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Search of human proteins with 4501897
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4501897 activin A receptor, type IIA precursor [Homo
sapiens]
(513 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 1071 0.0
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 754 0.0
gi|15451916 bone morphogenetic protein receptor type II precurso... 286 3e-77
gi|67782324 transforming growth factor, beta receptor II isoform... 285 7e-77
gi|67782326 transforming growth factor, beta receptor II isoform... 285 7e-77
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 246 3e-65
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 240 2e-63
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 238 1e-62
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 235 6e-62
gi|4759226 transforming growth factor, beta receptor I isoform 1... 232 5e-61
gi|195963412 transforming growth factor, beta receptor I isoform... 232 7e-61
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 229 3e-60
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 224 2e-58
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 217 2e-56
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 217 2e-56
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 214 2e-55
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 214 2e-55
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 207 2e-53
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 203 3e-52
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 176 5e-44
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 174 1e-43
gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo... 108 1e-23
gi|223671888 interleukin-1 receptor-associated kinase 4 isoform ... 97 3e-20
gi|223671885 interleukin-1 receptor-associated kinase 4 isoform ... 97 3e-20
gi|223671883 interleukin-1 receptor-associated kinase 4 isoform ... 97 3e-20
gi|166795293 interleukin-1 receptor-associated kinase 4 isoform ... 97 3e-20
gi|166795295 interleukin-1 receptor-associated kinase 4 isoform ... 97 3e-20
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 87 3e-17
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 87 3e-17
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 87 3e-17
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 1071 bits (2770), Expect = 0.0
Identities = 513/513 (100%), Positives = 513/513 (100%)
Query: 1 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC 60
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
Sbjct: 1 MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC 60
Query: 61 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM 120
FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
Sbjct: 61 FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM 120
Query: 121 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP 180
EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
Sbjct: 121 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP 180
Query: 181 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG 240
PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
Sbjct: 181 PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG 240
Query: 241 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL 300
MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
Sbjct: 241 MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL 300
Query: 301 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV 360
AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
Sbjct: 301 AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV 360
Query: 361 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG 420
GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
Sbjct: 361 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG 420
Query: 421 QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT 480
QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
Sbjct: 421 QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT 480
Query: 481 QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL 513
QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
Sbjct: 481 QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL 513
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 754 bits (1947), Expect = 0.0
Identities = 343/508 (67%), Positives = 431/508 (84%), Gaps = 2/508 (0%)
Query: 7 LAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKN 66
+A A+ S +G+ G +ET+EC+++NANWE +RTNQ+G+E C G++DKR HC+A+W+N
Sbjct: 6 VALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRN 65
Query: 67 ISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPT 126
SG+IE+VK+GCWLDD NCYDR +CV +++P+VYFCCCEGN CNE+F++ PE + T
Sbjct: 66 SSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVT 125
Query: 127 SNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPL 186
P P +L YSL+P+ ++ IV+ AFW+YRH K Y V + +DPGPPPPSPL
Sbjct: 126 YEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIH-EDPGPPPPSPL 184
Query: 187 LGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENI 246
+GLKPLQLLE+KARGRFGCVWKAQL+N++VAVKIFP+QDKQSWQ+E E++S PGMKHEN+
Sbjct: 185 VGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENL 244
Query: 247 LQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHED 306
LQFI AEKRG++++V+LWLITAFH+KGSL+D+LK N+++WNELCH+AETM+RGL+YLHED
Sbjct: 245 LQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHED 304
Query: 307 IPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRY 365
+P + +GHKP+I+HRD KSKNVLLK++LTA +ADFGLA++FE GK GDTHGQVGTRRY
