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Search of human proteins with 41349437
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41349437 bone morphogenetic protein receptor, type IA
precursor [Homo sapiens]
(532 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41349437 bone morphogenetic protein receptor, type IA precurs... 1095 0.0
gi|4502431 bone morphogenetic protein receptor, type IB precurso... 750 0.0
gi|4759226 transforming growth factor, beta receptor I isoform 1... 487 e-137
gi|166235898 activin A receptor, type I precursor [Homo sapiens] 461 e-129
gi|4501895 activin A receptor, type I precursor [Homo sapiens] 461 e-129
gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens] 459 e-129
gi|4757720 activin A receptor, type IB isoform a precursor [Homo... 459 e-129
gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens] 446 e-125
gi|195963412 transforming growth factor, beta receptor I isoform... 436 e-122
gi|116734714 activin A receptor type II-like 1 [Homo sapiens] 424 e-119
gi|116734712 activin A receptor type II-like 1 [Homo sapiens] 424 e-119
gi|33598910 activin A receptor, type IB isoform b precursor [Hom... 413 e-115
gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens] 412 e-115
gi|33598912 activin A receptor, type IB isoform c precursor [Hom... 355 6e-98
gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens] 300 2e-81
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 246 3e-65
gi|67782324 transforming growth factor, beta receptor II isoform... 210 2e-54
gi|67782326 transforming growth factor, beta receptor II isoform... 210 2e-54
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 210 3e-54
gi|15451916 bone morphogenetic protein receptor type II precurso... 203 3e-52
gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens] 152 6e-37
gi|187475373 c-src tyrosine kinase [Homo sapiens] 97 4e-20
gi|4758078 c-src tyrosine kinase [Homo sapiens] 97 4e-20
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 95 2e-19
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 95 2e-19
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 92 9e-19
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 90 6e-18
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 87 3e-17
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 87 3e-17
gi|33188459 B-Raf [Homo sapiens] 87 4e-17
>gi|41349437 bone morphogenetic protein receptor, type IA precursor
[Homo sapiens]
Length = 532
Score = 1095 bits (2831), Expect = 0.0
Identities = 532/532 (100%), Positives = 532/532 (100%)
Query: 1 MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK 60
MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK
Sbjct: 1 MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK 60
Query: 61 CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR 120
CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR
Sbjct: 61 CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR 120
Query: 121 TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC 180
TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC
Sbjct: 121 TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC 180
Query: 181 KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV 240
KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV
Sbjct: 181 KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV 240
Query: 241 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG 300
GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG
Sbjct: 241 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG 300
Query: 301 SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH 360
SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH
Sbjct: 301 SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH 360
Query: 361 RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN 420
RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN
Sbjct: 361 RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN 420
Query: 421 HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR 480
HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR
Sbjct: 421 HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR 480
Query: 481 PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI 532
PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
Sbjct: 481 PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI 532
>gi|4502431 bone morphogenetic protein receptor, type IB precursor
[Homo sapiens]
Length = 502
Score = 750 bits (1937), Expect = 0.0
Identities = 360/491 (73%), Positives = 415/491 (84%), Gaps = 3/491 (0%)
Query: 43 KSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMK 102
K E+G + AP L+C C HCP+D++NN C T+G+CF +IEEDD G + SGC+
Sbjct: 14 KKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLG 73
Query: 103 YEGSDFQCKDSPKAQLRRTIECC-RTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMA 161
EGSDFQC+D+P RR+IECC N CN+ L PTLPP+ F DG I LLIS+
Sbjct: 74 LEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVT 133
Query: 162 VCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSG 221
VC + +++ FCY Y K +R RY+ LEQDE +IP GESL+DLI+QSQSSGSGSG
Sbjct: 134 VCSLLLVLII-LFCYFRY-KRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSG 191
Query: 222 LPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTV 281
LPLLVQRTIAKQIQMV+Q+GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTV
Sbjct: 192 LPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTV 251
Query: 282 LMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACG 341
LMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYD+LK TLD +++LKLAYS+ G
Sbjct: 252 LMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSG 311
Query: 342 LCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTR 401
LCHLHTEI+ TQGKPAIAHRDLKSKNIL+KKNG+CCIADLGLAVKF SDTNEVD+P NTR
Sbjct: 312 LCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTR 371
Query: 402 VGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMV 461
VGTKRYM PEVLDESLN+NHFQ YIMAD+YSFGLI+WE+ARRC++GGIVEEYQLPY+++V
Sbjct: 372 VGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLV 431
Query: 462 PSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL 521
PSDPSYEDMRE+VC+K+LRP NRW+SDECLR + KLM+ECWAHNPASRLTALR+KKTL
Sbjct: 432 PSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL 491
Query: 522 AKMVESQDVKI 532
