Search of human proteins with 41327726

Search of human proteins with 41327726

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
precursor [Homo sapiens]
         (501 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...  1019   0.0  
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]     379   e-105
gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide p...   374   e-103
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...   369   e-102
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...   366   e-101
gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide ...   350   2e-96
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...   347   1e-95
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]   343   2e-94
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]    329   3e-90
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...   317   2e-86
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...   316   4e-86
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...   313   2e-85
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...   300   2e-81
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]   300   3e-81
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...   270   2e-72
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...   242   5e-64
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...   234   2e-61
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]              208   8e-54
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   186   3e-47
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   186   3e-47
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...   172   5e-43
gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]              159   6e-39
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   148   1e-35
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   144   2e-34
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...   124   2e-28
gi|4504023 glycine receptor, beta [Homo sapiens]                       84   2e-16
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]        84   3e-16
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]          84   3e-16
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]        84   4e-16
gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]        83   5e-16

>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score = 1019 bits (2634), Expect = 0.0
 Identities = 501/501 (100%), Positives = 501/501 (100%)

Query: 1   MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLIL 60
           MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLIL
Sbjct: 1   MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLIL 60

Query: 61  AQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNND 120
           AQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNND
Sbjct: 61  AQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNND 120

Query: 121 GNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS 180
           GNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS
Sbjct: 121 GNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS 180

Query: 181 LQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLI 240
           LQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLI
Sbjct: 181 LQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLI 240

Query: 241 IRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPE 300
           IRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPE
Sbjct: 241 IRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPE 300

Query: 301 TSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRL 360
           TSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRL
Sbjct: 301 TSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRL 360

Query: 361 KRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFI 420
           KRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFI
Sbjct: 361 KRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFI 420

Query: 421 DGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTS 480
           DGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTS
Sbjct: 421 DGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTS 480

Query: 481 VGTLVIFLDATYHLPPPDPFP 501
           VGTLVIFLDATYHLPPPDPFP
Sbjct: 481 VGTLVIFLDATYHLPPPDPFP 501


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score =  379 bits (972), Expect = e-105
 Identities = 205/482 (42%), Positives = 295/482 (61%), Gaps = 39/482 (8%)

Query: 22  RGSEAEGRLREKLFSG--YDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYL 79
           R + AE +L + L +   Y++ +RPA      + + + L LAQLIS+NE+++ M+T V+L
Sbjct: 22  RVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNEREQIMTTNVWL 81

Query: 80  DLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSV 139
             EWTDYRL+W+ + ++G++ LRI A+ +WLPD+VL NN DG ++V++  +++V S+GSV
Sbjct: 82  KQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIVRSNGSV 141

Query: 140 RWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHE 199
            W PP IY+S+C I+V YFPFD QNCT+ F S++YD +E+ +   + P            
Sbjct: 142 LWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVL-MTPTASMDD------ 194

Query: 200 GTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILI 259
             F  +G+W+I+  P R    P DP         +V +  II+RKPLFY +N+I PC+L 
Sbjct: 195 --FTPSGEWDIVALPGRRTVNPQDP------SYVDVTYDFIIKRKPLFYTINLIIPCVLT 246

Query: 260 TLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLV 319
           TLLAI VFYLP D GEKM L I  LL LT FLLL++  VP TSL VP+I KYLMFTMVLV
Sbjct: 247 TLLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLV 306

Query: 320 TFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERD---LMPEPPHC 376
           TFS++ SV VLN+HHRSP TH M  WV++ F+HKLP +L +KRP P+       P    C
Sbjct: 307 TFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRPGPDSSPARAFPPSKSC 366

Query: 377 ----------SSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRA 426
                     +SP + +G     YF+   P+      P    P     D      G  R 
Sbjct: 367 VTKPEATATSTSPSNFYGNSM--YFVN--PASAASKSPAGSTPVAIPRDFWLRSSGRFR- 421

Query: 427 VALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVI 486
                +++E +  +S+IA+ ++  ++  ++ EDW++VAMVVDRLFLW F+    +GT+ +
Sbjct: 422 ----QDVQEALEGVSFIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGL 477

Query: 487 FL 488
           FL
Sbjct: 478 FL 479


>gi|61743914 cholinergic receptor, nicotinic, gamma polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  374 bits (959), Expect = e-103
 Identities = 214/509 (42%), Positives = 302/509 (59%), Gaps = 19/509 (3%)

Query: 4   GALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQL 63
           G LL+LL  L   L  G +G   E RL   L   YD ++RPA    D V VS+ L L  L
Sbjct: 6   GPLLLLL-LLAVCL--GAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNL 62

Query: 64  ISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNF 123
           ISLNE++E ++T V+++++W DYRL WDP +++G+  LR+ +  VW PD+VL NN DG F
Sbjct: 63  ISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVF 122

Query: 124 DVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQT 183
           +VAL  +V+VS DG + W PP I+RS+CSI VTYFPFDWQNC+++F S +Y ++E+ LQ 
Sbjct: 123 EVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQL 182

Query: 184 GLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRR 243
               DGQ  + I I    F ENG+W I H+P++++  P  P   +E   Q+V+FYL+I+R
Sbjct: 183 S-QEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAP--AQEAGHQKVVFYLLIQR 239

Query: 244 KPLFYLVNVIAPCILITLLAIFVFYLPPDA-GEKMGLSIFALLTLTVFLLLLADKVPETS 302
           KPLFY++N+IAPC+LI+ +AI + +LP  A G+K  ++I  LL  TVFL L+A KVPETS
Sbjct: 240 KPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETS 299

Query: 303 LSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLK- 361
            +VP+I KYL F +V+    V+ +VVVLN+  RSPHTH M   VR++F+  LP  LR+  
Sbjct: 300 QAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHV 359

Query: 362 RPKPERDLMPEPPHCSSPGSGWGRGT-DEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFI 420
           RP     +        +  SGW   T +E  +  P S+ LF +  R    L A  L +  
Sbjct: 360 RPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQR--QGLVAAALEKLE 417

Query: 421 DGPNRAVA--------LLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFL 472
            GP   ++          P ++  V + + IA    +Q   D   E+W  V  V+DR+  
Sbjct: 418 KGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCF 477

Query: 473 WTFIIFTSVGTLVIFLDATYHLPPPDPFP 501
              +     GT  IFL A Y+  P  PFP
Sbjct: 478 LAMLSLFICGTAGIFLMAHYNRVPALPFP 506


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score =  369 bits (946), Expect = e-102
 Identities = 212/502 (42%), Positives = 296/502 (58%), Gaps = 37/502 (7%)

Query: 4   GALLMLLGALGAPLAPGVRGSEAEGRLREKLF--SGYDSSVRPAREVGDRVRVSVGLILA 61
           G + +LLG     L  GV G++ E RL E L   S Y+  +RPA    + V V + + LA
Sbjct: 6   GPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLA 65

Query: 62  QLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDG 121
           QLIS++E+++ M+T V+L  EW DYRL+W P E D +  +R+ ++ +WLPDVVL NN DG
Sbjct: 66  QLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADG 125

Query: 122 NFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSL 181
            ++V+   + VVS DGS+ W PP IY+S+C I+V +FPFD QNCTM F S++YD +E+ L
Sbjct: 126 MYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDL 185

