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Search of human proteins with 39752689
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39752689 MAP kinase-interacting serine/threonine kinase 1
isoform 2 [Homo sapiens]
(347 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39752689 MAP kinase-interacting serine/threonine kinase 1 iso... 709 0.0
gi|207113186 MAP kinase-interacting serine/threonine kinase 1 is... 686 0.0
gi|21361101 MAP kinase-interacting serine/threonine kinase 1 iso... 666 0.0
gi|40018627 MAP kinase-interacting serine/threonine kinase 2 iso... 530 e-151
gi|40018631 MAP kinase-interacting serine/threonine kinase 2 iso... 530 e-151
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 186 3e-47
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 186 3e-47
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 185 6e-47
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 185 6e-47
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 181 1e-45
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 180 1e-45
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 180 1e-45
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 178 6e-45
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 177 9e-45
gi|4758700 mitogen-activated protein kinase-activated protein ki... 175 6e-44
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 173 2e-43
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 171 7e-43
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 171 1e-42
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 171 1e-42
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 171 1e-42
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 171 1e-42
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 168 6e-42
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 168 6e-42
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 168 6e-42
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 168 6e-42
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 168 6e-42
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 168 6e-42
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 168 6e-42
gi|27901803 protein serine kinase H1 [Homo sapiens] 168 6e-42
gi|32481209 mitogen-activated protein kinase-activated protein k... 166 2e-41
>gi|39752689 MAP kinase-interacting serine/threonine kinase 1
isoform 2 [Homo sapiens]
Length = 347
Score = 709 bits (1830), Expect = 0.0
Identities = 347/347 (100%), Positives = 347/347 (100%)
Query: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
Sbjct: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
Query: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
Sbjct: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
Query: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES 180
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
Sbjct: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES 180
Query: 181 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 240
PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
Sbjct: 181 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 240
Query: 241 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 300
CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
Sbjct: 241 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 300
Query: 301 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGEQQHNGPDALRS 347
HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGEQQHNGPDALRS
Sbjct: 301 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGEQQHNGPDALRS 347
>gi|207113186 MAP kinase-interacting serine/threonine kinase 1
isoform 3 [Homo sapiens]
Length = 424
Score = 686 bits (1771), Expect = 0.0
Identities = 336/341 (98%), Positives = 337/341 (98%)
Query: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
Sbjct: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
Query: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
Sbjct: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
Query: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES 180
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
Sbjct: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES 180
Query: 181 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 240
PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
Sbjct: 181 PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR 240
Query: 241 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 300
CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
Sbjct: 241 CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA 300
Query: 301 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGEQQHNG 341
HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQG+ G
Sbjct: 301 HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKG 341
>gi|21361101 MAP kinase-interacting serine/threonine kinase 1
isoform 1 [Homo sapiens]
Length = 465
Score = 666 bits (1719), Expect = 0.0
Identities = 336/382 (87%), Positives = 337/382 (88%), Gaps = 41/382 (10%)
Query: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
Sbjct: 1 MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY 60
Query: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
Sbjct: 61 AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF 120
Query: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK---------------- 164
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK
Sbjct: 121 YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS 180
Query: 165 -------------------------GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 199
GIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
Sbjct: 181 GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK 240
Query: 200 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 259
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
Sbjct: 241 LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP 300
Query: 260 FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK 319
