Guide to the Human Genome
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Search of human proteins with 126131093

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
         (624 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s...  1254   0.0  
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa...  1248   0.0  
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s...  1146   0.0  
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s...  1096   0.0  
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s...   521   e-148
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s...   521   e-148
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]         515   e-146
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom...   513   e-145
gi|4885583 Rho-associated, coiled-coil containing protein kinase...   366   e-101
gi|41872583 Rho-associated, coiled-coil containing protein kinas...   365   e-101
gi|32698688 citron [Homo sapiens]                                     335   1e-91
gi|24307971 serine/threonine kinase 38 like [Homo sapiens]            275   9e-74
gi|6005814 serine/threonine kinase 38 [Homo sapiens]                  274   2e-73
gi|150170729 microtubule associated serine/threonine kinase 3 [H...   217   3e-56
gi|112363080 microtubule associated serine/threonine kinase 2 [H...   215   9e-56
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho...   214   1e-55
gi|148727255 microtubule associated serine/threonine kinase fami...   211   1e-54
gi|28557781 protein kinase C, eta [Homo sapiens]                      200   4e-51
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   197   2e-50
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha...   197   3e-50
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho...   197   3e-50
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   196   7e-50
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph...   196   7e-50
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta...   196   7e-50
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ...   195   9e-50
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   189   9e-48
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is...   189   9e-48
gi|5453976 protein kinase C, theta [Homo sapiens]                     188   1e-47
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   187   2e-47
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is...   187   2e-47

>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
           sapiens]
          Length = 624

 Score = 1254 bits (3246), Expect = 0.0
 Identities = 624/624 (100%), Positives = 624/624 (100%)

Query: 1   MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
           MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR
Sbjct: 1   MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60

Query: 61  LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
           LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER
Sbjct: 61  LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120

Query: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
           DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV
Sbjct: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180

Query: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
           MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP
Sbjct: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240

Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
           EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP
Sbjct: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300

Query: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360
           LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG
Sbjct: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360

Query: 361 ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA 420
           ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA
Sbjct: 361 ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA 420

Query: 421 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 480
           EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL
Sbjct: 421 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 480

Query: 481 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD 540
           SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD
Sbjct: 481 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD 540

Query: 541 PPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALG 600
           PPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALG
Sbjct: 541 PPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALG 600

Query: 601 CIGLVAHAGQLTAVWRRPGAARAP 624
           CIGLVAHAGQLTAVWRRPGAARAP
Sbjct: 601 CIGLVAHAGQLTAVWRRPGAARAP 624


>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
           sapiens]
          Length = 629

 Score = 1248 bits (3230), Expect = 0.0
 Identities = 624/629 (99%), Positives = 624/629 (99%), Gaps = 5/629 (0%)

Query: 1   MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
           MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR
Sbjct: 1   MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60

Query: 61  LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
           LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER
Sbjct: 61  LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120

Query: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
           DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV
Sbjct: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180

Query: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
           MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP
Sbjct: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240

Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
           EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP
Sbjct: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300

Query: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360
           LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG
Sbjct: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360

Query: 361 ATDTCNFDLVEDGLTAM-----ETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP 415
           ATDTCNFDLVEDGLTAM     ETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP
Sbjct: 361 ATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP 420

Query: 416 MELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVL 475
           MELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVL
Sbjct: 421 MELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVL 480

Query: 476 TRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPS 535
           TRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPS
Sbjct: 481 TRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPS 540

Query: 536 PRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSR 595
           PRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSR
Sbjct: 541 PRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSR 600

Query: 596 AAALGCIGLVAHAGQLTAVWRRPGAARAP 624
           AAALGCIGLVAHAGQLTAVWRRPGAARAP
Sbjct: 601 AAALGCIGLVAHAGQLTAVWRRPGAARAP 629


>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
           sapiens]
          Length = 639

 Score = 1146 bits (2964), Expect = 0.0
 Identities = 571/576 (99%), Positives = 571/576 (99%), Gaps = 5/576 (0%)

Query: 54  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 113
           AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV
Sbjct: 64  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123

Query: 114 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 173
           SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR
Sbjct: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183

Query: 174 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 233
           FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG
Sbjct: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243

Query: 234 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 293
           TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY
Sbjct: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303

Query: 294 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
           KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP
Sbjct: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363

Query: 354 FTPDFEGATDTCNFDLVEDGLTAM-----ETLSDIREGAPLGVHLPFVGYSYSCMALRDS 408
           FTPDFEGATDTCNFDLVEDGLTAM     ETLSDIREGAPLGVHLPFVGYSYSCMALRDS
Sbjct: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDS 423

Query: 409 EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE 468
           EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE
Sbjct: 424 EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE 483

Query: 469 ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT 528
           ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT
Sbjct: 484 ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT 543

Query: 529 AVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLL 588
           AVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLL
Sbjct: 544 AVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLL 603

Query: 589 FAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP 624
           FAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
Sbjct: 604 FAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP 639


>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
           sapiens]
          Length = 625

 Score = 1096 bits (2835), Expect = 0.0
 Identities = 545/549 (99%), Positives = 546/549 (99%)

Query: 1   MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
           MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR
Sbjct: 1   MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60

Query: 61  LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
           LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER
Sbjct: 61  LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120

Query: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
           DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV
Sbjct: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180

Query: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
           MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP
Sbjct: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240

Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
           EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP
Sbjct: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300

Query: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360
           LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG
Sbjct: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360

Query: 361 ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA 420
           ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA
Sbjct: 361 ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA 420

Query: 421 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 480
           EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL
Sbjct: 421 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 480

Query: 481 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD 540
           SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD
Sbjct: 481 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD 540

Query: 541 PPSHLDGPP 549
           PPSH+   P
Sbjct: 541 PPSHMAPRP 549


>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
           sapiens]
          Length = 1719

 Score =  521 bits (1342), Expect = e-148
 Identities = 279/551 (50%), Positives = 374/551 (67%), Gaps = 34/551 (6%)

Query: 1   MSAEVRLRRLQQLVLDPGF------LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWA 54
           MS EVRLR+L+Q +LD           +E LLD+L+ ++ E   S L ++K + ++L+WA
Sbjct: 1   MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60

Query: 55  EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 114
           +P   ++K++RL R+DFEILKVIGRGAF EVAVVK+K   +V+AMKI+NKW+MLKR E +
Sbjct: 61  KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120

Query: 115 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 174
           CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MARF
Sbjct: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180

Query: 175 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 234
           YLAE+V+AIDSVH+L YVHRDIKPDNIL+D  GHIRLADFGSCLKL  DGTV+S VAVGT
Sbjct: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240

Query: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
           PDY+SPEILQA+    G G YGPECDWW+LGV  YEM YG+TPFYA+S  ETYGKI+++K
Sbjct: 241 PDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298

Query: 295 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
           E    P     V E A+D I+RL+C  E RLG+ G  DF+ HPFF G+DWD +R+   P+
Sbjct: 299 ERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPY 358

Query: 355 TPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY-SCMALRDSE---- 409
            P+    TDT NFD+ +D L   ET+      A  G HLPFVG++Y S   L D      
Sbjct: 359 IPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRV 418

