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Search of human proteins with 41393057
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41393057 connector enhancer of kinase suppressor of Ras 2
[Homo sapiens]
(1034 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho... 2103 0.0
gi|74316006 CNKSR family member 3 [Homo sapiens] 576 e-164
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 270 5e-72
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 270 5e-72
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 269 9e-72
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H... 199 1e-50
gi|219689123 pleckstrin homology domain containing, family A mem... 77 1e-13
gi|19923493 pleckstrin homology domain containing, family A memb... 77 1e-13
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 70 1e-11
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 62 2e-09
gi|239047795 pleckstrin homology domain containing, family A mem... 59 3e-08
gi|238859653 pleckstrin homology domain containing family A memb... 55 4e-07
gi|238859651 pleckstrin homology domain containing family A memb... 55 4e-07
gi|115527076 src kinase associated phosphoprotein 1 isoform 2 [H... 54 6e-07
gi|115527074 src kinase associated phosphoprotein 1 isoform 1 [H... 54 6e-07
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 49 2e-05
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 49 2e-05
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 49 2e-05
gi|154354979 myosin X [Homo sapiens] 49 2e-05
gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens] 49 2e-05
gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa... 47 1e-04
gi|7019505 cytohesin 4 [Homo sapiens] 46 2e-04
gi|83716021 GRB2-associated binding protein family, member 4 [Ho... 46 2e-04
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 46 2e-04
gi|148762982 hypothetical protein LOC387640 [Homo sapiens] 45 4e-04
gi|156119595 sterile alpha motif domain containing 12 isoform b ... 45 5e-04
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 44 6e-04
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 44 6e-04
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 44 6e-04
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 44 6e-04
>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
sapiens]
Length = 1034
Score = 2103 bits (5449), Expect = 0.0
Identities = 1034/1034 (100%), Positives = 1034/1034 (100%)
Query: 1 MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRI 60
MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRI
Sbjct: 1 MALIMEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRI 60
Query: 61 GHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKL 120
GHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKL
Sbjct: 61 GHQELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKL 120
Query: 121 PNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYET 180
PNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYET
Sbjct: 121 PNDFLTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYET 180
Query: 181 ENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHV 240
ENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHV
Sbjct: 181 ENKILHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHV 240
Query: 241 ITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM 300
ITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM
Sbjct: 241 ITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSM 300
Query: 301 LTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEP 360
LTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEP
Sbjct: 301 LTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEP 360
Query: 361 YIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKG 420
YIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKG
Sbjct: 361 YIPRDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKG 420
Query: 421 RSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQE 480
RSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQE
Sbjct: 421 RSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQE 480
Query: 481 EYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQ 540
EYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQ
Sbjct: 481 EYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQ 540
Query: 541 SSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKD 600
SSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKD
Sbjct: 541 SSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKD 600
Query: 601 ASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRW 660
ASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRW
Sbjct: 601 ASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRW 660
Query: 661 LNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCAS 720
LNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCAS
Sbjct: 661 LNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCAS 720
Query: 721 PYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSG 780
PYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSG
Sbjct: 721 PYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSG 780
Query: 781 LHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGG 840
LHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGG
Sbjct: 781 LHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGG 840
Query: 841 KPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSES 900
KPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSES
Sbjct: 841 KPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSES 900
Query: 901 REEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKS 960
REEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKS
Sbjct: 901 REEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKS 960
Query: 961 TLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVIT 1020
TLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVIT
Sbjct: 961 TLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQNTTSNDPLSISSEVDVIT 1020
Query: 1021 SSLAHTHSYIETHV 1034
SSLAHTHSYIETHV
Sbjct: 1021 SSLAHTHSYIETHV 1034
>gi|74316006 CNKSR family member 3 [Homo sapiens]
Length = 555
Score = 576 bits (1484), Expect = e-164
Identities = 296/476 (62%), Positives = 358/476 (75%), Gaps = 9/476 (1%)
Query: 5 MEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQE 64
MEPV+KWSP QVVDW +GLDDCLQQY+ FEREKI+G+QLL+I+HQ+LE+LGV+RIGHQE
Sbjct: 1 MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQE 60
Query: 65 LILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDF 124
L+LEAVDLLCALNYGLET+N+K L KL AS+ NLQN+I+ RR+S YDG TSRK PN+F
Sbjct: 61 LVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEF 120
Query: 125 LTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKI 184
LTSVV+LIGAAK+LLAWLDR+PF +TD+SVT+N +IQLCL+LTT VQ+DC V E E+K+
Sbjct: 121 LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKV 180
Query: 185 LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGT 244
L V K L+G+CD I ++DP++SQ A LE + L NIKP EGLGMYIKSTYDGLHVITGT
Sbjct: 181 LTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGT 240
Query: 245 TENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSA 304
TENSPADR +KIHAGDEVIQVN QTVVGWQLKNLV LRE+P+GV+L LKKRP
Sbjct: 241 TENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFT 300
Query: 305 PALLKNMRWKPLALQPLIPRS-PTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIP 363
PA LKN+RWKP PL+ S P ++ +P ST+ T K++ SA+ DLYIPPPPA PY P
Sbjct: 301 PAPLKNLRWKP----PLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSP 356
Query: 364 RDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSS 423
RDE G+ P KGSESPNSFLDQE R+R + + L Y E
Sbjct: 357 RDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILP 416
Query: 424 SQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRR--ENSLLRYMSNEKI 477
++ RE TP+YGK RP+SMP + NW+G DP R R E++L RY SNE+I
Sbjct: 417 TK-MREKTPSYGKPRPLSMPADGNWMG-IVDPFARPRGHGRKGEDALCRYFSNERI 470
>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [Homo
sapiens]
Length = 438
Score = 270 bits (690), Expect = 5e-72
Identities = 164/463 (35%), Positives = 256/463 (55%), Gaps = 68/463 (14%)
Query: 540 QSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLK 599
Q L+ K ++K +G + S+RRISCKDLG DC+GWL+KKK+ S+ S KWKK+W +LK
Sbjct: 13 QVPLRQKPRRKTQGFLT-MSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILK 71
Query: 600 DASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR 659