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
Sbjct: 301 FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK 360
Query: 320 QRLSAAQVLQHPWVQGEQQHNG 341
QRLSAAQVLQHPWVQG+ G
Sbjct: 361 QRLSAAQVLQHPWVQGQAPEKG 382
>gi|40018627 MAP kinase-interacting serine/threonine kinase 2
isoform 2 [Homo sapiens]
Length = 465
Score = 530 bits (1366), Expect = e-151
Identities = 248/324 (76%), Positives = 287/324 (88%)
Query: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQN 71
+M +S+P+ I D +R KKK+RGRATDS G+FED+Y+L ++LGEGA+A+VQ ++L
Sbjct: 47 DMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLIT 106
Query: 72 GKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGS 131
+EYAVKIIEKQ GH RSRVFREVE LYQCQG++N+LELIEFFE++ RFYLVFEK++GGS
Sbjct: 107 SQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGS 166
Query: 132 ILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICD 191
IL+HI K++HFNE EAS VV+DVA+ALDFLH KGIAHRDLKPENILCE P +VSPVKICD
Sbjct: 167 ILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICD 226
Query: 192 FDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLY 251
FDLGSG+KLN C+PI+TPEL TPCGSAEYMAPEVVE F+++A+ YDKRCDLWSLGV+LY
Sbjct: 227 FDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILY 286
Query: 252 IMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLIS 311
I+LSGYPPFVG CG+DCGWDRGE C CQN LFESIQEGKYEFPDKDWAHIS AKDLIS
Sbjct: 287 ILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLIS 346
Query: 312 KLLVRDAKQRLSAAQVLQHPWVQG 335
KLLVRDAKQRLSAAQVLQHPWVQG
Sbjct: 347 KLLVRDAKQRLSAAQVLQHPWVQG 370
>gi|40018631 MAP kinase-interacting serine/threonine kinase 2
isoform 1 [Homo sapiens]
Length = 414
Score = 530 bits (1366), Expect = e-151
Identities = 248/324 (76%), Positives = 287/324 (88%)
Query: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQN 71
+M +S+P+ I D +R KKK+RGRATDS G+FED+Y+L ++LGEGA+A+VQ ++L
Sbjct: 47 DMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLIT 106
Query: 72 GKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGS 131
+EYAVKIIEKQ GH RSRVFREVE LYQCQG++N+LELIEFFE++ RFYLVFEK++GGS
Sbjct: 107 SQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGS 166
Query: 132 ILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICD 191
IL+HI K++HFNE EAS VV+DVA+ALDFLH KGIAHRDLKPENILCE P +VSPVKICD
Sbjct: 167 ILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICD 226
Query: 192 FDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLY 251
FDLGSG+KLN C+PI+TPEL TPCGSAEYMAPEVVE F+++A+ YDKRCDLWSLGV+LY
Sbjct: 227 FDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILY 286
Query: 252 IMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLIS 311
I+LSGYPPFVG CG+DCGWDRGE C CQN LFESIQEGKYEFPDKDWAHIS AKDLIS
Sbjct: 287 ILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLIS 346
Query: 312 KLLVRDAKQRLSAAQVLQHPWVQG 335
KLLVRDAKQRLSAAQVLQHPWVQG
Sbjct: 347 KLLVRDAKQRLSAAQVLQHPWVQG 370
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 186 bits (472), Expect = 3e-47
Identities = 116/315 (36%), Positives = 170/315 (53%), Gaps = 33/315 (10%)
Query: 23 DGDRRRKKKRRGRATDSLPGK---FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKI 79
DG R + L GK F D Y + E +G G+Y++ + V EYAVK+
Sbjct: 399 DGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKV 457
Query: 80 IEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQ 139
I+K S+ E+E L + + NI+ L + ++D YLV E ++GG +L I +Q
Sbjct: 458 IDK----SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQ 513
Query: 140 KHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGM 198
K F+EREAS V+ + +++LH++G+ HRDLKP NIL + ++ICDF +
Sbjct: 514 KFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL 573
Query: 199 KLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYP 258
+ N L TPC +A ++APEV+ + YD+ CD+WSLG++LY ML+GY
Sbjct: 574 RAENGL-------LMTPCYTANFVAPEVL-----KRQGYDEGCDIWSLGILLYTMLAGYT 621
Query: 259 PFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDA 318
PF A+ D E ++ I GK+ +W +S AKDL+SK+L D
Sbjct: 622 PF-----ANGPSDTPE-------EILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 669
Query: 319 KQRLSAAQVLQHPWV 333
QRL+A QVLQHPWV
Sbjct: 670 HQRLTAKQVLQHPWV 684
Score = 102 bits (253), Expect = 7e-22
Identities = 80/276 (28%), Positives = 134/276 (48%), Gaps = 38/276 (13%)
Query: 53 ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
++LG+G++ KV + +G YA+K+++K R RV ++E N +
Sbjct: 75 KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 134
Query: 110 LIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAH 168
+ + F+ + + YL+ + L+GG + + K+ F E + + ++A LD LH+ GI +
Sbjct: 135 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 194
Query: 169 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 228
RDLKPENIL ++ +K+ DF L S +++ + + CG+ EYMAPEVV
Sbjct: 195 RDLKPENILL---DEEGHIKLTDFGL-SKEAIDHE------KKAYSFCGTVEYMAPEVV- 243
Query: 229 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 288
+ D WS GV+++ ML+G PF G DR E + I
Sbjct: 244 ----NRQGHSHSADWWSYGVLMFEMLTGSLPFQGK-------DRKETMTL--------IL 284
Query: 289 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSA 324
+ K P +S+EA+ L+ L R+ RL +
Sbjct: 285 KAKLGMPQ----FLSTEAQSLLRALFKRNPANRLGS 316
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 186 bits (472), Expect = 3e-47
Identities = 116/315 (36%), Positives = 170/315 (53%), Gaps = 33/315 (10%)
Query: 23 DGDRRRKKKRRGRATDSLPGK---FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKI 79
DG R + L GK F D Y + E +G G+Y++ + V EYAVK+
Sbjct: 390 DGKPRAPQAPLHSVVQQLHGKNLVFSDGY-VVKETIGVGSYSECKRCVHKATNMEYAVKV 448
Query: 80 IEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQ 139
I+K S+ E+E L + + NI+ L + ++D YLV E ++GG +L I +Q
Sbjct: 449 IDK----SKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQ 504
Query: 140 KHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGM 198
K F+EREAS V+ + +++LH++G+ HRDLKP NIL + ++ICDF +
Sbjct: 505 KFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQL 564
