
Query: 146 KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQ 205
+V + DF++L +LGKG+FGKV+L K T YA+KIL+K+V+I D+V T+ E RVL
Sbjct: 333 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 392
Query: 206 NT-RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALE 264
+ PFLT L FQT DRL FVMEY NGG+L +H+ + F E +A FY AEI L
Sbjct: 393 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLF 452
Query: 265 YLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLED 324
+LH R ++YRD+KL+N+MLD +GHIKI DFG+CKE + DG T +TFCGTP+Y+APE++
Sbjct: 453 FLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAY 512
Query: 325 NDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGL 384
YG++VDWW GV++YEM+ G+ PF +D + LF+ I+ + +P++LS EA S+ GL
Sbjct: 513 QPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGL 572
Query: 385 LKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFT 444
+ K P +RLG GP ++V EH FF I+W+ + +++ PPFKP+V + FD FT
Sbjct: 573 MTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGK-GAENFDKFFT 631
Query: 445 AQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
+TPPD+ L + +DQ + F FSY
Sbjct: 632 RGQPVLTPPDQ---LVIANIDQ-SDFEGFSY 658
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 316 bits (809), Expect = 3e-86
Identities = 149/330 (45%), Positives = 218/330 (66%), Gaps = 2/330 (0%)
Query: 127 PSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKE 186
P + +T + + R ++ + DF++L +LGKG+FGKV+L K T YA+KIL+K+
Sbjct: 317 PEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD 376
Query: 187 VIIAKDEVAHTVTESRVLQNT-RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRER 245
V+I D+V T+ E RVL + PFLT L FQT DRL FVMEY NGG+L +H+ +
Sbjct: 377 VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVG 436
Query: 246 VFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGA 305
F E A FY AEI L +L S+ ++YRD+KL+N+MLD +GHIKI DFG+CKE I DG
Sbjct: 437 RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGV 496
Query: 306 TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILME 365
T KTFCGTP+Y+APE++ YG++VDWW GV++YEM+ G+ PF +D + LF+ I+
Sbjct: 497 TTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEH 556
Query: 366 EIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPP 425
+ +P+++S EA ++ GL+ K P +RLG GP +++ EH FF I+W+ + +K++ PP
Sbjct: 557 NVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPP 616
Query: 426 FKPQVTSEVDTRYFDDEFTAQSITITPPDR 455
+KP+ + FD FT +TPPD+
Sbjct: 617 YKPKACGR-NAENFDRFFTRHPPVLTPPDQ 645
>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
Length = 948
Score = 314 bits (804), Expect = 1e-85
Identities = 149/330 (45%), Positives = 222/330 (67%), Gaps = 4/330 (1%)
Query: 127 PSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKE 186
PS++ T + ++ +T+ DF +L +LG+G FGKV+L + +G +A+K L+K
Sbjct: 596 PSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKG 655
Query: 187 VIIAKDEVAHTVTESRVLQ---NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR 243
I+A+DEV + E R+L + HPFL L FQT + +CFVMEY+ GG+L H+
Sbjct: 656 DIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS 715
Query: 244 ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD 303
+ VF+E RA FY A +V L++LH +VYRD+KL+NL+LD +G++KI DFGLCKEG+
Sbjct: 716 D-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGY 774
Query: 304 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 363
G TFCGTPE+LAPEVL D Y RAVDWWGLGV++YEM+ G PF D E +F+ I+
Sbjct: 775 GDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV 834
Query: 364 MEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLL 423
+E+R+PR LS EA ++ LL+++P++RLG DA++V + FF ++ W+ ++ ++L
Sbjct: 835 NDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLP 894
Query: 424 PPFKPQVTSEVDTRYFDDEFTAQSITITPP 453
PPF P ++ D FD+EFT ++ T++PP
Sbjct: 895 PPFVPTLSGRTDVSNFDEEFTGEAPTLSPP 924
>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
