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Search of human proteins with 41327779
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|41327779 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 [Homo
sapiens]
(600 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|41327779 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 [Homo sapi... 1192 0.0
gi|13514831 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 [Homo sapi... 304 1e-82
gi|38327634 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 [Homo sapi... 285 8e-77
gi|17505907 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 isoform 1 ... 216 5e-56
gi|20149629 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 1 ... 201 1e-51
gi|21071032 DEAD-box protein abstrakt [Homo sapiens] 192 6e-49
gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo sapi... 181 2e-45
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 179 8e-45
gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo sapi... 178 1e-44
gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo sap... 177 2e-44
gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo sap... 176 7e-44
gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens] 174 2e-43
gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens] 174 2e-43
gi|41327776 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 2 ... 173 4e-43
gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens] 173 5e-43
gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens] 173 5e-43
gi|51094101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 2 ... 168 1e-41
gi|164419743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 1... 168 1e-41
gi|7661920 eukaryotic translation initiation factor 4A, isoform ... 167 2e-41
gi|188035877 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 [Homo sap... 167 3e-41
gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3 ... 163 4e-40
gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1 [... 163 4e-40
gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2 ... 163 4e-40
gi|4503529 eukaryotic translation initiation factor 4A isoform 1... 161 2e-39
gi|83700235 eukaryotic translation initiation factor 4A2 [Homo s... 160 2e-39
gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens] 159 5e-39
gi|87196351 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 [Homo... 156 4e-38
gi|13129006 nucleolar protein GU2 [Homo sapiens] 154 2e-37
gi|50659095 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Homo sapi... 154 2e-37
gi|169881239 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked ... 152 1e-36
>gi|41327779 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 [Homo
sapiens]
Length = 600
Score = 1192 bits (3083), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 1 MEHVTEGSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKT 60
MEHVTEGSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKT
Sbjct: 1 MEHVTEGSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKT 60
Query: 61 LAFVIPILEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGG 120
LAFVIPILEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGG
Sbjct: 61 LAFVIPILEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGG 120
Query: 121 RNPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMG 180
RNPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMG
Sbjct: 121 RNPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMG 180
Query: 181 FEASINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPS 240
FEASINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPS
Sbjct: 181 FEASINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPS 240
Query: 241 RLENYYMVCKADEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIH 300
RLENYYMVCKADEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIH
Sbjct: 241 RLENYYMVCKADEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIH 300
Query: 301 GKMKYKRNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTA 360
GKMKYKRNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTA
Sbjct: 301 GKMKYKRNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTA 360
Query: 361 RIGHGGSALVFLLPMEESYINFLAINQKCPLQEMKPQRNTADLLPKLKSMALADRAVFEK 420
RIGHGGSALVFLLPMEESYINFLAINQKCPLQEMKPQRNTADLLPKLKSMALADRAVFEK
Sbjct: 361 RIGHGGSALVFLLPMEESYINFLAINQKCPLQEMKPQRNTADLLPKLKSMALADRAVFEK 420
Query: 421 GMKAFVSYVQAYAKHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVN 480
GMKAFVSYVQAYAKHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVN
Sbjct: 421 GMKAFVSYVQAYAKHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVN 480
Query: 481 TDTIPFKDKIREKQRQKLLEQQRREKTENEGRRKFIKNKAWSKQKAKKEKKKKMNEKRKR 540
TDTIPFKDKIREKQRQKLLEQQRREKTENEGRRKFIKNKAWSKQKAKKEKKKKMNEKRKR
Sbjct: 481 TDTIPFKDKIREKQRQKLLEQQRREKTENEGRRKFIKNKAWSKQKAKKEKKKKMNEKRKR 540
Query: 541 EEGSDIEDEDMEELLNDTRLLKKLKKGKITEEEFEKGLLTTGKRTIKTVDLGISDLEDDC 600
EEGSDIEDEDMEELLNDTRLLKKLKKGKITEEEFEKGLLTTGKRTIKTVDLGISDLEDDC
Sbjct: 541 EEGSDIEDEDMEELLNDTRLLKKLKKGKITEEEFEKGLLTTGKRTIKTVDLGISDLEDDC 600
>gi|13514831 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 [Homo
sapiens]
Length = 875
Score = 304 bits (779), Expect = 1e-82
Identities = 202/551 (36%), Positives = 311/551 (56%), Gaps = 39/551 (7%)
Query: 15 PLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRR 74
PL + L L+E + +T +Q TI L ++ KDV A TGSGKTLAF++P+LE L R
Sbjct: 75 PLSKKTLKGLQEAQYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRL 134
Query: 75 EEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQG 134
+ +G +II+PTRELA Q EVL K+ +FS L IGG++ + ER
Sbjct: 135 QWT-STDGLGVLIISPTRELAYQTFEVLRKVGKNH-DFSAGLIIGGKDLKHEAERINNI- 191
Query: 135 GNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPK 194
NI+V TPGRL + E + + L +LVLDEADR+LDMGF ++N ++E LPK
Sbjct: 192 -NILVCTPGRL---LQHMDETVSFHAT--DLQMLVLDEADRILDMGFADTMNAVIENLPK 245
Query: 195 QRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEK 254
+R+T LFSATQT+ V++L R L+NP V V EK + TP+ LE Y+VC+ +K
Sbjct: 246 KRQTLLFSATQTKSVKDLARLSLKNPEYVWVHEK-----AKYSTPATLEQNYIVCELQQK 300
Query: 255 FNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKY-KRNKIFME 313
+ L FLR+H ++K +VFFS+C V+Y + L GV I+ +HG+ + +R +++ E
Sbjct: 301 ISVLYSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGVSILALHGRQQQMRRMEVYNE 360
Query: 314 FRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLL 373
F + ++ +L TD+ ARG+D P VNWVLQ+D P +A+ ++HR GRTAR G AL+ LL
Sbjct: 361 FVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTARYKEDGEALLILL 420
Query: 374 PMEESYINFLAINQKCPLQEMK--PQRNTADLLPKLKSMALADRAVFEKGMKAFVSYVQA 431
P E++ + L + +K P++E+K P++ D+ KL+S+ D+ + E+ + FVSYV++
Sbjct: 421 PSEKAMVQQL-LQKKVPVKEIKINPEK-LIDVQKKLESILAQDQDLKERAQRCFVSYVRS 478
