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Search of human proteins with 39995086
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
(584 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39995086 solute carrier family 24 member 6 [Homo sapiens] 1174 0.0
gi|29788985 solute carrier family 24 member 4 isoform 2 precurso... 119 6e-27
gi|45504369 solute carrier family 24, member 5 [Homo sapiens] 94 3e-19
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e... 81 2e-15
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 78 2e-14
gi|9966787 solute carrier family 24 (sodium/potassium/calcium ex... 78 3e-14
gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo sa... 77 6e-14
gi|24111228 solute carrier family 24 member 4 isoform 1 precurso... 77 6e-14
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 37 0.050
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 37 0.066
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 37 0.066
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 37 0.066
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 37 0.066
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 34 0.33
gi|33946308 solute carrier family 8 (sodium/calcium exchanger), ... 34 0.33
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 34 0.33
gi|194354001 solute carrier family 8 (sodium/calcium exchanger),... 34 0.33
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 34 0.33
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 34 0.33
gi|94721340 SID1 transmembrane family, member 2 [Homo sapiens] 34 0.33
gi|5453613 CD7 antigen precursor [Homo sapiens] 32 1.6
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 32 2.1
gi|72534746 tetraspanin 18 isoform 1 [Homo sapiens] 30 4.7
gi|42476204 tetraspanin 18 isoform 2 [Homo sapiens] 30 4.7
gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens] 30 4.7
gi|4755125 aquaporin 4 isoform b [Homo sapiens] 30 6.1
gi|4502181 aquaporin 4 isoform a [Homo sapiens] 30 6.1
gi|31657114 armadillo repeat containing 4 [Homo sapiens] 30 6.1
gi|29725635 otopetrin 1 [Homo sapiens] 30 8.0
>gi|39995086 solute carrier family 24 member 6 [Homo sapiens]
Length = 584
Score = 1174 bits (3037), Expect = 0.0
Identities = 584/584 (100%), Positives = 584/584 (100%)
Query: 1 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN 60
MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
Sbjct: 1 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN 60
Query: 61 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK 120
VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
Sbjct: 61 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK 120
Query: 121 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL 180
FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL
Sbjct: 121 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL 180
Query: 181 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY 240
VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY
Sbjct: 181 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY 240
Query: 241 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET 300
VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
Sbjct: 241 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET 300
Query: 301 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC 360
TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
Sbjct: 301 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC 360
Query: 361 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL 420
LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL
Sbjct: 361 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL 420
Query: 421 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR 480
FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR
Sbjct: 421 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR 480
Query: 481 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF 540
QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF
Sbjct: 481 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF 540
Query: 541 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM 584
SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
Sbjct: 541 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM 584
>gi|29788985 solute carrier family 24 member 4 isoform 2 precursor
[Homo sapiens]
Length = 586
Score = 119 bits (299), Expect = 6e-27
Identities = 125/503 (24%), Positives = 220/503 (43%), Gaps = 34/503 (6%)
Query: 99 AVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSAL 158