Sbjct: 305 VPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRY 364
Query: 366 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSL 425
MAPEVLEGAINFQRDAFLRIDMYAMGLVLWEL SRC AADGPVDEYMLPFEEEIGQHPSL
Sbjct: 365 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 424
Query: 426 EDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRL 485
E++QEVVVHKK RP ++D+W KH G+A LC TIEECWDHDAEARLSAGCV ER++ ++R
Sbjct: 425 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRS 484
Query: 486 TNIITTEDIVTVVTMVTNVDFPPKESSL 513
N T++ +V++VT VTNVD PPKESS+
Sbjct: 485 VNGTTSDCLVSLVTSVTNVDLPPKESSI 512
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 286 bits (732), Expect = 3e-77
Identities = 166/450 (36%), Positives = 255/450 (56%), Gaps = 32/450 (7%)
Query: 60 CFATWKNISGSIEIVKQGCWL---DDINCYDRTDCVEKKDSPEVY-----FCCCEGNMCN 111
C+ W+ G I +VKQGCW D C+ +CV P + FCCC ++CN
Sbjct: 66 CYGLWEKSKGDINLVKQGCWSHIGDPQECHYE-ECVVTTTPPSIQNGTYRFCCCSTDLCN 124
Query: 112 EKFSY-FPEMEVTQPTSNPVTPKPPYYN---ILLYSLVPLMLIAGIVICAFWVYRHHKMA 167
F+ FP P + P++P P +N ++ +L + ++A +++ + YR
Sbjct: 125 VNFTENFPP-----PDTTPLSP-PHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGD 178
Query: 168 YPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQ 227
L P L L L+LLE+ RGR+G V+K L VAVK+F ++Q
Sbjct: 179 RKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQ 238
Query: 228 SWQNEYEVYSLPGMKHENILQFIGAEKRGTSVD-VDLWLITAFHEKGSLSDFLKANVVSW 286
++ NE +Y +P M+H+NI +FI ++R T+ ++ L+ ++ GSL +L + W
Sbjct: 239 NFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDW 298
Query: 287 NELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALK 346
C +A ++ RGLAYLH ++P D +KPAISHRD+ S+NVL+KN+ T I+DFGL+++
Sbjct: 299 VSSCRLAHSVTRGLAYLHTELP-RGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMR 357
Query: 347 F------EAGKSAGDTHGQVGTRRYMAPEVLEGAINFQ--RDAFLRIDMYAMGLVLWELA 398
G+ +VGT RYMAPEVLEGA+N + A ++DMYA+GL+ WE+
Sbjct: 358 LTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIF 417
Query: 399 SRCT--AADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAMLC 455
RCT V EY + F+ E+G HP+ EDMQ +V +K+RP + W++++ + L
Sbjct: 418 MRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLK 477
Query: 456 ETIEECWDHDAEARLSAGCVGERITQMQRL 485
ETIE+CWD DAEARL+A C ER+ ++ +
Sbjct: 478 ETIEDCWDQDAEARLTAQCAEERMAELMMI 507
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 285 bits (729), Expect = 7e-77
Identities = 164/430 (38%), Positives = 241/430 (56%), Gaps = 41/430 (9%)
Query: 93 EKKDSPEVYFCC-CEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIA 151
EKK E +F C C + CN+ + E + P V + + SL+P + +A
Sbjct: 125 EKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVI-----FQVTGISLLPPLGVA 179
Query: 152 GIVICAFWVYRHHKMAYPPVLVPT-----------------QDPGPPPPSPLLG------ 188
VI F+ YR ++ T +D S
Sbjct: 180 ISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNT 239
Query: 189 -LKPLQLLEVKARGRFGCVWKAQLLN------EYVAVKIFPIQDKQSWQNEYEVYSLPGM 241
L P++L + +GRF V+KA+L E VAVKIFP ++ SW+ E +++S +
Sbjct: 240 ELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINL 299
Query: 242 KHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLA 301
KHENILQF+ AE+R T + WLITAFH KG+L ++L +V+SW +L + ++ARG+A
Sbjct: 300 KHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIA 359
Query: 302 YLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQ 359
+LH D P I HRD+KS N+L+KN+LT C+ DFGL+L+ + S D GQ
Sbjct: 360 HLHSDHTPCGRPKMP-IVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 418
Query: 360 VGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEE 418
VGT RYMAPEVLE +N + ++F + D+Y+M LVLWE+ SRC A G V +Y PF +
Sbjct: 419 VGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAV-GEVKDYEPPFGSK 477
Query: 419 IGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER 478
+ +HP +E M++ V+ + RP + +W H G+ M+CET+ ECWDHD EARL+A CV ER
Sbjct: 478 VREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER 537
Query: 479 ITQMQRLTNI 488
++++ L +
Sbjct: 538 FSELEHLDRL 547
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 285 bits (729), Expect = 7e-77
Identities = 164/430 (38%), Positives = 241/430 (56%), Gaps = 41/430 (9%)
Query: 93 EKKDSPEVYFCC-CEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIA 151
EKK E +F C C + CN+ + E + P V + + SL+P + +A
Sbjct: 150 EKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVI-----FQVTGISLLPPLGVA 204
Query: 152 GIVICAFWVYRHHKMAYPPVLVPT-----------------QDPGPPPPSPLLG------ 188
VI F+ YR ++ T +D S
Sbjct: 205 ISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNT 264
Query: 189 -LKPLQLLEVKARGRFGCVWKAQLLN------EYVAVKIFPIQDKQSWQNEYEVYSLPGM 241
L P++L + +GRF V+KA+L E VAVKIFP ++ SW+ E +++S +
Sbjct: 265 ELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINL 324
Query: 242 KHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLA 301
KHENILQF+ AE+R T + WLITAFH KG+L ++L +V+SW +L + ++ARG+A
Sbjct: 325 KHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIA 384
Query: 302 YLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQ 359
+LH D P I HRD+KS N+L+KN+LT C+ DFGL+L+ + S D GQ
Sbjct: 385 HLHSDHTPCGRPKMP-IVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 443
Query: 360 VGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEE 418
VGT RYMAPEVLE +N + ++F + D+Y+M LVLWE+ SRC A G V +Y PF +
Sbjct: 444 VGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAV-GEVKDYEPPFGSK 502
Query: 419 IGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER 478
+ +HP +E M++ V+ + RP + +W H G+ M+CET+ ECWDHD EARL+A CV ER
Sbjct: 503 VREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER 562
