Search of human proteins with 40354212

Search of human proteins with 40354212

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2
[Homo sapiens]
         (437 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H...   876   0.0  
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [...   871   0.0  
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [...   871   0.0  
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho...   269   3e-72
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H...   142   8e-34
gi|219689123 pleckstrin homology domain containing, family A mem...    71   2e-12
gi|19923493 pleckstrin homology domain containing, family A memb...    71   2e-12
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ...    67   3e-11
gi|238859653 pleckstrin homology domain containing family A memb...    63   6e-10
gi|238859651 pleckstrin homology domain containing family A memb...    63   6e-10
gi|239047795 pleckstrin homology domain containing, family A mem...    54   2e-07
gi|115527076 src kinase associated phosphoprotein 1 isoform 2 [H...    54   2e-07
gi|115527074 src kinase associated phosphoprotein 1 isoform 1 [H...    54   2e-07
gi|154354979 myosin X [Homo sapiens]                                   53   6e-07
gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens]      50   4e-06
gi|126091130 Gab3 protein isoform 1 [Homo sapiens]                     49   1e-05
gi|18079323 Gab3 protein isoform 2 [Homo sapiens]                      48   2e-05
gi|18105042 GRB2-associated binding protein 2 isoform a [Homo sa...    45   1e-04
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]            45   2e-04
gi|20149626 pleckstrin homology domain containing, family O memb...    44   4e-04
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa...    43   5e-04
gi|83716021 GRB2-associated binding protein family, member 4 [Ho...    43   5e-04
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...    43   5e-04
gi|46195763 metastasis suppressor 1-like [Homo sapiens]                43   5e-04
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        43   5e-04
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           43   6e-04
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...    42   0.001
gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap...    42   0.001
gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo sap...    42   0.001
gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo sap...    42   0.001

>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
           sapiens]
          Length = 437

 Score =  876 bits (2263), Expect = 0.0
 Identities = 437/437 (100%), Positives = 437/437 (100%)

Query: 1   MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSN 60
           MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSN
Sbjct: 1   MTSYMAIDGSALVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLSN 60

Query: 61  KWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYF 120
           KWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYF
Sbjct: 61  KWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYF 120

Query: 121 AAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTA 180
           AAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTA
Sbjct: 121 AAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTA 180

Query: 181 QQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITF 240
           QQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITF
Sbjct: 181 QQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITF 240

Query: 241 AVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIM 300
           AVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIM
Sbjct: 241 AVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIM 300

Query: 301 DKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIR 360
           DKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIR
Sbjct: 301 DKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIR 360

Query: 361 TLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDT 420
           TLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDT
Sbjct: 361 TLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDDT 420

Query: 421 PQELKKSPSSPSVENSI 437
           PQELKKSPSSPSVENSI
Sbjct: 421 PQELKKSPSSPSVENSI 437


>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
           [Homo sapiens]
          Length = 438

 Score =  871 bits (2251), Expect = 0.0
 Identities = 437/438 (99%), Positives = 437/438 (99%), Gaps = 1/438 (0%)

Query: 1   MTSYMAIDGSAL-VPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS 59
           MTSYMAIDGSAL VPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS
Sbjct: 1   MTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS 60

Query: 60  NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY 119
           NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY
Sbjct: 61  NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY 120

Query: 120 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT 179
           FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT
Sbjct: 121 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT 180

Query: 180 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT 239
           AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT
Sbjct: 181 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT 240

Query: 240 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI 299
           FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI
Sbjct: 241 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI 300

Query: 300 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI 359
           MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI
Sbjct: 301 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI 360

Query: 360 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD 419
           RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD
Sbjct: 361 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD 420

Query: 420 TPQELKKSPSSPSVENSI 437
           TPQELKKSPSSPSVENSI
Sbjct: 421 TPQELKKSPSSPSVENSI 438


>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
           [Homo sapiens]
          Length = 438

 Score =  871 bits (2251), Expect = 0.0
 Identities = 437/438 (99%), Positives = 437/438 (99%), Gaps = 1/438 (0%)

Query: 1   MTSYMAIDGSAL-VPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS 59
           MTSYMAIDGSAL VPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS
Sbjct: 1   MTSYMAIDGSALQVPLRQKPRRKTQGFLTMSRRRISCKDLGHADCQGWLYKKKEKGSFLS 60

Query: 60  NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY 119
           NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY
Sbjct: 61  NKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFY 120

Query: 120 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT 179
           FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT
Sbjct: 121 FAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLT 180

Query: 180 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT 239
           AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT
Sbjct: 181 AQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPIT 240

Query: 240 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI 299
           FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI
Sbjct: 241 FAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKI 300

Query: 300 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI 359
           MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI
Sbjct: 301 MDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKI 360

Query: 360 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD 419
           RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD
Sbjct: 361 RTLNSTLKCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQQQRASPAPDDTDD 420

Query: 420 TPQELKKSPSSPSVENSI 437
           TPQELKKSPSSPSVENSI
Sbjct: 421 TPQELKKSPSSPSVENSI 438


>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
            sapiens]
          Length = 1034

 Score =  269 bits (688), Expect = 3e-72
 Identities = 163/460 (35%), Positives = 255/460 (55%), Gaps = 68/460 (14%)

Query: 15   LRQKPRRKTQGFLT-MSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS 73
            L+ K ++K +G +   S+RRISCKDLG  DC+GWL+KKK+  S+ S KWKK+W +LK +S
Sbjct: 543  LQHKSKKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDAS 602

Query: 74   LYWYSNQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLN 133
            LYWY N+  EKA+GF++LP+F ++RASEC+KK+AFK  HP+IK+FYFAAE++ +MN WLN
Sbjct: 603  LYWYINEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLN 662

Query: 134  K---LGSAVIHQESTTKDEECYSESEQEDPEIAA----ETPPPPH--------------- 171
            +   L +    +E   ++++ +SES++E+ +  +    ++PPPP+               
Sbjct: 663  RINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPY 722

Query: 172  ------------ASQTQSLTAQ-----QASSSSPSLSGTSYSFSSLENTVKTPSSFPSSL 214
                         SQ+QS   +       SS+   +  T+    S ++ ++TP +     
Sbjct: 723  VEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLH 782

Query: 215  SKERQSLPDTVNSLSAA--EDEGQPITFAVQV------HSPVPSEAGIHKALEN------ 260
              +   L D+V S SAA   +  +  T   Q       + P P        + N      
Sbjct: 783  YLQTLPLEDSVFSDSAAISPEHRRQSTLPTQKCHLQDHYGPYPLAESERMQVLNGNGGKP 842

Query: 261  -SFVTSESGFLNSLSSDDTSSLSSNHDHLTVPD------------KPAGSKIMDKEETKV 307
             SF        N    +   S     D +  P+            + AG  I +K E++ 
Sbjct: 843  RSFTLPRDSGFNHCCLNAPVSACDPQDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESRE 902

Query: 308  SE-DDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTL 366
             +  D ++ LY++LEQASLSPLG+ R STK E + SF+KRC +P +NEKLH++R L STL
Sbjct: 903  EKLGDSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTL 962

Query: 367  KCKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQDIYQ 406
            K +E ++A+I+++LD+P LT++++++WK M   L  DI Q
Sbjct: 963  KAREGEVAIIDKVLDNPDLTSKEFQQWKQMYLDLFLDICQ 1002


>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
           sapiens]
          Length = 713

 Score =  142 bits (357), Expect = 8e-34
 Identities = 66/192 (34%), Positives = 115/192 (59%), Gaps = 8/192 (4%)

Query: 20  RRKTQGFLT-MSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYS 78
           R+K++G  T +SRRR+SC++LG  DC GWL  +K  G F+  +W++ W +LKG +LYWY 
Sbjct: 374 RKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYR 433

Query: 79  NQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSA 138
               EKA+G +N+ ++++E   + KKK+ F+++H   K F FAA+ + ++++W+  L + 
Sbjct: 434 QPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITC 493

Query: 139 VIHQES-----TTKDEECYSESEQEDP--EIAAETPPPPHASQTQSLTAQQASSSSPSLS 191
           +   +S       ++E+CYSE+E EDP  E  + +  P  A     L    + +++P+  
Sbjct: 494 ISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQR 553

Query: 192 GTSYSFSSLENT 203
               SF SL ++
Sbjct: 554 SPRTSFGSLTDS 565



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 44/133 (33%), Positives = 77/133 (57%), Gaps = 8/133 (6%)

Query: 308 SEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLK 367
           S ++ +E + + L Q  +S LG  +P T+++ R SF++R ++P +NE++H++R L STLK
Sbjct: 565 SSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLK 624

Query: 368 CKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQD------IYQQQRASP--APDDTDD 419
            K  +L ++ ++L DP+LT  K+R+WK  N  L  +      + Q + +S     D T+ 
Sbjct: 625 AKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSEGLGAWGVAQAEGSSHILTSDSTEQ 684

Query: 420 TPQELKKSPSSPS 432
           +P  L   P   S
Sbjct: 685 SPHSLPSDPEEHS 697


>gi|219689123 pleckstrin homology domain containing, family A member
           5 isoform 2 [Homo sapiens]
          Length = 1105

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 7/115 (6%)

Query: 45  QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE--- 101
           +GWLYK+   G  L   WKK W +L    L++Y ++  E   G + LP F +   +    
Sbjct: 65  RGWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDH 121

Query: 102 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLN-KLGSAVIHQESTTKDEECYSES 155
             +K+AFK +HP ++T+YF  +  +EM +W+   L +A++  E   + ++  SE+
Sbjct: 122 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSEN 176


>gi|19923493 pleckstrin homology domain containing, family A member
           5 isoform 1 [Homo sapiens]
          Length = 1116

