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Search of human proteins with 126091040
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
(625 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 1281 0.0
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 1096 0.0
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 1090 0.0
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 988 0.0
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 521 e-148
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 521 e-148
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 515 e-146
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 513 e-145
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 366 e-101
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 365 e-101
gi|32698688 citron [Homo sapiens] 335 1e-91
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 275 9e-74
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 274 2e-73
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 217 3e-56
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 215 9e-56
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 214 1e-55
gi|148727255 microtubule associated serine/threonine kinase fami... 211 1e-54
gi|28557781 protein kinase C, eta [Homo sapiens] 200 4e-51
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 197 2e-50
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 197 3e-50
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 197 3e-50
gi|4885563 protein kinase C, epsilon [Homo sapiens] 196 7e-50
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 196 7e-50
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 196 7e-50
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 195 9e-50
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 189 9e-48
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 189 9e-48
gi|5453976 protein kinase C, theta [Homo sapiens] 188 1e-47
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 187 2e-47
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 187 2e-47
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 1281 bits (3316), Expect = 0.0
Identities = 625/625 (100%), Positives = 625/625 (100%)
Query: 1 MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR
Sbjct: 1 MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
Query: 61 LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER
Sbjct: 61 LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
Query: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV
Sbjct: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
Query: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP
Sbjct: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP
Sbjct: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
Query: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360
LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG
Sbjct: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360
Query: 361 ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA 420
ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA
Sbjct: 361 ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA 420
Query: 421 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 480
EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL
Sbjct: 421 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 480
Query: 481 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD 540
SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD
Sbjct: 481 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD 540
Query: 541 PPSHMAPRPWLWASARWWGQAPCTAATCCSLPGSLGLAYRRRFPCSCSPLFCLVPPPWAA 600
PPSHMAPRPWLWASARWWGQAPCTAATCCSLPGSLGLAYRRRFPCSCSPLFCLVPPPWAA
Sbjct: 541 PPSHMAPRPWLWASARWWGQAPCTAATCCSLPGSLGLAYRRRFPCSCSPLFCLVPPPWAA 600
Query: 601 LGWWPTPANSPQSGAAQEPPALPEP 625
LGWWPTPANSPQSGAAQEPPALPEP
Sbjct: 601 LGWWPTPANSPQSGAAQEPPALPEP 625
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 1096 bits (2835), Expect = 0.0
Identities = 545/549 (99%), Positives = 546/549 (99%)
Query: 1 MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR
Sbjct: 1 MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
Query: 61 LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER
Sbjct: 61 LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
Query: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV
Sbjct: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
Query: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP
Sbjct: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP
Sbjct: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
Query: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360
LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG
Sbjct: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360
Query: 361 ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA 420
ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA
Sbjct: 361 ATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA 420
Query: 421 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 480
EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL
Sbjct: 421 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 480
Query: 481 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD 540
SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD
Sbjct: 481 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD 540
Query: 541 PPSHMAPRP 549
PPSH+ P
Sbjct: 541 PPSHLDGPP 549
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 1090 bits (2819), Expect = 0.0
Identities = 545/554 (98%), Positives = 546/554 (98%), Gaps = 5/554 (0%)
Query: 1 MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR
Sbjct: 1 MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
Query: 61 LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER
Sbjct: 61 LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
Query: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV
Sbjct: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
Query: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP
Sbjct: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP
Sbjct: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
Query: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360
LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG
Sbjct: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEG 360
Query: 361 ATDTCNFDLVEDGLTAM-----ETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP 415
ATDTCNFDLVEDGLTAM ETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP
Sbjct: 361 ATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTP 420
Query: 416 MELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVL 475
MELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVL
Sbjct: 421 MELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVL 480
Query: 476 TRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPS 535
TRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPS
Sbjct: 481 TRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPS 540
Query: 536 PRATDPPSHMAPRP 549
PRATDPPSH+ P
Sbjct: 541 PRATDPPSHLDGPP 554
