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Search of human proteins with 41872374
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41872374 polo-like kinase 3 [Homo sapiens]
(646 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41872374 polo-like kinase 3 [Homo sapiens] 1311 0.0
gi|93004081 polo-like kinase 2 [Homo sapiens] 625 e-179
gi|21359873 polo-like kinase 1 [Homo sapiens] 456 e-128
gi|121114283 polo-like kinase 4 [Homo sapiens] 228 1e-59
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 163 5e-40
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 162 7e-40
gi|62865643 aurora kinase C isoform 3 [Homo sapiens] 162 1e-39
gi|62865641 aurora kinase C isoform 2 [Homo sapiens] 162 1e-39
gi|62865639 aurora kinase C isoform 1 [Homo sapiens] 162 1e-39
gi|83776600 aurora kinase B [Homo sapiens] 160 3e-39
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 160 4e-39
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 160 4e-39
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens] 160 4e-39
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens] 160 4e-39
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens] 160 4e-39
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens] 160 4e-39
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 159 1e-38
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 152 9e-37
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 151 2e-36
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 151 2e-36
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 151 2e-36
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 151 2e-36
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 149 6e-36
gi|23943882 serine/threonine kinase 33 [Homo sapiens] 149 6e-36
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 149 8e-36
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 149 8e-36
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 149 8e-36
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 149 8e-36
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 149 8e-36
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 149 8e-36
>gi|41872374 polo-like kinase 3 [Homo sapiens]
Length = 646
Score = 1311 bits (3393), Expect = 0.0
Identities = 646/646 (100%), Positives = 646/646 (100%)
Query: 1 MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR 60
MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR
Sbjct: 1 MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGR 60
Query: 61 TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR 120
TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR
Sbjct: 61 TYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHR 120
Query: 121 HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG 180
HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG
Sbjct: 121 HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG 180
Query: 181 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE 240
ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE
Sbjct: 181 ILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPE 240
Query: 241 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR 300
ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR
Sbjct: 241 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR 300
Query: 301 DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN 360
DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN
Sbjct: 301 DRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKN 360
Query: 361 HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG 420
HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG
Sbjct: 361 HAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDG 420
Query: 421 FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL 480
FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL
Sbjct: 421 FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQL 480
Query: 481 SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME 540
SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME
Sbjct: 481 SSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYME 540
Query: 541 QHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEP 600
QHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEP
Sbjct: 541 QHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEP 600
Query: 601 LLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA 646
LLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
Sbjct: 601 LLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA 646
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 625 bits (1611), Expect = e-179
Identities = 327/650 (50%), Positives = 426/650 (65%), Gaps = 28/650 (4%)
Query: 20 PAPPAGPGPPPSALRGPELEMLAGLPTSDPG----RLITDPRSGRTYLKGRLLGKGGFAR 75
P PP PP S + P S G R+I DP +G+ Y +G++LGKGGFA+
