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Search of human proteins with 39930479
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39930479 DIX domain containing 1 isoform b [Homo sapiens]
(472 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39930479 DIX domain containing 1 isoform b [Homo sapiens] 945 0.0
gi|83816971 DIX domain containing 1 isoform a [Homo sapiens] 927 0.0
gi|4758216 dishevelled 2 [Homo sapiens] 77 3e-14
gi|32479521 dishevelled 1 [Homo sapiens] 72 8e-13
gi|41406097 dishevelled 3 [Homo sapiens] 72 8e-13
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 55 1e-07
gi|71061468 centromere protein E [Homo sapiens] 54 4e-07
gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sa... 54 4e-07
gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sap... 54 4e-07
gi|110347443 TATA element modulatory factor 1 [Homo sapiens] 52 9e-07
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 52 9e-07
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 52 9e-07
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 52 9e-07
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 52 9e-07
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 52 1e-06
gi|34577114 cytomatrix protein p110 [Homo sapiens] 52 1e-06
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 52 2e-06
gi|203096856 kinesin family member 7 [Homo sapiens] 51 2e-06
gi|148746195 trichohyalin [Homo sapiens] 51 3e-06
gi|195927059 axin 2 [Homo sapiens] 50 3e-06
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 50 3e-06
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 50 3e-06
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 50 3e-06
gi|21735548 centrosomal protein 2 [Homo sapiens] 49 8e-06
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 49 8e-06
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 49 8e-06
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 49 8e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 49 8e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 49 8e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 49 8e-06
>gi|39930479 DIX domain containing 1 isoform b [Homo sapiens]
Length = 472
Score = 945 bits (2442), Expect = 0.0
Identities = 472/472 (100%), Positives = 472/472 (100%)
Query: 1 MGGTQVKCLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGS 60
MGGTQVKCLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGS
Sbjct: 1 MGGTQVKCLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGS 60
Query: 61 PGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVN 120
PGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVN
Sbjct: 61 PGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVN 120
Query: 121 PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE
Sbjct: 121 PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
Query: 181 LLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDV 240
LLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDV
Sbjct: 181 LLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDV 240
Query: 241 SYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTS 300
SYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTS
Sbjct: 241 SYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTS 300
Query: 301 DLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRT 360
DLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRT
Sbjct: 301 DLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRT 360
Query: 361 QVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFK 420
QVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFK
Sbjct: 361 QVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFK 420
Query: 421 AAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN 472
AAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN
Sbjct: 421 AAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN 472
>gi|83816971 DIX domain containing 1 isoform a [Homo sapiens]
Length = 683
Score = 927 bits (2397), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 9 LTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETS 68
LTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETS
Sbjct: 220 LTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETS 279
Query: 69 WEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIII 128
WEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIII
Sbjct: 280 WEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIII 339
Query: 129 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK 188
QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK
Sbjct: 340 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK 399
Query: 189 DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLE 248
DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLE
Sbjct: 400 DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLE 459
Query: 249 RELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDA 308
RELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDA
Sbjct: 460 RELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDA 519
Query: 309 LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRE 368
LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRE
Sbjct: 520 LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRE 579
Query: 369 SWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGN 428
SWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGN
Sbjct: 580 SWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGN 639
Query: 429 HRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN 472
HRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN
Sbjct: 640 HRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN 683
>gi|4758216 dishevelled 2 [Homo sapiens]
Length = 736
Score = 77.0 bits (188), Expect = 3e-14
Identities = 33/76 (43%), Positives = 50/76 (65%)
Query: 390 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFH 449
TKV+Y D TP++V IP E +TL DFK+ + R +Y FK++D +FG VKEEI
Sbjct: 14 TKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISD 73
Query: 450 DDDAIPGWEGKIVAWV 465
D+ +P + G++V+W+
Sbjct: 74 DNARLPCFNGRVVSWL 89
>gi|32479521 dishevelled 1 [Homo sapiens]
Length = 670
Score = 72.4 bits (176), Expect = 8e-13
Identities = 33/78 (42%), Positives = 49/78 (62%), Gaps = 2/78 (2%)
Query: 390 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHF--KALDPEFGTVKEEI 447
TK++Y D TP++V +P E VTL DFK + H Y F K++D +FG VKEEI
Sbjct: 4 TKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEI 63
Query: 448 FHDDDAIPGWEGKIVAWV 465
F D+ +P + G++V+W+
Sbjct: 64 FDDNAKLPCFNGRVVSWL 81
>gi|41406097 dishevelled 3 [Homo sapiens]
Length = 716
Score = 72.4 bits (176), Expect = 8e-13
Identities = 32/83 (38%), Positives = 53/83 (63%), Gaps = 1/83 (1%)
Query: 390 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFH 449
TK++Y D TP++V +P E VTL DFK + R ++++ FK++D +FG VKEEI
Sbjct: 4 TKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRP-SYKFFFKSMDDDFGVVKEEISD 62
Query: 450 DDDAIPGWEGKIVAWVEEDHGEN 472
D+ +P + G++V+W+ G +
Sbjct: 63 DNAKLPCFNGRVVSWLVSAEGSH 85
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 55.5 bits (132), Expect = 1e-07
Identities = 63/304 (20%), Positives = 132/304 (43%), Gaps = 34/304 (11%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLA-----LCEPGVNPEEQL 125
E+L Q E +++ +E +K +S LQ ++ + +R L + + + +E L
Sbjct: 771 ERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 830
Query: 126 IIIQSRLDQSMEENQDLKKELLKCKQEA----RNLQGIKDALQQRLTQQDTSVLQLKQEL 181
+Q+++ + + + L L CK+E L+G K+ +++L ++ V L++EL
Sbjct: 831 KALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKEL 890
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGE--------------YKKELGQKDRLLQQHQ 227
N E QNV LQ L ++ ++L + +K++ + ++ LQ+ +
Sbjct: 891 KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQR 950
Query: 228 AKLEEALRKLS---DVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLL 284
E LRK+ + + H+ DL+R+ K + L ++ E Y S+ ++
Sbjct: 951 ESSAEKLRKMEEKCESAAHEADLKRQ---KVIELTGTARQVKIEMDQYKEELSKMEKEIM 1007
Query: 285 PTAGKGATSVSNRGTSDLQL--VRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHV 342
G + D+ L + L N+ + H S E ++ +++ V
Sbjct: 1008 HLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQH---STETELTEALQKREV 1064
Query: 343 METQ 346
+ET+
Sbjct: 1065 LETE 1068
Score = 47.4 bits (111), Expect = 3e-05
Identities = 44/202 (21%), Positives = 92/202 (45%), Gaps = 18/202 (8%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLI-IIQ 129
+Q E+ +EKE+ K+ L + D+ + L V E+L +
Sbjct: 993 DQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTE 1052
Query: 130 SRLDQSMEENQDLKKELLKC----KQEARNLQGIKDALQQR---LTQQDTSVLQLKQELL 182
+ L +++++ + L+ EL K R LQ ++D LQ+ L ++ T++ L EL
Sbjct: 1053 TELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELR 1112
Query: 183 RANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSY 242
M+ ++ + +++ + L ERN L + ++ D +++H+ ++E+ +
Sbjct: 1113 ECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKI-------- 1164
Query: 243 HQVDLERELEHKDVLLAHCMKR 264
+ LE LE ++ L C K+
Sbjct: 1165 --IKLEGTLEKSELELKECNKQ 1184
Score = 41.6 bits (96), Expect = 0.002
Identities = 46/212 (21%), Positives = 96/212 (45%), Gaps = 48/212 (22%)
Query: 70 EEQLLEQQEYLEK---EMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLI 126
E+++++ + LEK E++E K I L L N EQ R E++ I
Sbjct: 1161 EQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAK----EQLR-----------EKEFI 1205
Query: 127 IIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL----- 181
++Q+ +E LKKE+ + +Q + ++ + +Q + Q + L QEL
Sbjct: 1206 MLQNE-----QEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTRE 1260
Query: 182 --LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKD-------------RLLQQH 226
++ + E +Q V QR+++ + L + K+ +KD ++ + H
Sbjct: 1261 QVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAH 1320
Query: 227 -QAKLEEALRKLSDVSYHQVDLERELEHKDVL 257
+A+++ ++KLS +V+ +E H +++
Sbjct: 1321 LEARMQAEIKKLS----AEVESLKEAYHMEMI 1348
Score = 40.0 bits (92), Expect = 0.005
Identities = 43/198 (21%), Positives = 88/198 (44%), Gaps = 20/198 (10%)
Query: 80 LEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSR-LDQSMEE 138
LE ++A + L+ ++N Q++ L E + ++++I + + L +S EE
Sbjct: 276 LESAQQQAAS-VPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEE 334
Query: 139 NQDLKKELLKCKQEAR-----------NLQGIKDALQQ--RLTQQDTSVLQLKQELLRAN 185
LK +LL+ ++ + N + + A QQ + + +Q ++E+L N
Sbjct: 335 CIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERN 394
Query: 186 MDKDELHNQNVD-----LQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDV 240
+ E N+ + + +L+ L + K+E L+ K E + +L++
Sbjct: 395 LTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTES 454
Query: 241 SYHQVDLERELEHKDVLL 258
+ LE ELE+KD +L
Sbjct: 455 RQSILKLESELENKDEIL 472
Score = 35.4 bits (80), Expect = 0.11
Identities = 54/300 (18%), Positives = 121/300 (40%), Gaps = 55/300 (18%)
Query: 83 EMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDL 142
EM++ K+ +S ++ +++ L D + + + L QL +I + +E+ +
Sbjct: 991 EMDQYKEELSKMEKEIMH--LKRDGENKAMHL--------SQLDMILDQTKTELEKKTNA 1040
Query: 143 KKELLKCKQEARNLQGIKDALQQR-------------LTQQDTSVLQLKQELLRANMDKD 189
KEL K + + +ALQ+R L + +L+ L +A + +
Sbjct: 1041 VKELEKLQHSTET--ELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 190 ELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLER 249
E + DL +L E + + K+EL + D+ L++ +L++ +++ + +
Sbjct: 1099 EKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRG 1158
Query: 250 ELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDAL 309
E+E K + L +++ E N N LQ ++ L
Sbjct: 1159 EMEQKIIKLEGTLEKSELELKECNKQIESLN-------------------DKLQNAKEQL 1199
Query: 310 RSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRES 369
R ++ + I L++ I +R+ ME+ K++ + + ++Y+E+
Sbjct: 1200 REKEFIMLQNEQE---ISQLKKEIERTQQRMKEMESVMKEQEQ--------YIATQYKEA 1248
Score = 35.4 bits (80), Expect = 0.11
Identities = 40/200 (20%), Positives = 90/200 (45%), Gaps = 10/200 (5%)
Query: 66 ETSWE-EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQ 124
E +WE +Q Q +L+ + E + + + + L G+L + E E L C +Q
Sbjct: 1134 ERNWELKQRAAQVTHLDMTIREHRGEMEQ-KIIKLEGTLEKSELE--LKECN------KQ 1184
Query: 125 LIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRA 184
+ + +L + E+ ++ + +L+ +QE L+ + QQR+ + ++ + + +Q +
Sbjct: 1185 IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQ 1244
Query: 185 NMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQ 244
+ +L + + ++ + L E + + Q R +++ ++LE+ + + H
Sbjct: 1245 YKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHG 1304
Query: 245 VDLERELEHKDVLLAHCMKR 264
L EL V AH R
Sbjct: 1305 NHLAEELGASKVREAHLEAR 1324
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 53.5 bits (127), Expect = 4e-07
Identities = 62/288 (21%), Positives = 138/288 (47%), Gaps = 32/288 (11%)
Query: 80 LEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEEN 139
L+K++ E +K +S ++ L + +++ L L + + E L + Q +L +++EE
Sbjct: 1835 LKKDVNETQKKVSEME------QLKKQIKDQSLTLSKLEI---ENLNLAQ-KLHENLEEM 1884
Query: 140 QDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVD-L 198
+ + KE ++ L+ +D L++ L + L+++QEL A M E H + VD L
Sbjct: 1885 KSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKE-HKETVDKL 1943
Query: 199 QRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLL 258
+ K+ E+ + + +K+L D+ + Q K++E +K ++ +V + + HK +
Sbjct: 1944 REKISEKTIQISDIQKDL---DKSKDELQKKIQELQKK--ELQLLRVKEDVNMSHKKINE 1998
Query: 259 AHCMKREADEATNYNSHNSQSNGFLLPT---AGKGATSVSNRGTSDLQLVRDALRSLRNS 315
+K++ EA N + + + + F L + + +L+ ++++L+ R+
Sbjct: 1999 MEQLKKQF-EAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQ 2057
Query: 316 F-------SGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVK 356
F D Q+H + ++ +S + L T+ +E+ R+K
Sbjct: 2058 FIATLREMIARDRQNHQVKPEKRLLSDGQQHL----TESLREKCSRIK 2101
Score = 48.5 bits (114), Expect = 1e-05
Identities = 68/298 (22%), Positives = 124/298 (41%), Gaps = 40/298 (13%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
E ++ + Q+ L KE+EE + + + L SLP + + L + + E+L II
Sbjct: 719 EGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVER----LRKEIQDKSEELHIIT 774
Query: 130 SRLDQSMEEN-------QDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELL 182
S D+ E Q L +E+ K K + Q + Q T + +Q+
Sbjct: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYK 834
Query: 183 RANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSY 242
+ + ++ + V+L ++ + + LG K EL K + LQ+ +++E L ++
Sbjct: 835 MVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQ--- 891
Query: 243 HQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDL 302
L+ +LE++D L ++RE T + + T + + S L
Sbjct: 892 ----LKEQLENRDSTL-QTVEREKTLITEKLQQTLEE----VKTLTQEKDDLKQLQES-L 941
Query: 303 QLVRDALRS---------------LRNSFSGHDPQHHTIDSLEQGISSLMER-LHVME 344
Q+ RD L+S LRN+ TI++L+ IS + R LH+ E
Sbjct: 942 QIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEE 999
Score = 43.5 bits (101), Expect = 4e-04
Identities = 73/326 (22%), Positives = 137/326 (42%), Gaps = 62/326 (19%)
Query: 73 LLEQQEYLE--KEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
L E+QE L KE+ E ++ ++ L+ LL S +D LA E E+L
Sbjct: 1285 LHEEQELLPNVKEVSETQETMNELE-LLTEQSTTKDSTT--LARIEM-----ERL----- 1331
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDE 190
RL++ +E+Q+ K L K E NL+ IK+AL+ + Q + +E L +
Sbjct: 1332 RLNEKFQESQEEIKSLTK---ERDNLKTIKEALEVKHDQLKEHI----RETLAKIQESQS 1384
Query: 191 LHNQNVDLQRKLDERNRLLGEYK--------------KELGQKDRLLQQHQ-----AKLE 231
Q+++++ K +E +++ E + + LG RL + H AK +
Sbjct: 1385 KQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1444
Query: 232 EALRKLSDVSYHQVD---------LERELEHKDVL-LAHCMKREADEATNYNSHNSQSNG 281
+ L++L +V + D + + LE ++ L +AHC +E +E N N
Sbjct: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE 1504
Query: 282 FLLPTAGKGATSVSNRGTSDLQLVRD-----------ALRSLRNSFSGHDPQHHTIDSLE 330
+ T K +++++ + +Q + + ++ N DS
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSAL 1564
Query: 331 QGISSLMERLHVMETQKKQERKVRVK 356
Q I S M L + ++E ++ +K
Sbjct: 1565 QSIESKMLELTNRLQESQEEIQIMIK 1590
Score = 40.4 bits (93), Expect = 0.004
Identities = 68/357 (19%), Positives = 152/357 (42%), Gaps = 51/357 (14%)
Query: 71 EQLLEQQEYLEKEMEEAKKM-ISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
E ++ ++E L+ +++E +M I + L L G + +QE + E +L
Sbjct: 1060 ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTC 1119
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLK-QELLRANMDK 188
RL + E+ ++ ++L + +Q+ N+Q +Q+++ + + +LK +EL +M+
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179
Query: 189 DELH-----NQNVDLQRKLDERNRLLGEYKKEL-GQKDRL-------------------- 222
+ L N+N + + + + ++L E +K ++D L
Sbjct: 1180 ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKI 1239
Query: 223 ----LQQHQAKLEEALRKLSDVSYHQV---DLERELE--HKDVLLAHCMKREADEATNYN 273
L++HQ ++E R +S+ + + DLE+ +++ + H + +
Sbjct: 1240 AHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVS 1299
Query: 274 SHNSQSNGFLLPT---AGKGATSVSNRGTSDLQL---VRDALRSLRNSFSGHDPQHHTID 327
N L T K +T+++ L+L +++ +++ D +
Sbjct: 1300 ETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKE 1359
Query: 328 SLEQGISSLMERLH-----VMETQKKQERKVRVK---SPRTQVGSEYRESWPPNSKL 376
+LE L E + + E+Q KQE+ + +K + T++ SE + P +S L
Sbjct: 1360 ALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSAL 1416
Score = 39.7 bits (91), Expect = 0.006
Identities = 37/165 (22%), Positives = 76/165 (46%), Gaps = 9/165 (5%)
Query: 120 NPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQ 179
N E + I + L +++EE + + KE + L+ +D L++ L + T L+ ++
Sbjct: 1662 NIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQE 1721
Query: 180 ELLRANMDKDELHNQNVD-LQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLS 238
EL +M E H + +D L+ + E+ + +K+L + L+ K++E LR
Sbjct: 1722 ELKIVHMHLKE-HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELR--- 1777
Query: 239 DVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFL 283
+++ + ++E K L + + D+ +N SN L
Sbjct: 1778 -IAHMHLKEQQETIDK---LRGIVSEKTDKLSNMQKDLENSNAKL 1818
Score = 37.0 bits (84), Expect = 0.039
Identities = 52/225 (23%), Positives = 100/225 (44%), Gaps = 20/225 (8%)
Query: 65 LETSWEEQLLEQQEYLEKEMEEAKKMISGLQ---ALLLNGSLPEDEQERPLALCEPGVNP 121
++ S+ + +E + +++ + +A+ + + A L + +L E+ + LA +
Sbjct: 608 MDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMEN 667
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
+ QL QS+L+ + DL+KEL E L + D ++ + L+L+ ++
Sbjct: 668 DIQLY--QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDG---KVPKDLLCNLELEGKI 722
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVS 241
D + N+ V+ L E LL E K + +RL ++ Q K EE L ++
Sbjct: 723 ----TDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEE----LHIIT 774
Query: 242 YHQVDLERELEHKDV----LLAHCMKREADEATNYNSHNSQSNGF 282
+ L E+ HK+ LL K + D AT +++ S F
Sbjct: 775 SEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEF 819
Score = 37.0 bits (84), Expect = 0.039
Identities = 60/291 (20%), Positives = 135/291 (46%), Gaps = 25/291 (8%)
Query: 72 QLLEQQEYLE---KEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIII 128
+L E QE ++ KE EE K++ LQ + L E+ +E + E +E +
Sbjct: 1577 RLQESQEEIQIMIKEKEEMKRVQEALQ--IERDQLKENTKEIVAKMKES--QEKEYQFLK 1632
Query: 129 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRA-NMD 187
+ ++++ E+ +++ + + + NL+ I+ RLTQ +L E +R+ +
Sbjct: 1633 MTAVNETQEKMCEIEHLKEQFETQKLNLENIETE-NIRLTQ----ILHENLEEMRSVTKE 1687
Query: 188 KDELHNQNVDLQRKLDERNRLLGE-YKKELGQKDRL------LQQHQAKLEEALRKLSDV 240
+D+L + L+ + D+ L E ++L +++ L L++HQ +++ +S+