 Score = 70.9 bits (172), Expect = 2e-12
 Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 7/115 (6%)

Query: 45  QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASE--- 101
           +GWLYK+   G  L   WKK W +L    L++Y ++  E   G + LP F +   +    
Sbjct: 173 RGWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDH 229

Query: 102 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLN-KLGSAVIHQESTTKDEECYSES 155
             +K+AFK +HP ++T+YF  +  +EM +W+   L +A++  E   + ++  SE+
Sbjct: 230 INRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVKRVDKITSEN 284


>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
           sapiens]
          Length = 1048

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 6/132 (4%)

Query: 46  GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDF---TVERASEC 102
           GWL+K+   G     +W K W +L    L++Y ++  E   G + L  F    V+ +   
Sbjct: 64  GWLFKQASSGV---KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120

Query: 103 KKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEI 162
            +KH FK  H  ++T++F+AE+ +E   W+  +G A   Q    +     +     +   
Sbjct: 121 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD 180

Query: 163 AAETPPPPHASQ 174
           +   PP  H  Q
Sbjct: 181 SENVPPSKHHQQ 192


>gi|238859653 pleckstrin homology domain containing family A member
           4 isoform 2 [Homo sapiens]
          Length = 583

 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 13/189 (6%)

Query: 45  QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVE---RASE 101
           +GWL+K+   G  L   WK+ W +L G  L++Y +   E   G V LP + +      + 
Sbjct: 58  RGWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAP 114

Query: 102 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPE 161
             ++  F   HP ++T+  AA+ ++++  WL  LG A      +  + + Y +       
Sbjct: 115 RGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRA------SRAEGDDYGQPRSPARP 168

Query: 162 IAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSS-FPSSLSKERQS 220
              E P  P      S   +   S SP ++  S           +P++   S L   R  
Sbjct: 169 QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRAR 228

Query: 221 LPDTVNSLS 229
            PD    LS
Sbjct: 229 SPDLFTPLS 237


>gi|238859651 pleckstrin homology domain containing family A member
           4 isoform 1 [Homo sapiens]
          Length = 779

 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 46/189 (24%), Positives = 77/189 (40%), Gaps = 13/189 (6%)

Query: 45  QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVE---RASE 101
           +GWL+K+   G  L   WK+ W +L G  L++Y +   E   G V LP + +      + 
Sbjct: 58  RGWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAP 114

Query: 102 CKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPE 161
             ++  F   HP ++T+  AA+ ++++  WL  LG A      +  + + Y +       
Sbjct: 115 RGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGRA------SRAEGDDYGQPRSPARP 168

Query: 162 IAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSS-FPSSLSKERQS 220
              E P  P      S   +   S SP ++  S           +P++   S L   R  
Sbjct: 169 QPGEGPGGPGGPPEVSRGEEGRISESPEVTRLSRGRGRPRLLTPSPTTDLHSGLQMRRAR 228

Query: 221 LPDTVNSLS 229
            PD    LS
Sbjct: 229 SPDLFTPLS 237


>gi|239047795 pleckstrin homology domain containing, family A member
           7 [Homo sapiens]
          Length = 1121

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 27/130 (20%)

Query: 45  QGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERAS---E 101
           +GWL+K+   G  L   WK+ W +L    L++Y +   E   G + LP + +   +    
Sbjct: 168 RGWLHKQDSSGMRL---WKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDR 224

Query: 102 CKKKHAFKISH-------------------PQIKTFYFAAENVQEMNVWLNKLGSA--VI 140
             +K++FK  H                     ++T+YF+A+  ++MN W+  +  A  V+
Sbjct: 225 ISRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVL 284

Query: 141 HQESTTKDEE 150
            + S  +D E
Sbjct: 285 SRSSLKRDME 294


>gi|115527076 src kinase associated phosphoprotein 1 isoform 2 [Homo
           sapiens]
          Length = 358

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 30/127 (23%), Positives = 64/127 (50%), Gaps = 7/127 (5%)

Query: 37  KDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTV 96
           ++L +   QG+L KK +  SF  ++W+K W ++     Y+Y+N+ +++  G   +  + V
Sbjct: 103 QELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGV 162

Query: 97  ERA----SECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECY 152
             A     + KK+  F+++    +++ F A +  E   W++++   +    S T     Y
Sbjct: 163 RMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIP---Y 219

Query: 153 SESEQED 159
            E E+E+
Sbjct: 220 EEDEEEE 226


>gi|115527074 src kinase associated phosphoprotein 1 isoform 1 [Homo
           sapiens]
          Length = 359

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 30/127 (23%), Positives = 64/127 (50%), Gaps = 7/127 (5%)

Query: 37  KDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTV 96
           ++L +   QG+L KK +  SF  ++W+K W ++     Y+Y+N+ +++  G   +  + V
Sbjct: 103 QELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGV 162

