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Search of human proteins with 38788333
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
(1441 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38788333 remodeling and spacing factor 1 [Homo sapiens] 2864 0.0
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 127 6e-29
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 127 6e-29
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 118 4e-26
gi|221219020 NYD-SP11 protein [Homo sapiens] 103 1e-21
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 102 3e-21
gi|148746195 trichohyalin [Homo sapiens] 99 4e-20
gi|87299628 biorientation of chromosomes in cell division 1-like... 92 3e-18
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 87 9e-17
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 82 3e-15
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 82 3e-15
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 82 3e-15
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 82 4e-15
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 82 4e-15
gi|71061468 centromere protein E [Homo sapiens] 82 5e-15
gi|150170670 piccolo isoform 2 [Homo sapiens] 82 5e-15
gi|150378539 piccolo isoform 1 [Homo sapiens] 82 5e-15
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 77 9e-14
gi|118498362 kinectin 1 isoform b [Homo sapiens] 77 1e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 76 3e-13
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 75 6e-13
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 75 6e-13
gi|104526627 triadin [Homo sapiens] 75 6e-13
gi|118498356 kinectin 1 isoform a [Homo sapiens] 74 1e-12
gi|33620775 kinectin 1 isoform a [Homo sapiens] 74 1e-12
gi|55770834 centromere protein F [Homo sapiens] 74 1e-12
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)... 73 2e-12
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)... 73 2e-12
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)... 73 2e-12
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 72 4e-12
>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
Length = 1441
Score = 2864 bits (7424), Expect = 0.0
Identities = 1441/1441 (100%), Positives = 1441/1441 (100%)
Query: 1 MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGN 60
MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGN
Sbjct: 1 MATAAAAAAVMAPPGCPGSCPNFAVVCSFLERYGPLLDLPELPFPELERVLQAPPPDVGN 60
Query: 61 GEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKL 120
GEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKL
Sbjct: 61 GEVPKELVELHLKLMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVECKL 120
Query: 121 ALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQ 180
ALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQ
Sbjct: 121 ALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQ 180
Query: 181 DDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEE 240
DDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEE
Sbjct: 181 DDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEE 240
Query: 241 TPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLP 300
TPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLP
Sbjct: 241 TPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLP 300
Query: 301 ENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSS 360
ENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSS
Sbjct: 301 ENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSS 360
Query: 361 HEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQ 420
HEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQ
Sbjct: 361 HEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQ 420
Query: 421 EEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNI 480
EEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNI
Sbjct: 421 EEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNI 480
Query: 481 ITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETS 540
ITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETS
Sbjct: 481 ITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETS 540
Query: 541 LDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDA 600
LDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDA
Sbjct: 541 LDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDA 600
Query: 601 QRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQS 660
QRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQS
Sbjct: 601 QRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQS 660
Query: 661 VKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASE 720
VKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASE
Sbjct: 661 VKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASE 720
Query: 721 NTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPR 780
NTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPR
Sbjct: 721 NTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPR 780
Query: 781 ISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPK 840
ISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPK
Sbjct: 781 ISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPK 840
Query: 841 GKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLP 900
GKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLP
Sbjct: 841 GKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLP 900
Query: 901 NHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKK 960
NHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKK
Sbjct: 901 NHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKK 960
Query: 961 KERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCIS 1020
KERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCIS
Sbjct: 961 KERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCIS 1020
Query: 1021 YRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRA 1080
YRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRA
Sbjct: 1021 YRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRA 1080
Query: 1081 AAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSD 1140
AAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSD
Sbjct: 1081 AAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSD 1140
Query: 1141 TDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFV 1200
TDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFV
Sbjct: 1141 TDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFV 1200
Query: 1201 ETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSED 1260
ETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSED
Sbjct: 1201 ETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSED 1260
Query: 1261 DELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQ 1320
DELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQ
Sbjct: 1261 DELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQ 1320
Query: 1321 PARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAI 1380
PARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAI
Sbjct: 1321 PARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAI 1380
Query: 1381 ENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQ 1440
ENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQ
Sbjct: 1381 ENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQ 1440
Query: 1441 L 1441
L
Sbjct: 1441 L 1441
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 127 bits (320), Expect = 6e-29
Identities = 248/1234 (20%), Positives = 474/1234 (38%), Gaps = 188/1234 (15%)
Query: 202 LALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMD 261
L K+ + + + + +++ + E +++ +K + K + K K + E+P
Sbjct: 354 LKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCA 413
Query: 262 LENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFK--ENV 319
LE + + E +K+ + E +P + E KK ++E ++
Sbjct: 414 LEKKDISKS-EAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTS 472
Query: 320 KPIKVEVKECRAD-PKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQ 378
+ + +++ + P+D ++E + + G + + E S+ + D
Sbjct: 473 EDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDN 532
Query: 379 QAKIPLKKREIKLSDDF----------DSPVKGPLCKSVTPTKEFLKD-EIKQEEETCKR 427
+ I K K++ + +SP+KG C+ V K+ K + + E C
Sbjct: 533 RGGIK-SKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKC-- 589
Query: 428 ISTITALGHEG---KQLVNGEVS------DERVAPNFKTEPIETKFYETKEESYSPSKDR 478
LG E + LV EVS D R +P KT P+ S S +
Sbjct: 590 -----GLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECN 644
Query: 479 NIITEG----------NGTESLNSVITSMKTGELEK----ETAPLRKDADSSISVLEIHS 524
+ E + S +S I + K +L K ET D+D +++L+ S
Sbjct: 645 ETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVS 704
Query: 525 QKAQIEEPDPP------------EMETSLDSSEMAKDLSSKTALSSTESCTMKGEE-KSP 571
+ + D +++T + K K++ S ++ T KG+ KS
Sbjct: 705 RMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKR-KRKSSTSGSDFDTKKGKSAKSS 763
Query: 572 KTKKDKRPPILECLE---KLEKSKKTFLDKDAQRLSP--IPEEVPKSTLESEKPGSPEAA 626
K KR E +LEK K+ A R + IP + E EK S +
Sbjct: 764 IISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKH-SKKGM 822
Query: 627 ETSPPSNIIDHCEKLASEKEVVECQST-STVGGQSVKKVDLETLKEDSEFTKVEMDNLDN 685
+ N+ E + + E + + T S+ G K + L++ ++ +
Sbjct: 823 DNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRD-----RLPKKQQAS 877
Query: 686 AQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKK 745
A T G+++ S + S + + + V E + + T ++ ++G+ I+ + K
Sbjct: 878 ASTDGVDKLSGKEQSF--TSLEVRKVAETKEKSKHLKTKTCKKVQDGLS---DIAEKFLK 932
Query: 746 PDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGED 805
D + E + KQ K EE+K + S KV ++ Q G +
Sbjct: 933 KDQSDETSEDDKKQSKKGTEEKK-----------KPSDFKKKVIKMEQQYESSSDGTEKL 981
Query: 806 EVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGS 865
EE K K+ +K D K K++ K T + Y+ +G
Sbjct: 982 PEREEICHFPKGIKQ--IKNGTTDGEKKSKKIRDK-----TSKKKDELSDYAEKSTGKGD 1034
Query: 866 GSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPL 925
+ S E+K+S+ + + CK G + C S D+ ++
Sbjct: 1035 SCDSS-------EDKKSKNGAYGREKKRCKLLGKSSRKRQD--CSSSDTEKYS------- 1078
Query: 926 MIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQ 985
+ DG C +++L+ +++ +++ + +R + + G S +
Sbjct: 1079 -MKEDG------------CNSSDKRLKRIELR-ERRNLSSKRNTKEIQSGSSSSDA---- 1120
Query: 986 EPDFSEDQEEKKK--DSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADG 1043
+ SED ++KK+ SKK + E++ R + + + IEDD + + G
Sbjct: 1121 -EESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIG 1179
Query: 1044 GGVGRGKDISTIT------GHRG-----------KDISTILDEERKENKRPQRAAAARRK 1086
G + I +T H G K + +D++ +N R A
Sbjct: 1180 EGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL 1239
Query: 1087 KRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSR 1146
+ + N L SD + ++ +E K G Q+E ENP + E N +SD+D
Sbjct: 1240 EEIKAN-LSSDEDGSSDDEPEEGKKRTGKQNE-----ENPGDEEAKNQVNSESDSDSEES 1293
Query: 1147 RLRRHPSRPMRQSRRL-------RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDF 1199
+ R+ R +R + +KT K++ + + +S DSE DF +
Sbjct: 1294 KKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSED---SDFQESG 1350
Query: 1200 VETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSE 1259
V S Q+ + + +E + +Q+S ++ K+ RR+ + SSSE++ NSE
Sbjct: 1351 VSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENK-----SNSE 1405
Query: 1260 DDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPS------RKRLHRIETDEEESCDN 1313
++E KE + +E E +EEEEE+E S RK++ +I D++ +
Sbjct: 1406 EEEEEKEEE----------EEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTET 1455
Query: 1314 AHGDANQPARDSQPRVLPSEQESTKKPYRIESDE 1347
+A + + + R+ E+E K IE ++
Sbjct: 1456 Q--NALKEEEERRKRIAEREREREKLREVIEIED 1487
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/117 (26%), Positives = 60/117 (51%), Gaps = 18/117 (15%)
Query: 219 QQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENR------------- 265
Q+D+SS + E+EE +KEEE ++EE++E E+ ++++ + R
Sbjct: 1393 QEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLR 1452
Query: 266 -STANVLEETTVKKEK--EDEKELVKLPVIVKLEKPLPEN--EEKKIIKEESDSFKE 317
T N L+E ++++ E E+E KL ++++E P K++ +E + KE
Sbjct: 1453 TETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKE 1509
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 127 bits (320), Expect = 6e-29
Identities = 248/1234 (20%), Positives = 474/1234 (38%), Gaps = 188/1234 (15%)
Query: 202 LALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMD 261
L K+ + + + + +++ + E +++ +K + K + K K + E+P
Sbjct: 392 LKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKEHKVIDAKFETKARKGEKPCA 451
Query: 262 LENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFK--ENV 319
LE + + E +K+ + E +P + E KK ++E ++
Sbjct: 452 LEKKDISKS-EAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTS 510
Query: 320 KPIKVEVKECRAD-PKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQ 378
+ + +++ + P+D ++E + + G + + E S+ + D
Sbjct: 511 EDLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDN 570
Query: 379 QAKIPLKKREIKLSDDF----------DSPVKGPLCKSVTPTKEFLKD-EIKQEEETCKR 427
+ I K K++ + +SP+KG C+ V K+ K + + E C
Sbjct: 571 RGGIK-SKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKC-- 627
Query: 428 ISTITALGHEG---KQLVNGEVS------DERVAPNFKTEPIETKFYETKEESYSPSKDR 478
LG E + LV EVS D R +P KT P+ S S +
Sbjct: 628 -----GLGQENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECN 682
Query: 479 NIITEG----------NGTESLNSVITSMKTGELEK----ETAPLRKDADSSISVLEIHS 524
+ E + S +S I + K +L K ET D+D +++L+ S
Sbjct: 683 ETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVS 742
Query: 525 QKAQIEEPDPP------------EMETSLDSSEMAKDLSSKTALSSTESCTMKGEE-KSP 571
+ + D +++T + K K++ S ++ T KG+ KS
Sbjct: 743 RMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKR-KRKSSTSGSDFDTKKGKSAKSS 801
Query: 572 KTKKDKRPPILECLE---KLEKSKKTFLDKDAQRLSP--IPEEVPKSTLESEKPGSPEAA 626
K KR E +LEK K+ A R + IP + E EK S +
Sbjct: 802 IISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKH-SKKGM 860
Query: 627 ETSPPSNIIDHCEKLASEKEVVECQST-STVGGQSVKKVDLETLKEDSEFTKVEMDNLDN 685
+ N+ E + + E + + T S+ G K + L++ ++ +
Sbjct: 861 DNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIMELRD-----RLPKKQQAS 915
Query: 686 AQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKK 745
A T G+++ S + S + + + V E + + T ++ ++G+ I+ + K
Sbjct: 916 ASTDGVDKLSGKEQSF--TSLEVRKVAETKEKSKHLKTKTCKKVQDGLS---DIAEKFLK 970
Query: 746 PDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGED 805
D + E + KQ K EE+K + S KV ++ Q G +
Sbjct: 971 KDQSDETSEDDKKQSKKGTEEKK-----------KPSDFKKKVIKMEQQYESSSDGTEKL 1019
Query: 806 EVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGS 865
EE K K+ +K D K K++ K T + Y+ +G
Sbjct: 1020 PEREEICHFPKGIKQ--IKNGTTDGEKKSKKIRDK-----TSKKKDELSDYAEKSTGKGD 1072
Query: 866 GSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPL 925
+ S E+K+S+ + + CK G + C S D+ ++
Sbjct: 1073 SCDSS-------EDKKSKNGAYGREKKRCKLLGKSSRKRQD--CSSSDTEKYS------- 1116
Query: 926 MIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQ 985
+ DG C +++L+ +++ +++ + +R + + G S +
Sbjct: 1117 -MKEDG------------CNSSDKRLKRIELR-ERRNLSSKRNTKEIQSGSSSSDA---- 1158
Query: 986 EPDFSEDQEEKKK--DSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADG 1043
+ SED ++KK+ SKK + E++ R + + + IEDD + + G
Sbjct: 1159 -EESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIG 1217
Query: 1044 GGVGRGKDISTIT------GHRG-----------KDISTILDEERKENKRPQRAAAARRK 1086
G + I +T H G K + +D++ +N R A
Sbjct: 1218 EGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLL 1277
Query: 1087 KRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSR 1146
+ + N L SD + ++ +E K G Q+E ENP + E N +SD+D
Sbjct: 1278 EEIKAN-LSSDEDGSSDDEPEEGKKRTGKQNE-----ENPGDEEAKNQVNSESDSDSEES 1331
Query: 1147 RLRRHPSRPMRQSRRL-------RRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDF 1199
+ R+ R +R + +KT K++ + + +S DSE DF +
Sbjct: 1332 KKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSED---SDFQESG 1388
Query: 1200 VETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSE 1259
V S Q+ + + +E + +Q+S ++ K+ RR+ + SSSE++ NSE
Sbjct: 1389 VSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENK-----SNSE 1443
Query: 1260 DDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPS------RKRLHRIETDEEESCDN 1313
++E KE + +E E +EEEEE+E S RK++ +I D++ +
Sbjct: 1444 EEEEEKEEE----------EEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTET 1493
Query: 1314 AHGDANQPARDSQPRVLPSEQESTKKPYRIESDE 1347
+A + + + R+ E+E K IE ++
Sbjct: 1494 Q--NALKEEEERRKRIAEREREREKLREVIEIED 1525
Score = 46.2 bits (108), Expect = 2e-04
Identities = 31/117 (26%), Positives = 60/117 (51%), Gaps = 18/117 (15%)
Query: 219 QQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENR------------- 265
Q+D+SS + E+EE +KEEE ++EE++E E+ ++++ + R
Sbjct: 1431 QEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLR 1490
Query: 266 -STANVLEETTVKKEK--EDEKELVKLPVIVKLEKPLPEN--EEKKIIKEESDSFKE 317
T N L+E ++++ E E+E KL ++++E P K++ +E + KE
Sbjct: 1491 TETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKE 1547
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 118 bits (296), Expect = 4e-26
Identities = 161/621 (25%), Positives = 254/621 (40%), Gaps = 70/621 (11%)
Query: 226 ESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKE-KEDEK 284
E + +E T++EE+ K+EE KE E + EE E + E + +KE K K
Sbjct: 462 EETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVK 521
Query: 285 ELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPV 344
E K P E PE EE K E K P K E K P + KS EK
Sbjct: 522 EEAKSPA----EAKSPEKEEAKSPAEVKSPEKAK-SPAKEEAK----SPPEAKSP-EKEE 571
Query: 345 AQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLC 404
A+ P ++ KS + KS E K+ ++AK P+K+ E K + SPVK
Sbjct: 572 AKSPAEVKSPEKAKSPAKEEAKSPAEA---KSPEKAKSPVKE-EAKSPAEAKSPVKEE-A 626
Query: 405 KSVTPTK--EFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIET 462
KS K E K K+E ++ ++ + + + V E +P P+
Sbjct: 627 KSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV-- 684
Query: 463 KFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEI 522
K E+ SP K ++ + E + + EK +P++++A +
Sbjct: 685 -----KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKT------- 732
Query: 523 HSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTK--KDKRPP 580
+KA+ + + S E AK L K+ + T + K E +SP K + + P
Sbjct: 733 -PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA---KEEARSPADKFPEKAKSP 788
Query: 581 ILECLEKLEKSKKTFLD--KDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHC 638
+ E ++ EK+K + K ++ P EEV E EKP + E PP
Sbjct: 789 VKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE--PP------- 839
Query: 639 EKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETK 698
K A E++ T KK ++ KE++ + ++ + +E+P E+K
Sbjct: 840 -KKAEEEKAPATPKTEE------KK---DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889
Query: 699 GSMQKSKFK-YKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPEN 757
+K + + K VP E A E+ KE K + KK+PD K EP
Sbjct: 890 VEAKKEEAEDKKKVPTPEKEAPAKVEV-----KEDAKPKEKTEVAKKEPDD-AKAKEPSK 943
Query: 758 KQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKT 817
EK E EK + + P T A+ D+ K+ + + E E+S++ T
Sbjct: 944 PAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS---T 1000
Query: 818 DKKEILKKSEKDTNSKVSKVK 838
D+K+ K EK T K +K K
Sbjct: 1001 DQKD-SKPPEKATEDKAAKGK 1020
Score = 77.0 bits (188), Expect = 1e-13
Identities = 135/617 (21%), Positives = 226/617 (36%), Gaps = 72/617 (11%)
Query: 428 ISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGT 487
+ST + E K V + E V +TE + T+EE ++ EG
Sbjct: 432 VSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEE 491
Query: 488 ESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMA 547
E K+ E+ +P K+A S + +A+ E + + + S E A
Sbjct: 492 EEAEGGEEETKSPPAEEAASP-EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKA 550
Query: 548 KDLSSKTALSSTESCTMKGEE-------------KSPKTKKDKRPPILECLEKLEKSKKT 594
K + + A S E+ + + EE KSP ++ K P + EK + K
Sbjct: 551 KSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE 610
Query: 595 FLDKDAQRLSPIPEEV--PKSTLESEKPGSPEAAETSPPSNIIDHCEKLAS-EKEVVECQ 651
A+ SP+ EE P EK SP E P EK S EKE +
Sbjct: 611 EAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSP-------EKAKSPEKE----E 659
Query: 652 STSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLV 711
+ S +S K + ++ ++ K E + + A++ EE + + K + K
Sbjct: 660 AKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS- 718
Query: 712 PEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNV 771
PE+ + + T E+ K +K ++ SP K PE + K E
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVK---------EEAKSPEKAKSPEKAKTLDVKSPEAKTP 769
Query: 772 GRTLRRSPRISRPTAKVAEIRDQKADKKRGEG---EDEVEEESTALQKTDKKEILKKSEK 828
+ RSP P + ++++ ++ + ED E +K + K +K+ EK
Sbjct: 770 AKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829
Query: 829 DTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEE------KES 882
KV + K + + + K S E E E EE++E KES
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKE-EAPKKEAPKPKVEEKKEPAVEKPKES 888
Query: 883 EEAILADDDEPCKKCGLPNH--PELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQH 940
+ ++ E KK P P + + + T + PD P +
Sbjct: 889 KVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKE----PDDAKAKEPSKP 944
Query: 941 KLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDS 1000
EK E + D K+E+A++ +E+ P E ED + K+
Sbjct: 945 ---AEKKEAAPEKKDT---KEEKAKKPEEK------------PKTEAKAKEDDKTLSKEP 986
Query: 1001 KKSKANLLERRSTRTRK 1017
K KA E+ S+ +K
Sbjct: 987 SKPKAEKAEKSSSTDQK 1003
Score = 74.3 bits (181), Expect = 8e-13
Identities = 110/442 (24%), Positives = 183/442 (41%), Gaps = 49/442 (11%)
Query: 197 ELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSE 256
E A++ A K+ + + + +SP+ E+ ++ ++ ++P++EE K EK KS
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS- 668
Query: 257 EQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFK 316
P+ E +S ++ VK E + E K P VK E PE + K +KEE+ S +
Sbjct: 669 --PVKAEAKSPEKA--KSPVKAEAK-SPEKAKSP--VKEEAKSPE-KAKSPVKEEAKSPE 720
Query: 317 ENVKPIKVEVK---ECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEK 373
+ P+K E K + ++ K+ S EK A+ PE+ + ++KS T E
Sbjct: 721 KAKSPVKEEAKTPEKAKSPVKEEAKSPEK--AKSPEKAK-TLDVKSPEAKTPAKEEARSP 777
Query: 374 L-KNDQQAKIPLKKREIKLSDDFDSPVK--GPLCKSVTPTKEFLKDEIKQEEETCK-RIS 429
K ++AK P+K+ E+K + SP+K + P KE +K +K+EE+ + ++
Sbjct: 778 ADKFPEKAKSPVKE-EVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVK 836
Query: 430 TITALGHEGKQLV---NGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNG 486
E K E D + K E + K E KE + K+ + +
Sbjct: 837 EPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEE 896
Query: 487 TESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEM 546
E V T EKE AP K +++E P+ +T + E
Sbjct: 897 AEDKKKVPTP------EKE-AP----------------AKVEVKEDAKPKEKTEVAKKE- 932
Query: 547 AKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPI 606
D +K E E+K K +K K+P E K L K+ + P
Sbjct: 933 PDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSK--PK 990
Query: 607 PEEVPKSTLESEKPGSPEAAET 628
E+ KS+ +K P T
Sbjct: 991 AEKAEKSSSTDQKDSKPPEKAT 1012
Score = 55.8 bits (133), Expect = 3e-07
Identities = 102/625 (16%), Positives = 244/625 (39%), Gaps = 55/625 (8%)
Query: 746 PDSPPKV--------LEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKAD 797
P+ PK+ ++ E K + EK E++T + + ++ T +V E +++A
Sbjct: 423 PEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVI---VEEQTEETQVTEEVTEEEEKEAK 479
Query: 798 KKRG-EGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKY 856
++ G E E EEE+ ++ K +++ S VK + K + + + K
Sbjct: 480 EEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAK---SPAEAKSPEKE 536
Query: 857 SSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGY 916
+ +E EK+ + ++EE + E + + E K PE ++
Sbjct: 537 EAKSPAEVKSPEKAKSPAKEEAKSPPEAK--SPEKEEAKSPAEVKSPEKAKSPAKEEAKS 594
Query: 917 HTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGI 976
P P E P + K + EE +V +K ++ ++E
Sbjct: 595 PAEAKSPEKAKSPVKEEAKSPAEAKSPVK--EEAKSPAEVKSPEKAKSPTKEEAK----- 647
Query: 977 SIENIIPPQEPDFSEDQEEKK------KDSKKSKANL-LERRSTRTRKCISYRFDEFDEA 1029
S E P++ + ++ K K +K+K+ + E +S K + E
Sbjct: 648 SPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEK 707
Query: 1030 IDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRR 1089
++++ K + + K ++E K P++A + + K
Sbjct: 708 AKSPVKEEAKSPEKA--------KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL 759
Query: 1090 RLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDS---DTDFCSR 1146
+ ++ + EE K + ++ ++P++++ P +D+ + + +
Sbjct: 760 DVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKS--PLKEDAKAPEKEIPKK 817
Query: 1147 RLRRHPSRPMRQSRRLRRKTPKKKYSDDDE----EEESEENSRDSESDFSDDFSDDFVET 1202
+ P + + + ++ K P KK ++ + E +++S+ E+ + E
Sbjct: 818 EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK 877
Query: 1203 RRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDE 1262
+ + ++ ++ K++ E++ +K KE + + + E++ ++K DD
Sbjct: 878 KEPAVEKPKESKVEAKKE-EAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDA 936
Query: 1263 LAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPA 1322
AKE + K+ + ++ +E+ ++ E KP + E +E + ++P
Sbjct: 937 KAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKP------KTEAKAKEDDKTLSKEPSKPK 990
Query: 1323 RDSQPRVLPSEQESTKKPYRIESDE 1347
+ + ++Q+ +K P + D+
Sbjct: 991 AEKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 47.0 bits (110), Expect = 1e-04
Identities = 70/381 (18%), Positives = 145/381 (38%), Gaps = 27/381 (7%)
Query: 1073 ENKRPQRAAAARRKKRR---RLNDLDSDSNLDEEESEDEFKISDGSQDEF---VVSDENP 1126
E K P++A + +++ + + + + E+++ K S ++ V ++
Sbjct: 631 EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKS 690
Query: 1127 DESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRR--KTPKKKYSDDDEEEESEENS 1184
E + P + + ++ P + ++ KTP+K S EE +S E +
Sbjct: 691 PEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKA 750
Query: 1185 RDSESDFSDDFSDDFVETRRRRSRRNQ------------KRQINYKEDSESDGSQKSLRR 1232
+ E + D +T + R+ K ++ E ++S + +
Sbjct: 751 KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAP 810
Query: 1233 GKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEE 1292
KEI + + + E E+ K E + A+E K + T+E ++ +EE ++
Sbjct: 811 EKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPK---TEEKKDSKKEEAPKK 867
Query: 1293 GKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEEDFE 1352
P K + E E+ ++ + A D + P ++ K + ++ +E E
Sbjct: 868 EAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTE 927
Query: 1353 NVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGG 1412
K P D + PS + A E K EK++ P++ A + +
Sbjct: 928 VAKK--EPDDAKAKE-PSKPAEKKEAAPEKKDTK-EEKAKKPEEKPKTEAKAKEDDKTLS 983
Query: 1413 QEAGAPEEEEDELLRVTDLVD 1433
+E P+ E+ E TD D
Sbjct: 984 KEPSKPKAEKAEKSSSTDQKD 1004
Score = 46.2 bits (108), Expect = 2e-04
Identities = 83/453 (18%), Positives = 174/453 (38%), Gaps = 17/453 (3%)
Query: 982 IPPQEPDFSEDQEEKKKDSKKSKAN--LLERRSTRTRKCISYRFDEFDEAIDEAIEDDI- 1038
IP EEK K +KS+ ++E ++ T+ +E EA +E +++
Sbjct: 429 IPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEG 488
Query: 1039 ---KEADGGGVGRGKDISTITGHRGKDISTILDEERK---ENKRPQRAAAARRKKRRRLN 1092
+EA+GG + K+ + + EE K E K P++ A + +
Sbjct: 489 GEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPE 548
Query: 1093 DLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHP 1152
S + +E +S E K + + + ++P++++ S + S + P
Sbjct: 549 KAKSPAK-EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSP 607
Query: 1153 SRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQK 1212
+ +S K+P K+ + E +S E ++ + + + + ++ +K
Sbjct: 608 VKEEAKSPA-EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS-PEKAKSPEKEEAKSPEK 665
Query: 1213 RQINYKEDSESDGSQKS--LRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRS 1270
+ K +++S KS K + ++S E S E+ + +++K
Sbjct: 666 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSP 725
Query: 1271 VRKRGRSTDEY-SEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRV 1329
V++ ++ ++ S EE + E S ++ ++ E+ A +A PA +
Sbjct: 726 VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785
Query: 1330 LPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTE 1389
+E K P + +S +ED + K + V P + P + K E
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE--VKSPVKEEEKPQEVKVKEPPKKAE 843
Query: 1390 KSQTPKDNSTASASLASNGTSGGQEAGAPEEEE 1422
+ + P T + + +EA P+ EE
Sbjct: 844 EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE 876
Score = 43.1 bits (100), Expect = 0.002
Identities = 63/347 (18%), Positives = 137/347 (39%), Gaps = 28/347 (8%)
Query: 1104 ESEDEFKISDGSQDEFVVSDENPDESE--EDPPSNDDSDTDFCSRRLRRHPSRPMRQSRR 1161
+SE++ K+ + S+ E V+ +E +E++ E+ ++ + + +
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 1162 LRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDS 1221
K+P + + E+E +++S + + +K + KE++
Sbjct: 499 EETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 558
Query: 1222 ESDGSQKSLRRGK-----EIRRVHKRRLSSSE---------SEESYLSKNSEDDELAKES 1267
+S KS + + E++ K + + E S E S E+ + E+
Sbjct: 559 KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEA 618
Query: 1268 KRSVRKRGRSTDEYSEADEEEE--EEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDS 1325
K V++ +S E ++ + +EE K S ++ E +E +S + A A+
Sbjct: 619 KSPVKEEAKSPAEVKSPEKAKSPTKEEAK-SPEKAKSPEKEEAKSPEKAKSPVKAEAKSP 677
Query: 1326 QPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPST------NGQSPGKA 1379
+ P + E+ K P + +S +E+ ++ K SP+ ++P KA
Sbjct: 678 EKAKSPVKAEA-KSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKA 736
Query: 1380 IENL--IGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDE 1424
+ K EK+++P+ T T +EA +P ++ E
Sbjct: 737 KSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPE 783
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 103 bits (257), Expect = 1e-21
Identities = 224/1120 (20%), Positives = 417/1120 (37%), Gaps = 202/1120 (18%)
Query: 230 LEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKL 289
LE +E K+EE+K +K + + + R + E T KE+ D E V+
Sbjct: 1376 LEPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMT--KEERDMSEEVE- 1432
Query: 290 PVIVKLEKPLPENEEKKIIKEESDSFKENVKPI---KVEVKECRADPKDTKSSMEKPVAQ 346
+ LE+ + + E K ++ E + S+++ K K E R K K EK + Q
Sbjct: 1433 -EMATLEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQ 1491
Query: 347 EPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKS 406
E E++ H+ EK + E E L+ D++ LK E K + ++
Sbjct: 1492 EEEKL---------HQAGEKLSPEEEMLQEDKK----LKWEEWK-----------QVWEN 1527
Query: 407 VTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYE 466
+ +K K++ ++EE ++ G E +Q V E + K I K
Sbjct: 1528 MLSSKS--KEQQYKDEEEVTLEEEVSREGEEKEQQVTEE--QRHIQEEHKWARIHRK--R 1581
Query: 467 TKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPL-RKDADSSISVLEIHSQ 525
+ E ++R + E K + E++ A RK A + + + + +
Sbjct: 1582 ARAEKKRAQEERKLAQEEE------------KLAQEERQLAQEERKLAQAYVKITQDDRE 1629
Query: 526 KAQIEEPDPPEMETSLDSSEMAKDLSSKTA-----LSSTESCTMKGEEKSPKTKKDKRPP 580
AQ E + ET E + K A L+ + EEK K K K
Sbjct: 1630 MAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAK-KGGKLAE 1688
Query: 581 ILECL-EKLEKSKKTFLDKD------AQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSN 633
+ L +K+E+ + + D AQ L + ++ + + + E+ E
Sbjct: 1689 VKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKK 1748
Query: 634 IIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEE 693
+ + E LA ++E + + T + + + E L + E E + L + IE+
Sbjct: 1749 LAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEK 1808
Query: 694 PSETK-------GSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKP 746
+ SM++ ++ +++ A E + E++K + + ++++
Sbjct: 1809 KMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLT 1868
Query: 747 DSPPKVLEPENKQEKTEK-----EEEKTNVGRT-LRRSPRISRPTAKVAEIRDQKADKKR 800
S ++++ +NK K EE+ T T +++ +++ K+ ++ D A K+
Sbjct: 1869 HSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQE 1928
Query: 801 GEGEDEVEEESTALQKTDKKEI-----LKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWK 855
+++++ KK + + K EK N ++ ++ + K+R G+
Sbjct: 1929 KLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEE-KMRLV----EGKET 1983
