Search of human proteins with 126091095

Search of human proteins with 126091095

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
         (639 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s...  1300   0.0  
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa...  1162   0.0  
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s...  1146   0.0  
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s...   988   0.0  
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s...   478   e-135
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s...   478   e-135
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom...   467   e-131
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]         462   e-130
gi|4885583 Rho-associated, coiled-coil containing protein kinase...   349   4e-96
gi|41872583 Rho-associated, coiled-coil containing protein kinas...   343   2e-94
gi|32698688 citron [Homo sapiens]                                     317   2e-86
gi|24307971 serine/threonine kinase 38 like [Homo sapiens]            275   9e-74
gi|6005814 serine/threonine kinase 38 [Homo sapiens]                  274   2e-73
gi|150170729 microtubule associated serine/threonine kinase 3 [H...   218   1e-56
gi|112363080 microtubule associated serine/threonine kinase 2 [H...   217   3e-56
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho...   213   4e-55
gi|148727255 microtubule associated serine/threonine kinase fami...   209   6e-54
gi|28557781 protein kinase C, eta [Homo sapiens]                      196   4e-50
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]   196   4e-50
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho...   196   6e-50
gi|4885563 protein kinase C, epsilon [Homo sapiens]                   196   7e-50
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph...   196   7e-50
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha...   196   7e-50
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ...   195   9e-50
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta...   195   9e-50
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   189   7e-48
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   189   7e-48
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   189   9e-48
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   189   9e-48
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   189   9e-48

>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
           sapiens]
          Length = 639

 Score = 1300 bits (3364), Expect = 0.0
 Identities = 639/639 (100%), Positives = 639/639 (100%)

Query: 1   MGGHFWPPEPYTVFMWGSPWEADSPRVKLRGREKGRQTEGGAFPLVSSALSGDPRFFSPT 60
           MGGHFWPPEPYTVFMWGSPWEADSPRVKLRGREKGRQTEGGAFPLVSSALSGDPRFFSPT
Sbjct: 1   MGGHFWPPEPYTVFMWGSPWEADSPRVKLRGREKGRQTEGGAFPLVSSALSGDPRFFSPT 60

Query: 61  TPPAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKR 120
           TPPAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKR
Sbjct: 61  TPPAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKR 120

Query: 121 GEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE 180
           GEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE
Sbjct: 121 GEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE 180

Query: 181 MARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLV 240
           MARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLV
Sbjct: 181 MARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLV 240

Query: 241 AVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI 300
           AVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI
Sbjct: 241 AVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI 300

Query: 301 VHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDS 360
           VHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDS
Sbjct: 301 VHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDS 360

Query: 361 VPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMAL 420
           VPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMAL
Sbjct: 361 VPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMAL 420

Query: 421 RDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRE 480
           RDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRE
Sbjct: 421 RDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRE 480

Query: 481 LQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 540
           LQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAE
Sbjct: 481 LQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 540

Query: 541 GATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALS 600
           GATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALS
Sbjct: 541 GATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALS 600

Query: 601 LLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP 639
           LLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
Sbjct: 601 LLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP 639


>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
           sapiens]
          Length = 629

 Score = 1162 bits (3006), Expect = 0.0
 Identities = 576/576 (100%), Positives = 576/576 (100%)

Query: 64  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
           AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV
Sbjct: 54  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 113

Query: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
           SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR
Sbjct: 114 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 173

Query: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
           FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG
Sbjct: 174 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 233

Query: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
           TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY
Sbjct: 234 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 293

Query: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
           KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP
Sbjct: 294 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353

Query: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDS 423
           FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDS
Sbjct: 354 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDS 413

Query: 424 EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE 483
           EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE
Sbjct: 414 EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE 473

Query: 484 ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT 543
           ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT
Sbjct: 474 ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT 533

Query: 544 AVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLL 603
           AVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLL
Sbjct: 534 AVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLL 593

Query: 604 FAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP 639
           FAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
Sbjct: 594 FAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP 629


>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
           sapiens]
          Length = 624

 Score = 1146 bits (2964), Expect = 0.0
 Identities = 571/576 (99%), Positives = 571/576 (99%), Gaps = 5/576 (0%)

Query: 64  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
           AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV
Sbjct: 54  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 113

Query: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
           SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR
Sbjct: 114 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 173

Query: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
           FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG
Sbjct: 174 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 233

Query: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
           TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY
Sbjct: 234 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 293

Query: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
           KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP
Sbjct: 294 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353

Query: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDS 423
           FTPDFEGATDTCNFDLVEDGLTAM     ETLSDIREGAPLGVHLPFVGYSYSCMALRDS
Sbjct: 354 FTPDFEGATDTCNFDLVEDGLTAM-----ETLSDIREGAPLGVHLPFVGYSYSCMALRDS 408

Query: 424 EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE 483
           EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE
Sbjct: 409 EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE 468

Query: 484 ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT 543
           ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT
Sbjct: 469 ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT 528

Query: 544 AVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLL 603
           AVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLL
Sbjct: 529 AVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLL 588

Query: 604 FAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP 639
           FAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
Sbjct: 589 FAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP 624


>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
           sapiens]
          Length = 625

 Score =  988 bits (2553), Expect = 0.0
 Identities = 492/501 (98%), Positives = 493/501 (98%), Gaps = 5/501 (0%)

Query: 64  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
           AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV
Sbjct: 54  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 113

Query: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
           SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR
Sbjct: 114 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 173

Query: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
           FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG
Sbjct: 174 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 233

Query: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
           TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY
Sbjct: 234 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 293

Query: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
           KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP
Sbjct: 294 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353

Query: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDS 423
           FTPDFEGATDTCNFDLVEDGLTAM     ETLSDIREGAPLGVHLPFVGYSYSCMALRDS
Sbjct: 354 FTPDFEGATDTCNFDLVEDGLTAM-----ETLSDIREGAPLGVHLPFVGYSYSCMALRDS 408

Query: 424 EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE 483
           EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE
Sbjct: 409 EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE 468

Query: 484 ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT 543
           ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT
Sbjct: 469 ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT 528

Query: 544 AVTGVPSPRATDPPSHLDGPP 564
           AVTGVPSPRATDPPSH+   P
Sbjct: 529 AVTGVPSPRATDPPSHMAPRP 549


>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
           sapiens]
          Length = 1719

 Score =  478 bits (1230), Expect = e-135
 Identities = 257/497 (51%), Positives = 338/497 (68%), Gaps = 33/497 (6%)