Sbjct: 36 PQPPEESQPPQSQAQVPPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAK 95
Query: 76 CYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNI 135
CYE TD YA K+IP SRVAKPHQREKI EIELHR L H+H+V+F H+FED +NI
Sbjct: 96 CYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENI 155
Query: 136 YIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITE 195
YI LE CSR+S+AHI KAR L EPEVRYYLRQI+SGLKYLH++ ILHRDLKLGNFFI E
Sbjct: 156 YILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINE 215
Query: 196 NMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLC 255
MELKVGDFGLAARLEP E R++TICGTPNY++PEVL +QGHG E+D+W+LGCVMYT+L
Sbjct: 216 AMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLL 275
Query: 256 GSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFT 315
G PPFET +LKETYRCI++ YT+P+SL PA+ L+A++L +P DRPS+D I+RHDFF
Sbjct: 276 GRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFL 335
Query: 316 KGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNH-------AQERDEV 368
+G+TPDRL S C TVPD +PA++ F K +LFG KK + ++E +++
Sbjct: 336 QGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDI 395
Query: 369 SGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVET---APEDSSP---------RGTLAS 416
L L +TS+ Q ++ P ++ + A E+ RGTL S
Sbjct: 396 YKLRHDLKKTSITQQPSKHRTDEELQPPTTTVARSGTPAVENKQQIGDAIRMIVRGTLGS 455
Query: 417 SGDGFE--EGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKF 474
E E T+ +V ++ LR C+ MP A+ P WV+KWVDYSNK+
Sbjct: 456 CSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTS-FQWVTKWVDYSNKY 514
Query: 475 GFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRY 534
GFGYQLS V VLFN+G HM+L ++KTVHY + F P Q+ +L+Y
Sbjct: 515 GFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKY 574
Query: 535 FASYMEQHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLI 594
F+ YME++LM GGDLPSV ++ P LLQW+K+D+AL+MLF+DGT QVNFY DHTK+I
Sbjct: 575 FSHYMEENLMDGGDLPSVTDIRRPR-LYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKII 633
Query: 595 L-SGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDR 643
+ S E L+T++ +R + T+ + L GCS +L+ R+ YAL +L R
Sbjct: 634 ICSQNEEYLLTYINEDRISTTFRLTTLLMSGCSSELKNRMEYALNMLLQR 683
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 456 bits (1172), Expect = e-128
Identities = 259/637 (40%), Positives = 359/637 (56%), Gaps = 57/637 (8%)
Query: 15 RAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGRTYLKGRLLGKGGFA 74
+ A APA P G P A G A P + ++ DPRS R Y++GR LGKGGFA
Sbjct: 9 KLARAPADPGKAGVPGVAAPGAPA---AAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFA 65
Query: 75 RCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADN 134
+C+E +D +T +A K++P+S + KPHQREK+ EI +HR L H+H+V F FED D
Sbjct: 66 KCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDF 125
Query: 135 IYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT 194
+++ LELC R+SL + K R L EPE RYYLRQI+ G +YLH+ ++HRDLKLGN F+
Sbjct: 126 VFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN 185
Query: 195 ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLL 254
E++E+K+GDFGLA ++E +RKKT+CGTPNY+APEVL ++GH E DVWS+GC+MYTLL
Sbjct: 186 EDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLL 245
Query: 255 CGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFF 314
G PPFET+ LKETY IK+ Y++P ++ A L+ +L+ P RP+I+++L +FF
Sbjct: 246 VGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFF 305
Query: 315 TKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNHAQERDEVSGLVSG 374
T GY P RLPI +C+T+P P+ SL K L K +N ER
Sbjct: 306 TSGYIPARLPI-TCLTIPPRFSIAPS-SLDPSNRKPLTVLNKGLENPLPERPR------- 356
Query: 375 LMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESA 434
E P V V+ D + ++ E GL E
Sbjct: 357 -----------EKEEPVVRETGEV--VDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDP 403
Query: 435 LCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTH 494
C P+ WVSKWVDYS+K+G GYQL V VLFND T
Sbjct: 404 ACI----------------------PIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTR 441
Query: 495 MALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYMEQHLMK-GGDLPSVE 553
+ L + ++ Y +V + P +L ++ +L+YF +YM +HL+K G ++ E
Sbjct: 442 LILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPRE 501
Query: 554 EVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLL--VTFVARNRS 611
E+ P L W +T A+++ S+G+VQ+NF+ DHTKLIL PL+ VT++ R
Sbjct: 502 GDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILC---PLMAAVTYIDEKRD 558
Query: 612 ACTYLASHLRQLGCSPDLRQRLRYAL----RLLRDRS 644
TY S L + GC +L RLRYA +LL RS
Sbjct: 559 FRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRS 595
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 228 bits (582), Expect = 1e-59
Identities = 106/253 (41%), Positives = 159/253 (62%), Gaps = 1/253 (0%)
Query: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
G LLGKG FA Y A TG A+K+I + + K +++ NE+++H L+H I+