Query: 479 ITQMQRLTNI 488
++++ L +
Sbjct: 563 FSELEHLDRL 572
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 246 bits (629), Expect = 3e-65
Identities = 161/463 (34%), Positives = 244/463 (52%), Gaps = 58/463 (12%)
Query: 59 HCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFC----CCEGNMCNEKF 114
HCFA + + GC Y+ +D + KDSP+ CC N+CN+
Sbjct: 81 HCFAIIEEDDQGETTLASGCMK-----YEGSD-FQCKDSPKAQLRRTIECCRTNLCNQYL 134
Query: 115 SYFPEMEVTQPTSNPVTPKPPY-----YNILLYSLVPLMLIAGIVICAFWVYRHH----- 164
QPT PV P + + +LL S+ + +IA I+ + + Y+H+
Sbjct: 135 ---------QPTLPPVVIGPFFDGSIRWLVLLISMA-VCIIAMIIFSSCFCYKHYCKSIS 184
Query: 165 -----------KMAYPPV-------LVPTQDPGPPPPSPLLG----LKPLQLLEVKARGR 202
A+ PV + +Q G PLL K +Q++ +GR
Sbjct: 185 SRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGR 244
Query: 203 FGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVD 262
+G VW + E VAVK+F ++ SW E E+Y M+HENIL FI A+ +GT
Sbjct: 245 YGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQ 304
Query: 263 LWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRD 322
L+LIT +HE GSL DFLK + L +A + A GL +LH +I G + KPAI+HRD
Sbjct: 305 LYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQG--KPAIAHRD 362
Query: 323 IKSKNVLLKNNLTACIADFGLALKFEAGKSAGDT--HGQVGTRRYMAPEVLEGAINFQR- 379
+KSKN+L+K N + CIAD GLA+KF + + D + +VGT+RYMAPEVL+ ++N
Sbjct: 363 LKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHF 422
Query: 380 DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRP 439
++ D+Y+ GL++WE+A RC G V+EY LP+ + PS EDM+EVV K+ RP
Sbjct: 423 QPYIMADIYSFGLIIWEMARRCITG-GIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRP 481
Query: 440 VLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQM 482
++ + W + + + + ECW H+ +RL+A + + + +M
Sbjct: 482 IVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 240 bits (613), Expect = 2e-63
Identities = 159/465 (34%), Positives = 240/465 (51%), Gaps = 51/465 (10%)
Query: 59 HCFATWKNISGSIEIVKQGCWL---DDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFS 115
+CF + + +V GC D C D T ++ S E CC E N CN+
Sbjct: 52 YCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRD-TPIPHQRRSIE---CCTERNECNKDL- 106
Query: 116 YFPEMEVTQPTSNPVTPK-----PPYYNILLYSLV--PLMLIAGIVICAFWVYRHH---- 164
PT P+ + P ++ LL S+ L+L+ I+ C F R
Sbjct: 107 --------HPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPR 158
Query: 165 --------KMAYPP------VLVPTQDPGPPPPSPLLG----LKPLQLLEVKARGRFGCV 206
+ PP ++ +Q G PLL K +Q+++ +GR+G V
Sbjct: 159 YSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEV 218
Query: 207 WKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLI 266
W + E VAVK+F ++ SW E E+Y M+HENIL FI A+ +GT L+LI
Sbjct: 219 WMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLI 278
Query: 267 TAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSK 326
T +HE GSL D+LK+ + + +A + GL +LH +I KPAI+HRD+KSK
Sbjct: 279 TDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEI--FSTQGKPAIAHRDLKSK 336
Query: 327 NVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAINFQR-DAFL 383
N+L+K N T CIAD GLA+KF + + D + +VGT+RYM PEVL+ ++N +++
Sbjct: 337 NILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYI 396
Query: 384 RIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRD 443
DMY+ GL+LWE+A RC + G V+EY LP+ + + PS EDM+E+V KK RP +
Sbjct: 397 MADMYSFGLILWEVARRCVSG-GIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPN 455
Query: 444 YWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 488
W + + + + ECW H+ +RL+A V + + +M +I
Sbjct: 456 RWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDI 500
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 238 bits (607), Expect = 1e-62
Identities = 150/458 (32%), Positives = 245/458 (53%), Gaps = 53/458 (11%)
Query: 60 CFATWKNISGSIEIVKQGCWLDDIN----CYDRTDCVEKKDSPEVYFCCCEGNMCNEKFS 115
C+A+ +G +++K L ++N C+ + + + CC + CN
Sbjct: 46 CWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTE--------CCFTDFCNN--- 94
Query: 116 YFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAY-----PP 170
+ + PT++P PK + + VP+ L++ + W + + +Y P
Sbjct: 95 ----ITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPN 150
Query: 171 VLVPTQD-------------------PGPPPPSPLLGLKPLQ----LLEVKARGRFGCVW 207
V P + G PLL + + L E+ +GRFG VW
Sbjct: 151 VEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVW 210
Query: 208 KAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLIT 267
+ E VAVKIF +D++SW E E+Y ++HENIL FI A+ + LWL++
Sbjct: 211 HGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVS 270
Query: 268 AFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKN 327
+HE+GSL D+L N+V+ + +A ++A GLA+LH +I G + KPAI+HRDIKSKN
Sbjct: 271 EYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQG--KPAIAHRDIKSKN 328
Query: 328 VLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAINFQ-RDAFLR 384
+L+K T IAD GLA+K ++ + D + +VGT+RYMAPE+L+ +N ++F R
Sbjct: 329 ILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKR 388
Query: 385 IDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDY 444
D+Y++GLV WE+A RC+ G V+EY LP+ + + PS+E+M++VV +K RP + +
Sbjct: 389 ADIYSVGLVYWEIARRCSVG-GIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQ 447
Query: 445 WQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQM 482
WQ + ++ + ECW + ARL+A + + I+Q+
Sbjct: 448 WQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 485
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 235 bits (600), Expect = 6e-62
Identities = 143/410 (34%), Positives = 226/410 (55%), Gaps = 41/410 (10%)