Query: 97  ERA----SECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECY 152
             A     + KK+  F+++    +++ F A +  E   W++++   +    S T     Y
Sbjct: 163 RMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIP---Y 219

Query: 153 SESEQED 159
            E E+E+
Sbjct: 220 EEDEEEE 226


>gi|154354979 myosin X [Homo sapiens]
          Length = 2058

 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 7/123 (5%)

Query: 45   QGWLYKKKEKGSFLSNK-WKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECK 103
            QGWL+KK    S LS + WKK W +L+ S L ++ N   EK  G V +     E      
Sbjct: 1216 QGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVEVRT-AKEIIDNTT 1274

Query: 104  KKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIA 163
            K++   I     +TF+  AE+ ++ + W + L    +H  +  + +E +   EQ +P+ A
Sbjct: 1275 KENGIDIIMAD-RTFHLIAESPEDASQWFSVLSQ--VHASTDQEIQEMH--DEQANPQNA 1329

Query: 164  AET 166
              T
Sbjct: 1330 VGT 1332



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 32/152 (21%), Positives = 67/152 (44%), Gaps = 10/152 (6%)

Query: 58   LSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLP---DFTVERASECKKKHAFKISHPQ 114
            L N WK+ W +LK  +  W+ ++      G+++       T+ R +  K+    +    Q
Sbjct: 1188 LMNSWKRRWCVLKDETFLWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLR----Q 1243

Query: 115  IKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQ 174
             K  YF  ++ +++   + ++ +A    ++TTK+             + AE+  P  ASQ
Sbjct: 1244 SKLMYFENDSEEKLKGTV-EVRTAKEIIDNTTKENGIDIIMADRTFHLIAES--PEDASQ 1300

Query: 175  TQSLTAQQASSSSPSLSGTSYSFSSLENTVKT 206
              S+ +Q  +S+   +       ++ +N V T
Sbjct: 1301 WFSVLSQVHASTDQEIQEMHDEQANPQNAVGT 1332


>gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens]
          Length = 359

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 32/130 (24%), Positives = 59/130 (45%), Gaps = 4/130 (3%)

Query: 34  ISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPD 93
           I+ +DL      G+L K+++  SFL  +W+K W  L  +  Y+Y +   ++  G   +  
Sbjct: 109 IAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDG 168

Query: 94  FTVER----ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDE 149
           ++V        + KK   F+IS P  + + F A + ++   W+ +L   +   ES    E
Sbjct: 169 YSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPE 228

Query: 150 ECYSESEQED 159
           +     E  D
Sbjct: 229 DYDERGELYD 238


>gi|126091130 Gab3 protein isoform 1 [Homo sapiens]
          Length = 587

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 60/249 (24%), Positives = 93/249 (37%), Gaps = 36/249 (14%)

Query: 40  GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 92
           G A C GWL K   +       W+K W +L+          L +Y N+ + K    ++L 
Sbjct: 4   GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63

Query: 93  DFTVER-------ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQEST 145
           +  V +         E +    F I     +TFY  A+  QEM VW        +H  S 
Sbjct: 64  ECAVWKHVGPSFVRKEFQNNFVF-IVKTTSRTFYLVAKTEQEMQVW--------VHSISQ 114

Query: 146 TKDEECYSESEQEDPEIAAETPPPPHASQTQS-LTAQQASSSSPSLSGTSYSFSSLENTV 204
             +     +   +  E  + TP     S   S LTA  ASSS P     + + ++ E   
Sbjct: 115 VCNLGHLEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRS 174

Query: 205 KTPSSF-PSSL--------SKERQSLPDTVNSLSAAEDEGQPITF---AVQVHSPVPSEA 252
           ++   F P  L             SLP   +S S ++   +  +F    V    P+PS  
Sbjct: 175 ESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSH 234

Query: 253 GIHKALENS 261
            +H +   S
Sbjct: 235 LVHPSCHGS 243


>gi|18079323 Gab3 protein isoform 2 [Homo sapiens]
          Length = 586

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 59/249 (23%), Positives = 93/249 (37%), Gaps = 37/249 (14%)

Query: 40  GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 92
           G A C GWL K   +       W+K W +L+          L +Y N+ + K    ++L 
Sbjct: 4   GDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVIDLS 63

Query: 93  DFTVER-------ASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQEST 145
           +  V +         E +    F I     +TFY  A+  QEM VW++ +          
Sbjct: 64  ECAVWKHVGPSFVRKEFQNNFVF-IVKTTSRTFYLVAKTEQEMQVWVHSISQVC------ 116

Query: 146 TKDEECYSESEQEDPEIAAETPPPPHASQTQS-LTAQQASSSSPSLSGTSYSFSSLENTV 204
                 + E   +  E  + TP     S   S LTA  ASSS P     + + ++ E   
Sbjct: 117 ---NLGHLEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRS 173

Query: 205 KTPSSF-PSSL--------SKERQSLPDTVNSLSAAEDEGQPITF---AVQVHSPVPSEA 252
           ++   F P  L             SLP   +S S ++   +  +F    V    P+PS  
Sbjct: 174 ESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSH 233