Sbjct: 1688 RDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEK 1747
Query: 241 SYHQVDLERELEH-KDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGT 299
+ +++++LEH D L A +K + +E + H + + +G S
Sbjct: 1748 TNEISNMQKDLEHSNDALKAQDLKIQ-EELRIAHMHLKEQQETI--DKLRGIVSEKTDKL 1804
Query: 300 SDLQL-VRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQ 349
S++Q + ++ L+ H + +L++ ++ +++ ME KKQ
Sbjct: 1805 SNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Score = 35.0 bits (79), Expect = 0.15
Identities = 54/280 (19%), Positives = 118/280 (42%), Gaps = 42/280 (15%)
Query: 39 EGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALL 98
E ++ + E DS L R + L T +Q LE+ + L +E ++ K++ LQ
Sbjct: 890 EQLKEQLENRDSTLQTVEREKT----LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIER 945
Query: 99 --LNGSLPE------DEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCK 150
L + + D QE+ E +E + ++S++ + + N +++ + K
Sbjct: 946 DQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK 1005
Query: 151 QE-ARNLQGI--KDALQQRLTQ------QDTSVLQLKQELLRANMDKDELHN-------- 193
E + + GI K L+ + TQ +D +++ ++++ +K+EL
Sbjct: 1006 DEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAE 1065
Query: 194 ---------QNVDLQRKLDERNRLLG-EYKKE---LGQKDRLLQQHQAKLEEALRKLSDV 240
+N+++ + E RLLG E KK+ + Q+ + + +L +L++V
Sbjct: 1066 KEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEV 1125
Query: 241 SYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSN 280
+ ++L+ K L + + ++ N + N
Sbjct: 1126 EEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165
Score = 32.0 bits (71), Expect = 1.2
Identities = 53/206 (25%), Positives = 88/206 (42%), Gaps = 54/206 (26%)
Query: 71 EQLLEQQEYLEKEM----EEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLI 126
+ +LE+ E + +E+ +EA+K S L AL S E + E+
Sbjct: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ-------------EKTR 880
Query: 127 IIQSRLDQSMEENQDLKKEL------LKCKQEARNLQGIKDALQQ------RLTQQDTSV 174
+Q RL+ E + LK++L L+ + + L I + LQQ LTQ+ +
Sbjct: 881 EVQERLN----EMEQLKEQLENRDSTLQTVEREKTL--ITEKLQQTLEEVKTLTQEKDDL 934
Query: 175 LQLKQEL-LRANMDKDELH---NQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKL 230
QL++ L + + K ++H N N+D Q +L RN L L+QHQ +
Sbjct: 935 KQLQESLQIERDQLKSDIHDTVNMNIDTQEQL--RNAL------------ESLKQHQETI 980
Query: 231 EEALRKLSDVSYHQVDLEREL-EHKD 255
K+S+ + +E E KD
Sbjct: 981 NTLKSKISEEVSRNLHMEENTGETKD 1006
Score = 29.3 bits (64), Expect = 8.1
Identities = 30/145 (20%), Positives = 72/145 (49%), Gaps = 16/145 (11%)
Query: 123 EQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELL 182
++L +Q L+ S + Q+ +EL + + L+ + Q+++++ + Q+K + L
Sbjct: 1802 DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSL 1861
Query: 183 RANMDKDELHNQNV--DLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDV 240
+ K E+ N N+ L L+E ++ E + L + + L+ + +L+E+L+ +
Sbjct: 1862 --TLSKLEIENLNLAQKLHENLEEMKSVMKE-RDNLRRVEETLKLERDQLKESLQ---ET 1915
Query: 241 SYHQVDLEREL--------EHKDVL 257
+++++EL EHK+ +
Sbjct: 1916 KARDLEIQQELKTARMLSKEHKETV 1940
>gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo
sapiens]
Length = 1185
Score = 53.5 bits (127), Expect = 4e-07
Identities = 71/316 (22%), Positives = 121/316 (38%), Gaps = 37/316 (11%)
Query: 41 IENRTEGTDSPLSRDWRPGSPGTYLETSWEEQL---LEQQEYLEKEMEEAKKMISGLQAL 97
I + E T S + GS S EE L +E QE + K+ E +M
Sbjct: 223 INHEQENTPSTSGKRSSDGS------LSHEEDLAKVIELQEIISKQSREQSQM------- 269
Query: 98 LLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQ 157
+ER +L EE L + L +S E N L++++ + + +++
Sbjct: 270 ----------KERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
Query: 158 GIKDALQQRLT---QQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKK 214
L++R ++ TSV L +L +KD +H Q D R+L ER L + +
Sbjct: 320 ERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQ 379
Query: 215 ELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNS 274
+ +K L + +A+L + + LS ++E L + L +E A
Sbjct: 380 QTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEE-KNQELQRARQREK 438
Query: 275 HNSQSNGFLLPTAGKGATSVSNR-------GTSDLQLVRDALRSLRNSFSGHDPQHHTID 327
N + N L T K + + R + L+ LR + ++ + H D
Sbjct: 439 MNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKD 498
Query: 328 SLEQGISSLMERLHVM 343
L I +L L M
Sbjct: 499 QLVLNIEALRAELDHM 514
>gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo
sapiens]
Length = 1202
Score = 53.5 bits (127), Expect = 4e-07
Identities = 71/316 (22%), Positives = 121/316 (38%), Gaps = 37/316 (11%)
Query: 41 IENRTEGTDSPLSRDWRPGSPGTYLETSWEEQL---LEQQEYLEKEMEEAKKMISGLQAL 97
I + E T S + GS S EE L +E QE + K+ E +M
Sbjct: 223 INHEQENTPSTSGKRSSDGS------LSHEEDLAKVIELQEIISKQSREQSQM------- 269
Query: 98 LLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQ 157
+ER +L EE L + L +S E N L++++ + + +++
Sbjct: 270 ----------KERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
Query: 158 GIKDALQQRLT---QQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKK 214
L++R ++ TSV L +L +KD +H Q D R+L ER L + +
Sbjct: 320 ERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQ 379
Query: 215 ELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNS 274
+ +K L + +A+L + + LS ++E L + L +E A
Sbjct: 380 QTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEE-KNQELQRARQREK 438
Query: 275 HNSQSNGFLLPTAGKGATSVSNR-------GTSDLQLVRDALRSLRNSFSGHDPQHHTID 327
N + N L T K + + R + L+ LR + ++ + H D
Sbjct: 439 MNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKD 498
Query: 328 SLEQGISSLMERLHVM 343
L I +L L M
Sbjct: 499 QLVLNIEALRAELDHM 514
>gi|110347443 TATA element modulatory factor 1 [Homo sapiens]
Length = 1093
Score = 52.4 bits (124), Expect = 9e-07
Identities = 69/290 (23%), Positives = 127/290 (43%), Gaps = 25/290 (8%)
Query: 2 GGTQVKCLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDS-PLSRDWRPGS 60
G V + + S S ES +SEE + ++IP E E G + P++ +
Sbjct: 352 GYALVPIIVNSSTPKSKTVESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNCE----Q 407
Query: 61 PGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVN 120
P + ++ + E Q L+K E+ + S +AL S ED + L E
Sbjct: 408 PDILVSST---PINEGQTVLDKVAEQCEPAESQPEAL----SEKEDVCKTVEFLNEKLEK 460
Query: 121 PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
E QL+ + E +LK E+ + K+E+ ++ +KD QR+ + + V +E
Sbjct: 461 REAQLLSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKE 520
Query: 181 LLRANMD----KDEL-----HNQNVDLQRKLDERNRLLGEYKKELGQK----DRLLQQHQ 227
A + K+EL ++ DL ++ DE+ R L E ++L ++ ++++ +
Sbjct: 521 RDAAKKEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLR 580
Query: 228 AKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNS 277
AK +E ++ ++ +LE EL+H +L + E N NS
Sbjct: 581 AKDKENENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNS 630
Score = 39.3 bits (90), Expect = 0.008
Identities = 50/232 (21%), Positives = 104/232 (44%), Gaps = 31/232 (13%)
Query: 65 LETSWEEQLLEQQ-EYLEKEMEEAKKMISGLQALL--LNGSLPEDEQERPLALCEPGVNP 121
L S E+ LLE+ + L+ EM K+ S + +L + E E++ LA E
Sbjct: 466 LSLSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAK 525
Query: 122 EEQLII---IQSRLDQS----------------MEENQDLKKELLKCKQEARNLQGIKDA 162
+E I + +RL+ S MEE + L K+ L + L+
Sbjct: 526 KEIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKE 585
Query: 163 LQQRLTQQDTSVLQLKQEL------LRANMDKDELHNQNV-DLQRKLDERNRLLGEYKKE 215
+ + + + V +L++EL L + ++ H +N+ L ++ + + LG + +
Sbjct: 586 NENMVAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVD 645
Query: 216 LGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREAD 267
+ + + + QA L+ A ++L+D+ H+ + ++ E ++ L+ MK + +
Sbjct: 646 MDELEEKNRSIQAALDSAYKELTDL--HKANAAKDSEAQEAALSREMKAKEE 695
Score = 35.8 bits (81), Expect = 0.087
Identities = 40/174 (22%), Positives = 80/174 (45%), Gaps = 20/174 (11%)
Query: 71 EQLLEQQEYLEKEMEEAK--------KMISGLQALLLNGSLPEDEQERPLALCEPGVNPE 122
+Q L++ E +E+ ++ + I LQA L + + ++ E+ L+
Sbjct: 747 QQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLS--------- 797
Query: 123 EQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELL 182
++L Q+ L ++E + +ELL K + +++ L+Q ++ QL+ E
Sbjct: 798 DRLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQA---QLESEKN 854
Query: 183 RANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRK 236
R +DE + V+L+ DE R L E +KE + L+ + K+E+ +K
Sbjct: 855 RLCKLEDENNRYQVELENLKDEYVRTLEETRKEKTLLNSQLEMERMKVEQERKK 908
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 52.4 bits (124), Expect = 9e-07
Identities = 50/218 (22%), Positives = 100/218 (45%), Gaps = 22/218 (10%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP------EE 123
E +L E+++ ++ E KKM Q L L L E+E R E E+
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQ--QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 985
Query: 124 QLIIIQSRLDQSMEENQ-------DLKKELLKCKQEARNLQGIKDA-------LQQRLTQ 169
+++++ + ++ +E + DL L + +++A+NL +K+ L+ RL +
Sbjct: 986 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 170 QDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAK 229
++ S +L++ + D + H Q DLQ ++ E L + ++EL L A+
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105
Query: 230 LEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREAD 267
AL+K+ ++ H DL+ +L+ + K++ D
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Score = 43.9 bits (102), Expect = 3e-04
Identities = 78/356 (21%), Positives = 142/356 (39%), Gaps = 78/356 (21%)
Query: 40 GIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLL 99
G+ N EG L++D S QL + QE L++E + + + L+ L
Sbjct: 1294 GMLNEAEGKAIKLAKD----------VASLSSQLQDTQELLQEETRQKLNVSTKLRQL-- 1341
Query: 100 NGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKK-------ELLKCKQE 152
EE+ +Q +LD+ ME Q+L++ +L K++
Sbjct: 1342 ----------------------EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 153 ARNLQGIKDALQ----------QRLTQQ-----------DTSVLQLKQELLRANMDKDEL 191
++ +AL+ + LTQQ + + +L+QEL +D D
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 192 HNQNVDLQRKLDERNRLLGEYK----KELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDL 247
+L++K + ++LL E K K ++DR + + K +AL L+ ++
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL-SLARALEEALEA 1498
Query: 248 ERELEHKDVLLAHCMKR--EADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLV 305
+ ELE + +L M+ + + N H + + L T + + +LQ
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 306 RDA-------LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVR 354
DA +++L+ F D Q + E+ L +LH ET+ + ERK R
Sbjct: 1559 EDAKLRLEVNMQALKGQFE-RDLQARD-EQNEEKRRQLQRQLHEYETELEDERKQR 1612
Score = 40.4 bits (93), Expect = 0.004
Identities = 65/287 (22%), Positives = 117/287 (40%), Gaps = 25/287 (8%)
Query: 74 LEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLD 133
LE+ ++E+E KM+ L++ + L + + E Q+ ++++L+
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL--ETQMEEMKTQLE 1549
Query: 134 QSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHN 193
+ +E Q + L+ + N+Q +K ++ L +D + +++L R +LH
Sbjct: 1550 ELEDELQATEDAKLRLEV---NMQALKGQFERDLQARDEQNEEKRRQLQR------QLHE 1600
Query: 194 QNVDLQRKLDERNRLLGEYKKELGQ-KDRLLQQHQA--KLEEALRKLSDVSYHQVDLERE 250
+L+ + +R KK G KD LQ A EEA+++L + D +RE
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 251 LEHKDVLLAHCMKREADEATNYNSHNSQS-NGFLLPTAGKGATSVSNRGTSDLQLVRDAL 309
LE A + E N ++S L+ A + R +DL+ +
Sbjct: 1661 LED-----ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE-KEELA 1714
Query: 310 RSLRNSFSGHDPQHHTIDSLEQGISSLMERLHV----METQKKQERK 352
L +S SG + LE I+ L E L ME + RK
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Score = 38.9 bits (89), Expect = 0.010
Identities = 50/249 (20%), Positives = 106/249 (42%), Gaps = 32/249 (12%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
EE++ + L ++ E Q + EL + +Q+ L K+ LQ++ LQ + EL
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ--------LQAETEL 902
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVS 241
E V L K E +L E + L +++ QQ QA+ ++ +++
Sbjct: 903 YA------EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM---- 952
Query: 242 YHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSD 301
+DLE +LE ++ A K + ++ T + L+ +N+ + +
Sbjct: 953 ---LDLEEQLEEEE---AARQKLQLEKVTAEAKIKKLEDEILV------MDDQNNKLSKE 1000
Query: 302 LQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQ 361
+L+ + + L + + + + + L+ S++ L V ++++ R+ K R
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 362 VG--SEYRE 368
G S++ E
Sbjct: 1061 EGDASDFHE 1069
Score = 36.6 bits (83), Expect = 0.051
Identities = 31/174 (17%), Positives = 81/174 (46%), Gaps = 7/174 (4%)
Query: 80 LEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEEN 139
LE+E+EE + + + + + ++ LA E S Q +N
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE------SARQQLERQN 1794
Query: 140 QDLKKELLKCKQEARN-LQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDL 198
++L+ +L + + ++ + AL+ ++ Q + V Q +E A + + ++
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 199 QRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELE 252
++++ ++ +YK++ + + ++Q + +LEEA + ++ ++ L+REL+
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908
Score = 34.3 bits (77), Expect = 0.25
Identities = 51/239 (21%), Positives = 106/239 (44%), Gaps = 26/239 (10%)
Query: 123 EQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELL 182
E+L +++ L+ +++ ++ K +QE L K AL + + V +++Q+
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVL---KKALDEETRSHEAQVQEMRQKHA 1202
Query: 183 RANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL----S 238
+A + E Q + LD+ + L + +L + R+L Q + ++E +KL
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262
Query: 239 DVSYHQVDLER---ELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVS 295
++ D ER EL K H ++ E + T +++ G + A K S+S
Sbjct: 1263 ELQSKCSDGERARAELNDK----VHKLQNEVESVTGM---LNEAEGKAIKLA-KDVASLS 1314
Query: 296 NRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERL-HVMETQKKQERKV 353
++ +L+++ R N + + LE+ +SL ++L ME ++ ER +
Sbjct: 1315 SQLQDTQELLQEETRQKLNVST-------KLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366
Score = 32.3 bits (72), Expect = 0.96
Identities = 40/201 (19%), Positives = 84/201 (41%), Gaps = 9/201 (4%)
Query: 41 IENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLN 100
+E R + L+ + T L+ E + E + L+KE E++++ + L+ L
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEG 1062
Query: 101 GSLPEDEQERPLA-----LCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARN 155
+ EQ L L EE+L +RLD + + + K++ + + +
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 156 LQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKE 215
LQ D+ + + + L +EL + ++ + Q +R + + KK
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 216 LGQKDRLLQQHQAKLEEALRK 236
L ++ R H+A+++E +K
Sbjct: 1183 LDEETR---SHEAQVQEMRQK 1200
Score = 30.4 bits (67), Expect = 3.6
Identities = 33/164 (20%), Positives = 75/164 (45%), Gaps = 18/164 (10%)
Query: 66 ETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQL 125
E S ++ ++ LE++ +E + + ++ + + + + +A E + E+
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAV------KSKFKSTIAALEAKIAQLEEQ 1829
Query: 126 IIIQSRLDQSM-----EENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
+ ++R Q+ ++++ LK+ LL+ + E + + K+ ++ + V QLK++
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG----NARVKQLKRQ 1885
Query: 181 LLRANMDKDELHNQNVDLQRKLD---ERNRLLGEYKKELGQKDR 221
L A + ++ LQR+LD E N +G L K R
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 52.4 bits (124), Expect = 9e-07
Identities = 50/218 (22%), Positives = 100/218 (45%), Gaps = 22/218 (10%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP------EE 123
E +L E+++ ++ E KKM Q L L L E+E R E E+
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQ--QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 992
Query: 124 QLIIIQSRLDQSMEENQ-------DLKKELLKCKQEARNLQGIKDA-------LQQRLTQ 169
+++++ + ++ +E + DL L + +++A+NL +K+ L+ RL +
Sbjct: 993 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 170 QDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAK 229
++ S +L++ + D + H Q DLQ ++ E L + ++EL L A+
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112
Query: 230 LEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREAD 267
AL+K+ ++ H DL+ +L+ + K++ D
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Score = 43.9 bits (102), Expect = 3e-04
Identities = 78/356 (21%), Positives = 142/356 (39%), Gaps = 78/356 (21%)
Query: 40 GIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLL 99
G+ N EG L++D S QL + QE L++E + + + L+ L
Sbjct: 1301 GMLNEAEGKAIKLAKD----------VASLSSQLQDTQELLQEETRQKLNVSTKLRQL-- 1348
Query: 100 NGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKK-------ELLKCKQE 152
EE+ +Q +LD+ ME Q+L++ +L K++
Sbjct: 1349 ----------------------EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 153 ARNLQGIKDALQ----------QRLTQQ-----------DTSVLQLKQELLRANMDKDEL 191
++ +AL+ + LTQQ + + +L+QEL +D D
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 192 HNQNVDLQRKLDERNRLLGEYK----KELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDL 247
+L++K + ++LL E K K ++DR + + K +AL L+ ++
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL-SLARALEEALEA 1505
Query: 248 ERELEHKDVLLAHCMKR--EADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLV 305
+ ELE + +L M+ + + N H + + L T + + +LQ
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 306 RDA-------LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVR 354
DA +++L+ F D Q + E+ L +LH ET+ + ERK R
Sbjct: 1566 EDAKLRLEVNMQALKGQFE-RDLQARD-EQNEEKRRQLQRQLHEYETELEDERKQR 1619
Score = 40.4 bits (93), Expect = 0.004
Identities = 65/287 (22%), Positives = 117/287 (40%), Gaps = 25/287 (8%)
Query: 74 LEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLD 133
LE+ ++E+E KM+ L++ + L + + E Q+ ++++L+
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL--ETQMEEMKTQLE 1556
Query: 134 QSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHN 193
+ +E Q + L+ + N+Q +K ++ L +D + +++L R +LH
Sbjct: 1557 ELEDELQATEDAKLRLEV---NMQALKGQFERDLQARDEQNEEKRRQLQR------QLHE 1607
Query: 194 QNVDLQRKLDERNRLLGEYKKELGQ-KDRLLQQHQA--KLEEALRKLSDVSYHQVDLERE 250
+L+ + +R KK G KD LQ A EEA+++L + D +RE
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 251 LEHKDVLLAHCMKREADEATNYNSHNSQS-NGFLLPTAGKGATSVSNRGTSDLQLVRDAL 309
LE A + E N ++S L+ A + R +DL+ +
Sbjct: 1668 LED-----ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE-KEELA 1721
Query: 310 RSLRNSFSGHDPQHHTIDSLEQGISSLMERLHV----METQKKQERK 352
L +S SG + LE I+ L E L ME + RK
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Score = 38.9 bits (89), Expect = 0.010
Identities = 50/249 (20%), Positives = 106/249 (42%), Gaps = 32/249 (12%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
EE++ + L ++ E Q + EL + +Q+ L K+ LQ++ LQ + EL
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ--------LQAETEL 909
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVS 241
E V L K E +L E + L +++ QQ QA+ ++ +++
Sbjct: 910 YA------EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM---- 959
Query: 242 YHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSD 301
+DLE +LE ++ A K + ++ T + L+ +N+ + +
Sbjct: 960 ---LDLEEQLEEEE---AARQKLQLEKVTAEAKIKKLEDEILV------MDDQNNKLSKE 1007
Query: 302 LQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQ 361
+L+ + + L + + + + + L+ S++ L V ++++ R+ K R
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 362 VG--SEYRE 368
G S++ E
Sbjct: 1068 EGDASDFHE 1076
Score = 36.6 bits (83), Expect = 0.051
Identities = 31/174 (17%), Positives = 81/174 (46%), Gaps = 7/174 (4%)