AV L++ LY+F L + FF P+L I L LS +VAG TF+A G+ P++F+++
Sbjct: 82 AVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASV 141
Query: 159 VAFSDPHTAGLALGALFGAGVLVTTVVAG--GITILHPFMAASRPFFRDIVFYMVAVFLT 216
+ H + +G + G+ V + G G+ RD V+Y ++V +
Sbjct: 142 IGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVL 200
Query: 217 FLMLFRGRVTLAWALGYLGLYVFYVV----TVILCTWIYQRQRRGSLFCPMPVTPEILSD 272
+ ++ ++ L + LYVFY++ V + + +Q+ S+ PV E+ +
Sbjct: 201 IVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQK--SIANGNPVNSELEAV 258
Query: 273 SEEDRVSSNTNSY--DYGDEYRPLFFYQETTAQILV-RALNPLDYMKW-------RRKSA 322
E+ + N + P F + E +I++ P ++ R+
Sbjct: 259 KEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRL 318
Query: 323 YWKALKVFKLPV-----EFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSG 377
A V P+ E + VPV +P+ QN ++ P V S
Sbjct: 319 INSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLS- 377
Query: 378 TYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAA 437
+ V E G WV L + + PR F + F+T+ LWI +
Sbjct: 378 PFSVPEARGDKVKWVFT----WPLIFLLCVTIPNCSKPRWEKFF-MVTFITATLWIAVFS 432
Query: 438 TEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIF 497
+V ++ +G + + ++G+T LA G S+ D + +ARQG MA S G +F
Sbjct: 433 YIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVF 492
Query: 498 NILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRV 555
+ILVG+G+ G + + VK+ G LV+ + LG S+ +++ + L ++L R
Sbjct: 493 DILVGLGVPWGLQTMVVNYGSTVKINSRG-LVYSVVLLLG-SVALTVLGIHLNKWRLDRK 550
Query: 556 YGFCLLLFYLNFLVVALLTEFGV 578
G +L+ Y FL +++ EF V
Sbjct: 551 LGVYVLVLYAIFLCFSIMIEFNV 573
Score = 37.7 bits (86), Expect = 0.029
Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 31/162 (19%)
Query: 98 LAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSA 157
+ TL+++ Y+ + L ++ I TL + + G+TFLA G PD ++
Sbjct: 422 ITATLWIAVFSYIMVWL-----------VTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 470
Query: 158 LVA-------FSDPHTAGL-ALGALFGAGV---LVTTVVAGGITILHPFMAASRPFFRDI 206
L+ + +T G L G GV L T VV G T+ SR +
Sbjct: 471 LIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTV----KINSRGLVYSV 526
Query: 207 VFYMVAVFLTFLMLFRGRVTLAWALG-YLGLYVFYVVTVILC 247
V + +V LT L + + W L LG+YV + + LC
Sbjct: 527 VLLLGSVALTVLGIHLNK----WRLDRKLGVYVLVLYAIFLC 564
>gi|45504369 solute carrier family 24, member 5 [Homo sapiens]
Length = 500
Score = 94.4 bits (233), Expect = 3e-19
Identities = 110/498 (22%), Positives = 203/498 (40%), Gaps = 94/498 (18%)
Query: 100 VTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALV 159
+ +Y ++Y+F+ + + ++F P+L IS +L LS +VAG TF+A G+ AP++ +A +
Sbjct: 69 IIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFL 128
Query: 160 AFSDPHTAGLALGALFGAGV--LVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTF 217
+ + + G+ + L+ A G+ + P FRD Y ++
Sbjct: 129 GVFIT-KGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVL 187
Query: 218 LMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQ---RRGSLFCPMPVTPEILSDSE 274
+++ +V W G L L ++ + ++LC I Q ++ S C S+ +
Sbjct: 188 GIIYDNQV--YWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAMERSEQQ 245
Query: 275 -----ED------RVSSNTNSYDYGDE--YRPLFFYQETTAQILVRALNPLDYMKWRRKS 321
ED R S T+S + ++ Y L +Q+ + + + K
Sbjct: 246 PLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKR 305
Query: 322 AYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGV 381
+W V LP+ LL LT PD + WK + VI+ + + + + TY
Sbjct: 306 IFW----VLSLPIITLLFLTT----PDCRKKFWKN-----YFVITFFMSAIWISAFTY-- 350
Query: 382 YEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVV 441
+ VW+V + T
Sbjct: 351 ------ILVWMVTITGET------------------------------------------ 362
Query: 442 NILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILV 501
+ +TV+GLTLLA G SI D + +AR+G MA S G +F++L
Sbjct: 363 ---------LEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC 413
Query: 502 GVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLL 561
+G+ ++ + + E + + + +L +S++F ++V ++L R G L
Sbjct: 414 -LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCL 472
Query: 562 LFYLNFLVVALLTEFGVI 579
L YL +++L E G+I
Sbjct: 473 LSYLGLATLSVLYELGII 490
>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
Length = 644
Score = 81.3 bits (199), Expect = 2e-15
Identities = 58/180 (32%), Positives = 92/180 (51%), Gaps = 5/180 (2%)
Query: 401 LASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGL 460
L+ V +F + PR F + F +S LWI A + +V ++ +G + + ++G+
Sbjct: 456 LSFVLYFTVPNCNKPRWEKWF-MVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGI 514
Query: 461 TLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSH--TEV 518