Query: 182 QTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLII 241
                       E+   +  F  +G+W+I+  P R  + P D          ++ +  II
Sbjct: 186 VL--------KSEVASLDD-FTPSGEWDIVALPGRRNENPDD------STYVDITYDFII 230

Query: 242 RRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPET 301
           RRKPLFY +N+I PC+LIT LAI VFYLP D GEKM L I  LL LTVFLLL++  VP T
Sbjct: 231 RRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPT 290

Query: 302 SLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLK 361
           SL VP++ KYLMFTMVLVTFS++ SV VLN+HHRSP TH M  WV+ +F+ KLP  L ++
Sbjct: 291 SLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQ 350

Query: 362 RPKPERDLMPEPPHCSSPGSGWGRGTDE-------YFIRKPPSDFLFPKPNRFQPELSAP 414
           +P+          HC+       R   E       +F   P +D      NR   +  A 
Sbjct: 351 QPR---------HHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVNRASVQGLAG 401

Query: 415 DLRRF---IDGPNRAVALLP-ELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRL 470
                   + GP R+       LRE V  + +IA  ++ ++D  ++ EDW++VAMV+DRL
Sbjct: 402 AFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRL 461

Query: 471 FLWTFIIFTSVGTLVIFLDATY 492
           FLW F+     GT+ +FL   +
Sbjct: 462 FLWIFVFVCVFGTIGMFLQPLF 483


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score =  366 bits (940), Expect = e-101
 Identities = 205/504 (40%), Positives = 295/504 (58%), Gaps = 14/504 (2%)

Query: 7   LMLLGALGAPLAPGVRGSEAEGRLREKLFS--GYDSSVRPAREVGDRVRVSVGLILAQLI 64
           ++ LG L A    G  G   E RL   LF   GY+  +RP     + V V++ L L+ LI
Sbjct: 5   VLTLGLLAALAVCGSWGLNEEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLI 64

Query: 65  SLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFD 124
           SL E +E ++T V+++  WTD RL W+  E   I  LR+  + VWLP++VL NNNDG+F 
Sbjct: 65  SLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQ 124

Query: 125 VALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTG 184
           ++   +V+V   G V W PP I+RSSC I VTYFPFDWQNC++ FSS  Y + E++L   
Sbjct: 125 ISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITL--S 182

Query: 185 LGPDGQGHQE-----IHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYL 239
           L  D + ++      I I    F ENG+WEI+H+P+R+   P  P       RQ++ FYL
Sbjct: 183 LKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLD--SPSRQDITFYL 240

Query: 240 IIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVP 299
           IIRRKPLFY++N++ PC+LI+ +   VFYLP D+GEK  ++I  LL  +VFLLL++ ++P
Sbjct: 241 IIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLP 300

Query: 300 ETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLR 359
            TS+++P+I K+L+F MVLVT  V++ V+VLN+H R+P TH +   V+++F+  LP  L 
Sbjct: 301 ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGVKKLFLETLPELLH 360

Query: 360 LKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPN-RFQPELSAPDLRR 418
           + RP  E    P      S   G+    +EYF+ K  SD +F K + R          RR
Sbjct: 361 MSRP-AEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLTTARR 419

Query: 419 FIDGPNRA-VALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFII 477
                 +A   L  EL+  V   ++I   +++Q +++  K+ W  VA  VDRL L+    
Sbjct: 420 PPASSEQAQQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDRLCLFVVTP 479

Query: 478 FTSVGTLVIFLDATYHLPPPDPFP 501
              VGT  IFL   Y+ PPP PFP
Sbjct: 480 VMVVGTAWIFLQGVYNQPPPQPFP 503


>gi|4557463 nicotinic acetylcholine receptor epsilon polypeptide
           precursor [Homo sapiens]
          Length = 493

 Score =  350 bits (897), Expect = 2e-96
 Identities = 196/500 (39%), Positives = 292/500 (58%), Gaps = 19/500 (3%)

Query: 3   PGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQ 62
           P  +L+LLG LG  +     G   E RL   LF+ YD   RP RE  D V +S+ + L  
Sbjct: 5   PLGVLLLLGLLGRGV-----GKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTN 59

Query: 63  LISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGN 122
           LISLNEK+E ++T V++ ++W DYRL++   +  GI++LR+ +E VWLP++VL NN DG 
Sbjct: 60  LISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQ 119

Query: 123 FDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQ 182
           F VA D +V+V   GSV W PP IYRS C+++VTYFPFDWQNC+++F S +Y++ EV   
Sbjct: 120 FGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFT 179

Query: 183 TGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQ-EVIFYLII 241
             +  DG+   +I I    + ENG+W I   P  + +  G   G  +G  + +VI+ LII
Sbjct: 180 FAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHG---GATDGPGETDVIYSLII 236

Query: 242 RRKPLFYLVNVIAPCILITLLAIFVFYLPPDA-GEKMGLSIFALLTLTVFLLLLADKVPE 300
           RRKPLFY++N+I PC+LI+ L +  ++LP  A G+K  +SI  LL  TVFL L+A K+PE
Sbjct: 237 RRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPE 296

Query: 301 TSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRL 360
           TSLSVP++ ++L+F MV+ T  V+  V+VLN+  R+P TH M   +R + +  LP  L  
Sbjct: 297 TSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLG- 355

Query: 361 KRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFI 420
             P PE      PP  +S   G     +E  ++KP S+ +F      Q   +A   +   
Sbjct: 356 SPPPPEAPRAASPPRRAS-SVGLLLRAEELILKKPRSELVFEGQRHRQGTWTAAFCQSL- 413

Query: 421 DGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTS 480
                  A  PE+R  V +++++A   ++QE       DW  +   +D +  W  ++  S
Sbjct: 414 ------GAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFS 467

Query: 481 VGTLVIFLDATYHLPPPDPF 500
           VG+ +IFL A ++  P  P+
Sbjct: 468 VGSSLIFLGAYFNRVPDLPY 487


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score =  347 bits (891), Expect = 1e-95
 Identities = 190/487 (39%), Positives = 276/487 (56%), Gaps = 29/487 (5%)

Query: 17  LAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTK 76
           L  G   +E E RL + LF GY+   RP     D V V  GL +AQLI ++EK++ M+T 
Sbjct: 49  LPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTN 108

Query: 77  VYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSD 136
           V+L  EW+DY+L W+P +   I SLR+ +E +W+PD+VL NN DG F V       + S 
Sbjct: 109 VWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFST 168

Query: 137 GSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIH 196
           G+V W PP IY+SSCSI VT+FPFD QNC M F S++YD +++ L+       Q  Q + 
Sbjct: 169 GTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLE-------QMEQTVD 221

Query: 197 IHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPC 256
           + +  + E+G+W I++          D          +V +  +IRR PLFY +N+I PC
Sbjct: 222 LKD--YWESGEWAIVNATGTYNSKKYDCCA---EIYPDVTYAFVIRRLPLFYTINLIIPC 276

Query: 257 ILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTM 316
           +LI+ L + VFYLP D GEK+ L I  LL+LTVFLLL+ + +P TSL +P+I +YL+FTM
Sbjct: 277 LLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTM 336

Query: 317 VLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHC 376
           + VT S++++V VLN+HHRSP TH MP WVR   +  +P +L + RP P  +L       
Sbjct: 337 IFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLK 396

