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Search of human proteins with 39995059
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
(452 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 929 0.0
gi|39995061 caspase 2 isoform 3 [Homo sapiens] 212 5e-55
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 148 9e-36
gi|15718698 caspase 7 isoform delta [Homo sapiens] 125 1e-28
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 125 1e-28
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 125 1e-28
gi|14790115 caspase 3 preproprotein [Homo sapiens] 124 2e-28
gi|14790119 caspase 3 preproprotein [Homo sapiens] 124 2e-28
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 119 4e-27
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 119 7e-27
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 119 7e-27
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 119 7e-27
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 119 7e-27
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 119 7e-27
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 115 1e-25
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 115 1e-25
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 110 3e-24
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 110 3e-24
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 110 3e-24
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 110 3e-24
gi|6912286 caspase 14 precursor [Homo sapiens] 107 2e-23
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 98 2e-20
gi|209870073 caspase 5 isoform c [Homo sapiens] 98 2e-20
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 98 2e-20
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 98 2e-20
gi|15431332 caspase 1 isoform delta [Homo sapiens] 96 5e-20
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 95 1e-19
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 95 1e-19
gi|209870075 caspase 5 isoform d [Homo sapiens] 89 1e-17
gi|14916485 caspase 6 isoform beta [Homo sapiens] 83 4e-16
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 929 bits (2401), Expect = 0.0
Identities = 452/452 (100%), Positives = 452/452 (100%)
Query: 1 MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL 60
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL
Sbjct: 1 MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL 60
Query: 61 LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT 120
LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT
Sbjct: 61 LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLT 120
Query: 121 TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT 180
TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT
Sbjct: 121 TLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCT 180
Query: 181 PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV 240
PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV
Sbjct: 181 PEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDV 240
Query: 241 HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF 300
HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF
Sbjct: 241 HVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLF 300
Query: 301 DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT 360
DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT
Sbjct: 301 DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPT 360
Query: 361 RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY 420
RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY
Sbjct: 361 RSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGY 420
Query: 421 APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT 452
APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
Sbjct: 421 APGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT 452
>gi|39995061 caspase 2 isoform 3 [Homo sapiens]
Length = 108
Score = 212 bits (540), Expect = 5e-55
Identities = 106/106 (100%), Positives = 106/106 (100%)
Query: 1 MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL 60
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL
Sbjct: 1 MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHL 60