Query: 432 YAKHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVNTDTIPFKDKIR 491
+ +F + L A L P++ L+ Q P K+ +R
Sbjct: 479 VYLMKDKEVFDVSKLPIPEYALSLGLAVAPRVRFLQKMQ------------KQPTKELVR 526
Query: 492 EKQRQKLLEQQRREKTENEGR--RKFIKNKAWSKQKAKK-----EKKKKMNEKRKREEGS 544
Q K++E + T +E R + K QK K E ++ + + +E
Sbjct: 527 -SQADKVIEPRAPSLTNDEVEEFRAYFNEKMSILQKGGKRLEGTEHRQDNDTGNEEQEEE 585
Query: 545 DIEDEDMEELL 555
+ ++E+MEE L
Sbjct: 586 EDDEEEMEEKL 596
Score = 37.4 bits (85), Expect = 0.040
Identities = 35/138 (25%), Positives = 66/138 (47%), Gaps = 30/138 (21%)
Query: 487 KDKIREKQRQKLLEQQRREKT--ENEGRRKFIKNKAWSKQKAKKEKKKKMN--------- 535
+DK +++ +K ++ + REK E E RR+ K +A KAK E++ ++
Sbjct: 732 EDKFDKEEYRKKIKAKHREKRLKEREARREANKRQA----KAKDEEEAFLDWSDDDDDDD 787
Query: 536 ---------EKRKREEGSDIEDEDMEELLNDTRLLKKLKKGKITEEEFEKGLLTTGKR-- 584
+ K D + EDME ++DT+ + +KK +E E + G + ++
Sbjct: 788 DGFDPSTLPDPDKYRSSEDSDSEDMENKISDTKKKQGMKKRSNSEVE-DVGPTSHNRKKA 846
Query: 585 ---TIKTVDLGISDLEDD 599
T++ +D G+S ED+
Sbjct: 847 RWDTLEPLDTGLSLAEDE 864
>gi|38327634 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 [Homo
sapiens]
Length = 670
Score = 285 bits (729), Expect = 8e-77
Identities = 186/536 (34%), Positives = 295/536 (55%), Gaps = 50/536 (9%)
Query: 8 SWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPI 67
S+ SL ++ L A++E+GF MT +Q +I + +D+ A A TGSGKTLAF+IP
Sbjct: 178 SFASLCNLVNENTLKAIKEMGFTNMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPA 237
Query: 68 LEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDV 127
+E++++ + ++ G +I++PTRELA+Q VL H ++ +GG N +
Sbjct: 238 VELIVKLRF-MPRNGTGVLILSPTRELAMQTFGVLKELMTHHVHTYGLI-MGGSNRSAEA 295
Query: 128 ERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINT 187
++ G NIIVATPGRL D + + ++L LV+DEADR+LD+GFE +
Sbjct: 296 QKLGN-GINIIVATPGRLLDHMQNTPGFM-----YKNLQCLVIDEADRILDVGFEEELKQ 349
Query: 188 ILEFLPKQRRTGLFSATQTQEVENLVRAGLRN-PVRVSVKEKGVAASSAQKTPSRLENYY 246
I++ LP +R+T LFSATQT++VE+L R L+ P+ V GV A T LE Y
Sbjct: 350 IIKLLPTRRQTMLFSATQTRKVEDLARISLKKEPLYV-----GVDDDKANATVDGLEQGY 404
Query: 247 MVCKADEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKY- 305
+VC ++++F L FL+ ++++K +VFFS+C V+Y+ + L + + ++ IHGK K
Sbjct: 405 VVCPSEKRFLLLFTFLKKNRKKKLMVFFSSCMSVKYHYELLNYI--DLPVLAIHGKQKQN 462
Query: 306 KRNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHG 365
KR F +F SG L+CTDV ARG+DIPEV+W++QYDPP + ++HR GRTAR +G
Sbjct: 463 KRTTTFFQFCNADSGTLLCTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGLNG 522
Query: 366 -GSALVFLLPMEESYINFLAINQKCPLQEMK-PQRNTADLLPKLKSMALADRAVFEKGMK 423
G AL+ L P E ++ +L K PL E +D+ +L+ + + + + +
Sbjct: 523 RGHALLILRPEELGFLRYLK-QSKVPLSEFDFSWSKISDIQSQLEKLIEKNYFLHKSAQE 581
Query: 424 AFVSYVQAYAKHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVNTDT 483
A+ SY++AY H IF + +L+ +A F G + P FV ++VN++
Sbjct: 582 AYKSYIRAYDSHSLKQIFNVNNLNLPQVALSF------------GFKVPPFVDLNVNSN- 628
Query: 484 IPFKDKIREKQRQKLLEQQRREKTENEGRRKFIKNKAWSKQKAKKEKKKKMNEKRK 539
+ +++K G + K K K K K KK ++ R+
Sbjct: 629 -----------------EGKQKKRGGGGGFGYQKTKKVEKSKIFKHISKKSSDSRQ 667
>gi|17505907 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 isoform 1
[Homo sapiens]
Length = 851
Score = 216 bits (550), Expect = 5e-56
Identities = 163/525 (31%), Positives = 258/525 (49%), Gaps = 85/525 (16%)
Query: 16 LHPQVLGALRE-LGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRR 74
LHP ++ + L MT VQ +IP+ + +D + TGSGKTLA+ IP+++ L
Sbjct: 237 LHPHLISTINTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCIPVVQSLQAM 296
Query: 75 EEKLKKSQVG-AIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQ 133
E K+++S A+++ PTRELA+Q + + K F + +GG + R ++
Sbjct: 297 ESKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRK- 355
Query: 134 GGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLP 193
G NI+++TPGRL D + + + + L LV DEADR+LD+GFE I IL +
Sbjct: 356 GINILISTPGRLVDHIK-STKNIHFSR----LRWLVFDEADRILDLGFEKDITVILNAVN 410
Query: 194 ---KQRRTGLFSATQTQEVENLVRAGLRNPVRVSV----------KEKGVAASSAQKT-- 238
++R+ L SAT T+ V L L +PV +SV K+K V
Sbjct: 411 AECQKRQNVLLSATLTEGVTRLADISLHDPVSISVLDKSHDQLNPKDKAVQEVCPPPAGD 470
Query: 239 -------PSRLENYYMVCKADEKFNQLVHFL----RNHKQEKHLVFFSTCACVEY-YGKA 286
P L+ + V + + L F+ + + +K +VFFS+C VE+ Y
Sbjct: 471 KLDSFAIPESLKQHVTVVPSKLRLVCLAAFILQKCKFEEDQKMVVFFSSCELVEFHYSLF 530
Query: 287 LEVLVKG---------------VKIMCIHGKMKYK-RNKIFMEFRKLQSGILVCTDVMAR 330
L+ L+ +K + +HG M+ + R +F EF + G+L+CTDV AR
Sbjct: 531 LQTLLSSSGAPASGQLPSASMRLKFLRLHGGMEQEERTAVFQEFSHSRRGVLLCTDVAAR 590
Query: 331 GIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLPMEESYINFLAINQKCP 390
G+D+P+V W++QY+ PS+ + ++HR GRTARIG GS+L+ L P E Y+N LA + K
Sbjct: 591 GLDLPQVTWIVQYNAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLA-SHKIN 649
Query: 391 LQEMK--------------------PQRNTADLLPKLKSMALADRAVFEK---------- 420
+ E+K Q++ A +++ A + VFE
Sbjct: 650 VSEIKMEDILCVLTRDDCFKGKRWGAQKSHAVGPQEIRERATVLQTVFEDYVHSSERRVS 709
Query: 421 -GMKAFVSYVQAYAKH--ECNLIFRLKDLDFASLARGFALLRMPK 462
KA S++QAYA + E IF ++ L +A+ F L P+
Sbjct: 710 WAKKALQSFIQAYATYPRELKHIFHVRSLHLGHVAKSFGLRDAPR 754
>gi|20149629 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 1
[Homo sapiens]
Length = 455
Score = 201 bits (512), Expect = 1e-51
Identities = 130/351 (37%), Positives = 197/351 (56%), Gaps = 22/351 (6%)
Query: 23 ALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLKKSQ 82
A +LG+ T +Q IPL ++ +D+ A TGSGKT AF +PIL LL ++L
Sbjct: 38 ACDQLGWTKPTKIQIEAIPLALQGRDIIGLAETGSGKTGAFALPILNALLETPQRLF--- 94
Query: 83 VGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNIIVATP 142
A+++TPTRELA QI E S ++ G + + + K+ +II+ATP
Sbjct: 95 --ALVLTPTRELAFQISEQFEALGSSIGVQSAVIVGGIDSMSQSLALAKKP--HIIIATP 150
Query: 143 GRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRTGLFS 202
GRL D +G +L R+L LV+DEADR+L+M FE ++ IL+ +P+ R+T LFS
Sbjct: 151 GRLIDHLEN-TKGFNL----RALKYLVMDEADRILNMDFETEVDKILKVIPRDRKTFLFS 205
Query: 203 ATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLVHFL 262
AT T++V+ L RA L+NPV+ +V SS +T +L+ YY+ + K LV+ L
Sbjct: 206 ATMTKKVQKLQRAALKNPVKCAV-------SSKYQTVEKLQQYYIFIPSKFKDTYLVYIL 258
Query: 263 RNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKM-KYKRNKIFMEFRKLQSGI 321
++F STC + L L G + +HG+M + KR +F+ I
Sbjct: 259 NELAGNSFMIFCSTCNNTQRTALLLRNL--GFTAIPLHGQMSQSKRLGSLNKFKAKARSI 316
Query: 322 LVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFL 372
L+ TDV +RG+DIP V+ V+ +D P+++ ++HR GRTAR G G A+ F+
Sbjct: 317 LLATDVASRGLDIPHVDVVVNFDIPTHSKDYIHRVGRTARAGRSGKAITFV 367
>gi|21071032 DEAD-box protein abstrakt [Homo sapiens]
Length = 622
Score = 192 bits (489), Expect = 6e-49
Identities = 128/362 (35%), Positives = 196/362 (54%), Gaps = 26/362 (7%)
Query: 20 VLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKL- 78