Query: 199 KLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYP 258
+ N L TPC +A ++APEV+ + YD+ CD+WSLG++LY ML+GY
Sbjct: 565 RAENGL-------LMTPCYTANFVAPEVL-----KRQGYDEGCDIWSLGILLYTMLAGYT 612
Query: 259 PFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDA 318
PF A+ D E ++ I GK+ +W +S AKDL+SK+L D
Sbjct: 613 PF-----ANGPSDTPE-------EILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 660
Query: 319 KQRLSAAQVLQHPWV 333
QRL+A QVLQHPWV
Sbjct: 661 HQRLTAKQVLQHPWV 675
Score = 102 bits (253), Expect = 7e-22
Identities = 80/276 (28%), Positives = 134/276 (48%), Gaps = 38/276 (13%)
Query: 53 ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
++LG+G++ KV + +G YA+K+++K R RV ++E N +
Sbjct: 66 KVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 125
Query: 110 LIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAH 168
+ + F+ + + YL+ + L+GG + + K+ F E + + ++A LD LH+ GI +
Sbjct: 126 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIY 185
Query: 169 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 228
RDLKPENIL ++ +K+ DF L S +++ + + CG+ EYMAPEVV
Sbjct: 186 RDLKPENILL---DEEGHIKLTDFGL-SKEAIDHE------KKAYSFCGTVEYMAPEVV- 234
Query: 229 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 288
+ D WS GV+++ ML+G PF G DR E + I
Sbjct: 235 ----NRQGHSHSADWWSYGVLMFEMLTGSLPFQGK-------DRKETMTL--------IL 275
Query: 289 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSA 324
+ K P +S+EA+ L+ L R+ RL +
Sbjct: 276 KAKLGMPQ----FLSTEAQSLLRALFKRNPANRLGS 307
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 185 bits (469), Expect = 6e-47
Identities = 112/292 (38%), Positives = 165/292 (56%), Gaps = 32/292 (10%)
Query: 44 FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQG 103
F D Y++ ++ G G+Y+ + V EYAVKII+K S+ E+E L +
Sbjct: 419 FTDGYEIKEDI-GVGSYSVCKRCVHKATDTEYAVKIIDK----SKRDPSEEIEILLRYGQ 473
Query: 104 NKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHT 163
+ NI+ L + ++D YLV E ++GG +L I +Q++F+EREAS V+ + +D+LH+
Sbjct: 474 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 533
Query: 164 KGIAHRDLKPENILCESPEKVSP--VKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
+G+ HRDLKP NIL E SP +++CDF ++ N L TPC +A +
Sbjct: 534 QGVVHRDLKPSNILYRD-ESGSPESIRVCDFGFAKQLRAGNGL-------LMTPCYTANF 585
Query: 222 MAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQN 281
+APEV+ + YD CD+WSLG++LY ML+G+ PF G D D E
Sbjct: 586 VAPEVL-----KRQGYDAACDIWSLGILLYTMLAGFTPFAN--GPD---DTPE------- 628
Query: 282 KLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
++ I GKY +W IS AKD++SK+L D QRL+A QVL+HPWV
Sbjct: 629 EILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV 680
Score = 108 bits (271), Expect = 5e-24
Identities = 88/301 (29%), Positives = 144/301 (47%), Gaps = 48/301 (15%)
Query: 41 PGKFEDMYKLTSELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVET 97
P +FE + ++LG+G+Y KV + G+ YA+K+++K R RV ++E
Sbjct: 64 PSQFELL-----KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMER 118
Query: 98 LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
+ N + + + F+ + + YL+ + L+GG + + K+ F E + + ++A
Sbjct: 119 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 178
Query: 157 ALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPC 216
ALD LH+ GI +RDLKPENIL ++ +KI DF L ++ + C
Sbjct: 179 ALDHLHSLGIIYRDLKPENILL---DEEGHIKITDFGLSKEAIDHDK-------RAYSFC 228
Query: 217 GSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 276
G+ EYMAPEVV + + D WS GV+++ ML+G PF G DR E
Sbjct: 229 GTIEYMAPEVV-----NRRGHTQSADWWSFGVLMFEMLTGSLPFQGK-------DRKETM 276
Query: 277 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHP 331
+ I + K P +S EA+ L+ L R+ RL A ++ +HP
Sbjct: 277 AL--------ILKAKLGMPQ----FLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHP 324
Query: 332 W 332
+
Sbjct: 325 F 325
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 185 bits (469), Expect = 6e-47
Identities = 112/292 (38%), Positives = 165/292 (56%), Gaps = 32/292 (10%)
Query: 44 FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQG 103
F D Y++ ++ G G+Y+ + V EYAVKII+K S+ E+E L +
Sbjct: 411 FTDGYEIKEDI-GVGSYSVCKRCVHKATDTEYAVKIIDK----SKRDPSEEIEILLRYGQ 465
Query: 104 NKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHT 163
+ NI+ L + ++D YLV E ++GG +L I +Q++F+EREAS V+ + +D+LH+
Sbjct: 466 HPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHS 525
Query: 164 KGIAHRDLKPENILCESPEKVSP--VKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
+G+ HRDLKP NIL E SP +++CDF ++ N L TPC +A +
Sbjct: 526 QGVVHRDLKPSNILYRD-ESGSPESIRVCDFGFAKQLRAGNGL-------LMTPCYTANF 577
Query: 222 MAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQN 281
+APEV+ + YD CD+WSLG++LY ML+G+ PF G D D E
Sbjct: 578 VAPEVL-----KRQGYDAACDIWSLGILLYTMLAGFTPFAN--GPD---DTPE------- 620
Query: 282 KLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
++ I GKY +W IS AKD++SK+L D QRL+A QVL+HPWV
Sbjct: 621 EILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV 672
Score = 108 bits (271), Expect = 5e-24
Identities = 88/301 (29%), Positives = 144/301 (47%), Gaps = 48/301 (15%)
Query: 41 PGKFEDMYKLTSELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVET 97
P +FE + ++LG+G+Y KV + G+ YA+K+++K R RV ++E
Sbjct: 56 PSQFELL-----KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMER 110
Query: 98 LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
+ N + + + F+ + + YL+ + L+GG + + K+ F E + + ++A
Sbjct: 111 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 170
Query: 157 ALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPC 216
ALD LH+ GI +RDLKPENIL ++ +KI DF L ++ + C
Sbjct: 171 ALDHLHSLGIIYRDLKPENILL---DEEGHIKITDFGLSKEAIDHDK-------RAYSFC 220
Query: 217 GSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 276
G+ EYMAPEVV + + D WS GV+++ ML+G PF G DR E
Sbjct: 221 GTIEYMAPEVV-----NRRGHTQSADWWSFGVLMFEMLTGSLPFQGK-------DRKETM 268
Query: 277 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHP 331
+ I + K P +S EA+ L+ L R+ RL A ++ +HP
Sbjct: 269 AL--------ILKAKLGMPQ----FLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHP 316