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 988 bits (2553), Expect = 0.0
Identities = 492/501 (98%), Positives = 493/501 (98%), Gaps = 5/501 (0%)
Query: 54 AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 113
AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV
Sbjct: 64 AEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEV 123
Query: 114 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 173
SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR
Sbjct: 124 SCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMAR 183
Query: 174 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 233
FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG
Sbjct: 184 FYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVG 243
Query: 234 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 293
TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY
Sbjct: 244 TPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY 303
Query: 294 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP
Sbjct: 304 KEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 363
Query: 354 FTPDFEGATDTCNFDLVEDGLTAM-----ETLSDIREGAPLGVHLPFVGYSYSCMALRDS 408
FTPDFEGATDTCNFDLVEDGLTAM ETLSDIREGAPLGVHLPFVGYSYSCMALRDS
Sbjct: 364 FTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDS 423
Query: 409 EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE 468
EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE
Sbjct: 424 EVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQE 483
Query: 469 ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT 528
ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT
Sbjct: 484 ALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGAT 543
Query: 529 AVTGVPSPRATDPPSHMAPRP 549
AVTGVPSPRATDPPSH+ P
Sbjct: 544 AVTGVPSPRATDPPSHLDGPP 564
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 521 bits (1342), Expect = e-148
Identities = 279/551 (50%), Positives = 374/551 (67%), Gaps = 34/551 (6%)
Query: 1 MSAEVRLRRLQQLVLDPGF------LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWA 54
MS EVRLR+L+Q +LD +E LLD+L+ ++ E S L ++K + ++L+WA
Sbjct: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
Query: 55 EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 114
+P ++K++RL R+DFEILKVIGRGAF EVAVVK+K +V+AMKI+NKW+MLKR E +
Sbjct: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
Query: 115 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 174
CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MARF
Sbjct: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
Query: 175 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 234
YLAE+V+AIDSVH+L YVHRDIKPDNIL+D GHIRLADFGSCLKL DGTV+S VAVGT
Sbjct: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
Query: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
PDY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI+++K
Sbjct: 241 PDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298
Query: 295 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
E P V E A+D I+RL+C E RLG+ G DF+ HPFF G+DWD +R+ P+
Sbjct: 299 ERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPY 358
Query: 355 TPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY-SCMALRDSE---- 409
P+ TDT NFD+ +D L ET+ A G HLPFVG++Y S L D
Sbjct: 359 IPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRV 418
Query: 410 VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAEVTLREL 466
GPT ++L+ ++ L+ ++ + E + + E E++ E+ T++ L
Sbjct: 419 TAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQESTQTVQAL 472
Query: 467 QEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAHVRQL-- 515
Q + + LT ++L E+E +R T++ + QL EA A ++L+ RQ+
Sbjct: 473 QYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKA 532
Query: 516 -QERMELLQAE 525
+++++ LQ E
Sbjct: 533 YEKQIKTLQQE 543
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 521 bits (1342), Expect = e-148
Identities = 279/551 (50%), Positives = 374/551 (67%), Gaps = 34/551 (6%)
Query: 1 MSAEVRLRRLQQLVLDPGF------LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWA 54
MS EVRLR+L+Q +LD +E LLD+L+ ++ E S L ++K + ++L+WA
Sbjct: 1 MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWA 60
Query: 55 EPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS 114
+P ++K++RL R+DFEILKVIGRGAF EVAVVK+K +V+AMKI+NKW+MLKR E +
Sbjct: 61 KPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETA 120
Query: 115 CFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 174
CFREERDVLVNGD +WIT LH+AFQD+N LYLVM+YYVGGDLLTLLSKF +R+P +MARF
Sbjct: 121 CFREERDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARF 180
Query: 175 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 234
YLAE+V+AIDSVH+L YVHRDIKPDNIL+D GHIRLADFGSCLKL DGTV+S VAVGT
Sbjct: 181 YLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGT 240
Query: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
PDY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI+++K
Sbjct: 241 PDYISPEILQAM--EDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHK 298
Query: 295 EHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
E P V E A+D I+RL+C E RLG+ G DF+ HPFF G+DWD +R+ P+
Sbjct: 299 ERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPY 358
Query: 355 TPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY-SCMALRDSE---- 409
P+ TDT NFD+ +D L ET+ A G HLPFVG++Y S L D
Sbjct: 359 IPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRV 418
Query: 410 VPGPTPMELE--AEQLLEPHVQAPSLEPSVSP-QDETAEVAVPAAVPAAEAEAEVTLREL 466
GPT ++L+ ++ L+ ++ + E + + E E++ E+ T++ L
Sbjct: 419 TAGPTSLDLDVNVQRTLDNNLATEAYERRIKRLEQEKLELS------RKLQESTQTVQAL 472
Query: 467 QEALEEEVLTR------QSLSREMEAIR---TDNQNFASQLREAEARNRDLEAHVRQL-- 515
Q + + LT ++L E+E +R T++ + QL EA A ++L+ RQ+
Sbjct: 473 QYSTVDGPLTASKDLEIKNLKEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAFRQIKA 532
Query: 516 -QERMELLQAE 525
+++++ LQ E
Sbjct: 533 YEKQIKTLQQE 543
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 515 bits (1326), Expect = e-146
Identities = 278/561 (49%), Positives = 376/561 (67%), Gaps = 38/561 (6%)
Query: 1 MSAEVRLRRLQQLVLDPGF-----LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAE 55
MSA+VRL++L+QL+LD + L +E LLD+L+ ++ E S L +DKYVA+FL+WA+
Sbjct: 1 MSAKVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAK 60
Query: 56 PIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSC 115
P +KE++L R+DFEI+KVIGRGAF EVAVVKMK T ++YAMKI+NKW+MLKR E +C
Sbjct: 61 PFTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETAC 120
Query: 116 FREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFY 175
FREERDVLVNGD +WIT LH+AFQDEN+LYLVM+YYVGGDLLTLLSKF +++P +MARFY
Sbjct: 121 FREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFY 180
Query: 176 LAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTP 235
+ E+V+AIDS+H+L YVHRDIKPDN+LLD GHIRLADFGSCLK+ DGTV+S VAVGTP
Sbjct: 181 IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTP 240
Query: 236 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 295
DY+SPEILQA+ G G YGPECDWW+LGV YEM YG+TPFYA+S ETYGKI++++E
Sbjct: 241 DYISPEILQAM--EDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEE 298