Query: 856 YSSNDESEGSGSEKSSAASEE--EEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCD 913
S + E S K + +E E + EE IL +D IL + +
Sbjct: 1984 LSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDR-------------ILAMEESE 2030
Query: 914 SGYHTACLRPPLMIIPDGEWFCPPCQHKLLC--EKLEEQLQDLDVALKKKERAERRKERL 971
I G+ KL+ E L ++ L+ LK ++ R + +L
Sbjct: 2031 IAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKL 2090
Query: 972 VYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAID 1031
QEE K K + ERR + + +
Sbjct: 2091 T--------------------QEEIKMTKMKRALFVKERRLSIEQSKL------------ 2118
Query: 1032 EAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRL 1091
DIKE D E+R E + ++ A RK+R+
Sbjct: 2119 -----DIKEWD------------------------FSEKRSELTKDEKKLA--RKQRKLA 2147
Query: 1092 NDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRH 1151
N + N +E+ +E+E K++ E ++ DE EE+ F RR R+
Sbjct: 2148 NKMRRMINKEEKMTEEESKLAR-KHSEVILDDEEEGGIEEEEV------IPFLKRRWRK- 2199
Query: 1152 PSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQ 1211
+ R PK+K+S +E ESEE+ + D+
Sbjct: 2200 ------RKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDEL---------------- 2237
Query: 1212 KRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSV 1271
++Q + + E + ++ R +E+R + R E EE + K E+ + K+
Sbjct: 2238 EKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEE-----KKKKKK 2292
Query: 1272 RKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESC 1311
K+ E E EE+EE + + L E +EEESC
Sbjct: 2293 EKKKEEVQEKEEVFEEKEEIMSEEETESLSD-EEEEEESC 2331
Score = 89.4 bits (220), Expect = 2e-17
Identities = 216/1111 (19%), Positives = 422/1111 (37%), Gaps = 174/1111 (15%)
Query: 198 LAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQ--KESEKMKS 255
L ET +LK + L + N + + EE K +++PKQ + ++ K+
Sbjct: 1360 LEETQVILKKGKKVIFL----EPGNVTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGK 1415
Query: 256 EEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSF 315
++ M E R + +EE + LE+ + + E K ++ E + S+
Sbjct: 1416 IKREMTKEERDMSEEVEE------------------MATLEEKVVKQEGKLVMIERTPSW 1457
Query: 316 KENVK---PIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETE 372
++ K K E R K K EK + QE E++ H+ EK + E E
Sbjct: 1458 QDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKL---------HQAGEKLSPEEE 1508
Query: 373 KLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTIT 432
L+ D++ LK E K + +++ +K K++ ++EE ++
Sbjct: 1509 MLQEDKK----LKWEEWK-----------QVWENMLSSKS--KEQQYKDEEEVTLEEEVS 1551
Query: 433 ALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNS 492
G E +Q V E + K I K + E ++R + E
Sbjct: 1552 REGEEKEQQVTEE--QRHIQEEHKWARIHRK--RARAEKKRAQEERKLAQE--------- 1598
Query: 493 VITSMKTGELEKETA-PLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLS 551
K + E++ A RK A + + + + + AQ E + ET E +
Sbjct: 1599 ---EEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEA 1655
Query: 552 SKTA-----LSSTESCTMKGEEKSPKTKKDKRPPILECL-EKLEKSKKTFLDKD------ 599
K A L+ + EEK K K K + L +K+E+ + + D
Sbjct: 1656 EKLAQKRKKLAKKWEKVAREEEKLAK-KGGKLAEVKNILAQKVEELPQREQNLDWQEKEL 1714
Query: 600 AQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQ 659
AQ L + ++ + + + E+ E + + E LA ++E + + T +
Sbjct: 1715 AQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEE 1774
Query: 660 SVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETK-------GSMQKSKFKYKLVP 712
+ + E L + E E + L + IE+ + SM++ ++
Sbjct: 1775 ELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILY 1834
Query: 713 EEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEK-----EEE 767
+++ A E + E++K + + ++++ S ++++ +NK K EE+
Sbjct: 1835 QKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEK 1894
Query: 768 KTNVGRT-LRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEI---- 822
T T +++ +++ K+ ++ D A K+ +++++ KK +
Sbjct: 1895 LTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGEL 1954
Query: 823 -LKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEE--EEE 879
+ K EK N ++ ++ + K+R G+ S + E S K + +E E +
Sbjct: 1955 DIAKEEKALNLEMKRLAEE-KMR----LVEGKETLSKGETPETSRQRKMTQVEQELFERK 2009
Query: 880 KESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQ 939
EE IL H + IL + + I G+
Sbjct: 2010 LSLEEKILL-------------HEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKAS 2056
Query: 940 HKLL-----CEKLEEQLQDLDVALKKKERAER----------RKERLVYV---GISIE-N 980
KL+ K +L + AL+K R ER + +R ++V +SIE +
Sbjct: 2057 RKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQS 2116
Query: 981 IIPPQEPDFSEDQEEKKKDSKK------SKANLLERRSTRTRKCISYRFDEFDEAIDEAI 1034
+ +E DFSE + E KD KK AN + R + K ++ + E I
Sbjct: 2117 KLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEK-MTEEESKLARKHSEVI 2175
Query: 1035 EDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDL 1094
DD +E GG+ +++ L ++ K +R + K +++++
Sbjct: 2176 LDDEEE---GGI------------EEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEV 2220
Query: 1095 DSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSR 1154
+S+ + EE + D + + +S E +E EE+ ++ + R
Sbjct: 2221 ESEEHFSEEME----SLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGE 2276
Query: 1155 PMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQ 1214
+ + K KKK +E +E EE + E S++ ET ++
Sbjct: 2277 EKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEE------ETESLSDEEEEEES 2330
Query: 1215 INYKEDSESDGSQKSLRRGKEIRRVHKRRLS 1245
+ +E E D ++ L++ K+ + +RR S
Sbjct: 2331 CSLEE--EVDREKEILKKEKQFKLQEQRRKS 2359
Score = 87.8 bits (216), Expect = 7e-17
Identities = 250/1203 (20%), Positives = 449/1203 (37%), Gaps = 203/1203 (16%)
Query: 197 ELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEE--ETPKQEEQKESEKMK 254
EL + + L + VLL++ + P E +E+ + QE + E M
Sbjct: 1285 ELFQEICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQEVIRHKEVMP 1344
Query: 255 SEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDS 314
EE+ + R LEET V +K +K + P V + K + + EEKK ++ S
Sbjct: 1345 REEEQAQKKARDMLG-LEETQVILKK-GKKVIFLEPGNVTMGKEISKKEEKKTFQK---S 1399
Query: 315 FKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKL 374
K+ K ++ E K + + TK + S E+ E +T E + +
Sbjct: 1400 PKQGRKAVQKERKVGKIKREMTKEERDM-----------------SEEVEEMATLEEKVV 1442
Query: 375 KNDQQAKIPLKKREIKLSD-----DFDSPVKGPLCKSVTPTKEFLKDEIKQEEETC---- 425
K Q+ K+ + +R D D V G KS KE + + QEEE
Sbjct: 1443 K--QEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKLHQAG 1500
Query: 426 KRISTITALGHEGKQLVNGE---VSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIIT 482
+++S + E K+L E V + ++ K + + + T EE S +
Sbjct: 1501 EKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEK--- 1557
Query: 483 EGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSL- 541
E TE + K + ++ A K L +K EE + E L
Sbjct: 1558 EQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLA 1617
Query: 542 --------DSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKK--DKRPPILECLEKLEKS 591
D EMA+ + E+ +GE+ S + +K KR + + EK+ +
Sbjct: 1618 QAYVKITQDDREMAQ--AEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVARE 1675
Query: 592 KKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQ 651
++ L K +L+ + K+ L + P+ + +D EKE+ +
Sbjct: 1676 EEK-LAKKGGKLAEV-----KNILAQKVEELPQREQN------LDW-----QEKELAQ-- 1716
Query: 652 STSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLV 711
+LE L+ D E + + L+ + +EE K KL
Sbjct: 1717 -------------ELEELEWDMEELSWKEEELNQEEGKLVEE-------------KKKLA 1750
Query: 712 PEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKE--EEKT 769
EEE A + +++ E K + + I ++K K+ E E + + ++ E+K
Sbjct: 1751 EEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKM 1810
Query: 770 NVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKD 829
+ + R K I QK + + + E+E A +K + +L E+
Sbjct: 1811 KLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRK---ENLLYNKERL 1867
Query: 830 TNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILAD 889
T+SK V+ K K+ G + E EK + ++E+ E+E+ ++
Sbjct: 1868 THSKKQLVQVKNKL--------GMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQV 1919
Query: 890 DDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEE 949
+D KK Q KL EK++
Sbjct: 1920 EDSLAKK------------------------------------------QEKLAQEKMKL 1937
Query: 950 QLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLE 1009
L+ V KK+ R E + I+ E E +++ + + K++ +
Sbjct: 1938 ALEKAMVQGKKRLRGE--------LDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGET 1989
Query: 1010 RRSTRTRKCISYRFDEFDE--AIDEAI---EDDIKEADGGGVGRGKDISTITGHRGKDIS 1064
++R RK + F+ +++E I ED I + + +GK T RG+ I
Sbjct: 1990 PETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFT----RGQRIF 2045
Query: 1065 T-----ILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEF 1119
+ RK K+ + + K + L L + + + +++E K++ + F
Sbjct: 2046 VQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALF 2105
Query: 1120 VVSDENPDESEEDPPSNDDSDTDFCSRR--LRRHPSRPMRQSRRLRRKTPKKKYSDDDEE 1177
V E + D + DF +R L + + R+ R+L K + ++
Sbjct: 2106 VKERRLSIEQSK----LDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMT 2161
Query: 1178 EESEENSRDSESDFSDDFSDDFVETRRR---RSRRNQKRQINYKEDSESDGSQKSLRRGK 1234
EE + +R DD + +E RR +KR K +RG
Sbjct: 2162 EEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKR--------------KEAKRGD 2207
Query: 1235 EIRRVHKRRLSSSESEESYLSK-NSEDDELAK-ESKRSVRKRGRSTDEYSEADE--EEEE 1290
+ + ++ ESEE + + S DEL K ES S + R +E E +E EEEE
Sbjct: 2208 KPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE 2267
Query: 1291 EEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEED 1350
E + ++E +EEE + ++ + E+ +++ SDEEE+
Sbjct: 2268 ERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEE 2327
Query: 1351 FEN 1353
E+
Sbjct: 2328 EES 2330
Score = 70.9 bits (172), Expect = 9e-12
Identities = 143/726 (19%), Positives = 304/726 (41%), Gaps = 108/726 (14%)
Query: 191 IVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKES 250
+ + +LAE +L +++ + + + + LE+ E EE + K+EE +
Sbjct: 1679 LAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQE 1738
Query: 251 E-KMKSEEQPMDLENRSTA---NVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKK 306
E K+ E++ + E + A L E K +E+E + + + + ++ +PE EE++
Sbjct: 1739 EGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPE-EEER 1797
Query: 307 IIKEESDSFKENVKPIKVEVKECRADPKDTKSSM-----------EKPVAQEPERI-EFG 354
+ ++ ++ +K + + + + TK+ M +K +AQE E++ +
Sbjct: 1798 LGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRK 1857
Query: 355 GNIKSSHEITEKSTEETEKLKN--DQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKE 412
N+ + E S ++ ++KN KI L + E KL+ + ++ +K + T K
Sbjct: 1858 ENLLYNKERLTHSKKQLVQVKNKLGMFNKI-LAQVEEKLTQEKETVIKKKEKLAETEKKL 1916
Query: 413 F-LKDEIKQEEETCKRISTITALGH---EGKQLVNGEVSDERVAPNFKTEPIETKFYETK 468
++D + +++E + AL +GK+ + GE+ +A K +E K
Sbjct: 1917 VQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELD---IAKEEKALNLEMK--RLA 1971
Query: 469 EESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQ 528
EE + + +++G E+ K ++E+E + + I + E
Sbjct: 1972 EEKMRLVEGKETLSKGETPETSR----QRKMTQVEQELFERKLSLEEKILLHE------- 2020
Query: 529 IEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKL 588
+ +++ SE+AK K + + ++G+ K K + KL
Sbjct: 2021 -------DRILAMEESEIAK---GKLEFTRGQRIFVQGQRKLAKASR-----------KL 2059
Query: 589 EKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVV 648
K K+ L K+ +L+ I + + K T + K E T + +L+ E+ +
Sbjct: 2060 IK-KRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKL 2118
Query: 649 ECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKY 708
+ +K+ D ++ SE TK D + + + K +K +
Sbjct: 2119 D-----------IKEWDFS--EKRSELTK------DEKKLARKQRKLANKMRRMINK-EE 2158
Query: 709 KLVPEEETTASENTEITSERQKEG----------IKLTIRISSRKKKPDSPPKVLEPENK 758
K+ EE A +++E+ + ++EG +K R K+ D P + +
Sbjct: 2159 KMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVD 2218
Query: 759 QEKTEK--EEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQK 816
+ ++E+ EE ++ L + +S + E +++ +++ E E+E +EE +K
Sbjct: 2219 EVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEK 2278
Query: 817 TDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEE 876
+KE +K +K K +V+ K +V ++ E E++ + S+E
Sbjct: 2279 QVEKEEEEKKKKKKEKKKEEVQEKEEV--------------FEEKEEIMSEEETESLSDE 2324
Query: 877 EEEKES 882
EEE+ES
Sbjct: 2325 EEEEES 2330
Score = 68.6 bits (166), Expect = 4e-11
Identities = 152/717 (21%), Positives = 298/717 (41%), Gaps = 102/717 (14%)
Query: 169 QDHNVRMYIEEQD-DQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRES 227
Q+ + +EE + D + SWK N+ E ++ K + +++ + +
Sbjct: 1710 QEKELAQELEELEWDMEELSWKEEELNQEE---------GKLVEEKKKLAEEEEALAWQR 1760
Query: 228 PSLEDEETK--KEEETPKQEEQK---ESEKMKSEEQPMDLENRSTANVLEETTVKKEK-- 280
L +EETK +EEE QE++K EKM EE+ + + + K+E+
Sbjct: 1761 EKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWI 1820
Query: 281 EDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSF---KENVKPIKVEVKECRADPKDTK 337
+EL K +I+ +K L + EKK + +E + KEN+ K + + K
Sbjct: 1821 NSMEELTKNKMILYQKKNLAQ--EKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVK 1878
Query: 338 SSM---EKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDD 394
+ + K +AQ E++ + + +K + E K Q + L K++ KL+ +
Sbjct: 1879 NKLGMFNKILAQVEEKLT-----QEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQE 1933
Query: 395 FDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDER---- 450
+K L K++ K+ L+ E+ +E + L E +LV G+ + +
Sbjct: 1934 ---KMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETP 1990
Query: 451 -VAPNFKTEPIETKFYETK---EESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKET 506
+ K +E + +E K EE +DR + E + T + ++ +
Sbjct: 1991 ETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQ- 2049
Query: 507 APLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKG 566
RK A +S +++ +++ +EP +++ K L + L+ E +
Sbjct: 2050 ---RKLAKASRKLIK--KRESLSKEP-----------AKLNKILKALQKLTRDERKLTQE 2093
Query: 567 EEKSPKTK-----KDKRPPI----LECLEKLEKSKKTFLDKDAQRLS----PIPEEVPKS 613
E K K K K++R I L+ E K++ L KD ++L+ + ++ +
Sbjct: 2094 EIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRM 2153
Query: 614 TLESEKPGSPEAAETSPPSNII--DHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKE 671
+ EK E+ S +I D E E+EV+ + K+ D K
Sbjct: 2154 INKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKF 2213
Query: 672 DSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKE 731
S+ +VE + + + + + E + S+ + EEE E E R++E
Sbjct: 2214 SSQVDEVESEEHFSEEMESLLDELEKQESLSSEE-------EEEREEEEEREEEEVREEE 2266
Query: 732 GIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEI 791
RK++ + K +E E +++K +K+E+K + +V E
Sbjct: 2267 --------EERKEEEEGEEKQVEKEEEEKKKKKKEKKKEE----------VQEKEEVFEE 2308
Query: 792 RDQKADKKRGE--GEDEVEEESTALQK--TDKKEILKKSEKDTNSKVSKVKPKGKVR 844
+++ ++ E ++E EEES +L++ +KEILKK ++ + + +G+ R
Sbjct: 2309 KEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRER 2365
Score = 42.4 bits (98), Expect = 0.003
Identities = 50/192 (26%), Positives = 92/192 (47%), Gaps = 36/192 (18%)
Query: 225 RESPSLEDEETKKEEETPKQEEQ--KESEKMKSEEQPMDLENRSTANVLEETTVKKEKED 282
+ES S E+EE ++EEE ++EE+ +E E+ K EE+ EE V+KE+E+
Sbjct: 2240 QESLSSEEEEEREEEEE-REEEEVREEEEERKEEEEG------------EEKQVEKEEEE 2286
Query: 283 EKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKS--SM 340
+K+ K ++K+ ++E+ + F+E + + E E +D ++ + S+
Sbjct: 2287 KKKKKK-------------EKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSL 2333
Query: 341 EKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVK 400
E+ V +E E ++ K E KS E++ + + K R I+L +K
Sbjct: 2334 EEEVDREKEILKKEKQFK-LQEQRRKSLRGRERVLSILRGVPHGKGRAIRL-----GVLK 2387
Query: 401 GPLCKSVTPTKE 412
PL K ++ E
Sbjct: 2388 SPLKKLMSTALE 2399
Score = 42.0 bits (97), Expect = 0.004
Identities = 152/806 (18%), Positives = 298/806 (36%), Gaps = 137/806 (16%)
Query: 692 EEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPK 751
EEP + M+ + + L + E +EN ++ +K L + + S K PP
Sbjct: 1009 EEPLDHLLGMRATDLQI-LSTQVEQRLNENLTLSHRDEKPAFSLDVSMPSELKSSLKPPT 1067
Query: 752 VLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDE----- 806
V E K K + + G + S + R K E ++ + G EDE
Sbjct: 1068 VSEESEVAIKPSKGQRRGQAG-VKKHSQKWLRGLKKTKERDSKQMSTEPGLLEDESGTEA 1126
Query: 807 ----VEEESTALQKTDKKEILKKS------EKD--------TNSKVSKVKPKGKVRWTGS 848
+EE S Q + ++K S EKD T ++ K++ K + T
Sbjct: 1127 APIEMEEASVYSQWSSSTSVIKLSKDVDSQEKDISKDHIALTLKRLQKIRDKRDKKATAQ 1186
Query: 849 RTRGRWKYSSNDESEGSGSEKSSAASEEEEEKE-----------SEEAILADD-----DE 892
+ + + K E++ E + E+ K+ S A D D+
Sbjct: 1187 KLKKKHK-KKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRSTAGDGSSWRDD 1245
Query: 893 PCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQ 952
C+ L + ++ ++ T + P E F C LL ++ + L+
Sbjct: 1246 LCRLMALRISGSQTKMSENLNAELVTFAQEMLVDRHPSWELFQEICP--LLKKESKVLLE 1303
Query: 953 DLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQE----EKKKDSKKSKANL- 1007
DLD + E+ K + G E++I + +E E+++ KK++ L
Sbjct: 1304 DLDWDVVPPEK----KPIFIQEGAIREDMIQGVTQEVIRHKEVMPREEEQAQKKARDMLG 1359
Query: 1008 LERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTIL 1067
LE +K F E G V GK+IS
Sbjct: 1360 LEETQVILKKGKKVIFLE-----------------PGNVTMGKEISK------------- 1389
Query: 1068 DEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPD 1127
EE+K ++ + +K R++ + + +E + +E + + +E VV E
Sbjct: 1390 KEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVE-EMATLEEKVVKQEGKL 1448
Query: 1128 ESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDS 1187
E PS D + + +R + + + + K+ ++++ ++ E
Sbjct: 1449 VMIERTPSWQDWKKAWDEWKQVHGETR--KSWKAWKEEWEKRLLQEEEKLHQAGEKLSPE 1506
Query: 1188 ESDFSDDFSDDFVETRR--RRSRRNQKRQINYKEDSESDGSQKSLRRGKEIR-------- 1237
E +D + E ++ ++ ++ YK++ E ++ R G+E
Sbjct: 1507 EEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQR 1566
Query: 1238 ---------RVHKRRLSSSE---SEESYLSKNSEDDELAKESKRSVRKRGRSTDEY---S 1282
R+H++R + + EE L++ E+++LA+E ++ ++ + Y +
Sbjct: 1567 HIQEEHKWARIHRKRARAEKKRAQEERKLAQ--EEEKLAQEERQLAQEERKLAQAYVKIT 1624
Query: 1283 EADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR 1342
+ D E + EGK ++K EE+ +Q A ++ ++ KK +
Sbjct: 1625 QDDREMAQAEGKFAQK---------EETLAQRGEKLSQEAE----KLAQKRKKLAKKWEK 1671
Query: 1343 IESDEEEDFENVGK---VGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNST 1399
+ +EE+ + GK V + L + +LP +NL + E +Q ++
Sbjct: 1672 VAREEEKLAKKGGKLAEVKNILAQKVEELPQRE--------QNLDWQEKELAQELEELEW 1723
Query: 1400 ASASLASNGTSGGQEAGAPEEEEDEL 1425
L+ QE G EE+ +L
Sbjct: 1724 DMEELSWKEEELNQEEGKLVEEKKKL 1749
>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens]
Length = 1341
Score = 102 bits (253), Expect = 3e-21
Identities = 258/1289 (20%), Positives = 477/1289 (37%), Gaps = 198/1289 (15%)
Query: 166 QLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQ-IDPVLLKNSSQQD-NS 223
++ Q+ ++ Y+E+Q + + R EL E A + + I P + + D S
Sbjct: 130 EMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQS 189
Query: 224 SRESPSLEDEETKKEEETPKQEEQKES--EKMKSEEQPMDLENRSTANVLEETTVKKEKE 281
S E P LE + + EE+ +S EK + E+ ++ A L E + E+E
Sbjct: 190 SLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEE 249
Query: 282 DEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKE----------NVKPIKVEVKE--- 328
+++E + V+ ++ L EE++ +EE + +E PI E KE
Sbjct: 250 EDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGE 309
Query: 329 --CRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPL-- 384
R P++ K +QE E +E GG S E KS ++ + + + PL
Sbjct: 310 EIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEE 369
Query: 385 KKREIKLSDDFDSPVKGPLCKSVTPTKE-----FLKDEIKQEEETCKRISTITALGHEGK 439
++REIK S K P +T ++ L ++ EEET
Sbjct: 370 EEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEET-------------PP 416
Query: 440 QLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNI-ITEGNGTESLNSVITSMK 498
L+ E S P +E E E P+ I ++ N ++ S
Sbjct: 417 PLLTKEASSPPPHPQLHSE-------EEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQH 469
Query: 499 TGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSS 558
T +L +PL +D+ E ++K E P +++L KDL ++ S
Sbjct: 470 TVQLVGGLSPLSSPSDTK---AESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESD-RS 525
Query: 559 TESCTMKGEEKSPK---TKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTL 615
+ +K EE + T++ + P LE E ++ T L + RL + +
Sbjct: 526 AQPLPLKIEELALAKGITEECLKQPSLEQKEG-RRASHTLL--PSHRLKQSADSSSSRSS 582
Query: 616 ESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSV--KKVDLETLKEDS 673
S S + + S H + +++V + ++ + G+ + E+
Sbjct: 583 SSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSR 642
Query: 674 EFTKVEMDNLDNAQTSGIEEPS-----ETKGSMQKSKFKYKLVPE------EETTASENT 722
++ N + + G+ S ETK + VP+ +E T++ ++
Sbjct: 643 SRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSS 702
Query: 723 EITSER--QKEGIK--LTIRISSRKKKPD-------SPPKVLEPENKQEKTEKEEEKTNV 771
+ + R Q E + +T R+ + P PP +P+ + +T E +
Sbjct: 703 SVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERI 762
Query: 772 GRTLRRSPRI------SRPTAKVAE----IRDQKADKKRGEG--EDEVEEESTALQKTDK 819
T+ + +RP V E I DQ ++ R EG EDE ++ES +L K+ K
Sbjct: 763 HHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKES-SLPKSFK 821
Query: 820 KEI----LKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGS----EKSS 871
++I K NS +P K RW S + K S + +E S K
Sbjct: 822 RKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPL 881
Query: 872 AASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDG 931
A E + ++++ +++D+ + D G H L+
Sbjct: 882 AGQEAVVDLHADDSRISEDETE----------------RNGDDGTHDKGLK--------- 916
Query: 932 EWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSE 991
C + E E ++ +++E E E V +S+E +PP
Sbjct: 917 --ICRTVTQVVPAEGQENGQRE-----EEEEEKEPEAEPPVPPQVSVEVALPP-----PA 964
Query: 992 DQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGK- 1050
+ E KK + T TR+ IS + + I+D ++ A RGK
Sbjct: 965 EHEVKK----------VTLGDTLTRRSISQQ----KSGVSITIDDPVRTAQVPSPPRGKI 1010
Query: 1051 ----------------DISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDL 1094
+ + G G T+++E +K +
Sbjct: 1011 SNIVHISNLVRPFTLGQLKELLGRTG----TLVEEAFWIDKIKSHCFVTYSTVEEAVATR 1066
Query: 1095 DSDSNLDEEESEDEFKISD-GSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPS 1153
+ + +S +F +D QDE + D PS ++ R L P
Sbjct: 1067 TALHGVKWPQSNPKFLCADYAEQDEL----DYHRGLLVDRPSETKTEEQGIPRPLHPPPP 1122
Query: 1154 RPM------RQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRS 1207
P+ R +R + + ++++++ + E E E +R D + R R
Sbjct: 1123 PPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRD 1182
Query: 1208 RRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSS------SESEESYLSKNSEDD 1261
RR ++R + ++ SE + K + + ++ ++ ++ + K +E
Sbjct: 1183 RRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERA 1242
Query: 1262 ELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKP---SRKRLHRIETDEEESCDNA--HG 1316
E AKE R R++ + +E E ++E E E + ++R H E D E + G
Sbjct: 1243 ERAKE--REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRG 1300
Query: 1317 DANQPARDSQPRVLPSEQESTKKPYRIES 1345
D ++ + R ++ TK+ R S
Sbjct: 1301 DRDRDRERDRERGRERDRRDTKRHSRSRS 1329
Score = 53.1 bits (126), Expect = 2e-06
Identities = 71/308 (23%), Positives = 116/308 (37%), Gaps = 48/308 (15%)
Query: 1156 MRQSRRLRRKTPKKKYSDDDEEEESEENSRDS-------ESDFSDDFSDDFVETRRRRSR 1208
+ + + L R+ +++ + E EE+ S D S DF SR
Sbjct: 141 LEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSR 200
Query: 1209 RNQKRQINYKE---DSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAK 1265
+ ++ + E DS+ + +K RR +R+ +LS E S ++ ED E
Sbjct: 201 HSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLS----EGSQPAEEEEDQETPS 256
Query: 1266 ESKRSVRKRGRSTDEYSEADEEEEE--------EEGKPSRKRLHRIETDEEESCDNAHGD 1317
+ R R T+E E +EEEEE +EG+ SR+ I + +E +
Sbjct: 257 RNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREA--PILKEFKEEGEEIPRV 314
Query: 1318 ANQPARDSQPRVLPSEQESTKKPYRIESDEEE---------DFENVGKVGSPLDYSLVDL 1368
+ D +P+ EQE ++ R +EE E K SPL+ ++
Sbjct: 315 KPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREI 374
Query: 1369 PSTNG-------QSPGKAIE-----NLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAG 1416
S+ G SP + E +L+ P QT + T L +S
Sbjct: 375 KSSQGLKEKSKSPSPPRLTEDRKKASLVALP---EQTASEEETPPPLLTKEASSPPPHPQ 431
Query: 1417 APEEEEDE 1424
EEE E
Sbjct: 432 LHSEEEIE 439
Score = 48.9 bits (115), Expect = 3e-05
Identities = 72/344 (20%), Positives = 137/344 (39%), Gaps = 45/344 (13%)
Query: 1098 SNLDEE--ESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRP 1155
S++ EE +S+DE + V SE P+ ++ D + SR LR
Sbjct: 207 SSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLR------ 260
Query: 1156 MRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDD--FSDDFVETRRRRSRRNQKR 1213
+R R L KT +++ +++EEE+ EE D E S + +F E R +
Sbjct: 261 VRADRNL--KTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEE 318
Query: 1214 QINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRK 1273
++ + + S Q+ L RG R S E+ +S+L++ ++ E+
Sbjct: 319 MMDERPKTRSQ-EQEVLERGGRFTR------SQEEARKSHLARQQQEKEM---------- 361
Query: 1274 RGRSTDEYSEADEEEEEEEGKPSRKRL---HRIETDEEESCDNAHGDANQPARDSQPRVL 1330
++T E + E + +G + + R+ D +++ A + ++ P +L
Sbjct: 362 --KTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLL 419
Query: 1331 PSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEK 1390
E S ++ S+EE + + P L+ L N + + E L+ + T +
Sbjct: 420 TKEASSPPPHPQLHSEEE-----IEPMEGPAPPVLIQLSPPNTDADTR--ELLVSQHTVQ 472
Query: 1391 SQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDY 1434
+ S S+ + PEE L++ + L DY
Sbjct: 473 LV----GGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADY 512
Score = 37.4 bits (85), Expect = 0.11
Identities = 35/192 (18%), Positives = 70/192 (36%), Gaps = 24/192 (12%)
Query: 1128 ESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDS 1187
E E + S+ ++ ++R P R R R++ K K +++E+++E +
Sbjct: 1150 EREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQE---EP 1206
Query: 1188 ESDFSDDF----------------SDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLR 1231
+ DD V+ R+ R ++R+ KE E + ++
Sbjct: 1207 PAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKE 1266
Query: 1232 ----RGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEE 1287
R +++ R +R S E + + + ++ +R R+RGR D
Sbjct: 1267 AERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERD-RERGRERDRRDTKRHS 1325
Query: 1288 EEEEEGKPSRKR 1299
P R R
Sbjct: 1326 RSRSRSTPVRDR 1337
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 98.6 bits (244), Expect = 4e-20
Identities = 209/1224 (17%), Positives = 465/1224 (37%), Gaps = 210/1224 (17%)
Query: 213 LLKNSSQQDNSSRESP---SLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTAN 269
LL++ Q+++ R P LE+E ++ + +++E++ +E + E+ LE R
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168
Query: 270 VLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKEC 329
EE ++++ E+E E+ E + + E++ F + + + E+ E
Sbjct: 169 RDEELWRQRQEWQERE----------ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL 218
Query: 330 RADPKDTKSSMEKP----VAQEPERIEFGGNI----KSSHEITEKSTEETEKLKNDQQAK 381
R ++ K + V QE E E+ K ++ E+ + +L+ +++
Sbjct: 219 RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL 278
Query: 382 IPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQL 441
L+++E++ + + L + ++ ++ +Q+EE ++ +Q
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQ 338
Query: 442 VNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGE 501
+ E + R + + E + + + E +++ + E + L + +
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE----QQLRREQQLRREQQ 394
Query: 502 LEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTES 561
L +E LR++ Q+ + E+ E E + ++ + E
Sbjct: 395 LRREQQ-LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Query: 562 CT--MKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEK 619
+K EE++ + ++++R L+ ++ E+ ++ ++ +R + E E+
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513
Query: 620 PGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVE 679
+ ++L SE+++ Q E L + E ++E
Sbjct: 514 RREQRLKRQEEEERLQ---QRLRSEQQLRREQEERR-----------EQLLKREEEKRLE 559
Query: 680 MDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRI 739
+ + EE + ++ + + +L E+E + + + E ++ R
Sbjct: 560 QERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK---REEVERLEQEERR 616
Query: 740 SSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADK- 798
R K+ + E E +Q+ + EE++ + LRR + R E +++ ++
Sbjct: 617 EQRLKREEP-----EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671
Query: 799 -KRGEGEDEVEEESTALQKTDKKEILKKS--------EKDTNSKVSKVKPKGKVRWTGSR 849
KR E+ E+E ++ +E +K E + +++ SKV + + + R
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731
Query: 850 TRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLC 909
+ + + ESE E+ A +++EE++ + E
Sbjct: 732 RQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE----------------- 774
Query: 910 DSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKE 969
+ + G RPPL E+ E QL RAE R++
Sbjct: 775 EKSERGRQRLSARPPLR------------------EQRERQL-----------RAEERQQ 805
Query: 970 RLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEA 1029
R + +P +E ++Q +++ ++ + LE R+ + + E ++
Sbjct: 806 RE-------QRFLPEEE---EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855
Query: 1030 IDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRR 1089
+ E E + R + L+EERK + A A +++ R
Sbjct: 856 LQEDQERRRSQEQ---------------RRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 1090 RLNDL--DSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRR 1147
+ L + + L EE E + + E +E + EE+ ++ + +R
Sbjct: 901 KEQQLLQEEEEELQREEREKRRR----QEQERQYREEEQLQQEEEQLLREERE-----KR 951
Query: 1148 LRRHPSRPMRQSRRL---------------RRKTPKKKYSDDDEEEESEENSRDSESDF- 1191
R+ R R+ ++L RR+ +KKY +++E ++ EE E +
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 1192 -----------SDDFSDDFVETRR--RRSRRNQKRQINYKEDSESD-------GSQKSLR 1231
D+ + + R R RR Q+R+ Y+E+ E G ++ R
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Query: 1232 RGKEIRRVHKRRLSSSESEESYLSKN-------------SEDDELAKE------SKRSVR 1272
R +E+ R +++ + EE L + E++EL +E +R R
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131
Query: 1273 KRGRSTDEYSEADEEEEEEE----GKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPR 1328
+R +Y E +E ++EEE +P ++R +E E + + + +
Sbjct: 1132 RRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE---------EEELQQEEEQ 1182
Query: 1329 VLPSEQESTKKPYRIESDEEEDFE 1352
+L EQE ++ + EEE+ +
Sbjct: 1183 LLREEQEKRRQERERQYREEEELQ 1206
Score = 97.1 bits (240), Expect = 1e-19
Identities = 196/1168 (16%), Positives = 460/1168 (39%), Gaps = 145/1168 (12%)
Query: 214 LKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEE 273
LK ++ ++ E++E +++++ ++++++ +++K EE+ LE R
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR-------- 671
Query: 274 TTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVK---PIKVEVKECR 330
+K+E E+E+ E+++ +EE + +E +K P E
Sbjct: 672 --LKREHEEER------------------REQELAEEEQEQARERIKSRIPKWQWQLESE 711
Query: 331 ADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIK 390
AD + +K +P QE +R E EK +L+ ++ + +++E +
Sbjct: 712 ADARQSK-VYSRPRKQEGQR--------RRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Query: 391 LSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDER 450
DF T ++ +E + E +R+S L + ++ + E +R
Sbjct: 763 QRRDF--------------TWQWQAEE--KSERGRQRLSARPPLREQRERQLRAEERQQR 806
Query: 451 VAPNFKTEPIETKFYETKEESYSPSKD-RNIITEGNGTESLNSVITSMKTGELEKETAPL 509
E +F +EE + R E E + + +L++E L
Sbjct: 807 ----------EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856
Query: 510 RKDADSSISVLEIHSQK--AQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGE 567
++D + S + QK Q+EE T + + L + L E ++ E
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 568 EKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAE 627
E+ + ++++ E E+L++ ++ L ++ ++ E + + +
Sbjct: 917 EREKRRRQEQERQYRE-EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 628 TSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQ 687
P EK E+E ++ + + + K+ +++ E + D L +
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR-----RRQEWERQYRKKDELQQEE 1030
Query: 688 TSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPD 747
+ E E K +Q+ + +Y+ EEE E ++ E ++ +R+++