Query: 80 LEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEEN 139
LE+E+EE + + + + + ++ LA E S Q +N
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE------SARQQLERQN 1801
Query: 140 QDLKKELLKCKQEARN-LQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDL 198
++L+ +L + + ++ + AL+ ++ Q + V Q +E A + + ++
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 199 QRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELE 252
++++ ++ +YK++ + + ++Q + +LEEA + ++ ++ L+REL+
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915
Score = 34.3 bits (77), Expect = 0.25
Identities = 51/239 (21%), Positives = 106/239 (44%), Gaps = 26/239 (10%)
Query: 123 EQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELL 182
E+L +++ L+ +++ ++ K +QE L K AL + + V +++Q+
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVL---KKALDEETRSHEAQVQEMRQKHA 1209
Query: 183 RANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL----S 238
+A + E Q + LD+ + L + +L + R+L Q + ++E +KL
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269
Query: 239 DVSYHQVDLER---ELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVS 295
++ D ER EL K H ++ E + T +++ G + A K S+S
Sbjct: 1270 ELQSKCSDGERARAELNDK----VHKLQNEVESVTGM---LNEAEGKAIKLA-KDVASLS 1321
Query: 296 NRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERL-HVMETQKKQERKV 353
++ +L+++ R N + + LE+ +SL ++L ME ++ ER +
Sbjct: 1322 SQLQDTQELLQEETRQKLNVST-------KLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373
Score = 32.3 bits (72), Expect = 0.96
Identities = 40/201 (19%), Positives = 84/201 (41%), Gaps = 9/201 (4%)
Query: 41 IENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLN 100
+E R + L+ + T L+ E + E + L+KE E++++ + L+ L
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEG 1069
Query: 101 GSLPEDEQERPLA-----LCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARN 155
+ EQ L L EE+L +RLD + + + K++ + + +
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 156 LQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKE 215
LQ D+ + + + L +EL + ++ + Q +R + + KK
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 216 LGQKDRLLQQHQAKLEEALRK 236
L ++ R H+A+++E +K
Sbjct: 1190 LDEETR---SHEAQVQEMRQK 1207
Score = 30.4 bits (67), Expect = 3.6
Identities = 33/164 (20%), Positives = 75/164 (45%), Gaps = 18/164 (10%)
Query: 66 ETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQL 125
E S ++ ++ LE++ +E + + ++ + + + + +A E + E+
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAV------KSKFKSTIAALEAKIAQLEEQ 1836
Query: 126 IIIQSRLDQSM-----EENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
+ ++R Q+ ++++ LK+ LL+ + E + + K+ ++ + V QLK++
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG----NARVKQLKRQ 1892
Query: 181 LLRANMDKDELHNQNVDLQRKLD---ERNRLLGEYKKELGQKDR 221
L A + ++ LQR+LD E N +G L K R
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 52.4 bits (124), Expect = 9e-07
Identities = 50/218 (22%), Positives = 100/218 (45%), Gaps = 22/218 (10%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP------EE 123
E +L E+++ ++ E KKM Q L L L E+E R E E+
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQ--QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 992
Query: 124 QLIIIQSRLDQSMEENQ-------DLKKELLKCKQEARNLQGIKDA-------LQQRLTQ 169
+++++ + ++ +E + DL L + +++A+NL +K+ L+ RL +
Sbjct: 993 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 170 QDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAK 229
++ S +L++ + D + H Q DLQ ++ E L + ++EL L A+
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112
Query: 230 LEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREAD 267
AL+K+ ++ H DL+ +L+ + K++ D
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Score = 43.9 bits (102), Expect = 3e-04
Identities = 78/356 (21%), Positives = 142/356 (39%), Gaps = 78/356 (21%)
Query: 40 GIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLL 99
G+ N EG L++D S QL + QE L++E + + + L+ L
Sbjct: 1301 GMLNEAEGKAIKLAKD----------VASLSSQLQDTQELLQEETRQKLNVSTKLRQL-- 1348
Query: 100 NGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKK-------ELLKCKQE 152
EE+ +Q +LD+ ME Q+L++ +L K++
Sbjct: 1349 ----------------------EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 153 ARNLQGIKDALQ----------QRLTQQ-----------DTSVLQLKQELLRANMDKDEL 191
++ +AL+ + LTQQ + + +L+QEL +D D
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 192 HNQNVDLQRKLDERNRLLGEYK----KELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDL 247
+L++K + ++LL E K K ++DR + + K +AL L+ ++
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL-SLARALEEALEA 1505
Query: 248 ERELEHKDVLLAHCMKR--EADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLV 305
+ ELE + +L M+ + + N H + + L T + + +LQ
Sbjct: 1506 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1565
Query: 306 RDA-------LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVR 354
DA +++L+ F D Q + E+ L +LH ET+ + ERK R
Sbjct: 1566 EDAKLRLEVNMQALKGQFE-RDLQARD-EQNEEKRRQLQRQLHEYETELEDERKQR 1619
Score = 40.4 bits (93), Expect = 0.004
Identities = 65/287 (22%), Positives = 117/287 (40%), Gaps = 25/287 (8%)
Query: 74 LEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLD 133
LE+ ++E+E KM+ L++ + L + + E Q+ ++++L+
Sbjct: 1499 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL--ETQMEEMKTQLE 1556
Query: 134 QSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHN 193
+ +E Q + L+ + N+Q +K ++ L +D + +++L R +LH
Sbjct: 1557 ELEDELQATEDAKLRLEV---NMQALKGQFERDLQARDEQNEEKRRQLQR------QLHE 1607
Query: 194 QNVDLQRKLDERNRLLGEYKKELGQ-KDRLLQQHQA--KLEEALRKLSDVSYHQVDLERE 250
+L+ + +R KK G KD LQ A EEA+++L + D +RE
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1667
Query: 251 LEHKDVLLAHCMKREADEATNYNSHNSQS-NGFLLPTAGKGATSVSNRGTSDLQLVRDAL 309
LE A + E N ++S L+ A + R +DL+ +
Sbjct: 1668 LED-----ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE-KEELA 1721
Query: 310 RSLRNSFSGHDPQHHTIDSLEQGISSLMERLHV----METQKKQERK 352
L +S SG + LE I+ L E L ME + RK
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Score = 38.9 bits (89), Expect = 0.010
Identities = 50/249 (20%), Positives = 106/249 (42%), Gaps = 32/249 (12%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
EE++ + L ++ E Q + EL + +Q+ L K+ LQ++ LQ + EL
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ--------LQAETEL 909
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVS 241
E V L K E +L E + L +++ QQ QA+ ++ +++
Sbjct: 910 YA------EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM---- 959
Query: 242 YHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSD 301
+DLE +LE ++ A K + ++ T + L+ +N+ + +
Sbjct: 960 ---LDLEEQLEEEE---AARQKLQLEKVTAEAKIKKLEDEILV------MDDQNNKLSKE 1007
Query: 302 LQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQ 361
+L+ + + L + + + + + L+ S++ L V ++++ R+ K R
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 362 VG--SEYRE 368
G S++ E
Sbjct: 1068 EGDASDFHE 1076
Score = 36.6 bits (83), Expect = 0.051
Identities = 31/174 (17%), Positives = 81/174 (46%), Gaps = 7/174 (4%)
Query: 80 LEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEEN 139
LE+E+EE + + + + + ++ LA E S Q +N
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE------SARQQLERQN 1801
Query: 140 QDLKKELLKCKQEARN-LQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDL 198
++L+ +L + + ++ + AL+ ++ Q + V Q +E A + + ++
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1861
Query: 199 QRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELE 252
++++ ++ +YK++ + + ++Q + +LEEA + ++ ++ L+REL+
Sbjct: 1862 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915
Score = 34.3 bits (77), Expect = 0.25
Identities = 51/239 (21%), Positives = 106/239 (44%), Gaps = 26/239 (10%)
Query: 123 EQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELL 182
E+L +++ L+ +++ ++ K +QE L K AL + + V +++Q+
Sbjct: 1153 EELEALKTELEDTLDSTATQQELRAKREQEVTVL---KKALDEETRSHEAQVQEMRQKHA 1209
Query: 183 RANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL----S 238
+A + E Q + LD+ + L + +L + R+L Q + ++E +KL
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1269
Query: 239 DVSYHQVDLER---ELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVS 295
++ D ER EL K H ++ E + T +++ G + A K S+S
Sbjct: 1270 ELQSKCSDGERARAELNDK----VHKLQNEVESVTGM---LNEAEGKAIKLA-KDVASLS 1321
Query: 296 NRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERL-HVMETQKKQERKV 353
++ +L+++ R N + + LE+ +SL ++L ME ++ ER +
Sbjct: 1322 SQLQDTQELLQEETRQKLNVST-------KLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373
Score = 32.3 bits (72), Expect = 0.96
Identities = 40/201 (19%), Positives = 84/201 (41%), Gaps = 9/201 (4%)
Query: 41 IENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLN 100
+E R + L+ + T L+ E + E + L+KE E++++ + L+ L
Sbjct: 1011 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEG 1069
Query: 101 GSLPEDEQERPLA-----LCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARN 155
+ EQ L L EE+L +RLD + + + K++ + + +
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 156 LQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKE 215
LQ D+ + + + L +EL + ++ + Q +R + + KK
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 216 LGQKDRLLQQHQAKLEEALRK 236
L ++ R H+A+++E +K
Sbjct: 1190 LDEETR---SHEAQVQEMRQK 1207
Score = 30.4 bits (67), Expect = 3.6
Identities = 33/164 (20%), Positives = 75/164 (45%), Gaps = 18/164 (10%)
Query: 66 ETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQL 125
E S ++ ++ LE++ +E + + ++ + + + + +A E + E+
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAV------KSKFKSTIAALEAKIAQLEEQ 1836
Query: 126 IIIQSRLDQSM-----EENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
+ ++R Q+ ++++ LK+ LL+ + E + + K+ ++ + V QLK++
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG----NARVKQLKRQ 1892
Query: 181 LLRANMDKDELHNQNVDLQRKLD---ERNRLLGEYKKELGQKDR 221
L A + ++ LQR+LD E N +G L K R
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 52.4 bits (124), Expect = 9e-07
Identities = 50/218 (22%), Positives = 100/218 (45%), Gaps = 22/218 (10%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP------EE 123
E +L E+++ ++ E KKM Q L L L E+E R E E+
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQ--QMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLED 985
Query: 124 QLIIIQSRLDQSMEENQ-------DLKKELLKCKQEARNLQGIKDA-------LQQRLTQ 169
+++++ + ++ +E + DL L + +++A+NL +K+ L+ RL +
Sbjct: 986 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 170 QDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAK 229
++ S +L++ + D + H Q DLQ ++ E L + ++EL L A+
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105
Query: 230 LEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREAD 267
AL+K+ ++ H DL+ +L+ + K++ D
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Score = 43.9 bits (102), Expect = 3e-04
Identities = 78/356 (21%), Positives = 142/356 (39%), Gaps = 78/356 (21%)
Query: 40 GIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLL 99
G+ N EG L++D S QL + QE L++E + + + L+ L
Sbjct: 1294 GMLNEAEGKAIKLAKD----------VASLSSQLQDTQELLQEETRQKLNVSTKLRQL-- 1341
Query: 100 NGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKK-------ELLKCKQE 152
EE+ +Q +LD+ ME Q+L++ +L K++
Sbjct: 1342 ----------------------EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 153 ARNLQGIKDALQ----------QRLTQQ-----------DTSVLQLKQELLRANMDKDEL 191
++ +AL+ + LTQQ + + +L+QEL +D D
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 192 HNQNVDLQRKLDERNRLLGEYK----KELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDL 247
+L++K + ++LL E K K ++DR + + K +AL L+ ++
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL-SLARALEEALEA 1498
Query: 248 ERELEHKDVLLAHCMKR--EADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLV 305
+ ELE + +L M+ + + N H + + L T + + +LQ
Sbjct: 1499 KEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQAT 1558
Query: 306 RDA-------LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVR 354
DA +++L+ F D Q + E+ L +LH ET+ + ERK R
Sbjct: 1559 EDAKLRLEVNMQALKGQFE-RDLQARD-EQNEEKRRQLQRQLHEYETELEDERKQR 1612
Score = 40.4 bits (93), Expect = 0.004
Identities = 65/287 (22%), Positives = 117/287 (40%), Gaps = 25/287 (8%)
Query: 74 LEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLD 133
LE+ ++E+E KM+ L++ + L + + E Q+ ++++L+
Sbjct: 1492 LEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRAL--ETQMEEMKTQLE 1549
Query: 134 QSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHN 193
+ +E Q + L+ + N+Q +K ++ L +D + +++L R +LH
Sbjct: 1550 ELEDELQATEDAKLRLEV---NMQALKGQFERDLQARDEQNEEKRRQLQR------QLHE 1600
Query: 194 QNVDLQRKLDERNRLLGEYKKELGQ-KDRLLQQHQA--KLEEALRKLSDVSYHQVDLERE 250
+L+ + +R KK G KD LQ A EEA+++L + D +RE
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRE 1660
Query: 251 LEHKDVLLAHCMKREADEATNYNSHNSQS-NGFLLPTAGKGATSVSNRGTSDLQLVRDAL 309
LE A + E N ++S L+ A + R +DL+ +
Sbjct: 1661 LED-----ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE-KEELA 1714
Query: 310 RSLRNSFSGHDPQHHTIDSLEQGISSLMERLHV----METQKKQERK 352
L +S SG + LE I+ L E L ME + RK
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Score = 38.9 bits (89), Expect = 0.010
Identities = 50/249 (20%), Positives = 106/249 (42%), Gaps = 32/249 (12%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
EE++ + L ++ E Q + EL + +Q+ L K+ LQ++ LQ + EL
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ--------LQAETEL 902
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVS 241
E V L K E +L E + L +++ QQ QA+ ++ +++
Sbjct: 903 YA------EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQM---- 952
Query: 242 YHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSD 301
+DLE +LE ++ A K + ++ T + L+ +N+ + +
Sbjct: 953 ---LDLEEQLEEEE---AARQKLQLEKVTAEAKIKKLEDEILV------MDDQNNKLSKE 1000
Query: 302 LQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQ 361
+L+ + + L + + + + + L+ S++ L V ++++ R+ K R
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 362 VG--SEYRE 368
G S++ E
Sbjct: 1061 EGDASDFHE 1069
Score = 36.6 bits (83), Expect = 0.051
Identities = 31/174 (17%), Positives = 81/174 (46%), Gaps = 7/174 (4%)
Query: 80 LEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEEN 139
LE+E+EE + + + + + ++ LA E S Q +N
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE------SARQQLERQN 1794
Query: 140 QDLKKELLKCKQEARN-LQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDL 198
++L+ +L + + ++ + AL+ ++ Q + V Q +E A + + ++
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI 1854
Query: 199 QRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELE 252
++++ ++ +YK++ + + ++Q + +LEEA + ++ ++ L+REL+
Sbjct: 1855 LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908
Score = 34.3 bits (77), Expect = 0.25
Identities = 51/239 (21%), Positives = 106/239 (44%), Gaps = 26/239 (10%)
Query: 123 EQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELL 182
E+L +++ L+ +++ ++ K +QE L K AL + + V +++Q+
Sbjct: 1146 EELEALKTELEDTLDSTATQQELRAKREQEVTVL---KKALDEETRSHEAQVQEMRQKHA 1202
Query: 183 RANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL----S 238
+A + E Q + LD+ + L + +L + R+L Q + ++E +KL
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ 1262
Query: 239 DVSYHQVDLER---ELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVS 295
++ D ER EL K H ++ E + T +++ G + A K S+S
Sbjct: 1263 ELQSKCSDGERARAELNDK----VHKLQNEVESVTGM---LNEAEGKAIKLA-KDVASLS 1314
Query: 296 NRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERL-HVMETQKKQERKV 353
++ +L+++ R N + + LE+ +SL ++L ME ++ ER +
Sbjct: 1315 SQLQDTQELLQEETRQKLNVST-------KLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366
Score = 32.3 bits (72), Expect = 0.96
Identities = 40/201 (19%), Positives = 84/201 (41%), Gaps = 9/201 (4%)
Query: 41 IENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLN 100
+E R + L+ + T L+ E + E + L+KE E++++ + L+ L
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE-EKSRQELEKLKRKLEG 1062
Query: 101 GSLPEDEQERPLA-----LCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARN 155
+ EQ L L EE+L +RLD + + + K++ + + +
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 156 LQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKE 215
LQ D+ + + + L +EL + ++ + Q +R + + KK
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 216 LGQKDRLLQQHQAKLEEALRK 236
L ++ R H+A+++E +K
Sbjct: 1183 LDEETR---SHEAQVQEMRQK 1200
Score = 30.4 bits (67), Expect = 3.6
Identities = 33/164 (20%), Positives = 75/164 (45%), Gaps = 18/164 (10%)
Query: 66 ETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQL 125
E S ++ ++ LE++ +E + + ++ + + + + +A E + E+
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAV------KSKFKSTIAALEAKIAQLEEQ 1829
Query: 126 IIIQSRLDQSM-----EENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
+ ++R Q+ ++++ LK+ LL+ + E + + K+ ++ + V QLK++
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG----NARVKQLKRQ 1885
Query: 181 LLRANMDKDELHNQNVDLQRKLD---ERNRLLGEYKKELGQKDR 221
L A + ++ LQR+LD E N +G L K R
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 52.0 bits (123), Expect = 1e-06
Identities = 46/191 (24%), Positives = 94/191 (49%), Gaps = 15/191 (7%)
Query: 66 ETSWEEQLLEQQEYLEKEMEEAKKMIS--GLQALLLNGSLPEDEQERPLALCEPGVNPEE 123
+T E L ++Q+Y + E + ++ +S +QA L L + + L+ E ++
Sbjct: 305 QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR-- 362
Query: 124 QLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLR 183
I L + E Q LK+EL + + + ++L+ LQQ+ +++ LQL+ E+
Sbjct: 363 ----IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI-- 416
Query: 184 ANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYH 243
++LH++ ++ +R+L E + L E ++ +K +Q A L+ L +L +
Sbjct: 417 -----NQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKE 471
Query: 244 QVDLERELEHK 254
+V EL+H+
Sbjct: 472 KVTNSTELQHQ 482
Score = 46.6 bits (109), Expect = 5e-05
Identities = 64/309 (20%), Positives = 126/309 (40%), Gaps = 28/309 (9%)
Query: 65 LETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQ 124
++T + LE++ EK +E KK+ S Q ++ + E E V +E
Sbjct: 233 VQTLMDNMTLERERESEKLKDECKKLQS--QYASSEATISQLRSELAKGPQEVAVYVQE- 289
Query: 125 LIIIQSRLDQSMEENQDLKKELLKCKQEARNLQG-------IKDALQQRLTQQDTSVLQL 177
L ++S +++ ++NQ L + LLK +Q+ L+ K +Q L Q+D QL
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 178 KQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL 237
+ R + + LH +V+L K + +L K+EL + + Q +A+ ++ ++
Sbjct: 350 QS---RLSASETSLHRIHVELSEKGEATQKL----KEELSEVETKYQHLKAEFKQLQQQR 402
Query: 238 SDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNR 297
+ H + L+ E+ L ++ + S+ L+ +
Sbjct: 403 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMD---------KEQ 453
Query: 298 GTSDLQLVRDAL-RSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVK 356
+DLQL L L+ + H +D +Q + L T K +E + ++
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQE-QQALQQSTTAKLREAQNDLE 512
Query: 357 SPRTQVGSE 365
Q+G +
Sbjct: 513 QVLRQIGDK 521
Score = 45.4 bits (106), Expect = 1e-04
Identities = 68/313 (21%), Positives = 137/313 (43%), Gaps = 50/313 (15%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLL---------NGSLPEDEQERPLALCEPGVNP 121
+QL +Q+E E+ + + I+ L + LL +G L E Q E ++
Sbjct: 396 KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ----LSSEKLMDK 451
Query: 122 EEQLIIIQ---SRLDQSMEE----NQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSV 174
E+Q+ +Q SRL++ ++E + +L+ +L K KQ+ + Q ++ + +L + +
Sbjct: 452 EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL 511