T LA G S+ D + +ARQG MA S G +F+IL+G+GL LQ + +
Sbjct: 515 TFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYI 574
Query: 519 KLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGV 578
+L GL+ V G L S+ ++ V L +QL + G LL Y FL +++TEF V
Sbjct: 575 RLNSRGLIYSV--GLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNV 632
Score = 67.4 bits (163), Expect = 3e-11
Identities = 42/156 (26%), Positives = 79/156 (50%), Gaps = 3/156 (1%)
Query: 99 AVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSAL 158
AV L+V +Y+F L + FF P+L I L LS +VAG TF+A G+ AP++F+++
Sbjct: 109 AVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSV 168
Query: 159 VAFSDPHTAGLALGALFGAGVLVTTVVAG--GITILHPFMAASRPFFRDIVFYMVAVFLT 216
+ + +G + G+ V + G G+ +S RD ++Y ++V
Sbjct: 169 IGVFIT-KGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIAL 227
Query: 217 FLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQ 252
+ ++ +V+ +L + +Y+ Y+V + I+Q
Sbjct: 228 IVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQ 263
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 78.2 bits (191), Expect = 2e-14
Identities = 51/181 (28%), Positives = 86/181 (47%), Gaps = 20/181 (11%)
Query: 72 PDCHSDGGYLDYLEGIFCHFPPSLLPLA------VTLYVSWLLYLFLILGVTAAKFFCPN 125
PD H G Y PP L + V L+V ++Y+F+ L + ++F P
Sbjct: 432 PDLHPKGEY-----------PPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPA 480
Query: 126 LSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVV 185
L I+ L++S +VAG TF+A G AP++F++L+ H + + +G + G+ V V
Sbjct: 481 LGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISH-SNVGIGTIVGSAVFNILFV 539
Query: 186 AGGITILHPFMAASR--PFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVT 243
G ++ + P FRD+ FY++ + + L + +L L Y FYV T
Sbjct: 540 IGTCSLFSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFT 599
Query: 244 V 244
+
Sbjct: 600 M 600
Score = 73.2 bits (178), Expect = 6e-13
Identities = 51/168 (30%), Positives = 89/168 (52%), Gaps = 6/168 (3%)
Query: 413 QPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDA 472
Q R ++F FLG S +WI + +V +G +S ++GLT+LA G SI D
Sbjct: 931 QESRKFFVFTFLG---SIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDL 987
Query: 473 FSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLL-QISRSHTEVKLEPDGLLVWVLA 531
+ +AR+G MA S+ G IF+I VG+ + LL + V + +GL ++
Sbjct: 988 ITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIV- 1046
Query: 532 GALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVI 579
L L L+F + S+ ++++++ GF + L Y FL+++++ E +I
Sbjct: 1047 -LLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRII 1093
Score = 34.3 bits (77), Expect = 0.33
Identities = 29/132 (21%), Positives = 57/132 (43%), Gaps = 19/132 (14%)
Query: 129 ISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTV---- 184
+ T+ +S + G+T LA G PD+ ++++ + +A+ + G+ + TV
Sbjct: 962 VGETIGISEEIMGLTILAAGTSIPDLITSVIV-ARKGLGDMAVSSSVGSNIFDITVGLPV 1020
Query: 185 ---VAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALG-------YL 234
+ I L P +S F IV +FL L + + W + +L
Sbjct: 1021 PWLLFSLINGLQPVPVSSNGLFCAIVL----LFLMLLFVISSIASCKWRMNKILGFTMFL 1076
Query: 235 GLYVFYVVTVIL 246
+VF +++V+L
Sbjct: 1077 LYFVFLIISVML 1088
>gi|9966787 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 2 [Homo sapiens]
Length = 661
Score = 77.8 bits (190), Expect = 3e-14
Identities = 64/262 (24%), Positives = 121/262 (46%), Gaps = 23/262 (8%)
Query: 11 ALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRT 70
A+S + + A + + T+ + + +S A G +Q ++D ++D+
Sbjct: 48 AISTVSFSISAFSETDTQSTGEASVVSGPRVAQGYHQRTLLD--------LNDKILDYTP 99
Query: 71 NPDCHSDGGYLDYLEGIFCHFPPSLLPL------AVTLYVSWLLYLFLILGVTAAKFFCP 124
P +G + + +P + L A+ L+V ++Y+F+ L + +FF P
Sbjct: 100 QPPLSKEGESENSTDHAQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVP 159
Query: 125 NLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTV 184
+L+ I+ L +S +VAG TF+A G AP++F++L+ H + + +G + G+ V
Sbjct: 160 SLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAH-SNVGIGTIVGSAVFNILF 218
Query: 185 VAGGITILHPFMAASR--PFFRDIVFYMVAVFLTFLMLFRGRVTLAW-ALGYLGLYVFYV 241
V G + + P FRD+ FY+V + + ++ F V + W +L L Y YV
Sbjct: 219 VIGMCALFSREILNLTWWPLFRDVSFYIVDLIM-LIIFFLDNVIMWWESLLLLTAYFCYV 277
Query: 242 V----TVILCTWIYQRQRRGSL 259
V V + W+ Q R +
Sbjct: 278 VFMKFNVQVEKWVKQMINRNKV 299
Score = 70.1 bits (170), Expect = 5e-12
Identities = 48/151 (31%), Positives = 80/151 (52%), Gaps = 3/151 (1%)
Query: 426 FLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPR 485
F S WI + +V +G +S ++GLT+LA G SI D + +AR+G
Sbjct: 503 FFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGD 562