Query: 410 VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAEVTLREL 466
             GPT ++L+   ++ L+ ++   + E  +   + E  E++          E+  T++ L
Sbjct: 419 TAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQESTQTVQAL 472

Query: 467 QEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAHVRQL-- 515
           Q +  +  LT       ++L  E+E +R   T++ +   QL EA A  ++L+   RQ+  
Sbjct: 473 QYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKA 532

Query: 516 -QERMELLQAE 525
            +++++ LQ E
Sbjct: 533 YEKQIKTLQQE 543


>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
           sapiens]
          Length = 1638

 Score =  521 bits (1342), Expect = e-148
 Identities = 279/551 (50%), Positives = 374/551 (67%), Gaps = 34/551 (6%)

Query: 1   MSAEVRLRRLQQLVLDPGF------LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWA 54
           MS EVRLR+L+Q +LD           +E LLD+L+ ++ E   S L ++K + ++L+WA
Sbjct: 1   MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60

Query: 55  EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 114
           +P   ++K++RL R+DFEILKVIGRGAF EVAVVK+K   +V+AMKI+NKW+MLKR E +
Sbjct: 61  KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120

Query: 115 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 174
           CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MARF
Sbjct: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180

Query: 175 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 234
           YLAE+V+AIDSVH+L YVHRDIKPDNIL+D  GHIRLADFGSCLKL  DGTV+S VAVGT
Sbjct: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240

Query: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
           PDY+SPEILQA+    G G YGPECDWW+LGV  YEM YG+TPFYA+S  ETYGKI+++K
Sbjct: 241 PDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298

Query: 295 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
           E    P     V E A+D I+RL+C  E RLG+ G  DF+ HPFF G+DWD +R+   P+
Sbjct: 299 ERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPY 358

Query: 355 TPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY-SCMALRDSE---- 409
            P+    TDT NFD+ +D L   ET+      A  G HLPFVG++Y S   L D      
Sbjct: 359 IPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRV 418

Query: 410 VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAEVTLREL 466
             GPT ++L+   ++ L+ ++   + E  +   + E  E++          E+  T++ L
Sbjct: 419 TAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQESTQTVQAL 472

Query: 467 QEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAHVRQL-- 515
           Q +  +  LT       ++L  E+E +R   T++ +   QL EA A  ++L+   RQ+  
Sbjct: 473 QYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKA 532

Query: 516 -QERMELLQAE 525
            +++++ LQ E
Sbjct: 533 YEKQIKTLQQE 543


>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
          Length = 1711

 Score =  515 bits (1326), Expect = e-146
 Identities = 278/561 (49%), Positives = 376/561 (67%), Gaps = 38/561 (6%)

Query: 1   MSAEVRLRRLQQLVLDPGF-----LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAE 55
           MSA+VRL++L+QL+LD  +     L +E LLD+L+ ++ E   S L +DKYVA+FL+WA+
Sbjct: 1   MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAK 60

Query: 56  PIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSC 115
           P    +KE++L R+DFEI+KVIGRGAF EVAVVKMK T ++YAMKI+NKW+MLKR E +C
Sbjct: 61  PFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120

Query: 116 FREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFY 175
           FREERDVLVNGD +WIT LH+AFQDEN+LYLVM+YYVGGDLLTLLSKF +++P +MARFY
Sbjct: 121 FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY 180

Query: 176 LAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTP 235
           + E+V+AIDS+H+L YVHRDIKPDN+LLD  GHIRLADFGSCLK+  DGTV+S VAVGTP
Sbjct: 181 IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 240

Query: 236 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 295
           DY+SPEILQA+    G G YGPECDWW+LGV  YEM YG+TPFYA+S  ETYGKI++++E
Sbjct: 241 DYISPEILQAM--EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEE 298

Query: 296 HLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFT 355
               P     V EEA+D IQRL+C  E RLG+ G  DF+ H FF GL+W+ +R+   P+ 
Sbjct: 299 RFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYI 358

Query: 356 PDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY---SCMA-------- 404
           PD    +DT NFD+ +D L   E L         G+HLPF+G+++   SC +        
Sbjct: 359 PDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSI 418

Query: 405 ------LRDSEVPGPT--PMELEAEQLLEPHVQAPSLEPSVSPQDETAEV----AVPAAV 452
                  +D +V       +++EA +     ++   LE S   Q+ T  V        A+
Sbjct: 419 MQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRAL 478

Query: 453 PAAEAEAEV-TLRELQEALEEEVLTRQSLSREME---AIRTDNQNFASQLREAEARNR-- 506
             +  + E+  L E  E L+ ++     L R++E   A+R + ++   +LR  E ++R  
Sbjct: 479 SNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVV 538

Query: 507 --DLEAHVRQLQERMELLQAE 525
             + E   +QL E  E L+++
Sbjct: 539 RQEKEELHKQLVEASERLKSQ 559



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 26/76 (34%), Positives = 43/76 (56%), Gaps = 4/76 (5%)

Query: 465 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQA 524
           ELQ ALE E+  +Q +  E+  ++  N    S+L+++EA+NR+L   +  L+++ME    
Sbjct: 878 ELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKME---- 933

Query: 525 EGATAVTGVPSPRATD 540
           E   A TG+  P   D
Sbjct: 934 EKFRADTGLKLPDFQD 949


>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
           sapiens]
          Length = 1551

 Score =  513 bits (1321), Expect = e-145
 Identities = 281/575 (48%), Positives = 361/575 (62%), Gaps = 55/575 (9%)

Query: 4   EVRLRRLQQLVLDP--GFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRL 61
           E RLR L+QL      G  GL+ LLDLLL +H EL +  L +++ VA FL WA P V ++
Sbjct: 2   ERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKV 61

Query: 62  KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERD 121
           KE+RLQRDDFEILKVIGRGAF EV VV+ + TGQ++AMK+++KW+MLKR E +CFREERD
Sbjct: 62  KELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERD 121

Query: 122 VLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 181
           VLV GD RW+T LH+AFQDE YLYLVM+YY GGDLLTLLS+F +R+P E+A+FYLAE+V+
Sbjct: 122 VLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVL 181

Query: 182 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 241
           AI S+H+LGYVHRD+KPDN+LLD  GHIRLADFGSCL+L  +G V S VAVGTPDY+SPE
Sbjct: 182 AIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPE 241

Query: 242 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 301
           ILQA+    G G YGP+CDWW+LGV AYE+ +G+TPFYA+S  ETYGKI+++++HL  P 
Sbjct: 242 ILQAM--EEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPP 299

Query: 302 VDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGA 361
               VP  A+D I++LLC  E RLGRGG  DFR HPFF G+DW+ L  S  P+ P+  G 
Sbjct: 300 DVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGP 359

Query: 362 TDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSC------------------M 403
            DT NFD+ +D L    TL     GA  G HLPFVG++Y+                   +
Sbjct: 360 MDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKL 419

Query: 404 ALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSP-QDETAEV-----------AVPAA 451
              + E    +    EA      H +   L   V   +D   E+             PA 
Sbjct: 420 QCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAG 479

Query: 452 VPAAEAEAEVTL----RELQE----------------ALEEEVLTRQSLSREME-AIRTD 490
            P  +++    L    REL E                  +EE+L R   ++E E A  + 
Sbjct: 480 SPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQ 539