+SLYWY N+ EKA+GF++LP+F ++RASEC+KK+AFK HP+IK+FYFAAE++ +MN
Sbjct: 72 GSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNV 131
Query: 660 WLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCA 719
WLN+ L + +E ++++ +SES++E+ + + ++PPPP+
Sbjct: 132 WLNK---LGSAVIHQESTTKDEECYSESEQEDPEIAA----ETPPPPH------------ 172
Query: 720 SPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSS 779
SQ+QS + SS+ + T+ S ++ ++TP +
Sbjct: 173 ---------------ASQTQSLTAQ-----QASSSSPSLSGTSYSFSSLENTVKTPSSFP 212
Query: 780 GLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNG 839
+ L D+V S SAA + + T Q + P P + N
Sbjct: 213 SSLSKERQSLPDTVNSLSAA--EDEGQPITFAVQV------HSPVPSEAGIHKALEN--- 261
Query: 840 GKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSE 899
SF N + S D + P+ + AG I +K E
Sbjct: 262 ----SFVTSESGFLNSLSSDDTSSLSSNHDHLTVPD------------KPAGSKIMDKEE 305
Query: 900 SREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILK 959
++ + D ++ LY++LEQASLSPLG+ R STK E + SF+KRC +P +NEKLH++R L
Sbjct: 306 TKVSE-DDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLN 364
Query: 960 STLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQ 1002
STLK +E ++A+I+++LD+P LT++++++WK M L DI Q
Sbjct: 365 STLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQ 407
>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [Homo
sapiens]
Length = 438
Score = 270 bits (690), Expect = 5e-72
Identities = 164/463 (35%), Positives = 256/463 (55%), Gaps = 68/463 (14%)
Query: 540 QSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLK 599
Q L+ K ++K +G + S+RRISCKDLG DC+GWL+KKK+ S+ S KWKK+W +LK
Sbjct: 13 QVPLRQKPRRKTQGFLT-MSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILK 71
Query: 600 DASLYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNR 659
+SLYWY N+ EKA+GF++LP+F ++RASEC+KK+AFK HP+IK+FYFAAE++ +MN
Sbjct: 72 GSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNV 131
Query: 660 WLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCA 719
WLN+ L + +E ++++ +SES++E+ + + ++PPPP+
Sbjct: 132 WLNK---LGSAVIHQESTTKDEECYSESEQEDPEIAA----ETPPPPH------------ 172
Query: 720 SPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSS 779
SQ+QS + SS+ + T+ S ++ ++TP +
Sbjct: 173 ---------------ASQTQSLTAQ-----QASSSSPSLSGTSYSFSSLENTVKTPSSFP 212
Query: 780 GLHYLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNG 839
+ L D+V S SAA + + T Q + P P + N
Sbjct: 213 SSLSKERQSLPDTVNSLSAA--EDEGQPITFAVQV------HSPVPSEAGIHKALEN--- 261
Query: 840 GKPRSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSE 899
SF N + S D + P+ + AG I +K E
Sbjct: 262 ----SFVTSESGFLNSLSSDDTSSLSSNHDHLTVPD------------KPAGSKIMDKEE 305
Query: 900 SREEKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILK 959
++ + D ++ LY++LEQASLSPLG+ R STK E + SF+KRC +P +NEKLH++R L
Sbjct: 306 TKVSE-DDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLN 364
Query: 960 STLKAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQ 1002
STLK +E ++A+I+++LD+P LT++++++WK M L DI Q
Sbjct: 365 STLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQ 407
>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
sapiens]
Length = 437
Score = 269 bits (688), Expect = 9e-72
Identities = 163/460 (35%), Positives = 255/460 (55%), Gaps = 68/460 (14%)
Query: 543 LQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDAS 602
L+ K ++K +G + S+RRISCKDLG DC+GWL+KKK+ S+ S KWKK+W +LK +S
Sbjct: 15 LRQKPRRKTQGFLT-MSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS 73
Query: 603 LYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLN 662
LYWY N+ EKA+GF++LP+F ++RASEC+KK+AFK HP+IK+FYFAAE++ +MN WLN
Sbjct: 74 LYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLN 133
Query: 663 RINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPY 722
+ L + +E ++++ +SES++E+ + + ++PPPP+
Sbjct: 134 K---LGSAVIHQESTTKDEECYSESEQEDPEIAA----ETPPPPH--------------- 171
Query: 723 VEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLH 782
SQ+QS + SS+ + T+ S ++ ++TP +
Sbjct: 172 ------------ASQTQSLTAQ-----QASSSSPSLSGTSYSFSSLENTVKTPSSFPSSL 214
Query: 783 YLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKP 842
+ L D+V S SAA + + T Q + P P + N
Sbjct: 215 SKERQSLPDTVNSLSAA--EDEGQPITFAVQV------HSPVPSEAGIHKALEN------ 260