Query: 377 SSPGSGWGRGTDEYFIRK---------------PPSDFLFPKPNRFQPELSAPDLRRFID 421
            SP   W     +   R+                PS              S P     + 
Sbjct: 397 LSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQ 456

Query: 422 GPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSV 481
                + L P +++ +  + YIA  L+ ++   ++KEDW++VAMV+DR+FLW FII   +
Sbjct: 457 --EGELLLSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFL 514

Query: 482 GTLVIFL 488
           GT+ +FL
Sbjct: 515 GTIGLFL 521


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score =  343 bits (881), Expect = 2e-94
 Identities = 187/501 (37%), Positives = 286/501 (57%), Gaps = 34/501 (6%)

Query: 3   PGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQ 62
           P  LL+LL      L P  R SEAE RL E+LF  Y+  +RP   V D V +   + ++Q
Sbjct: 15  PRLLLLLL----LSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQ 70

Query: 63  LISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGN 122
           L+ ++E ++ M T ++L   W DY+L W+P+++ G + +R+ A+ +W PD+VL NN  G+
Sbjct: 71  LVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGD 130

Query: 123 FDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQ 182
           F V      ++   G V W PP I++SSC I VTYFPFD+QNCTM F S+SYD +++ L 
Sbjct: 131 FQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLV 190

Query: 183 TGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIR 242
             +G          ++   + E+G+W II  P              E    ++ + L IR
Sbjct: 191 L-IGSS--------MNLKDYWESGEWAIIKAPG---YKHDIKYNCCEEIYPDITYSLYIR 238

Query: 243 RKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETS 302
           R PLFY +N+I PC+LI+ L + VFYLP D GEK+ L I  LL+LTVFLL++ + +P TS
Sbjct: 239 RLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTS 298

Query: 303 LSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKR 362
           L +P+I +YL+FTM+ VT S++++V VLN+H+R+P TH MP WV+ +F++ LP  + + R
Sbjct: 299 LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTR 358

Query: 363 P--------KPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFP-------KPNRF 407
           P        KP      E  + +       +G  E +   P  D +         K + F
Sbjct: 359 PTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGY---PCQDGMCGYCHHRRIKISNF 415

Query: 408 QPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVV 467
              L+       +D      AL PE++E + S+ YIA  ++ Q +   +++DW++VAMV+
Sbjct: 416 SANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVI 475

Query: 468 DRLFLWTFIIFTSVGTLVIFL 488
           DR+FLW F +   +GT  +FL
Sbjct: 476 DRIFLWVFTLVCILGTAGLFL 496


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score =  329 bits (844), Expect = 3e-90
 Identities = 179/491 (36%), Positives = 273/491 (55%), Gaps = 47/491 (9%)

Query: 16  PLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMST 75
           P   G  G   E RL  KLFS Y+  +RP   V D V V   + + QL +++E ++ M T
Sbjct: 23  PFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMET 82

Query: 76  KVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSS 135
            ++L   W DY+L WDP E+DGI++LR+ A+ +W PD+VL NN  G+F V      ++  
Sbjct: 83  NLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKY 142

Query: 136 DGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEI 195
           +G + W PP I++SSC + +T+FPFD QNC++ F S++YD +E+ L   +G         
Sbjct: 143 NGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI-IGS-------- 193

Query: 196 HIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGR--------EGQRQEVIFYLIIRRKPLF 247
            +    F EN +WEII           D  G +        E    ++ +   IRR P+F
Sbjct: 194 KVDMNDFWENSEWEII-----------DASGYKHDIKYNCCEEIYTDITYSFYIRRLPMF 242

Query: 248 YLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPI 307
           Y +N+I PC+ I+ L + VFYLP D GEK+ L I  LL+LTVFLL++ + +P TSL VP+
Sbjct: 243 YTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPL 302

Query: 308 IIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPE- 366
           + +YL+FTM+ VT S++++V VLN+H+R+P TH MP WV+ +F+  LP  L ++ P  + 
Sbjct: 303 VGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKT 362

Query: 367 ---------RDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLR 417
                    R L   P        G  R   E F     ++    K       LS   L+
Sbjct: 363 RGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSK-----RRLSHQPLQ 417

Query: 418 RFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFII 477
             ++    +    PE+ +V++S+ +IA  ++   +   +++DW++VAMVVDR+FLW FII
Sbjct: 418 WVVENSEHS----PEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFII 473

Query: 478 FTSVGTLVIFL 488
               GT  +FL
Sbjct: 474 VCVFGTAGLFL 484


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score =  317 bits (811), Expect = 2e-86
 Identities = 164/376 (43%), Positives = 235/376 (62%), Gaps = 29/376 (7%)

Query: 1   MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLIL 60
           + P  LL+  G L A      R + AE RL +KLFSGY+   RP   + D V V  GL +
Sbjct: 12  LPPLLLLLGTGLLRASSHVETR-AHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSI 70

Query: 61  AQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNND 120
           AQLI ++EK++ M+T V++  EW DY+L WDPA+++ + S+RI +E +W PD+VL NN D
Sbjct: 71  AQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNAD 130

Query: 121 GNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS 180
           G+F V       +  DG V+W PP IY+SSCSI VT+FPFD QNCTM F S++YD +++ 
Sbjct: 131 GDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKID 190

Query: 181 LQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQE------ 234
           L          +    + +  F E+G+W I+           D  G    ++ E      
Sbjct: 191 LV---------NMHSRVDQLDFWESGEWVIV-----------DAVGTYNTRKYECCAEIY 230

Query: 235 --VIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLL 292
             + +  +IRR PLFY +N+I PC+LI+ L + VFYLP + GEK+ L I  LL+LTVFLL
Sbjct: 231 PDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLL 290

Query: 293 LLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIH 352
           L+ + +P TSL +P+I +YL+FTM+ VT S++++V VLN+HHRSP TH MP WVR++F+ 
Sbjct: 291 LITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLD 350

Query: 353 KLPLYLRLKRPKPERD 368
            +P  L +KRP   +D
Sbjct: 351 IVPRLLLMKRPSVVKD 366



 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 40/122 (32%), Positives = 59/122 (48%), Gaps = 9/122 (7%)

Query: 374 PHCSSPGSGWGRGTDEYFIRKPPSDFLFP-------KPNRFQPELSAPDLRRFIDGPNRA 426
           P      +G     + +    PP D   P       +P+   P  SA    R    P   
Sbjct: 500 PEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSP--SATVKTRSTKAPPPH 557

Query: 427 VALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVI 486
           + L P L   V  + YIA  L+ ++   ++KEDW++VAMV+DR+FLW FII   +GT+ +
Sbjct: 558 LPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGL 617

Query: 487 FL 488
           FL
Sbjct: 618 FL 619


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score =  316 bits (809), Expect = 4e-86
 Identities = 183/505 (36%), Positives = 283/505 (56%), Gaps = 71/505 (14%)

Query: 1   MTPGALLMLLGALGAPLAP--GVRG-SEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVG 57
           M P  +L+L+  LG P +   G    +E E  L   LF GY   VRP     D ++V  G
Sbjct: 1   MLPDFMLVLI-VLGIPSSATTGFNSIAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFG 59

Query: 58  LILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLN 117
           L ++QL+ ++EK++ M+T V+L  EWTD++L W+P ++ GI S+++ +ES+WLPD+VL  
Sbjct: 60  LKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFE 119

