Search of human proteins with 39725717

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|39725717 coiled-coil domain containing 141 [Homo sapiens]
         (875 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|39725717 coiled-coil domain containing 141 [Homo sapiens]         1742   0.0  
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       76   2e-13
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    67   6e-11
gi|118498356 kinectin 1 isoform a [Homo sapiens]                       63   1e-09
gi|33620775 kinectin 1 isoform a [Homo sapiens]                        63   1e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             60   9e-09
gi|71061468 centromere protein E [Homo sapiens]                        60   1e-08
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     59   2e-08
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    59   2e-08
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    59   2e-08
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    59   2e-08
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    59   2e-08
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    59   2e-08
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    59   3e-08
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  59   3e-08
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    58   4e-08
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]                    56   1e-07
gi|221219020 NYD-SP11 protein [Homo sapiens]                           56   2e-07
gi|118498368 kinectin 1 isoform c [Homo sapiens]                       56   2e-07
gi|118498362 kinectin 1 isoform b [Homo sapiens]                       55   2e-07
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]                     55   2e-07
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]                     55   2e-07
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    55   2e-07
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    55   2e-07
gi|38044112 restin isoform b [Homo sapiens]                            55   3e-07
gi|4506751 restin isoform a [Homo sapiens]                             55   3e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    55   3e-07
gi|221316624 dystonin isoform 4 [Homo sapiens]                         55   4e-07
gi|221316622 dystonin isoform 3 [Homo sapiens]                         55   4e-07
gi|221316618 dystonin isoform 2 [Homo sapiens]                         55   4e-07

>gi|39725717 coiled-coil domain containing 141 [Homo sapiens]
          Length = 875

 Score = 1742 bits (4511), Expect = 0.0
 Identities = 875/875 (100%), Positives = 875/875 (100%)

Query: 1   MQFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAK 60
           MQFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAK
Sbjct: 1   MQFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAK 60

Query: 61  ENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTS 120
           ENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTS
Sbjct: 61  ENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTS 120

Query: 121 HNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRG 180
           HNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRG
Sbjct: 121 HNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRG 180

Query: 181 APVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPK 240
           APVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPK
Sbjct: 181 APVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPK 240

Query: 241 ELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELL 300
           ELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELL
Sbjct: 241 ELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELL 300

Query: 301 EEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSR 360
           EEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSR
Sbjct: 301 EEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSR 360

Query: 361 NLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVD 420
           NLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVD
Sbjct: 361 NLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVD 420

Query: 421 DFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQF 480
           DFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQF
Sbjct: 421 DFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQF 480

Query: 481 NKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELE 540
           NKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELE
Sbjct: 481 NKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELE 540

Query: 541 EKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGTGEE 600
           EKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGTGEE
Sbjct: 541 EKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGTGEE 600

Query: 601 RLPQDLKVSTDKEGGVQDLLLPEDMLSGEEYECVSPDDISLPPLPGSPESPLAPSDMEVE 660
           RLPQDLKVSTDKEGGVQDLLLPEDMLSGEEYECVSPDDISLPPLPGSPESPLAPSDMEVE
Sbjct: 601 RLPQDLKVSTDKEGGVQDLLLPEDMLSGEEYECVSPDDISLPPLPGSPESPLAPSDMEVE 660

Query: 661 EPVSSSLSLHISSYGVQAGTSSPGDAQESVLPPPVAFADACNDKRETFSSHFERPYLQFK 720
           EPVSSSLSLHISSYGVQAGTSSPGDAQESVLPPPVAFADACNDKRETFSSHFERPYLQFK
Sbjct: 661 EPVSSSLSLHISSYGVQAGTSSPGDAQESVLPPPVAFADACNDKRETFSSHFERPYLQFK 720

Query: 721 AEPPLTSRGFVEKSTALHRISAEHPESMMSEVHERALQQHPQAQGGLLETREKMHADNNF 780
           AEPPLTSRGFVEKSTALHRISAEHPESMMSEVHERALQQHPQAQGGLLETREKMHADNNF
Sbjct: 721 AEPPLTSRGFVEKSTALHRISAEHPESMMSEVHERALQQHPQAQGGLLETREKMHADNNF 780

Query: 781 TKTQDRLHASSDAFSGLRFQSGTSRGYQRQMVPREEIKSTSAKSSVVSLADQAPNFSRLL 840
           TKTQDRLHASSDAFSGLRFQSGTSRGYQRQMVPREEIKSTSAKSSVVSLADQAPNFSRLL
Sbjct: 781 TKTQDRLHASSDAFSGLRFQSGTSRGYQRQMVPREEIKSTSAKSSVVSLADQAPNFSRLL 840

Query: 841 SNVTVMEGSPVTLEVEVTGFPEPTLTWWVAYNDKP 875
           SNVTVMEGSPVTLEVEVTGFPEPTLTWWVAYNDKP
Sbjct: 841 SNVTVMEGSPVTLEVEVTGFPEPTLTWWVAYNDKP 875


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 132/606 (21%), Positives = 260/606 (42%), Gaps = 88/606 (14%)

Query: 16   QKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMK 75
            +K+ DD +        EK       K+   +  GL+ + +  + KE + L   ++  L  
Sbjct: 953  KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI-IAKLTKEKKALQEAHQQALDD 1011

Query: 76   NTMENQKAEREELSLLRLAWQLKATES--KPGKQQWAAFKEQLKKTSHNLKLLQEALMPV 133
              +E  K      S ++L  Q+   E   +  K+     +   +K   +LKL QE++M +
Sbjct: 1012 LQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1071

Query: 134  SALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDL 193
                    LQ    L++K  D+  Q  ++ DE    ++  ++L    A ++E  ++L + 
Sbjct: 1072 E----NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEEL-EA 1126

Query: 194  IHFHQKQKERIQDYEDILYKVVQFHQVKEELG-------RLIKSRELEFVEQPKELGDA- 245
                + + E+++   D+  ++ +  +  EE G        + K RE EF +  ++L +A 
Sbjct: 1127 ERTARAKVEKLRS--DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT 1184

Query: 246  --HDVQI------HLRCSQEKQARVDHLHRLALSLGV----------DIISSVQRPHCSN 287
              H+         H     E   ++D+L R+   L            D+ S++++     
Sbjct: 1185 LQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI---- 1240

Query: 288  VSAK-NLQQQLELLEEDSMKWRAKAEEYGRTLSR-SVEYCAMRDEINELKDSFKDIKKKF 345
            + AK NL++    LE+ + ++R K EE  R+L+  + +   ++ E  EL    ++ +   
Sbjct: 1241 IKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALI 1300

Query: 346  NNL---KFNYTKK--------NEKSRNLKALKYQIQQV--------DMYAEKMQA---LK 383
            + L   K +YT++         E+ +   AL + +Q          + Y E+ +A   L+
Sbjct: 1301 SQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQ 1360

Query: 384  RKMEKVSNKTSDSFLNYPSDKVN---VLLEVMKDLQKHVDDFDKVVTDYK---KNLDLTE 437
            R + K +++ +     Y +D +     L E  K L + + D ++ V        +L+ T+
Sbjct: 1361 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK 1420

Query: 438  H-FQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQ 496
            H  Q  IE+     E ++A    + K     K +   KIL +   K+   S  + E   +
Sbjct: 1421 HRLQNEIEDLMVDVERSNAAAAALDK-----KQRNFDKILAEWKQKY-EESQSELESSQK 1474

Query: 497  EATDLAQHLYGL----EEGQKYIEKIVTKHKEVLESVTELCESL-------TELEEKLKQ 545
            EA  L+  L+ L    EE  +++E    ++K + E +++L E L        ELE+  KQ
Sbjct: 1475 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQ 1534

Query: 546  GDVLKM 551
             +V K+
Sbjct: 1535 LEVEKL 1540



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 103/535 (19%), Positives = 216/535 (40%), Gaps = 97/535 (18%)

Query: 61   ENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTS 120
            E E+  +K E   +K T+E  +A R+EL    ++            Q+    + Q++   
Sbjct: 848  EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSL----------LQEKNDLQLQVQAEQ 897

Query: 121  HNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRG 180
             NL   +E              Q I +  Q    +K   ++L DE +     + ELT + 
Sbjct: 898  DNLNDAEERCD-----------QLIKNKIQLEAKVKEMNERLEDEEEM----NAELTAKK 942

Query: 181  APVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPK 240
              ++++  +LK             +D +D+   + +  + K      +K+   E      
Sbjct: 943  RKLEDECSELK-------------KDIDDLELTLAKVEKEKHATENKVKNLTEEM----- 984

Query: 241  ELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELL 300
                A   +I  + ++EK+A +   H+ AL    D+     + +  + S   L+QQ++ L
Sbjct: 985  ----AGLDEIIAKLTKEKKA-LQEAHQQALD---DLQVEEDKVNSLSKSKVKLEQQVDDL 1036

Query: 301  E---EDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNE 357
            E   E   K R   E   R L   ++    ++ I +L++    +++K    +F+  ++N 
Sbjct: 1037 EGSLEQEKKVRMDLERAKRKLEGDLK--LTQESIMDLENDKLQLEEKLKKKEFDINQQNS 1094

Query: 358  KSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQK 417
            K  + + L  Q+Q      +K++  + ++E++  +                LE  +  + 
Sbjct: 1095 KIEDEQVLALQLQ------KKLKENQARIEELEEE----------------LEAERTARA 1132

Query: 418  HVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVG-KYSTECKTKEAVKIL 476
             V+         K   DL+   +E+ E      E   AT V++      E + ++  + L
Sbjct: 1133 KVE---------KLRSDLSRELEEISERLE---EAGGATSVQIEMNKKREAEFQKMRRDL 1180

Query: 477  HQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESL 536
             +   +  A +   +++      +L + +  L+  ++ +EK  ++ K  L+ VT   E +
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1240

Query: 537  TELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADL 591
             + +  L+     K++  LED   +Y   L+E A+     F  +R K Q +  +L
Sbjct: 1241 IKAKANLE-----KVSRTLEDQANEYRVKLEE-AQRSLNDFTTQRAKLQTENGEL 1289



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 107/529 (20%), Positives = 204/529 (38%), Gaps = 75/529 (14%)

Query: 107  QQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEV 166
            Q+    +E  KK +  L+  +EA+  V+A               K + ++    +L +E+
Sbjct: 1383 QRTEELEEAKKKLAQRLQDAEEAVEAVNA---------------KCSSLEKTKHRLQNEI 1427

Query: 167  QYIMKESEELTGRGAPVKEKSQQL-KDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELG 225
            + +M + E      A + +K +   K L  + QK +E   + E       +   +  EL 
Sbjct: 1428 EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELES---SQKEARSLSTELF 1484

Query: 226  RLIKSRE--LEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRP 283
            +L  + E  LE +E  K               +E +   + +  L   LG          
Sbjct: 1485 KLKNAYEESLEHLETFK---------------RENKNLQEEISDLTEQLGEG------GK 1523

Query: 284  HCSNVSAKNLQQQLELLEEDSMKWRAKAE---EYGRTLSRSVEYCAMRDEINELKDSFKD 340
            +   +     Q ++E LE  S    A+A    E G+ L   +E+  ++ EI E K + KD
Sbjct: 1524 NVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI-ERKLAEKD 1582

Query: 341  IKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKT------S 394
             + +          K    R + +L+  +        ++  +K+KME   N+       +
Sbjct: 1583 EEME--------QAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHA 1634

Query: 395  DSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEH----FQEVIEECHFWY 450
            +        +V  L  ++KD Q  +DD  +   D K+N+ + E      Q  +EE     
Sbjct: 1635 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVV 1694

Query: 451  EDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEE 510
            E    +  R        +T E V++LH Q    I      Q+++++  +DL Q    +EE
Sbjct: 1695 EQTERS--RKLAEQELIETSERVQLLHSQNTSLI-----NQKKKME--SDLTQLQSEVEE 1745

Query: 511  GQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPA 570
              +       K K+ +     + E L   +E+     + +M  N+E    D    L E  
Sbjct: 1746 AVQECRNAEEKAKKAITDAAMMAEELK--KEQDTSAHLERMKKNMEQTIKDLQHRLDEAE 1803

Query: 571  KNKQTIFNEERNKGQVQVADLLGINGTGEERLPQDLKVSTDKEGGVQDL 619
            +       ++  K + +V +L G     ++R  + +K     E  +++L
Sbjct: 1804 QIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKEL 1852


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 111/557 (19%), Positives = 228/557 (40%), Gaps = 100/557 (17%)

Query: 75   KNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVS 134
            K  ++  K+ +EELSL R   +         + Q +A  ++       L LLQE    + 
Sbjct: 1493 KEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI 1552

Query: 135  ALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLI 194
              ++  SL     L      +K   + L ++ + ++KE E L         KS ++ +  
Sbjct: 1553 T-EMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL---------KSSKIAEST 1602

Query: 195  HFHQKQKERIQDYEDIL--------------YKVVQFHQVKEELGRLIKSRELEFVEQPK 240
             + +K KE  ++YE +L              + V    Q K+EL   ++S E    E  K
Sbjct: 1603 EWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEK 1662

Query: 241  ELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELL 300
            +L +A          QE +   + + + A                     K+ QQ++  L
Sbjct: 1663 QLQEAE---------QEMEEMKEKMRKFA---------------------KSKQQKILEL 1692

Query: 301  EEDSMKWRAKAEEYGRTLSRSVE-----YCAMRDEINELKDSFKDIKKKFNNLKFNYTKK 355
            EE++ + RA+    G T    +E       +M++E+  +K  ++ + KKF +L    ++K
Sbjct: 1693 EEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSL---MSEK 1749

Query: 356  NEKSRNLKALKYQIQ-----------------QVDMYAEKMQALKRKMEK---VSNKTSD 395
            +  S  ++ LK+QI+                 Q ++  E  Q++  + E+   +S  T  
Sbjct: 1750 DSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRP 1809

Query: 396  SFLNYPSDKVNVLLEVMKDLQKH--VDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDA 453
            +         +    V KD   H  ++++ + +   K+ +   E  ++  +E     E+ 
Sbjct: 1810 TCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENE 1869

Query: 454  SATVVRVGKYSTECKTKEA-VKILHQQFNKFIAPSVPQQEE--RIQEATDLAQHLYGLEE 510
              T++      ++  TK+  +K+L ++  K    +   QEE  R+ +  + A+     EE
Sbjct: 1870 KNTLL------SQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE-----EE 1918

Query: 511  GQKYIEKIVTKHKEVLESVTELCESLT--ELEEKLKQGDVLKMNPNLEDFHYDYIDLLKE 568
                 E+++ +  E+  S+   C+ +T  +++ +L + ++  +   + +   +   L+KE
Sbjct: 1919 KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKE 1978

Query: 569  PAKNKQTIFNEERNKGQ 585
              K +  I  E   K Q
Sbjct: 1979 KTKVESEIRKEYLEKIQ 1995



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 132/666 (19%), Positives = 279/666 (41%), Gaps = 118/666 (17%)

Query: 2    QFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFL-------N 54
            Q   LKE     I   E++  K K  S + E +    L +   T+D  L+ L       N
Sbjct: 1841 QIDQLKE----RIAGLEEEKQKNKEFSQTLENEKNTLLSQ-ISTKDGELKMLQEEVTKMN 1895

Query: 55   LINMAKENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKE 114
            L+N   + E+    + V  +K T E +K + EE    RL  QL       G         
Sbjct: 1896 LLNQQIQEEL----SRVTKLKETAEEEKDDLEE----RLMNQLAELNGSIGNYCQDVTDA 1947

Query: 115  QLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESE 174
            Q+K      +LL+  +  +         + + +L ++   +  +  ++  E++    E  
Sbjct: 1948 QIKN-----ELLESEMKNLK--------KCVSELEEEKQQLVKEKTKVESEIRKEYLEKI 1994

Query: 175  ELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELE 234
            +   +    K  +++L++L+      KE+ Q+ + +    +++ +    L R +K+  LE
Sbjct: 1995 QGAQKEPGNKSHAKELQELL------KEKQQEVKQLQKDCIRYQEKISALERTVKA--LE 2046

Query: 235  FVEQPKELGDAHDVQIHLRCSQEKQAR-VDHLHRLALSL-GVDIISSVQRPHCSNVSAKN 292
            FV+         + Q  L  ++E  A+ V+H  +    L    ++    +   + V A N
Sbjct: 2047 FVQT--------ESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADN 2098

Query: 293  LQQQLEL---LEEDSMKWRAKAEEYGRTLSRSVEYCA-----MRDEINELKDSFKDIKKK 344
            L+ + EL    E    + + K E+  R L ++ E        M+++++ L+     +++ 
Sbjct: 2099 LKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEET 2158

Query: 345  FNNLKFNYTKKNEKSRNLKA-LKYQIQQVDMYAEKMQALKRKMEKV-------SNKTSDS 396
               ++    KK+++ + L+  L   + Q+  + + M +L+   ++V         K SD+
Sbjct: 2159 IGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDA 2218

Query: 397  F------LNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWY 450
                   +    D  +VL + ++ +  H+++        K N+   EH +++ E      
Sbjct: 2219 IQSKEEEIRLKEDNCSVLKDQLRQMSIHMEEL-------KINISRLEHDKQIWE------ 2265

Query: 451  EDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEE 510
                       K  TE + ++ V    Q  NK +   + Q EE         +HLY    
Sbjct: 2266 ----------SKAQTEVQLQQKVCDTLQGENKEL---LSQLEE--------TRHLY--HS 2302

Query: 511  GQKYIEKIVTKHKEVLESVTELCESLTELEEKL--KQGDVLKMNPNLED--FHYDYIDLL 566
             Q  + K+ ++ K + + +T+L  SL + +E+    +G + +   ++++  F Y+ ++  
Sbjct: 2303 SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETD 2362

Query: 567  KEPAKNKQTIFNEERNKGQVQVADLLGINGTGEERLPQDLKVSTDKEGGVQDLLLPEDML 626
             + ++   +  +EE N  + ++  LL       +    +L+   DKE  +++L   E++L
Sbjct: 2363 LQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKE--IKEL---ENLL 2417

Query: 627  SGEEYE 632
            S EE E
Sbjct: 2418 SQEEEE 2423



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 100/523 (19%), Positives = 218/523 (41%), Gaps = 58/523 (11%)

Query: 60   KENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKT 119
            KE E   V+ E+ +   T E  K   E        +QL+   +K G +      E LK  
Sbjct: 1312 KEIEAEKVELELKVSSTTSELTKKSEE-------VFQLQEQINKQGLEI-----ESLKTV 1359

Query: 120  SHNLKLLQEAL---MPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEEL 176
            SH  ++  E+L   +  S L + G L+ + +L+ K ++++    +  ++V Y+  +  E 
Sbjct: 1360 SHEAEVHAESLQQKLESSQLQIAG-LEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEK 1418

Query: 177  TGRGAPVKEKSQQLKDLI-----HFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSR 231
                  ++ +  + +DLI         + KE  +  + +  ++ +  Q  EE+G   +++
Sbjct: 1419 EAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAK 1478

Query: 232  -ELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSA 290
             +++   Q   +     ++ +    +E       + RL  SL  D+ S V      N   
Sbjct: 1479 QQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSL-ADVESQVS---AQNKEK 1534

Query: 291  KNLQQQLELLEEDSMKWRAKAEE---YGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNN 347
              +  +L LL+E+  K   + +      ++LS S E  +++  +  L +  + + K+  +
Sbjct: 1535 DTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCE--SLKLALEGLTEDKEKLVKEIES 1592

Query: 348  LKFN----YTKKNEKSRNL-KALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPS 402
            LK +     T+  EK + L K  +  +Q  +  + + + ++  +E V  +  + +    S
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652

Query: 403  DKVNVLLEVMKDLQKHVDDFDKVVTDYKKNL-DLTEHFQEVIEECHFWYEDASATVVRVG 461
             + N      K+ +K + + ++ + + K+ +    +  Q+ I E     +   A V   G
Sbjct: 1653 TEAN-----KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAG 1707

Query: 462  KYSTEC------------KTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLE 509
              + EC            +  E VK+ ++  +K     + +++   +E  DL   + G  
Sbjct: 1708 DTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNV 1767

Query: 510  EGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMN 552
              Q  +E   T+  +   +VTE  E    +  + ++ D L M+
Sbjct: 1768 SKQANLE--ATEKHDNQTNVTE--EGTQSIPGETEEQDSLSMS 1806



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 179/961 (18%), Positives = 345/961 (35%), Gaps = 176/961 (18%)

Query: 2    QFQSLKEFYETEIPQKEQD------DAKAKHCSDSAEKQWQLFL---KKSFITQDLGLEF 52
            + QS KE  ++++ QK++D       A+ KH  +    Q +L     +K  + + +G   
Sbjct: 2104 ELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQ 2163

Query: 53   LNLINMAKE----NEILD-VKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQ 107
            + L    KE     E LD    ++     +M + + +R+ +      W+ K +++   K+
Sbjct: 2164 VTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKE 2223

Query: 108  QWAAFKEQ----LKKTSHNLKL-LQEALMPVSALDLGGSL-----QFILDLRQKWNDM-- 155
            +    KE     LK     + + ++E  + +S L+    +     Q  + L+QK  D   
Sbjct: 2224 EEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQ 2283

Query: 156  ---KPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYE---- 208
               K    QL +          EL    + +K    QL DL +  +K KE+  + E    
Sbjct: 2284 GENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIR 2343

Query: 209  ----DILYKVVQFHQVKEEL--GRLIKSRELEFVEQPKEL------GDAHDVQIHL-RCS 255
                DI      + Q++ +L   R + SR  E +   ++       G    +Q+ +    
Sbjct: 2344 QQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELR 2403

Query: 256  QEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYG 315
            Q+    +  L  L      + I   +    +      L + L+ +++++++ +A+ + + 
Sbjct: 2404 QQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFV 2463

Query: 316  RTLS------------------RSVEYCAMRDEI--------NELKDSFKDIKKKFNNLK 349
            +++S                  R +     +D++        N+LK+  + ++   ++L 
Sbjct: 2464 KSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLN 2523

Query: 350  FNYTKKNEK----------------SRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKT 393
                K + +                S+  + L+ Q+QQ      K   L+ K+++     
Sbjct: 2524 SENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEAN 2583

Query: 394  SDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTE--------HFQEVI-- 443
             D   ++     N L E  +DL K ++     ++   + +   +        H Q  +  
Sbjct: 2584 EDLRRSF-----NALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKE 2638

Query: 444  EECHFWYEDASATVVRVGKYSTE--CKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDL 501
            EE H      S++  R+ +   E  C  KEA K             V + E+++++    
Sbjct: 2639 EEVHRLSALFSSSQKRIAELEEELVCVQKEAAK------------KVGEIEDKLKKELKH 2686

Query: 502  AQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKL------------------ 543
              H  G+   +       T+  E  E V EL   L E+E+KL                  
Sbjct: 2687 LHHDAGIMRNE-------TETAE--ERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFG 2737

Query: 544  -----KQGDVLKMNPNLEDFHYDYIDLLKEPAKNK-QTIFNEERNKGQVQVADLLGINGT 597
                  Q      N  L++    Y   LKE A+ K Q + N ER+    + A    +N T
Sbjct: 2738 RSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA--FSMNST 2795

Query: 598  GEERLPQDLKVSTDKEGGVQDLLLPEDMLSGEEYECVSPDDISLPPLPGSPESPLAPSDM 657
             E  L    K++       + LL     L  + Y  V            S    +A    
Sbjct: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLE-DSYNQVQ-----------SFSKAMASLQN 2843

Query: 658  EVEEPVSSSLSLHISSYGVQAGTSSPGDAQESVLPPPVAFADACNDKRETFS--SHFERP 715
            E +   +       S  G Q   + P  +   V     A +   ND+        + ++ 
Sbjct: 2844 ERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQ 2903

Query: 716  YLQFKAE----PPLTS--RGFVEKSTALHRISAEHPESMMSEVHERALQQHPQAQGGLLE 769
            YLQ   E     PL +  + + +K+ A   +  E  +  +S  HE    +  ++   + E
Sbjct: 2904 YLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHE 2963

Query: 770  TREKMHADNNFTKTQDRLHASSDAFSGLRFQSGTSR----GYQRQMVPREEIKSTSAKSS 825
             R K       +    +L    +    LR  S  ++     YQRQ  P        +++ 
Sbjct: 2964 RRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNL 3023

Query: 826  V 826
            V
Sbjct: 3024 V 3024



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 102/548 (18%), Positives = 233/548 (42%), Gaps = 91/548 (16%)

Query: 31   AEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKNTMENQKAEREELSL 90
            AE+Q +L  +      +L  E ++ +++  +++  DVK EV  ++N +++ + +  E S 
Sbjct: 776  AERQRRLDYESQTAHDNLLTEQIHSLSIEAKSK--DVKIEV--LQNELDDVQLQFSEQST 831

Query: 91   LRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQ 150
            L  + Q +    +    + A   E+++  S  ++ L +AL     L++    Q +L+ ++
Sbjct: 832  LIRSLQSQLQNKESEVLEGA---ERVRHISSKVEELSQALSQ-KELEITKMDQLLLEKKR 887

Query: 151  KWNDMKPQFQQLND---EVQYIMKE-----SEELTGRGAPVKEKSQQLKDLIHFHQKQKE 202
                ++   ++ +    E+ + M E     +EE    G  +K   +QL  L    + +KE
Sbjct: 888  DVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKE 947

Query: 203  RIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARV 262
            ++++  ++   + Q +      G++ K  EL+           H+  +  + +++++ ++
Sbjct: 948  QVEEDNEVSSGLKQNYDEMSPAGQISK-EELQ-----------HEFDLLKKENEQRKRKL 995

Query: 263  DHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSV 322
                + AL    +++  V R          L+++L  L+++S K    +E          
Sbjct: 996  ----QAALINRKELLQRVSR----------LEEELANLKDESKKEIPLSE---------- 1031

Query: 323  EYCAMRDEINELKD----SFKDIKKKFNNLKFNYTKK--NEKSRNLKALKYQIQQVDMYA 376
                 R E+ E K+    S K +  K   ++  Y K+  +EK   L+ ++  +++     
Sbjct: 1032 ---TERGEVEEDKENKEYSEKCVTSKCQEIEI-YLKQTISEKEVELQHIRKDLEEKLAAE 1087

Query: 377  EKMQALKRKM-EKVSNKTSD-SFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLD 434
            E+ QAL ++M + + +KT+    L     +   +++ +        D D V    K+ + 
Sbjct: 1088 EQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVAL-VKETVV 1146

Query: 435  L-------TEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPS 487
            +       +EH++  +EE     E     + +  K      +++A+    Q+  + +   
Sbjct: 1147 ISPPCTGSSEHWKPELEEKILALEKEKEQLQK--KLQEALTSRKAILKKAQEKERHLREE 1204

Query: 488  VPQQEE---RIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESV---------TELCES 535
            + QQ++   R+QE  D        +E +   +++     +V ES+          E C S
Sbjct: 1205 LKQQKDDYNRLQEQFDEQS-----KENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSS 1259

Query: 536  LTELEEKL 543
               LEE L
Sbjct: 1260 TPGLEEPL 1267



 Score = 30.8 bits (68), Expect = 5.7
 Identities = 65/283 (22%), Positives = 114/283 (40%), Gaps = 39/283 (13%)

Query: 508 LEEGQKYIEKIVTKHKEVL-ESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLL 566
           ++E   Y E++V + K+++ +   +L +    L+E+ K  D             + I  L
Sbjct: 50  VQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAAD-------------NKIKKL 96

Query: 567 KEPAKNKQTIFNEERNKGQVQVADLLGINGTGEERLPQDLKVSTDKEGGVQDLLLPEDML 626
           K  AK K T  N+   + + Q   +L      EE+L +  K ST++E  ++ +   +  L
Sbjct: 97  KLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKI---KHKL 153

Query: 627 SGEEYECVSPDDISLPPLPGSPESPLAPSDMEVEEPVSSSLSLH-----ISSYGVQAGTS 681
             E+ E +S     L       E P A S  E+EE V     L      IS+   Q   +
Sbjct: 154 Q-EKEELISTLQAQL--TQAQAEQP-AQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQT 209

Query: 682 SPGDAQESVLPPPVAFADACNDKRETFSSHFERPYLQFKAEPPLTSRGFVEKSTALHRIS 741
               A + V+    A       + ET     E   LQ   +  + +    +K   L R  
Sbjct: 210 QAEQAAQQVVREKDA-------RFETQVRLHEDELLQLVTQADVETE-MQQKLRVLQRKL 261

Query: 742 AEHPESMMS-----EVHERALQQHPQAQGGLLETREKMHADNN 779
            EH ES++      ++ ++ L    Q    L +  ++M A++N
Sbjct: 262 EEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHN 304


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 118/546 (21%), Positives = 225/546 (41%), Gaps = 73/546 (13%)

Query: 86   EELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHN----LKLLQEALMPVSALDLGGS 141
            E  SL +    LKA ++   +  +A+  E+LKK  H     +K ++E L+    L +   
Sbjct: 771  ENSSLTKEVQDLKAKQND--QVSFASLVEELKKVIHEKDGKIKSVEE-LLEAELLKVANK 827

Query: 142  LQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQ- 200
             + + DL+Q+   +K +   +       ++++++L+     +  K Q+L++L+   ++Q 
Sbjct: 828  EKTVQDLKQEIKALKEEIGNVQ------LEKAQQLS-----ITSKVQELQNLLKGKEEQM 876

Query: 201  ---KERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQP-KELGDAHDVQIHLRCSQ 256
               K  +++ E  L    ++ Q  +E    +K+   E  +   KE   A   +      +
Sbjct: 877  NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLK 936

Query: 257  EKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKA---EE 313
            EK+  +  L  +      D+ S  Q         K  + Q+E L++ + +  +     EE
Sbjct: 937  EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEE 996