Query: 843 RSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESRE 902
SF N + S D + P+ + AG I +K E++
Sbjct: 261 -SFVTSESGFLNSLSSDDTSSLSSNHDHLTVPD------------KPAGSKIMDKEETKV 307
Query: 903 EKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTL 962
+ D ++ LY++LEQASLSPLG+ R STK E + SF+KRC +P +NEKLH++R L STL
Sbjct: 308 SE-DDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTL 366
Query: 963 KAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQ 1002
K +E ++A+I+++LD+P LT++++++WK M L DI Q
Sbjct: 367 KCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQ 406
>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
sapiens]
Length = 713
Score = 199 bits (506), Expect = 1e-50
Identities = 129/367 (35%), Positives = 196/367 (53%), Gaps = 24/367 (6%)
Query: 5 MEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQE 64
MEPV W+P +V W++GLDD LQ Y FE ++ G LL++ Q LE L V +GHQE
Sbjct: 1 MEPVETWTPGKVATWLRGLDDSLQDY--PFEDWQLPGKNLLQLCPQSLEALAVRSLGHQE 58
Query: 65 LILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDF 124
LIL V+ L AL+ L+TENL++L+ L + + Q+ + G K P D
Sbjct: 59 LILGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGD-------CAKTPIDV 111
Query: 125 LTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKI 184
L + V+L+ A +LL WL R F+ + D+S + + L EL+ ++ +D E E +
Sbjct: 112 LCAAVELLHEADALLFWLSRYLFSHLNDFSACQE-IRDLLEELSQVLHEDGPAAEKEGTV 170
Query: 185 LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGT 244
L +C ++G+C +I+ L+ Q A LE +QL LG+ I +T + H ++
Sbjct: 171 LRICSHVAGICHNILVCCPKELLEQKAVLEQVQL-----DSPLGLEIHTTSNCQHFVSQV 225
Query: 245 TENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKK--RPQSMLT 302
P D +I GDEV+Q+N Q VVGW KN+V L +P+G+ L LKK P++
Sbjct: 226 DTQVPTDSRLQIQPGDEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQ 285
Query: 303 SAPALL--KNMRWKPLALQPLIPRSPTSSV-----ATPSSTISTPTKRDSSALQDLYIPP 355
+ P +L + R L+L PL PR+P+ V ++ S +P DS++L +P
Sbjct: 286 TPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPI 345
Query: 356 PPAEPYI 362
PP P I
Sbjct: 346 PPEPPAI 352
Score = 128 bits (321), Expect = 3e-29
Identities = 59/160 (36%), Positives = 94/160 (58%), Gaps = 2/160 (1%)
Query: 548 KKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYI 607
+KK+KG S+RR+SC++LGR DC+GWL +K + +W++ WFVLK +LYWY
Sbjct: 374 RKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYR 433
Query: 608 NEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINML 667
+DEKAEG I++ + ++ + +KKY F+ H K F FAA+ L D++ W+ +
Sbjct: 434 QPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITC 493
Query: 668 TAGYAERERI--KQEQDYWSESDKEEADTPSTPKQDSPPP 705
+ Y R +E+D +SE++ E+ D + SP P
Sbjct: 494 ISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSP 533
Score = 84.7 bits (208), Expect = 4e-16
Identities = 47/151 (31%), Positives = 84/151 (55%), Gaps = 13/151 (8%)
Query: 848 PRDSGFNHCCLNAPVSACDP-QDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLG 906
P D +H +P A P D P + + G ++S EE
Sbjct: 520 PDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRT--------SFGSLTDSSEE--- 568
Query: 907 DSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKARE 966
+L+ + R L Q +S LG+ + T+ +++ SF++R DP +NE++HR+R L+STLKA+
Sbjct: 569 -ALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLKAKL 627
Query: 967 GEVAIIDKVLDNPDLTSKEFQQWKQMYLDLF 997
E+ ++++VL +P+LT ++F+QWK+ +L+
Sbjct: 628 QELQVLEEVLGDPELTGEKFRQWKEQNRELY 658
>gi|219689123 pleckstrin homology domain containing, family A member
5 isoform 2 [Homo sapiens]
Length = 1105
Score = 76.6 bits (187), Expect = 1e-13
Identities = 53/170 (31%), Positives = 79/170 (46%), Gaps = 10/170 (5%)
Query: 532 TTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKW 591
T+ Y S + S+ K GK I GWL+K+ S + W
Sbjct: 23 TSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD---STGMKLW 79
Query: 592 KKYWFVLKDASLYWYINEEDEKAEGFISLPEFKI---DRASECRKKYAFKACHPKIKSFY 648
KK WFVL D L++Y +E++E G I LP F+I +KYAFKA HP ++++Y
Sbjct: 80 KKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYY 139
Query: 649 FAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSES--DKEEADTPS 696
F + +M W+ ML A + E +K+ SE+ KE + P+
Sbjct: 140 FCTDTGKEMELWMKA--MLDAALVQTEPVKRVDKITSENAPTKETNNIPN 187