Query: 296 HLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFT 355
P V EEA+D IQRL+C E RLG+ G DF+ H FF GL+W+ +R+ P+
Sbjct: 299 RFQFPSHVTDVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLNWENIRNLEAPYI 358
Query: 356 PDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSY---SCMA-------- 404
PD +DT NFD+ +D L E L G+HLPF+G+++ SC +
Sbjct: 359 PDVSSPSDTSNFDVDDDVLRNTEILPPGSHTGFSGLHLPFIGFTFTTESCFSDRGSLKSI 418
Query: 405 ------LRDSEVPGPT--PMELEAEQLLEPHVQAPSLEPSVSPQDETAEV----AVPAAV 452
+D +V +++EA + ++ LE S Q+ T V A+
Sbjct: 419 MQSNTLTKDEDVQRDLEHSLQMEAYERRIRRLEQEKLELSRKLQESTQTVQSLHGSSRAL 478
Query: 453 PAAEAEAEV-TLRELQEALEEEVLTRQSLSREME---AIRTDNQNFASQLREAEARNR-- 506
+ + E+ L E E L+ ++ L R++E A+R + ++ +LR E ++R
Sbjct: 479 SNSNRDKEIKKLNEEIERLKNKIADSNRLERQLEDTVALRQEREDSTQRLRGLEKQHRVV 538
Query: 507 --DLEAHVRQLQERMELLQAE 525
+ E +QL E E L+++
Sbjct: 539 RQEKEELHKQLVEASERLKSQ 559
Score = 45.4 bits (106), Expect = 2e-04
Identities = 26/76 (34%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 465 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQA 524
ELQ ALE E+ +Q + E+ ++ N S+L+++EA+NR+L + L+++ME
Sbjct: 878 ELQSALEAEIRAKQLVQEELRKVKDANLTLESKLKDSEAKNRELLEEMEILKKKME---- 933
Query: 525 EGATAVTGVPSPRATD 540
E A TG+ P D
Sbjct: 934 EKFRADTGLKLPDFQD 949
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 513 bits (1321), Expect = e-145
Identities = 281/575 (48%), Positives = 361/575 (62%), Gaps = 55/575 (9%)
Query: 4 EVRLRRLQQLVLDP--GFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRL 61
E RLR L+QL G GL+ LLDLLL +H EL + L +++ VA FL WA P V ++
Sbjct: 2 ERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKV 61
Query: 62 KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERD 121
KE+RLQRDDFEILKVIGRGAF EV VV+ + TGQ++AMK+++KW+MLKR E +CFREERD
Sbjct: 62 KELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERD 121
Query: 122 VLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 181
VLV GD RW+T LH+AFQDE YLYLVM+YY GGDLLTLLS+F +R+P E+A+FYLAE+V+
Sbjct: 122 VLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVL 181
Query: 182 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 241
AI S+H+LGYVHRD+KPDN+LLD GHIRLADFGSCL+L +G V S VAVGTPDY+SPE
Sbjct: 182 AIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPE 241
Query: 242 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 301
ILQA+ G G YGP+CDWW+LGV AYE+ +G+TPFYA+S ETYGKI+++++HL P
Sbjct: 242 ILQAM--EEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPP 299
Query: 302 VDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGA 361
VP A+D I++LLC E RLGRGG DFR HPFF G+DW+ L S P+ P+ G
Sbjct: 300 DVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGP 359
Query: 362 TDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSC------------------M 403
DT NFD+ +D L TL GA G HLPFVG++Y+ +
Sbjct: 360 MDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKL 419
Query: 404 ALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSP-QDETAEV-----------AVPAA 451
+ E + EA H + L V +D E+ PA
Sbjct: 420 QCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAG 479
Query: 452 VPAAEAEAEVTL----RELQE----------------ALEEEVLTRQSLSREME-AIRTD 490
P +++ L REL E +EE+L R ++E E A +
Sbjct: 480 SPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQ 539
Query: 491 NQNFASQLREAEARNRDLEAHVRQLQERMELLQAE 525
+ +SQL EA A R+LEA V L ++ LQ +
Sbjct: 540 TRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQ 574
Score = 33.5 bits (75), Expect = 0.60
Identities = 16/55 (29%), Positives = 30/55 (54%)
Query: 465 ELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERM 519
ELQ ALE E+ +Q L + ++ +L+EAE +++ L+ + L+E +
Sbjct: 744 ELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREEL 798
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 366 bits (940), Expect = e-101
Identities = 205/565 (36%), Positives = 323/565 (57%), Gaps = 44/565 (7%)
Query: 2 SAEVRLRRLQQLVLDP-GFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVR 60
S E R ++ L+ DP + + LLD L + +L L ++K + +FL + + +
Sbjct: 6 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINK 65
Query: 61 LKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREER 120
++++R++ +D+E++KVIGRGAF EV +V+ K T +VYAMK+++K++M+KR + + F EER
Sbjct: 66 IRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEER 125
Query: 121 DVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIV 180
D++ + W+ QL +AFQD+ YLY+VMEY GGDL+ L+S + +P + ARFY AE+V
Sbjct: 126 DIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVV 183
Query: 181 MAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
+A+D++H +G++HRD+KPDN+LLD+ GH++LADFG+C+K+ +G VR AVGTPDY+SP
Sbjct: 184 LALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISP 243
Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLP 300
E+L++ G G G YG ECDWW++GVF YEM G TPFYADS TY KI+++K L+ P
Sbjct: 244 EVLKSQG---GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP 300
Query: 301 LVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPDF 358
D + +EA++ I L E RLGR G + + H FF W+ LRD+V P PD
Sbjct: 301 -DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDL 359
Query: 359 EGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYS-YSCMALRDSEVPGPTPME 417
DT NFD +E+ ET + A +G LPFVG++ YS S P
Sbjct: 360 SSDIDTSNFDDLEEDKGEEETFPIPK--AFVGNQLPFVGFTYYSNRRYLSSANPNDNRTS 417
Query: 418 LEAEQLLEPHVQAP------------SLEPSVSPQDETAEVAVPAAVPAAEAEA------ 459
A++ L+ +Q L+ + + T+ + + + + E
Sbjct: 418 SNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNL 477
Query: 460 --------------EVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARN 505
+ + E Q E+E R+++ E+ ++ ++ + ++ N
Sbjct: 478 ESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLAN 537
Query: 506 RDLEAHVRQLQERMELLQAEGATAV 530
L +QL+E +LL+ E TAV
Sbjct: 538 EKLSQLQKQLEEANDLLRTESDTAV 562
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 365 bits (937), Expect = e-101
Identities = 202/525 (38%), Positives = 310/525 (59%), Gaps = 40/525 (7%)
Query: 6 RLRRLQQLVLDPGF-LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEV 64
R R+L+ L+ DP + +E LLD L + +L L ++K + +FL E IV +++ +
Sbjct: 26 RQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGL 85
Query: 65 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 124
+++ +D++++KVIGRGAF EV +V+ K + +VYAMK+++K++M+KR + + F EERD++
Sbjct: 86 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 145
Query: 125 NGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAID 184
+ W+ QL +AFQD+ YLY+VMEY GGDL+ L+S + +P + A+FY AE+V+A+D
Sbjct: 146 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALD 203
Query: 185 SVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQ 244
++H +G +HRD+KPDN+LLD+ GH++LADFG+C+K+ G V AVGTPDY+SPE+L+
Sbjct: 204 AIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLK 263
Query: 245 AVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDE 304
+ G G G YG ECDWW++GVF YEM G TPFYADS TY KI+ +K L P D
Sbjct: 264 SQG---GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFP-EDA 319
Query: 305 GVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFG--LDWDGLRDSVPPFTPDFEGAT 362
+ + A++ I L E RLGR G + R HPFF WD +R++ P P+