Query: 486 MAFSACFGGIIFNILVGVGLGCLL-QISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVS 544
MA S+ G IF+I VG+ L LL + V + +GL ++ L + L+F ++S
Sbjct: 563 MAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSSNGLFCAIV--LLFIMLLFVILS 620
Query: 545 VPLQCFQLSRVYGFCLLLFYLNFLVVALLTE 575
+ L ++++++ GF + Y FLVV++L E
Sbjct: 621 IALCKWRMNKILGFIMFGLYFVFLVVSVLLE 651
Score = 38.1 bits (87), Expect = 0.023
Identities = 33/131 (25%), Positives = 62/131 (47%), Gaps = 17/131 (12%)
Query: 129 ISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGG 188
+ T+ +S + G+T LA G PD+ ++++ + +A+ + G+ + TV G
Sbjct: 524 VGETIGISEEIMGLTILAAGTSIPDLITSVIV-ARKGLGDMAVSSSVGSNIFDITV---G 579
Query: 189 I-------TILH---PFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYL--GL 236
+ T++H P +S F IV + + L + + + LG++ GL
Sbjct: 580 LPLPWLLYTVIHRFQPVAVSSNGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGL 639
Query: 237 Y-VFYVVTVIL 246
Y VF VV+V+L
Sbjct: 640 YFVFLVVSVLL 650
>gi|29788987 solute carrier family 24 member 4 isoform 3 [Homo
sapiens]
Length = 558
Score = 76.6 bits (187), Expect = 6e-14
Identities = 49/160 (30%), Positives = 86/160 (53%), Gaps = 4/160 (2%)
Query: 421 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR 480
F + F+T+ LWI + +V ++ +G + + ++G+T LA G S+ D + +AR
Sbjct: 388 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 447
Query: 481 QGYPRMAFSACFGGIIFNILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSL 538
QG MA S G +F+ILVG+G+ G + + VK+ G LV+ + LG S+
Sbjct: 448 QGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG-LVYSVVLLLG-SV 505
Query: 539 VFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGV 578
+++ + L ++L R G +L+ Y FL +++ EF V
Sbjct: 506 ALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNV 545
Score = 68.9 bits (167), Expect = 1e-11
Identities = 41/146 (28%), Positives = 73/146 (50%), Gaps = 3/146 (2%)
Query: 99 AVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSAL 158
AV L++ LY+F L + FF P+L I L LS +VAG TF+A G+ P++F+++
Sbjct: 35 AVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASV 94
Query: 159 VAFSDPHTAGLALGALFGAGVLVTTVVAG--GITILHPFMAASRPFFRDIVFYMVAVFLT 216
+ H + +G + G+ V + G G+ RD V+Y ++V +
Sbjct: 95 IGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVL 153
Query: 217 FLMLFRGRVTLAWALGYLGLYVFYVV 242
+ ++ ++ L + LYVFY++
Sbjct: 154 IVFIYDEQIVWWEGLVLIILYVFYIL 179
Score = 37.7 bits (86), Expect = 0.029
Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 31/162 (19%)
Query: 98 LAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSA 157
+ TL+++ Y+ + L ++ I TL + + G+TFLA G PD ++
Sbjct: 394 ITATLWIAVFSYIMVWL-----------VTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 442
Query: 158 LVA-------FSDPHTAGL-ALGALFGAGV---LVTTVVAGGITILHPFMAASRPFFRDI 206
L+ + +T G L G GV L T VV G T+ SR +
Sbjct: 443 LIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTV----KINSRGLVYSV 498
Query: 207 VFYMVAVFLTFLMLFRGRVTLAWALG-YLGLYVFYVVTVILC 247
V + +V LT L + + W L LG+YV + + LC
Sbjct: 499 VLLLGSVALTVLGIHLNK----WRLDRKLGVYVLVLYAIFLC 536
Score = 33.5 bits (75), Expect = 0.56
Identities = 41/171 (23%), Positives = 64/171 (37%), Gaps = 26/171 (15%)
Query: 309 LNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPL 368
L+P + R W VF P+ FLL +T+P N +P +++ +
Sbjct: 348 LSPFSVPEARGDKVKW----VFTWPLIFLLCVTIP---------NCSKPRWEKFFMVTFI 394
Query: 369 VVVLTLQSGTYGVYEIGGLVPVWVVVVIAGT-----ALASVTFFATSDSQPPRLHWLFAF 423
L + +Y + VW+V +I T + +TF A S P + L
Sbjct: 395 TATLWIAVFSY--------IMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 446
Query: 424 LGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFS 474
L N + V +IL LGV + L V+ NS G +S
Sbjct: 447 RQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYS 497
>gi|24111228 solute carrier family 24 member 4 isoform 1 precursor
[Homo sapiens]
Length = 605
Score = 76.6 bits (187), Expect = 6e-14
Identities = 49/160 (30%), Positives = 86/160 (53%), Gaps = 4/160 (2%)
Query: 421 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR 480
F + F+T+ LWI + +V ++ +G + + ++G+T LA G S+ D + +AR
Sbjct: 435 FFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVAR 494
Query: 481 QGYPRMAFSACFGGIIFNILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSL 538
QG MA S G +F+ILVG+G+ G + + VK+ G LV+ + LG S+
Sbjct: 495 QGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRG-LVYSVVLLLG-SV 552
Query: 539 VFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGV 578
+++ + L ++L R G +L+ Y FL +++ EF V
Sbjct: 553 ALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNV 592