Query: 61 LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEAL 106
LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEAL
Sbjct: 61 LEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEAL 106
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 148 bits (374), Expect = 9e-36
Identities = 119/391 (30%), Positives = 180/391 (46%), Gaps = 32/391 (8%)
Query: 40 LKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNL---LPKRGP 96
L++ R+ L ++L + +L + LL +++ M E IQ + GS S+ + L L RG
Sbjct: 9 LRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQ-RAGSGSRRDQARQLIIDLETRGS 67
Query: 97 QAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRL 156
QA F L +T Q L L T + P L + L P +K +
Sbjct: 68 QALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLR-------PEIRKPEV 120
Query: 157 STDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKEL 216
+D G E + + LAY L P G L+++NV+F E L
Sbjct: 121 LRPETPRPVDIGSGGFG---DVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGL 177
Query: 217 EFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLS 276
R+G ++D L F L + V V D TA++M L AQ H D C+V +LS
Sbjct: 178 RTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQD-HGALDCCVVVILS 236
Query: 277 HGVE-------GAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGV 329
HG + GA+YG DG + ++++ +F+ +CPSL KPK+FFIQAC G++ D G
Sbjct: 237 HGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGF 296
Query: 330 DQQDGKNHAGSPGCE-ESDA-----GKEKLPKM----RLPTRSDMICGYACLKGTAAMRN 379
+ SPG E DA G ++ LPT SD+ Y+ G + R+
Sbjct: 297 EVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRD 356
Query: 380 TKRGSWYIEALAQVFSERACDMHVADMLVKV 410
K GSWY+E L +F + A + +L++V
Sbjct: 357 PKSGSWYVETLDDIFEQWAHSEDLQSLLLRV 387
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 125 bits (313), Expect = 1e-28
Identities = 77/255 (30%), Positives = 128/255 (50%), Gaps = 16/255 (6%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251
Y + G ++++N +F + R+G D D L F+ LG+DV V D + +M
Sbjct: 93 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 152
Query: 252 QEKLQNFAQLP-AHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQN 310
Q+ L+ ++ + +CI LLSHG E IYG DG + ++++ F C +L
Sbjct: 153 QDLLKKASEEDHTNAACFACI--LLSHGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLE 209
Query: 311 KPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
KPK+FFIQACRG E D G+ G ++DA P+ ++P +D + Y+
Sbjct: 210 KPKLFFIQACRGTELDDGIQADSGP-------INDTDAN----PRYKIPVEADFLFAYST 258
Query: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVN-ALIKDREGYAPGTEFHRC 429
+ G + R+ RGSW+++AL + E D+ + +L +VN + + E + FH
Sbjct: 259 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 318
Query: 430 KEMSEYCSTLCRHLY 444
K++ S L + LY
Sbjct: 319 KQIPCVVSMLTKELY 333
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 125 bits (313), Expect = 1e-28
Identities = 77/255 (30%), Positives = 128/255 (50%), Gaps = 16/255 (6%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251
Y + G ++++N +F + R+G D D L F+ LG+DV V D + +M
Sbjct: 60 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
Query: 252 QEKLQNFAQLP-AHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQN 310
Q+ L+ ++ + +CI LLSHG E IYG DG + ++++ F C +L
Sbjct: 120 QDLLKKASEEDHTNAACFACI--LLSHGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLE 176
Query: 311 KPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
KPK+FFIQACRG E D G+ G ++DA P+ ++P +D + Y+
Sbjct: 177 KPKLFFIQACRGTELDDGIQADSGP-------INDTDAN----PRYKIPVEADFLFAYST 225
Query: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVN-ALIKDREGYAPGTEFHRC 429
+ G + R+ RGSW+++AL + E D+ + +L +VN + + E + FH
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 285
Query: 430 KEMSEYCSTLCRHLY 444
K++ S L + LY
Sbjct: 286 KQIPCVVSMLTKELY 300
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 125 bits (313), Expect = 1e-28
Identities = 77/255 (30%), Positives = 128/255 (50%), Gaps = 16/255 (6%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251
Y + G ++++N +F + R+G D D L F+ LG+DV V D + +M
Sbjct: 60 YNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKM 119
