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Search of human proteins with 41349446
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41349446 stromal interaction molecule 2 [Homo sapiens]
(833 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41349446 stromal interaction molecule 2 [Homo sapiens] 1689 0.0
gi|21070997 stromal interaction molecule 1 precursor [Homo sapiens] 574 e-163
gi|194353964 coiled-coil domain containing 157 [Homo sapiens] 50 7e-06
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 50 9e-06
gi|216548091 leucine zipper protein 1 [Homo sapiens] 49 2e-05
gi|216548085 leucine zipper protein 1 [Homo sapiens] 49 2e-05
gi|59806361 hypothetical protein LOC387104 [Homo sapiens] 48 4e-05
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 48 4e-05
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 47 1e-04
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 47 1e-04
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 47 1e-04
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 46 1e-04
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 46 2e-04
gi|167614504 laminin, beta 1 precursor [Homo sapiens] 45 3e-04
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 45 3e-04
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 45 3e-04
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 45 3e-04
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 45 3e-04
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 45 3e-04
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 45 3e-04
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 45 3e-04
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 45 3e-04
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 44 6e-04
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 44 6e-04
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 44 6e-04
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 44 6e-04
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 44 6e-04
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 44 8e-04
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 44 8e-04
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 43 0.001
>gi|41349446 stromal interaction molecule 2 [Homo sapiens]
Length = 833
Score = 1689 bits (4373), Expect = 0.0
Identities = 833/833 (100%), Positives = 833/833 (100%)
Query: 1 MNAAGIRAPEAAGADGTRLAPGGSPCLRRRGRPEESPAAVVAPRGAGELQAAGAPLRFHP 60
MNAAGIRAPEAAGADGTRLAPGGSPCLRRRGRPEESPAAVVAPRGAGELQAAGAPLRFHP
Sbjct: 1 MNAAGIRAPEAAGADGTRLAPGGSPCLRRRGRPEESPAAVVAPRGAGELQAAGAPLRFHP 60
Query: 61 ASPRRLHPASTPGPAWGWLLRRRRWAALLVLGLLVAGAADGCELVPRHLRGRRATGSAAT 120
ASPRRLHPASTPGPAWGWLLRRRRWAALLVLGLLVAGAADGCELVPRHLRGRRATGSAAT
Sbjct: 61 ASPRRLHPASTPGPAWGWLLRRRRWAALLVLGLLVAGAADGCELVPRHLRGRRATGSAAT 120
Query: 121 AASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVEESD 180
AASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVEESD
Sbjct: 121 AASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLEALQTIHKQMDDDKDGGIEVEESD 180
Query: 181 EFIREDMKYKDATNKHSHLHREDKHITIEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQ 240
EFIREDMKYKDATNKHSHLHREDKHITIEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQ
Sbjct: 181 EFIREDMKYKDATNKHSHLHREDKHITIEDLWKRWKTSEVHNWTLEDTLQWLIEFVELPQ 240
Query: 241 YEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHN 300
YEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHN
Sbjct: 241 YEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALDVVLFGPLTRPPHN 300
Query: 301 WMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQ 360
WMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQ
Sbjct: 301 WMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQ 360
Query: 361 EENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALK 420
EENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALK
Sbjct: 361 EENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALK 420
Query: 421 KAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRST 480
KAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRST
Sbjct: 421 KAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRST 480
Query: 481 VFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPS 540
VFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPS
Sbjct: 481 VFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPS 540
Query: 541 LTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVSQFPGTMAKPPGSLARSSSLC 600
LTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVSQFPGTMAKPPGSLARSSSLC
Sbjct: 541 LTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDEDTPPIVSQFPGTMAKPPGSLARSSSLC 600
Query: 601 RSRRSIVPSSPQPQRAQLAPHAPHPSHPRHPHHPQHTPHSLPSPDPDILSVSSCPALYRN 660
RSRRSIVPSSPQPQRAQLAPHAPHPSHPRHPHHPQHTPHSLPSPDPDILSVSSCPALYRN
Sbjct: 601 RSRRSIVPSSPQPQRAQLAPHAPHPSHPRHPHHPQHTPHSLPSPDPDILSVSSCPALYRN 660
Query: 661 EEEEEAIYFSAEKQWEVPDTASECDSLNSSIGRKQSPPLSLEIYQTLSPRKISRDEVSLE 720
EEEEEAIYFSAEKQWEVPDTASECDSLNSSIGRKQSPPLSLEIYQTLSPRKISRDEVSLE
Sbjct: 661 EEEEEAIYFSAEKQWEVPDTASECDSLNSSIGRKQSPPLSLEIYQTLSPRKISRDEVSLE 720
Query: 721 DSSRGDSPVTVDVSWGSPDCVGLTETKSMIFSPASKVYNGILEKSCSMNQLSSGIPVPKP 780
DSSRGDSPVTVDVSWGSPDCVGLTETKSMIFSPASKVYNGILEKSCSMNQLSSGIPVPKP
Sbjct: 721 DSSRGDSPVTVDVSWGSPDCVGLTETKSMIFSPASKVYNGILEKSCSMNQLSSGIPVPKP 780
Query: 781 RHTSCSSAGNDSKPVQEAPSVARISSIPHDLCHNGEKSKKPSKIKSLFKKKSK 833
RHTSCSSAGNDSKPVQEAPSVARISSIPHDLCHNGEKSKKPSKIKSLFKKKSK
Sbjct: 781 RHTSCSSAGNDSKPVQEAPSVARISSIPHDLCHNGEKSKKPSKIKSLFKKKSK 833
>gi|21070997 stromal interaction molecule 1 precursor [Homo sapiens]
Length = 685
Score = 574 bits (1480), Expect = e-163
Identities = 322/659 (48%), Positives = 405/659 (61%), Gaps = 77/659 (11%)
Query: 108 HLRGRRATGSAATAASSPAAAAGDSPALMTDPCMSLSPPCFTEEDRFSLEALQTIHKQMD 167
H +ATG+++ A S + AA + C P C +E+++ S EA++ IHK MD
Sbjct: 25 HSHSEKATGTSSGANSEESTAA--------EFCRIDKPLCHSEDEKLSFEAVRNIHKLMD 76
Query: 168 DDKDGGIEVEESDEFIREDMKYKDATNKHSHLHREDKHITIEDLWKRWKTSEVHNWTLED 227
DD +G ++VEESDEF+RED+ Y D T KHS H EDK I++EDLWK WK+SEV+NWT+++
Sbjct: 77 DDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDE 136
Query: 228 TLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEPSFMISQLKISDRSHRQKLQLKALD 287
+QWLI +VELPQYE+ FR + G +PR+AV + + LK++DRSHRQKLQLKALD
Sbjct: 137 VVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALD 196
Query: 288 VVLFGPLTRPPHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLESLQTAEQ 347
VLFGP HN +KDF+L VSIVIGVGGCWFAY QN+ SKEH+ KMMKDLE L AEQ
Sbjct: 197 TVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQ 256
Query: 348 SLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRRQY 407
SL DLQERL KAQEE+R V VEK +LE+K+ DEIN AK+EA RL+ELREG E E SR++Y
Sbjct: 257 SLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKY 316
Query: 408 AEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIA 467
AE+ELEQVR AL+KAEKE E SSW P+ALQKWLQLTHEVEVQYYNIK+QNAE QL +A
Sbjct: 317 AEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVA 376
Query: 468 KDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKI 527
K+ AEKIKKKR+T+FGT HVAHSSSLD+VDHKIL AK+ALSE+T LRERL RWQQIE +
Sbjct: 377 KEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEIL 436
Query: 528 CGFQIAHNSGLPSLTSSLYSDHSWVVMPRVSIPPYPIAGGVDDLDED--------TPPIV 579
CGFQI +N G+ SL ++L D SW+ R + + + VDD+DE+ +P +
Sbjct: 437 CGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQ 496
Query: 580 SQFPGTMAKPPGSLARSSSLCRS----------RRSIVPSSPQPQRA------------- 616
S + +P L L S R+ + P PQ RA
Sbjct: 497 SSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSDRQRVAPKPPQMSRAADEALNAMTSNGS 556
Query: 617 -------------QLAPHAP-----------------------HPSHP--RHPHHPQHTP 638
+ P +P PS P PH
Sbjct: 557 HRLIEGVHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSPSAPPGGSPHLDSSRS 616
Query: 639 HSLPSPDPDILSVSSCPALYRNEEEEEAIYFSAEKQWEVPDTASECDSLNSSIGRKQSP 697
HS SPDPD S + + + +K D S + +SS GRK+ P
Sbjct: 617 HSPSSPDPDTPSPVGDSRALQASRNTRIPHLAGKKAVAEEDNGSIGEETDSSPGRKKFP 675
>gi|194353964 coiled-coil domain containing 157 [Homo sapiens]
Length = 752
Score = 50.4 bits (119), Expect = 7e-06
Identities = 73/333 (21%), Positives = 126/333 (37%), Gaps = 57/333 (17%)
Query: 318 CWFAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKM 377
CW A T+ K V M++ ESLQ +++L+ + L++ +EE R E + ++
Sbjct: 424 CW-ASTELDKEKARVDSMVRHQESLQAKQRALLKQLDSLDQEREELRGSLDEAEAQRARV 482
Query: 378 MDEINYAKEEA-CRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPD 436
+++ +E+ C+LR +E + +Q EQ +R+ + + E+E E
Sbjct: 483 EEQLQSEREQGQCQLRAQQELLQSLQREKQGLEQATTDLRLTILELERELEELKERE--R 540
Query: 437 ALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEV 496
L + L E Q + + + E Q+ D T H+ +++
Sbjct: 541 LLVAFPDLHRPTETQIHGGRSSSVESQITCPTDSGNV----------TDHMERQVQANDI 590
Query: 497 DHKILEAKKA-LSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYSDHSWVVMP 555
++L+ + L + + +RE +A GL + D W
Sbjct: 591 RIRVLQEENGRLQSMLSKIRE---------------VAQQGGLKLIP----QDRLW---- 627
Query: 556 RVSIPPYPIAGGVDDLDEDTPPIVSQFPGTMAKPPGSLAR----SSSLCRSRRSIVPSSP 611
P + G TPP+ ++ + PG L R SS R+ +SP
Sbjct: 628 ------SPSSKGTQGA---TPPVQAK-----STSPGPLGRQHLPSSRTGRTLLGQPCTSP 673
Query: 612 QPQRAQLAPHAPHPSHPRHP-HHPQHTPHSLPS 643
Q P P S PR P P P S PS
Sbjct: 674 PRQPCTSPPRQPCTSPPRQPCTSPSRQPCSQPS 706
Score = 32.3 bits (72), Expect = 1.9
Identities = 44/208 (21%), Positives = 85/208 (40%), Gaps = 14/208 (6%)
Query: 317 GCWFAYTQNKTSK--EHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLE 374
G W A + ++ +HV + LE + + L +LE+A ++ + + +
Sbjct: 273 GRWAAEQRKDLTRLSKHVEALRAQLEEAEGQKDGLRKQAGKLEQALKQEQGARRRQAEED 332
Query: 375 RKMMDEINYAKE----EACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRS 430
+ + E + K+ E L+ E EL +++ + Q +E L++ E E +
Sbjct: 333 EQCLSEWEHDKQQLLTETSDLKTKMATLERELKQQRESTQAVEAKAQQLQE-EGERRAAA 391
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHS 490
V ++ QL E +VQ + + A Q+ A E +K K + ++ V H
Sbjct: 392 ERQVQQLEEQVQQL--EAQVQLLVGRLEGAGQQVCWASTELDKEKARVDSM-----VRHQ 444
Query: 491 SSLDEVDHKILEAKKALSELTTCLRERL 518
SL +L+ +L + LR L
Sbjct: 445 ESLQAKQRALLKQLDSLDQEREELRGSL 472
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 50.1 bits (118), Expect = 9e-06
Identities = 53/219 (24%), Positives = 99/219 (45%), Gaps = 24/219 (10%)
Query: 324 QNKTSKEHVAKMMKDLESLQTAEQSLMDLQERL----------EKAQEENRNVAVEK-QN 372
Q + E KM + E + E+ + +L+E++ EK QEE + EK Q
Sbjct: 415 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 474
Query: 373 LERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSW 432
E KM + +E+ ++RE E ++ R++ E E++R K+ E+E R
Sbjct: 475 QEAKMWRQEEKIREQEEKIREQEE----KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 530
Query: 433 SVPDALQKWLQLTHEVEVQYYNIKRQNAEM--QLAIAKDEAEKIKKKRSTVFGTLHVAHS 490
+ + + W Q ++ Q I++Q +M Q D+ EKI+++ V+
Sbjct: 531 KIREQEEIWRQ-KEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVW-----RQE 584
Query: 491 SSLDEVDHKILEAKKALSELTTCLRERLFRW-QQIEKIC 528
+ E + KI E ++ + E +E+ + +Q EK+C
Sbjct: 585 EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMC 623
Score = 35.8 bits (81), Expect = 0.17
Identities = 34/155 (21%), Positives = 73/155 (47%), Gaps = 19/155 (12%)
Query: 324 QNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINY 383
Q + +E K+ + E ++ E+ + + +E++ + +E + EK+ R+ +E+ +
Sbjct: 380 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE----MMWEKEEKMRRQ-EEMMW 434
Query: 384 AKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQ 443
KEE R E + + ++ ++ QE E++R K+ E+E ++ W Q
Sbjct: 435 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM------------WRQ 482
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAK-DEAEKIKKK 477
++ Q I+ Q +M K E EKI+++
Sbjct: 483 -EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREE 516
Score = 33.9 bits (76), Expect = 0.64
Identities = 44/225 (19%), Positives = 99/225 (44%), Gaps = 25/225 (11%)
Query: 323 TQNKTSKEHVAKMMKDLE--SLQTAEQSLMD---------LQERLEKAQEENRNVAVEKQ 371
TQ K + ++ ++ K+ + SL+ ++ D LQE+L+ + E + + +
Sbjct: 247 TQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVK 306
Query: 372 NLERKMMDEINYAKEEACRLRELREGAECE-LSRRQYAEQELEQVRMALKKAEKEFELRS 430
L+RK+ ++ + G E + +S + A+ E ++ L + ++E
Sbjct: 307 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE----K 362
Query: 431 SWSVPDALQKWLQLTHE----VEVQYYNIKRQNAEM--QLAIAKDEAEKIKKKRSTVFGT 484
W + +Q+W + E + Q I+ Q +M Q + ++ EK++++ ++
Sbjct: 363 MWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 422
Query: 485 LHV--AHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKI 527
+ E + KI E ++ + E +RE+ + Q+ EKI
Sbjct: 423 EEKMRRQEEMMWEKEEKIRELEEKMHEQEK-IREQEEKRQEEEKI 466
>gi|216548091 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 48.9 bits (115), Expect = 2e-05
Identities = 53/194 (27%), Positives = 92/194 (47%), Gaps = 25/194 (12%)
Query: 340 ESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMM-----DEINYAKEEACRLREL 394
++LQ AE L+DLQ+++ +A+ N ++ E + L ++++ DE E+ CRL +
Sbjct: 35 KNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKE 94
Query: 395 REGAECELSRRQYAEQELEQVRMA-LKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYY 453
+ E L+R +E E Q RMA L+K E+ F S S D Q L L E +
Sbjct: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAF----SRSKNDCTQLCLSLNEERNL--- 147
Query: 454 NIKRQNAEMQLAIAK-----DEAEKIKKKRSTVFGTLHVAHSSSLDEV------DHKILE 502
K+ ++E+++ K +++ K ++ L S +L V + K E
Sbjct: 148 -TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE 206
Query: 503 AKKALSELTTCLRE 516
+K + ELT L +
Sbjct: 207 NEKLIKELTQKLEQ 220
>gi|216548085 leucine zipper protein 1 [Homo sapiens]
Length = 1076
Score = 48.9 bits (115), Expect = 2e-05
Identities = 53/194 (27%), Positives = 92/194 (47%), Gaps = 25/194 (12%)
Query: 340 ESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMM-----DEINYAKEEACRLREL 394
++LQ AE L+DLQ+++ +A+ N ++ E + L ++++ DE E+ CRL +
Sbjct: 35 KNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLRIEGKDEEIKRAEDLCRLMKE 94
Query: 395 REGAECELSRRQYAEQELEQVRMA-LKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYY 453
+ E L+R +E E Q RMA L+K E+ F S S D Q L L E +
Sbjct: 95 KLEEEENLTRELKSEIERLQKRMAELEKLEEAF----SRSKNDCTQLCLSLNEERNL--- 147
Query: 454 NIKRQNAEMQLAIAK-----DEAEKIKKKRSTVFGTLHVAHSSSLDEV------DHKILE 502
K+ ++E+++ K +++ K ++ L S +L V + K E
Sbjct: 148 -TKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLKSLTLSFVSERKYLNEKEKE 206
Query: 503 AKKALSELTTCLRE 516
+K + ELT L +
Sbjct: 207 NEKLIKELTQKLEQ 220
>gi|59806361 hypothetical protein LOC387104 [Homo sapiens]