AKM ESQD+K+
Sbjct: 492 AKMSESQDIKL 502
>gi|4759226 transforming growth factor, beta receptor I isoform 1
precursor [Homo sapiens]
Length = 503
Score = 487 bits (1253), Expect = e-137
Identities = 255/485 (52%), Positives = 322/485 (66%), Gaps = 26/485 (5%)
Query: 59 LKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQ----GETTLASGCMKYEGSDFQCKDSP 114
L+C+C C D N TC+T+G CF + E +A + F C S
Sbjct: 34 LQCFCH-LCTKD--NFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSS 90
Query: 115 KAQLRRTIECCRTNLCNQYLQPT-------LPPVVIGPFFDGSIRWLVLLISMAVCIIAM 167
K T CC + CN+ PT L PV + G + + VCI M
Sbjct: 91 KTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCF--------VCISLM 142
Query: 168 IIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQ 227
++ C H I R D D FI G +LKDLI +SGSGSGLPLLVQ
Sbjct: 143 LMVYIC----HNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQ 198
Query: 228 RTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHEN 287
RTIA+ I + +GKGR+GEVW GKWRGE+VAVK+F + EE SWFRE EIYQTV++RHEN
Sbjct: 199 RTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHEN 258
Query: 288 ILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHT 347
ILGFIAAD K G+WTQL+L++DYHE+GSL+D+L T+ ++KLA S A GL HLH
Sbjct: 259 ILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHM 318
Query: 348 EIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRY 407
EI GTQGKPAIAHRDLKSKNIL+KKNG+CCIADLGLAV+ +S T+ +D+ N RVGTKRY
Sbjct: 319 EIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRY 378
Query: 408 MAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSY 467
MAPEVLD+S+N HF+ + ADIY+ GL+ WE+ARRC GGI E+YQLPYY++VPSDPS
Sbjct: 379 MAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSV 438
Query: 468 EDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVES 527
E+MR+VVC ++LRP + NRW S E LR + K+M ECW N A+RLTALRIKKTL+++ +
Sbjct: 439 EEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQ 498
Query: 528 QDVKI 532
+ +K+
Sbjct: 499 EGIKM 503
>gi|166235898 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 461 bits (1185), Expect = e-129
Identities = 243/460 (52%), Positives = 318/460 (69%), Gaps = 21/460 (4%)
Query: 82 CFAIIEEDDQGETTLASGCMK-YEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPP 140
CF+ + +D G GC + YE CK P + +ECC+ + CN+ + LP
Sbjct: 53 CFSSLSIND-GFHVYQKGCFQVYEQGKMTCKTPPSPG--QAVECCQGDWCNRNITAQLPT 109
Query: 141 VVIGPFFDGS------IRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLE 194
G F G+ + ++L + AVC++A ++ + +K + R RD+E
Sbjct: 110 K--GKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRR----NQERLNPRDVE 163
Query: 195 QD--EAFIP--VGES-LKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVW 249
E I VG+S L DL+D S +SGSGSGLP LVQRT+A+QI ++ VGKGRYGEVW
Sbjct: 164 YGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVW 223
Query: 250 MGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLIT 309
G W+GE VAVK+F + +E SWFRETE+Y TV++RHENILGFIA+D+ S TQL+LIT
Sbjct: 224 RGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLIT 283
Query: 310 DYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNIL 369
YHE GSLYD+L+ TLDT + L++ S A GL HLH EI+GTQGKPAIAHRDLKSKNIL
Sbjct: 284 HYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNIL 343
Query: 370 IKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMAD 429
+KKNG CCIADLGLAV + TN++DV N RVGTKRYMAPEVLDE++ + F Y D
Sbjct: 344 VKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVD 403
Query: 430 IYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNS 489
I++FGL++WE+ARR ++ GIVE+Y+ P+Y++VP+DPS+EDMR+VVCV + RP + NRW S
Sbjct: 404 IWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFS 463
Query: 490 DECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQD 529
D L ++ KLM ECW NP++RLTALRIKKTL K+ S D
Sbjct: 464 DPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLD 503
>gi|4501895 activin A receptor, type I precursor [Homo sapiens]
Length = 509
Score = 461 bits (1185), Expect = e-129
Identities = 243/460 (52%), Positives = 318/460 (69%), Gaps = 21/460 (4%)
Query: 82 CFAIIEEDDQGETTLASGCMK-YEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPP 140
CF+ + +D G GC + YE CK P + +ECC+ + CN+ + LP
Sbjct: 53 CFSSLSIND-GFHVYQKGCFQVYEQGKMTCKTPPSPG--QAVECCQGDWCNRNITAQLPT 109
Query: 141 VVIGPFFDGS------IRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLE 194
G F G+ + ++L + AVC++A ++ + +K + R RD+E
Sbjct: 110 K--GKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRR----NQERLNPRDVE 163
Query: 195 QD--EAFIP--VGES-LKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVW 249
E I VG+S L DL+D S +SGSGSGLP LVQRT+A+QI ++ VGKGRYGEVW
Sbjct: 164 YGTIEGLITTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVW 223
Query: 250 MGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLIT 309
G W+GE VAVK+F + +E SWFRETE+Y TV++RHENILGFIA+D+ S TQL+LIT
Sbjct: 224 RGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLIT 283
Query: 310 DYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNIL 369
YHE GSLYD+L+ TLDT + L++ S A GL HLH EI+GTQGKPAIAHRDLKSKNIL
Sbjct: 284 HYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNIL 343
Query: 370 IKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMAD 429
+KKNG CCIADLGLAV + TN++DV N RVGTKRYMAPEVLDE++ + F Y D
Sbjct: 344 VKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVD 403
Query: 430 IYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNS 489
I++FGL++WE+ARR ++ GIVE+Y+ P+Y++VP+DPS+EDMR+VVCV + RP + NRW S
Sbjct: 404 IWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFS 463
Query: 490 DECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQD 529
D L ++ KLM ECW NP++RLTALRIKKTL K+ S D
Sbjct: 464 DPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLD 503
>gi|161333833 activin A receptor, type IC isoform 1 [Homo sapiens]
Length = 493
Score = 459 bits (1181), Expect = e-129
Identities = 248/487 (50%), Positives = 326/487 (66%), Gaps = 18/487 (3%)
Query: 51 APEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQC 110
A + P LKC C C D+ N TC T G C+A + + E + S C+ + Q
Sbjct: 18 AAAELSPGLKCVCL-LC--DSSNFTCQTEGACWASVMLTNGKEQVIKS-CVSLPELNAQV 73
Query: 111 KDSPKAQLRRTIECCRTNLCNQYLQ--PTLPPVV--IGPFFDGSIRWLVLLISMAVCIIA 166
+ +T ECC T+ CN PT P +GP L ++I++ VC+++
Sbjct: 74 FCHSSNNVTKT-ECCFTDFCNNITLHLPTASPNAPKLGPME------LAIIITVPVCLLS 126
Query: 167 MIIFSSCF-CYKHYCKSISSRRRYNRDLEQDEA-FIPVGESLKDLIDQSQSSGSGSGLPL 224