Score = 68.9 bits (167), Expect = 1e-11
Identities = 41/146 (28%), Positives = 73/146 (50%), Gaps = 3/146 (2%)
Query: 99 AVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSAL 158
AV L++ LY+F L + FF P+L I L LS +VAG TF+A G+ P++F+++
Sbjct: 82 AVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASV 141
Query: 159 VAFSDPHTAGLALGALFGAGVLVTTVVAG--GITILHPFMAASRPFFRDIVFYMVAVFLT 216
+ H + +G + G+ V + G G+ RD V+Y ++V +
Sbjct: 142 IGVFITH-GDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVL 200
Query: 217 FLMLFRGRVTLAWALGYLGLYVFYVV 242
+ ++ ++ L + LYVFY++
Sbjct: 201 IVFIYDEQIVWWEGLVLIILYVFYIL 226
Score = 37.7 bits (86), Expect = 0.029
Identities = 43/162 (26%), Positives = 68/162 (41%), Gaps = 31/162 (19%)
Query: 98 LAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSA 157
+ TL+++ Y+ + L ++ I TL + + G+TFLA G PD ++
Sbjct: 441 ITATLWIAVFSYIMVWL-----------VTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 489
Query: 158 LVA-------FSDPHTAGL-ALGALFGAGV---LVTTVVAGGITILHPFMAASRPFFRDI 206
L+ + +T G L G GV L T VV G T+ SR +
Sbjct: 490 LIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTV----KINSRGLVYSV 545
Query: 207 VFYMVAVFLTFLMLFRGRVTLAWALG-YLGLYVFYVVTVILC 247
V + +V LT L + + W L LG+YV + + LC
Sbjct: 546 VLLLGSVALTVLGIHLNK----WRLDRKLGVYVLVLYAIFLC 583
Score = 33.5 bits (75), Expect = 0.56
Identities = 41/171 (23%), Positives = 64/171 (37%), Gaps = 26/171 (15%)
Query: 309 LNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPL 368
L+P + R W VF P+ FLL +T+P N +P +++ +
Sbjct: 395 LSPFSVPEARGDKVKW----VFTWPLIFLLCVTIP---------NCSKPRWEKFFMVTFI 441
Query: 369 VVVLTLQSGTYGVYEIGGLVPVWVVVVIAGT-----ALASVTFFATSDSQPPRLHWLFAF 423
L + +Y + VW+V +I T + +TF A S P + L
Sbjct: 442 TATLWIAVFSY--------IMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 493
Query: 424 LGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFS 474
L N + V +IL LGV + L V+ NS G +S
Sbjct: 494 RQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYS 544
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 37.0 bits (84), Expect = 0.050
Identities = 40/167 (23%), Positives = 70/167 (41%), Gaps = 32/167 (19%)
Query: 110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGL 169
L ++G A+ F C T+ L +V V F+A G PD F++ VA A
Sbjct: 762 LTALIGDLASHFGC--------TVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADA 813
Query: 170 ALGALFGA---GVLVTTVVAGGITILHPFMAASRPF--------FRDIVFYMVAVFLTFL 218
++G + G+ V + VA + ++ + RPF F +F + A +
Sbjct: 814 SIGNVTGSNAVNVFLGLGVAWSVAAVY-WAVQGRPFEVRTGTLAFSVTLFTVFAFVGIAV 872
Query: 219 MLFRGRVTLAWALG------------YLGLYVFYVVTVILCTWIYQR 253
+L+R R + LG +LGL++ Y++ L + + R
Sbjct: 873 LLYRRRPHIGGELGGPRGPKLATTALFLGLWLLYILFASLEAYCHIR 919
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 36.6 bits (83), Expect = 0.066
Identities = 37/157 (23%), Positives = 68/157 (43%), Gaps = 17/157 (10%)
Query: 87 IFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSA-ISTTLKLSHNVAGVTFL 145
+F PP+ + W ++ IL + F +L++ T+ L +V V F+
Sbjct: 788 LFAFVPPT------EYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFV 841
Query: 146 AFGNGAPDIFSALVAFSDPHTAGLALGALFGA-GVLVTTVVAGGITILHPFMAASRPFFR 204
A G PD F++ VA + A ++G + G+ V V + +I + AA+ F+
Sbjct: 842 ALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFK 901
Query: 205 ---DIVFYMVAVFLTF------LMLFRGRVTLAWALG 232
+ + V +F F ++L+R R + LG
Sbjct: 902 VSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELG 938
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 36.6 bits (83), Expect = 0.066
Identities = 37/157 (23%), Positives = 68/157 (43%), Gaps = 17/157 (10%)
Query: 87 IFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSA-ISTTLKLSHNVAGVTFL 145
+F PP+ + W ++ IL + F +L++ T+ L +V V F+
Sbjct: 752 LFAFVPPT------EYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFV 805
Query: 146 AFGNGAPDIFSALVAFSDPHTAGLALGALFGA-GVLVTTVVAGGITILHPFMAASRPFFR 204
A G PD F++ VA + A ++G + G+ V V + +I + AA+ F+
Sbjct: 806 ALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFK 865
Query: 205 ---DIVFYMVAVFLTF------LMLFRGRVTLAWALG 232
+ + V +F F ++L+R R + LG
Sbjct: 866 VSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELG 902
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 36.6 bits (83), Expect = 0.066
Identities = 37/157 (23%), Positives = 68/157 (43%), Gaps = 17/157 (10%)
Query: 87 IFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSA-ISTTLKLSHNVAGVTFL 145
+F PP+ + W ++ IL + F +L++ T+ L +V V F+
Sbjct: 775 LFAFVPPT------EYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFV 828