Length = 947
Score = 47.8 bits (112), Expect = 4e-05
Identities = 39/138 (28%), Positives = 76/138 (55%), Gaps = 16/138 (11%)
Query: 347 QSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEI--NYAKEEACRLRELREGAE----- 399
Q ++QE +EK +EEN + E L R MDE+ + +E+AC+L+E+R E
Sbjct: 347 QEQEEMQEEMEKLREENETLKNEIDEL-RTEMDEMRDTFFEEDACQLQEMRHELERANKN 405
Query: 400 CELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQN 459
C + + + + E +++R A + E + EL S L++ L++ +V V+ ++ + +N
Sbjct: 406 CRILQYRLRKAERKRLRYA-QTGEIDGELLRS------LEQDLKVAKDVSVRLHH-ELEN 457
Query: 460 AEMQLAIAKDEAEKIKKK 477
E + +DE EK++++
Sbjct: 458 VEEKRTTTEDENEKLRQQ 475
Score = 34.3 bits (77), Expect = 0.49
Identities = 40/195 (20%), Positives = 77/195 (39%), Gaps = 47/195 (24%)
Query: 324 QNKTSKEHVAKMMKDLESLQTA--EQSLMDLQERLEKAQEENRNVAVEKQNLE------- 374
+N+T K + ++ +++ ++ E+ LQE + + N+N + + L
Sbjct: 362 ENETLKNEIDELRTEMDEMRDTFFEEDACQLQEMRHELERANKNCRILQYRLRKAERKRL 421
Query: 375 -------------RKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKK 421
R + ++ AK+ + RL E E +R E E E++R L +
Sbjct: 422 RYAQTGEIDGELLRSLEQDLKVAKDVSVRLHHELENVE---EKRTTTEDENEKLRQQLIE 478
Query: 422 AE-------------KEFEL--RSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAI 466
E KE L R S +P + +K Q E + ++ + QL
Sbjct: 479 VEIAKQALQNELEKMKELSLKRRGSKDLPKSEKKAQQTPTEED-------NEDLKCQLQF 531
Query: 467 AKDEAEKIKKKRSTV 481
K+EA ++KK + +
Sbjct: 532 VKEEAALMRKKMAKI 546
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 47.8 bits (112), Expect = 4e-05
Identities = 42/209 (20%), Positives = 93/209 (44%), Gaps = 18/209 (8%)
Query: 325 NKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKM--MDEIN 382
N+ +++ KM + E +Q E+ + + +E++ + +E+ R E KM +E+
Sbjct: 280 NRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 339
Query: 383 YAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWL 442
+ KEE R E + + ++ ++ QE E++R K+ E+E ++ W + +++
Sbjct: 340 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM---WRQEEKIREQE 396
Query: 443 QLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILE 502
+ E E + + E + + + E E +++ + + KI E
Sbjct: 397 EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQE-------------EKMRRQEEKIRE 443
Query: 503 AKKALSELTTCLRERLFRWQQIEKICGFQ 531
+K + E +RE+ Q+ E+ G Q
Sbjct: 444 QEKKIREQEEKIREQEEMMQEQEEKMGEQ 472
Score = 36.6 bits (83), Expect = 0.099
Identities = 36/202 (17%), Positives = 87/202 (43%), Gaps = 18/202 (8%)
Query: 322 YTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEI 381
+ Q + +E K+ + E +Q E+ + + +E++ + +EE + + + E K+ ++
Sbjct: 386 WRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE 445
Query: 382 NYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKW 441
+E+ ++RE E + + EQE + K E+E ++R +K
Sbjct: 446 KKIREQEEKIREQEE--MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQ------EEKI 497
Query: 442 LQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKIL 501
+ ++ Q I+ Q MQ ++ EK+ ++ + + E + K+
Sbjct: 498 REQEKKIREQEEKIREQEEMMQ-----EQEEKMWEQEEKM-----CEQEEKMQEQEEKMR 547
Query: 502 EAKKALSELTTCLRERLFRWQQ 523
++ + E LR++ + Q+
Sbjct: 548 RQEEKMREQEVRLRQQEEKMQE 569
Score = 33.1 bits (74), Expect = 1.1
Identities = 40/217 (18%), Positives = 95/217 (43%), Gaps = 30/217 (13%)
Query: 323 TQNKTSKEHVAKMMKDLE--SLQTAEQSLMD---------LQERLEKAQEENRNVAVEKQ 371
TQ K + ++ ++ K+ + SL+ ++ D LQE+L+ + E + + +
Sbjct: 174 TQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVK 233
Query: 372 NLERKMMDEINYAKEEACRLRELREGAECE-LSRRQYAEQELEQVRMALKKAEKEFELRS 430
L+RK+ ++ + G E + +S + A+ E ++ L + ++E R
Sbjct: 234 ELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQ 293
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHS 490
+ + +K + ++ Q ++RQ M ++ EK++++ ++
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRRQEEMMW-----EKEEKMRRQEEMMW-----EKE 343
Query: 491 SSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKI 527
+ E++ K+ E +K +RE+ + Q+ EKI
Sbjct: 344 EKIRELEEKMHEQEK--------IREQEEKRQEEEKI 372
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 46.6 bits (109), Expect = 1e-04
Identities = 49/209 (23%), Positives = 94/209 (44%), Gaps = 11/209 (5%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVA---VEKQNLERKMMDEINYAK 385
+E +M + E ++ EQ + D +ER+EK +E EK E +M + +
Sbjct: 540 REQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMR 599
Query: 386 EEACRLRELREGAECELSRRQYAEQEL-EQVRMALKKAEKEFELRSS-WSVPDALQKWLQ 443
EE +RE E + + + Q E+++ EQ ++ EK +E W + + + +
Sbjct: 600 EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR 659
Query: 444 LTHEVEVQYYNIKRQNAE-MQLAIAKD-EAEKIKKK----RSTVFGTLHVAHSSSLDEVD 497
L + E + + K Q E MQ K E EK++KK + + S+ E +
Sbjct: 660 LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRERE 719
Query: 498 HKILEAKKALSELTTCLRERLFRWQQIEK 526
K+ E ++ + E ++E+ + Q+ E+
Sbjct: 720 KKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/151 (22%), Positives = 70/151 (46%), Gaps = 14/151 (9%)
Query: 336 MKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELR 395
M++ E +Q E+ + + QE++EK +E E+K D+ +EE+ R RE +
Sbjct: 673 MQEQEKMQEQEEKIWE-QEKMEKKTQEQ----------EKKTWDQEKMREEESMREREKK 721
Query: 396 EGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNI 455
E E+ R Q + + ++ +M ++ E + W + + + +L + E + +
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781
Query: 456 KRQNAEM---QLAIAKDEAEKIKKKRSTVFG 483
K Q E Q +D+ EK++ + + G
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRG 812
Score = 37.4 bits (85), Expect = 0.058
Identities = 48/244 (19%), Positives = 103/244 (42%), Gaps = 46/244 (18%)
Query: 323 TQNKTSKEHVAKMMKDLESL-----------QTAEQSLMDLQERLEKAQEENRNVAVEKQ 371
T++K + ++ ++ K+ ++L + ++ +LQE+L A+ E + + +
Sbjct: 190 TRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVK 249
Query: 372 NLERKM--------------MDEINYAKEEACRLRELREGAECELSRRQ----------Y 407
L+RK+ + E + +EE R +E + + E RQ
Sbjct: 250 ELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM 309
Query: 408 AEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEM--QLA 465
EQE + R + E+E ELR +K L+ E+ Q ++ Q +M Q
Sbjct: 310 REQEEKMWRQEKRLREQEKELREQ-------EKELREQKELREQEEQMQEQEEKMWEQEE 362
Query: 466 IAKDEAEKIKKKRSTVFGTLHV--AHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQ 523
+++ EK+ ++ ++ + + + ++ E + L E +RE+ W+Q
Sbjct: 363 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 422
Query: 524 IEKI 527
+EK+
Sbjct: 423 VEKM 426
Score = 37.4 bits (85), Expect = 0.058
Identities = 37/204 (18%), Positives = 87/204 (42%), Gaps = 22/204 (10%)
Query: 324 QNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINY 383
+ K +E +M + E + E+ + + +E++ + +E + + E+KM D+
Sbjct: 339 EQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398
Query: 384 AKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQ 443
E+ RLRE E + ++ +++E++R K E+E + R ++ +Q
Sbjct: 399 MWEQDERLREKEE----RMREQEKMWEQVEKMREEKKMQEQEKKTRDQ-------EEKMQ 447
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEA 503
+ + ++ + M +++ EK++K+ ++ + ++ E
Sbjct: 448 EEERIREREKKMREEEETM-----REQEEKMQKQEENMW------EQEEKEWQQQRLPEQ 496
Query: 504 KKALSELTTCLRERLFRWQQIEKI 527
K+ L E + W+Q EKI
Sbjct: 497 KEKLWEQEKMQEQEEKIWEQEEKI 520
Score = 37.0 bits (84), Expect = 0.076
Identities = 26/106 (24%), Positives = 48/106 (45%), Gaps = 2/106 (1%)
Query: 322 YTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEI 381
+ Q K +E KM E + ++ L + +ER+ ++E VEK E+KM ++
Sbjct: 379 WEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR--EQEKMWEQVEKMREEKKMQEQE 436
Query: 382 NYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFE 427
+++ +++E E E R+ E EQ K+ E +E
Sbjct: 437 KKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 482
Score = 35.4 bits (80), Expect = 0.22
Identities = 37/213 (17%), Positives = 91/213 (42%), Gaps = 10/213 (4%)
Query: 324 QNKTSKEHVAKMMKDL----ESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMD 379
Q T +E + + ++L + ++ E+ + +ERL + + + R + E+++ +
Sbjct: 266 QTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLRE 325
Query: 380 EINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSS-WSVPDAL 438
+ +E+ LRE +E E E ++ E+ EQ ++ EK + W +
Sbjct: 326 QEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 385
Query: 439 QKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDE-----AEKIKKKRSTVFGTLHVAHSSSL 493
++ Q + E + + + E + + + E EK+++++
Sbjct: 386 REQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK 445
Query: 494 DEVDHKILEAKKALSELTTCLRERLFRWQQIEK 526
+ + +I E +K + E +RE+ + Q+ E+
Sbjct: 446 MQEEERIREREKKMREEEETMREQEEKMQKQEE 478
Score = 33.1 bits (74), Expect = 1.1
Identities = 37/203 (18%), Positives = 88/203 (43%), Gaps = 13/203 (6%)
Query: 334 KMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRE 393
KM + +E ++ E+ M QE+ + QEE + E+KM +E +E+ ++++
Sbjct: 418 KMWEQVEKMR--EEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475
Query: 394 LREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSS-WSVPDALQKWLQLTHEVEVQY 452
E E +++ +Q L + + L + EK E W + ++ ++ + + +
Sbjct: 476 QEENM-WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMW 534
Query: 453 YNIKRQNAEMQL----AIAKDEAEKIKKKRSTVFGTLHVAHSSSLDE-----VDHKILEA 503
K + E Q+ +D+ +K+ + + + D+ + ++ E
Sbjct: 535 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER 594
Query: 504 KKALSELTTCLRERLFRWQQIEK 526
+K + E +RE+ + Q+ E+
Sbjct: 595 EKKMREEEEMMREQEEKMQEQEE 617
Score = 31.6 bits (70), Expect = 3.2
Identities = 40/221 (18%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 323 TQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKM----- 377
T+++ K + +++ E E+ M QE + QEEN EK+ ++++
Sbjct: 439 TRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 498
Query: 378 ----------MDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFE 427
+E + +EE R +E G E ++ R++ ++ +Q+ E+E +
Sbjct: 499 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQM------WEQEEK 552
Query: 428 LRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHV 487
+R D QK +E + +++ + + + ++E + ++K+ +
Sbjct: 553 MR------DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
Query: 488 AHSSSLDEVDHKILEAKKALSELTTCLRERLFR-WQQIEKI 527
+ E + K+ E ++ + E ++E+ + W+Q EK+
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKM 647
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 46.6 bits (109), Expect = 1e-04
Identities = 66/365 (18%), Positives = 145/365 (39%), Gaps = 38/365 (10%)
Query: 156 LEALQTIHKQMDDDKDGGIEVEES-DEFIREDMKYKDATNKHSHLHREDKHITIEDLWKR 214
L+ + Q+ + +G + EE D+ I+ ++ + + + +++ I E K+
Sbjct: 887 LKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK 946
Query: 215 WKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEP-SFMISQLKIS 273
K + + +D + ++ + EK+ +N VK T + E + + + K
Sbjct: 947 RKLEDECSELKKDIDDLELTLAKVEK-EKHATENKVKNLTEEMAGLDETIAKLTKEKKAL 1005
Query: 274 DRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVA 333
+H+Q L + LT+ + + V + Q K + +
Sbjct: 1006 QEAHQQTLDDLQAEEDKVNTLTKAK----------IKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 334 KMMKDLES-LQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE-------INYAK 385
+ + LE L+ A++S+MD++ ++ E+ + E NL+ K+ DE K
Sbjct: 1056 RAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIK 1115
Query: 386 EEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLT 445
E R+ EL E E E + R AE++ + L++ + E A +++
Sbjct: 1116 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE-----EAGGATSAQIEMN 1170
Query: 446 HEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKK 505
+ E ++ ++R + E+ + TL H+ S+ E+ +I ++
Sbjct: 1171 KKREAEFQKMRR------------DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 506 ALSEL 510
+L
Sbjct: 1219 VKQKL 1223
Score = 40.0 bits (92), Expect = 0.009
Identities = 41/182 (22%), Positives = 85/182 (46%), Gaps = 17/182 (9%)
Query: 330 EHVAKMMKDLESL-QTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
E V+K +LE + +T E L +L+ + E+ Q ++ ++ L+ + E
Sbjct: 1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTE--------SGEF 1293
Query: 389 CRLRELREGAECELSR-RQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHE 447
R + +E +LSR +Q Q++E+++ L++ E+++ ++ ALQ
Sbjct: 1294 SRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE-----EIKAKNALAHALQSSRHDCDL 1348
Query: 448 VEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKAL 507
+ QY + AE+Q A++K E + + T + T + + L+E K+ + +A
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWR--TKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 508 SE 509
E
Sbjct: 1407 EE 1408
Score = 38.5 bits (88), Expect = 0.026
Identities = 44/203 (21%), Positives = 86/203 (42%), Gaps = 18/203 (8%)
Query: 341 SLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLE---RKMMDEINYAKEEACRLRELREG 397
S + AEQ L+D ER++ +N ++ K+ LE +M E+ +EA E +
Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763
Query: 398 AEC-------ELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDAL-------QKWLQ 443
A EL + Q LE+++ +++ K+ +LR + AL QK
Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSL-DEVDHKILE 502
E+E + + +++NAE + K E + T ++ L D++ K+
Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1883
Query: 503 AKKALSELTTCLRERLFRWQQIE 525
K+ E L ++++++
Sbjct: 1884 YKRQAEEAEEQSNTNLAKFRKLQ 1906
Score = 34.3 bits (77), Expect = 0.49
Identities = 37/174 (21%), Positives = 74/174 (42%), Gaps = 12/174 (6%)
Query: 346 EQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRR 405
++ + +LQ R+E+ +EE + E++ D +E + RL E ++
Sbjct: 1111 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1170
Query: 406 QYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR--QNAEMQ 463
+ E E +++R L++A + E ++ +K E+ Q N++R Q E +
Sbjct: 1171 KKREAEFQKMRRDLEEATLQHEATAA----TLRKKHADSVAELGEQIDNLQRVKQKLEKE 1226
Query: 464 LAIAKDEAEKIKKKRSTVF---GTLHV---AHSSSLDEVDHKILEAKKALSELT 511
+ K E + + TV G L L E+ K E ++ +++LT
Sbjct: 1227 KSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 46.6 bits (109), Expect = 1e-04
Identities = 66/365 (18%), Positives = 145/365 (39%), Gaps = 38/365 (10%)
Query: 156 LEALQTIHKQMDDDKDGGIEVEES-DEFIREDMKYKDATNKHSHLHREDKHITIEDLWKR 214
L+ + Q+ + +G + EE D+ I+ ++ + + + +++ I E K+
Sbjct: 887 LKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK 946
Query: 215 WKTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEP-SFMISQLKIS 273
K + + +D + ++ + EK+ +N VK T + E + + + K
Sbjct: 947 RKLEDECSELKKDIDDLELTLAKVEK-EKHATENKVKNLTEEMAGLDETIAKLTKEKKAL 1005
Query: 274 DRSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVA 333
+H+Q L + LT+ + + V + Q K + +