Sbjct: 15 GNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILE 74
Query: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKAR-HTLLEPEVRYYLRQILSGLKYLHQRGILH 183
++FED++ +Y+ LE+C + K R E E R+++ QI++G+ YLH GILH
Sbjct: 75 LYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILH 134
Query: 184 RDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADV 243
RDL L N +T NM +K+ DFGLA +L+ P ++ T+CGTPNY++PE+ R HG E+DV
Sbjct: 135 RDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDV 194
Query: 244 WSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRP 303
WSLGC+ YTLL G PPF+T +K T + Y +P+ LS+ A+ L+ +LR +P DR
Sbjct: 195 WSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRL 254
Query: 304 SIDQILRHDFFTK 316
S+ +L H F ++
Sbjct: 255 SLSSVLDHPFMSR 267
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 163 bits (412), Expect = 5e-40
Identities = 107/333 (32%), Positives = 172/333 (51%), Gaps = 16/333 (4%)
Query: 20 PAPPAGPGP------PPSALRGPELEM-LAGLPTSDPGRLITDPRSGRTYLKGRLLGKGG 72
PA P G G P +A G L ++G+P R G + R LG+G
Sbjct: 13 PAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGNYLIGSRKLGEGS 72
Query: 73 FARCYEATDTETGSAYAVKVIPQSRVAKP-HQREKILNEIELHRDLQHRHIVRFSHHFED 131
FA+ E TG A+KVI + R K + + + E ++ + ++H +I + E
Sbjct: 73 FAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILET 132
Query: 132 ADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNF 191
++ Y+ +ELC +L H + L E E R Y+RQ++S +++LH+ G++HRDLK+ N
Sbjct: 133 ENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENL 192
Query: 192 FITENMELKVGDFGLA--ARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCV 249
+ E+ +K+ DFGL+ A + T CG+P Y APE+L R+ +GP+ DVWS+G
Sbjct: 193 LLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVN 252
Query: 250 MYTLLCGSPPF--ETADLKETY-RCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSID 306
MY +L G+ PF E L+ Y + + + LP LS A L ++L P RP+I
Sbjct: 253 MYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQ 312
Query: 307 QILRHDFFTKGYT---PDRLPISSCVTVPDLTP 336
Q L + + + YT P + + +++ DL+P
Sbjct: 313 QALANRWLNENYTGKVPCNVTYPNRISLEDLSP 345
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 162 bits (411), Expect = 7e-40
Identities = 125/410 (30%), Positives = 186/410 (45%), Gaps = 49/410 (11%)
Query: 68 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSH 127
LGKG + + AT+ +G A+K I + ++ I EIE+ L H HI+
Sbjct: 61 LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE 120
Query: 128 HFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLK 187
FE+ D I I +E S+ L R L E E R++ RQI+S + Y H+ G++HRDLK
Sbjct: 121 VFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLK 180
Query: 188 LGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWSL 246
L N + +N +K+ DFGL + L ++ +T CG+P Y +PE++ R GPE D W+L
Sbjct: 181 LENILLDDNCNIKIADFGL-SNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWAL 239
Query: 247 GCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSID 306
G ++YTL+ G+ PF+ D K R I Y P S AR L+ +L +P R +I+
Sbjct: 240 GVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRATIE 298
Query: 307 QILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSL-------------------FAKV 347
I H + GY + + C + D P AR + AK
Sbjct: 299 DIANHWWVNWGY---KSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKP 355
Query: 348 TKS--LFGRKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPEAPA-ASGPAPVSLVETA 404
T S + R++ K +E D SG QDA PE+P+ S P +++
Sbjct: 356 TTSEVMLERQRSLKKSKKENDFAQ---SG--------QDAVPESPSKLSSKRPKGILKKR 404
Query: 405 PEDSSPRGTLASSGDGFEEGLTVATV-----VESALCALRNCIAFMPPAE 449
S GF EG+ + +E LC + P AE
Sbjct: 405 SNSEH-----RSHSTGFIEGVVGPALPSTFKMEQDLCRTGVLLPSSPEAE 449
>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
Length = 275
Score = 162 bits (409), Expect = 1e-39
Identities = 88/247 (35%), Positives = 137/247 (55%), Gaps = 2/247 (0%)
Query: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
GR LGKG F Y A E+ A+KV+ +S++ K ++ EIE+ LQH +I+R
Sbjct: 12 GRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILR 71
Query: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHR 184
++F DA +Y+ LE R L + L E + ++ L Y H + ++HR
Sbjct: 72 LYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHR 131
Query: 185 DLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVW 244
D+K N + E+K+ DFG + + P R+KT+CGT +Y+ PE++ + + + D+W
Sbjct: 132 DIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLW 189
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
+G + Y LL G PPFE+A ETYR I +V P S+ L AR L++ +LR P +R
Sbjct: 190 CIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLP 249
Query: 305 IDQILRH 311
+ QIL+H
Sbjct: 250 LAQILKH 256
>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
Length = 290
Score = 162 bits (409), Expect = 1e-39
Identities = 88/247 (35%), Positives = 137/247 (55%), Gaps = 2/247 (0%)
Query: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