Query: 252 QEKLQNFAQLP-AHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQN 310
Q+ L+ ++ + +CI LLSHG E IYG DG + ++++ F C +L
Sbjct: 120 QDLLKKASEEDHTNAACFACI--LLSHGEENVIYGKDG-VTPIKDLTAHFRGDRCKTLLE 176
Query: 311 KPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
KPK+FFIQACRG E D G+ G ++DA P+ ++P +D + Y+
Sbjct: 177 KPKLFFIQACRGTELDDGIQADSGP-------INDTDAN----PRYKIPVEADFLFAYST 225
Query: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVN-ALIKDREGYAPGTEFHRC 429
+ G + R+ RGSW+++AL + E D+ + +L +VN + + E + FH
Sbjct: 226 VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEK 285
Query: 430 KEMSEYCSTLCRHLY 444
K++ S L + LY
Sbjct: 286 KQIPCVVSMLTKELY 300
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 124 bits (310), Expect = 2e-28
Identities = 75/257 (29%), Positives = 130/257 (50%), Gaps = 17/257 (6%)
Query: 191 AYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQE 250
+Y++ GL ++++N +F + RSG DVD + L F+ L Y+V D T +E
Sbjct: 36 SYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREE 95
Query: 251 MQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQN 310
+ E +++ ++ H S + LLSHG EG I+G +G + L+++ F C SL
Sbjct: 96 IVELMRDVSK-EDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKKITNFFRGDRCRSLTG 153
Query: 311 KPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
KPK+F IQACRG E D G++ G + + + ++P +D + Y+
Sbjct: 154 KPKLFIIQACRGTELDCGIETDSGVD--------------DDMACHKIPVEADFLYAYST 199
Query: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALI-KDREGYAPGTEFHRC 429
G + RN+K GSW+I++L + + A + +L +VN + + E ++ FH
Sbjct: 200 APGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAK 259
Query: 430 KEMSEYCSTLCRHLYLF 446
K++ S L + LY +
Sbjct: 260 KQIPCIVSMLTKELYFY 276
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 124 bits (310), Expect = 2e-28
Identities = 75/257 (29%), Positives = 130/257 (50%), Gaps = 17/257 (6%)
Query: 191 AYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQE 250
+Y++ GL ++++N +F + RSG DVD + L F+ L Y+V D T +E
Sbjct: 36 SYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREE 95
Query: 251 MQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQN 310
+ E +++ ++ H S + LLSHG EG I+G +G + L+++ F C SL
Sbjct: 96 IVELMRDVSK-EDHSKRSSFVCVLLSHGEEGIIFGTNGPV-DLKKITNFFRGDRCRSLTG 153
Query: 311 KPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
KPK+F IQACRG E D G++ G + + + ++P +D + Y+
Sbjct: 154 KPKLFIIQACRGTELDCGIETDSGVD--------------DDMACHKIPVEADFLYAYST 199
Query: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALI-KDREGYAPGTEFHRC 429
G + RN+K GSW+I++L + + A + +L +VN + + E ++ FH
Sbjct: 200 APGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAK 259
Query: 430 KEMSEYCSTLCRHLYLF 446
K++ S L + LY +
Sbjct: 260 KQIPCIVSMLTKELYFY 276
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 119 bits (299), Expect = 4e-27
Identities = 104/354 (29%), Positives = 162/354 (45%), Gaps = 48/354 (13%)
Query: 42 KNRVVLAKQLL--LSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAF 99
+ RV L + LL LSE ++ KD+I L L + ++ S S F
Sbjct: 109 RQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPKTEMTSLS----------------F 152
Query: 100 DAFCEALRETKQGHLEDMLLTTLSGL-QHVLPPLSCDYDLSLPFPVCESCPLYKKLRLST 158
AF E KQG +++ LT L L + V+P L + E K +++ T
Sbjct: 153 LAFLE-----KQGKIDEDNLTCLEDLCKTVVPKLLRNI---------EKYKREKAIQIVT 198
Query: 159 DTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLA-YRLQSRPRGLALVLSNVHFTGEKELE 217
V+ ++ G L + F + + A YR+ RGL ++++N FT K+
Sbjct: 199 PPVDKEAESYQGEEELVSQTDVKTFLEALPRAAVYRMNRNHRGLCVIVNNHSFTSLKD-- 256
Query: 218 FRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSH 277
R G D L +F+ LG+ VH+ + T EM+ LQ PAH D + +L+H
Sbjct: 257 -RQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTH 315
Query: 278 GVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVD-QQDGKN 336
G GA+Y D L+ ++E+ F CP L KPK+FFIQAC+G+E V + D N
Sbjct: 316 GRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALN 375
Query: 337 HAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEAL 390
+P + +P +D + G A + G + R+ + GSWYI++L
Sbjct: 376 PEQAPTSLQDS----------IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSL 419