Sbjct: 1031 EQLLREERE-KRRLQERERQYR---EEEELQQEEEQLLGEERE----------TRRRQ-- 1074
Query: 748 SPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEV 807
++ K+E+ ++EEE + LR P R + + R+++ ++ E
Sbjct: 1075 ---ELERQYRKEEELQQEEE-----QLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126
Query: 808 EEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGS 867
E E Q+ +++ ++ + ++ + +P+ R R + +E E
Sbjct: 1127 EREKRRRQELERQYREEEEVQQEEEQLLREEPE-------KRRRQELERQYREEEELQQE 1179
Query: 868 EKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMI 927
E+ E+E+ ++ E +++E ++ + + + S
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRD-----EDQRSDLKWQWEPEKENA 1234
Query: 928 IPDGEWFCPPCQHKLLCEKLEEQL------QDLDVALKKKERAERRKERLVYVGISIENI 981
+ D + +C +++ + + QL QDL L +++ +R +ER + +
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ--QRDRH 1292
Query: 982 IPPQEPDFSEDQEEKKKDSKKS--KANLL--ERRSTRTRKCISYRFDEFDEAIDEAIEDD 1037
P +E E+Q+E K+ +KS + LL ER R R+ +F E ++ + E E
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Query: 1038 IKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSD 1097
++ + R +++ + L+EE++ ++ + + +++ R + +
Sbjct: 1353 LRRQERDRKFREEEL-----RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407
Query: 1098 SNLDEEES--EDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRP 1155
D + E+E ++S +D +E +E + + R R+
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467
Query: 1156 M----RQSRRLRRKTPKKKYSDDDEEEESEENSRD--SESDFSDDFSDDFVETRRRRSRR 1209
R+ ++L R+ +K+ +++++ +E R + S + F+E ++ R+
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527
Query: 1210 NQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKR 1269
++R+ +E + RR R+ + E EE LS+ D + E ++
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587
Query: 1270 SVRKRGRSTDEYSEADEEEEEEEGKPS--RKRLHRIETDEEESCDNAHGDANQPARD--- 1324
+R ++ E +++ +EG+ ++R + DE+ + ++ RD
Sbjct: 1588 V--RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 1325 --SQPRVLPSEQESTKKPYRIESDEEED 1350
+P++ E+E + R EE+
Sbjct: 1646 LEEEPQLRRQEREQQLRHDRDRKFREEE 1673
Score = 92.0 bits (227), Expect = 4e-18
Identities = 193/1113 (17%), Positives = 428/1113 (38%), Gaps = 131/1113 (11%)
Query: 215 KNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEET 274
K +++ R E++E +K E ++EE+K E+ ++ + E + +
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 275 TVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPK 334
++ +E+E++ +L +L + + EE++ +EE +E + + ++ +
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRK--QEEERREQQEERREQQERREQQEERREQQLRREQ 343
Query: 335 DTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDD 394
+ + + QE ER E + E E+ ++L+ +QQ + RE +L +
Sbjct: 344 EERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR-----REQQLRRE 398
Query: 395 FDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPN 454
+ + ++ +++ + E+ +R +Q + E +ER
Sbjct: 399 ----------QQLRREQQLRREQQLRREQQLRR-----------EQQLRREQEEERHEQK 437
Query: 455 FKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDAD 514
+ E E + +EE K R TE + E + + E E+ L+ + +
Sbjct: 438 HEQERREQRLKREQEERRDWLK-REEETERHEQERRKQQLK--RDQEEERRERWLKLEEE 494
Query: 515 SSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTK 574
E Q+ + E+ + E L E + L + ++ E++ + +
Sbjct: 495 ERREQQERREQQLRREQEE--RREQRLKRQEEEERLQQR----------LRSEQQLRREQ 542
Query: 575 KDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNI 634
+++R +L K E+ K+ ++ QRL EE L+ E+ + + +
Sbjct: 543 EERREQLL----KREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERL 598
Query: 635 IDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEP 694
++ E+ E + + + ++ + L + E + L Q E+
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 695 SETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTI---------RISSRKKK 745
+ + ++ + + K EEE E E E+ +E IK I +R+ K
Sbjct: 659 LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718
Query: 746 PDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRD----QKADKKRG 801
S P+ E + ++++ E++ + + R R + + RD +A++K
Sbjct: 719 VYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSE 778
Query: 802 EGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDE 861
G + L++ ++++ + + + + + + R R R + +E
Sbjct: 779 RGRQRLSARPP-LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE 837
Query: 862 SEGSGSEKSSAASEEEEE-KESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTAC 920
+ E++ EEE+ +E +E + + +K E HT
Sbjct: 838 EQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER-------KRRRHTLY 890
Query: 921 LRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIEN 980
+P L Q +L K ++ LQ+ + L+++ER +RR++
Sbjct: 891 AKPAL-------------QEQL--RKEQQLLQEEEEELQREEREKRRRQE---------- 925
Query: 981 IIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKE 1040
QE + E+++ ++++ + + +RR + YR D+ + +E + + E
Sbjct: 926 ----QERQYREEEQLQQEEEQLLREEREKRRRQERER--QYRKDKKLQQKEEQLLGEEPE 979
Query: 1041 ADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNL 1100
R ++ EE + + ++ R+KRRR
Sbjct: 980 K----------------RRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 1101 DEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDT-DFCSRRLRRHPSRPMRQS 1159
DE + E+E + + + + E EE+ ++ + R R+ R R+
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKE 1083
Query: 1160 RRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKE 1219
L+++ ++ ++ E+ +E R + ++ + R RR Q+ + Y+E
Sbjct: 1084 EELQQEE-EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE 1142
Query: 1220 DSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTD 1279
+ E ++ L R KRR E E Y E++EL +E ++ +R+
Sbjct: 1143 EEEVQQEEEQLLR----EEPEKRR--RQELERQY----REEEELQQEEEQLLREEQEKRR 1192
Query: 1280 EYSEADEEEEEEEGKPSRKRLHRIETDEEESCD 1312
+ E EEEE + RK+ +R DE++ D
Sbjct: 1193 QERERQYREEEELQRQKRKQRYR---DEDQRSD 1222
Score = 86.3 bits (212), Expect = 2e-16
Identities = 212/1261 (16%), Positives = 475/1261 (37%), Gaps = 133/1261 (10%)
Query: 156 RDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLK 215
R ++ + W + ++ H + +E++ + +W+ ++E + + +
Sbjct: 740 RRRESELQWQEEERAHRQQ---QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER 796
Query: 216 NSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETT 275
++ RE L +EE K++ ++E +KE + ++ EEQ L+ R A L+E
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ---LQRRERAQQLQEEE 853
Query: 276 VKKEKEDEKE-------------------------LVKLPVI---VKLEKPLPENEEKKI 307
+++ E+ L P + ++ E+ L + EE+++
Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913
Query: 308 IKEESDSFK--ENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITE 365
+EE + + E + + E + + + + + EK QE ER ++ + K + +
Sbjct: 914 QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER-QYRKDKKLQQKEEQ 972
Query: 366 KSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLK-DEIKQEEET 424
EE EK + ++ K ++ E++ ++ + + +++ K DE++QEEE
Sbjct: 973 LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032
Query: 425 CKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYET------KEESYSPSKDR 478
R E ++ E ++ E ET+ + KEE +++
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092
Query: 479 NIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEME 538
+ E + EL++E L ++ E+ Q + EE E +
Sbjct: 1093 LLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQ 1152
Query: 539 TSLDS------SEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSK 592
+ E+ + + L E ++ E++ + +++++ E L++ +K K
Sbjct: 1153 LLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR-QKRK 1211
Query: 593 KTFLDKDAQ-----RLSPIPEEVPKSTL------ESEKPGSPEAAETSPPSNIIDHCEKL 641
+ + D+D + + P E + E+E+ E ++ + D L
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 642 ASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSM 701
++E Q + + E L+ + + D + + E E K
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 702 QKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEK 761
Q++ K++ EEE E E RQ+ K + + K LE E + +
Sbjct: 1332 QETDRKFR---EEEQLLQEREEQPLRRQERDRKFR---EEELRHQEQGRKFLEEEQRLRR 1385
Query: 762 TEKEEEKTNVGRTLR--------RSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTA 813
E+E + + LR R R + + ++ Q+ D+K E E +V +
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Query: 814 LQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAA 873
+ ++++ L++ + ++ + + + + R R K+ ++
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR-KFLEEEQQLRRQERDRKFR 1504
Query: 874 SEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEW 933
+E +E E L ++ + ++ + + G R
Sbjct: 1505 EQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE----- 1559
Query: 934 FCPPCQHKLLCEKLEEQL--QDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSE 991
+ +L E+ E+QL Q+ D + +E+ RR+E QE F E
Sbjct: 1560 -----EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE---------------QERKFME 1599
Query: 992 DQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKD 1051
D+++ ++ + + R R RK F E ++ + E E + + ++
Sbjct: 1600 DEQQLRRQEGQQQL-----RQERDRK-----FREDEQLLQEREEQQLHRQERDRKFLEEE 1649
Query: 1052 ISTITGHRGKDISTILDEERKENKRPQRAAAAR--RKKRRRLNDLDSDSNLDEEESEDEF 1109
R + + D + +E ++ + + R++ R + + L +E E +F
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709
Query: 1110 KISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRR------LRRHPSRPMRQSRRLR 1163
+++ + E + E+ +++ + R+ L RP R+ ++LR
Sbjct: 1710 L----QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLR 1765
Query: 1164 RKTPKKKYSDDDE--EEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDS 1221
R+ +K+ ++++ +E E+ R ESD + + R + R Q+R Y+ +
Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEE 1825
Query: 1222 ESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDEL--AKESKRSVRKRGRSTD 1279
E ++ +R +R+ R+ + E + E+ EL +E KR + + +
Sbjct: 1826 EQLQLEEQEQR---LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLRE 1882
Query: 1280 EYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKK 1339
E+ ++EE+ + + + H A+ P R S EQ S +
Sbjct: 1883 EHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQYR 1942
Query: 1340 P 1340
P
Sbjct: 1943 P 1943
Score = 77.0 bits (188), Expect = 1e-13
Identities = 111/633 (17%), Positives = 246/633 (38%), Gaps = 98/633 (15%)
Query: 730 KEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEK-EEEKTNVGRTLRRSPRISRPTAKV 788
KE + R +++ + + LE E Q + +K +E++ + +S + R +
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 789 AEIRDQKADKKRGEGEDE----VEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVR 844
+ RD++ ++R E ++ EEE K + E E+ ++ +++ KG+
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGR-- 223
Query: 845 WTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKE--SEEAILADDDEPCKKCGLPNH 902
+E + E+ +EEEEKE E +L ++E ++
Sbjct: 224 ---------------EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 903 PELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKE 962
EL ++ EEQL+ L+ +++
Sbjct: 269 REL---------------------------------------QEEEEQLRKLE---RQEL 286
Query: 963 RAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYR 1022
R ER++E + E + ++ + +Q+E++++ ++ + ERR + R+
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR----- 341
Query: 1023 FDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAA 1082
E +E ++ + + +E R + + +EER+E + +
Sbjct: 342 --EQEERREQQLRREQEEE----------------RREQQLRREQEEERREQQLRREQQL 383
Query: 1083 ARRKKRRRLNDLDSDSNLDEEES---EDEFKISDGSQDEFVVSDENPDESEEDPPSNDDS 1139
R ++ RR L + L E+ E + + + E + E +E E +
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR 443
Query: 1140 DTDFC-SRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDD 1198
+ + RR + ++ R ++ K++ D EEE E + E + +
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Query: 1199 FVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSS--SESEESYLSK 1256
+ RR + R ++R K E + Q+ LR +++RR + R EE L +
Sbjct: 504 EQQLRREQEERREQR---LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQ 560
Query: 1257 NSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHG 1316
+ L +E + + + +E + + E+EE R + +E E+E
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Query: 1317 DANQPARDSQPRVLPSEQESTKKPYRIESDEEE 1349
+P + + ++L SE++ ++ ++ +++E
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQE 653
Score = 55.8 bits (133), Expect = 3e-07
Identities = 138/802 (17%), Positives = 303/802 (37%), Gaps = 134/802 (16%)
Query: 96 QEFNSTWAWEMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIG 155
Q + W WE EK+ A+ C+ +N +F+ + ED+
Sbjct: 1219 QRSDLKWQWEPEKEN----------AVRDNKVYCKGRENEQFRQL---EDSQL------- 1258
Query: 156 RDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLK 215
RD+ Q D H + E +Q+ W+ R+ E + L+
Sbjct: 1259 RDRQS-----QQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ-------------LE 1300
Query: 216 NSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETT 275
Q++ R+ S E+++ +EE K+ Q+ K + EEQ L+ R EE
Sbjct: 1301 REEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL--LQER------EEQP 1352
Query: 276 VKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKD 335
+++++ D K + E+ + + +K ++EE + ++ + E K + + +
Sbjct: 1353 LRRQERDRK--------FREEELRHQEQGRKFLEEE-----QRLRRQERERKFLKEEQQL 1399
Query: 336 TKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDF 395
E+ + Q+ +R K E + S +E ++ +++ ++ ++RE K ++
Sbjct: 1400 RCQEREQQLRQDRDR-------KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEE- 1451
Query: 396 DSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNF 455
+ ++ + ++ L++ +EE+ R E +QL E +
Sbjct: 1452 EQQLRQERHRKFREEEQLLQE---REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL 1508
Query: 456 KTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELE-KETAPLRKDAD 514
+++ E KF E +++ + + R + E + + + +E LR++ +
Sbjct: 1509 RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQERE 1568
Query: 515 SSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTK 574
+ +K ++EE E + K + + L E +E+ K +
Sbjct: 1569 EQQLSRQERDRKFRLEEQKVRRQE------QERKFMEDEQQLRRQEGQQQLRQERDRKFR 1622
Query: 575 KDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNI 634
+D+ + L++ E+ + ++D + L EE P+ + +
Sbjct: 1623 EDE-----QLLQEREEQQLHRQERDRKFL----EEEPQLRRQEREQQLRH---------- 1663
Query: 635 IDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMD-NLDNAQTSGIEE 693
D K E++++ Q ++ L + D +F + E + ++E
Sbjct: 1664 -DRDRKFREEEQLL----------QEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQE 1712
Query: 694 PSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVL 753
+ + + KF+ EEE E + RQ+ K+ + + +P+ + L
Sbjct: 1713 EQQLRRQELERKFR-----EEEQLRQETEQEQLRRQERYRKI---LEEEQLRPEREEQQL 1764
Query: 754 EPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGE---DEVEEE 810
+ + K +EE+ R + ++R Q++D+K E E E EE+
Sbjct: 1765 RRQERDRKFREEEQ--------------LRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810
Query: 811 STALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKS 870
Q+ D K ++ + + +++ + ++ + S +E E E+
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQE-LWQEEE 1869
Query: 871 SAASEEEEEKESEEAILADDDE 892
+E E K EE I E
Sbjct: 1870 QKRRQERERKLREEHIRRQQKE 1891
Score = 47.8 bits (112), Expect = 8e-05
Identities = 56/292 (19%), Positives = 105/292 (35%), Gaps = 19/292 (6%)
Query: 1064 STILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSD 1123
+T LDEE++ + + R++ + EEE + Q+ +
Sbjct: 92 ATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG 151
Query: 1124 ENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEEN 1183
E E +E D D R+ R+ RR + + + EE EE
Sbjct: 152 EEQSEKQERLEQRDRQRRD--EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 1184 SRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRR 1243
R E +E RR+ Q+++ ++ + +K R+ + + R + +
Sbjct: 210 LRRRE----------LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259
Query: 1244 LSSSE-------SEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPS 1296
L E EE + E EL +E + +++ R E ++EEE +
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 1297 RKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEE 1348
+R + +++E Q R Q E+E ++ R E +EE
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Score = 42.7 bits (99), Expect = 0.003
Identities = 53/285 (18%), Positives = 107/285 (37%), Gaps = 30/285 (10%)
Query: 1094 LDSDSNLDEEESE----DEFKISDGSQDEFVVSDENPDESEEDPPSN------DDSDTDF 1143
L + LDEE+ E + D Q+E E D E+ P + + +
Sbjct: 89 LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148
Query: 1144 CSRRLRRHPSRPMRQSRRLRRKTP----KKKYSDDDEEEESEENSRDSESDFSDDFSDDF 1199
+ + Q R RR ++++ + +E EE + + +++F D+
Sbjct: 149 AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE- 207
Query: 1200 VETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSE 1259
E RRR +R+ ++ + Q + + +E + KR + EE + +
Sbjct: 208 -EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 1260 DDELAKESKRSVRKRGRSTDEYSEADEEEEE-----EEGKPSRKRLHRIETDEEESCDNA 1314
+E + +RK R +EE+++ E+ ++ R E EE
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326
Query: 1315 HGDANQPARDSQPR---------VLPSEQESTKKPYRIESDEEED 1350
+ + R+ Q R L EQE ++ ++ ++EE+
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 92.4 bits (228), Expect = 3e-18
Identities = 248/1267 (19%), Positives = 486/1267 (38%), Gaps = 205/1267 (16%)
Query: 212 VLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVL 271
+LL QQ++S +++ S D+ KK + K E +KE ++ ++ ++ T V
Sbjct: 301 ILLNKDVQQESSEQKNKS-TDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVK 359
Query: 272 EETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRA 331
+E K+ KE E E +KLP EK + + + KE+ +V + ++
Sbjct: 360 DE---KQAKEKEVESLKLP----SEKNSNKAKTVEGTKEDFSLIDSDVDGL-TDITVSSV 411
Query: 332 DPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKL 391
D SS E+ +E +T S EE E + +D + K K + +
Sbjct: 412 HTSDL-SSFEEDTEEE--------------VVTSDSMEEGE-ITSDDEEKNKQNKTKTQT 455
Query: 392 SDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERV 451
SD + K V + K ++E + + ++L+ +++ E++
Sbjct: 456 SDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKL 515
Query: 452 APNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMK-----TGELEKET 506
K + +TK +TK + S ++ E + T+SL +K LEK+
Sbjct: 516 EEKRKQKAEKTKSSKTKGQGRS-----SVDLEESSTKSLEPKAARIKEVLKERKVLEKKV 570
Query: 507 APLRKDADSSISVLEIHSQKAQIEEPDPPEMETS-------LDSSE-----MAKDLSSKT 554
A +K S +V E +K Q EE ++TS + SS+ AK SK
Sbjct: 571 ALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKP 630
Query: 555 ALSSTESCTMKGEEKSPK------TKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPE 608
A +ES + E K+ ++ P I+E +++ ++ + +
Sbjct: 631 ARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEP 690
Query: 609 EVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVK-KVDLE 667
+ KSTL++EK + +ET +++ +++ S KE E + T + SVK K +
Sbjct: 691 QKQKSTLKNEKHLKKDDSETPHLKSLLK--KEVKSSKEKPEREKTPSEDKLSVKHKYKGD 748
Query: 668 TLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSE 727
+ + + T++ E+ + + ++QK + KL +++ T
Sbjct: 749 CMHKTGDETELHSS----------EKGLKVEENIQKQSQQTKLSSDDK---------TER 789
Query: 728 RQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAK 787
+ K + + + + KP S + EN +++ K+E + + +T ++ SR ++
Sbjct: 790 KSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKT--KAEHKSRRSSD 847
Query: 788 VAEIRDQKADKKRG---------EGEDEVEEESTALQKTDK-KEILKKSEKDTNSKV-SK 836
+D K+ G ED+ + +ST + K +E++ K ++ T S + K
Sbjct: 848 SKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEK 907
Query: 837 VKPKGKVRWTGSRTRGRW-KYSSNDESEGSGSEKSSAASEEE---EEKESEEAILAD-DD 891
+ K K S+T+G+ K + EG+ + ++ ++E EE +SE+ + +D
Sbjct: 908 LVLKSK-----SKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVED 962
Query: 892 EPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQL 951
+P ++ G+ P L S S + R L L EK +
Sbjct: 963 KPFEETGV--EPVLETASSSAHSTQKDSSHRAKL---------------PLAKEKYKSDK 1005
Query: 952 QDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKA----NL 1007
L++K + L + I+ ++ + S+D++ K+ DS KA +L
Sbjct: 1006 DSTSTRLERKLSDGHKSRSLKHSSKDIKK----KDENKSDDKDGKEVDSSHEKARGNSSL 1061
Query: 1008 LERRSTRTRKCISYR---FDEFDEAIDEAIEDDIKEADGGGVGRGK---DISTITGHRGK 1061
+E++ +R R C + R E + ++ + + G + R K D++ I
Sbjct: 1062 MEKKLSR-RLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPM 1120
Query: 1062 DIST------ILDEERKENKR-------------PQRAAAARRKKRRRLNDLDSDSNL-- 1100
+I + + + + ++ R Q+ +A +K R DS +
Sbjct: 1121 EIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPA 1180
Query: 1101 ------------DEEESEDEFKISDGSQDEFVVSDENPDESE--EDPPSNDDSDTDFCSR 1146
E+ ++ ++ + VS NP E E + + D++ R
Sbjct: 1181 YKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHR 1240
Query: 1147 RLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRR 1206
L PS R + L+ ++ + D E N D S S V R
Sbjct: 1241 MLLSAPSENDRVQKNLKNTAAEEHVAQGDATLEHSTN-----LDSSPSLSSVTVVPLRE- 1294
Query: 1207 SRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNS---EDDEL 1263
+Y D ++++ G S+S ++ S L S + E+
Sbjct: 1295 ---------SYDPDVIPLFDKRTVLEGS--------TASTSPADHSALPNQSLTVRESEV 1337
Query: 1264 AKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPAR 1323
K S G + D ++A + H E + D G P
Sbjct: 1338 LKTSDSKEGGEGFTVDTPAKAS----------ITSKRHIPEAHQATLLDGKQGKVIMPLG 1387
Query: 1324 DSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENL 1383
V+ + TK+ ++ ++E+ N P + NG+ G A++++
Sbjct: 1388 SKLTGVIVENENITKEGGLVDMAKKENDLN----AEPNLKQTIKATVENGKKDGIAVDHV 1443
Query: 1384 IGKPTEK 1390
+G TEK
Sbjct: 1444 VGLNTEK 1450
Score = 85.1 bits (209), Expect = 4e-16
Identities = 267/1286 (20%), Positives = 493/1286 (38%), Gaps = 228/1286 (17%)
Query: 218 SQQDNSSRESPSLEDEETKKE--EETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETT 275
+Q+ +++R S + +T + ++ P Q S + + M + +STA+ E
Sbjct: 212 NQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGL 271
Query: 276 VKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKD 335
K +E + P P E K KE ++ N K+ + + +
Sbjct: 272 ETAPKSEEFS----------DLPCPVEEIKNYTKEHNNLILLN--------KDVQQESSE 313
Query: 336 TKSSMEKPVAQEPERIEFGGNIKSSHEITEKS------TEETEKLKNDQQAK-------- 381
K+ ++P+ E G K E TEK +E+T+K+K+++QAK
Sbjct: 314 QKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLK 373
Query: 382 IPLKKREIKLS------DDF---DSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTIT 432
+P +K K +DF DS V G +T + D EE+T + + T
Sbjct: 374 LPSEKNSNKAKTVEGTKEDFSLIDSDVDG--LTDITVSSVHTSDLSSFEEDTEEEVVT-- 429
Query: 433 ALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNS 492
+ GE++ + N + + +T+ S K +++ L S
Sbjct: 430 -----SDSMEEGEITSDDEEKNKQNKT------KTQTSDSSEGKTKSVRHAYVHKPYLYS 478
Query: 493 VITSMKTGEL--EKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDL 550
S EL E+ + K+ + + +I+ +K + + E K
Sbjct: 479 KYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAE-----------KTK 527
Query: 551 SSKTALSSTESCTMKGEEKSPKTKKDKRPPILECL-EKLEKSKKTFLDKDAQRLSPIPEE 609
SSKT S + EE S K+ + K I E L E+ KK L K ++ S EE
Sbjct: 528 SSKTKGQGRSSVDL--EESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEE 585
Query: 610 VPKSTLESEKPGSPEAAETSPPSNIIDHCEK--LASEKEVVECQSTSTVGGQSVKKVD-L 666
K + E+ S E +TS +HCEK ++S KE+ + S + + + L
Sbjct: 586 NSKKKQQYEED-SKETLKTS------EHCEKEKISSSKELKHVHAKSEPSKPARRLSESL 638
Query: 667 ETLKEDSEFTKVEMDNLDNAQT----SGIEEPSETKGSMQKSKFKYKLVPEEETTASENT 722
+ E+ +K+E ++ T G++E ++T+ ++ E +
Sbjct: 639 HVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQV---------------ERS 683
Query: 723 EI-TSERQKEGIKLTIRISSRKKKPDSPP----KVLEPENKQEKTEKEEEKTNVGRTLRR 777
EI T E QK+ K T++ KK DS +L+ E K K + E EKT L
Sbjct: 684 EICTEEPQKQ--KSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSV 741
Query: 778 SPRISRPTA-KVAEIRDQKADKKRGEGEDEVEEES--TALQKTDKKEILKKSEKDTNSKV 834
+ K + + + +K + E+ ++++S T L DK E +KS+ K+
Sbjct: 742 KHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTE--RKSKHRNERKL 799
Query: 835 SKVKPKGK-VRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEP 893
S + GK V +T + +N + +EK+ A E + + S ++ + D
Sbjct: 800 SVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKA---EHKSRRSSDSKIQKDSLG 856
Query: 894 CKKCGLPNHPELILLC-DSCD--SGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQ 950
K+ G+ D CD S + L+P ++ HK ++ +
Sbjct: 857 SKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVV------------HKE--KRRTKS 902
Query: 951 LQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLER 1010
L + + LK K + + ++ ++V + P +++ ++ DS+K + + +E
Sbjct: 903 LLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVED 962
Query: 1011 RSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEE 1070
+ F+E +E ++ A KD S HR K + E+
Sbjct: 963 KP-------------FEET---GVEPVLETASSSAHSTQKDSS----HRAK--LPLAKEK 1000
Query: 1071 RKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESE 1130
K +K D + E K+SDG + + + D +
Sbjct: 1001 YKSDK-------------------------DSTSTRLERKLSDGHKSR-SLKHSSKDIKK 1034
Query: 1131 EDPPSNDDSD---TDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDS 1187
+D +DD D D + R + S L K ++ ++ S+E ++
Sbjct: 1035 KDENKSDDKDGKEVDSSHEKARGNSS--------LMEKKLSRRLCENRRGSLSQEMAKGE 1086
Query: 1188 ESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSS 1247
E ++ S + +R + I +E E D S+ + E+ + R ++S
Sbjct: 1087 EKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEID-SEPGVENVFEVSKTQDNRNNNS 1145
Query: 1248 ESE---ESYLSKNS---EDDEL---AKESKRS--VRKRGRSTDEYSEADEEEEEEEGKPS 1296
+ + E+ K S + DEL +SK + K GR T S + E+ +
Sbjct: 1146 QQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNS--NSEKHADHRSTL 1203
Query: 1297 RKRLH------RIETDEEESCDNAHGDANQPARDSQPRVL--PSEQESTKKPYRIESDEE 1348
K++H ++ E+E + N + +L PSE + +K + + E
Sbjct: 1204 TKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAE- 1262
Query: 1349 EDFENVGKVGSPLDYS--LVDLPSTNGQS--PGKAIENLIGKPTEKSQTPKDNSTASASL 1404
E+V + + L++S L PS + + P + + P +T + STAS S
Sbjct: 1263 ---EHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSP 1319
Query: 1405 ASNGTSGGQEAGAPEEEEDELLRVTD 1430
A + Q E E+L+ +D
Sbjct: 1320 ADHSALPNQSLTV---RESEVLKTSD 1342
Score = 66.2 bits (160), Expect = 2e-10
Identities = 179/940 (19%), Positives = 348/940 (37%), Gaps = 144/940 (15%)
Query: 571 PKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSP 630
P+ +K + K E S T D + S I + VP PG P A +
Sbjct: 149 PQVEKAVHEFLATLNHKEEGSGNTAPDDEKPDTSLITQGVPT-------PG-PSANVAND 200
Query: 631 PSNIIDHCEKLASEKEVVECQ---STSTVGGQSVKKVDLETLKE---DSEFTKVEMDNLD 684
+I++ L E S + ++ KK+ + + D E T +M + +
Sbjct: 201 AMSILETITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKE 260
Query: 685 NAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASE-------NTEITSERQKEGIKLTI 737
+ E ET ++ V E + E N ++ E ++ K T
Sbjct: 261 KSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKST- 319
Query: 738 RISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKAD 797
+KKPDS K + K+EKTEK+ + S+ + +++D+K
Sbjct: 320 --DKGEKKPDSNEKGERKKEKKEKTEKKFDH-------------SKKSEDTQKVKDEKQA 364
Query: 798 KKRGEGEDEVEEESTALQK-TDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKY 856
K E EVE +K ++K + ++ +++D + S V + + T +
Sbjct: 365 K-----EKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSF 419
Query: 857 SSNDESE---GSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCD 913
+ E E E+ S++EE+ + + D K H +
Sbjct: 420 EEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYV-------- 471
Query: 914 SGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEK----LEEQLQDLDVALKKKERAERRK- 968
H L D E + + EK L Q+ + K+K++AE+ K
Sbjct: 472 ---HKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKS 528
Query: 969 -------ERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISY 1021
V + S + P+ E +E+K KK + ++ +R + S
Sbjct: 529 SKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSK 588
Query: 1022 RFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTI--------TGHRGKDISTILDEERKE 1073
+ +++E E ++ + + + K++ + R + ++DE + E
Sbjct: 589 KKQQYEEDSKETLKTS-EHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNE 647
Query: 1074 NKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESE--- 1130
+K R KRR + + +E ++ D + + S+ + E P + +
Sbjct: 648 SK------LEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSE----ICTEEPQKQKSTL 697
Query: 1131 --EDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTP-------KKKY--------SD 1173
E DDS+T L++ + R KTP K KY D
Sbjct: 698 KNEKHLKKDDSETPHLKSLLKKEVKSSKEKPE--REKTPSEDKLSVKHKYKGDCMHKTGD 755
Query: 1174 DDEEEESE-----ENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQK 1228
+ E SE E + +S + SDD E R+S+ +R+++ S+
Sbjct: 756 ETELHSSEKGLKVEENIQKQSQQTKLSSDDKTE---RKSKHRNERKLSVLGKDGKPVSEY 812
Query: 1229 SLRRGKEIRRVH---KRRLSSSESEESYLSKNSEDDELAKESKRSVRKRG----RSTDEY 1281
++ + +R+ + +RRLS+ +++ + S+ S D ++ K+S S ++ G R ++ Y
Sbjct: 813 IIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGS-KQHGITLQRRSESY 871
Query: 1282 SE---------ADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPAR--DSQPRVL 1330
SE D + EE KR + +E+ + + + +++ +
Sbjct: 872 SEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEG 931
Query: 1331 PSEQESTKKPYRIESDEEEDFENVGK---VGSPLDYS----LVDLPSTNGQSPGKAIENL 1383
++Q +T KP + ++ EE D E K P + + +++ S++ S K +
Sbjct: 932 ATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHR 991
Query: 1384 IGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEED 1423
P K + D + S L + G + +D
Sbjct: 992 AKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKD 1031
Score = 49.3 bits (116), Expect = 3e-05
Identities = 48/259 (18%), Positives = 102/259 (39%), Gaps = 33/259 (12%)
Query: 1062 DISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVV 1121
D +LD + +R K DL+ E + ++ + +DE+
Sbjct: 2786 DNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVME-EKDEYSS 2844
Query: 1122 SD---ENPDESEEDPPSNDDSDTDFCSRRLRRHPSR-PMRQSRRLR-------------R 1164
S+ E P+++++D + + D +R R P + P+ + +++ +
Sbjct: 2845 SETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQ 2904
Query: 1165 KTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESD 1224
K +E ++E + E S+D ++ + T RR R KR + +D+ES
Sbjct: 2905 SPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESS 2964
Query: 1225 GSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEA 1284
++ KR+ S S+ E + S+++E E + G +T + +
Sbjct: 2965 EPER------------KRQKSVSDPVEDKKEQESDEEE---EEEEEDEPSGATTRSTTRS 3009
Query: 1285 DEEEEEEEGKPSRKRLHRI 1303
+ + + + PS KR +
Sbjct: 3010 EAQRSKTQLSPSIKRKREV 3028
Score = 48.1 bits (113), Expect = 6e-05
Identities = 89/403 (22%), Positives = 153/403 (37%), Gaps = 52/403 (12%)
Query: 468 KEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKA 527
K E+Y PS++ G S+ +G E + PL + L + +
Sbjct: 2671 KMEAYVPSEEEK---NGEILAPPESLCGGKPSGIAELQREPLLVNES-----LNVENSGF 2722
Query: 528 QIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEK 587
+ E E + S KD + + S E+ + EE+ K KR E
Sbjct: 2723 RTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLSSED 2782
Query: 588 LEKSKKTFLD---KDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASE 644
LD + AQR PE P T E E +TS +N ++ E
Sbjct: 2783 EPDDNPDVLDSRIETAQR--QCPETEPHDTKEENSRDLEELPKTSSETN--STTSRVMEE 2838
Query: 645 KEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQK- 703
K+ S+S G+ ++ D +T+K E + + + P ET M+
Sbjct: 2839 KDEY---SSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPR---KYPVETTLKMKDD 2892
Query: 704 SKFKYKLVPEEETTASENTEI--TSERQKEGIKLTIR-----------ISSRKKKPDSPP 750
SK +V E++ +S ++ T E KE L R ++S +++ P
Sbjct: 2893 SKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPK 2952
Query: 751 KVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEE 810
+ L + E +E E +R +S P V + ++Q++D+ E+E EEE
Sbjct: 2953 RSLTVSDDAESSEPER---------KRQKSVSDP---VEDKKEQESDE-----EEEEEEE 2995
Query: 811 STALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGR 853
T + ++++ +K K +V G+RTRG+
Sbjct: 2996 DEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQ 3038
Score = 43.1 bits (100), Expect = 0.002
Identities = 131/727 (18%), Positives = 275/727 (37%), Gaps = 102/727 (14%)
Query: 176 YIEEQDDQDGSSWKCIVRNRN----ELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLE 231
Y E++ D D ++ ++ E T +LL+ ++ VL S Q + +
Sbjct: 871 YSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKL--VLKSKSKTQGKQVKVVETEL 928
Query: 232 DEETKKEEETPKQEEQKESEKMKSEEQ------PMDLENRSTANVLE--ETTVKKEKEDE 283
E K+ TPK +++K +E+ SE+Q E VLE ++ ++D
