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Search of human proteins with 44889475
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
(1287 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 2612 0.0
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 1856 0.0
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 134 7e-31
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 127 7e-29
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 127 7e-29
gi|239735519 SET binding factor 1 [Homo sapiens] 105 4e-22
gi|29788755 SET binding factor 2 [Homo sapiens] 101 4e-21
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 100 7e-21
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 89 3e-17
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 88 5e-17
gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens] 88 5e-17
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 84 7e-16
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 84 7e-16
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 84 7e-16
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 76 2e-13
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 74 7e-13
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 73 2e-12
gi|209863002 MAP-kinase activating death domain-containing prote... 72 3e-12
gi|209862998 MAP-kinase activating death domain-containing prote... 72 3e-12
gi|209862994 MAP-kinase activating death domain-containing prote... 72 3e-12
gi|18860873 MAP-kinase activating death domain-containing protei... 72 3e-12
gi|209862987 MAP-kinase activating death domain-containing prote... 72 3e-12
gi|209862983 MAP-kinase activating death domain-containing prote... 72 3e-12
gi|209862979 MAP-kinase activating death domain-containing prote... 72 3e-12
gi|209862975 MAP-kinase activating death domain-containing prote... 72 3e-12
gi|209862971 MAP-kinase activating death domain-containing prote... 72 3e-12
gi|209571517 MAP-kinase activating death domain-containing prote... 72 3e-12
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 71 8e-12
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 65 3e-10
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 65 4e-10
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 2612 bits (6770), Expect = 0.0
Identities = 1287/1287 (100%), Positives = 1287/1287 (100%)
Query: 1 MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTE 60
MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTE
Sbjct: 1 MSGGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTE 60
Query: 61 GENFEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAF 120
GENFEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAF
Sbjct: 61 GENFEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAF 120
Query: 121 IITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDG 180
IITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDG
Sbjct: 121 IITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDG 180
Query: 181 EDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPL 240
EDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPL
Sbjct: 181 EDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPL 240
Query: 241 ESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQ 300
ESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQ
Sbjct: 241 ESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQ 300
Query: 301 LFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYL 360
LFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYL
Sbjct: 301 LFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYL 360
Query: 361 MGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGI 420
MGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGI
Sbjct: 361 MGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGI 420
Query: 421 PPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTG 480
PPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTG
Sbjct: 421 PPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTG 480
Query: 481 VSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQ 540
VSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQ
Sbjct: 481 VSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQ 540
Query: 541 DKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPV 600
DKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPV
Sbjct: 541 DKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPV 600
Query: 601 LRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAIHPHLLDMKI 660
LRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAIHPHLLDMKI
Sbjct: 601 LRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAIHPHLLDMKI 660
Query: 661 GQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYI 720
GQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYI
Sbjct: 661 GQGKYEPGFFPKLQSDVLSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREKYI 720
Query: 721 QEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHG 780
QEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHG
Sbjct: 721 QEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVELGHG 780
Query: 781 EVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTS 840
EVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTS
Sbjct: 781 EVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSLSTS 840
Query: 841 GILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRH 900
GILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRH
Sbjct: 841 GILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLLSRH 900
Query: 901 LKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILI 960
LKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILI
Sbjct: 901 LKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYHILI 960
Query: 961 VPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGL 1020
VPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGL
Sbjct: 961 VPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDNSGL 1020
Query: 1021 YAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVDERPCRTP 1080
YAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVDERPCRTP
Sbjct: 1021 YAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVDERPCRTP 1080
Query: 1081 PLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGE 1140
PLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGE
Sbjct: 1081 PLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSLTLLLCGE 1140
Query: 1141 CGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCR 1200
CGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCR
Sbjct: 1141 CGLVSALEQAFQHGFKSPRLFKNVFIWDFLEKAQTYYETLEKNEVVPEENWHTRARNFCR 1200
Query: 1201 FVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLV 1260
FVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLV
Sbjct: 1201 FVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMYEDVALIKDHTLV 1260
Query: 1261 NSLIRVLQTLQEFNITLETSLVKGIDI 1287
NSLIRVLQTLQEFNITLETSLVKGIDI
Sbjct: 1261 NSLIRVLQTLQEFNITLETSLVKGIDI 1287
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 1856 bits (4807), Expect = 0.0
Identities = 918/1299 (70%), Positives = 1077/1299 (82%), Gaps = 47/1299 (3%)
Query: 3 GGGGGGGSAPSRFADYFVICGLDTETGLEPDELSALCQYIQASKARDGASPFISSTTEGE 62
G G G A RFA YFV+CG+D ++GLEPDEL+ GE
Sbjct: 9 GPGSGSSPAACRFAHYFVLCGIDADSGLEPDELA------------------------GE 44
Query: 63 NFEQTPLRRTFKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFII 122
NF+Q+PLRRTFKSKVLA YP+N+EWNPFDQDAV MLCMPKGL+F+TQ D ++PQFH+FII
Sbjct: 45 NFDQSPLRRTFKSKVLAHYPQNIEWNPFDQDAVNMLCMPKGLSFRTQTDNKDPQFHSFII 104
Query: 123 TREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAE-YDVLHAPPADDRDQ--SSMED 179
TREDGSRT+GF LTFYEEVTSKQIC+AMQTLY MHNAE Y ++A + D SS+++
Sbjct: 105 TREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEHYSSVYASSSCSMDSLASSLDE 164
Query: 180 GEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLP 239
G+ T + KLQR+NSYDISRDTLYVSK ICLITP+ FM+AC+ L QL++AVTS QPPPLP
Sbjct: 165 GDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLP 224
Query: 240 LESYIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVF 299
LESYI+N+LYEVPLPPPGRSLKF GVY P+ICQRP +ELPL D+P++E FELLG+EN+
Sbjct: 225 LESYIHNILYEVPLPPPGRSLKFYGVYEPVICQRPGPSELPLSDYPLREAFELLGLENLV 284
Query: 300 QLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPY 359
Q+FTC LLE QILLYSQ YQRLMTVAE IT L+FPFQWQHVYVPILPASLLHFLDAPVPY
Sbjct: 285 QVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPY 344
Query: 360 LMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFG 419
LMGL S DRSKLELPQEANLCFVDIDNHFIELPE+ PQFPNK++F+QE+SE+L+ FG
Sbjct: 345 LMGLQSKEGTDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFG 404
Query: 420 IPPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRT 479
IPPEG+LHCSES SKLK + +LV+DK+NGN+ + + YELLK NETIARLQAL KRT
Sbjct: 405 IPPEGSLHCSESTSKLKNMVLKDLVNDKKNGNVCTNNISMYELLKGNETIARLQALAKRT 464
Query: 480 GVSLEKLEVRED-PSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQP 538
GV++EK+++ +KDLK+ C+E ELR YQLN+Q+REVFANRFTQMFADYE FVIQ
Sbjct: 465 GVAVEKMDLSASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQT 524
Query: 539 SQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKD 598
+QD ESW TNREQMQNFDKASFLSDQPEPYLPFLSRF+ETQMFA+FIDNKIM ++KD
Sbjct: 525 AQDMESWLTNREQMQNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIM-SQWEEKD 583
Query: 599 PVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKIDHTAIHPHLLDM 658
P+LRVFD+R+DKIRL NVR PTLRTS+YQKC+T+ EA ++IE RL K+DHTAIHPHLLDM
Sbjct: 584 PLLRVFDTRIDKIRLYNVRAPTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDM 643
Query: 659 KIGQGKYEPGFFPKLQSDVLSTGPAS-NKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQRE 717
KIGQGKYE GFFPKLQSDVL+TGP S N+W R+A AQ RRK+R +QH+EH+ LDND RE
Sbjct: 644 KIGQGKYEQGFFPKLQSDVLATGPTSNNRWVSRSATAQ-RRKERLRQHSEHVGLDNDLRE 702
Query: 718 KYIQEARTMGSTIRQPKLSNLSPSVIAQTNWKFVEGLLKECRNKTKRMLVEKMGREAVEL 777
KY+QEAR++G +RQPKLS+LSP+VIAQTN KFVEGLLKECR KTKRMLVEKMG EAVEL
Sbjct: 703 KYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLLKECRMKTKRMLVEKMGHEAVEL 762
Query: 778 GHGEVNITGVEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLLHYQDNRQRKLTSGSL 837
GHGE NITG+EENTLIASLCDLLERIWSHGLQVKQGKSALWSHL+ +QD +++ L
Sbjct: 763 GHGEANITGLEENTLIASLCDLLERIWSHGLQVKQGKSALWSHLIQFQDREEKQ---EHL 819
Query: 838 STSGILLDSERRKSDASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRLSMEKKLL 897
+ S + L ERRKSD+ ++P LR+SLIQDMRHIQN+ EIKTDVG+ARAW+RLS+EKKLL
Sbjct: 820 AESPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMSEIKTDVGRARAWIRLSLEKKLL 879
Query: 898 SRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIPYH 957
S+HLKQLLS+ LTKKLYKRYAFLRC++E+EQFLYHLLS NAVDYFCFT+VFTTI+IPY
Sbjct: 880 SQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLYHLLSLNAVDYFCFTSVFTTIMIPYR 939
Query: 958 ILIVPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTFECQNLGKLTTVQIGHDN 1017
+I+P KKL ++ T+NPWIC+SGELG+T +MQIP+N+LEMTFECQNLGKLTTVQIGHDN
Sbjct: 940 SVIIPIKKLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFECQNLGKLTTVQIGHDN 999
Query: 1018 SGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGELLTSQPEVD-ERP 1076
SGL AKWLV+ VMVRNEITGHTY+FPCGRWLGKG+DDGSLERIL+GEL+TS + D +
Sbjct: 1000 SGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERILIGELMTSASDEDLVKQ 1059
Query: 1077 CRTPPLQQSPSVIRRLVTIS---PNNKPKLNTGQIQESIGEAVNGIVKHFHKPEKERGSL 1133
CRTPP Q+SP+ RRL S NNKP N GQIQE IGEAVN IVKHFHKPEKERGSL
Sbjct: 1060 CRTPPQQKSPTTARRLSITSLTGKNNKP--NAGQIQEGIGEAVNNIVKHFHKPEKERGSL 1117
Query: 1134 TLLLCGECGLVSALEQAFQHGFKSPRLF-KNVFIWDFLEKAQTYYETLEKNEVVPEEN-- 1190
T+LLCGE GLV+ALEQ F HGFKS R+F KNVFIWDF+EK Y+ET + +++ E+
Sbjct: 1118 TVLLCGENGLVAALEQVFHHGFKSARIFHKNVFIWDFIEKVVAYFETTD--QILDNEDDV 1175
Query: 1191 --WHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLADCPITAHMY 1248
+ + FC +V AIN PRNIGKDGKFQ+LVCLG RD LL WI LLA+CP MY
Sbjct: 1176 LIQKSSCKTFCHYVNAINTAPRNIGKDGKFQILVCLGTRDRLLPQWIPLLAECPAITRMY 1235
Query: 1249 EDVALIKDHTLVNSLIRVLQTLQEFNITLETSLVKGIDI 1287
E+ AL++D VNSLIR+LQT+Q+F I LE SL+KG+D+
Sbjct: 1236 EESALLRDRMTVNSLIRILQTIQDFTIVLEGSLIKGVDV 1274
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 134 bits (336), Expect = 7e-31
Identities = 155/620 (25%), Positives = 246/620 (39%), Gaps = 141/620 (22%)
Query: 115 PQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQ 174
P F F++T + +G A+ FYE S+++ S Q L H+
Sbjct: 17 PVFSTFVLTGSSAKKVYGAAIQFYEPY-SRELLSEKQ-LMHL------------------ 56
Query: 175 SSMEDGEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQ 234
G TPV + S + +KCICL++ F +A R L +++ S
Sbjct: 57 -----GLLTPVERKMVSKSIN-------TNKCICLLSHWPFFEAFRKFLMFIYKLSVSG- 103
Query: 235 PPPLPLESYIYNVLYEVPLPPPGRS--LKFSGVYGPIICQRPSTNELPLFDFPVKEVFEL 292
P PLP+E +I + + +P P P R L V+ +I +P + LPL +
Sbjct: 104 PHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMN 163
Query: 293 LGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHF 352
LG EN L LLE +ILL+S L VAE + A++FPFQWQ Y+P+ P SL
Sbjct: 164 LGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAV 223
Query: 353 LDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED-----LPQFPNKLEF 407
L AP+P+++G+ S D L P + +C +D+D + + + ++ Q P K
Sbjct: 224 LSAPLPFIVGVDSRYFD----LHDPPQDVVC-IDLDTNMLYVSDEKKNMNWKQLPKK--- 275
Query: 408 VQEVSEILMAFGIPPEGNLHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENE 467
C S LK+L
Sbjct: 276 -------------------PCKNLLSTLKKL----------------------------- 287
Query: 468 TIARLQALVKRT--GVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFT 525
+L ++ ++T G +++ + D S K ++ QL ++I+E F
Sbjct: 288 -YPQLSSVHQKTQEGSAIDMTPIEADFSWQK-----------KMTQLEMEIQEAFLRFMA 335
Query: 526 QMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFI 585
+ Y ++ ++ + T + + FD+ FL + Y F + +TQ+F FI
Sbjct: 336 SILKGYRTYLRPITEAPSNKATAADSL--FDRQGFLKSRDRAYAKFYTLLSKTQIFIRFI 393
Query: 586 DNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAE--KAIEL-R 642
+ C DKD L FD ++K+ P T K D AE + IEL
Sbjct: 394 EE---CSFVSDKDTGLAFFDDCIEKL------FPDKGTEKTDK-VDFDSAEDTRLIELDD 443
Query: 643 LAKIDHTAI----HPHLLDMKIGQGKYEPGFFPKLQSDV----------LSTGPASNKWT 688
K +HT P D K KY +FP+L + S P N T
Sbjct: 444 SQKSEHTVFIMPPEPPPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLCFSRHPTGNSIT 503
Query: 689 KRNAPAQWRRKDRQKQHTEH 708
K +P ++ +Q+ T H
Sbjct: 504 K--SPPLMAKRTKQEIKTAH 521
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 127 bits (319), Expect = 7e-29
Identities = 151/664 (22%), Positives = 263/664 (39%), Gaps = 150/664 (22%)
Query: 72 TFKSKVLARYPENVEWNPFD-QDAVGMLCMPKGLAFKTQADPRE---PQFHAFIITREDG 127
++K+ ++ RYP+ ++ F ++V + C+P G + + P F F++T
Sbjct: 207 SYKAGLICRYPQE-DYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
Query: 128 SRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTK 187
+ +G A+ FYE + + + + L L AD + SS
Sbjct: 266 EKVYGAAIQFYEPYSEENLTEKQRLL----------LGLTSADGKSDSSK---------- 305
Query: 188 LQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNV 247
T++ +KCICL++ F A R L L++ S P LP+E +I +
Sbjct: 306 ------------TIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISG-PHVLPIEKHISHF 352
Query: 248 LYEVPLPPPGRS--LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCA 305
+++VP P P R L + +I +P ++ LPL + + LG EN L A
Sbjct: 353 MHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFA 412
Query: 306 LLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHS 365
+ E +IL++S L +V E + +++FPF W YVP+ P +L L AP P+++G+ S
Sbjct: 413 VTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDS 472
Query: 366 NGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGN 425
D L P C VD+D + I D +A+ I P+
Sbjct: 473 RYFD----LYDPPPDVSC-VDVDTNTISQIGDKKN---------------VAWKILPK-- 510
Query: 426 LHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEK 485
C + L L ++ +A+LQ + G L
Sbjct: 511 KPCKNLMNTLNNL---------------------------HQQLAKLQQRPRDDG--LMD 541
Query: 486 LEVRE-DPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKES 544
L + + D +S K L + ++++I+E F + Y ++ +Q
Sbjct: 542 LAINDYDFNSGKRL-----------HMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSE 590
Query: 545 WFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVF 604
T+ + F +FL + + F + +TQMF FI+ C DKD L F
Sbjct: 591 TATDAASL--FALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEE---CSFVSDKDASLAFF 645
Query: 605 DSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKID------HTAI-----HP 653
D VDK+ + +K+ E+RL ++D HT P
Sbjct: 646 DDCVDKV----------------------DMDKSGEVRLIELDESFKSEHTVFVTPPEIP 683
Query: 654 HLLDMKIGQGKYEPGFFPKLQSDVL---------STGPASNKWTKRNAPAQWRRKDRQKQ 704
HL + + +Y FP L++++ +K + N+P R+ +Q+
Sbjct: 684 HLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKNKLPSKSSSPNSPLPMFRRTKQEI 743
Query: 705 HTEH 708
+ H
Sbjct: 744 KSAH 747
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 127 bits (319), Expect = 7e-29
Identities = 151/664 (22%), Positives = 263/664 (39%), Gaps = 150/664 (22%)
Query: 72 TFKSKVLARYPENVEWNPFD-QDAVGMLCMPKGLAFKTQADPRE---PQFHAFIITREDG 127
++K+ ++ RYP+ ++ F ++V + C+P G + + P F F++T
Sbjct: 207 SYKAGLICRYPQE-DYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASA 265
Query: 128 SRTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTK 187
+ +G A+ FYE + + + + L L AD + SS
Sbjct: 266 EKVYGAAIQFYEPYSEENLTEKQRLL----------LGLTSADGKSDSSK---------- 305
Query: 188 LQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNV 247
T++ +KCICL++ F A R L L++ S P LP+E +I +
Sbjct: 306 ------------TIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISG-PHVLPIEKHISHF 352
Query: 248 LYEVPLPPPGRS--LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCA 305
+++VP P P R L + +I +P ++ LPL + + LG EN L A
Sbjct: 353 MHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFA 412
Query: 306 LLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHS 365
+ E +IL++S L +V E + +++FPF W YVP+ P +L L AP P+++G+ S
Sbjct: 413 VTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDS 472
Query: 366 NGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGN 425
D L P C VD+D + I D +A+ I P+
Sbjct: 473 RYFD----LYDPPPDVSC-VDVDTNTISQIGDKKN---------------VAWKILPK-- 510
Query: 426 LHCSESASKLKRLRASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEK 485
C + L L ++ +A+LQ + G L
Sbjct: 511 KPCKNLMNTLNNL---------------------------HQQLAKLQQRPRDDG--LMD 541
Query: 486 LEVRE-DPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKES 544
L + + D +S K L + ++++I+E F + Y ++ +Q
Sbjct: 542 LAINDYDFNSGKRL-----------HMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSE 590
Query: 545 WFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVF 604
T+ + F +FL + + F + +TQMF FI+ C DKD L F
Sbjct: 591 TATDAASL--FALQAFLRSRDRSHQKFYNMMTKTQMFIRFIEE---CSFVSDKDASLAFF 645
Query: 605 DSRVDKIRLLNVRTPTLRTSMYQKCTTVDEAEKAIELRLAKID------HTAI-----HP 653
D VDK+ + +K+ E+RL ++D HT P
Sbjct: 646 DDCVDKV----------------------DMDKSGEVRLIELDESFKSEHTVFVTPPEIP 683