Query: 314  YGRTLS-RSVEYCAMRDEINELKDSFKDIKKKFNNLK---------FNYTKKNEKSRNLK 363
              + +S R  E   + +E++ LKD+ +  +KK N+L+            T+K  + +  K
Sbjct: 997  LLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNK 1056

Query: 364  ALKYQIQQVD-MYAEKMQALKRKMEKVSNKTSDSFLNY----------------PSDKVN 406
              K + QQV+ +  E  + LK+   KVS  ++ S+  +                 S++V 
Sbjct: 1057 TSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVK 1116

Query: 407  VLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTE 466
            VL   +K+  +           YK  L  TE   + ++             V   +   +
Sbjct: 1117 VLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS-----------VEQEENKWK 1165

Query: 467  CKTKEAVKILHQQFNKFIAPSVPQQEERIQ-EATDLAQHLYGLEEGQKYIEKIVTKHKEV 525
             K  E+ K + Q  + F   S  Q+ ER++ E  D+       E  +  +EK   +    
Sbjct: 1166 VKVDESHKTIKQMQSSFT--SSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTY 1223

Query: 526  LESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQ 585
            +  V EL + LTEL++KL       +  N E      ++LLK       T    E+N+ Q
Sbjct: 1224 VTEVRELKDLLTELQKKLDDSYSEAVRQNEE------LNLLKAQLNETLTKLRTEQNERQ 1277

Query: 586  VQVADL 591
                DL
Sbjct: 1278 KVAGDL 1283



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 108/547 (19%), Positives = 212/547 (38%), Gaps = 70/547 (12%)

Query: 17   KEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKN 76
            KE  D KAK     +       LKK    +D  ++ +  +    E E+L V N+   +++
Sbjct: 777  KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL---LEAELLKVANKEKTVQD 833

Query: 77   TMENQKAEREELSLLRL--AWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVS 134
              +  KA +EE+  ++L  A QL  T      Q     KE+   T        +A++   
Sbjct: 834  LKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNT-------MKAVLEEK 886

Query: 135  ALDLGGSLQFILDLRQKWNDMKPQFQQLN-------------DEVQYIMKESEE------ 175
              DL  + +++ DL+++   +K   Q++              +E++ ++KE E       
Sbjct: 887  EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE 946

Query: 176  --LTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSREL 233
              L  R + +  K+Q L+D+   ++  K +I+  +   Y+        EEL ++I  RE 
Sbjct: 947  AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 1006

Query: 234  EFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNL 293
            E      EL    D   H R         +     AL+    ++         N ++K  
Sbjct: 1007 EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK-----VNKTSKER 1061

Query: 294  QQQLELLEEDSMKWRAKA---------EEYGRTL---SRSVEYC----AMRDEINELKDS 337
            QQQ+E +E ++ +   K            YG  L    +  + C    +  +E+  L+  
Sbjct: 1062 QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHK 1121

Query: 338  FKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQ-VDMYAEKMQALKRKMEKVSNKTSDS 396
             K+  +    L+    K        + +  ++Q+ V+    K +    +  K   +   S
Sbjct: 1122 LKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSS 1181

Query: 397  FLNYPSD-----KVNVLLEVMKDLQKHVD-DFDKVVTDYKKNLDLTEHFQEVIEECHFWY 450
            F +   +       N  +E ++  ++H++ + +K   +    +      ++++ E     
Sbjct: 1182 FTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKL 1241

Query: 451  EDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEE 510
            +D+         YS   +  E + +L  Q N+ +     +Q ER + A DL +    LE 
Sbjct: 1242 DDS---------YSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLEL 1292

Query: 511  GQKYIEK 517
             Q  I K
Sbjct: 1293 IQSKIVK 1299



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 121/573 (21%), Positives = 227/573 (39%), Gaps = 79/573 (13%)

Query: 59   AKENEILDVKNEVYLMKNTME-------NQKAEREELSLLRLAWQLKATESKPGKQQWAA 111
            +KE E+ D++N  +L+K  ++        Q A   EL  ++ +  +K  + +  ++Q   
Sbjct: 632  SKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ--- 688

Query: 112  FKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMK 171
             + ++       K+L +      AL         L   Q   D+  Q ++   E    +K
Sbjct: 689  LQHEISNKMEEFKILND---QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 745

Query: 172  ESEELTGRG-APVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKS 230
              EEL   G   V  K ++L  +   +    + +QD +      V F  + EEL ++I  
Sbjct: 746  TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805

Query: 231  RELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSA 290
            ++ + ++  +EL +A  +++       K+  V  L +   +L  + I +VQ      +S 
Sbjct: 806  KDGK-IKSVEELLEAELLKV-----ANKEKTVQDLKQEIKALKEE-IGNVQLEKAQQLSI 858

Query: 291  KNLQQQLELL----EEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINE-LKDSFKDIKK-- 343
             +  Q+L+ L    EE     +A  EE  + L+ + ++     E NE LK   +++ +  
Sbjct: 859  TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 918

Query: 344  --------KFNNLKFNYTKKNEKSRNLKA--------LKYQIQQVDMYAEKMQALKRKME 387
                    +F  L+    +K  + + L+A        L  + Q +    ++ +  K ++E
Sbjct: 919  LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978

Query: 388  KVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDF--------DKVVTDYKKNLDLTEHF 439
            ++  +      ++P  +   LL+V+ + +K +           D V    KKN DL E  
Sbjct: 979  QLKQQNYQQASSFPPHE--ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKN 1036

Query: 440  QEVIE---ECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQ 496
             E +E         +D      +  +   E    EA ++L + F K   PS         
Sbjct: 1037 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPS--------- 1087

Query: 497  EATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLE 556
                  + L+G E+          K KE +   T   E +  LE KLK+ D +     LE
Sbjct: 1088 -NLSYGEWLHGFEK----------KAKECMAG-TSGSEEVKVLEHKLKEADEMHTLLQLE 1135

Query: 557  DFHYDYIDLLKEPAKNK-QTIFNEERNKGQVQV 588
               Y  +    E    K Q    +E NK +V+V
Sbjct: 1136 CEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1168


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 118/546 (21%), Positives = 225/546 (41%), Gaps = 73/546 (13%)

Query: 86   EELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHN----LKLLQEALMPVSALDLGGS 141
            E  SL +    LKA ++   +  +A+  E+LKK  H     +K ++E L+    L +   
Sbjct: 771  ENSSLTKEVQDLKAKQND--QVSFASLVEELKKVIHEKDGKIKSVEE-LLEAELLKVANK 827

Query: 142  LQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQ- 200
             + + DL+Q+   +K +   +       ++++++L+     +  K Q+L++L+   ++Q 
Sbjct: 828  EKTVQDLKQEIKALKEEIGNVQ------LEKAQQLS-----ITSKVQELQNLLKGKEEQM 876

Query: 201  ---KERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQP-KELGDAHDVQIHLRCSQ 256
               K  +++ E  L    ++ Q  +E    +K+   E  +   KE   A   +      +
Sbjct: 877  NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLK 936

Query: 257  EKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKA---EE 313
            EK+  +  L  +      D+ S  Q         K  + Q+E L++ + +  +     EE
Sbjct: 937  EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEE 996

Query: 314  YGRTLS-RSVEYCAMRDEINELKDSFKDIKKKFNNLK---------FNYTKKNEKSRNLK 363
              + +S R  E   + +E++ LKD+ +  +KK N+L+            T+K  + +  K
Sbjct: 997  LLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNK 1056

Query: 364  ALKYQIQQVD-MYAEKMQALKRKMEKVSNKTSDSFLNY----------------PSDKVN 406
              K + QQV+ +  E  + LK+   KVS  ++ S+  +                 S++V 
Sbjct: 1057 TSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVK 1116

Query: 407  VLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTE 466
            VL   +K+  +           YK  L  TE   + ++             V   +   +
Sbjct: 1117 VLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS-----------VEQEENKWK 1165

Query: 467  CKTKEAVKILHQQFNKFIAPSVPQQEERIQ-EATDLAQHLYGLEEGQKYIEKIVTKHKEV 525
             K  E+ K + Q  + F   S  Q+ ER++ E  D+       E  +  +EK   +    
Sbjct: 1166 VKVDESHKTIKQMQSSFT--SSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTY 1223

Query: 526  LESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQ 585
            +  V EL + LTEL++KL       +  N E      ++LLK       T    E+N+ Q
Sbjct: 1224 VTEVRELKDLLTELQKKLDDSYSEAVRQNEE------LNLLKAQLNETLTKLRTEQNERQ 1277

Query: 586  VQVADL 591
                DL
Sbjct: 1278 KVAGDL 1283



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 108/547 (19%), Positives = 212/547 (38%), Gaps = 70/547 (12%)

Query: 17   KEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKN 76
            KE  D KAK     +       LKK    +D  ++ +  +    E E+L V N+   +++
Sbjct: 777  KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL---LEAELLKVANKEKTVQD 833

Query: 77   TMENQKAEREELSLLRL--AWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVS 134
              +  KA +EE+  ++L  A QL  T      Q     KE+   T        +A++   
Sbjct: 834  LKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNT-------MKAVLEEK 886

Query: 135  ALDLGGSLQFILDLRQKWNDMKPQFQQLN-------------DEVQYIMKESEE------ 175
              DL  + +++ DL+++   +K   Q++              +E++ ++KE E       
Sbjct: 887  EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE 946

Query: 176  --LTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSREL 233
              L  R + +  K+Q L+D+   ++  K +I+  +   Y+        EEL ++I  RE 
Sbjct: 947  AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 1006

Query: 234  EFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNL 293
            E      EL    D   H R         +     AL+    ++         N ++K  
Sbjct: 1007 EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK-----VNKTSKER 1061

Query: 294  QQQLELLEEDSMKWRAKA---------EEYGRTL---SRSVEYC----AMRDEINELKDS 337
            QQQ+E +E ++ +   K            YG  L    +  + C    +  +E+  L+  
Sbjct: 1062 QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHK 1121

Query: 338  FKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQ-VDMYAEKMQALKRKMEKVSNKTSDS 396
             K+  +    L+    K        + +  ++Q+ V+    K +    +  K   +   S
Sbjct: 1122 LKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSS 1181

Query: 397  FLNYPSD-----KVNVLLEVMKDLQKHVD-DFDKVVTDYKKNLDLTEHFQEVIEECHFWY 450
            F +   +       N  +E ++  ++H++ + +K   +    +      ++++ E     
Sbjct: 1182 FTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKL 1241

Query: 451  EDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEE 510
            +D+         YS   +  E + +L  Q N+ +     +Q ER + A DL +    LE 
Sbjct: 1242 DDS---------YSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLEL 1292

Query: 511  GQKYIEK 517
             Q  I K
Sbjct: 1293 IQSKIVK 1299



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 121/573 (21%), Positives = 227/573 (39%), Gaps = 79/573 (13%)

Query: 59   AKENEILDVKNEVYLMKNTME-------NQKAEREELSLLRLAWQLKATESKPGKQQWAA 111
            +KE E+ D++N  +L+K  ++        Q A   EL  ++ +  +K  + +  ++Q   
Sbjct: 632  SKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ--- 688

Query: 112  FKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMK 171
             + ++       K+L +      AL         L   Q   D+  Q ++   E    +K
Sbjct: 689  LQHEISNKMEEFKILND---QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 745

Query: 172  ESEELTGRG-APVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKS 230
              EEL   G   V  K ++L  +   +    + +QD +      V F  + EEL ++I  
Sbjct: 746  TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805

Query: 231  RELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSA 290
            ++ + ++  +EL +A  +++       K+  V  L +   +L  + I +VQ      +S 
Sbjct: 806  KDGK-IKSVEELLEAELLKV-----ANKEKTVQDLKQEIKALKEE-IGNVQLEKAQQLSI 858

Query: 291  KNLQQQLELL----EEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINE-LKDSFKDIKK-- 343
             +  Q+L+ L    EE     +A  EE  + L+ + ++     E NE LK   +++ +  
Sbjct: 859  TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 918

Query: 344  --------KFNNLKFNYTKKNEKSRNLKA--------LKYQIQQVDMYAEKMQALKRKME 387
                    +F  L+    +K  + + L+A        L  + Q +    ++ +  K ++E
Sbjct: 919  LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978

Query: 388  KVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDF--------DKVVTDYKKNLDLTEHF 439
            ++  +      ++P  +   LL+V+ + +K +           D V    KKN DL E  
Sbjct: 979  QLKQQNYQQASSFPPHE--ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKN 1036

Query: 440  QEVIE---ECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQ 496
             E +E         +D      +  +   E    EA ++L + F K   PS         
Sbjct: 1037 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPS--------- 1087

Query: 497  EATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLE 556
                  + L+G E+          K KE +   T   E +  LE KLK+ D +     LE
Sbjct: 1088 -NLSYGEWLHGFEK----------KAKECMAG-TSGSEEVKVLEHKLKEADEMHTLLQLE 1135

Query: 557  DFHYDYIDLLKEPAKNK-QTIFNEERNKGQVQV 588
               Y  +    E    K Q    +E NK +V+V
Sbjct: 1136 CEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1168


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 129/624 (20%), Positives = 249/624 (39%), Gaps = 94/624 (15%)

Query: 16  QKEQDDAKA--KHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYL 73
           +KEQD  K   KH  +S  K+    ++ +   +DL  + L     A E  +  +   V L
Sbjct: 313 KKEQDYTKLEEKHNEESVSKK---NIQATLHQKDLDCQQLQSRLSASETSLHRI--HVEL 367

Query: 74  MKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPV 133
            +     QK  +EELS +   +Q    E K  +QQ      + +K  H L+L  E     
Sbjct: 368 SEKGEATQKL-KEELSEVETKYQHLKAEFKQLQQQ------REEKEQHGLQLQSEINQLH 420

Query: 134 SAL-----DLGG-----------SLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELT 177
           S L      LG            S + ++D  Q+  D++ +  +L ++++  +  S EL 
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480

Query: 178 GRGAPVKEKSQQLKDLIHFHQ-KQKERIQDYEDILYKVVQFHQVKEELGRLI-KSRE-LE 234
            +    K++ Q+ + L      K +E   D E +L ++    Q  + L  L+ KS+E + 
Sbjct: 481 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540

Query: 235 FVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQ 294
            +E+ +E     D+   ++  + + A ++ L     +L   +    ++    + S K  Q
Sbjct: 541 LLEKERE-----DLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ 595

Query: 295 QQL-ELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYT 353
           + L + ++E     RA  +   R LS       +   +NEL     + K+K + L     
Sbjct: 596 ENLHDQVQEQKAHLRAAQD---RVLS-------LETSVNELNSQLNESKEKVSQLDIQIK 645

Query: 354 KKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSF--LNYPSDKVNVLLEV 411
            K E   + +A K   Q+ D        L+  ++   N   D    LN  + +++ +   
Sbjct: 646 AKTELLLSAEAAK-TAQRAD--------LQNHLDTAQNALQDKQQELNKITTQLDQVTAK 696

Query: 412 MKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIE-----------ECHFWYEDASATVVRV 460
           ++D Q+H    +  + +YK+     E   E +E           E     E A   + + 
Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ 756

Query: 461 GKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYI----- 515
            + +T+ + +        +  K I  S     ++  EA +  +     +E +K I     
Sbjct: 757 RQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDF 816

Query: 516 ----EKIVTKHKE----VLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLK 567
               ++   +H+E    +  +VTEL +   E E  + +   +K          D +  + 
Sbjct: 817 ETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK----------DKLSKVS 866

Query: 568 EPAKNKQTIFNEERNKGQVQVADL 591
           +  KN ++ F +E  KG+  + DL
Sbjct: 867 DSLKNSKSEFEKENQKGKAAILDL 890



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 86/438 (19%), Positives = 186/438 (42%), Gaps = 55/438 (12%)

Query: 53   LNLINMAKE---NEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQW 109
            L  + M KE    E+  VK+++  + ++++N K+E E+             E++ GK   
Sbjct: 841  LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK-------------ENQKGKAAI 887

Query: 110  AAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILD----LRQKWNDMKPQFQQLNDE 165
               ++  K+  H L++  E  +     +L  SL+   +    L+ + N M+ Q  Q  + 
Sbjct: 888  LDLEKTCKELKHQLQVQMENTLKEQK-ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 946

Query: 166  VQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELG 225
            ++   KE ++L G    +K+ S+Q K       KQ E +Q   ++   V+Q  +++ +L 
Sbjct: 947  LKQNEKEEQQLQGNINELKQSSEQKK-------KQIEALQG--ELKIAVLQKTELENKLQ 997

Query: 226  RLIKSRELEFVEQPKELGDAHDVQIHLRCSQE--KQARVDHLHRLALSLGVDIISSVQRP 283
            + +     E   + +++     +Q +   SQE  KQ + D   R +     +++++ Q  
Sbjct: 998  QQLTQAAQELAAEKEKIS---VLQNNYEKSQETFKQLQSDFYGRES-----ELLATRQ-- 1047

Query: 284  HCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSR-SVEYCAMRDEINELKDSFKDIK 342
                   K+++++L L +ED +  R +     + +         +  +  + +   ++  
Sbjct: 1048 -----DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC 1102

Query: 343  KKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNK-TSDSFLNYP 401
            K   +++   + K ++  N K+   +I+++    EK +  K   E  S+K  S   +   
Sbjct: 1103 KALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK-EITKLNEELKSHKLESIKEITNL 1161

Query: 402  SDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVG 461
             D   +L++   +LQ   D     V   K+N  + +   +  EE     E     + +  
Sbjct: 1162 KDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE-----ELKKEFIEKEA 1216

Query: 462  KYSTECKTKEAVKILHQQ 479
            K  +E K KE     H++
Sbjct: 1217 KLHSEIKEKEVGMKKHEE 1234



 Score = 33.9 bits (76), Expect = 0.68
 Identities = 96/496 (19%), Positives = 207/496 (41%), Gaps = 62/496 (12%)

Query: 80  NQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLG 139
           N   +R++++LLR   +++  ++   +++W  + E+LKK     + LQ+       L   
Sbjct: 77  NLALKRDDVTLLRQ--EVQDLQASLKEEKW--YSEELKKELEKYQGLQQQEAKPDGL--- 129

Query: 140 GSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLK-DLIHFHQ 198
                + D   +   ++ Q ++   E  + +K+ ++L       ++K+ QL  ++     
Sbjct: 130 -----VTDSSAELQSLEQQLEEAQTE-NFNIKQMKDL------FEQKAAQLATEIADIKS 177

Query: 199 KQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEK 258
           K  E     E    KV +  +   +   +I+  + E +++P       DV +  +   + 
Sbjct: 178 KYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRP----GIEDVAVLKKELVQV 233

Query: 259 QARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTL 318
           Q  +D++     +L  +  S   +  C     K LQ Q    E    + R++  +  + +
Sbjct: 234 QTLMDNM-----TLERERESEKLKDEC-----KKLQSQYASSEATISQLRSELAKGPQEV 283

Query: 319 SRSV-EYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAE 377
           +  V E   ++  +NEL    + + +     + +YTK  EK       K  I Q  ++ +
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI-QATLHQK 342

Query: 378 KMQALKRKMEKVSNKTSDSFLNYPSDKVNV-LLEVMKDLQKHVDDFDKVVTDYKKNLDLT 436
            +   + +    +++TS         +++V L E  +  QK  ++  +V T Y+      
Sbjct: 343 DLDCQQLQSRLSASETS-------LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEF 395

Query: 437 EHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQ 496
           +  Q+  EE         + + ++  +S   +T+  +   H +  +    S  +  ++ Q
Sbjct: 396 KQLQQQREEKEQHGLQLQSEINQL--HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453

Query: 497 EATDLAQHLYGLEEG-----------QKYIEKIVTKHKE---VLESVT-ELCESLTELEE 541
           +  DL   L  LEE            Q  ++K   +H+E   + +S T +L E+  +LE+
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513

Query: 542 KLKQ-GDVLKMNPNLE 556
            L+Q GD  +   NLE
Sbjct: 514 VLRQIGDKDQKIQNLE 529


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 117/564 (20%), Positives = 241/564 (42%), Gaps = 69/564 (12%)

Query: 61   ENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPG-KQQWAAFKEQLKKT 119
            E+++L++ N +   +  ++    E+EE+  ++ A Q++  + K   K+  A  KE  +K 
Sbjct: 1568 ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKE 1627

Query: 120  SHNLKLL-----QEALMPVSALDLGGSLQFI-LDLRQKWNDMKPQFQQLN-DEVQYIMKE 172
               LK+      QE +  +  L      Q + L+  +  N    Q    N +E++ + KE
Sbjct: 1628 YQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKE 1687

Query: 173  SEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVK-EELGRLIKSR 231
             ++L      +K +  QLK+ +     +    Q+   I++  ++ HQ   ++L  ++  +
Sbjct: 1688 RDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEK 1747

Query: 232  ELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLH-----------RLALSLGVDIISSV 280
              E     K+L  ++D         +++ R+ H+H           R  +S   D +S++
Sbjct: 1748 TNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNM 1807

Query: 281  QRPHCSNVSAKNLQQ---------QLELLEEDSMKWRAKAEEYGR----------TLSR- 320
            Q+    N +AK  ++         QL  L++D  + + K  E  +          TLS+ 
Sbjct: 1808 QKD-LENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKL 1866

Query: 321  SVEYCAMRDEINELKDSFKDIKKKFNNLK-FNYTKKNEKSRNLKALKYQIQQVDMYAEKM 379
             +E   +  +++E  +  K + K+ +NL+    T K E+ + LK    + +  D+  ++ 
Sbjct: 1867 EIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQ-LKESLQETKARDLEIQQE 1925

Query: 380  QALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTD-YKKNLDLTEH 438
                R + K   +T D      S+K   + ++ KDL K  D+  K + +  KK L L   
Sbjct: 1926 LKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRV 1985

Query: 439  FQEV------IEEC-----HFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPS 487
             ++V      I E       F  ++ S   VR+  +    K  E+++ +       I   
Sbjct: 1986 KEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR------IVAK 2039

Query: 488  VPQQEERIQEATDLA--QHLYGLEE---GQKYIEKIVTKHKEVLESVTELCESLTELEEK 542
               +  RI+E+  +   Q +  L E     +   ++  + + + +    L ESL E   +
Sbjct: 2040 ERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSR 2099

Query: 543  LKQGDVLKMNPNLEDFHYDYIDLL 566
            +K  ++LK    ++D HY+ ++ L
Sbjct: 2100 IK--ELLKRYSEMDD-HYECLNRL 2120



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 127/645 (19%), Positives = 262/645 (40%), Gaps = 140/645 (21%)

Query: 55   LINMAKENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKE 114
            L N+  E +I D++ E   +   +E  +A REE+ LL     L +   +  K+     +E
Sbjct: 713  LCNLELEGKITDLQKE---LNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEE 769

Query: 115  QLKKTSHNLKLLQEALMPVSALDLGGSLQFI----------------------------L 146
                TS   KL  E +   S +   G L+ I                            +
Sbjct: 770  LHIITSEKDKLFSEVVHKESRVQ--GLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHM 827

Query: 147  DLRQKWNDMKPQFQQLNDEVQYIMKESEEL-TGRGAPVKEKSQQLKDLIHFHQKQKERIQ 205
            D  QK+  +  + +++N E+  + KE+++  +  GA   E S + ++L    ++ +ER+ 
Sbjct: 828  DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLN 887

Query: 206  DYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHL 265
            + E          Q+KE+L    +   L+ VE+ K L            +++ Q  ++ +
Sbjct: 888  EME----------QLKEQLEN--RDSTLQTVEREKTL-----------ITEKLQQTLEEV 924

Query: 266  HRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYC 325
              L                      K LQ+ L+ +E D +K      +   T++ +++  
Sbjct: 925  KTLTQ---------------EKDDLKQLQESLQ-IERDQLK-----SDIHDTVNMNID-- 961

Query: 326  AMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRK 385
              ++++    +S K  ++  N LK   ++  E SRNL   +   +  D + +KM  + +K
Sbjct: 962  -TQEQLRNALESLKQHQETINTLKSKISE--EVSRNLHMEENTGETKDEFQQKMVGIDKK 1018

Query: 386  MEKVSNKT-------SDSFLNYPSDKVNVLLEVMKDLQKHVD----DFDKVVTDYKKNLD 434
             +  +  T        D+ +     K+  L++   +LQ+ ++    + +++ TD K+N++
Sbjct: 1019 QDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIE 1078

Query: 435  LTEHFQEVI--------EECHFWYEDASATVVRVGKYSTEC----KTKEAVKILHQQFNK 482
            +T   QE +        ++     ++ +  + + G+ S  C    + +E +K   QQ  +
Sbjct: 1079 MTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQE 1138

Query: 483  ------FIAPSVPQQEERIQEATDLAQHLYG------------LEEGQKYIE-----KIV 519
                   +   + + +++I E  +L   L              LE  QK  E     K +
Sbjct: 1139 KQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSI 1198

Query: 520  TKHKEVLESVTELCES--------LTELEEK-LKQGDVLKMNPNLEDFHYDYIDLLKEPA 570
            TK ++VL+ + +  E+        + E+E   L+  + LK+       H + ID L+   
Sbjct: 1199 TKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSV 1258

Query: 571  KNK--QTIFNEERNKGQVQVADLLGINGTGEERLPQDLKVSTDKE 613
              K  Q I  ++  K   ++ + + +    +E LP   +VS  +E
Sbjct: 1259 SEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQE 1303



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 112/567 (19%), Positives = 225/567 (39%), Gaps = 107/567 (18%)

Query: 82   KAEREELSLLRLAWQLKATESKPGKQQWAAFKEQL---------KKTSHNLKLLQEALMP 132
            K + E ++ LR+    K TE    ++Q  A  ++L         K+   N+K + E    
Sbjct: 1487 KEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEK 1546

Query: 133  VSALDLGGSLQFILD-----LRQKWNDMKPQFQQLNDEVQYIMKESEELTG--------- 178
            V+ L      +   D     +  K  ++  + Q+  +E+Q ++KE EE+           
Sbjct: 1547 VNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIER 1606

Query: 179  -------------------------RGAPVKEKSQQLKDLIHFHQK---QKERIQDYEDI 210
                                     +   V E  +++ ++ H  ++   QK  +++ E  
Sbjct: 1607 DQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETE 1666

Query: 211  LYKVVQ-FHQVKEELGRLIKSR-ELEFVEQPKELGDAHDVQIHLR------CSQEKQARV 262
              ++ Q  H+  EE+  + K R +L  VE+  ++ +   ++ +LR        ++++ ++
Sbjct: 1667 NIRLTQILHENLEEMRSVTKERDDLRSVEETLKV-ERDQLKENLRETITRDLEKQEELKI 1725

Query: 263  DHLHRLALSLGVDIISSVQRPHCSNVS--AKNLQQQLELLEEDSMKWRAKAEEYGRTLSR 320
             H+H       +D +  +     + +S   K+L+   + L+   +K + +       L  
Sbjct: 1726 VHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKE 1785

Query: 321  SVEYC-AMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKM 379
              E    +R  ++E  D   +++K   N   +  K  EK + LKA ++Q+  +     + 
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLEN---SNAKLQEKIQELKANEHQLITLKKDVNET 1842

Query: 380  QALKRKMEKVSNKTSDSFLNYP---------SDKVNVLLEVMKDLQKHVDDFDKVVTDYK 430
            Q    +ME++  +  D  L            + K++  LE MK + K  D+  +V    K
Sbjct: 1843 QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLK 1902

Query: 431  KNLD-LTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVP 489
               D L E  QE              T  R  +   E KT   +   H++       +V 
Sbjct: 1903 LERDQLKESLQE--------------TKARDLEIQQELKTARMLSKEHKE-------TVD 1941

Query: 490  QQEERIQEAT----DLAQHL-YGLEEGQKYIEKIVTKHKEVL---ESVTELCESLTELEE 541
            +  E+I E T    D+ + L    +E QK I+++  K  ++L   E V    + + E+E+
Sbjct: 1942 KLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQ 2001

Query: 542  KLKQGDVLKMNPNLEDFHYDYIDLLKE 568
              KQ +    N +++    D   L K+
Sbjct: 2002 LKKQFEA--QNLSMQSVRMDNFQLTKK 2026



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 140/632 (22%), Positives = 269/632 (42%), Gaps = 110/632 (17%)

Query: 11   ETEIPQKEQDDAKAKH------CSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKE--- 61
            + EI  +E++ A  K       C   AE + +L  +KS   Q+   + LN+     E   
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL-KEKSQQLQEKQQQLLNVQEEMSEMQK 1155

Query: 62   --NEILDVKNEVYLMKNTMENQKAEREELS--LLRLAWQLKA--TESKPGKQQWAAF--- 112
              NEI ++KNE+   + T+E+ + ER EL+  L     ++K+   E K  K+   +F   
Sbjct: 1156 KINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETE 1215

Query: 113  ------------------KEQLKKTSHNLKLLQEALMPVSALDLGGSLQFI--LDLRQKW 152
                              KE+LK    +LK  QE +  +       + Q I   DL +  
Sbjct: 1216 RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSH 1275

Query: 153  NDMKPQFQQLNDEVQYI-----MKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDY 207
              ++ +   L++E + +     + E++E       + E+S   KD     + + ER++  
Sbjct: 1276 TKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQS-TTKDSTTLARIEMERLRLN 1334

Query: 208  EDILYKVVQFHQVKEELGRLIKSRE-LEFVEQPKELGDAHD-VQIHLRCSQEKQARVDHL 265
            E       +F + +EE+  L K R+ L+ +++  E+   HD ++ H+R +  K       
Sbjct: 1335 E-------KFQESQEEIKSLTKERDNLKTIKEALEV--KHDQLKEHIRETLAKIQESQSK 1385