Sbjct: 929 QEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDS 988
Query: 284 KELVKLPVIVKLEKPLPENEEKKIIKEESDSFK-ENVKPIKVEVKECRADPKDTKSSMEK 342
KLP+ + K ++ ++ ++ SD K ++K ++K+ + D K E
Sbjct: 989 SHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEV 1048
Query: 343 PVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGP 402
+ E R G + +++ + E + + AK K LS S ++ P
Sbjct: 1049 DSSHEKAR---GNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSSLQRP 1105
Query: 403 LCK---SVTPTKEFLKDEIKQEEETCKRIS-TITALGHEGKQLVNGEVSDERVAPNFKTE 458
++ P +E ++ + + E +S T + +Q ++ E ++ + + +
Sbjct: 1106 KKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKD 1165
Query: 459 PIETKFYETK--EESYSPSKDRNIITEGNGTES----------LNSVITSMKTGELE--- 503
+ T ++K +Y P + + + + S ++ M GE E
Sbjct: 1166 ELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIH 1225
Query: 504 KETAPLRKDADSSISVL-----EIHSQKAQIEEPDPPEMETSLDSS-EMAKDLSSKTALS 557
+ T + D+++ +L E + ++ E D++ E + +L S +LS
Sbjct: 1226 RGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQGDATLEHSTNLDSSPSLS 1285
Query: 558 STESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLS----PIPEEVPKS 613
S ++ E P P+ + LE S + D L + E
Sbjct: 1286 SVTVVPLR-ESYDPDV-----IPLFDKRTVLEGSTASTSPADHSALPNQSLTVRESEVLK 1339
Query: 614 TLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDS 673
T +S++ G +T ++I S++ + E + + G+ K + + S
Sbjct: 1340 TSDSKEGGEGFTVDTPAKASI-------TSKRHIPEAHQATLLDGKQGKVI----MPLGS 1388
Query: 674 EFTKVEMDNLDNAQTSGIEEPSETKGSM-------QKSKFKYKLVPEEETTASENTEITS 726
+ T V ++N + + G+ + ++ + + Q K + ++ + +
Sbjct: 1389 KLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVENGKKDGIAVDHVVGLNT 1448
Query: 727 ERQKEGIKLTIRISSRKKKPDSPPKVLEPE-NKQEKTEKEEEKTNVGRTLRRSPRISRPT 785
E+ E +KL K SP KV + + + + E E T+ G +
Sbjct: 1449 EKYAETVKL--------KHKRSPGKVKDISIDVERRNENSEVDTSAG------------S 1488
Query: 786 AKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSE-KDTNSKVSKVKPKGKVR 844
+ Q+ + E+ +T ++ +K + +E KD + +S VK G
Sbjct: 1489 GSAPSVLHQR--------NGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVK-AGPAT 1539
Query: 845 WTGSRTR 851
T S TR
Sbjct: 1540 TTSSETR 1546
Score = 40.8 bits (94), Expect = 0.010
Identities = 37/181 (20%), Positives = 75/181 (41%), Gaps = 14/181 (7%)
Query: 214 LKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDL---ENRSTANV 270
L +S + NS+ E +E E T ++ EQ + + +KS+E+ + R
Sbjct: 2821 LPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRK 2880
Query: 271 LEETTVKKEKEDEKELVKLPVI--------VKLEKPLPENEEKKIIKEESDSFKENVKPI 322
T K K+D K + + +K+ + N+E ++E S S + + I
Sbjct: 2881 YPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKI 2940
Query: 323 KVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKI 382
V+ PK + + + + EPER S + +K +E+++ + +++
Sbjct: 2941 VTSVRRRGRKPKRSLTVSDDAESSEPERKR---QKSVSDPVEDKKEQESDEEEEEEEEDE 2997
Query: 383 P 383
P
Sbjct: 2998 P 2998
Score = 37.0 bits (84), Expect = 0.14
Identities = 37/178 (20%), Positives = 71/178 (39%), Gaps = 18/178 (10%)
Query: 1068 DEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKIS-----DGSQDEFVVS 1122
D+ K + Q R++ R R +++ + ++ D ++ S+ + + +
Sbjct: 2857 DDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQT 2916
Query: 1123 DENPDES---EEDPPSNDDSDTDFCS--RRLRRHPSRPMRQS--------RRLRRKTPKK 1169
DE+ E+ +E SNDD + + RR R P R + S R R+K+
Sbjct: 2917 DESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSD 2976
Query: 1170 KYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQ 1227
D E+E EE + E + S + + +RS+ I K + G++
Sbjct: 2977 PVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGAR 3034
Score = 35.0 bits (79), Expect = 0.52
Identities = 204/1077 (18%), Positives = 380/1077 (35%), Gaps = 217/1077 (20%)
Query: 168 DQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRES 227
D+D + EE D ++ + N+N LA K Q +++ S+ D + + S
Sbjct: 2031 DEDIITSVENEECDGLMATTASGDITNQNSLAGG----KNQGKVLIISTSTTNDYTPQVS 2086
Query: 228 PSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELV 287
++ D E + + EE E ++ +EE + + + + + T + E++DE ++
Sbjct: 2087 -AITDVEGGLSDAL-RTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTASRSEEKDECAMI 2144
Query: 288 KLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQE 347
+ + E P+ K E+++P+ V+E P ++
Sbjct: 2145 STSIGEEFELPISSATTIKC--------AESLQPVAAAVEERATGPVLISTA-------- 2188
Query: 348 PERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSV 407
+F G + S+ E T K + D+ A I ++++ ++ V G + +S
Sbjct: 2189 ----DFEGPMPSAPPEAESPLASTSKEEKDECALI-----STSIAEECEASVSGVVVES- 2238
Query: 408 TPTKEFLKDEIKQEEETCKRISTITALGHEG--KQLVNGEVSDERVAPNFK---TEPIET 462
+ + +E++ IST + EG V E D V P + T I T
Sbjct: 2239 ---ENERAGTVMEEKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMGDTAMIST 2295
Query: 463 KFYETKEESY--SPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVL 520
E E + +D + +T + ++ I S T E +A + + ++ ++
Sbjct: 2296 STSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTA- 2354
Query: 521 EIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESC-----TMKGEEKSP---- 571
D PE L ++E++K +L + +C G+E P
Sbjct: 2355 ------------DNPEGNGDLSATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAV 2402
Query: 572 ------------KTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPK-STLE-- 616
K + P C EK EK K+ + P K STL
Sbjct: 2403 STEEGHNGPSVHKPSAGQGHPSAVCAEKEEKH-----GKECPEIGPFAGRGQKESTLHLI 2457
Query: 617 --SEKP---GSPEAAETSPPSNIIDHCEKLA-SEKEVVECQSTSTVGGQSVKKVDLETLK 670
EK S + + SP + + S +E + S + ++ +T K
Sbjct: 2458 NAEEKNVLLNSLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAK 2517
Query: 671 EDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQK 730
+ S V + L T I+ ++ +Q + ++ +P E+ + +N + ++ +
Sbjct: 2518 DPS----VSIRYLAAVNTGAIK--ADDMPPVQGTVAEHSFLPAEQQGSEDNLKTSTTKCI 2571
Query: 731 EGIKLTIRISSRKKKPDS-PPKVLEPENKQEKTEKEE-----------EKTNVGRTLRRS 778
G + I S P + +L P+ +Q+ T K + EKT + R+S
Sbjct: 2572 TGQESKIAPSHTMIPPATYSVALLAPKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKS 2631
Query: 779 PRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKV- 837
+ D E V L+ K E SE++ N ++
Sbjct: 2632 FPEEGDIMVTVSSEENVCDIGNEESPLNV-LGGLKLKANLKMEAYVPSEEEKNGEILAPP 2690
Query: 838 ------KPKG---------------KVRWTGSRTRGRWKYSSNDESEGSGSEKSSAAS-- 874
KP G V +G RT S ++ E S K +A +
Sbjct: 2691 ESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAIS 2750
Query: 875 -----------EEEE----EKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTA 919
EEEE +++ ++ L+ +DEP ++P+++ DS TA
Sbjct: 2751 GHSVEADPKEVEEEERHMPKRKRKQHYLSSEDEP------DDNPDVL------DSRIETA 2798
Query: 920 CLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERR--KERLVYVGIS 977
+ CP + E+ L++L + R +E+ Y
Sbjct: 2799 ------------QRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSE 2846
Query: 978 IENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDD 1037
P Q D + K ++ + +++R+ R RK +E
Sbjct: 2847 TTGEKPEQNDD------DTIKSQEEDQPIIIKRKRGRPRK--------------YPVETT 2886
Query: 1038 IKEADGGGVGRGKDISTITGHRGKDISTI----LDEERKENKRPQRAAAA---------- 1083
+K D D +T + S + DE KE Q + +
Sbjct: 2887 LKMKDDSKT----DTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVT 2942
Query: 1084 ----RRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQD-EFVVSDENPDESEEDPPS 1135
R +K +R + D+ E E + + +SD +D + SDE +E EED PS
Sbjct: 2943 SVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPS 2999
Score = 30.8 bits (68), Expect = 9.8
Identities = 26/85 (30%), Positives = 35/85 (41%), Gaps = 21/85 (24%)
Query: 1283 EAD--EEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKK- 1339
EAD E EEEE P RKR + E+E DN P VL S E+ ++
Sbjct: 2755 EADPKEVEEEERHMPKRKRKQHYLSSEDEPDDN-------------PDVLDSRIETAQRQ 2801
Query: 1340 -----PYRIESDEEEDFENVGKVGS 1359
P+ + + D E + K S
Sbjct: 2802 CPETEPHDTKEENSRDLEELPKTSS 2826
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 87.4 bits (215), Expect = 9e-17
Identities = 149/688 (21%), Positives = 262/688 (38%), Gaps = 109/688 (15%)
Query: 220 QDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKE 279
Q + + + P+ ++TK ++ +E K + K + T V + V+K
Sbjct: 518 QKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKP 577
Query: 280 KEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSS 339
+ E K V+VK +KP+ + E K + E+ KE P+K EV E +A K++
Sbjct: 578 PKVES---KEKVMVKKDKPI-KTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAA 633
Query: 340 MEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPV 399
EK V +E + +K + EK + E K + K P+KK E ++ V
Sbjct: 634 KEKTVKKETK-------VKPEDKKEEKEKPKKEVAKKED--KTPIKKEEKPKKEEVKKEV 684
Query: 400 KGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEP 459
K KE K+E K+ ++ K+ + + E K+ EV E P
Sbjct: 685 K----------KEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPK----- 729
Query: 460 IETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISV 519
E K+ K ++E +L + + + A + I V
Sbjct: 730 -----KEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKV 784
Query: 520 LEIHSQKAQIEEPDPPEMETS--------LDSSEMAKDLSSKTAL-SSTESCTMKGEEKS 570
++ + A+ T+ + + AK+L ++ +L SS E T EE
Sbjct: 785 IKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELK 844
Query: 571 PK---TKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAE 627
+ KD +P LE +E EK K+T E V ++ E+ + AE
Sbjct: 845 AEEVDVTKDIKPQ-LELIEDEEKLKET-------------EPVEAYVIQKEREVTKGPAE 890
Query: 628 TSPPSNIID-----HCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDN 682
SP I CE+ E E VE Q + + E E ++
Sbjct: 891 -SPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYE------ 943
Query: 683 LDNAQTSGIEEPSET-KGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISS 741
+ A+T EEP E + + S K+ +EE+ +E E+++ ++
Sbjct: 944 -EKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRE-----SVASGD 997
Query: 742 RKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRG 801
+ + D + + E +Q + E +EE K + R+++ + ++
Sbjct: 998 DRAEEDMDEAIEKGEAEQSEEEADEED------------------KAEDAREEEYEPEKM 1039
Query: 802 EGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSS-ND 860
E ED V + DK +E+ + K G+++ GR SS +D
Sbjct: 1040 EAEDYV------MAVVDKAAEAGGAEEQYGFLTTPTKQ------LGAQSPGREPASSIHD 1087
Query: 861 ESEGSGSEKSSAASEEEEEKESEEAILA 888
E+ GSE + AS+EE ++ E A
Sbjct: 1088 ETLPGGSESEATASDEENREDQPEEFTA 1115
Score = 84.0 bits (206), Expect = 1e-15
Identities = 146/662 (22%), Positives = 272/662 (41%), Gaps = 64/662 (9%)
Query: 214 LKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEK--MKSEEQPMDLENRSTANVL 271
+K + ++ + ++ ++ E+ K+E+E PK+E K+ +K +K EE+P E + V
Sbjct: 628 VKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKK--EVK 685
Query: 272 EETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRA 331
+E +++KE +KE VK E P P+ +K++ KEE K+ K K E+K+
Sbjct: 686 KEIKKEEKKEPKKE-------VKKETP-PKEVKKEVKKEEKKEVKKEEKEPKKEIKKL-- 735
Query: 332 DPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKL 391
PKD K S P+++ + + E +K + K K ++ KI + K+E K
Sbjct: 736 -PKDAKKS-STPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPK--EKGKIKVIKKEGKA 791
Query: 392 SDDFDSPV-KGPLCKSVTPTKEFLK-DEIKQEEETCKRISTITALGHEGKQLVNGEVS-D 448
++ + V G +V K+ E +S+ L + ++L EV
Sbjct: 792 AEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVT 851
Query: 449 ERVAPNFKTEPIETKFYETKE-ESYSPSKDRNIITEGNGTESLNSVITSMKTGELE---K 504
+ + P + E K ET+ E+Y K+R +T+G + T+ GE E +
Sbjct: 852 KDIKPQLELIEDEEKLKETEPVEAYVIQKERE-VTKGPAESPDEGITTTEGEGECEQTPE 910
Query: 505 ETAPLRKDADSSISVLEIHSQ--KAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESC 562
E P+ K I E + E D E + ++ E +D +S+++
Sbjct: 911 ELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHS 970
Query: 563 TMKGEEKSPKTK----KDKRPPILECLEKLEKSKKTFLDK-DAQRLSPIPEEVPKSTLES 617
+ EE + ++KR + ++ E+ ++K +A++ +E K+
Sbjct: 971 PTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAR 1030
Query: 618 EKPGSPEAAETSP-PSNIIDHCEKLASEKEVVECQSTST--VGGQS-----VKKVDLETL 669
E+ PE E ++D + +E +T T +G QS + ETL
Sbjct: 1031 EEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETL 1090
Query: 670 K--EDSEFTKVEMDNLDN-----AQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENT 722
+SE T + +N ++ TSG + S + S + + P + + N
Sbjct: 1091 PGGSESEATASDEENREDQPEEFTATSGYTQ-STIEISSEPTPMDEMSTPRDVMSDETNN 1149
Query: 723 EITSERQKEGIKLTIRISSRKKKPDSPPKVLEPEN---KQEKTEKEEEKTNVGRTLRRSP 779
E T +E + +T SS + S P + P N + KT+ + K SP
Sbjct: 1150 EETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISP 1209
Query: 780 RISRPTAKVAE--IRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKV 837
S K + +RD + + ++++ +A+ SEK + SK +
Sbjct: 1210 PSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAV----------SSEKVSPSKSPSL 1259
Query: 838 KP 839
P
Sbjct: 1260 SP 1261
Score = 76.6 bits (187), Expect = 2e-13
Identities = 205/1043 (19%), Positives = 382/1043 (36%), Gaps = 151/1043 (14%)
Query: 412 EFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEES 471
+FLK + +++ ++ T + KQ + S E + P K P ++ E+KEE+
Sbjct: 509 DFLKQPLATQKDLTGQVPTPVVKQTKLKQRAD---SRESLKPAAKPLPSKSVRKESKEET 565
Query: 472 YSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEE 531
+T+ N E V + K + K+ P++ + S++ E+ S+ EE
Sbjct: 566 PE-------VTKVNHVEKPPKVESKEKV--MVKKDKPIKTETKPSVTEKEVPSK----EE 612
Query: 532 PDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKS 591
P P + E + + A D+ K A T K + + K +K+K P E +K +K+
Sbjct: 613 PSPVKAEVA---EKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEK--PKKEVAKKEDKT 667
Query: 592 --KKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVE 649
KK K + + +E+ K E +K E + +PP + +K ++E E
Sbjct: 668 PIKKEEKPKKEEVKKEVKKEIKK---EEKKEPKKEVKKETPPKEV----KKEVKKEEKKE 720
Query: 650 CQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEP---SETKGSMQKSKF 706
+ + +KK+ + K + ++ + + EE K K
Sbjct: 721 VKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKG 780
Query: 707 KYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEE 766
K K++ +E A E + G +++ P K LE E + E
Sbjct: 781 KIKVIKKEGKAA----EAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAE--RSLMSSPE 834
Query: 767 EKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEE----ESTALQKTDKKEI 822
+ T L+ +V +D K + E E++++E E+ +QK ++E+
Sbjct: 835 DLTKDFEELKAE--------EVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQK--EREV 884
Query: 823 LKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSND----ESEGSGSEKSSAASEEEE 878
K + + ++ + +G+ T K +D E EG+G E+SS + EE
Sbjct: 885 TKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEE 944
Query: 879 EKESEEAILADDDEPCKKC-----GLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEW 933
+ E+EEA ++D C P E ++ A +R + G+
Sbjct: 945 KAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEA------DAYIREKRESVASGD- 997
Query: 934 FCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQ 993
++ EE D+D A++K E + +E E D +ED
Sbjct: 998 -----------DRAEE---DMDEAIEKGEAEQSEEE--------------ADEEDKAEDA 1029
Query: 994 EEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDIS 1053
E++ + +K +A D +D+A E GG + ++
Sbjct: 1030 REEEYEPEKMEAE-----------------DYVMAVVDKAAE------AGGAEEQYGFLT 1066
Query: 1054 TITGHRG------KDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDE---EE 1104
T T G + S+I DE + A+ + + + + S + E
Sbjct: 1067 TPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEI 1126
Query: 1105 SEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRR 1164
S + + + S V+SDE +E E P + T + S + S+P
Sbjct: 1127 SSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKP-------AD 1179
Query: 1165 KTPKKKYSD---DDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDS 1221
TP +S+ D + + N+ S +D R + + + D
Sbjct: 1180 VTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDI 1239
Query: 1222 ESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEY 1281
+ S S + + S E++ L + S + L + + +
Sbjct: 1240 KDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSP 1299
Query: 1282 SEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSE--QESTKK 1339
E EE P K L + + + H Q D + LP+E ++
Sbjct: 1300 EVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAV 1359
Query: 1340 PYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNST 1399
P E + +D EN SP+D P + +SP IE ++ P S
Sbjct: 1360 PVSFEFSDAKD-ENERASVSPMDE-----PVPDSESP---IEKVL-SPLRSPPLIGSESA 1409
Query: 1400 ASASLASNGTSGGQEAGAPEEEE 1422
+ L+++ + G+ A +P EE+
Sbjct: 1410 YESFLSADDKASGRGAESPFEEK 1432
Score = 60.8 bits (146), Expect = 9e-09
Identities = 168/827 (20%), Positives = 295/827 (35%), Gaps = 147/827 (17%)
Query: 581 ILECLEKLEKSK--KTFLDKDAQRLSPIPEEVPKSTLESEKPGSPE----AAETSPPSNI 634
ILE LEKL+ K L +P V K T ++ S E AA+ P ++
Sbjct: 498 ILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSV 557
Query: 635 IDHCEKLASEKEVVECQSTSTVGGQ-SVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEE 693
+ S++E E + V V+ + +K+D ++ + EE
Sbjct: 558 -----RKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEE 612
Query: 694 PSETKGSM-QKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKV 752
PS K + +K K +E T + T++ E +KE + KK + +
Sbjct: 613 PSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEE-------KEKPKKEVAKKED 665
Query: 753 LEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEEST 812
P K+EK +KEE K V + +++ ++K KK + E +E
Sbjct: 666 KTPIKKEEKPKKEEVKKEVKKEIKKE--------------EKKEPKKEVKKETPPKEVKK 711
Query: 813 ALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSA 872
++K +KKE+ KK EK+ ++ K+ K T E++ + K
Sbjct: 712 EVKKEEKKEV-KKEEKEPKKEIKKLPKDAKKSST-----------PLSEAKKPAALKPKV 759
Query: 873 ASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGE 932
+EE K+ A ++ K + + +G TA + I G
Sbjct: 760 PKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIG- 818
Query: 933 WFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSED 992
P + L +DL K+ E + E + + I PQ + ED
Sbjct: 819 ----PAKELEAERSLMSSPEDL-----TKDFEELKAEE-----VDVTKDIKPQ-LELIED 863
Query: 993 QEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDI 1052
EEK K+++ +A ++++ T+ E+ DE I E +G +++
Sbjct: 864 -EEKLKETEPVEAYVIQKEREVTKGPA--------ESPDEGI--TTTEGEGECEQTPEEL 912
Query: 1053 STITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKIS 1112
+ DI DE A ++ D + + +E E +E
Sbjct: 913 EPVEKQGVDDIEKFEDE------------GAGFEESSETGDYEEKAETEEAEEPEE---- 956
Query: 1113 DGSQDEFV-VSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKY 1171
DG + V S +P E EE + D+ +R K
Sbjct: 957 DGEEHVCVSASKHSPTEDEESAKAEADA---------------------YIREKRESVAS 995
Query: 1172 SDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLR 1231
DD EE+ +E E++ S++ +D+ E + +R E + + +
Sbjct: 996 GDDRAEEDMDEAIEKGEAEQSEEEADE--EDKAEDAR-------------EEEYEPEKME 1040
Query: 1232 RGKEIRRVHKRRLSSSESEESYLSKNSEDDEL-----AKESKRSVRKR---GRSTDEYSE 1283
+ V + + +EE Y + +L +E S+ G S E +
Sbjct: 1041 AEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATA 1100
Query: 1284 ADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRI 1343
+DEE E++ + ++ E S + D RD + E T+ P
Sbjct: 1101 SDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSD--ETNNEETESP--- 1155
Query: 1344 ESDEEEDFENVGKVGSPL---DYSL-VDLPSTNGQSPGKAIENLIGK 1386
++F N+ K S L +YS D+ NG S G + GK
Sbjct: 1156 ----SQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGK 1198
Score = 52.0 bits (123), Expect = 4e-06
Identities = 114/581 (19%), Positives = 220/581 (37%), Gaps = 68/581 (11%)
Query: 345 AQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPV-KGPL 403
A++ R+ F GN + + E EKLK+ K PL ++ L+ +PV K
Sbjct: 481 AEKIIRVLFPGNSTQYNIL-----EGLEKLKHLDFLKQPLATQK-DLTGQVPTPVVKQTK 534
Query: 404 CKSVTPTKEFLKDEIKQ------EEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKT 457
K ++E LK K +E+ + +T + H K +V + K
Sbjct: 535 LKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKP---PKVESKEKVMVKKD 591
Query: 458 EPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVIT--SMKTGELEKETAPLRKDADS 515
+PI+T+ + E PSK+ + E + + + K ++KET K D
Sbjct: 592 KPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKV--KPEDK 649
Query: 516 SISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKK 575
+ + A+ E+ P + E E+ K++ + K E+K PK +
Sbjct: 650 KEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIK---------KEEKKEPKKEV 700
Query: 576 DKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNII 635
K P E ++++K +K + K+ + +++PK +S P S E P+ +
Sbjct: 701 KKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLS----EAKKPAALK 756
Query: 636 DHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSG----- 690
K+ ++E V+ S G+ +K ++ +K++ + + + T+
Sbjct: 757 P---KVPKKEESVK--KDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAA 811
Query: 691 -----IEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKK 745
I E + L + E +E ++T + + + L + K K
Sbjct: 812 AGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQ---LELIEDEEKLK 868
Query: 746 PDSPPKVLEPENKQEKTEKEEEKTNVGRTL-------RRSPRISRPTAKVAEIRDQKADK 798
P + + ++E T+ E + G T ++P P K + D + +
Sbjct: 869 ETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQG-VDDIEKFE 927
Query: 799 KRGEGEDEVEEESTALQKTDKKEILKKSEKDTN------SKVSKVKPKGKVRWTGS---R 849
G G +E E +K + +E + E SK S + + + R
Sbjct: 928 DEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIR 987
Query: 850 TRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADD 890
+ S +D +E E E+ E+E++E A+D
Sbjct: 988 EKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAED 1028
Score = 46.2 bits (108), Expect = 2e-04
Identities = 157/696 (22%), Positives = 262/696 (37%), Gaps = 119/696 (17%)
Query: 215 KNSSQQDNSSRESPSLEDEETKKE--EETP--------KQEEQKESEKMKSEEQ------ 258
K + +E E +E KKE +ETP K+EE+KE +K + E +
Sbjct: 676 KKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKL 735
Query: 259 PMDLENRST-ANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKE 317
P D + ST + ++ K K +KE V KP E + K+IK+E + +
Sbjct: 736 PKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKP-KEKGKIKVIKKEGKAAEA 794
Query: 318 NVKPIKV-----------------EVKECRAD------PKDTKSSMEKPVAQEPERIEFG 354
+ KE A+ P+D E+ A+E ++
Sbjct: 795 VAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEE---VDVT 851
Query: 355 GNIKSSHEITEKSTEETEKLKNDQ--QAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKE 412
+IK E+ E+ EKLK + +A + K+RE+ KGP + +P +
Sbjct: 852 KDIKPQLEL----IEDEEKLKETEPVEAYVIQKEREV---------TKGP---AESPDEG 895
Query: 413 FLKDEIKQE-EETCKRISTITALGHEGKQLVNGEVS--DERVAPNFKTEPIETKFYETKE 469
E + E E+T + + + G + + E + +E E ET+ E E
Sbjct: 896 ITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPE 955
Query: 470 E-----------SYSPSKDRNII---TEGNGTESLNSVITSMKTGELEKETAPLRKDADS 515
E +SP++D + E SV + E + + A + +A+
Sbjct: 956 EDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQ 1015
Query: 516 SISVL--EIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKT 573
S E ++ A+ EE +P +ME D D +++ + + + K
Sbjct: 1016 SEEEADEEDKAEDAREEEYEPEKMEAE-DYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGA 1074
Query: 574 KKDKRPPIL----ECLEKLEKSKKTFLDKDAQRLSP----IPEEVPKSTLESEKPGSPEA 625
+ R P E L +S+ T D++ + P +ST+E +P
Sbjct: 1075 QSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTP-M 1133
Query: 626 AETSPPSNII------DHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVE 679
E S P +++ + E + E + +S + K D+ L SE +K +
Sbjct: 1134 DEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTD 1193
Query: 680 -MDNLD-NAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTI 737
D D NA S I PS SM++ KF + + SE T+ K+ I
Sbjct: 1194 ATDGKDYNASASTISPPS----SMEEDKFSRSAL--RDAYCSEVKASTTLDIKDSIS--- 1244
Query: 738 RISSRKKKPDSPPKVL-EPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKA 796
+SS K P P + P + EKT E N T ++S A+VA +
Sbjct: 1245 AVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLT-PNEIKVS-AEAEVAPVSP--- 1299
Query: 797 DKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNS 832
E EV EE A + E++ S+ T S
Sbjct: 1300 -----EVTQEVVEEHCASPEDKTLEVVSPSQSVTGS 1330
Score = 42.7 bits (99), Expect = 0.003
Identities = 130/663 (19%), Positives = 234/663 (35%), Gaps = 114/663 (17%)
Query: 179 EQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKE 238
E+ ++DG C+ +++ E KA+ D + RES + D+ + E
Sbjct: 952 EEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYI--------REKRESVASGDD--RAE 1001
Query: 239 EETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKP 298
E+ + E+ E+E+ E+ D E+++ E ++E E EK + V+ ++K
Sbjct: 1002 EDMDEAIEKGEAEQ---SEEEADEEDKA------EDAREEEYEPEKMEAEDYVMAVVDK- 1051
Query: 299 LPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIK 358
E+ +E + K+ A +S +P + + GG
Sbjct: 1052 ----------AAEAGGAEEQYGFLTTPTKQLGA-----QSPGREPASSIHDETLPGG--- 1093
Query: 359 SSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEI 418
S E T E E + A + I++S + P+ + TP ++ + DE
Sbjct: 1094 SESEATASDEENREDQPEEFTATSGYTQSTIEISSE-----PTPMDEMSTP-RDVMSDET 1147
Query: 419 KQEEETCKRISTITALGHEGKQLVNGEVSDERVAP------NFKTEPIETKFYETKEESY 472
EE + +E V P KT+ + K Y +
Sbjct: 1148 NNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTI 1207
Query: 473 SPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEP 532
SP + S + E++ T KD+ S++S ++ K+ P
Sbjct: 1208 SPPSSM------EEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSP 1261
Query: 533 DPP-----------EMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPI 581
PP + SL +E+ ++ A S E T + E+ + +DK +
Sbjct: 1262 SPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPE-VTQEVVEEHCASPEDKTLEV 1320
Query: 582 LECLEKLEKS---KKTFLDKDAQRLSPIPEE-------VPKSTLESEKPGSPEAAETSPP 631
+ + + S + ++ S +P E VP S S+ E A SP
Sbjct: 1321 VSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPM 1380
Query: 632 SNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGI 691
+ E EK + +S +G +S + L D D A G
Sbjct: 1381 DEPVPDSES-PIEKVLSPLRSPPLIGSESAYE---SFLSAD-----------DKASGRGA 1425
Query: 692 EEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPK 751
E P E K Q S P++ + SE T + + K+ K D P
Sbjct: 1426 ESPFEEKSGKQGS-------PDQVSPVSEMTSTSLYQDKQ----------EGKSTDFAP- 1467
Query: 752 VLEPENKQEKTEKEEEKTN---VGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVE 808
+ E +++KT+ E ++ + R+ +S V++ K D K E V
Sbjct: 1468 IKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVS 1527
Query: 809 EES 811
++S
Sbjct: 1528 DKS 1530
Score = 36.6 bits (83), Expect = 0.18
Identities = 86/440 (19%), Positives = 173/440 (39%), Gaps = 61/440 (13%)
Query: 169 QDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDN--SSRE 226
+D N R + D+ + + + + + L+ L++ P L+ + S ++ S+ +
Sbjct: 1369 KDENERASVSPMDEP-------VPDSESPIEKVLSPLRS---PPLIGSESAYESFLSADD 1418
Query: 227 SPSLEDEETKKEEETPKQEEQKE----SEKMKSEEQPMDLENRST--ANVLEETTVKKEK 280
S E+ EE++ KQ + SE + E +ST A + E+ +K+
Sbjct: 1419 KASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKT 1478
Query: 281 EDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSM 340
+D + + P + E+ L + +I + SFKE+ K + + E K
Sbjct: 1479 DDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTK---MSISEGTVSDKSATPVD 1535
Query: 341 EKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVK 400
E +E ++ ++ T E T +D + ++ + V
Sbjct: 1536 EGVAEDTYSHMEGVASVSTASVATSSFPEPTT---DDVSPSL-----HAEVGSPHSTEVD 1587
Query: 401 GPLCKSV--TPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGE-VSDERVAPNFKT 457
L SV TPT F + E+ +E C R +I+ K + V D R +
Sbjct: 1588 DSLSVSVVQTPTT-FQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS----EQ 1642
Query: 458 EPIETKF-YETKEESYS-----PSKDRNIITEG------NGTESLNSVITSMKTGELEKE 505
+ +F E+ E+S + S D + G NG ++ + M+ L +
Sbjct: 1643 SSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHK 1702
Query: 506 TAPLRK-------DADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMA-----KDLSSK 553
P+ + D ISV ++ + + P ++ + L ++ +D+S
Sbjct: 1703 IPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLY 1762
Query: 554 TALSSTESCTMKGEEKSPKT 573
+L+S + +++GE+ SPK+
Sbjct: 1763 ASLTSEKVQSLEGEKLSPKS 1782
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 82.4 bits (202), Expect = 3e-15
Identities = 230/1211 (18%), Positives = 448/1211 (36%), Gaps = 139/1211 (11%)
Query: 215 KNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEET 274
+ SS + + ++PS + T + E+ K K+ E ++TA V +E
Sbjct: 293 EESSTESSEEEDAPSFAPSSSVDGNNTDSEFEKGLKHKAKNPEP-----QKATAPVKDEY 347
Query: 275 TVKKEKE-------DEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKEN--VKPIKVE 325
++ E D+K L+K K N I K E S+ +N + P K
Sbjct: 348 EFDEDDEQDRVPPVDDKHLLKKDY----RKETKSNSFISIPKMEVKSYTKNNTIAPKKAS 403
Query: 326 VKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKND--QQAKIP 383
+ +D D + + E R+ I + E S + +K KN ++ K
Sbjct: 404 HR-ILSDTSDEEDASVTVGTGEKLRLS-AHTILPGSKTREPSNAKQQKEKNKVKKKRKKE 461
Query: 384 LKKREI---KLSDDF-DSPVKGPLCKSVTPTKEFLKDE--IKQEEETCKRISTITAL--- 434
K RE+ K SD F S + +S ++ L +K K S ++L
Sbjct: 462 TKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSAS 521
Query: 435 -----GHEGKQLVNGEVSDERV----APNFKT--EPIETKFYETKEESYSP-SKDRNIIT 482
G Q N +D+ N+KT P ++ + + + + + + +
Sbjct: 522 STSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESDYSS 581
Query: 483 EGNGTESLNSVITSM---KTGELEKETAPLRKDADSSISVLEI---------------HS 524
EG+ ESL V K L ++ +P A+ ++ L+ +
Sbjct: 582 EGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNK 641
Query: 525 QKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCT-------------MKGEEKSP 571
+K Q ++++ E +K S K L + T K EEK
Sbjct: 642 EKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLS 701
Query: 572 KTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPP 631
K K +++ E L K EKS K D + EE +S ++ E +
Sbjct: 702 KMKLEEK----EWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEK 757
Query: 632 SNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVE------------ 679
+ K S+ + + + + + K + KED E K E
Sbjct: 758 LRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEY 817
Query: 680 ------MDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGI 733
++N D + ++ + S F +K ++ ++ ++ S+ + I
Sbjct: 818 CNKNQFLENEDTKFSLSDDQRDRWFSDLSDSSFDFKGEDSWDSPVTDYRDMKSDSVAKLI 877
Query: 734 KLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRD 793
T++ S++++ DS + E + +E +++++ + + + + V
Sbjct: 878 LETVKEDSKERRRDS--RAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLS 935
Query: 794 QKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGR 853
+K DKKR E + + AL+ K +D +K + + +++ G + +
Sbjct: 936 EK-DKKRRESAEAGRDRKDALESC-------KERRDGRAKPEEAH-REELKECGCESGFK 986
Query: 854 WKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCD 913
K S D +G + + E+E+K+ D E +K + E D +
Sbjct: 987 DK-SDGDFGKGLEPWERHHPAREKEKKDGP------DKERKEKTKPERYKEKSSDKDKSE 1039
Query: 914 SGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVY 973
C + E +HK K +E+ LD +KKE+A +
Sbjct: 1040 KSILEKCQKDKEFDKCFKEKKDTKEKHKDTHGKDKERKASLDQGKEKKEKA--------F 1091
Query: 974 VGISIENIIPPQEPDFSEDQEEKK-KDSKKSKANLLERRSTRTR-KCISYRFDEFDEAID 1031
GI E DFSE +++KK K+ A++ S R C+ F + EA D
Sbjct: 1092 PGIISE--------DFSEKKDDKKGKEKSWYIADIFTDESEDDRDSCMGSGF-KMGEASD 1142
Query: 1032 EAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRL 1091
D ++E + G D + + + D+E ++ ++ + AA A R K+ ++
Sbjct: 1143 LPRTDGLQEKEEGREAYASDRHRKSSDK-QHPERQKDKEPRDRRKDRGAADAGRDKKEKV 1201
Query: 1092 NDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRH 1151
+ + D+E +E D + + +N + E ++ S+ +
Sbjct: 1202 FEKHKEKK-DKESTEKYKDRKDRASVDSTQDKKNKQKLPEKAEKKHAAEDKAKSKHKEKS 1260
Query: 1152 PSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQ 1211
++ + R +K + EEE E DS S+ SD F + R +
Sbjct: 1261 DKEHSKERKSSRSADAEKSLLEKLEEEALHEYREDSNDKISEVSSDSFTD-RGQEPGLTA 1319
Query: 1212 KRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSV 1271
++++ E D ++S ++++ + R SSS S++S+ + ++ ++ K+ K
Sbjct: 1320 FLEVSFTEPPGDDKPRESACLPEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGED 1379
Query: 1272 RKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLP 1331
K G S + + +++ E + + DE + + DS+ P
Sbjct: 1380 YKEGGSRKDSGQYEKDFLEADAYGVSYNMKADIEDELDKTIELFSTEKKDKNDSERE--P 1437
Query: 1332 SEQ-ESTKKPY 1341
S++ E KPY
Sbjct: 1438 SKKIEKELKPY 1448
Score = 73.9 bits (180), Expect = 1e-12
Identities = 232/1119 (20%), Positives = 420/1119 (37%), Gaps = 149/1119 (13%)
Query: 223 SSRESPSLEDEE-----TKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVK 277
S ++SP L E KE + K+ + K K K + Q S + L+ +