GR LGKG F Y A E+ A+KV+ +S++ K ++ EIE+ LQH +I+R
Sbjct: 27 GRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILR 86
Query: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHR 184
++F DA +Y+ LE R L + L E + ++ L Y H + ++HR
Sbjct: 87 LYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHR 146
Query: 185 DLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVW 244
D+K N + E+K+ DFG + + P R+KT+CGT +Y+ PE++ + + + D+W
Sbjct: 147 DIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLW 204
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
+G + Y LL G PPFE+A ETYR I +V P S+ L AR L++ +LR P +R
Sbjct: 205 CIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLP 264
Query: 305 IDQILRH 311
+ QIL+H
Sbjct: 265 LAQILKH 271
>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
Length = 309
Score = 162 bits (409), Expect = 1e-39
Identities = 88/247 (35%), Positives = 137/247 (55%), Gaps = 2/247 (0%)
Query: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
GR LGKG F Y A E+ A+KV+ +S++ K ++ EIE+ LQH +I+R
Sbjct: 46 GRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILR 105
Query: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHR 184
++F DA +Y+ LE R L + L E + ++ L Y H + ++HR
Sbjct: 106 LYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHR 165
Query: 185 DLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVW 244
D+K N + E+K+ DFG + + P R+KT+CGT +Y+ PE++ + + + D+W
Sbjct: 166 DIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLW 223
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
+G + Y LL G PPFE+A ETYR I +V P S+ L AR L++ +LR P +R
Sbjct: 224 CIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLP 283
Query: 305 IDQILRH 311
+ QIL+H
Sbjct: 284 LAQILKH 290
>gi|83776600 aurora kinase B [Homo sapiens]
Length = 344
Score = 160 bits (406), Expect = 3e-39
Identities = 91/278 (32%), Positives = 148/278 (53%), Gaps = 13/278 (4%)
Query: 45 PTSDPGRLITDPRSGRTYLK-----------GRLLGKGGFARCYEATDTETGSAYAVKVI 93
PT+ PG+ + + SG + GR LGKG F Y A + ++ A+KV+
Sbjct: 49 PTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVL 108
Query: 94 PQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKA 153
+S++ K ++ EIE+ L H +I+R ++F D IY+ LE R L +
Sbjct: 109 FKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQK 168
Query: 154 RHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPP 213
T E + ++ L Y H + ++HRD+K N + ELK+ DFG + + P
Sbjct: 169 SCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWS--VHAP 226
Query: 214 EQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIK 273
R+KT+CGT +Y+ PE++ + H + D+W +G + Y LL G+PPFE+A ETYR I
Sbjct: 227 SLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIV 286
Query: 274 QVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRH 311
+V PAS+ + A+ L++ +LR +P +R + Q+ H
Sbjct: 287 KVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAH 324
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 160 bits (404), Expect = 4e-39
Identities = 80/251 (31%), Positives = 139/251 (55%), Gaps = 2/251 (0%)
Query: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
GR LGKG F Y A + ++ A+KV+ ++++ K ++ E+E+ L+H +I+R
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHR 184
+F DA +Y+ LE ++ + E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 185 DLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVW 244
D+K N + ELK+ DFG + + P R+ T+CGT +Y+ PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG + Y L G PPFE +ETY+ I +V +T P ++ AR L++ +L+ +P RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 305 IDQILRHDFFT 315
+ ++L H + T
Sbjct: 374 LREVLEHPWIT 384
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 160 bits (404), Expect = 4e-39
Identities = 80/251 (31%), Positives = 139/251 (55%), Gaps = 2/251 (0%)
Query: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
GR LGKG F Y A + ++ A+KV+ ++++ K ++ E+E+ L+H +I+R
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHR 184
+F DA +Y+ LE ++ + E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 185 DLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVW 244
D+K N + ELK+ DFG + + P R+ T+CGT +Y+ PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG + Y L G PPFE +ETY+ I +V +T P ++ AR L++ +L+ +P RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 305 IDQILRHDFFT 315
+ ++L H + T
Sbjct: 374 LREVLEHPWIT 384
>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 160 bits (404), Expect = 4e-39
Identities = 80/251 (31%), Positives = 139/251 (55%), Gaps = 2/251 (0%)
Query: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
GR LGKG F Y A + ++ A+KV+ ++++ K ++ E+E+ L+H +I+R
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHR 184
+F DA +Y+ LE ++ + E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 185 DLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVW 244