>gi|19923493 pleckstrin homology domain containing, family A member
5 isoform 1 [Homo sapiens]
Length = 1116
Score = 76.6 bits (187), Expect = 1e-13
Identities = 53/170 (31%), Positives = 79/170 (46%), Gaps = 10/170 (5%)
Query: 532 TTLYHTFQQSSLQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKW 591
T+ Y S + S+ K GK I GWL+K+ S + W
Sbjct: 131 TSDYAVHPMSPVGRTSRASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQD---STGMKLW 187
Query: 592 KKYWFVLKDASLYWYINEEDEKAEGFISLPEFKI---DRASECRKKYAFKACHPKIKSFY 648
KK WFVL D L++Y +E++E G I LP F+I +KYAFKA HP ++++Y
Sbjct: 188 KKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHINRKYAFKAAHPNMRTYY 247
Query: 649 FAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSES--DKEEADTPS 696
F + +M W+ ML A + E +K+ SE+ KE + P+
Sbjct: 248 FCTDTGKEMELWMKA--MLDAALVQTEPVKRVDKITSENAPTKETNNIPN 295
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 69.7 bits (169), Expect = 1e-11
Identities = 43/155 (27%), Positives = 76/155 (49%), Gaps = 15/155 (9%)
Query: 575 GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFK---IDRASEC 631
GWL+K+ + ++W K WFVL D L++Y +E++E G I L F+ + +
Sbjct: 64 GWLFKQASSGV---KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120
Query: 632 RKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEE 691
+K+ FKA H +++++F+AE ++ W+ + G A R +I Q ++ +
Sbjct: 121 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAM-----GEAARVQIPPAQKSVPQAVRHS 175
Query: 692 ADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAK 726
+ P + PP + +PP S P EAK
Sbjct: 176 HEKPDSEN----VPPSKHHQQPPHNSLPKPEPEAK 206
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 62.4 bits (150), Expect = 2e-09
Identities = 45/140 (32%), Positives = 70/140 (50%), Gaps = 14/140 (10%)
Query: 222 KPSEGLGMYI---------KSTYDGLHVITGTTENSPADRCKKIHAGDEVIQVNHQTVVG 272
K +EG G I ST H I + SPADRC K+ GD ++ VN Q+++
Sbjct: 926 KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIIN 985
Query: 273 WQLKNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQ-PLIPRSPTS--S 329
++V +++ +G+ +TL+ PQ L S + + + P+A Q PL +SP + S
Sbjct: 986 MPHADIVKLIKD--AGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPS 1043
Query: 330 VATPSSTISTPTKRDSSALQ 349
ATP+S I+ P LQ
Sbjct: 1044 PATPNSPIAQPAPPQPLQLQ 1063
Score = 30.8 bits (68), Expect = 6.9
Identities = 35/155 (22%), Positives = 63/155 (40%), Gaps = 32/155 (20%)
Query: 194 VCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGTTENSPADRC 253
V D +S++S S + E++ L +K ++G G I + G V + C
Sbjct: 586 VHDDNVSMAS----SGATQAELMTLTIVKGAQGFGFTIADSPTGQRV----KQILDIQGC 637
Query: 254 KKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTL-------------------- 293
+ GD ++++N Q V +V+ L++ P G +L
Sbjct: 638 PGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDR 697
Query: 294 ---KKRPQSMLTSAPALLKNMRWKPLALQPLIPRS 325
+ PQ+ L SAPA+ +N+ + P + P S
Sbjct: 698 WENQGSPQTSL-SAPAIPQNLPFPPALHRSSFPDS 731
>gi|239047795 pleckstrin homology domain containing, family A member
7 [Homo sapiens]
Length = 1121
Score = 58.5 bits (140), Expect = 3e-08
Identities = 36/130 (27%), Positives = 61/130 (46%), Gaps = 26/130 (20%)
Query: 575 GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRAS---EC 631
GWL K+ + + WK+ WFVL D L++Y + +E G I LP + I +
Sbjct: 169 GWLHKQDSSGM---RLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRI 225
Query: 632 RKKYAFKACH-------------------PKIKSFYFAAEHLDDMNRWLNRINMLTAGYA 672
+KY+FKA H ++++YF+A+ +DMN W+ +N A
Sbjct: 226 SRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQ-AAQVL 284
Query: 673 ERERIKQEQD 682
R +K++ +
Sbjct: 285 SRSSLKRDME 294
>gi|238859653 pleckstrin homology domain containing family A member
4 isoform 2 [Homo sapiens]
Length = 583
Score = 54.7 bits (130), Expect = 4e-07
Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 6/93 (6%)
Query: 575 GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKI--DRASECR 632
GWL K+ + + WK+ WFVL L++Y + +E G + LP + I D R
Sbjct: 59 GWLHKQDSSGL---RLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPR 115
Query: 633 -KKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI 664
+++ F A HP ++++ AA+ L+D+ WL +
Sbjct: 116 GRRFTFTAEHPGMRTYVLAADTLEDLRGWLRAL 148