Query: 175 LQLKQELLRANMDKDE-LHNQNVDLQRKLD-------ERNRLLGEYK---------KELG 217
+++LR DKD+ + N LQ+ + ER L + + +L
Sbjct: 512 ----EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQ 567
Query: 218 QKDRLLQQHQAKLEEALRKLSDV-SYHQVDLERELEHKDVLLAHCMKREADEATNYNSHN 276
+K+ LQ+ +L E L+ S+ Q +L +++ + L R T+ N N
Sbjct: 568 EKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELN 627
Query: 277 SQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSL 336
SQ N + + ++L L +A ++ + + D Q+H +D+ + +
Sbjct: 628 SQLNE---SKEKVSQLDIQIKAKTELLLSAEAAKTAQRA----DLQNH-LDTAQNALQDK 679
Query: 337 MERLHVMETQKKQ 349
+ L+ + TQ Q
Sbjct: 680 QQELNKITTQLDQ 692
Score = 40.4 bits (93), Expect = 0.004
Identities = 46/217 (21%), Positives = 86/217 (39%), Gaps = 23/217 (10%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
E+QL L++ E+ KK I LQ L L + E E L Q
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKL----------------Q 997
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKD 189
+L Q+ +E K+++ + Q LQ +++ +L +Q+L
Sbjct: 998 QQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLS 1057
Query: 190 ELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLER 249
+ + ++ +N+L+ E K ++ + + +L+E + L D+ + E+
Sbjct: 1058 LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEK 1117
Query: 250 ELEHKDVLLAHCMK---READEATNYN----SHNSQS 279
EL ++ LA + R+ E T N SH +S
Sbjct: 1118 ELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154
Score = 40.0 bits (92), Expect = 0.005
Identities = 62/243 (25%), Positives = 95/243 (39%), Gaps = 40/243 (16%)
Query: 65 LETSWEEQLLEQQEYLE---KEMEEAKKMISGLQALLL----NGSLPEDEQERPLALCEP 117
L+ S +L E Q LE +++ + + I L+ALL N SL E E+E A +
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 118 GVNPEEQLIIIQSR----LDQSMEENQDLKKELLKCKQEARNLQGIKD-------ALQQR 166
G L +Q + +Q + + LK + KQ NL A Q R
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 167 LTQQDTSVLQLKQELLRANMDKDELH------------------NQNVDLQRKLDERNRL 208
+ +TSV +L +L + +L Q DLQ LD
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 209 LGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERE---LEHK-DVLLAHCMKR 264
L + ++EL + L Q AKL++ S + H + + + LE K + L K
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
Query: 265 EAD 267
EAD
Sbjct: 736 EAD 738
Score = 39.3 bits (90), Expect = 0.008
Identities = 67/305 (21%), Positives = 133/305 (43%), Gaps = 22/305 (7%)
Query: 65 LETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQ----ERPLALCEPGVN 120
LETS E + E EK + + I LLL+ + Q + L + +
Sbjct: 619 LETSVNELNSQLNESKEK-VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQ 677
Query: 121 PEEQ-LIIIQSRLDQSMEENQD-------LKKELLKCKQEARNLQGIKDALQQRLTQQDT 172
++Q L I ++LDQ + QD L+ L + K++ +L+ + L+ ++ + +
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737
Query: 173 SVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRL-LQQHQAKLE 231
L++K +A D + N DL+ + E ++ L E +KE+ RL LQ+ LE
Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL-EMEKEIVSSTRLDLQKKSEALE 796
Query: 232 EALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGA 291
+KL+ + L+++ E L+ K + +E N + + + +
Sbjct: 797 SIKQKLTKQEEEKQILKQDFE----TLSQETKIQHEELNN-RIQTTVTELQKVKMEKEAL 851
Query: 292 TSVSNRGTSDLQLVRDALRSLRNSFSGHDPQ-HHTIDSLEQGISSLMERLHV-METQKKQ 349
+ + L V D+L++ ++ F + + I LE+ L +L V ME K+
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 350 ERKVR 354
+++++
Sbjct: 912 QKELK 916
Score = 38.1 bits (87), Expect = 0.017
Identities = 61/249 (24%), Positives = 111/249 (44%), Gaps = 36/249 (14%)
Query: 76 QQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQS 135
+Q+ +KE ++ ++ LQ + SL E E VN + +L I+ +
Sbjct: 1088 EQDSAKKE-QQLQERCKALQDIQKEKSLKEKEL----------VNEKSKLAEIEEIKCRQ 1136
Query: 136 MEE----NQDLKKELLKCKQEARNLQGIKDAL-QQRLTQQ---DTSVLQLKQELLRANMD 187
+E N++LK L+ +E NL+ K L QQ+L Q D+ ++QE +
Sbjct: 1137 EKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL 1196
Query: 188 KDELHNQNVDLQRKLDERN-RLLGEYK-KELGQKDRLLQQHQAKLEEALRKLSDVSYHQV 245
KD++ + +L+++ E+ +L E K KE+G K ++++AKL + L++ +
Sbjct: 1197 KDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKH--EENEAKLTMQITALNE---NLG 1251
Query: 246 DLERELEHKDVLLAHCMKREAD--------EATNYNSHNSQSNGFLLPTAGKGATSVSNR 297
+++E + ++ K+ D EAT N N LL KG +
Sbjct: 1252 TVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN--NQDERRALLERCLKGEGEIEKL 1309
Query: 298 GTSDLQLVR 306
T L+L R
Sbjct: 1310 QTKVLELQR 1318
Score = 35.8 bits (81), Expect = 0.087
Identities = 36/161 (22%), Positives = 73/161 (45%), Gaps = 22/161 (13%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLN-------GSLPEDEQERPLALCEPGVNPEE 123
+Q+L+ Q ++KE EE KK +A L + G +E E L +
Sbjct: 1193 QQILKDQ--VKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM--------- 1241
Query: 124 QLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLR 183
Q+ + L +E Q ++ + + +++ +L+G L+ + L + L+
Sbjct: 1242 QITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLK 1301
Query: 184 ANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQ 224
+ ++L + ++LQRKLD + +ELG++++ LQ
Sbjct: 1302 GEGEIEKLQTKVLELQRKLDNTTAAV----QELGRENQSLQ 1338
Score = 31.2 bits (69), Expect = 2.1
Identities = 39/207 (18%), Positives = 86/207 (41%), Gaps = 13/207 (6%)
Query: 66 ETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQL 125
+T E +L +Q +E+ K+ IS LQ + E QE L E +L
Sbjct: 989 KTELENKLQQQLTQAAQELAAEKEKISVLQ------NNYEKSQETFKQLQSDFYGRESEL 1042
Query: 126 II-------IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLK 178
+ ++ +L + E+ + ++ + + L+ K L+Q +++ + +
Sbjct: 1043 LATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC 1102
Query: 179 QELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLS 238
+ L +K + V+ + KL E + +KE+ + + L+ H+ + + + L
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLK 1162
Query: 239 DVSYHQVDLERELEHKDVLLAHCMKRE 265
D + + EL+ K L +++E
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQE 1189
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 52.0 bits (123), Expect = 1e-06
Identities = 58/309 (18%), Positives = 144/309 (46%), Gaps = 36/309 (11%)
Query: 73 LLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRL 132
L ++ E L++++ + K ++ L+ + + + LA E ++ +E+ II+
Sbjct: 544 LQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKER--IIERLK 601
Query: 133 DQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQ---ELLRANMDKD 189
+Q ++++ +E+ ++E ++L+ +ALQ LT++++S++ LK+ L A + +D
Sbjct: 602 EQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRD 661
Query: 190 -ELHNQNVDLQRKLDERNRLLGEYKK----------------ELGQKDRLLQQH------ 226
+L + + +++K +E ++L + KK ++ Q D+ +
Sbjct: 662 SKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGK 721
Query: 227 -QAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQ----SNG 281
QA+++ L L +V + D ++++ + L MK + + N HN Q N
Sbjct: 722 AQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANL-KHNQQLEKKKNA 780
Query: 282 FLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLH 341
LL + S+++ + LQ + + + +L + D + S +Q ++ L
Sbjct: 781 QLLEEVRRREDSMAD-NSQHLQ-IEELMNALEKTRQELDATKARLASTQQSLAEKEAHLA 838
Query: 342 VMETQKKQE 350
+ +++++
Sbjct: 839 NLRIERRKQ 847
Score = 50.4 bits (119), Expect = 3e-06
Identities = 89/401 (22%), Positives = 162/401 (40%), Gaps = 61/401 (15%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
E ++ Q++ L E KK++ LQ+ L ED+ ER + E E Q+ ++
Sbjct: 288 ELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAE----AESQVSHLE 343
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQ---------E 180
LDQ +EN L++EL + Q K ALQ + +DT + L++ +
Sbjct: 344 VILDQKEKENIHLREELHRRSQLQPEPAKTK-ALQTVIEMKDTKIASLERNIRDLEDEIQ 402
Query: 181 LLRAN-----MDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALR 235
+L+AN D++E Q + + + K+EL +K+ L Q KLE
Sbjct: 403 MLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSN 462
Query: 236 KLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVS 295
+ SD H L+ L K+ A ++ E D + FL +
Sbjct: 463 QNSDCKQHIEVLKESLTAKEQRAA-ILQTEVDA---LRLRLEEKESFLNKKTKQLQDLTE 518
Query: 296 NRGT--SDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKV 353
+GT +++ ++D L + + I+ L++ I +L E+L + Q K
Sbjct: 519 EKGTLAGEIRDMKDML----------EVKERKINVLQKKIENLQEQLRDKDKQ-LTNLKD 567
Query: 354 RVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEE 413
RVKS +T S ++ T +T + L +R I +RL+E
Sbjct: 568 RVKSLQTD-----------------SSNTDTALATLEEALSEKER--------IIERLKE 602
Query: 414 VTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAI 454
+D + ++ + R K L + ++ E+ + ++
Sbjct: 603 QRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSL 643
Score = 38.5 bits (88), Expect = 0.013
Identities = 40/174 (22%), Positives = 78/174 (44%), Gaps = 22/174 (12%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
E ++ ++Q +++ E+ +D K+L K ++LQ + DT++ L++ L
Sbjct: 538 ERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDS-------SNTDTALATLEEAL 590
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRL--LGEYKKELGQKDRLLQQHQAKLEEALRKLSD 239
+ E + + QR+ D+R RL + ++KE + QA+L E L D
Sbjct: 591 -----SEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLID 645
Query: 240 VSYH-----QVDLERELEHKDVLLAHCMKREAD---EATNYNSHNSQSNGFLLP 285
+ H L+R+ + K + +A K+E EA +HN + + + P
Sbjct: 646 LKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNP 699
Score = 38.1 bits (87), Expect = 0.017
Identities = 44/198 (22%), Positives = 94/198 (47%), Gaps = 16/198 (8%)
Query: 71 EQLLEQQEYLEKEME-EAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
++L + + L KE++ + K+ S + ++ S PE ++ER L E ++ +++
Sbjct: 155 KELQRENDLLRKELDIKDSKLGSSMNSIKTFWS-PELKKERVLRKEEAA-----RMSVLK 208
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTS--VLQLKQELLRANMD 187
++ S EENQ L+ + + E R + + LQQ + ++L +E R
Sbjct: 209 EQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQA 268
Query: 188 KDELHNQNVDLQRK-LDERNRLLGEYKKELGQKD----RLLQQHQAK--LEEALRKLSDV 240
+ + + + L RK L+E + K+ L +D +LL+ Q+K ++L ++
Sbjct: 269 EHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNER 328
Query: 241 SYHQVDLERELEHKDVLL 258
+ + E ++ H +V+L
Sbjct: 329 TRRMAEAESQVSHLEVIL 346
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 51.6 bits (122), Expect = 2e-06
Identities = 81/338 (23%), Positives = 144/338 (42%), Gaps = 42/338 (12%)
Query: 65 LETSWEEQLLEQQEYLEKEMEEAKKMIS-------GLQALLLNGSLPEDE--QERPLALC 115
LET E +L + E+ E+ + +++M+ LQ L + + P+ QE P
Sbjct: 127 LETK-ERELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRLPQESPETKS 185
Query: 116 EPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQE-----ARNLQGIKDALQQRLTQQ 170
EPG PE Q ++++ + + ENQ L K+ + +E R + I+ A+QQ ++Q
Sbjct: 186 EPGQGPEMQEVLLE--VQRLRVENQQLSKDYARKAEELQATYERENEAIRQAMQQSVSQA 243
Query: 171 DTSVLQLKQELLRANMDKDE--LHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQA 228
Q K+ LR N E L Q L+ L+ R R + + KK + +Q
Sbjct: 244 -LWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDLKKYAQKLKERIQDLDV 302
Query: 229 KLEEALRKLSDVSYHQVDLERELE-HKD-VLLAHC--------MKRE-ADEATNYNSHNS 277
+L+EA ++ S++ L +L KD ++L C MK E E N
Sbjct: 303 QLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTELVSENKVLREEND 362
Query: 278 QSNGFLLPTAGKGATS--VSNRGTSDLQLVRDALRSLRNSFSGHDP-----QHHTIDSLE 330
G L P + +G +D+Q ++A ++ +H T + +
Sbjct: 363 LEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMKQQYEEDLRKIKHQTEEEKK 422
Query: 331 QGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRE 368
L++RL + ++ V +KS R+ V +E ++
Sbjct: 423 HLKDQLVKRLEDL----VKKHTVEIKSVRSSVEAERKK 456
Score = 41.6 bits (96), Expect = 0.002
Identities = 61/303 (20%), Positives = 116/303 (38%), Gaps = 35/303 (11%)
Query: 52 LSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERP 111
L DW+ + S +Q LEQ +E +A K +S L+ L L E Q+
Sbjct: 594 LEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQETTQQNH 653
Query: 112 LALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQD 171
+ + + L +++ Q ++ ++ K K+ + +LQ Q
Sbjct: 654 AMKAQLEASHQRALRMLEKARHQELKATEERLK-----KESSHSLQ----------IQHQ 698
Query: 172 TSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLE 231
T L+L+ +A + E + +R ++ LL ++EL ++ HQ LE
Sbjct: 699 THRLELQALEEKARQELQE------ERERMQAQQALLLESLRQELSEQQAACSGHQKDLE 752
Query: 232 EALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGA 291
+L + Q + + KD ++A + +A G AG+G+
Sbjct: 753 ALQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQA-----------GSPPGAAGQGS 801
Query: 292 TSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLM--ERLHVMETQKKQ 349
+ QL +DA+R LR H + + + + +R +ET +++
Sbjct: 802 GEGCGLWEENAQL-QDAVRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQRAREVETLRQE 860
Query: 350 ERK 352
RK
Sbjct: 861 HRK 863
>gi|203096856 kinesin family member 7 [Homo sapiens]
Length = 1343
Score = 51.2 bits (121), Expect = 2e-06
Identities = 42/178 (23%), Positives = 83/178 (46%), Gaps = 9/178 (5%)
Query: 54 RDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLA 113
R R GS G+ + ++++ EQ+++L++EME+ + L+ L E+ +R
Sbjct: 889 RKRRSGSNGSVVSLEQQQKIEEQKKWLDQEMEKVLQQRRALE------ELGEELHKREAI 942
Query: 114 LCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTS 173
L + +E+ + RL S N+D+ + + + + L L+Q Q S
Sbjct: 943 LAKKEALMQEKTGLESKRLRSSQALNEDIVRVSSRLEHLEKELSEKSGQLRQGSAQ---S 999
Query: 174 VLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLE 231
Q++ E+ +KD L Q +++ KL + + L E ++ L Q D ++ A +E
Sbjct: 1000 QQQIRGEIDSLRQEKDSLLKQRLEIDGKLRQGSLLSPEEERTLFQLDEAIEALDAAIE 1057
Score = 32.3 bits (72), Expect = 0.96
Identities = 44/188 (23%), Positives = 81/188 (43%), Gaps = 25/188 (13%)
Query: 84 MEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLK 143
++E K+ L +L E ER + L +Q +Q RL + E+ + L+
Sbjct: 800 LKEKKQATERLVSLSAQSEKRLQELERNVQLMR------QQQGQLQRRLREETEQKRRLE 853
Query: 144 KELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDEL---HNQNVDLQR 200
E+ K + + L+ +K QQ++ + T + Q R+ + + Q ++ Q+
Sbjct: 854 AEMSKRQHRVKELE-LKHEQQQKILKIKTEEIAAFQRKRRSGSNGSVVSLEQQQKIEEQK 912
Query: 201 K---------LDERNRL--LGE--YKKE--LGQKDRLLQQHQAKLEEALRKLSDVSYHQV 245
K L +R L LGE +K+E L +K+ L+Q+ + LR ++ V
Sbjct: 913 KWLDQEMEKVLQQRRALEELGEELHKREAILAKKEALMQEKTGLESKRLRSSQALNEDIV 972
Query: 246 DLERELEH 253
+ LEH
Sbjct: 973 RVSSRLEH 980
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 50.8 bits (120), Expect = 3e-06
Identities = 43/208 (20%), Positives = 101/208 (48%), Gaps = 12/208 (5%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGV---NPEEQLI 126
EE+L E++ ++E++E ++ + L+ L E+EQ++ E + EE+
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERRE 316
Query: 127 IIQSRLDQS--MEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRA 184
+ R +Q E+ ++ +++ L+ +QE R Q ++ ++ +Q QL++E
Sbjct: 317 QQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ-----QLRREQEEE 371
Query: 185 NMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQ 244
++ Q + +++L +L E ++L ++ +L ++ Q + E+ LR+ + Q
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRRE--QQLRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 245 VDLERELEHKDVLLAHCMKREADEATNY 272
+ E +H+ +KRE +E ++
Sbjct: 430 EEERHEQKHEQERREQRLKREQEERRDW 457
Score = 42.7 bits (99), Expect = 7e-04
Identities = 47/202 (23%), Positives = 88/202 (43%), Gaps = 21/202 (10%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
+E+ EQQE E++ E ++ + Q E+ +E+ L + E+QL Q
Sbjct: 318 QEERREQQERREQQEERREQQLRREQ---------EERREQQLRREQEEERREQQLRREQ 368
Query: 130 S--RLDQSMEENQDLKKEL-LKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANM 186
R +Q + Q L++E L+ +Q+ R Q ++ Q R QQ QL++E
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 187 DKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVD 246
++E H Q + +R+ R E + L +++ + Q + ++ L++ D
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR---------D 479
Query: 247 LERELEHKDVLLAHCMKREADE 268
E E + + L +RE E
Sbjct: 480 QEEERRERWLKLEEEERREQQE 501
Score = 42.4 bits (98), Expect = 0.001
Identities = 46/215 (21%), Positives = 95/215 (44%), Gaps = 22/215 (10%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
E++ L ++E E+ + ++ LQ L L E+ + L E G+ +++
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE----- 861
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK- 188
R Q +Q + +L + ++ R+ K ALQ++L ++ + + ++EL R +K
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR 921
Query: 189 ----------DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKL-----EEA 233
+E Q + Q +ER + + ++ +KD+ LQQ + +L E+
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981
Query: 234 LRKLSDVSYHQVDLERELEHKDVLLAHCMKREADE 268
R+ + Y + + E + E + +L KR E
Sbjct: 982 RRQEREKKYREEE-ELQQEEEQLLREEREKRRRQE 1015
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/180 (22%), Positives = 84/180 (46%), Gaps = 20/180 (11%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
+Q L ++ L +E EE ++ LL EQER E + E++
Sbjct: 529 QQRLRSEQQLRREQEERREQ------LLKREEEKRLEQERR----EQRLKREQE-----E 573
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDE 190
R DQ ++ ++ +++ LK +QE R Q +K +RL Q++ +LK+E ++E
Sbjct: 574 RRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKRE-----EPEEE 628
Query: 191 LHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERE 250
Q + + + + R + L ++E ++ ++ + +LE+ L++ + + +L E
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Score = 41.2 bits (95), Expect = 0.002
Identities = 52/220 (23%), Positives = 94/220 (42%), Gaps = 38/220 (17%)
Query: 64 YLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEE 123
Y + + +EQL ++Q+ L++E EE ++ + EQER E EE
Sbjct: 890 YAKPALQEQLRKEQQLLQEEEEELQREEREKRR--------RQEQERQYREEEQLQQEEE 941
Query: 124 QLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQR------------LTQQD 171
QL+ + + E + +K+ K +Q+ L G + ++R L Q++
Sbjct: 942 QLLREEREKRRRQERERQYRKDK-KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEE 1000
Query: 172 TSVLQ------LKQELLRANMDKDELHNQNVDL------QRKLDERNRLLGEYKKELGQK 219
+L+ +QE R KDEL + L +R+L ER R E ++ ++
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060
Query: 220 DRLL-----QQHQAKLEEALRKLSDVSYHQVDLERELEHK 254
++LL + + +LE RK ++ + L RE K
Sbjct: 1061 EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Score = 40.8 bits (94), Expect = 0.003
Identities = 52/210 (24%), Positives = 94/210 (44%), Gaps = 23/210 (10%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLL----NGSLPEDEQERPLALCEPGVNPEEQL 125
EEQ L +QE K ++E +++ + L + E+EQ+ + EEQ
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ 1438
Query: 126 IIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRAN 185
+ Q R + +EE Q L++E + +E L ++ Q ++D L+ +Q+L R
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498
Query: 186 MDK----DELHNQNVD---------LQRKLDERNRLLGEY---KKELGQKDRLLQQHQAK 229
D+ EL +Q + L R+ +R L E ++E GQ+ R + + +
Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR 1558
Query: 230 LEEALRKLSD---VSYHQVDLERELEHKDV 256
EE LR+ + +S + D + LE + V
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588
Score = 40.4 bits (93), Expect = 0.004
Identities = 42/210 (20%), Positives = 97/210 (46%), Gaps = 19/210 (9%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
EEQL +++E + +E + L + EQER E + +E ++
Sbjct: 1560 EEQLRQEREEQQLSRQERDRKFR-----LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614
Query: 130 SRLDQSMEENQDL--KKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD 187
D+ E++ L ++E + ++ R+ + +++ Q R +++ QL+ + R +
Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ---QLRHDRDRKFRE 1671
Query: 188 KDELHNQNVDLQRKLDERNRLLGEYKKELGQKDR----LLQQHQAKLEEALRKLSDVSY- 242
+++L + + Q + ER+R E +++L +++R L ++ Q + +E RK +
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 243 ----HQVDLERELEHKDVLLAHCMKREADE 268