Query: 266  HRLALSL------GVDIISSVQ--RPHCSNVSAKNLQQQLELL--------EEDSMKWRA 309
               +L++         I+S ++  +P  S +    L+ ++E+L          D MK  A
Sbjct: 1386 QEQSLNMKEKDNETTKIVSEMEQFKPKDSAL----LRIEIEMLGLSKRLQESHDEMKSVA 1441

Query: 310  KAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKF----NNLKFNYTKKNEKSRNLKAL 365
            K ++    L R  E   ++ E ++LK++ K+I  K       LK  +    E+   +  L
Sbjct: 1442 KEKD---DLQRLQE--VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496

Query: 366  KYQIQQVDMYAEKMQ-ALKRKMEKVSNKTSDSFLNYPSDKVNVLLEV------MKDLQKH 418
            +  + + +     +Q  L+   +K+ NK  + +       +  + EV      +K  ++H
Sbjct: 1497 RVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEH 1556

Query: 419  VDDFDKVVTDYK-KNLDLTEHFQEVIEECHFWYEDAS-----ATVVRVGKYSTECKTKEA 472
                D  +   + K L+LT   QE  EE     ++          +++ +   +  TKE 
Sbjct: 1557 RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEI 1616

Query: 473  VKILHQ------QFNKFIAPSVPQQE----ERIQEATDLAQ-HLYGLEEGQKYIEKIVTK 521
            V  + +      QF K  A +  Q++    E ++E  +  + +L  +E     + +I+ +
Sbjct: 1617 VAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHE 1676

Query: 522  HKEVLESVTELCESLTELEEKLK-QGDVLKMN 552
            + E + SVT+  + L  +EE LK + D LK N
Sbjct: 1677 NLEEMRSVTKERDDLRSVEETLKVERDQLKEN 1708



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 81/436 (18%), Positives = 165/436 (37%), Gaps = 69/436 (15%)

Query: 147 DLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQD 206
           ++  + N ++  +  L  + + +  E EE+  +   +KEK+    DL  F   +++  +D
Sbjct: 495 NIESELNSLRADYDNLVLDYEQLRTEKEEMELK---LKEKN----DLDEFEALERKTKKD 547

Query: 207 YEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLH 266
            E  L      H++   L  L+K  E+   +   EL    ++       +EK+ ++  L 
Sbjct: 548 QEMQL-----IHEISN-LKNLVKHAEVYNQDLENELSSKVELL------REKEDQIKKLQ 595

Query: 267 RLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCA 326
               S  ++ I              +L   LE +E+     +   +     L    E   
Sbjct: 596 EYIDSQKLENIKM------------DLSYSLESIEDPKQMKQTLFDAETVALDAKRESAF 643

Query: 327 MRDEINELKDSFKDI----KKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQAL 382
           +R E  ELK+  K++    K+  N+++   ++   K +    L+ ++Q       K+ +L
Sbjct: 644 LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSL 703

Query: 383 ---KRKMEKVSNKTSDSFLNYPSDKVN-------------VLLEVMKDLQKHVDDFDKVV 426
              K   + + N   +  +     ++N             +LL  +K L   V+   K +
Sbjct: 704 IDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEI 763

Query: 427 TDYKKNLDL-TEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEA-----------VK 474
            D  + L + T    ++  E           +  +GK   +  T ++            K
Sbjct: 764 QDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFK 823

Query: 475 ILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCE 534
            LH  F +     + + E   QE  +L++      E QK+   +     E+     EL E
Sbjct: 824 TLHMDFEQKYKMVLEENERMNQEIVNLSK------EAQKFDSSLGALKTELSYKTQELQE 877

Query: 535 SLTELEEKLKQGDVLK 550
              E++E+L + + LK
Sbjct: 878 KTREVQERLNEMEQLK 893


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 120/600 (20%), Positives = 247/600 (41%), Gaps = 102/600 (17%)

Query: 46   QDLGLEFLNLINMAKENEILDVKNEVYLMKNTMENQKAEREE--LSLLRLAWQLKATESK 103
            Q+LG E  N +  A+E +IL ++N+VY MK  +E +K E E   LS+     +LKA E +
Sbjct: 1570 QELGEEKDNRVKEAEE-KILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDR 1628

Query: 104  PGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLN 163
               +  A   E  +K    +  +++ L+  S ++     Q+        +++  + Q+  
Sbjct: 1629 LESESAAKLAELKRKAEQKIAAIKKQLL--SQMEEKEE-QYKKGTESHLSELNTKLQERE 1685

Query: 164  DEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQD-----YEDILYKVVQFH 218
             EV  + ++ + +    +      +  K++  + ++++   Q      YE+ +  + +  
Sbjct: 1686 REVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNL 1745

Query: 219  QVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCS-QEKQARVDHLHRLALSLGVDII 277
              KE+L        L+ V Q KE  +       +RC  QE+  +++H             
Sbjct: 1746 TEKEKL--------LQRVGQEKE--ETVSSHFEMRCQYQERLIKLEHAEA---------- 1785

Query: 278  SSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEIN---EL 334
                + H       +LQ++LE           K ++Y   +++ VE    ++ I     L
Sbjct: 1786 ----KQHEDQSMIGHLQEELE----------EKNKKYSLIVAQHVEKEGGKNNIQAKQNL 1831

Query: 335  KDSFKDIKKKFNNLKFNYTKKNEKSRNLKAL--------KYQIQQVDMYAEKMQALKRK- 385
            ++ F D++K     +       +K + L +         + +++++    EK+QAL++  
Sbjct: 1832 ENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMD 1891

Query: 386  --------MEKVSNKTSDSFLNYPSDKVNVLLE------VMKDLQKHVDDFDKVVTDYKK 431
                    +E+ + + S S L  P    N+  +       +   ++      K +   +K
Sbjct: 1892 GRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQK 1951

Query: 432  NLDLT--EHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVP 489
            +L +   EH QE +E     Y+      ++  +   E K    +K L ++FN  +A    
Sbjct: 1952 DLRMLRKEHQQE-LEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQ 2010

Query: 490  QQEERIQEATDLAQHLYG------LEEGQKYIEKIVTK----------HKEVLES----- 528
            + E  I+E  + AQ +         EE  + ++KI  K          ++E+L++     
Sbjct: 2011 ELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEM 2070

Query: 529  ---VTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQ 585
               V +L   L EL++K +Q    + NP  ++     I  L+     K T+ ++ + K Q
Sbjct: 2071 TAKVRDLQTQLEELQKKYQQKLEQEENPGNDNV---TIMELQTQLAQKTTLISDSKLKEQ 2127



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 116/554 (20%), Positives = 227/554 (40%), Gaps = 99/554 (17%)

Query: 67  VKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLL 126
           VK +  L+K   E  ++ +E+ +LL        T  K       A +EQL +    L+ +
Sbjct: 288 VKRQENLLKRCKETIQSHKEQCTLL--------TSEKE------ALQEQLDERLQELEKI 333

Query: 127 QEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKES------------E 174
           ++       L +    + I  LR    D K   +QL  +   ++ E+            E
Sbjct: 334 KD-------LHMAEKTKLITQLR----DAKNLIEQLEQDKGMVIAETKRQMHETLEMKEE 382

Query: 175 ELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELE 234
           E+    + +K+ + Q ++L    QK+K     +E+ L K +   Q  EE  R +K+   E
Sbjct: 383 EIAQLRSRIKQMTTQGEELRE--QKEKSERAAFEE-LEKALSTAQKTEEARRKLKAEMDE 439

Query: 235 FVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQ 294
            ++  ++  +   + +    S+ KQ  VD + + +     + I+ +Q+ H   ++ K   
Sbjct: 440 QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS----EEQIAKLQKLHEKELARK--- 492

Query: 295 QQLELLEEDSMKWRAKAEEYGRTLSRSV-EYCAMRDEINELKDSFKDIKKKFNNLKFNYT 353
            + EL ++   + R   E+    L +S  EY  +  E  E ++S   +++     K   T
Sbjct: 493 -EQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE-KEQQESLA-LEELELQKKAILT 549

Query: 354 KKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMK 413
           +   K R+L+      Q+ + Y  ++  L+  +EK   +  +      S  + V LE  K
Sbjct: 550 ESENKLRDLQ------QEAETYRTRILELESSLEKSLQENKNQ-----SKDLAVHLEAEK 598

Query: 414 DLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAV 473
           +  KH  +   +V  +K  L+  +H Q+ +     W E      V   +Y TE +     
Sbjct: 599 N--KHNKEITVMVEKHKTELESLKHQQDAL-----WTEKLQ---VLKQQYQTEMEK---- 644

Query: 474 KILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELC 533
                     +     Q++E + +  ++    +  E  +K +EK+  K  E+    +EL 
Sbjct: 645 ----------LREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELS 694

Query: 534 ESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLG 593
           E L    +  ++  VLK          D  D +K+  + K    +E++N  Q QV  ++ 
Sbjct: 695 EVLKARHKLEEELSVLK----------DQTDKMKQELEAK---MDEQKNHHQQQVDSIIK 741

Query: 594 INGTGEERLPQDLK 607
            +    +R  + LK
Sbjct: 742 EHEVSIQRTEKALK 755



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 116/581 (19%), Positives = 248/581 (42%), Gaps = 66/581 (11%)

Query: 61   ENEILDVKNEVY-LMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLK-- 117
            + E+  VK EV  +MK + E Q A+ ++L    LA + +    K   ++   F+EQ+K  
Sbjct: 456  QQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRE-REFQEQMKVA 514

Query: 118  ---KTSHNLKLLQEALMPVS-ALD---------LGGSLQFILDLRQKWNDMKPQFQQLND 164
                 S  LK+ QE     S AL+         L  S   + DL+Q+    + +  +L  
Sbjct: 515  LEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES 574

Query: 165  EVQYIMKE----SEELTGRGAPVKEK-SQQLKDLIHFHQKQKERIQDYEDILYK-----V 214
             ++  ++E    S++L       K K ++++  ++  H+ + E ++  +D L+      +
Sbjct: 575  SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVL 634

Query: 215  VQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLAL-SLG 273
             Q +Q + E  R    +E E + + KE+      Q H+    EK      + +  L SL 
Sbjct: 635  KQQYQTEMEKLREKCEQEKETLLKDKEI----IFQAHIEEMNEKTLEKLDVKQTELESLS 690

Query: 274  VDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWR----AKAEEYGRTLSRSVEYCAMRD 329
             ++   ++  H        L+++L +L++ + K +    AK +E      + V+      
Sbjct: 691  SELSEVLKARH-------KLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEH 743

Query: 330  EINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKV 389
            E++ ++ + K +K + N L+       E+ ++LK  +  ++ ++   ++ +    ++++ 
Sbjct: 744  EVS-IQRTEKALKDQINQLELLL---KERDKHLKEHQAHVENLEADIKRSEG---ELQQA 796

Query: 390  SNKTSDSFLNYPS---DKVNVLLEVMKDLQKHVDDFD-KVVTDYKKNLDLTEHFQEVIEE 445
            S K  D F +Y S   ++     E +  LQ+ + D + + +   K+  ++    ++V  E
Sbjct: 797  SAKL-DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTE 855

Query: 446  CHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHL 505
                       + ++ K ++E + K  VK L Q +   +     +QE+  Q   +    +
Sbjct: 856  LDAHKIQVQDLMQQLEKQNSEMEQK--VKSLTQVYESKLEDGNKEQEQTKQILVEKENMI 913

Query: 506  YGLEEGQKYIEKIVTKHKEVLESVTELCESLTELE--------EKLKQGDVLKMNPNLED 557
              + EGQK   +I+T+     E    +     E +        EK+KQ    +M   L+ 
Sbjct: 914  LQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQ-KAKEMQETLKK 972

Query: 558  FHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGTG 598
               D    LK+  +N     +++  +   ++ ++   N  G
Sbjct: 973  KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAG 1013



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 101/582 (17%), Positives = 227/582 (39%), Gaps = 79/582 (13%)

Query: 50   LEFLNLINMAKENEILDVKNEVYLMKNTMENQKAERE---------ELSLLRLAWQLKAT 100
            L+    +   K+N + + + ++  ++N + + KAE E          LS+     +LKA 
Sbjct: 1566 LQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKAL 1625

Query: 101  ESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQ 160
            E +   +  A   E  +K    +  +++ L+  S ++     Q+        +++  + Q
Sbjct: 1626 EDRLESESAAKLAELKRKAEQKIAAIKKQLL--SQME-EKEEQYKKGTESHLSELNTKLQ 1682

Query: 161  QLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQV 220
            +   EV  + ++ + +    +      +  K++  + ++++    D +  + K  +    
Sbjct: 1683 EREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEE---ADSQGCVQKTYEEKIS 1739

Query: 221  KEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCS-QEKQARVDHLHRLALSLGVDIISS 279
              +     K + L+ V Q KE  +       +RC  QE+  +++H              +
Sbjct: 1740 VLQRNLTEKEKLLQRVGQEKE--ETVSSHFEMRCQYQERLIKLEH--------------A 1783

Query: 280  VQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEI---NELKD 336
              + H       +LQ++LE           K ++Y   +++ VE    ++ I     L++
Sbjct: 1784 EAKQHEDQSMIGHLQEELE----------EKNKKYSLIVAQHVEKEGGKNNIQAKQNLEN 1833

Query: 337  SFKDIKKKFNNLKFNYTKKNEKSRNLKAL--------KYQIQQVDMYAEKMQALKRK--- 385
             F D++K     +       +K + L +         + +++++    EK+QAL++    
Sbjct: 1834 VFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGR 1893

Query: 386  ------MEKVSNKTSDSFLNYP------SDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNL 433
                  +E+ + + S S L  P        + N L   +   ++      K +   +K+L
Sbjct: 1894 NKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDL 1953

Query: 434  D-LTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQE 492
              L +  Q+ +E     Y+      ++  +   E K    +K L ++FN  +A    + E
Sbjct: 1954 RMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELE 2013

Query: 493  ERIQEATDLAQHLYG------LEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQG 546
              I+E  + AQ +         EE  + ++KI  K  + L+   +  E + +  E+    
Sbjct: 2014 MTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDD-LKRTAKRYEEILDAREEEMTA 2072

Query: 547  DVLKMNPNLEDFHYDYIDLLKE---PAKNKQTIFNEERNKGQ 585
             V  +   LE+    Y   L++   P  +  TI   +    Q
Sbjct: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQ 2114



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 115/598 (19%), Positives = 236/598 (39%), Gaps = 97/598 (16%)

Query: 2    QFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKE 61
            +FQSLK  +E      E    + K  S+    Q  +  KK+    +     L  I+ +K 
Sbjct: 1184 EFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKT 1243

Query: 62   NEILD-----------VKNEVYLMKNTMENQKAE----REELSLLRLAWQLKATESKPGK 106
            N IL            VK  + +   T+   +A+     EE + L +++Q    + +  +
Sbjct: 1244 NAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKE 1303

Query: 107  QQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEV 166
             Q  + K  ++      + LQ+          GG+ Q      +K + +    ++L++ +
Sbjct: 1304 NQIKSMKADIESLVTEKEALQKE---------GGNQQQAAS--EKESCITQLKKELSENI 1352

Query: 167  QYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGR 226
              +    EEL  +   +   S+QL DL         ++Q+   +  K      ++++   
Sbjct: 1353 NAVTLMKEELKEKKVEISSLSKQLTDL-------NVQLQNSISLSEKEAAISSLRKQ--- 1402

Query: 227  LIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCS 286
                 + E ++Q ++L    D       S+EK + ++ +   +         +  R    
Sbjct: 1403 -YDEEKCELLDQVQDLSFKVDT-----LSKEKISALEQVDDWSNKFSEWKKKAQSRFTQH 1456

Query: 287  NVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFN 346
              + K LQ QLEL                    +S E     ++IN LK+      K+F+
Sbjct: 1457 QNTVKELQIQLEL--------------------KSKEAYEKDEQINLLKEELDQQNKRFD 1496

Query: 347  NLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVN 406
             LK     +++KS      K + ++ ++  E      R ME   + T  +       ++ 
Sbjct: 1497 CLKGE--MEDDKS------KMEKKESNLETELKSQTARIMELEDHITQKTI------EIE 1542

Query: 407  VLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGK--YS 464
             L EV+K+  +  D       ++K+ +   +HFQE+ EE     ++A   ++ +    YS
Sbjct: 1543 SLNEVLKNYNQQKD------IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYS 1596

Query: 465  TECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKE 524
             + + +   K L     + +  SV  +EE ++   D  +     E   K  E      ++
Sbjct: 1597 MKAELETKKKEL-----EHVNLSVKSKEEELKALEDRLES----ESAAKLAELKRKAEQK 1647

Query: 525  VLESVTELCESLTELEEKLKQG---DVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNE 579
            +     +L   + E EE+ K+G    + ++N  L++   + + +L+E  K+ ++  +E
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE-VHILEEKLKSVESSQSE 1704



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 107/534 (20%), Positives = 191/534 (35%), Gaps = 78/534 (14%)

Query: 112 FKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMK 171
           FK+  +K S   + LQ+AL P  A                 N   P   ++        +
Sbjct: 2   FKKLKQKISEEQQQLQQALAPAQASS---------------NSSTP--TRMRSRTSSFTE 44

Query: 172 ESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFH------------- 218
           + +E    G P +E      D   F QK + R+   E +    ++               
Sbjct: 45  QLDE----GTPNRESG----DTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRT 96

Query: 219 QVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLG----- 273
             +E L RL         + P ++    +  +    S  K+  +  L R+  SL      
Sbjct: 97  SSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGK 156

Query: 274 ----VDIISSVQRPH------CSNVSAKNLQQQLELLEEDSMKWRAK---AEEYGRTLSR 320
               V     +QR         S    K+L++  EL EE  M  +AK    EE+  +L  
Sbjct: 157 YSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEE 216

Query: 321 SVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQ 380
             +Y      I+ L+     +K++  N   N          LK L     Q +++ ++  
Sbjct: 217 KDQY------ISVLQTQVSLLKQRLRNGPMNVDV-------LKPLPQLEPQAEVFTKEEN 263

Query: 381 ALKRKMEKVSNKTSDSFLNYPSDKV----NVLLEVMKDLQKHVDDFDKVVTDYKKNL--D 434
                   V + TS   L     +V    N+L    + +Q H +    ++T  K+ L   
Sbjct: 264 PESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC-TLLTSEKEALQEQ 322

Query: 435 LTEHFQEV--IEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQE 492
           L E  QE+  I++ H   +    T +R  K   E   ++   ++ +   +       ++E
Sbjct: 323 LDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEE 382

Query: 493 ERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMN 552
           E  Q  + + Q     EE ++  EK      E LE      +   E   KLK     ++ 
Sbjct: 383 EIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIK 442

Query: 553 PNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGTGEERLPQDL 606
              +    + I L +E ++ KQ + +  +   + Q+A L  ++     R  Q+L
Sbjct: 443 TIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQEL 496


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 86/422 (20%), Positives = 179/422 (42%), Gaps = 31/422 (7%)

Query: 198  QKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKEL-GDAHDVQIHLRCSQ 256
            QK KER Q  E+ L ++ Q H    E   L++    E ++   EL  +A ++++ L   +
Sbjct: 862  QKTKERQQKAENELKELEQKHSQLTEEKNLLQ----EQLQAETELYAEAEEMRVRLAAKK 917

Query: 257  EKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEY-- 314
            ++   + H     L    D    +Q      ++ + L  + +L EE++ + + + E+   
Sbjct: 918  QELEEILHEMEARLEEEEDRGQQLQAER-KKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976

Query: 315  -GRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQ----I 369
              +      E   M D+ N+L    K ++++ ++L  N  ++ EK++NL  LK +    I
Sbjct: 977  EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036

Query: 370  QQVDMYAEKMQALKRKMEKVSNK---TSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVV 426
             ++++  +K +  ++++EK+  K    +  F    +D    + E+   L K  ++    +
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1096

Query: 427  TDYKKNLDLTEHFQEVIEECHFWYEDASATV--VRVGKYSTECKTK---EAVKILHQQFN 481
                  +    +  + I E      D    +   R  +   E + +   E ++ L  +  
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156

Query: 482  KFIAPSVPQQE---ERIQEATDLAQHL-YGLEEGQKYIEKIVTKHKEVLESVTELCESLT 537
              +  +  QQE   +R QE T L + L       +  ++++  KH + +E +TE  E   
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF- 1215

Query: 538  ELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGT 597
                K  + ++ K    LE  + D    L+   + KQ +   ++ K + QV +L      
Sbjct: 1216 ----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSD 1270

Query: 598  GE 599
            GE
Sbjct: 1271 GE 1272



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 134/649 (20%), Positives = 275/649 (42%), Gaps = 88/649 (13%)

Query: 11   ETEIPQKEQDDAKAKHCSDSAEKQW-QLFLKKSFITQDLGLEFLNLINMAKENEILDVKN 69
            E E+  KE +  K K     AE +  +L  K S +T++  L            E L  + 
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL----------QEQLQAET 900

Query: 70   EVYLMKNTMENQ-KAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLL-- 126
            E+Y     M  +  A+++EL  +    + +  E +   QQ  A ++++ +   +L+    
Sbjct: 901  ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960

Query: 127  -QEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKE 185
             +EA      L+   +   I  L  +   M  Q  +L+ E + + +   +LT   A  +E
Sbjct: 961  EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020

Query: 186  KSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDA 245
            K+   K+L     K +  I + E  L K  +  Q  E+L R ++    +F EQ  +L  A
Sbjct: 1021 KA---KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL-QA 1076

Query: 246  HDVQIHLRCSQEKQARVDHLHRL---------ALSLGVDI---ISSVQRPHCSNVSAKN- 292
               ++ ++ +++++     L RL         AL    ++   IS +Q    S  +A+N 
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136

Query: 293  -------LQQQLELLE---EDSM-------KWRAKAEEYGRTLSRSVE------------ 323
                   L ++LE L+   ED++       + RAK E+    L ++++            
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196

Query: 324  ----YCAMRDEINELKDSFKDIKKKFNNLKFNYTKKN-EKSRNLKALKYQIQQVDMYAEK 378
                +    +E+ E  + FK  K   +  K    K+N + +  L+ L    Q+V+   +K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256

Query: 379  MQALKRKMEKVSNKTSDSFLNYP--SDKVNVLLEVMKDLQKHVDDFD----KVVTDYKKN 432
            ++A   +++++ +K SD        +DKV+ L   ++ +   +++ +    K+  D    
Sbjct: 1257 LEA---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 433  LDLTEHFQEVIEECHFWYEDASATV--VRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQ 490
                +  QE+++E      + S  +  +   + S + +  E ++   Q   + I+    Q
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHISTLNIQ 1372

Query: 491  QEERIQEATDLAQHLYGLEEG----QKYIEKIVTKHKEVLESVTELCESLTELEEKLKQ- 545
              +  ++  D A  +  LEEG    QK IE +  +++E   +  +L ++   L+++L   
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432

Query: 546  ----GDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVAD 590
                 +  ++  NLE     +  LL E  KN  + + +ER++ + +  +
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEARE 1480



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 111/524 (21%), Positives = 210/524 (40%), Gaps = 91/524 (17%)

Query: 114  EQLKKTSHNLKLLQEALMPVSALDLGGSLQF------------------ILDLRQKWNDM 155
            EQ K+   NL   ++ L   +A DL G L+                   + +L+ K +D 
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENA-DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271

Query: 156  KPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQL-KDLIHFHQKQKERIQDYEDILYKV 214
            +    +LND+V  +  E E +TG     + K+ +L KD+         ++QD +++L + 
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL----SSQLQDTQELLQE- 1326

Query: 215  VQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGV 274
                + +++L    K R+LE  E+   L D  D ++  + + E+     H+  L + L  
Sbjct: 1327 ----ETRQKLNVSTKLRQLE--EERNSLQDQLDEEMEAKQNLER-----HISTLNIQLS- 1374

Query: 275  DIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTL-SRSVEYCAMRDEINE 333
                       S    ++    +E LEE   +++ + E   +    ++  Y  +    N 
Sbjct: 1375 ----------DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424

Query: 334  LKDSFKDIKKKFNN---LKFNYTKKNEKSRNLKA------LKYQIQQVDMYAE------K 378
            L+    D+    +N   L  N  KK  K   L A       KY  ++    AE      K
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484

Query: 379  MQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEV-MKDLQKHVDDFDKVVTDYKKNLDLTE 437
              +L R +E+      +       ++ N +L+  M+DL    DD  K V + +K+    E
Sbjct: 1485 ALSLARALEEALEAKEE------LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538

Query: 438  -HFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEE-RI 495
               +E+  +     ++  AT         + + +  ++ L  QF + +     Q EE R 
Sbjct: 1539 TQMEEMKTQLEELEDELQAT------EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1592

Query: 496  QEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTEL----CESLTELEEKLKQGDVLKM 551
            Q    L ++   LE+ +K         K++   + +L      ++   EE +KQ  + K+
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ--LRKL 1650

Query: 552  NPNLEDFHYDYIDLLKEPAKNKQTIF---NEERNKGQVQVADLL 592
               ++DF  +    L++   ++  IF    E   K +   ADL+
Sbjct: 1651 QAQMKDFQRE----LEDARASRDEIFATAKENEKKAKSLEADLM 1690



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 74/355 (20%), Positives = 149/355 (41%), Gaps = 35/355 (9%)

Query: 2    QFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKE 61
            Q Q     YETE+    +D+ K +  + +A+K+ +  LK      DL L+  + I   +E
Sbjct: 1593 QLQRQLHEYETEL----EDERKQRALAAAAKKKLEGDLK------DLELQADSAIKGREE 1642

Query: 62   --NEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKT 119
               ++  ++ ++   +  +E+ +A R+E+       + KA   +    Q        ++ 
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702

Query: 120  SHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGR 179
                 L +E L    A +L  SL     L+ +   ++ +  QL +E++      E ++ R
Sbjct: 1703 RKQADLEKEEL----AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758

Query: 180  GAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQP 239
                 ++++QL + +   +   ++ +     L +  Q  +++ +L  +  + + +F    
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLER--QNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 240  KELGDAHDVQIHLRCSQE---KQARVDHLHRLALSLGVDIISSVQ-----------RPHC 285
              L +A   Q+  +  QE   KQA    L +    L  +I+  V+           +   
Sbjct: 1817 AAL-EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEK 1874

Query: 286  SNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYC-AMRDEINELKDSFK 339
             N   K L++QLE  EE+S +  A   +  R L  + E   AM  E+N LK   +
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 86/422 (20%), Positives = 179/422 (42%), Gaps = 31/422 (7%)

Query: 198  QKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKEL-GDAHDVQIHLRCSQ 256
            QK KER Q  E+ L ++ Q H    E   L++    E ++   EL  +A ++++ L   +
Sbjct: 869  QKTKERQQKAENELKELEQKHSQLTEEKNLLQ----EQLQAETELYAEAEEMRVRLAAKK 924

Query: 257  EKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEY-- 314
            ++   + H     L    D    +Q      ++ + L  + +L EE++ + + + E+   
Sbjct: 925  QELEEILHEMEARLEEEEDRGQQLQAER-KKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983

Query: 315  -GRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQ----I 369
              +      E   M D+ N+L    K ++++ ++L  N  ++ EK++NL  LK +    I
Sbjct: 984  EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043

Query: 370  QQVDMYAEKMQALKRKMEKVSNK---TSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVV 426
             ++++  +K +  ++++EK+  K    +  F    +D    + E+   L K  ++    +
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1103

Query: 427  TDYKKNLDLTEHFQEVIEECHFWYEDASATV--VRVGKYSTECKTK---EAVKILHQQFN 481
                  +    +  + I E      D    +   R  +   E + +   E ++ L  +  
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163

Query: 482  KFIAPSVPQQE---ERIQEATDLAQHL-YGLEEGQKYIEKIVTKHKEVLESVTELCESLT 537
              +  +  QQE   +R QE T L + L       +  ++++  KH + +E +TE  E   
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF- 1222

Query: 538  ELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGT 597
                K  + ++ K    LE  + D    L+   + KQ +   ++ K + QV +L      
Sbjct: 1223 ----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSD 1277

Query: 598  GE 599
            GE
Sbjct: 1278 GE 1279



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 134/649 (20%), Positives = 275/649 (42%), Gaps = 88/649 (13%)

Query: 11   ETEIPQKEQDDAKAKHCSDSAEKQW-QLFLKKSFITQDLGLEFLNLINMAKENEILDVKN 69
            E E+  KE +  K K     AE +  +L  K S +T++  L            E L  + 
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL----------QEQLQAET 907

Query: 70   EVYLMKNTMENQ-KAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLL-- 126
            E+Y     M  +  A+++EL  +    + +  E +   QQ  A ++++ +   +L+    
Sbjct: 908  ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967

Query: 127  -QEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKE 185
             +EA      L+   +   I  L  +   M  Q  +L+ E + + +   +LT   A  +E
Sbjct: 968  EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027

Query: 186  KSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDA 245
            K+   K+L     K +  I + E  L K  +  Q  E+L R ++    +F EQ  +L  A
Sbjct: 1028 KA---KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL-QA 1083

Query: 246  HDVQIHLRCSQEKQARVDHLHRL---------ALSLGVDI---ISSVQRPHCSNVSAKN- 292
               ++ ++ +++++     L RL         AL    ++   IS +Q    S  +A+N 
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143

Query: 293  -------LQQQLELLE---EDSM-------KWRAKAEEYGRTLSRSVE------------ 323
                   L ++LE L+   ED++       + RAK E+    L ++++            
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203

Query: 324  ----YCAMRDEINELKDSFKDIKKKFNNLKFNYTKKN-EKSRNLKALKYQIQQVDMYAEK 378
                +    +E+ E  + FK  K   +  K    K+N + +  L+ L    Q+V+   +K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263