Query: 118 NNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSS 177
           N DG F+ +L   V+V S+G+V W PP  Y+SSC++ VT+FPFD QNC+M F S++YD +
Sbjct: 120 NADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGT 179

Query: 178 EVSLQTGLGPDGQGHQEIHIHEGT----FIENGQWEIIHKPSRLIQPPGDPRGGREGQRQ 233
            V L             I I+E      F +NG+WEI++              G +G R+
Sbjct: 180 MVDL-------------ILINENVDRKDFFDNGEWEILNAK------------GMKGNRR 214

Query: 234 E-------VIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLT 286
           +       + +  ++RR PLFY + +I PC+ ++ L + VFYLP D GEK+ LS   L++
Sbjct: 215 DGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVS 274

Query: 287 LTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHT-HQMPLW 345
           LTVFLL++ + +P +S  +P+I +YL+F M+ VT S+I++V V+N+HHRS  T H M  W
Sbjct: 275 LTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPW 334

Query: 346 VRQIFIHKLPLYLRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPN 405
           V+++F+ KLP  L +K    +R   PE         G                       
Sbjct: 335 VKRLFLQKLPKLLCMK-DHVDRYSSPEKEESQPVVKG----------------------- 370

Query: 406 RFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAM 465
                L     ++  DG    VA    L +   SI YI+R ++++     + +DW+FVA 
Sbjct: 371 ---KVLEKKKQKQLSDGEKVLVAF---LEKAADSIRYISRHVKKEHFISQVVQDWKFVAQ 424

Query: 466 VVDRLFLWTFIIFTSVGTLVIFLDA 490
           V+DR+FLW F+I +  G+++IF  A
Sbjct: 425 VLDRIFLWLFLIVSVTGSVLIFTPA 449


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score =  313 bits (802), Expect = 2e-85
 Identities = 179/493 (36%), Positives = 271/493 (54%), Gaps = 53/493 (10%)

Query: 1   MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLIL 60
           M P  LL+L     A L   V GSE E RL  KLF  Y S VRP  +    V V+VGL L
Sbjct: 1   MEPWPLLLLFSLCSAGL---VLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQL 57

Query: 61  AQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNND 120
            QLI+++E ++ ++T V L  +W DY L W+P ++ G+  + I +E +W PD+VL NN D
Sbjct: 58  IQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNAD 117

Query: 121 GNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVS 180
           G+F +     V++   G + W PP I++S C I VT+FPFD QNC+M   +++YD S V+
Sbjct: 118 GDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVA 177

Query: 181 LQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLI 240
           +           +        F+E+G+W I  K SR  +         +    ++ ++ +
Sbjct: 178 INP---------ESDQPDLSNFMESGEWVI--KESRGWKHSVTYSCCPDTPYLDITYHFV 226

Query: 241 IRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPE 300
           ++R PL+++VNVI PC+L + L   VFYLP D+GEKM LSI  LL+LTVFLL++ + +P 
Sbjct: 227 MQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPS 286

Query: 301 TSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLP---LY 357
           TS +VP+I KY++FTMV V  S+I++V+V+N HHRSP TH MP WVR++FI  +P    +
Sbjct: 287 TSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFF 346

Query: 358 LRLKRP---KPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAP 414
             +KRP   K ++ +  E    S      G          PP  F  P            
Sbjct: 347 STMKRPSREKQDKKIFTEDIDISDISGKPG---------PPPMGFHSP------------ 385

Query: 415 DLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWT 474
                       +   PE++  +  I YIA  ++  ++ +    +W++VAMV+D + L  
Sbjct: 386 ------------LIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGV 433

Query: 475 FIIFTSVGTLVIF 487
           F++   +GTL +F
Sbjct: 434 FMLVCIIGTLAVF 446


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score =  300 bits (768), Expect = 2e-81
 Identities = 183/519 (35%), Positives = 274/519 (52%), Gaps = 80/519 (15%)

Query: 1   MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLIL 60
           M P  LL+L     A L   V GSE E RL  KLF  Y S VRP  +    V V+VGL L
Sbjct: 1   MEPWPLLLLFSLCSAGL---VLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQL 57

Query: 61  AQLISLNEKDEEMSTKVYL------DL-------------------EWTDYRLSWDPAEH 95
            QLI+++E ++ ++T V L      DL                   +W DY L W+P ++
Sbjct: 58  IQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDY 117

Query: 96  DGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQV 155
            G+  + I +E +W PD+VL NN DG+F +     V++   G + W PP I++S C I V
Sbjct: 118 GGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIV 177

Query: 156 TYFPFDWQNCTMVFSSYSYDSSEVSLQTGLG-PDGQGHQEIHIHEGTFIENGQWEIIHKP 214
           T+FPFD QNC+M   +++YD S V++      PD             F+E+G+W I  K 
Sbjct: 178 THFPFDEQNCSMKLGTWTYDGSVVAINPESDQPD----------LSNFMESGEWVI--KE 225

Query: 215 SRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAG 274
           SR  +         +    ++ ++ +++R PL+++VNVI PC+L + L   VFYLP D+G
Sbjct: 226 SRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG 285

Query: 275 EKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHH 334
           EKM LSI  LL+LTVFLL++ + +P TS +VP+I KY++FTMV V  S+I++V+V+N HH
Sbjct: 286 EKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH 345

Query: 335 RSPHTHQMPLWVRQIFIHKLP---LYLRLKRP---KPERDLMPEPPHCSSPGSGWGRGTD 388
           RSP TH MP WVR++FI  +P    +  +KRP   K ++ +  E    S      G    
Sbjct: 346 RSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPG---- 401

Query: 389 EYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQ 448
                 PP  F  P                        +   PE++  +  I YIA  ++
Sbjct: 402 -----PPPMGFHSP------------------------LIKHPEVKSAIEGIKYIAETMK 432

Query: 449 EQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIF 487
             ++ +    +W++VAMV+D + L  F++   +GTL +F
Sbjct: 433 SDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVF 471


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score =  300 bits (767), Expect = 3e-81
 Identities = 164/474 (34%), Positives = 262/474 (55%), Gaps = 76/474 (16%)

Query: 27  EGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDY 86
           E  L + LF  Y+  VRP   + D++++  GL ++QL+ ++EK++ M+T V+L  EW D 
Sbjct: 47  EDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDV 106

Query: 87  RLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGI 146
           +L W+P ++ GI  +R+ ++SVW PD+VL +N DG F+       V+  +G+V W PP  
Sbjct: 107 KLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFE-GTSTKTVIRYNGTVTWTPPAN 165

Query: 147 YRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENG 206
           Y+SSC+I VT+FPFD QNC+M F S++YD S+V +           ++  + +  F +NG
Sbjct: 166 YKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL---------EDQDVDKRDFFDNG 216

Query: 207 QWEIIHKPSRLIQPPGDPRGGREGQRQE-------VIFYLIIRRKPLFYLVNVIAPCILI 259
           +WEI+               G +G R +       V +  +I+R PLFY + +I PCI +
Sbjct: 217 EWEIVSAT------------GSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGL 264

Query: 260 TLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLV 319
           + L + VFYLP + GEK+ L    L++LTVFLL++ + +P +S  +P+I +YL+FTM+ V
Sbjct: 265 SFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFV 324