Q L R+ ++ +L ++ E +E
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREE 1761
Score = 38.9 bits (89), Expect = 0.010
Identities = 50/213 (23%), Positives = 95/213 (44%), Gaps = 16/213 (7%)
Query: 65 LETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQ 124
L EE+ EQQ E+E E ++ + Q L L ++Q R E + E+Q
Sbjct: 351 LRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR----EQQLRREQQ 406
Query: 125 LIIIQS-RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLR 183
L Q R +Q + Q L++E + + E ++ Q ++ +R ++ L+ ++E R
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER 466
Query: 184 ANMD--KDELHNQNVDLQR----KLDERNRLLGEYKKE--LGQKDRLLQQHQAKLEEALR 235
+ K +L + +R KL+E R + ++E L ++ ++ + K +E
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE 526
Query: 236 KLSDVSYHQVDLERELEHKDVLLAHCMKREADE 268
+L + L RE E + L +KRE ++
Sbjct: 527 RLQQRLRSEQQLRREQEERREQL---LKREEEK 556
Score = 38.9 bits (89), Expect = 0.010
Identities = 48/187 (25%), Positives = 89/187 (47%), Gaps = 16/187 (8%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
EEQ L +QE K +EE ++ + L +E L E EEQ + Q
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEG----EEQQLRRQ 1687
Query: 130 SRLDQSMEENQDLKKE-----LLKCKQEARNLQGIKDALQQRLTQQDTSVLQLK-QELLR 183
R + EE Q L+++ L+ +Q+ R + + ++ +Q+T QL+ QE R
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747
Query: 184 ANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYH 243
+++++L + + Q + ER+R E +++L Q+ ++ Q + +E+ RK +
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFRE-EEQLRQE---REEQQLRSQESDRKFRE--EE 1801
Query: 244 QVDLERE 250
Q+ ERE
Sbjct: 1802 QLRQERE 1808
Score = 38.5 bits (88), Expect = 0.013
Identities = 55/223 (24%), Positives = 100/223 (44%), Gaps = 40/223 (17%)
Query: 70 EEQLLEQQ------EYLEKEMEEAKKMISGLQALLLNGSLPE----DEQERPLALCEPGV 119
EEQLL ++ + E++ + KK+ + LL G PE E+E+ E
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL--GEEPEKRRRQEREKKYREEEELQ 997
Query: 120 NPEEQLIIIQ---------SRLDQSMEENQDLKKELLKCKQEARNLQGIKDAL--QQRLT 168
EEQL+ + R + +E Q +++LL+ ++E R LQ + ++ L
Sbjct: 998 QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ 1057
Query: 169 QQDTSVL------QLKQELLRANMDKDELHNQNVDL------QRKLDERNRLLGEYKKEL 216
Q++ +L + +QEL R ++EL + L +R+ ER R E ++
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQ 1117
Query: 217 GQKDRLLQQHQAK-----LEEALRKLSDVSYHQVDLERELEHK 254
++++LL++ + K LE R+ +V + L RE K
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK 1160
Score = 37.0 bits (84), Expect = 0.039
Identities = 46/207 (22%), Positives = 102/207 (49%), Gaps = 18/207 (8%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
EE+L +++E L E E ++ + L ++E++ L E PE++ +
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ---LLRE---EPEKRRRQER 1106
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDAL--QQRLTQQDTSVLQ------LKQEL 181
R + EE Q +++LL+ ++E R Q ++ ++ + Q++ +L+ +QEL
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL 1166
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVS 241
R +++EL + L R+ E+ R E +++ +++ L +Q + + + SD+
Sbjct: 1167 ERQYREEEELQQEEEQLLREEQEKRR--QERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 242 YHQVDLERELEHKDVLLAHCMKREADE 268
+ Q + E+E +D + +C RE ++
Sbjct: 1225 W-QWEPEKENAVRDNKV-YCKGRENEQ 1249
Score = 36.6 bits (83), Expect = 0.051
Identities = 45/203 (22%), Positives = 90/203 (44%), Gaps = 27/203 (13%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
EQ L +++ L +E EE + + EQER + EE+ ++
Sbjct: 416 EQQLRREQQLRREQEEERHE-------------QKHEQERREQRLKR--EQEERRDWLKR 460
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDE 190
+ E + K++L + ++E R + +K ++R QQ+ QL++E + +
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 191 LHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVD---- 246
+ LQ++L +L E ++ ++++LL++ + K E R+ + Q +
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEE---RREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 247 -LERELEHKDVLLAHCMKREADE 268
L+RE E + L KRE +E
Sbjct: 578 LLKREEERRQQRL----KREQEE 596
Score = 35.4 bits (80), Expect = 0.11
Identities = 41/198 (20%), Positives = 88/198 (44%), Gaps = 23/198 (11%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVN--PEEQLII 127
EEQLL+++E + +E + + L +E+ L EP EEQ +
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 128 IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD 187
Q R + ++E Q L+++ + QQR +D + +E LR +
Sbjct: 1526 RQQRQRKFLQEEQQLRRQ---------------ERGQQRRQDRDRKFRE--EEQLRQERE 1568
Query: 188 KDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDL 247
+ +L Q D + +L+E+ E +++ + ++ L++ + ++ LR+ D + +
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG--QQQLRQERDRKFRED-- 1624
Query: 248 ERELEHKDVLLAHCMKRE 265
E+ L+ ++ H +R+
Sbjct: 1625 EQLLQEREEQQLHRQERD 1642
Score = 34.7 bits (78), Expect = 0.19
Identities = 38/170 (22%), Positives = 80/170 (47%), Gaps = 30/170 (17%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
EEQ L +QE K EE + L ++ +E+ L E E+ + Q
Sbjct: 1760 EEQQLRRQERDRKFREEEQ--------------LRQEREEQQLRSQESDRKFREEEQLRQ 1805
Query: 130 SRLDQSMEENQD-----LKKELLKCKQEARNLQGIKD---------ALQQRLTQQDTSVL 175
R +Q + Q ++E L+ +++ + L+ +D A Q++ +++ +
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELW 1865
Query: 176 QLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQ-KDRLLQ 224
Q +++ R ++ +L +++ Q+K ++R+R +GE K + G+ RLL+
Sbjct: 1866 QEEEQKRRQERER-KLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914
Score = 32.7 bits (73), Expect = 0.73
Identities = 37/189 (19%), Positives = 85/189 (44%), Gaps = 22/189 (11%)
Query: 70 EEQLLEQQEYLE---KEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLI 126
+E+ L ++E LE K EE ++ Q + ++E+E+ E + EE+ +
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVF-----QEEEEKEWRKRETVLRKEEEKL 260
Query: 127 IIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANM 186
EE ++EL + +++ R L+ + +++ +Q L+ +Q+L R
Sbjct: 261 ---------QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311
Query: 187 D-----KDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVS 241
+ ++E Q +++ + R + L ++E ++ +Q + + E+ LR+ +
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Query: 242 YHQVDLERE 250
+ L RE
Sbjct: 372 RREQQLRRE 380
Score = 32.7 bits (73), Expect = 0.73
Identities = 50/211 (23%), Positives = 95/211 (45%), Gaps = 37/211 (17%)
Query: 70 EEQLLEQQ------EYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEE 123
EEQLL ++ + LE++ E +++ + LL +EQE+ E EE
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLL------REEQEKRRQERERQYREEE 1203
Query: 124 QLIIIQSRLDQSMEENQ--DLKKEL------------LKCK-QEARNLQGIKDA-LQQRL 167
+L Q R + +E+Q DLK + + CK +E + ++D+ L+ R
Sbjct: 1204 ELQR-QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262
Query: 168 TQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQ 227
+QQD L +Q+ D+++ + R E +L E +KE ++DR Q+
Sbjct: 1263 SQQDLQHLLGEQQ----ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEE- 1317
Query: 228 AKLEEALRKLSDVSYHQVDLERELEHKDVLL 258
++ LR+ + + + +R+ ++ LL
Sbjct: 1318 ---KQLLREEREEKRRRQETDRKFREEEQLL 1345
Score = 32.7 bits (73), Expect = 0.73
Identities = 35/152 (23%), Positives = 69/152 (45%), Gaps = 8/152 (5%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
E + LE+++ L ++ + +K + Q L + Q+R E EEQL Q
Sbjct: 1514 ERKFLEEEQQLHRQQRQ-RKFLQEEQQLRRQERGQQRRQDRDRKFRE-----EEQLR--Q 1565
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKD 189
R +Q + + +K L+ ++ R Q K ++ ++ QL+QE R + +
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE 1625
Query: 190 ELHNQNVDLQRKLDERNRLLGEYKKELGQKDR 221
+L + + Q ER+R E + +L +++R
Sbjct: 1626 QLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657
>gi|195927059 axin 2 [Homo sapiens]
Length = 843
Score = 50.4 bits (119), Expect = 3e-06
Identities = 24/59 (40%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 410 RLEEVTLKDFKAAIDREGNHRYHFKALDPEF--GTVKEEIFHDDDAIPGWEGKIVAWVE 466
+ + +TL FK + ++GN+RY+FK EF G V EEI+ D+ +P +EG+I+ VE
Sbjct: 782 KAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVE 840
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 50.4 bits (119), Expect = 3e-06
Identities = 33/122 (27%), Positives = 64/122 (52%), Gaps = 3/122 (2%)
Query: 129 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK 188
Q LD ++ +DLK++L ++ A LQ + L+ L Q + S +QELL A+
Sbjct: 1660 QIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1719
Query: 189 DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLE 248
LH QN L ++ + +L + + G+ + +LQ+ + E+A + ++D + +L+
Sbjct: 1720 QLLHTQNTSL---INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK 1776
Query: 249 RE 250
+E
Sbjct: 1777 KE 1778
Score = 41.2 bits (95), Expect = 0.002
Identities = 35/166 (21%), Positives = 81/166 (48%), Gaps = 15/166 (9%)
Query: 124 QLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL-- 181
+L I++ ++S+++ + LK+E +QE +L +R+ + + Q++QE
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 182 LRANMDKDE--LHNQNVDLQRKLDERNRLLGEYKKELGQKD-----------RLLQQHQA 228
L+A +++ E L ++ + R E N++ E +++ +KD R+++ Q+
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 229 KLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNS 274
L+ +R +D + +E +L ++ L H + A+ NY +
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1651
Score = 40.8 bits (94), Expect = 0.003
Identities = 41/197 (20%), Positives = 89/197 (45%), Gaps = 27/197 (13%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
E+ L+Q E L++E + ++ IS L + G E E+ E++ +Q+
Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK------QVEQEKCELQA 1548
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQ------ELLRA 184
L+++ + + ++L+ + E L +K + +++ ++D + QLK+ E +++
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLE---LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 185 NMDKD-ELHNQNVDLQRK-----------LDERNRLLGEYKKELGQKDRLLQQHQAKLEE 232
+D + N + L++K L+ NR+ E + +L+ Q L++
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 233 ALRKLSDVSYHQVDLER 249
ALR D+ +ER
Sbjct: 1666 ALRSQEDLKEQLAMVER 1682
Score = 37.4 bits (85), Expect = 0.030
Identities = 64/325 (19%), Positives = 132/325 (40%), Gaps = 46/325 (14%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
E++ E + K +E K + Q L + ED+ L + + E+Q+
Sbjct: 986 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN---TLTKAKIKLEQQV----D 1038
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDE 190
L+ S+E+ + L+ +L + K R L+G Q+ + + QL ++L + +
Sbjct: 1039 DLEGSLEQEKKLRMDLERAK---RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISN 1095
Query: 191 LHNQ-------NVDLQRKLDERNRLLGEYKKEL---------GQKDRL-LQQHQAKLEEA 233
L ++ + LQ+K+ E + E ++E+ +K R L + ++ E
Sbjct: 1096 LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1155
Query: 234 LRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATS 293
L + + Q+++ ++ E + M+R+ +EAT Q K A S
Sbjct: 1156 LEEAGGATSAQIEMNKKREAE----FQKMRRDLEEAT------LQHEATAATLRKKHADS 1205
Query: 294 VSNRG--TSDLQLVRDALRSLRNSFSGH-DPQHHTIDSLEQGISSLMERLHVMETQ---- 346
V+ G +LQ V+ L ++ D ++++ + +L + +E Q
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265
Query: 347 --KKQERKVRVKSPRTQVGSEYRES 369
K++E++ + Q G ES
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTES 1290
Score = 35.0 bits (79), Expect = 0.15
Identities = 38/179 (21%), Positives = 82/179 (45%), Gaps = 7/179 (3%)
Query: 65 LETSWEEQLLEQQEYLEKEM---EEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP 121
LET + E ++ L++ E+AKK I+ A ++ L + EQ+ L N
Sbjct: 1736 LETDISQMQGEMEDILQEARNAEEKAKKAIT--DAAMMAEELKK-EQDTSAHLERMKKNM 1792
Query: 122 EEQLIIIQSRLDQSME-ENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
E+ + +Q RLD++ + + KK++ K + R L+G ++ Q+R + + + ++
Sbjct: 1793 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERR 1852
Query: 181 LLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSD 239
+ +E + LQ +D+ + YK++ + + + AK + +L +
Sbjct: 1853 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEE 1911
Score = 33.1 bits (74), Expect = 0.56
Identities = 54/263 (20%), Positives = 105/263 (39%), Gaps = 40/263 (15%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
++L + E LE+E+E + S +A L + +E L E G Q+ + +
Sbjct: 1115 KELQARIEELEEEIEAERA--SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1172
Query: 131 RLDQSMEENQDLKKELLKCKQEAR------------------NLQGIKDALQQRLTQQDT 172
R + + +DL++ L+ + A NLQ +K L++ ++
Sbjct: 1173 REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1232
Query: 173 SVLQLKQEL-----LRANMDK--DELHNQNVDLQRKLDERNRLL-------GEYKKELGQ 218
+ L + + N++K L +Q +L+ K +E+ RL+ G + E G+
Sbjct: 1233 EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGE 1292
Query: 219 KDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHK---DVLLAHCM---KREADEATNY 272
R L + +A + + R + +L+R+LE + LAH + + + D
Sbjct: 1293 FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQ 1352
Query: 273 NSHNSQSNGFLLPTAGKGATSVS 295
+S L K T V+
Sbjct: 1353 YEEEQESKAELQRALSKANTEVA 1375
Score = 32.3 bits (72), Expect = 0.96
Identities = 80/342 (23%), Positives = 139/342 (40%), Gaps = 40/342 (11%)
Query: 65 LETSWEEQLLEQQEY--LEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPE 122
LET E QQE L +++ E K I L+ + + E + L E + E
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHE 1560
Query: 123 EQLII-IQSRLDQSMEE-NQDLKKELLKCKQEARNLQGIKDALQQRL-----TQQDTSVL 175
E I+ IQ L+Q E ++ + ++ + Q RN I +++Q L ++ D L
Sbjct: 1561 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 176 QLKQE---------LLRAN-MDKDELHNQN------VDLQRKLDERNRLLGEYKKELGQK 219
+ K E L AN M + L N D Q LD+ R + K++L
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680
Query: 220 DRLLQQHQAKLEEALRKLSDVSYHQVDLEREL--EHKDVLLAHCMKRE-ADEATNYNSHN 276
+R QA++EE L + E+EL + V L H + +
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 277 SQSNGFL--LPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGIS 334
SQ G + + + A + + +D ++ + L+ +++ S H ++EQ +
Sbjct: 1741 SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAH--LERMKKNMEQTVK 1797
Query: 335 SLMERLH-----VMETQKKQERKV--RVKSPRTQVGSEYRES 369
L RL ++ KKQ +K+ RV+ +V SE + +
Sbjct: 1798 DLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1839
Score = 29.3 bits (64), Expect = 8.1
Identities = 41/219 (18%), Positives = 91/219 (41%), Gaps = 25/219 (11%)
Query: 68 SWEEQLLEQQEYLEKEMEEAKKMISGLQAL-----LLNGSLPEDEQ---ERPLALCEPGV 119
++ +Q+ E + LE+E++ + LQ+ LL E+++ E AL +
Sbjct: 1313 AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372
Query: 120 NPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQ 179
+ ++ Q EE ++ KK+L + Q A +A+ + + + +L+
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHV---EAVNAKCASLEKTKQRLQN 1429
Query: 180 ELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAK---------- 229
E+ +D + + L +K +++L E+K++ + L+ Q +
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFK 1489
Query: 230 ----LEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKR 264
EE+L +L + +L++E+ +A KR
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1528
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 50.4 bits (119), Expect = 3e-06
Identities = 33/122 (27%), Positives = 64/122 (52%), Gaps = 3/122 (2%)
Query: 129 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK 188
Q LD ++ +DLK++L ++ A LQ + L+ L Q + S +QELL A+
Sbjct: 1660 QIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1719
Query: 189 DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLE 248
LH QN L ++ + +L + + G+ + +LQ+ + E+A + ++D + +L+
Sbjct: 1720 QLLHTQNTSL---INTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK 1776
Query: 249 RE 250
+E
Sbjct: 1777 KE 1778
Score = 41.2 bits (95), Expect = 0.002
Identities = 35/166 (21%), Positives = 81/166 (48%), Gaps = 15/166 (9%)
Query: 124 QLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL-- 181
+L I++ ++S+++ + LK+E +QE +L +R+ + + Q++QE
Sbjct: 1486 ELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCE 1545
Query: 182 LRANMDKDE--LHNQNVDLQRKLDERNRLLGEYKKELGQKD-----------RLLQQHQA 228
L+A +++ E L ++ + R E N++ E +++ +KD R+++ Q+
Sbjct: 1546 LQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 229 KLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNS 274
L+ +R +D + +E +L ++ L H + A+ NY +
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRN 1651
Score = 40.8 bits (94), Expect = 0.003
Identities = 41/197 (20%), Positives = 89/197 (45%), Gaps = 27/197 (13%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
E+ L+Q E L++E + ++ IS L + G E E+ E++ +Q+
Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKK------QVEQEKCELQA 1548
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQ------ELLRA 184
L+++ + + ++L+ + E L +K + +++ ++D + QLK+ E +++
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLE---LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQS 1605
Query: 185 NMDKD-ELHNQNVDLQRK-----------LDERNRLLGEYKKELGQKDRLLQQHQAKLEE 232
+D + N + L++K L+ NR+ E + +L+ Q L++
Sbjct: 1606 TLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDD 1665
Query: 233 ALRKLSDVSYHQVDLER 249
ALR D+ +ER
Sbjct: 1666 ALRSQEDLKEQLAMVER 1682
Score = 37.4 bits (85), Expect = 0.030
Identities = 64/325 (19%), Positives = 132/325 (40%), Gaps = 46/325 (14%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
E++ E + K +E K + Q L + ED+ L + + E+Q+
Sbjct: 986 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN---TLTKAKIKLEQQV----D 1038
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDE 190
L+ S+E+ + L+ +L + K R L+G Q+ + + QL ++L + +
Sbjct: 1039 DLEGSLEQEKKLRMDLERAK---RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISN 1095
Query: 191 LHNQ-------NVDLQRKLDERNRLLGEYKKEL---------GQKDRL-LQQHQAKLEEA 233
L ++ + LQ+K+ E + E ++E+ +K R L + ++ E
Sbjct: 1096 LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1155
Query: 234 LRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATS 293
L + + Q+++ ++ E + M+R+ +EAT Q K A S
Sbjct: 1156 LEEAGGATSAQIEMNKKREAE----FQKMRRDLEEAT------LQHEATAATLRKKHADS 1205
Query: 294 VSNRG--TSDLQLVRDALRSLRNSFSGH-DPQHHTIDSLEQGISSLMERLHVMETQ---- 346
V+ G +LQ V+ L ++ D ++++ + +L + +E Q
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265
Query: 347 --KKQERKVRVKSPRTQVGSEYRES 369
K++E++ + Q G ES
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTES 1290
Score = 35.0 bits (79), Expect = 0.15
Identities = 38/179 (21%), Positives = 82/179 (45%), Gaps = 7/179 (3%)
Query: 65 LETSWEEQLLEQQEYLEKEM---EEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP 121
LET + E ++ L++ E+AKK I+ A ++ L + EQ+ L N
Sbjct: 1736 LETDISQMQGEMEDILQEARNAEEKAKKAIT--DAAMMAEELKK-EQDTSAHLERMKKNM 1792
Query: 122 EEQLIIIQSRLDQSME-ENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
E+ + +Q RLD++ + + KK++ K + R L+G ++ Q+R + + + ++
Sbjct: 1793 EQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERR 1852
Query: 181 LLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSD 239
+ +E + LQ +D+ + YK++ + + + AK + +L +
Sbjct: 1853 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEE 1911
Score = 33.1 bits (74), Expect = 0.56
Identities = 54/263 (20%), Positives = 105/263 (39%), Gaps = 40/263 (15%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
++L + E LE+E+E + S +A L + +E L E G Q+ + +
Sbjct: 1115 KELQARIEELEEEIEAERA--SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1172
Query: 131 RLDQSMEENQDLKKELLKCKQEAR------------------NLQGIKDALQQRLTQQDT 172
R + + +DL++ L+ + A NLQ +K L++ ++
Sbjct: 1173 REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1232
Query: 173 SVLQLKQEL-----LRANMDK--DELHNQNVDLQRKLDERNRLL-------GEYKKELGQ 218
+ L + + N++K L +Q +L+ K +E+ RL+ G + E G+