+L L++ G + TP+Q IP + +D+ A TGSGKTL F +P++ L +E++L
Sbjct: 192 ILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLP 251
Query: 79 --KKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQ-----ILWIGGRNPGEDVERFK 131
K+ +II P+RELA Q +L ++ + E S L IGG + E +E +
Sbjct: 252 FSKREGPYGLIICPSRELARQTHGILEYYCRLLQEDSSPLLRCALCIGGMSVKEQMETIR 311
Query: 132 QQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEF 191
G +++VATPGRL D+ ++K LD+ L LDEADR++DMGFE I TI +
Sbjct: 312 H-GVHMMVATPGRLMDLLQKKMVSLDICR------YLALDEADRMIDMGFEGDIRTIFSY 364
Query: 192 LPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKA 251
QR+T LFSAT ++++N ++ L PV ++V G A+ + E Y+ K
Sbjct: 365 FKGQRQTLLFSATMPKKIQNFAKSALVKPVTINVGRAGAASLDVIQ-----EVEYV--KE 417
Query: 252 DEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIH-GKMKYKRNKI 310
+ K L+ L+ L+F A V+ + L L+KGV+ + IH GK + +R K
Sbjct: 418 EAKMVYLLECLQK-TPPPVLIFAEKKADVDAIHEYL--LLKGVEAVAIHGGKDQEERTKA 474
Query: 311 FMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALV 370
FR+ + +LV TDV ++G+D P + V+ YD P +VHR GRT R G+ G A
Sbjct: 475 IEAFREGKKDVLVATDVASKGLDFPAIQHVINYDMPEEIENYVHRIGRTGRSGNTGIATT 534
Query: 371 FL 372
F+
Sbjct: 535 FI 536
>gi|164664518 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 [Homo
sapiens]
Length = 483
Score = 181 bits (458), Expect = 2e-45
Identities = 113/355 (31%), Positives = 188/355 (52%), Gaps = 23/355 (6%)
Query: 16 LHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRRE 75
L ++L + E+G+ +P+Q +IP+ + +D+ A A G+GK+ A++IP+LE L
Sbjct: 103 LKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERL---- 158
Query: 76 EKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGG 135
LKK + A++I PTRELA+Q+ ++ +KH + GG N +D+ R
Sbjct: 159 -DLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTV- 216
Query: 136 NIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQ 195
++++ATPGR+ D+ ++ +D + ++VLDEAD+LL F + I+ LPK
Sbjct: 217 HVVIATPGRILDLIKKGVAKVD------HVQMIVLDEADKLLSQDFVQIMEDIILTLPKN 270
Query: 196 RRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKF 255
R+ L+SAT V+ + + L+ P +++ E + T + YY +K
Sbjct: 271 RQILLYSATFPLSVQKFMNSHLQKPYEINLME--------ELTLKGVTQYYAYVTERQKV 322
Query: 256 NQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKYK-RNKIFMEF 314
+ L + + ++F ++ VE K + L G IH KM+ + RN++F +F
Sbjct: 323 HCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQL--GYSCFYIHAKMRQEHRNRVFHDF 380
Query: 315 RKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSAL 369
R LVCTD+ RGIDI VN V+ +D P A ++HR GR+ R GH G A+
Sbjct: 381 RNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAI 435
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 179 bits (453), Expect = 8e-45
Identities = 120/373 (32%), Positives = 191/373 (51%), Gaps = 16/373 (4%)
Query: 8 SWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPI 67
SW + + ++L +L++ G+ TP+Q+ IP M +D+ A TGSGKT+AF++P+
Sbjct: 373 SWVQCGISM--KILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFLLPM 430
Query: 68 LEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDV 127
++ + + A+I+TPTRELA+QI + F+K + GG E +
Sbjct: 431 FRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTL-GLRVVCVYGGTGISEQI 489
Query: 128 ERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINT 187
K +G IIV TPGR+ DM A + +R + +VLDEADR+ DMGFE +
Sbjct: 490 AELK-RGAEIIVCTPGRMIDML---AANSGRVTNLRRVTYVVLDEADRMFDMGFEPQVMR 545
Query: 188 ILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYM 247
I++ + R+T +FSAT + +E L R L P+ V V + V S +E +
Sbjct: 546 IVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSD-------VEQQVI 598
Query: 248 VCKADEKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKM-KYK 306
V + ++KF +L+ L H QE V G +++ M +HG + +Y
Sbjct: 599 VIEEEKKFLKLLELL-GHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYD 657
Query: 307 RNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGG 366
R+ I +F+ +LV T V ARG+D+ + V+ Y P++ +VHR GRT R G+ G
Sbjct: 658 RDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKG 717
Query: 367 SALVFLLPMEESY 379
A F+ + Y
Sbjct: 718 YAYTFITEDQARY 730
Score = 34.3 bits (77), Expect = 0.34
Identities = 33/126 (26%), Positives = 59/126 (46%), Gaps = 19/126 (15%)
Query: 487 KDKIREKQRQKLLEQQRR----------EKTENEGRRKFIKNKAWSKQKAKKEKKKKMNE 536
+ + R+++R + + RR +KTEN R K + S ++ KK+K K +E
Sbjct: 84 RSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSKEKTDGGESSKEKKKDKDDKEDE 143
Query: 537 KRKREEGSDIEDEDMEELLNDTRLLKKLKKGKITEEEFEKGLLTTG--KRTIKTVDLGIS 594
K K + + + +EE + +K + K EE+ +K + G K+ I+ + G
Sbjct: 144 KEK--DAGNFDQNKLEEEMRK----RKERVEKWREEQRKKAMENIGELKKEIEEMKQGKK 197
Query: 595 -DLEDD 599
LEDD
Sbjct: 198 WSLEDD 203
>gi|41327771 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 [Homo
sapiens]
Length = 820
Score = 178 bits (451), Expect = 1e-44
Identities = 133/396 (33%), Positives = 195/396 (49%), Gaps = 50/396 (12%)
Query: 8 SWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPI 67
SW+ +P P +L + + G+ TP+Q IP+ ++N+D+ A TGSGKT AF+IP+
Sbjct: 392 SWKDSSLP--PHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPL 449
Query: 68 LEIL--LRREEKLKKSQVG--AIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNP 123
L + L + +++++S G AII+ PTRELA QI+E F K + IGG +
Sbjct: 450 LVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLG-IRTVAVIGGISR 508
Query: 124 GEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEA 183
+ R + G I++ATPGRL D+ + L L+ C +VLDEADR++DMGFE
Sbjct: 509 EDQGFRLRM-GCEIVIATPGRLIDVLENRY--LVLSRCT----YVVLDEADRMIDMGFEP 561
Query: 184 SINTILEFLP--------------------------KQRRTGLFSATQTQEVENLVRAGL 217
+ ILE +P K R+T +F+AT VE L R+ L
Sbjct: 562 DVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYL 621
Query: 218 RNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLVHFLRNHKQEKHLVFFSTC 277
R P V + SA K R+E + EK +L+ L ++F +
Sbjct: 622 RRPAVVYI-------GSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQK 674
Query: 278 ACVEYYGKALEVLVKGVKIMCIHG-KMKYKRNKIFMEFRKLQSGILVCTDVMARGIDIPE 336
+ K+LE + G +HG K + +R + ILV TDV RGIDI +
Sbjct: 675 KGCDVLAKSLEKM--GYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQD 732
Query: 337 VNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFL 372
V+ V+ YD N ++HR GRT R G G A+ FL
Sbjct: 733 VSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFL 768
>gi|224593278 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 [Homo
sapiens]
Length = 796
Score = 177 bits (449), Expect = 2e-44
Identities = 152/579 (26%), Positives = 271/579 (46%), Gaps = 50/579 (8%)
Query: 20 VLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLK 79
+L A+ +GF TP+Q A IP+ + KD+ A A TG+GKT AF +P+LE L+ + +
Sbjct: 229 LLKAITAMGFKQPTPIQKACIPVGLLGKDICACAATGTGKTAAFALPVLERLIYKPRQAP 288