Query: 64  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
           A+P   ++K++RL R+DFEILKVIGRGAF EVAVVK+K   +V+AMKI+NKW+MLKR E 
Sbjct: 60  AKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAET 119

Query: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
           +CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MAR
Sbjct: 120 ACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAR 179

Query: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
           FYLAE+V+AIDSVH+L YVHRDIKPDNIL+D  GHIRLADFGSCLKL  DGTV+S VAVG
Sbjct: 180 FYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVG 239

Query: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
           TPDY+SPEILQA+    G G YGPECDWW+LGV  YEM YG+TPFYA+S  ETYGKI+++
Sbjct: 240 TPDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH 297

Query: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
           KE    P     V E A+D I+RL+C  E RLG+ G  DF+ HPFF G+DWD +R+   P
Sbjct: 298 KERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAP 357

Query: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSY-SCMALRD 422
           + P+    TDT NFD+ +D L        ET+      A  G HLPFVG++Y S   L D
Sbjct: 358 YIPEVSSPTDTSNFDVDDDCLK-----NSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSD 412

Query: 423 SE----VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAE 475
                   GPT ++L+   ++ L+ ++   + E  +   + E  E++          E+ 
Sbjct: 413 RSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQEST 466

Query: 476 VTLRELQEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAH 526
            T++ LQ +  +  LT       ++L  E+E +R   T++ +   QL EA A  ++L+  
Sbjct: 467 QTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDA 526

Query: 527 VRQL---QERMELLQAE 540
            RQ+   +++++ LQ E
Sbjct: 527 FRQIKAYEKQIKTLQQE 543


>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
           sapiens]
          Length = 1638

 Score =  478 bits (1230), Expect = e-135
 Identities = 257/497 (51%), Positives = 338/497 (68%), Gaps = 33/497 (6%)

Query: 64  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
           A+P   ++K++RL R+DFEILKVIGRGAF EVAVVK+K   +V+AMKI+NKW+MLKR E 
Sbjct: 60  AKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAET 119

Query: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
           +CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MAR
Sbjct: 120 ACFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMAR 179

Query: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
           FYLAE+V+AIDSVH+L YVHRDIKPDNIL+D  GHIRLADFGSCLKL  DGTV+S VAVG
Sbjct: 180 FYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVG 239

Query: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
           TPDY+SPEILQA+    G G YGPECDWW+LGV  YEM YG+TPFYA+S  ETYGKI+++
Sbjct: 240 TPDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH 297

Query: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
           KE    P     V E A+D I+RL+C  E RLG+ G  DF+ HPFF G+DWD +R+   P
Sbjct: 298 KERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAP 357

Query: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSY-SCMALRD 422
           + P+    TDT NFD+ +D L        ET+      A  G HLPFVG++Y S   L D
Sbjct: 358 YIPEVSSPTDTSNFDVDDDCLK-----NSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSD 412

Query: 423 SE----VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAE 475
                   GPT ++L+   ++ L+ ++   + E  +   + E  E++          E+ 
Sbjct: 413 RSCLRVTAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQEST 466

Query: 476 VTLRELQEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAH 526
            T++ LQ +  +  LT       ++L  E+E +R   T++ +   QL EA A  ++L+  
Sbjct: 467 QTVQALQYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDA 526

Query: 527 VRQL---QERMELLQAE 540
            RQ+   +++++ LQ E
Sbjct: 527 FRQIKAYEKQIKTLQQE 543


>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
           sapiens]
          Length = 1551

 Score =  467 bits (1202), Expect = e-131
 Identities = 256/528 (48%), Positives = 329/528 (62%), Gaps = 58/528 (10%)

Query: 64  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
           A P V ++KE+RLQRDDFEILKVIGRGAF EV VV+ + TGQ++AMK+++KW+MLKR E 
Sbjct: 54  ASPFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAET 113

Query: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
           +CFREERDVLV GD RW+T LH+AFQDE YLYLVM+YY GGDLLTLLS+F +R+P E+A+
Sbjct: 114 ACFREERDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQ 173

Query: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
           FYLAE+V+AI S+H+LGYVHRD+KPDN+LLD  GHIRLADFGSCL+L  +G V S VAVG
Sbjct: 174 FYLAEMVLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVG 233

Query: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
           TPDY+SPEILQA+    G G YGP+CDWW+LGV AYE+ +G+TPFYA+S  ETYGKI+++
Sbjct: 234 TPDYISPEILQAM--EEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNH 291

Query: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
           ++HL  P     VP  A+D I++LLC  E RLGRGG  DFR HPFF G+DW+ L  S  P
Sbjct: 292 EDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAP 351

Query: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSC------ 417
           + P+  G  DT NFD+ +D L         TL     GA  G HLPFVG++Y+       
Sbjct: 352 YIPELRGPMDTSNFDVDDDTL-----NHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPE 406

Query: 418 ------------MALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSP-QDETAEV--- 461
                       +   + E    +    EA      H +   L   V   +D   E+   
Sbjct: 407 SSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRD 466

Query: 462 --------AVPAAVPAAEAEAEVTL----RELQE----------------ALEEEVLTRQ 493
                     PA  P  +++    L    REL E                  +EE+L R 
Sbjct: 467 KASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRL 526

Query: 494 SLSREME-AIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 540
             ++E E A  +  +  +SQL EA A  R+LEA V  L  ++  LQ +
Sbjct: 527 QEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQ 574



 Score = 33.5 bits (75), Expect = 0.62
 Identities = 16/55 (29%), Positives = 30/55 (54%)

Query: 480 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERM 534
           ELQ ALE E+  +Q L   +  ++        +L+EAE +++ L+  +  L+E +
Sbjct: 744 ELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL 798


>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
          Length = 1711

 Score =  462 bits (1188), Expect = e-130
 Identities = 251/510 (49%), Positives = 337/510 (66%), Gaps = 42/510 (8%)

Query: 64  AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
           A+P    +KE++L R+DFEI+KVIGRGAF EVAVVKMK T ++YAMKI+NKW+MLKR E 
Sbjct: 59  AKPFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAET 118

Query: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
           +CFREERDVLVNGD +WIT LH+AFQDEN+LYLVM+YYVGGDLLTLLSKF +++P +MAR
Sbjct: 119 ACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMAR 178

Query: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
           FY+ E+V+AIDS+H+L YVHRDIKPDN+LLD  GHIRLADFGSCLK+  DGTV+S VAVG
Sbjct: 179 FYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVG 238

Query: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
           TPDY+SPEILQA+    G G YGPECDWW+LGV  YEM YG+TPFYA+S  ETYGKI+++
Sbjct: 239 TPDYISPEILQAM--EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH 296