Sbjct: 1006 QEAHQQTLDDLQAEEDKVNTLTKAK----------IKLEQQVDDLEGSLEQEKKLRMDLE 1055
Query: 334 KMMKDLES-LQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE-------INYAK 385
+ + LE L+ A++S+MD++ ++ E+ + E NL+ K+ DE K
Sbjct: 1056 RAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIK 1115
Query: 386 EEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLT 445
E R+ EL E E E + R AE++ + L++ + E A +++
Sbjct: 1116 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE-----EAGGATSAQIEMN 1170
Query: 446 HEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKK 505
+ E ++ ++R + E+ + TL H+ S+ E+ +I ++
Sbjct: 1171 KKREAEFQKMRR------------DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQR 1218
Query: 506 ALSEL 510
+L
Sbjct: 1219 VKQKL 1223
Score = 40.0 bits (92), Expect = 0.009
Identities = 41/182 (22%), Positives = 85/182 (46%), Gaps = 17/182 (9%)
Query: 330 EHVAKMMKDLESL-QTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
E V+K +LE + +T E L +L+ + E+ Q ++ ++ L+ + E
Sbjct: 1242 ETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTE--------SGEF 1293
Query: 389 CRLRELREGAECELSR-RQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHE 447
R + +E +LSR +Q Q++E+++ L++ E+++ ++ ALQ
Sbjct: 1294 SRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE-----EIKAKNALAHALQSSRHDCDL 1348
Query: 448 VEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKAL 507
+ QY + AE+Q A++K E + + T + T + + L+E K+ + +A
Sbjct: 1349 LREQYEEEQESKAELQRALSKANTEVAQWR--TKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 508 SE 509
E
Sbjct: 1407 EE 1408
Score = 38.5 bits (88), Expect = 0.026
Identities = 44/203 (21%), Positives = 86/203 (42%), Gaps = 18/203 (8%)
Query: 341 SLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLE---RKMMDEINYAKEEACRLRELREG 397
S + AEQ L+D ER++ +N ++ K+ LE +M E+ +EA E +
Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763
Query: 398 AEC-------ELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDAL-------QKWLQ 443
A EL + Q LE+++ +++ K+ +LR + AL QK
Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSL-DEVDHKILE 502
E+E + + +++NAE + K E + T ++ L D++ K+
Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKS 1883
Query: 503 AKKALSELTTCLRERLFRWQQIE 525
K+ E L ++++++
Sbjct: 1884 YKRQAEEAEEQSNTNLAKFRKLQ 1906
Score = 34.3 bits (77), Expect = 0.49
Identities = 37/174 (21%), Positives = 74/174 (42%), Gaps = 12/174 (6%)
Query: 346 EQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRR 405
++ + +LQ R+E+ +EE + E++ D +E + RL E ++
Sbjct: 1111 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1170
Query: 406 QYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR--QNAEMQ 463
+ E E +++R L++A + E ++ +K E+ Q N++R Q E +
Sbjct: 1171 KKREAEFQKMRRDLEEATLQHEATAA----TLRKKHADSVAELGEQIDNLQRVKQKLEKE 1226
Query: 464 LAIAKDEAEKIKKKRSTVF---GTLHV---AHSSSLDEVDHKILEAKKALSELT 511
+ K E + + TV G L L E+ K E ++ +++LT
Sbjct: 1227 KSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 46.2 bits (108), Expect = 1e-04
Identities = 59/237 (24%), Positives = 95/237 (40%), Gaps = 53/237 (22%)
Query: 326 KTSKEHVAKMMKDLES------------LQTAEQSLMD-LQERLEKAQEENRNVAVEKQN 372
K+S+E +AK+ K E LQT E+ + ++ LEK+Q E ++ EK+
Sbjct: 472 KSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQ 531
Query: 373 LERKMMDEINYAK-----EEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEF- 426
E ++E+ K E +LR+L++ AE +R E LE+ K K+
Sbjct: 532 QESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA 591
Query: 427 -----------------------ELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQ 463
EL S DAL W + ++ QY EM+
Sbjct: 592 VHLEAEKNKHNKEITVMVEKHKTELESLKHQQDAL--WTEKLQVLKQQY------QTEME 643
Query: 464 LAIAKDEAEK---IKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRER 517
K E EK +K K + + +L+++D K E + SEL+ L+ R
Sbjct: 644 KLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR 700
Score = 37.4 bits (85), Expect = 0.058
Identities = 52/229 (22%), Positives = 98/229 (42%), Gaps = 38/229 (16%)
Query: 324 QNKTSKEHVAKMMKDLES-LQTAEQSLMDLQERLEKAQEENRNVAVE----------KQN 372
Q K ++DL+ +T +++L+ LEK+ +EN+N + + K N
Sbjct: 543 QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 602
Query: 373 LERKMMDEINYAKEEACR----------LRELREGAECELSR-RQYAEQELEQVRMALKK 421
E +M E + + E+ + L+ L++ + E+ + R+ EQE E + LK
Sbjct: 603 KEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETL---LKD 659
Query: 422 AEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIK-----RQNAEMQLAIAKDEAEKIKK 476
E F+ L+K E+E + R E +L++ KD+ +K+K+
Sbjct: 660 KEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ 719
Query: 477 KRSTVFGTLHVAHSSSLDEV--DHK--ILEAKKAL----SELTTCLRER 517
+ H +D + +H+ I +KAL ++L L+ER
Sbjct: 720 ELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Score = 37.0 bits (84), Expect = 0.076
Identities = 32/118 (27%), Positives = 61/118 (51%), Gaps = 15/118 (12%)
Query: 324 QNKTSKEHVAKMMKDLESLQTAEQSLMDL------QERLEKAQEENRNVAVEKQNLERKM 377
+ K KE + ++ KDL L+ Q +++ QER EK ++E ++ ++ + +++
Sbjct: 1939 KQKLGKE-IVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQL 1997
Query: 378 MDEINYAKEEACRLRELREGAECELSRRQYAEQEL-----EQVRMALKK-AEKEFELR 429
M E N + A + +EL + +++ Q E EL E+ LKK AEK+ +L+
Sbjct: 1998 MREFN--TQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLK 2053
Score = 33.5 bits (75), Expect = 0.84
Identities = 37/187 (19%), Positives = 83/187 (44%), Gaps = 21/187 (11%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
++H+ + ++ESL L+ ++ E++ + + Q+ + ++ N KE
Sbjct: 1531 EDHITQKTIEIESLNEV------LKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAE 1584
Query: 389 CRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEV 448
++ L + + ++ELE V +++K E+E + ++ K +L +
Sbjct: 1585 EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA 1644
Query: 449 EVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALS 508
E + IK+Q L+ +++ E+ KK GT S L E++ K+ E ++ +
Sbjct: 1645 EQKIAAIKKQ----LLSQMEEKEEQYKK------GT-----ESHLSELNTKLQEREREVH 1689
Query: 509 ELTTCLR 515
L L+
Sbjct: 1690 ILEEKLK 1696
Score = 30.8 bits (68), Expect = 5.4
Identities = 40/210 (19%), Positives = 87/210 (41%), Gaps = 24/210 (11%)
Query: 323 TQNKTSKEHVAKMMKDLESLQTA-EQSLMDLQERLE-------KAQEENRNVAVEKQNL- 373
T+ K V +M+ LE + EQ + L + E K QE+ + + VEK+N+
Sbjct: 854 TELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI 913
Query: 374 ---------ERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEK 424
E +++ + AKE++ + L E E + ++ ++++Q +++ K
Sbjct: 914 LQMREGQKKEIEILTQKLSAKEDSIHI--LNEEYETKFKNQEKKMEKVKQKAKEMQETLK 971
Query: 425 EFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGT 484
+ L + L+ + E Q+ + A+ A D +++ + +
Sbjct: 972 KKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIES 1031
Query: 485 LHVAHSSSLDEV----DHKILEAKKALSEL 510
L H L++V + K+ + + L E+
Sbjct: 1032 LTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
Score = 30.0 bits (66), Expect = 9.2
Identities = 37/166 (22%), Positives = 69/166 (41%), Gaps = 26/166 (15%)
Query: 329 KEHVAKMMKDLE----SLQTAEQSLMDLQERLE----------KAQEENRNVAVEKQNLE 374
K + K+LE S+++ E+ L L++RLE K + E + A++KQ L
Sbjct: 1598 KAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLS 1657
Query: 375 RKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSV 434
+ E Y K L EL ++ Q E+E+ + LK E + V
Sbjct: 1658 QMEEKEEQYKKGTESHLSELN-------TKLQEREREVHILEEKLKSVES--SQSETLIV 1708
Query: 435 PDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAK---DEAEKIKKK 477
P + + T + E ++ E ++++ + E EK+ ++
Sbjct: 1709 PRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQR 1754
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 45.8 bits (107), Expect = 2e-04
Identities = 53/201 (26%), Positives = 92/201 (45%), Gaps = 31/201 (15%)
Query: 343 QTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECEL 402
Q EQSL L+ERL+KA EE +E +EE+ RL LR A+ +
Sbjct: 638 QQKEQSLSSLRERLQKAIEE----------------EEARMREEESQRLSWLR--AQVQS 679
Query: 403 SRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEM 462
S + +Q + +L+K +E E + QK Q+ +++ + ++ +
Sbjct: 680 STQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLK-EEIEASEKSEQA 738
Query: 463 QLAIAKDEA-----EKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRER 517
L AK++A E+++ +R TL HS+ L+ + LEAK E+ + L+++
Sbjct: 739 ALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSS-LEAKH--REVVSSLQKK 795
Query: 518 LFRWQQIEKI----CGFQIAH 534
+ QQ E+ C Q+ H
Sbjct: 796 IQEAQQKEEAQLQKCLGQVEH 816
Score = 35.4 bits (80), Expect = 0.22
Identities = 46/198 (23%), Positives = 90/198 (45%), Gaps = 14/198 (7%)
Query: 324 QNKTSKEHVAKMMKDLESLQTAEQSLMDL--QERLEKAQEENRNVAVEKQNLERKMMDEI 381
+ K E + + +LE LQ A + ++ QE+ ++ ++ R +++ L+ +D
Sbjct: 873 ERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLE 932
Query: 382 NYAKEEACRLREL--------REGAECELSRRQYA--EQELEQVRMALKKAEKEFE--LR 429
AK+ RL L RE + +RQ A +E L++A+KE L+
Sbjct: 933 TRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQ 992
Query: 430 SSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAH 489
S+ + + L + ++E Q ++ Q+ ++Q + EAE KK+ T+ +
Sbjct: 993 SNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENN 1052
Query: 490 SSSLDEVDHKILEAKKAL 507
+S E D I + +K+L
Sbjct: 1053 ASPHFEPDLHIEDLRKSL 1070
>gi|167614504 laminin, beta 1 precursor [Homo sapiens]
Length = 1786
Score = 45.1 bits (105), Expect = 3e-04
Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 20/235 (8%)
Query: 282 QLKALDVVLFGPLTRPPHNWM-KDFILTVSIVIGVGGCWFAYTQNKTSKEHVAKMMKDLE 340
Q AL V+ LT H ++ K L +S VIG Y + S E +KD+
Sbjct: 1181 QCFALWDVIIAELTNRTHRFLEKAKALKISGVIG------PYRETVDSVERKVSEIKDIL 1234
Query: 341 SLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAEC 400
+ A + L ++ E+A++ ++V +E K+ D + + A L L+ AE
Sbjct: 1235 AQSPAAEPLKNIGNLFEEAEKLIKDVTEMMAQVEVKLSDTTSQSNSTAKELDSLQTEAES 1294
Query: 401 ELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVE--VQYYNIKRQ 458
+ + ++LE + K ++R + D++ K+ Q++ E E V +
Sbjct: 1295 LDNTVKELAEQLEFI--------KNSDIRGAL---DSITKYFQMSLEAEERVNASTTEPN 1343
Query: 459 NAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTC 513
+ Q A+ +D E + +R + F + LDE+ K+ + + TC
Sbjct: 1344 STVEQSALMRDRVEDVMMERESQFKEKQEEQARLLDELAGKLQSLDLSAAAEMTC 1398
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 17/180 (9%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AE L L+ R E+A+ + R E + L R++ DE ++ L R AE E +R
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAR 1529
Query: 405 -RQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQ-NAEM 462
+Q A Q LE++R+ ++AE+ Q ++ +V+V +R AE+
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLR-----------QAEVERARQVQVALETAQRSAEAEL 1578
Query: 463 QLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQ 522
Q A + + +RS HVA + +E + + + +A RE L RWQ
Sbjct: 1579 QSKRASFAEKTAQLERS--LQEEHVAVAQLREEAERRAQQQAEAERAREEAERE-LERWQ 1635
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/211 (24%), Positives = 98/211 (46%), Gaps = 21/211 (9%)
Query: 334 KMMKD-LESLQTAEQSLMD---LQERLEKAQEENRNVAVEKQNLERKMMDEINYAKE--E 387
KM+K+ ++++Q A + + LQ++ E AQE+ R + +K+ + +++ +E + E
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 388 ACRLRELREGAECELSRRQYAEQELEQVRMA------LKKAEKEFELRSSWSVPDALQKW 441
A R R+L AE E + + AE Q R K+AE+ E + A Q+
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEK 2427
Query: 442 LQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKIL 501
+ L +E+Q ++ AIA+ E EK K ++ L ++ + ++L
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLL 2485
Query: 502 EAKKA-----LSELTTCLRERLFRWQQIEKI 527
+ +A LSE + L+ F Q+ K+
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Score = 36.6 bits (83), Expect = 0.099
Identities = 39/148 (26%), Positives = 70/148 (47%), Gaps = 18/148 (12%)
Query: 339 LESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGA 398
L++ + A+Q + Q EK +EE A + E + + + A++E + R+L EG
Sbjct: 1646 LQAEEVAQQKSL-AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 399 ECELSRRQYAEQELEQVRMALKKAEKEFEL------RSSWSVPDALQKWLQLTHEVEVQY 452
+R AEQEL ++R ++ E++ +L R A QK +L E
Sbjct: 1705 ---AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----- 1756
Query: 453 YNIKRQNAEMQLAIAKDEAEKIKKKRST 480
+ + AEM++ +A +A ++ RST
Sbjct: 1757 --LAKVRAEMEVLLA-SKARAEEESRST 1781
Score = 36.2 bits (82), Expect = 0.13
Identities = 35/147 (23%), Positives = 70/147 (47%), Gaps = 21/147 (14%)
Query: 333 AKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAV-EKQNLERKMMDEINYAKEEACRL 391
+++ ++L S++ + L L+ R+E ENR + + +K N +R + +E K+ A
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2280
Query: 392 RELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQ 451
L A+ RQ AE++L Q R +K KE A+Q+ +L E E+
Sbjct: 2281 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE--------KMQAVQEATRLKAEAEL- 2331
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+ Q +A+++A ++++ +
Sbjct: 2332 --------LQQQKELAQEQARRLQEDK 2350
Score = 35.0 bits (79), Expect = 0.29
Identities = 48/198 (24%), Positives = 82/198 (41%), Gaps = 21/198 (10%)
Query: 321 AYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE 380
A + +EHVA E+ + A+Q Q E+A+EE +E+ L+
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQ-----QAEAERAREEAER-ELERWQLKANEALR 1643
Query: 381 INYAKEEACRLREL--------REGAECELSRRQYA-EQELEQVRMALKKAEKEFELRSS 431
+ EE + + L +E AE E RR A EQ + Q +A ++ EK+ +L
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703
Query: 432 WSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSS 491
+ + + E + +RQ E +LA + EA +KR + L +
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA- 1762
Query: 492 SLDEVDHKILEAKKALSE 509
+ ++L A KA +E
Sbjct: 1763 -----EMEVLLASKARAE 1775
Score = 33.9 bits (76), Expect = 0.64
Identities = 52/233 (22%), Positives = 101/233 (43%), Gaps = 26/233 (11%)
Query: 339 LESLQTAEQS--LMDLQERLEKAQ-------EENRNVAVEKQNLERKMMDEINYAKEEAC 389
L Q AE+ L +++ LEK + + E + L+++M +E+ +E A
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 390 RLRELREGAECELSR-RQYAEQELEQVRMALKKAEK-----EFELRSSWSVPDALQKWLQ 443
++ + + EL + RQ +E E++ + AE+ E E+R +A ++ +
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER-QR 1468
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKI---------KKKRSTVFGTLHVAHSSSLD 494
E E+Q + + AE Q A++EAE++ +K+++ V V +
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 495 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYS 547
+ L+A + L L ER R ++E+ Q+A + S + L S
Sbjct: 1529 REKQRALQALEEL-RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Score = 33.9 bits (76), Expect = 0.64