Sbjct: 1233 EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGE 1292
Query: 219 KDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHK---DVLLAHCM---KREADEATNY 272
R L + +A + + R + +L+R+LE + LAH + + + D
Sbjct: 1293 FSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQ 1352
Query: 273 NSHNSQSNGFLLPTAGKGATSVS 295
+S L K T V+
Sbjct: 1353 YEEEQESKAELQRALSKANTEVA 1375
Score = 32.3 bits (72), Expect = 0.96
Identities = 80/342 (23%), Positives = 139/342 (40%), Gaps = 40/342 (11%)
Query: 65 LETSWEEQLLEQQEY--LEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPE 122
LET E QQE L +++ E K I L+ + + E + L E + E
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHE 1560
Query: 123 EQLII-IQSRLDQSMEE-NQDLKKELLKCKQEARNLQGIKDALQQRL-----TQQDTSVL 175
E I+ IQ L+Q E ++ + ++ + Q RN I +++Q L ++ D L
Sbjct: 1561 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 176 QLKQE---------LLRAN-MDKDELHNQN------VDLQRKLDERNRLLGEYKKELGQK 219
+ K E L AN M + L N D Q LD+ R + K++L
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680
Query: 220 DRLLQQHQAKLEEALRKLSDVSYHQVDLEREL--EHKDVLLAHCMKRE-ADEATNYNSHN 276
+R QA++EE L + E+EL + V L H + +
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 277 SQSNGFL--LPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGIS 334
SQ G + + + A + + +D ++ + L+ +++ S H ++EQ +
Sbjct: 1741 SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAH--LERMKKNMEQTVK 1797
Query: 335 SLMERLH-----VMETQKKQERKV--RVKSPRTQVGSEYRES 369
L RL ++ KKQ +K+ RV+ +V SE + +
Sbjct: 1798 DLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1839
Score = 29.3 bits (64), Expect = 8.1
Identities = 41/219 (18%), Positives = 91/219 (41%), Gaps = 25/219 (11%)
Query: 68 SWEEQLLEQQEYLEKEMEEAKKMISGLQAL-----LLNGSLPEDEQ---ERPLALCEPGV 119
++ +Q+ E + LE+E++ + LQ+ LL E+++ E AL +
Sbjct: 1313 AFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANT 1372
Query: 120 NPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQ 179
+ ++ Q EE ++ KK+L + Q A +A+ + + + +L+
Sbjct: 1373 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHV---EAVNAKCASLEKTKQRLQN 1429
Query: 180 ELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAK---------- 229
E+ +D + + L +K +++L E+K++ + L+ Q +
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFK 1489
Query: 230 ----LEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKR 264
EE+L +L + +L++E+ +A KR
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1528
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 50.4 bits (119), Expect = 3e-06
Identities = 51/211 (24%), Positives = 92/211 (43%), Gaps = 27/211 (12%)
Query: 66 ETSWEEQLLEQQEY-LEKEMEEAKKMISGLQALLLNGSLPEDEQE-------------RP 111
E W++QLLE+ + +E+ E++ + S ++ L ED QE R
Sbjct: 1753 EIEWQKQLLERDKREIERMTAESRALQSCVECL---SKEKEDLQEKCDIWEKKLAQTKRV 1809
Query: 112 LALCEPGVNPEEQLII--------IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDAL 163
LA E E+ + +Q LDQ + L ++ +Q+ + + ++L
Sbjct: 1810 LAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSL 1869
Query: 164 QQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLL 223
Q+ L + KQ+LL +D L ++ LQ+ + E + +KE K + L
Sbjct: 1870 QEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQL 1929
Query: 224 QQHQAKLEEALRKL--SDVSYHQVDLERELE 252
Q Q ++EE KL ++ + ++ ERE E
Sbjct: 1930 QVLQNEIEENKLKLVQQEMMFQRLQKERESE 1960
Score = 46.2 bits (108), Expect = 6e-05
Identities = 52/200 (26%), Positives = 101/200 (50%), Gaps = 30/200 (15%)
Query: 65 LETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNG-----SLPEDEQ-----ERPLAL 114
LETS + L EQQ LEKE+ + K + + + +L +L E+E+ E+ L+
Sbjct: 1964 LETS-KVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQ 2022
Query: 115 CEPGVNPEEQ--------LIIIQSRLDQSMEENQDLKKELLKCKQEA-RNLQGIKDALQQ 165
+ ++ EQ L+ +Q D + L+ + L +++A + + +K+AL+
Sbjct: 2023 TKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKI 2082
Query: 166 RLTQQDTSVLQLKQE--LLRANMDKDEL-----HNQNVDLQRKLDERNRLLGEYKKEL-G 217
+ +Q + ++L+ KQE ++ M EL H + L ++L++ E KK++
Sbjct: 2083 QRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMAN 2142
Query: 218 QKDRLLQQHQAKLEEALRKL 237
QKD L++ Q ++ +A+R L
Sbjct: 2143 QKD--LERRQMEISDAMRTL 2160
Score = 45.1 bits (105), Expect = 1e-04
Identities = 39/192 (20%), Positives = 87/192 (45%), Gaps = 8/192 (4%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNG-SLPEDEQERPLALCEPGVNPEEQLIIIQ 129
E ++++ E +EK + + + + LL S +E+ E + + L+ +
Sbjct: 1415 EDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTE 1474
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD-- 187
S ++ Q+ L+K Q+ R+LQ L+Q +Q+ + ++ + + + D
Sbjct: 1475 SDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQ 1534
Query: 188 -----KDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSY 242
K++L + LQ+ ++ R + + L + + LLQ +A+LE+ +++
Sbjct: 1535 CLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQ 1594
Query: 243 HQVDLERELEHK 254
L+R+L HK
Sbjct: 1595 EMAVLDRQLGHK 1606
Score = 42.7 bits (99), Expect = 7e-04
Identities = 52/210 (24%), Positives = 92/210 (43%), Gaps = 14/210 (6%)
Query: 72 QLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSR 131
Q+ E++ L +E +K LQ +L S + E + L + + N E Q + +Q
Sbjct: 1662 QISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLE-NHELQGLKLQH- 1719
Query: 132 LDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDEL 191
DQ + E + + +L+ K E NLQ I + + Q + + K+E+ R + L
Sbjct: 1720 -DQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRAL 1778
Query: 192 HN-------QNVDLQRKLDERNRLLGEYKKELG---QKDRLLQQHQAKLEEALRKLSDVS 241
+ + DLQ K D + L + K+ L + ++ Q + KLE +RKL
Sbjct: 1779 QSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQ-E 1837
Query: 242 YHQVDLERELEHKDVLLAHCMKREADEATN 271
Q++ ++ H D+ +E EA N
Sbjct: 1838 LDQLNRDKLSLHNDISAMQQQLQEKREAVN 1867
Score = 42.4 bits (98), Expect = 0.001
Identities = 36/157 (22%), Positives = 77/157 (49%), Gaps = 9/157 (5%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEA-----RNLQGIKDALQQRLTQQDTSVLQ 176
E +L I SR+ + EE +DL+++L + + A ++L+G+ LQ+ L Q
Sbjct: 575 ESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQ 634
Query: 177 LKQELLRANMDKDELHNQNVDLQRKLDERNRLLGE---YKKELGQKDRLLQQHQAKLEEA 233
+ E + +K+ L + +++++ D+ + + +KEL + + LQ+
Sbjct: 635 AQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASL 694
Query: 234 LRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEAT 270
+ D+S ++ +LE L +D A+ +K E ++ T
Sbjct: 695 QQTQGDLSAYEAELEARLNLRDA-EANQLKEELEKVT 730
Score = 40.0 bits (92), Expect = 0.005
Identities = 46/267 (17%), Positives = 113/267 (42%), Gaps = 38/267 (14%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGI----------KDALQQRLTQQD 171
E+++ Q+RL + +E + ++++L+ +E + L+ KD L ++L+ +
Sbjct: 443 EKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRL 502
Query: 172 TSVLQLKQELLRANMDKDELHNQNVDLQRK----------LDERNRLLGEYKKELGQKDR 221
V +L+QE L + ++ + Q++ LD ++ K + K++
Sbjct: 503 QLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQ 562
Query: 222 LL-------QQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNS 274
L QQ +++L+E L +++ + DLE +L + +K++ + +
Sbjct: 563 QLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQ 622
Query: 275 HNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGIS 334
L T AT N + + +RD +L + + + ++ +
Sbjct: 623 E-------YLGTIKGQATQAQN----ECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAE 671
Query: 335 SLMERLHVMETQKKQERKVRVKSPRTQ 361
++ + L +E+ +++ +V +TQ
Sbjct: 672 NMRKELAELESALQEQHEVNASLQQTQ 698
Score = 35.4 bits (80), Expect = 0.11
Identities = 44/163 (26%), Positives = 75/163 (46%), Gaps = 11/163 (6%)
Query: 75 EQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQ 134
+ +E + E A ++ Q L SL D ++ L + + EE L I +
Sbjct: 1476 DAEELERRAQETAVNLVKADQQLR---SLQADAKD----LEQHKIKQEEILKEINKIVAA 1528
Query: 135 SMEENQDLKKELLKCKQEARNLQGIKDA-LQQRLTQQDTSVLQLKQELLRANM-DKDELH 192
+ Q L K+ K +E + LQ KD + +R VL+ + LL+A + ++L
Sbjct: 1529 KDSDFQCLSKKKEKLTEELQKLQ--KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLK 1586
Query: 193 NQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALR 235
+Q Q+++ +R LG K+EL + Q +A L+EALR
Sbjct: 1587 SQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALR 1629
Score = 34.7 bits (78), Expect = 0.19
Identities = 37/176 (21%), Positives = 80/176 (45%), Gaps = 18/176 (10%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISG-LQALLLNGSLPEDEQERPLALCEPGVNPEEQLIII 128
+E+L E+ + L+K++E A++ LQ L + L + ++ L + ++++ ++
Sbjct: 1540 KEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVL 1599
Query: 129 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK 188
+L EE L+ +++ K + LQ+ L +T V + +
Sbjct: 1600 DRQLGHKKEELHLLQGSMVQAKAD----------LQEALRLGETEVTEKCNHIREVKSLL 1649
Query: 189 DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQ-------QHQAKLEEALRKL 237
+EL Q +L ++ ER L K+E+ +++ LQ +H+ +L+ L L
Sbjct: 1650 EELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDML 1705
Score = 33.1 bits (74), Expect = 0.56
Identities = 33/167 (19%), Positives = 72/167 (43%), Gaps = 4/167 (2%)
Query: 72 QLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQ-LIIIQS 130
+L ++ + L ++ IS +Q L + + LA + +N +Q L+
Sbjct: 1833 KLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTK 1892
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDE 190
D + E L+K++ + + Q ++ QQ+L + + K +L++ M
Sbjct: 1893 HQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQR 1952
Query: 191 LHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL 237
L + + KL+ L E + +L ++ L ++KL++ L K+
Sbjct: 1953 LQKERESEESKLETSKVTLKEQQHQL---EKELTDQKSKLDQVLSKV 1996
Score = 32.0 bits (71), Expect = 1.2
Identities = 50/228 (21%), Positives = 98/228 (42%), Gaps = 34/228 (14%)
Query: 135 SMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQ 194
S+EE + L+++L K E L+ + + + QD LK+E +
Sbjct: 268 SLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAM------------ 315
Query: 195 NVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL----SDVSYHQVDLERE 250
LQ++ E E K +L K+ LL+Q +L A +K +++++++D + E
Sbjct: 316 ---LQKQSCE------ELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE 366
Query: 251 -LEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPT-AGKGATSVSNRGTSDLQLVRDA 308
L + A + + DE+ + N F + A +V + + +R+
Sbjct: 367 PLNYYPSEYAE-IDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRND 425
Query: 309 LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVM--ETQKKQERKVR 354
+LR GH P ++ E+ IS+ RL + E +K +++ +R
Sbjct: 426 HMNLR----GHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILR 469
Score = 31.2 bits (69), Expect = 2.1
Identities = 19/86 (22%), Positives = 43/86 (50%), Gaps = 3/86 (3%)
Query: 123 EQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELL 182
E++ ++ L++ M E ++LK + + +E +N + +L++ Q S +LK +L
Sbjct: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDL- 328
Query: 183 RANMDKDELHNQNVDLQRKLDERNRL 208
N + L + ++L R ++ L
Sbjct: 329 --NTKNELLKQKTIELTRACQKQYEL 352
Score = 30.8 bits (68), Expect = 2.8
Identities = 31/140 (22%), Positives = 59/140 (42%), Gaps = 4/140 (2%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
E+++ + +D ++E + L+ E+ + + + Q KD + + T L++++ L
Sbjct: 1353 EKEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTE-LEIEKSL 1411
Query: 182 LRANMDKDELHNQNVDLQRK---LDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLS 238
DE+ L ++ L E +RLL E + EL + K +A R L
Sbjct: 1412 KHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLL 1471
Query: 239 DVSYHQVDLERELEHKDVLL 258
+LER + V L
Sbjct: 1472 QTESDAEELERRAQETAVNL 1491
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 49.3 bits (116), Expect = 8e-06
Identities = 64/241 (26%), Positives = 108/241 (44%), Gaps = 31/241 (12%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
++ L +++S L + + QDL+++L C QEA NL LQQ+ Q + L+Q L
Sbjct: 385 DKALTLVRSVLTRRRQAVQDLRQQLAGC-QEAVNL------LQQQHDQWEEEGKALRQRL 437
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDR--LLQQHQAKLEEALRKLSD 239
+ ++D L Q VDLQ ++D ++ ++EL QK R L QQ + +EA R
Sbjct: 438 QKLTGERDTLAGQTVDLQGEVDSLSK-----ERELLQKAREELRQQLEVLEQEAWR---- 488
Query: 240 VSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGT 299
+V++E +L+ A K E E + + +L G + +
Sbjct: 489 --LRRVNVELQLQGDS---AQGQKEEQQEELHLAVRERERLQEML----MGLEAKQSESL 539
Query: 300 SDLQLVRDALRS--LRNSFSGHDPQHHT--IDSLEQGISSLMERLHVMETQKKQERKVRV 355
S+L +R+AL S L + T + EQ I+ L + ++T+ R V
Sbjct: 540 SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAV 599
Query: 356 K 356
K
Sbjct: 600 K 600
Score = 47.0 bits (110), Expect = 4e-05
Identities = 72/351 (20%), Positives = 142/351 (40%), Gaps = 56/351 (15%)
Query: 66 ETSWEEQ-LLEQQEYLEKEMEEAKKMISGLQALL--LNGSLPEDEQERPLALCEPGVNPE 122
E SW +Q L + E LE+E E + + Q + + E+ + ALC+ + E
Sbjct: 865 ERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETE 924
Query: 123 EQLIIIQSRLDQSMEENQDLKKELLKCKQEAR---------------NLQGIKDALQQRL 167
++ + + L Q+ +E D ++L + +Q+ + LQ + L++
Sbjct: 925 KERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
Query: 168 TQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQ 227
Q + L++E DK +L Q DL+ +L ++ RL++Q
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD-----------DSQRLVEQ-- 1031
Query: 228 AKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHN-SQSNGFLLPT 286
+++E LR+ + + Q +LERE K L M++E + + Q L
Sbjct: 1032 -EVQEKLRETQEYNRIQKELERE---KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087
Query: 287 AGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQ 346
+ A ++ ++L+R ++ F + Q LE+ +E H+ E Q
Sbjct: 1088 DMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ-----LLEE-----LEASHITEQQ 1137
Query: 347 ----------KKQERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSS 387
K + ++R++S +Q+ + E P N +Q + S+
Sbjct: 1138 LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA 1188
Score = 41.2 bits (95), Expect = 0.002
Identities = 56/266 (21%), Positives = 118/266 (44%), Gaps = 36/266 (13%)
Query: 99 LNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQG 158
L G + E E++R + E L + + +Q ++ Q+ +EL KC+ +L
Sbjct: 1440 LRGQIQELEKQREMQKAAL-----ELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPM 1494
Query: 159 IKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRK---LDERNRLLGEYKKE 215
+Q+LT Q + +L+++ ++ L +Q ++L++K ++ + + + KK+
Sbjct: 1495 AVQEREQKLTVQREQIRELEKD---RETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQ 1551
Query: 216 LGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCM-----KREADEAT 270
L + L +LEE K+ +LE + E + V L H + + +A
Sbjct: 1552 LVTLECL----ALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ 1607
Query: 271 NYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLE 330
+ H+ +S+ +L A + R +++ R+ + L+ + H LE
Sbjct: 1608 SSQIHDLESHSTVL------ARELQER-DQEVKSQREQIEELQRQ------KEHLTQDLE 1654
Query: 331 QGISSLM---ERLHVMETQKKQERKV 353
+ LM ER+ V+E Q+ ++ K+
Sbjct: 1655 RRDQELMLQKERIQVLEDQRTRQTKI 1680
Score = 40.4 bits (93), Expect = 0.004
Identities = 59/297 (19%), Positives = 113/297 (38%), Gaps = 46/297 (15%)
Query: 15 IHSAKSESIITQSEEKADFVIIPAEGIENRTEGT--DSPLSRDWRPGSPGTYLETSWEEQ 72
+H E+ + S+ + + V++ + E R +G + L E
Sbjct: 1762 LHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA 1821
Query: 73 LLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRL 132
L ++Q+ + + E K+ LQ L + E+ L + E+ + ++ R
Sbjct: 1822 LQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRR 1881
Query: 133 DQSMEE--------NQDLKKELL----KCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
Q++EE +++ +K LL +C ++A+ + ALQ Q + + QE
Sbjct: 1882 VQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQE 1941
Query: 181 LLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKEL-GQKDRLLQQ-------------- 225
L + +Q + + + LG+ L G++ LL+Q
Sbjct: 1942 LEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
Query: 226 ---------HQAKLEEALR------KLSDVSYHQ--VDLERELEHKDVLLAHCMKRE 265
H +LEEALR + D+ Y + L++ L +D L H +RE
Sbjct: 2002 QASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQERE 2058
Score = 39.3 bits (90), Expect = 0.008
Identities = 65/304 (21%), Positives = 121/304 (39%), Gaps = 28/304 (9%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
E L Q + LEK+ E K + L L + D Q+ + E + E L +
Sbjct: 1438 ETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQ 1497
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIK----DALQQRLTQQDTSVLQLKQELLRAN- 185
+Q + ++ +EL K ++ RN+ + + Q + Q V LK++L+
Sbjct: 1498 EREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLEC 1557
Query: 186 --MDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYH 243
++ +E H++ Q+ + E + L L++ +L+ ++ D+ H
Sbjct: 1558 LALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESH 1617
Query: 244 QVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQ 303
L REL+ +D + + + +E H +Q R +L
Sbjct: 1618 STVLARELQERDQEV-KSQREQIEELQRQKEHLTQD---------------LERRDQELM 1661
Query: 304 LVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKK--QERKVRVKSP-RT 360
L ++ ++ L + + + LEQ SL ER + TQ++ QER K P +
Sbjct: 1662 LQKERIQVLEDQRTRQTKILE--EDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719
Query: 361 QVGS 364
Q GS
Sbjct: 1720 QRGS 1723
Score = 39.3 bits (90), Expect = 0.008
Identities = 44/200 (22%), Positives = 90/200 (45%), Gaps = 25/200 (12%)
Query: 81 EKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP--------EEQLIIIQSRL 132
EKE+E ++ I LQ L +D+ E+ L V E++++++Q +L
Sbjct: 1735 EKEVECQQEHIHELQEL-------KDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQL 1787
Query: 133 DQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELH 192
++ E+ + LK++ +LQ D Q+ L Q+D + L+QE +A ++ +
Sbjct: 1788 QEAREQGE-LKEQ---------SLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVK 1837
Query: 193 NQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELE 252
+ LQ L++ + L E EL ++ + +L R++ + DL E
Sbjct: 1838 EKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESR 1897
Query: 253 HKDVLLAHCMKREADEATNY 272
++ L ++ A++A +
Sbjct: 1898 EQEKALLALQQQCAEQAQEH 1917
Score = 37.0 bits (84), Expect = 0.039
Identities = 62/284 (21%), Positives = 112/284 (39%), Gaps = 50/284 (17%)
Query: 122 EEQLIIIQSRLDQSMEEN----QDLKKEL----------------LKCKQEA-RNLQGIK 160
E QL+ ++ + DQ +E QDLKK+L ++C+Q+ + L+G +
Sbjct: 1525 EHQLLELEKK-DQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR 1583
Query: 161 DALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKEL---- 216
+ + LT + + QEL + +L + + L R+L ER++ + ++++
Sbjct: 1584 ETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQ 1643
Query: 217 GQKDRLLQ------QHQAKLEEALRKLSDVSYHQVD-LERELEHKDVLLAHCMKREADEA 269
QK+ L Q Q +E ++ L D Q LE +LE + L RE
Sbjct: 1644 RQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL-----RERGRE 1698
Query: 270 TNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSL 329
Q GKG + ++L+ LR H + L
Sbjct: 1699 LTTQRQLMQERA----EEGKGPSKAQRGSLEHMKLI---LRDKEKEVECQQEHIHELQEL 1751
Query: 330 EQGISSLMERLH--VMETQ---KKQERKVRVKSPRTQVGSEYRE 368
+ + ++ LH V ET ++E+++ V + Q E E
Sbjct: 1752 KDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE 1795
Score = 36.2 bits (82), Expect = 0.066
Identities = 64/297 (21%), Positives = 122/297 (41%), Gaps = 40/297 (13%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
E L E+ +LE ++++A++ + LQA L + + E+++E IQ
Sbjct: 655 EALWEKNTHLEAQLQKAEEAGAELQADLRD--IQEEKEE------------------IQK 694
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDE 190
+L +S + + +L + QEA+ ++ + R Q+ ++++ K L E
Sbjct: 695 KLSESRHQQEAATTQLEQLHQEAKR----QEEVLARAVQEKEALVREKAAL--------E 742