Query: 379  MQALKRKMEKVSNKTSDSFLNYP--SDKVNVLLEVMKDLQKHVDDFD----KVVTDYKKN 432
            ++A   +++++ +K SD        +DKV+ L   ++ +   +++ +    K+  D    
Sbjct: 1264 LEA---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 433  LDLTEHFQEVIEECHFWYEDASATV--VRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQ 490
                +  QE+++E      + S  +  +   + S + +  E ++   Q   + I+    Q
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHISTLNIQ 1379

Query: 491  QEERIQEATDLAQHLYGLEEG----QKYIEKIVTKHKEVLESVTELCESLTELEEKLKQ- 545
              +  ++  D A  +  LEEG    QK IE +  +++E   +  +L ++   L+++L   
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439

Query: 546  ----GDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVAD 590
                 +  ++  NLE     +  LL E  KN  + + +ER++ + +  +
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEARE 1487



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 111/524 (21%), Positives = 210/524 (40%), Gaps = 91/524 (17%)

Query: 114  EQLKKTSHNLKLLQEALMPVSALDLGGSLQF------------------ILDLRQKWNDM 155
            EQ K+   NL   ++ L   +A DL G L+                   + +L+ K +D 
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENA-DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278

Query: 156  KPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQL-KDLIHFHQKQKERIQDYEDILYKV 214
            +    +LND+V  +  E E +TG     + K+ +L KD+         ++QD +++L + 
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL----SSQLQDTQELLQE- 1333

Query: 215  VQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGV 274
                + +++L    K R+LE  E+   L D  D ++  + + E+     H+  L + L  
Sbjct: 1334 ----ETRQKLNVSTKLRQLE--EERNSLQDQLDEEMEAKQNLER-----HISTLNIQLS- 1381

Query: 275  DIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTL-SRSVEYCAMRDEINE 333
                       S    ++    +E LEE   +++ + E   +    ++  Y  +    N 
Sbjct: 1382 ----------DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431

Query: 334  LKDSFKDIKKKFNN---LKFNYTKKNEKSRNLKA------LKYQIQQVDMYAE------K 378
            L+    D+    +N   L  N  KK  K   L A       KY  ++    AE      K
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

Query: 379  MQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEV-MKDLQKHVDDFDKVVTDYKKNLDLTE 437
              +L R +E+      +       ++ N +L+  M+DL    DD  K V + +K+    E
Sbjct: 1492 ALSLARALEEALEAKEE------LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545

Query: 438  -HFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEE-RI 495
               +E+  +     ++  AT         + + +  ++ L  QF + +     Q EE R 
Sbjct: 1546 TQMEEMKTQLEELEDELQAT------EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599

Query: 496  QEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTEL----CESLTELEEKLKQGDVLKM 551
            Q    L ++   LE+ +K         K++   + +L      ++   EE +KQ  + K+
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ--LRKL 1657

Query: 552  NPNLEDFHYDYIDLLKEPAKNKQTIF---NEERNKGQVQVADLL 592
               ++DF  +    L++   ++  IF    E   K +   ADL+
Sbjct: 1658 QAQMKDFQRE----LEDARASRDEIFATAKENEKKAKSLEADLM 1697



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 74/355 (20%), Positives = 149/355 (41%), Gaps = 35/355 (9%)

Query: 2    QFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKE 61
            Q Q     YETE+    +D+ K +  + +A+K+ +  LK      DL L+  + I   +E
Sbjct: 1600 QLQRQLHEYETEL----EDERKQRALAAAAKKKLEGDLK------DLELQADSAIKGREE 1649

Query: 62   --NEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKT 119
               ++  ++ ++   +  +E+ +A R+E+       + KA   +    Q        ++ 
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709

Query: 120  SHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGR 179
                 L +E L    A +L  SL     L+ +   ++ +  QL +E++      E ++ R
Sbjct: 1710 RKQADLEKEEL----AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765

Query: 180  GAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQP 239
                 ++++QL + +   +   ++ +     L +  Q  +++ +L  +  + + +F    
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLER--QNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 240  KELGDAHDVQIHLRCSQE---KQARVDHLHRLALSLGVDIISSVQ-----------RPHC 285
              L +A   Q+  +  QE   KQA    L +    L  +I+  V+           +   
Sbjct: 1824 AAL-EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEK 1881

Query: 286  SNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYC-AMRDEINELKDSFK 339
             N   K L++QLE  EE+S +  A   +  R L  + E   AM  E+N LK   +
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 86/422 (20%), Positives = 179/422 (42%), Gaps = 31/422 (7%)

Query: 198  QKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKEL-GDAHDVQIHLRCSQ 256
            QK KER Q  E+ L ++ Q H    E   L++    E ++   EL  +A ++++ L   +
Sbjct: 869  QKTKERQQKAENELKELEQKHSQLTEEKNLLQ----EQLQAETELYAEAEEMRVRLAAKK 924

Query: 257  EKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEY-- 314
            ++   + H     L    D    +Q      ++ + L  + +L EE++ + + + E+   
Sbjct: 925  QELEEILHEMEARLEEEEDRGQQLQAER-KKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 983

Query: 315  -GRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQ----I 369
              +      E   M D+ N+L    K ++++ ++L  N  ++ EK++NL  LK +    I
Sbjct: 984  EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043

Query: 370  QQVDMYAEKMQALKRKMEKVSNK---TSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVV 426
             ++++  +K +  ++++EK+  K    +  F    +D    + E+   L K  ++    +
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1103

Query: 427  TDYKKNLDLTEHFQEVIEECHFWYEDASATV--VRVGKYSTECKTK---EAVKILHQQFN 481
                  +    +  + I E      D    +   R  +   E + +   E ++ L  +  
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1163

Query: 482  KFIAPSVPQQE---ERIQEATDLAQHL-YGLEEGQKYIEKIVTKHKEVLESVTELCESLT 537
              +  +  QQE   +R QE T L + L       +  ++++  KH + +E +TE  E   
Sbjct: 1164 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF- 1222

Query: 538  ELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGT 597
                K  + ++ K    LE  + D    L+   + KQ +   ++ K + QV +L      
Sbjct: 1223 ----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSD 1277

Query: 598  GE 599
            GE
Sbjct: 1278 GE 1279



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 134/649 (20%), Positives = 275/649 (42%), Gaps = 88/649 (13%)

Query: 11   ETEIPQKEQDDAKAKHCSDSAEKQW-QLFLKKSFITQDLGLEFLNLINMAKENEILDVKN 69
            E E+  KE +  K K     AE +  +L  K S +T++  L            E L  + 
Sbjct: 858  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL----------QEQLQAET 907

Query: 70   EVYLMKNTMENQ-KAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLL-- 126
            E+Y     M  +  A+++EL  +    + +  E +   QQ  A ++++ +   +L+    
Sbjct: 908  ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 967

Query: 127  -QEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKE 185
             +EA      L+   +   I  L  +   M  Q  +L+ E + + +   +LT   A  +E
Sbjct: 968  EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027

Query: 186  KSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDA 245
            K+   K+L     K +  I + E  L K  +  Q  E+L R ++    +F EQ  +L  A
Sbjct: 1028 KA---KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL-QA 1083

Query: 246  HDVQIHLRCSQEKQARVDHLHRL---------ALSLGVDI---ISSVQRPHCSNVSAKN- 292
               ++ ++ +++++     L RL         AL    ++   IS +Q    S  +A+N 
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143

Query: 293  -------LQQQLELLE---EDSM-------KWRAKAEEYGRTLSRSVE------------ 323
                   L ++LE L+   ED++       + RAK E+    L ++++            
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203

Query: 324  ----YCAMRDEINELKDSFKDIKKKFNNLKFNYTKKN-EKSRNLKALKYQIQQVDMYAEK 378
                +    +E+ E  + FK  K   +  K    K+N + +  L+ L    Q+V+   +K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263

Query: 379  MQALKRKMEKVSNKTSDSFLNYP--SDKVNVLLEVMKDLQKHVDDFD----KVVTDYKKN 432
            ++A   +++++ +K SD        +DKV+ L   ++ +   +++ +    K+  D    
Sbjct: 1264 LEA---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 433  LDLTEHFQEVIEECHFWYEDASATV--VRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQ 490
                +  QE+++E      + S  +  +   + S + +  E ++   Q   + I+    Q
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHISTLNIQ 1379

Query: 491  QEERIQEATDLAQHLYGLEEG----QKYIEKIVTKHKEVLESVTELCESLTELEEKLKQ- 545
              +  ++  D A  +  LEEG    QK IE +  +++E   +  +L ++   L+++L   
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439

Query: 546  ----GDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVAD 590
                 +  ++  NLE     +  LL E  KN  + + +ER++ + +  +
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEARE 1487



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 111/524 (21%), Positives = 210/524 (40%), Gaps = 91/524 (17%)

Query: 114  EQLKKTSHNLKLLQEALMPVSALDLGGSLQF------------------ILDLRQKWNDM 155
            EQ K+   NL   ++ L   +A DL G L+                   + +L+ K +D 
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENA-DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278

Query: 156  KPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQL-KDLIHFHQKQKERIQDYEDILYKV 214
            +    +LND+V  +  E E +TG     + K+ +L KD+         ++QD +++L + 
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL----SSQLQDTQELLQE- 1333

Query: 215  VQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGV 274
                + +++L    K R+LE  E+   L D  D ++  + + E+     H+  L + L  
Sbjct: 1334 ----ETRQKLNVSTKLRQLE--EERNSLQDQLDEEMEAKQNLER-----HISTLNIQLS- 1381

Query: 275  DIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTL-SRSVEYCAMRDEINE 333
                       S    ++    +E LEE   +++ + E   +    ++  Y  +    N 
Sbjct: 1382 ----------DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431

Query: 334  LKDSFKDIKKKFNN---LKFNYTKKNEKSRNLKA------LKYQIQQVDMYAE------K 378
            L+    D+    +N   L  N  KK  K   L A       KY  ++    AE      K
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

Query: 379  MQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEV-MKDLQKHVDDFDKVVTDYKKNLDLTE 437
              +L R +E+      +       ++ N +L+  M+DL    DD  K V + +K+    E
Sbjct: 1492 ALSLARALEEALEAKEE------LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545

Query: 438  -HFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEE-RI 495
               +E+  +     ++  AT         + + +  ++ L  QF + +     Q EE R 
Sbjct: 1546 TQMEEMKTQLEELEDELQAT------EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599

Query: 496  QEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTEL----CESLTELEEKLKQGDVLKM 551
            Q    L ++   LE+ +K         K++   + +L      ++   EE +KQ  + K+
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ--LRKL 1657

Query: 552  NPNLEDFHYDYIDLLKEPAKNKQTIF---NEERNKGQVQVADLL 592
               ++DF  +    L++   ++  IF    E   K +   ADL+
Sbjct: 1658 QAQMKDFQRE----LEDARASRDEIFATAKENEKKAKSLEADLM 1697



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 74/355 (20%), Positives = 149/355 (41%), Gaps = 35/355 (9%)

Query: 2    QFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKE 61
            Q Q     YETE+    +D+ K +  + +A+K+ +  LK      DL L+  + I   +E
Sbjct: 1600 QLQRQLHEYETEL----EDERKQRALAAAAKKKLEGDLK------DLELQADSAIKGREE 1649

Query: 62   --NEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKT 119
               ++  ++ ++   +  +E+ +A R+E+       + KA   +    Q        ++ 
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709

Query: 120  SHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGR 179
                 L +E L    A +L  SL     L+ +   ++ +  QL +E++      E ++ R
Sbjct: 1710 RKQADLEKEEL----AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1765

Query: 180  GAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQP 239
                 ++++QL + +   +   ++ +     L +  Q  +++ +L  +  + + +F    
Sbjct: 1766 VRKATQQAEQLSNELATERSTAQKNESARQQLER--QNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 240  KELGDAHDVQIHLRCSQE---KQARVDHLHRLALSLGVDIISSVQ-----------RPHC 285
              L +A   Q+  +  QE   KQA    L +    L  +I+  V+           +   
Sbjct: 1824 AAL-EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEK 1881

Query: 286  SNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYC-AMRDEINELKDSFK 339
             N   K L++QLE  EE+S +  A   +  R L  + E   AM  E+N LK   +
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 86/422 (20%), Positives = 179/422 (42%), Gaps = 31/422 (7%)

Query: 198  QKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKEL-GDAHDVQIHLRCSQ 256
            QK KER Q  E+ L ++ Q H    E   L++    E ++   EL  +A ++++ L   +
Sbjct: 862  QKTKERQQKAENELKELEQKHSQLTEEKNLLQ----EQLQAETELYAEAEEMRVRLAAKK 917

Query: 257  EKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEY-- 314
            ++   + H     L    D    +Q      ++ + L  + +L EE++ + + + E+   
Sbjct: 918  QELEEILHEMEARLEEEEDRGQQLQAER-KKMAQQMLDLEEQLEEEEAARQKLQLEKVTA 976

Query: 315  -GRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQ----I 369
              +      E   M D+ N+L    K ++++ ++L  N  ++ EK++NL  LK +    I
Sbjct: 977  EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036

Query: 370  QQVDMYAEKMQALKRKMEKVSNK---TSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVV 426
             ++++  +K +  ++++EK+  K    +  F    +D    + E+   L K  ++    +
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL 1096

Query: 427  TDYKKNLDLTEHFQEVIEECHFWYEDASATV--VRVGKYSTECKTK---EAVKILHQQFN 481
                  +    +  + I E      D    +   R  +   E + +   E ++ L  +  
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE 1156

Query: 482  KFIAPSVPQQE---ERIQEATDLAQHL-YGLEEGQKYIEKIVTKHKEVLESVTELCESLT 537
              +  +  QQE   +R QE T L + L       +  ++++  KH + +E +TE  E   
Sbjct: 1157 DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF- 1215

Query: 538  ELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGT 597
                K  + ++ K    LE  + D    L+   + KQ +   ++ K + QV +L      
Sbjct: 1216 ----KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKKKLEAQVQELQSKCSD 1270

Query: 598  GE 599
            GE
Sbjct: 1271 GE 1272



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 134/649 (20%), Positives = 275/649 (42%), Gaps = 88/649 (13%)

Query: 11   ETEIPQKEQDDAKAKHCSDSAEKQW-QLFLKKSFITQDLGLEFLNLINMAKENEILDVKN 69
            E E+  KE +  K K     AE +  +L  K S +T++  L            E L  + 
Sbjct: 851  EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLL----------QEQLQAET 900

Query: 70   EVYLMKNTMENQ-KAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLL-- 126
            E+Y     M  +  A+++EL  +    + +  E +   QQ  A ++++ +   +L+    
Sbjct: 901  ELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLE 960

Query: 127  -QEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKE 185
             +EA      L+   +   I  L  +   M  Q  +L+ E + + +   +LT   A  +E
Sbjct: 961  EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020

Query: 186  KSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDA 245
            K+   K+L     K +  I + E  L K  +  Q  E+L R ++    +F EQ  +L  A
Sbjct: 1021 KA---KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADL-QA 1076

Query: 246  HDVQIHLRCSQEKQARVDHLHRL---------ALSLGVDI---ISSVQRPHCSNVSAKN- 292
               ++ ++ +++++     L RL         AL    ++   IS +Q    S  +A+N 
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136

Query: 293  -------LQQQLELLE---EDSM-------KWRAKAEEYGRTLSRSVE------------ 323
                   L ++LE L+   ED++       + RAK E+    L ++++            
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196

Query: 324  ----YCAMRDEINELKDSFKDIKKKFNNLKFNYTKKN-EKSRNLKALKYQIQQVDMYAEK 378
                +    +E+ E  + FK  K   +  K    K+N + +  L+ L    Q+V+   +K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256

Query: 379  MQALKRKMEKVSNKTSDSFLNYP--SDKVNVLLEVMKDLQKHVDDFD----KVVTDYKKN 432
            ++A   +++++ +K SD        +DKV+ L   ++ +   +++ +    K+  D    
Sbjct: 1257 LEA---QVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 433  LDLTEHFQEVIEECHFWYEDASATV--VRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQ 490
                +  QE+++E      + S  +  +   + S + +  E ++   Q   + I+    Q
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEME-AKQNLERHISTLNIQ 1372

Query: 491  QEERIQEATDLAQHLYGLEEG----QKYIEKIVTKHKEVLESVTELCESLTELEEKLKQ- 545
              +  ++  D A  +  LEEG    QK IE +  +++E   +  +L ++   L+++L   
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432

Query: 546  ----GDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVAD 590
                 +  ++  NLE     +  LL E  KN  + + +ER++ + +  +
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFDQLLAE-EKNISSKYADERDRAEAEARE 1480



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 111/524 (21%), Positives = 210/524 (40%), Gaps = 91/524 (17%)

Query: 114  EQLKKTSHNLKLLQEALMPVSALDLGGSLQF------------------ILDLRQKWNDM 155
            EQ K+   NL   ++ L   +A DL G L+                   + +L+ K +D 
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENA-DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271

Query: 156  KPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQL-KDLIHFHQKQKERIQDYEDILYKV 214
            +    +LND+V  +  E E +TG     + K+ +L KD+         ++QD +++L + 
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL----SSQLQDTQELLQE- 1326

Query: 215  VQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGV 274
                + +++L    K R+LE  E+   L D  D ++  + + E+     H+  L + L  
Sbjct: 1327 ----ETRQKLNVSTKLRQLE--EERNSLQDQLDEEMEAKQNLER-----HISTLNIQLS- 1374

Query: 275  DIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTL-SRSVEYCAMRDEINE 333
                       S    ++    +E LEE   +++ + E   +    ++  Y  +    N 
Sbjct: 1375 ----------DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424

Query: 334  LKDSFKDIKKKFNN---LKFNYTKKNEKSRNLKA------LKYQIQQVDMYAE------K 378
            L+    D+    +N   L  N  KK  K   L A       KY  ++    AE      K
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484

Query: 379  MQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEV-MKDLQKHVDDFDKVVTDYKKNLDLTE 437
              +L R +E+      +       ++ N +L+  M+DL    DD  K V + +K+    E
Sbjct: 1485 ALSLARALEEALEAKEE------LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538

Query: 438  -HFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEE-RI 495
               +E+  +     ++  AT         + + +  ++ L  QF + +     Q EE R 
Sbjct: 1539 TQMEEMKTQLEELEDELQAT------EDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1592

Query: 496  QEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTEL----CESLTELEEKLKQGDVLKM 551
            Q    L ++   LE+ +K         K++   + +L      ++   EE +KQ  + K+
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ--LRKL 1650

Query: 552  NPNLEDFHYDYIDLLKEPAKNKQTIF---NEERNKGQVQVADLL 592
               ++DF  +    L++   ++  IF    E   K +   ADL+
Sbjct: 1651 QAQMKDFQRE----LEDARASRDEIFATAKENEKKAKSLEADLM 1690



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 74/355 (20%), Positives = 149/355 (41%), Gaps = 35/355 (9%)

Query: 2    QFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKE 61
            Q Q     YETE+    +D+ K +  + +A+K+ +  LK      DL L+  + I   +E
Sbjct: 1593 QLQRQLHEYETEL----EDERKQRALAAAAKKKLEGDLK------DLELQADSAIKGREE 1642

Query: 62   --NEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKT 119
               ++  ++ ++   +  +E+ +A R+E+       + KA   +    Q        ++ 
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702

Query: 120  SHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGR 179
                 L +E L    A +L  SL     L+ +   ++ +  QL +E++      E ++ R
Sbjct: 1703 RKQADLEKEEL----AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDR 1758

Query: 180  GAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQP 239
                 ++++QL + +   +   ++ +     L +  Q  +++ +L  +  + + +F    
Sbjct: 1759 VRKATQQAEQLSNELATERSTAQKNESARQQLER--QNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 240  KELGDAHDVQIHLRCSQE---KQARVDHLHRLALSLGVDIISSVQ-----------RPHC 285
              L +A   Q+  +  QE   KQA    L +    L  +I+  V+           +   
Sbjct: 1817 AAL-EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK-EILLQVEDERKMAEQYKEQAEK 1874

Query: 286  SNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYC-AMRDEINELKDSFK 339
             N   K L++QLE  EE+S +  A   +  R L  + E   AM  E+N LK   +
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 113/572 (19%), Positives = 226/572 (39%), Gaps = 85/572 (14%)

Query: 19   QDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKNTM 78
            Q  ++A   +D+ E+  QL   K      L  +   +   A+E E  ++  E+   K  +
Sbjct: 893  QVQSEADSLADAEERCEQLIKNKI----QLEAKIKEVTERAEEEE--EINAELTAKKRKL 946

Query: 79   ENQKAERE------ELSLLRLAWQLKATESKPGK--QQWAAFKEQLKKTSHNLKLLQEAL 130
            E++ +E +      EL+L ++  +  ATE+K     ++ A   E + K S   K LQE  
Sbjct: 947  EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETH 1006

Query: 131  MPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQL 190
                              +Q  +D++ +     D+V  + K   +L  +   ++   +Q 
Sbjct: 1007 ------------------QQTLDDLQAE----EDKVNILTKAKTKLEQQVDDLEGSLEQE 1044

Query: 191  KDLIHFHQKQKERIQ-DYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQ 249
            K L    ++ K +++ D +      +     K++L   ++ +E E      ++ D   V+
Sbjct: 1045 KKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVE 1104

Query: 250  IHLRCS-QEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDS---- 304
            I L+   +E QAR++ L      +  +  S  +     +  ++ L++  E LEE      
Sbjct: 1105 IQLQKKIKELQARIEELGE---EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1161

Query: 305  --MKWRAKAEEYGRTLSRSVEYCAMRDEI------NELKDSFKDIKKKFNNLKFNYTKKN 356
              ++   K E   + L R +E   ++ E        +  DS  ++ ++ +NL+    +K 
Sbjct: 1162 AQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQ-RVKQKL 1220

Query: 357  EKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQ 416
            EK ++   LK +   +   AE +   K  +EK+     D      + K      ++ DL 
Sbjct: 1221 EKEKS--ELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT-KEEEQQRLINDLT 1277

Query: 417  KHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKIL 476
                       +Y + LD  +     +       + AS   +   K+  E +TK    + 
Sbjct: 1278 AQRARLQTEAGEYSRQLDEKDALVSQLSRS----KQASTQQIEELKHQLEEETKAKNALA 1333

Query: 477  HQ-QFNKFIAPSVPQQEERIQEA-----------------------TDLAQHLYGLEEGQ 512
            H  Q ++     + +Q E  QE                        TD  Q    LEE +
Sbjct: 1334 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1393

Query: 513  KYIEKIVTKHKEVLESVTELCESLTELEEKLK 544
            K + + + + +E +E+V   C SL + +++L+
Sbjct: 1394 KKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQ 1425



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 104/557 (18%), Positives = 233/557 (41%), Gaps = 102/557 (18%)

Query: 53   LNLINMAK---ENEILDVKNEVYLMKNT-MENQKAEREELSLLRLAWQLKATESKPGKQQ 108
            +N++  AK   E ++ D++  +   K   M+ ++A+R+    L+LA Q    + +  KQQ
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA-QESTMDMENDKQQ 1078

Query: 109  WAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQY 168
                 E+L+K    +  L   +    A+++         L++K  +++ + ++L +E++ 
Sbjct: 1079 ---LDEKLEKKEFEISNLISKIEDEQAVEI--------QLQKKIKELQARIEELGEEIE- 1126

Query: 169  IMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLI 228
                  E   R    K++S   ++L    ++  ER+++        V+ +          
Sbjct: 1127 -----AERASRAKAEKQRSDLSREL----EEISERLEEAGGATSAQVELN---------- 1167

Query: 229  KSRELEFVEQPKELGDA---HDVQI------HLRCSQEKQARVDHLHRLA---------L 270
            K RE EF +  ++L +A   H+  +      H     E   ++D+L R+          L
Sbjct: 1168 KKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSEL 1227

Query: 271  SLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLS----------- 319
             +  D +SS       + +  NL++    LE+   + + K EE  R ++           
Sbjct: 1228 KMETDDLSS--NAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQT 1285

Query: 320  RSVEYCAMRDE----INELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVD-- 373
             + EY    DE    +++L  S +   ++   LK +  ++  K++N  A   Q  + D  
Sbjct: 1286 EAGEYSRQLDEKDALVSQLSRSKQASTQQIEELK-HQLEEETKAKNALAHALQSSRHDCD 1344

Query: 374  ----MYAEKMQA---LKRKMEKVSNKTSDSFLNYPSDKVN----------VLLEVMKDLQ 416
                 Y E+ +    L+R + K +++ +     Y +D +            L + +++ +
Sbjct: 1345 LLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1404

Query: 417  KHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKIL 476
            +HV+  +      +K     +  Q  +E+     E ++A    + K     K +   K+L
Sbjct: 1405 EHVEAVNAKCASLEKT---KQRLQNEVEDLMLDVERSNAACAALDK-----KQRNFDKVL 1456

Query: 477  H---QQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELC 533
                Q++ +  A     Q+E    +T+L +     EE    +E +  ++K + + +++L 
Sbjct: 1457 SEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLT 1516

Query: 534  ESLTELEEKLKQGDVLK 550
            E + E  +++ + + +K
Sbjct: 1517 EQIAEGGKQIHELEKIK 1533



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 102/502 (20%), Positives = 207/502 (41%), Gaps = 70/502 (13%)

Query: 81   QKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGG 140
            Q+ E  E +  +LA +L+  E++   +   A    L+KT   L+   E LM    ++   
Sbjct: 1384 QRTEELEEAKKKLAQRLQ--EAEEHVEAVNAKCASLEKTKQRLQNEVEDLM--LDVERSN 1439

Query: 141  SLQFILDLRQK-----WNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIH 195
            +    LD +Q+      ++ K ++++   E++   KES  L+     VK   ++  D + 
Sbjct: 1440 AACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLE 1499

Query: 196  FHQKQKERIQ-DYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRC 254
              +++ + +Q +  D+  ++ +  +   EL ++ K  E E  E    L            
Sbjct: 1500 TLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAAL------------ 1547

Query: 255  SQEKQARVDH----LHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAK 310
             +E +A ++H    + R+ L L   + S V R         +  ++      ++M+    
Sbjct: 1548 -EEAEASLEHEEGKILRIQLELN-QVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD 1605

Query: 311  AEEYGRTLSRSVEYCAMRDEINELK-----------DSFKDIKKKFNNLKFNYTKKNEKS 359
            AE   R  +  V+   M  ++NE++           +S ++ +     LK      ++  
Sbjct: 1606 AEIRSRNDALRVKK-KMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDAL 1664

Query: 360  RNLKALKYQIQQVDMYAEKMQA----LKRKMEKV--SNKTSDSFLNYPSDKVNVLLEVMK 413
            R  + LK Q+  V+  A  +QA    L   +E+   S K ++  L   S++V +L     
Sbjct: 1665 RGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLL----- 1719

Query: 414  DLQKHVDDFDKVVTDYKKNLDLTE---HFQEVIEECHFWYEDASATVVRVGKYSTECKTK 470
                H  +   + T  K   D+++     +EVI+E     E A   +      + E K +
Sbjct: 1720 ----HTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKE 1775

Query: 471  EAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESV- 529
            +      ++  K +  +V   + R+ EA  LA     L+ G+K I+K+  + +E+   V 
Sbjct: 1776 QDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA-----LKGGKKQIQKLEARVRELEGEVE 1830

Query: 530  ------TELCESLTELEEKLKQ 545
                   E  + L + E ++K+
Sbjct: 1831 NEQKRNAEAVKGLRKHERRVKE 1852


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 154/849 (18%), Positives = 329/849 (38%), Gaps = 132/849 (15%)

Query: 4    QSLKEFYETEIPQKE----QDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMA 59
            + L+E   T + +K     Q  A++++  D+ E+  QL +K  F    L  +   +   A
Sbjct: 872  KELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQL-IKAKF---QLEAKIKEVTERA 927

Query: 60   KENEILDVKNEVYLMKNTMENQKAERE------ELSLLRLAWQLKATESKPGK--QQWAA 111
            ++ E  ++  E+   K  +E++ +E +      EL+L ++  +  ATE+K     ++ + 
Sbjct: 928  EDEE--EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSG 985

Query: 112  FKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMK 171
              E + K +   K LQEA     ALD                      Q   D+V  + K
Sbjct: 986  LDETIAKLTREKKALQEAHQ--QALD--------------------DLQAEEDKVNSLNK 1023

Query: 172  ESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQ-DYEDILYKVVQFHQVKEELGRLIKS 230
               +L  +   ++   +Q K L    ++ K +++ D +     ++     K++L   +K 
Sbjct: 1024 TKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK 1083

Query: 231  RELEFVEQPKELGDAHDVQIHLRCS-QEKQARVDHLHRLALSLGVDIISSVQRPHCSNVS 289
            ++ E+ +   ++ D   + +  +   +E QAR++ L      +  +  +  +     +  
Sbjct: 1084 KDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEE---EIEAERATRAKTEKQRSDY 1140

Query: 290  AKNLQQQLELLEE------DSMKWRAKAEEYGRTLSRSVEYCAMRDEI------NELKDS 337
            A+ L++  E LEE        ++   K E     L R +E   ++ E        +  DS
Sbjct: 1141 ARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADS 1200

Query: 338  FKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSF 397
              ++ ++ +NL+    +K EK ++    K +I  +    E +   K  +EK+     D  
Sbjct: 1201 VAELGEQIDNLQ-RVKQKLEKEKS--EFKLEIDDLSSSMESVSKSKANLEKICRTLEDQL 1257

Query: 398  -------------LNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDL----TEHFQ 440
                         L+  + + + L     +L + +++ + +V+   ++       TE  +
Sbjct: 1258 SEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELK 1317

Query: 441  EVIEE--------CHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQE 492
              +EE         H          +   +Y  E + K  ++    + N  +A      +
Sbjct: 1318 RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA------Q 1371

Query: 493  ERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMN 552
             R +  TD  Q    LEE +K + + +   +E +E+V   C SL + +++L QG+V  + 
Sbjct: 1372 WRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRL-QGEVEDLM 1430