Query: 104 CCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRH 163
CC + CN + + PT++P PK + + VP+ L++ + W +
Sbjct: 36 CCFTDFCNN-------ITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQG 88
Query: 164 HKMAY-----PPVLVPTQD-------------------PGPPPPSPLLGLKPLQ----LL 195
+ +Y P V P + G PLL + + L
Sbjct: 89 RQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQ 148
Query: 196 EVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKR 255
E+ +GRFG VW + E VAVKIF +D++SW E E+Y ++HENIL FI A+ +
Sbjct: 149 EIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNK 208
Query: 256 GTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHK 315
LWL++ +HE+GSL D+L N+V+ + +A ++A GLA+LH +I G + K
Sbjct: 209 DNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQG--K 266
Query: 316 PAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEG 373
PAI+HRDIKSKN+L+K T IAD GLA+K ++ + D + +VGT+RYMAPE+L+
Sbjct: 267 PAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDD 326
Query: 374 AINFQ-RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVV 432
+N ++F R D+Y++GLV WE+A RC+ G V+EY LP+ + + PS+E+M++VV
Sbjct: 327 TMNVNIFESFKRADIYSVGLVYWEIARRCSVG-GIVEEYQLPYYDMVPSDPSIEEMRKVV 385
Query: 433 VHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQM 482
+K RP + + WQ + ++ + ECW + ARL+A + + I+Q+
Sbjct: 386 CDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 435
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 232 bits (592), Expect = 5e-61
Identities = 141/409 (34%), Positives = 222/409 (54%), Gaps = 31/409 (7%)
Query: 104 CCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRH 163
CC + CN+ P + P PV + + + LML+ + IC H
Sbjct: 100 CCNQDHCNK--IELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLM--VYICHNRTVIH 155
Query: 164 HKM-----------------AYPPVLVPTQDPGPPPPSPLLGLKPLQ----LLEVKARGR 202
H++ ++ G PLL + + L E +GR
Sbjct: 156 HRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGR 215
Query: 203 FGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVD 262
FG VW+ + E VAVKIF ++++SW E E+Y ++HENIL FI A+ +
Sbjct: 216 FGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQ 275
Query: 263 LWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRD 322
LWL++ +HE GSL D+L V+ + +A + A GLA+LH +I G + KPAI+HRD
Sbjct: 276 LWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQG--KPAIAHRD 333
Query: 323 IKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAINFQR- 379
+KSKN+L+K N T CIAD GLA++ ++ D + +VGT+RYMAPEVL+ +IN +
Sbjct: 334 LKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHF 393
Query: 380 DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRP 439
++F R D+YAMGLV WE+A RC+ G ++Y LP+ + + PS+E+M++VV +K RP
Sbjct: 394 ESFKRADIYAMGLVFWEIARRCSIG-GIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRP 452
Query: 440 VLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNI 488
+ + WQ + ++ + + ECW + ARL+A + + ++Q+ + I
Sbjct: 453 NIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGI 501
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 232 bits (591), Expect = 7e-61
Identities = 122/302 (40%), Positives = 191/302 (63%), Gaps = 6/302 (1%)
Query: 190 KPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQF 249
+ + L E +GRFG VW+ + E VAVKIF ++++SW E E+Y ++HENIL F
Sbjct: 126 RTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGF 185
Query: 250 IGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPG 309
I A+ + LWL++ +HE GSL D+L V+ + +A + A GLA+LH +I G
Sbjct: 186 IAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVG 245
Query: 310 LKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMA 367
+ KPAI+HRD+KSKN+L+K N T CIAD GLA++ ++ D + +VGT+RYMA
Sbjct: 246 TQG--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMA 303
Query: 368 PEVLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLE 426
PEVL+ +IN + ++F R D+YAMGLV WE+A RC+ G ++Y LP+ + + PS+E
Sbjct: 304 PEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIG-GIHEDYQLPYYDLVPSDPSVE 362
Query: 427 DMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLT 486
+M++VV +K RP + + WQ + ++ + + ECW + ARL+A + + ++Q+ +
Sbjct: 363 EMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQE 422
Query: 487 NI 488
I
Sbjct: 423 GI 424
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 229 bits (585), Expect = 3e-60
Identities = 122/296 (41%), Positives = 190/296 (64%), Gaps = 6/296 (2%)
Query: 190 KPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQF 249
+ + L E+ +GRFG VW + E VAVKIF +D++SW E E+Y ++HENIL F
Sbjct: 113 RTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGF 172
Query: 250 IGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPG 309
I A+ + LWL++ +HE+GSL D+L N+V+ + +A ++A GLA+LH +I G
Sbjct: 173 IAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVG 232
Query: 310 LKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMA 367
+ KPAI+HRDIKSKN+L+K T IAD GLA+K ++ + D + +VGT+RYMA
Sbjct: 233 TQG--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMA 290
Query: 368 PEVLEGAINFQ-RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLE 426
PE+L+ +N ++F R D+Y++GLV WE+A RC+ G V+EY LP+ + + PS+E
Sbjct: 291 PEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVG-GIVEEYQLPYYDMVPSDPSIE 349
Query: 427 DMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQM 482
+M++VV +K RP + + WQ + ++ + ECW + ARL+A + + I+Q+
Sbjct: 350 EMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 405
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 224 bits (570), Expect = 2e-58
Identities = 141/426 (33%), Positives = 230/426 (53%), Gaps = 46/426 (10%)