Sbjct: 605 SEKKSPFLSSAEGAVPKLDKEGKVVKKHKTKHKHKNKEKGQC------SISQELKLKSFT 658
Query: 278 KEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFK--ENVKPIKVEVKECRADP-- 333
E ED K+ K + LE L + K++K + D FK E + +K+E KE
Sbjct: 659 YEYEDSKQ--KSDKAILLENDLSTENKLKVLKHDRDHFKKEEKLSKMKLEEKEWLFKDEK 716
Query: 334 -----KDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKST------EETEKLKNDQQAKI 382
KDT + + +E +R +S E + K EE +K D+ +K+
Sbjct: 717 SLKRIKDTNKDISRSFREEKDRSNKAEKERSLKEKSPKEEKLRLYKEERKKKSKDRPSKL 776
Query: 383 PLKK--REIKLS--------DDFDSPVKGPLCKSVTPTKEFL-KDEIKQEEETCKRIS-- 429
K +E K+S +D + K + + + E+ K++ + E+T +S
Sbjct: 777 EKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYREDSAFDEYCNKNQFLENEDTKFSLSDD 836
Query: 430 ---------TITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNI 480
+ ++ +G+ + V+D R + K++ + ET +E SK+R
Sbjct: 837 QRDRWFSDLSDSSFDFKGEDSWDSPVTDYR---DMKSDSVAKLILETVKED---SKERRR 890
Query: 481 ITEGNGTESLNSVITSMKTGE-LEKETAPLRKDADSSISVLEIHSQKAQIEEPDPP---E 536
+ K + L+K + ++ + SV S+K + +
Sbjct: 891 DSRAREKRDYREPFFRKKDRDYLDKNSEKRKEQTEKHKSVPGYLSEKDKKRRESAEAGRD 950
Query: 537 METSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKR-PPILECLEK----LEKS 591
+ +L+S + +D +K + E G E K K D LE E+ EK
Sbjct: 951 RKDALESCKERRDGRAKPEEAHREELKECGCESGFKDKSDGDFGKGLEPWERHHPAREKE 1010
Query: 592 KKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQ 651
KK DK+ + + PE + + + +K E D C K EK+ + +
Sbjct: 1011 KKDGPDKERKEKTK-PERYKEKSSDKDK-SEKSILEKCQKDKEFDKCFK---EKKDTKEK 1065
Query: 652 STSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLV 711
T G +K L+ KE E + + D E + K +KS + +
Sbjct: 1066 HKDTHGKDKERKASLDQGKEKKEKAFPGIISED------FSEKKDDKKGKEKSWYIADIF 1119
Query: 712 PEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNV 771
+E ++ + + E L R ++K + ++ K +K +
Sbjct: 1120 TDESEDDRDSCMGSGFKMGEASDLP-RTDGLQEKEEG-----REAYASDRHRKSSDKQHP 1173
Query: 772 GRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTN 831
R + PR R A+ K +K + +++ ++EST K D+K+ + S T
Sbjct: 1174 ERQKDKEPRDRRKDRGAADAGRDKKEKVFEKHKEKKDKESTEKYK-DRKD--RASVDSTQ 1230
Query: 832 SKVSKVK-PKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEE---EKESEEAIL 887
K +K K P+ + + + + K+ + E S KSS +++ E+ EK EEA+
Sbjct: 1231 DKKNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSADAEKSLLEKLEEEALH 1290
Query: 888 ADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKL 947
++ K + D TA L P + P + L EKL
Sbjct: 1291 EYREDSNDKISEVSSDS---FTDRGQEPGLTAFLEVSFTEPPGDD---KPRESACLPEKL 1344
Query: 948 EEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEE--KKKDSKKSKA 1005
+E+ + + K+ +R + + ++ + ED +E +KDS + +
Sbjct: 1345 KEKERHRHSSSSSKKSHDRERAKKE----------KAEKKEKGEDYKEGGSRKDSGQYEK 1394
Query: 1006 NLLERRSTRTRKCISYRF-----DEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRG 1060
+ LE + +SY DE D+ I E + K+ + K I G
Sbjct: 1395 DFLEADAYG----VSYNMKADIEDELDKTI-ELFSTEKKDKNDSEREPSKKIEKELKPYG 1449
Query: 1061 KDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFV 1120
IL E++K K ++ R ++ R D +D L +DE +
Sbjct: 1450 SSAINILKEKKKREKHREK----WRDEKERHRDRHADGLLRHH------------RDELL 1493
Query: 1121 VSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEES 1180
+E P+ D D+ R+ + SR + RL K+K+ D E+E+
Sbjct: 1494 -----RHHRDEQKPATRDKDS---PPRVLKDKSRD--EGPRLGDAKLKEKFKDGAEKEKG 1543
Query: 1181 EENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVH 1240
+ + +D D + R R + + E SQK L + +R H
Sbjct: 1544 DPVKMSNGNDKVAPSKDPGKKDARPREKLLGDGDL-MMTSFERMLSQKDLEIEERHKR-H 1601
Query: 1241 KRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTD 1279
K R+ E L S D +L +++K + R + D
Sbjct: 1602 KERMKQMEK----LRHRSGDPKLKEKAKPADDGRKKGLD 1636
Score = 42.0 bits (97), Expect = 0.004
Identities = 91/476 (19%), Positives = 186/476 (39%), Gaps = 66/476 (13%)
Query: 940 HKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIP---PQEPDFSEDQEEK 996
H++L + +E+ + V +K R +S I+P +EP ++ Q+EK
Sbjct: 404 HRILSDTSDEEDASVTVGTGEKLR------------LSAHTILPGSKTREPSNAKQQKEK 451
Query: 997 KKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDI---- 1052
K KK K R ++ + E + E+ EDD G +G +
Sbjct: 452 NKVKKKRKKETKGREVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKD 511
Query: 1053 ----STITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLD-------SDSNLD 1101
S+++ + +++ + Q R + ++ SDS
Sbjct: 512 PSLFSSLSASSTSSHGSSAAQKQNPSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRT 571
Query: 1102 EEESEDEFKISDGSQDEFVVSDENPDE-------SEEDPPSNDDSD-----TDFCSRRLR 1149
SE ++ S+GS E + E SE+ P ++ D + ++
Sbjct: 572 RLTSESDYS-SEGSSVESLKPVRKRQEHRKRASLSEKKSPFLSSAEGAVPKLDKEGKVVK 630
Query: 1150 RHPSRPMRQSRRLRR---KTPKKKYSDDDEEEESEENSRDS---ESDFSDDFSDDFVETR 1203
+H ++ +++ + K S E E+S++ S + E+D S + ++
Sbjct: 631 KHKTKHKHKNKEKGQCSISQELKLKSFTYEYEDSKQKSDKAILLENDLSTENKLKVLKHD 690
Query: 1204 RRRSRRNQK-RQINYKEDSESDGSQKSLRRGKEIR-------RVHKRRLSSSESEESYLS 1255
R ++ +K ++ +E +KSL+R K+ R K R + +E E S
Sbjct: 691 RDHFKKEEKLSKMKLEEKEWLFKDEKSLKRIKDTNKDISRSFREEKDRSNKAEKERSLKE 750
Query: 1256 KNSEDDELA-------KESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEE 1308
K+ ++++L K+SK K + D + +E+E+ K +++L + + E
Sbjct: 751 KSPKEEKLRLYKEERKKKSKDRPSKLEKKNDLKEDKISKEKEKIFKEDKEKLKKEKVYRE 810
Query: 1309 ESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPL-DY 1363
+S + + + NQ + + S+ + + + SD DF+ SP+ DY
Sbjct: 811 DSAFDEYCNKNQFLENEDTKFSLSDDQRDRW-FSDLSDSSFDFKGEDSWDSPVTDY 865
Score = 37.4 bits (85), Expect = 0.11
Identities = 100/479 (20%), Positives = 172/479 (35%), Gaps = 67/479 (13%)
Query: 215 KNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEET 274
KN + + + + ED+ K +E +E KE + +S + +S LEE
Sbjct: 1233 KNKQKLPEKAEKKHAAEDKAKSKHKEKSDKEHSKERKSSRSAD-----AEKSLLEKLEEE 1287
Query: 275 TVKKEKEDEKELVK---------------LPVIVKL--------EKP-----LPEN-EEK 305
+ + +ED + + L +++ +KP LPE +EK
Sbjct: 1288 ALHEYREDSNDKISEVSSDSFTDRGQEPGLTAFLEVSFTEPPGDDKPRESACLPEKLKEK 1347
Query: 306 KIIKEESDSFK-----ENVKPIKVEVKECRADPKDTKSSMEKPVAQ----EPERIEFGGN 356
+ + S S K E K K E KE D K+ S + + E + N
Sbjct: 1348 ERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEADAYGVSYN 1407
Query: 357 IKSSHEITEKSTEE---TEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEF 413
+K+ E T E TEK + + P KK E +L S + +E
Sbjct: 1408 MKADIEDELDKTIELFSTEKKDKNDSEREPSKKIEKELKPYGSSAIN---ILKEKKKREK 1464
Query: 414 LKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEES-- 471
+++ + E+E + L H +L+ +++ A K P ++++E
Sbjct: 1465 HREKWRDEKERHRDRHADGLLRHHRDELLRHHRDEQKPATRDKDSPPRVLKDKSRDEGPR 1524
Query: 472 YSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEE 531
+K + +G E + V S ++ P +KDA +L
Sbjct: 1525 LGDAKLKEKFKDGAEKEKGDPVKMSNGNDKVAPSKDPGKKDARPREKLL----------- 1573
Query: 532 PDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKS 591
D M TS + KDL + + MK EK D P + E + +
Sbjct: 1574 GDGDLMMTSFERMLSQKDLEIEERHKRHKE-RMKQMEKLRHRSGD--PKLKEKAKPADDG 1630
Query: 592 KKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASE--KEVV 648
+K LD A++ + L+ P P A P++ D + LA KEV+
Sbjct: 1631 RKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGADSKDWLAGPHMKEVL 1689
Score = 35.8 bits (81), Expect = 0.31
Identities = 62/329 (18%), Positives = 133/329 (40%), Gaps = 58/329 (17%)
Query: 1119 FVVSDENPDES--EEDPPS--------NDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPK 1168
+ S+E+ ES EED PS +++D++F + L+ P Q K
Sbjct: 289 YTSSEESSTESSEEEDAPSFAPSSSVDGNNTDSEF-EKGLKHKAKNPEPQKATA---PVK 344
Query: 1169 KKYSDDDEEEESEENSRDSESDFSDDF-----SDDFVETRRRRSRRNQK------RQINY 1217
+Y D+++E+ D + D+ S+ F+ + + K ++ ++
Sbjct: 345 DEYEFDEDDEQDRVPPVDDKHLLKKDYRKETKSNSFISIPKMEVKSYTKNNTIAPKKASH 404
Query: 1218 K---EDSESDGSQKSLRRGKEIR-RVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRK 1273
+ + S+ + + ++ G+++R H S E S + E +++ K+ K+ +
Sbjct: 405 RILSDTSDEEDASVTVGTGEKLRLSAHTILPGSKTREPSNAKQQKEKNKVKKKRKKETKG 464
Query: 1274 R----GRSTDEYSEADEEEEEEE----------------GKPSRKRLHRIETDEEESCDN 1313
R G+ +D++ ++ E E E G P + + + S +
Sbjct: 465 REVRFGKRSDKFCSSESESESSESGEDDRDSLGSSGCLKGSPLVLKDPSLFSSLSASSTS 524
Query: 1314 AHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPS-TN 1372
+HG + ++ PS + K +R ++ + +V S D + L S ++
Sbjct: 525 SHGSSAAQKQN------PSHTDQHTKHWRTDNWKTISSPAWSEVSSLSDSTRTRLTSESD 578
Query: 1373 GQSPGKAIENLIGKPTEKSQTPKDNSTAS 1401
S G ++E+L KP K Q + ++ S
Sbjct: 579 YSSEGSSVESL--KPVRKRQEHRKRASLS 605
Score = 31.2 bits (69), Expect = 7.5
Identities = 28/117 (23%), Positives = 49/117 (41%), Gaps = 11/117 (9%)
Query: 211 PVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANV 270
P LK + +SS S D E K+E+ K+E+ ++ ++ S + E
Sbjct: 1341 PEKLKEKERHRHSSSSSKKSHDRERAKKEKAEKKEKGEDYKEGGSRKDSGQYEKDFLEAD 1400
Query: 271 LEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVK 327
+ + + E EL K + EK K+++DS +E K I+ E+K
Sbjct: 1401 AYGVSYNMKADIEDELDKTIELFSTEK-----------KDKNDSEREPSKKIEKELK 1446
>gi|48255931 hepatoma-derived growth factor-related protein 2 isoform
1 [Homo sapiens]
Length = 671
Score = 82.4 bits (202), Expect = 3e-15
Identities = 89/359 (24%), Positives = 142/359 (39%), Gaps = 50/359 (13%)
Query: 990 SEDQEEKKKDSKKSKANL-LERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGR 1048
+ D+ E DS KS N L+R++ + +S R + +D+A +E +
Sbjct: 136 ASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSE 195
Query: 1049 GKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDE 1108
+ S E++ + P+R RKK++ + DSDS D
Sbjct: 196 SEKTSD---------QDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKAD------- 239
Query: 1109 FKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPK 1168
SDG++ E V + S S+ DSD R P+ R R+ P+
Sbjct: 240 ---SDGAKPEPVAMARSASSSSSSS-SSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPE 295
Query: 1169 KKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQK 1228
+ S + +S+E R SE D+ +E RRRR + + R++ +E E K
Sbjct: 296 RPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEE-----K 350
Query: 1229 SLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEE 1288
RR + R +R S +E EDDE K+ R R RG + SE + E
Sbjct: 351 ERRRERADRGEAERGSGGSSGDEL-----REDDEPVKKRGRKGRGRGPPSSSDSEPEAEL 405
Query: 1289 EEEEGKPSRKRLHRIETDEEESCDNAHGDANQPAR---DSQPRVLPSEQESTKKPYRIE 1344
E E K ++K + +PAR + RV P E++ KP ++E
Sbjct: 406 EREAKKSAKK---------------PQSSSTEPARKPGQKEKRVRPEEKQQA-KPVKVE 448
Score = 52.0 bits (123), Expect = 4e-06
Identities = 81/384 (21%), Positives = 139/384 (36%), Gaps = 60/384 (15%)
Query: 522 IHSQKAQIEEPDPPEM----ETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDK 577
+ S ++ E +P + E D MA + TA S ++ S + +
Sbjct: 98 VSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKR 157
Query: 578 RPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDH 637
+ P L+ + ++++K D D +SP EE +S+ ESEK +
Sbjct: 158 KTPALK-MSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFT----------- 205
Query: 638 CEKLASEKEVVECQSTSTVGGQSVKKVDLET---LKEDSEFTKVEMDNLDNAQTSGIEEP 694
+K V +GG+ KK + K DS+ K E + + +S
Sbjct: 206 ----PEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASS----- 256
Query: 695 SETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLE 754
S + S S K P +K K + RK KP+ PP
Sbjct: 257 SSSSSSSSDSDVSVKKPP--------------RGRKPAEKPLPKPRGRKPKPERPPSSSS 302
Query: 755 PENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTAL 814
++ ++ ++ E RR R R ++ ++ R E E EE+
Sbjct: 303 SDSDSDEVDRISEWKRRDEARRRELEARR--------RREQEEELRRLREQEKEEKERRR 354
Query: 815 QKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAAS 874
++ D+ E + S + ++ + K R G + RGR SS+D A
Sbjct: 355 ERADRGEAERGSGGSSGDELREDDEPVKKR--GRKGRGRGPPSSSD--------SEPEAE 404
Query: 875 EEEEEKESEEAILADDDEPCKKCG 898
E E K+S + + EP +K G
Sbjct: 405 LEREAKKSAKKPQSSSTEPARKPG 428
Score = 43.5 bits (101), Expect = 0.001
Identities = 96/479 (20%), Positives = 173/479 (36%), Gaps = 99/479 (20%)
Query: 467 TKEESYSPSKDRNIITEGNGTESLNSVITSMKTGEL---EKETAPLRKDADSSISVLEIH 523
++EE+ S + ++ + T + + + + G L +K+ AP D+DS
Sbjct: 185 SEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKAD----- 239
Query: 524 SQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILE 583
+ +P+P M S SS S ++ SS ++K K P+ +K P+
Sbjct: 240 ---SDGAKPEPVAMARSASSS-------SSSSSSSDSDVSVK---KPPRGRKPAEKPL-- 284
Query: 584 CLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLAS 643
PK KP P ++ +S + D ++++
Sbjct: 285 ---------------------------PKPRGRKPKPERPPSSSSSDSDS--DEVDRISE 315
Query: 644 EKEVVECQSTSTVGGQSVKKVD-----LETLKEDSEFTKVEMDNLDNAQTSG-------- 690
K E + + ++ + E KE+ E + D + + SG
Sbjct: 316 WKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELR 375
Query: 691 -IEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSP 749
+EP + +G + + P + + E+ E +K K + +KP
Sbjct: 376 EDDEPVKKRGRKGRGRG-----PPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQK 430
Query: 750 PKVLEPENKQ-------EKTEKEEEKTNVGRTL--RRSPRISRPTAKV-AEIR------- 792
K + PE KQ E+T K E ++ R + ++ P + K+ +EI+
Sbjct: 431 EKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDS 490
Query: 793 -DQKADKKRGEGEDEVEEESTALQK-TDKKEILK-----KSEKDTNSKVSKVKPKGKVRW 845
D K E ++ S LQK TD LK K+ KD K ++V + K R
Sbjct: 491 PDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRV 550
Query: 846 TGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPE 904
G + K + + EK + EE E+A +D+P P + E
Sbjct: 551 LGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKA----EDKPSTDLSAPVNGE 605
Score = 37.0 bits (84), Expect = 0.14
Identities = 51/253 (20%), Positives = 104/253 (41%), Gaps = 42/253 (16%)
Query: 227 SPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKEL 286
S S + E + E E K ++ +S + +P E K+ + +EK+
Sbjct: 395 SSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKE-------------KRVRPEEKQQ 441
Query: 287 VKLPVIVKLEKPLPE--NEEKKIIKEESDSFKENVKPIKVEVK-ECRADPKDTKSSMEKP 343
K PV V+ + E + ++K+ K++ S +E ++ + E+K + D D K +
Sbjct: 442 AK-PVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCL--- 497
Query: 344 VAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKI--PLKKREIKLSDDFDSPVKG 401
+E G ++ + +I +K+T+ LK ++ K + ++ ++ S V G
Sbjct: 498 -----NALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLG 552
Query: 402 PLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTE--- 458
P ++V + ++ K EE+ G++L E E+ T+
Sbjct: 553 PKIEAVQKVNKAGMEKEKAEEKLA------------GEELAGEEAPQEKAEDKPSTDLSA 600
Query: 459 PIETKFYETKEES 471
P+ + K ES
Sbjct: 601 PVNGEATSQKGES 613
>gi|14249158 hepatoma-derived growth factor-related protein 2 isoform
2 [Homo sapiens]
Length = 670
Score = 82.4 bits (202), Expect = 3e-15
Identities = 89/359 (24%), Positives = 142/359 (39%), Gaps = 50/359 (13%)
Query: 990 SEDQEEKKKDSKKSKANL-LERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGR 1048
+ D+ E DS KS N L+R++ + +S R + +D+A +E +
Sbjct: 136 ASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSE 195
Query: 1049 GKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDE 1108
+ S E++ + P+R RKK++ + DSDS D
Sbjct: 196 SEKTSD---------QDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKAD------- 239
Query: 1109 FKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPK 1168
SDG++ E V + S S+ DSD R P+ R R+ P+
Sbjct: 240 ---SDGAKPEPVAMARSASSSSSSS-SSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPE 295
Query: 1169 KKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQK 1228
+ S + +S+E R SE D+ +E RRRR + + R++ +E E K
Sbjct: 296 RPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEE-----K 350
Query: 1229 SLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEE 1288
RR + R +R S +E EDDE K+ R R RG + SE + E
Sbjct: 351 ERRRERADRGEAERGSGGSSGDEL-----REDDEPVKKRGRKGRGRGPPSSSDSEPEAEL 405
Query: 1289 EEEEGKPSRKRLHRIETDEEESCDNAHGDANQPAR---DSQPRVLPSEQESTKKPYRIE 1344
E E K ++K + +PAR + RV P E++ KP ++E
Sbjct: 406 EREAKKSAKK---------------PQSSSTEPARKPGQKEKRVRPEEKQQA-KPVKVE 448
Score = 52.0 bits (123), Expect = 4e-06
Identities = 81/384 (21%), Positives = 139/384 (36%), Gaps = 60/384 (15%)
Query: 522 IHSQKAQIEEPDPPEM----ETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDK 577
+ S ++ E +P + E D MA + TA S ++ S + +
Sbjct: 98 VSSSDSEAPEANPADGSDADEDDEDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKR 157
Query: 578 RPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDH 637
+ P L+ + ++++K D D +SP EE +S+ ESEK +
Sbjct: 158 KTPALK-MSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFT----------- 205
Query: 638 CEKLASEKEVVECQSTSTVGGQSVKKVDLET---LKEDSEFTKVEMDNLDNAQTSGIEEP 694
+K V +GG+ KK + K DS+ K E + + +S
Sbjct: 206 ----PEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASS----- 256
Query: 695 SETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLE 754
S + S S K P +K K + RK KP+ PP
Sbjct: 257 SSSSSSSSDSDVSVKKPP--------------RGRKPAEKPLPKPRGRKPKPERPPSSSS 302
Query: 755 PENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTAL 814
++ ++ ++ E RR R R ++ ++ R E E EE+
Sbjct: 303 SDSDSDEVDRISEWKRRDEARRRELEARR--------RREQEEELRRLREQEKEEKERRR 354
Query: 815 QKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAAS 874
++ D+ E + S + ++ + K R G + RGR SS+D A
Sbjct: 355 ERADRGEAERGSGGSSGDELREDDEPVKKR--GRKGRGRGPPSSSD--------SEPEAE 404
Query: 875 EEEEEKESEEAILADDDEPCKKCG 898
E E K+S + + EP +K G
Sbjct: 405 LEREAKKSAKKPQSSSTEPARKPG 428
Score = 43.5 bits (101), Expect = 0.001
Identities = 96/479 (20%), Positives = 173/479 (36%), Gaps = 99/479 (20%)
Query: 467 TKEESYSPSKDRNIITEGNGTESLNSVITSMKTGEL---EKETAPLRKDADSSISVLEIH 523
++EE+ S + ++ + T + + + + G L +K+ AP D+DS
Sbjct: 185 SEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKAD----- 239
Query: 524 SQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILE 583
+ +P+P M S SS S ++ SS ++K K P+ +K P+
Sbjct: 240 ---SDGAKPEPVAMARSASSS-------SSSSSSSDSDVSVK---KPPRGRKPAEKPL-- 284
Query: 584 CLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLAS 643
PK KP P ++ +S + D ++++
Sbjct: 285 ---------------------------PKPRGRKPKPERPPSSSSSDSDS--DEVDRISE 315
Query: 644 EKEVVECQSTSTVGGQSVKKVD-----LETLKEDSEFTKVEMDNLDNAQTSG-------- 690
K E + + ++ + E KE+ E + D + + SG
Sbjct: 316 WKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELR 375
Query: 691 -IEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSP 749
+EP + +G + + P + + E+ E +K K + +KP
Sbjct: 376 EDDEPVKKRGRKGRGRG-----PPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQK 430
Query: 750 PKVLEPENKQ-------EKTEKEEEKTNVGRTL--RRSPRISRPTAKV-AEIR------- 792
K + PE KQ E+T K E ++ R + ++ P + K+ +EI+
Sbjct: 431 EKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDS 490
Query: 793 -DQKADKKRGEGEDEVEEESTALQK-TDKKEILK-----KSEKDTNSKVSKVKPKGKVRW 845
D K E ++ S LQK TD LK K+ KD K ++V + K R
Sbjct: 491 PDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRV 550
Query: 846 TGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPE 904
G + K + + EK + EE E+A +D+P P + E
Sbjct: 551 LGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKA----EDKPSTDLSAPVNGE 605
Score = 37.0 bits (84), Expect = 0.14
Identities = 51/253 (20%), Positives = 104/253 (41%), Gaps = 42/253 (16%)
Query: 227 SPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKEL 286
S S + E + E E K ++ +S + +P E K+ + +EK+
Sbjct: 395 SSSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKE-------------KRVRPEEKQQ 441
Query: 287 VKLPVIVKLEKPLPE--NEEKKIIKEESDSFKENVKPIKVEVK-ECRADPKDTKSSMEKP 343
K PV V+ + E + ++K+ K++ S +E ++ + E+K + D D K +
Sbjct: 442 AK-PVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCL--- 497
Query: 344 VAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKI--PLKKREIKLSDDFDSPVKG 401
+E G ++ + +I +K+T+ LK ++ K + ++ ++ S V G
Sbjct: 498 -----NALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLG 552
Query: 402 PLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTE--- 458
P ++V + ++ K EE+ G++L E E+ T+
Sbjct: 553 PKIEAVQKVNKAGMEKEKAEEKLA------------GEELAGEEAPQEKAEDKPSTDLSA 600
Query: 459 PIETKFYETKEES 471
P+ + K ES
Sbjct: 601 PVNGEATSQKGES 613
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 82.0 bits (201), Expect = 4e-15
Identities = 167/898 (18%), Positives = 330/898 (36%), Gaps = 153/898 (17%)
Query: 497 MKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTAL 556
++T +E + ++ S+ VL + + +P + E+ S KD +
Sbjct: 920 LETSRKSREPTGVEENKTDSLFVLPSRDDATPVRD-EPMDAESITFKSVSEKDKRERDKP 978
Query: 557 SSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLE 616
+ T + + S +KK+ + K K + +D + +R + K+ E
Sbjct: 979 KAKGDKTKRKNDGSAVSKKEN-------IVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1031
Query: 617 SEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFT 676
+ K + +++ +S I + A K E Q T V + VKK + +K + T
Sbjct: 1032 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTT 1091
Query: 677 KVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLT 736
K E N + +P + KG +K K + K V ++ ++S +K++
Sbjct: 1092 KEEKAKKPNEKN----KPLDNKGEKRKRKTEEKGVDKDFESSS-------------MKIS 1134
Query: 737 IRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKA 796
+ KP SP + +EP+ EK ++ EK + +S P K+ K
Sbjct: 1135 KLEVTEIVKP-SPKRKMEPDT--EKMDRTPEKDKIS--------LSAPAKKI------KL 1177
Query: 797 DKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWK- 855
+++ G+ E S + ++K E T+SKV + K KGKVR + T G
Sbjct: 1178 NRETGKKIGSTENISNTKEPSEKLE-------STSSKVKQEKVKGKVRRKVTGTEGSSST 1230
Query: 856 ---YSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLC--- 909
Y+S + GS KS EE+ +++ ++ +E P +I++
Sbjct: 1231 LVDYTSTSSTGGSPVRKS------EEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQ 1284
Query: 910 ------------DSCDSGYHTACLRPPLMII-------------PDGEW--------FCP 936
+ S + + P +I P+ E F
Sbjct: 1285 SKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTK 1344
Query: 937 PCQHKLLCEKLEE----------QLQDLDVALKKKERAERRKERLVYVGISIENIIPPQE 986
H+++ +++ + +D D ++ +KE E+RK N P++
Sbjct: 1345 DVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK-----------NSTQPEK 1393
Query: 987 PDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGG-- 1044
+ E+ S+++ R S + + +F D+ + D +E
Sbjct: 1394 ESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKR 1453
Query: 1045 ------------GVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLN 1092
R KD ++ ++ ++ + + ++K+ + + RK
Sbjct: 1454 RDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKA 1513
Query: 1093 DLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEED-------PPSND------DS 1139
D+ +E +S D+ D +++ V+ N ES + PP
Sbjct: 1514 TYDTKRPNEETKSVDKNPCKD--REKHVLEARNNKESSGNKLLYILNPPETQVEKEQITG 1571
Query: 1140 DTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEEN----SRDSESDFSDDF 1195
D + + + S R S L R+T + + D E +SE N +S + S D
Sbjct: 1572 QIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDL 1631
Query: 1196 SDDFVETRRRRSRRNQKRQI----NYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEE 1251
D VE + Q+ N S S +S R H SS+ES++
Sbjct: 1632 KDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQD 1691
Query: 1252 SYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEE 1309
S K ++ + K+ K+ + + + E ++ + + K S+K + + E++
Sbjct: 1692 SKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKD 1749
Score = 79.3 bits (194), Expect = 2e-14
Identities = 155/762 (20%), Positives = 285/762 (37%), Gaps = 118/762 (15%)
Query: 215 KNSSQQDNSSRESPSLEDEE---TKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVL 271
+ + + DN+ S S +DE+ T ++ + +E +E++ +K E+ D +
Sbjct: 1030 EETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKS--- 1086
Query: 272 EETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKE-ESDSFK-------ENVKP-- 321
E+ T K+EK + P+ K EK + EEK + K+ ES S K E VKP
Sbjct: 1087 EKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSP 1146
Query: 322 ---IKVEVKECRADPKDTKSSMEKPVAQEPERIEFGG------NIKSSHEITEK-----S 367
++ + ++ P+ K S+ P + E G NI ++ E +EK S
Sbjct: 1147 KRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSS 1206
Query: 368 TEETEKLKNDQQAKI----------------------PLKKREIKL-------------S 392
+ EK+K + K+ P++K E K +
Sbjct: 1207 KVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYN 1266
Query: 393 DDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVA 452
+D +P + + P ++ KD+ + EEE K I+++G V
Sbjct: 1267 NDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS-----------VI 1315
Query: 453 PNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKD 512
N T+P Y KE PS+ T+ E + + S K ++ K
Sbjct: 1316 KNVSTKPSNIVKYPEKESE--PSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKG----KT 1369
Query: 513 ADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPK 572
D SVLE + + + + PE E++LD + S + S + K +
Sbjct: 1370 KDRDYSVLEKENPEKR-KNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRAS 1428
Query: 573 TKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPS 632
+ KD P + KKT D D + S K+ L K +++
Sbjct: 1429 SNKDFTP---------NRDKKT--DYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQ 1477
Query: 633 NIIDHCEKLASEKEVVECQSTSTVGGQSVK----KVDLETLKEDSEFTKVEMDNLDNAQT 688
E+ +K + + +++ + K K +T + + E V+ + + +
Sbjct: 1478 KNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREK 1537
Query: 689 SGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKP-- 746
+E + + S +K Y L P E T E +IT + K +K ++S +
Sbjct: 1538 HVLEARNNKESS--GNKLLYILNPPE--TQVEKEQITGQIDKSTVKPKPQLSHSSRLSSD 1593
Query: 747 ---DSPPKVLEPENKQEKTE-----KEEEKT-NVGRTLR----RSPRISRPTAKVAEIRD 793
++ EP+ + +E KEEE + N+ + L+ + S TA V ++
Sbjct: 1594 LTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGI 1653
Query: 794 QKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGR 853
+ S + +T S + +SK K K K K + + +
Sbjct: 1654 SRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKK-KKKEKKKHKKHKKHKK 1712
Query: 854 WKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCK 895
K + E E S+K ++ ++ + +E DD+ K
Sbjct: 1713 HKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1754
Score = 77.0 bits (188), Expect = 1e-13
Identities = 163/779 (20%), Positives = 283/779 (36%), Gaps = 155/779 (19%)
Query: 221 DNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQ----------PMDLENRSTANV 270
D SP E K +EETPK + K S + +E+ E++ T V
Sbjct: 1012 DGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPV 1071
Query: 271 LEE--------------TTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKE-ESDSF 315
EE T K+EK + P+ K EK + EEK + K+ ES S
Sbjct: 1072 KEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSM 1131
Query: 316 K-------ENVKP-----IKVEVKECRADPKDTKSSMEKPV------AQEPERIEFGGNI 357
K E VKP ++ + ++ P+ K S+ P + ++I NI
Sbjct: 1132 KISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENI 1191
Query: 358 KSSHEITEK-----STEETEKLKNDQQAKI----------------------PLKKREIK 390
++ E +EK S + EK+K + K+ P++K E K
Sbjct: 1192 SNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEK 1251
Query: 391 -------------LSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHE 437
++D +P + + P ++ KD+ + EEE K I+++G
Sbjct: 1252 TDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKP 1311
Query: 438 GKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSM 497
V N T+P Y KE PS+ T+ E + + S
Sbjct: 1312 AS-----------VIKNVSTKPSNIVKYPEKES--EPSEKIQKFTKDVSHEIIQHEVKSS 1358
Query: 498 KTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALS 557
K ++ K D SVLE + + + + PE E++LD + S + S
Sbjct: 1359 KNSASSEK----GKTKDRDYSVLEKENPEKR-KNSTQPEKESNLDRLNEQGNFKSLSQSS 1413
Query: 558 STESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLES 617
+ K + + KD P + KKT D D + S K+ L
Sbjct: 1414 KEARTSDKHDSTRASSNKDFTP---------NRDKKT--DYDTREYSSSKRRDEKNELTR 1462
Query: 618 EKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVK----KVDLETLKEDS 673
K +++ E+ +K + + +++ + K K +T + +
Sbjct: 1463 RKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNE 1522
Query: 674 EFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGI 733
E V+ + + + +E + + S +K Y L P E T E +IT + K +
Sbjct: 1523 ETKSVDKNPCKDREKHVLEARNNKESS--GNKLLYILNPPE--TQVEKEQITGQIDKSTV 1578
Query: 734 KLTIRIS-----SRKKKPDSPPKVLEPENKQEKTE-----KEEEKT-NVGRTLR----RS 778
K ++S S ++ EP+ + +E KEEE + N+ + L+
Sbjct: 1579 KPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEK 1638
Query: 779 PRISRPTAKVAEI---RDQ----------KADKKRGEGEDEVEEESTALQKTDKKEILKK 825
+ S TA V ++ R+Q ++ G +++ + D K+ KK
Sbjct: 1639 AKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKK 1698
Query: 826 SEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEE 884
EK + K K K K T K+ +KS ++E+EKE ++
Sbjct: 1699 KEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHK-------KKKSKKNKDKEKEKEKDD 1750
Score = 66.6 bits (161), Expect = 2e-10
Identities = 161/838 (19%), Positives = 292/838 (34%), Gaps = 137/838 (16%)
Query: 556 LSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTL 615
LS+ + K KS + + + P + + + K+ ++ L+P E+ +++
Sbjct: 868 LSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNP---ELLETSR 924
Query: 616 ESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEF 675
+S +P E +T + + E ++ +S + K + + K +
Sbjct: 925 KSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDK 984
Query: 676 TKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVP---------EEETTASENTEITS 726
TK + D ++ I +P+ KG +K + + P +EET ++NT+ +S
Sbjct: 985 TKRKNDGSAVSKKENIVKPA--KGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSS 1042
Query: 727 ERQKE----GIKLTIRISSRKKKPDSPPKVLEPENKQ-EKTEKEEEKTNVGRTLRRSPRI 781
QK+ G S K+ ++ P E K K K E+ T ++
Sbjct: 1043 SSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEK 1102
Query: 782 SRPTAKVAEIRDQKADKKRGEGED-EVEEESTALQKTDKKEILK-----KSEKDTNS--- 832
++P E R +K ++K G D + E S + K + EI+K K E DT
Sbjct: 1103 NKPLDNKGEKRKRKTEEK---GVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDR 1159
Query: 833 -----KVSKVKPKGKV---RWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEK---- 880
K+S P K+ R TG + G + SN + E +S+ ++E+ K
Sbjct: 1160 TPEKDKISLSAPAKKIKLNRETGKKI-GSTENISNTKEPSEKLESTSSKVKQEKVKGKVR 1218
Query: 881 ------ESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWF 934
E + L D G P
Sbjct: 1219 RKVTGTEGSSSTLVDYTSTSSTGGSP---------------------------------- 1244
Query: 935 CPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQE 994
K EE+ +K E E + I I PQ +D E
Sbjct: 1245 ---------VRKSEEKTDTKRTVIKTME--EYNNDNTAPAEDVIIMIQVPQSKWDKDDFE 1293
Query: 995 EKKKDSKKSK--------ANLLERRSTRTRKCISY--RFDEFDEAIDEAIEDDIKEADGG 1044
+++D K ++ A++++ ST+ + Y + E E I + +D E
Sbjct: 1294 SEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQH 1353
Query: 1045 GVGRGKDISTITGHRGKDIS-TILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEE 1103
V K+ ++ + KD ++L++E E KR+ + +SNLD
Sbjct: 1354 EVKSSKNSASSEKGKTKDRDYSVLEKENPE-------------KRKNSTQPEKESNLDRL 1400
Query: 1104 ESEDEFKISDGSQDEFVVSDENPD---ESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSR 1160
+ FK S E SD++ S +D N D TD+ +R R +
Sbjct: 1401 NEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNEL 1460
Query: 1161 RLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKED 1220
R+ +P + ++ RD + D R R + K + K
Sbjct: 1461 TRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRP 1520
Query: 1221 SESDGS-QKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTD 1279
+E S K+ + +E + R S + N + ++ KE
Sbjct: 1521 NEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQ------------ 1568
Query: 1280 EYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQEST 1337
++ + KP R+ +D D A + + DS+ V E+ES+
Sbjct: 1569 --ITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESS 1624
Score = 57.4 bits (137), Expect = 1e-07
Identities = 144/795 (18%), Positives = 291/795 (36%), Gaps = 108/795 (13%)
Query: 679 EMDNLDNAQTSGIEEPSETKGSMQKSKFKYK--------LVPEEETTASENTEITSERQK 730
+ DN + + P + KG+ K K + L PE T+ ++ E T +
Sbjct: 876 QKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEEN 935
Query: 731 EGIKLTIRISSRKKKP------DSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRP 784
+ L + S P D+ + ++++K E+++ K +T R++ S
Sbjct: 936 KTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDG-SAV 994
Query: 785 TAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVR 844
+ K ++ K +++ +GE E S K K+E + K N+K S K + +
Sbjct: 995 SKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE----TPKTDNTKSSSSSQKDE-K 1049