+ + + C C S ++R N + E + G++LKDLI +SGSGSGLPL
Sbjct: 127 IAAMLTVWACQGRQC-SYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPL 185
Query: 225 LVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMR 284
LVQRTIA+ I + VGKGR+GEVW G+W GE VAVK+F + +E SWFRE EIYQTV++R
Sbjct: 186 LVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLR 245
Query: 285 HENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCH 344
HENILGFIAAD K G+WTQL+L+++YHE GSLYD+L + ++KLA S A GL H
Sbjct: 246 HENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAH 305
Query: 345 LHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGT 404
LH EI GTQGKPAIAHRD+KSKNIL+KK +C IADLGLAVK +S N +D+P N +VGT
Sbjct: 306 LHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGT 365
Query: 405 KRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSD 464
KRYMAPE+LD+++N N F+ + ADIYS GL+ WE+ARRC GGIVEEYQLPYY+MVPSD
Sbjct: 366 KRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSD 425
Query: 465 PSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524
PS E+MR+VVC ++ RP + N+W S E LR + ++M ECW N A+RLTALRIKKT++++
Sbjct: 426 PSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQL 485
Query: 525 VESQDVK 531
+D K
Sbjct: 486 CVKEDCK 492
>gi|4757720 activin A receptor, type IB isoform a precursor [Homo
sapiens]
Length = 505
Score = 459 bits (1180), Expect = e-129
Identities = 243/473 (51%), Positives = 319/473 (67%), Gaps = 23/473 (4%)
Query: 73 NNTCITNGHCFAIIEEDDQGETTLASGCMKYE----GSDFQCKDSPKAQLRRTIECCRTN 128
N TC T+G C I D E + + K E G F C S LR T CC T+
Sbjct: 43 NYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE--DLRNT-HCCYTD 99
Query: 129 LCNQ--------YLQPTLPPVVIGPF-FDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHY 179
CN+ +L+ P + GP G I V L+ + + I+ ++I ++
Sbjct: 100 YCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVI-------NYH 152
Query: 180 CKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQ 239
+ +R+R + + E + ++L+DL+ +SGSGSGLPL VQRT+A+ I +
Sbjct: 153 QRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI 212
Query: 240 VGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGT 299
+GKGR+GEVW G+WRG VAVK+F + EE SWFRE EIYQTV++RHENILGFIAAD K
Sbjct: 213 IGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN 272
Query: 300 GSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIA 359
G+WTQL+L++DYHE+GSL+D+L T+ ++KLA SAA GL HLH EI GTQGKP IA
Sbjct: 273 GTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIA 332
Query: 360 HRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNK 419
HRDLKSKNIL+KKNG C IADLGLAV+ ++ T+ +D+ N RVGTKRYMAPEVLDE++N
Sbjct: 333 HRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINM 392
Query: 420 NHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRL 479
HF + ADIY+ GL+ WE+ARRC +GG+ EEYQLPYY++VPSDPS E+MR+VVC ++L
Sbjct: 393 KHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKL 452
Query: 480 RPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI 532
RP + N W S E LR + K+M ECW N A+RLTALRIKKTL+++ +DVKI
Sbjct: 453 RPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI 505
>gi|161333835 activin A receptor, type IC isoform 2 [Homo sapiens]
Length = 443
Score = 446 bits (1148), Expect = e-125
Identities = 228/415 (54%), Positives = 296/415 (71%), Gaps = 13/415 (3%)
Query: 123 ECCRTNLCNQYLQ--PTLPPVV--IGPFFDGSIRWLVLLISMAVCIIAMIIFSSCF-CYK 177
ECC T+ CN PT P +GP L ++I++ VC++++ + + C
Sbjct: 35 ECCFTDFCNNITLHLPTASPNAPKLGPME------LAIIITVPVCLLSIAAMLTVWACQG 88
Query: 178 HYCKSISSRRRYNRDLEQDEA-FIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQM 236
C S ++R N + E + G++LKDLI +SGSGSGLPLLVQRTIA+ I +
Sbjct: 89 RQC-SYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVL 147
Query: 237 VRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADI 296
VGKGR+GEVW G+W GE VAVK+F + +E SWFRE EIYQTV++RHENILGFIAAD
Sbjct: 148 QEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADN 207
Query: 297 KGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKP 356
K G+WTQL+L+++YHE GSLYD+L + ++KLA S A GL HLH EI GTQGKP
Sbjct: 208 KDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKP 267
Query: 357 AIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDES 416
AIAHRD+KSKNIL+KK +C IADLGLAVK +S N +D+P N +VGTKRYMAPE+LD++
Sbjct: 268 AIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDT 327
Query: 417 LNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCV 476
+N N F+ + ADIYS GL+ WE+ARRC GGIVEEYQLPYY+MVPSDPS E+MR+VVC
Sbjct: 328 MNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCD 387
Query: 477 KRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVK 531
++ RP + N+W S E LR + ++M ECW N A+RLTALRIKKT++++ +D K
Sbjct: 388 QKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 442
>gi|195963412 transforming growth factor, beta receptor I isoform 2
precursor [Homo sapiens]
Length = 426
Score = 436 bits (1121), Expect = e-122
Identities = 203/313 (64%), Positives = 255/313 (81%)
Query: 220 SGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQ 279
+GLPLLVQRTIA+ I + +GKGR+GEVW GKWRGE+VAVK+F + EE SWFRE EIYQ
Sbjct: 114 TGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQ 173
Query: 280 TVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAA 339
TV++RHENILGFIAAD K G+WTQL+L++DYHE+GSL+D+L T+ ++KLA S A
Sbjct: 174 TVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTA 233
Query: 340 CGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLN 399
GL HLH EI GTQGKPAIAHRDLKSKNIL+KKNG+CCIADLGLAV+ +S T+ +D+ N
Sbjct: 234 SGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 293
Query: 400 TRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYN 459
RVGTKRYMAPEVLD+S+N HF+ + ADIY+ GL+ WE+ARRC GGI E+YQLPYY+
Sbjct: 294 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYD 353
Query: 460 MVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKK 519
+VPSDPS E+MR+VVC ++LRP + NRW S E LR + K+M ECW N A+RLTALRIKK
Sbjct: 354 LVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 413
Query: 520 TLAKMVESQDVKI 532
TL+++ + + +K+
Sbjct: 414 TLSQLSQQEGIKM 426
Score = 36.2 bits (82), Expect = 0.077
Identities = 25/83 (30%), Positives = 34/83 (40%), Gaps = 7/83 (8%)
Query: 59 LKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQ----GETTLASGCMKYEGSDFQCKDSP 114
L+C+C C D N TC+T+G CF + E +A + F C S
Sbjct: 34 LQCFCH-LCTKD--NFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSS 90