Query: 91 CVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPP--YYNILLYSLV--P 146
C+ +D + CC + CN +++ P+ + P+ P + + L ++ P
Sbjct: 84 CLSSEDLRNTH--CCYTDYCNR-------IDLRVPSGHLKEPEHPSMWGPVELVGIIAGP 134
Query: 147 LMLIAGIVICAFWVYRHHKMAYPP-VLVPTQDP----------------------GPPPP 183
+ L+ I+I F V +H+ Y + +DP G
Sbjct: 135 VFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSG 194
Query: 184 SPLLG----LKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLP 239
PL + + L E+ +GRFG VW+ + VAVKIF ++++SW E E+Y
Sbjct: 195 LPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTV 254
Query: 240 GMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARG 299
++HENIL FI A+ + LWL++ +HE GSL D+L V+ + +A + A G
Sbjct: 255 MLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASG 314
Query: 300 LAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--TH 357
LA+LH +I G + KP I+HRD+KSKN+L+K N IAD GLA++ +A D +
Sbjct: 315 LAHLHMEIVGTQG--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPN 372
Query: 358 GQVGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFE 416
+VGT+RYMAPEVL+ IN + D+F D+YA+GLV WE+A RC + G +EY LP+
Sbjct: 373 QRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG-GVHEEYQLPYY 431
Query: 417 EEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVG 476
+ + PS+E+M++VV +K RP + ++WQ + + ++ + + ECW + ARL+A +
Sbjct: 432 DLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIK 491
Query: 477 ERITQM 482
+ ++Q+
Sbjct: 492 KTLSQL 497
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 217 bits (553), Expect = 2e-56
Identities = 120/306 (39%), Positives = 185/306 (60%), Gaps = 6/306 (1%)
Query: 190 KPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQF 249
+ + LLE +GR+G VW+ E VAVKIF +D++SW E E+Y+ ++HENIL F
Sbjct: 206 RQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGF 265
Query: 250 IGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPG 309
I ++ LWLIT +HE GSL D+L+ + I ++A GLA+LH +I G
Sbjct: 266 IASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFG 325
Query: 310 LKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMA 367
+ KPAI+HRD+KSKN+L+K N CIAD GLA+ + D + +VGT+RYMA
Sbjct: 326 TQG--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMA 383
Query: 368 PEVLEGAINFQ-RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLE 426
PEVL+ I D++ R+D++A GLVLWE+A R ++G V++Y PF + + PS E
Sbjct: 384 PEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARR-MVSNGIVEDYKPPFYDVVPNDPSFE 442
Query: 427 DMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLT 486
DM++VV ++RP + + W + L + ++ECW + ARL+A + + +T++
Sbjct: 443 DMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSL 502
Query: 487 NIITTE 492
+ + T+
Sbjct: 503 DKLKTD 508
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 217 bits (553), Expect = 2e-56
Identities = 120/306 (39%), Positives = 185/306 (60%), Gaps = 6/306 (1%)
Query: 190 KPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQF 249
+ + LLE +GR+G VW+ E VAVKIF +D++SW E E+Y+ ++HENIL F
Sbjct: 206 RQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGF 265
Query: 250 IGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPG 309
I ++ LWLIT +HE GSL D+L+ + I ++A GLA+LH +I G
Sbjct: 266 IASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFG 325
Query: 310 LKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMA 367
+ KPAI+HRD+KSKN+L+K N CIAD GLA+ + D + +VGT+RYMA
Sbjct: 326 TQG--KPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMA 383
Query: 368 PEVLEGAINFQ-RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLE 426
PEVL+ I D++ R+D++A GLVLWE+A R ++G V++Y PF + + PS E
Sbjct: 384 PEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARR-MVSNGIVEDYKPPFYDVVPNDPSFE 442
Query: 427 DMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLT 486
DM++VV ++RP + + W + L + ++ECW + ARL+A + + +T++
Sbjct: 443 DMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSL 502
Query: 487 NIITTE 492
+ + T+
Sbjct: 503 DKLKTD 508
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 214 bits (544), Expect = 2e-55
Identities = 139/401 (34%), Positives = 214/401 (53%), Gaps = 39/401 (9%)
Query: 104 CCEGNMCNEKFSYFPEMEVTQPTSN-PVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYR 162
CC+ ++CN S +E TQP S P T ++L ++ L+ + + + W R
Sbjct: 89 CCDSHLCNHNVSLV--LEATQPPSEQPGTDGQ--LALILGPVLALLALVALGVLGLWHVR 144
Query: 163 ---------HHKMAYPPVLVPTQDPGPPPPSPLL----------GL---------KPLQL 194
H ++ +++ + G LL GL + + L
Sbjct: 145 RRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVAL 204
Query: 195 LEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEK 254
+E +GR+G VW+ E VAVKIF +D+QSW E E+Y+ ++H+NIL FI ++
Sbjct: 205 VECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDM 264
Query: 255 RGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGH 314
+ LWLIT +HE GSL DFL+ + + +A + A GLA+LH +I G +
Sbjct: 265 TSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG-- 322
Query: 315 KPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLE 372
KPAI+HRD KS+NVL+K+NL CIAD GLA+ G D + +VGT+RYMAPEVL+
Sbjct: 323 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 382
Query: 373 GAINFQ-RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEV 431
I +++ D++A GLVLWE+A R T +G V++Y PF + + PS EDM++V
Sbjct: 383 EQIRTDCFESYKWTDIWAFGLVLWEIARR-TIVNGIVEDYRPPFYDVVPNDPSFEDMKKV 441
Query: 432 VVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 472
V ++ P + + ++ L + + ECW + ARL+A
Sbjct: 442 VCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA 482
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 214 bits (544), Expect = 2e-55