Query: 80 KSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNIIV 139
++V +++ PTREL IQ+ V + F + L +GG + + E + +I++
Sbjct: 289 VTRV--LVLVPTRELGIQVHSVTRQLAQ-FCNITTCLAVGGLDV-KSQEAALRAAPDILI 344
Query: 140 ATPGRLEDMFRRKAEGLDLASC----VRSLDVLVLDEADRLLDMGFEASINTILEFLPKQ 195
ATPGRL D L +C + S++VL+LDEADR+LD FE + I+
Sbjct: 345 ATPGRLID---------HLHNCPSFHLSSIEVLILDEADRMLDEYFEEQMKEIIRMCSHH 395
Query: 196 RRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKF 255
R+T LFSAT T EV++L L+NPVR+ V S+ P + + + E
Sbjct: 396 RQTMLFSATMTDEVKDLASVSLKNPVRIFVN------SNTDVAPFLRQEFIRIRPNREGD 449
Query: 256 NQ-LVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKM-KYKRNKIFME 313
+ +V L H++ F T + + + + + G+++ +HG + + +R +
Sbjct: 450 REAIVAALLTRTFTDHVMLF-TQTKKQAHRMHILLGLMGLQVGELHGNLSQTQRLEALRR 508
Query: 314 FRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLL 373
F+ Q ILV TDV ARG+DI V V+ + P+ +VHR GRTAR G G ++ +
Sbjct: 509 FKDEQIDILVATDVAARGLDIEGVKTVINFTMPNTIKHYVHRVGRTARAGRAGRSVSLVG 568
Query: 374 PMEESYINFLAINQKCPLQ-EMKPQRNTADLLPKLKSMALADRAVFE-KGMKAFVSYVQA 431
E + + K P++ + PQ K++ M AV + + + + +A
Sbjct: 569 EDERKMLKEIVKAAKAPVKARILPQDVILKFRDKIEKMEKDVYAVLQLEAEEKEMQQSEA 628
Query: 432 YAKHECNLIFRLKDLDFASLARGFALLRMPKMPELRGKQFPDFVPVDVNTDTIPFKDKIR 491
L+ + K+ R + + + E K +F + + K +
Sbjct: 629 QINTAKRLLEKGKEAVVQEPERSWFQTKEERKKEKIAKALQEF--------DLALRGKKK 680
Query: 492 EKQRQKLLEQQRREKTENEGRRKFIKNKAWSKQKAKKEKKKKMNE------------KRK 539
K+ K +++ E + + +K + ++++ AK+ ++ K K++
Sbjct: 681 RKKFMKDAKKKGEMTAEERSQFEILKAQMFAERLAKRNRRAKRARAMPEEEPVRGPAKKQ 740
Query: 540 REEGSDIEDEDMEELLNDTRLLKKLKKGKITEEEFEKGL 578
++ + DE++ + LK+ + G EE + GL
Sbjct: 741 KQGKKSVFDEELTN--TSKKALKQYRAGPSFEERKQLGL 777
>gi|222352149 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 [Homo
sapiens]
Length = 648
Score = 176 bits (445), Expect = 7e-44
Identities = 113/359 (31%), Positives = 197/359 (54%), Gaps = 20/359 (5%)
Query: 17 HPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIP-ILEILLRRE 75
+P+V+ +++ GF TP+QS P+ ++ D+ A TG+GKTL +++P + ++L+
Sbjct: 250 YPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQPS 309
Query: 76 EKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGG 135
K ++++ G +++TPTRELA+Q++ ++ + + GG N E +E K+ G
Sbjct: 310 LKGQRNRPGMLVLTPTRELALQVEGECCKYS--YKGLRSVCVYGGGNRDEQIEELKK-GV 366
Query: 136 NIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQ 195
+II+ATPGRL D+ L +++ LVLDEAD++LDMGFE I IL +
Sbjct: 367 DIIIATPGRLNDLQMSNFVNL------KNITYLVLDEADKMLDMGFEPQIMKILLDVRPD 420
Query: 196 RRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKF 255
R+T + SAT V L ++ L+ P+ V V + A S+ K +V +EK+
Sbjct: 421 RQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDLVAVSSVK------QNIIVTTEEEKW 474
Query: 256 NQLVHFLRNHKQ-EKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKYK-RNKIFME 313
+ + FL++ +K +VF S A ++ ++++ + + +HG + + R K
Sbjct: 475 SHMQTFLQSMSSTDKVIVFVSRKAVADHLSS--DLILGNISVESLHGDREQRDREKALEN 532
Query: 314 FRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFL 372
F+ + IL+ TD+ +RG+D+ +V V +D P N +VHR GRT R G G ++ L
Sbjct: 533 FKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAGRTGVSITTL 591
>gi|148613856 DEAD box polypeptide 17 isoform 3 [Homo sapiens]
Length = 731
Score = 174 bits (441), Expect = 2e-43
Identities = 119/356 (33%), Positives = 187/356 (52%), Gaps = 14/356 (3%)
Query: 20 VLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLK 79
V+ L + F TP+Q PL + +D+ A TGSGKTLA+++P + + + +
Sbjct: 182 VMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLER 241
Query: 80 KSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNIIV 139
+++ PTRELA Q+ +V + K S ++ GG G + R ++G I +
Sbjct: 242 GDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIY-GGAPKGPQI-RDLERGVEICI 299
Query: 140 ATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRTG 199
ATPGRL D L R LVLDEADR+LDMGFE I I++ + R+T
Sbjct: 300 ATPGRLIDFLESGKTNL------RRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTL 353
Query: 200 LFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLV 259
++SAT +EV L LR+ +++V G SA ++ + M + D K QL+
Sbjct: 354 MWSATWPKEVRQLAEDFLRDYTQINV---GNLELSANHNILQIVDVCMESEKDHKLIQLM 410
Query: 260 HFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHG-KMKYKRNKIFMEFRKLQ 318
+ K+ K ++F T + + + G MCIHG K + +R+ + EFR +
Sbjct: 411 EEIMAEKENKTIIFVETKRRCDDLTRRMRR--DGWPAMCIHGDKSQPERDWVLNEFRSGK 468
Query: 319 SGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLP 374
+ IL+ TDV +RG+D+ +V +V+ YD P+++ +VHR GRTAR + G+A F P
Sbjct: 469 APILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTP 524
>gi|38201710 DEAD box polypeptide 17 isoform 1 [Homo sapiens]
Length = 729
Score = 174 bits (441), Expect = 2e-43
Identities = 119/356 (33%), Positives = 187/356 (52%), Gaps = 14/356 (3%)
Query: 20 VLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLK 79
V+ L + F TP+Q PL + +D+ A TGSGKTLA+++P + + + +
Sbjct: 182 VMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLER 241
Query: 80 KSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNIIV 139
+++ PTRELA Q+ +V + K S ++ GG G + R ++G I +
Sbjct: 242 GDGPICLVLAPTRELAQQVQQVADDYGKCSRLKSTCIY-GGAPKGPQI-RDLERGVEICI 299
Query: 140 ATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRTG 199
ATPGRL D L R LVLDEADR+LDMGFE I I++ + R+T
Sbjct: 300 ATPGRLIDFLESGKTNL------RRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTL 353
Query: 200 LFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLV 259
++SAT +EV L LR+ +++V G SA ++ + M + D K QL+
Sbjct: 354 MWSATWPKEVRQLAEDFLRDYTQINV---GNLELSANHNILQIVDVCMESEKDHKLIQLM 410
Query: 260 HFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHG-KMKYKRNKIFMEFRKLQ 318
+ K+ K ++F T + + + G MCIHG K + +R+ + EFR +
Sbjct: 411 EEIMAEKENKTIIFVETKRRCDDLTRRMRR--DGWPAMCIHGDKSQPERDWVLNEFRSGK 468
Query: 319 SGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLP 374
+ IL+ TDV +RG+D+ +V +V+ YD P+++ +VHR GRTAR + G+A F P
Sbjct: 469 APILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTFFTP 524
>gi|41327776 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 isoform 2
[Homo sapiens]
Length = 406
Score = 173 bits (439), Expect = 4e-43
Identities = 119/350 (34%), Positives = 177/350 (50%), Gaps = 69/350 (19%)
Query: 23 ALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLKKSQ 82
A +LG+ T +Q IPL ++ +D+ A TGSGKT AF +PIL LL ++L
Sbjct: 38 ACDQLGWTKPTKIQIEAIPLALQGRDIIGLAETGSGKTGAFALPILNALLETPQRLF--- 94
Query: 83 VGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNIIVATP 142
A+++TPTRELA QI E S ++ G + + + K+ +II+ATP
Sbjct: 95 --ALVLTPTRELAFQISEQFEALGSSIGVQSAVIVGGIDSMSQSLALAKKP--HIIIATP 150
Query: 143 GRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRTGLFS 202
GRL D +G +L R+L LV+DEADR+L+M FE ++ IL+ +P+ R+T LFS