Query: 146 AFGNGAPDIFSALVAFSDPHTAGLALGALFGA-GVLVTTVVAGGITILHPFMAASRPFFR 204
A G PD F++ VA + A ++G + G+ V V + +I + AA+ F+
Sbjct: 829 ALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFK 888
Query: 205 ---DIVFYMVAVFLTF------LMLFRGRVTLAWALG 232
+ + V +F F ++L+R R + LG
Sbjct: 889 VSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELG 925
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 36.6 bits (83), Expect = 0.066
Identities = 37/157 (23%), Positives = 68/157 (43%), Gaps = 17/157 (10%)
Query: 87 IFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSA-ISTTLKLSHNVAGVTFL 145
+F PP+ + W ++ IL + F +L++ T+ L +V V F+
Sbjct: 783 LFAFVPPT------EYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFV 836
Query: 146 AFGNGAPDIFSALVAFSDPHTAGLALGALFGA-GVLVTTVVAGGITILHPFMAASRPFFR 204
A G PD F++ VA + A ++G + G+ V V + +I + AA+ F+
Sbjct: 837 ALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFK 896
Query: 205 ---DIVFYMVAVFLTF------LMLFRGRVTLAWALG 232
+ + V +F F ++L+R R + LG
Sbjct: 897 VSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELG 933
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 34.3 bits (77), Expect = 0.33
Identities = 37/164 (22%), Positives = 67/164 (40%), Gaps = 30/164 (18%)
Query: 110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGL 169
L I+G A+ F C T+ L +V V F+AFG PD F++ A A
Sbjct: 765 LTAIIGDLASHFGC--------TIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADA 816
Query: 170 ALGALFGA---GVLVTTVVAGGITILH-------PFMAASRPFFRDIVFYMVAVFLTFLM 219
++G + G+ V + +A + ++ ++A F +F + A ++
Sbjct: 817 SIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVL 876
Query: 220 LFRGRVTLAWALG------------YLGLYVFYVVTVILCTWIY 251
L+R R L LG ++ L++ Y++ L + Y
Sbjct: 877 LYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY 920
Score = 32.0 bits (71), Expect = 1.6
Identities = 21/92 (22%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 415 PRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFS 474
P + + F S L I + ++ G L ++V + +A+G S+ D F+
Sbjct: 744 PPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFA 803
Query: 475 DFTLARQG-YPRMAFSACFGGIIFNILVGVGL 505
A Q Y + G N+ +G+GL
Sbjct: 804 SKAAALQDVYADASIGNVTGSNAVNVFLGIGL 835
>gi|33946308 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform F [Homo sapiens]
Length = 284
Score = 34.3 bits (77), Expect = 0.33
Identities = 37/164 (22%), Positives = 67/164 (40%), Gaps = 30/164 (18%)
Query: 110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGL 169
L I+G A+ F C T+ L +V V F+AFG PD F++ A A
Sbjct: 125 LTAIIGDLASHFGC--------TIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADA 176
Query: 170 ALGALFGA---GVLVTTVVAGGITILH-------PFMAASRPFFRDIVFYMVAVFLTFLM 219
++G + G+ V + +A + ++ ++A F +F + A ++
Sbjct: 177 SIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVL 236
Query: 220 LFRGRVTLAWALG------------YLGLYVFYVVTVILCTWIY 251
L+R R L LG ++ L++ Y++ L + Y
Sbjct: 237 LYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY 280
Score = 32.0 bits (71), Expect = 1.6
Identities = 21/92 (22%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 415 PRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFS 474
P + + F S L I + ++ G L ++V + +A+G S+ D F+
Sbjct: 104 PPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFA 163
Query: 475 DFTLARQG-YPRMAFSACFGGIIFNILVGVGL 505
A Q Y + G N+ +G+GL
Sbjct: 164 SKAAALQDVYADASIGNVTGSNAVNVFLGIGL 195
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 34.3 bits (77), Expect = 0.33
Identities = 37/164 (22%), Positives = 67/164 (40%), Gaps = 30/164 (18%)
Query: 110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGL 169
L I+G A+ F C T+ L +V V F+AFG PD F++ A A
Sbjct: 762 LTAIIGDLASHFGC--------TIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADA 813
Query: 170 ALGALFGA---GVLVTTVVAGGITILH-------PFMAASRPFFRDIVFYMVAVFLTFLM 219
++G + G+ V + +A + ++ ++A F +F + A ++
Sbjct: 814 SIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVL 873
Query: 220 LFRGRVTLAWALG------------YLGLYVFYVVTVILCTWIY 251
L+R R L LG ++ L++ Y++ L + Y
Sbjct: 874 LYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY 917
Score = 32.0 bits (71), Expect = 1.6
Identities = 21/92 (22%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 415 PRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFS 474
P + + F S L I + ++ G L ++V + +A+G S+ D F+
Sbjct: 741 PPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFA 800
Query: 475 DFTLARQG-YPRMAFSACFGGIIFNILVGVGL 505
A Q Y + G N+ +G+GL
Sbjct: 801 SKAAALQDVYADASIGNVTGSNAVNVFLGIGL 832
>gi|194354001 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform G [Homo sapiens]