Query: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
           +E    P     V EEA+D IQRL+C  E RLG+ G  DF+ H FF GL+W+ +R+   P
Sbjct: 297 EERFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAP 356

Query: 364 FTPDFEGATDTCNFDLVEDGL--TAMVSGGGETLSDIREGAPLGVHLPFVGYSY---SCM 418
           + PD    +DT NFD+ +D L  T ++  G  T          G+HLPF+G+++   SC 
Sbjct: 357 YIPDVSSPSDTSNFDVDDDVLRNTEILPPGSHT-------GFSGLHLPFIGFTFTTESCF 409

Query: 419 A--------------LRDSEVPGPT--PMELEAEQLLEPHVQAPSLEPSVSPQDETAEV- 461
           +               +D +V       +++EA +     ++   LE S   Q+ T  V 
Sbjct: 410 SDRGSLKSIMQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQ 469

Query: 462 ---AVPAAVPAAEAEAEV-TLRELQEALEEEVLTRQSLSREME---AIRTDNQNFASQLR 514
                  A+  +  + E+  L E  E L+ ++     L R++E   A+R + ++   +LR
Sbjct: 470 SLHGSSRALSNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLR 529

Query: 515 EAEARNR----DLEAHVRQLQERMELLQAE 540
             E ++R    + E   +QL E  E L+++
Sbjct: 530 GLEKQHRVVRQEKEELHKQLVEASERLKSQ 559



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 26/76 (34%), Positives = 43/76 (56%), Gaps = 4/76 (5%)

Query: 480 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQA 539
           ELQ ALE E+  +Q +  E+  ++  N    S+L+++EA+NR+L   +  L+++ME    
Sbjct: 878 ELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKME---- 933

Query: 540 EGATAVTGVPSPRATD 555
           E   A TG+  P   D
Sbjct: 934 EKFRADTGLKLPDFQD 949


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
           [Homo sapiens]
          Length = 1354

 Score =  349 bits (896), Expect = 4e-96
 Identities = 191/511 (37%), Positives = 296/511 (57%), Gaps = 48/511 (9%)

Query: 70  RLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREE 129
           +++++R++ +D+E++KVIGRGAF EV +V+ K T +VYAMK+++K++M+KR + + F EE
Sbjct: 65  KIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEE 124

Query: 130 RDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEI 189
           RD++   +  W+ QL +AFQD+ YLY+VMEY  GGDL+ L+S +   +P + ARFY AE+
Sbjct: 125 RDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEV 182

Query: 190 VMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLS 249
           V+A+D++H +G++HRD+KPDN+LLD+ GH++LADFG+C+K+  +G VR   AVGTPDY+S
Sbjct: 183 VLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYIS 242

Query: 250 PEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSL 309
           PE+L++ G   G G YG ECDWW++GVF YEM  G TPFYADS   TY KI+++K  L+ 
Sbjct: 243 PEVLKSQG---GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTF 299

Query: 310 PLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPD 367
           P  D  + +EA++ I   L   E RLGR G  + + H FF      W+ LRD+V P  PD
Sbjct: 300 P-DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPD 358

Query: 368 FEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYS-YSCMALRDSEVP 426
                DT NFD +E+       G  ET    +  A +G  LPFVG++ YS      S  P
Sbjct: 359 LSSDIDTSNFDDLEED-----KGEEETFPIPK--AFVGNQLPFVGFTYYSNRRYLSSANP 411

Query: 427 GPTPMELEAEQLLEPHVQAP------------SLEPSVSPQDETAEVAVPAAVPAAEAEA 474
                   A++ L+  +Q               L+  +  +  T+ + +   +   + E 
Sbjct: 412 NDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEG 471

Query: 475 --------------------EVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLR 514
                               +  + E Q   E+E   R+++  E+  ++   ++     +
Sbjct: 472 NQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQ 531

Query: 515 EAEARNRDLEAHVRQLQERMELLQAEGATAV 545
            ++  N  L    +QL+E  +LL+ E  TAV
Sbjct: 532 NSQLANEKLSQLQKQLEEANDLLRTESDTAV 562


>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
           [Homo sapiens]
          Length = 1388

 Score =  343 bits (881), Expect = 2e-94
 Identities = 187/480 (38%), Positives = 283/480 (58%), Gaps = 44/480 (9%)

Query: 65  EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 124
           E IV +++ ++++ +D++++KVIGRGAF EV +V+ K + +VYAMK+++K++M+KR + +
Sbjct: 76  EKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSA 135

Query: 125 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 184
            F EERD++   +  W+ QL +AFQD+ YLY+VMEY  GGDL+ L+S +   +P + A+F
Sbjct: 136 FFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKF 193

Query: 185 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 244
           Y AE+V+A+D++H +G +HRD+KPDN+LLD+ GH++LADFG+C+K+   G V    AVGT
Sbjct: 194 YTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGT 253

Query: 245 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 304
           PDY+SPE+L++ G   G G YG ECDWW++GVF YEM  G TPFYADS   TY KI+ +K
Sbjct: 254 PDYISPEVLKSQG---GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHK 310

Query: 305 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVP 362
             L  P  D  + + A++ I   L   E RLGR G  + R HPFF      WD +R++  
Sbjct: 311 NSLCFP-EDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAA 369

Query: 363 PFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRD 422
           P  P+     D+ NFD +ED       G  ET    +  A +G  LPF+G++Y       
Sbjct: 370 PVVPELSSDIDSSNFDDIEDD-----KGDVETFPIPK--AFVGNQLPFIGFTY------- 415

Query: 423 SEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQ 482
                        E LL     +PS   + S Q    E            E +  L  L+
Sbjct: 416 -----------YRENLLLS--DSPSCRETDSIQSRKNE---------ESQEIQKKLYTLE 453

Query: 483 EALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGA 542
           E L  E+  ++ L ++ +++ T  +  A +L E     + +E+ +RQL+    LLQ + A
Sbjct: 454 EHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA 513


>gi|32698688 citron [Homo sapiens]
          Length = 2027

 Score =  317 bits (813), Expect = 2e-86
 Identities = 187/480 (38%), Positives = 278/480 (57%), Gaps = 38/480 (7%)

Query: 68  VVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFR 127
           +  L+E++    DFE+  ++G G F+EV VV+ K TG +YAMK+M K  +L + +VS F 
Sbjct: 84  IAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFE 143

Query: 128 EERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLA 187
           EER++L      WI QL +AFQD+N+LYLVMEY  GGDLL+LL+++ +++   + +FYLA
Sbjct: 144 EERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLA 203