Query: 115 KAQLRRTIECCRTNLCNQYLQPT 137
K T CC + CN+ PT
Sbjct: 91 KTGSVTTTYCCNQDHCNKIELPT 113
>gi|116734714 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 424 bits (1091), Expect = e-119
Identities = 227/482 (47%), Positives = 306/482 (63%), Gaps = 23/482 (4%)
Query: 57 PFLKCYC-SGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPK 115
P + C C S HC TC C ++ ++ GC C+ P
Sbjct: 30 PLVTCTCESPHCKGP----TC-RGAWCTVVLVREEGRHPQEHRGCGNLHRE--LCRGRPT 82
Query: 116 AQLRRTIECCRTNLCNQ----YLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFS 171
+ CC ++LCN L+ T PP P DG L L++ + ++A++
Sbjct: 83 EFVNHY--CCDSHLCNHNVSLVLEATQPPSE-QPGTDGQ---LALILGPVLALLALVALG 136
Query: 172 SCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGES----LKDLIDQSQSSGSGSGLPLLVQ 227
+ H + +R + +L + + E L DL+D ++GSGSGLP LVQ
Sbjct: 137 VLGLW-HVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQ 195
Query: 228 RTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHEN 287
RT+A+Q+ +V VGKGRYGEVW G W GE VAVK+F + +E SWFRETEIY TVL+RH+N
Sbjct: 196 RTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDN 255
Query: 288 ILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHT 347
ILGFIA+D+ S TQL+LIT YHE+GSLYDFL+ TL+ L+LA SAACGL HLH
Sbjct: 256 ILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHV 315
Query: 348 EIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRY 407
EI+GTQGKPAIAHRD KS+N+L+K N CCIADLGLAV + ++ +D+ N RVGTKRY
Sbjct: 316 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRY 375
Query: 408 MAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSY 467
MAPEVLDE + + F+ Y DI++FGL++WE+ARR I GIVE+Y+ P+Y++VP+DPS+
Sbjct: 376 MAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSF 435
Query: 468 EDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVES 527
EDM++VVCV + P + NR +D L + ++M ECW NP++RLTALRIKKTL K+ S
Sbjct: 436 EDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNS 495
Query: 528 QD 529
+
Sbjct: 496 PE 497
>gi|116734712 activin A receptor type II-like 1 [Homo sapiens]
Length = 503
Score = 424 bits (1091), Expect = e-119
Identities = 227/482 (47%), Positives = 306/482 (63%), Gaps = 23/482 (4%)
Query: 57 PFLKCYC-SGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPK 115
P + C C S HC TC C ++ ++ GC C+ P
Sbjct: 30 PLVTCTCESPHCKGP----TC-RGAWCTVVLVREEGRHPQEHRGCGNLHRE--LCRGRPT 82
Query: 116 AQLRRTIECCRTNLCNQ----YLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFS 171
+ CC ++LCN L+ T PP P DG L L++ + ++A++
Sbjct: 83 EFVNHY--CCDSHLCNHNVSLVLEATQPPSE-QPGTDGQ---LALILGPVLALLALVALG 136
Query: 172 SCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGES----LKDLIDQSQSSGSGSGLPLLVQ 227
+ H + +R + +L + + E L DL+D ++GSGSGLP LVQ
Sbjct: 137 VLGLW-HVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQ 195
Query: 228 RTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHEN 287
RT+A+Q+ +V VGKGRYGEVW G W GE VAVK+F + +E SWFRETEIY TVL+RH+N
Sbjct: 196 RTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDN 255
Query: 288 ILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHT 347
ILGFIA+D+ S TQL+LIT YHE+GSLYDFL+ TL+ L+LA SAACGL HLH
Sbjct: 256 ILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHV 315
Query: 348 EIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRY 407
EI+GTQGKPAIAHRD KS+N+L+K N CCIADLGLAV + ++ +D+ N RVGTKRY
Sbjct: 316 EIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRY 375
Query: 408 MAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSY 467
MAPEVLDE + + F+ Y DI++FGL++WE+ARR I GIVE+Y+ P+Y++VP+DPS+
Sbjct: 376 MAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSF 435
Query: 468 EDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVES 527
EDM++VVCV + P + NR +D L + ++M ECW NP++RLTALRIKKTL K+ S
Sbjct: 436 EDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNS 495
Query: 528 QD 529
+
Sbjct: 496 PE 497
>gi|33598910 activin A receptor, type IB isoform b precursor [Homo
sapiens]
Length = 476
Score = 413 bits (1062), Expect = e-115
Identities = 219/432 (50%), Positives = 288/432 (66%), Gaps = 23/432 (5%)
Query: 73 NNTCITNGHCFAIIEEDDQGETTLASGCMKYE----GSDFQCKDSPKAQLRRTIECCRTN 128
N TC T+G C I D E + + K E G F C S LR T CC T+
Sbjct: 43 NYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE--DLRNT-HCCYTD 99
Query: 129 LCNQ--------YLQPTLPPVVIGPF-FDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHY 179
CN+ +L+ P + GP G I V L+ + + I+ ++I ++
Sbjct: 100 YCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVI-------NYH 152
Query: 180 CKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQ 239
+ +R+R + + E + ++L+DL+ +SGSGSGLPL VQRT+A+ I +
Sbjct: 153 QRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI 212
Query: 240 VGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGT 299
+GKGR+GEVW G+WRG VAVK+F + EE SWFRE EIYQTV++RHENILGFIAAD K
Sbjct: 213 IGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN 272
Query: 300 GSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIA 359
G+WTQL+L++DYHE+GSL+D+L T+ ++KLA SAA GL HLH EI GTQGKP IA
Sbjct: 273 GTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIA 332
Query: 360 HRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNK 419
HRDLKSKNIL+KKNG C IADLGLAV+ ++ T+ +D+ N RVGTKRYMAPEVLDE++N
Sbjct: 333 HRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINM 392
Query: 420 NHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRL 479
HF + ADIY+ GL+ WE+ARRC +GG+ EEYQLPYY++VPSDPS E+MR+VVC ++L
Sbjct: 393 KHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKL 452
Query: 480 RPIVSNRWNSDE 491
RP + N W S E
Sbjct: 453 RPNIPNWWQSYE 464
>gi|161333837 activin A receptor, type IC isoform 3 [Homo sapiens]
Length = 413
Score = 412 bits (1059), Expect = e-115
Identities = 196/312 (62%), Positives = 246/312 (78%)
Query: 220 SGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQ 279
+GLPLLVQRTIA+ I + VGKGR+GEVW G+W GE VAVK+F + +E SWFRE EIYQ
Sbjct: 101 TGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQ 160
Query: 280 TVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAA 339
TV++RHENILGFIAAD K G+WTQL+L+++YHE GSLYD+L + ++KLA S A
Sbjct: 161 TVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIA 220
Query: 340 CGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLN 399
GL HLH EI GTQGKPAIAHRD+KSKNIL+KK +C IADLGLAVK +S N +D+P N