Length = 298
Score = 34.3 bits (77), Expect = 0.33
Identities = 37/164 (22%), Positives = 67/164 (40%), Gaps = 30/164 (18%)
Query: 110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGL 169
L I+G A+ F C T+ L +V V F+AFG PD F++ A A
Sbjct: 139 LTAIIGDLASHFGC--------TIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADA 190
Query: 170 ALGALFGA---GVLVTTVVAGGITILH-------PFMAASRPFFRDIVFYMVAVFLTFLM 219
++G + G+ V + +A + ++ ++A F +F + A ++
Sbjct: 191 SIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVL 250
Query: 220 LFRGRVTLAWALG------------YLGLYVFYVVTVILCTWIY 251
L+R R L LG ++ L++ Y++ L + Y
Sbjct: 251 LYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY 294
Score = 32.0 bits (71), Expect = 1.6
Identities = 21/92 (22%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 415 PRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFS 474
P + + F S L I + ++ G L ++V + +A+G S+ D F+
Sbjct: 118 PPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFA 177
Query: 475 DFTLARQG-YPRMAFSACFGGIIFNILVGVGL 505
A Q Y + G N+ +G+GL
Sbjct: 178 SKAAALQDVYADASIGNVTGSNAVNVFLGIGL 209
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 34.3 bits (77), Expect = 0.33
Identities = 37/164 (22%), Positives = 67/164 (40%), Gaps = 30/164 (18%)
Query: 110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGL 169
L I+G A+ F C T+ L +V V F+AFG PD F++ A A
Sbjct: 766 LTAIIGDLASHFGC--------TIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADA 817
Query: 170 ALGALFGA---GVLVTTVVAGGITILH-------PFMAASRPFFRDIVFYMVAVFLTFLM 219
++G + G+ V + +A + ++ ++A F +F + A ++
Sbjct: 818 SIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVL 877
Query: 220 LFRGRVTLAWALG------------YLGLYVFYVVTVILCTWIY 251
L+R R L LG ++ L++ Y++ L + Y
Sbjct: 878 LYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY 921
Score = 32.0 bits (71), Expect = 1.6
Identities = 21/92 (22%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 415 PRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFS 474
P + + F S L I + ++ G L ++V + +A+G S+ D F+
Sbjct: 745 PPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFA 804
Query: 475 DFTLARQG-YPRMAFSACFGGIIFNILVGVGL 505
A Q Y + G N+ +G+GL
Sbjct: 805 SKAAALQDVYADASIGNVTGSNAVNVFLGIGL 836
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 34.3 bits (77), Expect = 0.33
Identities = 37/164 (22%), Positives = 67/164 (40%), Gaps = 30/164 (18%)
Query: 110 LFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGL 169
L I+G A+ F C T+ L +V V F+AFG PD F++ A A
Sbjct: 768 LTAIIGDLASHFGC--------TIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADA 819
Query: 170 ALGALFGA---GVLVTTVVAGGITILH-------PFMAASRPFFRDIVFYMVAVFLTFLM 219
++G + G+ V + +A + ++ ++A F +F + A ++
Sbjct: 820 SIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVL 879
Query: 220 LFRGRVTLAWALG------------YLGLYVFYVVTVILCTWIY 251
L+R R L LG ++ L++ Y++ L + Y
Sbjct: 880 LYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCY 923
Score = 32.0 bits (71), Expect = 1.6
Identities = 21/92 (22%), Positives = 37/92 (40%), Gaps = 1/92 (1%)
Query: 415 PRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFS 474
P + + F S L I + ++ G L ++V + +A+G S+ D F+
Sbjct: 747 PPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFA 806
Query: 475 DFTLARQG-YPRMAFSACFGGIIFNILVGVGL 505
A Q Y + G N+ +G+GL
Sbjct: 807 SKAAALQDVYADASIGNVTGSNAVNVFLGIGL 838
>gi|94721340 SID1 transmembrane family, member 2 [Homo sapiens]
Length = 832
Score = 34.3 bits (77), Expect = 0.33
Identities = 22/62 (35%), Positives = 34/62 (54%), Gaps = 9/62 (14%)
Query: 234 LGLYV-FYVVTVILCTWIYQRQRRGSLF------CPMPVTPEILSDSEEDRVSSNTNSYD 286
LG+++ FY++TV+L W RQ++ +L CP P +L+DS SS Y+
Sbjct: 301 LGIFLSFYLLTVLLACWENWRQKKKTLLVAIDRACPESGHPRVLADSFPG--SSPYEGYN 358
Query: 287 YG 288
YG
Sbjct: 359 YG 360
>gi|5453613 CD7 antigen precursor [Homo sapiens]
Length = 240
Score = 32.0 bits (71), Expect = 1.6
Identities = 23/81 (28%), Positives = 36/81 (44%), Gaps = 6/81 (7%)
Query: 145 LAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFR 204
LA G P +A PH + +GA V +T +GG+ ++ +P +
Sbjct: 14 LALARGLPGALAAQEVQQSPHCTTVPVGA----SVNITCSTSGGLRGIYLRQLGPQP--Q 67
Query: 205 DIVFYMVAVFLTFLMLFRGRV 225
DI++Y V T FRGR+
Sbjct: 68 DIIYYEDGVVPTTDRRFRGRI 88
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 31.6 bits (70), Expect = 2.1
Identities = 38/131 (29%), Positives = 55/131 (41%), Gaps = 28/131 (21%)
Query: 29 GSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTN-PDCHSDGGYLDYLEGI 87
GS+T + + P +N P CR + G N C F T+ P C GY G