Identities = 43/168 (25%), Positives = 79/168 (47%), Gaps = 26/168 (15%)
Query: 330 EHVAKMMKDLESLQTAEQSLMDLQE----------RLEKAQ-EENRNVAVEKQNLERKMM 378
E +++ + E+ + +++L L+E RL +A+ E R V V + +R
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 379 DEI-----NYAKEEACRLRELREGAECELSRRQYAEQELEQ---VRMALKKAEKEFELRS 430
E+ ++A++ A R L+E R+ AE+ +Q A ++AE+E E R
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RW 1634
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+AL+ L+L E Q ++ + AE Q K+EAE+ ++R
Sbjct: 1635 QLKANEALR--LRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR 1676
Score = 33.5 bits (75), Expect = 0.84
Identities = 27/138 (19%), Positives = 61/138 (44%), Gaps = 6/138 (4%)
Query: 338 DLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREG 397
+ E+ + A + + + + E+ ++R E + L++ ++ + +LR+
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 398 AECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR 457
AE E +RR AEQ + + A A+ E E ++ QK E E+ ++
Sbjct: 2142 AEQEAARRAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---AQVEQELTTLRLQL 2195
Query: 458 QNAEMQLAIAKDEAEKIK 475
+ + Q + +E +++K
Sbjct: 2196 EETDHQKNLLDEELQRLK 2213
Score = 32.7 bits (73), Expect = 1.4
Identities = 32/141 (22%), Positives = 62/141 (43%), Gaps = 10/141 (7%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AEQ L+ L+ E+ +++ + + E L+R+ +E L ++R E L+
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 405 RQYAEQELEQVRMALKKAEKEFELRSS--WSVPDALQKWLQLTHEVEVQYYNIKRQNAEM 462
+ AE E+ R +K+++ E + + + + L E + Q RQ AE
Sbjct: 1771 KARAE---EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-----RQLAEE 1822
Query: 463 QLAIAKDEAEKIKKKRSTVFG 483
A + EAE++ ++ G
Sbjct: 1823 DAARQRAEAERVLAEKLAAIG 1843
Score = 30.0 bits (66), Expect = 9.2
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 2/96 (2%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
++ VAK + E Q +Q + ++RL + EE R E + R+ +E+ +++
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 389 CRLRELREGAECELSRRQYAEQELEQVRMALKKAEK 424
+ EL AE R+ + EQ R AL +E+
Sbjct: 2581 RQQEELL--AEENQRLREQLQLLEEQHRAALAHSEE 2614
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 17/180 (9%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AE L L+ R E+A+ + R E + L R++ DE ++ L R AE E +R
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAR 1533
Query: 405 -RQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQ-NAEM 462
+Q A Q LE++R+ ++AE+ Q ++ +V+V +R AE+
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLR-----------QAEVERARQVQVALETAQRSAEAEL 1582
Query: 463 QLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQ 522
Q A + + +RS HVA + +E + + + +A RE L RWQ
Sbjct: 1583 QSKRASFAEKTAQLERS--LQEEHVAVAQLREEAERRAQQQAEAERAREEAERE-LERWQ 1639
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/211 (24%), Positives = 98/211 (46%), Gaps = 21/211 (9%)
Query: 334 KMMKD-LESLQTAEQSLMD---LQERLEKAQEENRNVAVEKQNLERKMMDEINYAKE--E 387
KM+K+ ++++Q A + + LQ++ E AQE+ R + +K+ + +++ +E + E
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2373
Query: 388 ACRLRELREGAECELSRRQYAEQELEQVRMA------LKKAEKEFELRSSWSVPDALQKW 441
A R R+L AE E + + AE Q R K+AE+ E + A Q+
Sbjct: 2374 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEK 2431
Query: 442 LQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKIL 501
+ L +E+Q ++ AIA+ E EK K ++ L ++ + ++L
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLL 2489
Query: 502 EAKKA-----LSELTTCLRERLFRWQQIEKI 527
+ +A LSE + L+ F Q+ K+
Sbjct: 2490 QETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Score = 36.6 bits (83), Expect = 0.099
Identities = 39/148 (26%), Positives = 70/148 (47%), Gaps = 18/148 (12%)
Query: 339 LESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGA 398
L++ + A+Q + Q EK +EE A + E + + + A++E + R+L EG
Sbjct: 1650 LQAEEVAQQKSL-AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 399 ECELSRRQYAEQELEQVRMALKKAEKEFEL------RSSWSVPDALQKWLQLTHEVEVQY 452
+R AEQEL ++R ++ E++ +L R A QK +L E
Sbjct: 1709 ---AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----- 1760
Query: 453 YNIKRQNAEMQLAIAKDEAEKIKKKRST 480
+ + AEM++ +A +A ++ RST
Sbjct: 1761 --LAKVRAEMEVLLA-SKARAEEESRST 1785
Score = 36.2 bits (82), Expect = 0.13
Identities = 35/147 (23%), Positives = 70/147 (47%), Gaps = 21/147 (14%)
Query: 333 AKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAV-EKQNLERKMMDEINYAKEEACRL 391
+++ ++L S++ + L L+ R+E ENR + + +K N +R + +E K+ A
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2284
Query: 392 RELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQ 451
L A+ RQ AE++L Q R +K KE A+Q+ +L E E+
Sbjct: 2285 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE--------KMQAVQEATRLKAEAEL- 2335
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+ Q +A+++A ++++ +
Sbjct: 2336 --------LQQQKELAQEQARRLQEDK 2354
Score = 35.0 bits (79), Expect = 0.29
Identities = 48/198 (24%), Positives = 82/198 (41%), Gaps = 21/198 (10%)
Query: 321 AYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE 380
A + +EHVA E+ + A+Q Q E+A+EE +E+ L+
Sbjct: 1594 AQLERSLQEEHVAVAQLREEAERRAQQ-----QAEAERAREEAER-ELERWQLKANEALR 1647
Query: 381 INYAKEEACRLREL--------REGAECELSRRQYA-EQELEQVRMALKKAEKEFELRSS 431
+ EE + + L +E AE E RR A EQ + Q +A ++ EK+ +L
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1707
Query: 432 WSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSS 491
+ + + E + +RQ E +LA + EA +KR + L +
Sbjct: 1708 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA- 1766
Query: 492 SLDEVDHKILEAKKALSE 509
+ ++L A KA +E
Sbjct: 1767 -----EMEVLLASKARAE 1779
Score = 33.9 bits (76), Expect = 0.64
Identities = 52/233 (22%), Positives = 101/233 (43%), Gaps = 26/233 (11%)
Query: 339 LESLQTAEQS--LMDLQERLEKAQ-------EENRNVAVEKQNLERKMMDEINYAKEEAC 389
L Q AE+ L +++ LEK + + E + L+++M +E+ +E A
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1413
Query: 390 RLRELREGAECELSR-RQYAEQELEQVRMALKKAEK-----EFELRSSWSVPDALQKWLQ 443
++ + + EL + RQ +E E++ + AE+ E E+R +A ++ +
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER-QR 1472
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKI---------KKKRSTVFGTLHVAHSSSLD 494
E E+Q + + AE Q A++EAE++ +K+++ V V +
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1532
Query: 495 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYS 547
+ L+A + L L ER R ++E+ Q+A + S + L S
Sbjct: 1533 REKQRALQALEEL-RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584
Score = 33.9 bits (76), Expect = 0.64
Identities = 43/168 (25%), Positives = 79/168 (47%), Gaps = 26/168 (15%)
Query: 330 EHVAKMMKDLESLQTAEQSLMDLQE----------RLEKAQ-EENRNVAVEKQNLERKMM 378
E +++ + E+ + +++L L+E RL +A+ E R V V + +R
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579
Query: 379 DEI-----NYAKEEACRLRELREGAECELSRRQYAEQELEQ---VRMALKKAEKEFELRS 430
E+ ++A++ A R L+E R+ AE+ +Q A ++AE+E E R
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RW 1638
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+AL+ L+L E Q ++ + AE Q K+EAE+ ++R
Sbjct: 1639 QLKANEALR--LRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR 1680
Score = 33.5 bits (75), Expect = 0.84
Identities = 27/138 (19%), Positives = 61/138 (44%), Gaps = 6/138 (4%)
Query: 338 DLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREG 397
+ E+ + A + + + + E+ ++R E + L++ ++ + +LR+
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145
Query: 398 AECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR 457
AE E +RR AEQ + + A A+ E E ++ QK E E+ ++
Sbjct: 2146 AEQEAARRAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---AQVEQELTTLRLQL 2199
Query: 458 QNAEMQLAIAKDEAEKIK 475
+ + Q + +E +++K
Sbjct: 2200 EETDHQKNLLDEELQRLK 2217
Score = 32.7 bits (73), Expect = 1.4
Identities = 32/141 (22%), Positives = 62/141 (43%), Gaps = 10/141 (7%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AEQ L+ L+ E+ +++ + + E L+R+ +E L ++R E L+
Sbjct: 1715 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1774
Query: 405 RQYAEQELEQVRMALKKAEKEFELRSS--WSVPDALQKWLQLTHEVEVQYYNIKRQNAEM 462
+ AE E+ R +K+++ E + + + + L E + Q RQ AE
Sbjct: 1775 KARAE---EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-----RQLAEE 1826
Query: 463 QLAIAKDEAEKIKKKRSTVFG 483
A + EAE++ ++ G
Sbjct: 1827 DAARQRAEAERVLAEKLAAIG 1847
Score = 30.0 bits (66), Expect = 9.2
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 2/96 (2%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
++ VAK + E Q +Q + ++RL + EE R E + R+ +E+ +++
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2584
Query: 389 CRLRELREGAECELSRRQYAEQELEQVRMALKKAEK 424
+ EL AE R+ + EQ R AL +E+
Sbjct: 2585 RQQEELL--AEENQRLREQLQLLEEQHRAALAHSEE 2618
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 17/180 (9%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AE L L+ R E+A+ + R E + L R++ DE ++ L R AE E +R
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAR 1529
Query: 405 -RQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQ-NAEM 462
+Q A Q LE++R+ ++AE+ Q ++ +V+V +R AE+
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLR-----------QAEVERARQVQVALETAQRSAEAEL 1578
Query: 463 QLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQ 522
Q A + + +RS HVA + +E + + + +A RE L RWQ
Sbjct: 1579 QSKRASFAEKTAQLERS--LQEEHVAVAQLREEAERRAQQQAEAERAREEAERE-LERWQ 1635
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/211 (24%), Positives = 98/211 (46%), Gaps = 21/211 (9%)
Query: 334 KMMKD-LESLQTAEQSLMD---LQERLEKAQEENRNVAVEKQNLERKMMDEINYAKE--E 387
KM+K+ ++++Q A + + LQ++ E AQE+ R + +K+ + +++ +E + E
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 388 ACRLRELREGAECELSRRQYAEQELEQVRMA------LKKAEKEFELRSSWSVPDALQKW 441
A R R+L AE E + + AE Q R K+AE+ E + A Q+
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEK 2427
Query: 442 LQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKIL 501
+ L +E+Q ++ AIA+ E EK K ++ L ++ + ++L
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLL 2485
Query: 502 EAKKA-----LSELTTCLRERLFRWQQIEKI 527
+ +A LSE + L+ F Q+ K+
Sbjct: 2486 QETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Score = 36.6 bits (83), Expect = 0.099
Identities = 39/148 (26%), Positives = 70/148 (47%), Gaps = 18/148 (12%)
Query: 339 LESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGA 398
L++ + A+Q + Q EK +EE A + E + + + A++E + R+L EG
Sbjct: 1646 LQAEEVAQQKSL-AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 399 ECELSRRQYAEQELEQVRMALKKAEKEFEL------RSSWSVPDALQKWLQLTHEVEVQY 452
+R AEQEL ++R ++ E++ +L R A QK +L E
Sbjct: 1705 ---AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----- 1756
Query: 453 YNIKRQNAEMQLAIAKDEAEKIKKKRST 480
+ + AEM++ +A +A ++ RST
Sbjct: 1757 --LAKVRAEMEVLLA-SKARAEEESRST 1781
Score = 36.2 bits (82), Expect = 0.13
Identities = 35/147 (23%), Positives = 70/147 (47%), Gaps = 21/147 (14%)
Query: 333 AKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAV-EKQNLERKMMDEINYAKEEACRL 391
+++ ++L S++ + L L+ R+E ENR + + +K N +R + +E K+ A
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2280
Query: 392 RELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQ 451
L A+ RQ AE++L Q R +K KE A+Q+ +L E E+
Sbjct: 2281 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE--------KMQAVQEATRLKAEAEL- 2331
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+ Q +A+++A ++++ +
Sbjct: 2332 --------LQQQKELAQEQARRLQEDK 2350
Score = 35.0 bits (79), Expect = 0.29
Identities = 48/198 (24%), Positives = 82/198 (41%), Gaps = 21/198 (10%)
Query: 321 AYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE 380
A + +EHVA E+ + A+Q Q E+A+EE +E+ L+
Sbjct: 1590 AQLERSLQEEHVAVAQLREEAERRAQQ-----QAEAERAREEAER-ELERWQLKANEALR 1643
Query: 381 INYAKEEACRLREL--------REGAECELSRRQYA-EQELEQVRMALKKAEKEFELRSS 431
+ EE + + L +E AE E RR A EQ + Q +A ++ EK+ +L
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703
Query: 432 WSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSS 491
+ + + E + +RQ E +LA + EA +KR + L +
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA- 1762
Query: 492 SLDEVDHKILEAKKALSE 509
+ ++L A KA +E
Sbjct: 1763 -----EMEVLLASKARAE 1775
Score = 33.9 bits (76), Expect = 0.64
Identities = 52/233 (22%), Positives = 101/233 (43%), Gaps = 26/233 (11%)
Query: 339 LESLQTAEQS--LMDLQERLEKAQ-------EENRNVAVEKQNLERKMMDEINYAKEEAC 389
L Q AE+ L +++ LEK + + E + L+++M +E+ +E A
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 390 RLRELREGAECELSR-RQYAEQELEQVRMALKKAEK-----EFELRSSWSVPDALQKWLQ 443
++ + + EL + RQ +E E++ + AE+ E E+R +A ++ +
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER-QR 1468
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKI---------KKKRSTVFGTLHVAHSSSLD 494
E E+Q + + AE Q A++EAE++ +K+++ V V +
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1528
Query: 495 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYS 547
+ L+A + L L ER R ++E+ Q+A + S + L S
Sbjct: 1529 REKQRALQALEEL-RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Score = 33.9 bits (76), Expect = 0.64
Identities = 43/168 (25%), Positives = 79/168 (47%), Gaps = 26/168 (15%)
Query: 330 EHVAKMMKDLESLQTAEQSLMDLQE----------RLEKAQ-EENRNVAVEKQNLERKMM 378
E +++ + E+ + +++L L+E RL +A+ E R V V + +R
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575
Query: 379 DEI-----NYAKEEACRLRELREGAECELSRRQYAEQELEQ---VRMALKKAEKEFELRS 430
E+ ++A++ A R L+E R+ AE+ +Q A ++AE+E E R
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RW 1634
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+AL+ L+L E Q ++ + AE Q K+EAE+ ++R
Sbjct: 1635 QLKANEALR--LRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR 1676
Score = 33.5 bits (75), Expect = 0.84
Identities = 27/138 (19%), Positives = 61/138 (44%), Gaps = 6/138 (4%)
Query: 338 DLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREG 397
+ E+ + A + + + + E+ ++R E + L++ ++ + +LR+
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 398 AECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR 457
AE E +RR AEQ + + A A+ E E ++ QK E E+ ++
Sbjct: 2142 AEQEAARRAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---AQVEQELTTLRLQL 2195
Query: 458 QNAEMQLAIAKDEAEKIK 475
+ + Q + +E +++K
Sbjct: 2196 EETDHQKNLLDEELQRLK 2213
Score = 32.7 bits (73), Expect = 1.4
Identities = 32/141 (22%), Positives = 62/141 (43%), Gaps = 10/141 (7%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AEQ L+ L+ E+ +++ + + E L+R+ +E L ++R E L+
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 405 RQYAEQELEQVRMALKKAEKEFELRSS--WSVPDALQKWLQLTHEVEVQYYNIKRQNAEM 462