Length = 942
Score = 314 bits (804), Expect = 1e-85
Identities = 149/330 (45%), Positives = 222/330 (67%), Gaps = 4/330 (1%)
Query: 127 PSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKE 186
PS++ T + ++ +T+ DF +L +LG+G FGKV+L + +G +A+K L+K
Sbjct: 590 PSETQETPGPALCSPLRKSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKG 649
Query: 187 VIIAKDEVAHTVTESRVLQ---NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSR 243
I+A+DEV + E R+L + HPFL L FQT + +CFVMEY+ GG+L H+
Sbjct: 650 DIVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHS 709
Query: 244 ERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISD 303
+ VF+E RA FY A +V L++LH +VYRD+KL+NL+LD +G++KI DFGLCKEG+
Sbjct: 710 D-VFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGY 768
Query: 304 GATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELIL 363
G TFCGTPE+LAPEVL D Y RAVDWWGLGV++YEM+ G PF D E +F+ I+
Sbjct: 769 GDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIV 828
Query: 364 MEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLL 423
+E+R+PR LS EA ++ LL+++P++RLG DA++V + FF ++ W+ ++ ++L
Sbjct: 829 NDEVRYPRFLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLP 888
Query: 424 PPFKPQVTSEVDTRYFDDEFTAQSITITPP 453
PPF P ++ D FD+EFT ++ T++PP
Sbjct: 889 PPFVPTLSGRTDVSNFDEEFTGEAPTLSPP 918
>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 312 bits (800), Expect = 4e-85
Identities = 154/336 (45%), Positives = 222/336 (66%), Gaps = 13/336 (3%)
Query: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNT 207
+ DFD ++++G+G++ KV+LVR K + YAMK+++KE++ +++ TE V Q +
Sbjct: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
Query: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLH 267
+PFL L FQT RL V+EY NGG+L FH+ R+R EE ARFY AEI AL +LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
Query: 268 SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY 327
R ++YRD+KL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
Query: 328 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HERLFELILMEEIRFPRTLSPEAKSL 380
G +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR LS +A +
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
Query: 381 LAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYF 439
L G L KDPK+RLG P ++ H FF SI+W + +K+ LPPF+PQ+T + F
Sbjct: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
Query: 440 DDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
D +FT++ + +TP D D++ ++ ++ F F Y
Sbjct: 366 DTQFTSEPVQLTPDDE-DAIKRID---QSEFEGFEY 397
>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
Length = 409
Score = 312 bits (800), Expect = 4e-85
Identities = 154/336 (45%), Positives = 222/336 (66%), Gaps = 13/336 (3%)
Query: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNT 207
+ DFD ++++G+G++ KV+LVR K + YAMK+++KE++ +++ TE V Q +
Sbjct: 66 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 125
Query: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLH 267
+PFL L FQT RL V+EY NGG+L FH+ R+R EE ARFY AEI AL +LH
Sbjct: 126 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 185
Query: 268 SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY 327
R ++YRD+KL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +Y
Sbjct: 186 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 245
Query: 328 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HERLFELILMEEIRFPRTLSPEAKSL 380
G +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR LS +A +
Sbjct: 246 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 305
Query: 381 LAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYF 439
L G L KDPK+RLG P ++ H FF SI+W + +K+ LPPF+PQ+T + F
Sbjct: 306 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 365
Query: 440 DDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
D +FT++ + +TP D D++ ++ ++ F F Y