Sbjct: 221 SGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQN 280
Query: 400 TRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYN 459
+VGTKRYMAPE+LD+++N N F+ + ADIYS GL+ WE+ARRC GGIVEEYQLPYY+
Sbjct: 281 PKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYD 340
Query: 460 MVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKK 519
MVPSDPS E+MR+VVC ++ RP + N+W S E LR + ++M ECW N A+RLTALRIKK
Sbjct: 341 MVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKK 400
Query: 520 TLAKMVESQDVK 531
T++++ +D K
Sbjct: 401 TISQLCVKEDCK 412
Score = 33.5 bits (75), Expect = 0.50
Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 8/95 (8%)
Query: 51 APEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQC 110
A + P LKC C C D+ N TC T G C+A + + G+ + C+ + Q
Sbjct: 18 AAAELSPGLKCVCL-LC--DSSNFTCQTEGACWASVMLTN-GKEQVIKSCVSLPELNAQV 73
Query: 111 KDSPKAQLRRTIECCRTNLCNQ---YLQPTLPPVV 142
+ +T ECC T+ CN +L LP +V
Sbjct: 74 FCHSSNNVTKT-ECCFTDFCNNITLHLPTGLPLLV 107
>gi|33598912 activin A receptor, type IB isoform c precursor [Homo
sapiens]
Length = 487
Score = 355 bits (911), Expect = 6e-98
Identities = 192/389 (49%), Positives = 253/389 (65%), Gaps = 23/389 (5%)
Query: 73 NNTCITNGHCFAIIEEDDQGETTLASGCMKYE----GSDFQCKDSPKAQLRRTIECCRTN 128
N TC T+G C I D E + + K E G F C S LR T CC T+
Sbjct: 43 NYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSE--DLRNT-HCCYTD 99
Query: 129 LCNQ--------YLQPTLPPVVIGPF-FDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHY 179
CN+ +L+ P + GP G I V L+ + + I+ ++I ++
Sbjct: 100 YCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVI-------NYH 152
Query: 180 CKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQ 239
+ +R+R + + E + ++L+DL+ +SGSGSGLPL VQRT+A+ I +
Sbjct: 153 QRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEI 212
Query: 240 VGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGT 299
+GKGR+GEVW G+WRG VAVK+F + EE SWFRE EIYQTV++RHENILGFIAAD K
Sbjct: 213 IGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN 272
Query: 300 GSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIA 359
G+WTQL+L++DYHE+GSL+D+L T+ ++KLA SAA GL HLH EI GTQGKP IA
Sbjct: 273 GTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIA 332
Query: 360 HRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNK 419
HRDLKSKNIL+KKNG C IADLGLAV+ ++ T+ +D+ N RVGTKRYMAPEVLDE++N
Sbjct: 333 HRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINM 392
Query: 420 NHFQPYIMADIYSFGLIIWEMARRCITGG 448
HF + ADIY+ GL+ WE+ARRC +GG
Sbjct: 393 KHFDSFKCADIYALGLVYWEIARRCNSGG 421
>gi|161333839 activin A receptor, type IC isoform 4 [Homo sapiens]
Length = 336
Score = 300 bits (769), Expect = 2e-81
Identities = 141/232 (60%), Positives = 181/232 (78%)
Query: 300 GSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIA 359
G+WTQL+L+++YHE GSLYD+L + ++KLA S A GL HLH EI GTQGKPAIA
Sbjct: 104 GTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIA 163
Query: 360 HRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNK 419
HRD+KSKNIL+KK +C IADLGLAVK +S N +D+P N +VGTKRYMAPE+LD+++N
Sbjct: 164 HRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNV 223
Query: 420 NHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRL 479
N F+ + ADIYS GL+ WE+ARRC GGIVEEYQLPYY+MVPSDPS E+MR+VVC ++
Sbjct: 224 NIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKF 283
Query: 480 RPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVK 531
RP + N+W S E LR + ++M ECW N A+RLTALRIKKT++++ +D K
Sbjct: 284 RPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCK 335
Score = 33.1 bits (74), Expect = 0.65
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 5/81 (6%)
Query: 51 APEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQC 110
A + P LKC C C D+ N TC T G C+A + + G+ + C+ + Q
Sbjct: 18 AAAELSPGLKCVCL-LC--DSSNFTCQTEGACWASVMLTN-GKEQVIKSCVSLPELNAQV 73
Query: 111 KDSPKAQLRRTIECCRTNLCN 131
+ +T ECC T+ CN
Sbjct: 74 FCHSSNNVTKT-ECCFTDFCN 93
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 246 bits (629), Expect = 3e-65
Identities = 161/463 (34%), Positives = 244/463 (52%), Gaps = 58/463 (12%)
Query: 81 HCFAIIEEDDQGETTLASGCMK-----YEGSD-FQCKDSPKAQLRRTIECCRTNLCNQYL 134
HCFA + + GC Y+ +D + KDSP+ CC N+CN+
Sbjct: 59 HCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFC----CCEGNMCNEKF 114
Query: 135 ---------QPTLPPVVIGPFFDGSIRWLVLLISMA-VCIIAMIIFSSCFCYKHYCKSIS 184
QPT PV P + + +LL S+ + +IA I+ + + Y+H+
Sbjct: 115 SYFPEMEVTQPTSNPVTPKPPY-----YNILLYSLVPLMLIAGIVICAFWVYRHH----- 164
Query: 185 SRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGR 244
A+ PV + +Q G PLL K +Q++ +GR
Sbjct: 165 -----------KMAYPPV-------LVPTQDPGPPPPSPLLG----LKPLQLLEVKARGR 202
Query: 245 YGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQ 304
+G VW + E VAVK+F ++ SW E E+Y M+HENIL FI A+ +GT
Sbjct: 203 FGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVD 262
Query: 305 LYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQG--KPAIAHRD 362
L+LIT +HE GSL DFLK + L +A + A GL +LH +I G + KPAI+HRD
Sbjct: 263 LWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRD 322
Query: 363 LKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHF 422
+KSKN+L+K N + CIAD GLA+KF + + D + +VGT+RYMAPEVL+ ++N
Sbjct: 323 IKSKNVLLKNNLTACIADFGLALKFEAGKSAGDT--HGQVGTRRYMAPEVLEGAINFQR- 379
Query: 423 QPYIMADIYSFGLIIWEMARRCITG-GIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRP 481
++ D+Y+ GL++WE+A RC G V+EY LP+ + PS EDM+EVV K+ RP
Sbjct: 380 DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRP 439
Query: 482 IVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524
++ + W + + + + ECW H+ +RL+A + + + +M
Sbjct: 440 VLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQM 482
>gi|67782324 transforming growth factor, beta receptor II isoform B
precursor [Homo sapiens]
Length = 567
Score = 210 bits (535), Expect = 2e-54
Identities = 141/471 (29%), Positives = 243/471 (51%), Gaps = 41/471 (8%)
Query: 82 CFAIIEEDDQGETTLASGCM--KYEGSDFQCKD--SPKAQLRRTIE--------CCRTNL 129
C A+ ++D+ TL + C K DF +D SPK ++ + C ++
Sbjct: 84 CVAVWRKNDEN-ITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDE 142
Query: 130 CNQYL------QPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSI 183
CN + + P +++ F + + LL + V I +IIF YC +
Sbjct: 143 CNDNIIFSEEYNTSNPDLLLVIF---QVTGISLLPPLGVAISVIIIF--------YCYRV 191
Query: 184 SSRRRYNRDLEQDEA--FIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVG 241