+ AE E+ R +K+++ E + + + + L E + Q RQ AE
Sbjct: 1771 KARAE---EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-----RQLAEE 1822
Query: 463 QLAIAKDEAEKIKKKRSTVFG 483
A + EAE++ ++ G
Sbjct: 1823 DAARQRAEAERVLAEKLAAIG 1843
Score = 30.0 bits (66), Expect = 9.2
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 2/96 (2%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
++ VAK + E Q +Q + ++RL + EE R E + R+ +E+ +++
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 389 CRLRELREGAECELSRRQYAEQELEQVRMALKKAEK 424
+ EL AE R+ + EQ R AL +E+
Sbjct: 2581 RQQEELL--AEENQRLREQLQLLEEQHRAALAHSEE 2614
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 17/180 (9%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AE L L+ R E+A+ + R E + L R++ DE ++ L R AE E +R
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAR 1497
Query: 405 -RQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQ-NAEM 462
+Q A Q LE++R+ ++AE+ Q ++ +V+V +R AE+
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLR-----------QAEVERARQVQVALETAQRSAEAEL 1546
Query: 463 QLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQ 522
Q A + + +RS HVA + +E + + + +A RE L RWQ
Sbjct: 1547 QSKRASFAEKTAQLERS--LQEEHVAVAQLREEAERRAQQQAEAERAREEAERE-LERWQ 1603
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/211 (24%), Positives = 98/211 (46%), Gaps = 21/211 (9%)
Query: 334 KMMKD-LESLQTAEQSLMD---LQERLEKAQEENRNVAVEKQNLERKMMDEINYAKE--E 387
KM+K+ ++++Q A + + LQ++ E AQE+ R + +K+ + +++ +E + E
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2337
Query: 388 ACRLRELREGAECELSRRQYAEQELEQVRMA------LKKAEKEFELRSSWSVPDALQKW 441
A R R+L AE E + + AE Q R K+AE+ E + A Q+
Sbjct: 2338 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEK 2395
Query: 442 LQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKIL 501
+ L +E+Q ++ AIA+ E EK K ++ L ++ + ++L
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLL 2453
Query: 502 EAKKA-----LSELTTCLRERLFRWQQIEKI 527
+ +A LSE + L+ F Q+ K+
Sbjct: 2454 QETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484
Score = 36.6 bits (83), Expect = 0.099
Identities = 39/148 (26%), Positives = 70/148 (47%), Gaps = 18/148 (12%)
Query: 339 LESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGA 398
L++ + A+Q + Q EK +EE A + E + + + A++E + R+L EG
Sbjct: 1614 LQAEEVAQQKSL-AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672
Query: 399 ECELSRRQYAEQELEQVRMALKKAEKEFEL------RSSWSVPDALQKWLQLTHEVEVQY 452
+R AEQEL ++R ++ E++ +L R A QK +L E
Sbjct: 1673 ---AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----- 1724
Query: 453 YNIKRQNAEMQLAIAKDEAEKIKKKRST 480
+ + AEM++ +A +A ++ RST
Sbjct: 1725 --LAKVRAEMEVLLA-SKARAEEESRST 1749
Score = 36.2 bits (82), Expect = 0.13
Identities = 35/147 (23%), Positives = 70/147 (47%), Gaps = 21/147 (14%)
Query: 333 AKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAV-EKQNLERKMMDEINYAKEEACRL 391
+++ ++L S++ + L L+ R+E ENR + + +K N +R + +E K+ A
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2248
Query: 392 RELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQ 451
L A+ RQ AE++L Q R +K KE A+Q+ +L E E+
Sbjct: 2249 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE--------KMQAVQEATRLKAEAEL- 2299
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+ Q +A+++A ++++ +
Sbjct: 2300 --------LQQQKELAQEQARRLQEDK 2318
Score = 35.0 bits (79), Expect = 0.29
Identities = 48/198 (24%), Positives = 82/198 (41%), Gaps = 21/198 (10%)
Query: 321 AYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE 380
A + +EHVA E+ + A+Q Q E+A+EE +E+ L+
Sbjct: 1558 AQLERSLQEEHVAVAQLREEAERRAQQ-----QAEAERAREEAER-ELERWQLKANEALR 1611
Query: 381 INYAKEEACRLREL--------REGAECELSRRQYA-EQELEQVRMALKKAEKEFELRSS 431
+ EE + + L +E AE E RR A EQ + Q +A ++ EK+ +L
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1671
Query: 432 WSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSS 491
+ + + E + +RQ E +LA + EA +KR + L +
Sbjct: 1672 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA- 1730
Query: 492 SLDEVDHKILEAKKALSE 509
+ ++L A KA +E
Sbjct: 1731 -----EMEVLLASKARAE 1743
Score = 33.9 bits (76), Expect = 0.64
Identities = 52/233 (22%), Positives = 101/233 (43%), Gaps = 26/233 (11%)
Query: 339 LESLQTAEQS--LMDLQERLEKAQ-------EENRNVAVEKQNLERKMMDEINYAKEEAC 389
L Q AE+ L +++ LEK + + E + L+++M +E+ +E A
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1377
Query: 390 RLRELREGAECELSR-RQYAEQELEQVRMALKKAEK-----EFELRSSWSVPDALQKWLQ 443
++ + + EL + RQ +E E++ + AE+ E E+R +A ++ +
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER-QR 1436
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKI---------KKKRSTVFGTLHVAHSSSLD 494
E E+Q + + AE Q A++EAE++ +K+++ V V +
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496
Query: 495 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYS 547
+ L+A + L L ER R ++E+ Q+A + S + L S
Sbjct: 1497 REKQRALQALEEL-RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548
Score = 33.9 bits (76), Expect = 0.64
Identities = 43/168 (25%), Positives = 79/168 (47%), Gaps = 26/168 (15%)
Query: 330 EHVAKMMKDLESLQTAEQSLMDLQE----------RLEKAQ-EENRNVAVEKQNLERKMM 378
E +++ + E+ + +++L L+E RL +A+ E R V V + +R
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543
Query: 379 DEI-----NYAKEEACRLRELREGAECELSRRQYAEQELEQ---VRMALKKAEKEFELRS 430
E+ ++A++ A R L+E R+ AE+ +Q A ++AE+E E R
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RW 1602
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+AL+ L+L E Q ++ + AE Q K+EAE+ ++R
Sbjct: 1603 QLKANEALR--LRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR 1644
Score = 33.5 bits (75), Expect = 0.84
Identities = 27/138 (19%), Positives = 61/138 (44%), Gaps = 6/138 (4%)
Query: 338 DLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREG 397
+ E+ + A + + + + E+ ++R E + L++ ++ + +LR+
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109
Query: 398 AECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR 457
AE E +RR AEQ + + A A+ E E ++ QK E E+ ++
Sbjct: 2110 AEQEAARRAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---AQVEQELTTLRLQL 2163
Query: 458 QNAEMQLAIAKDEAEKIK 475
+ + Q + +E +++K
Sbjct: 2164 EETDHQKNLLDEELQRLK 2181
Score = 32.7 bits (73), Expect = 1.4
Identities = 32/141 (22%), Positives = 62/141 (43%), Gaps = 10/141 (7%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AEQ L+ L+ E+ +++ + + E L+R+ +E L ++R E L+
Sbjct: 1679 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1738
Query: 405 RQYAEQELEQVRMALKKAEKEFELRSS--WSVPDALQKWLQLTHEVEVQYYNIKRQNAEM 462
+ AE E+ R +K+++ E + + + + L E + Q RQ AE
Sbjct: 1739 KARAE---EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-----RQLAEE 1790
Query: 463 QLAIAKDEAEKIKKKRSTVFG 483
A + EAE++ ++ G
Sbjct: 1791 DAARQRAEAERVLAEKLAAIG 1811
Score = 30.0 bits (66), Expect = 9.2
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 2/96 (2%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
++ VAK + E Q +Q + ++RL + EE R E + R+ +E+ +++
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2548
Query: 389 CRLRELREGAECELSRRQYAEQELEQVRMALKKAEK 424
+ EL AE R+ + EQ R AL +E+
Sbjct: 2549 RQQEELL--AEENQRLREQLQLLEEQHRAALAHSEE 2582
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 17/180 (9%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AE L L+ R E+A+ + R E + L R++ DE ++ L R AE E +R
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAR 1666
Query: 405 -RQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQ-NAEM 462
+Q A Q LE++R+ ++AE+ Q ++ +V+V +R AE+
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLR-----------QAEVERARQVQVALETAQRSAEAEL 1715
Query: 463 QLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQ 522
Q A + + +RS HVA + +E + + + +A RE L RWQ
Sbjct: 1716 QSKRASFAEKTAQLERS--LQEEHVAVAQLREEAERRAQQQAEAERAREEAERE-LERWQ 1772
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/211 (24%), Positives = 98/211 (46%), Gaps = 21/211 (9%)
Query: 334 KMMKD-LESLQTAEQSLMD---LQERLEKAQEENRNVAVEKQNLERKMMDEINYAKE--E 387
KM+K+ ++++Q A + + LQ++ E AQE+ R + +K+ + +++ +E + E
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2506
Query: 388 ACRLRELREGAECELSRRQYAEQELEQVRMA------LKKAEKEFELRSSWSVPDALQKW 441
A R R+L AE E + + AE Q R K+AE+ E + A Q+
Sbjct: 2507 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEK 2564
Query: 442 LQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKIL 501
+ L +E+Q ++ AIA+ E EK K ++ L ++ + ++L
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLL 2622
Query: 502 EAKKA-----LSELTTCLRERLFRWQQIEKI 527
+ +A LSE + L+ F Q+ K+
Sbjct: 2623 QETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653
Score = 36.6 bits (83), Expect = 0.099
Identities = 39/148 (26%), Positives = 70/148 (47%), Gaps = 18/148 (12%)
Query: 339 LESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGA 398
L++ + A+Q + Q EK +EE A + E + + + A++E + R+L EG
Sbjct: 1783 LQAEEVAQQKSL-AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841
Query: 399 ECELSRRQYAEQELEQVRMALKKAEKEFEL------RSSWSVPDALQKWLQLTHEVEVQY 452
+R AEQEL ++R ++ E++ +L R A QK +L E
Sbjct: 1842 ---AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----- 1893
Query: 453 YNIKRQNAEMQLAIAKDEAEKIKKKRST 480
+ + AEM++ +A +A ++ RST
Sbjct: 1894 --LAKVRAEMEVLLA-SKARAEEESRST 1918
Score = 36.2 bits (82), Expect = 0.13
Identities = 35/147 (23%), Positives = 70/147 (47%), Gaps = 21/147 (14%)
Query: 333 AKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAV-EKQNLERKMMDEINYAKEEACRL 391
+++ ++L S++ + L L+ R+E ENR + + +K N +R + +E K+ A
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2417
Query: 392 RELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQ 451
L A+ RQ AE++L Q R +K KE A+Q+ +L E E+
Sbjct: 2418 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE--------KMQAVQEATRLKAEAEL- 2468
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+ Q +A+++A ++++ +
Sbjct: 2469 --------LQQQKELAQEQARRLQEDK 2487
Score = 35.0 bits (79), Expect = 0.29
Identities = 48/198 (24%), Positives = 82/198 (41%), Gaps = 21/198 (10%)
Query: 321 AYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE 380
A + +EHVA E+ + A+Q Q E+A+EE +E+ L+
Sbjct: 1727 AQLERSLQEEHVAVAQLREEAERRAQQ-----QAEAERAREEAER-ELERWQLKANEALR 1780
Query: 381 INYAKEEACRLREL--------REGAECELSRRQYA-EQELEQVRMALKKAEKEFELRSS 431
+ EE + + L +E AE E RR A EQ + Q +A ++ EK+ +L
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1840
Query: 432 WSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSS 491
+ + + E + +RQ E +LA + EA +KR + L +
Sbjct: 1841 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA- 1899
Query: 492 SLDEVDHKILEAKKALSE 509
+ ++L A KA +E
Sbjct: 1900 -----EMEVLLASKARAE 1912
Score = 33.9 bits (76), Expect = 0.64
Identities = 52/233 (22%), Positives = 101/233 (43%), Gaps = 26/233 (11%)
Query: 339 LESLQTAEQS--LMDLQERLEKAQ-------EENRNVAVEKQNLERKMMDEINYAKEEAC 389
L Q AE+ L +++ LEK + + E + L+++M +E+ +E A
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1546
Query: 390 RLRELREGAECELSR-RQYAEQELEQVRMALKKAEK-----EFELRSSWSVPDALQKWLQ 443
++ + + EL + RQ +E E++ + AE+ E E+R +A ++ +
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER-QR 1605
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKI---------KKKRSTVFGTLHVAHSSSLD 494
E E+Q + + AE Q A++EAE++ +K+++ V V +
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665
Query: 495 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYS 547
+ L+A + L L ER R ++E+ Q+A + S + L S
Sbjct: 1666 REKQRALQALEEL-RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717
Score = 33.9 bits (76), Expect = 0.64
Identities = 43/168 (25%), Positives = 79/168 (47%), Gaps = 26/168 (15%)
Query: 330 EHVAKMMKDLESLQTAEQSLMDLQE----------RLEKAQ-EENRNVAVEKQNLERKMM 378
E +++ + E+ + +++L L+E RL +A+ E R V V + +R
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712
Query: 379 DEI-----NYAKEEACRLRELREGAECELSRRQYAEQELEQ---VRMALKKAEKEFELRS 430
E+ ++A++ A R L+E R+ AE+ +Q A ++AE+E E R
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RW 1771
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+AL+ L+L E Q ++ + AE Q K+EAE+ ++R
Sbjct: 1772 QLKANEALR--LRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR 1813
Score = 33.5 bits (75), Expect = 0.84
Identities = 27/138 (19%), Positives = 61/138 (44%), Gaps = 6/138 (4%)
Query: 338 DLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREG 397
+ E+ + A + + + + E+ ++R E + L++ ++ + +LR+
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278
Query: 398 AECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR 457
AE E +RR AEQ + + A A+ E E ++ QK E E+ ++
Sbjct: 2279 AEQEAARRAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---AQVEQELTTLRLQL 2332
Query: 458 QNAEMQLAIAKDEAEKIK 475
+ + Q + +E +++K
Sbjct: 2333 EETDHQKNLLDEELQRLK 2350
Score = 32.7 bits (73), Expect = 1.4
Identities = 32/141 (22%), Positives = 62/141 (43%), Gaps = 10/141 (7%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AEQ L+ L+ E+ +++ + + E L+R+ +E L ++R E L+
Sbjct: 1848 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1907
Query: 405 RQYAEQELEQVRMALKKAEKEFELRSS--WSVPDALQKWLQLTHEVEVQYYNIKRQNAEM 462
+ AE E+ R +K+++ E + + + + L E + Q RQ AE
Sbjct: 1908 KARAE---EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-----RQLAEE 1959
Query: 463 QLAIAKDEAEKIKKKRSTVFG 483
A + EAE++ ++ G
Sbjct: 1960 DAARQRAEAERVLAEKLAAIG 1980
Score = 30.0 bits (66), Expect = 9.2
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 2/96 (2%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
++ VAK + E Q +Q + ++RL + EE R E + R+ +E+ +++
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2717
Query: 389 CRLRELREGAECELSRRQYAEQELEQVRMALKKAEK 424
+ EL AE R+ + EQ R AL +E+
Sbjct: 2718 RQQEELL--AEENQRLREQLQLLEEQHRAALAHSEE 2751
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 17/180 (9%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AE L L+ R E+A+ + R E + L R++ DE ++ L R AE E +R
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAR 1507
Query: 405 -RQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQ-NAEM 462
+Q A Q LE++R+ ++AE+ Q ++ +V+V +R AE+
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLR-----------QAEVERARQVQVALETAQRSAEAEL 1556
Query: 463 QLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQ 522
Q A + + +RS HVA + +E + + + +A RE L RWQ
Sbjct: 1557 QSKRASFAEKTAQLERS--LQEEHVAVAQLREEAERRAQQQAEAERAREEAERE-LERWQ 1613
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/211 (24%), Positives = 98/211 (46%), Gaps = 21/211 (9%)