>gi|238859651 pleckstrin homology domain containing family A member
4 isoform 1 [Homo sapiens]
Length = 779
Score = 54.7 bits (130), Expect = 4e-07
Identities = 29/93 (31%), Positives = 50/93 (53%), Gaps = 6/93 (6%)
Query: 575 GWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKI--DRASECR 632
GWL K+ + + WK+ WFVL L++Y + +E G + LP + I D R
Sbjct: 59 GWLHKQDSSGL---RLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPR 115
Query: 633 -KKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI 664
+++ F A HP ++++ AA+ L+D+ WL +
Sbjct: 116 GRRFTFTAEHPGMRTYVLAADTLEDLRGWLRAL 148
>gi|115527076 src kinase associated phosphoprotein 1 isoform 2 [Homo
sapiens]
Length = 358
Score = 54.3 bits (129), Expect = 6e-07
Identities = 35/141 (24%), Positives = 66/141 (46%), Gaps = 13/141 (9%)
Query: 574 EGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECR- 632
+G+L KK S+F +W+K W V+ Y+Y NE+ ++ +G + + + A R
Sbjct: 111 QGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRR 170
Query: 633 ---KKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINM-------LTAGYAERERIKQEQD 682
K+ F+ +S+ F A + W+++I+ LT Y E E +++++
Sbjct: 171 DSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEE 230
Query: 683 YWSESDKEEADTPSTPKQDSP 703
+ + D D+PS Q P
Sbjct: 231 TYDDID--GFDSPSCGSQCRP 249
>gi|115527074 src kinase associated phosphoprotein 1 isoform 1 [Homo
sapiens]
Length = 359
Score = 54.3 bits (129), Expect = 6e-07
Identities = 35/141 (24%), Positives = 66/141 (46%), Gaps = 13/141 (9%)
Query: 574 EGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASECR- 632
+G+L KK S+F +W+K W V+ Y+Y NE+ ++ +G + + + A R
Sbjct: 111 QGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRR 170
Query: 633 ---KKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINM-------LTAGYAERERIKQEQD 682
K+ F+ +S+ F A + W+++I+ LT Y E E +++++
Sbjct: 171 DSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEE 230
Query: 683 YWSESDKEEADTPSTPKQDSP 703
+ + D D+PS Q P
Sbjct: 231 TYDDID--GFDSPSCGSQCRP 249
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 49.3 bits (116), Expect = 2e-05
Identities = 23/65 (35%), Positives = 39/65 (60%), Gaps = 2/65 (3%)
Query: 6 EPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQEL 65
+PV KW +V W+ L+ L +Y F R I G +LL + ++L+DLG+ ++GH +
Sbjct: 1146 QPVQKWGTEEVAAWLDLLN--LGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGHVKR 1203
Query: 66 ILEAV 70
IL+ +
Sbjct: 1204 ILQGI 1208
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 49.3 bits (116), Expect = 2e-05
Identities = 23/61 (37%), Positives = 36/61 (59%), Gaps = 2/61 (3%)
Query: 7 PVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELI 66
PV W +V W++ L C +Y F R I G +LL + ++L+DLGV+++GH + I
Sbjct: 1097 PVHLWGTEEVAAWLEHLSLC--EYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRI 1154
Query: 67 L 67
L
Sbjct: 1155 L 1155
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 49.3 bits (116), Expect = 2e-05
Identities = 23/61 (37%), Positives = 36/61 (59%), Gaps = 2/61 (3%)
Query: 7 PVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQELI 66
PV W +V W++ L C +Y F R I G +LL + ++L+DLGV+++GH + I
Sbjct: 1141 PVHLWGTEEVAAWLEHLSLC--EYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRI 1198
Query: 67 L 67
L
Sbjct: 1199 L 1199
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 48.9 bits (115), Expect = 2e-05
Identities = 29/99 (29%), Positives = 53/99 (53%), Gaps = 7/99 (7%)
Query: 574 EGWLWKKKDAKSYFSQK-WKKYWFVLKDASLYWYINEEDEKAEGFISLPEFK--IDRASE 630
+GWL KK S S++ WKK WFVL+ + L ++ N+ +EK +G + + K ID ++
Sbjct: 1216 QGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEVRTAKEIIDNTTK 1275
Query: 631 CRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTA 669
A ++F+ AE +D ++W + ++ + A
Sbjct: 1276 ENGIDIIMA----DRTFHLIAESPEDASQWFSVLSQVHA 1310
Score = 30.8 bits (68), Expect = 6.9
Identities = 10/35 (28%), Positives = 20/35 (57%)
Query: 584 KSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFI 618
K WK+ W VLKD + W+ ++++ +G++
Sbjct: 1185 KGGLMNSWKRRWCVLKDETFLWFRSKQEALKQGWL 1219
Score = 30.4 bits (67), Expect = 9.0
Identities = 17/37 (45%), Positives = 22/37 (59%), Gaps = 1/37 (2%)
Query: 575 GWLWKK-KDAKSYFSQKWKKYWFVLKDASLYWYINEE 610
GWL K+ K++ S K KK WFVL SL +Y + E