Sbjct: 320 EISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDI 379
Query: 363 DTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQ 422
D+ NFD +ED +ET + A +G LPF+G++Y E
Sbjct: 380 DSSNFDDIEDDKGDVETFPIPK--AFVGNQLPFIGFTY------------------YREN 419
Query: 423 LLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSR 482
LL +PS + S Q E E + L L+E L E+ ++ L +
Sbjct: 420 LLLS--DSPSCRETDSIQSRKNE---------ESQEIQKKLYTLEEHLSNEMQAKEELEQ 468
Query: 483 EMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGA 527
+ +++ T + A +L E + +E+ +RQL+ LLQ + A
Sbjct: 469 KCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA 513
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 335 bits (858), Expect = 1e-91
Identities = 193/513 (37%), Positives = 294/513 (57%), Gaps = 33/513 (6%)
Query: 20 LGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGR 79
L E +LD L + +E L + K+V++F++ + L+E++ DFE+ ++G
Sbjct: 46 LSREGILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGC 105
Query: 80 GAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQ 139
G F+EV VV+ K TG +YAMK+M K +L + +VS F EER++L WI QL +AFQ
Sbjct: 106 GHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQ 165
Query: 140 DENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPD 199
D+N+LYLVMEY GGDLL+LL+++ +++ + +FYLAE+++A+ SVH +GYVHRDIKP+
Sbjct: 166 DKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPE 225
Query: 200 NILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPEC 259
NIL+DR GHI+L DFGS K+ ++ V + + +GTPDY++PE+L V G G G+YG +C
Sbjct: 226 NILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVL-TVMNGDGKGTYGLDC 284
Query: 260 DWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLC 319
DWW++GV AYEM YG++PF ++A T+ I++++ L P D V + D IQ LLC
Sbjct: 285 DWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFP-DDPKVSSDFLDLIQSLLC 343
Query: 320 PPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMET 379
+ RL G HPFF +DW+ +R+S PPF P + DT NFD E +
Sbjct: 344 GQKERLKFEG---LCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSS 400
Query: 380 LSDIREGAPLGVHLPFVGYSYS----CMALRDSEVPG---PTPMELEAEQLLEPHVQAPS 432
+ G LPFVG+SYS + +S V G P ++LL +++
Sbjct: 401 PCQLSPSGFSGEELPFVGFSYSKALGILGRSESVVSGLDSPAKTSSMEKKLL---IKSKE 457
Query: 433 LEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQ 492
L+ S + + +E EA ++ +E++ E T++SL Q
Sbjct: 458 LQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASE---TQRSLL---------EQ 505
Query: 493 NFASQLREAEARNRDLEAHVRQLQERMELLQAE 525
+ A+ + E + R LE Q RME+ Q +
Sbjct: 506 DLATYITECSSLKRSLE------QARMEVSQED 532
Score = 32.7 bits (73), Expect = 1.0
Identities = 23/80 (28%), Positives = 37/80 (46%), Gaps = 3/80 (3%)
Query: 458 EAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQE 517
E E LRE+ EE+ L L R++ ++ Q SQL +A LE+ +RQ +
Sbjct: 853 ELETRLREVSLEHEEQKL---ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKT 909
Query: 518 RMELLQAEGATAVTGVPSPR 537
+E AE + + + R
Sbjct: 910 ELEETTAEAEEEIQALTAHR 929
Score = 31.6 bits (70), Expect = 2.3
Identities = 23/82 (28%), Positives = 38/82 (46%), Gaps = 5/82 (6%)
Query: 442 ETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIR---TDNQNFASQL 498
E E AV A+ A E + R+ +E E E+ Q+ E IR + + +
Sbjct: 643 EKLEKAVKASTEATELLQNI--RQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKH 700
Query: 499 REAEARNRDLEAHVRQLQERME 520
REA+ + LE H++Q ++ E
Sbjct: 701 REAQVSAQHLEVHLKQKEQHYE 722
Score = 30.8 bits (68), Expect = 3.9
Identities = 28/97 (28%), Positives = 41/97 (42%), Gaps = 5/97 (5%)
Query: 421 EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSL 480
EQ LE Q L+ S+ ++ A+ AA A E LR+ + LEE +
Sbjct: 867 EQKLELKRQLTELQLSLQERESQL-----TALQAARAALESQLRQAKTELEETTAEAEEE 921
Query: 481 SREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQE 517
+ + A R + Q LR + DLE + QL E
Sbjct: 922 IQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 958
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 275 bits (703), Expect = 9e-74
Identities = 141/344 (40%), Positives = 206/344 (59%), Gaps = 43/344 (12%)
Query: 59 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118
+RLK RL DDFE LKVIGRGAF EV +V+ K TG +YAMKI+ K DML++ +V+ R
Sbjct: 78 LRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRA 137
Query: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178
ERD+LV D W+ ++ ++FQD+ LYL+ME+ GGD++TLL K + + E +FY++E
Sbjct: 138 ERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYISE 196
Query: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222
V+AID++H+LG++HRDIKPDN+LLD GH++L+DFG C L+ +
Sbjct: 197 TVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPS 256
Query: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264
D + +++ VGTPDY++PE+ G Y CDWW+L
Sbjct: 257 DFSFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 309
Query: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324
GV YEM G PF +++ ETY K++++KE L P + + E+A+D I R E R
Sbjct: 310 GVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFP-PEVPISEKAKDLILRFCIDSENR 368
Query: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368
+G G + + HPFF G+DW+ +R+ + + DT NFD
Sbjct: 369 IGNSGVEEIKGHPFFEGVDWEHIRERPAAIPIEIKSIDDTSNFD 412
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 274 bits (701), Expect = 2e-73
Identities = 143/344 (41%), Positives = 208/344 (60%), Gaps = 43/344 (12%)
Query: 59 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 118
+RLK RL +DFE LKVIGRGAF EV +V+ K TG VYAMKI+ K DML++ +V R
Sbjct: 77 LRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRA 136
Query: 119 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 178
ERD+LV D W+ ++ ++FQD+ LYL+ME+ GGD++TLL K + + E +FY+AE
Sbjct: 137 ERDILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMK-KDTLTEEETQFYIAE 195
Query: 179 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLR----------------A 222
V+AIDS+H+LG++HRDIKPDN+LLD GH++L+DFG C L+ +
Sbjct: 196 TVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPS 255
Query: 223 DGTVRSL------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 264
D T +++ VGTPDY++PE+ G Y CDWW+L
Sbjct: 256 DFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG-------YNKLCDWWSL 308
Query: 265 GVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETR 324
GV YEM G PF +++ ETY K++++KE L+ P + + E+A+D I R C E R
Sbjct: 309 GVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP-PEVPISEKAKDLILRFCCEWEHR 367
Query: 325 LGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFD 368
+G G + +++ FF G+DW+ +R+ + + + DT NFD
Sbjct: 368 IGAPGVEEIKSNSFFEGVDWEHIRERPAAISIEIKSIDDTSNFD 411
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 217 bits (552), Expect = 3e-56
Identities = 120/314 (38%), Positives = 174/314 (55%), Gaps = 25/314 (7%)
Query: 70 DFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRR 129
DFE +K+I GA+ V +V+ + T Q +A+K +NK +++ R ++ ERD+L +
Sbjct: 366 DFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENP 425
Query: 130 WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRL 189
++ + +F+ +L +VMEY GGD TLL G +P +MAR Y AE V+A++ +H
Sbjct: 426 FVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGP-LPVDMARLYFAETVLALEYLHNY 484