Query: 491 NQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 525
            +  +SQL EA A  R+LEA V  L  ++  LQ +
Sbjct: 540 TRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQ 574



 Score = 33.5 bits (75), Expect = 0.60
 Identities = 16/55 (29%), Positives = 30/55 (54%)

Query: 465 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERM 519
           ELQ ALE E+  +Q L   +  ++        +L+EAE +++ L+  +  L+E +
Sbjct: 744 ELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL 798


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
           [Homo sapiens]
          Length = 1354

 Score =  366 bits (940), Expect = e-101
 Identities = 205/565 (36%), Positives = 323/565 (57%), Gaps = 44/565 (7%)

Query: 2   SAEVRLRRLQQLVLDP-GFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
           S E R  ++  L+ DP   +  + LLD L  +  +L    L ++K + +FL   +  + +
Sbjct: 6   SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINK 65

Query: 61  LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
           ++++R++ +D+E++KVIGRGAF EV +V+ K T +VYAMK+++K++M+KR + + F EER
Sbjct: 66  IRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEER 125

Query: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
           D++   +  W+ QL +AFQD+ YLY+VMEY  GGDL+ L+S +   +P + ARFY AE+V
Sbjct: 126 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVV 183

Query: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
           +A+D++H +G++HRD+KPDN+LLD+ GH++LADFG+C+K+  +G VR   AVGTPDY+SP
Sbjct: 184 LALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISP 243

Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
           E+L++ G   G G YG ECDWW++GVF YEM  G TPFYADS   TY KI+++K  L+ P
Sbjct: 244 EVLKSQG---GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP 300

Query: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPDF 358
             D  + +EA++ I   L   E RLGR G  + + H FF      W+ LRD+V P  PD 
Sbjct: 301 -DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDL 359

Query: 359 EGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYS-YSCMALRDSEVPGPTPME 417
               DT NFD +E+     ET    +  A +G  LPFVG++ YS      S  P      
Sbjct: 360 SSDIDTSNFDDLEEDKGEEETFPIPK--AFVGNQLPFVGFTYYSNRRYLSSANPNDNRTS 417

Query: 418 LEAEQLLEPHVQAP------------SLEPSVSPQDETAEVAVPAAVPAAEAEA------ 459
             A++ L+  +Q               L+  +  +  T+ + +   +   + E       
Sbjct: 418 SNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNL 477

Query: 460 --------------EVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARN 505
                         +  + E Q   E+E   R+++  E+  ++   ++     + ++  N
Sbjct: 478 ESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLAN 537

Query: 506 RDLEAHVRQLQERMELLQAEGATAV 530
             L    +QL+E  +LL+ E  TAV
Sbjct: 538 EKLSQLQKQLEEANDLLRTESDTAV 562


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
           [Homo sapiens]
          Length = 1388

 Score =  365 bits (937), Expect = e-101
 Identities = 202/525 (38%), Positives = 310/525 (59%), Gaps = 40/525 (7%)

Query: 6   RLRRLQQLVLDPGF-LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEV 64
           R R+L+ L+ DP   + +E LLD L  +  +L    L ++K + +FL   E IV +++ +
Sbjct: 26  RQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGL 85

Query: 65  RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 124
           +++ +D++++KVIGRGAF EV +V+ K + +VYAMK+++K++M+KR + + F EERD++ 
Sbjct: 86  QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 145

Query: 125 NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 184
             +  W+ QL +AFQD+ YLY+VMEY  GGDL+ L+S +   +P + A+FY AE+V+A+D
Sbjct: 146 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALD 203

Query: 185 SVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQ 244
           ++H +G +HRD+KPDN+LLD+ GH++LADFG+C+K+   G V    AVGTPDY+SPE+L+
Sbjct: 204 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 263

Query: 245 AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDE 304
           + G   G G YG ECDWW++GVF YEM  G TPFYADS   TY KI+ +K  L  P  D 
Sbjct: 264 SQG---GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFP-EDA 319

Query: 305 GVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPDFEGAT 362
            + + A++ I   L   E RLGR G  + R HPFF      WD +R++  P  P+     
Sbjct: 320 EISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDI 379

Query: 363 DTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQ 422
           D+ NFD +ED    +ET    +  A +G  LPF+G++Y                    E 
Sbjct: 380 DSSNFDDIEDDKGDVETFPIPK--AFVGNQLPFIGFTY------------------YREN 419

Query: 423 LLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSR 482
           LL     +PS   + S Q    E            E +  L  L+E L  E+  ++ L +
Sbjct: 420 LLLS--DSPSCRETDSIQSRKNE---------ESQEIQKKLYTLEEHLSNEMQAKEELEQ 468

Query: 483 EMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGA 527
           + +++ T  +  A +L E     + +E+ +RQL+    LLQ + A
Sbjct: 469 KCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA 513


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score =  335 bits (858), Expect = 1e-91
 Identities = 193/513 (37%), Positives = 294/513 (57%), Gaps = 33/513 (6%)

Query: 20  LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGR 79
           L  E +LD L  + +E     L + K+V++F++     +  L+E++    DFE+  ++G 
Sbjct: 46  LSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGC 105

Query: 80  GAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQ 139
           G F+EV VV+ K TG +YAMK+M K  +L + +VS F EER++L      WI QL +AFQ
Sbjct: 106 GHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQ 165

Query: 140 DENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPD 199
           D+N+LYLVMEY  GGDLL+LL+++ +++   + +FYLAE+++A+ SVH +GYVHRDIKP+
Sbjct: 166 DKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPE 225

Query: 200 NILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPEC 259
           NIL+DR GHI+L DFGS  K+ ++  V + + +GTPDY++PE+L  V  G G G+YG +C
Sbjct: 226 NILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVL-TVMNGDGKGTYGLDC 284

Query: 260 DWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLC 319
           DWW++GV AYEM YG++PF   ++A T+  I++++  L  P  D  V  +  D IQ LLC
Sbjct: 285 DWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFP-DDPKVSSDFLDLIQSLLC 343

Query: 320 PPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMET 379
             + RL   G      HPFF  +DW+ +R+S PPF P  +   DT NFD  E       +
Sbjct: 344 GQKERLKFEG---LCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSS 400

Query: 380 LSDIREGAPLGVHLPFVGYSYS----CMALRDSEVPG---PTPMELEAEQLLEPHVQAPS 432
              +      G  LPFVG+SYS     +   +S V G   P       ++LL   +++  
Sbjct: 401 PCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLL---IKSKE 457

Query: 433 LEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQ 492
           L+ S     +  +         +E EA ++ +E++    E   T++SL           Q
Sbjct: 458 LQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASE---TQRSLL---------EQ 505

Query: 493 NFASQLREAEARNRDLEAHVRQLQERMELLQAE 525
           + A+ + E  +  R LE      Q RME+ Q +
Sbjct: 506 DLATYITECSSLKRSLE------QARMEVSQED 532



 Score = 32.7 bits (73), Expect = 1.0
 Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 458 EAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQE 517
           E E  LRE+    EE+ L    L R++  ++   Q   SQL   +A    LE+ +RQ + 
Sbjct: 853 ELETRLREVSLEHEEQKL---ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT 909