Sbjct: 366 DTQFTSEPVQLTPDDE-DAIKRID---QSEFEGFEY 397
>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
Length = 592
Score = 312 bits (800), Expect = 4e-85
Identities = 154/336 (45%), Positives = 222/336 (66%), Gaps = 13/336 (3%)
Query: 149 MNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL-QNT 207
+ DFD ++++G+G++ KV+LVR K + YAMK+++KE++ +++ TE V Q +
Sbjct: 249 LQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQAS 308
Query: 208 RHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLH 267
+PFL L FQT RL V+EY NGG+L FH+ R+R EE ARFY AEI AL +LH
Sbjct: 309 SNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLH 368
Query: 268 SRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDY 327
R ++YRD+KL+N++LD DGHIK+TD+G+CKEG+ G T TFCGTP Y+APE+L +Y
Sbjct: 369 ERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEY 428
Query: 328 GRAVDWWGLGVVMYEMMCGRLPF----YNQD---HERLFELILMEEIRFPRTLSPEAKSL 380
G +VDWW LGV+M+EMM GR PF N D + LF++IL + IR PR LS +A +
Sbjct: 429 GFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHV 488
Query: 381 LAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYF 439
L G L KDPK+RLG P ++ H FF SI+W + +K+ LPPF+PQ+T + F
Sbjct: 489 LKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNF 548
Query: 440 DDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
D +FT++ + +TP D D++ ++ ++ F F Y
Sbjct: 549 DTQFTSEPVQLTPDDE-DAIKRID---QSEFEGFEY 580
>gi|4506737 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Homo
sapiens]
Length = 525
Score = 306 bits (783), Expect = 4e-83
Identities = 152/326 (46%), Positives = 214/326 (65%), Gaps = 6/326 (1%)
Query: 134 EEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKA---TGRYYAMKILRKEVII- 189
E E +V++ K+ F+ L++LGKG +GKV VR+ TG+ +AMK+L+K +I+
Sbjct: 73 EISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVR 132
Query: 190 -AKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFT 248
AKD AHT E +L+ +HPF+ L YAFQT +L ++EY +GGELF L RE +F
Sbjct: 133 NAKD-TAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFM 191
Query: 249 EERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMK 308
E+ A FY AEI AL +LH + ++YRD+K EN+ML+ GH+K+TDFGLCKE I DG
Sbjct: 192 EDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTH 251
Query: 309 TFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIR 368
TFCGT EY+APE+L + + RAVDWW LG +MY+M+ G PF ++ ++ + IL ++
Sbjct: 252 TFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLN 311
Query: 369 FPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 428
P L+ EA+ LL LLK++ RLG GP DA EV H FF INW++++ +K+ PPFKP
Sbjct: 312 LPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 371
Query: 429 QVTSEVDTRYFDDEFTAQSITITPPD 454
+ SE D FD +FT Q+ +P D
Sbjct: 372 LLQSEEDVSQFDSKFTRQTPVDSPDD 397
>gi|55953117 ribosomal protein S6 kinase, 70kDa, polypeptide 2 [Homo
sapiens]
Length = 482
Score = 304 bits (778), Expect = 1e-82
Identities = 162/370 (43%), Positives = 229/370 (61%), Gaps = 18/370 (4%)
Query: 113 RAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREK 172
RA G +P+ + E E +V+ ++ + F+ L++LGKG +GKV VR+
Sbjct: 35 RAAGLEPVGHY-------EEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKV 87
Query: 173 A---TGRYYAMKILRKEVII--AKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCF 227
G+ YAMK+LRK I+ AKD AHT E +L++ +HPF+ L YAFQT +L
Sbjct: 88 QGTNLGKIYAMKVLRKAKIVRNAKD-TAHTRAERNILESVKHPFIVELAYAFQTGGKLYL 146
Query: 228 VMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDG 287
++E +GGELF HL RE +F E+ A FY AEI AL +LHS+ ++YRD+K EN+ML G
Sbjct: 147 ILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQG 206
Query: 288 HIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR 347
HIK+TDFGLCKE I +GA TFCGT EY+APE+L + + RAVDWW LG +MY+M+ G
Sbjct: 207 HIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGS 266
Query: 348 LPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHR 407