Query: 190 GYVHRDIKPDNILLDRCGHIRLADFG-SCLKLRADGT----------VRSLV---AVGTP 235
G VHRD+KPDN+L+ GHI+L DFG S + L + T R + GTP
Sbjct: 485 GIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTP 544
Query: 236 DYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKE 295
+Y++PE++ G YG DWWA+GV YE G PF+ D+ E +G++V +
Sbjct: 545 EYIAPEVIFRQG-------YGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVV--SD 595
Query: 296 HLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 354
+ P DE +P +A+D I RLL P RLG GG + + HPFF LDW GL F
Sbjct: 596 EIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEF 655
Query: 355 TPDFEGATDTCNFD 368
P E DT FD
Sbjct: 656 VPQLEAEDDTSYFD 669
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 215 bits (548), Expect = 9e-56
Identities = 129/380 (33%), Positives = 192/380 (50%), Gaps = 36/380 (9%)
Query: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
+DFE +K+I GA+ V +V+ K T Q +AMK +NK +++ R ++ ERD+L +
Sbjct: 510 EDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 569
Query: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
++ + +F + +L +VMEY GGD TLL G +P +M R Y AE V+A++ +H
Sbjct: 570 PFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIG-ALPVDMVRLYFAETVLALEYLHN 628
Query: 189 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 234
G VHRD+KPDN+L+ GHI+L DFG + + + R + GT
Sbjct: 629 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGT 688
Query: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
P+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 689 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 739
Query: 295 EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
+ + P DE +P +A+D +LL P RLG G A + + HPFF GLDW GL
Sbjct: 740 DEIVWPEGDEALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAE 799
Query: 354 FTPDFEGATDTCNFDLVEDGLTAM--ETLSDIREGAPLGVH-----LPFVGYSYSCM--- 403
F P E DT FD + M E ++ E L + P YS M
Sbjct: 800 FIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERL 859
Query: 404 -ALRDSEVPGPTPMELEAEQ 422
L + P PT L E+
Sbjct: 860 SLLEERRTPPPTKRSLSEEK 879
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 214 bits (546), Expect = 1e-55
Identities = 157/510 (30%), Positives = 231/510 (45%), Gaps = 48/510 (9%)
Query: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
+DF+ +K+I GA+ V +V+ + T Q +AMK +NK +++ R ++ ERD+L +
Sbjct: 372 NDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAEN 431
Query: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
++ + +F+ +L +VMEY GGD TLL G +P EMAR Y AE V+A++ +H
Sbjct: 432 PFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGA-LPVEMARMYFAETVLALEYLHN 490
Query: 189 LGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AVGT 234
G VHRD+KPDN+L+ GHI+L DFG + + + R + GT
Sbjct: 491 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGT 550
Query: 235 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 294
P+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 551 PEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI--S 601
Query: 295 EHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPP 353
+ + P DE +P EA+ I LL P RLG GGA + + H FF LDW GL
Sbjct: 602 DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAE 661
Query: 354 FTPDFEGATDTCNFDLVEDGLTAMETL--SDIREGAPLGVH-----LPFVGYSYSCMALR 406
F P E DT FD D + + D E P+ + P YS M
Sbjct: 662 FIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQL 721
Query: 407 DSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLREL 466
P TP+ EP + P E V+ + E E+
Sbjct: 722 SQHEP-KTPVAAAGSSKREPSTKGP--EEKVAGKREGLGGLTLREKTWRGGSPEIKRFSA 778
Query: 467 QEA--LEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNR-----------DLEAHVR 513
EA LE E R A+ ++ A Q E EAR R L+A
Sbjct: 779 SEASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAP 838
Query: 514 QLQERMELLQAEGATAVTGVPSPRATDPPS 543
+ + + E + G + T P P PPS
Sbjct: 839 KEETQGEGTSSAGDSEATDRPRPGDLCPPS 868
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 211 bits (538), Expect = 1e-54
Identities = 116/328 (35%), Positives = 177/328 (53%), Gaps = 25/328 (7%)
Query: 67 QRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNG 126
+ DFE +K+I GA+ V V+ K++ Q +AMK +NK +++ R ++ ERD+L
Sbjct: 377 RESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDILTFA 436
Query: 127 DRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSV 186
+ ++ ++ +F+ +L +VMEY GGD TL+ G +P +MAR Y AE V+A++ +
Sbjct: 437 ENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGP-LPVDMARMYFAETVLALEYL 495
Query: 187 HRLGYVHRDIKPDNILLDRCGHIRLADFG-----------SCLKLRADGTVRSLV---AV 232
H G VHRD+KPDN+L+ GHI+L DFG + + + R +
Sbjct: 496 HNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVC 555
Query: 233 GTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVH 292
GTP+Y++PE++ G YG DWWA+G+ YE G PF+ D+ E +G+++
Sbjct: 556 GTPEYIAPEVILRQG-------YGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI- 607
Query: 293 YKEHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFFFGLDWDGLRDSV 351
+ ++ P DE P +A+D I LL P RLG GGA + + H FF LDW+ L
Sbjct: 608 -SDEINWPEKDEAPPPDAQDLITLLLRQNPLERLGTGGAYEVKQHRFFRSLDWNSLLRQK 666
Query: 352 PPFTPDFEGATDTCNFDLVEDGLTAMET 379
F P E DT FD + MET
Sbjct: 667 AEFIPQLESEDDTSYFDTRSEKYHHMET 694
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 200 bits (508), Expect = 4e-51
Identities = 125/339 (36%), Positives = 188/339 (55%), Gaps = 28/339 (8%)
Query: 65 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVL- 123
RL D+FE ++V+G+G+F +V + ++K+TG +YA+K++ K +L+ +V C E+ +L
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408
Query: 124 VNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 183
+ + ++TQL FQ + L+ VME+ GGDL+ + K R ARFY AEI+ A+
Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQK-SRRFDEARARFYAAEIISAL 467
Query: 184 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 243
+H G ++RD+K DN+LLD GH +LADFG C + +G V + GTPDY++PEIL
Sbjct: 468 MFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNG-VTTATFCGTPDYIAPEIL 526
Query: 244 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD 303
Q + YGP DWWA+GV YEM G PF A++ + + I++ + + P
Sbjct: 527 QEM-------LYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN--DEVVYP--- 574
Query: 304 EGVPEEARDFIQRLLCP-PETRLG---RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPD 357
+ E+A ++ + P RLG +GG HPFF +DW L R PPF P
Sbjct: 575 TWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPR 634
Query: 358 FEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFV 396
+ D NFD D + L+ I EG HLP +
Sbjct: 635 IKSREDVSNFD--PDFIKEEPVLTPIDEG-----HLPMI 666
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 197 bits (502), Expect = 2e-50
Identities = 130/360 (36%), Positives = 190/360 (52%), Gaps = 26/360 (7%)
Query: 56 PIVVRLKEVRLQRD--DFEILKVIGRGAFSEVAVVKMK---QTGQVYAMKIMNKWDMLKR 110
PI +KE + D FE+LKV+G+G+F +V +V+ K GQ+YAMK++ K + R
Sbjct: 56 PITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVR 115
Query: 111 GEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE 170
V + ERD+LV + +I +LH+AFQ E LYL++++ GGD+ T LSK E
Sbjct: 116 DRVRT-KMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSK-EVLFTEE 173