D+K N + ELK+ DFG + + P R+ T+CGT +Y+ PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG + Y L G PPFE +ETY+ I +V +T P ++ AR L++ +L+ +P RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 305 IDQILRHDFFT 315
+ ++L H + T
Sbjct: 374 LREVLEHPWIT 384
>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 160 bits (404), Expect = 4e-39
Identities = 80/251 (31%), Positives = 139/251 (55%), Gaps = 2/251 (0%)
Query: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
GR LGKG F Y A + ++ A+KV+ ++++ K ++ E+E+ L+H +I+R
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHR 184
+F DA +Y+ LE ++ + E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 185 DLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVW 244
D+K N + ELK+ DFG + + P R+ T+CGT +Y+ PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG + Y L G PPFE +ETY+ I +V +T P ++ AR L++ +L+ +P RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 305 IDQILRHDFFT 315
+ ++L H + T
Sbjct: 374 LREVLEHPWIT 384
>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 160 bits (404), Expect = 4e-39
Identities = 80/251 (31%), Positives = 139/251 (55%), Gaps = 2/251 (0%)
Query: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
GR LGKG F Y A + ++ A+KV+ ++++ K ++ E+E+ L+H +I+R
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHR 184
+F DA +Y+ LE ++ + E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 185 DLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVW 244
D+K N + ELK+ DFG + + P R+ T+CGT +Y+ PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG + Y L G PPFE +ETY+ I +V +T P ++ AR L++ +L+ +P RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 305 IDQILRHDFFT 315
+ ++L H + T
Sbjct: 374 LREVLEHPWIT 384
>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 160 bits (404), Expect = 4e-39
Identities = 80/251 (31%), Positives = 139/251 (55%), Gaps = 2/251 (0%)
Query: 65 GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVR 124
GR LGKG F Y A + ++ A+KV+ ++++ K ++ E+E+ L+H +I+R
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILR 195
Query: 125 FSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHR 184
+F DA +Y+ LE ++ + E Y+ ++ + L Y H + ++HR
Sbjct: 196 LYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHR 255
Query: 185 DLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVW 244
D+K N + ELK+ DFG + + P R+ T+CGT +Y+ PE++ + H + D+W
Sbjct: 256 DIKPENLLLGSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLW 313
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG + Y L G PPFE +ETY+ I +V +T P ++ AR L++ +L+ +P RP
Sbjct: 314 SLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPM 373
Query: 305 IDQILRHDFFT 315
+ ++L H + T
Sbjct: 374 LREVLEHPWIT 384
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 159 bits (401), Expect = 1e-38
Identities = 125/435 (28%), Positives = 199/435 (45%), Gaps = 38/435 (8%)
Query: 48 DPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSA-YAVKVIPQSRVAKPHQREK 106
+PGR T+ + + L+G G FA ++ E AVK I + +AK +
Sbjct: 2 EPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAK--SQTL 59
Query: 107 ILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYL 166
+ EI++ ++L+H +IV E A+++Y+ +E C+ LA A TL E +R +L
Sbjct: 60 LGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFL 119
Query: 167 RQILSGLKYLHQRGILHRDLKLGNFFIT---------ENMELKVGDFGLAARLEPPEQRK 217
+QI ++ LH +GI+HRDLK N ++ ++ +K+ DFG A L+
Sbjct: 120 QQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQ-SNMMA 178
Query: 218 KTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETA---DLKETYRCIKQ 274
T+CG+P Y+APEV++ Q + +AD+WS+G ++Y L G PF+ + DL+ Y K
Sbjct: 179 ATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKT 238
Query: 275 VHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDL 334
+ T+P S P RQLL A+L+ + +DR D+ H F + + P V VP
Sbjct: 239 LVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSP---PVPVPSY 295
Query: 335 TPPNPARSLFAKVTK------SLFGRKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPE 388
S + T SL ++ K A D L S R S G +D+ +
Sbjct: 296 PSSGSGSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSS--RDSGGSKDSSCD 353
Query: 389 AP---AASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFM 445
P LV AP P +L SG + V + L + +
Sbjct: 354 TDDFVMVPAQFPGDLVAEAPSAKPPPDSLMCSGS--------SLVASAGLESHGRTPSPS 405
Query: 446 PPAEQNPAPLAQPEP 460
PP +P+P + P
Sbjct: 406 PPCSSSPSPSGRAGP 420
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 152 bits (384), Expect = 9e-37
Identities = 87/263 (33%), Positives = 140/263 (53%), Gaps = 3/263 (1%)
Query: 62 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 121
Y + +GKG FA+ A TG AVK+I ++++ P +K+ E+ + + L H +
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL-NPTSLQKLFREVRIMKILNHPN 118
Query: 122 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 181
IV+ E +Y+ +E S + A + E E R RQI+S ++Y HQ+ I
Sbjct: 119 IVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYI 178