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 119 bits (297), Expect = 7e-27
Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244
Y+++S+PRG L+++N +F +E + R+G +D L T F+ L +++
Sbjct: 285 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 344
Query: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304
D T +++ E L+ + QL H D I +LSHG +G IYG DG+ + E+ F
Sbjct: 345 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 403
Query: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363
CPSL KPK+FFIQAC+GD +G+ + + S P+ R +P +D
Sbjct: 404 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 457
Query: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418
+ G A + + RN G+WYI++L Q ER C + +L +VN + +++
Sbjct: 458 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 513
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 119 bits (297), Expect = 7e-27
Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244
Y+++S+PRG L+++N +F +E + R+G +D L T F+ L +++
Sbjct: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Query: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304
D T +++ E L+ + QL H D I +LSHG +G IYG DG+ + E+ F
Sbjct: 271 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 329
Query: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363
CPSL KPK+FFIQAC+GD +G+ + + S P+ R +P +D
Sbjct: 330 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 383
Query: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418
+ G A + + RN G+WYI++L Q ER C + +L +VN + +++
Sbjct: 384 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 439
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 119 bits (297), Expect = 7e-27
Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244
Y+++S+PRG L+++N +F +E + R+G +D L T F+ L +++
Sbjct: 211 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 270
Query: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304
D T +++ E L+ + QL H D I +LSHG +G IYG DG+ + E+ F
Sbjct: 271 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 329
Query: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363
CPSL KPK+FFIQAC+GD +G+ + + S P+ R +P +D
Sbjct: 330 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 383
Query: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418
+ G A + + RN G+WYI++L Q ER C + +L +VN + +++
Sbjct: 384 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 439
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 119 bits (297), Expect = 7e-27
Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244
Y+++S+PRG L+++N +F +E + R+G +D L T F+ L +++
Sbjct: 226 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 285
Query: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304
D T +++ E L+ + QL H D I +LSHG +G IYG DG+ + E+ F
Sbjct: 286 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 344
Query: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363
CPSL KPK+FFIQAC+GD +G+ + + S P+ R +P +D
Sbjct: 345 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 398
Query: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418
+ G A + + RN G+WYI++L Q ER C + +L +VN + +++
Sbjct: 399 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 454
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 119 bits (297), Expect = 7e-27
Identities = 74/237 (31%), Positives = 122/237 (51%), Gaps = 18/237 (7%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKE-------LEFRSGGDVDHSTLVTLFKLLGYDVHVLC 244
Y+++S+PRG L+++N +F +E + R+G +D L T F+ L +++
Sbjct: 243 YQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHD 302
Query: 245 DQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNAN 304
D T +++ E L+ + QL H D I +LSHG +G IYG DG+ + E+ F
Sbjct: 303 DCTVEQIYEILKIY-QLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLK 361
Query: 305 CPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMR-LPTRSD 363
CPSL KPK+FFIQAC+GD +G+ + + S P+ R +P +D
Sbjct: 362 CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSS------PQTRYIPDEAD 415
Query: 364 MICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDM--HVADMLVKVNALIKDRE 418
+ G A + + RN G+WYI++L Q ER C + +L +VN + +++