Query: 191 LHNQNVDLQRKLDERNRLLG-EYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLER 249
+ Q V+ R+ D +L G KEL + Q Q + E + +V V +
Sbjct: 743 VRLQAVERDRQ-DLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801
Query: 250 ELEHKDVLLAHCMKREAD-EATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDA 308
E+ +V C+K E D E + + L +G T++ + + + V
Sbjct: 802 EVIQGEV---RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL 858
Query: 309 LRSLRNSFSGHDPQ-HHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGS 364
S H + ++SLE+ L RL +T+ + + R + RTQ S
Sbjct: 859 REKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQR-EEERTQAES 914
Score = 35.0 bits (79), Expect = 0.15
Identities = 20/78 (25%), Positives = 41/78 (52%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
EE+L ++ Q E QDL+++L + ++E +G +++L+ L + ++ L+ L
Sbjct: 1270 EERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRL 1329
Query: 182 LRANMDKDELHNQNVDLQ 199
RA + + E + LQ
Sbjct: 1330 RRAELQRMEAQGERELLQ 1347
Score = 33.1 bits (74), Expect = 0.56
Identities = 27/109 (24%), Positives = 54/109 (49%), Gaps = 11/109 (10%)
Query: 146 LLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDER 205
L K Q+ Q +D L+ + V +L++ L +K ++H + DLQR+L +
Sbjct: 1245 LHKLHQDLWKTQQTRDVLRDQ-------VQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297
Query: 206 NRLLGEYK-KELGQKDRLLQQHQ--AKLEEALRKLSDVSYHQVDLEREL 251
+++ K+ + L++ H+ A L+ LR+ +++ + EREL
Sbjct: 1298 QEEKSKWEGKQNSLESELMELHETMASLQSRLRR-AELQRMEAQGEREL 1345
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 49.3 bits (116), Expect = 8e-06
Identities = 53/215 (24%), Positives = 102/215 (47%), Gaps = 29/215 (13%)
Query: 66 ETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQE---RPLALCEPGVNPE 122
+T +E Q+ E+ + +++ +E + LQ L ++E+E R + P
Sbjct: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
Query: 123 EQLIIIQSRLDQSMEENQDLKKELLKCKQEAR----NLQGIKDALQQRLTQQDTSVLQLK 178
EQ Q ++E + L KE L+ + +A +LQ AL+ + +Q + ++L+
Sbjct: 1991 EQ---------QLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELE 2041
Query: 179 QELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALR--- 235
QE N + +L QN L+++L++ + L E + + + QQ KLE+ L+
Sbjct: 2042 QE---KNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
Query: 236 KLSDVSYHQVDLERELEHKDVLLAHCMKREADEAT 270
+ +S HQ RE+E LA+ +K + D+ +
Sbjct: 2099 RFQPISEHQT---REVEQ----LANHLKEKTDKCS 2126
Score = 42.7 bits (99), Expect = 7e-04
Identities = 51/230 (22%), Positives = 95/230 (41%), Gaps = 13/230 (5%)
Query: 65 LETSWEEQLLEQQEYLE-KEMEEAKKMISGLQAL--LLNGSL----PEDEQERPLA-LCE 116
LE +EQ +E Q +E + + + ++S +QAL +NG E E E+P L E
Sbjct: 3064 LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLE 3123
Query: 117 PGVNPEEQLII-----IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQD 171
+ ++ ++ + S D++ E + L E + + L K L+ L Q
Sbjct: 3124 YNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQH 3183
Query: 172 TSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLE 231
+ +L+ L DE+H N L + + L +KE + R ++ + +LE
Sbjct: 3184 KHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELE 3243
Query: 232 EALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNG 281
+ L + L LE + LL ++ + Y++ S+ G
Sbjct: 3244 DLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQG 3293
Score = 40.0 bits (92), Expect = 0.005
Identities = 48/226 (21%), Positives = 94/226 (41%), Gaps = 11/226 (4%)
Query: 124 QLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLR 183
Q+ +Q ++ + E QD K E K+E + + I + L ++ +++ L+LK +L
Sbjct: 297 QISFLQEKI-KVYEMEQDKKVENSN-KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTT 354
Query: 184 ANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYH 243
A+ EL Q V +++ L K++ Q ++Q +EE ++ S
Sbjct: 355 ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF 414
Query: 244 QVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQ 303
+ D+ + +E + ++ E DE Y Q L+ + R +++
Sbjct: 415 ETDIVQRMEQETQRKLEQLRAELDEM--YGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
Query: 304 LVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQ 349
+ALRS N D I + I+ L +L +QK++
Sbjct: 473 ---NALRSYSNITVNED----QIKLMNVAINELNIKLQDTNSQKEK 511
Score = 39.7 bits (91), Expect = 0.006
Identities = 76/348 (21%), Positives = 131/348 (37%), Gaps = 60/348 (17%)
Query: 37 PAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEY--LEKEMEEAKKMIS-- 92
P + G D S SP T+LE E +Q E L +E+EE +
Sbjct: 130 PTNLLREEEFGVDDSYSEQGAQDSP-THLEMMESELAGKQHEIEELNRELEEMRVTYGTE 188
Query: 93 GLQALLLNGSLPEDEQERPLALCEPGVNPEEQLII-IQSRLDQSMEENQDLKKELLKCKQ 151
GLQ L QE E + + +I + + L Q+ E + +E L+ +
Sbjct: 189 GLQQL----------QE-----FEAAIKQRDGIITQLTANLQQARREKDETMREFLELTE 233
Query: 152 EARNLQGIKDALQQRLTQQDTS-------VLQLKQELLRANMDKDELHNQNVDLQRK--- 201
+++ LQ LQ T ++++ +LQ KQ++L +E + D Q+K
Sbjct: 234 QSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKED 293
Query: 202 ----------------LDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRK---LSDVSY 242
+++ ++ K+E+ +K+ ++++ K+ E +K L D
Sbjct: 294 FTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLT 353
Query: 243 HQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDL 302
L EL+ + V +K E TN QS+ + G + R D
Sbjct: 354 TADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGT-VEELQKRNHKDS 412
Query: 303 QLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQE 350
Q D ++ + + T LEQ + L E Q KQE
Sbjct: 413 QFETDIVQRM---------EQETQRKLEQLRAELDEMYGQQIVQMKQE 451
Score = 39.7 bits (91), Expect = 0.006
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 35/243 (14%)
Query: 63 TYLETSWEEQLLEQQEYLEKE----MEEAKKMISGLQALLLNGSLPEDEQERPLALCEPG 118
T L S EE+L + +E LE E +E+ K + ++G E Q+ E
Sbjct: 627 TQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFE-- 684
Query: 119 VNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLT---------- 168
++ LI Q++L + + +DL++ L+ K E LQ + LQ+ +
Sbjct: 685 ---KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ--INELQKEIEILRQEEKEKG 739
Query: 169 --QQDTSVLQLKQELLRANMDKDELHNQNVDLQRK---LDERNRLLGEYKKELGQKDRL- 222
+Q+ LQLK ELL M + E DLQ K L+ N +L + KK L ++
Sbjct: 740 TLEQEVQELQLKTELLEKQMKEKE-----NDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
Query: 223 ---LQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQS 279
Q+ + ++++ S S + ++E +E + L C++ + N+ +
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
Query: 280 NGF 282
F
Sbjct: 855 KNF 857
Score = 38.5 bits (88), Expect = 0.013
Identities = 66/289 (22%), Positives = 126/289 (43%), Gaps = 65/289 (22%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALL-LNGSLPEDEQ---ERPLALCEPGVNPEEQLI 126
++L + E LEK+M+E + + A L S+ +DE+ E L + P V+ EE+LI
Sbjct: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTP-VSQEERLI 804
Query: 127 IIQSRLDQS------------MEENQDLKKELLKCKQEARNLQGIKDALQ-------QRL 167
+ S +S +EEN+DLK++ ++ +E + + Q L
Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
Query: 168 TQQDTSVLQLKQELLRANMDKDELH--------NQNVDLQR-----------KLDERNRL 208
++ +L++K + L + +K EL N+ + LQR DE
Sbjct: 865 QEEYACLLKVKDD-LEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTF 923
Query: 209 LGE----------------YKKELGQKDRL-LQQHQAKLEEALR-KLSDVSYHQVDLERE 250
+ E K E+ ++++L L Q + L E L+ K ++S+ +++
Sbjct: 924 VAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSL 983
Query: 251 LEHKDVLLAHCMKREADEATNYN-SHNSQSNGFLLPTAGKGATSVSNRG 298
+ K+ + C RE + N+N + N QS + + G ++++RG
Sbjct: 984 KQEKEQVSLRC--RELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRG 1030
Score = 37.7 bits (86), Expect = 0.023
Identities = 24/103 (23%), Positives = 53/103 (51%)
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKD 189
S+L+ + +L +E + KQEA ++ L++RL ++ + QL EL +A D
Sbjct: 1866 SQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVID 1925
Query: 190 ELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEE 232
++ +R++ E+ ++ ++EL LQ+ +A+ ++
Sbjct: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
Score = 37.7 bits (86), Expect = 0.023
Identities = 48/198 (24%), Positives = 89/198 (44%), Gaps = 25/198 (12%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQER--PLALCEPGVNPEEQLIII 128
E + E L ++E S L LL L D QER + E V EQ +++
Sbjct: 2105 EHQTREVEQLANHLKEKTDKCSEL--LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162
Query: 129 QSRLDQSMEENQDLKKELLKCKQEAR-NLQGIKDALQQR---LTQQDTSVLQLKQELLRA 184
+ Q +E+ + K + LQ +DA+ ++ +T + + Q ++EL
Sbjct: 2163 SADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENK 2222
Query: 185 NMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVS--- 241
N + +LH Q +++Q+K + RL +EL Q+++L + KL A+++ +S
Sbjct: 2223 NEEVQQLHMQ-LEIQKK-ESTTRL-----QELEQENKLFKDDMEKLGLAIKESDAMSTQD 2275
Query: 242 -------YHQVDLERELE 252
+ Q+ E+E+E
Sbjct: 2276 QHVLFGKFAQIIQEKEVE 2293
Score = 37.0 bits (84), Expect = 0.039
Identities = 67/285 (23%), Positives = 119/285 (41%), Gaps = 51/285 (17%)
Query: 74 LEQQEYLEKEMEEAKKMISGL-QALLLNGSLPEDE---QERPLALCEPGVNP-EEQLIII 128
LE Q LE E ++M S L + L+ L + Q RP E + ++QL
Sbjct: 3296 LELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3355
Query: 129 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK 188
SR+ + + E + K + L+ +Q+ KD R T LQ +QE K
Sbjct: 3356 HSRIVELLNETEKYKLDSLQTRQQME-----KDRQVHRKT------LQTEQEANTEGQKK 3404
Query: 189 -DELHNQNVDLQRKLDERNRLLGEYKKEL-GQKDRLLQQHQAKLEEALRKLSDVSYHQVD 246
EL ++ DLQR+L+E+ + + YK +L GQ+ + + Q + + +
Sbjct: 3405 MHELQSKVEDLQRQLEEKRQQV--YKLDLEGQRLQGIMQ---------------EFQKQE 3447
Query: 247 LERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVR 306
LERE + + + + +E T ++ + ++ ++L +G T SN
Sbjct: 3448 LEREEKRES---RRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESN---------- 3494
Query: 307 DALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQER 351
L G +H ++ + Q + + +L V+ QK ER
Sbjct: 3495 --YAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVL-PQKASER 3536
Score = 35.4 bits (80), Expect = 0.11
Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 23/198 (11%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
EE+ E+ E L+ +E K+ L LL EQ++ L L E E Q ++
Sbjct: 3235 EERDKEELEDLKFSLESQKQRNLQLNLLL--------EQQKQL-LNESQQKIESQRMLYD 3285
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDA---LQQRLTQQD---TSVLQLKQELLR 183
++L + N +L+ L K R + D L +L D S L E L
Sbjct: 3286 AQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLL 3345
Query: 184 ANMDK--DELHNQNVDLQRKLDERNRLLGEYKKELGQKDR-----LLQQHQAKLEEALRK 236
+ K +E H++ V+L + E+ +L ++ +KDR LQ Q E +K
Sbjct: 3346 KELQKQLEEKHSRIVELLNET-EKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKK 3404
Query: 237 LSDVSYHQVDLERELEHK 254
+ ++ DL+R+LE K
Sbjct: 3405 MHELQSKVEDLQRQLEEK 3422
Score = 34.7 bits (78), Expect = 0.19
Identities = 34/161 (21%), Positives = 73/161 (45%), Gaps = 7/161 (4%)
Query: 57 RPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQ-ERPLALC 115
RP P L ++QL E+ + + + E +K L +L + +D Q R
Sbjct: 3336 RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY--KLDSLQTRQQMEKDRQVHRKTLQT 3393
Query: 116 EPGVNPEEQLII--IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTS 173
E N E Q + +QS+++ + ++ ++++ K E + LQGI Q++ +++
Sbjct: 3394 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEK 3453
Query: 174 VLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKK 214
+ + +L N+++ + D R + ++ GE K+
Sbjct: 3454 --RESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKE 3492
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 49.3 bits (116), Expect = 8e-06
Identities = 53/215 (24%), Positives = 102/215 (47%), Gaps = 29/215 (13%)
Query: 66 ETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQE---RPLALCEPGVNPE 122
+T +E Q+ E+ + +++ +E + LQ L ++E+E R + P
Sbjct: 1931 KTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV 1990
Query: 123 EQLIIIQSRLDQSMEENQDLKKELLKCKQEAR----NLQGIKDALQQRLTQQDTSVLQLK 178
EQ Q ++E + L KE L+ + +A +LQ AL+ + +Q + ++L+
Sbjct: 1991 EQ---------QLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELE 2041
Query: 179 QELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALR--- 235
QE N + +L QN L+++L++ + L E + + + QQ KLE+ L+
Sbjct: 2042 QE---KNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP 2098
Query: 236 KLSDVSYHQVDLERELEHKDVLLAHCMKREADEAT 270
+ +S HQ RE+E LA+ +K + D+ +
Sbjct: 2099 RFQPISEHQT---REVEQ----LANHLKEKTDKCS 2126
Score = 42.7 bits (99), Expect = 7e-04
Identities = 51/230 (22%), Positives = 95/230 (41%), Gaps = 13/230 (5%)
Query: 65 LETSWEEQLLEQQEYLE-KEMEEAKKMISGLQAL--LLNGSL----PEDEQERPLA-LCE 116
LE +EQ +E Q +E + + + ++S +QAL +NG E E E+P L E
Sbjct: 3056 LEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLE 3115
Query: 117 PGVNPEEQLII-----IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQD 171
+ ++ ++ + S D++ E + L E + + L K L+ L Q
Sbjct: 3116 YNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQH 3175
Query: 172 TSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLE 231
+ +L+ L DE+H N L + + L +KE + R ++ + +LE
Sbjct: 3176 KHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELE 3235
Query: 232 EALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNG 281
+ L + L LE + LL ++ + Y++ S+ G
Sbjct: 3236 DLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQG 3285
Score = 40.0 bits (92), Expect = 0.005
Identities = 48/226 (21%), Positives = 94/226 (41%), Gaps = 11/226 (4%)
Query: 124 QLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLR 183
Q+ +Q ++ + E QD K E K+E + + I + L ++ +++ L+LK +L
Sbjct: 297 QISFLQEKI-KVYEMEQDKKVENSN-KEEIQEKETIIEELNTKIIEEEKKTLELKDKLTT 354
Query: 184 ANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYH 243
A+ EL Q V +++ L K++ Q ++Q +EE ++ S
Sbjct: 355 ADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQF 414
Query: 244 QVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQ 303
+ D+ + +E + ++ E DE Y Q L+ + R +++
Sbjct: 415 ETDIVQRMEQETQRKLEQLRAELDEM--YGQQIVQMKQELIRQHMAQMEEMKTRHKGEME 472
Query: 304 LVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQ 349
+ALRS N D I + I+ L +L +QK++
Sbjct: 473 ---NALRSYSNITVNED----QIKLMNVAINELNIKLQDTNSQKEK 511
Score = 39.7 bits (91), Expect = 0.006
Identities = 76/348 (21%), Positives = 131/348 (37%), Gaps = 60/348 (17%)
Query: 37 PAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEY--LEKEMEEAKKMIS-- 92
P + G D S SP T+LE E +Q E L +E+EE +
Sbjct: 130 PTNLLREEEFGVDDSYSEQGAQDSP-THLEMMESELAGKQHEIEELNRELEEMRVTYGTE 188
Query: 93 GLQALLLNGSLPEDEQERPLALCEPGVNPEEQLII-IQSRLDQSMEENQDLKKELLKCKQ 151
GLQ L QE E + + +I + + L Q+ E + +E L+ +
Sbjct: 189 GLQQL----------QE-----FEAAIKQRDGIITQLTANLQQARREKDETMREFLELTE 233
Query: 152 EARNLQGIKDALQQRLTQQDTS-------VLQLKQELLRANMDKDELHNQNVDLQRK--- 201
+++ LQ LQ T ++++ +LQ KQ++L +E + D Q+K
Sbjct: 234 QSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKED 293
Query: 202 ----------------LDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRK---LSDVSY 242
+++ ++ K+E+ +K+ ++++ K+ E +K L D
Sbjct: 294 FTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLT 353
Query: 243 HQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDL 302
L EL+ + V +K E TN QS+ + G + R D
Sbjct: 354 TADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGT-VEELQKRNHKDS 412
Query: 303 QLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQE 350
Q D ++ + + T LEQ + L E Q KQE
Sbjct: 413 QFETDIVQRM---------EQETQRKLEQLRAELDEMYGQQIVQMKQE 451
Score = 39.7 bits (91), Expect = 0.006
Identities = 58/243 (23%), Positives = 104/243 (42%), Gaps = 35/243 (14%)
Query: 63 TYLETSWEEQLLEQQEYLEKE----MEEAKKMISGLQALLLNGSLPEDEQERPLALCEPG 118
T L S EE+L + +E LE E +E+ K + ++G E Q+ E
Sbjct: 627 TQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFE-- 684
Query: 119 VNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLT---------- 168
++ LI Q++L + + +DL++ L+ K E LQ + LQ+ +
Sbjct: 685 ---KDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQ--INELQKEIEILRQEEKEKG 739
Query: 169 --QQDTSVLQLKQELLRANMDKDELHNQNVDLQRK---LDERNRLLGEYKKELGQKDRL- 222
+Q+ LQLK ELL M + E DLQ K L+ N +L + KK L ++
Sbjct: 740 TLEQEVQELQLKTELLEKQMKEKE-----NDLQEKFAQLEAENSILKDEKKTLEDMLKIH 794
Query: 223 ---LQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQS 279
Q+ + ++++ S S + ++E +E + L C++ + N+ +
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
Query: 280 NGF 282
F
Sbjct: 855 KNF 857
Score = 38.5 bits (88), Expect = 0.013
Identities = 66/289 (22%), Positives = 126/289 (43%), Gaps = 65/289 (22%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALL-LNGSLPEDEQ---ERPLALCEPGVNPEEQLI 126
++L + E LEK+M+E + + A L S+ +DE+ E L + P V+ EE+LI
Sbjct: 746 QELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTP-VSQEERLI 804
Query: 127 IIQSRLDQS------------MEENQDLKKELLKCKQEARNLQGIKDALQ-------QRL 167
+ S +S +EEN+DLK++ ++ +E + + Q L
Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
Query: 168 TQQDTSVLQLKQELLRANMDKDELH--------NQNVDLQR-----------KLDERNRL 208
++ +L++K + L + +K EL N+ + LQR DE
Sbjct: 865 QEEYACLLKVKDD-LEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTF 923
Query: 209 LGE----------------YKKELGQKDRL-LQQHQAKLEEALR-KLSDVSYHQVDLERE 250
+ E K E+ ++++L L Q + L E L+ K ++S+ +++
Sbjct: 924 VAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSL 983
Query: 251 LEHKDVLLAHCMKREADEATNYN-SHNSQSNGFLLPTAGKGATSVSNRG 298
+ K+ + C RE + N+N + N QS + + G ++++RG
Sbjct: 984 KQEKEQVSLRC--RELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRG 1030
Score = 37.7 bits (86), Expect = 0.023
Identities = 24/103 (23%), Positives = 53/103 (51%)
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKD 189
S+L+ + +L +E + KQEA ++ L++RL ++ + QL EL +A D
Sbjct: 1866 SQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVID 1925
Query: 190 ELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEE 232
++ +R++ E+ ++ ++EL LQ+ +A+ ++
Sbjct: 1926 GYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
Score = 37.4 bits (85), Expect = 0.030
Identities = 49/198 (24%), Positives = 90/198 (45%), Gaps = 33/198 (16%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQER--PLALCEPGVNPEEQLIII 128
E + E L ++E S L LL L D QER + E V EQ +++
Sbjct: 2105 EHQTREVEQLANHLKEKTDKCSEL--LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLV 2162
Query: 129 QSRLD-QSMEENQDLKKELLKCKQEARNLQGIKDALQQR---LTQQDTSVLQLKQELLRA 184
+ R ++E +L E+ LQ +DA+ ++ +T + + Q ++EL
Sbjct: 2163 EDRKHFGAVEAKPELSLEV--------QLQAERDAIDRKEKEITNLEEQLEQFREELENK 2214
Query: 185 NMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVS--- 241
N + +LH Q +++Q+K + RL +EL Q+++L + KL A+++ +S
Sbjct: 2215 NEEVQQLHMQ-LEIQKK-ESTTRL-----QELEQENKLFKDDMEKLGLAIKESDAMSTQD 2267
Query: 242 -------YHQVDLERELE 252
+ Q+ E+E+E
Sbjct: 2268 QHVLFGKFAQIIQEKEVE 2285
Score = 37.0 bits (84), Expect = 0.039
Identities = 67/285 (23%), Positives = 119/285 (41%), Gaps = 51/285 (17%)
Query: 74 LEQQEYLEKEMEEAKKMISGL-QALLLNGSLPEDE---QERPLALCEPGVNP-EEQLIII 128
LE Q LE E ++M S L + L+ L + Q RP E + ++QL
Sbjct: 3288 LELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3347
Query: 129 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK 188
SR+ + + E + K + L+ +Q+ KD R T LQ +QE K
Sbjct: 3348 HSRIVELLNETEKYKLDSLQTRQQME-----KDRQVHRKT------LQTEQEANTEGQKK 3396
Query: 189 -DELHNQNVDLQRKLDERNRLLGEYKKEL-GQKDRLLQQHQAKLEEALRKLSDVSYHQVD 246
EL ++ DLQR+L+E+ + + YK +L GQ+ + + Q + + +
Sbjct: 3397 MHELQSKVEDLQRQLEEKRQQV--YKLDLEGQRLQGIMQ---------------EFQKQE 3439
Query: 247 LERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVR 306
LERE + + + + +E T ++ + ++ ++L +G T SN
Sbjct: 3440 LEREEKRES---RRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESN---------- 3486