Query: 845 WTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPE 904
TG+ + K S+ + E ++ + ++ +SE+ L +E KK N P
Sbjct: 1050 ITGTPRKAHSK-SAKEHQETKPVKEEKVKKDYSKDVKSEK--LTTKEEKAKKPNEKNKP- 1105
Query: 905 LILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERA 964
+ GE + K K EE+ D D E +
Sbjct: 1106 ----------------------LDNKGE------KRK---RKTEEKGVDKDF-----ESS 1129
Query: 965 ERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKD-------SKKSKANLLERRSTRTRK 1017
+ +L I + EPD + +KD +KK K N + + +
Sbjct: 1130 SMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTE 1189
Query: 1018 CISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKEN--- 1074
IS + ++ E+ +K+ G R K +TG G ST++D +
Sbjct: 1190 NISNTKEPSEKL--ESTSSKVKQEKVKGKVRRK----VTGTEGSS-STLVDYTSTSSTGG 1242
Query: 1075 ---KRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEE 1131
++ + +R + + + ++D+ E+ ++ D+ E D
Sbjct: 1243 SPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKST 1302
Query: 1132 DP------PSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSR 1185
P P++ + + ++P + S ++++ T + E +S +NS
Sbjct: 1303 QPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSA 1362
Query: 1186 DSESDFSDDFSDDFVETRRRRSRRNQ---KRQINYKEDSESDGSQKSLRRGKEIRRVHKR 1242
SE + D +E R+N +++ N +E + + KE R K
Sbjct: 1363 SSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKH 1422
Query: 1243 RLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHR 1302
+ + S + + + + S ++R + D ++ +K R
Sbjct: 1423 DSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPR 1482
Query: 1303 IETD-EEESCDNAHGDANQPARDSQPR--------VLPSEQESTKKPYRIESDEEEDFE- 1352
E D ++ ++ + P+RD +P P+E+ + + E+ E
Sbjct: 1483 EERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEA 1542
Query: 1353 --NVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTS 1410
N G+ L Y +++ P T + E + G+ + + PK + S+ L+S+ T
Sbjct: 1543 RNNKESSGNKLLY-ILNPPETQVEK-----EQITGQIDKSTVKPKPQLSHSSRLSSDLTR 1596
Query: 1411 GGQEAG-APEEEEDE 1424
EA P+ E +
Sbjct: 1597 ETDEAAFEPDYNESD 1611
Score = 48.5 bits (114), Expect = 5e-05
Identities = 84/404 (20%), Positives = 145/404 (35%), Gaps = 50/404 (12%)
Query: 1052 ISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKI 1111
+S GH KD +T E+ EN +K R+R +S+ L+ E E K
Sbjct: 868 LSARDGHNQKD-NTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS 926
Query: 1112 SDGSQDEFVVSDENPDESEEDPPSNDDSDT------DFCSRRLRRHPSRPMRQSRRLRRK 1165
+ + E EN +S PS DD+ D S + + R+ + + K
Sbjct: 927 REPTGVE-----ENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAK 981
Query: 1166 TPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDG 1225
K K +D +EN + V+ R RS R++ KE++
Sbjct: 982 GDKTKRKNDGSAVSKKENIVKPAKG-----PQEKVDGERERSPRSEPPIKKAKEETPKTD 1036
Query: 1226 SQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEAD 1285
+ KS ++ ++ + + SK++++ + K K K+ S D SE
Sbjct: 1037 NTKSSSSSQKDEKI-------TGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKL 1089
Query: 1286 EEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKP---YR 1342
+EE+ KP+ K E+ ++ S ++ E KP +
Sbjct: 1090 TTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRK 1149
Query: 1343 IESDEEE---------------------DFENVGKVGSPLDYSLVDLPSTNGQSPGKAI- 1380
+E D E+ + E K+GS + S PS +S +
Sbjct: 1150 MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVK 1209
Query: 1381 -ENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEED 1423
E + GK K + +S+ S ++GG EE+ D
Sbjct: 1210 QEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD 1253
Score = 37.4 bits (85), Expect = 0.11
Identities = 49/219 (22%), Positives = 86/219 (39%), Gaps = 18/219 (8%)
Query: 177 IEEQDDQDGSSWKCI-VRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEET 235
+E +++++ S K + + N E + QID +K Q +SSR S L E
Sbjct: 1540 LEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETD 1599
Query: 236 KKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKE--DEKELVKL---- 289
+ E E ES EE+ + + + L++ V+K KE D +V++
Sbjct: 1600 EAAFEPDYNESDSESNVSVKEEE----SSGNISKDLKDKIVEKAKESLDTAAVVQVGISR 1655
Query: 290 ------PVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKP 343
P + P + + + S + K + KE + K K K
Sbjct: 1656 NQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKK 1715
Query: 344 VAQEPERIEFGGNIKSSHEITEKSTE-ETEKLKNDQQAK 381
A +E K + ++K+ + E EK K+DQ+ K
Sbjct: 1716 HAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1754
Score = 34.3 bits (77), Expect = 0.89
Identities = 33/126 (26%), Positives = 48/126 (38%), Gaps = 24/126 (19%)
Query: 1157 RQSRRLRRKTPKKKYSDDDEEEESEENSRD-SESDFSDDFSDDFVETRRRR-------SR 1208
R+ RRL+ ++ K YS S S+ S S S +S F + R R
Sbjct: 643 REQRRLKEES-KSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPR 701
Query: 1209 RNQKRQINYKEDSESDGSQKSLRRGKEIRRVH---------------KRRLSSSESEESY 1253
R + + NY+ S S G +S R RR H KR + E+E Y
Sbjct: 702 RGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREY 761
Query: 1254 LSKNSE 1259
++ E
Sbjct: 762 FNRYRE 767
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 82.0 bits (201), Expect = 4e-15
Identities = 167/898 (18%), Positives = 330/898 (36%), Gaps = 153/898 (17%)
Query: 497 MKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTAL 556
++T +E + ++ S+ VL + + +P + E+ S KD +
Sbjct: 954 LETSRKSREPTGVEENKTDSLFVLPSRDDATPVRD-EPMDAESITFKSVSEKDKRERDKP 1012
Query: 557 SSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLE 616
+ T + + S +KK+ + K K + +D + +R + K+ E
Sbjct: 1013 KAKGDKTKRKNDGSAVSKKEN-------IVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1065
Query: 617 SEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFT 676
+ K + +++ +S I + A K E Q T V + VKK + +K + T
Sbjct: 1066 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTT 1125
Query: 677 KVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLT 736
K E N + +P + KG +K K + K V ++ ++S +K++
Sbjct: 1126 KEEKAKKPNEKN----KPLDNKGEKRKRKTEEKGVDKDFESSS-------------MKIS 1168
Query: 737 IRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKA 796
+ KP SP + +EP+ EK ++ EK + +S P K+ K
Sbjct: 1169 KLEVTEIVKP-SPKRKMEPDT--EKMDRTPEKDKIS--------LSAPAKKI------KL 1211
Query: 797 DKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWK- 855
+++ G+ E S + ++K E T+SKV + K KGKVR + T G
Sbjct: 1212 NRETGKKIGSTENISNTKEPSEKLE-------STSSKVKQEKVKGKVRRKVTGTEGSSST 1264
Query: 856 ---YSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLC--- 909
Y+S + GS KS EE+ +++ ++ +E P +I++
Sbjct: 1265 LVDYTSTSSTGGSPVRKS------EEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQ 1318
Query: 910 ------------DSCDSGYHTACLRPPLMII-------------PDGEW--------FCP 936
+ S + + P +I P+ E F
Sbjct: 1319 SKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTK 1378
Query: 937 PCQHKLLCEKLEE----------QLQDLDVALKKKERAERRKERLVYVGISIENIIPPQE 986
H+++ +++ + +D D ++ +KE E+RK N P++
Sbjct: 1379 DVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRK-----------NSTQPEK 1427
Query: 987 PDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGG-- 1044
+ E+ S+++ R S + + +F D+ + D +E
Sbjct: 1428 ESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKR 1487
Query: 1045 ------------GVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLN 1092
R KD ++ ++ ++ + + ++K+ + + RK
Sbjct: 1488 RDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKA 1547
Query: 1093 DLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEED-------PPSND------DS 1139
D+ +E +S D+ D +++ V+ N ES + PP
Sbjct: 1548 TYDTKRPNEETKSVDKNPCKD--REKHVLEARNNKESSGNKLLYILNPPETQVEKEQITG 1605
Query: 1140 DTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEEN----SRDSESDFSDDF 1195
D + + + S R S L R+T + + D E +SE N +S + S D
Sbjct: 1606 QIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDL 1665
Query: 1196 SDDFVETRRRRSRRNQKRQI----NYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEE 1251
D VE + Q+ N S S +S R H SS+ES++
Sbjct: 1666 KDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQD 1725
Query: 1252 SYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEE 1309
S K ++ + K+ K+ + + + E ++ + + K S+K + + E++
Sbjct: 1726 SKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKD 1783
Score = 79.3 bits (194), Expect = 2e-14
Identities = 155/762 (20%), Positives = 285/762 (37%), Gaps = 118/762 (15%)
Query: 215 KNSSQQDNSSRESPSLEDEE---TKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVL 271
+ + + DN+ S S +DE+ T ++ + +E +E++ +K E+ D +
Sbjct: 1064 EETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKS--- 1120
Query: 272 EETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKE-ESDSFK-------ENVKP-- 321
E+ T K+EK + P+ K EK + EEK + K+ ES S K E VKP
Sbjct: 1121 EKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSP 1180
Query: 322 ---IKVEVKECRADPKDTKSSMEKPVAQEPERIEFGG------NIKSSHEITEK-----S 367
++ + ++ P+ K S+ P + E G NI ++ E +EK S
Sbjct: 1181 KRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSS 1240
Query: 368 TEETEKLKNDQQAKI----------------------PLKKREIKL-------------S 392
+ EK+K + K+ P++K E K +
Sbjct: 1241 KVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYN 1300
Query: 393 DDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVA 452
+D +P + + P ++ KD+ + EEE K I+++G V
Sbjct: 1301 NDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS-----------VI 1349
Query: 453 PNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKD 512
N T+P Y KE PS+ T+ E + + S K ++ K
Sbjct: 1350 KNVSTKPSNIVKYPEKESE--PSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKG----KT 1403
Query: 513 ADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPK 572
D SVLE + + + + PE E++LD + S + S + K +
Sbjct: 1404 KDRDYSVLEKENPEKR-KNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRAS 1462
Query: 573 TKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPS 632
+ KD P + KKT D D + S K+ L K +++
Sbjct: 1463 SNKDFTP---------NRDKKT--DYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQ 1511
Query: 633 NIIDHCEKLASEKEVVECQSTSTVGGQSVK----KVDLETLKEDSEFTKVEMDNLDNAQT 688
E+ +K + + +++ + K K +T + + E V+ + + +
Sbjct: 1512 KNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREK 1571
Query: 689 SGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKP-- 746
+E + + S +K Y L P E T E +IT + K +K ++S +
Sbjct: 1572 HVLEARNNKESS--GNKLLYILNPPE--TQVEKEQITGQIDKSTVKPKPQLSHSSRLSSD 1627
Query: 747 ---DSPPKVLEPENKQEKTE-----KEEEKT-NVGRTLR----RSPRISRPTAKVAEIRD 793
++ EP+ + +E KEEE + N+ + L+ + S TA V ++
Sbjct: 1628 LTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGI 1687
Query: 794 QKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGR 853
+ S + +T S + +SK K K K K + + +
Sbjct: 1688 SRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKK-KKKEKKKHKKHKKHKK 1746
Query: 854 WKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCK 895
K + E E S+K ++ ++ + +E DD+ K
Sbjct: 1747 HKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1788
Score = 77.0 bits (188), Expect = 1e-13
Identities = 163/779 (20%), Positives = 283/779 (36%), Gaps = 155/779 (19%)
Query: 221 DNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQ----------PMDLENRSTANV 270
D SP E K +EETPK + K S + +E+ E++ T V
Sbjct: 1046 DGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPV 1105
Query: 271 LEE--------------TTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKE-ESDSF 315
EE T K+EK + P+ K EK + EEK + K+ ES S
Sbjct: 1106 KEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSM 1165
Query: 316 K-------ENVKP-----IKVEVKECRADPKDTKSSMEKPV------AQEPERIEFGGNI 357
K E VKP ++ + ++ P+ K S+ P + ++I NI
Sbjct: 1166 KISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENI 1225
Query: 358 KSSHEITEK-----STEETEKLKNDQQAKI----------------------PLKKREIK 390
++ E +EK S + EK+K + K+ P++K E K
Sbjct: 1226 SNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEK 1285
Query: 391 -------------LSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHE 437
++D +P + + P ++ KD+ + EEE K I+++G
Sbjct: 1286 TDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKP 1345
Query: 438 GKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSM 497
V N T+P Y KE PS+ T+ E + + S
Sbjct: 1346 AS-----------VIKNVSTKPSNIVKYPEKES--EPSEKIQKFTKDVSHEIIQHEVKSS 1392
Query: 498 KTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALS 557
K ++ K D SVLE + + + + PE E++LD + S + S
Sbjct: 1393 KNSASSEK----GKTKDRDYSVLEKENPEKR-KNSTQPEKESNLDRLNEQGNFKSLSQSS 1447
Query: 558 STESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLES 617
+ K + + KD P + KKT D D + S K+ L
Sbjct: 1448 KEARTSDKHDSTRASSNKDFTP---------NRDKKT--DYDTREYSSSKRRDEKNELTR 1496
Query: 618 EKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVK----KVDLETLKEDS 673
K +++ E+ +K + + +++ + K K +T + +
Sbjct: 1497 RKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNE 1556
Query: 674 EFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGI 733
E V+ + + + +E + + S +K Y L P E T E +IT + K +
Sbjct: 1557 ETKSVDKNPCKDREKHVLEARNNKESS--GNKLLYILNPPE--TQVEKEQITGQIDKSTV 1612
Query: 734 KLTIRIS-----SRKKKPDSPPKVLEPENKQEKTE-----KEEEKT-NVGRTLR----RS 778
K ++S S ++ EP+ + +E KEEE + N+ + L+
Sbjct: 1613 KPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEK 1672
Query: 779 PRISRPTAKVAEI---RDQ----------KADKKRGEGEDEVEEESTALQKTDKKEILKK 825
+ S TA V ++ R+Q ++ G +++ + D K+ KK
Sbjct: 1673 AKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKK 1732
Query: 826 SEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEE 884
EK + K K K K T K+ +KS ++E+EKE ++
Sbjct: 1733 KEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHK-------KKKSKKNKDKEKEKEKDD 1784
Score = 66.6 bits (161), Expect = 2e-10
Identities = 161/838 (19%), Positives = 292/838 (34%), Gaps = 137/838 (16%)
Query: 556 LSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTL 615
LS+ + K KS + + + P + + + K+ ++ L+P E+ +++
Sbjct: 902 LSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNP---ELLETSR 958
Query: 616 ESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEF 675
+S +P E +T + + E ++ +S + K + + K +
Sbjct: 959 KSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDK 1018
Query: 676 TKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVP---------EEETTASENTEITS 726
TK + D ++ I +P+ KG +K + + P +EET ++NT+ +S
Sbjct: 1019 TKRKNDGSAVSKKENIVKPA--KGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSS 1076
Query: 727 ERQKE----GIKLTIRISSRKKKPDSPPKVLEPENKQ-EKTEKEEEKTNVGRTLRRSPRI 781
QK+ G S K+ ++ P E K K K E+ T ++
Sbjct: 1077 SSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEK 1136
Query: 782 SRPTAKVAEIRDQKADKKRGEGED-EVEEESTALQKTDKKEILK-----KSEKDTNS--- 832
++P E R +K ++K G D + E S + K + EI+K K E DT
Sbjct: 1137 NKPLDNKGEKRKRKTEEK---GVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDR 1193
Query: 833 -----KVSKVKPKGKV---RWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEK---- 880
K+S P K+ R TG + G + SN + E +S+ ++E+ K
Sbjct: 1194 TPEKDKISLSAPAKKIKLNRETGKKI-GSTENISNTKEPSEKLESTSSKVKQEKVKGKVR 1252
Query: 881 ------ESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWF 934
E + L D G P
Sbjct: 1253 RKVTGTEGSSSTLVDYTSTSSTGGSP---------------------------------- 1278
Query: 935 CPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQE 994
K EE+ +K E E + I I PQ +D E
Sbjct: 1279 ---------VRKSEEKTDTKRTVIKTME--EYNNDNTAPAEDVIIMIQVPQSKWDKDDFE 1327
Query: 995 EKKKDSKKSK--------ANLLERRSTRTRKCISY--RFDEFDEAIDEAIEDDIKEADGG 1044
+++D K ++ A++++ ST+ + Y + E E I + +D E
Sbjct: 1328 SEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQH 1387
Query: 1045 GVGRGKDISTITGHRGKDIS-TILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEE 1103
V K+ ++ + KD ++L++E E KR+ + +SNLD
Sbjct: 1388 EVKSSKNSASSEKGKTKDRDYSVLEKENPE-------------KRKNSTQPEKESNLDRL 1434
Query: 1104 ESEDEFKISDGSQDEFVVSDENPD---ESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSR 1160
+ FK S E SD++ S +D N D TD+ +R R +
Sbjct: 1435 NEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNEL 1494
Query: 1161 RLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKED 1220
R+ +P + ++ RD + D R R + K + K
Sbjct: 1495 TRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRP 1554
Query: 1221 SESDGS-QKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTD 1279
+E S K+ + +E + R S + N + ++ KE
Sbjct: 1555 NEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQ------------ 1602
Query: 1280 EYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQEST 1337
++ + KP R+ +D D A + + DS+ V E+ES+
Sbjct: 1603 --ITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESS 1658
Score = 57.4 bits (137), Expect = 1e-07
Identities = 144/795 (18%), Positives = 291/795 (36%), Gaps = 108/795 (13%)
Query: 679 EMDNLDNAQTSGIEEPSETKGSMQKSKFKYK--------LVPEEETTASENTEITSERQK 730
+ DN + + P + KG+ K K + L PE T+ ++ E T +
Sbjct: 910 QKDNTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEEN 969
Query: 731 EGIKLTIRISSRKKKP------DSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRP 784
+ L + S P D+ + ++++K E+++ K +T R++ S
Sbjct: 970 KTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDG-SAV 1028
Query: 785 TAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVR 844
+ K ++ K +++ +GE E S K K+E + K N+K S K + +
Sbjct: 1029 SKKENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE----TPKTDNTKSSSSSQKDE-K 1083
Query: 845 WTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPE 904
TG+ + K S+ + E ++ + ++ +SE+ L +E KK N P
Sbjct: 1084 ITGTPRKAHSK-SAKEHQETKPVKEEKVKKDYSKDVKSEK--LTTKEEKAKKPNEKNKP- 1139
Query: 905 LILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERA 964
+ GE + K K EE+ D D E +
Sbjct: 1140 ----------------------LDNKGE------KRK---RKTEEKGVDKDF-----ESS 1163
Query: 965 ERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKD-------SKKSKANLLERRSTRTRK 1017
+ +L I + EPD + +KD +KK K N + + +
Sbjct: 1164 SMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTE 1223
Query: 1018 CISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKEN--- 1074
IS + ++ E+ +K+ G R K +TG G ST++D +
Sbjct: 1224 NISNTKEPSEKL--ESTSSKVKQEKVKGKVRRK----VTGTEGSS-STLVDYTSTSSTGG 1276
Query: 1075 ---KRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEE 1131
++ + +R + + + ++D+ E+ ++ D+ E D
Sbjct: 1277 SPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKST 1336
Query: 1132 DP------PSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSR 1185
P P++ + + ++P + S ++++ T + E +S +NS
Sbjct: 1337 QPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSA 1396
Query: 1186 DSESDFSDDFSDDFVETRRRRSRRNQ---KRQINYKEDSESDGSQKSLRRGKEIRRVHKR 1242
SE + D +E R+N +++ N +E + + KE R K
Sbjct: 1397 SSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKH 1456
Query: 1243 RLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHR 1302
+ + S + + + + S ++R + D ++ +K R
Sbjct: 1457 DSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPR 1516
Query: 1303 IETD-EEESCDNAHGDANQPARDSQPR--------VLPSEQESTKKPYRIESDEEEDFE- 1352
E D ++ ++ + P+RD +P P+E+ + + E+ E
Sbjct: 1517 EERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLEA 1576
Query: 1353 --NVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTS 1410
N G+ L Y +++ P T + E + G+ + + PK + S+ L+S+ T
Sbjct: 1577 RNNKESSGNKLLY-ILNPPETQVEK-----EQITGQIDKSTVKPKPQLSHSSRLSSDLTR 1630
Query: 1411 GGQEAG-APEEEEDE 1424
EA P+ E +
Sbjct: 1631 ETDEAAFEPDYNESD 1645
Score = 48.5 bits (114), Expect = 5e-05
Identities = 84/404 (20%), Positives = 145/404 (35%), Gaps = 50/404 (12%)
Query: 1052 ISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKI 1111
+S GH KD +T E+ EN +K R+R +S+ L+ E E K
Sbjct: 902 LSARDGHNQKD-NTKSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKS 960
Query: 1112 SDGSQDEFVVSDENPDESEEDPPSNDDSDT------DFCSRRLRRHPSRPMRQSRRLRRK 1165
+ + E EN +S PS DD+ D S + + R+ + + K
Sbjct: 961 REPTGVE-----ENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAK 1015
Query: 1166 TPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDG 1225
K K +D +EN + V+ R RS R++ KE++
Sbjct: 1016 GDKTKRKNDGSAVSKKENIVKPAKG-----PQEKVDGERERSPRSEPPIKKAKEETPKTD 1070
Query: 1226 SQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEAD 1285
+ KS ++ ++ + + SK++++ + K K K+ S D SE
Sbjct: 1071 NTKSSSSSQKDEKI-------TGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKL 1123
Query: 1286 EEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKP---YR 1342
+EE+ KP+ K E+ ++ S ++ E KP +
Sbjct: 1124 TTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRK 1183
Query: 1343 IESDEEE---------------------DFENVGKVGSPLDYSLVDLPSTNGQSPGKAI- 1380
+E D E+ + E K+GS + S PS +S +
Sbjct: 1184 MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVK 1243
Query: 1381 -ENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEED 1423
E + GK K + +S+ S ++GG EE+ D
Sbjct: 1244 QEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD 1287
Score = 37.7 bits (86), Expect = 0.081
Identities = 40/168 (23%), Positives = 59/168 (35%), Gaps = 26/168 (15%)
Query: 1115 SQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDD 1174
S++EF E E+ D+ DF + + R+ R K+P YS
Sbjct: 637 SREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSP---YSGS 693
Query: 1175 DEEEESEENSRD-SESDFSDDFSDDFVETRRRR-------SRRNQKRQINYKEDSESDGS 1226
S S+ S S S +S F + R RR + + NY+ S S G
Sbjct: 694 SYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGY 753
Query: 1227 QKSLRRGKEIRRVH---------------KRRLSSSESEESYLSKNSE 1259
+S R RR H KR + E+E Y ++ E
Sbjct: 754 HRSRSRSPPYRRYHSRSRSPQAFRGQSPNKRNVPQGETEREYFNRYRE 801
Score = 37.4 bits (85), Expect = 0.11
Identities = 49/219 (22%), Positives = 86/219 (39%), Gaps = 18/219 (8%)
Query: 177 IEEQDDQDGSSWKCI-VRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEET 235
+E +++++ S K + + N E + QID +K Q +SSR S L E
Sbjct: 1574 LEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETD 1633
Query: 236 KKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKE--DEKELVKL---- 289
+ E E ES EE+ + + + L++ V+K KE D +V++
Sbjct: 1634 EAAFEPDYNESDSESNVSVKEEE----SSGNISKDLKDKIVEKAKESLDTAAVVQVGISR 1689
Query: 290 ------PVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKP 343
P + P + + + S + K + KE + K K K
Sbjct: 1690 NQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHKK 1749
Query: 344 VAQEPERIEFGGNIKSSHEITEKSTE-ETEKLKNDQQAK 381
A +E K + ++K+ + E EK K+DQ+ K
Sbjct: 1750 HAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1788
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 81.6 bits (200), Expect = 5e-15
Identities = 243/1211 (20%), Positives = 468/1211 (38%), Gaps = 207/1211 (17%)
Query: 136 KFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVRNR 195
K ++I E++ L+ + +K+ L + D N+ M IE Q++ +
Sbjct: 1044 KIFSLIQEKNELQQMLESVIAEKEQL----KTDLKENIEMTIENQEE--------LRLLG 1091
Query: 196 NELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKS 255
+EL + ++ + + + K R + E EE KE+ QE+Q++ ++
Sbjct: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLA---EVEEKLKEKSQQLQEKQQQLLNVQE 1148
Query: 256 EEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPE----NEEKKIIKEE 311
E M + N+ E K+ + E +L + KL + E +E+K++KE
Sbjct: 1149 EMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKEL 1208
Query: 312 SDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEK----- 366
SF+ ++ ++E A TK ++ E E ++ S ++EK
Sbjct: 1209 QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS--VSEKTAQII 1266
Query: 367 STEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKD-EIKQEEETC 425
+T++ EK Q +IP+ E +L P K V+ T+E + + E+ E+ T
Sbjct: 1267 NTQDLEKSHTKLQEEIPVLHEEQELL---------PNVKEVSETQETMNELELLTEQSTT 1317
Query: 426 KRISTITALGHEGKQL-VNGEVSDERV------APNFKT--EPIETKFYETKEE------ 470
K +T+ + E +L + S E + N KT E +E K + KE
Sbjct: 1318 KDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA 1377
Query: 471 --SYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADS---SISVLEIHSQ 525
S SK + +++ M+ + K++A LR + + S + E H +
Sbjct: 1378 KIQESQSKQEQSLNMKEKDNETTKIVSEMEQFK-PKDSALLRIEIEMLGLSKRLQESHDE 1436
Query: 526 KAQI--EEPDPPEMETSLDSSE----------MAKDLSSKTALSSTESCTMKGEEKSPKT 573
+ E+ D ++ L S +AK L ++ L C + EE +
Sbjct: 1437 MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496
Query: 574 K---KDKRPPI------LECL-EKLEKSKKTFLDKDAQ----RLSPIPEEVPKSTLESEK 619
+ +K I LE + +KL+ + +K+ Q ++S + E+V + E
Sbjct: 1497 RVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEH 1556
Query: 620 PGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVE 679
+ ++A S S +++ +L +E ++ + + E +K E ++E
Sbjct: 1557 RKAKDSALQSIESKMLELTNRLQESQEEIQ-----------IMIKEKEEMKRVQEALQIE 1605
Query: 680 MDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTAS----ENTEITSERQK----- 730
D L + + E ++ K S +K K+ ET E+ + E QK
Sbjct: 1606 RDQL---KENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662
Query: 731 ---EGIKLTIRISSRKKKPDSPPKVLEPENKQEKT---EKEEEKTNVGRTLRRSPRISRP 784
E I+LT + ++ S K + E+T E+++ K N+ T I+R
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRET------ITRD 1716
Query: 785 TAKVAEIRDQKADKKRGEGEDEVEE-ESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKV 843
K E++ K E ++ +++ +KT++ ++K + +N + K +
Sbjct: 1717 LEKQEELKIVHMHLK--EHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQE 1774
Query: 844 RWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHP 903
+ + + + D+ G SEK+ S +++ E+ A L + + K N
Sbjct: 1775 ELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELK----ANEH 1830
Query: 904 ELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLL-CEKLEEQLQDLDVALKKKE 962
+LI L + Q K+ E+L++Q++D + L K E
Sbjct: 1831 QLITLKKDVNE-----------------------TQKKVSEMEQLKKQIKDQSLTLSKLE 1867
Query: 963 RAERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYR 1022
IEN+ Q+ + E+ K K + NL R + +
Sbjct: 1868 ---------------IENLNLAQK---LHENLEEMKSVMKERDNL-----RRVEETLKLE 1904
Query: 1023 FDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAA 1082
D+ E++ E D++ +++ T + +L +E KE R
Sbjct: 1905 RDQLKESLQETKARDLEIQ--------QELKT---------ARMLSKEHKETVDKLREKI 1947
Query: 1083 ARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTD 1142
+ +K +++D+ D LD+ + E + KI + + E + +ED + +
Sbjct: 1948 S--EKTIQISDIQKD--LDKSKDELQKKIQELQKKELQLL-----RVKEDVNMSHKKINE 1998
Query: 1143 FCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFS---DDF 1199
+ + QS R+ KK + EE RD + D F
Sbjct: 1999 MEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQF 2058
Query: 1200 VETRRRR-SRRNQKRQINYKEDSESDGSQ---KSLRRGKEIRRVHKRRLSSSESEESYLS 1255
+ T R +R Q Q+ ++ SDG Q +SLR ++ R+ + SE ++ Y
Sbjct: 2059 IATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLR--EKCSRIKELLKRYSEMDDHYEC 2116
Query: 1256 KNSEDDELAKE 1266
N +L KE
Sbjct: 2117 LNRLSLDLEKE 2127
Score = 65.9 bits (159), Expect = 3e-10
Identities = 155/821 (18%), Positives = 335/821 (40%), Gaps = 88/821 (10%)
Query: 60 NGEVPKELV---ELHLK---LMRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLE 113
+G+VPK+L+ EL K L +++ K V + + + + E S + E+E+ L
Sbjct: 705 DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPS-EVER---LR 760
Query: 114 MSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMY----WYQLDQ 169
++ K L + + + F ++++E L+ IG+ KD L + DQ
Sbjct: 761 KEIQDKSEELHIITS---EKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQ 817
Query: 170 DHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPS 229
+ + +Q +K ++ + + + L + + + S ++
Sbjct: 818 EFQNFKTLHMDFEQ---KYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE 874
Query: 230 LEDEETKKEEETPKQEEQKES-EKMKSEEQPMDLENRSTANVLEET-----TVKKEKEDE 283
L+++ + +E + E+ KE E S Q ++ E L++T T+ +EK+D
Sbjct: 875 LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL 934
Query: 284 KELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKP 343
K+L + +++E+ +++ + D+ +E ++ +K+ + KS + +
Sbjct: 935 KQLQE---SLQIERDQLKSDIHDTVNMNIDT-QEQLRNALESLKQHQETINTLKSKISEE 990
Query: 344 VAQEPERIEFGGNIKSSHEITEKSTEETEKL--KNDQQAKIPLKKREI------KLSDDF 395
V++ E G K + ++ + L KN Q +K EI S
Sbjct: 991 VSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQ 1050
Query: 396 DSPVKGPLCKSVTPTKEFLKDEIKQE-EETCKRISTITALGHEGKQLVNGEVSDERVAPN 454
+ + +SV KE LK ++K+ E T + + LG E K+ ++ A
Sbjct: 1051 EKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIK 1110
Query: 455 FKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSM--KTGELEKETAPLRKD 512
+ E T + E K + + + ++ ++ M K E+E L+
Sbjct: 1111 KEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK-- 1168
Query: 513 ADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKG-----E 567
+ +++ + +++ ++ + E ++ K L TE ++G E
Sbjct: 1169 -NKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIE 1227
Query: 568 EKSPKTKKDKRPP---ILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPE 624
+TK++ + + E E +++ +++ +K AQ ++ E + L+ E P E
Sbjct: 1228 ATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHE 1287
Query: 625 AAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLD 684
E P + ++ +E E++ QST T ++ ++++E L+ + +F
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQST-TKDSTTLARIEMERLRLNEKF--------- 1337
Query: 685 NAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTI-RISSRK 743
+E E S+ K + K T E E+ ++ KE I+ T+ +I +
Sbjct: 1338 -------QESQEEIKSLTKERDNLK-------TIKEALEVKHDQLKEHIRETLAKIQESQ 1383
Query: 744 KKPDSPPKVLEPENKQEK--TEKEEEKTNVGRTLR-------RSPRISRPTAKVAEIRDQ 794
K + + E +N+ K +E E+ K LR S R+ ++ + +
Sbjct: 1384 SKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE 1443
Query: 795 KADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVS 835
K D +R ++ ++ ES L++ K+ + K E + KV+
Sbjct: 1444 KDDLQR--LQEVLQSESDQLKENIKEIVAKHLETEEELKVA 1482
Score = 58.9 bits (141), Expect = 3e-08
Identities = 161/850 (18%), Positives = 324/850 (38%), Gaps = 114/850 (13%)
Query: 214 LKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEE 273
LK + N+ + S E EE + + + +KM ++ DLE ++T +
Sbjct: 973 LKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL--- 1029
Query: 274 TTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEE--SDSFKENVKPIKVEVKECRA 331
T K+ E ++ K+ +++ + L + E I ++E KEN++ +E R
Sbjct: 1030 TADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRL 1089
Query: 332 DPKDTKSSMEKPVAQEPERIEFGGNIKSS----HEITEKSTEETEKLKNDQQAKIPLKKR 387
+ K E ++ I+ G + + E+ EK E++++L+ QQ + +++
Sbjct: 1090 LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEE 1149
Query: 388 EIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVS 447
++ + E LK+E+K +E T + + T
Sbjct: 1150 MSEMQKKINE-------------IENLKNELKNKELTLEHMET----------------- 1179
Query: 448 DERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETA 507
ER+ + K E EE S +K+R ++ E +S + ++ E E
Sbjct: 1180 -ERL-------ELAQKLNENYEEVKSITKERKVLKELQ--KSFETERDHLRGYIREIEAT 1229
Query: 508 PLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGE 567
L+ + I+ + + + I+E E + S T L + +
Sbjct: 1230 GLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQ 1289
Query: 568 EKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAE 627
E P K+ E + +LE + KD+ L+ I E + + ++ +
Sbjct: 1290 ELLPNVKEVSETQ--ETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 628 TSPPSNIIDHCEKLASEKEVVECQSTSTVG----GQSVKKVDLETLKEDSEFTKV--EMD 681
T N+ E L + + ++ T+ QS ++ L ++D+E TK+ EM+
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEME 1407
Query: 682 NLDNAQTSGIEEPSETKG---SMQKSKFKYKLVPEEETTASENTEI---TSERQKEGIKL 735
++ + E G +Q+S + K V +E+ E+ S++ KE IK
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIK- 1466
Query: 736 TIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQK 795
I ++ + + KV K+++ E + N+ + IS ++ I D+
Sbjct: 1467 --EIVAKHLETEEELKVAHCCLKEQEETINELRVNLS---EKETEISTIQKQLEAINDKL 1521
Query: 796 ADKKRGEGEDE----VEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTR 851
+K + E E +++ S +K ++ + K+ K +S + ++ K
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESK----------- 1570
Query: 852 GRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELIL-LCD 910
+ + S E E+EE K +EA+ + D+ + N E++ + +
Sbjct: 1571 ---MLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKE-----NTKEIVAKMKE 1622
Query: 911 SCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKER 970
S + Y L + E C+ E L+EQ + + L+ E R +
Sbjct: 1623 SQEKEYQF------LKMTAVNETQEKMCE----IEHLKEQFETQKLNLENIETENIRLTQ 1672
Query: 971 LVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTR--------KCISYR 1022
+++ + + + D +E K + + K NL R T TR K +