Query: 320 TFSVILSVVVLNLHHRSPHTHQ-MPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCSS 378
           T S++++V  +N+HHRS  TH  M   VR+IF+H LP  L ++                 
Sbjct: 325 TLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMR----------------- 367

Query: 379 PGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVS 438
                    D YF +K  ++      +   P+ S   L   +D                 
Sbjct: 368 ------SHVDRYFTQKEETE------SGSGPKSSRNTLEAALD----------------- 398

Query: 439 SISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATY 492
           SI YI R + ++ D   + EDW+F+A V+DR+FLWTF+  + VG+L +F+   Y
Sbjct: 399 SIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIY 452


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score =  270 bits (691), Expect = 2e-72
 Identities = 167/518 (32%), Positives = 271/518 (52%), Gaps = 60/518 (11%)

Query: 2   TPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILA 61
           +PG + +   AL A L       E + +L ++L   Y+   RP       + V   L L 
Sbjct: 4   SPGGVWL---ALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLL 60

Query: 62  QLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDG 121
           Q++ ++EK++ ++T ++L + WTD+ L W+ +E+ G+ ++R     +W PD++L N+ D 
Sbjct: 61  QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADE 120

Query: 122 NFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSL 181
            FD     +V+V+S G  ++ PPGI++SSC I V +FPFD Q+C + F S+SY    + L
Sbjct: 121 RFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDL 180

Query: 182 QTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPS----RLIQPPGDPRGGREGQRQEVIF 237
           Q          QE  I    +I NG+W+++  P     R  +   +P         +V F
Sbjct: 181 QM---------QEADI--SGYIPNGEWDLVGIPGKRSERFYECCKEPY-------PDVTF 222

Query: 238 YLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADK 297
            + +RR+ L+Y +N++ PC+LI+ LA+ VF LP D+GEK+ L I  LL+LTVF+LL+A+ 
Sbjct: 223 TVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEI 282

Query: 298 VPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLY 357
           +P TS SVP+I +Y   TM++V  SV+++V+VL  HH  P   +MP W R I ++    +
Sbjct: 283 MPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWF 342

Query: 358 LRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPP----SDFLF------------ 401
           LR+KRP  ++      P C          + E     PP     + L+            
Sbjct: 343 LRMKRPGEDK----VRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCV 398

Query: 402 PKPNRFQPELSAPDLRRFIDGPNRAVALL---------PELREVVSSISYIARQLQEQED 452
           P P+      S     R    P     LL         P+L +++  + YIA + + Q++
Sbjct: 399 PTPD------SGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDE 452

Query: 453 HDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDA 490
            +A+  +W+F A VVDRL L  F +FT + T+ I + A
Sbjct: 453 SEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 490


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score =  242 bits (618), Expect = 5e-64
 Identities = 153/473 (32%), Positives = 239/473 (50%), Gaps = 56/473 (11%)

Query: 26  AEGRLREKLF----SGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDL 81
           AEGRL  KLF    + Y S++RP  +    + V++ + L+Q+I ++E+++ ++  +++  
Sbjct: 25  AEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQ 84

Query: 82  EWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRW 141
           EWTD  L WDP  + G+D++RI +  VW PD+VL N  D     +   +VV+  DG+VRW
Sbjct: 85  EWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRW 144

Query: 142 QPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGT 201
             P I RSSC + V  FPFD Q+C + F S+++   ++ ++    P G            
Sbjct: 145 DAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVR----PRGAA-----ASLAD 195

Query: 202 FIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITL 261
           F+EN +W ++  P+R         G       +V F L++RR+   Y+ N++ PC+LI+L
Sbjct: 196 FVENVEWRVLGMPARRRVL---TYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISL 252

Query: 262 LAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTF 321
           LA   F+LP D+GEK+ L +  LL LTVF LLLA+ +P    SVP+I KY M TM +VTF
Sbjct: 253 LAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAE-SVPLIGKYYMATMTMVTF 311

Query: 322 SVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCS---- 377
           S  L+++++NLH+  P    +P W R + +  L   L + R + E      PP  S    
Sbjct: 312 STALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCV-RERGEPCGQSRPPELSPSPQ 370

Query: 378 SPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVV 437
           SP  G G          PP+                        GP      L     ++
Sbjct: 371 SPEGGAG----------PPA------------------------GPCHEPRCLCRQEALL 396

Query: 438 SSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDA 490
             ++ IA   +         EDW+ +A V+DR FL  F     V +L++ + A
Sbjct: 397 HHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQA 449


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score =  234 bits (596), Expect = 2e-61
 Identities = 146/486 (30%), Positives = 250/486 (51%), Gaps = 37/486 (7%)

Query: 18  APGVRGSE-AEGRLREKLFSG----YDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEE 72
           A  +R +E A+G+  +KLF+     Y +++RP  +    + V++ + L+Q+  ++E+++ 
Sbjct: 17  ASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQI 76

Query: 73  MSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVV 132
           ++  +++   W D  L+WD  ++DG+DS+RI ++ VW PD+VL N  D      ++ +VV
Sbjct: 77  LTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVV 136

Query: 133 VSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGH 192
           +  DG + W  P I +SSC + VTYFPFD Q C + F S++Y+ ++V +   L       
Sbjct: 137 LRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDL-- 194

Query: 193 QEIHIHEGTFIENGQWEIIHKPS--RLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLV 250
                    FIE+ +WE+   P+   +I       G       +V F L+++R+  FY+V
Sbjct: 195 -------SDFIEDVEWEVHGMPAVKNVIS-----YGCCSEPYPDVTFTLLLKRRSSFYIV 242

Query: 251 NVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIK 310
           N++ PC+LI+ LA   FYLP  +GEK+ L +  LL +TVF L++A+ +P  S +VP+I K
Sbjct: 243 NLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMP-ASENVPLIGK 301

Query: 311 YLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLM 370
           Y + TM L+T S  L+++V+N+H        +P W R + +  +   L          + 
Sbjct: 302 YYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVL---------FVY 352

Query: 371 PEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFID------GPN 424
                C SP     R        K P   L    N+        + R   D       P 
Sbjct: 353 DVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQ 412

Query: 425 RAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTL 484
            A +   + + +  +I YIA+ L++ +  ++   +W+ VA V+DR F+W F I   V T+
Sbjct: 413 EAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTI 472

Query: 485 VIFLDA 490
           +I   A
Sbjct: 473 LIIARA 478


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score =  208 bits (530), Expect = 8e-54
 Identities = 134/400 (33%), Positives = 207/400 (51%), Gaps = 57/400 (14%)

Query: 120 DGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEV 179
           D  FD     +V+V+S G  ++ PPGI++SSC I V +FPFD Q+C + F S+SY    +
Sbjct: 29  DERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSL 88

Query: 180 SLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPS----RLIQPPGDPRGGREGQRQEV 235
            LQ          QE  I    +I NG+W+++  P     R  +   +P         +V
Sbjct: 89  DLQM---------QEADI--SGYIPNGEWDLVGIPGKRSERFYECCKEPY-------PDV 130

Query: 236 IFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLA 295
            F + +RR+ L+Y +N++ PC+LI+ LA+ VF LP D+GEK+ L I  LL+LTVF+LL+A
Sbjct: 131 TFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVA 190

Query: 296 DKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLP 355
           + +P TS SVP+I +Y   TM++V  SV+++V+VL  HH  P   +MP W R I ++   
Sbjct: 191 EIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCA 250