Query: 654 HLLDMKIGQGKYEPGFFPKLQSDVL---------STGPASNKWTKRNAPAQWRRKDRQKQ 704
HL + + +Y FP L++++ +K + N+P R+ +Q+
Sbjct: 684 HLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKNKLPSKSSSPNSPLPMFRRTKQEI 743
Query: 705 HTEH 708
+ H
Sbjct: 744 KSAH 747
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 105 bits (261), Expect = 4e-22
Identities = 88/343 (25%), Positives = 148/343 (43%), Gaps = 48/343 (13%)
Query: 74 KSKVLARYPENVEW--NPFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTF 131
+ ++L R+PE +W NPF Q + + C P G + +P P F ++T + R +
Sbjct: 24 QGQILQRFPEK-DWEDNPFPQ-GIELFCQPSGWQLCPERNP--PTFFVAVLTDINSERHY 79
Query: 132 GFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGED-----TPVT 186
LTF+E Q + A +R++ E G+ P
Sbjct: 80 CACLTFWEPAEPSQ----------------ETTRVEDATEREEEGDEGGQTHLSPTAPAP 123
Query: 187 KLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYN 246
Q L+ K + L++ + + R+ L ++ + + LE+ I N
Sbjct: 124 SAQ-----------LFAPKTLVLVSRLDHTEVFRNSLGLIY--AIHVEGLNVCLENVIGN 170
Query: 247 VLY-EVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCA 305
+L VPL + G + Q P + LP+ V +F LG+ NV LF A
Sbjct: 171 LLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAA 230
Query: 306 LLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHS 365
L E ++L S+ YQRL + AL+FP ++ YVPILPA LL L P P+++G+++
Sbjct: 231 LTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNA 290
Query: 366 NGLDDRSKLELPQEANLCFVDIDNHFIELPE--DLPQFPNKLE 406
+ E + ++ D+D + +PE +P P L+
Sbjct: 291 -----AFQAETQELLDVIVADLDGGTVTIPECVHIPPLPEPLQ 328
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 101 bits (252), Expect = 4e-21
Identities = 85/325 (26%), Positives = 149/325 (45%), Gaps = 50/325 (15%)
Query: 76 KVLARYPENVEWN--PFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGF 133
K++ R+P+ +W+ PF Q + + C P G ++ + ++P F ++T D R +
Sbjct: 26 KIIQRFPQK-DWDDTPFPQ-GIELFCQPGG--WQLSRERKQPTFFVVVLTDIDSDRHYCS 81
Query: 134 ALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQRFNS 193
LTFYE AE + L ++ + + G P
Sbjct: 82 CLTFYE-------------------AEIN-LQGTKKEEIEGEAKVSGLIQPAE------- 114
Query: 194 YDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPL 253
++ K + L++ + + + R+ L ++ + LES I N L +
Sbjct: 115 -------VFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLN--VSLESLIAN-LCACLV 164
Query: 254 PPPGRSLK-FS-GVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQI 311
P G S K FS G + Q P + LP+ V +F+ LG++NV LF L E ++
Sbjct: 165 PAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKV 224
Query: 312 LLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDR 371
L +S +QRL + +LMFP ++ + Y+PILPA LL L +P P+++G+HS
Sbjct: 225 LFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHS-----V 279
Query: 372 SKLELPQEANLCFVDIDNHFIELPE 396
K ++ + ++ D+D I++PE
Sbjct: 280 FKTDVHELLDVIIADLDGGTIKIPE 304
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 100 bits (250), Expect = 7e-21
Identities = 87/347 (25%), Positives = 151/347 (43%), Gaps = 51/347 (14%)
Query: 73 FKSKVLARYPENVEWNPFDQDAVGMLCMPKGLAFK---TQADPREPQFHAFIITREDGSR 129
+++++L RYPE ++V + C+P G + Q P F F++T G +
Sbjct: 211 YEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDK 270
Query: 130 TFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQ 189
+G AL FYE ++ + S++E G
Sbjct: 271 VYGAALQFYEAFPRARLSERQARALGL-----------------LSAVERGRA------- 306
Query: 190 RFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLY 249
+ + + I +++ A R+ L L++ S P LPLE++I + ++
Sbjct: 307 ------LGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSG-PHRLPLEAHISHFIH 359
Query: 250 EVPLPPPGRS---LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCAL 306
VP P P R ++ S ++CQ P ++ LPL ++ + LG E L L
Sbjct: 360 NVPFPSPQRPRILVQMSPYDNLLLCQ-PVSSPLPLSGASFLQLLQSLGPELAITLLLAVL 418
Query: 307 LEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSN 366
E ++L++S L +V E + +++FP WQ Y+P+ P L L APVP+++G+HS+
Sbjct: 419 TEHKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSS 478
Query: 367 GLDDRSKLELPQEANLCFVDIDNHF--------IELPEDLPQFPNKL 405
D L P +C VD+D + + P LP+ P K+
Sbjct: 479 YFD----LHDPPADVIC-VDLDTNTLFQTEEKKLLSPRTLPRRPYKV 520
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 89.0 bits (219), Expect = 3e-17
Identities = 82/328 (25%), Positives = 132/328 (40%), Gaps = 60/328 (18%)
Query: 98 LCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGFALTFYEEVTSKQICSAMQTLYHMH 157
LC P G+ T+ P+E H ++T G+RT+G +Y + + +T
Sbjct: 45 LCFPGGVCVATE--PKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKT----- 97
Query: 158 NAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMK 217
+ E P A V + RF Y+ +D L S + L+ P +
Sbjct: 98 HRECPGCFVPFA---------------VCVVSRFPYYNSLKDCL--SCLLALLKPCKDFE 140