Sbjct: 1673 ILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENL---RETITRDLEKQEELKIVHMH 1729
Query: 1023 FDEFDEAIDE 1032
E E ID+
Sbjct: 1730 LKEHQETIDK 1739
Score = 36.2 bits (82), Expect = 0.23
Identities = 94/458 (20%), Positives = 172/458 (37%), Gaps = 71/458 (15%)
Query: 365 EKSTEETEKLKNDQQ-AKIPLKK-REIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQ-- 420
EK E K+++ QQ +P ++ R++KL+ + D ++ L +K E +Q
Sbjct: 2203 EKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVL 2262
Query: 421 --EEETCKRISTITALGHEGKQLVNG-EVSDERVAP-----NFKTEPIETKFYETKEESY 472
+E + + + ++L NG + ++R+ N + I + E +E S
Sbjct: 2263 SNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSA 2322
Query: 473 SPSK----DRNIITEGNGT--ESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQK 526
+ SK D + E N ++ ++ TS+ +G T K+ + ++ ++K
Sbjct: 2323 TISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEK 2382
Query: 527 AQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLE 586
+ E E + S E +K + + L T K + K ++ K CLE
Sbjct: 2383 IRELENSLHEAKESAMHKE-SKIIKMQKELEVTNDIIAKLQAKVHESNK--------CLE 2433
Query: 587 KLEKSKKTFLDKDAQRLSPIPEEVP-------KSTLESEKPGSPEAAETSPPSNIIDHCE 639
K +++ + DK A P EE+ K LE K E S +++
Sbjct: 2434 KTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEY-- 2491
Query: 640 KLASEKEVV-----------ECQSTS---------------TVGGQS--VKKVDLETLKE 671
+KEV+ + Q TS T GG S V+ LK
Sbjct: 2492 ----QKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKS 2547
Query: 672 DSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKE 731
+ + E+ L I++ +E + Q + K E + ++T E +
Sbjct: 2548 EHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPK 2607
Query: 732 GIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKT 769
K+T + KK P + N Q+ KE K+
Sbjct: 2608 SPKVT---GTASKKKQITPSQCKERNLQDPVPKESPKS 2642
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 81.6 bits (200), Expect = 5e-15
Identities = 157/722 (21%), Positives = 271/722 (37%), Gaps = 112/722 (15%)
Query: 233 EETKKEEETPKQEE--QKESEKMKSEEQPMDLENRSTANVLEE-----TTVKKEKEDEKE 285
E + ++ P Q + +K+ +++K+E + + LE +E+ TT +K++E + E
Sbjct: 1142 ESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLE 1201
Query: 286 LVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSME-KPV 344
K + + +KPLPE EKK+I EE E KP+ ++E + P+D K E K
Sbjct: 1202 KDKASALQE-KKPLPE--EKKLIPEEEKIRSEEKKPL---LEEKKPTPEDKKLLPEAKTS 1255
Query: 345 AQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLC 404
A E ++ + +KS +I E+ E K Q+ K P K E S L
Sbjct: 1256 APEEQKHDL---LKSQVQIAEEKLEGRVAPKTVQEGKQPQTKME-----GLPSGTPQSLP 1307
Query: 405 KSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETK- 463
K T + +K+ Q + C G E E D++ + +P +
Sbjct: 1308 KEDDKTTKTIKE---QPQPPCTAKPDQVEPGKE-----KTEKEDDKSDTSSSQQPKSPQG 1359
Query: 464 FYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAP-----LRKDADSSIS 518
+T S S I T+ ++ +K +E++P L K + +S
Sbjct: 1360 LSDTGYSSDGISSSLGEIPSLIPTDE-KDILKGLKKDSFSQESSPSSPSDLAKLESTVLS 1418
Query: 519 VLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTM-------KGEEKSP 571
+LE + E+ + + S E KD +LS T T+ EE+
Sbjct: 1419 ILEAQASTLADEKSEKKTQPHEV-SPEQPKDQEKTQSLSETLEITISEEEIKESQEERKD 1477
Query: 572 KTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPP 631
KKD + I + EKS+ F+D R P + V +S+ P TS
Sbjct: 1478 TFKKDSQQDIPSSKDHKEKSE--FVDDITTRREPY-DSVEESSESENSPVPQRKRRTSVG 1534
Query: 632 SNIIDHCEKLASE----------KEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMD 681
S+ D ++ S+ K+++E + G ED EF + ++
Sbjct: 1535 SSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASG-----------SEDDEFIRNQLK 1583
Query: 682 NLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISS 741
+ ++ S +E ++ KG + K + +L + T+ E+ E
Sbjct: 1584 EISSSTESQKKEETKGKGKITAGKHR-RLTRKSSTSIDEDAGRRHSWHDED--------- 1633
Query: 742 RKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRI-------------------- 781
+ D P++ E K + E EE G LRR I
Sbjct: 1634 -DEAFDESPELKYRETKSQ--ESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTS 1690
Query: 782 ----SRPTAKVAEIRDQKADKKRGEGEDEVEEES--TALQKTDKKEILKKSEKDTNSKVS 835
P ++ + D D+ RGEG + S T + + S+ + K
Sbjct: 1691 LYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKG 1750
Query: 836 KVKPKGKVRWTGSRTRGRWKYSSNDESEGSG-SEKSSAASEEEEEKESEEAILADDDEPC 894
+ K + K R R G + D SE E+ E+E+++E E+ +
Sbjct: 1751 ESKQQRKAR---HRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKS 1807
Query: 895 KK 896
KK
Sbjct: 1808 KK 1809
Score = 75.1 bits (183), Expect = 5e-13
Identities = 242/1289 (18%), Positives = 474/1289 (36%), Gaps = 209/1289 (16%)
Query: 188 WKCI-VRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEE 246
W C+ + + L LA + + P L ++ +S + + K++ PKQ+
Sbjct: 635 WLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDL 694
Query: 247 QKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKK 306
K E K P L + T + + K ++ E + + P K E +P ++K
Sbjct: 695 SKAPEPKK----PPPLVKQPTLH--GSPSAKAKQPPEADSLSKPAPPK-EPSVPSEQDKA 747
Query: 307 IIKEESDSFKENVKPIKVEVKECRADPK-DTKSSMEKPVAQEPERIEFGGNIKSSHEITE 365
+ ++ + VKP V A K D SS + A+E K++ +
Sbjct: 748 PVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEE----------KTTPPLKT 797
Query: 366 KSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETC 425
S + ++ + P + I + P S + ++ + D ++++EE
Sbjct: 798 DSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQV-DPVQKKEEP- 855
Query: 426 KRISTITALGHEGKQLVNGEVSDERVAPNF-KTEPIETKFYETKEESYSPSKDRNIITEG 484
K+ T + + K + G + P +T P + + +E+S S + IT+
Sbjct: 856 KKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDA 915
Query: 485 NGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEI---HSQKA----QIEEPDPPEM 537
++ T TG+L A + A + IS HSQ + P P +
Sbjct: 916 PKSQPTTPQETV--TGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQP 973
Query: 538 ETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKK-DKRPPILECLEKLEKSKKTFL 596
TS + + + + +S +K E K+P +K + + +++ E KK
Sbjct: 974 PTSQGPPKS----TGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPP 1029
Query: 597 DKDAQRLSPIPEE--VPKSTLESEKPGSP--------EAAETSPPS-NIIDHCEKLA--- 642
KD++ L+ P++ +P +S KP S PP+ N C+
Sbjct: 1030 IKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNL 1089
Query: 643 ------------SEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSG 690
E + CQ+ + GQ D+ + K
Sbjct: 1090 CGFNPTPHLTEIQEWLCLNCQTQRAISGQLG---DIRKMPPAPSGPKAS----------- 1135
Query: 691 IEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQK---EGIKLTIRISSRKKKPD 747
P T+ S QK+ + P+ + + E+ +E +K E +K T+ + +
Sbjct: 1136 -PMPVPTESSSQKTA----VPPQVKLVKKQEQEVKTEAEKVILEKVKETLSM-------E 1183
Query: 748 SPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKA----DKKRGEG 803
P ++ + KQE+++ E++K + + + P + + +IR ++ ++K+
Sbjct: 1184 KIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTP 1243
Query: 804 EDE--VEEESTALQKTDKKEILKKSEKDTNSKVS-KVKPKGKVRWTGSRTRGRWKYSSND 860
ED+ + E T+ + K ++LK + K+ +V PK +T+ S
Sbjct: 1244 EDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTP 1303
Query: 861 ESEGSGSEKSS-----------AASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLC 909
+S +K++ A ++ E E+ DD P P+ +
Sbjct: 1304 QSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGL--- 1360
Query: 910 DSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKE 969
D+GY + + L IP L+ ++ L+ L +E +
Sbjct: 1361 --SDTGYSSDGISSSLGEIPS-----------LIPTDEKDILKGLKKDSFSQESSPSSPS 1407
Query: 970 RLVYVGISIENIIPPQEPDFSEDQEEKKKD----SKKSKANLLERRSTRTRKCISYRFDE 1025
L + ++ +I+ Q ++++ EKK S + + + +S I+ +E
Sbjct: 1408 DLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEE 1467
Query: 1026 FDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGK-----DISTILD--EERKENKRPQ 1078
E+ +E + K++ +DI + H+ K DI+T + + +E+ +
Sbjct: 1468 IKESQEERKDTFKKDSQ-------QDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESE 1520
Query: 1079 RAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDD 1138
+ +RK+R + SD E+ G +++F+ ++ED ++D
Sbjct: 1521 NSPVPQRKRRTSVGSSSSDEYKQEDSQ------GSGEEEDFIRKQIIEMSADEDASGSED 1574
Query: 1139 SDTDFCSRRLRRHPSRPMRQS---------------RRLRRKTPK-------KKYSDDDE 1176
+ F +L+ S Q RRL RK+ +++S DE
Sbjct: 1575 DE--FIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDE 1632
Query: 1177 EEESEENSRDSE-SDFSDDFSDDFVETRRRRSRRNQKRQINY----KEDSESDGSQKSL- 1230
++E+ + S + + + S++ V T RR + ++N K +ES + SL
Sbjct: 1633 DDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLY 1692
Query: 1231 -------------------RRGKEIRRVHKRRLS--------SSESEESYLSKNSEDDEL 1263
RG+ +H + SS E+S S + + E
Sbjct: 1693 FDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGES 1752
Query: 1264 AKESKRSVRKRGRSTDEYSEADEEE---EEEEGKPSRKRLHRIETDEEESCDNAHGDANQ 1320
++ K R G ++ EEE EEEE +++ IE + +S
Sbjct: 1753 KQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKD 1812
Query: 1321 PARDSQPRVLPSEQESTKKPYRIESDEEE 1349
R + R P S P S EE
Sbjct: 1813 ELRAQRRRERPKTPPSNLSPIEDASPTEE 1841
Score = 68.9 bits (167), Expect = 3e-11
Identities = 236/1223 (19%), Positives = 434/1223 (35%), Gaps = 215/1223 (17%)
Query: 215 KNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEET 274
K + D+ S+ +P E ++++ P +++ + KM + DL + S+A +
Sbjct: 721 KQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMV--KPTTDLVSSSSATTKPDI 778
Query: 275 TVKKEKEDEKELVKLPVIVKLEKPL----PENEE------KKIIKEESDS--------FK 316
K + +E P+ KP P E+ K I + SDS
Sbjct: 779 PSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSS 838
Query: 317 ENVKPIKVEVKECRADPKDTKSSME-KPVAQEPERIEFGGNIKSSHEITEKSTEETEKLK 375
E+ +V+ + + +PK ++ M KP A+ + G T T T +
Sbjct: 839 ESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPK---GSPTPPGPRPTAGQTVPTPQQS 895
Query: 376 NDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALG 435
Q + ++ + L D+P P T T + + IST G
Sbjct: 896 PKPQEQS--RRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTA---G 950
Query: 436 HEGKQLVNGEVSDERVAP--------------NFKTEPIETKFYETKEESYSPSKDRNII 481
G +G + + AP + P K K+E+ +P+ ++
Sbjct: 951 QPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEK--- 1007
Query: 482 TEGNGTESLNSVITSMKTGELEKETAPLRKD----ADSSISVLEIHSQKAQIEEPDPPEM 537
E ++K E EK+ P++ A+ +VL +K+ E P
Sbjct: 1008 -----LEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLC 1062
Query: 538 ETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLD 597
+T L+ + + C + G +P + + L C + S +
Sbjct: 1063 KTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQL--- 1119
Query: 598 KDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVG 657
D +++ P P S + P E+S + KL ++E Q T
Sbjct: 1120 GDIRKMPPAPSGPKASPM-------PVPTESSSQKTAVPPQVKLVKKQE----QEVKT-- 1166
Query: 658 GQSVKKVDLETLKEDSEFTKVE-MDNLDNAQTSGIEEPSETKGSMQKSKF--KYKLVPEE 714
+KV LE +KE K+ M D Q E + +K + KL+PEE
Sbjct: 1167 --EAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEE 1224
Query: 715 ETTASEN----------------------TEITSERQKEGIKLTIRISSRKKKPDSPPKV 752
E SE T E++ + +K ++I+ K + PK
Sbjct: 1225 EKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKT 1284
Query: 753 LEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEEST 812
++ E KQ +T+ E + ++L P+ T K + + Q + D+VE
Sbjct: 1285 VQ-EGKQPQTKMEGLPSGTPQSL---PKEDDKTTKTIKEQPQPPCTAK---PDQVEPGKE 1337
Query: 813 ALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSA 872
+K D K DT+S P+G + TG YSS+ S G S
Sbjct: 1338 KTEKEDDKS-------DTSSSQQPKSPQG-LSDTG--------YSSDGISSSLGEIPSLI 1381
Query: 873 ASEEEEE-KESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDG 931
++E++ K ++ + + P L +L + L + D
Sbjct: 1382 PTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVL-----------SILEAQASTLADE 1430
Query: 932 EWFCPPCQHKLLCEKLEEQ------LQDLDVALKKKERAERRKERLVYVGISIENIIPP- 984
+ H++ E+ ++Q + L++ + ++E E ++ER + IP
Sbjct: 1431 KSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSS 1490
Query: 985 ----QEPDFSEDQEEKKK------DSKKSKANLLERRSTRTRKCIS----YRFDEFDEAI 1030
++ +F +D +++ +S +S+ + + +R RT S Y+ ++ +
Sbjct: 1491 KDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSG 1550
Query: 1031 DEA--IEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAA---RR 1085
+E I I E G + ++ K+IS+ + ++KE + + A RR
Sbjct: 1551 EEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRR 1610
Query: 1086 KKRRRLNDLDSDSN------------LDE-----------EESEDEFKISDGSQDEF--- 1119
R+ +D D+ DE +ESE+ G F
Sbjct: 1611 LTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTI 1670
Query: 1120 ----VVSDENPDES---------EEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKT 1166
++D+ ES +E+P +S TD R R S + S +
Sbjct: 1671 ELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTS 1730
Query: 1167 PKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGS 1226
P S DE+ +S + + ES + R+ R R + ++ SE
Sbjct: 1731 PTS-VSSLDEDSDSSPSHKKGESK----------QQRKARHRPHGPLLPTIEDSSE---- 1775
Query: 1227 QKSLRRGKEIRRVHKRRLSSSESEESYLSKNS--EDDELAKESKRSVRKRGRSTDEYSEA 1284
++ LR +E+ + +++ + + SK S + DEL + +R K S E
Sbjct: 1776 EEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIED 1835
Query: 1285 DEEEEEEEGKPSRKRLHRIETDE 1307
EE + LHR E
Sbjct: 1836 ASPTEELRQAAEMEELHRSSCSE 1858
Score = 65.9 bits (159), Expect = 3e-10
Identities = 207/1053 (19%), Positives = 376/1053 (35%), Gaps = 180/1053 (17%)
Query: 321 PIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQA 380
P+K E K A+ + K+ + P + E + IK S +T + + K ++
Sbjct: 995 PVKKETKAPAAEKLEPKAE-QAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSP 1053
Query: 381 K----IPLKKREIKLSDDFDSP-------VKGPLCK--SVTPTKEFLKDEIKQEEETCKR 427
K PL K E+ + D P K +C PT + + E C
Sbjct: 1054 KPESTCPLCKTELNIGSK-DPPNFNTCTECKNQVCNLCGFNPTPHLTEIQ----EWLCLN 1108
Query: 428 ISTITALGHEGKQLVNGEVSDERVAPNF----KTEPIETKFYETKEESYSPSKDRNIITE 483
T ++ ++G++ D R P K P+ + +++ P + + + +
Sbjct: 1109 CQT--------QRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQ 1160
Query: 484 GNG--TESLNSVITSMK-TGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETS 540
TE+ ++ +K T +EK + D S LE A E+ PE +
Sbjct: 1161 EQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKL 1220
Query: 541 LDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDA 600
+ E + K L EEK P T +DK+ E+ K L
Sbjct: 1221 IPEEEKIRSEEKKPLL----------EEKKP-TPEDKKLLPEAKTSAPEEQKHDLLKSQV 1269
Query: 601 QRLSPIPEE------VPKSTLESEKP-----GSPEAAETSPPSNIIDHCEKLASEKEVVE 649
Q I EE PK+ E ++P G P S P D K E+
Sbjct: 1270 Q----IAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKED-DKTTKTIKEQPQPP 1324
Query: 650 CQSTSTVGGQSVKKVDLETLKED---SEFTKVEMDNLDNAQTS-GIEE---------PSE 696
C + +K + E K D S+ K D +S GI P++
Sbjct: 1325 CTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTD 1384
Query: 697 TKG---SMQKSKFKYKLVPEEETTASE-NTEITSERQKEGIKLTIRISSRKKKP-DSPPK 751
K ++K F + P + ++ + + S + + L S +K +P + P+
Sbjct: 1385 EKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPE 1444
Query: 752 VLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEES 811
+ + K + + E T ++ S + T K +D + K E + V++ +
Sbjct: 1445 QPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDIT 1504
Query: 812 TALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSS 871
T + D E +SE NS V + K + V GS + +K ++S+GSG E+
Sbjct: 1505 TRREPYDSVEESSESE---NSPVPQRKRRTSV---GSSSSDEYK---QEDSQGSGEEEDF 1555
Query: 872 AASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDS--------------GYH 917
+ E E+A ++DDE + +L + S +S G H
Sbjct: 1556 IRKQIIEMSADEDASGSEDDEFIRN-------QLKEISSSTESQKKEETKGKGKITAGKH 1608
Query: 918 TACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVG-- 975
R I + +H E +++ D LK +E + E LV G
Sbjct: 1609 RRLTRKSSTSIDEDAGR----RHSWHDE--DDEAFDESPELKYRETKSQESEELVVTGGG 1662
Query: 976 -------ISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDE 1028
I + + I + +S + +KK S FDE E
Sbjct: 1663 GLRRFKTIELNSTIADK---YSAESSQKKT---------------------SLYFDEEPE 1698
Query: 1029 AIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKR 1088
E++ D ++ G S+ T + LDE+ + ++ + +++K
Sbjct: 1699 LEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKA 1758
Query: 1089 RRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRL 1148
R +++ E+E + ++E + E E E+ + S++
Sbjct: 1759 RHRPHGPLLPTIEDSSEEEELR----EEEELLKEQEKQREIEQQQRKSS-------SKKS 1807
Query: 1149 RRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSR 1208
++ Q RR R KTP S ++ +EE + +E +
Sbjct: 1808 KKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEME---------------ELH 1852
Query: 1209 RNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKR----RLSSSESEESYLSKNSEDDEL- 1263
R+ + + +S+ +G + S + E+++V+K L S E+S + K L
Sbjct: 1853 RSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALK 1912
Query: 1264 -AKESKRSVRKRGRSTDEYSEADEEEEEEEGKP 1295
A+E + + + A+E +E E +P
Sbjct: 1913 SAEEMYEEMMHKTHKYKAFPAANERDEVFEKEP 1945
Score = 62.4 bits (150), Expect = 3e-09
Identities = 118/548 (21%), Positives = 210/548 (38%), Gaps = 84/548 (15%)
Query: 217 SSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLE-NRSTANVLEETT 275
SS D + ES L E + ++ E+K S EQP D E +S + LE T
Sbjct: 1404 SSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITI 1463
Query: 276 VKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKD 335
++E ++ +E K ++ +P +++ K E D +P ++
Sbjct: 1464 SEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYD--------SVEE 1515
Query: 336 TKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDF 395
+ S PV Q R G + SS E ++ ++ + + ++ ++K+ I++S D
Sbjct: 1516 SSESENSPVPQRKRRTSVGSS--SSDEYKQEDSQGSGEEEDF------IRKQIIEMSADE 1567
Query: 396 DSPVKGPLCKSVTPTKEFLKDEIK--------QEEETCKRISTITALGHEGKQLVNGEVS 447
D+ S + EF+++++K Q++E K ITA H +
Sbjct: 1568 DA--------SGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSI 1619
Query: 448 DERVAPNFK---------TEPIETKFYETKEESYSPSKDRNIITEGNG-----TESLNSV 493
DE E E K+ ETK S + ++T G G T LNS
Sbjct: 1620 DEDAGRRHSWHDEDDEAFDESPELKYRETK----SQESEELVVTGGGGLRRFKTIELNST 1675
Query: 494 ITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSK 553
I + E ++ L D + LE+ S E+ E +SL +S S
Sbjct: 1676 IADKYSAESSQKKTSLYFDEEPE---LEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPT 1732
Query: 554 TALSSTESCTMKGEEKSPKTKKDKR----------PPILECLEKLEKSKKTFLDKDAQRL 603
+ S E K ++K+ ++ P I + E+ E ++ L K+ ++
Sbjct: 1733 SVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQ 1792
Query: 604 SPIPEEVPKSTLESEKPGSPE-------AAETSPPSNI-----IDHCEKLASEKEVVECQ 651
I ++ KS+ + K E +PPSN+ E+L E+ E
Sbjct: 1793 REIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELH 1852
Query: 652 STSTVGGQSVKKVDLETLKEDSEFTK---VEMDNLDNAQTS-GIEEPSETKGSMQKSKFK 707
+S S +E+ E E + +E+ + T+ + P++ + MQK +
Sbjct: 1853 RSSC----SEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQ 1908
Query: 708 YKLVPEEE 715
L EE
Sbjct: 1909 KALKSAEE 1916
Score = 42.7 bits (99), Expect = 0.003
Identities = 71/319 (22%), Positives = 129/319 (40%), Gaps = 29/319 (9%)
Query: 357 IKSSHEITE-----KSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVT-PT 410
I SHEI + STEE KL + A L KR+ SP + P+ + +T T
Sbjct: 2036 IPESHEIVDLGTMVTSTEEERKLLDADAAYEELMKRQQMQLTPGSSPTQAPIGEDMTEST 2095
Query: 411 KEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYE--TK 468
+F D + T +S + ++ + D ++ +F TE IE ++ T+
Sbjct: 2096 MDF--DRMPDASLTSSVLSGASLTDSTSSATLS--IPDVKITQHFSTEEIEDEYVTDYTR 2151
Query: 469 EESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQ 528
E + + I+T +ES SV S ++ D+ S I+ L+
Sbjct: 2152 EIQEIIAHESLILTYSEPSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLD----SIT 2207
Query: 529 IEEPDPPEMETSLDSSEMAKDLSSKT-----ALSSTESCTMKGEEKSPKTKKDKRPPILE 583
+P +M T + SE ++SS T + E ++ + +P + I+
Sbjct: 2208 TVYTEPVDMITKFEDSE---EISSSTYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVI 2264
Query: 584 CLEKLEKS-KKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLA 642
L + S ++ + K P+ + V L SEK +A + + I++ E
Sbjct: 2265 SLSDMASSIIESVVPKPE---GPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYR 2321
Query: 643 SEKEVVECQSTSTVGGQSV 661
+KE +E + T + ++V
Sbjct: 2322 DKKE-LEAERTKSSLSETV 2339
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 81.6 bits (200), Expect = 5e-15
Identities = 157/722 (21%), Positives = 271/722 (37%), Gaps = 112/722 (15%)
Query: 233 EETKKEEETPKQEE--QKESEKMKSEEQPMDLENRSTANVLEE-----TTVKKEKEDEKE 285
E + ++ P Q + +K+ +++K+E + + LE +E+ TT +K++E + E
Sbjct: 1142 ESSSQKTAVPPQVKLVKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLE 1201
Query: 286 LVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSME-KPV 344
K + + +KPLPE EKK+I EE E KP+ ++E + P+D K E K
Sbjct: 1202 KDKASALQE-KKPLPE--EKKLIPEEEKIRSEEKKPL---LEEKKPTPEDKKLLPEAKTS 1255
Query: 345 AQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLC 404
A E ++ + +KS +I E+ E K Q+ K P K E S L
Sbjct: 1256 APEEQKHDL---LKSQVQIAEEKLEGRVAPKTVQEGKQPQTKME-----GLPSGTPQSLP 1307
Query: 405 KSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETK- 463
K T + +K+ Q + C G E E D++ + +P +
Sbjct: 1308 KEDDKTTKTIKE---QPQPPCTAKPDQVEPGKE-----KTEKEDDKSDTSSSQQPKSPQG 1359
Query: 464 FYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAP-----LRKDADSSIS 518
+T S S I T+ ++ +K +E++P L K + +S
Sbjct: 1360 LSDTGYSSDGISSSLGEIPSLIPTDE-KDILKGLKKDSFSQESSPSSPSDLAKLESTVLS 1418
Query: 519 VLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTM-------KGEEKSP 571
+LE + E+ + + S E KD +LS T T+ EE+
Sbjct: 1419 ILEAQASTLADEKSEKKTQPHEV-SPEQPKDQEKTQSLSETLEITISEEEIKESQEERKD 1477
Query: 572 KTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPP 631
KKD + I + EKS+ F+D R P + V +S+ P TS
Sbjct: 1478 TFKKDSQQDIPSSKDHKEKSE--FVDDITTRREPY-DSVEESSESENSPVPQRKRRTSVG 1534
Query: 632 SNIIDHCEKLASE----------KEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMD 681
S+ D ++ S+ K+++E + G ED EF + ++
Sbjct: 1535 SSSSDEYKQEDSQGSGEEEDFIRKQIIEMSADEDASG-----------SEDDEFIRNQLK 1583
Query: 682 NLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISS 741
+ ++ S +E ++ KG + K + +L + T+ E+ E
Sbjct: 1584 EISSSTESQKKEETKGKGKITAGKHR-RLTRKSSTSIDEDAGRRHSWHDED--------- 1633
Query: 742 RKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRI-------------------- 781
+ D P++ E K + E EE G LRR I
Sbjct: 1634 -DEAFDESPELKYRETKSQ--ESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTS 1690
Query: 782 ----SRPTAKVAEIRDQKADKKRGEGEDEVEEES--TALQKTDKKEILKKSEKDTNSKVS 835
P ++ + D D+ RGEG + S T + + S+ + K
Sbjct: 1691 LYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKG 1750
Query: 836 KVKPKGKVRWTGSRTRGRWKYSSNDESEGSG-SEKSSAASEEEEEKESEEAILADDDEPC 894
+ K + K R R G + D SE E+ E+E+++E E+ +
Sbjct: 1751 ESKQQRKAR---HRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKS 1807
Query: 895 KK 896
KK
Sbjct: 1808 KK 1809
Score = 75.1 bits (183), Expect = 5e-13
Identities = 242/1289 (18%), Positives = 474/1289 (36%), Gaps = 209/1289 (16%)
Query: 188 WKCI-VRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEE 246
W C+ + + L LA + + P L ++ +S + + K++ PKQ+
Sbjct: 635 WLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDL 694
Query: 247 QKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKK 306
K E K P L + T + + K ++ E + + P K E +P ++K
Sbjct: 695 SKAPEPKK----PPPLVKQPTLH--GSPSAKAKQPPEADSLSKPAPPK-EPSVPSEQDKA 747
Query: 307 IIKEESDSFKENVKPIKVEVKECRADPK-DTKSSMEKPVAQEPERIEFGGNIKSSHEITE 365
+ ++ + VKP V A K D SS + A+E K++ +
Sbjct: 748 PVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEE----------KTTPPLKT 797
Query: 366 KSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETC 425
S + ++ + P + I + P S + ++ + D ++++EE
Sbjct: 798 DSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQV-DPVQKKEEP- 855
Query: 426 KRISTITALGHEGKQLVNGEVSDERVAPNF-KTEPIETKFYETKEESYSPSKDRNIITEG 484
K+ T + + K + G + P +T P + + +E+S S + IT+
Sbjct: 856 KKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQSRRFSLNLGSITDA 915
Query: 485 NGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEI---HSQKA----QIEEPDPPEM 537
++ T TG+L A + A + IS HSQ + P P +
Sbjct: 916 PKSQPTTPQETV--TGKLFGFGASIFSQASNLISTAGQPGPHSQSGPGAPMKQAPAPSQP 973
Query: 538 ETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKK-DKRPPILECLEKLEKSKKTFL 596
TS + + + + +S +K E K+P +K + + +++ E KK
Sbjct: 974 PTSQGPPKS----TGQAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPP 1029
Query: 597 DKDAQRLSPIPEE--VPKSTLESEKPGSP--------EAAETSPPS-NIIDHCEKLA--- 642
KD++ L+ P++ +P +S KP S PP+ N C+
Sbjct: 1030 IKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNL 1089
Query: 643 ------------SEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSG 690
E + CQ+ + GQ D+ + K
Sbjct: 1090 CGFNPTPHLTEIQEWLCLNCQTQRAISGQLG---DIRKMPPAPSGPKAS----------- 1135
Query: 691 IEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQK---EGIKLTIRISSRKKKPD 747
P T+ S QK+ + P+ + + E+ +E +K E +K T+ + +
Sbjct: 1136 -PMPVPTESSSQKTA----VPPQVKLVKKQEQEVKTEAEKVILEKVKETLSM-------E 1183
Query: 748 SPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKA----DKKRGEG 803
P ++ + KQE+++ E++K + + + P + + +IR ++ ++K+
Sbjct: 1184 KIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTP 1243
Query: 804 EDE--VEEESTALQKTDKKEILKKSEKDTNSKVS-KVKPKGKVRWTGSRTRGRWKYSSND 860
ED+ + E T+ + K ++LK + K+ +V PK +T+ S
Sbjct: 1244 EDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTP 1303
Query: 861 ESEGSGSEKSS-----------AASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLC 909
+S +K++ A ++ E E+ DD P P+ +
Sbjct: 1304 QSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGL--- 1360
Query: 910 DSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKE 969
D+GY + + L IP L+ ++ L+ L +E +
Sbjct: 1361 --SDTGYSSDGISSSLGEIPS-----------LIPTDEKDILKGLKKDSFSQESSPSSPS 1407
Query: 970 RLVYVGISIENIIPPQEPDFSEDQEEKKKD----SKKSKANLLERRSTRTRKCISYRFDE 1025
L + ++ +I+ Q ++++ EKK S + + + +S I+ +E
Sbjct: 1408 DLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEE 1467
Query: 1026 FDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGK-----DISTILD--EERKENKRPQ 1078
E+ +E + K++ +DI + H+ K DI+T + + +E+ +
Sbjct: 1468 IKESQEERKDTFKKDSQ-------QDIPSSKDHKEKSEFVDDITTRREPYDSVEESSESE 1520
Query: 1079 RAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDD 1138
+ +RK+R + SD E+ G +++F+ ++ED ++D
Sbjct: 1521 NSPVPQRKRRTSVGSSSSDEYKQEDSQ------GSGEEEDFIRKQIIEMSADEDASGSED 1574
Query: 1139 SDTDFCSRRLRRHPSRPMRQS---------------RRLRRKTPK-------KKYSDDDE 1176
+ F +L+ S Q RRL RK+ +++S DE
Sbjct: 1575 DE--FIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSIDEDAGRRHSWHDE 1632
Query: 1177 EEESEENSRDSE-SDFSDDFSDDFVETRRRRSRRNQKRQINY----KEDSESDGSQKSL- 1230
++E+ + S + + + S++ V T RR + ++N K +ES + SL
Sbjct: 1633 DDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTIELNSTIADKYSAESSQKKTSLY 1692
Query: 1231 -------------------RRGKEIRRVHKRRLS--------SSESEESYLSKNSEDDEL 1263
RG+ +H + SS E+S S + + E
Sbjct: 1693 FDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGES 1752
Query: 1264 AKESKRSVRKRGRSTDEYSEADEEE---EEEEGKPSRKRLHRIETDEEESCDNAHGDANQ 1320
++ K R G ++ EEE EEEE +++ IE + +S
Sbjct: 1753 KQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKD 1812
Query: 1321 PARDSQPRVLPSEQESTKKPYRIESDEEE 1349
R + R P S P S EE
Sbjct: 1813 ELRAQRRRERPKTPPSNLSPIEDASPTEE 1841
Score = 68.9 bits (167), Expect = 3e-11
Identities = 236/1223 (19%), Positives = 434/1223 (35%), Gaps = 215/1223 (17%)
Query: 215 KNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEET 274
K + D+ S+ +P E ++++ P +++ + KM + DL + S+A +
Sbjct: 721 KQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMV--KPTTDLVSSSSATTKPDI 778
Query: 275 TVKKEKEDEKELVKLPVIVKLEKPL----PENEE------KKIIKEESDS--------FK 316
K + +E P+ KP P E+ K I + SDS
Sbjct: 779 PSSKVQSQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSS 838
Query: 317 ENVKPIKVEVKECRADPKDTKSSME-KPVAQEPERIEFGGNIKSSHEITEKSTEETEKLK 375
E+ +V+ + + +PK ++ M KP A+ + G T T T +
Sbjct: 839 ESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPK---GSPTPPGPRPTAGQTVPTPQQS 895
Query: 376 NDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALG 435
Q + ++ + L D+P P T T + + IST G
Sbjct: 896 PKPQEQS--RRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTA---G 950
Query: 436 HEGKQLVNGEVSDERVAP--------------NFKTEPIETKFYETKEESYSPSKDRNII 481
G +G + + AP + P K K+E+ +P+ ++
Sbjct: 951 QPGPHSQSGPGAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEK--- 1007
Query: 482 TEGNGTESLNSVITSMKTGELEKETAPLRKD----ADSSISVLEIHSQKAQIEEPDPPEM 537
E ++K E EK+ P++ A+ +VL +K+ E P
Sbjct: 1008 -----LEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSPKPESTCPLC 1062
Query: 538 ETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLD 597
+T L+ + + C + G +P + + L C + S +
Sbjct: 1063 KTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPHLTEIQEWLCLNCQTQRAISGQL--- 1119
Query: 598 KDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVG 657
D +++ P P S + P E+S + KL ++E Q T
Sbjct: 1120 GDIRKMPPAPSGPKASPM-------PVPTESSSQKTAVPPQVKLVKKQE----QEVKT-- 1166
Query: 658 GQSVKKVDLETLKEDSEFTKVE-MDNLDNAQTSGIEEPSETKGSMQKSKF--KYKLVPEE 714
+KV LE +KE K+ M D Q E + +K + KL+PEE
Sbjct: 1167 --EAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPEE 1224
Query: 715 ETTASEN----------------------TEITSERQKEGIKLTIRISSRKKKPDSPPKV 752
E SE T E++ + +K ++I+ K + PK
Sbjct: 1225 EKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLKSQVQIAEEKLEGRVAPKT 1284
Query: 753 LEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEEST 812
++ E KQ +T+ E + ++L P+ T K + + Q + D+VE
Sbjct: 1285 VQ-EGKQPQTKMEGLPSGTPQSL---PKEDDKTTKTIKEQPQPPCTAK---PDQVEPGKE 1337
Query: 813 ALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSA 872
+K D K DT+S P+G + TG YSS+ S G S
Sbjct: 1338 KTEKEDDKS-------DTSSSQQPKSPQG-LSDTG--------YSSDGISSSLGEIPSLI 1381
Query: 873 ASEEEEE-KESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDG 931
++E++ K ++ + + P L +L + L + D
Sbjct: 1382 PTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVL-----------SILEAQASTLADE 1430
Query: 932 EWFCPPCQHKLLCEKLEEQ------LQDLDVALKKKERAERRKERLVYVGISIENIIPP- 984
+ H++ E+ ++Q + L++ + ++E E ++ER + IP
Sbjct: 1431 KSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSS 1490
Query: 985 ----QEPDFSEDQEEKKK------DSKKSKANLLERRSTRTRKCIS----YRFDEFDEAI 1030
++ +F +D +++ +S +S+ + + +R RT S Y+ ++ +
Sbjct: 1491 KDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGSG 1550
Query: 1031 DEA--IEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAA---RR 1085
+E I I E G + ++ K+IS+ + ++KE + + A RR
Sbjct: 1551 EEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRR 1610
Query: 1086 KKRRRLNDLDSDSN------------LDE-----------EESEDEFKISDGSQDEF--- 1119
R+ +D D+ DE +ESE+ G F
Sbjct: 1611 LTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQESEELVVTGGGGLRRFKTI 1670
Query: 1120 ----VVSDENPDES---------EEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKT 1166
++D+ ES +E+P +S TD R R S + S +
Sbjct: 1671 ELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHASSFTPGTS 1730
Query: 1167 PKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGS 1226
P S DE+ +S + + ES + R+ R R + ++ SE
Sbjct: 1731 PTS-VSSLDEDSDSSPSHKKGESK----------QQRKARHRPHGPLLPTIEDSSE---- 1775
Query: 1227 QKSLRRGKEIRRVHKRRLSSSESEESYLSKNS--EDDELAKESKRSVRKRGRSTDEYSEA 1284
++ LR +E+ + +++ + + SK S + DEL + +R K S E
Sbjct: 1776 EEELREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIED 1835
Query: 1285 DEEEEEEEGKPSRKRLHRIETDE 1307
EE + LHR E
Sbjct: 1836 ASPTEELRQAAEMEELHRSSCSE 1858
Score = 65.9 bits (159), Expect = 3e-10
Identities = 207/1053 (19%), Positives = 376/1053 (35%), Gaps = 180/1053 (17%)
Query: 321 PIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQA 380
P+K E K A+ + K+ + P + E + IK S +T + + K ++
Sbjct: 995 PVKKETKAPAAEKLEPKAE-QAPTVKRTETEKKPPPIKDSKSLTAEPQKAVLPTKLEKSP 1053
Query: 381 K----IPLKKREIKLSDDFDSP-------VKGPLCK--SVTPTKEFLKDEIKQEEETCKR 427
K PL K E+ + D P K +C PT + + E C
Sbjct: 1054 KPESTCPLCKTELNIGSK-DPPNFNTCTECKNQVCNLCGFNPTPHLTEIQ----EWLCLN 1108
Query: 428 ISTITALGHEGKQLVNGEVSDERVAPNF----KTEPIETKFYETKEESYSPSKDRNIITE 483
T ++ ++G++ D R P K P+ + +++ P + + + +
Sbjct: 1109 CQT--------QRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKLVKKQ 1160
Query: 484 GNG--TESLNSVITSMK-TGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETS 540
TE+ ++ +K T +EK + D S LE A E+ PE +
Sbjct: 1161 EQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKL 1220
Query: 541 LDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDA 600