Query: 188 EIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDY 247
           E+++A+ SVH +GYVHRDIKP+NIL+DR GHI+L DFGS  K+ ++  V + + +GTPDY
Sbjct: 204 ELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDY 263

Query: 248 LSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHL 307
           ++PE+L  V  G G G+YG +CDWW++GV AYEM YG++PF   ++A T+  I++++  L
Sbjct: 264 MAPEVL-TVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFL 322

Query: 308 SLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPD 367
             P  D  V  +  D IQ LLC  + RL   G      HPFF  +DW+ +R+S PPF P 
Sbjct: 323 KFP-DDPKVSSDFLDLIQSLLCGQKERLKFEG---LCCHPFFSKIDWNNIRNSPPPFVPT 378

Query: 368 FEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYS----CMALRDS 423
            +   DT NFD  E    + VS     LS        G  LPFVG+SYS     +   +S
Sbjct: 379 LKSDDDTSNFD--EPEKNSWVSSSPCQLS---PSGFSGEELPFVGFSYSKALGILGRSES 433

Query: 424 EVPG---PTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRE 480
            V G   P       ++LL   +++  L+ S     +  +         +E EA ++ +E
Sbjct: 434 VVSGLDSPAKTSSMEKKLL---IKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKE 490

Query: 481 LQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 540
           ++    E   T++SL           Q+ A+ + E  +  R LE      Q RME+ Q +
Sbjct: 491 VELKASE---TQRSLL---------EQDLATYITECSSLKRSLE------QARMEVSQED 532



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 473 EAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQE 532
           E E  LRE+    EE+ L    L R++  ++   Q   SQL   +A    LE+ +RQ + 
Sbjct: 853 ELETRLREVSLEHEEQKL---ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT 909

Query: 533 RMELLQAEGATAVTGVPSPR 552
            +E   AE    +  + + R
Sbjct: 910 ELEETTAEAEEEIQALTAHR 929



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 5/82 (6%)

Query: 457 ETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIR---TDNQNFASQL 513
           E  E AV A+  A E    +  R+ +E  E E+   Q+     E IR    + +    + 
Sbjct: 643 EKLEKAVKASTEATELLQNI--RQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKH 700

Query: 514 REAEARNRDLEAHVRQLQERME 535
           REA+   + LE H++Q ++  E
Sbjct: 701 REAQVSAQHLEVHLKQKEQHYE 722



 Score = 30.8 bits (68), Expect = 4.0
 Identities = 28/97 (28%), Positives = 41/97 (42%), Gaps = 5/97 (5%)

Query: 436 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 495
           EQ LE   Q   L+ S+  ++         A+ AA A  E  LR+ +  LEE     +  
Sbjct: 867 EQKLELKRQLTELQLSLQERESQL-----TALQAARAALESQLRQAKTELEETTAEAEEE 921

Query: 496 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQE 532
            + + A R + Q     LR +     DLE  + QL E
Sbjct: 922 IQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 958


>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
          Length = 464

 Score =  275 bits (703), Expect = 9e-74
 Identities = 141/344 (40%), Positives = 206/344 (59%), Gaps = 43/344 (12%)

Query: 69  VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 128
           +RLK  RL  DDFE LKVIGRGAF EV +V+ K TG +YAMKI+ K DML++ +V+  R 
Sbjct: 78  LRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRA 137

Query: 129 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 188
           ERD+LV  D  W+ ++ ++FQD+  LYL+ME+  GGD++TLL K  + +  E  +FY++E
Sbjct: 138 ERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISE 196

Query: 189 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 232
            V+AID++H+LG++HRDIKPDN+LLD  GH++L+DFG C  L+                +
Sbjct: 197 TVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPS 256

Query: 233 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 274
           D + +++                    VGTPDY++PE+    G       Y   CDWW+L
Sbjct: 257 DFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 309

Query: 275 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 334
           GV  YEM  G  PF +++  ETY K++++KE L  P  +  + E+A+D I R     E R
Sbjct: 310 GVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFP-PEVPISEKAKDLILRFCIDSENR 368

Query: 335 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 378
           +G  G  + + HPFF G+DW+ +R+       + +   DT NFD
Sbjct: 369 IGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFD 412


>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
          Length = 465

 Score =  274 bits (701), Expect = 2e-73
 Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)

Query: 69  VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 128
           +RLK  RL  +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V   R 
Sbjct: 77  LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136

Query: 129 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 188
           ERD+LV  D  W+ ++ ++FQD+  LYL+ME+  GGD++TLL K  + +  E  +FY+AE
Sbjct: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195

Query: 189 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 232
            V+AIDS+H+LG++HRDIKPDN+LLD  GH++L+DFG C  L+                +
Sbjct: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255

Query: 233 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 274
           D T +++                    VGTPDY++PE+    G       Y   CDWW+L
Sbjct: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308

Query: 275 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 334
           GV  YEM  G  PF +++  ETY K++++KE L+ P  +  + E+A+D I R  C  E R
Sbjct: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367

Query: 335 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 378
           +G  G  + +++ FF G+DW+ +R+     + + +   DT NFD
Sbjct: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411


>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
           sapiens]
          Length = 1309

 Score =  218 bits (556), Expect = 1e-56
 Identities = 126/352 (35%), Positives = 189/352 (53%), Gaps = 26/352 (7%)

Query: 58  SPTTPPAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDM 117
           +P +P +  +V + +    +  DFE +K+I  GA+  V +V+ + T Q +A+K +NK ++
Sbjct: 345 APESPESRALVGQSRRKPCE-SDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNL 403

Query: 118 LKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERI 177
           + R ++     ERD+L   +  ++  +  +F+   +L +VMEY  GGD  TLL   G  +
Sbjct: 404 ILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP-L 462

Query: 178 PAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFG-SCLKLRADGT- 235
           P +MAR Y AE V+A++ +H  G VHRD+KPDN+L+   GHI+L DFG S + L +  T 
Sbjct: 463 PVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATN 522

Query: 236 ---------VRSLV---AVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFY 283
                     R  +     GTP+Y++PE++   G       YG   DWWA+GV  YE   
Sbjct: 523 LYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQG-------YGKPVDWWAMGVVLYEFLV 575

Query: 284 GQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGD 342
           G  PF+ D+  E +G++V   + +  P  DE +P +A+D I RLL   P  RLG GG  +
Sbjct: 576 GCVPFFGDTPEELFGQVV--SDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHE 633

Query: 343 FRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGET 394
            + HPFF  LDW GL      F P  E   DT  FD   +    + S   ET
Sbjct: 634 VKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFDTRSERYRHLGSEDDET 685


>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
           sapiens]
          Length = 1798

 Score =  217 bits (552), Expect = 3e-56
 Identities = 131/383 (34%), Positives = 195/383 (50%), Gaps = 37/383 (9%)

Query: 79  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 138
           +DFE +K+I  GA+  V +V+ K T Q +AMK +NK +++ R ++     ERD+L   + 
Sbjct: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569

Query: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 198
            ++  +  +F  + +L +VMEY  GGD  TLL   G  +P +M R Y AE V+A++ +H 
Sbjct: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIG-ALPVDMVRLYFAETVLALEYLHN 628

Query: 199 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 244
            G VHRD+KPDN+L+   GHI+L DFG           +  +   +   R  +     GT
Sbjct: 629 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGT 688

Query: 245 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 304
           P+Y++PE++   G       YG   DWWA+G+  YE   G  PF+ D+  E +G+++   
Sbjct: 689 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 739

Query: 305 EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
           + +  P  DE +P +A+D   +LL   P  RLG G A + + HPFF GLDW GL      
Sbjct: 740 DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAE 799

Query: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLS-----DIREGAPLGVHLPFVGYSYSCM 418
           F P  E   DT  FD   +    M S   E +S     +IR+ +      P     YS M
Sbjct: 800 FIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCS---PRFNKVYSSM 856

Query: 419 ----ALRDSEVPGPTPMELEAEQ 437
                L +   P PT   L  E+
Sbjct: 857 ERLSLLEERRTPPPTKRSLSEEK 879


>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
           sapiens]
          Length = 1570

 Score =  213 bits (542), Expect = 4e-55
 Identities = 158/513 (30%), Positives = 232/513 (45%), Gaps = 49/513 (9%)

Query: 79  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 138
           +DF+ +K+I  GA+  V +V+ + T Q +AMK +NK +++ R ++     ERD+L   + 
Sbjct: 372 NDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 431

Query: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 198
            ++  +  +F+   +L +VMEY  GGD  TLL   G  +P EMAR Y AE V+A++ +H 
Sbjct: 432 PFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGA-LPVEMARMYFAETVLALEYLHN 490

Query: 199 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 244
            G VHRD+KPDN+L+   GHI+L DFG           +  +   +   R  +     GT
Sbjct: 491 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGT 550

Query: 245 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 304
           P+Y++PE++   G       YG   DWWA+G+  YE   G  PF+ D+  E +G+++   
Sbjct: 551 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 601

Query: 305 EHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
           + +  P  DE +P EA+  I  LL   P  RLG GGA + + H FF  LDW GL      
Sbjct: 602 DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAE 661

Query: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVH-----LPFVGYSYSCM 418
           F P  E   DT  FD   D    + S   +   D  E  P+ +       P     YS M
Sbjct: 662 FIPHLESEDDTSYFDTRSDRYHHVNSYDED---DTTEEEPVEIRQFSSCSPRFSKVYSSM 718

Query: 419 ALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTL 478
                  P  TP+        EP  + P  E  V+ + E                 E+  
Sbjct: 719 EQLSQHEP-KTPVAAAGSSKREPSTKGP--EEKVAGKREGLGGLTLREKTWRGGSPEIKR 775

Query: 479 RELQEA--LEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNR-----------DLEA 525
               EA  LE E        R   A+   ++  A Q  E EAR R            L+A
Sbjct: 776 FSASEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDA 835

Query: 526 HVRQLQERMELLQAEGATAVTGVPSPRATDPPS 558
              + + + E   + G +  T  P P    PPS
Sbjct: 836 RAPKEETQGEGTSSAGDSEATDRPRPGDLCPPS 868


>gi|148727255 microtubule associated serine/threonine kinase family
           member 4 isoform a [Homo sapiens]
          Length = 2434

 Score =  209 bits (532), Expect = 6e-54
 Identities = 113/317 (35%), Positives = 173/317 (54%), Gaps = 25/317 (7%)

Query: 77  QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNG 136
           +  DFE +K+I  GA+  V  V+ K++ Q +AMK +NK +++ R ++     ERD+L   
Sbjct: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436

Query: 137 DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSV 196
           +  ++  ++ +F+   +L +VMEY  GGD  TL+   G  +P +MAR Y AE V+A++ +
Sbjct: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGP-LPVDMARMYFAETVLALEYL 495

Query: 197 HRLGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AV 242
           H  G VHRD+KPDN+L+   GHI+L DFG           +  +   +   R  +     
Sbjct: 496 HNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVC 555

Query: 243 GTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVH 302
           GTP+Y++PE++   G       YG   DWWA+G+  YE   G  PF+ D+  E +G+++ 
Sbjct: 556 GTPEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI- 607

Query: 303 YKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSV 361
             + ++ P  DE  P +A+D I  LL   P  RLG GGA + + H FF  LDW+ L    
Sbjct: 608 -SDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQK 666

Query: 362 PPFTPDFEGATDTCNFD 378
             F P  E   DT  FD
Sbjct: 667 AEFIPQLESEDDTSYFD 683


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  196 bits (499), Expect = 4e-50
 Identities = 117/311 (37%), Positives = 177/311 (56%), Gaps = 21/311 (6%)

Query: 75  RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVL- 133
           RL  D+FE ++V+G+G+F +V + ++K+TG +YA+K++ K  +L+  +V C   E+ +L 
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408

Query: 134 VNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 193
           +  +  ++TQL   FQ  + L+ VME+  GGDL+  + K   R     ARFY AEI+ A+
Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQK-SRRFDEARARFYAAEIISAL 467

Query: 194 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 253
             +H  G ++RD+K DN+LLD  GH +LADFG C +   +G V +    GTPDY++PEIL
Sbjct: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNG-VTTATFCGTPDYIAPEIL 526

Query: 254 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD 313
           Q +        YGP  DWWA+GV  YEM  G  PF A++  + +  I++  + +  P   
Sbjct: 527 QEM-------LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN--DEVVYP--- 574

Query: 314 EGVPEEARDFIQRLLCP-PETRLG---RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPD 367
             + E+A   ++  +   P  RLG   +GG      HPFF  +DW  L  R   PPF P 
Sbjct: 575 TWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPR 634

Query: 368 FEGATDTCNFD 378
            +   D  NFD
Sbjct: 635 IKSREDVSNFD 645


>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
          Length = 745

 Score =  196 bits (499), Expect = 4e-50
 Identities = 123/321 (38%), Positives = 178/321 (55%), Gaps = 23/321 (7%)