Query: 356 LYLRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPP----SDFLF---------- 401
            +LR+KRP  ++      P C          + E     PP     + L+          
Sbjct: 251 WFLRMKRPGEDK----VRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVH 306

Query: 402 --PKPNRFQPELSAPDLRRFIDGPNRAVALL---------PELREVVSSISYIARQLQEQ 450
             P P+      S     R    P     LL         P+L +++  + YIA + + Q
Sbjct: 307 CVPTPD------SGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQ 360

Query: 451 EDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDA 490
           ++ +A+  +W+F A VVDRL L  F +FT + T+ I + A
Sbjct: 361 DESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 400


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  186 bits (473), Expect = 3e-47
 Identities = 117/455 (25%), Positives = 223/455 (49%), Gaps = 37/455 (8%)

Query: 29  RLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRL 88
           RL + L + Y   VRP R+      VS+ +I+  +++++EK++ ++T ++    WTD  L
Sbjct: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101

Query: 89  SWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYR 148
            W+P + D I  L I  +S+W+PD+++    D      +   V +   G V+   P    
Sbjct: 102 QWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPY-VYIRHQGEVQNYKPLQVV 160

Query: 149 SSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQW 208
           ++CS+ +  FPFD QNC++ F+S+ +   ++++     P+     ++      F+  G+W
Sbjct: 161 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPE-----KVKSDRSVFMNQGEW 215

Query: 209 EIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFY 268
           E++       +   +          E+ FY++IRR+PLFY+V+++ P I + ++ I  FY
Sbjct: 216 ELLGVLPYFREFSMES----SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFY 271

Query: 269 LPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVV 328
           LPP++GE++   I  LL  +VFL++++D +P T++  P+I  Y +  M L+  S+  ++ 
Sbjct: 272 LPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIF 331

Query: 329 VLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLK------RPKPERDLMPEPPHCSSPGSG 382
           ++ L H+      +P W+R + + ++   L L+      RP P      +   CS+ G+ 
Sbjct: 332 IVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRP-PATSQATKTDDCSAMGNH 390

Query: 383 WGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISY 442
                      K P D   P P   +  L+                LL EL       S 
Sbjct: 391 CSHMGGPQDFEKSPRDRCSPPPPPREASLA-------------VCGLLQEL-------SS 430

Query: 443 IARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFII 477
           I + L+++++   +  DW  V  V+D+L    +++
Sbjct: 431 IRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 465


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  186 bits (473), Expect = 3e-47
 Identities = 117/455 (25%), Positives = 223/455 (49%), Gaps = 37/455 (8%)

Query: 29  RLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRL 88
           RL + L + Y   VRP R+      VS+ +I+  +++++EK++ ++T ++    WTD  L
Sbjct: 21  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 80

Query: 89  SWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYR 148
            W+P + D I  L I  +S+W+PD+++    D      +   V +   G V+   P    
Sbjct: 81  QWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPY-VYIRHQGEVQNYKPLQVV 139

Query: 149 SSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQW 208
           ++CS+ +  FPFD QNC++ F+S+ +   ++++     P+     ++      F+  G+W
Sbjct: 140 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPE-----KVKSDRSVFMNQGEW 194

Query: 209 EIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFY 268
           E++       +   +          E+ FY++IRR+PLFY+V+++ P I + ++ I  FY
Sbjct: 195 ELLGVLPYFREFSMES----SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFY 250

Query: 269 LPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVV 328
           LPP++GE++   I  LL  +VFL++++D +P T++  P+I  Y +  M L+  S+  ++ 
Sbjct: 251 LPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIF 310

Query: 329 VLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLK------RPKPERDLMPEPPHCSSPGSG 382
           ++ L H+      +P W+R + + ++   L L+      RP P      +   CS+ G+ 
Sbjct: 311 IVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRP-PATSQATKTDDCSAMGNH 369

Query: 383 WGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISY 442
                      K P D   P P   +  L+                LL EL       S 
Sbjct: 370 CSHMGGPQDFEKSPRDRCSPPPPPREASLA-------------VCGLLQEL-------SS 409

Query: 443 IARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFII 477
           I + L+++++   +  DW  V  V+D+L    +++
Sbjct: 410 IRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLL 444


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score =  172 bits (437), Expect = 5e-43
 Identities = 118/487 (24%), Positives = 224/487 (45%), Gaps = 69/487 (14%)

Query: 29  RLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRL 88
           RL + L + Y   VRP R+      VS+ +I+  +++++EK++ ++T ++    WTD  L
Sbjct: 42  RLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFL 101

Query: 89  SWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYR 148
            W+P + D I  L I  +S+W+PD+++    D      +   V +   G V+   P    
Sbjct: 102 QWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPY-VYIRHQGEVQNYKPLQVV 160

Query: 149 SSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQW 208
           ++CS+ +  FPFD QNC++ F+S+ +   ++++     P+     ++      F+  G+W
Sbjct: 161 TACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPE-----KVKSDRSVFMNQGEW 215

Query: 209 EIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFY 268
           E++       +   +          E+ FY++IRR+PLFY+V+++ P I + ++ I  FY
Sbjct: 216 ELLGVLPYFREFSMES----SNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFY 271

Query: 269 LPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIK------------------ 310
           LPP++GE++   I  LL  +VFL++++D +P T++  P+I K                  
Sbjct: 272 LPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGKAPPGSRAQSGEKPAPSHL 331

Query: 311 --------------YLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPL 356
                         Y +  M L+  S+  ++ ++ L H+      +P W+R + + ++  
Sbjct: 332 LHVSLASALGCTGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAW 391

Query: 357 YLRLK------RPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPE 410
            L L+      RP P      +   CS+ G+            K P D   P P   +  
Sbjct: 392 LLCLREQSTSQRP-PATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREAS 450

Query: 411 LSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRL 470
           L+                LL EL       S I + L+++++   +  DW  V  V+D+L
Sbjct: 451 LA-------------VCGLLQEL-------SSIRQFLEKRDEIREVARDWLRVGSVLDKL 490

Query: 471 FLWTFII 477
               +++
Sbjct: 491 LFHIYLL 497


>gi|23312390 CHRNA7-FAM7A fusion isoform 2 [Homo sapiens]
          Length = 321

 Score =  159 bits (402), Expect = 6e-39
 Identities = 103/318 (32%), Positives = 164/318 (51%), Gaps = 46/318 (14%)

Query: 202 FIENGQWEIIHKPS----RLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCI 257
           +I NG+W+++  P     R  +   +P         +V F + +RR+ L+Y +N++ PC+
Sbjct: 9   YIPNGEWDLVGIPGKRSERFYECCKEPY-------PDVTFTVTMRRRTLYYGLNLLIPCV 61

Query: 258 LITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMV 317
           LI+ LA+ VF LP D+GEK+ L I  LL+LTVF+LL+A+ +P TS SVP+I +Y   TM+
Sbjct: 62  LISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMI 121

Query: 318 LVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCS 377
           +V  SV+++V+VL  HH  P   +MP W R I ++    +LR+KRP  ++      P C 
Sbjct: 122 IVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDK----VRPACQ 177

Query: 378 SPGSGWGRGTDEYFIRKPP----SDFLF------------PKPNRFQPELSAPDLRRFID 421
                    + E     PP     + L+            P P+      S     R   
Sbjct: 178 HKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPD------SGVVCGRMAC 231