Query: 332 W 332
+
Sbjct: 317 F 317
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 181 bits (458), Expect = 1e-45
Identities = 106/294 (36%), Positives = 157/294 (53%), Gaps = 24/294 (8%)
Query: 50 LTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
L + LGEG+++ + V ++ + +AVKII K+ + +E+ L C+G+ NI++
Sbjct: 427 LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRM---EANTQKEITALKLCEGHPNIVK 483
Query: 110 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHR 169
L E F D +LV E L GG + I+K+KHF+E EAS ++R + +A+ +H G+ HR
Sbjct: 484 LHEVFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHR 543
Query: 170 DLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEV 229
DLKPEN+L +KI DF P L TPC + Y APE++
Sbjct: 544 DLKPENLLFTDENDNLEIKIIDFGFA-------RLKPPDNQPLKTPCFTLHYAAPELL-- 594
Query: 230 FTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQE 289
YD+ CDLWSLGV+LY MLSG PF H DR C ++ + I++
Sbjct: 595 ---NQNGYDESCDLWSLGVILYTMLSGQVPFQSH-------DRSLTC-TSAVEIMKKIKK 643
Query: 290 GKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ-GEQQHNGP 342
G + F + W ++S EAKDLI LL D +RL + + + W+Q G Q + P
Sbjct: 644 GDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNP 697
Score = 115 bits (289), Expect = 4e-26
Identities = 87/294 (29%), Positives = 147/294 (50%), Gaps = 39/294 (13%)
Query: 53 ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEK----QAGHSRSRVFREVETLYQCQGNK 105
++LG GAY KV + GK YA+K+++K Q + E + L + +
Sbjct: 53 KVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSP 112
Query: 106 NILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKG 165
++ L F+ +T+ +L+ + + GG + H+ +++ F E E V ++ AL+ LH G
Sbjct: 113 FLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLG 172
Query: 166 IAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPE 225
I +RD+K ENIL +S V + DF L + T + CG+ EYMAP+
Sbjct: 173 IIYRDIKLENILLDSN---GHVVLTDFGLSKEFVADE------TERAYSFCGTIEYMAPD 223
Query: 226 VVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFE 285
+V + +DK D WSLGV++Y +L+G PF GE + Q ++
Sbjct: 224 IVR---GGDSGHDKAVDWWSLGVLMYELLTGASPFTVD---------GE--KNSQAEISR 269
Query: 286 SIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRL-----SAAQVLQHPWVQ 334
I + + +P + +S+ AKDLI +LL++D K+RL A ++ +H + Q
Sbjct: 270 RILKSEPPYPQE----MSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQ 319
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 180 bits (457), Expect = 1e-45
Identities = 106/294 (36%), Positives = 163/294 (55%), Gaps = 23/294 (7%)
Query: 50 LTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
L LG+G+++ + Q+G+E+AVKI+ ++ + REV L CQ + N++
Sbjct: 406 LREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRL---EANTQREVAALRLCQSHPNVVN 462
Query: 110 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK-GIAH 168
L E D YLV E L+GG +L HI+K++HF+E EAS+++R + +A+ F+H + G+ H
Sbjct: 463 LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVH 522
Query: 169 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 228
RDLKPENIL +PVKI DF + ++ + P + TPC + +Y APE++
Sbjct: 523 RDLKPENILYADDTPGAPVKIIDFGF-ARLRPQSPGVP-----MQTPCFTLQYAAPELL- 575
Query: 229 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 288
YD+ CDLWSLGV+LY+MLSG PF G G E+ +C+ I+
Sbjct: 576 ----AQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEI--MCK------IR 623
Query: 289 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGEQQHNGP 342
EG++ + W +S EAK+L+ LL D +RL + W+Q + P
Sbjct: 624 EGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSP 677
Score = 114 bits (285), Expect = 1e-25
Identities = 89/301 (29%), Positives = 142/301 (47%), Gaps = 52/301 (17%)
Query: 53 ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
++LG GAY KV + A GK YA+K++ K A R++ T +++LE
Sbjct: 37 KVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRT------ERSVLE 90
Query: 110 LIE----------FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
L+ F+ D + +L+ + + GG + H+ ++++F E E ++ AL+
Sbjct: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
Query: 160 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219
LH GI +RDLK EN+L +S + + DF L + CG+
Sbjct: 151 HLHKLGIIYRDLKLENVLLDSE---GHIVLTDFGLSKEFLTEEK------ERTFSFCGTI 201
Query: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279
EYMAPE++ T + K D WSLG++L+ +L+G PF GE R
Sbjct: 202 EYMAPEIIR----SKTGHGKAVDWWSLGILLFELLTGASPFT---------LEGE--RNT 246
Query: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHPWVQ 334
Q ++ I + FP + I A+DL+ +LL +D K+RL A +V HP+ Q
Sbjct: 247 QAEVSRRILKCSPPFPPR----IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQ 302
Query: 335 G 335
G
Sbjct: 303 G 303
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 180 bits (457), Expect = 1e-45
Identities = 106/294 (36%), Positives = 163/294 (55%), Gaps = 23/294 (7%)
Query: 50 LTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
L LG+G+++ + Q+G+E+AVKI+ ++ + REV L CQ + N++
Sbjct: 412 LREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRL---EANTQREVAALRLCQSHPNVVN 468
Query: 110 LIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK-GIAH 168
L E D YLV E L+GG +L HI+K++HF+E EAS+++R + +A+ F+H + G+ H
Sbjct: 469 LHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVH 528
Query: 169 RDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVE 228
RDLKPENIL +PVKI DF + ++ + P + TPC + +Y APE++
Sbjct: 529 RDLKPENILYADDTPGAPVKIIDFGF-ARLRPQSPGVP-----MQTPCFTLQYAAPELL- 581
Query: 229 VFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQ 288
YD+ CDLWSLGV+LY+MLSG PF G G E+ +C+ I+
Sbjct: 582 ----AQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEI--MCK------IR 629
Query: 289 EGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGEQQHNGP 342
EG++ + W +S EAK+L+ LL D +RL + W+Q + P
Sbjct: 630 EGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSP 683
Score = 114 bits (285), Expect = 1e-25
Identities = 89/301 (29%), Positives = 142/301 (47%), Gaps = 52/301 (17%)
Query: 53 ELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILE 109