Query: 182 LHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPE 240
+HRDLK N + +M +K+ DFG + + T CG+P Y APE+ ++ GPE
Sbjct: 179 VHRDLKAENLLLDGDMNIKIADFGFSNEF-TVGNKLDTFCGSPPYAAPELFQGKKYDGPE 237
Query: 241 ADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPR 300
DVWSLG ++YTL+ GS PF+ +LKE + + Y +P +S LL +L +P
Sbjct: 238 VDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPI 297
Query: 301 DRPSIDQILRHDFFTKGYTPDRL 323
R S++QI++ + G+ + L
Sbjct: 298 KRGSLEQIMKDRWMNVGHEEEEL 320
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 151 bits (382), Expect = 2e-36
Identities = 85/259 (32%), Positives = 138/259 (53%), Gaps = 3/259 (1%)
Query: 66 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 125
+ +GKG FA+ A TG A+K+I ++++ P +K+ E+ + + L H +IV+
Sbjct: 60 KTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKL 118
Query: 126 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 185
E +Y+ +E S + A + E E R RQI+S ++Y HQ+ I+HRD
Sbjct: 119 FEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 186 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVW 244
LK N + +M +K+ DFG + + T CG+P Y APE+ ++ GPE DVW
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF-TVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG ++YTL+ GS PF+ +LKE + + Y +P +S LL L +P R +
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 305 IDQILRHDFFTKGYTPDRL 323
++QI++ + G+ D L
Sbjct: 298 LEQIMKDRWINAGHEEDEL 316
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 151 bits (382), Expect = 2e-36
Identities = 85/259 (32%), Positives = 138/259 (53%), Gaps = 3/259 (1%)
Query: 66 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 125
+ +GKG FA+ A TG A+K+I ++++ P +K+ E+ + + L H +IV+
Sbjct: 60 KTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKL 118
Query: 126 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 185
E +Y+ +E S + A + E E R RQI+S ++Y HQ+ I+HRD
Sbjct: 119 FEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 186 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVW 244
LK N + +M +K+ DFG + + T CG+P Y APE+ ++ GPE DVW
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF-TVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG ++YTL+ GS PF+ +LKE + + Y +P +S LL L +P R +
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 305 IDQILRHDFFTKGYTPDRL 323
++QI++ + G+ D L
Sbjct: 298 LEQIMKDRWINAGHEEDEL 316
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 151 bits (382), Expect = 2e-36
Identities = 85/259 (32%), Positives = 138/259 (53%), Gaps = 3/259 (1%)
Query: 66 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 125
+ +GKG FA+ A TG A+K+I ++++ P +K+ E+ + + L H +IV+
Sbjct: 60 KTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKL 118
Query: 126 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 185
E +Y+ +E S + A + E E R RQI+S ++Y HQ+ I+HRD
Sbjct: 119 FEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 186 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVW 244
LK N + +M +K+ DFG + + T CG+P Y APE+ ++ GPE DVW
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF-TVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG ++YTL+ GS PF+ +LKE + + Y +P +S LL L +P R +
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 305 IDQILRHDFFTKGYTPDRL 323
++QI++ + G+ D L
Sbjct: 298 LEQIMKDRWINAGHEEDEL 316
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 151 bits (382), Expect = 2e-36
Identities = 85/259 (32%), Positives = 138/259 (53%), Gaps = 3/259 (1%)
Query: 66 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 125
+ +GKG FA+ A TG A+K+I ++++ P +K+ E+ + + L H +IV+
Sbjct: 60 KTIGKGNFAKVKLARHILTGREVAIKIIDKTQL-NPTSLQKLFREVRIMKILNHPNIVKL 118
Query: 126 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 185
E +Y+ +E S + A + E E R RQI+S ++Y HQ+ I+HRD
Sbjct: 119 FEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRD 178
Query: 186 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVW 244
LK N + +M +K+ DFG + + T CG+P Y APE+ ++ GPE DVW
Sbjct: 179 LKAENLLLDADMNIKIADFGFSNEF-TVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 237
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG ++YTL+ GS PF+ +LKE + + Y +P +S LL L +P R +
Sbjct: 238 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGT 297
Query: 305 IDQILRHDFFTKGYTPDRL 323
++QI++ + G+ D L
Sbjct: 298 LEQIMKDRWINAGHEEDEL 316
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 149 bits (377), Expect = 6e-36
Identities = 98/319 (30%), Positives = 157/319 (49%), Gaps = 25/319 (7%)
Query: 11 RPFQRAAAAPAPPAGPGPPPSALRGPELEML------AGLPTSDPGRLITDPRSGRTYLK 64
RP + P P G GP + G E+ AG +DP LK
Sbjct: 24 RPRISQTSLPVPGPGSGPQRDSDEGVLKEISITHHVKAGSEKADPSHF--------ELLK 75
Query: 65 GRLLGKGGFARCY---EATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRH 121
+LG+G F + + + T ++G YA+KV+ ++ + K R + E ++ D+ H