Identities = 139/401 (34%), Positives = 214/401 (53%), Gaps = 39/401 (9%)
Query: 104 CCEGNMCNEKFSYFPEMEVTQPTSN-PVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYR 162
CC+ ++CN S +E TQP S P T ++L ++ L+ + + + W R
Sbjct: 89 CCDSHLCNHNVSLV--LEATQPPSEQPGTDGQ--LALILGPVLALLALVALGVLGLWHVR 144
Query: 163 ---------HHKMAYPPVLVPTQDPGPPPPSPLL----------GL---------KPLQL 194
H ++ +++ + G LL GL + + L
Sbjct: 145 RRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVAL 204
Query: 195 LEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEK 254
+E +GR+G VW+ E VAVKIF +D+QSW E E+Y+ ++H+NIL FI ++
Sbjct: 205 VECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDM 264
Query: 255 RGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGH 314
+ LWLIT +HE GSL DFL+ + + +A + A GLA+LH +I G +
Sbjct: 265 TSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQG-- 322
Query: 315 KPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLE 372
KPAI+HRD KS+NVL+K+NL CIAD GLA+ G D + +VGT+RYMAPEVL+
Sbjct: 323 KPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLD 382
Query: 373 GAINFQ-RDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEV 431
I +++ D++A GLVLWE+A R T +G V++Y PF + + PS EDM++V
Sbjct: 383 EQIRTDCFESYKWTDIWAFGLVLWEIARR-TIVNGIVEDYRPPFYDVVPNDPSFEDMKKV 441
Query: 432 VVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 472
V ++ P + + ++ L + + ECW + ARL+A
Sbjct: 442 VCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTA 482
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 207 bits (527), Expect = 2e-53
Identities = 133/392 (33%), Positives = 210/392 (53%), Gaps = 46/392 (11%)
Query: 91 CVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPP--YYNILLYSLV--P 146
C+ +D + CC + CN +++ P+ + P+ P + + L ++ P
Sbjct: 84 CLSSEDLRNTH--CCYTDYCNR-------IDLRVPSGHLKEPEHPSMWGPVELVGIIAGP 134
Query: 147 LMLIAGIVICAFWVYRHHKMAYPP-VLVPTQDP----------------------GPPPP 183
+ L+ I+I F V +H+ Y + +DP G
Sbjct: 135 VFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSG 194
Query: 184 SPLLG----LKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLP 239
PL + + L E+ +GRFG VW+ + VAVKIF ++++SW E E+Y
Sbjct: 195 LPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTV 254
Query: 240 GMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARG 299
++HENIL FI A+ + LWL++ +HE GSL D+L V+ + +A + A G
Sbjct: 255 MLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASG 314
Query: 300 LAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--TH 357
LA+LH +I G + KP I+HRD+KSKN+L+K N IAD GLA++ +A D +
Sbjct: 315 LAHLHMEIVGTQG--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPN 372
Query: 358 GQVGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFE 416
+VGT+RYMAPEVL+ IN + D+F D+YA+GLV WE+A RC + G +EY LP+
Sbjct: 373 QRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSG-GVHEEYQLPYY 431
Query: 417 EEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKH 448
+ + PS+E+M++VV +K RP + ++WQ +
Sbjct: 432 DLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSY 463
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 203 bits (517), Expect = 3e-52
Identities = 148/493 (30%), Positives = 233/493 (47%), Gaps = 48/493 (9%)
Query: 30 CLFFNANWEKDRTNQTGVEPCYGDKDKR-------RHCFATWKNISGSIEIVKQGCWLDD 82
C+FF A + T G G + R R CF W ++ QGC D
Sbjct: 24 CVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRCCFGIWNLTQDRAQVEMQGCRDSD 83
Query: 83 ------INCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTP---- 132
++C D + ++ C C + CN +S+ P P +P TP
Sbjct: 84 EPGCESLHC-DPSPRAHPSPGSTLFTCSCGTDFCNANYSHLP------PPGSPGTPGSQG 136
Query: 133 --KPPYYNI-----LLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSP 185
P +I LL + L+L+ G +I A +++++ PV P D G
Sbjct: 137 PQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGEPVPEPRPDSGRDWSVE 196
Query: 186 LLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHEN 245
L L L +V G VW QL + VA+K FP + +Q E +Y LPG++H++
Sbjct: 197 LQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDH 256
Query: 246 ILQFIGAEKRGTS-VDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLH 304
I++FI A + G + L+ H KGSL +L W +A ++A+GLA+LH
Sbjct: 257 IVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLH 316
Query: 305 EDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEA-----GKSAGDTHG- 358
E+ +KP I+HRD+ S+NVL++ + + I D GLAL + G
Sbjct: 317 EE-RWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGP 375
Query: 359 ----QVGTRRYMAPEVLEGAINFQ--RDAFLRIDMYAMGLVLWELASRC--TAADGPVDE 410
+ GT+RYMAPE+L+ ++ Q A R D+Y++ L+LWE+ SRC D
Sbjct: 376 AAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPP 435
Query: 411 YMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHA-GMAMLCETIEECWDHDAEAR 469
+ L +E E+G P+ +++ + V +++RP + W+ A L E +E+CWD D EAR
Sbjct: 436 FQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPEAR 495
Query: 470 LSAGCVGERITQM 482
L+A CV +R+ +
Sbjct: 496 LTAECVQQRLAAL 508
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 176 bits (446), Expect = 5e-44
Identities = 117/347 (33%), Positives = 181/347 (52%), Gaps = 45/347 (12%)
Query: 91 CVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPP--YYNILLYSLV--P 146
C+ +D + CC + CN +++ P+ + P+ P + + L ++ P
Sbjct: 84 CLSSEDLRNTH--CCYTDYCNR-------IDLRVPSGHLKEPEHPSMWGPVELVGIIAGP 134
Query: 147 LMLIAGIVICAFWVYRHHKMAYPP-VLVPTQDP----------------------GPPPP 183
+ L+ I+I F V +H+ Y + +DP G
Sbjct: 135 VFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSG 194
Query: 184 SPLLG----LKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLP 239