++LG GAY KV + A GK YA+K++ K A R++ T +++LE
Sbjct: 37 KVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRT------ERSVLE 90
Query: 110 LIE----------FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
L+ F+ D + +L+ + + GG + H+ ++++F E E ++ AL+
Sbjct: 91 LVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALE 150
Query: 160 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219
LH GI +RDLK EN+L +S + + DF L + CG+
Sbjct: 151 HLHKLGIIYRDLKLENVLLDSE---GHIVLTDFGLSKEFLTEEK------ERTFSFCGTI 201
Query: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279
EYMAPE++ T + K D WSLG++L+ +L+G PF GE R
Sbjct: 202 EYMAPEIIR----SKTGHGKAVDWWSLGILLFELLTGASPFT---------LEGE--RNT 246
Query: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAA-----QVLQHPWVQ 334
Q ++ I + FP + I A+DL+ +LL +D K+RL A +V HP+ Q
Sbjct: 247 QAEVSRRILKCSPPFPPR----IGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQ 302
Query: 335 G 335
G
Sbjct: 303 G 303
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 178 bits (452), Expect = 6e-45
Identities = 104/283 (36%), Positives = 155/283 (54%), Gaps = 30/283 (10%)
Query: 53 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIE 112
E+LG GA+++V GK +A+K I+K S + E+ L + + ++NI+ L +
Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIK-HENIVTLED 85
Query: 113 FFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLK 172
+E T +YLV + + GG + I ++ + E++AS V++ V +A+ +LH GI HRDLK
Sbjct: 86 IYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLK 145
Query: 173 PENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTD 232
PEN+L +PE+ S + I DF L S M+ N ++T CG+ Y+APEV+
Sbjct: 146 PENLLYLTPEENSKIMITDFGL-SKMEQNGI--------MSTACGTPGYVAPEVL----- 191
Query: 233 QATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKY 292
Y K D WS+GV+ YI+L GYPPF ++KLFE I+EG Y
Sbjct: 192 AQKPYSKAVDCWSIGVITYILLCGYPPFY---------------EETESKLFEKIKEGYY 236
Query: 293 EFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQG 335
EF W IS AKD I LL +D +R + + L HPW+ G
Sbjct: 237 EFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDG 279
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 177 bits (450), Expect = 9e-45
Identities = 107/292 (36%), Positives = 161/292 (55%), Gaps = 30/292 (10%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ 102
+F D Y++ ++ G G+Y+ + + E+AVKII+K S+ E+E L +
Sbjct: 417 QFTDGYEVKEDI-GVGSYSVCKRCIHKATNMEFAVKIIDK----SKRDPTEEIEILLRYG 471
Query: 103 GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 162
+ NI+ L + ++D Y+V E ++GG +L I +QK F+EREAS V+ + +++LH
Sbjct: 472 QHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLH 531
Query: 163 TKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
+G+ HRDLKP NIL + ++ICDF ++ N L TPC +A +
Sbjct: 532 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGL-------LMTPCYTANF 584
Query: 222 MAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQN 281
+APEV+ + YD CD+WSLGV+LY ML+GY PF G D D E
Sbjct: 585 VAPEVL-----KRQGYDAACDIWSLGVLLYTMLTGYTPFAN--GPD---DTPE------- 627
Query: 282 KLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
++ I GK+ W +S AKDL+SK+L D QRL+AA VL+HPW+
Sbjct: 628 EILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
Score = 103 bits (258), Expect = 2e-22
Identities = 85/288 (29%), Positives = 143/288 (49%), Gaps = 43/288 (14%)
Query: 41 PGKFEDMYKLTSELLGEGAYAKV--QGAVSLQNGKE-YAVKIIEKQAGHSRSRVFREVET 97
P +FE + ++LG+G++ KV +S + ++ YA+K+++K R RV ++E
Sbjct: 65 PSQFELL-----KVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMER 119
Query: 98 LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
+ N + + + F+ + + YL+ + L+GG + + K+ F E + + ++A
Sbjct: 120 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELAL 179
Query: 157 ALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPC 216
ALD LH+ GI +RDLKPENIL ++ +K+ DF L S +++ + + C
Sbjct: 180 ALDHLHSLGIIYRDLKPENILL---DEEGHIKLTDFGL-SKESIDHE------KKAYSFC 229
Query: 217 GSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 276
G+ EYMAPEVV + + D WS GV+++ ML+G PF G DR E
Sbjct: 230 GTVEYMAPEVV-----NRRGHTQSADWWSFGVLMFEMLTGTLPFQGK-------DRKETM 277
Query: 277 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSA 324
+ I + K P +S EA+ L+ L R+ RL A
Sbjct: 278 TM--------ILKAKLGMPQ----FLSPEAQSLLRMLFKRNPANRLGA 313
>gi|4758700 mitogen-activated protein kinase-activated protein
kinase 3 [Homo sapiens]
Length = 382
Score = 175 bits (443), Expect = 6e-44
Identities = 107/330 (32%), Positives = 173/330 (52%), Gaps = 41/330 (12%)
Query: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFE--DMYKLTSELLGEGAYAKVQGAVSL 69
E G P P+A G GR P K+ D Y+L+ ++LG G KV
Sbjct: 8 EQGGPVPPPVAPGGPGLGGAPGGRRE---PKKYAVTDDYQLSKQVLGLGVNGKVLECFHR 64
Query: 70 QNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTR----FYLVFE 125
+ G++ A+K++ + + +EV+ +Q G +I+ +++ +E+ ++ E
Sbjct: 65 RTGQKCALKLL-----YDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIME 119
Query: 126 KLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEK 183
++GG + + IQ++ + F EREA+ ++RD+ A+ FLH+ IAHRD+KPEN+L S EK
Sbjct: 120 CMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEK 179
Query: 184 VSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDL 243
+ +K+ DF T L TPC + Y+APEV+ YDK CD+
Sbjct: 180 DAVLKLTDFGFAK---------ETTQNALQTPCYTPYYVAPEVL-----GPEKYDKSCDM 225
Query: 244 WSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHIS 303
WSLGV++YI+L G+PPF + G + + I+ G+Y FP+ +W+ +S
Sbjct: 226 WSLGVIMYILLCGFPPFYSNTG-----------QAISPGMKRRIRLGQYGFPNPEWSEVS 274
Query: 304 SEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
+AK LI LL D +RL+ Q + HPW+
Sbjct: 275 EDAKQLIRLLLKTDPTERLTITQFMNHPWI 304
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 173 bits (439), Expect = 2e-43
Identities = 105/297 (35%), Positives = 161/297 (54%), Gaps = 30/297 (10%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ 102
+F ++Y+L ++ G G+Y+ + + E+AVKII+K S+ E+E L +
Sbjct: 421 QFGEVYELKEDI-GVGSYSVCKRCIHATTNMEFAVKIIDK----SKRDPSEEIEILMRYG 475