Sbjct: 76 --VLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL-KVRDRVRTKMERDILADVNHPF 132
Query: 122 IVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGI 181
+V+ + F+ +Y+ L+ L E +V++YL ++ GL +LH GI
Sbjct: 133 VVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGI 192
Query: 182 LHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEA 241
++RDLK N + E +K+ DFGL+ E++ + CGT Y+APEV+ RQGH A
Sbjct: 193 IYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSA 252
Query: 242 DVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRD 301
D WS G +M+ +L GS PF+ D KET I + +P LS A+ LL A+ + +P +
Sbjct: 253 DWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQSLLRALFKRNPAN 312
Query: 302 R-----PSIDQILRHDFFT 315
R ++I RH F++
Sbjct: 313 RLGSGPDGAEEIKRHVFYS 331
Score = 125 bits (314), Expect = 1e-28
Identities = 106/358 (29%), Positives = 156/358 (43%), Gaps = 53/358 (14%)
Query: 12 PFQRAAAAP-------------APPAGPGPPPSA-----LRGPELEMLAGLPTSD----- 48
PF+ A A P P PG PPSA RG + GL D
Sbjct: 346 PFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSF-VATGLMEDDGKPRA 404
Query: 49 ---PGRLITDPRSGRT------YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVA 99
P + G+ Y+ +G G ++ C T YAVKVI +S+
Sbjct: 405 PQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRD 464
Query: 100 KPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLE 159
+ E +L R QH +I+ ++D ++Y+ EL L + E
Sbjct: 465 PSEEIEILL------RYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSE 518
Query: 160 PEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITE---NME-LKVGDFGLAARLEPPEQ 215
E + L I ++YLH +G++HRDLK N + N E L++ DFG A +L
Sbjct: 519 REASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENG 578
Query: 216 RKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADL---KETYRCI 272
T C T N+VAPEVL RQG+ D+WSLG ++YT+L G PF +E I
Sbjct: 579 LLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRI 638
Query: 273 KQVHYTLPA----SLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPIS 326
+TL ++S A+ L++ +L P R + Q+L+H + T+ D+LP S
Sbjct: 639 GSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQ---KDKLPQS 693
>gi|23943882 serine/threonine kinase 33 [Homo sapiens]
Length = 514
Score = 149 bits (377), Expect = 6e-36
Identities = 86/269 (31%), Positives = 142/269 (52%), Gaps = 17/269 (6%)
Query: 62 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILN-EIELHRDLQHR 120
Y GR+LGKG F EATD ET + +A+K + + + K+L E+ + + ++H
Sbjct: 116 YTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGS--SAVKLLEREVNILKSVKHE 173
Query: 121 HIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRG 180
HI+ FE +Y+ +ELC L I + E E R+ ++ + S + YLH
Sbjct: 174 HIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNND 233
Query: 181 ILHRDLKLGNFFITE---------NMELKVGDFGLAARLEP-PEQRKKTICGTPNYVAPE 230
I+HRDLKL N + N+ +KV DFGLA + + E + CGTP Y+APE
Sbjct: 234 IVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPE 293
Query: 231 VLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIK--QVHY--TLPASLSLP 286
V+ + + D+WS+G VMY LL G PPF + ++ + I+ ++H+ + S+S
Sbjct: 294 VISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDC 353
Query: 287 ARQLLAAILRASPRDRPSIDQILRHDFFT 315
A+ +L +++ P R + ++L + + T
Sbjct: 354 AKSVLKQLMKVDPAHRITAKELLDNQWLT 382
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 149 bits (376), Expect = 8e-36
Identities = 85/259 (32%), Positives = 137/259 (52%), Gaps = 3/259 (1%)
Query: 66 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 125
+ +GKG FA+ A TG AVK+I ++++ +K+ E+ + + L H +IV+
Sbjct: 57 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 126 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 185
E +Y+ +E S + A + E E R RQI+S ++Y HQ+ I+HRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 186 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVW 244
LK N + +M +K+ DFG + + T CG+P Y APE+ ++ GPE DVW
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEF-TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG ++YTL+ GS PF+ +LKE + + Y +P +S LL L +P R +
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
Query: 305 IDQILRHDFFTKGYTPDRL 323
++QI++ + G+ D L
Sbjct: 295 LEQIMKDRWMNVGHEDDEL 313
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 149 bits (376), Expect = 8e-36
Identities = 85/259 (32%), Positives = 137/259 (52%), Gaps = 3/259 (1%)
Query: 66 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 125
+ +GKG FA+ A TG AVK+I ++++ +K+ E+ + + L H +IV+
Sbjct: 57 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 126 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 185
E +Y+ +E S + A + E E R RQI+S ++Y HQ+ I+HRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 186 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVW 244
LK N + +M +K+ DFG + + T CG+P Y APE+ ++ GPE DVW
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEF-TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG ++YTL+ GS PF+ +LKE + + Y +P +S LL L +P R +