Query: 218 ACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPP---PGRSLKFSGVYGPIICQRP 274
+ + + P PPP PL ++ LP P + ++ P++C RP
Sbjct: 141 VDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRP 200
Query: 275 STNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFP 334
E V Q+ TC L E +I+ +S + L V E A ++P
Sbjct: 201 ---------------------EKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYP 239
Query: 335 FQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIEL 394
QWQH +VPIL +L F+ AP +LMG H + ++ SK + L ++ID+ I
Sbjct: 240 LQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSK----EADGLVLINIDHGSITY 295
Query: 395 PE------DLPQFP--NKLEFVQEVSEI 414
+ D+P P F+Q V +
Sbjct: 296 SKSTDDNVDIPDVPLLAAQTFIQRVQSL 323
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 88.2 bits (217), Expect = 5e-17
Identities = 61/224 (27%), Positives = 106/224 (47%), Gaps = 15/224 (6%)
Query: 183 TPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLES 242
T + QRF +S C C+++ + + + +L L T Q +
Sbjct: 76 TDIDSKQRFGFCRLSSGA---KSCFCILSYLPWFEVFYKLLNILADYTTKRQENQW---N 129
Query: 243 YIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLF--DFPVKEVFELLGVENVFQ 300
+ L+++P+P PG S+ S V+ P T ELP + + E F + V N+
Sbjct: 130 ELLETLHKLPIPDPGVSVHLS-VHSYFTV--PDTRELPSIPENRNLTEYFVAVDVNNMLH 186
Query: 301 LFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYL 360
L+ L E +IL+ L A+++P WQHVY+P+LP LL + AP+PYL
Sbjct: 187 LYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYL 246
Query: 361 MGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELP-EDLPQFPN 403
+G+H + ++ + L ++ +++D + +E P +DL PN
Sbjct: 247 IGIHLSLMEKVRNMALD---DVVILNVDTNTLETPFDDLQSLPN 287
>gi|55749779 DENN/MADD domain containing 1A isoform 1 [Homo sapiens]
Length = 1009
Score = 88.2 bits (217), Expect = 5e-17
Identities = 61/224 (27%), Positives = 106/224 (47%), Gaps = 15/224 (6%)
Query: 183 TPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLES 242
T + QRF +S C C+++ + + + +L L T Q +
Sbjct: 76 TDIDSKQRFGFCRLSSGA---KSCFCILSYLPWFEVFYKLLNILADYTTKRQENQW---N 129
Query: 243 YIYNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLF--DFPVKEVFELLGVENVFQ 300
+ L+++P+P PG S+ S V+ P T ELP + + E F + V N+
Sbjct: 130 ELLETLHKLPIPDPGVSVHLS-VHSYFTV--PDTRELPSIPENRNLTEYFVAVDVNNMLH 186
Query: 301 LFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYL 360
L+ L E +IL+ L A+++P WQHVY+P+LP LL + AP+PYL
Sbjct: 187 LYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYL 246
Query: 361 MGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELP-EDLPQFPN 403
+G+H + ++ + L ++ +++D + +E P +DL PN
Sbjct: 247 IGIHLSLMEKVRNMALD---DVVILNVDTNTLETPFDDLQSLPN 287
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo
sapiens]
Length = 1137
Score = 84.3 bits (207), Expect = 7e-16
Identities = 48/168 (28%), Positives = 87/168 (51%), Gaps = 8/168 (4%)
Query: 248 LYEVPLPPPGRSLKFS----GVYGPII-CQRPSTNELPLFDFPVKEVFELLGVENVFQLF 302
L E P P PG+++K G ++ +RP + L DF +F L V + ++F
Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFEC--LFTCLSVRQLIRIF 890
Query: 303 TCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMG 362
LLE +++ + L + + + AL++PF WQH ++P+LPAS++ + P P+L+G
Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 950
Query: 363 LHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQE 410
L S+ L +L + +EA + + D ++ ++ P KL+ E
Sbjct: 951 LLSSSLPKLKELPV-EEALMVNLGSDRFIRQMDDEDTLLPRKLQAALE 997
Score = 35.4 bits (80), Expect = 0.35
Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 12/114 (10%)
Query: 475 LVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVF 534
L ++ +LE+ R++ ++D D+E LN + EVF F + Y +F
Sbjct: 988 LPRKLQAALEQALERKNELISQDSDSDSDDE---CNTLNGLVSEVFIRFFVETVGHYSLF 1044
Query: 535 VIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNK 588
+ Q + + ++ Q + F K S + FL F+E+QMFA FI ++
Sbjct: 1045 LTQSEKGERAF-----QREAFRK----SVASKSIRRFLEVFMESQMFAGFIQDR 1089
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo
sapiens]
Length = 1137
Score = 84.3 bits (207), Expect = 7e-16
Identities = 48/168 (28%), Positives = 87/168 (51%), Gaps = 8/168 (4%)
Query: 248 LYEVPLPPPGRSLKFS----GVYGPII-CQRPSTNELPLFDFPVKEVFELLGVENVFQLF 302
L E P P PG+++K G ++ +RP + L DF +F L V + ++F
Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFEC--LFTCLSVRQLIRIF 890
Query: 303 TCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMG 362
LLE +++ + L + + + AL++PF WQH ++P+LPAS++ + P P+L+G
Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 950
Query: 363 LHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQE 410
L S+ L +L + +EA + + D ++ ++ P KL+ E
Sbjct: 951 LLSSSLPKLKELPV-EEALMVNLGSDRFIRQMDDEDTLLPRKLQAALE 997
Score = 35.4 bits (80), Expect = 0.35
Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 12/114 (10%)