Query: 518 RMELLQAEGATAVTGVPSPR 537
            +E   AE    +  + + R
Sbjct: 910 ELEETTAEAEEEIQALTAHR 929



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 5/82 (6%)

Query: 442 ETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIR---TDNQNFASQL 498
           E  E AV A+  A E    +  R+ +E  E E+   Q+     E IR    + +    + 
Sbjct: 643 EKLEKAVKASTEATELLQNI--RQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKH 700

Query: 499 REAEARNRDLEAHVRQLQERME 520
           REA+   + LE H++Q ++  E
Sbjct: 701 REAQVSAQHLEVHLKQKEQHYE 722



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 28/97 (28%), Positives = 41/97 (42%), Gaps = 5/97 (5%)

Query: 421 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 480
           EQ LE   Q   L+ S+  ++         A+ AA A  E  LR+ +  LEE     +  
Sbjct: 867 EQKLELKRQLTELQLSLQERESQL-----TALQAARAALESQLRQAKTELEETTAEAEEE 921

Query: 481 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQE 517
            + + A R + Q     LR +     DLE  + QL E
Sbjct: 922 IQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 958


>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
          Length = 464

 Score =  275 bits (703), Expect = 9e-74
 Identities = 141/344 (40%), Positives = 206/344 (59%), Gaps = 43/344 (12%)

Query: 59  VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118
           +RLK  RL  DDFE LKVIGRGAF EV +V+ K TG +YAMKI+ K DML++ +V+  R 
Sbjct: 78  LRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRA 137

Query: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178
           ERD+LV  D  W+ ++ ++FQD+  LYL+ME+  GGD++TLL K  + +  E  +FY++E
Sbjct: 138 ERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISE 196

Query: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222
            V+AID++H+LG++HRDIKPDN+LLD  GH++L+DFG C  L+                +
Sbjct: 197 TVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPS 256

Query: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264
           D + +++                    VGTPDY++PE+    G       Y   CDWW+L
Sbjct: 257 DFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 309

Query: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324
           GV  YEM  G  PF +++  ETY K++++KE L  P  +  + E+A+D I R     E R
Sbjct: 310 GVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFP-PEVPISEKAKDLILRFCIDSENR 368

Query: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368
           +G  G  + + HPFF G+DW+ +R+       + +   DT NFD
Sbjct: 369 IGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFD 412


>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
          Length = 465

 Score =  274 bits (701), Expect = 2e-73
 Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)

Query: 59  VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118
           +RLK  RL  +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V   R 
Sbjct: 77  LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136

Query: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178
           ERD+LV  D  W+ ++ ++FQD+  LYL+ME+  GGD++TLL K  + +  E  +FY+AE
Sbjct: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195

Query: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222
            V+AIDS+H+LG++HRDIKPDN+LLD  GH++L+DFG C  L+                +
Sbjct: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255

Query: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264
           D T +++                    VGTPDY++PE+    G       Y   CDWW+L
Sbjct: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308

Query: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324
           GV  YEM  G  PF +++  ETY K++++KE L+ P  +  + E+A+D I R  C  E R
Sbjct: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367

Query: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368
           +G  G  + +++ FF G+DW+ +R+     + + +   DT NFD
Sbjct: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411


>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
           sapiens]
          Length = 1309

 Score =  217 bits (552), Expect = 3e-56
 Identities = 120/314 (38%), Positives = 174/314 (55%), Gaps = 25/314 (7%)

Query: 70  DFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRR 129
           DFE +K+I  GA+  V +V+ + T Q +A+K +NK +++ R ++     ERD+L   +  
Sbjct: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425

Query: 130 WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRL 189
           ++  +  +F+   +L +VMEY  GGD  TLL   G  +P +MAR Y AE V+A++ +H  
Sbjct: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP-LPVDMARLYFAETVLALEYLHNY 484

Query: 190 GYVHRDIKPDNILLDRCGHIRLADFG-SCLKLRADGT----------VRSLV---AVGTP 235
           G VHRD+KPDN+L+   GHI+L DFG S + L +  T           R  +     GTP
Sbjct: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTP 544

Query: 236 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 295
           +Y++PE++   G       YG   DWWA+GV  YE   G  PF+ D+  E +G++V   +
Sbjct: 545 EYIAPEVIFRQG-------YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVV--SD 595

Query: 296 HLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
            +  P  DE +P +A+D I RLL   P  RLG GG  + + HPFF  LDW GL      F
Sbjct: 596 EIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEF 655

Query: 355 TPDFEGATDTCNFD 368
            P  E   DT  FD
Sbjct: 656 VPQLEAEDDTSYFD 669


>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
           sapiens]
          Length = 1798

 Score =  215 bits (548), Expect = 9e-56
 Identities = 129/380 (33%), Positives = 192/380 (50%), Gaps = 36/380 (9%)

Query: 69  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
           +DFE +K+I  GA+  V +V+ K T Q +AMK +NK +++ R ++     ERD+L   + 
Sbjct: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569

Query: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
            ++  +  +F  + +L +VMEY  GGD  TLL   G  +P +M R Y AE V+A++ +H 
Sbjct: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIG-ALPVDMVRLYFAETVLALEYLHN 628

Query: 189 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 234
            G VHRD+KPDN+L+   GHI+L DFG           +  +   +   R  +     GT
Sbjct: 629 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGT 688

Query: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
           P+Y++PE++   G       YG   DWWA+G+  YE   G  PF+ D+  E +G+++   
Sbjct: 689 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 739

Query: 295 EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
           + +  P  DE +P +A+D   +LL   P  RLG G A + + HPFF GLDW GL      
Sbjct: 740 DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAE 799

Query: 354 FTPDFEGATDTCNFDLVEDGLTAM--ETLSDIREGAPLGVH-----LPFVGYSYSCM--- 403
           F P  E   DT  FD   +    M  E   ++ E   L +       P     YS M   
Sbjct: 800 FIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERL 859

Query: 404 -ALRDSEVPGPTPMELEAEQ 422
             L +   P PT   L  E+
Sbjct: 860 SLLEERRTPPPTKRSLSEEK 879


>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
           sapiens]
          Length = 1570

 Score =  214 bits (546), Expect = 1e-55
 Identities = 157/510 (30%), Positives = 231/510 (45%), Gaps = 48/510 (9%)

Query: 69  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
           +DF+ +K+I  GA+  V +V+ + T Q +AMK +NK +++ R ++     ERD+L   + 
Sbjct: 372 NDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 431

Query: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
            ++  +  +F+   +L +VMEY  GGD  TLL   G  +P EMAR Y AE V+A++ +H 
Sbjct: 432 PFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGA-LPVEMARMYFAETVLALEYLHN 490

Query: 189 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 234
            G VHRD+KPDN+L+   GHI+L DFG           +  +   +   R  +     GT
Sbjct: 491 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGT 550

Query: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
           P+Y++PE++   G       YG   DWWA+G+  YE   G  PF+ D+  E +G+++   
Sbjct: 551 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 601

Query: 295 EHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
           + +  P  DE +P EA+  I  LL   P  RLG GGA + + H FF  LDW GL      
Sbjct: 602 DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAE 661

Query: 354 FTPDFEGATDTCNFDLVEDGLTAMETL--SDIREGAPLGVH-----LPFVGYSYSCMALR 406
           F P  E   DT  FD   D    + +    D  E  P+ +       P     YS M   
Sbjct: 662 FIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQL 721