Sbjct: 1397 GWLHKEVKNSPKMSSLKLKKRWFVLTHNSLDYYKSSE 1433
>gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens]
Length = 359
Score = 48.9 bits (115), Expect = 2e-05
Identities = 42/194 (21%), Positives = 81/194 (41%), Gaps = 9/194 (4%)
Query: 549 KKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYIN 608
K ++ P G I+ +DL G+L K++ S+ +W+K W L Y+Y +
Sbjct: 95 KDDEAPSDGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGS 154
Query: 609 EEDEKAEGFISLPEFKIDRASECR----KKYAFKACHPKIKSFYFAAEHLDDMNRWLNRI 664
++D++ +G ++ + + + R K F+ P + + F A D W+ ++
Sbjct: 155 DKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQL 214
Query: 665 NMLTAGYAERERIKQEQDYWSESDKEEADTP---STPKQDSPPPPYDTYPRPPSMSCASP 721
+ E + I ++ D E ++ D P S P S P + Y P S
Sbjct: 215 KFVLQD-MESDIIPEDYDERGEL-YDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSA 272
Query: 722 YVEAKHSRLSSTET 735
V+ + R S ++
Sbjct: 273 PVKVEEQRKMSQDS 286
>gi|18105042 GRB2-associated binding protein 2 isoform a [Homo
sapiens]
Length = 676
Score = 46.6 bits (109), Expect = 1e-04
Identities = 50/189 (26%), Positives = 73/189 (38%), Gaps = 38/189 (20%)
Query: 569 GRGD--CEGWLWKKKDAKSYFSQKWKKYWFVLKDAS-------LYWYINEEDEKAEGFIS 619
G GD C GWL K K WKK WF+L+ L +Y N+ +K I+
Sbjct: 3 GGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIIN 62
Query: 620 LPEF--KIDRASECRKKYAFKACHPKIK----SFYFAAEHLDDMNRWLNRI--------- 664
L F ++D KK + IK +FY AE +DMN+W+ I
Sbjct: 63 L-NFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQA 121
Query: 665 --------NMLTAGYAER----ERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPR 712
N+ +AG+ R E Q E S P + PP + +
Sbjct: 122 EESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQ 181
Query: 713 PPSMSCASP 721
P++S ++P
Sbjct: 182 -PTLSTSAP 189
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 46.2 bits (108), Expect = 2e-04
Identities = 32/120 (26%), Positives = 50/120 (41%), Gaps = 15/120 (12%)
Query: 572 DCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASEC 631
D EGWL K + WK+ WF+L D LY++ D++ G I L + + +
Sbjct: 261 DREGWLLKLGGRV----KTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDDP 316
Query: 632 RKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIK----QEQDYWSES 687
+K + + +P + A D R + G E RI +E+D W ES
Sbjct: 317 KKPFCLELYNPSCRGQKIKACKTDGDGR-------VVEGKHESYRISATSAEERDQWIES 369
>gi|83716021 GRB2-associated binding protein family, member 4 [Homo
sapiens]
Length = 574
Score = 45.8 bits (107), Expect = 2e-04
Identities = 50/209 (23%), Positives = 79/209 (37%), Gaps = 20/209 (9%)
Query: 575 GWLWKKKDAKSYFSQKWKKYWFVLKDAS-------LYWYINEEDEKAEGFISL---PEFK 624
GWL K K W+K WF+L+ L +Y N+ +K I+L +
Sbjct: 44 GWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINLNLCEQLD 103
Query: 625 IDRASECRKKYAFKACHPKIK----SFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQE 680
+D KK K IK +FY AE +DMN W+ I + G+ + E
Sbjct: 104 VDVTLNFNKKEIQKGYMFDIKTSERTFYLVAETREDMNEWVQSICQI-CGFRQEESTGFL 162
Query: 681 QDYWSESDKEEADTPSTPKQDSPPPPYDTYP--RPPSMSCASPY--VEAKHSRLSSTETS 736
+ S + +P+ P P + P PP C P + A L S + +
Sbjct: 163 GNI-SSASHGLCSSPAEPSCSHQHLPQEQEPTSEPPVSHCVPPTWPIPAPPGCLRSHQHA 221
Query: 737 QSQSSHEEFRQEVTGSSAVSPIRKTASQR 765
++ H GS A +R+ + +
Sbjct: 222 SQRAEHARSASFSQGSEAPFIMRRNTAMQ 250
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 45.8 bits (107), Expect = 2e-04
Identities = 32/116 (27%), Positives = 50/116 (43%), Gaps = 6/116 (5%)
Query: 572 DCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASEC 631
D EGWL K + + WK+ WF+L D LY++ D++ G I L I +
Sbjct: 261 DREGWLLKLGGGRV---KTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDP 317
Query: 632 RKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSES 687
RK F+ P K A + R + +M+ Y ++E+D W +S
Sbjct: 318 RKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMV---YRISAPTQEEKDEWIKS 370
>gi|148762982 hypothetical protein LOC387640 [Homo sapiens]
Length = 908
Score = 45.1 bits (105), Expect = 4e-04
Identities = 45/171 (26%), Positives = 64/171 (37%), Gaps = 15/171 (8%)
Query: 804 HRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKPRSFTLPRDSGFNHCCLNAPVS 863
H ++ P Q H H+ P P S + + S DS F ++ S
Sbjct: 349 HHHRAQPPQQSHHPPHHHRPQPHLGSFPESCSSDSESSSYSDHAANDSDFGSSLSSSSNS 408