Query: 171 MARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLV 230
+FYLAE+ +A+D +H+LG V+RD+KP+NILLD GHI+L DFG K D ++
Sbjct: 174 DVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG-LSKESVDQEKKAYS 232
Query: 231 AVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI 290
GT +Y++PE++ G + DWW+ GV +EM G PF ET I
Sbjct: 233 FCGTVEYMAPEVVNRRG-------HSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMI 285
Query: 291 VHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDWDGL-- 347
+ K L +P + + EA+ ++ L P RLG G + + H FF +DWD L
Sbjct: 286 L--KAKLGMP---QFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYK 340
Query: 348 RDSVPPFTPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRD 407
R+ PPF P DT FD TA A H F G+S+ ++ +
Sbjct: 341 REVQPPFKPASGKPDDTFCFD---PEFTAKTPKDSPGLPASANAHQLFKGFSFVATSIAE 397
Score = 88.6 bits (218), Expect = 2e-17
Identities = 73/216 (33%), Positives = 106/216 (49%), Gaps = 27/216 (12%)
Query: 71 FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN-GDRR 129
+E+ + IG G++S T +A+KI++K KR EE ++L+ G
Sbjct: 426 YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDK---SKRDP----SEEIEILMRYGQHP 478
Query: 130 WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSK---FGERIPAEMARFYLAEIVMAIDSV 186
I L F D Y+YLV + GG+LL + K F ER +++ L I +D +
Sbjct: 479 NIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDI----LYVISKTVDYL 534
Query: 187 HRLGYVHRDIKPDNIL-LDRCGH---IRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEI 242
H G VHRD+KP NIL +D IR+ DFG +LR + + L T ++++PE+
Sbjct: 535 HCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLL-LTPCYTANFVAPEV 593
Query: 243 LQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPF 278
L G Y CD W+LGV Y M G TPF
Sbjct: 594 LMQQG-------YDAACDIWSLGVLFYTMLAGYTPF 622
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 197 bits (500), Expect = 3e-50
Identities = 125/352 (35%), Positives = 188/352 (53%), Gaps = 38/352 (10%)
Query: 31 GVHQELGASELAQDKYVADFLQ-WAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVK 89
G QE LA+ K DFL+ W P + D FE +K +G G+F V +VK
Sbjct: 10 GSEQESVKEFLAKAK--EDFLKKWESPA-----QNTAHLDQFERIKTLGTGSFGRVMLVK 62
Query: 90 MKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVME 149
K+TG YAMKI++K ++K ++ E+ +L + ++ +L F+F+D + LY+VME
Sbjct: 63 HKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVME 122
Query: 150 YYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHI 209
Y GG++ + L + G R ARFY A+IV+ + +H L ++RD+KP+N+L+D+ G+I
Sbjct: 123 YVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYI 181
Query: 210 RLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAY 269
++ DFG +++ R+ GTP+YL+PEI+ + G Y DWWALGV Y
Sbjct: 182 QVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG-------YNKAVDWWALGVLIY 230
Query: 270 EMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDEGVPEEARDFIQRLLCPPET-R 324
EM G PF+AD + Y KI V + H S + +D ++ LL T R
Sbjct: 231 EMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS---------SDLKDLLRNLLQVDLTKR 281
Query: 325 LG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGATDTCNFDLVED 372
G + G D + H +F DW + R PF P F+G DT NFD E+
Sbjct: 282 FGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEE 333
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 197 bits (500), Expect = 3e-50
Identities = 118/330 (35%), Positives = 178/330 (53%), Gaps = 28/330 (8%)
Query: 49 DFL-QWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDM 107
DFL +W P + D FE L+ +G G+F V +V+ ++TG YAMKI+NK +
Sbjct: 26 DFLYRWGNPA-----QNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKV 80
Query: 108 LKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERI 167
+K +V E+ +L D ++ +L F+F+D +YLYLVMEY GG++ + L + G R
Sbjct: 81 VKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVG-RF 139
Query: 168 PAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVR 227
A FY A++V+A+ +H L +HRD+KP+N+L+D+ G++++ DFG +++ R
Sbjct: 140 SEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKG----R 195
Query: 228 SLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETY 287
+ GTP+YL+PEI+ + G Y DWWALGV YEM G PFYAD + Y
Sbjct: 196 TWTLCGTPEYLAPEIILSKG-------YNKAVDWWALGVLIYEMAVGFPPFYADQPIQIY 248
Query: 288 GKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDW 344
KIV + L + + ++ LL T R G R G GD + H +F W
Sbjct: 249 EKIVSGRVRFPSKL-----SSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSW 303
Query: 345 DGLRDS--VPPFTPDFEGATDTCNFDLVED 372
+ + PF P + G D NFD E+
Sbjct: 304 IAIYEKKVEAPFIPKYTGPGDASNFDDYEE 333
>gi|4885563 protein kinase C, epsilon [Homo sapiens]
Length = 737
Score = 196 bits (497), Expect = 7e-50
Identities = 116/312 (37%), Positives = 176/312 (56%), Gaps = 22/312 (7%)
Query: 65 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 124
RL D+F +KV+G+G+F +V + ++K +VYA+K++ K +L+ +V C E+ +L
Sbjct: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461
Query: 125 NGDRR-WITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAI 183
+ ++TQL+ FQ ++ L+ VMEY GGDL+ + + + +RFY AE+ A+
Sbjct: 462 LARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQR-SRKFDEPRSRFYAAEVTSAL 520
Query: 184 DSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEIL 243
+H+ G ++RD+K DNILLD GH +LADFG C + +G V + GTPDY++PEIL
Sbjct: 521 MFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNG-VTTTTFCGTPDYIAPEIL 579
Query: 244 QAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVD 303
Q + YGP DWWALGV YEM GQ PF AD+ + + I+H + + P+
Sbjct: 580 QEL-------EYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILH--DDVLYPV-- 628
Query: 304 EGVPEEARDFIQRLLCP-PETRLG----RGGAGDFRTHPFFFGLDWDGLRDS--VPPFTP 356
+ +EA ++ + P RLG + G + HPFF +DW L PPF P
Sbjct: 629 -WLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKP 687
Query: 357 DFEGATDTCNFD 368
+ D NFD
Sbjct: 688 RIKTKRDVNNFD 699
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 196 bits (497), Expect = 7e-50
Identities = 114/313 (36%), Positives = 174/313 (55%), Gaps = 30/313 (9%)
Query: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
D FE +K +G G+F V +VK K+TG YAMKI++K ++K ++ E+ +L +
Sbjct: 34 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 93
Query: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
++ +L F+F+D + LY+VMEY GG++ + L + G R ARFY A+IV+ + +H
Sbjct: 94 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHS 152
Query: 189 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 248
L ++RD+KP+N+L+D+ G+I++ DFG +++ R+ GTP+YL+PEI+ + G
Sbjct: 153 LDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG- 207
Query: 249 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDE 304
Y DWWALGV YEM G PF+AD + Y KI V + H S
Sbjct: 208 ------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS------ 255
Query: 305 GVPEEARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFE 359
+ +D ++ LL T R G + G D + H +F DW + R PF P F+
Sbjct: 256 ---SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFK 312
Query: 360 GATDTCNFDLVED 372
G DT NFD E+
Sbjct: 313 GPGDTSNFDDYEE 325
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 196 bits (497), Expect = 7e-50
Identities = 121/342 (35%), Positives = 185/342 (54%), Gaps = 34/342 (9%)