Query: 407 DSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLREL 466
               P  TP+        EP  + P  E  V+ + E                 E+     
Sbjct: 722 SQHEP-KTPVAAAGSSKREPSTKGP--EEKVAGKREGLGGLTLREKTWRGGSPEIKRFSA 778

Query: 467 QEA--LEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNR-----------DLEAHVR 513
            EA  LE E        R   A+   ++  A Q  E EAR R            L+A   
Sbjct: 779 SEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAP 838

Query: 514 QLQERMELLQAEGATAVTGVPSPRATDPPS 543
           + + + E   + G +  T  P P    PPS
Sbjct: 839 KEETQGEGTSSAGDSEATDRPRPGDLCPPS 868


>gi|148727255 microtubule associated serine/threonine kinase family
           member 4 isoform a [Homo sapiens]
          Length = 2434

 Score =  211 bits (538), Expect = 1e-54
 Identities = 116/328 (35%), Positives = 177/328 (53%), Gaps = 25/328 (7%)

Query: 67  QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNG 126
           +  DFE +K+I  GA+  V  V+ K++ Q +AMK +NK +++ R ++     ERD+L   
Sbjct: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436

Query: 127 DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSV 186
           +  ++  ++ +F+   +L +VMEY  GGD  TL+   G  +P +MAR Y AE V+A++ +
Sbjct: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGP-LPVDMARMYFAETVLALEYL 495

Query: 187 HRLGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AV 232
           H  G VHRD+KPDN+L+   GHI+L DFG           +  +   +   R  +     
Sbjct: 496 HNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVC 555

Query: 233 GTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVH 292
           GTP+Y++PE++   G       YG   DWWA+G+  YE   G  PF+ D+  E +G+++ 
Sbjct: 556 GTPEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI- 607

Query: 293 YKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSV 351
             + ++ P  DE  P +A+D I  LL   P  RLG GGA + + H FF  LDW+ L    
Sbjct: 608 -SDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQK 666

Query: 352 PPFTPDFEGATDTCNFDLVEDGLTAMET 379
             F P  E   DT  FD   +    MET
Sbjct: 667 AEFIPQLESEDDTSYFDTRSEKYHHMET 694


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  200 bits (508), Expect = 4e-51
 Identities = 125/339 (36%), Positives = 188/339 (55%), Gaps = 28/339 (8%)

Query: 65  RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVL- 123
           RL  D+FE ++V+G+G+F +V + ++K+TG +YA+K++ K  +L+  +V C   E+ +L 
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408

Query: 124 VNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 183
           +  +  ++TQL   FQ  + L+ VME+  GGDL+  + K   R     ARFY AEI+ A+
Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQK-SRRFDEARARFYAAEIISAL 467

Query: 184 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 243
             +H  G ++RD+K DN+LLD  GH +LADFG C +   +G V +    GTPDY++PEIL
Sbjct: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNG-VTTATFCGTPDYIAPEIL 526

Query: 244 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD 303
           Q +        YGP  DWWA+GV  YEM  G  PF A++  + +  I++  + +  P   
Sbjct: 527 QEM-------LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN--DEVVYP--- 574

Query: 304 EGVPEEARDFIQRLLCP-PETRLG---RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPD 357
             + E+A   ++  +   P  RLG   +GG      HPFF  +DW  L  R   PPF P 
Sbjct: 575 TWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPR 634

Query: 358 FEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFV 396
            +   D  NFD   D +     L+ I EG     HLP +
Sbjct: 635 IKSREDVSNFD--PDFIKEEPVLTPIDEG-----HLPMI 666


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  197 bits (502), Expect = 2e-50
 Identities = 130/360 (36%), Positives = 190/360 (52%), Gaps = 26/360 (7%)

Query: 56  PIVVRLKEVRLQRD--DFEILKVIGRGAFSEVAVVKMK---QTGQVYAMKIMNKWDMLKR 110
           PI   +KE   + D   FE+LKV+G+G+F +V +V+ K     GQ+YAMK++ K  +  R
Sbjct: 56  PITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVR 115

Query: 111 GEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE 170
             V   + ERD+LV  +  +I +LH+AFQ E  LYL++++  GGD+ T LSK       E
Sbjct: 116 DRVRT-KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEE 173

Query: 171 MARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLV 230
             +FYLAE+ +A+D +H+LG V+RD+KP+NILLD  GHI+L DFG   K   D   ++  
Sbjct: 174 DVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG-LSKESVDQEKKAYS 232

Query: 231 AVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI 290
             GT +Y++PE++   G       +    DWW+ GV  +EM  G  PF      ET   I
Sbjct: 233 FCGTVEYMAPEVVNRRG-------HSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMI 285

Query: 291 VHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGL-- 347
           +  K  L +P   + +  EA+  ++ L    P  RLG  G  + + H FF  +DWD L  
Sbjct: 286 L--KAKLGMP---QFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYK 340

Query: 348 RDSVPPFTPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRD 407
           R+  PPF P      DT  FD      TA          A    H  F G+S+   ++ +
Sbjct: 341 REVQPPFKPASGKPDDTFCFD---PEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAE 397



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 73/216 (33%), Positives = 106/216 (49%), Gaps = 27/216 (12%)

Query: 71  FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN-GDRR 129
           +E+ + IG G++S         T   +A+KI++K    KR       EE ++L+  G   
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDK---SKRDP----SEEIEILMRYGQHP 478

Query: 130 WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSK---FGERIPAEMARFYLAEIVMAIDSV 186
            I  L   F D  Y+YLV +   GG+LL  + K   F ER  +++    L  I   +D +
Sbjct: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDI----LYVISKTVDYL 534

Query: 187 HRLGYVHRDIKPDNIL-LDRCGH---IRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEI 242
           H  G VHRD+KP NIL +D       IR+ DFG   +LR +  +  L    T ++++PE+
Sbjct: 535 HCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLL-LTPCYTANFVAPEV 593

Query: 243 LQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 278
           L   G       Y   CD W+LGV  Y M  G TPF
Sbjct: 594 LMQQG-------YDAACDIWSLGVLFYTMLAGYTPF 622


>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 1 [Homo sapiens]
          Length = 351

 Score =  197 bits (500), Expect = 3e-50
 Identities = 125/352 (35%), Positives = 188/352 (53%), Gaps = 38/352 (10%)

Query: 31  GVHQELGASELAQDKYVADFLQ-WAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVK 89
           G  QE     LA+ K   DFL+ W  P      +     D FE +K +G G+F  V +VK
Sbjct: 10  GSEQESVKEFLAKAK--EDFLKKWESPA-----QNTAHLDQFERIKTLGTGSFGRVMLVK 62

Query: 90  MKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME 149
            K+TG  YAMKI++K  ++K  ++     E+ +L   +  ++ +L F+F+D + LY+VME
Sbjct: 63  HKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVME 122

Query: 150 YYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHI 209
           Y  GG++ + L + G R     ARFY A+IV+  + +H L  ++RD+KP+N+L+D+ G+I
Sbjct: 123 YVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI 181

Query: 210 RLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAY 269
           ++ DFG   +++     R+    GTP+YL+PEI+ + G       Y    DWWALGV  Y
Sbjct: 182 QVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG-------YNKAVDWWALGVLIY 230