Sbjct: 416 FLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRER-CPRGDDILTILTEVNYEVSNKD 471
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 115 bits (287), Expect = 1e-25
Identities = 67/200 (33%), Positives = 102/200 (51%), Gaps = 14/200 (7%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251
YR+ RGL ++++N FT K+ R G D L +F+ LG+ VH+ + T EM
Sbjct: 276 YRMNRNHRGLCVIVNNHSFTSLKD---RQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 252 QEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNK 311
+ LQ PAH D + +L+HG GA+Y D L+ ++E+ F CP L K
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 392
Query: 312 PKMFFIQACRGDETDRGVD-QQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
PK+FFIQAC+G+E V + D N +P + +P +D + G A
Sbjct: 393 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS----------IPAEADFLLGLAT 442
Query: 371 LKGTAAMRNTKRGSWYIEAL 390
+ G + R+ + GSWYI++L
Sbjct: 443 VPGYVSFRHVEEGSWYIQSL 462
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 115 bits (287), Expect = 1e-25
Identities = 67/200 (33%), Positives = 102/200 (51%), Gaps = 14/200 (7%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251
YR+ RGL ++++N FT K+ R G D L +F+ LG+ VH+ + T EM
Sbjct: 276 YRMNRNHRGLCVIVNNHSFTSLKD---RQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEM 332
Query: 252 QEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNK 311
+ LQ PAH D + +L+HG GA+Y D L+ ++E+ F CP L K
Sbjct: 333 EMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEK 392
Query: 312 PKMFFIQACRGDETDRGVD-QQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
PK+FFIQAC+G+E V + D N +P + +P +D + G A
Sbjct: 393 PKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDS----------IPAEADFLLGLAT 442
Query: 371 LKGTAAMRNTKRGSWYIEAL 390
+ G + R+ + GSWYI++L
Sbjct: 443 VPGYVSFRHVEEGSWYIQSL 462
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 110 bits (275), Expect = 3e-24
Identities = 84/263 (31%), Positives = 120/263 (45%), Gaps = 27/263 (10%)
Query: 196 SRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKL 255
SR R LAL++ N F + R+G +VD + + L + LGY V V + TA +M +L
Sbjct: 67 SRTR-LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTEL 122
Query: 256 QNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQN 310
+ FA P H+ +DS + +SHG+ I G +LQL +F + + NCPSL++
Sbjct: 123 EAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKD 182
Query: 311 KPKMFFIQACRGDETDRGV----DQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMIC 366
KPK+ IQACRGD GV D + P EE + K + D I
Sbjct: 183 KPKVIIIQACRGDSP--GVVWFKDSVGVSGNLSLPTTEEFEDDAIK----KAHIEKDFIA 236
Query: 367 GYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEF 426
+ + R+ GS +I L + E AC V ++ KV + +G A
Sbjct: 237 FCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTT 296
Query: 427 HRCKEMSEYCSTLCRHLYLFPGH 449
R TL R YLFPGH
Sbjct: 297 ERV--------TLTRCFYLFPGH 311
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 110 bits (275), Expect = 3e-24
Identities = 84/263 (31%), Positives = 120/263 (45%), Gaps = 27/263 (10%)
Query: 196 SRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKL 255
SR R LAL++ N F + R+G +VD + + L + LGY V V + TA +M +L
Sbjct: 160 SRTR-LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTEL 215
Query: 256 QNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQN 310
+ FA P H+ +DS + +SHG+ I G +LQL +F + + NCPSL++
Sbjct: 216 EAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKD 275
Query: 311 KPKMFFIQACRGDETDRGV----DQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMIC 366
KPK+ IQACRGD GV D + P EE + K + D I
Sbjct: 276 KPKVIIIQACRGDSP--GVVWFKDSVGVSGNLSLPTTEEFEDDAIK----KAHIEKDFIA 329
Query: 367 GYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEF 426
+ + R+ GS +I L + E AC V ++ KV + +G A
Sbjct: 330 FCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTT 389
Query: 427 HRCKEMSEYCSTLCRHLYLFPGH 449
R TL R YLFPGH
Sbjct: 390 ERV--------TLTRCFYLFPGH 404
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 110 bits (275), Expect = 3e-24
Identities = 84/263 (31%), Positives = 120/263 (45%), Gaps = 27/263 (10%)