Query: 66  PIVVRLKEVRLQRD--DFEILKVIGRGAFSEVAVVKMK---QTGQVYAMKIMNKWDMLKR 120
           PI   +KE   + D   FE+LKV+G+G+F +V +V+ K     GQ+YAMK++ K  +  R
Sbjct: 56  PITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVR 115

Query: 121 GEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE 180
             V   + ERD+LV  +  +I +LH+AFQ E  LYL++++  GGD+ T LSK       E
Sbjct: 116 DRVRT-KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEE 173

Query: 181 MARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLV 240
             +FYLAE+ +A+D +H+LG V+RD+KP+NILLD  GHI+L DFG   K   D   ++  
Sbjct: 174 DVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG-LSKESVDQEKKAYS 232

Query: 241 AVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI 300
             GT +Y++PE++   G       +    DWW+ GV  +EM  G  PF      ET   I
Sbjct: 233 FCGTVEYMAPEVVNRRG-------HSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMI 285

Query: 301 VHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGL-- 357
           +  K  L +P   + +  EA+  ++ L    P  RLG  G  + + H FF  +DWD L  
Sbjct: 286 L--KAKLGMP---QFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYK 340

Query: 358 RDSVPPFTPDFEGATDTCNFD 378
           R+  PPF P      DT  FD
Sbjct: 341 REVQPPFKPASGKPDDTFCFD 361



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 79/254 (31%), Positives = 121/254 (47%), Gaps = 27/254 (10%)

Query: 43  FPLVSSALSGDPRFFSPTTPPAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQ 102
           F  V+++++ + +    T+    PIV          + +E+ + IG G++S         
Sbjct: 388 FSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHAT 447

Query: 103 TGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN-GDRRWITQLHFAFQDENYLYLVMEYY 161
           T   +A+KI++K    KR       EE ++L+  G    I  L   F D  Y+YLV +  
Sbjct: 448 TNMEFAVKIIDK---SKRDP----SEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLM 500

Query: 162 VGGDLLTLLSK---FGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNIL-LDRCG 217
            GG+LL  + K   F ER  +++    L  I   +D +H  G VHRD+KP NIL +D   
Sbjct: 501 KGGELLDRILKQKCFSEREASDI----LYVISKTVDYLHCQGVVHRDLKPSNILYMDESA 556

Query: 218 H---IRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 274
               IR+ DFG   +LR +  +  L    T ++++PE+L   G       Y   CD W+L
Sbjct: 557 SADSIRICDFGFAKQLRGENGLL-LTPCYTANFVAPEVLMQQG-------YDAACDIWSL 608

Query: 275 GVFAYEMFYGQTPF 288
           GV  Y M  G TPF
Sbjct: 609 GVLFYTMLAGYTPF 622


>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
           sapiens]
          Length = 351

 Score =  196 bits (498), Expect = 6e-50
 Identities = 113/309 (36%), Positives = 171/309 (55%), Gaps = 22/309 (7%)

Query: 79  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 138
           D FE L+ +G G+F  V +V+ ++TG  YAMKI+NK  ++K  +V     E+ +L   D 
Sbjct: 42  DQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDF 101

Query: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 198
            ++ +L F+F+D +YLYLVMEY  GG++ + L + G R     A FY A++V+A+  +H 
Sbjct: 102 PFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVG-RFSEPHACFYAAQVVLAVQYLHS 160

Query: 199 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 258
           L  +HRD+KP+N+L+D+ G++++ DFG   +++     R+    GTP+YL+PEI+ + G 
Sbjct: 161 LDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG- 215

Query: 259 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPE 318
                 Y    DWWALGV  YEM  G  PFYAD   + Y KIV  +      L       
Sbjct: 216 ------YNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKL-----SS 264

Query: 319 EARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDWDGLRDS--VPPFTPDFEGATD 373
           + +  ++ LL    T R G  R G GD + H +F    W  + +     PF P + G  D
Sbjct: 265 DLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGD 324

Query: 374 TCNFDLVED 382
             NFD  E+
Sbjct: 325 ASNFDDYEE 333


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score =  196 bits (497), Expect = 7e-50
 Identities = 116/312 (37%), Positives = 176/312 (56%), Gaps = 22/312 (7%)

Query: 75  RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 134
           RL  D+F  +KV+G+G+F +V + ++K   +VYA+K++ K  +L+  +V C   E+ +L 
Sbjct: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461

Query: 135 NGDRR-WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 193
              +  ++TQL+  FQ ++ L+ VMEY  GGDL+  + +   +     +RFY AE+  A+
Sbjct: 462 LARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQR-SRKFDEPRSRFYAAEVTSAL 520

Query: 194 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 253
             +H+ G ++RD+K DNILLD  GH +LADFG C +   +G V +    GTPDY++PEIL
Sbjct: 521 MFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNG-VTTTTFCGTPDYIAPEIL 579

Query: 254 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD 313
           Q +        YGP  DWWALGV  YEM  GQ PF AD+  + +  I+H  + +  P+  
Sbjct: 580 QEL-------EYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILH--DDVLYPV-- 628

Query: 314 EGVPEEARDFIQRLLCP-PETRLG----RGGAGDFRTHPFFFGLDWDGLRDS--VPPFTP 366
             + +EA   ++  +   P  RLG    + G    + HPFF  +DW  L      PPF P
Sbjct: 629 -WLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKP 687

Query: 367 DFEGATDTCNFD 378
             +   D  NFD
Sbjct: 688 RIKTKRDVNNFD 699


>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 2 [Homo sapiens]
          Length = 343

 Score =  196 bits (497), Expect = 7e-50
 Identities = 114/313 (36%), Positives = 174/313 (55%), Gaps = 30/313 (9%)

Query: 79  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 138
           D FE +K +G G+F  V +VK K+TG  YAMKI++K  ++K  ++     E+ +L   + 
Sbjct: 34  DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 93

Query: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 198
            ++ +L F+F+D + LY+VMEY  GG++ + L + G R     ARFY A+IV+  + +H 
Sbjct: 94  PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHS 152

Query: 199 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 258
           L  ++RD+KP+N+L+D+ G+I++ DFG   +++     R+    GTP+YL+PEI+ + G 
Sbjct: 153 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG- 207

Query: 259 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDE 314
                 Y    DWWALGV  YEM  G  PF+AD   + Y KI    V +  H S      
Sbjct: 208 ------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS------ 255

Query: 315 GVPEEARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFE 369
               + +D ++ LL    T R G  + G  D + H +F   DW  +  R    PF P F+
Sbjct: 256 ---SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFK 312