Query: 334 KMMKD-LESLQTAEQSLMD---LQERLEKAQEENRNVAVEKQNLERKMMDEINYAKE--E 387
KM+K+ ++++Q A + + LQ++ E AQE+ R + +K+ + +++ +E + E
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2347
Query: 388 ACRLRELREGAECELSRRQYAEQELEQVRMA------LKKAEKEFELRSSWSVPDALQKW 441
A R R+L AE E + + AE Q R K+AE+ E + A Q+
Sbjct: 2348 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEK 2405
Query: 442 LQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKIL 501
+ L +E+Q ++ AIA+ E EK K ++ L ++ + ++L
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLL 2463
Query: 502 EAKKA-----LSELTTCLRERLFRWQQIEKI 527
+ +A LSE + L+ F Q+ K+
Sbjct: 2464 QETQALQQSFLSEKDSLLQRERFIEQEKAKL 2494
Score = 36.6 bits (83), Expect = 0.099
Identities = 39/148 (26%), Positives = 70/148 (47%), Gaps = 18/148 (12%)
Query: 339 LESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGA 398
L++ + A+Q + Q EK +EE A + E + + + A++E + R+L EG
Sbjct: 1624 LQAEEVAQQKSL-AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682
Query: 399 ECELSRRQYAEQELEQVRMALKKAEKEFEL------RSSWSVPDALQKWLQLTHEVEVQY 452
+R AEQEL ++R ++ E++ +L R A QK +L E
Sbjct: 1683 ---AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----- 1734
Query: 453 YNIKRQNAEMQLAIAKDEAEKIKKKRST 480
+ + AEM++ +A +A ++ RST
Sbjct: 1735 --LAKVRAEMEVLLA-SKARAEEESRST 1759
Score = 36.2 bits (82), Expect = 0.13
Identities = 35/147 (23%), Positives = 70/147 (47%), Gaps = 21/147 (14%)
Query: 333 AKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAV-EKQNLERKMMDEINYAKEEACRL 391
+++ ++L S++ + L L+ R+E ENR + + +K N +R + +E K+ A
Sbjct: 2202 SQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2258
Query: 392 RELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQ 451
L A+ RQ AE++L Q R +K KE A+Q+ +L E E+
Sbjct: 2259 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE--------KMQAVQEATRLKAEAEL- 2309
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+ Q +A+++A ++++ +
Sbjct: 2310 --------LQQQKELAQEQARRLQEDK 2328
Score = 35.0 bits (79), Expect = 0.29
Identities = 48/198 (24%), Positives = 82/198 (41%), Gaps = 21/198 (10%)
Query: 321 AYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE 380
A + +EHVA E+ + A+Q Q E+A+EE +E+ L+
Sbjct: 1568 AQLERSLQEEHVAVAQLREEAERRAQQ-----QAEAERAREEAER-ELERWQLKANEALR 1621
Query: 381 INYAKEEACRLREL--------REGAECELSRRQYA-EQELEQVRMALKKAEKEFELRSS 431
+ EE + + L +E AE E RR A EQ + Q +A ++ EK+ +L
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1681
Query: 432 WSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSS 491
+ + + E + +RQ E +LA + EA +KR + L +
Sbjct: 1682 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA- 1740
Query: 492 SLDEVDHKILEAKKALSE 509
+ ++L A KA +E
Sbjct: 1741 -----EMEVLLASKARAE 1753
Score = 33.9 bits (76), Expect = 0.64
Identities = 52/233 (22%), Positives = 101/233 (43%), Gaps = 26/233 (11%)
Query: 339 LESLQTAEQS--LMDLQERLEKAQ-------EENRNVAVEKQNLERKMMDEINYAKEEAC 389
L Q AE+ L +++ LEK + + E + L+++M +E+ +E A
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1387
Query: 390 RLRELREGAECELSR-RQYAEQELEQVRMALKKAEK-----EFELRSSWSVPDALQKWLQ 443
++ + + EL + RQ +E E++ + AE+ E E+R +A ++ +
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER-QR 1446
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKI---------KKKRSTVFGTLHVAHSSSLD 494
E E+Q + + AE Q A++EAE++ +K+++ V V +
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506
Query: 495 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYS 547
+ L+A + L L ER R ++E+ Q+A + S + L S
Sbjct: 1507 REKQRALQALEEL-RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558
Score = 33.9 bits (76), Expect = 0.64
Identities = 43/168 (25%), Positives = 79/168 (47%), Gaps = 26/168 (15%)
Query: 330 EHVAKMMKDLESLQTAEQSLMDLQE----------RLEKAQ-EENRNVAVEKQNLERKMM 378
E +++ + E+ + +++L L+E RL +A+ E R V V + +R
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
Query: 379 DEI-----NYAKEEACRLRELREGAECELSRRQYAEQELEQ---VRMALKKAEKEFELRS 430
E+ ++A++ A R L+E R+ AE+ +Q A ++AE+E E R
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RW 1612
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+AL+ L+L E Q ++ + AE Q K+EAE+ ++R
Sbjct: 1613 QLKANEALR--LRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR 1654
Score = 33.5 bits (75), Expect = 0.84
Identities = 27/138 (19%), Positives = 61/138 (44%), Gaps = 6/138 (4%)
Query: 338 DLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREG 397
+ E+ + A + + + + E+ ++R E + L++ ++ + +LR+
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119
Query: 398 AECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR 457
AE E +RR AEQ + + A A+ E E ++ QK E E+ ++
Sbjct: 2120 AEQEAARRAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---AQVEQELTTLRLQL 2173
Query: 458 QNAEMQLAIAKDEAEKIK 475
+ + Q + +E +++K
Sbjct: 2174 EETDHQKNLLDEELQRLK 2191
Score = 32.7 bits (73), Expect = 1.4
Identities = 32/141 (22%), Positives = 62/141 (43%), Gaps = 10/141 (7%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AEQ L+ L+ E+ +++ + + E L+R+ +E L ++R E L+
Sbjct: 1689 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1748
Query: 405 RQYAEQELEQVRMALKKAEKEFELRSS--WSVPDALQKWLQLTHEVEVQYYNIKRQNAEM 462
+ AE E+ R +K+++ E + + + + L E + Q RQ AE
Sbjct: 1749 KARAE---EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-----RQLAEE 1800
Query: 463 QLAIAKDEAEKIKKKRSTVFG 483
A + EAE++ ++ G
Sbjct: 1801 DAARQRAEAERVLAEKLAAIG 1821
Score = 30.0 bits (66), Expect = 9.2
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 2/96 (2%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
++ VAK + E Q +Q + ++RL + EE R E + R+ +E+ +++
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2558
Query: 389 CRLRELREGAECELSRRQYAEQELEQVRMALKKAEK 424
+ EL AE R+ + EQ R AL +E+
Sbjct: 2559 RQQEELL--AEENQRLREQLQLLEEQHRAALAHSEE 2592
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 17/180 (9%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AE L L+ R E+A+ + R E + L R++ DE ++ L R AE E +R
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAR 1515
Query: 405 -RQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQ-NAEM 462
+Q A Q LE++R+ ++AE+ Q ++ +V+V +R AE+
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLR-----------QAEVERARQVQVALETAQRSAEAEL 1564
Query: 463 QLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQ 522
Q A + + +RS HVA + +E + + + +A RE L RWQ
Sbjct: 1565 QSKRASFAEKTAQLERS--LQEEHVAVAQLREEAERRAQQQAEAERAREEAERE-LERWQ 1621
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/211 (24%), Positives = 98/211 (46%), Gaps = 21/211 (9%)
Query: 334 KMMKD-LESLQTAEQSLMD---LQERLEKAQEENRNVAVEKQNLERKMMDEINYAKE--E 387
KM+K+ ++++Q A + + LQ++ E AQE+ R + +K+ + +++ +E + E
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2355
Query: 388 ACRLRELREGAECELSRRQYAEQELEQVRMA------LKKAEKEFELRSSWSVPDALQKW 441
A R R+L AE E + + AE Q R K+AE+ E + A Q+
Sbjct: 2356 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEK 2413
Query: 442 LQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKIL 501
+ L +E+Q ++ AIA+ E EK K ++ L ++ + ++L
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLL 2471
Query: 502 EAKKA-----LSELTTCLRERLFRWQQIEKI 527
+ +A LSE + L+ F Q+ K+
Sbjct: 2472 QETQALQQSFLSEKDSLLQRERFIEQEKAKL 2502
Score = 36.6 bits (83), Expect = 0.099
Identities = 39/148 (26%), Positives = 70/148 (47%), Gaps = 18/148 (12%)
Query: 339 LESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGA 398
L++ + A+Q + Q EK +EE A + E + + + A++E + R+L EG
Sbjct: 1632 LQAEEVAQQKSL-AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690
Query: 399 ECELSRRQYAEQELEQVRMALKKAEKEFEL------RSSWSVPDALQKWLQLTHEVEVQY 452
+R AEQEL ++R ++ E++ +L R A QK +L E
Sbjct: 1691 ---AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----- 1742
Query: 453 YNIKRQNAEMQLAIAKDEAEKIKKKRST 480
+ + AEM++ +A +A ++ RST
Sbjct: 1743 --LAKVRAEMEVLLA-SKARAEEESRST 1767
Score = 36.2 bits (82), Expect = 0.13
Identities = 35/147 (23%), Positives = 70/147 (47%), Gaps = 21/147 (14%)
Query: 333 AKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAV-EKQNLERKMMDEINYAKEEACRL 391
+++ ++L S++ + L L+ R+E ENR + + +K N +R + +E K+ A
Sbjct: 2210 SQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2266
Query: 392 RELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQ 451
L A+ RQ AE++L Q R +K KE A+Q+ +L E E+
Sbjct: 2267 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE--------KMQAVQEATRLKAEAEL- 2317
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+ Q +A+++A ++++ +
Sbjct: 2318 --------LQQQKELAQEQARRLQEDK 2336
Score = 35.0 bits (79), Expect = 0.29
Identities = 48/198 (24%), Positives = 82/198 (41%), Gaps = 21/198 (10%)
Query: 321 AYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE 380
A + +EHVA E+ + A+Q Q E+A+EE +E+ L+
Sbjct: 1576 AQLERSLQEEHVAVAQLREEAERRAQQ-----QAEAERAREEAER-ELERWQLKANEALR 1629
Query: 381 INYAKEEACRLREL--------REGAECELSRRQYA-EQELEQVRMALKKAEKEFELRSS 431
+ EE + + L +E AE E RR A EQ + Q +A ++ EK+ +L
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1689
Query: 432 WSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSS 491
+ + + E + +RQ E +LA + EA +KR + L +
Sbjct: 1690 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA- 1748
Query: 492 SLDEVDHKILEAKKALSE 509
+ ++L A KA +E
Sbjct: 1749 -----EMEVLLASKARAE 1761
Score = 33.9 bits (76), Expect = 0.64
Identities = 52/233 (22%), Positives = 101/233 (43%), Gaps = 26/233 (11%)
Query: 339 LESLQTAEQS--LMDLQERLEKAQ-------EENRNVAVEKQNLERKMMDEINYAKEEAC 389
L Q AE+ L +++ LEK + + E + L+++M +E+ +E A
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1395
Query: 390 RLRELREGAECELSR-RQYAEQELEQVRMALKKAEK-----EFELRSSWSVPDALQKWLQ 443
++ + + EL + RQ +E E++ + AE+ E E+R +A ++ +
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER-QR 1454
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKI---------KKKRSTVFGTLHVAHSSSLD 494
E E+Q + + AE Q A++EAE++ +K+++ V V +
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1514
Query: 495 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYS 547
+ L+A + L L ER R ++E+ Q+A + S + L S
Sbjct: 1515 REKQRALQALEEL-RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566
Score = 33.9 bits (76), Expect = 0.64
Identities = 43/168 (25%), Positives = 79/168 (47%), Gaps = 26/168 (15%)
Query: 330 EHVAKMMKDLESLQTAEQSLMDLQE----------RLEKAQ-EENRNVAVEKQNLERKMM 378
E +++ + E+ + +++L L+E RL +A+ E R V V + +R
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561
Query: 379 DEI-----NYAKEEACRLRELREGAECELSRRQYAEQELEQ---VRMALKKAEKEFELRS 430
E+ ++A++ A R L+E R+ AE+ +Q A ++AE+E E R
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RW 1620
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+AL+ L+L E Q ++ + AE Q K+EAE+ ++R
Sbjct: 1621 QLKANEALR--LRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR 1662
Score = 33.5 bits (75), Expect = 0.84
Identities = 27/138 (19%), Positives = 61/138 (44%), Gaps = 6/138 (4%)
Query: 338 DLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREG 397
+ E+ + A + + + + E+ ++R E + L++ ++ + +LR+
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127
Query: 398 AECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR 457
AE E +RR AEQ + + A A+ E E ++ QK E E+ ++
Sbjct: 2128 AEQEAARRAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---AQVEQELTTLRLQL 2181
Query: 458 QNAEMQLAIAKDEAEKIK 475
+ + Q + +E +++K
Sbjct: 2182 EETDHQKNLLDEELQRLK 2199
Score = 32.7 bits (73), Expect = 1.4
Identities = 32/141 (22%), Positives = 62/141 (43%), Gaps = 10/141 (7%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AEQ L+ L+ E+ +++ + + E L+R+ +E L ++R E L+
Sbjct: 1697 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1756
Query: 405 RQYAEQELEQVRMALKKAEKEFELRSS--WSVPDALQKWLQLTHEVEVQYYNIKRQNAEM 462
+ AE E+ R +K+++ E + + + + L E + Q RQ AE
Sbjct: 1757 KARAE---EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-----RQLAEE 1808
Query: 463 QLAIAKDEAEKIKKKRSTVFG 483
A + EAE++ ++ G
Sbjct: 1809 DAARQRAEAERVLAEKLAAIG 1829
Score = 30.0 bits (66), Expect = 9.2
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 2/96 (2%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
++ VAK + E Q +Q + ++RL + EE R E + R+ +E+ +++
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2566
Query: 389 CRLRELREGAECELSRRQYAEQELEQVRMALKKAEK 424
+ EL AE R+ + EQ R AL +E+
Sbjct: 2567 RQQEELL--AEENQRLREQLQLLEEQHRAALAHSEE 2600
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 45.1 bits (105), Expect = 3e-04
Identities = 48/180 (26%), Positives = 80/180 (44%), Gaps = 17/180 (9%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AE L L+ R E+A+ + R E + L R++ DE ++ L R AE E +R
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS-RVKAEAEAAR 1556
Query: 405 -RQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQ-NAEM 462
+Q A Q LE++R+ ++AE+ Q ++ +V+V +R AE+
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLR-----------QAEVERARQVQVALETAQRSAEAEL 1605
Query: 463 QLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQ 522
Q A + + +RS HVA + +E + + + +A RE L RWQ
Sbjct: 1606 QSKRASFAEKTAQLERS--LQEEHVAVAQLREEAERRAQQQAEAERAREEAERE-LERWQ 1662
Score = 40.8 bits (94), Expect = 0.005
Identities = 52/211 (24%), Positives = 98/211 (46%), Gaps = 21/211 (9%)
Query: 334 KMMKD-LESLQTAEQSLMD---LQERLEKAQEENRNVAVEKQNLERKMMDEINYAKE--E 387
KM+K+ ++++Q A + + LQ++ E AQE+ R + +K+ + +++ +E + E
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2396
Query: 388 ACRLRELREGAECELSRRQYAEQELEQVRMA------LKKAEKEFELRSSWSVPDALQKW 441
A R R+L AE E + + AE Q R K+AE+ E + A Q+
Sbjct: 2397 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL--ATQEK 2454
Query: 442 LQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKIL 501
+ L +E+Q ++ AIA+ E EK K ++ L ++ + ++L
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLL 2512
Query: 502 EAKKA-----LSELTTCLRERLFRWQQIEKI 527
+ +A LSE + L+ F Q+ K+
Sbjct: 2513 QETQALQQSFLSEKDSLLQRERFIEQEKAKL 2543
Score = 36.6 bits (83), Expect = 0.099
Identities = 39/148 (26%), Positives = 70/148 (47%), Gaps = 18/148 (12%)
Query: 339 LESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGA 398
L++ + A+Q + Q EK +EE A + E + + + A++E + R+L EG
Sbjct: 1673 LQAEEVAQQKSL-AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731
Query: 399 ECELSRRQYAEQELEQVRMALKKAEKEFEL------RSSWSVPDALQKWLQLTHEVEVQY 452
+R AEQEL ++R ++ E++ +L R A QK +L E
Sbjct: 1732 ---AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE----- 1783
Query: 453 YNIKRQNAEMQLAIAKDEAEKIKKKRST 480
+ + AEM++ +A +A ++ RST
Sbjct: 1784 --LAKVRAEMEVLLA-SKARAEEESRST 1808