Query: 253 GIHKALENS 261
            +H +   S
Sbjct: 234 LVHPSCHGS 242


>gi|18105042 GRB2-associated binding protein 2 isoform a [Homo
           sapiens]
          Length = 676

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 61/269 (22%), Positives = 101/269 (37%), Gaps = 28/269 (10%)

Query: 40  GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNLP 92
           G   C GWL K   +       WKK W IL+          L +Y N  ++K    +NL 
Sbjct: 5   GDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINL- 63

Query: 93  DFTVE-------RASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAV-IHQES 144
           +F  +          E +    F I   + +TFY  AE  ++MN W+  +      +Q  
Sbjct: 64  NFCEQVDAGLTFNKKELQDSFVFDIKTSE-RTFYLVAETEEDMNKWVQSICQICGFNQAE 122

Query: 145 TTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTV 204
            + D      S    P     +P    +S    L  +++S+ S S   T ++F    +  
Sbjct: 123 ESTDSLRNVSSAGHGPR---SSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNH 179

Query: 205 KTPSSFPSSLSKERQSLPDTV-----NSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALE 259
             P +  +S  +E   L   +     N+ SA+  +G   +F ++  + V   A  +    
Sbjct: 180 MQP-TLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCV 238

Query: 260 NSFVTSESGF--LNSLSSDDTSSLSSNHD 286
           N       GF  L   S  +T    S +D
Sbjct: 239 NGISGQVHGFYSLPKPSRHNTEFRDSTYD 267


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 42/159 (26%), Positives = 69/159 (43%), Gaps = 20/159 (12%)

Query: 50  KKKEKGSFLSNKWKKFWVILKGSSLY----------WY-SNQMAEKADGFVNLPDFTVER 98
           K  E G  +   W   W +L+GSSL           W+ SNQ   K +  V+L   T+E 
Sbjct: 474 KIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQ--SKPEFTVDLKGATIEM 531

Query: 99  ASECK--KKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKD--EECYSE 154
           AS+ K  KK+ F++   Q       ++N   +N W   L S + +Q   T +  EE   +
Sbjct: 532 ASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPD 591

Query: 155 S---EQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSL 190
           S   E+ D E   + P    + +  S+ + +   +  +L
Sbjct: 592 SPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNL 630


>gi|20149626 pleckstrin homology domain containing, family O member
           1 [Homo sapiens]
          Length = 409

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 44/189 (23%), Positives = 71/189 (37%), Gaps = 19/189 (10%)

Query: 46  GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKAD--GFVNLPDFTV-----ER 98
           GW+ K   KG F    WK  +V+LKG  LY    ++ ++ +     +L D+       + 
Sbjct: 26  GWVRKFCGKGIF-REIWKNRYVVLKGDQLYISEKEVKDEKNIQEVFDLSDYEKCEELRKS 84

Query: 99  ASECKKKHA-FKISHPQ-----IKTFYFAAENVQEMNVWLNKLGSAVIHQ-----ESTTK 147
            S  KK H+ F ++H +          F A + +E   W+N L SA+        +  T 
Sbjct: 85  KSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEKESWINALNSAITRAKNRILDEVTV 144

Query: 148 DEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTP 207
           +E+ Y      D      +  PP      ++ +   S    +L        S E      
Sbjct: 145 EEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPTSCA 204

Query: 208 SSFPSSLSK 216
            SF   L K
Sbjct: 205 ESFRVDLDK 213


>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
           sapiens]
          Length = 699

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 58/233 (24%), Positives = 88/233 (37%), Gaps = 43/233 (18%)

Query: 143 ESTTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLEN 202
           +S++ +EE  S  E++  ++ A T P   A    SL A+QA   S   S  S S SS E 
Sbjct: 422 DSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEE 481

Query: 203 TVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALENSF 262
             KT                    S SA + + Q +        P  ++ G         
Sbjct: 482 EEKT--------------------SKSAVKKKPQKVAGGAAPSKPASAKKG--------- 512

Query: 263 VTSESGFLNSLSSDDTS-----SLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEMEKLY 317
             +ES   NS SSDD+S      L           K  G+  +  +  K +++ E E+  
Sbjct: 513 -KAESS--NSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEE 569

Query: 318 KSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLKCKE 370
           K      +S  G    S KK  +    K  + P    K  K++T N+  K K+
Sbjct: 570 KKKAAVVVSKSG----SLKKRKQNEAAKEAETP--QAKKIKLQTPNTFPKRKK 616



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 63/290 (21%), Positives = 109/290 (37%), Gaps = 39/290 (13%)

Query: 79  NQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSA 138
           NQ++E A+ F         +A+   ++ A   S   I +F+  +  V E  +  N   + 
Sbjct: 25  NQLSEVANKFA--------KATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAK 76