Query: 475 LVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVF 534
L ++ +LE+ R++ ++D D+E LN + EVF F + Y +F
Sbjct: 988 LPRKLQAALEQALERKNELISQDSDSDSDDE---CNTLNGLVSEVFIRFFVETVGHYSLF 1044
Query: 535 VIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNK 588
+ Q + + ++ Q + F K S + FL F+E+QMFA FI ++
Sbjct: 1045 LTQSEKGERAF-----QREAFRK----SVASKSIRRFLEVFMESQMFAGFIQDR 1089
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 84.3 bits (207), Expect = 7e-16
Identities = 48/168 (28%), Positives = 87/168 (51%), Gaps = 8/168 (4%)
Query: 248 LYEVPLPPPGRSLKFS----GVYGPII-CQRPSTNELPLFDFPVKEVFELLGVENVFQLF 302
L E P P PG+++K G ++ +RP + L DF +F L V + ++F
Sbjct: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDFEC--LFTCLSVRQLIRIF 470
Query: 303 TCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMG 362
LLE +++ + L + + + AL++PF WQH ++P+LPAS++ + P P+L+G
Sbjct: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLVG 530
Query: 363 LHSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQE 410
L S+ L +L + +EA + + D ++ ++ P KL+ E
Sbjct: 531 LLSSSLPKLKELPV-EEALMVNLGSDRFIRQMDDEDTLLPRKLQAALE 577
Score = 35.4 bits (80), Expect = 0.35
Identities = 30/114 (26%), Positives = 53/114 (46%), Gaps = 12/114 (10%)
Query: 475 LVKRTGVSLEKLEVREDPSSNKDLKVQCDEEELRIYQLNIQIREVFANRFTQMFADYEVF 534
L ++ +LE+ R++ ++D D+E LN + EVF F + Y +F
Sbjct: 568 LPRKLQAALEQALERKNELISQDSDSDSDDE---CNTLNGLVSEVFIRFFVETVGHYSLF 624
Query: 535 VIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPFLSRFLETQMFASFIDNK 588
+ Q + + ++ Q + F K S + FL F+E+QMFA FI ++
Sbjct: 625 LTQSEKGERAF-----QREAFRK----SVASKSIRRFLEVFMESQMFAGFIQDR 669
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 76.3 bits (186), Expect = 2e-13
Identities = 55/222 (24%), Positives = 103/222 (46%), Gaps = 12/222 (5%)
Query: 185 VTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYI 244
+T ++ + R T + C+C+++ + + + +L L + L +
Sbjct: 73 LTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAKELENDL---NET 129
Query: 245 YNVLYEVPLPPPGRSLKFSGVYGPIICQRPSTNELPLFDFP--VKEVFELLGVENVFQLF 302
LY P+P + S V+ I P LP + E F + V N+ QL+
Sbjct: 130 LRSLYNHPVPKANTPVNLS-VHSYFIA--PDVTGLPTIPESRNLTEYFVAVDVNNMLQLY 186
Query: 303 TCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMG 362
L E +I++ S L AL++P WQH+Y+P+LP LL + AP+PYL+G
Sbjct: 187 ASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIG 246
Query: 363 LHSNGLDDRSKLELPQEANLCFVDIDNHFIELP-EDLPQFPN 403
+HS+ ++ +++ ++ +++D + +E P DL P+
Sbjct: 247 IHSSLIE---RVKNKSLEDVVMLNVDTNTLESPFSDLNNLPS 285
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 74.3 bits (181), Expect = 7e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 19/219 (8%)
Query: 208 CLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPLPPPGRSLKFSGVYG 267
C+++ + +L+++ + + P + ++ +V+ E P P PGR++ Y
Sbjct: 535 CMVSRLGCFNLFSKILDEVEKR---REMSPALVYPFMRSVM-EAPFPAPGRTITVKS-YL 589
Query: 268 P------IICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQILLYSQHYQRL 321
P I RP + L DF K +F+ L V ++ ++ LLE +++ + L
Sbjct: 590 PGAGDESIELCRPLDSRLEHVDF--KCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTL 647
Query: 322 MTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEAN 381
+ A ++PF WQH Y+P+LPAS++ + +P P+L+G+ S L L + +E
Sbjct: 648 SKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPI-EEVL 706
Query: 382 LCFVDIDNHFIELPEDLPQFPNKL-----EFVQEVSEIL 415
+ + D E+ ++ P KL + ++E +EIL
Sbjct: 707 IVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEIL 745
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 73.2 bits (178), Expect = 2e-12
Identities = 37/117 (31%), Positives = 66/117 (56%), Gaps = 4/117 (3%)
Query: 288 EVFELLGVENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPA 347
E F + V N+ QL+ L E +I++ S L AL++P WQH+Y+P+LP
Sbjct: 192 EYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPP 251
Query: 348 SLLHFLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELP-EDLPQFPN 403
LL + AP+PYL+G+HS+ ++ +++ ++ +++D + +E P DL P+
Sbjct: 252 HLLDYCCAPMPYLIGIHSSLIE---RVKNKSLEDVVMLNVDTNTLESPFSDLNNLPS 305
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
Query: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
Query: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
Query: 406 EFVQEVSEILMAFGI 420
E + + + L + +
Sbjct: 423 ELKKHLKQALASMSL 437
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
Query: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
Query: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
Query: 406 EFVQEVSEILMAFGI 420
E + + + L + +
Sbjct: 423 ELKKHLKQALASMSL 437
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
Query: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