Query: 370 GATDTCNFDLVED 382
           G  DT NFD  E+
Sbjct: 313 GPGDTSNFDDYEE 325


>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
           isoform 1 [Homo sapiens]
          Length = 351

 Score =  196 bits (497), Expect = 7e-50
 Identities = 114/313 (36%), Positives = 174/313 (55%), Gaps = 30/313 (9%)

Query: 79  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 138
           D FE +K +G G+F  V +VK K+TG  YAMKI++K  ++K  ++     E+ +L   + 
Sbjct: 42  DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101

Query: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 198
            ++ +L F+F+D + LY+VMEY  GG++ + L + G R     ARFY A+IV+  + +H 
Sbjct: 102 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHS 160

Query: 199 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 258
           L  ++RD+KP+N+L+D+ G+I++ DFG   +++     R+    GTP+YL+PEI+ + G 
Sbjct: 161 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG- 215

Query: 259 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDE 314
                 Y    DWWALGV  YEM  G  PF+AD   + Y KI    V +  H S      
Sbjct: 216 ------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS------ 263

Query: 315 GVPEEARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFE 369
               + +D ++ LL    T R G  + G  D + H +F   DW  +  R    PF P F+
Sbjct: 264 ---SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFK 320

Query: 370 GATDTCNFDLVED 382
           G  DT NFD  E+
Sbjct: 321 GPGDTSNFDDYEE 333


>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
           isoform 2 [Homo sapiens]
          Length = 351

 Score =  195 bits (496), Expect = 9e-50
 Identities = 115/313 (36%), Positives = 173/313 (55%), Gaps = 30/313 (9%)

Query: 79  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 138
           +DFE  K +G G+F  V +VK K T Q YAMKI++K  ++K  ++     E+ +L   + 
Sbjct: 42  EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101

Query: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 198
            ++ +L +AF+D + LY+VMEY  GG++ + L + G R     ARFY A+IV+  + +H 
Sbjct: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHS 160

Query: 199 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 258
           L  ++RD+KP+N+L+D  G+I++ DFG   +++     R+    GTP+YL+PEI+ + G 
Sbjct: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG- 215

Query: 259 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDE 314
                 Y    DWWALGV  YEM  G  PF+AD   + Y KI    V +  H S      
Sbjct: 216 ------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS------ 263

Query: 315 GVPEEARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFE 369
               + +D ++ LL    T R G  + G  D +TH +F   DW  +  R    PF P F 
Sbjct: 264 ---SDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFR 320

Query: 370 GATDTCNFDLVED 382
           G+ DT NFD  E+
Sbjct: 321 GSGDTSNFDDYEE 333


>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
           isoform 1 [Homo sapiens]
          Length = 398

 Score =  195 bits (496), Expect = 9e-50
 Identities = 115/313 (36%), Positives = 173/313 (55%), Gaps = 30/313 (9%)

Query: 79  DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 138
           +DFE  K +G G+F  V +VK K T Q YAMKI++K  ++K  ++     E+ +L   + 
Sbjct: 89  EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 148

Query: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 198
            ++ +L +AF+D + LY+VMEY  GG++ + L + G R     ARFY A+IV+  + +H 
Sbjct: 149 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHS 207

Query: 199 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 258
           L  ++RD+KP+N+L+D  G+I++ DFG   +++     R+    GTP+YL+PEI+ + G 
Sbjct: 208 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG- 262

Query: 259 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDE 314
                 Y    DWWALGV  YEM  G  PF+AD   + Y KI    V +  H S      
Sbjct: 263 ------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS------ 310

Query: 315 GVPEEARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFE 369
               + +D ++ LL    T R G  + G  D +TH +F   DW  +  R    PF P F 
Sbjct: 311 ---SDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFR 367

Query: 370 GATDTCNFDLVED 382
           G+ DT NFD  E+
Sbjct: 368 GSGDTSNFDDYEE 380


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  189 bits (480), Expect = 7e-48
 Identities = 129/345 (37%), Positives = 177/345 (51%), Gaps = 25/345 (7%)

Query: 80  DFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV-NGDR 138
           DF+ LKVIG+G+F +V + K K  G+ YA+K++ K  +L R E      ER+VL+ N   
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220

Query: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGER-IPAEMARFYLAEIVMAIDSVH 197
            ++  LH++FQ    LY V+++  GG+L   L +  ER  P   ARFY AEI  A+  +H
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQR--ERSFPEHRARFYAAEIASALGYLH 278

Query: 198 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 257
            +  V+RD+KP+NILLD  GH+ L DFG C +  A     +    GTP+YL+PE+++   
Sbjct: 279 SIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFC-GTPEYLAPEVIR--- 334

Query: 258 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVP 317
                  Y    DWW LG   YEM YG  PFY    AE Y  I+H  + LSL     GV 
Sbjct: 335 ----KQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILH--KPLSL---RPGVS 385

Query: 318 EEARDFIQRLLCPPETRLGRGGAG----DFRTHPFFFGLDWDGL--RDSVPPFTPDFEGA 371
             A   ++ LL   + R  R GA     + + HPFF  L W  L  +   PPF P+  G 
Sbjct: 386 LTAWSILEELL--EKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGP 443

Query: 372 TDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYS 416
            D  NFD      T   S    +   I   + L     FVG+SY+
Sbjct: 444 DDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYA 488


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  189 bits (480), Expect = 7e-48
 Identities = 129/345 (37%), Positives = 177/345 (51%), Gaps = 25/345 (7%)

Query: 80  DFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV-NGDR 138
           DF+ LKVIG+G+F +V + K K  G+ YA+K++ K  +L R E      ER+VL+ N   
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220

Query: 139 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGER-IPAEMARFYLAEIVMAIDSVH 197
            ++  LH++FQ    LY V+++  GG+L   L +  ER  P   ARFY AEI  A+  +H
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQR--ERSFPEHRARFYAAEIASALGYLH 278

Query: 198 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 257
            +  V+RD+KP+NILLD  GH+ L DFG C +  A     +    GTP+YL+PE+++   
Sbjct: 279 SIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFC-GTPEYLAPEVIR--- 334

Query: 258 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVP 317
                  Y    DWW LG   YEM YG  PFY    AE Y  I+H  + LSL     GV 
Sbjct: 335 ----KQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILH--KPLSL---RPGVS 385

Query: 318 EEARDFIQRLLCPPETRLGRGGAG----DFRTHPFFFGLDWDGL--RDSVPPFTPDFEGA 371
             A   ++ LL   + R  R GA     + + HPFF  L W  L  +   PPF P+  G 
Sbjct: 386 LTAWSILEELL--EKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGP 443