Query: 139 VIHQESTTKDEECYSESEQE---DPEIAAETPP-----PPHASQTQSLTAQQASSSSPSL 190
              +++++ D E  SE E+E    P   A  P      PP  +  ++  +  +  SS   
Sbjct: 77  KAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDD 136

Query: 191 SGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEG--------QPITFAV 242
                    ++  VK  +    +  K+ +S     +S S++EDE          P+T   
Sbjct: 137 DEEDQKKQPVQKGVKPQAKAAKAPPKKAKS--SDSDSDSSSEDEPPKNQKPKITPVTVKA 194

Query: 243 QVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDT-SSLSSNHDHLTVPDKPAGSKIMD 301
           Q  +P        K       +S S   +S SSDD+    ++     TVP K   +K   
Sbjct: 195 QTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV 254

Query: 302 K------------EETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKKEL 339
           K            E++   E++E +K  K+      S      P  KK L
Sbjct: 255 KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSL 304



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 53/230 (23%), Positives = 88/230 (38%), Gaps = 35/230 (15%)

Query: 142 QESTTKDEECYSESEQEDPE----------IAAET--PPPPHASQTQSLTAQQASSSSPS 189
           +++ + D +  S SE E P+          + A+T  PP P  +  +    + ASSSS S
Sbjct: 162 KKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSS 221

Query: 190 LSGTSYSFSSLENTVKTP------------SSFPSSLSKERQSLPDTVNSLSAAEDEGQP 237
            S +S   S  E    TP            +   ++ +  R+S     +S    E++ +P
Sbjct: 222 SSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKP 281

Query: 238 ITFAVQVHS--PVPSEAGIHKAL----ENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVP 291
           +      +S  P PS     K+L        V  +    +S  S D S  SS+ +    P
Sbjct: 282 MKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESD-SSSEEEKKPP 340

Query: 292 DKPAGSKIMDK----EETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKK 337
            K   SK   K    ++   S  D  +      ++A   P G  + S+ K
Sbjct: 341 TKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNK 390



 Score = 34.3 bits (77), Expect = 0.23
 Identities = 52/230 (22%), Positives = 84/230 (36%), Gaps = 42/230 (18%)

Query: 143 ESTTKDEECYSESEQEDPEIA----AETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFS 198
           E ++ + +  SE E++ P  A    A T PPP     +S +    S SS      S    
Sbjct: 323 EDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAG 382

Query: 199 SLEN-------TVKTPSSFPSSLSKE-----RQSLPDTVNSLSAAED----EGQPITFAV 242
           + +N       T K+P+  P++  K+     ++ L    +S S+ E+    E +     V
Sbjct: 383 TTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMV 442

Query: 243 QVHSPVPSEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLT------------- 289
               P   +A    AL      +  G  +S S  D+SS     +  +             
Sbjct: 443 ATTKP---KATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAG 499

Query: 290 --VPDKPAGSKIMDKEETKVSEDDEMEKLYKSLEQASLSPLGDRRPSTKK 337
              P KPA +K    E +  S  D+  +     E+  L   G  RP   K
Sbjct: 500 GAAPSKPASAKKGKAESSNSSSSDDSSE----EEEEKLKGKGSPRPQAPK 545


>gi|83716021 GRB2-associated binding protein family, member 4 [Homo
           sapiens]
          Length = 574

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 44/168 (26%), Positives = 66/168 (39%), Gaps = 22/168 (13%)

Query: 40  GHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSS-------LYWYSNQMAEKADGFVNL- 91
           GH    GWL K   +       W+K W IL+          L +Y N  ++K    +NL 
Sbjct: 38  GHVLYSGWLRKSPPEKKLRLFAWRKRWFILRRGQTSSDPDVLEYYKNDGSKKPLRTINLN 97

Query: 92  ------PDFTVE-RASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAV-IHQE 143
                  D T+     E +K + F I   + +TFY  AE  ++MN W+  +       QE
Sbjct: 98  LCEQLDVDVTLNFNKKEIQKGYMFDIKTSE-RTFYLVAETREDMNEWVQSICQICGFRQE 156

Query: 144 STTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLS 191
            +T      S +          +P  P  S  Q L  +Q  +S P +S
Sbjct: 157 ESTGFLGNISSASHG----LCSSPAEPSCSH-QHLPQEQEPTSEPPVS 199


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 40/165 (24%), Positives = 68/165 (41%), Gaps = 33/165 (20%)

Query: 42   ADCQGWLYKKKE------KGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGF------- 88
            A  +G+L +K E      K S  S  W   + ++    + +Y +     A G        
Sbjct: 2198 AQMEGFLNRKHEWEAHNKKAS--SRSWHNVYCVINNQEMGFYKDAKTA-ASGIPYHSEVP 2254

Query: 89   VNLPDFTVERASECKKK-HAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTK 147
            V+L +   E A + KKK H FK+       + F A++ +EMN W+  + SA+        
Sbjct: 2255 VSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAI-------- 2306