PL + + L E+ +GRFG VW+ + VAVKIF ++++SW E E+Y
Sbjct: 195 LPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTV 254
Query: 240 GMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARG 299
++HENIL FI A+ + LWL++ +HE GSL D+L V+ + +A + A G
Sbjct: 255 MLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASG 314
Query: 300 LAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--TH 357
LA+LH +I G + KP I+HRD+KSKN+L+K N IAD GLA++ +A D +
Sbjct: 315 LAHLHMEIVGTQG--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPN 372
Query: 358 GQVGTRRYMAPEVLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTA 403
+VGT+RYMAPEVL+ IN + D+F D+YA+GLV WE+A RC +
Sbjct: 373 QRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS 419
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 174 bits (442), Expect = 1e-43
Identities = 93/223 (41%), Positives = 148/223 (66%), Gaps = 6/223 (2%)
Query: 263 LWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRD 322
LWL++ +HE+GSL D+L N+V+ + +A ++A GLA+LH +I G + KPAI+HRD
Sbjct: 109 LWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQG--KPAIAHRD 166
Query: 323 IKSKNVLLKNNLTACIADFGLALKFEAGKSAGDT--HGQVGTRRYMAPEVLEGAINFQR- 379
IKSKN+L+K T IAD GLA+K ++ + D + +VGT+RYMAPE+L+ +N
Sbjct: 167 IKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIF 226
Query: 380 DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRP 439
++F R D+Y++GLV WE+A RC+ G V+EY LP+ + + PS+E+M++VV +K RP
Sbjct: 227 ESFKRADIYSVGLVYWEIARRCSVG-GIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRP 285
Query: 440 VLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQM 482
+ + WQ + ++ + ECW + ARL+A + + I+Q+
Sbjct: 286 SIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 328
>gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo
sapiens]
Length = 518
Score = 108 bits (270), Expect = 1e-23
Identities = 94/298 (31%), Positives = 144/298 (48%), Gaps = 43/298 (14%)
Query: 183 PSPLLGLKPLQLLEVKARGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQNEYEVYSLPG 240
P+PL+ ++ L+ E+ +G FG V++AQ VAVKI S EV ++
Sbjct: 12 PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIV-----NSKAISREVKAMAS 66
Query: 241 MKHENILQFIGA-EKRGTSVDVDLWLITAFHEKGSLSDFLKANVVS-WNELCHIAETMAR 298
+ +E +L+ G EK D L+T F E GSLS L++ W LC + + +
Sbjct: 67 LDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVL 126
Query: 299 GLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHG 358
G+ YLH+ P + HRD+K NVLL L +ADFGL+ F+ G +G G
Sbjct: 127 GMFYLHDQ--------NPVLLHRDLKPSNVLLDPELHVKLADFGLS-TFQGGSQSGTGSG 177
Query: 359 QV-GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWE-LASRCTAADGPVDEYMLPFE 416
+ GT Y+APE+ +N R A D+Y+ G+++W LA R E
Sbjct: 178 EPGGTLGYLAPELF---VNVNRKASTASDVYSFGILMWAVLAGR---------------E 219
Query: 417 EEIGQHPSLEDMQEVVVHKKKRPVLRDYWQ---KHAGMAMLCETIEECWDHDAEARLS 471
E+ PSL + E V +++ RP L + Q + G+ L E ++ CW + + R S
Sbjct: 220 VELPTEPSL--VYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPS 275
>gi|223671888 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 97.4 bits (241), Expect = 3e-20
Identities = 80/238 (33%), Positives = 115/238 (48%), Gaps = 31/238 (13%)
Query: 201 GRFGCVWKAQLLNEYVAVKIFPIQ-----DKQSWQNEYEVYSLPGMKHENILQFIGAEKR 255
G FG V+K + N VAVK ++ Q + E+ + +HEN+++ +G
Sbjct: 71 GGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD 130
Query: 256 GTSVDVDLWLITAFHEKGSLSDFLKA----NVVSWNELCHIAETMARGLAYLHEDIPGLK 311
G DL L+ + GSL D L +SW+ C IA+ A G+ +LHE+
Sbjct: 131 GD----DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN----- 181
Query: 312 DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVL 371
H HRDIKS N+LL TA I+DFGLA E T VGT YMAPE L
Sbjct: 182 --HH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 236
Query: 372 EGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVD-EYMLPFEEEI-GQHPSLED 427
G I + D+Y+ G+VL E+ + A D + + +L +EEI + ++ED
Sbjct: 237 RGEIT------PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIED 288
>gi|223671885 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 97.4 bits (241), Expect = 3e-20
Identities = 80/238 (33%), Positives = 115/238 (48%), Gaps = 31/238 (13%)
Query: 201 GRFGCVWKAQLLNEYVAVKIFPIQ-----DKQSWQNEYEVYSLPGMKHENILQFIGAEKR 255
G FG V+K + N VAVK ++ Q + E+ + +HEN+++ +G
Sbjct: 71 GGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD 130
Query: 256 GTSVDVDLWLITAFHEKGSLSDFLKA----NVVSWNELCHIAETMARGLAYLHEDIPGLK 311
G DL L+ + GSL D L +SW+ C IA+ A G+ +LHE+
Sbjct: 131 GD----DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN----- 181
Query: 312 DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVL 371
H HRDIKS N+LL TA I+DFGLA E T VGT YMAPE L
Sbjct: 182 --HH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 236
Query: 372 EGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVD-EYMLPFEEEI-GQHPSLED 427
G I + D+Y+ G+VL E+ + A D + + +L +EEI + ++ED
Sbjct: 237 RGEIT------PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIED 288
>gi|223671883 interleukin-1 receptor-associated kinase 4 isoform b
[Homo sapiens]
Length = 336
Score = 97.4 bits (241), Expect = 3e-20
Identities = 80/238 (33%), Positives = 115/238 (48%), Gaps = 31/238 (13%)
Query: 201 GRFGCVWKAQLLNEYVAVKIFPIQ-----DKQSWQNEYEVYSLPGMKHENILQFIGAEKR 255
G FG V+K + N VAVK ++ Q + E+ + +HEN+++ +G
Sbjct: 71 GGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD 130
Query: 256 GTSVDVDLWLITAFHEKGSLSDFLKA----NVVSWNELCHIAETMARGLAYLHEDIPGLK 311
G DL L+ + GSL D L +SW+ C IA+ A G+ +LHE+
Sbjct: 131 GD----DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN----- 181