+ +++ + E + + E +++ +S S + + T I++ VG
Sbjct: 192 NRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVG 251
Query: 242 KGRYGEVWMGKWRG------EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAAD 295
KGR+ EV+ K + E VAVK+F E ASW E +I+ + ++HENIL F+ A+
Sbjct: 252 KGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAE 311
Query: 296 IKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGK 355
+ T Q +LIT +H G+L ++L + L KL S A G+ HLH++ + G+
Sbjct: 312 ERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD-HTPCGR 370
Query: 356 PA--IAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVL 413
P I HRDLKS NIL+K + +CC+ D GL+++ + + D+ + +VGT RYMAPEVL
Sbjct: 371 PKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVL 430
Query: 414 DESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREV 473
+ +N + + + D+YS L++WEM RC G V++Y+ P+ + V P E M++
Sbjct: 431 ESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDN 490
Query: 474 VCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524
V R RP + + W + + ++ V + ++ECW H+P +RLTA + + +++
Sbjct: 491 VLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 541
>gi|67782326 transforming growth factor, beta receptor II isoform A
precursor [Homo sapiens]
Length = 592
Score = 210 bits (535), Expect = 2e-54
Identities = 141/471 (29%), Positives = 243/471 (51%), Gaps = 41/471 (8%)
Query: 82 CFAIIEEDDQGETTLASGCM--KYEGSDFQCKD--SPKAQLRRTIE--------CCRTNL 129
C A+ ++D+ TL + C K DF +D SPK ++ + C ++
Sbjct: 109 CVAVWRKNDEN-ITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDE 167
Query: 130 CNQYL------QPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSI 183
CN + + P +++ F + + LL + V I +IIF YC +
Sbjct: 168 CNDNIIFSEEYNTSNPDLLLVIF---QVTGISLLPPLGVAISVIIIF--------YCYRV 216
Query: 184 SSRRRYNRDLEQDEA--FIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVG 241
+ +++ + E + + E +++ +S S + + T I++ VG
Sbjct: 217 NRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVG 276
Query: 242 KGRYGEVWMGKWRG------EKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAAD 295
KGR+ EV+ K + E VAVK+F E ASW E +I+ + ++HENIL F+ A+
Sbjct: 277 KGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAE 336
Query: 296 IKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGK 355
+ T Q +LIT +H G+L ++L + L KL S A G+ HLH++ + G+
Sbjct: 337 ERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD-HTPCGR 395
Query: 356 PA--IAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVL 413
P I HRDLKS NIL+K + +CC+ D GL+++ + + D+ + +VGT RYMAPEVL
Sbjct: 396 PKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVL 455
Query: 414 DESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREV 473
+ +N + + + D+YS L++WEM RC G V++Y+ P+ + V P E M++
Sbjct: 456 ESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDN 515
Query: 474 VCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524
V R RP + + W + + ++ V + ++ECW H+P +RLTA + + +++
Sbjct: 516 VLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 566
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 210 bits (534), Expect = 3e-54
Identities = 111/287 (38%), Positives = 175/287 (60%), Gaps = 7/287 (2%)
Query: 232 KQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 291
K +Q++ +GR+G VW + + VAVK+F ++ SW E EI+ T M+HEN+L F
Sbjct: 188 KPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQF 247
Query: 292 IAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYG 351
IAA+ +G+ +L+LIT +H+ GSL D+LK + L +A + + GL +LH ++
Sbjct: 248 IAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPW 307
Query: 352 TQG---KPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYM 408
+G KP+IAHRD KSKN+L+K + + +AD GLAV+F D + +VGT+RYM
Sbjct: 308 CRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDT--HGQVGTRRYM 365
Query: 409 APEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRC-ITGGIVEEYQLPYYNMVPSDPSY 467
APEVL+ ++N ++ D+Y+ GL++WE+ RC G V+EY LP+ + PS
Sbjct: 366 APEVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSL 424
Query: 468 EDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTA 514
E+++EVV K++RP + + W L + + ECW H+ +RL+A
Sbjct: 425 EELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 471
>gi|15451916 bone morphogenetic protein receptor type II precursor
[Homo sapiens]
Length = 1038
Score = 203 bits (517), Expect = 3e-52
Identities = 136/473 (28%), Positives = 228/473 (48%), Gaps = 50/473 (10%)
Query: 76 CITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCK-------DSPKAQLRRTIE--CCR 126
C C+ + E+ + GC + G +C +P + T CC
Sbjct: 60 CSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCS 119
Query: 127 TNLCNQYLQPTLPP---VVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCKSI 183
T+LCN PP + P + +++ +V ++A++I + CF Y+
Sbjct: 120 TDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYR------ 173
Query: 184 SSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKG 243
+ G+ + L + + S L + ++++ +G+G
Sbjct: 174 ----------------MLTGDRKQGLHSMNMMEAAASEPSLDLDN-----LKLLELIGRG 212
Query: 244 RYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWT 303
RYG V+ G VAVKVF ++ E IY+ LM H+NI FI D + T
Sbjct: 213 RYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGR 272
Query: 304 QLY-LITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEI-YGTQGKPAIAHR 361
Y L+ +Y+ NGSL +L T D + +LA+S GL +LHTE+ G KPAI+HR
Sbjct: 273 MEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHR 332
Query: 362 DLKSKNILIKKNGSCCIADLGLAVKFNSD----TNEVDVPLNTRVGTKRYMAPEVLDESL 417
DL S+N+L+K +G+C I+D GL+++ + E D + VGT RYMAPEVL+ ++
Sbjct: 333 DLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAV 392
Query: 418 NKNHFQPYI-MADIYSFGLIIWEMARRC---ITGGIVEEYQLPYYNMVPSDPSYEDMREV 473
N + + D+Y+ GLI WE+ RC G V EYQ+ + V + P++EDM+ +
Sbjct: 393 NLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVL 452
Query: 474 VCVKRLRPIVSNRWNSDE-CLRAVLKLMSECWAHNPASRLTALRIKKTLAKMV 525
V ++ RP W + +R++ + + +CW + +RLTA ++ +A+++
Sbjct: 453 VSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELM 505
>gi|10198656 anti-Mullerian hormone receptor, type II [Homo sapiens]
Length = 573
Score = 152 bits (385), Expect = 6e-37
Identities = 132/486 (27%), Positives = 215/486 (44%), Gaps = 59/486 (12%)
Query: 76 CITNGHCFAIIEEDDQGETTLASGCMKYEG---SDFQCKDSPKAQLR---RTIEC-CRTN 128
C+ + CF I GC + C SP+A C C T+