Query: 270 EMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDEGVPEEARDFIQRLLCPPET-R 324
           EM  G  PF+AD   + Y KI    V +  H S          + +D ++ LL    T R
Sbjct: 231 EMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS---------SDLKDLLRNLLQVDLTKR 281

Query: 325 LG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGATDTCNFDLVED 372
            G  + G  D + H +F   DW  +  R    PF P F+G  DT NFD  E+
Sbjct: 282 FGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333


>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
           sapiens]
          Length = 351

 Score =  197 bits (500), Expect = 3e-50
 Identities = 118/330 (35%), Positives = 178/330 (53%), Gaps = 28/330 (8%)

Query: 49  DFL-QWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDM 107
           DFL +W  P      +     D FE L+ +G G+F  V +V+ ++TG  YAMKI+NK  +
Sbjct: 26  DFLYRWGNPA-----QNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKV 80

Query: 108 LKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERI 167
           +K  +V     E+ +L   D  ++ +L F+F+D +YLYLVMEY  GG++ + L + G R 
Sbjct: 81  VKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVG-RF 139

Query: 168 PAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVR 227
               A FY A++V+A+  +H L  +HRD+KP+N+L+D+ G++++ DFG   +++     R
Sbjct: 140 SEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG----R 195

Query: 228 SLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETY 287
           +    GTP+YL+PEI+ + G       Y    DWWALGV  YEM  G  PFYAD   + Y
Sbjct: 196 TWTLCGTPEYLAPEIILSKG-------YNKAVDWWALGVLIYEMAVGFPPFYADQPIQIY 248

Query: 288 GKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDW 344
            KIV  +      L       + +  ++ LL    T R G  R G GD + H +F    W
Sbjct: 249 EKIVSGRVRFPSKL-----SSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSW 303

Query: 345 DGLRDS--VPPFTPDFEGATDTCNFDLVED 372
             + +     PF P + G  D  NFD  E+
Sbjct: 304 IAIYEKKVEAPFIPKYTGPGDASNFDDYEE 333


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  196 bits (497), Expect = 7e-50
 Identities = 116/312 (37%), Positives = 176/312 (56%), Gaps = 22/312 (7%)

Query: 65  RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 124
           RL  D+F  +KV+G+G+F +V + ++K   +VYA+K++ K  +L+  +V C   E+ +L 
Sbjct: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461

Query: 125 NGDRR-WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 183
              +  ++TQL+  FQ ++ L+ VMEY  GGDL+  + +   +     +RFY AE+  A+
Sbjct: 462 LARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQR-SRKFDEPRSRFYAAEVTSAL 520

Query: 184 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 243
             +H+ G ++RD+K DNILLD  GH +LADFG C +   +G V +    GTPDY++PEIL
Sbjct: 521 MFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNG-VTTTTFCGTPDYIAPEIL 579

Query: 244 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD 303
           Q +        YGP  DWWALGV  YEM  GQ PF AD+  + +  I+H  + +  P+  
Sbjct: 580 QEL-------EYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILH--DDVLYPV-- 628

Query: 304 EGVPEEARDFIQRLLCP-PETRLG----RGGAGDFRTHPFFFGLDWDGLRDS--VPPFTP 356
             + +EA   ++  +   P  RLG    + G    + HPFF  +DW  L      PPF P
Sbjct: 629 -WLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKP 687

Query: 357 DFEGATDTCNFD 368
             +   D  NFD
Sbjct: 688 RIKTKRDVNNFD 699


>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 2 [Homo sapiens]
          Length = 343

 Score =  196 bits (497), Expect = 7e-50
 Identities = 114/313 (36%), Positives = 174/313 (55%), Gaps = 30/313 (9%)

Query: 69  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
           D FE +K +G G+F  V +VK K+TG  YAMKI++K  ++K  ++     E+ +L   + 
Sbjct: 34  DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 93

Query: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
            ++ +L F+F+D + LY+VMEY  GG++ + L + G R     ARFY A+IV+  + +H 
Sbjct: 94  PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHS 152

Query: 189 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 248
           L  ++RD+KP+N+L+D+ G+I++ DFG   +++     R+    GTP+YL+PEI+ + G 
Sbjct: 153 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG- 207

Query: 249 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDE 304
                 Y    DWWALGV  YEM  G  PF+AD   + Y KI    V +  H S      
Sbjct: 208 ------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS------ 255

Query: 305 GVPEEARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFE 359
               + +D ++ LL    T R G  + G  D + H +F   DW  +  R    PF P F+
Sbjct: 256 ---SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFK 312

Query: 360 GATDTCNFDLVED 372
           G  DT NFD  E+
Sbjct: 313 GPGDTSNFDDYEE 325


>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
           isoform 1 [Homo sapiens]
          Length = 398

 Score =  196 bits (497), Expect = 7e-50
 Identities = 121/342 (35%), Positives = 185/342 (54%), Gaps = 34/342 (9%)

Query: 44  DKYVADFLQWAEPIVVRLKEVRLQR----DDFEILKVIGRGAFSEVAVVKMKQTGQVYAM 99
           D+ + +FL  A+   ++  E   Q     +DFE  K +G G+F  V +VK K T Q YAM
Sbjct: 60  DRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAM 119

Query: 100 KIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTL 159
           KI++K  ++K  ++     E+ +L   +  ++ +L +AF+D + LY+VMEY  GG++ + 
Sbjct: 120 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSH 179

Query: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
           L + G R     ARFY A+IV+  + +H L  ++RD+KP+N+L+D  G+I++ DFG   +
Sbjct: 180 LRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR 238

Query: 220 LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFY 279
           ++     R+    GTP+YL+PEI+ + G       Y    DWWALGV  YEM  G  PF+
Sbjct: 239 VKG----RTWTLCGTPEYLAPEIILSKG-------YNKAVDWWALGVLIYEMAAGYPPFF 287

Query: 280 ADSTAETYGKI----VHYKEHLSLPLVDEGVPEEARDFIQRLLCPPET-RLG--RGGAGD 332
           AD   + Y KI    V +  H S          + +D ++ LL    T R G  + G  D
Sbjct: 288 ADQPIQIYEKIVSGKVRFPSHFS---------SDLKDLLRNLLQVDLTKRFGNLKNGVSD 338

Query: 333 FRTHPFFFGLDWDGL--RDSVPPFTPDFEGATDTCNFDLVED 372
            +TH +F   DW  +  R    PF P F G+ DT NFD  E+
Sbjct: 339 IKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEE 380


>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
           isoform 2 [Homo sapiens]
          Length = 351

 Score =  195 bits (496), Expect = 9e-50
 Identities = 115/313 (36%), Positives = 173/313 (55%), Gaps = 30/313 (9%)

Query: 69  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
           +DFE  K +G G+F  V +VK K T Q YAMKI++K  ++K  ++     E+ +L   + 
Sbjct: 42  EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101

Query: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
            ++ +L +AF+D + LY+VMEY  GG++ + L + G R     ARFY A+IV+  + +H 
Sbjct: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHS 160

Query: 189 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 248
           L  ++RD+KP+N+L+D  G+I++ DFG   +++     R+    GTP+YL+PEI+ + G 
Sbjct: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG- 215