Query: 307 DALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQER 351
L G +H ++ + Q + + +L V+ QK ER
Sbjct: 3487 --YAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVL-PQKASER 3528
Score = 35.4 bits (80), Expect = 0.11
Identities = 52/198 (26%), Positives = 85/198 (42%), Gaps = 23/198 (11%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQ 129
EE+ E+ E L+ +E K+ L LL EQ++ L L E E Q ++
Sbjct: 3227 EERDKEELEDLKFSLESQKQRNLQLNLLL--------EQQKQL-LNESQQKIESQRMLYD 3277
Query: 130 SRLDQSMEENQDLKKELLKCKQEARNLQGIKDA---LQQRLTQQD---TSVLQLKQELLR 183
++L + N +L+ L K R + D L +L D S L E L
Sbjct: 3278 AQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLL 3337
Query: 184 ANMDK--DELHNQNVDLQRKLDERNRLLGEYKKELGQKDR-----LLQQHQAKLEEALRK 236
+ K +E H++ V+L + E+ +L ++ +KDR LQ Q E +K
Sbjct: 3338 KELQKQLEEKHSRIVELLNET-EKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKK 3396
Query: 237 LSDVSYHQVDLERELEHK 254
+ ++ DL+R+LE K
Sbjct: 3397 MHELQSKVEDLQRQLEEK 3414
Score = 34.7 bits (78), Expect = 0.19
Identities = 34/161 (21%), Positives = 73/161 (45%), Gaps = 7/161 (4%)
Query: 57 RPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQ-ERPLALC 115
RP P L ++QL E+ + + + E +K L +L + +D Q R
Sbjct: 3328 RPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY--KLDSLQTRQQMEKDRQVHRKTLQT 3385
Query: 116 EPGVNPEEQLII--IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTS 173
E N E Q + +QS+++ + ++ ++++ K E + LQGI Q++ +++
Sbjct: 3386 EQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEK 3445
Query: 174 VLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKK 214
+ + +L N+++ + D R + ++ GE K+
Sbjct: 3446 --RESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKE 3484
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 49.3 bits (116), Expect = 8e-06
Identities = 32/122 (26%), Positives = 64/122 (52%), Gaps = 3/122 (2%)
Query: 129 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK 188
Q LD ++ +DLK++L ++ A LQ + L+ L Q + S +QELL A+
Sbjct: 1658 QLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1717
Query: 189 DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLE 248
LH QN L ++ + +L + + G+ + ++Q+ + E+A + ++D + +L+
Sbjct: 1718 QLLHTQNTSL---INTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELK 1774
Query: 249 RE 250
+E
Sbjct: 1775 KE 1776
Score = 40.4 bits (93), Expect = 0.004
Identities = 43/198 (21%), Positives = 88/198 (44%), Gaps = 29/198 (14%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
E+ L+Q E L++E + ++ IS L + G E E+ ++Q+ +S
Sbjct: 1493 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI----------KKQVEQEKS 1542
Query: 131 RLDQSMEENQ-DLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQ------ELLR 183
L ++EE + L+ E K + L +K + +++ ++D + Q+K+ E ++
Sbjct: 1543 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQ 1602
Query: 184 ANMDKD-ELHNQNVDLQRK-----------LDERNRLLGEYKKELGQKDRLLQQHQAKLE 231
+ +D + N + L++K L+ NR+ E + +L+ Q L+
Sbjct: 1603 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLD 1662
Query: 232 EALRKLSDVSYHQVDLER 249
+ALR D+ +ER
Sbjct: 1663 DALRSQEDLKEQLAMVER 1680
Score = 35.8 bits (81), Expect = 0.087
Identities = 81/342 (23%), Positives = 139/342 (40%), Gaps = 40/342 (11%)
Query: 65 LETSWEEQLLEQQEY--LEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPE 122
LET E QQE L +++ E K I L+ + + E + L E + E
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHE 1558
Query: 123 EQLII-IQSRLDQSMEE-NQDLKKELLKCKQEARNLQGIKDALQQRL-----TQQDTSVL 175
E I+ IQ L+Q E ++ + ++ + Q RN I +++Q L ++ D L
Sbjct: 1559 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL 1618
Query: 176 QLKQE---------LLRAN-MDKDELHNQN------VDLQRKLDERNRLLGEYKKELGQK 219
+ K E L AN M + L N D Q LD+ R + K++L
Sbjct: 1619 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMV 1678
Query: 220 DRLLQQHQAKLEEALRKLSDVSYHQVDLEREL--EHKDVLLAHCMKRE-ADEATNYNSHN 276
+R QA++EE L + E+EL + V L H + +
Sbjct: 1679 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1738
Query: 277 SQSNGFL--LPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGIS 334
SQ G + + + A + + +D ++ + L+ +++ S H +LEQ +
Sbjct: 1739 SQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDT-SAH--LERMKKNLEQTVK 1795
Query: 335 SLMERLH-----VMETQKKQERKV--RVKSPRTQVGSEYRES 369
L RL ++ KKQ +K+ RV+ +V SE + +
Sbjct: 1796 DLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1837
Score = 35.0 bits (79), Expect = 0.15
Identities = 60/310 (19%), Positives = 130/310 (41%), Gaps = 47/310 (15%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
E++ E + K +E K + Q L + ED+ L + + E+Q+
Sbjct: 984 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVN---TLTKAKIKLEQQV----D 1036
Query: 131 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDE 190
L+ S+E+ + ++ +L + K R L+G Q+ + QL ++L + +
Sbjct: 1037 DLEGSLEQEKKIRMDLERAK---RKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSG 1093
Query: 191 LHNQNVD-------LQRKLDERNRLLGEYKKEL---------GQKDRL-LQQHQAKLEEA 233
L ++ D LQ+K+ E + E ++E+ +K R L + ++ E
Sbjct: 1094 LQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1153
Query: 234 LRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATS 293
L + + Q+++ ++ E + M+R+ +EAT Q K A S
Sbjct: 1154 LEEAGGATSAQIEMNKKREAE----FQKMRRDLEEAT------LQHEATAATLRKKHADS 1203
Query: 294 VSNRG--TSDLQLVRDALRSLRNSF--------SGHDPQHHTIDSLEQGISSLMERLHVM 343
V+ G +LQ V+ L ++ S + +LE+ +L ++L +
Sbjct: 1204 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEI 1263
Query: 344 ETQKKQERKV 353
+T++++++++
Sbjct: 1264 KTKEEEQQRL 1273
Score = 34.3 bits (77), Expect = 0.25
Identities = 48/232 (20%), Positives = 99/232 (42%), Gaps = 45/232 (19%)
Query: 71 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 130
++L + E LE+E+E + S +A L + +E L E G Q+ + +
Sbjct: 1113 KELQARIEELEEEIEAERA--SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK 1170
Query: 131 RLDQSMEENQDLKKELLKCKQEAR------------------NLQGIKDALQQRLTQQDT 172
R + + +DL++ L+ + A NLQ +K L++ ++
Sbjct: 1171 REAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1230
Query: 173 SVLQLKQEL-----LRANMDK--DELHNQNVDLQRKLDERNRLL--------------GE 211
+ L + + N++K L +Q +++ K +E+ RL+ GE
Sbjct: 1231 EIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGE 1290
Query: 212 YKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMK 263
Y ++L +KD L+ Q + +++ ++ + LE E++ K LAH ++
Sbjct: 1291 YSRQLDEKDTLVSQLSRGKQAFTQQIEEL---KRQLEEEIKAKSA-LAHALQ 1338
Score = 32.7 bits (73), Expect = 0.73
Identities = 42/193 (21%), Positives = 92/193 (47%), Gaps = 15/193 (7%)
Query: 65 LETSWEEQLLEQQEYLEKEM---EEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP 121
LET + E ++ +++ E+AKK I+ A ++ L + EQ+ L N
Sbjct: 1734 LETDISQIQGEMEDIIQEARNAEEKAKKAIT--DAAMMAEELKK-EQDTSAHLERMKKNL 1790
Query: 122 EEQLIIIQSRLDQSME-ENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQE 180
E+ + +Q RLD++ + + KK++ K + R L+G ++ Q+R + + + +++
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERK 1850
Query: 181 LLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDR-------LLQQHQAKLEEA 233
+ +E + LQ +D+ + YK++ + + ++ Q +LEEA
Sbjct: 1851 VKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEA 1910
Query: 234 LRKLSDVSYHQVD 246
+ +D++ QV+
Sbjct: 1911 -EERADIAESQVN 1922
Score = 29.6 bits (65), Expect = 6.2
Identities = 45/219 (20%), Positives = 95/219 (43%), Gaps = 25/219 (11%)
Query: 68 SWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLP----EDEQERPLALCEPGVNPEE 123
++ +Q+ E + LE+E++ + LQ+ + L E+EQE L
Sbjct: 1311 AFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANS 1370
Query: 124 QLIIIQSRLD----QSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQ 179
++ +++ + Q EE ++ KK+L + Q+A +A+ + + + +L+
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHV---EAVNAKCASLEKTKQRLQN 1427
Query: 180 ELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKK---------ELGQKD-RLLQQHQAK 229
E+ +D + + L +K +++L E+K+ E QK+ R L K
Sbjct: 1428 EVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFK 1487
Query: 230 L----EEALRKLSDVSYHQVDLERELEHKDVLLAHCMKR 264
+ EE+L +L + +L++E+ +A KR
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1526
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 49.3 bits (116), Expect = 8e-06
Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 40/217 (18%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGL---------QALLLNGSLPEDEQERPLALCEPGVN 120
EEQ + Q+E E+E+E+ +++ G + + L + EQ+R L
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL------- 1732
Query: 121 PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIK-----------DALQQRLTQ 169
EE+L +Q + ++ Q+L+ EL K + E L K + +QRL
Sbjct: 1733 -EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 170 QDTSVLQLKQELLRANMDKDELHNQ----NVDLQRKLDERNRLLGEYKKELGQKDRL--- 222
+ +L +E R +E Q D R+ E R+L E +G+ RL
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 223 ----LQQHQAKLEEALRKLSDVSYHQVDLERE-LEHK 254
L++ +A+ E R D ++ + LE + +HK
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1888
Score = 36.2 bits (82), Expect = 0.066
Identities = 37/167 (22%), Positives = 71/167 (42%), Gaps = 27/167 (16%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
+E++ ++Q+ Q + + D ++ ++ L+ K+ LQQ + +LQLK E
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAER----LREAIAELEREKEKLQQ-----EAKLLQLKSEE 2475
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLE---------- 231
++ + L Q L E++ LL Q++R ++Q +AKLE
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLL--------QRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 232 EALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQ 278
+ LR+ Q++ ER+ + A + EA+E Q
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Score = 35.4 bits (80), Expect = 0.11
Identities = 40/176 (22%), Positives = 78/176 (44%), Gaps = 7/176 (3%)
Query: 65 LETSWEEQLLEQQEYLEKEMEE-AKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEE 123
LE + + QL ++E +E EE +K ++ + +E ER A E E
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 124 QLIIIQSRLDQSMEENQDLKKELLKCKQEARN--LQGIKDALQQRLTQQDTSVLQLKQEL 181
+ + + ++ Q+ ++ L+ +++A +Q + LQQ L Q+ + + QL+ E
Sbjct: 2027 RA---EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL 237
A +E V +R+ + R + E ++ L Q Q +A+ + A KL
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL 2138
Score = 34.7 bits (78), Expect = 0.19
Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 28/164 (17%)
Query: 68 SWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLII 127
S E Q ++Q++ L++ + +S +LL E E+ + L + V +QL
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 128 IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD 187
Q R Q ME+ ++ L+ +EAR +R + + V + ++EL
Sbjct: 2533 EQQRQQQQMEQE---RQRLVASMEEAR----------RRQHEAEEGVRRKQEEL------ 2573
Query: 188 KDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLL-QQHQAKL 230
Q ++ QR+ ++ LL E + L ++ +LL +QH+A L
Sbjct: 2574 ------QQLEQQRR--QQEELLAEENQRLREQLQLLEEQHRAAL 2609
Score = 29.6 bits (65), Expect = 6.2
Identities = 45/198 (22%), Positives = 87/198 (43%), Gaps = 16/198 (8%)
Query: 72 QLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP--EEQLIIIQ 129
+L Q++ + E ++ S A L ++ E E+E+ E + E++ +Q
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2480
Query: 130 SRLDQSMEENQDLKKELLKCK----QEARNLQGIKDALQQRLTQQDTSVLQLKQELLRAN 185
+Q ++E Q L++ L K Q R ++ K L+Q + QL++E R
Sbjct: 2481 Q--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-- 2536
Query: 186 MDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQ---HQAKLEEALRKLSDVSY 242
+ ++ + L ++E R E ++ + +K LQQ + + EE L + +
Sbjct: 2537 -QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 243 HQVDLERELEHKDVLLAH 260
Q+ L E +H+ LAH
Sbjct: 2596 EQLQLLEE-QHR-AALAH 2611
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 49.3 bits (116), Expect = 8e-06
Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 40/217 (18%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGL---------QALLLNGSLPEDEQERPLALCEPGVN 120
EEQ + Q+E E+E+E+ +++ G + + L + EQ+R L
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL------- 1736
Query: 121 PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIK-----------DALQQRLTQ 169
EE+L +Q + ++ Q+L+ EL K + E L K + +QRL
Sbjct: 1737 -EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Query: 170 QDTSVLQLKQELLRANMDKDELHNQ----NVDLQRKLDERNRLLGEYKKELGQKDRL--- 222
+ +L +E R +E Q D R+ E R+L E +G+ RL
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1855
Query: 223 ----LQQHQAKLEEALRKLSDVSYHQVDLERE-LEHK 254
L++ +A+ E R D ++ + LE + +HK
Sbjct: 1856 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1892
Score = 36.2 bits (82), Expect = 0.066
Identities = 37/167 (22%), Positives = 71/167 (42%), Gaps = 27/167 (16%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
+E++ ++Q+ Q + + D ++ ++ L+ K+ LQQ + +LQLK E
Sbjct: 2429 QEKVTLVQTLEIQRQQSDHDAER----LREAIAELEREKEKLQQ-----EAKLLQLKSEE 2479
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLE---------- 231
++ + L Q L E++ LL Q++R ++Q +AKLE
Sbjct: 2480 MQTVQQEQLLQETQALQQSFLSEKDSLL--------QRERFIEQEKAKLEQLFQDEVAKA 2531
Query: 232 EALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQ 278
+ LR+ Q++ ER+ + A + EA+E Q
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578
Score = 35.4 bits (80), Expect = 0.11
Identities = 40/176 (22%), Positives = 78/176 (44%), Gaps = 7/176 (3%)
Query: 65 LETSWEEQLLEQQEYLEKEMEE-AKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEE 123
LE + + QL ++E +E EE +K ++ + +E ER A E E
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030
Query: 124 QLIIIQSRLDQSMEENQDLKKELLKCKQEARN--LQGIKDALQQRLTQQDTSVLQLKQEL 181
+ + + ++ Q+ ++ L+ +++A +Q + LQQ L Q+ + + QL+ E
Sbjct: 2031 RA---EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL 237
A +E V +R+ + R + E ++ L Q Q +A+ + A KL
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL 2142
Score = 34.7 bits (78), Expect = 0.19
Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 28/164 (17%)
Query: 68 SWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLII 127
S E Q ++Q++ L++ + +S +LL E E+ + L + V +QL
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536
Query: 128 IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD 187
Q R Q ME+ ++ L+ +EAR +R + + V + ++EL
Sbjct: 2537 EQQRQQQQMEQE---RQRLVASMEEAR----------RRQHEAEEGVRRKQEEL------ 2577
Query: 188 KDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLL-QQHQAKL 230
Q ++ QR+ ++ LL E + L ++ +LL +QH+A L
Sbjct: 2578 ------QQLEQQRR--QQEELLAEENQRLREQLQLLEEQHRAAL 2613
Score = 29.6 bits (65), Expect = 6.2
Identities = 45/198 (22%), Positives = 87/198 (43%), Gaps = 16/198 (8%)
Query: 72 QLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP--EEQLIIIQ 129
+L Q++ + E ++ S A L ++ E E+E+ E + E++ +Q
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2484
Query: 130 SRLDQSMEENQDLKKELLKCK----QEARNLQGIKDALQQRLTQQDTSVLQLKQELLRAN 185
+Q ++E Q L++ L K Q R ++ K L+Q + QL++E R
Sbjct: 2485 Q--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-- 2540
Query: 186 MDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQ---HQAKLEEALRKLSDVSY 242
+ ++ + L ++E R E ++ + +K LQQ + + EE L + +
Sbjct: 2541 -QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2599
Query: 243 HQVDLERELEHKDVLLAH 260
Q+ L E +H+ LAH
Sbjct: 2600 EQLQLLEE-QHR-AALAH 2615
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 49.3 bits (116), Expect = 8e-06
Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 40/217 (18%)
Query: 70 EEQLLEQQEYLEKEMEEAKKMISGL---------QALLLNGSLPEDEQERPLALCEPGVN 120
EEQ + Q+E E+E+E+ +++ G + + L + EQ+R L
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL------- 1732
Query: 121 PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIK-----------DALQQRLTQ 169
EE+L +Q + ++ Q+L+ EL K + E L K + +QRL
Sbjct: 1733 -EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 170 QDTSVLQLKQELLRANMDKDELHNQ----NVDLQRKLDERNRLLGEYKKELGQKDRL--- 222
+ +L +E R +E Q D R+ E R+L E +G+ RL
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 223 ----LQQHQAKLEEALRKLSDVSYHQVDLERE-LEHK 254
L++ +A+ E R D ++ + LE + +HK
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1888
Score = 36.2 bits (82), Expect = 0.066
Identities = 37/167 (22%), Positives = 71/167 (42%), Gaps = 27/167 (16%)
Query: 122 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 181
+E++ ++Q+ Q + + D ++ ++ L+ K+ LQQ + +LQLK E
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAER----LREAIAELEREKEKLQQ-----EAKLLQLKSEE 2475
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLE---------- 231
++ + L Q L E++ LL Q++R ++Q +AKLE
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLL--------QRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 232 EALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQ 278
+ LR+ Q++ ER+ + A + EA+E Q
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Score = 35.4 bits (80), Expect = 0.11
Identities = 40/176 (22%), Positives = 78/176 (44%), Gaps = 7/176 (3%)
Query: 65 LETSWEEQLLEQQEYLEKEMEE-AKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEE 123
LE + + QL ++E +E EE +K ++ + +E ER A E E
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 124 QLIIIQSRLDQSMEENQDLKKELLKCKQEARN--LQGIKDALQQRLTQQDTSVLQLKQEL 181
+ + + ++ Q+ ++ L+ +++A +Q + LQQ L Q+ + + QL+ E
Sbjct: 2027 RA---EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 182 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL 237
A +E V +R+ + R + E ++ L Q Q +A+ + A KL
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL 2138
Score = 34.7 bits (78), Expect = 0.19
Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 28/164 (17%)
Query: 68 SWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLII 127
S E Q ++Q++ L++ + +S +LL E E+ + L + V +QL
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 128 IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD 187
Q R Q ME+ ++ L+ +EAR +R + + V + ++EL
Sbjct: 2533 EQQRQQQQMEQE---RQRLVASMEEAR----------RRQHEAEEGVRRKQEEL------ 2573
Query: 188 KDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLL-QQHQAKL 230
Q ++ QR+ ++ LL E + L ++ +LL +QH+A L
Sbjct: 2574 ------QQLEQQRR--QQEELLAEENQRLREQLQLLEEQHRAAL 2609
Score = 29.6 bits (65), Expect = 6.2
Identities = 45/198 (22%), Positives = 87/198 (43%), Gaps = 16/198 (8%)
Query: 72 QLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP--EEQLIIIQ 129
+L Q++ + E ++ S A L ++ E E+E+ E + E++ +Q
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2480
Query: 130 SRLDQSMEENQDLKKELLKCK----QEARNLQGIKDALQQRLTQQDTSVLQLKQELLRAN 185
+Q ++E Q L++ L K Q R ++ K L+Q + QL++E R
Sbjct: 2481 Q--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-- 2536
Query: 186 MDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQ---HQAKLEEALRKLSDVSY 242
+ ++ + L ++E R E ++ + +K LQQ + + EE L + +
Sbjct: 2537 -QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 243 HQVDLERELEHKDVLLAH 260
Q+ L E +H+ LAH
Sbjct: 2596 EQLQLLEE-QHR-AALAH 2611
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,775,442
Number of Sequences: 37866
Number of extensions: 884617
Number of successful extensions: 6776
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 212
Number of HSP's successfully gapped in prelim test: 659
Number of HSP's that attempted gapping in prelim test: 3976
Number of HSP's gapped (non-prelim): 2583
length of query: 472
length of database: 18,247,518
effective HSP length: 106
effective length of query: 366
effective length of database: 14,233,722
effective search space: 5209542252
effective search space used: 5209542252
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.