Query: 553  PNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGTGEERLPQDLKVSTD- 611
             ++E  +      L +  +N   +  E + K +   A+L       E  L +   +ST+ 
Sbjct: 1431 VDVERAN-SLAAALDKKQRNFDKVLAEWKTKCEESQAEL-------EASLKESRSLSTEL 1482

Query: 612  --KEGGVQDLLLPEDMLSGEEYECVSPDDISLPPLPGSPESPLAPSDMEVEEPVSSSLSL 669
               +   ++ L        ++ E V  ++ +L          +A +   + E   S   +
Sbjct: 1483 FKLKNAYEEAL--------DQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQI 1534

Query: 670  HISSYGVQAGTSSPGDAQESVLPPPVAFADACNDKRETFSSHFERPYLQFKAEPPLTSRG 729
             +    +Q                    A+A  +  E      +    Q K+E     R 
Sbjct: 1535 ELEKADIQLALEE---------------AEAALEHEEAKILRIQLELTQVKSE---IDRK 1576

Query: 730  FVEKSTALHRISAEHPESMMSEVHERALQQHPQAQGGLLETREKMHADNNFTKTQDRLHA 789
              EK   + ++   +  ++  E  + AL    +++   +  ++KM  D N  + Q   HA
Sbjct: 1577 IAEKDEEIEQLKRNYQRTV--ETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQ-LSHA 1633

Query: 790  SSDAFSGLR 798
            +  A   L+
Sbjct: 1634 NRQAAETLK 1642



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 100/489 (20%), Positives = 197/489 (40%), Gaps = 95/489 (19%)

Query: 81   QKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGG 140
            Q+ E  E +  +LA +L+ +E +   +   A    L+KT   L+   E LM    ++   
Sbjct: 1382 QRTEELEEAKKKLAQRLQDSEEQV--EAVNAKCASLEKTKQRLQGEVEDLMV--DVERAN 1437

Query: 141  SLQFILDLRQKWNDM-----KPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIH 195
            SL   LD +Q+  D      K + ++   E++  +KES  L+     +K   ++  D + 
Sbjct: 1438 SLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLE 1497

Query: 196  FHQKQKERI-QDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRC 254
              +++ + + Q+  D+  ++ +  +   EL +  K  ELE            D+Q+ L  
Sbjct: 1498 TVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKA----------DIQLAL-- 1545

Query: 255  SQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEY 314
             +E +A ++H                         AK L+ QLEL +  S   R  AE+ 
Sbjct: 1546 -EEAEAALEH-----------------------EEAKILRIQLELTQVKSEIDRKIAEK- 1580

Query: 315  GRTLSRSVEYCAMRDEINELKDSF-KDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVD 373
                          +EI +LK ++ + ++   + L      +NE  R  K ++  + +++
Sbjct: 1581 -------------DEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIE 1627

Query: 374  MYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNL 433
            +          ++   + + +++  +  S +       +KD Q H+DD  +   D K+ L
Sbjct: 1628 I----------QLSHANRQAAETLKHLRSVQGQ-----LKDTQLHLDDALRGQEDLKEQL 1672

Query: 434  DLTEH----FQEVIEECHFWYEDASATVVRVGKYSTE--CKTKEAVKILHQQFNKFIAPS 487
             + E      Q  +EE     E       R  K + +    + E V++LH Q    I   
Sbjct: 1673 AIVERRANLLQAEVEELRATLEQTE----RARKLAEQELLDSNERVQLLHTQNTSLI--- 1725

Query: 488  VPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGD 547
                +++++  TDL Q    +E+  +       K K+ +     + E L   +E+     
Sbjct: 1726 --HTKKKLE--TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELK--KEQDTSAH 1779

Query: 548  VLKMNPNLE 556
            + +M  NLE
Sbjct: 1780 LERMKKNLE 1788


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 132/641 (20%), Positives = 256/641 (39%), Gaps = 110/641 (17%)

Query: 40   KKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKA 99
            KK  +T++L  +    I MA+ NE     + + ++K +    +A+R EL  L+       
Sbjct: 1539 KKEKLTEELQ-KLQKDIEMAERNE----DHHLQVLKESEVLLQAKRAELEKLK------- 1586

Query: 100  TESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQF-ILDLRQKWNDMKPQ 158
            ++    +Q+ A    QL      L LLQ +++   A DL  +L+    ++ +K N ++  
Sbjct: 1587 SQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA-DLQEALRLGETEVTEKCNHIR-- 1643

Query: 159  FQQLNDEVQYIMKESEELTGR-GAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQF 217
                  EV+ +++E     G     + E+  QL  +    +K++E +Q    ++ + +  
Sbjct: 1644 ------EVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQ----VVLRQMSK 1693

Query: 218  HQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDII 277
            H  K EL  ++   +LE           H++Q       +   RV  L +  +++  + +
Sbjct: 1694 H--KTELKNILDMLQLE----------NHELQ---GLKLQHDQRVSELEKTQVAVLEEKL 1738

Query: 278  SSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCA--MRDEINELK 335
                    S      ++ Q +LLE D  +      E     SR+++ C   +  E  +L+
Sbjct: 1739 ELENLQQISQQQKGEIEWQKQLLERDKREIERMTAE-----SRALQSCVECLSKEKEDLQ 1793

Query: 336  DSFKDIKKKFNNLKFNYTKKNEKSR----NLKALKYQIQQVDMYAEKMQALKRKMEKVSN 391
            +     +KK    K       E S+    NL+ L+  ++++    +++  L R    + N
Sbjct: 1794 EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQ---QELDQLNRDKLSLHN 1850

Query: 392  KTS--DSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFW 449
              S     L    + VN L E + ++Q H++   + +      L  T+H   ++ E    
Sbjct: 1851 DISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDL------LHTTKHQDVLLSEQTRL 1904

Query: 450  YEDASATVVRVGKYSTECKTKEA-VKILHQQFNKFIAPSVPQ-------QEERIQEATDL 501
             +D S    R      E +TK+  +++L  +  +     V Q       Q+ER  E + L
Sbjct: 1905 QKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKL 1964

Query: 502  AQHLYGLEEGQKYIEKIVTKHKEVLESV-----------------TELCES--------- 535
                  L+E Q  +EK +T  K  L+ V                    CES         
Sbjct: 1965 ETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTK 2024

Query: 536  --LTELEEKL--KQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADL 591
              L+E E++L  K G++L +    +    D+  L  +        F  ER K + QVA L
Sbjct: 2025 RQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQ--------FLTERKKAEKQVASL 2076

Query: 592  LGINGTGEERLPQDLKVSTDKEGGVQDLLLPEDMLSGEEYE 632
                     +L ++L     +   +Q  +   ++++ + +E
Sbjct: 2077 KEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHE 2117



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 101/509 (19%), Positives = 200/509 (39%), Gaps = 71/509 (13%)

Query: 101 ESKPGKQQWAAFKEQLKKTSH--NLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQ 158
           E +  +QQ     E+ K+      LK + EA   +    L G LQ +  LRQ+  D++ Q
Sbjct: 459 EIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQ 518

Query: 159 FQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQK-QKERIQDYEDILYKVVQF 217
            ++   E+    KE ++L      +   S   KD  H H K QK   +   DI+ K  Q+
Sbjct: 519 MEKQKQEIAGKQKEIKDLQ-----IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNK--QY 571

Query: 218 HQVKEELGRLIK--SRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVD 275
            Q++  L  ++   ++E E ++  +E      +  +    ++ +  +  L     ++   
Sbjct: 572 QQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQ 631

Query: 276 IISSVQRPHCSNVSAKNLQQ----------QLELLEEDSMKWRAKAEEYGRTLSRSVEYC 325
              +           + L Q          QLE++  D+   R +  E    L    E  
Sbjct: 632 ATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVN 691

Query: 326 A-MRDEINELKDSFKDIKKKFN--NLKFNYTKKN-EKSRNLKALKYQIQQVDMYAEKMQA 381
           A ++    +L     +++ + N  + + N  K+  EK   L  L+    Q ++  E+ QA
Sbjct: 692 ASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKER-QA 750

Query: 382 LKRKMEKVS--------NKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNL 433
           LK  + K          N    + L +  D  N+L + +KD Q H+   + VV    +  
Sbjct: 751 LKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHL---NHVVDGLVRPE 807

Query: 434 DLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEE 493
           ++     E+  +      + +        +S      +++  L +QF++ +A S  +++E
Sbjct: 808 EVAARVDELRRKLKLGTGEMNI-------HSPSDVLGKSLADLQKQFSEILARSKWERDE 860

Query: 494 ------RIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGD 547
                 ++QE   L Q            EK+ T  +E  ++     E+    +++  +  
Sbjct: 861 AQVRERKLQEEMALQQ------------EKLATGQEEFRQACERALEARMNFDKRQHEAR 908

Query: 548 VLKMNPNLEDFHYDYIDLLKEPAKNKQTI 576
           + +M     + HY     L+E  K+ + I
Sbjct: 909 IQQME---NEIHY-----LQENLKSMEEI 929



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 61/265 (23%), Positives = 112/265 (42%), Gaps = 30/265 (11%)

Query: 323  EYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEK---- 378
            E+  + +E++ L+D  + +K K    ++    K +  + ++ L + I   D+  EK    
Sbjct: 1317 EHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNID--DLLQEKKSLE 1374

Query: 379  --MQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLT 436
              ++ L R ++K   +    F++   + +   LE+ K L+ H D  D++    K  L   
Sbjct: 1375 CEVEELHRTVQK--RQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRR 1432

Query: 437  EHFQEVIEECHFWYEDASATVVR----VGKYS--------TECKTKEAVKILHQQFNKFI 484
               +E          + S T  +    V K++        TE   +E  +   +     +
Sbjct: 1433 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 1492

Query: 485  APSVPQQEERIQ-EATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKL 543
                 QQ   +Q +A DL QH    EE  K I KIV       + +++  E LTE  +KL
Sbjct: 1493 --KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKL 1550

Query: 544  KQGDVLKMNPNLEDFHYDYIDLLKE 568
            ++   ++M    ED H   + +LKE
Sbjct: 1551 QKD--IEMAERNEDHH---LQVLKE 1570



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 87/467 (18%), Positives = 196/467 (41%), Gaps = 49/467 (10%)

Query: 4    QSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENE 63
            + L E  + EI +   +    + C +   K+ +   +K  I +    +   ++  A+EN 
Sbjct: 1758 KQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENS 1817

Query: 64   ILDVKN----EVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWA--AFKEQLK 117
             ++  N    E+ + K   E  +  R++LSL      + A + +  +++ A  + +E+L 
Sbjct: 1818 KMEQSNLEKLELNVRKLQQELDQLNRDKLSLHN---DISAMQQQLQEKREAVNSLQEELA 1874

Query: 118  KTSHNLKLLQEALMPVSALD---LGGSLQFILDLRQ---KWNDMKPQFQQLNDEVQYIMK 171
                +L L ++ L+  +      L    +   D+ +   ++ D + + +    ++Q +  
Sbjct: 1875 NVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQN 1934

Query: 172  ESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVV----QFHQVKEEL--- 224
            E EE          K + ++  + F + QKER  +   +    V    Q HQ+++EL   
Sbjct: 1935 EIEE---------NKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQ 1985

Query: 225  -GRL--IKSRELEFVEQPKELGDAHD--VQIHLRCSQEKQARVDHLHRLALSLGVDIISS 279
              +L  + S+ L   E+ + L +       +    SQ K+   +   +L    G   + +
Sbjct: 1986 KSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGE--LLA 2043

Query: 280  VQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEIN--ELKDS 337
            +Q+       A +++    LL    +  R KAE+   +L  +++    + E N  E K  
Sbjct: 2044 LQK------EADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQE 2097

Query: 338  FKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSF 397
               I+K+   ++      +E++R L     Q+Q      +K  A ++ +E+   + SD+ 
Sbjct: 2098 NSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAM 2157

Query: 398  LNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIE 444
                S+  + +   +K+L + + +   +  D +  L+  E+ +  +E
Sbjct: 2158 RTLKSEVKDEIRTSLKNLNQFLPE---LPADLEAILERNENLEGELE 2201


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 101/531 (19%), Positives = 222/531 (41%), Gaps = 74/531 (13%)

Query: 53   LNLINMAK---ENEILDVKNEVYLMKNT-MENQKAEREELSLLRLAWQLKATESKPGKQQ 108
            +N +  AK   E ++ D++  +   K   M+ ++A+R+    L+LA Q    +++  KQQ
Sbjct: 1021 VNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLA-QESTMDTENDKQQ 1079

Query: 109  WAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQY 168
                 E+LKK    +  LQ  +    AL         + L++K  +++ + ++L +E++ 
Sbjct: 1080 ---LNEKLKKKEFEMSNLQGKIEDEQAL--------AIQLQKKIKELQARIEELEEEIE- 1127

Query: 169  IMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKER----IQDYEDILYKVVQFHQVKEEL 224
                  E   R    K++S   ++L    ++ +E         E    +  +F +++ +L
Sbjct: 1128 -----AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL 1182

Query: 225  GRLIKSREL-------EFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDII 277
                   E        +  +   ELG+  D    ++   EK+     +    L+  ++ +
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETV 1242

Query: 278  SSVQ----------RPHCSNVSAKNLQQQLELLEEDSMKWRAKAE--EYGRTLSRSVEYC 325
            S  +              S +  K  +QQ  + E  + K R   E  E+ R L    E  
Sbjct: 1243 SKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLD---EKD 1299

Query: 326  AMRDEINELKDSF-KDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQV-DMYAEKMQA-- 381
            AM  +++  K +F + I++    L+     K+  +  L++ ++    + + Y E+ +A  
Sbjct: 1300 AMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA 1359

Query: 382  -LKRKMEKVSNKTSDSFLNYPSDKVN----------VLLEVMKDLQKHVDDFDKVVTDYK 430
             L+R M K +++ +     Y +D +            L + ++D ++HV+  +      +
Sbjct: 1360 ELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLE 1419

Query: 431  KNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKIL---HQQFNKFIAPS 487
            K     +  Q  +E+     E ++A  + + K     K +   K+L    Q++ +  A  
Sbjct: 1420 KT---KQRLQNEVEDLMIDVERSNAACIALDK-----KQRNFDKVLAEWKQKYEETQAEL 1471

Query: 488  VPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTE 538
               Q+E    +T+L +     EE   ++E +  ++K + + +++L E + E
Sbjct: 1472 EASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAE 1522



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 129/633 (20%), Positives = 265/633 (41%), Gaps = 115/633 (18%)

Query: 19   QDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKNTM 78
            Q  A+A   +D+ E+  QL   K      L  +   +   A++ E  ++  E+   K  +
Sbjct: 894  QVQAEADALADAEERCDQLIKTKI----QLEAKIKEVTERAEDEE--EINAELTAKKRKL 947

Query: 79   ENQKAERE------ELSLLRLAWQLKATESKPGK--QQWAAFKEQLKKTSHNLKLLQEAL 130
            E++ +E +      EL+L ++  +  ATE+K     ++ A   E + K +   K LQEA 
Sbjct: 948  EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1007

Query: 131  MP-----------VSAL------------DLGGSLQ----FILDL--------------R 149
                         V+ L            DL GSL+      +DL              +
Sbjct: 1008 QQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQ 1067

Query: 150  QKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYED 209
            +   D +   QQLN++++    E   L G+    +  + QL+  I   ++ + RI++ E+
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKI---KELQARIEELEE 1124

Query: 210  ILYKVVQFHQVKEELGRLIKSRELEFV-EQPKELGDAHDVQIHLRCSQEKQARVDHLHRL 268
             + +  +  + K E  R   SRELE + E+ +E G A   QI +  +++++A    + R 
Sbjct: 1125 EI-EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEM--NKKREAEFQKMRRD 1181

Query: 269  ALSLGVD---IISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYC 325
                 +      +++++ H  +V+   L +Q++ L+    K   +  E            
Sbjct: 1182 LEESTLQHEATAAALRKKHADSVA--ELGEQIDSLQRVKQKLEKEKSE------------ 1227

Query: 326  AMRDEINELKDSFKDIKK-KFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKR 384
             ++ EIN+L  + + + K K N  K   T +++    L  +K + ++      ++ A K 
Sbjct: 1228 -LKMEINDLASNMETVSKAKANFEKMCRTLEDQ----LSEIKTKEEEQQRLINELSAQKA 1282

Query: 385  KMEKVSNKTS------DSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEH 438
            ++   S + S      D+ ++  S       + +++L++ +++  K  +     L    H
Sbjct: 1283 RLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARH 1342

Query: 439  FQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEA 498
              +++ E                +Y  E + K  ++    + N  +A      + R +  
Sbjct: 1343 DCDLLRE----------------QYEEEQEAKAELQRGMSKANSEVA------QWRTKYE 1380

Query: 499  TDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDF 558
            TD  Q    LEE +K + + +   +E +E+V   C SL + +++L Q +V  +  ++E  
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRL-QNEVEDLMIDVERS 1439

Query: 559  HYDYIDLLKEPAKNKQTIFNEERNKGQVQVADL 591
            +   I L K+  +N   +  E + K +   A+L
Sbjct: 1440 NAACIALDKK-QRNFDKVLAEWKQKYEETQAEL 1471



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 88/496 (17%), Positives = 200/496 (40%), Gaps = 98/496 (19%)

Query: 106  KQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDE 165
            K+++   KE+L KT    K L+E +               + L Q+ ND++ Q Q   D 
Sbjct: 857  KEEFEKTKEELAKTEAKRKELEEKM---------------VTLMQEKNDLQLQVQAEADA 901

Query: 166  VQYIMKESEELTGRGAPVKEKSQQL-KDLIHFHQKQKERIQDYEDILYKVVQFHQVKEEL 224
            +              A  +E+  QL K  I    K KE  +  ED           +EE+
Sbjct: 902  L--------------ADAEERCDQLIKTKIQLEAKIKEVTERAED-----------EEEI 936

Query: 225  GRLIKSRELEFVEQPKEL-GDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRP 283
               + +++ +  ++  EL  D  D+++ L       A+V+                 +  
Sbjct: 937  NAELTAKKRKLEDECSELKKDIDDLELTL-------AKVE-----------------KEK 972

Query: 284  HCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAM-RDEINELKDSFKDIK 342
            H +    KNL +++  L+E   K   + +       ++++   M  D++N L  +   ++
Sbjct: 973  HATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLE 1032

Query: 343  KKFNNLKFNYTKKNEKSRNLKALKYQI-------QQVDMYAEK-MQALKRKMEKVSNKTS 394
            ++ ++L+ +  ++ +   +L+  K ++       Q+  M  E   Q L  K++K   + S
Sbjct: 1033 QQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMS 1092

Query: 395  DSFLNYPSDKVNV--LLEVMKDLQKHVDDFDKVV--------TDYKKNLDLTEHFQEVIE 444
            +       ++     L + +K+LQ  +++ ++ +           K+  DL+   +E+ E
Sbjct: 1093 NLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE 1152

Query: 445  ECHFWYEDASATVVRVG-KYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQ 503
                  E   AT  ++      E + ++  + L +   +  A +   +++      +L +
Sbjct: 1153 RLE---EAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209

Query: 504  HLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYI 563
             +  L+  ++ +EK  ++ K  +  +    E++++ +   +     KM   LE    D +
Sbjct: 1210 QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFE-----KMCRTLE----DQL 1260

Query: 564  DLLKEPAKNKQTIFNE 579
              +K   + +Q + NE
Sbjct: 1261 SEIKTKEEEQQRLINE 1276



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 86/391 (21%), Positives = 152/391 (38%), Gaps = 65/391 (16%)

Query: 198  QKQKERIQ-DYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQ 256
            +K K+R+Q + ED++  V + +     L +  ++ +    E  ++     + Q  L  SQ
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKY---EETQAELEASQ 1475

Query: 257  -EKQARVDHLHRL--ALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEE 313
             E ++    L ++  A    +D + +++R +      KNLQQ++  L E   +      E
Sbjct: 1476 KESRSLSTELFKVKNAYEESLDHLETLKREN------KNLQQEISDLTEQIAEGGKHIHE 1529

Query: 314  YGRTLSR-SVEYCAMRDEINELKDSFKD-------IKKKFNNLKFNYTKK-NEKSRNLKA 364
              +   +   E   ++  + E + S +        I+ + N +K    +K  EK   L  
Sbjct: 1530 LEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQ 1589

Query: 365  LKYQIQQVDMYAEKMQA--------------LKRKMEKVSNKTSDSFLNYPSDKVNVLLE 410
            LK    +V    E MQ+              +K+KME   N+     LN+ + +    L 
Sbjct: 1590 LKRNHLRV---VESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQ-LNHANRQAAEALR 1645

Query: 411  -------VMKDLQKHVDDFDKVVTDYKKNLDLTEH----FQEVIEECHFWYEDASATVVR 459
                   ++KD Q H+DD  +   D K+ L + E      Q  +EE       AS     
Sbjct: 1646 NLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELR-----ASLERTE 1700

Query: 460  VGKYSTE---CKTKEAVKILHQQFNKFIAPSVPQQEERIQ---EATDLAQHLYGLEEGQK 513
             G+   E       E V++LH Q    I      + +  Q   E  D+ Q     EE  K
Sbjct: 1701 RGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAK 1760

Query: 514  YIEKIVTKHKEVLESVTELCESLTELEEKLK 544
               K +T    + E + +  ++   LE   K
Sbjct: 1761 ---KAITDAAMMAEELKKEQDTSAHLERMKK 1788


>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
          Length = 1780

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 89/440 (20%), Positives = 184/440 (41%), Gaps = 95/440 (21%)

Query: 10   YETEIPQKEQD-DAKAKHCSDSAEKQWQLFLKKSFITQ------DLGLEFLNLINMAKEN 62
            Y+ +I + E   + +   CS SA+ +  +  K+S I +      +      + +   K+ 
Sbjct: 1119 YKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDL 1178

Query: 63   EI--LDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTS 120
             +  L +K E+  + N +++ K       LL    QLK  E +  +Q+    KE+L  +S
Sbjct: 1179 NVKELKLKEEITQLTNNLQDMK------HLL----QLKEEEEETNRQETEKLKEELSASS 1228

Query: 121  HNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRG 180
               + L+         DL    +   DL++K  D K Q +Q+  EV  +  E + L  + 
Sbjct: 1229 ARTQNLK--------ADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKI 1280

Query: 181  APVKEKS--------------QQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGR 226
              +++K               QQLK+ ++ +QK +E IQ YE     +    ++ E++  
Sbjct: 1281 NELEKKKNQCSQELDMKQRTIQQLKEQLN-NQKVEEAIQQYERACKDLNVKEKIIEDMRM 1339

Query: 227  LIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCS 286
             ++ +E   VEQ + L                +A+++ + RLA  L         +  C+
Sbjct: 1340 TLEEQEQTQVEQDQVL----------------EAKLEEVERLATEL------EKWKEKCN 1377

Query: 287  NVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFN 346
            ++  KN Q+  +  E ++       +  G+  +       ++DE+ E +  +   +KK+ 
Sbjct: 1378 DLETKNNQRSNKEHENNT-------DVLGKLTN-------LQDELQESEQKYNADRKKWL 1423

Query: 347  NLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVN 406
              K     + +++ N++      +++  YAE  +   ++  ++   T+            
Sbjct: 1424 EEKMMLITQAKEAENIRN-----KEMKKYAEDRERFFKQQNEMEILTAQ----------- 1467

Query: 407  VLLEVMKDLQKHVDDFDKVV 426
             L E   DLQK  ++ D++V
Sbjct: 1468 -LTEKDSDLQKWREERDQLV 1486



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 89/448 (19%), Positives = 186/448 (41%), Gaps = 60/448 (13%)

Query: 158  QFQQLNDEVQYIMKESEELTGRGAPVKEKSQQ-----LKDLIHFHQKQKERIQDYEDIL- 211
            Q ++L  +++ +  E +        +KEK  +     LK+     Q+ KE +Q+    L 
Sbjct: 1037 QIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLD 1096

Query: 212  ---YKVVQFHQVKEELGRLI-----KSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVD 263
                 VV+  +   EL + +     K +ELE + + +++  +H  ++  +   EK++ + 
Sbjct: 1097 VQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLE-QDILEKESIIL 1155

Query: 264  HLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEED--SMKWRAKAEEYGRTLSRS 321
             L R        +  SV+     NV    L++++  L  +   MK   + +E     +R 
Sbjct: 1156 KLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQ 1215

Query: 322  VEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQA 381
                    E  +LK+       +  NLK +  +K E   +LK             EK+  
Sbjct: 1216 --------ETEKLKEELSASSARTQNLKADLQRKEEDYADLK-------------EKLTD 1254

Query: 382  LKRKMEKVSNKTS-----DSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLT 436
             K+++++V  + S     D  L     K+N L +      + +D   + +   K+ L+  
Sbjct: 1255 AKKQIKQVQKEVSVMRDEDKLLRI---KINELEKKKNQCSQELDMKQRTIQQLKEQLN-- 1309

Query: 437  EHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQ 496
                + +EE    YE A   +      + + K  E +++  ++  +         E +++
Sbjct: 1310 ---NQKVEEAIQQYERACKDL------NVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLE 1360

Query: 497  EATDLAQHLYGLEEGQKYIE-KIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNL 555
            E   LA  L   +E    +E K   +  +  E+ T++   LT L+++L++ +  K N + 
Sbjct: 1361 EVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESE-QKYNADR 1419

Query: 556  EDFHYDYIDLLKEPAKNKQTIFNEERNK 583
            + +  + + L+ + AK  + I N+E  K
Sbjct: 1420 KKWLEEKMMLITQ-AKEAENIRNKEMKK 1446



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 52/264 (19%), Positives = 119/264 (45%), Gaps = 53/264 (20%)

Query: 291 KNLQQQLELLEE-DSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLK 349
           ++L ++LE  EE  +++ +   E+  +TL  +  + +  +E  +L D  +D+KKK  N  
Sbjct: 533 EDLVEELENAEETQNVETKLLDEDLDKTLEENKAFIS-HEEKRKLLDLIEDLKKKLIN-- 589

Query: 350 FNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLL 409
                  EK   L  L+++I+                E+V+ + +  +    +D    LL
Sbjct: 590 -------EKKEKL-TLEFKIR----------------EEVTQEFTQYWAQREADFKETLL 625

Query: 410 EVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKT 469
           +  + L+++ +          + L +   F++++ +C    E+A+  +      +T+ +T
Sbjct: 626 QEREILEENAE----------RRLAI---FKDLVGKCDT-REEAAKDIC-----ATKVET 666

Query: 470 KEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVL--- 526
           +EA   L  +FN+  A     + E I+   +L +      E    I+++ T +K+++   
Sbjct: 667 EEATACLELKFNQIKAELAKTKGELIKTKEELKKR---ENESDSLIQELETSNKKIITQN 723

Query: 527 ESVTELCESLTELEEKLKQGDVLK 550
           + + EL   + + E+ + +   LK
Sbjct: 724 QRIKELINIIDQKEDTINEFQNLK 747


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 128/638 (20%), Positives = 265/638 (41%), Gaps = 109/638 (17%)

Query: 13   EIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVY 72
            E+  +E++ A+ K       ++ Q+ LKK        + FL   N+    EI   + +  
Sbjct: 1341 EVMPREEEQAQKKARDMLGLEETQVILKKG-----KKVIFLEPGNVTMGKEISKKEEKKT 1395

Query: 73   LMKNTMENQKAEREELSLLRLAWQLKATESKPGKQ--QWAAFKEQLKKTSHNLKLLQEAL 130
              K+  + +KA ++E  + ++  ++   E    ++  + A  +E++ K    L +++   
Sbjct: 1396 FQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERTP 1455

Query: 131  MPVSALDLGGSLQFIL-DLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRG---APVKEK 186
                        + +  + R+ W   K ++++       +++E E+L   G   +P +E 
Sbjct: 1456 SWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKR------LLQEEEKLHQAGEKLSPEEEM 1509

Query: 187  SQQLKDLIHFHQKQKERIQDYEDIL--------YKVVQFHQVKEELGRLIKSRELEFVEQ 238
             Q+ K L     K +E  Q +E++L        YK  +   ++EE+ R  + +E +  E+
Sbjct: 1510 LQEDKKL-----KWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEE 1564

Query: 239  PKELGDAHD-VQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQL 297
             + + + H   +IH + ++ ++ R     +LA                     K  Q++ 
Sbjct: 1565 QRHIQEEHKWARIHRKRARAEKKRAQEERKLAQE-----------------EEKLAQEER 1607

Query: 298  ELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNE 357
            +L +E+            R L+++  Y  +  +  E+  +    + KF   +    ++ E
Sbjct: 1608 QLAQEE------------RKLAQA--YVKITQDDREMAQA----EGKFAQKEETLAQRGE 1649

Query: 358  KSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQK 417
            K           Q+ +  A+K + L +K EKV+ +         + K   L EV   L +
Sbjct: 1650 KLS---------QEAEKLAQKRKKLAKKWEKVAREEEKL-----AKKGGKLAEVKNILAQ 1695

Query: 418  HVDDFDKVVTDYKKNLDLTE-HFQEVIEECHFWYEDASATVVRV----GKYSTECK---- 468
             V++    +   ++NLD  E    + +EE  +  E+ S     +    GK   E K    
Sbjct: 1696 KVEE----LPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAE 1751

Query: 469  TKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLES 528
             +EA+    ++ ++       ++E  IQE   LAQH   + E +   E++  K ++++E 
Sbjct: 1752 EEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEE---ERLGRKREQLIEK 1808

Query: 529  VTELCES----LTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQT-IFNEER-- 581
              +L +     +  +EE  K   +L    NL     +     ++ A+ K+  ++N+ER  
Sbjct: 1809 KMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLT 1868