Query: 249 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDE 304
                 Y    DWWALGV  YEM  G  PF+AD   + Y KI    V +  H S      
Sbjct: 216 ------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS------ 263

Query: 305 GVPEEARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFE 359
               + +D ++ LL    T R G  + G  D +TH +F   DW  +  R    PF P F 
Sbjct: 264 ---SDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFR 320

Query: 360 GATDTCNFDLVED 372
           G+ DT NFD  E+
Sbjct: 321 GSGDTSNFDDYEE 333


>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform b [Homo sapiens]
          Length = 741

 Score =  189 bits (479), Expect = 9e-48
 Identities = 117/306 (38%), Positives = 170/306 (55%), Gaps = 23/306 (7%)

Query: 71  FEILKVIGRGAFSEVAVV---KMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 127
           FE+LKV+G+G++ +V +V   K    GQ+YAMK++ K  +  R  V   + ERD+L   +
Sbjct: 67  FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILAEVN 125

Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVH 187
             +I +LH+AFQ E  LYL++++  GGDL T LSK       E  +FYLAE+ +A+D +H
Sbjct: 126 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 184

Query: 188 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 247
            LG ++RD+KP+NILLD  GHI++ DFG   K   D   R+    GT +Y++PE++   G
Sbjct: 185 SLGIIYRDLKPENILLDEEGHIKITDFG-LSKEAIDHDKRAYSFCGTIEYMAPEVVNRRG 243

Query: 248 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVP 307
                  +    DWW+ GV  +EM  G  PF      ET   I+  K  L +P    G  
Sbjct: 244 -------HTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL--KAKLGMPQFLSG-- 292

Query: 308 EEARDFIQRLL-CPPETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGAT 362
            EA+  ++ L    P  RLG G  G  + + HPFF  +DW+ L  ++  PPF P      
Sbjct: 293 -EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPE 351

Query: 363 DTCNFD 368
           DT +FD
Sbjct: 352 DTFHFD 357



 Score =  100 bits (248), Expect = 5e-21
 Identities = 99/302 (32%), Positives = 144/302 (47%), Gaps = 34/302 (11%)

Query: 38  ASELAQDKYVADFLQW-AEPIVVRLKEVRLQ-RDDFEILKVIGRGAFSEVAVVKMKQTGQ 95
           AS L Q+    D  +    PIV +L    +   D +EI + IG G++S       K T  
Sbjct: 388 ASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDT 447

Query: 96  VYAMKIMNKWDMLKRGEVSCFREERDVLVN-GDRRWITQLHFAFQDENYLYLVMEYYVGG 154
            YA+KI++K    KR       EE ++L+  G    I  L   + D  ++YLVME   GG
Sbjct: 448 EYAVKIIDK---SKRDP----SEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG 500

Query: 155 DLLTLLSK---FGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILL-DRCG--- 207
           +LL  + +   F ER  +++    L  I   +D +H  G VHRD+KP NIL  D  G   
Sbjct: 501 ELLDRILRQRYFSEREASDV----LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPE 556

Query: 208 HIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVF 267
            IR+ DFG   +LRA G    +    T ++++PE+L+  G       Y   CD W+LG+ 
Sbjct: 557 SIRVCDFGFAKQLRA-GNGLLMTPCYTANFVAPEVLKRQG-------YDAACDIWSLGIL 608

Query: 268 AYEMFYGQTPFY---ADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPET 323
            Y M  G TPF     D+  E   +I   K  LS    D  + + A+D + ++L   P  
Sbjct: 609 LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWD-SISDAAKDVVSKMLHVDPHQ 667

Query: 324 RL 325
           RL
Sbjct: 668 RL 669


>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
           isoform a [Homo sapiens]
          Length = 733

 Score =  189 bits (479), Expect = 9e-48
 Identities = 117/306 (38%), Positives = 170/306 (55%), Gaps = 23/306 (7%)

Query: 71  FEILKVIGRGAFSEVAVV---KMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 127
           FE+LKV+G+G++ +V +V   K    GQ+YAMK++ K  +  R  V   + ERD+L   +
Sbjct: 59  FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILAEVN 117

Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVH 187
             +I +LH+AFQ E  LYL++++  GGDL T LSK       E  +FYLAE+ +A+D +H
Sbjct: 118 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 176

Query: 188 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 247
            LG ++RD+KP+NILLD  GHI++ DFG   K   D   R+    GT +Y++PE++   G
Sbjct: 177 SLGIIYRDLKPENILLDEEGHIKITDFG-LSKEAIDHDKRAYSFCGTIEYMAPEVVNRRG 235

Query: 248 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVP 307
                  +    DWW+ GV  +EM  G  PF      ET   I+  K  L +P    G  
Sbjct: 236 -------HTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL--KAKLGMPQFLSG-- 284

Query: 308 EEARDFIQRLL-CPPETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGAT 362
            EA+  ++ L    P  RLG G  G  + + HPFF  +DW+ L  ++  PPF P      
Sbjct: 285 -EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPE 343

Query: 363 DTCNFD 368
           DT +FD
Sbjct: 344 DTFHFD 349



 Score =  100 bits (248), Expect = 5e-21
 Identities = 99/302 (32%), Positives = 144/302 (47%), Gaps = 34/302 (11%)

Query: 38  ASELAQDKYVADFLQW-AEPIVVRLKEVRLQ-RDDFEILKVIGRGAFSEVAVVKMKQTGQ 95
           AS L Q+    D  +    PIV +L    +   D +EI + IG G++S       K T  
Sbjct: 380 ASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDT 439

Query: 96  VYAMKIMNKWDMLKRGEVSCFREERDVLVN-GDRRWITQLHFAFQDENYLYLVMEYYVGG 154
            YA+KI++K    KR       EE ++L+  G    I  L   + D  ++YLVME   GG
Sbjct: 440 EYAVKIIDK---SKRDP----SEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG 492

Query: 155 DLLTLLSK---FGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILL-DRCG--- 207
           +LL  + +   F ER  +++    L  I   +D +H  G VHRD+KP NIL  D  G   
Sbjct: 493 ELLDRILRQRYFSEREASDV----LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPE 548

Query: 208 HIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVF 267
            IR+ DFG   +LRA G    +    T ++++PE+L+  G       Y   CD W+LG+ 
Sbjct: 549 SIRVCDFGFAKQLRA-GNGLLMTPCYTANFVAPEVLKRQG-------YDAACDIWSLGIL 600

Query: 268 AYEMFYGQTPFY---ADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPET 323
            Y M  G TPF     D+  E   +I   K  LS    D  + + A+D + ++L   P  
Sbjct: 601 LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWD-SISDAAKDVVSKMLHVDPHQ 659

Query: 324 RL 325
           RL
Sbjct: 660 RL 661


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  188 bits (477), Expect = 1e-47
 Identities = 110/310 (35%), Positives = 169/310 (54%), Gaps = 20/310 (6%)

Query: 63  EVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDV 122
           +++L+ +DF + K++G+G+F +V + + K+T Q +A+K + K  +L   +V C   E+ V
Sbjct: 372 QIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRV 431

Query: 123 L-VNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 181
           L +  +  ++T +   FQ +  L+ VMEY  GGDL+  +     +     A FY AEI++
Sbjct: 432 LSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSC-HKFDLSRATFYAAEIIL 490