Query: 312 DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVL 371
H HRDIKS N+LL TA I+DFGLA E T VGT YMAPE L
Sbjct: 182 --HH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 236
Query: 372 EGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVD-EYMLPFEEEI-GQHPSLED 427
G I + D+Y+ G+VL E+ + A D + + +L +EEI + ++ED
Sbjct: 237 RGEIT------PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIED 288
>gi|166795293 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 97.4 bits (241), Expect = 3e-20
Identities = 80/238 (33%), Positives = 115/238 (48%), Gaps = 31/238 (13%)
Query: 201 GRFGCVWKAQLLNEYVAVKIFPIQ-----DKQSWQNEYEVYSLPGMKHENILQFIGAEKR 255
G FG V+K + N VAVK ++ Q + E+ + +HEN+++ +G
Sbjct: 195 GGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD 254
Query: 256 GTSVDVDLWLITAFHEKGSLSDFLKA----NVVSWNELCHIAETMARGLAYLHEDIPGLK 311
G DL L+ + GSL D L +SW+ C IA+ A G+ +LHE+
Sbjct: 255 GD----DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN----- 305
Query: 312 DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVL 371
H HRDIKS N+LL TA I+DFGLA E T VGT YMAPE L
Sbjct: 306 --HH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 360
Query: 372 EGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVD-EYMLPFEEEI-GQHPSLED 427
G I + D+Y+ G+VL E+ + A D + + +L +EEI + ++ED
Sbjct: 361 RGEIT------PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIED 412
>gi|166795295 interleukin-1 receptor-associated kinase 4 isoform a
[Homo sapiens]
Length = 460
Score = 97.4 bits (241), Expect = 3e-20
Identities = 80/238 (33%), Positives = 115/238 (48%), Gaps = 31/238 (13%)
Query: 201 GRFGCVWKAQLLNEYVAVKIFPIQ-----DKQSWQNEYEVYSLPGMKHENILQFIGAEKR 255
G FG V+K + N VAVK ++ Q + E+ + +HEN+++ +G
Sbjct: 195 GGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSD 254
Query: 256 GTSVDVDLWLITAFHEKGSLSDFLKA----NVVSWNELCHIAETMARGLAYLHEDIPGLK 311
G DL L+ + GSL D L +SW+ C IA+ A G+ +LHE+
Sbjct: 255 GD----DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHEN----- 305
Query: 312 DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVL 371
H HRDIKS N+LL TA I+DFGLA E T VGT YMAPE L
Sbjct: 306 --HH---IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 360
Query: 372 EGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVD-EYMLPFEEEI-GQHPSLED 427
G I + D+Y+ G+VL E+ + A D + + +L +EEI + ++ED
Sbjct: 361 RGEIT------PKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIED 412
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 87.4 bits (215), Expect = 3e-17
Identities = 63/214 (29%), Positives = 109/214 (50%), Gaps = 20/214 (9%)
Query: 193 QLLEVKARGRFGCVWKAQLLN--EYVAVKIFPIQDKQSWQNEYEVYSLPGMKHE-NILQF 249
+L+EV G +G V+K + + + A+K+ + + + + + E+ L H NI +
Sbjct: 26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATY 85
Query: 250 IGA--EKRGTSVDVDLWLITAFHEKGSLSDFLK---ANVVSWNELCHIAETMARGLAYLH 304
GA +K D LWL+ F GS++D +K N + + + +I + RGLA+LH
Sbjct: 86 YGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLH 145
Query: 305 EDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRR 364
HK + HRDIK +NVLL N + DFG++ + + ++ G + +GT
Sbjct: 146 --------AHK--VIHRDIKGQNVLLTENAEVKLVDFGVSAQLD--RTVGRRNTFIGTPY 193
Query: 365 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELA 398
+MAPEV+ N R D++++G+ E+A
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMA 227
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 87.4 bits (215), Expect = 3e-17
Identities = 63/214 (29%), Positives = 109/214 (50%), Gaps = 20/214 (9%)
Query: 193 QLLEVKARGRFGCVWKAQLLN--EYVAVKIFPIQDKQSWQNEYEVYSLPGMKHE-NILQF 249
+L+EV G +G V+K + + + A+K+ + + + + + E+ L H NI +
Sbjct: 26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATY 85
Query: 250 IGA--EKRGTSVDVDLWLITAFHEKGSLSDFLK---ANVVSWNELCHIAETMARGLAYLH 304
GA +K D LWL+ F GS++D +K N + + + +I + RGLA+LH
Sbjct: 86 YGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLH 145
Query: 305 EDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRR 364
HK + HRDIK +NVLL N + DFG++ + + ++ G + +GT
Sbjct: 146 --------AHK--VIHRDIKGQNVLLTENAEVKLVDFGVSAQLD--RTVGRRNTFIGTPY 193
Query: 365 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELA 398
+MAPEV+ N R D++++G+ E+A
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMA 227
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 87.4 bits (215), Expect = 3e-17
Identities = 63/214 (29%), Positives = 109/214 (50%), Gaps = 20/214 (9%)
Query: 193 QLLEVKARGRFGCVWKAQLLN--EYVAVKIFPIQDKQSWQNEYEVYSLPGMKHE-NILQF 249
+L+EV G +G V+K + + + A+K+ + + + + + E+ L H NI +
Sbjct: 26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATY 85
Query: 250 IGA--EKRGTSVDVDLWLITAFHEKGSLSDFLK---ANVVSWNELCHIAETMARGLAYLH 304
GA +K D LWL+ F GS++D +K N + + + +I + RGLA+LH
Sbjct: 86 YGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLH 145
Query: 305 EDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRR 364
HK + HRDIK +NVLL N + DFG++ + + ++ G + +GT
Sbjct: 146 --------AHK--VIHRDIKGQNVLLTENAEVKLVDFGVSAQLD--RTVGRRNTFIGTPY 193
Query: 365 YMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELA 398
+MAPEV+ N R D++++G+ E+A
Sbjct: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMA 227
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,901,816
Number of Sequences: 37866
Number of extensions: 1050986
Number of successful extensions: 6553
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 424
Number of HSP's successfully gapped in prelim test: 315
Number of HSP's that attempted gapping in prelim test: 5335
Number of HSP's gapped (non-prelim): 916
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.