Query: 196 SRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKL 255
SR R LAL++ N F + R+G +VD + + L + LGY V V + TA +M +L
Sbjct: 139 SRTR-LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTEL 194
Query: 256 QNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQN 310
+ FA P H+ +DS + +SHG+ I G +LQL +F + + NCPSL++
Sbjct: 195 EAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKD 254
Query: 311 KPKMFFIQACRGDETDRGV----DQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMIC 366
KPK+ IQACRGD GV D + P EE + K + D I
Sbjct: 255 KPKVIIIQACRGDSP--GVVWFKDSVGVSGNLSLPTTEEFEDDAIK----KAHIEKDFIA 308
Query: 367 GYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEF 426
+ + R+ GS +I L + E AC V ++ KV + +G A
Sbjct: 309 FCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTT 368
Query: 427 HRCKEMSEYCSTLCRHLYLFPGH 449
R TL R YLFPGH
Sbjct: 369 ERV--------TLTRCFYLFPGH 383
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 110 bits (274), Expect = 3e-24
Identities = 76/260 (29%), Positives = 118/260 (45%), Gaps = 10/260 (3%)
Query: 192 YRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEM 251
Y++ R RG+AL+ ++ F L R G D L F LG++V D A+E+
Sbjct: 37 YKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEEL 96
Query: 252 QEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNK 311
K+ + + +H D + LSHG IY D K+ ++Q + LF C SL K
Sbjct: 97 LLKIHEVSTV-SHADADCFVCVFLSHGEGNHIYAYDAKI-EIQTLTGLFKGDKCHSLVGK 154
Query: 312 PKMFFIQACRGDETDRGV---DQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGY 368
PK+F IQACRG++ D V D D + E DA LP +D + Y
Sbjct: 155 PKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAAS----VYTLPAGADFLMCY 210
Query: 369 ACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDRE-GYAPGTEFH 427
+ +G + R T GSWYI+ L ++ + + ++L VN + R +
Sbjct: 211 SVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAI 270
Query: 428 RCKEMSEYCSTLCRHLYLFP 447
K++ + S L + L+ FP
Sbjct: 271 GKKQVPCFASMLTKKLHFFP 290
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 107 bits (268), Expect = 2e-23
Identities = 73/234 (31%), Positives = 123/234 (52%), Gaps = 28/234 (11%)
Query: 219 RSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQ-LPAHRVTDSC-IVALLS 276
R G + D L +F+ L ++ + D TA++ QE+L+ F Q + + SC V L++
Sbjct: 29 REGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAIDSREDPVSCAFVVLMA 88
Query: 277 HGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKN 336
HG EG + G DG++++L+ +F+ +N NC +L+ KPK++ IQACRG++ D G
Sbjct: 89 HGREGFLKGEDGEMVKLENLFEALNNKNCQALRAKPKVYIIQACRGEQRDPG-------- 140
Query: 337 HAGSPGCEESDAGKE-----KLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALA 391
E+ G E K +PT +D + Y+ ++G A R+ ++GS +I+ L
Sbjct: 141 --------ETVGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAYRHDQKGSCFIQTLV 192
Query: 392 QVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYL 445
VF++R H+ ++L +V + + E G K E STL + LYL
Sbjct: 193 DVFTKR--KGHILELLTEVTRRMAEAELVQEG---KARKTNPEIQSTLRKRLYL 241
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 97.8 bits (242), Expect = 2e-20
Identities = 75/256 (29%), Positives = 118/256 (46%), Gaps = 18/256 (7%)
Query: 199 RGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNF 258
R LAL++ N F L R+G D + L + LGY V + TA++M+ L+ F
Sbjct: 205 RRLALIICNTKFD---HLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAF 261
Query: 259 AQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQNKPK 313
A P H+ +DS + L+SHG+ I G K +L +FQ+F+N NC SL++KPK
Sbjct: 262 AARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPK 321
Query: 314 MFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKG 373
+ +QACRG++ + + A +S E ++ D I +
Sbjct: 322 VIIVQACRGEKHGELWVRDSPASLALI--SSQSSENLEADSVCKIHEEKDFIAFCSSTPH 379
Query: 374 TAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMS 433
+ R+ RGS +I L F + +C H+ ++ KV + + A R
Sbjct: 380 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER----- 434
Query: 434 EYCSTLCRHLYLFPGH 449
+TL R YLFPG+
Sbjct: 435 ---ATLTRDFYLFPGN 447
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 97.8 bits (242), Expect = 2e-20
Identities = 75/256 (29%), Positives = 118/256 (46%), Gaps = 18/256 (7%)