Sbjct: 151 GRLIDHLEN-TKGFNL----RALKYLVMDEADRILNMDFETEVDKILKVIPRDRKTFLFS 205
Query: 203 ATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLVHFL 262
AT T++V+ L RA L+NPV+ +V SS +T +L+ YY+
Sbjct: 206 ATMTKKVQKLQRAALKNPVKCAV-------SSKYQTVEKLQQYYIF-------------- 244
Query: 263 RNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKYKRNKIFMEFRKLQSGIL 322
I K K KR +F+ IL
Sbjct: 245 ------------------------------------IPSKFKSKRLGSLNKFKAKARSIL 268
Query: 323 VCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFL 372
+ TDV +RG+DIP V+ V+ +D P+++ ++HR GRTAR G G A+ F+
Sbjct: 269 LATDVASRGLDIPHVDVVVNFDIPTHSKDYIHRVGRTARAGRSGKAITFV 318
>gi|45446747 DEAD box polypeptide 42 protein [Homo sapiens]
Length = 938
Score = 173 bits (438), Expect = 5e-43
Identities = 122/370 (32%), Positives = 182/370 (49%), Gaps = 18/370 (4%)
Query: 19 QVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKL 78
Q++ +R+ + TP+Q +P+ + +D+ A TGSGKT AF+ P+L ++ ++E
Sbjct: 263 QLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELE 322
Query: 79 KKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNII 138
A+I+ PTREL QI F K + + GG + E + Q+G I+
Sbjct: 323 PGDGPIAVIVCPTRELCQQIHAECKRFGKAY-NLRSVAVYGGGSMWEQAKAL-QEGAEIV 380
Query: 139 VATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRT 198
V TPGRL D ++KA L S LV DEADR+ DMGFE + +I + R+T
Sbjct: 381 VCTPGRLIDHVKKKATNLQRVS------YLVFDEADRMFDMGFEYQVRSIASHVRPDRQT 434
Query: 199 GLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQL 258
LFSAT +++E L R L +P+RV + G A + L + K+N L
Sbjct: 435 LLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHS------GPSKWNWL 488
Query: 259 VHFLRNHKQEKHLVFFSTC-ACVEYYGKALEVLVKGVKIMCIHGKM-KYKRNKIFMEFRK 316
L ++ F T A E L+ +G + +HG M + +RNK+ +F+K
Sbjct: 489 TRRLVEFTSSGSVLLFVTKKANAEELANNLKQ--EGHNLGLLHGDMDQSERNKVISDFKK 546
Query: 317 LQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLPME 376
+LV TDV ARG+DIP + V+ YD + HR GRT R G G A L P +
Sbjct: 547 KDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKD 606
Query: 377 ESYINFLAIN 386
++ L N
Sbjct: 607 SNFAGDLVRN 616
>gi|45446743 DEAD box polypeptide 42 protein [Homo sapiens]
Length = 938
Score = 173 bits (438), Expect = 5e-43
Identities = 122/370 (32%), Positives = 182/370 (49%), Gaps = 18/370 (4%)
Query: 19 QVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKL 78
Q++ +R+ + TP+Q +P+ + +D+ A TGSGKT AF+ P+L ++ ++E
Sbjct: 263 QLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELE 322
Query: 79 KKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNII 138
A+I+ PTREL QI F K + + GG + E + Q+G I+
Sbjct: 323 PGDGPIAVIVCPTRELCQQIHAECKRFGKAY-NLRSVAVYGGGSMWEQAKAL-QEGAEIV 380
Query: 139 VATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRT 198
V TPGRL D ++KA L S LV DEADR+ DMGFE + +I + R+T
Sbjct: 381 VCTPGRLIDHVKKKATNLQRVS------YLVFDEADRMFDMGFEYQVRSIASHVRPDRQT 434
Query: 199 GLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQL 258
LFSAT +++E L R L +P+RV + G A + L + K+N L
Sbjct: 435 LLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHS------GPSKWNWL 488
Query: 259 VHFLRNHKQEKHLVFFSTC-ACVEYYGKALEVLVKGVKIMCIHGKM-KYKRNKIFMEFRK 316
L ++ F T A E L+ +G + +HG M + +RNK+ +F+K
Sbjct: 489 TRRLVEFTSSGSVLLFVTKKANAEELANNLKQ--EGHNLGLLHGDMDQSERNKVISDFKK 546
Query: 317 LQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLPME 376
+LV TDV ARG+DIP + V+ YD + HR GRT R G G A L P +
Sbjct: 547 KDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKD 606
Query: 377 ESYINFLAIN 386
++ L N
Sbjct: 607 SNFAGDLVRN 616
>gi|51094101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 2
[Homo sapiens]
Length = 881
Score = 168 bits (426), Expect = 1e-41
Identities = 156/581 (26%), Positives = 266/581 (45%), Gaps = 68/581 (11%)
Query: 7 GSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIP 66
G ++S+ + +P G +++ G+ TP+Q TIP+ + KDV A A TGSGKT F++P
Sbjct: 96 GGFQSMGLS-YPVFKGIMKK-GYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLP 153
Query: 67 ILEILLRREEKLKKSQVGA--IIITPTRELAIQIDEVLSHFTKHFPEFSQI---LWIGGR 121
+ E L K +Q GA +I++PTRELA+Q + FTK +F+ + L +GG
Sbjct: 154 MFERL-----KTHSAQTGARALILSPTRELALQTLK----FTKELGKFTGLKTALILGGD 204
Query: 122 NPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGF 181
ED + +II+ATPGRL + ++++ ++S++ +V DEADRL +MGF
Sbjct: 205 RM-EDQFAALHENPDIIIATPGRLVHV------AVEMSLKLQSVEYVVFDEADRLFEMGF 257
Query: 182 EASINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSR 241
+ I+ LP +T LFSAT + + RAGL PV + + K +
Sbjct: 258 AEQLQEIIARLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVD-------TKLNEQ 310
Query: 242 LENYYMVCKADEKFNQLVHFLRN--HKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCI 299
L+ + + + D K L+H L N Q++ +VF +T EY L L+ ++ C
Sbjct: 311 LKTSFFLVREDTKAAVLLHLLHNVVRPQDQTVVFVATKHHAEY----LTELLTTQRVSCA 366
Query: 300 H--GKMKYKRNKIFM-EFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRC 356
H + KI + +F + L+ TD+ ARG+DIP ++ V+ Y P+ F+HR
Sbjct: 367 HIYSALDPTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRV 426
Query: 357 GRTARIGHGGSALVFLLPMEESYINFL------AINQKCPLQEMKPQRNTADLLPKLKSM 410
GR AR G G+A + P E Y+ L ++ PL+E +L ++
Sbjct: 427 GRVARAGRSGTAYSLVAPDEIPYLLDLHLFLGRSLTLARPLKEPSGVAGVDGMLGRVPQS 486
Query: 411 ALAD---------------RAVFEKGMKAFVSYVQAYAKHECNLIFRLKDLDFASLARGF 455
+ + R + A YV++ I R K++D L
Sbjct: 487 VVDEEDSGLQSTLEASLELRGLARVADNAQQQYVRSRPAPSPESIKRAKEMDLVGLGLHP 546
Query: 456 ALLRMPKMPELRGKQFPDFVP--------VDVNTDTIPFKDKIREKQRQKLLEQQRREKT 507
+ EL+ + D + ++N + ++ +RQK + R +
Sbjct: 547 LFSSRFEEEELQRLRLVDSIKNYRSRATIFEINASSRDLCSQVMRAKRQKDRKAIARFQQ 606
Query: 508 ENEGRRKFIKNKAWSKQKAKKEKKKKMNEKRKREEGSDIED 548
+GR++ + ++K+ ++ + E G +ED
Sbjct: 607 GQQGRQEQQEGPVGPAPSRPALQEKQPEKEEEEEAGESVED 647
>gi|164419743 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 isoform 1
[Homo sapiens]
Length = 882
Score = 168 bits (426), Expect = 1e-41
Identities = 156/581 (26%), Positives = 266/581 (45%), Gaps = 68/581 (11%)
Query: 7 GSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIP 66
G ++S+ + +P G +++ G+ TP+Q TIP+ + KDV A A TGSGKT F++P
Sbjct: 96 GGFQSMGLS-YPVFKGIMKK-GYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTACFLLP 153
Query: 67 ILEILLRREEKLKKSQVGA--IIITPTRELAIQIDEVLSHFTKHFPEFSQI---LWIGGR 121
+ E L K +Q GA +I++PTRELA+Q + FTK +F+ + L +GG
Sbjct: 154 MFERL-----KTHSAQTGARALILSPTRELALQTLK----FTKELGKFTGLKTALILGGD 204
Query: 122 NPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGF 181
ED + +II+ATPGRL + ++++ ++S++ +V DEADRL +MGF
Sbjct: 205 RM-EDQFAALHENPDIIIATPGRLVHV------AVEMSLKLQSVEYVVFDEADRLFEMGF 257
Query: 182 EASINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSR 241
+ I+ LP +T LFSAT + + RAGL PV + + K +
Sbjct: 258 AEQLQEIIARLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVD-------TKLNEQ 310