Query: 103 GNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLH 162
+ NI+ L + F+D YLV + ++GG +L I KQK F+EREAS ++ ++ +D+LH
Sbjct: 476 QHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLH 535
Query: 163 TKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
+G+ HRDLKP NIL + ++ICDF ++ N L TPC +A +
Sbjct: 536 CQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGL-------LLTPCYTANF 588
Query: 222 MAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQN 281
+APEV+ YD CD+WSLGV+ Y ML+GY PF A+ D E
Sbjct: 589 VAPEVL-----MQQGYDAACDIWSLGVLFYTMLAGYTPF-----ANGPNDTPE------- 631
Query: 282 KLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGEQQ 338
++ I GK+ +W +IS AKDL+S +L D QR +A Q+L+H W+ Q
Sbjct: 632 EILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWITHRDQ 688
Score = 108 bits (270), Expect = 7e-24
Identities = 84/291 (28%), Positives = 141/291 (48%), Gaps = 43/291 (14%)
Query: 41 PGKFEDMYKLTSELLGEGAYAKV---QGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVET 97
P +FE + ++LG+G++ KV + G+ YA+K+++K + R RV ++E
Sbjct: 70 PAQFELL-----KVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMER 124
Query: 98 LYQCQGNKNILELIEF-FEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAA 156
+ N + + + F+ + + YL+ + L+GG + + K+ F E + + ++A
Sbjct: 125 DILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELAL 184
Query: 157 ALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPC 216
ALD LH GI +RDLKPENIL +++ +K+ DF L + + + C
Sbjct: 185 ALDHLHQLGIVYRDLKPENILL---DEIGHIKLTDFGLSKE-------SVDQEKKAYSFC 234
Query: 217 GSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVC 276
G+ EYMAPEVV + + D WS GV+++ ML+G PF G DR
Sbjct: 235 GTVEYMAPEVV-----NRRGHSQSADWWSYGVLMFEMLTGTLPFQGK-------DR---- 278
Query: 277 RVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQV 327
N+ I + K P +S+EA+ L+ L R+ RL + V
Sbjct: 279 ----NETMNMILKAKLGMPQ----FLSAEAQSLLRMLFKRNPANRLGSEGV 321
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 171 bits (434), Expect = 7e-43
Identities = 101/298 (33%), Positives = 160/298 (53%), Gaps = 30/298 (10%)
Query: 40 LPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLY 99
+P + YK+ +G+G +A V+ V +EYA+KII+K + + + ++
Sbjct: 382 IPATITERYKV-GRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSIL 440
Query: 100 QCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
+ + NI+ LIE + T YLV E ++GG + I + ER+AS ++ ++A+A+
Sbjct: 441 RRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIK 500
Query: 160 FLHTKGIAHRDLKPENILC-ESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS 218
+LH+ I HRD+KPEN+L E + +K+ DF L + I L T CG+
Sbjct: 501 YLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLAT----------IVDGPLYTVCGT 550
Query: 219 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV 278
Y+APE++ T Y + D+W+ GV+ YI+L G+PPF G G D
Sbjct: 551 PTYVAPEII-----AETGYGLKVDIWAAGVITYILLCGFPPFRG-SGDD----------- 593
Query: 279 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGE 336
Q LF+ I G+ +FP W ++S AK+LI+ +L+ D QR SA QVL+HPWV +
Sbjct: 594 -QEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDD 650
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 171 bits (432), Expect = 1e-42
Identities = 108/313 (34%), Positives = 166/313 (53%), Gaps = 32/313 (10%)
Query: 31 KRRGRATDSLPGKFEDMYKLTS--ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSR 88
+ G ++ S + ED+ K+ E LG GA+++V A GK +AVK I K+A +
Sbjct: 3 RENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK 62
Query: 89 -SRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREA 147
S + E+ L + + ++NI+ L + +E YLV + + GG + I ++ + E++A
Sbjct: 63 ESSIENEIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDA 121
Query: 148 SRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPI 207
S ++R V A+ +LH GI HRDLKPEN+L S ++ S + I DF L S M+
Sbjct: 122 STLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGL-SKMEGKGDV--- 177
Query: 208 TTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD 267
++T CG+ Y+APEV+ Y K D WS+GV+ YI+L GYPPF
Sbjct: 178 ----MSTACGTPGYVAPEVL-----AQKPYSKAVDCWSIGVIAYILLCGYPPF------- 221
Query: 268 CGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQV 327
+D + +KLFE I + +YEF W IS AKD I L+ +D +R + Q
Sbjct: 222 --YDEND------SKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQA 273
Query: 328 LQHPWVQGEQQHN 340
+HPW+ G+ N
Sbjct: 274 ARHPWIAGDTALN 286
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 171 bits (432), Expect = 1e-42
Identities = 108/313 (34%), Positives = 166/313 (53%), Gaps = 32/313 (10%)
Query: 31 KRRGRATDSLPGKFEDMYKLTS--ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSR 88
+ G ++ S + ED+ K+ E LG GA+++V A GK +AVK I K+A +
Sbjct: 3 RENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGK 62
Query: 89 -SRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREA 147
S + E+ L + + ++NI+ L + +E YLV + + GG + I ++ + E++A
Sbjct: 63 ESSIENEIAVLRKIK-HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDA 121
Query: 148 SRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPI 207
S ++R V A+ +LH GI HRDLKPEN+L S ++ S + I DF L S M+
Sbjct: 122 STLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGL-SKMEGKGDV--- 177
Query: 208 TTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD 267
++T CG+ Y+APEV+ Y K D WS+GV+ YI+L GYPPF
Sbjct: 178 ----MSTACGTPGYVAPEVL-----AQKPYSKAVDCWSIGVIAYILLCGYPPF------- 221
Query: 268 CGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQV 327
+D + +KLFE I + +YEF W IS AKD I L+ +D +R + Q
Sbjct: 222 --YDEND------SKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQA 273
Query: 328 LQHPWVQGEQQHN 340
+HPW+ G+ N
Sbjct: 274 ARHPWIAGDTALN 286
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 171 bits (432), Expect = 1e-42
Identities = 114/363 (31%), Positives = 180/363 (49%), Gaps = 55/363 (15%)
Query: 4 SQKLEKPIEMGSSEPLPIADGDRRRKK-KRRGRATDSLPGKFE----------------- 45
S +L P SS P + G R K GR++ ++ G E
Sbjct: 326 SSQLSTPKSTKSSSSSPTSPGSFRGLKISAHGRSSSNVNGGPELDRCISPEGVNGNRCSE 385