Query: 199 RGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNF 258
R LAL++ N F L R+G D + L + LGY V + TA++M+ L+ F
Sbjct: 50 RRLALIICNTKFD---HLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAF 106
Query: 259 AQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQNKPK 313
A P H+ +DS + L+SHG+ I G K +L +FQ+F+N NC SL++KPK
Sbjct: 107 AARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPK 166
Query: 314 MFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKG 373
+ +QACRG++ + + A +S E ++ D I +
Sbjct: 167 VIIVQACRGEKHGELWVRDSPASLALI--SSQSSENLEADSVCKIHEEKDFIAFCSSTPH 224
Query: 374 TAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMS 433
+ R+ RGS +I L F + +C H+ ++ KV + + A R
Sbjct: 225 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER----- 279
Query: 434 EYCSTLCRHLYLFPGH 449
+TL R YLFPG+
Sbjct: 280 ---ATLTRDFYLFPGN 292
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 97.8 bits (242), Expect = 2e-20
Identities = 75/256 (29%), Positives = 118/256 (46%), Gaps = 18/256 (7%)
Query: 199 RGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNF 258
R LAL++ N F L R+G D + L + LGY V + TA++M+ L+ F
Sbjct: 134 RRLALIICNTKFD---HLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAF 190
Query: 259 AQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQNKPK 313
A P H+ +DS + L+SHG+ I G K +L +FQ+F+N NC SL++KPK
Sbjct: 191 AARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPK 250
Query: 314 MFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKG 373
+ +QACRG++ + + A +S E ++ D I +
Sbjct: 251 VIIVQACRGEKHGELWVRDSPASLALI--SSQSSENLEADSVCKIHEEKDFIAFCSSTPH 308
Query: 374 TAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMS 433
+ R+ RGS +I L F + +C H+ ++ KV + + A R
Sbjct: 309 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER----- 363
Query: 434 EYCSTLCRHLYLFPGH 449
+TL R YLFPG+
Sbjct: 364 ---ATLTRDFYLFPGN 376
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 97.8 bits (242), Expect = 2e-20
Identities = 75/256 (29%), Positives = 118/256 (46%), Gaps = 18/256 (7%)
Query: 199 RGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNF 258
R LAL++ N F L R+G D + L + LGY V + TA++M+ L+ F
Sbjct: 192 RRLALIICNTKFD---HLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAF 248
Query: 259 AQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQNKPK 313
A P H+ +DS + L+SHG+ I G K +L +FQ+F+N NC SL++KPK
Sbjct: 249 AARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPK 308
Query: 314 MFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKG 373
+ +QACRG++ + + A +S E ++ D I +
Sbjct: 309 VIIVQACRGEKHGELWVRDSPASLALI--SSQSSENLEADSVCKIHEEKDFIAFCSSTPH 366
Query: 374 TAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMS 433
+ R+ RGS +I L F + +C H+ ++ KV + + A R
Sbjct: 367 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER----- 421
Query: 434 EYCSTLCRHLYLFPGH 449
+TL R YLFPG+
Sbjct: 422 ---ATLTRDFYLFPGN 434
>gi|15431332 caspase 1 isoform delta [Homo sapiens]
Length = 263
Score = 96.3 bits (238), Expect = 5e-20
Identities = 75/259 (28%), Positives = 107/259 (41%), Gaps = 67/259 (25%)
Query: 196 SRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKL 255
SR R LAL++ N F + R+G +VD + + L + LGY V V + TA +M +L
Sbjct: 67 SRTR-LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTEL 122
Query: 256 QNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQN 310
+ FA P H+ +DS + +SHG+ I G +LQL +F + + NCPSL++
Sbjct: 123 EAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKD 182
Query: 311 KPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYAC 370
KPK+ IQACRGD
Sbjct: 183 KPKVIIIQACRGD----------------------------------------------- 195
Query: 371 LKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCK 430
+ R+ GS +I L + E AC V ++ KV + +G A R
Sbjct: 196 ---NVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERV- 251
Query: 431 EMSEYCSTLCRHLYLFPGH 449
TL R YLFPGH
Sbjct: 252 -------TLTRCFYLFPGH 263
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 94.7 bits (234), Expect = 1e-19
Identities = 73/254 (28%), Positives = 117/254 (46%), Gaps = 18/254 (7%)
Query: 201 LALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQ 260