Sbjct: 55 CLYSRCCFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTD 114
Query: 129 LCNQYLQPTLPPVVIGP-------FFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYCK 181
CN PP G G W+ L++ + + ++ +++ S
Sbjct: 115 FCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVL-LGLFLLLLLLLGSIIL------ 167
Query: 182 SISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVG 241
++ R+ Y E PV E D SG V+ ++ + +
Sbjct: 168 ALLQRKNYRVRGE------PVPEPRPD-----------SGRDWSVELQELPELCFSQVIR 210
Query: 242 KGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGS 301
+G + VW G+ +G+ VA+K F A + E +Y+ ++H++I+ FI A G G
Sbjct: 211 EGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGR 270
Query: 302 WTQ-LYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGT-QGKPAIA 359
L+ + H GSL +L T D + L++A S A GL LH E + Q KP IA
Sbjct: 271 LLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIA 330
Query: 360 HRDLKSKNILIKKNGSCCIADLGLAVKFN--------SDTNEVDVPLNTRVGTKRYMAPE 411
HRDL S+N+LI+++GSC I DLGLA+ + T GT+RYMAPE
Sbjct: 331 HRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPE 390
Query: 412 VLDESLNKNHFQPYI-MADIYSFGLIIWEMARRC---ITGGIVEEYQLPYYNMVPSDPSY 467
+LD++L+ + + ADIYS L++WE+ RC +QL Y + + P+
Sbjct: 391 LLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTS 450
Query: 468 EDMREVVCVKRLRPIVSNRWNSDECLR----AVLKLMSECWAHNPASRLTALRIKKTLAK 523
+++ + +R RP + + W C + +L+ +CW +P +RLTA +++ LA
Sbjct: 451 DELWALAVQERRRPYIPSTW---RCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAA 507
Query: 524 MVESQD 529
+ Q+
Sbjct: 508 LAHPQE 513
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 97.1 bits (240), Expect = 4e-20
Identities = 76/293 (25%), Positives = 136/293 (46%), Gaps = 48/293 (16%)
Query: 232 KQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 291
K++++++ +GKG +G+V +G +RG KVAVK A F T L RH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL-RHSNLVQL 251
Query: 292 IAADIKGTGSWTQLYLITDYHENGSLYDFLKC---ATLDTRALLKLAYSAACGLCHLHTE 348
+ ++ G LY++T+Y GSL D+L+ + L LLK + +C
Sbjct: 252 LGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD----VCEAMEY 304
Query: 349 IYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYM 408
+ G HRDL ++N+L+ ++ ++D GL + +S + +P+ ++
Sbjct: 305 LEGNN----FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV-------KWT 353
Query: 409 APEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYE 468
APE L E +D++SFG+++WE+ + G V ++P ++VP
Sbjct: 354 APEALREKKFSTK------SDVWSFGILLWEI----YSFGRVPYPRIPLKDVVPRVEKGY 403
Query: 469 DMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL 521
M D C AV ++M CW + A R + L++++ L
Sbjct: 404 KMDA----------------PDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL 440
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 97.1 bits (240), Expect = 4e-20
Identities = 76/293 (25%), Positives = 136/293 (46%), Gaps = 48/293 (16%)
Query: 232 KQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 291
K++++++ +GKG +G+V +G +RG KVAVK A F T L RH N++
Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL-RHSNLVQL 251
Query: 292 IAADIKGTGSWTQLYLITDYHENGSLYDFLKC---ATLDTRALLKLAYSAACGLCHLHTE 348
+ ++ G LY++T+Y GSL D+L+ + L LLK + +C
Sbjct: 252 LGVIVEEKGG---LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLD----VCEAMEY 304
Query: 349 IYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYM 408
+ G HRDL ++N+L+ ++ ++D GL + +S + +P+ ++
Sbjct: 305 LEGNN----FVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPV-------KWT 353
Query: 409 APEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYE 468
APE L E +D++SFG+++WE+ + G V ++P ++VP
Sbjct: 354 APEALREKKFSTK------SDVWSFGILLWEI----YSFGRVPYPRIPLKDVVPRVEKGY 403
Query: 469 DMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTL 521
M D C AV ++M CW + A R + L++++ L
Sbjct: 404 KMDA----------------PDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQL 440
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 94.7 bits (234), Expect = 2e-19
Identities = 86/290 (29%), Positives = 132/290 (45%), Gaps = 58/290 (20%)
Query: 234 IQMVRQVGKGRYGEVWMGKWRGE-KVAVKVFFTTEEASWFRETEIYQTVLMR---HENIL 289
+++V ++G G++GEVWMG + G KVAVK + ++ S + + + LM+ H+ ++
Sbjct: 245 LKLVERLGAGQFGEVWMGYYNGHTKVAVK---SLKQGSMSPDAFLAEANLMKQLQHQRLV 301
Query: 290 GFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCAT---LDTRALLKLAYSAACGLCHLH 346
A + +Y+IT+Y ENGSL DFLK + L LL +A A G+ +
Sbjct: 302 RLYAVVTQ-----EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIE 356
Query: 347 TEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTK- 405
Y HRDL++ NIL+ SC IAD GLA D R G K
Sbjct: 357 ERNY--------IHRDLRAANILVSDTLSCKIADFGLARLIE------DNEYTAREGAKF 402
Query: 406 --RYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPS 463
++ APE + N+ I +D++SFG+++ E IV ++PY M
Sbjct: 403 PIKWTAPEAI------NYGTFTIKSDVWSFGILLTE---------IVTHGRIPYPGMTNP 447
Query: 464 DPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLT 513
+ R + +RP D C + +LM CW P R T
Sbjct: 448 EVIQNLERG---YRMVRP--------DNCPEELYQLMRLCWKERPEDRPT 486
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 94.7 bits (234), Expect = 2e-19
Identities = 86/290 (29%), Positives = 132/290 (45%), Gaps = 58/290 (20%)
Query: 234 IQMVRQVGKGRYGEVWMGKWRGE-KVAVKVFFTTEEASWFRETEIYQTVLMR---HENIL 289
+++V ++G G++GEVWMG + G KVAVK + ++ S + + + LM+ H+ ++
Sbjct: 245 LKLVERLGAGQFGEVWMGYYNGHTKVAVK---SLKQGSMSPDAFLAEANLMKQLQHQRLV 301
Query: 290 GFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCAT---LDTRALLKLAYSAACGLCHLH 346
A + +Y+IT+Y ENGSL DFLK + L LL +A A G+ +
Sbjct: 302 RLYAVVTQ-----EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIE 356
Query: 347 TEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTK- 405
Y HRDL++ NIL+ SC IAD GLA D R G K
Sbjct: 357 ERNY--------IHRDLRAANILVSDTLSCKIADFGLARLIE------DNEYTAREGAKF 402
Query: 406 --RYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPS 463
++ APE + N+ I +D++SFG+++ E IV ++PY M
Sbjct: 403 PIKWTAPEAI------NYGTFTIKSDVWSFGILLTE---------IVTHGRIPYPGMTNP 447
Query: 464 DPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLT 513
+ R + +RP D C + +LM CW P R T
Sbjct: 448 EVIQNLERG---YRMVRP--------DNCPEELYQLMRLCWKERPEDRPT 486
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 92.4 bits (228), Expect = 9e-19
Identities = 82/307 (26%), Positives = 144/307 (46%), Gaps = 55/307 (17%)
Query: 232 KQIQMVRQVGKGRYGEVWMGKWRGE-KVAVKVFFTTEEA-SWFRETEIYQTVLMRHENIL 289