Score = 36.2 bits (82), Expect = 0.13
Identities = 35/147 (23%), Positives = 70/147 (47%), Gaps = 21/147 (14%)
Query: 333 AKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAV-EKQNLERKMMDEINYAKEEACRL 391
+++ ++L S++ + L L+ R+E ENR + + +K N +R + +E K+ A
Sbjct: 2251 SQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNTQRFLQEEAEKMKQVAEEA 2307
Query: 392 RELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQ 451
L A+ RQ AE++L Q R +K KE A+Q+ +L E E+
Sbjct: 2308 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE--------KMQAVQEATRLKAEAEL- 2358
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+ Q +A+++A ++++ +
Sbjct: 2359 --------LQQQKELAQEQARRLQEDK 2377
Score = 35.0 bits (79), Expect = 0.29
Identities = 48/198 (24%), Positives = 82/198 (41%), Gaps = 21/198 (10%)
Query: 321 AYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE 380
A + +EHVA E+ + A+Q Q E+A+EE +E+ L+
Sbjct: 1617 AQLERSLQEEHVAVAQLREEAERRAQQ-----QAEAERAREEAER-ELERWQLKANEALR 1670
Query: 381 INYAKEEACRLREL--------REGAECELSRRQYA-EQELEQVRMALKKAEKEFELRSS 431
+ EE + + L +E AE E RR A EQ + Q +A ++ EK+ +L
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1730
Query: 432 WSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSS 491
+ + + E + +RQ E +LA + EA +KR + L +
Sbjct: 1731 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA- 1789
Query: 492 SLDEVDHKILEAKKALSE 509
+ ++L A KA +E
Sbjct: 1790 -----EMEVLLASKARAE 1802
Score = 33.9 bits (76), Expect = 0.64
Identities = 52/233 (22%), Positives = 101/233 (43%), Gaps = 26/233 (11%)
Query: 339 LESLQTAEQS--LMDLQERLEKAQ-------EENRNVAVEKQNLERKMMDEINYAKEEAC 389
L Q AE+ L +++ LEK + + E + L+++M +E+ +E A
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1436
Query: 390 RLRELREGAECELSR-RQYAEQELEQVRMALKKAEK-----EFELRSSWSVPDALQKWLQ 443
++ + + EL + RQ +E E++ + AE+ E E+R +A ++ +
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER-QR 1495
Query: 444 LTHEVEVQYYNIKRQNAEMQLAIAKDEAEKI---------KKKRSTVFGTLHVAHSSSLD 494
E E+Q + + AE Q A++EAE++ +K+++ V V +
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1555
Query: 495 EVDHKILEAKKALSELTTCLRERLFRWQQIEKICGFQIAHNSGLPSLTSSLYS 547
+ L+A + L L ER R ++E+ Q+A + S + L S
Sbjct: 1556 REKQRALQALEEL-RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607
Score = 33.9 bits (76), Expect = 0.64
Identities = 43/168 (25%), Positives = 79/168 (47%), Gaps = 26/168 (15%)
Query: 330 EHVAKMMKDLESLQTAEQSLMDLQE----------RLEKAQ-EENRNVAVEKQNLERKMM 378
E +++ + E+ + +++L L+E RL +A+ E R V V + +R
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602
Query: 379 DEI-----NYAKEEACRLRELREGAECELSRRQYAEQELEQ---VRMALKKAEKEFELRS 430
E+ ++A++ A R L+E R+ AE+ +Q A ++AE+E E R
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-RW 1661
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKR 478
+AL+ L+L E Q ++ + AE Q K+EAE+ ++R
Sbjct: 1662 QLKANEALR--LRLQAEEVAQQKSLAQAEAEKQ----KEEAEREARRR 1703
Score = 33.5 bits (75), Expect = 0.84
Identities = 27/138 (19%), Positives = 61/138 (44%), Gaps = 6/138 (4%)
Query: 338 DLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREG 397
+ E+ + A + + + + E+ ++R E + L++ ++ + +LR+
Sbjct: 2109 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2168
Query: 398 AECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR 457
AE E +RR AEQ + + A A+ E E ++ QK E E+ ++
Sbjct: 2169 AEQEAARRAQAEQAALRQKQA---ADAEMEKHKKFAEQTLRQK---AQVEQELTTLRLQL 2222
Query: 458 QNAEMQLAIAKDEAEKIK 475
+ + Q + +E +++K
Sbjct: 2223 EETDHQKNLLDEELQRLK 2240
Score = 32.7 bits (73), Expect = 1.4
Identities = 32/141 (22%), Positives = 62/141 (43%), Gaps = 10/141 (7%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSR 404
AEQ L+ L+ E+ +++ + + E L+R+ +E L ++R E L+
Sbjct: 1738 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1797
Query: 405 RQYAEQELEQVRMALKKAEKEFELRSS--WSVPDALQKWLQLTHEVEVQYYNIKRQNAEM 462
+ AE E+ R +K+++ E + + + + L E + Q RQ AE
Sbjct: 1798 KARAE---EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-----RQLAEE 1849
Query: 463 QLAIAKDEAEKIKKKRSTVFG 483
A + EAE++ ++ G
Sbjct: 1850 DAARQRAEAERVLAEKLAAIG 1870
Score = 30.0 bits (66), Expect = 9.2
Identities = 25/96 (26%), Positives = 45/96 (46%), Gaps = 2/96 (2%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEA 388
++ VAK + E Q +Q + ++RL + EE R E + R+ +E+ +++
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2607
Query: 389 CRLRELREGAECELSRRQYAEQELEQVRMALKKAEK 424
+ EL AE R+ + EQ R AL +E+
Sbjct: 2608 RQQEELL--AEENQRLREQLQLLEEQHRAALAHSEE 2641
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 43.9 bits (102), Expect = 6e-04
Identities = 38/193 (19%), Positives = 85/193 (44%), Gaps = 13/193 (6%)
Query: 324 QNKTSKEHVAKMMKDLESLQTAEQSLM-----DLQERLEKAQEENR-----NVAVEKQNL 373
Q T K+H +++ S+ T + ++ +L E+++KA+EE + ++ K
Sbjct: 929 QEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAF 988
Query: 374 ERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWS 433
E+ + E + +L E+ + ++ R++ Q+L + +K + E
Sbjct: 989 EKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQERE-K 1047
Query: 434 VPDALQKWLQLTHEVEVQYYN--IKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSS 491
+ K + ++++ Q R +MQLA + + E+++ K + + VA
Sbjct: 1048 FNQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFP 1107
Query: 492 SLDEVDHKILEAK 504
S DE D + E++
Sbjct: 1108 SADETDGNLPESR 1120
Score = 32.3 bits (72), Expect = 1.9
Identities = 36/190 (18%), Positives = 82/190 (43%), Gaps = 20/190 (10%)
Query: 326 KTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQ-------EENRNVAVEKQNLERKMM 378
+TS + K+MK+L+ ++L ++EK + E + A ++ R +
Sbjct: 454 RTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVE 513
Query: 379 DEINYAKEEACRLRELREGAECELSRRQYAEQELEQVR--------MALKKAEKEFELRS 430
+E++ K++ L+++ + ++ + +++LE+ A++ + E+
Sbjct: 514 NEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSK 573
Query: 431 SWSVPDALQKWLQLTHEVEVQYYNIKRQNAE--MQLAIAKDEAEKIKKKRSTVFGTLHVA 488
S S ++L + LQ + + N K Q + QL + + + S + G L
Sbjct: 574 SISQLESLNRELQERNRI---LENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQAR 630
Query: 489 HSSSLDEVDH 498
+S +EV H
Sbjct: 631 ITSLQEEVKH 640
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 43.9 bits (102), Expect = 6e-04
Identities = 46/188 (24%), Positives = 80/188 (42%), Gaps = 29/188 (15%)
Query: 325 NKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMD---EI 381
N T E K+M ++ L D + EK +EE + EK L+R++ D E+
Sbjct: 480 NITVNEDQIKLMN--VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL 537
Query: 382 NYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKW 441
++++E+ R R+ E +L+ + +E ++ + A + +K
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASES-------------RKE 584
Query: 442 LQLTHEVEVQYYNI------KRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLD- 494
L+L HE EV Y I K +NA + EAE + + +F H S L
Sbjct: 585 LELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS--HEEELSKLKE 642
Query: 495 --EVDHKI 500
E++H+I
Sbjct: 643 DLEIEHRI 650
Score = 38.5 bits (88), Expect = 0.026
Identities = 35/166 (21%), Positives = 76/166 (45%), Gaps = 14/166 (8%)
Query: 320 FAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMD 379
F + K ++ + +++ E+ + +L+E+LE+ +EE N E Q L ++
Sbjct: 2176 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL-- 2233
Query: 380 EINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQ 439
EI KE RL+EL + + + ++E++ +A+ KE + S+
Sbjct: 2234 EIQ-KKESTTRLQELEQ-------ENKLFKDDMEKLGLAI----KESDAMSTQDQHVLFG 2281
Query: 440 KWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTL 485
K+ Q+ E EV+ + Q ++Q + K+ ++++ + L
Sbjct: 2282 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL 2327
Score = 37.4 bits (85), Expect = 0.058
Identities = 36/176 (20%), Positives = 81/176 (46%), Gaps = 28/176 (15%)
Query: 330 EHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEAC 389
E K ++ + L TA++ L +LQE++ + +E +N+ +E N ++K K+
Sbjct: 340 EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMG 399
Query: 390 RLRELRE------GAECELSRR--QYAEQELEQVRMALKK-------------------A 422
+ EL++ E ++ +R Q +++LEQ+R L +
Sbjct: 400 TVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQ 459
Query: 423 EKEFELRSSWSVPDALQKWLQLT-HEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKK 477
+E + R + +AL+ + +T +E +++ N+ ++L + EK+K++
Sbjct: 460 MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEE 515
Score = 33.9 bits (76), Expect = 0.64
Identities = 33/192 (17%), Positives = 82/192 (42%), Gaps = 14/192 (7%)
Query: 335 MMKDLESLQ-TAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEE----AC 389
+M D E ++ E+ + L E +EK Q+E N+ + + +E + K +
Sbjct: 2334 LMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIA 2393
Query: 390 RLRELREGAECELSRRQYAEQELEQVRMALKKAEKE-FELRSSWSVPDALQKWLQLTHEV 448
L + E + + L++ + + +E F L+ + +Q + + V
Sbjct: 2394 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPE--NSV 2451
Query: 449 EVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALS 508
V ++ + E+++ + +D + ++ + T F + S+ ++ ++L+ + +S
Sbjct: 2452 NVAIDHLSKDKPELEVVLTEDALKSLENQ--TYFKSFEENGKGSIINLETRLLQLESTVS 2509
Query: 509 ----ELTTCLRE 516
ELT C ++
Sbjct: 2510 AKDLELTQCYKQ 2521
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 43.9 bits (102), Expect = 6e-04
Identities = 46/188 (24%), Positives = 80/188 (42%), Gaps = 29/188 (15%)
Query: 325 NKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMD---EI 381
N T E K+M ++ L D + EK +EE + EK L+R++ D E+
Sbjct: 480 NITVNEDQIKLMN--VAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL 537
Query: 382 NYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKW 441
++++E+ R R+ E +L+ + +E ++ + A + +K
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASES-------------RKE 584
Query: 442 LQLTHEVEVQYYNI------KRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLD- 494
L+L HE EV Y I K +NA + EAE + + +F H S L
Sbjct: 585 LELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS--HEEELSKLKE 642
Query: 495 --EVDHKI 500
E++H+I
Sbjct: 643 DLEIEHRI 650
Score = 38.5 bits (88), Expect = 0.026
Identities = 35/166 (21%), Positives = 76/166 (45%), Gaps = 14/166 (8%)
Query: 320 FAYTQNKTSKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMD 379
F + K ++ + +++ E+ + +L+E+LE+ +EE N E Q L ++
Sbjct: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQL-- 2225
Query: 380 EINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQ 439
EI KE RL+EL + + + ++E++ +A+ KE + S+
Sbjct: 2226 EIQ-KKESTTRLQELEQ-------ENKLFKDDMEKLGLAI----KESDAMSTQDQHVLFG 2273
Query: 440 KWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTL 485
K+ Q+ E EV+ + Q ++Q + K+ ++++ + L
Sbjct: 2274 KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDL 2319
Score = 37.4 bits (85), Expect = 0.058
Identities = 36/176 (20%), Positives = 81/176 (46%), Gaps = 28/176 (15%)
Query: 330 EHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEAC 389
E K ++ + L TA++ L +LQE++ + +E +N+ +E N ++K K+
Sbjct: 340 EEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMG 399
Query: 390 RLRELRE------GAECELSRR--QYAEQELEQVRMALKK-------------------A 422
+ EL++ E ++ +R Q +++LEQ+R L +
Sbjct: 400 TVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQ 459
Query: 423 EKEFELRSSWSVPDALQKWLQLT-HEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKK 477
+E + R + +AL+ + +T +E +++ N+ ++L + EK+K++
Sbjct: 460 MEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEE 515
Score = 33.9 bits (76), Expect = 0.64
Identities = 33/192 (17%), Positives = 82/192 (42%), Gaps = 14/192 (7%)
Query: 335 MMKDLESLQ-TAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEE----AC 389
+M D E ++ E+ + L E +EK Q+E N+ + + +E + K +
Sbjct: 2326 LMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIA 2385
Query: 390 RLRELREGAECELSRRQYAEQELEQVRMALKKAEKE-FELRSSWSVPDALQKWLQLTHEV 448
L + E + + L++ + + +E F L+ + +Q + + V
Sbjct: 2386 EKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPE--NSV 2443
Query: 449 EVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALS 508
V ++ + E+++ + +D + ++ + T F + S+ ++ ++L+ + +S
Sbjct: 2444 NVAIDHLSKDKPELEVVLTEDALKSLENQ--TYFKSFEENGKGSIINLETRLLQLESTVS 2501
Query: 509 ----ELTTCLRE 516
ELT C ++
Sbjct: 2502 AKDLELTQCYKQ 2513
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 43.9 bits (102), Expect = 6e-04
Identities = 58/241 (24%), Positives = 109/241 (45%), Gaps = 18/241 (7%)
Query: 324 QNKTSKEHVAKMMKDL-----ESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMM 378
Q++ KE K +DL ES++ + L+ LEK Q E + K N K
Sbjct: 467 QSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEK-QSETVDELTGKNNQILKEK 525
Query: 379 DEINYAKEEACR-LRELREGAECELSRRQYAEQELEQVRMALK-----KAEKEFELRSSW 432
DE+ A + + LR+ L++R E+EL L+ +A+ E E+++S
Sbjct: 526 DELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSL 585
Query: 433 S----VPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTV-FGTLHV 487
+ L+K ++ +++V+ +++ + AE++ + A+D+A+ ++ + S +
Sbjct: 586 DTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRA 645
Query: 488 AHSSSLDEVDHKILEAKKALSELTTCLRERLFRWQQ-IEKICGFQIAHNSGLPSLTSSLY 546
++ L E + K LS+LT + R I ++ + H L LTSSL
Sbjct: 646 DLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQ 705
Query: 547 S 547
S
Sbjct: 706 S 706
Score = 39.3 bits (90), Expect = 0.015
Identities = 39/193 (20%), Positives = 85/193 (44%), Gaps = 10/193 (5%)
Query: 329 KEHVAKMMKDLE---SLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAK 385
K+ + K M DL + L +++ +E+ +E ++A + +NL R++ +
Sbjct: 358 KQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQL 417
Query: 386 EEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLT 445
+ RL+E++ + + R++A+ ++ ++ + A K+ E S LQ+ L
Sbjct: 418 QMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLS-----ELQQSEALK 472
Query: 446 HEVEV--QYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEA 503
E E + +K Q + Q + + E+ +K+S L ++ L E D +
Sbjct: 473 EEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQL 532
Query: 504 KKALSELTTCLRE 516
AL ++ +E
Sbjct: 533 YAALQQIENLRKE 545
Score = 38.1 bits (87), Expect = 0.034
Identities = 57/234 (24%), Positives = 99/234 (42%), Gaps = 39/234 (16%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEEN----RNVAVEKQNLERKMMD---EI 381
+ + K D + LQ + Q + Q E+ R V EKQ+LE++M D ++
Sbjct: 313 RTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQL 372
Query: 382 NYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKE--------FELRSSWS 433
N++ A L E++ E + + + ++E + L+ EK+ E+++ +
Sbjct: 373 NFS-AMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFD 431