Query: 182 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 241
            +  +H  G V+RD+K DNILLD+ GHI++ADFG C K    G  ++    GTPDY++PE
Sbjct: 491 GLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMC-KENMLGDAKTNTFCGTPDYIAPE 549

Query: 242 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 301
           IL           Y    DWW+ GV  YEM  GQ+PF+     E +  I      +  P 
Sbjct: 550 ILLG-------QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI-----RMDNPF 597

Query: 302 VDEGVPEEARDFIQRLLC-PPETRLGRGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDF 358
               + +EA+D + +L    PE RL  G  GD R HP F  ++W+ L  ++  PPF P  
Sbjct: 598 YPRWLEKEAKDLLVKLFVREPEKRL--GVRGDIRQHPLFREINWEELERKEIDPPFRPKV 655

Query: 359 EGATDTCNFD 368
           +   D  NFD
Sbjct: 656 KSPFDCSNFD 665


>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform b [Homo sapiens]
          Length = 744

 Score =  187 bits (475), Expect = 2e-47
 Identities = 122/349 (34%), Positives = 185/349 (53%), Gaps = 30/349 (8%)

Query: 71  FEILKVIGRGAFSEVAVVKM---KQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 127
           FE+LKV+G+G+F +V +V+      +G +YAMK++ K  +  R  V   + ERD+L + +
Sbjct: 71  FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRT-KMERDILADVN 129

Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVH 187
             ++ +LH+AFQ E  LYL++++  GGDL T LSK       E  +FYLAE+ + +D +H
Sbjct: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALGLDHLH 188

Query: 188 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 247
            LG ++RD+KP+NILLD  GHI+L DFG   K   D   ++    GT +Y++PE++   G
Sbjct: 189 SLGIIYRDLKPENILLDEEGHIKLTDFG-LSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 247

Query: 248 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVP 307
                  +    DWW+ GV  +EM  G  PF      ET   I+  K  L +P   + + 
Sbjct: 248 -------HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL--KAKLGMP---QFLS 295

Query: 308 EEARDFIQRLL-CPPETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGAT 362
            EA+  ++ L    P  RLG G  GA + + H F+  +DW+ L  R+  PPF P      
Sbjct: 296 TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPD 355

Query: 363 DTCNFDLVEDGLTAMETLSDIREGAP--LGVHLPFVGYSYSCMALRDSE 409
           DT  FD      T  ++      G P   G H  F G+S+    L + +
Sbjct: 356 DTFYFDTEFTSRTPKDS-----PGIPPSAGAHQLFRGFSFVATGLMEDD 399



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 87/269 (32%), Positives = 133/269 (49%), Gaps = 32/269 (11%)

Query: 69  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN-GD 127
           D + + + IG G++SE      K T   YA+K+++K    KR       EE ++L+  G 
Sbjct: 425 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK---SKRDP----SEEIEILLRYGQ 477

Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSK---FGERIPAEMARFYLAEIVMAID 184
              I  L   + D  ++YLV E   GG+LL  + +   F ER     A F L  I   ++
Sbjct: 478 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSER----EASFVLHTIGKTVE 533

Query: 185 SVHRLGYVHRDIKPDNIL-LDRCGH---IRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
            +H  G VHRD+KP NIL +D  G+   +R+ DFG   +LRA+  +  +    T ++++P
Sbjct: 534 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGL-LMTPCYTANFVAP 592

Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFY---ADSTAETYGKIVHYKEHL 297
           E+L+  G       Y   CD W+LG+  Y M  G TPF    +D+  E   +I   K  L
Sbjct: 593 EVLKRQG-------YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 645

Query: 298 SLPLVDEGVPEEARDFIQRLL-CPPETRL 325
           S    +  V E A+D + ++L   P  RL
Sbjct: 646 SGGNWNT-VSETAKDLVSKMLHVDPHQRL 673


>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
           isoform a [Homo sapiens]
          Length = 735

 Score =  187 bits (475), Expect = 2e-47
 Identities = 122/349 (34%), Positives = 185/349 (53%), Gaps = 30/349 (8%)

Query: 71  FEILKVIGRGAFSEVAVVKM---KQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 127
           FE+LKV+G+G+F +V +V+      +G +YAMK++ K  +  R  V   + ERD+L + +
Sbjct: 62  FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRT-KMERDILADVN 120

Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVH 187
             ++ +LH+AFQ E  LYL++++  GGDL T LSK       E  +FYLAE+ + +D +H
Sbjct: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALGLDHLH 179

Query: 188 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 247
            LG ++RD+KP+NILLD  GHI+L DFG   K   D   ++    GT +Y++PE++   G
Sbjct: 180 SLGIIYRDLKPENILLDEEGHIKLTDFG-LSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 238

Query: 248 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVP 307
                  +    DWW+ GV  +EM  G  PF      ET   I+  K  L +P   + + 
Sbjct: 239 -------HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL--KAKLGMP---QFLS 286

Query: 308 EEARDFIQRLL-CPPETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGAT 362
            EA+  ++ L    P  RLG G  GA + + H F+  +DW+ L  R+  PPF P      
Sbjct: 287 TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPD 346

Query: 363 DTCNFDLVEDGLTAMETLSDIREGAP--LGVHLPFVGYSYSCMALRDSE 409
           DT  FD      T  ++      G P   G H  F G+S+    L + +
Sbjct: 347 DTFYFDTEFTSRTPKDS-----PGIPPSAGAHQLFRGFSFVATGLMEDD 390



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 87/269 (32%), Positives = 133/269 (49%), Gaps = 32/269 (11%)

Query: 69  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN-GD 127
           D + + + IG G++SE      K T   YA+K+++K    KR       EE ++L+  G 
Sbjct: 416 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK---SKRDP----SEEIEILLRYGQ 468

Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSK---FGERIPAEMARFYLAEIVMAID 184
              I  L   + D  ++YLV E   GG+LL  + +   F ER     A F L  I   ++
Sbjct: 469 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSER----EASFVLHTIGKTVE 524

Query: 185 SVHRLGYVHRDIKPDNIL-LDRCGH---IRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
            +H  G VHRD+KP NIL +D  G+   +R+ DFG   +LRA+  +  +    T ++++P
Sbjct: 525 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGL-LMTPCYTANFVAP 583

Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFY---ADSTAETYGKIVHYKEHL 297
           E+L+  G       Y   CD W+LG+  Y M  G TPF    +D+  E   +I   K  L
Sbjct: 584 EVLKRQG-------YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 636

Query: 298 SLPLVDEGVPEEARDFIQRLL-CPPETRL 325
           S    +  V E A+D + ++L   P  RL
Sbjct: 637 SGGNWNT-VSETAKDLVSKMLHVDPHQRL 664


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,153,419
Number of Sequences: 37866
Number of extensions: 1359789
Number of successful extensions: 9501
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 674
Number of HSP's successfully gapped in prelim test: 417
Number of HSP's that attempted gapping in prelim test: 6365
Number of HSP's gapped (non-prelim): 2058
length of query: 624
length of database: 18,247,518
effective HSP length: 108
effective length of query: 516
effective length of database: 14,157,990
effective search space: 7305522840
effective search space used: 7305522840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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