Query: 864 ACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLGDSLQDLYRALEQASLSP 923
+++ E EEEEEEEEEEG + + E S E+ +S D Q S+
Sbjct: 409 VSSEEEE---EEGEEEEEEEEEEGGSGASDSSEVSSEEEDSSTES--DSSSGSSQVSVQS 463
Query: 924 LGEHRIS----------TKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKA 964
+ R S Y L+ P E RL LKS++KA
Sbjct: 464 IRFRRTSFCKPPSVQAQANFLYHLASAAAATKPAAFEDAGRLPDLKSSVKA 514
>gi|156119595 sterile alpha motif domain containing 12 isoform b
[Homo sapiens]
Length = 201
Score = 44.7 bits (104), Expect = 5e-04
Identities = 38/144 (26%), Positives = 66/144 (45%), Gaps = 25/144 (17%)
Query: 4 IMEPVSKWSPSQVVDWMKG-LDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGH 62
+ +PV+ W+ V W+K + Q Y ++F++ I+G LLR+T ++LE +G+++
Sbjct: 70 LSKPVALWTQQDVCKWLKKHCPNQYQIYSESFKQHDITGRALLRLTDKKLERMGIAQENL 129
Query: 63 QELILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGR--RRSGHYDGRTSRKL 120
++ IL+ V L K+ +NLQ G G DG RK
Sbjct: 130 RQHILQQV-----------------LQLKVREEVRNLQLLTQGTLLLPDGWMDGEIRRK- 171
Query: 121 PNDFLTSVVDLIGAAKSLLAWLDR 144
T ++ G ++LL +L R
Sbjct: 172 ----TTLLLGQTGVRENLLLFLHR 191
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 44.3 bits (103), Expect = 6e-04
Identities = 32/116 (27%), Positives = 49/116 (42%), Gaps = 7/116 (6%)
Query: 572 DCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYINEEDEKAEGFISLPEFKIDRASEC 631
D EGWL K + WK+ WF+L D LY++ D++ G I L I +
Sbjct: 261 DREGWLLKLGGRV----KTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDP 316
Query: 632 RKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSES 687
RK F+ P K A + R + +M+ Y ++E+D W +S
Sbjct: 317 RKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMV---YRISAPTQEEKDEWIKS 369
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 44.3 bits (103), Expect = 6e-04
Identities = 35/131 (26%), Positives = 59/131 (45%), Gaps = 8/131 (6%)
Query: 222 KPSEGLGMYIKSTYD----GL--HVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQL 275
K +EG G I ++ + G+ H I E SPADRC K+ GD + VN Q++V
Sbjct: 857 KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916
Query: 276 KNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSS 335
N+V +++ +GV +TL + P+ + R P + +S + + S
Sbjct: 917 DNIVQLIKD--AGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRS 974
Query: 336 TISTPTKRDSS 346
+ +D S
Sbjct: 975 ALEGEIGKDVS 985
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 44.3 bits (103), Expect = 6e-04
Identities = 35/131 (26%), Positives = 59/131 (45%), Gaps = 8/131 (6%)
Query: 222 KPSEGLGMYIKSTYD----GL--HVITGTTENSPADRCKKIHAGDEVIQVNHQTVVGWQL 275
K +EG G I ++ + G+ H I E SPADRC K+ GD + VN Q++V
Sbjct: 857 KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916
Query: 276 KNLVNALREDPSGVILTLKKRPQSMLTSAPALLKNMRWKPLALQPLIPRSPTSSVATPSS 335
N+V +++ +GV +TL + P+ + R P + +S + + S
Sbjct: 917 DNIVQLIKD--AGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRS 974
Query: 336 TISTPTKRDSS 346
+ +D S
Sbjct: 975 ALEGEIGKDVS 985
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 44.3 bits (103), Expect = 6e-04
Identities = 31/119 (26%), Positives = 58/119 (48%), Gaps = 22/119 (18%)
Query: 22 GLDDCLQQYIKN---------FEREKISGDQLLRITHQELEDLGVSRIGHQELILEAVDL 72
G+D + Q+++N FERE+I+ D L+ + H+EL+++G++ GH+ +++ V+
Sbjct: 873 GVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVER 932
Query: 73 LCALNYG------LETENLKTLSHKLNASAK-------NLQNFITGRRRSGHYDGRTSR 118
L + G L T T+ L+ K +Q+ + R GH G +R
Sbjct: 933 LISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNR 991
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,432,489
Number of Sequences: 37866
Number of extensions: 2224481
Number of successful extensions: 20537
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 299
Number of HSP's successfully gapped in prelim test: 264
Number of HSP's that attempted gapping in prelim test: 15227
Number of HSP's gapped (non-prelim): 3610
length of query: 1034
length of database: 18,247,518
effective HSP length: 112
effective length of query: 922
effective length of database: 14,006,526
effective search space: 12914016972
effective search space used: 12914016972
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.