Query: 148  DEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSG 192
                      +  E++A T   P +S+ Q+L     + +S S  G
Sbjct: 2307 --------SSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPG 2343


>gi|46195763 metastasis suppressor 1-like [Homo sapiens]
          Length = 747

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 41/141 (29%), Positives = 68/141 (48%), Gaps = 12/141 (8%)

Query: 190 LSGTSYSFSSLENTVKTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVP 249
           L G+ YS+S      +TP S PSS S  + S+    +S S+A+  G P     Q +S  P
Sbjct: 249 LKGSDYSWS-----YQTPPSSPSSSSSRKSSMCSAPSSSSSAKGGGAPWPGGAQTYS--P 301

Query: 250 SEAGIHKALENSFVTSESGFLNSLSSDDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSE 309
           S    +++L     T+    L+S+SS D+  +S +  + + P  P  S I  ++ +  S 
Sbjct: 302 SSTCRYRSLAQPATTTAR--LSSVSSHDSGFVSQDATY-SKPPSPMPSDITSQKSSS-SA 357

Query: 310 DDEMEKLYKSLEQASLSPLGD 330
             E  +  +S+ + S SP  D
Sbjct: 358 SSEASETCQSVSECS-SPTSD 377


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 50/193 (25%), Positives = 74/193 (38%), Gaps = 10/193 (5%)

Query: 158  EDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTVKTPSSFPSSLSKE 217
            + P   A   P      + S ++  +SSSS S S +S S S   ++    SS P      
Sbjct: 2516 QQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVA 2575

Query: 218  RQSLPDTVNSLSAAEDEGQP--ITFAVQVHSPVPSEAGIHKALENSFVTSESGFLNSLSS 275
             + +P    +   A  EG+P   T A +      S +    +  +S  +S S   +S SS
Sbjct: 2576 LKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2635

Query: 276  DDTSSLSSNHDHLTVPDKPAGSKIMDKEETKVSEDDEM-----EKLYKSLEQA---SLSP 327
              +SS SS+      P KP    +      K     E       K   SL  +   S SP
Sbjct: 2636 SSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSP 2695

Query: 328  LGDRRPSTKKELR 340
            +  RRPS +   R
Sbjct: 2696 VERRRPSPQPSPR 2708



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 24/78 (30%), Positives = 36/78 (46%)

Query: 145  TTKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSYSFSSLENTV 204
            T   +E   E    +P  A        +S + S ++  +SSSS S S +S S SS  ++ 
Sbjct: 2583 TPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2642

Query: 205  KTPSSFPSSLSKERQSLP 222
             + SS PS      Q+LP
Sbjct: 2643 SSSSSSPSPAKPGPQALP 2660



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 50/206 (24%), Positives = 80/206 (38%), Gaps = 31/206 (15%)

Query: 146  TKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSS--PSLSGTSYSFSSLENT 203
            T   + +S S    P++ A+TPP P  S ++S   Q+ S  S   S  G+    + ++++
Sbjct: 983  TPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSS 1042

Query: 204  VKTPSSF----PSSLSKERQSLPDTVNSLSAAEDEGQPITFAVQVHSPVPSEAGIHKALE 259
                 S+       L  + Q+ PD  +  S+ E          Q HS  PS       L+
Sbjct: 1043 TPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPE--------VRQSHSESPS-------LQ 1087

Query: 260  NSFVTSESGFLNSLSSDDTSSLSS----NHDHLTVPDKPAGSKIMDKEETKVSEDDEMEK 315
            +   TS  G   S SS   + L+S      D       P     M  E+++   D     
Sbjct: 1088 SKSQTSPKGG-RSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSS-- 1144

Query: 316  LYKSLEQASLSPLGDRRPSTKKELRK 341
             Y +++  SL  LG  R  T +   K
Sbjct: 1145 -YPTVDSNSL--LGQSRLETAESKEK 1167


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 55/239 (23%), Positives = 105/239 (43%), Gaps = 21/239 (8%)

Query: 30   SRRRISCKDLGHADCQGWLYKKK---EKGSFLSNK---WKKFWVILKGSSLYWYSNQMAE 83
            SR+  S +    A  +GWL+ +    +KG  +      WK+ +V+L+G SLY Y ++  +
Sbjct: 920  SRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQ 979

Query: 84   KADGFVNLPDFTVERA------SECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKL-G 136
                    P  +V         SE K+K+ F+++    +   F AE+  +M  W+  +  
Sbjct: 980  TTPSEEEQP-ISVNACLIDISYSETKRKNVFRLTTSDCECL-FQAEDRDDMLAWIKTIQE 1037

Query: 137  SAVIHQEST-TKDEECYSESEQEDPEIAAETPPPPHASQTQSLTAQQASSSSPSLSGTSY 195
            S+ +++E T   + +  S   +E   + ++    P   + QSL+ +Q    + S   T  
Sbjct: 1038 SSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPR-QSLSIRQTLLGAKSEPKTQS 1096