Query: 242 LENYYMVCKADEKFNQLVHFLRN--HKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCI 299
L+ + + + D K L+H L N Q++ +VF +T EY L L+ ++ C
Sbjct: 311 LKTSFFLVREDTKAAVLLHLLHNVVRPQDQTVVFVATKHHAEY----LTELLTTQRVSCA 366
Query: 300 H--GKMKYKRNKIFM-EFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRC 356
H + KI + +F + L+ TD+ ARG+DIP ++ V+ Y P+ F+HR
Sbjct: 367 HIYSALDPTARKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRV 426
Query: 357 GRTARIGHGGSALVFLLPMEESYINFL------AINQKCPLQEMKPQRNTADLLPKLKSM 410
GR AR G G+A + P E Y+ L ++ PL+E +L ++
Sbjct: 427 GRVARAGRSGTAYSLVAPDEIPYLLDLHLFLGRSLTLARPLKEPSGVAGVDGMLGRVPQS 486
Query: 411 ALAD---------------RAVFEKGMKAFVSYVQAYAKHECNLIFRLKDLDFASLARGF 455
+ + R + A YV++ I R K++D L
Sbjct: 487 VVDEEDSGLQSTLEASLELRGLARVADNAQQQYVRSRPAPSPESIKRAKEMDLVGLGLHP 546
Query: 456 ALLRMPKMPELRGKQFPDFVP--------VDVNTDTIPFKDKIREKQRQKLLEQQRREKT 507
+ EL+ + D + ++N + ++ +RQK + R +
Sbjct: 547 LFSSRFEEEELQRLRLVDSIKNYRSRATIFEINASSRDLCSQVMRAKRQKDRKAIARFQQ 606
Query: 508 ENEGRRKFIKNKAWSKQKAKKEKKKKMNEKRKREEGSDIED 548
+GR++ + ++K+ ++ + E G +ED
Sbjct: 607 GQQGRQEQQEGPVGPAPSRPALQEKQPEKEEEEEAGESVED 647
>gi|7661920 eukaryotic translation initiation factor 4A, isoform 3
[Homo sapiens]
Length = 411
Score = 167 bits (424), Expect = 2e-41
Identities = 114/391 (29%), Positives = 196/391 (50%), Gaps = 26/391 (6%)
Query: 16 LHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRRE 75
L +L + GF + +Q I ++ +DV A++ +G+GKT F I +L+ L
Sbjct: 45 LREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCL---- 100
Query: 76 EKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGG 135
++ + A+I+ PTRELA+QI + L + IGG N GED+ + G
Sbjct: 101 -DIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHAC-IGGTNVGEDIRKL-DYGQ 157
Query: 136 NIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQ 195
+++ TPGR+ DM RR++ R++ +LVLDEAD +L+ GF+ I + +LP
Sbjct: 158 HVVAGTPGRVFDMIRRRSLR------TRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPA 211
Query: 196 RRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADE-K 254
+ L SAT E+ + + +P+R+ VK + T ++ +++ + +E K
Sbjct: 212 TQVVLISATLPHEILEMTNKFMTDPIRILVKRD-------ELTLEGIKQFFVAVEREEWK 264
Query: 255 FNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKYK-RNKIFME 313
F+ L + ++F +T V++ + + + +HG M K R I E
Sbjct: 265 FDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA--NFTVSSMHGDMPQKERESIMKE 322
Query: 314 FRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLL 373
FR S +L+ TDV ARG+D+P+V+ ++ YD P+N ++HR GR+ R G G A+ F+
Sbjct: 323 FRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVK 382
Query: 374 PMEESYINFLAINQKCPLQEMKPQRNTADLL 404
+ + + + EM N ADL+
Sbjct: 383 NDDIRILRDIEQYYSTQIDEM--PMNVADLI 411
>gi|188035877 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 [Homo
sapiens]
Length = 619
Score = 167 bits (423), Expect = 3e-41
Identities = 116/359 (32%), Positives = 186/359 (51%), Gaps = 24/359 (6%)
Query: 18 PQVLGA-LRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREE 76
P+VL L++ G+ TP+Q IP+ + +D+ A A TGSGKT AF++P++ L
Sbjct: 211 PEVLNHNLKKSGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRAL---- 266
Query: 77 KLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGN 136
+ A+I+TPTRELAIQI+ P +L +GG + R QQ
Sbjct: 267 -FESKTPSALILTPTRELAIQIERQAKELMSGLPRMKTVLLVGGLPLPPQLYRL-QQHVK 324
Query: 137 IIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQR 196
+I+ATPGRL D+ ++ + L C + ++V+DEAD +L MGF+ + ILE +P
Sbjct: 325 VIIATPGRLLDIIKQSSVEL----C--GVKIVVVDEADTMLKMGFQQQVLDILENIPNDC 378
Query: 197 RTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFN 256
+T L SAT +E L L NPVR+ EK + ++ ++ +E+ K
Sbjct: 379 QTILVSATIPTSIEQLASQLLHNPVRIITGEKNLPCANVRQIILWVED-------PAKKK 431
Query: 257 QLVHFLRNHKQEKH--LVFFSTCACVEYYGKALEVLVKGVKIMCIHG-KMKYKRNKIFME 313
+L L + K K LVF + +A++ + G+K + IH K + +R I
Sbjct: 432 KLFEILNDKKLFKPPVLVFVDCKLGADLLSEAVQ-KITGLKSISIHSEKSQIERKNILKG 490
Query: 314 FRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFL 372
+ ++V T V+ RG+D+ V V+ +D PS+ +VH+ GR R+G G+A+ F+
Sbjct: 491 LLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIGRVGRLGQNGTAITFI 549
>gi|209862869 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 3
[Homo sapiens]
Length = 724
Score = 163 bits (413), Expect = 4e-40
Identities = 122/360 (33%), Positives = 192/360 (53%), Gaps = 31/360 (8%)
Query: 24 LRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLR------REEK 77
+ + G+ +TPVQ +IP+ + +D+ A A TGSGKT AF++PIL ++ R ++
Sbjct: 303 IAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKE 362
Query: 78 LKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNI 137
L++ + II+ PTREL QI F+ + +++ GG G + + Q G NI
Sbjct: 363 LQEPE--CIIVAPTRELVNQIYLEARKFSFGTCVRAVVIY-GGTQLGHSIRQIVQ-GCNI 418
Query: 138 IVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEF--LP-- 193
+ ATPGRL D+ ++ GL + + LVLDEADR+LDMGF + ++ +P
Sbjct: 419 LCATPGRLMDIIGKEKIGL------KQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSK 472
Query: 194 KQRRTGLFSATQTQEVENLVRAGLR-NPVRVSVKEKGVAASSAQKTPSRLENYYMVCKAD 252
+QR+T +FSAT +E++ L L+ N + V+V + G A Q+T ++ +
Sbjct: 473 EQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQF------- 525
Query: 253 EKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKYK-RNKIF 311
K +LV LRN E+ +VF T ++ L + + IHG + + R +
Sbjct: 526 SKREKLVEILRNIGDERTMVFVETKKKADFIATFL--CQEKISTTSIHGDREQREREQAL 583
Query: 312 MEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVF 371
+FR + +LV T V ARG+DI V V+ +D PS +VHR GRT R G+ G A+ F
Sbjct: 584 GDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISF 643
>gi|13518015 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 1
[Homo sapiens]
Length = 724
Score = 163 bits (413), Expect = 4e-40
Identities = 122/360 (33%), Positives = 192/360 (53%), Gaps = 31/360 (8%)
Query: 24 LRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLR------REEK 77
+ + G+ +TPVQ +IP+ + +D+ A A TGSGKT AF++PIL ++ R ++
Sbjct: 303 IAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKE 362
Query: 78 LKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNI 137
L++ + II+ PTREL QI F+ + +++ GG G + + Q G NI
Sbjct: 363 LQEPE--CIIVAPTRELVNQIYLEARKFSFGTCVRAVVIY-GGTQLGHSIRQIVQ-GCNI 418
Query: 138 IVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEF--LP-- 193
+ ATPGRL D+ ++ GL + + LVLDEADR+LDMGF + ++ +P
Sbjct: 419 LCATPGRLMDIIGKEKIGL------KQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSK 472
Query: 194 KQRRTGLFSATQTQEVENLVRAGLR-NPVRVSVKEKGVAASSAQKTPSRLENYYMVCKAD 252
+QR+T +FSAT +E++ L L+ N + V+V + G A Q+T ++ +
Sbjct: 473 EQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQF------- 525
Query: 253 EKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKYK-RNKIF 311