Query: 46 -----DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQ 100
+ YK+ +++G+G +A V+ + GKE+A+KII+K + + ++ +
Sbjct: 386 SSTLLEKYKI-GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILR 444
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L+E E T +LV E ++GG + I + ER+ S +V ++A AL +
Sbjct: 445 RVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRY 504
Query: 161 LHTKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219
LH I HRD+KPEN+L CE P+ +K+ DF L + + L T CG+
Sbjct: 505 LHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLAT----------VVEGPLYTVCGTP 554
Query: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279
Y+APE++ T Y + D+W+ GV+ YI+L G+PPF R E
Sbjct: 555 TYVAPEII-----AETGYGLKVDIWAAGVITYILLCGFPPF-----------RSE--NNL 596
Query: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGE--Q 337
Q LF+ I GK EFP W +I+ AK+LIS++L + + R +A Q+L HPWV + Q
Sbjct: 597 QEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDASQ 656
Query: 338 QHN 340
++N
Sbjct: 657 ENN 659
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 171 bits (432), Expect = 1e-42
Identities = 114/364 (31%), Positives = 181/364 (49%), Gaps = 56/364 (15%)
Query: 4 SQKLEKPIEMGSSEPLPIADGDRRRKKK--RRGRATDSLPGKFE---------------- 45
S +L P SS P + G R K+ GR++ ++ G E
Sbjct: 326 SSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNVNGGPELDRCISPEGVNGNRCS 385
Query: 46 ------DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLY 99
+ YK+ +++G+G +A V+ + GKE+A+KII+K + + ++
Sbjct: 386 ESSTLLEKYKI-GKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSIL 444
Query: 100 QCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 159
+ + NI+ L+E E T +LV E ++GG + I + ER+ S +V ++A AL
Sbjct: 445 RRVKHPNIIMLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALR 504
Query: 160 FLHTKGIAHRDLKPENIL-CESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS 218
+LH I HRD+KPEN+L CE P+ +K+ DF L + + L T CG+
Sbjct: 505 YLHGLSIVHRDIKPENLLVCEYPDGTKSLKLGDFGLAT----------VVEGPLYTVCGT 554
Query: 219 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRV 278
Y+APE++ T Y + D+W+ GV+ YI+L G+PPF R E
Sbjct: 555 PTYVAPEII-----AETGYGLKVDIWAAGVITYILLCGFPPF-----------RSE--NN 596
Query: 279 CQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGE-- 336
Q LF+ I GK EFP W +I+ AK+LIS++L + + R +A Q+L HPWV +
Sbjct: 597 LQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQILSHPWVSDDAS 656
Query: 337 QQHN 340
Q++N
Sbjct: 657 QENN 660
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 168 bits (426), Expect = 6e-42
Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 31/293 (10%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ + +++
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126
Query: 161 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 220
H GI HRDLKPEN+L S K + VK+ DF L ++ + G+
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA-------WFGFAGTPG 179
Query: 221 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 280
Y++PEV+ + Y K D+W+ GV+LYI+L GYPPF WD Q
Sbjct: 180 YLSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------Q 219
Query: 281 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
++L++ I+ G Y+FP +W ++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 220 HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 168 bits (426), Expect = 6e-42
Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 31/293 (10%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ + +++
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126
Query: 161 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 220
H GI HRDLKPEN+L S K + VK+ DF L ++ + G+
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA-------WFGFAGTPG 179
Query: 221 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 280
Y++PEV+ + Y K D+W+ GV+LYI+L GYPPF WD Q
Sbjct: 180 YLSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------Q 219
Query: 281 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
++L++ I+ G Y+FP +W ++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 220 HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 168 bits (426), Expect = 6e-42
Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 31/293 (10%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ + +++
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126
Query: 161 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 220
H GI HRDLKPEN+L S K + VK+ DF L ++ + G+
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA-------WFGFAGTPG 179
Query: 221 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 280
Y++PEV+ + Y K D+W+ GV+LYI+L GYPPF WD Q
Sbjct: 180 YLSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------Q 219
Query: 281 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
++L++ I+ G Y+FP +W ++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 220 HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 168 bits (426), Expect = 6e-42
Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 31/293 (10%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ + +++
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126
Query: 161 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 220
H GI HRDLKPEN+L S K + VK+ DF L ++ + G+
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA-------WFGFAGTPG 179
Query: 221 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 280
Y++PEV+ + Y K D+W+ GV+LYI+L GYPPF WD Q
Sbjct: 180 YLSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------Q 219
Query: 281 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
++L++ I+ G Y+FP +W ++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 220 HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 168 bits (426), Expect = 6e-42
Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 31/293 (10%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ + +++
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126
Query: 161 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 220