Query: 582  --NKGQVQVADLLG----INGTGEERLPQDLKVSTDKE 613
               K  VQV + LG    I    EE+L Q+ +    K+
Sbjct: 1869 HSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKK 1906



 Score = 38.5 bits (88), Expect = 0.027
 Identities = 110/563 (19%), Positives = 230/563 (40%), Gaps = 56/563 (9%)

Query: 61   ENEILDVKNEVYLMKNTMEN--QKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKK 118
            + +++ VKN++ +    +    +K  +E+ ++++   +L  TE K  + + +  K+Q K 
Sbjct: 1871 KKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKL 1930

Query: 119  TSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTG 178
                +KL  E  M      L G     LD+ ++   +  + ++L +E   +++  E L+ 
Sbjct: 1931 AQEKMKLALEKAMVQGKKRLRGE----LDIAKEEKALNLEMKRLAEEKMRLVEGKETLSK 1986

Query: 179  RGAPVKEKSQQL----KDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSR-EL 233
               P   + +++    ++L       +E+I  +ED   +++   + +   G+L  +R + 
Sbjct: 1987 GETPETSRQRKMTQVEQELFERKLSLEEKILLHED---RILAMEESEIAKGKLEFTRGQR 2043

Query: 234  EFVEQPKELGDAHDVQIHLRCSQEKQ--------ARVDHLHRLALSLGVDIISSVQRPHC 285
             FV+  ++L  A    I  R S  K+          +  L R    L  + I   +    
Sbjct: 2044 IFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRA 2103

Query: 286  SNVSAKNL---QQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCA--MRDEINELKDSFKD 340
              V  + L   Q +L++ E D  + R++  +  + L+R     A  MR  IN+ ++   +
Sbjct: 2104 LFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINK-EEKMTE 2162

Query: 341  IKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNY 400
             + K           +E+   ++      ++V  +  K +  KRK  K  +K  + F + 
Sbjct: 2163 EESKLARKHSEVILDDEEEGGIEE-----EEVIPFL-KRRWRKRKEAKRGDKPKEKF-SS 2215

Query: 401  PSDKVNVLLEVMKDLQKHVDDFDKVVT-----DYKKNLDLTEHFQEVIEECHFWYEDASA 455
              D+V       ++++  +D+ +K  +     + ++  +     +EV EE     E+   
Sbjct: 2216 QVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEG 2275

Query: 456  TVVRVGKYSTECKTKEAVKILHQQFNK---FIAPSVPQQEERIQEATDLAQHLYGLEEGQ 512
               +V K   E K K+  K   +   K   F        EE  +  +D  +     EE  
Sbjct: 2276 EEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEE-----EEES 2330

Query: 513  KYIEKIVTKHKEVLESVTELCESLTELEEKLKQG-----DVLKMNPNLEDFHYDYIDLLK 567
              +E+ V + KE+L+   +    L E   K  +G      +L+  P+ +      + +LK
Sbjct: 2331 CSLEEEVDREKEILKKEKQF--KLQEQRRKSLRGRERVLSILRGVPHGKG-RAIRLGVLK 2387

Query: 568  EPAKNKQTIFNEERNKGQVQVAD 590
             P K   +   E + K  V V +
Sbjct: 2388 SPLKKLMSTALEMKEKTPVPVPE 2410


>gi|118498368 kinectin 1 isoform c [Homo sapiens]
          Length = 1300

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 108/513 (21%), Positives = 205/513 (39%), Gaps = 84/513 (16%)

Query: 17   KEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKN 76
            KE  D KAK     +       LKK    +D  ++ +  +    E E+L V N+   +++
Sbjct: 777  KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL---LEAELLKVANKEKTVQD 833

Query: 77   TMENQKAEREELSLLRL--AWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVS 134
              +  KA +EE+  ++L  A QL  T      Q     KE+   T        +A++   
Sbjct: 834  LKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNT-------MKAVLEEK 886

Query: 135  ALDLGGSLQFILDLRQKWNDMKPQFQQLN-------------DEVQYIMKESEE------ 175
              DL  + +++ DL+++   +K   Q++              +E++ ++KE E       
Sbjct: 887  EKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE 946

Query: 176  --LTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSREL 233
              L  R + +  K+Q L+D+   ++  K +I+  +   Y+        EEL ++I  RE 
Sbjct: 947  AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 1006

Query: 234  EFVEQPKELGDAHDVQIHLR-CSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVS--- 289
            E      EL    D   H R  + E+Q +V+ +   A  +   +   V  P  SN+S   
Sbjct: 1007 EISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVP--SNLSYGE 1064

Query: 290  ---------------------AKNLQQQLE-------LLEEDSMKWR---AKAEEYGRTL 318
                                  K L+ +L+       LL+ +  K++   A+ E   + L
Sbjct: 1065 WLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKL 1124

Query: 319  SRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEK 378
             RSVE      E N+ K    +  K    ++ ++T   ++   L+ L+ + + ++    +
Sbjct: 1125 QRSVE-----QEENKWKVKVDESHKTIKQMQSSFTSSEQE---LERLRSENKDIENLRRE 1176

Query: 379  MQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEH 438
             + L+ ++EK   + S +++    +    L E +  L+   ++  KV  D  K     E 
Sbjct: 1177 REHLEMELEKAEMERS-TYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLEL 1235

Query: 439  FQEVIEECHFWYEDASATVVRVGKYSTECKTKE 471
             Q  I +          TV+     S E ++ E
Sbjct: 1236 IQSKIVKA-----AGDTTVIENSDVSPETESSE 1263



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 115/562 (20%), Positives = 221/562 (39%), Gaps = 86/562 (15%)

Query: 59   AKENEILDVKNEVYLMKNTME-------NQKAEREELSLLRLAWQLKATESKPGKQQWAA 111
            +KE E+ D++N  +L+K  ++        Q A   EL  ++ +  +K  + +  ++Q   
Sbjct: 632  SKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ--- 688

Query: 112  FKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMK 171
             + ++       K+L +      AL         L   Q   D+  Q ++   E    +K
Sbjct: 689  LQHEISNKMEEFKILND---QNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 745

Query: 172  ESEELTGRG-APVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKS 230
              EEL   G   V  K ++L  +   +    + +QD +      V F  + EEL ++I  
Sbjct: 746  TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805

Query: 231  RELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSA 290
            ++ + ++  +EL +A  +++       K+  V  L +   +L  + I +VQ      +S 
Sbjct: 806  KDGK-IKSVEELLEAELLKV-----ANKEKTVQDLKQEIKALKEE-IGNVQLEKAQQLSI 858

Query: 291  KNLQQQLELL----EEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINE-LKDSFKDIKK-- 343
             +  Q+L+ L    EE     +A  EE  + L+ + ++     E NE LK   +++ +  
Sbjct: 859  TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 918

Query: 344  --------KFNNLKFNYTKKNEKSRNLKA--------LKYQIQQVDMYAEKMQALKRKME 387
                    +F  L+    +K  + + L+A        L  + Q +    ++ +  K ++E
Sbjct: 919  LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978

Query: 388  KVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECH 447
            ++  +      ++P  +   LL+V+ + +K +      +   K   D  EH ++   E  
Sbjct: 979  QLKQQNYQQASSFPPHE--ELLKVISEREKEISGLWNELDSLK---DAVEHQRKKNNE-- 1031

Query: 448  FWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYG 507
                          +   E    EA ++L + F K   PS               + L+G
Sbjct: 1032 -------------RQQQVEAVELEAKEVLKKLFPKVSVPS----------NLSYGEWLHG 1068

Query: 508  LEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLK 567
             E+          K KE +   T   E +  LE KLK+ D +     LE   Y  +    
Sbjct: 1069 FEK----------KAKECMAG-TSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET 1117

Query: 568  EPAKNK-QTIFNEERNKGQVQV 588
            E    K Q    +E NK +V+V
Sbjct: 1118 EGILQKLQRSVEQEENKWKVKV 1139


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 114/572 (19%), Positives = 224/572 (39%), Gaps = 100/572 (17%)

Query: 59   AKENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKK 118
            +KE E+ D++N  +L+       KAE ++L  L       A E      +    ++ +  
Sbjct: 632  SKEEELKDIQNMNFLL-------KAEVQKLQAL-------ANEQAAAAHELEKMQQSVYV 677

Query: 119  TSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTG 178
                ++LL+E                   L+ + ++   +F+ LND+ + +  E ++L  
Sbjct: 678  KDDKIRLLEE------------------QLQHEISNKMEEFKILNDQNKALKSEVQKLQT 719

Query: 179  --RGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFV 236
                 P K+  +Q++  I   Q++ E+++  E++L   +     KEE    I++      
Sbjct: 720  LVSEQPNKDVVEQMEKCI---QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776

Query: 237  EQPKELGDAHDVQIHLRCSQEKQARVDH-----LHRLALSLGVDIISSVQRPHCSNVSAK 291
            ++ ++L    + Q+      E+  +V H     +  +   L  +++    +     +S  
Sbjct: 777  KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSIT 836

Query: 292  NLQQQLELL----EEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINE-LKDSFKDIKK--- 343
            +  Q+L+ L    EE     +A  EE  + L+ + ++     E NE LK   +++ +   
Sbjct: 837  SKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNL 896

Query: 344  -------KFNNLKFNYTKKNEKSRNLKA--------LKYQIQQVDMYAEKMQALKRKMEK 388
                   +F  L+    +K  + + L+A        L  + Q +    ++ +  K ++E+
Sbjct: 897  KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 956

Query: 389  VSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDF--------DKVVTDYKKNLDLTEHFQ 440
            +  +      ++P  +   LL+V+ + +K +           D V    KKN DL E   
Sbjct: 957  LKQQNYQQASSFPPHE--ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNW 1014

Query: 441  EVIE---ECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQE 497
            E +E         +D      +  +   E    EA ++L + F K   PS          
Sbjct: 1015 EAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPS---------- 1064

Query: 498  ATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLED 557
                 + L+G E+          K KE +   T   E +  LE KLK+ D +     LE 
Sbjct: 1065 NLSYGEWLHGFEK----------KAKECMAG-TSGSEEVKVLEHKLKEADEMHTLLQLEC 1113

Query: 558  FHYDYIDLLKEPAKNK-QTIFNEERNKGQVQV 588
              Y  +    E    K Q    +E NK +V+V
Sbjct: 1114 EKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1145



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 112/519 (21%), Positives = 205/519 (39%), Gaps = 97/519 (18%)

Query: 86   EELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNL--------KLLQEALMPVSALD 137
            E  SL +    LKA ++   +  +A+  E+LKK  H          +LL+  L+ V+  +
Sbjct: 771  ENSSLTKEVQDLKAKQND--QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKE 828

Query: 138  LGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFH 197
                L     +++  N +K + +Q+N     + ++ ++L   G       + L+DL   +
Sbjct: 829  KTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG-------KWLQDLQEEN 881

Query: 198  QKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQE 257
            +  K  +Q+        V  H +KE      +  ELE V                   +E
Sbjct: 882  ESLKAHVQE--------VAQHNLKEA-SSASQFEELEIV------------------LKE 914

Query: 258  KQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKA---EEY 314
            K+  +  L  +      D+ S  Q         K  + Q+E L++ + +  +     EE 
Sbjct: 915  KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEEL 974

Query: 315  GRTLS-RSVEYCAMRDEINELKDSFKDIKKKFNNLK---------FNYTKKNEKSRNLKA 364
             + +S R  E   + +E++ LKD+ +  +KK N+L+            T+K  + +  K 
Sbjct: 975  LKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKT 1034

Query: 365  LKYQIQQVD-MYAEKMQALKRKMEKVSNKTSDSFLNY----------------PSDKVNV 407
             K + QQV+ +  E  + LK+   KVS  ++ S+  +                 S++V V
Sbjct: 1035 SKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV 1094

Query: 408  LLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTEC 467
            L   +K+  +           YK  L  TE   + ++             V   +   + 
Sbjct: 1095 LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRS-----------VEQEENKWKV 1143

Query: 468  KTKEAVKILHQQFNKFIAPSVPQQEERIQ-EATDLAQHLYGLEEGQKYIEKIVTKHK--- 523
            K  E+ K + Q  + F   S  Q+ ER++ E  D+       E  +  +EK   +     
Sbjct: 1144 KVDESHKTIKQMQSSF--TSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYV 1201

Query: 524  -EVLESVTELCESLTEL-----EEKLKQGDVLKMNPNLE 556
             EV E   +L E+LT+L     E +   GD+ K   +LE
Sbjct: 1202 TEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLE 1240


>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
          Length = 1173

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 96/492 (19%), Positives = 196/492 (39%), Gaps = 69/492 (14%)

Query: 50  LEFLNLINMAKENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQW 109
           LE L  +   +  ++ + + E+  +K   E     R++++             K  + + 
Sbjct: 50  LETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 109

Query: 110 AAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYI 169
              K +LK+  HNL  + +    + ALD                  K Q ++ N E++  
Sbjct: 110 DPLKNRLKEIEHNLSKIMKLDNEIKALD----------------SRKKQMEKDNSELEEK 153

Query: 170 MKESEELTGRGAPVKEKSQQLKDLIHFHQK---QKERIQDYEDILYKVVQFHQVKEELG- 225
           M++  + T          +QL DL H HQ+   +KER         K+V  H+  E+L  
Sbjct: 154 MEKVFQGT---------DEQLNDLYHNHQRTVREKER---------KLVDCHRELEKLNK 195

Query: 226 --RLIKSRELEF-VEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQR 282
             RL+   + E  VEQ +    A   Q H+R      AR   +  LA  L +D     +R
Sbjct: 196 ESRLLNQEKSELLVEQGRLQLQADRHQEHIR------ARDSLIQSLATQLELD---GFER 246

Query: 283 PHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELK-DSFKDI 341
              S    KN  + +          R + E   +T ++ +   A ++ + + + D  +D 
Sbjct: 247 GPFSERQIKNFHKLV----------RERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDK 296

Query: 342 KKKFNNL-KFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNY 400
           K     + +      ++K   LK +KY++QQ++  ++++  L +++ K   + S +  N 
Sbjct: 297 KTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKN- 355

Query: 401 PSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRV 460
            S+   + +EV+  LQ    D D+ +    + ++   H      +     +D +    ++
Sbjct: 356 -SNVETLKMEVI-SLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQI 413

Query: 461 GKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATD----LAQHLYGLEEGQKYIE 516
            K  +    +    + +    K +   +  + + I +  D    L + L   E+ + +I 
Sbjct: 414 RKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHIN 473

Query: 517 KIVTKHKEVLES 528
             + + +E L S
Sbjct: 474 NELKRKEEQLSS 485



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 98/502 (19%), Positives = 202/502 (40%), Gaps = 98/502 (19%)

Query: 114  EQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKW-NDMKPQFQQLNDEVQYI--- 169
            ++LK T   LK  ++    +  L L    Q I+DL++K   +++ + Q +N ++Q +   
Sbjct: 571  DKLKSTESELKKKEKRRDEM--LGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKND 628

Query: 170  MKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIK 229
            ++E E L G   P +E ++     +   ++ +  ++D E       +  Q   +L  +  
Sbjct: 629  IEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER------KIAQQAAKLQGIDL 682

Query: 230  SRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVS 289
             R ++ V Q K               QEKQ      H+L      D +SS  +   +   
Sbjct: 683  DRTVQQVNQEK---------------QEKQ------HKL------DTVSS--KIELNRKL 713

Query: 290  AKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLK 349
             ++ Q+Q++ L+  + + +++  +    L R  +   + ++  EL               
Sbjct: 714  IQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQ---LEEQTVELS-------------- 756

Query: 350  FNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKM---EKVSNKTSDSFLNYPSDKVN 406
               T+     R +K  K Q+  ++   EK Q  K ++   +  SNK +   LN   +KV 
Sbjct: 757  ---TEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVK 813

Query: 407  VLLEVMKDLQKHVDDFDKVVTDYKKN------------LDLTEHFQEVIEECHFWYEDAS 454
             +   MKD++ ++ D      DYKK              +  +H +++ E+     +D  
Sbjct: 814  NIHGYMKDIENYIQDGK---DDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 870

Query: 455  ATVVR---------VGKYSTECKTKEAVKILH-QQFNKFIAPSVPQQEERIQEATDLAQH 504
               ++         + K + E K  E  +  H ++  +     +  + ++++E  D  + 
Sbjct: 871  TQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 930

Query: 505  LYGLEEGQK--YIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYD- 561
             + L  G++  Y E+I+   KE+ E          + EEK ++  ++     L +   D 
Sbjct: 931  NHNLALGRQKGYEEEIIHFKKELRE------PQFRDAEEKYREMMIVMRTTELVNKDLDI 984

Query: 562  YIDLLKEPAKNKQTIFNEERNK 583
            Y   L +      ++  EE NK
Sbjct: 985  YYKTLDQAIMKFHSMKMEEINK 1006



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 80/411 (19%), Positives = 171/411 (41%), Gaps = 69/411 (16%)

Query: 62   NEILDVKNEVYLMKNTMENQKA-------EREELSLL--------RLAWQLKATESKPGK 106
            N++ +V  ++  +KN +E Q+        E E   +         R   +LK  E K  +
Sbjct: 613  NKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQ 672

Query: 107  Q----QWAAFKEQLKKTSHNLKLLQEALMPVSA-LDLGGSL-----QFILDLRQKWNDMK 156
            Q    Q       +++ +   +  Q  L  VS+ ++L   L     + I  L+   N++K
Sbjct: 673  QAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELK 732

Query: 157  PQF----------QQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERI-- 204
             +           QQL ++   +  E + L       KE+   L+  +   Q++KE +  
Sbjct: 733  SEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELIN 792

Query: 205  ---------QD-YEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRC 254
                     QD   DI  KV   H   +++   I+  + ++ +Q +   + + V   L  
Sbjct: 793  KKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKET--ELNKVIAQLSE 850

Query: 255  SQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEY 314
             ++ + +++   RL +   +D     +R    N++ +   ++L+ +EE+    +   +E 
Sbjct: 851  CEKHKEKINEDMRL-MRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEER---KQHLKEM 906

Query: 315  GRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKS--RNLKALKY-QIQQ 371
            G+     ++   M+ E  +L+++  +IK+  +NL     K  E+      K L+  Q + 
Sbjct: 907  GQ-----MQVLQMKSEHQKLEENIDNIKRN-HNLALGRQKGYEEEIIHFKKELREPQFRD 960

Query: 372  VDMYAEKMQALKRKMEKVSN------KTSD-SFLNYPSDKVNVLLEVMKDL 415
             +    +M  + R  E V+       KT D + + + S K+  + ++++DL
Sbjct: 961  AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDL 1011


>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
          Length = 1312

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 96/492 (19%), Positives = 196/492 (39%), Gaps = 69/492 (14%)

Query: 50  LEFLNLINMAKENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQW 109
           LE L  +   +  ++ + + E+  +K   E     R++++             K  + + 
Sbjct: 189 LETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEIVKSYENEL 248

Query: 110 AAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYI 169
              K +LK+  HNL  + +    + ALD                  K Q ++ N E++  
Sbjct: 249 DPLKNRLKEIEHNLSKIMKLDNEIKALD----------------SRKKQMEKDNSELEEK 292

Query: 170 MKESEELTGRGAPVKEKSQQLKDLIHFHQK---QKERIQDYEDILYKVVQFHQVKEELG- 225
           M++  + T          +QL DL H HQ+   +KER         K+V  H+  E+L  
Sbjct: 293 MEKVFQGT---------DEQLNDLYHNHQRTVREKER---------KLVDCHRELEKLNK 334

Query: 226 --RLIKSRELEF-VEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQR 282
             RL+   + E  VEQ +    A   Q H+R      AR   +  LA  L +D     +R
Sbjct: 335 ESRLLNQEKSELLVEQGRLQLQADRHQEHIR------ARDSLIQSLATQLELD---GFER 385

Query: 283 PHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELK-DSFKDI 341
              S    KN  + +          R + E   +T ++ +   A ++ + + + D  +D 
Sbjct: 386 GPFSERQIKNFHKLV----------RERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDK 435

Query: 342 KKKFNNL-KFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNY 400
           K     + +      ++K   LK +KY++QQ++  ++++  L +++ K   + S +  N 
Sbjct: 436 KTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKN- 494

Query: 401 PSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRV 460
            S+   + +EV+  LQ    D D+ +    + ++   H      +     +D +    ++
Sbjct: 495 -SNVETLKMEVI-SLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQI 552

Query: 461 GKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATD----LAQHLYGLEEGQKYIE 516
            K  +    +    + +    K +   +  + + I +  D    L + L   E+ + +I 
Sbjct: 553 RKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHIN 612

Query: 517 KIVTKHKEVLES 528
             + + +E L S
Sbjct: 613 NELKRKEEQLSS 624



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 98/502 (19%), Positives = 202/502 (40%), Gaps = 98/502 (19%)

Query: 114  EQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKW-NDMKPQFQQLNDEVQYI--- 169
            ++LK T   LK  ++    +  L L    Q I+DL++K   +++ + Q +N ++Q +   
Sbjct: 710  DKLKSTESELKKKEKRRDEM--LGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKND 767

Query: 170  MKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIK 229
            ++E E L G   P +E ++     +   ++ +  ++D E       +  Q   +L  +  
Sbjct: 768  IEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER------KIAQQAAKLQGIDL 821

Query: 230  SRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVS 289
             R ++ V Q K               QEKQ      H+L      D +SS  +   +   
Sbjct: 822  DRTVQQVNQEK---------------QEKQ------HKL------DTVSS--KIELNRKL 852

Query: 290  AKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLK 349
             ++ Q+Q++ L+  + + +++  +    L R  +   + ++  EL               
Sbjct: 853  IQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQ---LEEQTVELS-------------- 895

Query: 350  FNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKM---EKVSNKTSDSFLNYPSDKVN 406
               T+     R +K  K Q+  ++   EK Q  K ++   +  SNK +   LN   +KV 
Sbjct: 896  ---TEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVK 952

Query: 407  VLLEVMKDLQKHVDDFDKVVTDYKKN------------LDLTEHFQEVIEECHFWYEDAS 454
             +   MKD++ ++ D      DYKK              +  +H +++ E+     +D  
Sbjct: 953  NIHGYMKDIENYIQDGK---DDYKKQKETELNKVIAQLSECEKHKEKINEDMRLMRQDID 1009

Query: 455  ATVVR---------VGKYSTECKTKEAVKILH-QQFNKFIAPSVPQQEERIQEATDLAQH 504
               ++         + K + E K  E  +  H ++  +     +  + ++++E  D  + 
Sbjct: 1010 TQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKR 1069

Query: 505  LYGLEEGQK--YIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYD- 561
             + L  G++  Y E+I+   KE+ E          + EEK ++  ++     L +   D 
Sbjct: 1070 NHNLALGRQKGYEEEIIHFKKELRE------PQFRDAEEKYREMMIVMRTTELVNKDLDI 1123

Query: 562  YIDLLKEPAKNKQTIFNEERNK 583
            Y   L +      ++  EE NK
Sbjct: 1124 YYKTLDQAIMKFHSMKMEEINK 1145



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 80/411 (19%), Positives = 171/411 (41%), Gaps = 69/411 (16%)

Query: 62   NEILDVKNEVYLMKNTMENQKA-------EREELSLL--------RLAWQLKATESKPGK 106
            N++ +V  ++  +KN +E Q+        E E   +         R   +LK  E K  +
Sbjct: 752  NKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQ 811

Query: 107  Q----QWAAFKEQLKKTSHNLKLLQEALMPVSA-LDLGGSL-----QFILDLRQKWNDMK 156
            Q    Q       +++ +   +  Q  L  VS+ ++L   L     + I  L+   N++K
Sbjct: 812  QAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELK 871

Query: 157  PQF----------QQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERI-- 204
             +           QQL ++   +  E + L       KE+   L+  +   Q++KE +  
Sbjct: 872  SEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELIN 931

Query: 205  ---------QD-YEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRC 254
                     QD   DI  KV   H   +++   I+  + ++ +Q +   + + V   L  
Sbjct: 932  KKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKET--ELNKVIAQLSE 989

Query: 255  SQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEY 314
             ++ + +++   RL +   +D     +R    N++ +   ++L+ +EE+    +   +E 
Sbjct: 990  CEKHKEKINEDMRL-MRQDIDTQKIQERWLQDNLTLRKRNEELKEVEEER---KQHLKEM 1045

Query: 315  GRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKS--RNLKALKY-QIQQ 371
            G+     ++   M+ E  +L+++  +IK+  +NL     K  E+      K L+  Q + 
Sbjct: 1046 GQ-----MQVLQMKSEHQKLEENIDNIKRN-HNLALGRQKGYEEEIIHFKKELREPQFRD 1099

Query: 372  VDMYAEKMQALKRKMEKVSN------KTSD-SFLNYPSDKVNVLLEVMKDL 415
             +    +M  + R  E V+       KT D + + + S K+  + ++++DL
Sbjct: 1100 AEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDL 1150


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 111/576 (19%), Positives = 233/576 (40%), Gaps = 93/576 (16%)

Query: 19   QDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKNTM 78
            Q  A+A+  +D+ E+  QL   K      L  +   +   A++ E  ++  E+   K  +
Sbjct: 896  QVQAEAEGLADAEERCDQLIKTKI----QLEAKIKEVTERAEDEE--EINAELTAKKRKL 949

Query: 79   ENQKAERE------ELSLLRLAWQLKATESKPGK--QQWAAFKEQLKKTSHNLKLLQEAL 130
            E++ +E +      EL+L ++  +  ATE+K     ++ A   E + K +   K LQEA 
Sbjct: 950  EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1009

Query: 131  MPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQL 190
                              +Q  +D++ +  ++N   +  +K  +++      ++++ +  
Sbjct: 1010 ------------------QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051

Query: 191  KDLIHFHQKQKERIQ-DYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQ 249
             DL    ++ K +++ D +     ++     K++L   +K +E E      ++ D   + 
Sbjct: 1052 MDL----ERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG 1107

Query: 250  IHLRCS-QEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWR 308
            I L+   +E QAR++ L      +  +  S  +     +  ++ L++  E LEE      
Sbjct: 1108 IQLQKKIKELQARIEELEE---EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1164

Query: 309  AKAEEYGRTLSRSVEYCAMRDEINELK---------------DSFKDIKKKFNNLKFNYT 353
            A+ E       R  E+  MR ++ E                 DS  ++ ++ +NL+    
Sbjct: 1165 AQIE---MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ-RVK 1220

Query: 354  KKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDK------VNV 407
            +K EK ++   +K +I  +    E +   K  +EK+     D      S +      +N 
Sbjct: 1221 QKLEKEKS--EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278

Query: 408  LLEVMKDLQKHVDDFDKVVTDYKKNLDLTEH----FQEVIEECHFWYED------ASATV 457
            L      LQ    +F + + + +  +         F + IEE     E+      A A  
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338

Query: 458  VRVGK---------YSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGL 508
            ++  +         Y  E ++K  ++    + N  +A      + R +  TD  Q    L
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA------QWRTKYETDAIQRTEEL 1392

Query: 509  EEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLK 544
            EE +K + + +   +E +E+V   C SL + +++L+
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 106/542 (19%), Positives = 214/542 (39%), Gaps = 70/542 (12%)

Query: 113  KEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKE 172
            +EQ ++   +   LQ AL   +        ++  D  Q+  +++   ++L   +Q   + 
Sbjct: 1350 REQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEH 1409

Query: 173  SEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRE 232
             E +  + A +++  Q+L++             + ED++  V + +     L +  ++ +
Sbjct: 1410 VEAVNAKCASLEKTKQRLQN-------------EVEDLMLDVERTNAACAALDKKQRNFD 1456

Query: 233  LEFVEQPKELGDAHDVQIHLRCSQEKQARV--DHLHRL--ALSLGVDIISSVQRPHCSNV 288
                E  ++  + H     L  SQ K+AR     L ++  A    +D + +++R +    
Sbjct: 1457 KILAEWKQKCEETH---AELEASQ-KEARSLGTELFKIKNAYEESLDQLETLKREN---- 1508

Query: 289  SAKNLQQQLELLEEDSMKWRAKAEEYGRTLSR-SVEYCAMRDEINELKDSFKDIKKKFNN 347
              KNLQQ++  L E   +   +  E  +   +   E C ++  + E + S +  + K   
Sbjct: 1509 --KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1566

Query: 348  LKFNYTK-KNEKSRNLKALKYQIQQVDM----YAEKMQA--------------LKRKMEK 388
            ++    + K+E  R +     +I Q+        E MQ+              LK+KME 
Sbjct: 1567 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626

Query: 389  VSNKTSDSFLNYPSDKVNVLLE-------VMKDLQKHVDDFDKVVTDYKKNLDLTEH--- 438
              N+     LN+ +      L        ++KD Q H+DD  +   D K+ L + E    
Sbjct: 1627 DLNEMEIQ-LNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRAN 1685

Query: 439  -FQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQE 497
              Q  IEE     E    +  R           E V++LH Q    I       +++++ 
Sbjct: 1686 LLQAEIEELRATLEQTERS--RKIAEQELLDASERVQLLHTQNTSLI-----NTKKKLE- 1737

Query: 498  ATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLED 557
             TD++Q    +E+  +       K K+ +     + E L   +E+     + +M  N+E 
Sbjct: 1738 -TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK--KEQDTSAHLERMKKNMEQ 1794

Query: 558  FHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGTGEERLPQDLKVSTDKEGGVQ 617
               D    L E  +       ++  K + +V +L G   + ++R  + +K     E  V+
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVK 1854

Query: 618  DL 619
            +L
Sbjct: 1855 EL 1856


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 111/576 (19%), Positives = 233/576 (40%), Gaps = 93/576 (16%)

Query: 19   QDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKNTM 78
            Q  A+A+  +D+ E+  QL   K      L  +   +   A++ E  ++  E+   K  +
Sbjct: 896  QVQAEAEGLADAEERCDQLIKTKI----QLEAKIKEVTERAEDEE--EINAELTAKKRKL 949