Query: 434 VPDALQKWL-----QLTHEVEVQYYNIKRQNAEMQLAIA-KDEAEK----IKKKRSTVFG 483
+A +K +LT E +R +E+Q + A K+EAEK +K K
Sbjct: 432 TCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIR 491
Query: 484 TLHVAH----------SSSLDEVDHKILEAKKALSELTTCLRERLFRWQQIEKI 527
+ H S ++DE+ K + K EL T L L QQIE +
Sbjct: 492 QWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAAL---QQIENL 542
Score = 32.7 bits (73), Expect = 1.4
Identities = 27/105 (25%), Positives = 53/105 (50%), Gaps = 14/105 (13%)
Query: 323 TQNKTSKEHVAKMMKDL-ESLQTA----EQSLMDLQERL--EKAQEENRNVAVEKQNLER 375
TQ K ++ + +KDL SLQ+ EQ++ +L + EK++ EN ++ ++LE
Sbjct: 684 TQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEE 743
Query: 376 KMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALK 420
K M +I+ + E + ++C+ + + E E ++ LK
Sbjct: 744 KNMAKIHRGQLEKLK-------SQCDRLTEELTQNENENKKLKLK 781
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 43.9 bits (102), Expect = 6e-04
Identities = 47/195 (24%), Positives = 80/195 (41%), Gaps = 22/195 (11%)
Query: 328 SKEHVAKMMKDLE--------SLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMD 379
S E K+ DLE L+ A++S MD + ++ E+ + E NL+ K+ D
Sbjct: 1041 SLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIED 1100
Query: 380 EINYA-------KEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSW 432
E A KE R+ EL E E E + R AE++ + L++ + E
Sbjct: 1101 EQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLE----- 1155
Query: 433 SVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSS 492
A +++ + E ++ ++R E L + A ++KK + L S
Sbjct: 1156 EAGGATSAQIEMNKKREAEFQKMRRDLEESTLQ-HEATAAALRKKHADSVAELG-EQIDS 1213
Query: 493 LDEVDHKILEAKKAL 507
L V K+ + K L
Sbjct: 1214 LQRVKQKLEKEKSEL 1228
Score = 43.5 bits (101), Expect = 8e-04
Identities = 45/178 (25%), Positives = 83/178 (46%), Gaps = 23/178 (12%)
Query: 339 LESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKM---MDEIN----YAKEEACRL 391
L+S +T E+ + +++E EK +EE +++ LE KM M E N + EA L
Sbjct: 844 LKSAET-EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADAL 902
Query: 392 RELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQ 451
+ E + + + E ++++V ++AE E E+ + + ++E +
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIKEV---TERAEDEEEINAELTAK---------KRKLEDE 950
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSE 509
+K+ +++L +AK E EK + T +A LDE K+ + KKAL E
Sbjct: 951 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA---GLDETIAKLTKEKKALQE 1005
Score = 34.7 bits (78), Expect = 0.38
Identities = 35/144 (24%), Positives = 65/144 (45%), Gaps = 19/144 (13%)
Query: 345 AEQSLMDLQERLEKAQEENRNVAVEKQNLE----------RKMMDEINYAKEEACR-LRE 393
AEQ L+D ER++ +N ++ K+ LE ++ E A+E+A + + +
Sbjct: 1706 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITD 1765
Query: 394 LREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDAL-------QKWLQLTH 446
AE EL + Q LE+++ +++ K+ +LR + AL QK
Sbjct: 1766 AAMMAE-ELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1824
Query: 447 EVEVQYYNIKRQNAEMQLAIAKDE 470
E+E + + ++ N E + K E
Sbjct: 1825 ELESEVESEQKHNVEAVKGLRKHE 1848
Score = 32.7 bits (73), Expect = 1.4
Identities = 29/171 (16%), Positives = 72/171 (42%), Gaps = 6/171 (3%)
Query: 346 EQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRR 405
++ + +LQ R+E+ +EE + E++ D +E + RL E ++
Sbjct: 1109 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1168
Query: 406 QYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVE-----VQYYNIKRQNA 460
+ E E +++R L+++ + E ++ +L +++ Q ++
Sbjct: 1169 KKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSEL 1228
Query: 461 EMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSELT 511
+M++ E + K ++ F + L E+ K E ++ ++EL+
Sbjct: 1229 KMEINDLASNMETVSKAKAN-FEKMCRTLEDQLSEIKTKEEEQQRLINELS 1278
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 43.5 bits (101), Expect = 8e-04
Identities = 52/215 (24%), Positives = 92/215 (42%), Gaps = 40/215 (18%)
Query: 324 QNKTSKEHVAKMMKDLESLQTAEQSLMDLQERL----------EKAQEENRNVAVEK-QN 372
Q + E KM + E + E+ + +L+E++ EK QEE + EK Q
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 427
Query: 373 LERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSW 432
E KM + +E+ ++RE E ++ R++ E E++R K+ E+E R
Sbjct: 428 QEAKMWRQEEKIREQEEKIRE----QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 483
Query: 433 SVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSS 492
+ HE E I RQ +M ++ EKI+K+ V+
Sbjct: 484 KI-----------HEQE----EIWRQKEKMH-----EQEEKIRKQEEKVW-----RQEEK 518
Query: 493 LDEVDHKILEAKKALSELTTCLRERLFRWQQIEKI 527
+ E + KI E ++ + +RE+ W++ EK+
Sbjct: 519 IREQEEKIREQEEKMWRQEEKIREQEEMWREEEKM 553
Score = 32.3 bits (72), Expect = 1.9
Identities = 35/166 (21%), Positives = 76/166 (45%), Gaps = 29/166 (17%)
Query: 323 TQNKTSKEHVAKMMKDLE--SLQTAEQSLMD---------LQERLEKAQEENRNVAVEKQ 371
TQ K + ++ ++ K+ + SL+ ++ D LQE+L+ + E + + +
Sbjct: 186 TQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVK 245
Query: 372 NLERKMMDEINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSS 431
L+RK+ E +L ++ + E + +EL+ V L+ +E EL +
Sbjct: 246 ELKRKL---------ERAKLLLPQQQLQAE---ADHLGKELQSVSAKLQAQVEENELWNR 293
Query: 432 WSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKK 477
+ + W Q E ++Q + K Q E ++ +++ EKI+++
Sbjct: 294 LNQQQEEKMWRQ---EEKIQEWEEKIQEQEEKI---REQEEKIREQ 333
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 43.5 bits (101), Expect = 8e-04
Identities = 45/178 (25%), Positives = 83/178 (46%), Gaps = 23/178 (12%)
Query: 339 LESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKM---MDEIN----YAKEEACRL 391
L+S +T E+ + +++E EK +EE +++ LE KM M E N + EA L
Sbjct: 844 LKSAET-EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902
Query: 392 RELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQ 451
+ E + + + E ++++V ++AE E E+ + + ++E +
Sbjct: 903 ADAEERCDQLIKTKIQLEAKIKEV---TERAEDEEEINAELTAK---------KRKLEDE 950
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILEAKKALSE 509
+K+ +++L +AK E EK + T +A LDE K+ + KKAL E
Sbjct: 951 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMA---GLDETIAKLTKEKKALQE 1005
Score = 37.0 bits (84), Expect = 0.076
Identities = 38/174 (21%), Positives = 75/174 (43%), Gaps = 12/174 (6%)
Query: 346 EQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRR 405
++ + +LQ R+E+ +EE + E++ D +E + RL E ++
Sbjct: 1109 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1168
Query: 406 QYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKR--QNAEMQ 463
+ E E +++R L++A + E ++ +K E+ Q N++R Q E +
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAA----TLRKKHADSVAELGEQIDNLQRVKQKLEKE 1224
Query: 464 LAIAKDEAEKIKKKRSTVF---GTLHV---AHSSSLDEVDHKILEAKKALSELT 511
+ K E + + TV G L A L E+ K E ++ +++LT
Sbjct: 1225 KSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLT 1278
Score = 35.4 bits (80), Expect = 0.22
Identities = 46/214 (21%), Positives = 94/214 (43%), Gaps = 39/214 (18%)
Query: 321 AYTQNKTSKEHVAKMMKDLESLQTAEQSL----MDLQERLEKAQEENRNVAVEKQNLERK 376
A T K + VA++ + +++LQ +Q L +++ ++ V+ K NLE+
Sbjct: 1193 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKM 1252
Query: 377 ------MMDEINYAKEEACRL-------------------REL--REGAECELSR-RQYA 408
+ EI +EE RL R+L ++ +LSR +Q
Sbjct: 1253 CRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAF 1312
Query: 409 EQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAK 468
Q++E+++ L++ E+++ ++ ALQ + QY + AE+Q A++K
Sbjct: 1313 TQQIEELKRQLEE-----EIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367
Query: 469 DEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKILE 502
+E + + T + T + + L+E K+ +
Sbjct: 1368 ANSEVAQWR--TKYETDAIQRTEELEEAKKKLAQ 1399
Score = 34.7 bits (78), Expect = 0.38
Identities = 45/201 (22%), Positives = 89/201 (44%), Gaps = 24/201 (11%)
Query: 328 SKEHVAKMMKDLE-SLQTAEQSLMDLQERLEK-------AQEENRNVAVEKQNLERKMMD 379
+K + + + DLE SL+ ++ MDL+ K AQE ++ +KQ L+ K+
Sbjct: 1027 AKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKK 1086
Query: 380 --------EINYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSS 431
+ E+A ++ ++ E + +R + E+E+E R + KAEK+ RS
Sbjct: 1087 KEFEMSGLQSKIEDEQALGMQLQKKIKELQ-ARIEELEEEIEAERASRAKAEKQ---RSD 1142
Query: 432 WS--VPDALQKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAH 489
S + + ++ + Q K++ AE Q + + E+ + TL H
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQK--MRRDLEEATLQHEATAATLRKKH 1200
Query: 490 SSSLDEVDHKILEAKKALSEL 510
+ S+ E+ +I ++ +L
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKL 1221
Score = 34.7 bits (78), Expect = 0.38
Identities = 44/204 (21%), Positives = 88/204 (43%), Gaps = 20/204 (9%)
Query: 341 SLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLE----------RKMMDEINYAKEEACR 390
S + AEQ L+D ER++ +N ++ K+ LE ++ E A+E+A +
Sbjct: 1702 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKK 1761
Query: 391 -LRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDAL-------QKWL 442
+ + AE EL + Q LE+++ L++ K+ + R + AL QK
Sbjct: 1762 AITDAAMMAE-ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1820
Query: 443 QLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSL-DEVDHKIL 501
E+E + + +++N E + K E + + T ++ L D++ K+
Sbjct: 1821 ARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1880
Query: 502 EAKKALSELTTCLRERLFRWQQIE 525
K+ E L ++++I+
Sbjct: 1881 SYKRQAEEAEEQSNVNLSKFRRIQ 1904
Score = 33.5 bits (75), Expect = 0.84
Identities = 40/192 (20%), Positives = 82/192 (42%), Gaps = 14/192 (7%)
Query: 328 SKEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEE 387
++EHV + SL+ +Q L + E L E N A + +++ D+I ++
Sbjct: 1404 AEEHVEAVNAKCASLEKTKQRLQNEVEDL-MIDVERTNAACAALDKKQRNFDKILAEWKQ 1462
Query: 388 ACRLRELREGAECELSR---------RQYAEQELEQVRMALKKAEKEFELRSSWSVPDAL 438
C A + SR + E+ L+Q+ LK+ K + S + + +
Sbjct: 1463 KCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLE-TLKRENKNLQQEIS-DLTEQI 1520
Query: 439 QKWLQLTHEVEVQYYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDH 498
+ + HE+E ++++ +E+Q A+ +EAE + + + + EVD
Sbjct: 1521 AEGGKRIHELEKIKKQVEQEKSELQAAL--EEAEASLEHEEGKILRIQLELNQVKSEVDR 1578
Query: 499 KILEAKKALSEL 510
KI E + + ++
Sbjct: 1579 KIAEKDEEIDQM 1590
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 43.1 bits (100), Expect = 0.001
Identities = 79/391 (20%), Positives = 157/391 (40%), Gaps = 40/391 (10%)
Query: 156 LEALQTIHKQMDDDKDGGIEVEESDEFIREDMKYKDATNKHSHLHREDKHITIEDLWKRW 215
L+ + Q+ ++D + EE + + ++ +A K + ED+ +L +
Sbjct: 881 LQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKK 940
Query: 216 KTSEVHNWTLEDTLQWLIEFVELPQYEKNFRDNNVKGTTLPRIAVHEP-SFMISQLKISD 274
+ E L+ + L + + EK+ +N VK T + E + + + K
Sbjct: 941 RKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 275 RSHRQKLQLKALDVVLFGPLTRPPHNWMKDFILTVSIVIGVGGCWFAYTQNKTSKEHVAK 334
+H+Q L + LT+ V + V + Q K + + +
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAK----------VKLEQQVDDLEGSLEQEKKVRMDLER 1050
Query: 335 MMKDLES-LQTAEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRE 393
+ LE L+ ++S+MDL+ ++ E + E L ++ DE + +L+E
Sbjct: 1051 AKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Query: 394 LREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWS--VPDALQKWLQLTHEVEVQ 451
L+ +R + E+ELE R A K EK LRS S + + ++ + VQ
Sbjct: 1111 LQ-------ARIEELEEELEAERTARAKVEK---LRSDLSRELEEISERLEEAGGATSVQ 1160
Query: 452 YYNIKRQNAEMQLAIAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVDHKI---------LE 502
K++ AE Q + + E+ + L H+ S+ E+ +I LE
Sbjct: 1161 IEMNKKREAEFQK--MRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE 1218
Query: 503 AKKA-----LSELTTCLRERLFRWQQIEKIC 528
+K+ L ++T+ + + + +EK+C
Sbjct: 1219 KEKSEFKLELDDVTSNMEQIIKAKANLEKMC 1249
Score = 37.0 bits (84), Expect = 0.076
Identities = 36/150 (24%), Positives = 67/150 (44%), Gaps = 23/150 (15%)
Query: 322 YTQNKTSKEHVAKMMKDLESLQT-AEQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDE 380
++QN + KM DL LQT E+++ + + EKA++ + A+ M +E
Sbjct: 1717 HSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAM--------MAEE 1768
Query: 381 INYAKEEACRLRELREGAECELSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDALQK 440
+ ++ + L +++ E + Q+ E EQ+ ALK +K+ LQK
Sbjct: 1769 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI--ALKGGKKQ------------LQK 1814
Query: 441 WLQLTHEVEVQYYNIKRQNAEMQLAIAKDE 470
E+E + +++NAE + K E
Sbjct: 1815 LEARVRELENELEAEQKRNAESVKGMRKSE 1844
Score = 33.9 bits (76), Expect = 0.64
Identities = 44/204 (21%), Positives = 87/204 (42%), Gaps = 24/204 (11%)
Query: 329 KEHVAKMMKDLESLQTAEQSLMDLQERLEKAQEEN----RNVAVEKQNLERKMMD---EI 381
K+ + +LES Q +SL +L+ A EE+ E +NL+ ++ D ++
Sbjct: 1457 KQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQL 1516
Query: 382 NYAKEEACRLRELREGAECE----LSRRQYAEQELEQVRMALKKAEKEFELRSSWSVPDA 437
+ + L ++R+ E E S + AE LE + +A+ EF + +
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA----EI 1572
Query: 438 LQKWLQLTHEVEVQYYNIKRQNAEMQLAI-----AKDEAEKIKKKRSTVFGTLHVAHSSS 492
+K + E+E N R +Q ++ +++EA ++KKK + +
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEI----Q 1628
Query: 493 LDEVDHKILEAKKALSELTTCLRE 516
L + EA+K + L + L++
Sbjct: 1629 LSHANRMAAEAQKQVKSLQSLLKD 1652
Score = 32.7 bits (73), Expect = 1.4
Identities = 34/176 (19%), Positives = 70/176 (39%), Gaps = 27/176 (15%)
Query: 346 EQSLMDLQERLEKAQEENRNVAVEKQNLERKMMDEINYAKEEACRLRELREGAECELSRR 405
++ L +LQ R+E+ +EE + +E+ D +E + RL E ++
Sbjct: 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Query: 406 QYAEQELEQVRMALKKAEKEFELRSSWSVPDALQKWLQLTHEVEVQYYNIKRQNAEMQLA 465
+ E E +++R L++A L HE K ++ +L
Sbjct: 1165 KKREAEFQKMRRDLEEA--------------------TLQHEATAAALRKKHADSVAELG 1204
Query: 466 IAKDEAEKIKKKRSTVFGTLHVAHSSSLDEVD---HKILEAKKALSELTTCLRERL 518
D +++K+K + LD+V +I++AK L ++ L +++
Sbjct: 1205 EQIDNLQRVKQKLEKEKSEFKL----ELDDVTSNMEQIIKAKANLEKMCRTLEDQM 1256
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,725,275
Number of Sequences: 37866
Number of extensions: 1980599
Number of successful extensions: 12933
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 139
Number of HSP's successfully gapped in prelim test: 719
Number of HSP's that attempted gapping in prelim test: 10062
Number of HSP's gapped (non-prelim): 3044
length of query: 833
length of database: 18,247,518
effective HSP length: 111
effective length of query: 722
effective length of database: 14,044,392
effective search space: 10140051024
effective search space used: 10140051024
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.