++ + R++G G +GEV+ G W+ +VA+KV ++EI +RH++IL
Sbjct: 189 EEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHIL 248
Query: 290 GFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCA---TLDTRALLKLAYSAACGLCHLH 346
A G +Y+IT+ GSL + L+ + L LL +A+ A G+C+L
Sbjct: 249 ALYAVVSVGD----PVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 304
Query: 347 TEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSD---TNEVDVPLNTRVG 403
++ Y HRDL ++NIL+ +N C + D GLA D +++ ++P
Sbjct: 305 SQNY--------IHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPY----- 351
Query: 404 TKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPS 463
++ AP E+L++ H+ +D++SFG+++ EM R Q+PY P
Sbjct: 352 --KWTAP----EALSRGHYS--TKSDVWSFGILLHEMFSR---------GQVPY----PG 390
Query: 464 DPSYEDMREVVCVKRLR-PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLA 522
++E V R+ P+ EC +V KLM CW +P R +++ L+
Sbjct: 391 MSNHEAFLRVDAGYRMPCPL--------ECPPSVHKLMLTCWCRDPEQRPCFKALRERLS 442
Query: 523 KMVESQD 529
++
Sbjct: 443 SFTSYEN 449
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 89.7 bits (221), Expect = 6e-18
Identities = 81/291 (27%), Positives = 133/291 (45%), Gaps = 56/291 (19%)
Query: 232 KQIQMVRQVGKGRYGEVWMGKWRGE-KVAVKVF--FTTEEASWFRETEIYQTVLMRHENI 288
+ +Q+++++G G++GEVWMG W G KVA+K T S+ E +I + ++H+ +
Sbjct: 269 ESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKK--LKHDKL 326
Query: 289 LGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCA---TLDTRALLKLAYSAACGLCHL 345
+ A S +Y++T+Y GSL DFLK L L+ +A A G+ ++
Sbjct: 327 VQLYA-----VVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYI 381
Query: 346 HTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTK 405
Y HRDL+S NIL+ C IAD GLA D R G K
Sbjct: 382 ERMNY--------IHRDLRSANILVGNGLICKIADFGLARLIE------DNEYTARQGAK 427
Query: 406 ---RYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVP 462
++ APE + + I +D++SFG+++ E +V + ++PY P
Sbjct: 428 FPIKWTAPEA------ALYGRFTIKSDVWSFGILLTE---------LVTKGRVPY----P 468
Query: 463 SDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLT 513
+ E + +V R+ +C ++ +LM CW +P R T
Sbjct: 469 GMNNREVLEQVERGYRMP-------CPQDCPISLHELMIHCWKKDPEERPT 512
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 87.4 bits (215), Expect = 3e-17
Identities = 80/296 (27%), Positives = 135/296 (45%), Gaps = 53/296 (17%)
Query: 234 IQMVRQVGKGRYGEVWMGKW--RGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 291
+Q G G +G V+ KW + ++VAVK E +E EI ++ H NI+ F
Sbjct: 16 LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQF 68
Query: 292 IAADIKGTGSWTQLYLITDYHENGSLYDFL---KCATLDTRALLKLAYSAACGLCHLHTE 348
++ ++T+Y GSLYD++ + +D ++ A A G+ +LH E
Sbjct: 69 YGVILEPPNYG----IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME 124
Query: 349 IYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYM 408
+ HRDLKS+N++I +G I D G A +F++ T + + VGT +M
Sbjct: 125 -----APVKVIHRDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSL-----VGTFPWM 173
Query: 409 APEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYE 468
APEV+ +SL + D YS+G+++WEM R + +E Q+ +
Sbjct: 174 APEVI-QSLPVSE-----TCDTYSYGVVLWEMLTREVPFKGLEGLQVAW----------- 216
Query: 469 DMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524
+V K R + + C R+ +L+ +CW + R + +I L M
Sbjct: 217 ----LVVEKNERLTIPS-----SCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 87.4 bits (215), Expect = 3e-17
Identities = 80/296 (27%), Positives = 135/296 (45%), Gaps = 53/296 (17%)
Query: 234 IQMVRQVGKGRYGEVWMGKW--RGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGF 291
+Q G G +G V+ KW + ++VAVK E +E EI ++ H NI+ F
Sbjct: 16 LQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIE-----KEAEILS--VLSHRNIIQF 68
Query: 292 IAADIKGTGSWTQLYLITDYHENGSLYDFL---KCATLDTRALLKLAYSAACGLCHLHTE 348
++ ++T+Y GSLYD++ + +D ++ A A G+ +LH E
Sbjct: 69 YGVILEPPNYG----IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHME 124
Query: 349 IYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYM 408
+ HRDLKS+N++I +G I D G A +F++ T + + VGT +M
Sbjct: 125 -----APVKVIHRDLKSRNVVIAADGVLKICDFG-ASRFHNHTTHMSL-----VGTFPWM 173
Query: 409 APEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYE 468
APEV+ +SL + D YS+G+++WEM R + +E Q+ +
Sbjct: 174 APEVI-QSLPVSE-----TCDTYSYGVVLWEMLTREVPFKGLEGLQVAW----------- 216
Query: 469 DMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524
+V K R + + C R+ +L+ +CW + R + +I L M
Sbjct: 217 ----LVVEKNERLTIPS-----SCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263
>gi|33188459 B-Raf [Homo sapiens]
Length = 766
Score = 87.0 bits (214), Expect = 4e-17
Identities = 85/278 (30%), Positives = 135/278 (48%), Gaps = 44/278 (15%)
Query: 233 QIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTT----EEASWFRETEIYQTVLMRHENI 288
QI + +++G G +G V+ GKW G+ VAVK+ T ++ F+ E+ RH NI
Sbjct: 456 QITVGQRIGSGSFGTVYKGKWHGD-VAVKMLNVTAPTPQQLQAFKN-EVGVLRKTRHVNI 513
Query: 289 LGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKC--ATLDTRALLKLAYSAACGLCHLH 346
L F+ K QL ++T + E SLY L + L+ +A A G+ +LH
Sbjct: 514 LLFMGYSTK-----PQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLH 568
Query: 347 TEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLA-VKFNSDTNEVDVPLNTRVGTK 405
+ +I HRDLKS NI + ++ + I D GLA VK + L+ G+
Sbjct: 569 AK--------SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLS---GSI 617
Query: 406 RYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDP 465
+MAPEV+ +KN + +D+Y+FG++++E+ +TG QLPY N+ D
Sbjct: 618 LWMAPEVI-RMQDKNPYS--FQSDVYAFGIVLYEL----MTG------QLPYSNINNRDQ 664
Query: 466 SYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSEC 503
+ L + SN C +A+ +LM+EC
Sbjct: 665 IIFMVGRGYLSPDLSKVRSN------CPKAMKRLMAEC 696
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,287,013
Number of Sequences: 37866
Number of extensions: 908412
Number of successful extensions: 3348
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 359
Number of HSP's successfully gapped in prelim test: 352
Number of HSP's that attempted gapping in prelim test: 2008
Number of HSP's gapped (non-prelim): 820
length of query: 532
length of database: 18,247,518
effective HSP length: 107
effective length of query: 425
effective length of database: 14,195,856
effective search space: 6033238800
effective search space used: 6033238800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.