K +LV LRN E+ +VF T ++ L + + IHG + + R +
Sbjct: 526 SKREKLVEILRNIGDERTMVFVETKKKADFIATFL--CQEKISTTSIHGDREQREREQAL 583
Query: 312 MEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVF 371
+FR + +LV T V ARG+DI V V+ +D PS +VHR GRT R G+ G A+ F
Sbjct: 584 GDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISF 643
>gi|216548263 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform 2
[Homo sapiens]
Length = 690
Score = 163 bits (413), Expect = 4e-40
Identities = 122/360 (33%), Positives = 192/360 (53%), Gaps = 31/360 (8%)
Query: 24 LRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLR------REEK 77
+ + G+ +TPVQ +IP+ + +D+ A A TGSGKT AF++PIL ++ R ++
Sbjct: 269 IAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKE 328
Query: 78 LKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNI 137
L++ + II+ PTREL QI F+ + +++ GG G + + Q G NI
Sbjct: 329 LQEPE--CIIVAPTRELVNQIYLEARKFSFGTCVRAVVIY-GGTQLGHSIRQIVQ-GCNI 384
Query: 138 IVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEF--LP-- 193
+ ATPGRL D+ ++ GL + + LVLDEADR+LDMGF + ++ +P
Sbjct: 385 LCATPGRLMDIIGKEKIGL------KQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSK 438
Query: 194 KQRRTGLFSATQTQEVENLVRAGLR-NPVRVSVKEKGVAASSAQKTPSRLENYYMVCKAD 252
+QR+T +FSAT +E++ L L+ N + V+V + G A Q+T ++ +
Sbjct: 439 EQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQF------- 491
Query: 253 EKFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIMCIHGKMKYK-RNKIF 311
K +LV LRN E+ +VF T ++ L + + IHG + + R +
Sbjct: 492 SKREKLVEILRNIGDERTMVFVETKKKADFIATFL--CQEKISTTSIHGDREQREREQAL 549
Query: 312 MEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVF 371
+FR + +LV T V ARG+DI V V+ +D PS +VHR GRT R G+ G A+ F
Sbjct: 550 GDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISF 609
>gi|4503529 eukaryotic translation initiation factor 4A isoform 1
[Homo sapiens]
Length = 406
Score = 161 bits (407), Expect = 2e-39
Identities = 118/410 (28%), Positives = 202/410 (49%), Gaps = 30/410 (7%)
Query: 2 EHVTEGSWESL-----PVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTG 56
E V E +W + + L +L + GF + +Q I ++ DV A+A +G
Sbjct: 20 EGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSG 79
Query: 57 SGKTLAFVIPILEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQIL 116
+GKT F I IL+ + E LK +Q A+++ PTRELA QI +V+ +
Sbjct: 80 TGKTATFAISILQQI---ELDLKATQ--ALVLAPTRELAQQIQKVVMALGDYMGASCHAC 134
Query: 117 WIGGRNPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRL 176
IGG N +V++ + + +IIV TPGR+ DM R+ + + + VLDEAD +
Sbjct: 135 -IGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLS------PKYIKMFVLDEADEM 187
Query: 177 LDMGFEASINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQ 236
L GF+ I I + L + L SAT +V + + +R+P+R+ VK++ +
Sbjct: 188 LSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKE-------E 240
Query: 237 KTPSRLENYYMVCKADE-KFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVK 295
T + +Y+ + +E K + L + ++F +T V++ + + +
Sbjct: 241 LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHA--RDFT 298
Query: 296 IMCIHGKMKYKRNKIFM-EFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVH 354
+ +HG M K + M EFR S +L+ TD++ARGID+ +V+ V+ YD P+N ++H
Sbjct: 299 VSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIH 358
Query: 355 RCGRTARIGHGGSALVFLLPMEESYINFLAINQKCPLQEMKPQRNTADLL 404
R GR R G G A+ + ++ + + ++EM N ADL+
Sbjct: 359 RIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEM--PLNVADLI 406
>gi|83700235 eukaryotic translation initiation factor 4A2 [Homo
sapiens]
Length = 407
Score = 160 bits (406), Expect = 2e-39
Identities = 116/408 (28%), Positives = 204/408 (50%), Gaps = 30/408 (7%)
Query: 4 VTEGSWESL-----PVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSG 58
V E +W + + L +L + GF + +Q I ++ DV A+A +G+G
Sbjct: 23 VIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTG 82
Query: 59 KTLAFVIPILEILLRREEKLKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWI 118
KT F I IL+ L E + K++Q A+++ PTRELA QI +V+ + I
Sbjct: 83 KTATFAISILQQL---EIEFKETQ--ALVLAPTRELAQQIQKVILALGDYMGATCHAC-I 136
Query: 119 GGRNPGEDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLD 178
GG N ++++ + + +I+V TPGR+ DM R+ + + + VLDEAD +L
Sbjct: 137 GGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLS------PKWIKMFVLDEADEMLS 190
Query: 179 MGFEASINTILEFLPKQRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKT 238
GF+ I I + L + L SAT +V + + +R+P+R+ VK++ + T
Sbjct: 191 RGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKE-------ELT 243
Query: 239 PSRLENYYMVCKADE-KFNQLVHFLRNHKQEKHLVFFSTCACVEYYGKALEVLVKGVKIM 297
++ +Y+ + +E K + L + ++F +T V++ + + + +
Sbjct: 244 LEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHA--RDFTVS 301
Query: 298 CIHGKMKYKRNKIFM-EFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRC 356
+HG M K + M EFR S +L+ TD++ARGID+ +V+ V+ YD P+N ++HR
Sbjct: 302 ALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI 361
Query: 357 GRTARIGHGGSALVFLLPMEESYINFLAINQKCPLQEMKPQRNTADLL 404
GR R G G A+ F+ ++ + + ++EM N ADL+
Sbjct: 362 GRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEM--PMNVADLI 407
>gi|4758138 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 [Homo sapiens]
Length = 614
Score = 159 bits (403), Expect = 5e-39
Identities = 112/357 (31%), Positives = 185/357 (51%), Gaps = 16/357 (4%)
Query: 20 VLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPILEILLRREEKLK 79
V+ + F T +Q+ P+ + D+ A TGSGKTL++++P + + + +
Sbjct: 105 VMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLER 164
Query: 80 KSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGEDVERFKQQGGNIIV 139
+++ PTRELA Q+ +V + + + S ++ GG G + R ++G I +
Sbjct: 165 GDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIY-GGAPKGPQI-RDLERGVEICI 222
Query: 140 ATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASINTILEFLPKQRRTG 199
ATPGRL D L R LVLDEADR+LDMGFE I I++ + R+T
Sbjct: 223 ATPGRLIDFLECGKTNL------RRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTL 276
Query: 200 LFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRLENYYMVCKADEKFNQLV 259
++SAT +EV L L++ + +++ G SA ++ + + DEK +L+
Sbjct: 277 MWSATWPKEVRQLAEDFLKDYIHINI---GALELSANHNILQIVDVCHDVEKDEKLIRLM 333
Query: 260 HFLRNHKQEKHLVFFSTCA-CVEYYGKALEVLVKGVKIMCIHG-KMKYKRNKIFMEFRKL 317
+ + K+ K +VF T C E K G M IHG K + +R+ + EF+
Sbjct: 334 EEIMSEKENKTIVFVETKRRCDELTRKMRR---DGWPAMGIHGDKSQQERDWVLNEFKHG 390
Query: 318 QSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGRTARIGHGGSALVFLLP 374
++ IL+ TDV +RG+D+ +V +V+ YD P+++ ++HR GRTAR G+A F P
Sbjct: 391 KAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTP 447
>gi|87196351 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3 [Homo
sapiens]