PF ++ ++ + I+ ++ P L+P+A+ L+ LK++P QR+GGGP DA +V H
Sbjct: 267 PPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHP 326
Query: 408 FFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQR 467
FF +NW D++ ++ PPF+P + SE D FD FT Q TP D D L E +
Sbjct: 327 FFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQ----TPVDSPDDTALSESANQ 382
Query: 468 THFPQFSYSA 477
F F+Y A
Sbjct: 383 A-FLGFTYVA 391
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 302 bits (773), Expect = 5e-82
Identities = 154/356 (43%), Positives = 222/356 (62%), Gaps = 12/356 (3%)
Query: 127 PSDS-STTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRK 185
PS S S T+ + ++ ++DF +L +LGKG+FGKV+L + + YA+KIL+K
Sbjct: 325 PSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKK 384
Query: 186 EVIIAKDEVAHTVTESRVLQ------NTRHPFLTALKYAFQTHDRLCFVMEYANGGELFF 239
+VI+ D+V T+ E RVL R FLT L FQT DRL FVMEY GG+L +
Sbjct: 385 DVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMY 444
Query: 240 HLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKE 299
H+ + F E A FY AEI L +LH++ ++YRD+KL+N+MLD +GHIKITDFG+CKE
Sbjct: 445 HIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKE 504
Query: 300 GISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLF 359
+ G T +TFCGTP+Y+APE++ YG++VDWW GV++YEM+ G+ PF +D E LF
Sbjct: 505 NVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELF 564
Query: 360 ELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQ 419
+ I+ + + +P++LS EA ++ G L K P +RLG GP + H FF I+W+ + +
Sbjct: 565 QAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLER 624
Query: 420 KKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
++ PPF+P+ FD FT + +TPPDR L L +DQ F F+Y
Sbjct: 625 LEIPPPFRPRPCGR-SGENFDKFFTRAAPALTPPDR---LVLASIDQ-ADFQGFTY 675
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 300 bits (768), Expect = 2e-81
Identities = 153/359 (42%), Positives = 218/359 (60%), Gaps = 14/359 (3%)
Query: 118 DPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRY 177
D +D C P E + + K+ + DF K+LGKG+FGKV L K T ++
Sbjct: 351 DEVDKMCHLPEPELNKERPSLQI-----KLKIEDFILHKMLGKGSFGKVFLAEFKKTNQF 405
Query: 178 YAMKILRKEVIIAKDEVAHTVTESRVLQNT-RHPFLTALKYAFQTHDRLCFVMEYANGGE 236
+A+K L+K+V++ D+V T+ E RVL HPFLT + FQT + L FVMEY NGG+
Sbjct: 406 FAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGD 465
Query: 237 LFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGL 296
L +H+ F RA FY AEI+ L++LHS+ +VYRD+KL+N++LDKDGHIKI DFG+
Sbjct: 466 LMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGM 525
Query: 297 CKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE 356
CKE + A TFCGTP+Y+APE+L Y +VDWW GV++YEM+ G+ PF+ QD E
Sbjct: 526 CKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEE 585
Query: 357 RLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQD 416
LF I M+ +PR L EAK LL L ++P++RLG ++ +H F INW++
Sbjct: 586 ELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPEKRLG----VRGDIRQHPLFREINWEE 641
Query: 417 VVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475
+ +K++ PPF+P+V S D FD EF + ++ DR L+ + F FS+
Sbjct: 642 LERKEIDPPFRPKVKSPFDCSNFDKEFLNEKPRLSFADR----ALINSMDQNMFRNFSF 696
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,970,121
Number of Sequences: 37866
Number of extensions: 851080
Number of successful extensions: 4171
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 740
Number of HSP's successfully gapped in prelim test: 114
Number of HSP's that attempted gapping in prelim test: 1850
Number of HSP's gapped (non-prelim): 1000
length of query: 481
length of database: 18,247,518
effective HSP length: 106
effective length of query: 375
effective length of database: 14,233,722
effective search space: 5337645750
effective search space used: 5337645750
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.