LAL++ N F L R+G D D + + L + L Y V V + TA++M+ L+ FA
Sbjct: 81 LALIICNTEFD---HLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 137
Query: 261 LPAHRVTDSCIVALLSHGVEGAIYGV--DGK---LLQLQEVFQLFDNANCPSLQNKPKMF 315
P H+ +DS + L+SHG+ I G D K +L +FQ+F+N NC SL++KPK+
Sbjct: 138 RPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 197
Query: 316 FIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTA 375
+QACRG +RG + +S E+ + D I +
Sbjct: 198 IVQACRG--ANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNV 255
Query: 376 AMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEY 435
+ R++ GS +I L F + + H+ ++ KV + A R
Sbjct: 256 SWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERL------ 309
Query: 436 CSTLCRHLYLFPGH 449
++ R+ YLFPG+
Sbjct: 310 --SMTRYFYLFPGN 321
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 94.7 bits (234), Expect = 1e-19
Identities = 73/254 (28%), Positives = 117/254 (46%), Gaps = 18/254 (7%)
Query: 201 LALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQ 260
LAL++ N F L R+G D D + + L + L Y V V + TA++M+ L+ FA
Sbjct: 137 LALIICNTEFD---HLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFAT 193
Query: 261 LPAHRVTDSCIVALLSHGVEGAIYGV--DGK---LLQLQEVFQLFDNANCPSLQNKPKMF 315
P H+ +DS + L+SHG+ I G D K +L +FQ+F+N NC SL++KPK+
Sbjct: 194 RPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 253
Query: 316 FIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTA 375
+QACRG +RG + +S E+ + D I +
Sbjct: 254 IVQACRG--ANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNV 311
Query: 376 AMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEY 435
+ R++ GS +I L F + + H+ ++ KV + A R
Sbjct: 312 SWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERL------ 365
Query: 436 CSTLCRHLYLFPGH 449
++ R+ YLFPG+
Sbjct: 366 --SMTRYFYLFPGN 377
>gi|209870075 caspase 5 isoform d [Homo sapiens]
Length = 216
Score = 88.6 bits (218), Expect = 1e-17
Identities = 65/223 (29%), Positives = 104/223 (46%), Gaps = 15/223 (6%)
Query: 232 LFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-- 289
L + LGY V + TA++M+ L+ FA P H+ +DS + L+SHG+ I G K
Sbjct: 4 LLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKK 63
Query: 290 ---LLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEES 346
+L +FQ+F+N NC SL++KPK+ +QACRG++ + + A +S
Sbjct: 64 KPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALI--SSQS 121
Query: 347 DAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADM 406
E ++ D I + + R+ RGS +I L F + +C H+ ++
Sbjct: 122 SENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEI 181
Query: 407 LVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGH 449
KV + + A R +TL R YLFPG+
Sbjct: 182 FRKVQKSFEVPQAKAQMPTIER--------ATLTRDFYLFPGN 216
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 83.2 bits (204), Expect = 4e-16
Identities = 56/189 (29%), Positives = 85/189 (44%), Gaps = 9/189 (4%)
Query: 263 AHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG 322
+H D + LSHG IY D K+ ++Q + LF C SL KPK+F IQACRG
Sbjct: 18 SHADADCFVCVFLSHGEGNHIYAYDAKI-EIQTLTGLFKGDKCHSLVGKPKIFIIQACRG 76
Query: 323 DETDRGV---DQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRN 379
++ D V D D + E DA LP +D + Y+ +G + R
Sbjct: 77 NQHDVPVIPLDVVDNQTEKLDTNITEVDAAS----VYTLPAGADFLMCYSVAEGYYSHRE 132
Query: 380 TKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDRE-GYAPGTEFHRCKEMSEYCST 438
T GSWYI+ L ++ + + ++L VN + R + K++ + S
Sbjct: 133 TVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASM 192
Query: 439 LCRHLYLFP 447
L + L+ FP
Sbjct: 193 LTKKLHFFP 201
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,422,666
Number of Sequences: 37866
Number of extensions: 817463
Number of successful extensions: 2063
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1954
Number of HSP's gapped (non-prelim): 56
length of query: 452
length of database: 18,247,518
effective HSP length: 106
effective length of query: 346
effective length of database: 14,233,722
effective search space: 4924867812
effective search space used: 4924867812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.