Query: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
Query: 406 EFVQEVSEILMAFGI 420
E + + + L + +
Sbjct: 423 ELKKHLKQALASMSL 437
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
Query: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
Query: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
Query: 406 EFVQEVSEILMAFGI 420
E + + + L + +
Sbjct: 423 ELKKHLKQALASMSL 437
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
Query: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
Query: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
Query: 406 EFVQEVSEILMAFGI 420
E + + + L + +
Sbjct: 423 ELKKHLKQALASMSL 437
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
Query: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
Query: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
Query: 406 EFVQEVSEILMAFGI 420
E + + + L + +
Sbjct: 423 ELKKHLKQALASMSL 437
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
Query: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
Query: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
Query: 406 EFVQEVSEILMAFGI 420
E + + + L + +
Sbjct: 423 ELKKHLKQALASMSL 437
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
Query: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
Query: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
Query: 406 EFVQEVSEILMAFGI 420
E + + + L + +
Sbjct: 423 ELKKHLKQALASMSL 437
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
Query: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
Query: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
Query: 406 EFVQEVSEILMAFGI 420
E + + + L + +
Sbjct: 423 ELKKHLKQALASMSL 437
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
Query: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
Query: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
Query: 406 EFVQEVSEILMAFGI 420
E + + + L + +
Sbjct: 423 ELKKHLKQALASMSL 437
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 70.9 bits (172), Expect = 8e-12
Identities = 50/168 (29%), Positives = 82/168 (48%), Gaps = 12/168 (7%)
Query: 250 EVPLPPPGRS------LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFT 303
E P P G++ L SG +C RP + L DF + +F L V ++ +F
Sbjct: 704 EAPFPALGKTILVKNFLPGSGTEVIELC-RPLDSRLEHVDF--ESLFSSLSVRHLVCVFA 760
Query: 304 CALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGL 363
LLE +++ + L + AL++PF WQH Y+P+LP +++ + +P P+L+GL
Sbjct: 761 SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGL 820
Query: 364 HSNGLDDRSKLELPQEANLCFVDIDNHFIELPEDLPQ-FPNKLEFVQE 410
S+ L ELP E L +++ F+ +D P KL+ E
Sbjct: 821 LSSSLP--LLRELPLEEVLVVDLVNSRFLRQMDDEDSILPRKLQVALE 866
Score = 31.6 bits (70), Expect = 5.1
Identities = 23/83 (27%), Positives = 35/83 (42%), Gaps = 9/83 (10%)
Query: 512 LNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYLPF 571
LN + E F F ++ Y +F+ S ++E RE + + L F
Sbjct: 895 LNEVVSEAFVRFFVEIVGHYSLFLT--SGEREERTLQREAFRKAVSSKSLRH-------F 945
Query: 572 LSRFLETQMFASFIDNKIMCHDD 594
L F+ETQMF FI + + D
Sbjct: 946 LEVFMETQMFRGFIQERELRRQD 968
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 65.5 bits (158), Expect = 3e-10
Identities = 38/117 (32%), Positives = 61/117 (52%), Gaps = 8/117 (6%)
Query: 253 LPPPGRSLKFSGVYGPIIC-QRPSTNELPLF--DFPVKEVFELLGVENVFQLFTCALLEF 309
+PPP R G P+ C P + LP + + E+ + EN+ LF L E
Sbjct: 161 IPPPTR-----GNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAER 215
Query: 310 QILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSN 366
++LL + L + AL++P +W+HV +P LP LL + AP+PYL+G+H++
Sbjct: 216 RVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHAS 272
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 65.1 bits (157), Expect = 4e-10
Identities = 35/121 (28%), Positives = 57/121 (47%), Gaps = 7/121 (5%)
Query: 248 LYEVPLPPPGRSLKFSGVYGP-----IICQRPSTNELPLFDFPVKEVFELLGVENVFQLF 302
L E P PG+++ I RP + L DF + L E + Q+F
Sbjct: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDF--SSLLHCLSFEQILQIF 248
Query: 303 TCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMG 362
A+LE +I+ ++ L AL++PF W H Y+P++P SLL + P P+++G
Sbjct: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVG 308
Query: 363 L 363
+
Sbjct: 309 V 309
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,619,551
Number of Sequences: 37866
Number of extensions: 2391879
Number of successful extensions: 7848
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 7633
Number of HSP's gapped (non-prelim): 192
length of query: 1287
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1173
effective length of database: 13,930,794
effective search space: 16340821362
effective search space used: 16340821362
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.