Query: 44 DKYVADFLQWAEPIVVRLKEVRLQR----DDFEILKVIGRGAFSEVAVVKMKQTGQVYAM 99
D+ + +FL A+ ++ E Q +DFE K +G G+F V +VK K T Q YAM
Sbjct: 60 DRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAM 119
Query: 100 KIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTL 159
KI++K ++K ++ E+ +L + ++ +L +AF+D + LY+VMEY GG++ +
Sbjct: 120 KILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSH 179
Query: 160 LSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLK 219
L + G R ARFY A+IV+ + +H L ++RD+KP+N+L+D G+I++ DFG +
Sbjct: 180 LRRIG-RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKR 238
Query: 220 LRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFY 279
++ R+ GTP+YL+PEI+ + G Y DWWALGV YEM G PF+
Sbjct: 239 VKG----RTWTLCGTPEYLAPEIILSKG-------YNKAVDWWALGVLIYEMAAGYPPFF 287
Query: 280 ADSTAETYGKI----VHYKEHLSLPLVDEGVPEEARDFIQRLLCPPET-RLG--RGGAGD 332
AD + Y KI V + H S + +D ++ LL T R G + G D
Sbjct: 288 ADQPIQIYEKIVSGKVRFPSHFS---------SDLKDLLRNLLQVDLTKRFGNLKNGVSD 338
Query: 333 FRTHPFFFGLDWDGL--RDSVPPFTPDFEGATDTCNFDLVED 372
+TH +F DW + R PF P F G+ DT NFD E+
Sbjct: 339 IKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEE 380
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 195 bits (496), Expect = 9e-50
Identities = 115/313 (36%), Positives = 173/313 (55%), Gaps = 30/313 (9%)
Query: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDR 128
+DFE K +G G+F V +VK K T Q YAMKI++K ++K ++ E+ +L +
Sbjct: 42 EDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 101
Query: 129 RWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHR 188
++ +L +AF+D + LY+VMEY GG++ + L + G R ARFY A+IV+ + +H
Sbjct: 102 PFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIG-RFSEPHARFYAAQIVLTFEYLHS 160
Query: 189 LGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGG 248
L ++RD+KP+N+L+D G+I++ DFG +++ R+ GTP+YL+PEI+ + G
Sbjct: 161 LDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKG----RTWTLCGTPEYLAPEIILSKG- 215
Query: 249 GPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKI----VHYKEHLSLPLVDE 304
Y DWWALGV YEM G PF+AD + Y KI V + H S
Sbjct: 216 ------YNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFS------ 263
Query: 305 GVPEEARDFIQRLLCPPET-RLG--RGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFE 359
+ +D ++ LL T R G + G D +TH +F DW + R PF P F
Sbjct: 264 ---SDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFR 320
Query: 360 GATDTCNFDLVED 372
G+ DT NFD E+
Sbjct: 321 GSGDTSNFDDYEE 333
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 189 bits (479), Expect = 9e-48
Identities = 117/306 (38%), Positives = 170/306 (55%), Gaps = 23/306 (7%)
Query: 71 FEILKVIGRGAFSEVAVV---KMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 127
FE+LKV+G+G++ +V +V K GQ+YAMK++ K + R V + ERD+L +
Sbjct: 67 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILAEVN 125
Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVH 187
+I +LH+AFQ E LYL++++ GGDL T LSK E +FYLAE+ +A+D +H
Sbjct: 126 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 184
Query: 188 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 247
LG ++RD+KP+NILLD GHI++ DFG K D R+ GT +Y++PE++ G
Sbjct: 185 SLGIIYRDLKPENILLDEEGHIKITDFG-LSKEAIDHDKRAYSFCGTIEYMAPEVVNRRG 243
Query: 248 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVP 307
+ DWW+ GV +EM G PF ET I+ K L +P G
Sbjct: 244 -------HTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL--KAKLGMPQFLSG-- 292
Query: 308 EEARDFIQRLL-CPPETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGAT 362
EA+ ++ L P RLG G G + + HPFF +DW+ L ++ PPF P
Sbjct: 293 -EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPE 351
Query: 363 DTCNFD 368
DT +FD
Sbjct: 352 DTFHFD 357
Score = 100 bits (248), Expect = 5e-21
Identities = 99/302 (32%), Positives = 144/302 (47%), Gaps = 34/302 (11%)
Query: 38 ASELAQDKYVADFLQW-AEPIVVRLKEVRLQ-RDDFEILKVIGRGAFSEVAVVKMKQTGQ 95
AS L Q+ D + PIV +L + D +EI + IG G++S K T
Sbjct: 388 ASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDT 447
Query: 96 VYAMKIMNKWDMLKRGEVSCFREERDVLVN-GDRRWITQLHFAFQDENYLYLVMEYYVGG 154
YA+KI++K KR EE ++L+ G I L + D ++YLVME GG
Sbjct: 448 EYAVKIIDK---SKRDP----SEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG 500
Query: 155 DLLTLLSK---FGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILL-DRCG--- 207
+LL + + F ER +++ L I +D +H G VHRD+KP NIL D G
Sbjct: 501 ELLDRILRQRYFSEREASDV----LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPE 556
Query: 208 HIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVF 267
IR+ DFG +LRA G + T ++++PE+L+ G Y CD W+LG+
Sbjct: 557 SIRVCDFGFAKQLRA-GNGLLMTPCYTANFVAPEVLKRQG-------YDAACDIWSLGIL 608
Query: 268 AYEMFYGQTPFY---ADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPET 323
Y M G TPF D+ E +I K LS D + + A+D + ++L P
Sbjct: 609 LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWD-SISDAAKDVVSKMLHVDPHQ 667
Query: 324 RL 325
RL
Sbjct: 668 RL 669
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 189 bits (479), Expect = 9e-48
Identities = 117/306 (38%), Positives = 170/306 (55%), Gaps = 23/306 (7%)
Query: 71 FEILKVIGRGAFSEVAVV---KMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 127
FE+LKV+G+G++ +V +V K GQ+YAMK++ K + R V + ERD+L +
Sbjct: 59 FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILAEVN 117
Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVH 187
+I +LH+AFQ E LYL++++ GGDL T LSK E +FYLAE+ +A+D +H
Sbjct: 118 HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALALDHLH 176
Query: 188 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 247
LG ++RD+KP+NILLD GHI++ DFG K D R+ GT +Y++PE++ G
Sbjct: 177 SLGIIYRDLKPENILLDEEGHIKITDFG-LSKEAIDHDKRAYSFCGTIEYMAPEVVNRRG 235
Query: 248 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVP 307
+ DWW+ GV +EM G PF ET I+ K L +P G
Sbjct: 236 -------HTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL--KAKLGMPQFLSG-- 284
Query: 308 EEARDFIQRLL-CPPETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGAT 362
EA+ ++ L P RLG G G + + HPFF +DW+ L ++ PPF P
Sbjct: 285 -EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPE 343
Query: 363 DTCNFD 368
DT +FD
Sbjct: 344 DTFHFD 349
Score = 100 bits (248), Expect = 5e-21
Identities = 99/302 (32%), Positives = 144/302 (47%), Gaps = 34/302 (11%)
Query: 38 ASELAQDKYVADFLQW-AEPIVVRLKEVRLQ-RDDFEILKVIGRGAFSEVAVVKMKQTGQ 95
AS L Q+ D + PIV +L + D +EI + IG G++S K T
Sbjct: 380 ASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDT 439
Query: 96 VYAMKIMNKWDMLKRGEVSCFREERDVLVN-GDRRWITQLHFAFQDENYLYLVMEYYVGG 154
YA+KI++K KR EE ++L+ G I L + D ++YLVME GG
Sbjct: 440 EYAVKIIDK---SKRDP----SEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGG 492
Query: 155 DLLTLLSK---FGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILL-DRCG--- 207
+LL + + F ER +++ L I +D +H G VHRD+KP NIL D G
Sbjct: 493 ELLDRILRQRYFSEREASDV----LCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPE 548
Query: 208 HIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVF 267
IR+ DFG +LRA G + T ++++PE+L+ G Y CD W+LG+
Sbjct: 549 SIRVCDFGFAKQLRA-GNGLLMTPCYTANFVAPEVLKRQG-------YDAACDIWSLGIL 600