Length = 662
Score = 156 bits (395), Expect = 4e-38
Identities = 129/373 (34%), Positives = 187/373 (50%), Gaps = 40/373 (10%)
Query: 20 VLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPIL---------EI 70
++G + + TPVQ IP+ +D+ A A TGSGKT AF++PIL E
Sbjct: 191 IMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEA 250
Query: 71 LLRREEK----LKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGED 126
L +E +K ++++ PTRELA+QI E F+ +++ GG + G+
Sbjct: 251 LRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVY-GGADIGQQ 309
Query: 127 VERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASIN 186
+ R ++G +++VATPGRL DM R GLD LVLDEADR+LDMGFE I
Sbjct: 310 I-RDLERGCHLLVATPGRLVDMMERGKIGLDFCK------YLVLDEADRMLDMGFEPQIR 362
Query: 187 TILE---FLPKQ-RRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRL 242
I+E PK R T +FSAT +E++ L R L + ++V G T +
Sbjct: 363 RIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVG-------STSENI 415
Query: 243 ENYYMVCKADEKFNQLVHFLR-NHKQEKHLVFFSTCACVEYYGKALEVLV--KGVKIMCI 299
+ + +K + L+ L K LVF T + +LE + +G I
Sbjct: 416 TQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGAD----SLEDFLYHEGYACTSI 471
Query: 300 HGKMKYK-RNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGR 358
HG + R + +FR +S ILV T V ARG+DI V V+ +D PS+ +VHR GR
Sbjct: 472 HGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGR 531
Query: 359 TARIGHGGSALVF 371
T R+G+ G A F
Sbjct: 532 TGRVGNLGLATSF 544
>gi|13129006 nucleolar protein GU2 [Homo sapiens]
Length = 737
Score = 154 bits (389), Expect = 2e-37
Identities = 113/387 (29%), Positives = 199/387 (51%), Gaps = 28/387 (7%)
Query: 6 EGSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVI 65
EG++ + P+ + + L+ G Y+ P+Q T KD+ A+A TG+GKT +F I
Sbjct: 136 EGAFSNFPIS--EETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAI 193
Query: 66 PILEILLRREEKLKKSQVGAIII-TPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPG 124
P++E L R +E +KKS+ +++ PTRELA Q+ + T+ + S + GG +
Sbjct: 194 PLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITR---KLSVACFYGGTSYQ 250
Query: 125 EDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEAS 184
+ + G +I+V TPGR++D + + LDL+ L +VLDE D++LD+GF
Sbjct: 251 SQINHIRN-GIDILVGTPGRIKDHLQ--SGRLDLSK----LRHVVLDEVDQMLDLGFAEQ 303
Query: 185 INTILEFLPK-----QRRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTP 239
+ I+ K +T LFSAT Q V + + +++ ++ + QK
Sbjct: 304 VEDIIHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKS----RYEQVDLVGKMTQKAA 359
Query: 240 SRLENYYMVCKADEKFNQLVHFLRNHK--QEKHLVFFSTCACVEYYGKALEVLVKGVKIM 297
+ +E+ + C ++ + L+ + + + ++F T V A+ +K
Sbjct: 360 TTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEM--AMNPHIKQ-NAQ 416
Query: 298 CIHGKMKYKRNKIFME-FRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRC 356
C+HG + + +I ++ FR+ +LV T+V ARG+DIPEV+ V+Q PP + +++HR
Sbjct: 417 CLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRS 476
Query: 357 GRTARIGHGGSALVFLLPMEESYINFL 383
GRT R G G + F P E + ++
Sbjct: 477 GRTGRAGRTGICICFYQPRERGQLRYV 503
>gi|50659095 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Homo
sapiens]
Length = 783
Score = 154 bits (389), Expect = 2e-37
Identities = 118/385 (30%), Positives = 195/385 (50%), Gaps = 36/385 (9%)
Query: 6 EGSWESLPVPLHPQVLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVI 65
EG++ + P+ + + L+ G ++ P+Q+ T KD+ A+A TG+GKT +F I
Sbjct: 185 EGAFSNFPIS--EETIKLLKGRGVTFLFPIQAKTFHHVYSGKDLIAQARTGTGKTFSFAI 242
Query: 66 PILEILLRREEKLKKSQVGAIII-TPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPG 124
P++E L + K+ + +++ PTRELA Q+ + S TK + S + GG G
Sbjct: 243 PLIEKLHGELQDRKRGRAPQVLVLAPTRELANQVSKDFSDITK---KLSVACFYGGTPYG 299
Query: 125 EDVERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEAS 184
ER + G +I+V TPGR++D + LDL L +VLDE D++LDMGF
Sbjct: 300 GQFERMRN-GIDILVGTPGRIKDHIQNGK--LDLTK----LKHVVLDEVDQMLDMGFADQ 352
Query: 185 INTILEFLPKQR-----RTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTP 239
+ IL K+ +T LFSAT V N+ + +++ + ++ + QKT
Sbjct: 353 VEEILSVAYKKDSEDNPQTLLFSATCPHWVFNVAKKYMKS----TYEQVDLIGKKTQKTA 408
Query: 240 SRLENYYMVCKADEKFNQLVHFLRNHK--QEKHLVFFSTCACVEYYGKALEVLVKGVKI- 296
+E+ + C ++ + +R + Q + ++F T K + L + I
Sbjct: 409 ITVEHLAIKCHWTQRAAVIGDVIRVYSGHQGRTIIFCET-------KKEAQELSQNSAIK 461
Query: 297 ---MCIHGKMKYKRNKIFME-FRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAF 352
+HG + K+ +I ++ FR G+LV T+V ARG+DIPEV+ V+Q PP + ++
Sbjct: 462 QDAQSLHGDIPQKQREITLKGFRNGSFGVLVATNVAARGLDIPEVDLVIQSSPPKDVESY 521
Query: 353 VHRCGRTARIGHGGSALVFLLPMEE 377
+HR GRT R G G + F EE
Sbjct: 522 IHRSGRTGRAGRTGVCICFYQHKEE 546
>gi|169881239 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
[Homo sapiens]
Length = 660
Score = 152 bits (383), Expect = 1e-36
Identities = 128/373 (34%), Positives = 188/373 (50%), Gaps = 40/373 (10%)
Query: 20 VLGALRELGFPYMTPVQSATIPLFMRNKDVAAEAVTGSGKTLAFVIPIL---------EI 70
++G + + TPVQ IP+ +D+ A A TGSGKT AF++PIL E
Sbjct: 189 IMGNIELTRYTRPTPVQKHAIPIIKGKRDLMACAQTGSGKTAAFLLPILSQIYTDGPGEA 248
Query: 71 LLRREEK----LKKSQVGAIIITPTRELAIQIDEVLSHFTKHFPEFSQILWIGGRNPGED 126
L +E +K ++++ PTRELA+QI E F+ +++ GG + G+
Sbjct: 249 LKAVKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVY-GGADIGQQ 307
Query: 127 VERFKQQGGNIIVATPGRLEDMFRRKAEGLDLASCVRSLDVLVLDEADRLLDMGFEASIN 186
+ R ++G +++VATPGRL DM R GLD LVLDEADR+LDMGFE I
Sbjct: 308 I-RDLERGCHLLVATPGRLVDMMERGKIGLDFCK------YLVLDEADRMLDMGFEPQIR 360
Query: 187 TILE---FLPKQ-RRTGLFSATQTQEVENLVRAGLRNPVRVSVKEKGVAASSAQKTPSRL 242
I+E PK R T +FSAT +E++ L R L + ++V G + + + +
Sbjct: 361 RIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWV 420
Query: 243 ENYYMVCKADEKFNQLVHFL-RNHKQEKHLVFFSTCACVEYYGKALEVLV--KGVKIMCI 299
E+ +K + L+ L LVF T + +LE + +G I
Sbjct: 421 EDL-------DKRSFLLDILGATGSDSLTLVFVETKKGAD----SLEDFLYHEGYACTSI 469
Query: 300 HGKMKYK-RNKIFMEFRKLQSGILVCTDVMARGIDIPEVNWVLQYDPPSNASAFVHRCGR 358
HG + R + +FR +S ILV T V ARG+DI V V+ +D PS+ +VHR GR
Sbjct: 470 HGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGR 529
Query: 359 TARIGHGGSALVF 371
T R+G+ G A F
Sbjct: 530 TGRVGNLGLATSF 542
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,988,558
Number of Sequences: 37866
Number of extensions: 991872
Number of successful extensions: 12413
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 305
Number of HSP's successfully gapped in prelim test: 349
Number of HSP's that attempted gapping in prelim test: 6519
Number of HSP's gapped (non-prelim): 3798
length of query: 600
length of database: 18,247,518
effective HSP length: 108
effective length of query: 492
effective length of database: 14,157,990
effective search space: 6965731080
effective search space used: 6965731080
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.