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
Query: 305 IDQILRHDFFTKGYTPDRL 323
++QI++ + G+ D L
Sbjct: 295 LEQIMKDRWMNVGHEDDEL 313
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 149 bits (376), Expect = 8e-36
Identities = 85/259 (32%), Positives = 137/259 (52%), Gaps = 3/259 (1%)
Query: 66 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 125
+ +GKG FA+ A TG AVK+I ++++ +K+ E+ + + L H +IV+
Sbjct: 57 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 126 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 185
E +Y+ +E S + A + E E R RQI+S ++Y HQ+ I+HRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 186 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVW 244
LK N + +M +K+ DFG + + T CG+P Y APE+ ++ GPE DVW
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEF-TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG ++YTL+ GS PF+ +LKE + + Y +P +S LL L +P R +
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
Query: 305 IDQILRHDFFTKGYTPDRL 323
++QI++ + G+ D L
Sbjct: 295 LEQIMKDRWMNVGHEDDEL 313
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 149 bits (376), Expect = 8e-36
Identities = 85/259 (32%), Positives = 137/259 (52%), Gaps = 3/259 (1%)
Query: 66 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 125
+ +GKG FA+ A TG AVK+I ++++ +K+ E+ + + L H +IV+
Sbjct: 57 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKL 115
Query: 126 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 185
E +Y+ +E S + A + E E R RQI+S ++Y HQ+ I+HRD
Sbjct: 116 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 175
Query: 186 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVW 244
LK N + +M +K+ DFG + + T CG+P Y APE+ ++ GPE DVW
Sbjct: 176 LKAENLLLDADMNIKIADFGFSNEF-TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 234
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG ++YTL+ GS PF+ +LKE + + Y +P +S LL L +P R +
Sbjct: 235 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 294
Query: 305 IDQILRHDFFTKGYTPDRL 323
++QI++ + G+ D L
Sbjct: 295 LEQIMKDRWMNVGHEDDEL 313
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 149 bits (376), Expect = 8e-36
Identities = 85/259 (32%), Positives = 137/259 (52%), Gaps = 3/259 (1%)
Query: 66 RLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRF 125
+ +GKG FA+ A TG AVK+I ++++ +K+ E+ + + L H +IV+
Sbjct: 24 KTIGKGNFAKVKLARHILTGKEVAVKIIDKTQL-NSSSLQKLFREVRIMKVLNHPNIVKL 82
Query: 126 SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRD 185
E +Y+ +E S + A + E E R RQI+S ++Y HQ+ I+HRD
Sbjct: 83 FEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRD 142
Query: 186 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVW 244
LK N + +M +K+ DFG + + T CG+P Y APE+ ++ GPE DVW
Sbjct: 143 LKAENLLLDADMNIKIADFGFSNEF-TFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVW 201
Query: 245 SLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304
SLG ++YTL+ GS PF+ +LKE + + Y +P +S LL L +P R +
Sbjct: 202 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGT 261
Query: 305 IDQILRHDFFTKGYTPDRL 323
++QI++ + G+ D L
Sbjct: 262 LEQIMKDRWMNVGHEDDEL 280
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 149 bits (376), Expect = 8e-36
Identities = 88/253 (34%), Positives = 139/253 (54%), Gaps = 4/253 (1%)
Query: 68 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSH 127
+G GGFA+ A TG A+K++ ++ + R K EIE ++L+H+HI + H
Sbjct: 17 IGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIK--TEIEALKNLRHQHICQLYH 74
Query: 128 HFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLK 187
E A+ I++ LE C L ++ L E E R RQI+S + Y+H +G HRDLK
Sbjct: 75 VLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLK 134
Query: 188 LGNFFITENMELKVGDFGLAARLE-PPEQRKKTICGTPNYVAPEVLLRQGH-GPEADVWS 245
N E +LK+ DFGL A+ + + +T CG+ Y APE++ + + G EADVWS
Sbjct: 135 PENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWS 194
Query: 246 LGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSI 305
+G ++Y L+CG PF+ ++ Y+ I + Y +P LS + LL +L+ P+ R S+
Sbjct: 195 MGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISM 254
Query: 306 DQILRHDFFTKGY 318
+L H + + Y
Sbjct: 255 KNLLNHPWIMQDY 267
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,440,289
Number of Sequences: 37866
Number of extensions: 1566770
Number of successful extensions: 13089
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 763
Number of HSP's successfully gapped in prelim test: 166
Number of HSP's that attempted gapping in prelim test: 10180
Number of HSP's gapped (non-prelim): 1643
length of query: 646
length of database: 18,247,518
effective HSP length: 109
effective length of query: 537
effective length of database: 14,120,124
effective search space: 7582506588
effective search space used: 7582506588
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.