Query: 268 AYEMFYGQTPFY---ADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLL-CPPET 323
Y M G TPF D+ E +I K LS D + + A+D + ++L P
Sbjct: 601 LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWD-SISDAAKDVVSKMLHVDPHQ 659
Query: 324 RL 325
RL
Sbjct: 660 RL 661
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 188 bits (477), Expect = 1e-47
Identities = 110/310 (35%), Positives = 169/310 (54%), Gaps = 20/310 (6%)
Query: 63 EVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDV 122
+++L+ +DF + K++G+G+F +V + + K+T Q +A+K + K +L +V C E+ V
Sbjct: 372 QIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRV 431
Query: 123 L-VNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 181
L + + ++T + FQ + L+ VMEY GGDL+ + + A FY AEI++
Sbjct: 432 LSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSC-HKFDLSRATFYAAEIIL 490
Query: 182 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPE 241
+ +H G V+RD+K DNILLD+ GHI++ADFG C K G ++ GTPDY++PE
Sbjct: 491 GLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMC-KENMLGDAKTNTFCGTPDYIAPE 549
Query: 242 ILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPL 301
IL Y DWW+ GV YEM GQ+PF+ E + I + P
Sbjct: 550 ILLG-------QKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI-----RMDNPF 597
Query: 302 VDEGVPEEARDFIQRLLC-PPETRLGRGGAGDFRTHPFFFGLDWDGL--RDSVPPFTPDF 358
+ +EA+D + +L PE RL G GD R HP F ++W+ L ++ PPF P
Sbjct: 598 YPRWLEKEAKDLLVKLFVREPEKRL--GVRGDIRQHPLFREINWEELERKEIDPPFRPKV 655
Query: 359 EGATDTCNFD 368
+ D NFD
Sbjct: 656 KSPFDCSNFD 665
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 187 bits (475), Expect = 2e-47
Identities = 122/349 (34%), Positives = 185/349 (53%), Gaps = 30/349 (8%)
Query: 71 FEILKVIGRGAFSEVAVVKM---KQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 127
FE+LKV+G+G+F +V +V+ +G +YAMK++ K + R V + ERD+L + +
Sbjct: 71 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRT-KMERDILADVN 129
Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVH 187
++ +LH+AFQ E LYL++++ GGDL T LSK E +FYLAE+ + +D +H
Sbjct: 130 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALGLDHLH 188
Query: 188 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 247
LG ++RD+KP+NILLD GHI+L DFG K D ++ GT +Y++PE++ G
Sbjct: 189 SLGIIYRDLKPENILLDEEGHIKLTDFG-LSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 247
Query: 248 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVP 307
+ DWW+ GV +EM G PF ET I+ K L +P + +
Sbjct: 248 -------HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL--KAKLGMP---QFLS 295
Query: 308 EEARDFIQRLL-CPPETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGAT 362
EA+ ++ L P RLG G GA + + H F+ +DW+ L R+ PPF P
Sbjct: 296 TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPD 355
Query: 363 DTCNFDLVEDGLTAMETLSDIREGAP--LGVHLPFVGYSYSCMALRDSE 409
DT FD T ++ G P G H F G+S+ L + +
Sbjct: 356 DTFYFDTEFTSRTPKDS-----PGIPPSAGAHQLFRGFSFVATGLMEDD 399
Score = 98.6 bits (244), Expect = 2e-20
Identities = 87/269 (32%), Positives = 133/269 (49%), Gaps = 32/269 (11%)
Query: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN-GD 127
D + + + IG G++SE K T YA+K+++K KR EE ++L+ G
Sbjct: 425 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK---SKRDP----SEEIEILLRYGQ 477
Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSK---FGERIPAEMARFYLAEIVMAID 184
I L + D ++YLV E GG+LL + + F ER A F L I ++
Sbjct: 478 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSER----EASFVLHTIGKTVE 533
Query: 185 SVHRLGYVHRDIKPDNIL-LDRCGH---IRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
+H G VHRD+KP NIL +D G+ +R+ DFG +LRA+ + + T ++++P
Sbjct: 534 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGL-LMTPCYTANFVAP 592
Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFY---ADSTAETYGKIVHYKEHL 297
E+L+ G Y CD W+LG+ Y M G TPF +D+ E +I K L
Sbjct: 593 EVLKRQG-------YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 645
Query: 298 SLPLVDEGVPEEARDFIQRLL-CPPETRL 325
S + V E A+D + ++L P RL
Sbjct: 646 SGGNWNT-VSETAKDLVSKMLHVDPHQRL 673
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 187 bits (475), Expect = 2e-47
Identities = 122/349 (34%), Positives = 185/349 (53%), Gaps = 30/349 (8%)
Query: 71 FEILKVIGRGAFSEVAVVKM---KQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGD 127
FE+LKV+G+G+F +V +V+ +G +YAMK++ K + R V + ERD+L + +
Sbjct: 62 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRT-KMERDILADVN 120
Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVH 187
++ +LH+AFQ E LYL++++ GGDL T LSK E +FYLAE+ + +D +H
Sbjct: 121 HPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK-EVMFTEEDVKFYLAELALGLDHLH 179
Query: 188 RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVG 247
LG ++RD+KP+NILLD GHI+L DFG K D ++ GT +Y++PE++ G
Sbjct: 180 SLGIIYRDLKPENILLDEEGHIKLTDFG-LSKEAIDHEKKAYSFCGTVEYMAPEVVNRQG 238
Query: 248 GGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVP 307
+ DWW+ GV +EM G PF ET I+ K L +P + +
Sbjct: 239 -------HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL--KAKLGMP---QFLS 286
Query: 308 EEARDFIQRLL-CPPETRLGRG--GAGDFRTHPFFFGLDWDGL--RDSVPPFTPDFEGAT 362
EA+ ++ L P RLG G GA + + H F+ +DW+ L R+ PPF P
Sbjct: 287 TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPD 346
Query: 363 DTCNFDLVEDGLTAMETLSDIREGAP--LGVHLPFVGYSYSCMALRDSE 409
DT FD T ++ G P G H F G+S+ L + +
Sbjct: 347 DTFYFDTEFTSRTPKDS-----PGIPPSAGAHQLFRGFSFVATGLMEDD 390
Score = 98.6 bits (244), Expect = 2e-20
Identities = 87/269 (32%), Positives = 133/269 (49%), Gaps = 32/269 (11%)
Query: 69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVN-GD 127
D + + + IG G++SE K T YA+K+++K KR EE ++L+ G
Sbjct: 416 DGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDK---SKRDP----SEEIEILLRYGQ 468
Query: 128 RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSK---FGERIPAEMARFYLAEIVMAID 184
I L + D ++YLV E GG+LL + + F ER A F L I ++
Sbjct: 469 HPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSER----EASFVLHTIGKTVE 524
Query: 185 SVHRLGYVHRDIKPDNIL-LDRCGH---IRLADFGSCLKLRADGTVRSLVAVGTPDYLSP 240
+H G VHRD+KP NIL +D G+ +R+ DFG +LRA+ + + T ++++P
Sbjct: 525 YLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGL-LMTPCYTANFVAP 583
Query: 241 EILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFY---ADSTAETYGKIVHYKEHL 297
E+L+ G Y CD W+LG+ Y M G TPF +D+ E +I K L
Sbjct: 584 EVLKRQG-------YDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTL 636
Query: 298 SLPLVDEGVPEEARDFIQRLL-CPPETRL 325
S + V E A+D + ++L P RL
Sbjct: 637 SGGNWNT-VSETAKDLVSKMLHVDPHQRL 664
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,308,822
Number of Sequences: 37866
Number of extensions: 1455757
Number of successful extensions: 10172
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 673
Number of HSP's successfully gapped in prelim test: 419
Number of HSP's that attempted gapping in prelim test: 6959
Number of HSP's gapped (non-prelim): 2143
length of query: 625
length of database: 18,247,518
effective HSP length: 108
effective length of query: 517
effective length of database: 14,157,990
effective search space: 7319680830
effective search space used: 7319680830
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.