H GI HRDLKPEN+L S K + VK+ DF L ++ + G+
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA-------WFGFAGTPG 179
Query: 221 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 280
Y++PEV+ + Y K D+W+ GV+LYI+L GYPPF WD Q
Sbjct: 180 YLSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------Q 219
Query: 281 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
++L++ I+ G Y+FP +W ++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 220 HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 168 bits (426), Expect = 6e-42
Identities = 96/293 (32%), Positives = 165/293 (56%), Gaps = 31/293 (10%)
Query: 43 KFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKII--EKQAGHSRSRVFREVETLYQ 100
+F D Y+L EL G+GA++ V+ + + G+EYA KII +K + ++ RE + +
Sbjct: 9 RFTDEYQLFEEL-GKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREAR-ICR 66
Query: 101 CQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDF 160
+ NI+ L + ++ YLVF+ + GG + I +++++E +AS ++ + +++
Sbjct: 67 LLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNH 126
Query: 161 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 220
H GI HRDLKPEN+L S K + VK+ DF L ++ + G+
Sbjct: 127 CHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQA-------WFGFAGTPG 179
Query: 221 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQ 280
Y++PEV+ + Y K D+W+ GV+LYI+L GYPPF WD Q
Sbjct: 180 YLSPEVL-----RKDPYGKPVDMWACGVILYILLVGYPPF---------WDED------Q 219
Query: 281 NKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
++L++ I+ G Y+FP +W ++ EAKDLI+K+L + +R++A++ L+HPW+
Sbjct: 220 HRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWI 272
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 168 bits (426), Expect = 6e-42
Identities = 110/330 (33%), Positives = 169/330 (51%), Gaps = 36/330 (10%)
Query: 6 KLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQG 65
KLEK + E P R R+ R + E Y+ T ++G+G +A V+
Sbjct: 320 KLEKEPKTRPEENKP------ERPSGRKPRPMGIIAANVEKHYE-TGRVIGDGNFAVVKE 372
Query: 66 AVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFE 125
+ + YA+KII+K + + + Q + NI++L E +E D YL+ E
Sbjct: 373 CRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLSHPNIVKLHEVYETDMEIYLILE 432
Query: 126 KLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCE-SPEKV 184
+QGG + I + F E +A+ ++ D+ AL +H K I HRDLKPEN+L + + +K
Sbjct: 433 YVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKS 492
Query: 185 SPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLW 244
+ +K+ DF L + + T CG+ Y+APE++ Y D+W
Sbjct: 493 TTLKLADFGLAKHV----------VRPIFTVCGTPTYVAPEIL-----SEKGYGLEVDMW 537
Query: 245 SLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISS 304
+ GV+LYI+L G+PPF +R Q++LF IQ G +EF W +IS
Sbjct: 538 AAGVILYILLCGFPPFRSP-------ERD------QDELFNIIQLGHFEFLPPYWDNISD 584
Query: 305 EAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 334
AKDL+S+LLV D K+R +A QVLQHPW++
Sbjct: 585 AAKDLVSRLLVVDPKKRYTAHQVLQHPWIE 614
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 168 bits (426), Expect = 6e-42
Identities = 108/324 (33%), Positives = 160/324 (49%), Gaps = 33/324 (10%)
Query: 10 PIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSL 69
P G +EP P R R K R + + K++ L+G G++++V
Sbjct: 65 PPTAGHTEP-PSEPPRRARVAKYRAKFDPRVTAKYD-----IKALIGRGSFSRVVRVEHR 118
Query: 70 QNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQG 129
+ YA+K+IE + R E+ L + + + NI++L+E FE R Y+V E G
Sbjct: 119 ATRQPYAIKMIETKYREGREVCESELRVLRRVR-HANIIQLVEVFETQERVYMVMELATG 177
Query: 130 GSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKI 189
G + I + F ER+A+RV++ V + +LH GI HRDLKPEN+L P S + I
Sbjct: 178 GELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIII 237
Query: 190 CDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVV 249
DF L S K + C + T CG+ EY+APEV+ Y D+W+LGV+
Sbjct: 238 TDFGLASARKKGDDCL------MKTTCGTPEYIAPEVL-----VRKPYTNSVDMWALGVI 286
Query: 250 LYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDL 309
YI+LSG PF + +L+ I GKY + + W +S+ AKD
Sbjct: 287 AYILLSGTMPFEDD---------------NRTRLYRQILRGKYSYSGEPWPSVSNLAKDF 331
Query: 310 ISKLLVRDAKQRLSAAQVLQHPWV 333
I +LL D R++A Q L+HPWV
Sbjct: 332 IDRLLTVDPGARMTALQALRHPWV 355
>gi|32481209 mitogen-activated protein kinase-activated protein
kinase 2 isoform 2 [Homo sapiens]
Length = 400
Score = 166 bits (421), Expect = 2e-41
Identities = 98/294 (33%), Positives = 159/294 (54%), Gaps = 35/294 (11%)
Query: 46 DMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNK 105
D YK+TS++LG G KV + + +++A+K+++ + REVE ++
Sbjct: 61 DDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----DCPKARREVELHWRASQCP 115
Query: 106 NILELIEFFED----DTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALD 159
+I+ +++ +E+ +V E L GG + + IQ + + F EREAS +++ + A+
Sbjct: 116 HIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175
Query: 160 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 219
+LH+ IAHRD+KPEN+L S + +K+ DF +NS LTTPC +
Sbjct: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNS--------LTTPCYTP 227
Query: 220 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVC 279
Y+APEV+ YDK CD+WSLGV++YI+L GYPPF + G
Sbjct: 228 YYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGL-----------AI 271
Query: 280 QNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
+ I+ G+YEFP+ +W+ +S E K LI LL + QR++ + + HPW+
Sbjct: 272 SPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,995,669
Number of Sequences: 37866
Number of extensions: 631770
Number of successful extensions: 3808
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 557
Number of HSP's successfully gapped in prelim test: 208
Number of HSP's that attempted gapping in prelim test: 1642
Number of HSP's gapped (non-prelim): 952
length of query: 347
length of database: 18,247,518
effective HSP length: 103
effective length of query: 244
effective length of database: 14,347,320
effective search space: 3500746080
effective search space used: 3500746080
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.