Query: 422 GPNRAVALL---------PELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFL 472
            P     LL         P+L +++  + YIA + + Q++ +A+  +W+F A VVDRL L
Sbjct: 232 SPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCL 291

Query: 473 WTFIIFTSVGTLVIFLDA 490
             F +FT + T+ I + A
Sbjct: 292 MAFSVFTIICTIGILMSA 309


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  148 bits (374), Expect = 1e-35
 Identities = 94/378 (24%), Positives = 183/378 (48%), Gaps = 35/378 (9%)

Query: 43  RPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLR 102
           RP   +    +V++   ++ ++ +NE+   +S+ ++L++ W +  +SW+P E +GI  + 
Sbjct: 70  RPVTNISVPTQVNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMS 129

Query: 103 ITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDW 162
           + A+++WLPD+ ++   D +      ++  VS++G +R++ P    S C++ + YFPFD 
Sbjct: 130 MAAKNLWLPDIFIIELMDVD-KTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQ 188

Query: 163 QNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPG 222
           QNCT+ FSS+ Y    + L      + +  +           +G+WE++       +   
Sbjct: 189 QNCTLTFSSFLYTVDSMLLDM----EKEVWEITDASRNILQTHGEWELLGLSKATAKLS- 243

Query: 223 DPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIF 282
             RGG      +++FY+ IRR+P  Y++N++ P   +  +    FYLP  +G ++   I 
Sbjct: 244 --RGGN--LYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKIT 299

Query: 283 ALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLN-LHHRSPHTHQ 341
            LL   VFLL+++D +P +    P+I  Y    + L+  S++ ++ + + LH  +     
Sbjct: 300 LLLGYNVFLLMMSDLLPTS--GTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPP 357

Query: 342 MPLWVRQIFIH--------------------KLPLYL-RLKRPKPERDLMPEPPHCS-SP 379
           +P W+  + +H                      P +L  +K P+     MP P     + 
Sbjct: 358 LPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTG 417

Query: 380 GSGWGRGTDEYFIRKPPS 397
           GS W R   E+  +K  S
Sbjct: 418 GSEWTRAQREHEAQKQHS 435


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  144 bits (363), Expect = 2e-34
 Identities = 81/311 (26%), Positives = 155/311 (49%), Gaps = 13/311 (4%)

Query: 43  RPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLR 102
           RP        RV++   L+ ++ ++ + + +++ +++DL W +  ++W+P E  GI+ L 
Sbjct: 55  RPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLT 114

Query: 103 ITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDW 162
           + AE++WLPD+ ++ + D +      ++  +SS+G +++  P    S C++ + YFPFD 
Sbjct: 115 VLAENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQ 173

Query: 163 QNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPG 222
           QNCT  FSS+ Y    + L    G D +  +            G+WE++      I    
Sbjct: 174 QNCTFTFSSFLYTVDSMLL----GMDKEVWEITDTSRKVIQTQGEWELLG-----INKAT 224

Query: 223 DPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIF 282
                      +++FY+ IRR+P  Y++N++ P   +  +    FYLP ++  +    I 
Sbjct: 225 PKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKIT 284

Query: 283 ALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSV-VVLNLHHRSPHTHQ 341
            LL   VFLL++ D +P +    P+I  Y    + L+  S++ +V +   LH  +     
Sbjct: 285 LLLGYNVFLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPP 342

Query: 342 MPLWVRQIFIH 352
           MP W+  + +H
Sbjct: 343 MPRWLHSLLLH 353


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score =  124 bits (311), Expect = 2e-28
 Identities = 78/308 (25%), Positives = 151/308 (49%), Gaps = 17/308 (5%)

Query: 30  LREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLS 89
           L ++L   Y   VRP         V + L +  ++ ++ +++ + T V+    W D  LS
Sbjct: 35  LSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLS 94

Query: 90  WDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVV-VSSDGSVRWQPPGIYR 148
           W+ +  D I  + +   ++W PD+++  N   + +   D+  V V+S G++    P    
Sbjct: 95  WNSSMFDEIREISLPLSAIWAPDIII--NEFVDIERYPDLPYVYVNSSGTIENYKPIQVV 152

Query: 149 SSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQW 208
           S+CS++   FPFD QNC++ F S  +   +V L     P+   H +       F+ + +W
Sbjct: 153 SACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDK-----KAFLNDSEW 207

Query: 209 EIIHKPSR--LIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFV 266
           E++   S   ++Q          G   ++ F +++RR PL Y+V+++ P I + L+ +  
Sbjct: 208 ELLSVSSTYSILQSSA-------GGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGS 260

Query: 267 FYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILS 326
           FYLPP+   ++      L+  TVF + ++++VP +  S P+I  +    M  +  S+  S
Sbjct: 261 FYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKS 320

Query: 327 VVVLNLHH 334
           +V++   H
Sbjct: 321 IVLVKFLH 328



 Score = 30.8 bits (68), Expect = 3.0
 Identities = 14/54 (25%), Positives = 27/54 (50%)

Query: 433 LREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVI 486
           L+EV S +  I+  LQ Q+  D  + +W  +    DRL   +++    + T+ +
Sbjct: 378 LKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITL 431


>gi|4504023 glycine receptor, beta [Homo sapiens]
          Length = 497

 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 84/311 (27%), Positives = 138/311 (44%), Gaps = 23/311 (7%)

Query: 24  SEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEW 83
           + +   +  +L   YD  +RP  + G  V V V + +    S+ E   +    ++L  +W
Sbjct: 53  ANSTSNILNRLLVSYDPRIRPNFK-GIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKW 111

Query: 84  TDYRLSWDPAEHDGIDSLRITA---ESVWLPDVVLLNNNDGNF-DVALD-ISVVVSSDGS 138
            D RL   P++  G D+L +     + +W PD+   N    NF DV  + I + +  DG 
Sbjct: 112 NDPRLKL-PSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGD 170

Query: 139 VRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIH 198
           V          SC + +T FP D Q C M   S+ Y + ++      G   Q  +     
Sbjct: 171 VLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEK----- 225

Query: 199 EGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCIL 258
               I   Q++I  +           +G       EVIF L  RR+  FY++ V AP +L
Sbjct: 226 ----IALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTL--RRQVGFYMMGVYAPTLL 279

Query: 259 ITLLAIFVFYLPPDA-GEKMGLSIFALLTLTVFLLLLADKVPETS----LSVPIIIKYLM 313
           I +L+   F++ PDA   ++ L IF++L+L      LA ++P+ S    L V +I   L 
Sbjct: 280 IVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLF 339

Query: 314 FTMVLVTFSVI 324
               LV ++V+
Sbjct: 340 GFASLVEYAVV 350


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 87/343 (25%), Positives = 144/343 (41%), Gaps = 37/343 (10%)

Query: 36  SGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEH 95
           SGYD+ +RP  + G  V V+  + +    S+ E   +    ++L  +W D RL++     
Sbjct: 56  SGYDARIRPNFK-GPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPD 114

Query: 96  DGIDSLRITAESVWLPDVVLLNNNDGNF-DVALDISVV-VSSDGSVRWQPPGIYRSSCSI 153
           D +D      +S+W PD+   N    NF DV  D  ++ +S +G V +        SC +
Sbjct: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPM 174