Query: 79   ENQKAERE------ELSLLRLAWQLKATESKPGK--QQWAAFKEQLKKTSHNLKLLQEAL 130
            E++ +E +      EL+L ++  +  ATE+K     ++ A   E + K +   K LQEA 
Sbjct: 950  EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1009

Query: 131  MPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQL 190
                              +Q  +D++ +  ++N   +  +K  +++      ++++ +  
Sbjct: 1010 ------------------QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLR 1051

Query: 191  KDLIHFHQKQKERIQ-DYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQ 249
             DL    ++ K +++ D +     ++     K++L   +K +E E      ++ D   + 
Sbjct: 1052 MDL----ERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG 1107

Query: 250  IHLRCS-QEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWR 308
            I L+   +E QAR++ L      +  +  S  +     +  ++ L++  E LEE      
Sbjct: 1108 IQLQKKIKELQARIEELEE---EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1164

Query: 309  AKAEEYGRTLSRSVEYCAMRDEINELK---------------DSFKDIKKKFNNLKFNYT 353
            A+ E       R  E+  MR ++ E                 DS  ++ ++ +NL+    
Sbjct: 1165 AQIE---MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ-RVK 1220

Query: 354  KKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDK------VNV 407
            +K EK ++   +K +I  +    E +   K  +EK+     D      S +      +N 
Sbjct: 1221 QKLEKEKS--EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLIND 1278

Query: 408  LLEVMKDLQKHVDDFDKVVTDYKKNLDLTEH----FQEVIEECHFWYED------ASATV 457
            L      LQ    +F + + + +  +         F + IEE     E+      A A  
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHA 1338

Query: 458  VRVGK---------YSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGL 508
            ++  +         Y  E ++K  ++    + N  +A      + R +  TD  Q    L
Sbjct: 1339 LQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVA------QWRTKYETDAIQRTEEL 1392

Query: 509  EEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLK 544
            EE +K + + +   +E +E+V   C SL + +++L+
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 106/542 (19%), Positives = 214/542 (39%), Gaps = 70/542 (12%)

Query: 113  KEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKE 172
            +EQ ++   +   LQ AL   +        ++  D  Q+  +++   ++L   +Q   + 
Sbjct: 1350 REQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEH 1409

Query: 173  SEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRE 232
             E +  + A +++  Q+L++             + ED++  V + +     L +  ++ +
Sbjct: 1410 VEAVNAKCASLEKTKQRLQN-------------EVEDLMLDVERTNAACAALDKKQRNFD 1456

Query: 233  LEFVEQPKELGDAHDVQIHLRCSQEKQARV--DHLHRL--ALSLGVDIISSVQRPHCSNV 288
                E  ++  + H     L  SQ K+AR     L ++  A    +D + +++R +    
Sbjct: 1457 KILAEWKQKCEETH---AELEASQ-KEARSLGTELFKIKNAYEESLDQLETLKREN---- 1508

Query: 289  SAKNLQQQLELLEEDSMKWRAKAEEYGRTLSR-SVEYCAMRDEINELKDSFKDIKKKFNN 347
              KNLQQ++  L E   +   +  E  +   +   E C ++  + E + S +  + K   
Sbjct: 1509 --KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1566

Query: 348  LKFNYTK-KNEKSRNLKALKYQIQQVDM----YAEKMQA--------------LKRKMEK 388
            ++    + K+E  R +     +I Q+        E MQ+              LK+KME 
Sbjct: 1567 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626

Query: 389  VSNKTSDSFLNYPSDKVNVLLE-------VMKDLQKHVDDFDKVVTDYKKNLDLTEH--- 438
              N+     LN+ +      L        ++KD Q H+DD  +   D K+ L + E    
Sbjct: 1627 DLNEMEIQ-LNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRAN 1685

Query: 439  -FQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQE 497
              Q  IEE     E    +  R           E V++LH Q    I       +++++ 
Sbjct: 1686 LLQAEIEELRATLEQTERS--RKIAEQELLDASERVQLLHTQNTSLI-----NTKKKLE- 1737

Query: 498  ATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLED 557
             TD++Q    +E+  +       K K+ +     + E L   +E+     + +M  N+E 
Sbjct: 1738 -TDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELK--KEQDTSAHLERMKKNMEQ 1794

Query: 558  FHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGTGEERLPQDLKVSTDKEGGVQ 617
               D    L E  +       ++  K + +V +L G   + ++R  + +K     E  V+
Sbjct: 1795 TVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVK 1854

Query: 618  DL 619
            +L
Sbjct: 1855 EL 1856


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 119/619 (19%), Positives = 246/619 (39%), Gaps = 121/619 (19%)

Query: 2    QFQSLKEFYETEIP--QKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFL-NLINM 58
            Q + ++  Y+ EI   Q +QD  +A H  +    + +L   K    ++  LE + + ++ 
Sbjct: 616  QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM--KVIKEKENSLEAIRSKLDK 673

Query: 59   AKENEILDVKNEVYLMKNTMENQKAEREELSLLR------------LAWQLKATESK--- 103
            A++  ++++++ +    N ++  + + +EL +L+               QLKATE K   
Sbjct: 674  AEDQHLVEMEDTL----NKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD 729

Query: 104  ---------PGKQQWAAFKEQLKKTSHNLKLLQEALMPVSAL------DLGGSLQFILDL 148
                      GK +    ++QL+     +K L+      S+       +L G    + +L
Sbjct: 730  LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNL 789

Query: 149  RQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYE 208
            ++  +++    + L  E+Q + ++  E +     V+   Q+  + +H    QKE      
Sbjct: 790  QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH----QKEE----- 840

Query: 209  DILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRL 268
                   QF+ +  +L +L   RE           +  D++   R   EK  R + L + 
Sbjct: 841  -------QFNMLSSDLEKL---RE-----------NLADMEAKFR---EKDEREEQLIKA 876

Query: 269  ALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWR---AKAEEYGRTLSRSVEYC 325
               L  DI   ++    ++     +  +L L E D  + +    KA E    L +S+E  
Sbjct: 877  KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936

Query: 326  AMRDEINELKDSFK--DIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALK 383
             ++ E ++ + + K  + KK+      +  KK E S N                + Q LK
Sbjct: 937  TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN----------------QCQELK 980

Query: 384  RKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHV-DDFDKVVTDYKKNLDLTEHFQEV 442
             + E+ +++T                E++++LQK + D  DK+    ++N  L +  +E+
Sbjct: 981  ARYERATSETKTKHE-----------EILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029

Query: 443  IEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLA 502
             ++     + A A            +T E    + +Q  K    ++   E+  Q    L 
Sbjct: 1030 RKQA----DKAKAA-----------QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1074

Query: 503  QHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDY 562
              L  L+E      + + K KE+L    +  E   +  E LKQ    K +  L     + 
Sbjct: 1075 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK-SQQLSALQEEN 1133

Query: 563  IDLLKEPAKNKQTIFNEER 581
            + L +E  +++  + + ++
Sbjct: 1134 VKLAEELGRSRDEVTSHQK 1152



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 120/632 (18%), Positives = 260/632 (41%), Gaps = 75/632 (11%)

Query: 11   ETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKEN-EIL--DV 67
            ++ I + E+D   A    + AE + +L   K     D+ L  L  I+  +E  E+   D 
Sbjct: 463  KSRIMELEKD--LALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDH 520

Query: 68   KNEVYLMKNTM-ENQKAEREELSLLRLAWQLKATESKPGKQQW-----------AAFKEQ 115
            + E+  +K      ++  ++E+  L  A +  + E++  K +            A +K +
Sbjct: 521  QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK 580

Query: 116  LKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEE 175
            L+    + +   E L    +  LG       +L+ +   M+  +Q   + +Q     +++
Sbjct: 581  LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQ-----NQQ 635

Query: 176  LTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEE--LGRL----IK 229
             + R A  KE       L+   ++++  ++     L K    H V+ E  L +L    IK
Sbjct: 636  DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 695

Query: 230  SRELEFV-----EQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPH 284
             +ELE +     EQ K + +       L+ ++EK   +D L R A S G   +  +++  
Sbjct: 696  VKELEVLQAKCNEQTKVIDNFTS---QLKATEEKLLDLDAL-RKASSEGKSEMKKLRQ-- 749

Query: 285  CSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLS-RSVEYCAMRDEINELKDSFKDIKK 343
                  +  ++Q++ LE +     +KA    R L  R ++   +++ ++E+    + ++K
Sbjct: 750  ----QLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 805

Query: 344  KFNNLKFNYTKKNEKSRNL-KALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNY-- 400
            +   LK  + + +E++ ++ ++++  + ++    E+   L   +EK+    +D    +  
Sbjct: 806  ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 865

Query: 401  PSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNL----DLTEHFQEVIEECHFWYEDASAT 456
              ++   L++  + L+  + +  K+  D    L    D     +  +EE       A+  
Sbjct: 866  KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 925

Query: 457  VVRVGK------YSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEE 510
               + K         E   +EA K  H++  K +   +   E++++ + +  Q L    E
Sbjct: 926  ASFLQKSIEDMTVKAEQSQQEAAK-KHEEEKKELERKLSDLEKKMETSHNQCQELKARYE 984

Query: 511  GQKYIEKIVTKHKEVLESVT---------------ELCESLTELEEKLKQGDVLKMNPNL 555
              +   +  TKH+E+L+++                E    L ELEE  KQ D  K     
Sbjct: 985  --RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTA 1042

Query: 556  EDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQ 587
            ED       + KE  +   ++ + ++   ++Q
Sbjct: 1043 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1074



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 89/385 (23%), Positives = 151/385 (39%), Gaps = 57/385 (14%)

Query: 16   QKEQDDAKAKHCSDSAEKQWQLF-LKKSFIT-----QDLGLEFLNLINMAKENEILDVKN 69
            ++ Q +A  KH  +  E + +L  L+K   T     Q+L   +    +  K      ++N
Sbjct: 941  EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQN 1000

Query: 70   EVYLMKNTMENQKAEREELS-LLRLAWQLKATESKPGKQQWAA-----FKEQLKKTSHNL 123
                + +T +  K  REE S LL+   +L+    K    Q A       ++  K+ +  L
Sbjct: 1001 LQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETL 1060

Query: 124  KLLQEALMPVSAL--DLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGA 181
              L++     + L  +L    +  L   ++ N  K      N +++   KE E L    A
Sbjct: 1061 ASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAA 1120

Query: 182  PVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVE-QPK 240
               +KSQQL  L   + K  E +    D     V  HQ  EE   ++ ++ LE  + + K
Sbjct: 1121 ---QKSQQLSALQEENVKLAEELGRSRD----EVTSHQKLEEERSVLNNQLLEMKKRESK 1173

Query: 241  ELGDAHDVQIHLRCS--------QEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKN 292
             + DA + +  L+ S         EK A ++ L      L  +           N SAK+
Sbjct: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE-----------NASAKS 1222

Query: 293  LQQQLELLEEDSMKWRAKA-------EEYGRTLSRS---------VEYCAMRDEINELKD 336
            L   ++ LE D +K   K        +E  R LS S          +  A   +I+ L  
Sbjct: 1223 LHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNS 1282

Query: 337  SFKDIKKKFNNLKFNYTKKNEKSRN 361
               D+++K  +LK      +E + N
Sbjct: 1283 VIVDLQRKNQDLKMKVEMMSEAALN 1307


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 119/619 (19%), Positives = 246/619 (39%), Gaps = 121/619 (19%)

Query: 2    QFQSLKEFYETEIP--QKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFL-NLINM 58
            Q + ++  Y+ EI   Q +QD  +A H  +    + +L   K    ++  LE + + ++ 
Sbjct: 651  QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM--KVIKEKENSLEAIRSKLDK 708

Query: 59   AKENEILDVKNEVYLMKNTMENQKAEREELSLLR------------LAWQLKATESK--- 103
            A++  ++++++ +    N ++  + + +EL +L+               QLKATE K   
Sbjct: 709  AEDQHLVEMEDTL----NKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLD 764

Query: 104  ---------PGKQQWAAFKEQLKKTSHNLKLLQEALMPVSAL------DLGGSLQFILDL 148
                      GK +    ++QL+     +K L+      S+       +L G    + +L
Sbjct: 765  LDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNL 824

Query: 149  RQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYE 208
            ++  +++    + L  E+Q + ++  E +     V+   Q+  + +H    QKE      
Sbjct: 825  QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH----QKEE----- 875

Query: 209  DILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRL 268
                   QF+ +  +L +L   RE           +  D++   R   EK  R + L + 
Sbjct: 876  -------QFNMLSSDLEKL---RE-----------NLADMEAKFR---EKDEREEQLIKA 911

Query: 269  ALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWR---AKAEEYGRTLSRSVEYC 325
               L  DI   ++    ++     +  +L L E D  + +    KA E    L +S+E  
Sbjct: 912  KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 971

Query: 326  AMRDEINELKDSFK--DIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALK 383
             ++ E ++ + + K  + KK+      +  KK E S N                + Q LK
Sbjct: 972  TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHN----------------QCQELK 1015

Query: 384  RKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHV-DDFDKVVTDYKKNLDLTEHFQEV 442
             + E+ +++T                E++++LQK + D  DK+    ++N  L +  +E+
Sbjct: 1016 ARYERATSETKTKHE-----------EILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1064

Query: 443  IEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLA 502
             ++     + A A            +T E    + +Q  K    ++   E+  Q    L 
Sbjct: 1065 RKQA----DKAKAA-----------QTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1109

Query: 503  QHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDY 562
              L  L+E      + + K KE+L    +  E   +  E LKQ    K +  L     + 
Sbjct: 1110 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK-SQQLSALQEEN 1168

Query: 563  IDLLKEPAKNKQTIFNEER 581
            + L +E  +++  + + ++
Sbjct: 1169 VKLAEELGRSRDEVTSHQK 1187



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 120/632 (18%), Positives = 260/632 (41%), Gaps = 75/632 (11%)

Query: 11   ETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKEN-EIL--DV 67
            ++ I + E+D   A    + AE + +L   K     D+ L  L  I+  +E  E+   D 
Sbjct: 498  KSRIMELEKD--LALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDH 555

Query: 68   KNEVYLMKNTM-ENQKAEREELSLLRLAWQLKATESKPGKQQW-----------AAFKEQ 115
            + E+  +K      ++  ++E+  L  A +  + E++  K +            A +K +
Sbjct: 556  QREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK 615

Query: 116  LKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEE 175
            L+    + +   E L    +  LG       +L+ +   M+  +Q   + +Q     +++
Sbjct: 616  LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQ-----NQQ 670

Query: 176  LTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEE--LGRL----IK 229
             + R A  KE       L+   ++++  ++     L K    H V+ E  L +L    IK
Sbjct: 671  DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 730

Query: 230  SRELEFV-----EQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPH 284
             +ELE +     EQ K + +       L+ ++EK   +D L R A S G   +  +++  
Sbjct: 731  VKELEVLQAKCNEQTKVIDNFTS---QLKATEEKLLDLDAL-RKASSEGKSEMKKLRQ-- 784

Query: 285  CSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLS-RSVEYCAMRDEINELKDSFKDIKK 343
                  +  ++Q++ LE +     +KA    R L  R ++   +++ ++E+    + ++K
Sbjct: 785  ----QLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 840

Query: 344  KFNNLKFNYTKKNEKSRNL-KALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNY-- 400
            +   LK  + + +E++ ++ ++++  + ++    E+   L   +EK+    +D    +  
Sbjct: 841  ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900

Query: 401  PSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNL----DLTEHFQEVIEECHFWYEDASAT 456
              ++   L++  + L+  + +  K+  D    L    D     +  +EE       A+  
Sbjct: 901  KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960

Query: 457  VVRVGK------YSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEE 510
               + K         E   +EA K  H++  K +   +   E++++ + +  Q L    E
Sbjct: 961  ASFLQKSIEDMTVKAEQSQQEAAK-KHEEEKKELERKLSDLEKKMETSHNQCQELKARYE 1019

Query: 511  GQKYIEKIVTKHKEVLESVT---------------ELCESLTELEEKLKQGDVLKMNPNL 555
              +   +  TKH+E+L+++                E    L ELEE  KQ D  K     
Sbjct: 1020 --RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTA 1077

Query: 556  EDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQ 587
            ED       + KE  +   ++ + ++   ++Q
Sbjct: 1078 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1109



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 89/385 (23%), Positives = 151/385 (39%), Gaps = 57/385 (14%)

Query: 16   QKEQDDAKAKHCSDSAEKQWQLF-LKKSFIT-----QDLGLEFLNLINMAKENEILDVKN 69
            ++ Q +A  KH  +  E + +L  L+K   T     Q+L   +    +  K      ++N
Sbjct: 976  EQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQN 1035

Query: 70   EVYLMKNTMENQKAEREELS-LLRLAWQLKATESKPGKQQWAA-----FKEQLKKTSHNL 123
                + +T +  K  REE S LL+   +L+    K    Q A       ++  K+ +  L
Sbjct: 1036 LQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETL 1095

Query: 124  KLLQEALMPVSAL--DLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGA 181
              L++     + L  +L    +  L   ++ N  K      N +++   KE E L    A
Sbjct: 1096 ASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAA 1155

Query: 182  PVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVE-QPK 240
               +KSQQL  L   + K  E +    D     V  HQ  EE   ++ ++ LE  + + K
Sbjct: 1156 ---QKSQQLSALQEENVKLAEELGRSRD----EVTSHQKLEEERSVLNNQLLEMKKRESK 1208

Query: 241  ELGDAHDVQIHLRCS--------QEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKN 292
             + DA + +  L+ S         EK A ++ L      L  +           N SAK+
Sbjct: 1209 FIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE-----------NASAKS 1257

Query: 293  LQQQLELLEEDSMKWRAKA-------EEYGRTLSRS---------VEYCAMRDEINELKD 336
            L   ++ LE D +K   K        +E  R LS S          +  A   +I+ L  
Sbjct: 1258 LHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNS 1317

Query: 337  SFKDIKKKFNNLKFNYTKKNEKSRN 361
               D+++K  +LK      +E + N
Sbjct: 1318 VIVDLQRKNQDLKMKVEMMSEAALN 1342


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 126/590 (21%), Positives = 242/590 (41%), Gaps = 104/590 (17%)

Query: 59   AKENEILDVKNEVYLMKNTMENQKAEREELSLLR--LAWQLKA-----TESKPGKQQWAA 111
            AK+ E+L VK +   ++  +E  + + ++L   +  LA QL+A      E++  + + AA
Sbjct: 856  AKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAA 915

Query: 112  FKEQLKKTSHNL-----------KLLQ--EALMPVSALDLGGSLQFILDLRQKW------ 152
             K++L++  H+L           ++LQ  +  M     DL   L      RQK       
Sbjct: 916  KKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVT 975

Query: 153  -----NDMKPQFQQLNDEVQYIMKESEELTGR----GAPVKEKSQQLKDLIHFHQKQKER 203
                   M+ +   L D+    +KE + +  R     + + E+ ++ K+L     KQ+  
Sbjct: 976  AEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVM 1035

Query: 204  IQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKEL-GDAHDVQIHLRCSQEKQARV 262
            I D E+ L K  +  Q  E+  R +     +  +Q  EL     ++++ L   +E+    
Sbjct: 1036 ISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL--- 1092

Query: 263  DHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRA---KAEEYGRTLS 319
                + AL+ G D   ++ + +   V  + LQ Q+  L+ED    +A   KAE+  R LS
Sbjct: 1093 ----QGALARGDD--ETLHKNNALKV-VRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145

Query: 320  RSVEYCAMRDEINELKDS--------------FKDIKKKFNNLKFNYTKKNEKSRN---- 361
              +E  A++ E+ +  D+                ++KK       N+  + +  R     
Sbjct: 1146 EELE--ALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHAT 1203

Query: 362  -LKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEV-------MK 413
             L+ L  Q++Q   +   ++  K+ +E  + +         + +V VL +V        K
Sbjct: 1204 ALEELSEQLEQAKRFKANLEKNKQGLETDNKEL--------ACEVKVLQQVKAESEHKRK 1255

Query: 414  DLQKHVDDFD-KVVTDYKKNLDLTE---HFQEVIEECHFWYEDASATVVRVGK--YSTEC 467
             L   V +   KV    +  ++L E     Q  ++      E+A    ++  K   S E 
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315

Query: 468  KTKEAVKILHQQFNK--FIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIV------ 519
            + ++  ++L ++  +   ++  + Q EE   E   L +     EE +K +EK V      
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEE---EKNSLQEQQEEEEEARKNLEKQVLALQSQ 1372

Query: 520  -TKHKEVLESVTELCESLTELEEK-LKQGDVLKMNPNLEDFHYDYIDLLK 567
                K+ ++      ESL E ++K LK  + L      +   YD ++  K
Sbjct: 1373 LADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTK 1422



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 108/532 (20%), Positives = 209/532 (39%), Gaps = 44/532 (8%)

Query: 73   LMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMP 132
            L KN    +   +E    +++  Q+KA      K+  A  +E   K S   +L  E    
Sbjct: 1222 LEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK 1281

Query: 133  VSAL--DLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQL 190
             S L  +L      + +  +K          L  ++Q   +  +E T +   +  + +QL
Sbjct: 1282 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341

Query: 191  KDLIHFHQKQKERIQDYEDILYKVVQFHQ---------VKEELGRLIKSRELEFVEQPKE 241
            ++  +  Q+Q+E  ++    L K V   Q         V ++LG +    E +     K 
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK----KKL 1397

Query: 242  LGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSV-----QRPHCSNVSAKNLQQQ 296
            L DA  +   L   +EK    D L +    L  ++         QR   SN+  K  +  
Sbjct: 1398 LKDAEALSQRL---EEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD 1454

Query: 297  LELLEEDSMKWR-AKAEEYGRTLSRSVEYCAMR-----DEINELKDSFKDIKKKFN-NLK 349
              L EE S+  R A+  +     +R  E  A+      +E  E K+ F+   K+   +++
Sbjct: 1455 QLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADME 1514

Query: 350  FNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLL 409
               + K++  +N+  L+   + ++   E+M+    ++E     T D+ L    +   +  
Sbjct: 1515 DLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574

Query: 410  EVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKT 469
            +  +DLQ   +       + KK L L +  +E+  E     +  +  V    K   + K 
Sbjct: 1575 QFERDLQTRDEQ-----NEEKKRL-LIKQVRELEAELEDERKQRALAVASKKKMEIDLKD 1628

Query: 470  KEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESV 529
             EA     +  NK     V +Q  ++Q    +  +   LEE +   ++I  + KE  + +
Sbjct: 1629 LEA---QIEAANK-ARDEVIKQLRKLQ--AQMKDYQRELEEARASRDEIFAQSKESEKKL 1682

Query: 530  TELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEER 581
              L   + +L+E+L   +  +   + E    +  D +   A  K  + +E+R
Sbjct: 1683 KSLEAEILQLQEELASSE--RARRHAEQERDELADEITNSASGKSALLDEKR 1732


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 122/583 (20%), Positives = 226/583 (38%), Gaps = 77/583 (13%)

Query: 86   EELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALD---LGGSL 142
            +EL+ L +  Q K  ES     Q+   + QLK+     +L+   L P+S +D   L    
Sbjct: 2550 QELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLS-IDPNMLNTQR 2608

Query: 143  QFILDLRQKWNDMKPQFQQLNDEVQYIM-KESEELTGRGAPVKEKSQQLKDLIHFHQKQK 201
            Q +  L Q++   KPQ++QL    Q I+ +  E+ + RG   ++ +   +       +  
Sbjct: 2609 QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2668

Query: 202  ERIQDYEDILYKVVQFHQVKEELGRLIK------SRELEFVEQPKELGDAHDVQIHLRCS 255
            +R    +  + K  Q+  +   L   +       S  L     P  +     ++   +  
Sbjct: 2669 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN--QQLETAQKMK 2726

Query: 256  QEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYG 315
            QE Q     + ++A +L  D+ + V+  +        L +QLE + +       KAE + 
Sbjct: 2727 QEIQQEKKQI-KVAQALCEDLSALVKEEYLK----AELSRQLEGILKSFKDVEQKAENHV 2781

Query: 316  RTLSRSVEYCAMRDEINELKDSFK---DIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQV 372
            + L  +   CA   +  ++   F+   D KK+  N      K +  S  L  L+  I+  
Sbjct: 2782 QHLQSA---CASSHQFQQMSRDFQAWLDTKKEEQN------KSHPISAKLDVLESLIKDH 2832

Query: 373  DMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTD---- 428
              +++ + A     EK   +  +  L     +   L   +  ++ + D F+K V +    
Sbjct: 2833 KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENK 2892

Query: 429  YKKNLDLTEHFQEVIEECHFWYEDASATVVRV--------GKYSTECKTKEAVKILHQQF 480
             K++L+    ++E +E    W +     +  +        G+ S   K K   K + Q F
Sbjct: 2893 LKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI-AKLKSLQKEMDQHF 2951

Query: 481  ----------NKFIAPSVPQQEERIQEATDLAQHLYGLEE---GQKY-IEKIVTKHKEVL 526
                      N  ++     +E    E   L Q +  + E    +K+ +E +  K KE  
Sbjct: 2952 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 3011

Query: 527  ESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQV 586
            E   E    L   +E+L   D L      + +   Y+ +L+   K+ Q +      K QV
Sbjct: 3012 EVSKESKRQLQCAKEQLDIHDSL----GSQAYSNKYLTMLQTQQKSLQAL------KHQV 3061

Query: 587  QVADLLGINGTGEERLPQDLKVSTDKEGGVQDLLLPEDMLSGE 629
             +A          +RL QDL V      G  D+LL  + ++ E
Sbjct: 3062 DLA----------KRLAQDLVVEASDSKGTSDVLLQVETIAQE 3094



 Score = 37.0 bits (84), Expect = 0.080
 Identities = 102/517 (19%), Positives = 193/517 (37%), Gaps = 125/517 (24%)

Query: 62   NEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSH 121
            N +L   N+VY M +T        ++L  + L   LK T++           E L K  +
Sbjct: 1180 NVVLQNMNQVYSMSSTYI------DKLKTVNLV--LKNTQAA----------EALVKL-Y 1220

Query: 122  NLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGA 181
              KL +E  +     ++   +  +   R + ++ +  F  L DE+Q     S+E+     
Sbjct: 1221 ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEM----- 1275

Query: 182  PVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKE 241
                            +  KER  D++        +H  KE+  +L++  +   V+    
Sbjct: 1276 ---------------FKTYKERDLDFD--------WH--KEKADQLVERWQNVHVQIDNR 1310

Query: 242  LGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQR------PHCSNVSAKNLQQ 295
            L D   +   L+  ++    +D          +  + + QR      P  S   A  L Q
Sbjct: 1311 LRDLEGIGKSLKYYRDTYHPLDDW--------IQQVETTQRKIQENQPENSKTLATQLNQ 1362

Query: 296  QLELLEEDSMKW------RAKAEEYGRTLS----RSVEYCAMRDEINE-------LKDSF 338
            Q  L+ E  MK       +  AE+Y  T+     +++ Y AM D   +       ++ S 
Sbjct: 1363 QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSA 1422

Query: 339  KDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFL 398
              I ++F +L+  YT           +    Q +    + ++ L+ + + +  +  +   
Sbjct: 1423 DLIIQEFMDLRTRYTA---------LVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH-- 1471

Query: 399  NYPSDKVNVLLEVMKDLQKHVDDFDKVVTD--------YKKNLDLTEHFQEVIEECHFWY 450
                      +E  K+LQK V +  K + D        + K    +E      E+     
Sbjct: 1472 ----------VEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1521

Query: 451  EDASATVVRVGKYSTECKTKEA---VKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYG 507
            +     + + G   T+ +  E    VK L + +N   + S+ Q +E  Q + D+      
Sbjct: 1522 QTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQES-QTSGDV------ 1574

Query: 508  LEEGQKYIEKIVT-KHKEVLESVTELCESLTELEEKL 543
                 K  EKIV  + +E  E +  +C+ LT+ E +L
Sbjct: 1575 -----KVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1606



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 91/514 (17%), Positives = 190/514 (36%), Gaps = 93/514 (18%)

Query: 154  DMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQ-QLKDLIHFHQKQKERIQDYEDILY 212
            +  P    +  +++ + K+  +L  R    +E+ +  +K L  F+ K KE    +  +L 
Sbjct: 3186 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE----FSILLQ 3241

Query: 213  KVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSL 272
            K  +  + +  +G      E E + Q   +      +  +   Q KQ  V+ L       
Sbjct: 3242 KAEEHEESQGPVGM-----ETETINQQLNMFKVFQKE-EIEPLQGKQQDVNWL------- 3288

Query: 273  GVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCA-MRDEI 331
            G  +I S  +    + S + L+  L+ +         K  +    L  ++ +C   +D +
Sbjct: 3289 GQGLIQSAAK----STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3344

Query: 332  NELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQ-------VDMYAEKMQALKR 384
              L     D ++   N K         S   K +K QIQ+       +D     ++ +KR
Sbjct: 3345 ESLLSWMVDTEELVANQK-------PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKR 3397

Query: 385  KMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLT---EHFQE 441
            + EK++          P+DKV +L ++     +     +K  T  ++   ++   + F E
Sbjct: 3398 EGEKIATTAE------PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHE 3451

Query: 442  VIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQF-------NKFIAPSVP----- 489
             +E  + W       +V      T+    E     H+         NK +  +V      
Sbjct: 3452 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3511

Query: 490  ------QQEERIQEATDLAQHLYGLEEGQK------YIEKIVTKHKEVLESVTELCESLT 537
                  + ++ +Q   D +Q  Y +E  +K       +++ +   K   E   EL   L 
Sbjct: 3512 KVLSSREDKDMVQSKLDFSQVWY-IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLN 3570