Query: 196  SFSSLENTV-KTPSSFPSSLSKERQSLPDTVNSLSAAEDEGQPI---TFAVQVHSPVPS 250
              S  E +  K  S   +S  K++ +    + S+     E +P    TF V++    P+
Sbjct: 1097 PHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPA 1155


>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
           2 [Homo sapiens]
          Length = 1704

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 29/104 (27%), Positives = 51/104 (49%), Gaps = 7/104 (6%)

Query: 46  GWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERASECKKK 105
           GWL K   +G  +   ++K WV   G S+ +Y+N+    + G + L   +  R     K 
Sbjct: 487 GWLDKLSPQGKRM---FQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNK- 542

Query: 106 HAFKISHPQIKTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDE 149
             F++   Q +TF F  E  +E N W++ L +A+  Q  T++ +
Sbjct: 543 --FEVVTTQ-RTFVFRVEKEEERNDWISILLNALKSQSLTSQSQ 583



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 26/103 (25%), Positives = 40/103 (38%), Gaps = 24/103 (23%)

Query: 47  WLYKKKEKGSFLSNKWK------KFWVILKGSSLYWYSNQMAEKADGFVNLPDFTVERAS 100
           +LY+     S LS++ K      K W +L+G  L +Y N  +   +G +N+ +       
Sbjct: 898 FLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVI----- 952

Query: 101 ECKKKH------------AFKISHPQIKTFYFAAENVQEMNVW 131
            C   H             F+I  P  + F F AE  Q    W
Sbjct: 953 -CLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKW 994


>gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sapiens]
          Length = 2365

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 16/174 (9%)

Query: 59   SNKWKKFWVILKGSSLYWYSNQMAEKA---DGFVNLPDFTVERASECKKKHAFKISHPQI 115
            +++WKK W +L  SSL +Y +  AE+A   DG ++L   T       ++ + F+I H + 
Sbjct: 1804 TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQI-HTKD 1862

Query: 116  KTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQT 175
              +  +A        W+  L   V  + ++  D    S+S +E+   +  T   P  +  
Sbjct: 1863 AVYTLSAMTSGIRRNWIEALRKTV--RPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGE 1920

Query: 176  QSLTAQQASSSSP-SLSGTSYSFSSLE---------NTVKTPSSFPSSLSKERQ 219
            Q   ++  S   P    G   +   +E            +TP+  P  L+K+ +
Sbjct: 1921 QRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEE 1974


>gi|88501741 TRIO and F-actin binding protein isoform 2 [Homo
           sapiens]
          Length = 431

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 16/174 (9%)

Query: 59  SNKWKKFWVILKGSSLYWYSNQMAEKA---DGFVNLPDFTVERASECKKKHAFKISHPQI 115
           +++WKK W +L  SSL +Y +  AE+A   DG ++L   T       ++ + F+I H + 
Sbjct: 91  TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQI-HTKD 149

Query: 116 KTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQT 175
             +  +A        W+  L   V  + ++  D    S+S +E+   +  T   P  +  
Sbjct: 150 AVYTLSAMTSGIRRNWIEALRKTV--RPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGE 207

Query: 176 QSLTAQQASSSSP-SLSGTSYSFSSLE---------NTVKTPSSFPSSLSKERQ 219
           Q   ++  S   P    G   +   +E            +TP+  P  L+K+ +
Sbjct: 208 QRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEE 261


>gi|88501740 TRIO and F-actin binding protein isoform 1 [Homo
           sapiens]
          Length = 652

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 39/174 (22%), Positives = 73/174 (41%), Gaps = 16/174 (9%)

Query: 59  SNKWKKFWVILKGSSLYWYSNQMAEKA---DGFVNLPDFTVERASECKKKHAFKISHPQI 115
           +++WKK W +L  SSL +Y +  AE+A   DG ++L   T       ++ + F+I H + 
Sbjct: 91  TSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQI-HTKD 149

Query: 116 KTFYFAAENVQEMNVWLNKLGSAVIHQESTTKDEECYSESEQEDPEIAAETPPPPHASQT 175
             +  +A        W+  L   V  + ++  D    S+S +E+   +  T   P  +  
Sbjct: 150 AVYTLSAMTSGIRRNWIEALRKTV--RPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGE 207

Query: 176 QSLTAQQASSSSP-SLSGTSYSFSSLE---------NTVKTPSSFPSSLSKERQ 219
           Q   ++  S   P    G   +   +E            +TP+  P  L+K+ +
Sbjct: 208 QRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEE 261


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.124    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,065,184
Number of Sequences: 37866
Number of extensions: 850837
Number of successful extensions: 5512
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 107
Number of HSP's successfully gapped in prelim test: 369
Number of HSP's that attempted gapping in prelim test: 4810
Number of HSP's gapped (non-prelim): 1013
length of query: 437
length of database: 18,247,518
effective HSP length: 105
effective length of query: 332
effective length of database: 14,271,588
effective search space: 4738167216
effective search space used: 4738167216
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.