Sbjct: 4362 GSTTECDAAIELP---INLPP--PCRCMHGGN----CYFDETDLPKCKCPSGYT----GK 4408
Query: 88 FCH--FPPSLLPLAVTLYVSWLLYLFLILGVTA-AKFF-----------CPNLSAISTTL 133
+C F + P + V + L +++G A A FF P L ++S+ +
Sbjct: 4409 YCEMAFSKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYRRTGSLLPALPKLPSLSSLV 4468
Query: 134 KLSHNVAGVTF 144
K S N GVTF
Sbjct: 4469 KPSENGNGVTF 4479
>gi|72534746 tetraspanin 18 isoform 1 [Homo sapiens]
Length = 267
Score = 30.4 bits (67), Expect = 4.7
Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 10/87 (11%)
Query: 496 IFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRV 555
+FN + +G CLL I V ++P G V A L L+ + L+++ F L +
Sbjct: 15 VFNFFIFLGGACLLAIG---IWVMVDPTGFREIVAANPLLLTGAYILLAMGGLLFLLGFL 71
Query: 556 -------YGFCLLLFYLNFLVVALLTE 575
CLLLF+ F+++ L E
Sbjct: 72 GCCGAVRENKCLLLFFFLFILIIFLAE 98
>gi|42476204 tetraspanin 18 isoform 2 [Homo sapiens]
Length = 248
Score = 30.4 bits (67), Expect = 4.7
Identities = 25/87 (28%), Positives = 40/87 (45%), Gaps = 10/87 (11%)
Query: 496 IFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRV 555
+FN + +G CLL I V ++P G V A L L+ + L+++ F L +
Sbjct: 15 VFNFFIFLGGACLLAIG---IWVMVDPTGFREIVAANPLLLTGAYILLAMGGLLFLLGFL 71
Query: 556 -------YGFCLLLFYLNFLVVALLTE 575
CLLLF+ F+++ L E
Sbjct: 72 GCCGAVRENKCLLLFFFLFILIIFLAE 98
>gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens]
Length = 2459
Score = 30.4 bits (67), Expect = 4.7
Identities = 36/138 (26%), Positives = 60/138 (43%), Gaps = 16/138 (11%)
Query: 99 AVTLYVSWLLYLFLILGVTAAK----FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDI 154
A +Y +LLY ++ G +K +FC + + + L+ A F+ A
Sbjct: 2189 AELIYFLFLLYYMVVQGKRMSKETWGYFCSKWNLLELAIILASWSALAVFVKRAVLAERD 2248
Query: 155 FSAL-------VAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFM----AASRPFF 203
++FS+ A ALG + VL++TV + L+P M AA R +
Sbjct: 2249 LQRCRNHREEGISFSETAAADAALGYIIAFLVLLSTVKLWHLLRLNPKMNMITAALRRAW 2308
Query: 204 RDIVFYMVAVFLTFLMLF 221
DI +M+ V LT L+ +
Sbjct: 2309 GDISGFMI-VILTMLLAY 2325
>gi|4755125 aquaporin 4 isoform b [Homo sapiens]
Length = 301
Score = 30.0 bits (66), Expect = 6.1
Identities = 24/84 (28%), Positives = 40/84 (47%), Gaps = 9/84 (10%)
Query: 159 VAFSDPHTAGLALGALFGAGVLV----TTVVAG-GITILHPFMAASRPFFRDIVFYMVAV 213
+A S + A LGA+ GAG+L +VV G G+T++H + A +++ V
Sbjct: 90 IAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLV 149
Query: 214 FLTFLMLFRGRV----TLAWALGY 233
F F R ++A A+G+
Sbjct: 150 FTIFASCDSKRTDVTGSIALAIGF 173
>gi|4502181 aquaporin 4 isoform a [Homo sapiens]
Length = 323
Score = 30.0 bits (66), Expect = 6.1
Identities = 24/84 (28%), Positives = 40/84 (47%), Gaps = 9/84 (10%)
Query: 159 VAFSDPHTAGLALGALFGAGVLV----TTVVAG-GITILHPFMAASRPFFRDIVFYMVAV 213
+A S + A LGA+ GAG+L +VV G G+T++H + A +++ V
Sbjct: 112 IAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLV 171
Query: 214 FLTFLMLFRGRV----TLAWALGY 233
F F R ++A A+G+
Sbjct: 172 FTIFASCDSKRTDVTGSIALAIGF 195
>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
Length = 1044
Score = 30.0 bits (66), Expect = 6.1
Identities = 31/138 (22%), Positives = 61/138 (44%), Gaps = 8/138 (5%)
Query: 424 LGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGY 483
L +T A+W + + E V R + L + N +G A + R+
Sbjct: 732 LAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNVVG-ALGECCQEREN- 789
Query: 484 PRMAFSACFGGI--IFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFS 541
R+ C GGI + N+LVG+ L+ ++++ +EP+ ++ ++ G+ L++S
Sbjct: 790 -RVIVRKC-GGIQPLVNLLVGINQALLVNVTKAVGACAVEPESMM--IIDRLDGVRLLWS 845
Query: 542 LVSVPLQCFQLSRVYGFC 559
L+ P + S + C
Sbjct: 846 LLKNPHPDVKASAAWALC 863
>gi|29725635 otopetrin 1 [Homo sapiens]
Length = 612
Score = 29.6 bits (65), Expect = 8.0
Identities = 15/52 (28%), Positives = 28/52 (53%)
Query: 168 GLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLM 219
G+ +GA+ G VL T+ + ++H + ++ I+FY+ A+ L LM
Sbjct: 310 GVMVGAVLGLTVLAATIAVVVVYLIHIGRSKTKSESALIMFYLYAITLLMLM 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.143 0.451
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,404,427
Number of Sequences: 37866
Number of extensions: 935115
Number of successful extensions: 2547
Number of sequences better than 10.0: 29
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2489
Number of HSP's gapped (non-prelim): 56
length of query: 584
length of database: 18,247,518
effective HSP length: 108
effective length of query: 476
effective length of database: 14,157,990
effective search space: 6739203240
effective search space used: 6739203240
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.