Query: 154 QVTYFPFDWQNCTMVFSSYSYDSSEVSLQ-TGLGPDGQGHQEIHIHEGTFIENGQWEIIH 212
            +  FP D Q CTM   S+ Y  +++  +    GP       + + EG  +     + I 
Sbjct: 175 DLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGP-------VQVAEGLTLP----QFIL 223

Query: 213 KPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPD 272
           K  + +          +    EV F+L   R+  +YL+ +  P +LI +L+   F++  D
Sbjct: 224 KEEKELGYCTKHYNTGKFTCIEVKFHL--ERQMGYYLIQMYIPSLLIVILSWVSFWINMD 281

Query: 273 AG-EKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLN 331
           A   ++ L I  +LT+T         +P+ S    I I   M   +L  F+ +L    +N
Sbjct: 282 AAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDI--WMAVCLLFVFAALLEYAAVN 339

Query: 332 LHHRSPHTHQMPLWVRQIFIHK--LPLYLRLKRPKPERDLMPE 372
              R                HK  L L  R KR   E D+  E
Sbjct: 340 FVSRQ---------------HKEFLRLRRRQKRQNKEEDVTRE 367


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 87/343 (25%), Positives = 144/343 (41%), Gaps = 37/343 (10%)

Query: 36  SGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEH 95
           SGYD+ +RP  + G  V V+  + +    S+ E   +    ++L  +W D RL++     
Sbjct: 56  SGYDARIRPNFK-GPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPD 114

Query: 96  DGIDSLRITAESVWLPDVVLLNNNDGNF-DVALDISVV-VSSDGSVRWQPPGIYRSSCSI 153
           D +D      +S+W PD+   N    NF DV  D  ++ +S +G V +        SC +
Sbjct: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPM 174

Query: 154 QVTYFPFDWQNCTMVFSSYSYDSSEVSLQ-TGLGPDGQGHQEIHIHEGTFIENGQWEIIH 212
            +  FP D Q CTM   S+ Y  +++  +    GP       + + EG  +     + I 
Sbjct: 175 DLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGP-------VQVAEGLTLP----QFIL 223

Query: 213 KPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPD 272
           K  + +          +    EV F+L   R+  +YL+ +  P +LI +L+   F++  D
Sbjct: 224 KEEKELGYCTKHYNTGKFTCIEVKFHL--ERQMGYYLIQMYIPSLLIVILSWVSFWINMD 281

Query: 273 AG-EKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLN 331
           A   ++ L I  +LT+T         +P+ S    I I   M   +L  F+ +L    +N
Sbjct: 282 AAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDI--WMAVCLLFVFAALLEYAAVN 339

Query: 332 LHHRSPHTHQMPLWVRQIFIHK--LPLYLRLKRPKPERDLMPE 372
              R                HK  L L  R KR   E D+  E
Sbjct: 340 FVSRQ---------------HKEFLRLRRRQKRQNKEEDVTRE 367


>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
          Length = 452

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 87/343 (25%), Positives = 144/343 (41%), Gaps = 37/343 (10%)

Query: 36  SGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEH 95
           SGYD+ +RP  + G  V V+  + +    S+ E   +    ++L  +W D RL++     
Sbjct: 56  SGYDARIRPNFK-GPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAYSEYPD 114

Query: 96  DGIDSLRITAESVWLPDVVLLNNNDGNF-DVALDISVV-VSSDGSVRWQPPGIYRSSCSI 153
           D +D      +S+W PD+   N    NF DV  D  ++ +S +G V +        SC +
Sbjct: 115 DSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPM 174

Query: 154 QVTYFPFDWQNCTMVFSSYSYDSSEVSLQ-TGLGPDGQGHQEIHIHEGTFIENGQWEIIH 212
            +  FP D Q CTM   S+ Y  +++  +    GP       + + EG  +     + I 
Sbjct: 175 DLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGP-------VQVAEGLTLP----QFIL 223

Query: 213 KPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPD 272
           K  + +          +    EV F+L   R+  +YL+ +  P +LI +L+   F++  D
Sbjct: 224 KEEKELGYCTKHYNTGKFTCIEVKFHL--ERQMGYYLIQMYIPSLLIVILSWVSFWINMD 281

Query: 273 AG-EKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLN 331
           A   ++ L I  +LT+T         +P+ S    I I   M   +L  F+ +L    +N
Sbjct: 282 AAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDI--WMAVCLLFVFAALLEYAAVN 339

Query: 332 LHHRSPHTHQMPLWVRQIFIHK--LPLYLRLKRPKPERDLMPE 372
              R                HK  L L  R KR   E D+  E
Sbjct: 340 FVSRQ---------------HKEFLRLRRRQKRQNKEEDVTRE 367


>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
          Length = 417

 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 94/421 (22%), Positives = 169/421 (40%), Gaps = 56/421 (13%)

Query: 3   PGALLMLLGALGAPLAPGVRGSE--AEGRLREKLF---SGYDSSVRPAREVGDRVRVSVG 57
           PG +L+ +      +  G +GS+  +     +KL    SGYD+ +RP  + G  V V+  
Sbjct: 18  PGQVLLRVALAKEEVKSGTKGSQPMSPSDFLDKLMGRTSGYDARIRPNFK-GPPVNVTCN 76

Query: 58  LILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLN 117
           + +    S+ +   +    V+L  +W D RLS+     D +D      +S+W PD+   N
Sbjct: 77  IFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYPDDSLDLDPSMLDSIWKPDLFFAN 136

Query: 118 NNDGNF-DVALDISVV-VSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYD 175
               NF +V  D  ++ +  +G+V +        SC + +  FP D Q CTM   S+ Y 
Sbjct: 137 EKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCLMDLKNFPMDIQTCTMQLESFGYT 196

Query: 176 SSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGD----PRGGREGQ 231
             ++  +       +    + + EG  +          P  +++   D     +    G+
Sbjct: 197 MKDLVFEW-----LEDAPAVQVAEGLTL----------PQFILRDEKDLGCCTKHYNTGK 241

Query: 232 RQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAG-EKMGLSIFALLTLTVF 290
              +     + R+  +YL+ +  P +LI +L+   F++  DA   ++GL I  +LT+T  
Sbjct: 242 FTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQ 301

Query: 291 LLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIF 350
                  +P+ S    I I   M   +L  F+ +L    +N   R               
Sbjct: 302 SSGSRASLPKVSYVKAIDI--WMAVCLLFVFAALLEYAAINFVSRQ-------------- 345

Query: 351 IHK--LPLYLRLKRPKPERDLMPEP---------PHCSSPGSGWGRGTDEYFIRKPPSDF 399
            HK  + L  R +R + E D++ E           HC     G        +  +PP+  
Sbjct: 346 -HKEFIRLRRRQRRQRLEEDIIQESRFYFRGYGLGHCLQARDGGPMEGSGIYSPQPPAPL 404

Query: 400 L 400
           L
Sbjct: 405 L 405


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.141    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,165,814
Number of Sequences: 37866
Number of extensions: 1122796
Number of successful extensions: 3271
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 3057
Number of HSP's gapped (non-prelim): 107
length of query: 501
length of database: 18,247,518
effective HSP length: 106
effective length of query: 395
effective length of database: 14,233,722
effective search space: 5622320190
effective search space used: 5622320190
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.