Query: 538  ELEEKLK----------------------QGDVLKMNPNLEDFHYDYIDLLKEPAKNKQT 575
            E+ +KL                       Q D+L    N++    + ++LLK+   ++  
Sbjct: 3571 EVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL 3630

Query: 576  IFNEERNKGQVQVADLLGINGTGEERLPQDLKVS 609
            I  ++    + +  D+  ++    + L Q L+++
Sbjct: 3631 IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3664



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 98/544 (18%), Positives = 213/544 (39%), Gaps = 87/544 (15%)

Query: 86   EELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFI 145
            +E+ L+    ++    SK   Q ++   E L K    L++LQE ++    L      Q +
Sbjct: 3561 DEVELMNWLNEVHDKLSKLSVQDYST--EGLWKQQSELRVLQEDIL----LRKQNVDQAL 3614

Query: 146  LDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQ 205
            L      N ++   Q   DEV  I  + E +  R   + + S  +   +           
Sbjct: 3615 L------NGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL----------- 3657

Query: 206  DYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDV-QIHLRCSQEKQARVDH 264
              E  L    + H   EEL   +   E+E +    ++    +  Q  +R    K+ + + 
Sbjct: 3658 --EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR---PKELKKEA 3712

Query: 265  LHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRA-------KAEEYGRT 317
             +  AL   +D ++ V       V  +  +   +++ ED+ ++R        K EE    
Sbjct: 3713 KNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA 3769

Query: 318  LSRSVEYCAMRD-EINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYA 376
            + RS ++    D E++ + ++    +KK  +L     ++++ S  L+  K    ++  + 
Sbjct: 3770 ILRSQQFDQAADAELSWITET----EKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHK 3825

Query: 377  EKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLD-- 434
            + +  L +   K+    S+        K++ +L       K+ D   ++ ++    L+  
Sbjct: 3826 DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVL-------KNYDTICQINSERYLQLERA 3878

Query: 435  --LTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQE 492
              L   F E  EE   W  +  + + ++   + E +T    +  H+Q  + IA   P  +
Sbjct: 3879 QSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3938

Query: 493  ER-----------------IQEATDLAQHLYG-LEEGQKY----IEKIVTKHKEVLESVT 530
            +                  IQE    A  LY  ++E  K     +++ +++  +  + + 
Sbjct: 3939 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3998

Query: 531  ELCESLTELEEKLKQ-----GDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQ 585
            ++ ESL  + E+L+Q      +V K+   + +     +D+ K      Q ++   + +G+
Sbjct: 3999 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEK-----LQPLYETLKQRGE 4053

Query: 586  VQVA 589
              +A
Sbjct: 4054 EMIA 4057



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 44/220 (20%), Positives = 99/220 (45%), Gaps = 30/220 (13%)

Query: 329  DEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEK 388
            +E NEL+   K +++ +N L     K+ ++S+    +K + + V   AE+ Q  K K++ 
Sbjct: 1538 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIV---AERQQEYKEKLQG 1594

Query: 389  VSN---KTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEE 445
            + +   +T +  + +   +  ++ +   +L+K+    +++  D + +    +   EV++ 
Sbjct: 1595 ICDLLTQTENRLIGH--QEAFMIGDGTVELKKYQSKQEELQKDMQGS---AQALAEVVKN 1649

Query: 446  CHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFN-----------KFIAPSVPQQEER 494
               + ++    + +  K   E K  EA KI  +Q N           K +  ++ ++ E+
Sbjct: 1650 TENFLKENGEKLSQEDKALIEQKLNEA-KIKCEQLNLKAEQSKKELDKVVTTAIKEETEK 1708

Query: 495  I-------QEATDLAQHLYGLEEGQKYIEKIVTKHKEVLE 527
            +       +  T +   L  L    K  E+  TKHK+V+E
Sbjct: 1709 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE 1748



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 44/253 (17%), Positives = 96/253 (37%), Gaps = 46/253 (18%)

Query: 291  KNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDI--------- 341
            + L+++LE L++D      K EE+    + S     +R E+N +  +   +         
Sbjct: 1139 EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1198

Query: 342  KKKFNNLKFNYTK----------------------KNEKSRNLKALKYQIQQVDMYAEKM 379
            K K  NL    T+                      KN     +  LK    +VD   +  
Sbjct: 1199 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1258

Query: 380  QALKRKMEKVSNKTSDSFLNYP---------SDKVNVLLEVMKDLQKHVDDFDKVVTDYK 430
             AL+ +++K    + + F  Y           +K + L+E  +++   +D+  + +    
Sbjct: 1259 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1318

Query: 431  KNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQ 490
            K+L   +++++       W +    T  ++ +   E  +K     L+QQ  K +   +  
Sbjct: 1319 KSL---KYYRDTYHPLDDWIQQVETTQRKIQENQPE-NSKTLATQLNQQ--KMLVSEIEM 1372

Query: 491  QEERIQEATDLAQ 503
            ++ ++ E    A+
Sbjct: 1373 KQSKMDECQKYAE 1385



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 16/54 (29%), Positives = 32/54 (59%), Gaps = 3/54 (5%)

Query: 111  AFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLND 164
            + K  +K+T+  + ++Q +     A DLG SL+    L++KW+   P+ Q++N+
Sbjct: 2326 SLKSWIKETTKKVPIVQPSF---GAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2376


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 122/583 (20%), Positives = 226/583 (38%), Gaps = 77/583 (13%)

Query: 86   EELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALD---LGGSL 142
            +EL+ L +  Q K  ES     Q+   + QLK+     +L+   L P+S +D   L    
Sbjct: 2561 QELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLS-IDPNMLNTQR 2619

Query: 143  QFILDLRQKWNDMKPQFQQLNDEVQYIM-KESEELTGRGAPVKEKSQQLKDLIHFHQKQK 201
            Q +  L Q++   KPQ++QL    Q I+ +  E+ + RG   ++ +   +       +  
Sbjct: 2620 QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2679

Query: 202  ERIQDYEDILYKVVQFHQVKEELGRLIK------SRELEFVEQPKELGDAHDVQIHLRCS 255
            +R    +  + K  Q+  +   L   +       S  L     P  +     ++   +  
Sbjct: 2680 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN--QQLETAQKMK 2737

Query: 256  QEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYG 315
            QE Q     + ++A +L  D+ + V+  +        L +QLE + +       KAE + 
Sbjct: 2738 QEIQQEKKQI-KVAQALCEDLSALVKEEYLK----AELSRQLEGILKSFKDVEQKAENHV 2792

Query: 316  RTLSRSVEYCAMRDEINELKDSFK---DIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQV 372
            + L  +   CA   +  ++   F+   D KK+  N      K +  S  L  L+  I+  
Sbjct: 2793 QHLQSA---CASSHQFQQMSRDFQAWLDTKKEEQN------KSHPISAKLDVLESLIKDH 2843

Query: 373  DMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTD---- 428
              +++ + A     EK   +  +  L     +   L   +  ++ + D F+K V +    
Sbjct: 2844 KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENK 2903

Query: 429  YKKNLDLTEHFQEVIEECHFWYEDASATVVRV--------GKYSTECKTKEAVKILHQQF 480
             K++L+    ++E +E    W +     +  +        G+ S   K K   K + Q F
Sbjct: 2904 LKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI-AKLKSLQKEMDQHF 2962

Query: 481  ----------NKFIAPSVPQQEERIQEATDLAQHLYGLEE---GQKY-IEKIVTKHKEVL 526
                      N  ++     +E    E   L Q +  + E    +K+ +E +  K KE  
Sbjct: 2963 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 3022

Query: 527  ESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQV 586
            E   E    L   +E+L   D L      + +   Y+ +L+   K+ Q +      K QV
Sbjct: 3023 EVSKESKRQLQCAKEQLDIHDSL----GSQAYSNKYLTMLQTQQKSLQAL------KHQV 3072

Query: 587  QVADLLGINGTGEERLPQDLKVSTDKEGGVQDLLLPEDMLSGE 629
             +A          +RL QDL V      G  D+LL  + ++ E
Sbjct: 3073 DLA----------KRLAQDLVVEASDSKGTSDVLLQVETIAQE 3105



 Score = 37.0 bits (84), Expect = 0.080
 Identities = 102/517 (19%), Positives = 193/517 (37%), Gaps = 125/517 (24%)

Query: 62   NEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSH 121
            N +L   N+VY M +T        ++L  + L   LK T++           E L K  +
Sbjct: 1191 NVVLQNMNQVYSMSSTYI------DKLKTVNLV--LKNTQAA----------EALVKL-Y 1231

Query: 122  NLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGA 181
              KL +E  +     ++   +  +   R + ++ +  F  L DE+Q     S+E+     
Sbjct: 1232 ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEM----- 1286

Query: 182  PVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKE 241
                            +  KER  D++        +H  KE+  +L++  +   V+    
Sbjct: 1287 ---------------FKTYKERDLDFD--------WH--KEKADQLVERWQNVHVQIDNR 1321

Query: 242  LGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQR------PHCSNVSAKNLQQ 295
            L D   +   L+  ++    +D          +  + + QR      P  S   A  L Q
Sbjct: 1322 LRDLEGIGKSLKYYRDTYHPLDDW--------IQQVETTQRKIQENQPENSKTLATQLNQ 1373

Query: 296  QLELLEEDSMKW------RAKAEEYGRTLS----RSVEYCAMRDEINE-------LKDSF 338
            Q  L+ E  MK       +  AE+Y  T+     +++ Y AM D   +       ++ S 
Sbjct: 1374 QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSA 1433

Query: 339  KDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFL 398
              I ++F +L+  YT           +    Q +    + ++ L+ + + +  +  +   
Sbjct: 1434 DLIIQEFMDLRTRYTA---------LVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH-- 1482

Query: 399  NYPSDKVNVLLEVMKDLQKHVDDFDKVVTD--------YKKNLDLTEHFQEVIEECHFWY 450
                      +E  K+LQK V +  K + D        + K    +E      E+     
Sbjct: 1483 ----------VEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1532

Query: 451  EDASATVVRVGKYSTECKTKEA---VKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYG 507
            +     + + G   T+ +  E    VK L + +N   + S+ Q +E  Q + D+      
Sbjct: 1533 QTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQES-QTSGDV------ 1585

Query: 508  LEEGQKYIEKIVT-KHKEVLESVTELCESLTELEEKL 543
                 K  EKIV  + +E  E +  +C+ LT+ E +L
Sbjct: 1586 -----KVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1617



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 91/514 (17%), Positives = 190/514 (36%), Gaps = 93/514 (18%)

Query: 154  DMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQ-QLKDLIHFHQKQKERIQDYEDILY 212
            +  P    +  +++ + K+  +L  R    +E+ +  +K L  F+ K KE    +  +L 
Sbjct: 3197 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE----FSILLQ 3252

Query: 213  KVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSL 272
            K  +  + +  +G      E E + Q   +      +  +   Q KQ  V+ L       
Sbjct: 3253 KAEEHEESQGPVGM-----ETETINQQLNMFKVFQKE-EIEPLQGKQQDVNWL------- 3299

Query: 273  GVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCA-MRDEI 331
            G  +I S  +    + S + L+  L+ +         K  +    L  ++ +C   +D +
Sbjct: 3300 GQGLIQSAAK----STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3355

Query: 332  NELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQ-------VDMYAEKMQALKR 384
              L     D ++   N K         S   K +K QIQ+       +D     ++ +KR
Sbjct: 3356 ESLLSWMVDTEELVANQK-------PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKR 3408

Query: 385  KMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLT---EHFQE 441
            + EK++          P+DKV +L ++     +     +K  T  ++   ++   + F E
Sbjct: 3409 EGEKIATTAE------PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHE 3462

Query: 442  VIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQF-------NKFIAPSVP----- 489
             +E  + W       +V      T+    E     H+         NK +  +V      
Sbjct: 3463 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3522

Query: 490  ------QQEERIQEATDLAQHLYGLEEGQK------YIEKIVTKHKEVLESVTELCESLT 537
                  + ++ +Q   D +Q  Y +E  +K       +++ +   K   E   EL   L 
Sbjct: 3523 KVLSSREDKDMVQSKLDFSQVWY-IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLN 3581

Query: 538  ELEEKLK----------------------QGDVLKMNPNLEDFHYDYIDLLKEPAKNKQT 575
            E+ +KL                       Q D+L    N++    + ++LLK+   ++  
Sbjct: 3582 EVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL 3641

Query: 576  IFNEERNKGQVQVADLLGINGTGEERLPQDLKVS 609
            I  ++    + +  D+  ++    + L Q L+++
Sbjct: 3642 IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3675



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 98/544 (18%), Positives = 213/544 (39%), Gaps = 87/544 (15%)

Query: 86   EELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFI 145
            +E+ L+    ++    SK   Q ++   E L K    L++LQE ++    L      Q +
Sbjct: 3572 DEVELMNWLNEVHDKLSKLSVQDYST--EGLWKQQSELRVLQEDIL----LRKQNVDQAL 3625

Query: 146  LDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQ 205
            L      N ++   Q   DEV  I  + E +  R   + + S  +   +           
Sbjct: 3626 L------NGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL----------- 3668

Query: 206  DYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDV-QIHLRCSQEKQARVDH 264
              E  L    + H   EEL   +   E+E +    ++    +  Q  +R    K+ + + 
Sbjct: 3669 --EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR---PKELKKEA 3723

Query: 265  LHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRA-------KAEEYGRT 317
             +  AL   +D ++ V       V  +  +   +++ ED+ ++R        K EE    
Sbjct: 3724 KNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA 3780

Query: 318  LSRSVEYCAMRD-EINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYA 376
            + RS ++    D E++ + ++    +KK  +L     ++++ S  L+  K    ++  + 
Sbjct: 3781 ILRSQQFDQAADAELSWITET----EKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHK 3836

Query: 377  EKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLD-- 434
            + +  L +   K+    S+        K++ +L       K+ D   ++ ++    L+  
Sbjct: 3837 DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVL-------KNYDTICQINSERYLQLERA 3889

Query: 435  --LTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQE 492
              L   F E  EE   W  +  + + ++   + E +T    +  H+Q  + IA   P  +
Sbjct: 3890 QSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3949

Query: 493  ER-----------------IQEATDLAQHLYG-LEEGQKY----IEKIVTKHKEVLESVT 530
            +                  IQE    A  LY  ++E  K     +++ +++  +  + + 
Sbjct: 3950 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4009

Query: 531  ELCESLTELEEKLKQ-----GDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQ 585
            ++ ESL  + E+L+Q      +V K+   + +     +D+ K      Q ++   + +G+
Sbjct: 4010 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEK-----LQPLYETLKQRGE 4064

Query: 586  VQVA 589
              +A
Sbjct: 4065 EMIA 4068



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 44/220 (20%), Positives = 99/220 (45%), Gaps = 30/220 (13%)

Query: 329  DEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEK 388
            +E NEL+   K +++ +N L     K+ ++S+    +K + + V   AE+ Q  K K++ 
Sbjct: 1549 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIV---AERQQEYKEKLQG 1605

Query: 389  VSN---KTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEE 445
            + +   +T +  + +   +  ++ +   +L+K+    +++  D + +    +   EV++ 
Sbjct: 1606 ICDLLTQTENRLIGH--QEAFMIGDGTVELKKYQSKQEELQKDMQGS---AQALAEVVKN 1660

Query: 446  CHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFN-----------KFIAPSVPQQEER 494
               + ++    + +  K   E K  EA KI  +Q N           K +  ++ ++ E+
Sbjct: 1661 TENFLKENGEKLSQEDKALIEQKLNEA-KIKCEQLNLKAEQSKKELDKVVTTAIKEETEK 1719

Query: 495  I-------QEATDLAQHLYGLEEGQKYIEKIVTKHKEVLE 527
            +       +  T +   L  L    K  E+  TKHK+V+E
Sbjct: 1720 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE 1759



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 44/253 (17%), Positives = 96/253 (37%), Gaps = 46/253 (18%)

Query: 291  KNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDI--------- 341
            + L+++LE L++D      K EE+    + S     +R E+N +  +   +         
Sbjct: 1150 EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1209

Query: 342  KKKFNNLKFNYTK----------------------KNEKSRNLKALKYQIQQVDMYAEKM 379
            K K  NL    T+                      KN     +  LK    +VD   +  
Sbjct: 1210 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1269

Query: 380  QALKRKMEKVSNKTSDSFLNYP---------SDKVNVLLEVMKDLQKHVDDFDKVVTDYK 430
             AL+ +++K    + + F  Y           +K + L+E  +++   +D+  + +    
Sbjct: 1270 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1329

Query: 431  KNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQ 490
            K+L   +++++       W +    T  ++ +   E  +K     L+QQ  K +   +  
Sbjct: 1330 KSL---KYYRDTYHPLDDWIQQVETTQRKIQENQPE-NSKTLATQLNQQ--KMLVSEIEM 1383

Query: 491  QEERIQEATDLAQ 503
            ++ ++ E    A+
Sbjct: 1384 KQSKMDECQKYAE 1396



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 16/54 (29%), Positives = 32/54 (59%), Gaps = 3/54 (5%)

Query: 111  AFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLND 164
            + K  +K+T+  + ++Q +     A DLG SL+    L++KW+   P+ Q++N+
Sbjct: 2337 SLKSWIKETTKKVPIVQPSF---GAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2387


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 122/583 (20%), Positives = 226/583 (38%), Gaps = 77/583 (13%)

Query: 86   EELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALD---LGGSL 142
            +EL+ L +  Q K  ES     Q+   + QLK+     +L+   L P+S +D   L    
Sbjct: 2699 QELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLS-IDPNMLNTQR 2757

Query: 143  QFILDLRQKWNDMKPQFQQLNDEVQYIM-KESEELTGRGAPVKEKSQQLKDLIHFHQKQK 201
            Q +  L Q++   KPQ++QL    Q I+ +  E+ + RG   ++ +   +       +  
Sbjct: 2758 QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2817

Query: 202  ERIQDYEDILYKVVQFHQVKEELGRLIK------SRELEFVEQPKELGDAHDVQIHLRCS 255
            +R    +  + K  Q+  +   L   +       S  L     P  +     ++   +  
Sbjct: 2818 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN--QQLETAQKMK 2875

Query: 256  QEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYG 315
            QE Q     + ++A +L  D+ + V+  +        L +QLE + +       KAE + 
Sbjct: 2876 QEIQQEKKQI-KVAQALCEDLSALVKEEYLK----AELSRQLEGILKSFKDVEQKAENHV 2930

Query: 316  RTLSRSVEYCAMRDEINELKDSFK---DIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQV 372
            + L  +   CA   +  ++   F+   D KK+  N      K +  S  L  L+  I+  
Sbjct: 2931 QHLQSA---CASSHQFQQMSRDFQAWLDTKKEEQN------KSHPISAKLDVLESLIKDH 2981

Query: 373  DMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTD---- 428
              +++ + A     EK   +  +  L     +   L   +  ++ + D F+K V +    
Sbjct: 2982 KDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENK 3041

Query: 429  YKKNLDLTEHFQEVIEECHFWYEDASATVVRV--------GKYSTECKTKEAVKILHQQF 480
             K++L+    ++E +E    W +     +  +        G+ S   K K   K + Q F
Sbjct: 3042 LKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI-AKLKSLQKEMDQHF 3100

Query: 481  ----------NKFIAPSVPQQEERIQEATDLAQHLYGLEE---GQKY-IEKIVTKHKEVL 526
                      N  ++     +E    E   L Q +  + E    +K+ +E +  K KE  
Sbjct: 3101 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 3160

Query: 527  ESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQV 586
            E   E    L   +E+L   D L      + +   Y+ +L+   K+ Q +      K QV
Sbjct: 3161 EVSKESKRQLQCAKEQLDIHDSL----GSQAYSNKYLTMLQTQQKSLQAL------KHQV 3210

Query: 587  QVADLLGINGTGEERLPQDLKVSTDKEGGVQDLLLPEDMLSGE 629
             +A          +RL QDL V      G  D+LL  + ++ E
Sbjct: 3211 DLA----------KRLAQDLVVEASDSKGTSDVLLQVETIAQE 3243



 Score = 37.0 bits (84), Expect = 0.080
 Identities = 102/517 (19%), Positives = 193/517 (37%), Gaps = 125/517 (24%)

Query: 62   NEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSH 121
            N +L   N+VY M +T        ++L  + L   LK T++           E L K  +
Sbjct: 1329 NVVLQNMNQVYSMSSTYI------DKLKTVNLV--LKNTQAA----------EALVKL-Y 1369

Query: 122  NLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGA 181
              KL +E  +     ++   +  +   R + ++ +  F  L DE+Q     S+E+     
Sbjct: 1370 ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEM----- 1424

Query: 182  PVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKE 241
                            +  KER  D++        +H  KE+  +L++  +   V+    
Sbjct: 1425 ---------------FKTYKERDLDFD--------WH--KEKADQLVERWQNVHVQIDNR 1459

Query: 242  LGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQR------PHCSNVSAKNLQQ 295
            L D   +   L+  ++    +D          +  + + QR      P  S   A  L Q
Sbjct: 1460 LRDLEGIGKSLKYYRDTYHPLDDW--------IQQVETTQRKIQENQPENSKTLATQLNQ 1511

Query: 296  QLELLEEDSMKW------RAKAEEYGRTLS----RSVEYCAMRDEINE-------LKDSF 338
            Q  L+ E  MK       +  AE+Y  T+     +++ Y AM D   +       ++ S 
Sbjct: 1512 QKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSA 1571

Query: 339  KDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFL 398
              I ++F +L+  YT           +    Q +    + ++ L+ + + +  +  +   
Sbjct: 1572 DLIIQEFMDLRTRYTA---------LVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEH-- 1620

Query: 399  NYPSDKVNVLLEVMKDLQKHVDDFDKVVTD--------YKKNLDLTEHFQEVIEECHFWY 450
                      +E  K+LQK V +  K + D        + K    +E      E+     
Sbjct: 1621 ----------VEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1670

Query: 451  EDASATVVRVGKYSTECKTKEA---VKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYG 507
            +     + + G   T+ +  E    VK L + +N   + S+ Q +E  Q + D+      
Sbjct: 1671 QTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQES-QTSGDV------ 1723

Query: 508  LEEGQKYIEKIVT-KHKEVLESVTELCESLTELEEKL 543
                 K  EKIV  + +E  E +  +C+ LT+ E +L
Sbjct: 1724 -----KVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1755



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 91/514 (17%), Positives = 190/514 (36%), Gaps = 93/514 (18%)

Query: 154  DMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQ-QLKDLIHFHQKQKERIQDYEDILY 212
            +  P    +  +++ + K+  +L  R    +E+ +  +K L  F+ K KE    +  +L 
Sbjct: 3335 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE----FSILLQ 3390

Query: 213  KVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSL 272
            K  +  + +  +G      E E + Q   +      +  +   Q KQ  V+ L       
Sbjct: 3391 KAEEHEESQGPVGM-----ETETINQQLNMFKVFQKE-EIEPLQGKQQDVNWL------- 3437

Query: 273  GVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCA-MRDEI 331
            G  +I S  +    + S + L+  L+ +         K  +    L  ++ +C   +D +
Sbjct: 3438 GQGLIQSAAK----STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3493

Query: 332  NELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQ-------VDMYAEKMQALKR 384
              L     D ++   N K         S   K +K QIQ+       +D     ++ +KR
Sbjct: 3494 ESLLSWMVDTEELVANQK-------PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKR 3546

Query: 385  KMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLT---EHFQE 441
            + EK++          P+DKV +L ++     +     +K  T  ++   ++   + F E
Sbjct: 3547 EGEKIATTAE------PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHE 3600

Query: 442  VIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQF-------NKFIAPSVP----- 489
             +E  + W       +V      T+    E     H+         NK +  +V      
Sbjct: 3601 TLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL 3660

Query: 490  ------QQEERIQEATDLAQHLYGLEEGQK------YIEKIVTKHKEVLESVTELCESLT 537
                  + ++ +Q   D +Q  Y +E  +K       +++ +   K   E   EL   L 
Sbjct: 3661 KVLSSREDKDMVQSKLDFSQVWY-IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLN 3719

Query: 538  ELEEKLK----------------------QGDVLKMNPNLEDFHYDYIDLLKEPAKNKQT 575
            E+ +KL                       Q D+L    N++    + ++LLK+   ++  
Sbjct: 3720 EVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL 3779

Query: 576  IFNEERNKGQVQVADLLGINGTGEERLPQDLKVS 609
            I  ++    + +  D+  ++    + L Q L+++
Sbjct: 3780 IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA 3813



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 98/544 (18%), Positives = 213/544 (39%), Gaps = 87/544 (15%)

Query: 86   EELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFI 145
            +E+ L+    ++    SK   Q ++   E L K    L++LQE ++    L      Q +
Sbjct: 3710 DEVELMNWLNEVHDKLSKLSVQDYST--EGLWKQQSELRVLQEDIL----LRKQNVDQAL 3763

Query: 146  LDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQ 205
            L      N ++   Q   DEV  I  + E +  R   + + S  +   +           
Sbjct: 3764 L------NGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL----------- 3806

Query: 206  DYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDV-QIHLRCSQEKQARVDH 264
              E  L    + H   EEL   +   E+E +    ++    +  Q  +R    K+ + + 
Sbjct: 3807 --EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR---PKELKKEA 3861

Query: 265  LHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRA-------KAEEYGRT 317
             +  AL   +D ++ V       V  +  +   +++ ED+ ++R        K EE    
Sbjct: 3862 KNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA 3918

Query: 318  LSRSVEYCAMRD-EINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYA 376
            + RS ++    D E++ + ++    +KK  +L     ++++ S  L+  K    ++  + 
Sbjct: 3919 ILRSQQFDQAADAELSWITET----EKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHK 3974

Query: 377  EKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLD-- 434
            + +  L +   K+    S+        K++ +L       K+ D   ++ ++    L+  
Sbjct: 3975 DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVL-------KNYDTICQINSERYLQLERA 4027

Query: 435  --LTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQE 492
              L   F E  EE   W  +  + + ++   + E +T    +  H+Q  + IA   P  +
Sbjct: 4028 QSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 4087

Query: 493  ER-----------------IQEATDLAQHLYG-LEEGQKY----IEKIVTKHKEVLESVT 530
            +                  IQE    A  LY  ++E  K     +++ +++  +  + + 
Sbjct: 4088 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4147

Query: 531  ELCESLTELEEKLKQ-----GDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQ 585
            ++ ESL  + E+L+Q      +V K+   + +     +D+ K      Q ++   + +G+
Sbjct: 4148 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEK-----LQPLYETLKQRGE 4202

Query: 586  VQVA 589
              +A
Sbjct: 4203 EMIA 4206



 Score = 34.7 bits (78), Expect = 0.40
 Identities = 44/220 (20%), Positives = 99/220 (45%), Gaps = 30/220 (13%)

Query: 329  DEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEK 388
            +E NEL+   K +++ +N L     K+ ++S+    +K + + V   AE+ Q  K K++ 
Sbjct: 1687 EERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIV---AERQQEYKEKLQG 1743

Query: 389  VSN---KTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEE 445
            + +   +T +  + +   +  ++ +   +L+K+    +++  D + +    +   EV++ 
Sbjct: 1744 ICDLLTQTENRLIGH--QEAFMIGDGTVELKKYQSKQEELQKDMQGS---AQALAEVVKN 1798

Query: 446  CHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFN-----------KFIAPSVPQQEER 494
               + ++    + +  K   E K  EA KI  +Q N           K +  ++ ++ E+
Sbjct: 1799 TENFLKENGEKLSQEDKALIEQKLNEA-KIKCEQLNLKAEQSKKELDKVVTTAIKEETEK 1857

Query: 495  I-------QEATDLAQHLYGLEEGQKYIEKIVTKHKEVLE 527
            +       +  T +   L  L    K  E+  TKHK+V+E
Sbjct: 1858 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE 1897



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 44/253 (17%), Positives = 96/253 (37%), Gaps = 46/253 (18%)

Query: 291  KNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDI--------- 341
            + L+++LE L++D      K EE+    + S     +R E+N +  +   +         
Sbjct: 1288 EKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1347

Query: 342  KKKFNNLKFNYTK----------------------KNEKSRNLKALKYQIQQVDMYAEKM 379
            K K  NL    T+                      KN     +  LK    +VD   +  
Sbjct: 1348 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1407

Query: 380  QALKRKMEKVSNKTSDSFLNYP---------SDKVNVLLEVMKDLQKHVDDFDKVVTDYK 430
             AL+ +++K    + + F  Y           +K + L+E  +++   +D+  + +    
Sbjct: 1408 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1467

Query: 431  KNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQ 490
            K+L   +++++       W +    T  ++ +   E  +K     L+QQ  K +   +  
Sbjct: 1468 KSL---KYYRDTYHPLDDWIQQVETTQRKIQENQPE-NSKTLATQLNQQ--KMLVSEIEM 1521

Query: 491  QEERIQEATDLAQ 503
            ++ ++ E    A+
Sbjct: 1522 KQSKMDECQKYAE 1534



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 16/54 (29%), Positives = 32/54 (59%), Gaps = 3/54 (5%)

Query: 111  AFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLND 164
            + K  +K+T+  + ++Q +     A DLG SL+    L++KW+   P+ Q++N+
Sbjct: 2475 SLKSWIKETTKKVPIVQPSF---GAEDLGKSLEDTKKLQEKWSLKTPEIQKVNN 2525


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,201,141
Number of Sequences: 37866
Number of extensions: 1588042
Number of successful extensions: 8578
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 112
Number of HSP's successfully gapped in prelim test: 521
Number of HSP's that attempted gapping in prelim test: 6340
Number of HSP's gapped (non-prelim): 2272
length of query: 875
length of database: 18,247,518
effective HSP length: 111
effective length of query: 764
effective length of database: 14,044,392
effective search space: 10729915488
effective search space used: 10729915488
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.