Query: 372 TDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYS 416
            D  NFD      T   S    +   I   + L     FVG+SY+
Sbjct: 444 DDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYA 488


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  189 bits (479), Expect = 9e-48
 Identities = 132/376 (35%), Positives = 194/376 (51%), Gaps = 40/376 (10%)

Query: 58  SPTTPPAEPIVVRL---KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNK 114
           +P+ PP+    + L        +  DF  LKVIG+G+F +V + + K     YA+K++ K
Sbjct: 72  NPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQK 131

Query: 115 WDMLKRGEVSCFREERDVLV-NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKF 173
             +LK+ E      ER+VL+ N    ++  LHF+FQ  + LY V++Y  GG+L   L + 
Sbjct: 132 KAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR- 190

Query: 174 GERIPAE-MARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRA 232
            ER   E  ARFY AEI  A+  +H L  V+RD+KP+NILLD  GHI L DFG C K   
Sbjct: 191 -ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLC-KENI 248

Query: 233 DGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADS 292
           +    +    GTP+YL+PE+L           Y    DWW LG   YEM YG  PFY+ +
Sbjct: 249 EHNSTTSTFCGTPEYLAPEVLH-------KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN 301

Query: 293 TAETYGKIVHYKEHLSLPL-VDEGVPEEARDFIQRLLCPPETRLGRGGAGD----FRTHP 347
           TAE Y  I      L+ PL +   +   AR  ++ LL    T+  R GA D     ++H 
Sbjct: 302 TAEMYDNI------LNKPLQLKPNITNSARHLLEGLLQKDRTK--RLGAKDDFMEIKSHV 353

Query: 348 FFFGLDWDGL--RDSVPPFTPDFEGATDTCNFD--LVEDGLTAMVSGGGETL---SDIRE 400
           FF  ++WD L  +   PPF P+  G  D  +FD    E+ +   +    +++   + ++E
Sbjct: 354 FFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKE 413

Query: 401 GAPLGVHLPFVGYSYS 416
            A       F+G+SY+
Sbjct: 414 AAE-----AFLGFSYA 424


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  189 bits (479), Expect = 9e-48
 Identities = 132/376 (35%), Positives = 194/376 (51%), Gaps = 40/376 (10%)

Query: 58  SPTTPPAEPIVVRL---KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNK 114
           +P+ PP+    + L        +  DF  LKVIG+G+F +V + + K     YA+K++ K
Sbjct: 86  NPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQK 145

Query: 115 WDMLKRGEVSCFREERDVLV-NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKF 173
             +LK+ E      ER+VL+ N    ++  LHF+FQ  + LY V++Y  GG+L   L + 
Sbjct: 146 KAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR- 204

Query: 174 GERIPAE-MARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRA 232
            ER   E  ARFY AEI  A+  +H L  V+RD+KP+NILLD  GHI L DFG C K   
Sbjct: 205 -ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLC-KENI 262

Query: 233 DGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADS 292
           +    +    GTP+YL+PE+L           Y    DWW LG   YEM YG  PFY+ +
Sbjct: 263 EHNSTTSTFCGTPEYLAPEVLH-------KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN 315

Query: 293 TAETYGKIVHYKEHLSLPL-VDEGVPEEARDFIQRLLCPPETRLGRGGAGD----FRTHP 347
           TAE Y  I      L+ PL +   +   AR  ++ LL    T+  R GA D     ++H 
Sbjct: 316 TAEMYDNI------LNKPLQLKPNITNSARHLLEGLLQKDRTK--RLGAKDDFMEIKSHV 367

Query: 348 FFFGLDWDGL--RDSVPPFTPDFEGATDTCNFD--LVEDGLTAMVSGGGETL---SDIRE 400
           FF  ++WD L  +   PPF P+  G  D  +FD    E+ +   +    +++   + ++E
Sbjct: 368 FFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKE 427

Query: 401 GAPLGVHLPFVGYSYS 416
            A       F+G+SY+
Sbjct: 428 AAE-----AFLGFSYA 438


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  189 bits (479), Expect = 9e-48
 Identities = 132/376 (35%), Positives = 194/376 (51%), Gaps = 40/376 (10%)

Query: 58  SPTTPPAEPIVVRL---KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNK 114
           +P+ PP+    + L        +  DF  LKVIG+G+F +V + + K     YA+K++ K
Sbjct: 100 NPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQK 159

Query: 115 WDMLKRGEVSCFREERDVLV-NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKF 173
             +LK+ E      ER+VL+ N    ++  LHF+FQ  + LY V++Y  GG+L   L + 
Sbjct: 160 KAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQR- 218

Query: 174 GERIPAE-MARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRA 232
            ER   E  ARFY AEI  A+  +H L  V+RD+KP+NILLD  GHI L DFG C K   
Sbjct: 219 -ERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLC-KENI 276

Query: 233 DGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADS 292
           +    +    GTP+YL+PE+L           Y    DWW LG   YEM YG  PFY+ +
Sbjct: 277 EHNSTTSTFCGTPEYLAPEVLH-------KQPYDRTVDWWCLGAVLYEMLYGLPPFYSRN 329

Query: 293 TAETYGKIVHYKEHLSLPL-VDEGVPEEARDFIQRLLCPPETRLGRGGAGD----FRTHP 347
           TAE Y  I      L+ PL +   +   AR  ++ LL    T+  R GA D     ++H 
Sbjct: 330 TAEMYDNI------LNKPLQLKPNITNSARHLLEGLLQKDRTK--RLGAKDDFMEIKSHV 381

Query: 348 FFFGLDWDGL--RDSVPPFTPDFEGATDTCNFD--LVEDGLTAMVSGGGETL---SDIRE 400
           FF  ++WD L  +   PPF P+  G  D  +FD    E+ +   +    +++   + ++E
Sbjct: 382 FFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKE 441

Query: 401 GAPLGVHLPFVGYSYS 416
            A       F+G+SY+
Sbjct: 442 AAE-----AFLGFSYA 452


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,289,143
Number of Sequences: 37866
Number of extensions: 1496395
Number of successful extensions: 9912
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 674
Number of HSP's successfully gapped in prelim test: 416
Number of HSP's that attempted gapping in prelim test: 6754
Number of HSP's gapped (non-prelim): 2079
length of query: 639
length of database: 18,247,518
effective HSP length: 109
effective length of query: 530
effective length of database: 14,120,124
effective search space: 7483665720
effective search space used: 7483665720
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.