+ E + K L EEK P T +DK+ E+ K L
Sbjct: 1221 IPEEEKIRSEEKKPLL----------EEKKP-TPEDKKLLPEAKTSAPEEQKHDLLKSQV 1269
Query: 601 QRLSPIPEE------VPKSTLESEKP-----GSPEAAETSPPSNIIDHCEKLASEKEVVE 649
Q I EE PK+ E ++P G P S P D K E+
Sbjct: 1270 Q----IAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKED-DKTTKTIKEQPQPP 1324
Query: 650 CQSTSTVGGQSVKKVDLETLKED---SEFTKVEMDNLDNAQTS-GIEE---------PSE 696
C + +K + E K D S+ K D +S GI P++
Sbjct: 1325 CTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTD 1384
Query: 697 TKG---SMQKSKFKYKLVPEEETTASE-NTEITSERQKEGIKLTIRISSRKKKP-DSPPK 751
K ++K F + P + ++ + + S + + L S +K +P + P+
Sbjct: 1385 EKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPE 1444
Query: 752 VLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEES 811
+ + K + + E T ++ S + T K +D + K E + V++ +
Sbjct: 1445 QPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDIT 1504
Query: 812 TALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSS 871
T + D E +SE NS V + K + V GS + +K ++S+GSG E+
Sbjct: 1505 TRREPYDSVEESSESE---NSPVPQRKRRTSV---GSSSSDEYK---QEDSQGSGEEEDF 1555
Query: 872 AASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDS--------------GYH 917
+ E E+A ++DDE + +L + S +S G H
Sbjct: 1556 IRKQIIEMSADEDASGSEDDEFIRN-------QLKEISSSTESQKKEETKGKGKITAGKH 1608
Query: 918 TACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVG-- 975
R I + +H E +++ D LK +E + E LV G
Sbjct: 1609 RRLTRKSSTSIDEDAGR----RHSWHDE--DDEAFDESPELKYRETKSQESEELVVTGGG 1662
Query: 976 -------ISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDE 1028
I + + I + +S + +KK S FDE E
Sbjct: 1663 GLRRFKTIELNSTIADK---YSAESSQKKT---------------------SLYFDEEPE 1698
Query: 1029 AIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKR 1088
E++ D ++ G S+ T + LDE+ + ++ + +++K
Sbjct: 1699 LEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPTSVSSLDEDSDSSPSHKKGESKQQRKA 1758
Query: 1089 RRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRL 1148
R +++ E+E + ++E + E E E+ + S++
Sbjct: 1759 RHRPHGPLLPTIEDSSEEEELR----EEEELLKEQEKQREIEQQQRKSS-------SKKS 1807
Query: 1149 RRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSR 1208
++ Q RR R KTP S ++ +EE + +E +
Sbjct: 1808 KKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEME---------------ELH 1852
Query: 1209 RNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKR----RLSSSESEESYLSKNSEDDEL- 1263
R+ + + +S+ +G + S + E+++V+K L S E+S + K L
Sbjct: 1853 RSSCSEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQKALK 1912
Query: 1264 -AKESKRSVRKRGRSTDEYSEADEEEEEEEGKP 1295
A+E + + + A+E +E E +P
Sbjct: 1913 SAEEMYEEMMHKTHKYKAFPAANERDEVFEKEP 1945
Score = 62.4 bits (150), Expect = 3e-09
Identities = 118/548 (21%), Positives = 210/548 (38%), Gaps = 84/548 (15%)
Query: 217 SSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLE-NRSTANVLEETT 275
SS D + ES L E + ++ E+K S EQP D E +S + LE T
Sbjct: 1404 SSPSDLAKLESTVLSILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITI 1463
Query: 276 VKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKD 335
++E ++ +E K ++ +P +++ K E D +P ++
Sbjct: 1464 SEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSEFVDDITTRREPYD--------SVEE 1515
Query: 336 TKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDF 395
+ S PV Q R G + SS E ++ ++ + + ++ ++K+ I++S D
Sbjct: 1516 SSESENSPVPQRKRRTSVGSS--SSDEYKQEDSQGSGEEEDF------IRKQIIEMSADE 1567
Query: 396 DSPVKGPLCKSVTPTKEFLKDEIK--------QEEETCKRISTITALGHEGKQLVNGEVS 447
D+ S + EF+++++K Q++E K ITA H +
Sbjct: 1568 DA--------SGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITAGKHRRLTRKSSTSI 1619
Query: 448 DERVAPNFK---------TEPIETKFYETKEESYSPSKDRNIITEGNG-----TESLNSV 493
DE E E K+ ETK S + ++T G G T LNS
Sbjct: 1620 DEDAGRRHSWHDEDDEAFDESPELKYRETK----SQESEELVVTGGGGLRRFKTIELNST 1675
Query: 494 ITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSK 553
I + E ++ L D + LE+ S E+ E +SL +S S
Sbjct: 1676 IADKYSAESSQKKTSLYFDEEPE---LEMESLTDSPEDRSRGEGSSSLHASSFTPGTSPT 1732
Query: 554 TALSSTESCTMKGEEKSPKTKKDKR----------PPILECLEKLEKSKKTFLDKDAQRL 603
+ S E K ++K+ ++ P I + E+ E ++ L K+ ++
Sbjct: 1733 SVSSLDEDSDSSPSHKKGESKQQRKARHRPHGPLLPTIEDSSEEEELREEEELLKEQEKQ 1792
Query: 604 SPIPEEVPKSTLESEKPGSPE-------AAETSPPSNI-----IDHCEKLASEKEVVECQ 651
I ++ KS+ + K E +PPSN+ E+L E+ E
Sbjct: 1793 REIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPIEDASPTEELRQAAEMEELH 1852
Query: 652 STSTVGGQSVKKVDLETLKEDSEFTK---VEMDNLDNAQTS-GIEEPSETKGSMQKSKFK 707
+S S +E+ E E + +E+ + T+ + P++ + MQK +
Sbjct: 1853 RSSC----SEYSPSIESDPEGFEISPEKIIEVQKVYKLPTAVSLYSPTDEQSIMQKEGSQ 1908
Query: 708 YKLVPEEE 715
L EE
Sbjct: 1909 KALKSAEE 1916
Score = 42.7 bits (99), Expect = 0.003
Identities = 71/319 (22%), Positives = 129/319 (40%), Gaps = 29/319 (9%)
Query: 357 IKSSHEITE-----KSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVT-PT 410
I SHEI + STEE KL + A L KR+ SP + P+ + +T T
Sbjct: 2036 IPESHEIVDLGTMVTSTEEERKLLDADAAYEELMKRQQMQLTPGSSPTQAPIGEDMTEST 2095
Query: 411 KEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYE--TK 468
+F D + T +S + ++ + D ++ +F TE IE ++ T+
Sbjct: 2096 MDF--DRMPDASLTSSVLSGASLTDSTSSATLS--IPDVKITQHFSTEEIEDEYVTDYTR 2151
Query: 469 EESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQ 528
E + + I+T +ES SV S ++ D+ S I+ L+
Sbjct: 2152 EIQEIIAHESLILTYSEPSESATSVPPSDTPSLTSSVSSVCTTDSSSPITTLD----SIT 2207
Query: 529 IEEPDPPEMETSLDSSEMAKDLSSKT-----ALSSTESCTMKGEEKSPKTKKDKRPPILE 583
+P +M T + SE ++SS T + E ++ + +P + I+
Sbjct: 2208 TVYTEPVDMITKFEDSE---EISSSTYFPGSIIDYPEEISVSLDRTAPPDGRASADHIVI 2264
Query: 584 CLEKLEKS-KKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLA 642
L + S ++ + K P+ + V L SEK +A + + I++ E
Sbjct: 2265 SLSDMASSIIESVVPKPE---GPVADTVSTDLLISEKDPVKKAKKETGNGIILEVLEAYR 2321
Query: 643 SEKEVVECQSTSTVGGQSV 661
+KE +E + T + ++V
Sbjct: 2322 DKKE-LEAERTKSSLSETV 2339
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 77.4 bits (189), Expect = 9e-14
Identities = 64/260 (24%), Positives = 110/260 (42%), Gaps = 15/260 (5%)
Query: 1057 GHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQ 1116
GH L+ E KE +R +R A R K+RRR +D S + + S+
Sbjct: 285 GHGSSSFDRELERE-KERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSR 343
Query: 1117 DEFVVSDENPDESEEDPPSNDDSDTDFCSRR-----LRRHPSRPMRQSRRLRRKTPKKKY 1171
D + E E++ D D+ R R SR + +R R + +KK+
Sbjct: 344 DRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKH 403
Query: 1172 SDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLR 1231
+D ++ ++ RDS+ + S R R R++ R N + S S +KS +
Sbjct: 404 KEDKDDRRHRDDKRDSKKEKKHSRS-----RSRERKHRSRSRSRNAGKRSRSRSKEKSSK 458
Query: 1232 RGKEIR-RVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEE 1290
E + + +KR S S+ + K+ + + SK RKR RS + + D + +
Sbjct: 459 HKNESKEKSNKRSRSGSQGRTDSVEKSKKREH--SPSKEKSRKRSRSKERSHKRDHSDSK 516
Query: 1291 EEG-KPSRKRLHRIETDEEE 1309
++ K R+R IE + +E
Sbjct: 517 DQSDKHDRRRSQSIEQESQE 536
Score = 54.3 bits (129), Expect = 8e-07
Identities = 59/273 (21%), Positives = 112/273 (41%), Gaps = 37/273 (13%)
Query: 992 DQEEKKKDSKKSKA--NLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRG 1049
+ +E++K+ ++S++ LERR +R+R+ R D D D +E +
Sbjct: 307 EAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKEN------ 360
Query: 1050 KDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEF 1109
RG+ D+ER + +R + R K +R S ++E++ +++
Sbjct: 361 --------ERGRRRDRDYDKERGNEREKERERSRERSKEQR-----SRGEVEEKKHKED- 406
Query: 1110 KISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKK 1169
+D+ D+ D +E S S R R+H SR ++ R ++ K
Sbjct: 407 ------KDDRRHRDDKRDSKKEKKHSRSRS-------RERKHRSRSRSRNAGKRSRSRSK 453
Query: 1170 KYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKS 1229
+ S + E E++++ S S D VE ++R K + + S+ ++
Sbjct: 454 EKSSKHKNESKEKSNKRSRS--GSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRD 511
Query: 1230 LRRGKEIRRVHKRRLSSSESEESYLSKNSEDDE 1262
K+ H RR S S +ES ++ DE
Sbjct: 512 HSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
Score = 49.7 bits (117), Expect = 2e-05
Identities = 52/198 (26%), Positives = 81/198 (40%), Gaps = 20/198 (10%)
Query: 1157 RQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQIN 1216
R R R ++P++ S S S E S F + R + Q+ +
Sbjct: 253 RHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDREL-----EREKERQRLERE 307
Query: 1217 YKEDSESDGSQKSLRRGKEIRRVH--KRRLSSSESEESYLSKNSEDDELAKESKRSVRKR 1274
KE + +S+ RG E RR +R S S S + + D E KE++R R+R
Sbjct: 308 AKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERG-RRR 366
Query: 1275 GRSTDEYSEADEEEEEEEGKP---SRKRLHRIETDE----EESCDNAHGDANQPARDSQP 1327
R D+ E E E+E + S+++ R E +E E+ D H D RDS+
Sbjct: 367 DRDYDK--ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRD---DKRDSKK 421
Query: 1328 RVLPSEQESTKKPYRIES 1345
S S ++ +R S
Sbjct: 422 EKKHSRSRSRERKHRSRS 439
Score = 39.3 bits (90), Expect = 0.028
Identities = 44/206 (21%), Positives = 77/206 (37%), Gaps = 13/206 (6%)
Query: 691 IEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPP 750
+E E + +++K + K E + S + + R + + R SR +K D
Sbjct: 295 LEREKERQRLEREAKEREK---ERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR-- 349
Query: 751 KVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEE 810
++ + EKE E+ GR R R + E + K EVEE+
Sbjct: 350 -----RDRDREREKENER---GRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEK 401
Query: 811 STALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKS 870
K D++ K + K S+ + + + + SR+R K S + E S K+
Sbjct: 402 KHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKN 461
Query: 871 SAASEEEEEKESEEAILADDDEPCKK 896
+ + + S D E KK
Sbjct: 462 ESKEKSNKRSRSGSQGRTDSVEKSKK 487
Score = 33.5 bits (75), Expect = 1.5
Identities = 36/172 (20%), Positives = 63/172 (36%), Gaps = 19/172 (11%)
Query: 713 EEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVG 772
E E + + ER E K R R K+ S +V E ++K++K ++
Sbjct: 359 ENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDK-- 416
Query: 773 RTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNS 832
R ++ + SR ++ + R + + G+ +E ++ K + KE KS K + S
Sbjct: 417 RDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKE---KSNKRSRS 473
Query: 833 KVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEE 884
GS+ R S EKS S +E +
Sbjct: 474 --------------GSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRD 511
Score = 32.7 bits (73), Expect = 2.6
Identities = 32/136 (23%), Positives = 57/136 (41%), Gaps = 10/136 (7%)
Query: 758 KQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKT 817
K K EE +V R RSPR S + ++ + G G + E L++
Sbjct: 242 KDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRE---LERE 298
Query: 818 DKKEILKK--SEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASE 875
+++ L++ E++ + S+ +G R R+R R ++ S S ++ +
Sbjct: 299 KERQRLEREAKEREKERRRSRSIDRGLER---RRSRSRERHRSRSRSRDRKGDRRD--RD 353
Query: 876 EEEEKESEEAILADDD 891
E EKE+E D D
Sbjct: 354 REREKENERGRRRDRD 369
Score = 31.6 bits (70), Expect = 5.8
Identities = 29/157 (18%), Positives = 61/157 (38%), Gaps = 12/157 (7%)
Query: 215 KNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEET 274
K + + R D + +K+ + E+K + +S +RS +
Sbjct: 401 KKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHK 460
Query: 275 TVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPK 334
KEK +++ + ++ EK +E S S +++ K + + + + D
Sbjct: 461 NESKEKSNKRSR-------SGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHS 513
Query: 335 DTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEET 371
D+K +K + + IE + S E K+ +ET
Sbjct: 514 DSKDQSDKHDRRRSQSIE-----QESQEKQHKNKDET 545
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 77.0 bits (188), Expect = 1e-13
Identities = 156/740 (21%), Positives = 291/740 (39%), Gaps = 98/740 (13%)
Query: 166 QLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAE--TLALLKAQIDPVLLKNSSQQDNS 223
+++++ +++M +++ +Q+ + I + +++A + ++L ++ V+ + Q +
Sbjct: 560 RVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQT 619
Query: 224 SRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDE 283
S D T KEEE ++ Q + +K+E Q + ++ AN + EK +
Sbjct: 620 EDSLASERDRLTSKEEEL--KDIQNMNFLLKAEVQKL----QALANEQAAAAHELEKMQQ 673
Query: 284 KELVKLPVIVKLEKPLPEN-----EEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKS 338
VK I LE+ L EE KI+ +++ + K V+ ++ V E KD
Sbjct: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE--QPNKDVVE 731
Query: 339 SMEKPVAQEPERIEFGGNIKSSHEI-------------TEKS--TEETEKLK---NDQQA 380
MEK + ++ E+++ + + I TE S T+E + LK NDQ +
Sbjct: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
Query: 381 KIPLKKREIKLSDDFDSPVKG-------PLCK----------SVTPTKEFLKDEIKQEEE 423
L + K+ + D +K L K S+T + L++ +K +EE
Sbjct: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEE 851
Query: 424 TCKRISTITA-----LGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDR 478
+ + L + GK L + + +E + K E + KE S + +
Sbjct: 852 QMNTMKAVLEEKEKDLANTGKWLQDLQEENE----SLKAHVQEVAQHNLKEASSASQFEE 907
Query: 479 NIITEGNGTESLNSVITSMKTGE--LEKETAPLRKDADSS----ISVLEIHSQKAQIEEP 532
I L + +K E L +T L+ D + + ++ Q Q
Sbjct: 908 LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASS 967
Query: 533 DPPEMETSLDSSEMAKDLSSK-TALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKS 591
PP E SE K++S L S + E K D R E +E L +
Sbjct: 968 FPPHEELLKVISEREKEISGLWNELDSLKDAV----EHQRKKNNDLREKNWEAMEALAST 1023
Query: 592 KKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQ 651
+K DK + ++V LE+++ + S PSN+ EK+ EC
Sbjct: 1024 EKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1083
Query: 652 STSTVGGQSVKKVDLETLKEDSEFTKVEMD----NLDNAQTSGIEEPSETKGSMQKSKFK 707
+ T G + VK ++ + + D T ++++ A+T GI + + +++K+K
Sbjct: 1084 A-GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWK 1142
Query: 708 YKLVPEEETTASENTEITS-----ERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKT 762
K+ +T + TS ER + K + ++ + + E E T
Sbjct: 1143 VKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVT 1202
Query: 763 EKEEEKTNVGRTLRRSPRISRPTAKVA----------EIRDQKADKKRGEGEDEVEEEST 812
E E K + TL + KVA E+ K K G ++T
Sbjct: 1203 EVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAG--------DTT 1254
Query: 813 ALQKTDKKEILKKSEKDTNS 832
++ +D + SEK+T S
Sbjct: 1255 VIENSDVSPETESSEKETMS 1274
Score = 51.2 bits (121), Expect = 7e-06
Identities = 154/826 (18%), Positives = 328/826 (39%), Gaps = 149/826 (18%)
Query: 197 ELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQ--KESEKMK 254
+L++ LA+ Q+ PV L N S S+ + + K++++ P EEQ KES+ K
Sbjct: 85 KLSDALAVEDDQVAPVPL-------NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASK 137
Query: 255 ---SEEQPMDLENRST-----ANVLEETTVKKEK----EDEKELVKLPVIVKLEKPLPEN 302
+ +P+ + + T A ++ KK K + +K++ L V K ++ LP +
Sbjct: 138 IPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLH 197
Query: 303 EEKKII----KEESDSFKENVKPIKVEVKECRA-------DPKDTKSSMEKPVA------ 345
+E K K+++ S K+ + + V+ A D D+ ++K
Sbjct: 198 QETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKP 257
Query: 346 QEPERIEFGGNIKSSHEITEKSTE----------ETEKLKNDQQAKIP--LKKREIKLSD 393
+ E I+ G K E +++ E +T D+ + LK++ + D
Sbjct: 258 DQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
Query: 394 DFDSPVKGPLCKSVTPTKE------FLKDEIKQEEETCKRISTITALGHEGKQLVNGEVS 447
KG L + +E +K++ ++ CK+++ E +V +
Sbjct: 318 ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
Query: 448 DE-------------RVAPNFK-TEPIETKFYETKEESYSP----SKDRNIITEG--NGT 487
D ++ +++ T+ ++ KF + +E+ + ++ I+ + N T
Sbjct: 378 DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT 437
Query: 488 ESLNSVITSM-----------------KTGELEKETAPLRKDADSSISVLEIHSQKAQI- 529
L S ++ KTG+L++E +K+A+ + + L++ Q+A+
Sbjct: 438 NQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQ-KKNAEQAATQLKVQLQEAERR 496
Query: 530 -EEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKL 588
EE + + + +DL SK E ++ + K + L L +
Sbjct: 497 WEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
Query: 589 EKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVV 648
E+ + + ++ I E+ + ++ S AA+TS S + + K+ +EK+
Sbjct: 557 EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA-SVLAEELHKVIAEKDKQ 615
Query: 649 ECQSTSTVGGQ----SVKKVDLETLKEDSEFTKVEMDNLD---NAQTSGIEEPSETKGSM 701
Q+ ++ + + K+ +L+ ++ + K E+ L N Q + E + + S+
Sbjct: 616 IKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSV 675
Query: 702 QKSKFKYKLVPE----EETTASENTEITSERQK----EGIKLTIRISSRKKKP--DSPPK 751
K +L+ E E + E +I +++ K E KL +S + K + K
Sbjct: 676 YVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEK 735
Query: 752 VLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDE----- 806
++ ++++ KT +E +T + + + ++ + + + + D K + +
Sbjct: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASL 795
Query: 807 VEEESTALQKTDKK----------EILKKSEKDTN------SKVSKVKP--KGKVRWTGS 848
VEE + + D K E+LK + K+ SKV +++ KGK +
Sbjct: 796 VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNT 855
Query: 849 R------------TRGRWKYSSNDESEGSGSEKSSAASEEEEEKES 882
G+W +E+E + A +E S
Sbjct: 856 MKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASS 901
Score = 34.7 bits (78), Expect = 0.68
Identities = 56/279 (20%), Positives = 104/279 (37%), Gaps = 42/279 (15%)
Query: 1065 TILDEERKENKRPQRAAAAR------RKKRRRLNDLDSDSNLDEEESED---EFKISDGS 1115
T+ DE + KR Q+ + KK+ + ++ + NL E +SE +FK+SD
Sbjct: 32 TLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQN-GNLHESDSESVPRDFKLSDA- 89
Query: 1116 QDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRR----KTPKKKY 1171
V D D+ P + ++ + R+ + +P+ + + ++ K P KK
Sbjct: 90 ---LAVED---DQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKV 143
Query: 1172 ---------SDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSE 1222
+ E S++ +S D D VET S+R + ++ + E
Sbjct: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQE 203
Query: 1223 SDGSQKSLRRGKE-----------IRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSV 1271
S +K K+ I L + + K D L + +
Sbjct: 204 SGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGI 263
Query: 1272 RKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEES 1310
+K G + +E D+E E + K L + E+E+
Sbjct: 264 QKSGTKKLK-TETDKENAEVKFKDFLLSLKTMMFSEDEA 301
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 75.9 bits (185), Expect = 3e-13
Identities = 205/1013 (20%), Positives = 403/1013 (39%), Gaps = 135/1013 (13%)
Query: 215 KNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEE---QPMDLENRSTANVL 271
KN ++ N S +E KKEE+T +QE +K K+ E Q E ++ + L
Sbjct: 1023 KNLAKIRNKQEVMISDLEERLKKEEKT-RQELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081
Query: 272 EETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRA 331
+ KKE+E + L + ++ L +N K+++E ++ ++ E +
Sbjct: 1082 KLQLAKKEEELQGALARGD-----DETLHKNNALKVVRE-----------LQAQIAELQE 1125
Query: 332 DPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKI-PLKKREIK 390
D + K+S K Q+ + E +K+ E T +T ++L+ ++ ++ LKK +
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 391 LSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDE- 449
+ + ++ ++ + T +E+ ++ E KR +G + N E++ E
Sbjct: 1186 ETKNHEAQIQDMRQRHATAL-----EELSEQLEQAKRFKANLEKNKQGLETDNKELACEV 1240
Query: 450 ------RVAPNFKTEPIETKFYETKEESYSPSKDRNIITE--GNGTESLNSVITSMKTGE 501
+ K + ++ + E + + R + E L++V T ++ E
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE--E 1298
Query: 502 LEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDL------SSKTA 555
EK+ KDA S S L+ + Q E + + + E K+ + A
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 556 LSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTL 615
+ E + + + TKK K L +E LE++KK L KDA+ LS EE +
Sbjct: 1359 RKNLEKQVLALQSQLADTKK-KVDDDLGTIESLEEAKKKLL-KDAEALSQRLEEKALAYD 1416
Query: 616 ESEKPGSPEAAETSPPSNIIDHCEKLASEKE---------VVECQSTST----------- 655
+ EK + E + +DH ++AS E + E +S S
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476
Query: 656 -VGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKG-------SMQKSKFK 707
+ K + L E++ K E + + + +E+ +K ++KSK
Sbjct: 1477 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA 1536
Query: 708 YKLVPEEETTASENTEITSERQKEG-IKLTIRISSRKKKPDSPPKVLEPENKQE-----K 761
+ EE T E E + ++ ++L + + + K + + + + +N+++ K
Sbjct: 1537 LEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK 1596
Query: 762 TEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKAD-KKRGEGEDEVEEESTALQ----- 815
+E E +R+ ++ +++D +A + + DEV ++ LQ
Sbjct: 1597 QVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD 1656
Query: 816 --------KTDKKEIL---KKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEG 864
+ + EI K+SEK S +++ + + R R R DE
Sbjct: 1657 YQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR-RHAEQERDELAD 1715
Query: 865 SGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPP 924
+ +S S +EK EA +A +E ++ + LL D + L+
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEE----EQSNMELLNDR----FRKTTLQVD 1767
Query: 925 LMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPP 984
+ + ++LE Q ++L L++ E A + K + I
Sbjct: 1768 TLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK---------FKATISA 1818
Query: 985 QEPDFSEDQEEKKKDSK-KSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADG 1043
E + +E+ ++++K ++ AN L RR+ + K I + +ED+ + AD
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ-----------VEDERRHAD- 1866
Query: 1044 GGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLND-LDSDSNLDE 1102
+ K+ R K + L+E +E RA A+RRK +R L+D +++ L
Sbjct: 1867 ----QYKEQMEKANARMKQLKRQLEEAEEE---ATRANASRRKLQRELDDATEANEGLSR 1919
Query: 1103 EESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRP 1155
E S + ++ G F S + + S + SD D S+ + ++P
Sbjct: 1920 EVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQP 1972
Score = 75.1 bits (183), Expect = 5e-13
Identities = 222/1208 (18%), Positives = 455/1208 (37%), Gaps = 186/1208 (15%)
Query: 193 RNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLED-EETKKEEETPKQEEQKESE 251
R +L E +L Q+ + ++ +R + ++ EE + E+ +EE++ ++
Sbjct: 880 RKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQ 939
Query: 252 KMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEE 311
+++E++ M + L+E ++K +L K+ K++K EE +++++
Sbjct: 940 ILQNEKKKMQAHIQDLEEQLDEEEGARQK---LQLEKVTAEAKIKK---MEEEILLLEDQ 993
Query: 312 SDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEET 371
+ F + K ++ + EC + +A+E E+ + I++ E+ E
Sbjct: 994 NSKFIKEKKLMEDRIAECSSQ-----------LAEEEEKAKNLAKIRNKQEVMISDLE-- 1040
Query: 372 EKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTI 431
E+LK +++ + L+K + KL + L+D+I + + +
Sbjct: 1041 ERLKKEEKTRQELEKAKRKLDGETTD----------------LQDQIAELQAQIDELKLQ 1084
Query: 432 TALGHEGKQLVNGEVSDERVAPNFK---TEPIETKFYETKEESYSPSKDRNIITEGNGTE 488
A E Q DE + N ++ + E +E+ S RN +
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK--R 1142
Query: 489 SLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQ-IEEPDPPEMETSLDSSEMA 547
L+ + ++KT L D++ + E+ +++ Q + E E + +
Sbjct: 1143 DLSEELEALKT--------ELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQI 1194
Query: 548 KDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILE-------CLEKLEKSKKTFLDKDA 600
+D+ + A + E + K K +K LE C K+ + K +
Sbjct: 1195 QDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR 1254
Query: 601 QRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQS 660
++L +E+ E ++ A + S N +D+ L E E +
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 661 VKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASE 720
+ D + L ++ K+ + +S I + E K S+Q+ + EEE A +
Sbjct: 1315 SQLQDTQELLQEETRQKLNL-------SSRIRQLEEEKNSLQEQQ-------EEEEEARK 1360
Query: 721 NTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPR 780
N E K+ + L +++ KKK D +E + +K + L+ +
Sbjct: 1361 NLE------KQVLALQSQLADTKKKVDDDLGTIESLEEAKK-----------KLLKDAEA 1403
Query: 781 ISRPTAKVAEIRDQKADKKRGEGEDEVEEESTAL-QKTDKKEILKKSEKDTNSKVSKVKP 839
+S+ + A D K +K + + E+++ + L + L+K +K + +++ K
Sbjct: 1404 LSQRLEEKALAYD-KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK- 1461
Query: 840 KGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGL 899
R+ R R + + S + A E +EE E + L D E
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED------ 1515
Query: 900 PNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALK 959
L+ D G + L + + E++ QL++L+ L+
Sbjct: 1516 -------LMSSKDDVGKNVHELEKSKRAL------------EQQVEEMRTQLEELEDELQ 1556
Query: 960 KKERAERRKERLVYVGISIENIIPPQEPDF---SEDQEEKK----KDSKKSKANLLERRS 1012
E A+ R E ++++ + E D E EEKK K ++ +A L + R
Sbjct: 1557 ATEDAKLRLE------VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERK 1610
Query: 1013 TRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERK 1072
R S + E D ++D + + R + I + L + K
Sbjct: 1611 QRALAVASKKKMEID------LKDLEAQIEAANKARDEVIKQLRK---------LQAQMK 1655
Query: 1073 ENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGS----QDEFVVSDENPDE 1128
+ +R A A R + +ESE + K + Q+E S+
Sbjct: 1656 DYQRELEEARASR----------DEIFAQSKESEKKLKSLEAEILQLQEELASSERARRH 1705
Query: 1129 SEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESE-ENSRDS 1187
+E++ D T+ S + S + + RRL + + + ++E+ E N R
Sbjct: 1706 AEQERDELADEITNSASGK-----SALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760
Query: 1188 ESDFS-DDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSS 1246
++ D + + R + + RQ +++ E + L ++ K +S+
Sbjct: 1761 KTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGA--VKSKFKATISA 1818
Query: 1247 SESE----ESYLSKNSEDDELAKESKRSVRKRGRS-----TDEYSEADEEEEEEEGKPSR 1297
E++ E L + +++ A + R K+ + DE AD+ +E+ E +R
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANAR 1878
Query: 1298 -KRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGK 1356
K+L R + EE A ++ R L E + + S E +N +
Sbjct: 1879 MKQLKRQLEEAEEEATRA---------NASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
Query: 1357 VGSPLDYS 1364
G P+ +S
Sbjct: 1930 RGGPISFS 1937
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 74.7 bits (182), Expect = 6e-13
Identities = 111/504 (22%), Positives = 192/504 (38%), Gaps = 65/504 (12%)
Query: 954 LDVALKKKERAERRKERLVYVGISIENIIPPQEPDFS--EDQEEKKKDS----------- 1000
LD K++++ + ++ S E P QE D + ++EKK+D
Sbjct: 196 LDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIP 255
Query: 1001 ----KKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTIT 1056
K N +E + R IS +F + ++E G ++I
Sbjct: 256 YPLITKEDINAIEMEEDK-RDLISREISKFRDT-----HKKLEEEKGKKEKERQEIEKER 309
Query: 1057 GHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQ 1116
R ++ + +E +R + + K+R R + D D + +E D + D +
Sbjct: 310 RERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDR 369
Query: 1117 DEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDE 1176
D SD N D S S D R R R+ R R + +++ + E
Sbjct: 370 DRERSSDRNKDRSRSREKSRD-------RERERERERERERERERERERERERERERERE 422
Query: 1177 EEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKE---DSESDGSQKSLRRG 1233
E ++ RD E D D + RR+ R+ ++++ Y+E + E +K+
Sbjct: 423 REREKDKKRDREEDEEDAYE------RRKLERKLREKEAAYQERLKNWEIRERKKTREYE 476
Query: 1234 KEIRRVHKRRLSSSESE---ESYLSKNSEDDELAKESKRS-VRKRGRSTDEYSEADEEE- 1288
KE R +RR ++ + +L +D + K + S ++KR R ++ EADE +
Sbjct: 477 KEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDR 536
Query: 1289 --EEEEGKPSRKRL----HRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYR 1342
E+EE + R+RL H E + + QP +P E+E +K +
Sbjct: 537 KREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEK 596
Query: 1343 IESDEEEDFENVGK-VGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTAS 1401
E EE+ E K P + PS + S G A N TP D S
Sbjct: 597 REEPMEEEEEPEQKPCLKPTLRPISSAPSVSSAS-GNATPN----------TPGDESPCG 645
Query: 1402 ASLASNGTSGGQEAGAPEEEEDEL 1425
+ + Q+ PEE ++
Sbjct: 646 IIIPHENSPDQQQ---PEEHRPKI 666
Score = 47.0 bits (110), Expect = 1e-04
Identities = 128/636 (20%), Positives = 239/636 (37%), Gaps = 65/636 (10%)
Query: 198 LAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEE 257
L + A KAQ+D K + N+ E+ + +DEE EE + + K + ++ E
Sbjct: 158 LVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIRE 217
Query: 258 QPMDLENRSTANVLEETTVKKEKEDE-------KELVKLPVIVKLEKPLPENEEKK--II 308
+L S + KKEK+++ L+ P+I K + E EE K +I
Sbjct: 218 YSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLI 277
Query: 309 KEESDSFKENVKPIKVE---VKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITE 365
E F++ K ++ E ++ R + + + E+ +E ER E + E E
Sbjct: 278 SREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERE-RE 336
Query: 366 KSTE---ETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEE 422
K E E E+ ++ + K + R+ + D D K + ++E +D ++ E
Sbjct: 337 KEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERE 396
Query: 423 ETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNIIT 482
+R E ++ E ER + + + E +E++Y K +
Sbjct: 397 RERER-----EREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLR 451
Query: 483 EGNGT--ESLNS--VITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEME 538
E E L + + KT E EKE R++ E K +E+ D
Sbjct: 452 EKEAAYQERLKNWEIRERKKTREYEKEAE--REEERRREMAKEAKRLKEFLEDYDDDR-- 507
Query: 539 TSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDK 598
D + + + + L E M+ +E+ K +K E+LE+ ++ L +
Sbjct: 508 ---DDPKYYRGSALQKRLRDREK-EMEADERDRKREK----------EELEEIRQRLLAE 553
Query: 599 DAQRLSPIPE-EVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVG 657
P P+ E+ + E+E+ P+ + P S + ++ EK +
Sbjct: 554 G----HPDPDAELQRMEQEAERRRQPQIKQ-EPESEEEEEEKQEKEEKREEPMEEEEEPE 608
Query: 658 GQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETT 717
+ K L + + + N T G E P ++P E +
Sbjct: 609 QKPCLKPTLRPISSAPSVSSASGNATPN--TPGDESPCGI------------IIPHENSP 654
Query: 718 ASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRR 777
+ E R K G+ L + S+ +P+S + P + ++E+ +V R +
Sbjct: 655 DQQQPE--EHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKL 712
Query: 778 SPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTA 813
P K A ++KR + +E+ TA
Sbjct: 713 VPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTA 748
Score = 43.9 bits (102), Expect = 0.001
Identities = 93/477 (19%), Positives = 175/477 (36%), Gaps = 70/477 (14%)
Query: 670 KEDSEFTKVEMDNLD--NAQTSGIEEP----SETKGSMQKSKFKYKLVPEEETTASENTE 723
KED ++E D D + + S + E KG +K + + + E E
Sbjct: 261 KEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERER 320
Query: 724 ITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISR 783
ER++E + R ++++ + K+ +++ E+ R S R
Sbjct: 321 ERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKD 380
Query: 784 PTAKVAEIRDQKADKKR-------------GEGEDEVEEESTALQKTDKKEILKKSEKDT 830
+ + RD++ +++R E E E E E ++ DKK + E+D
Sbjct: 381 RSRSREKSRDREREREREREREREREREREREREREREREREREREKDKK---RDREEDE 437
Query: 831 NSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADD 890
+ K + K+R + + R K E + + + A EEE +E +A +
Sbjct: 438 EDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRRE-----MAKE 492
Query: 891 DEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQ 950
+ K+ L ++ + D D Y+ + + E K E+LEE
Sbjct: 493 AKRLKEF-LEDYDD-----DRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEI 546
Query: 951 LQ--------DLDVALKKKER-AERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSK 1001
Q D D L++ E+ AERR++ + QEP+ E++EEK++ +
Sbjct: 547 RQRLLAEGHPDPDAELQRMEQEAERRRQPQI-----------KQEPESEEEEEEKQEKEE 595
Query: 1002 KSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGK 1061
K + + E + C+ A ++ A G I H
Sbjct: 596 KREEPMEEEEEPEQKPCLKPTLRPISSA--PSVSSASGNATPNTPGDESPCGIIIPHENS 653
Query: 1062 DISTILDEERKENKRPQRAAAAR----------RKKRRRLNDLDSDSNLDEEESEDE 1108
D+++ E RP+ + + +R+ +DS N E+E D+
Sbjct: 654 P-----DQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDD 705
Score = 38.5 bits (88), Expect = 0.047
Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 3/70 (4%)
Query: 193 RNRNELAETLALLKAQ--IDPVLLKNSSQQDNSSRESPSLEDE-ETKKEEETPKQEEQKE 249
R + EL E L A+ DP +Q+ R P ++ E E+++EEE +++E+K
Sbjct: 538 REKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKR 597
Query: 250 SEKMKSEEQP 259
E M+ EE+P
Sbjct: 598 EEPMEEEEEP 607
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 74.7 bits (182), Expect = 6e-13
Identities = 125/653 (19%), Positives = 264/653 (40%), Gaps = 73/653 (11%)
Query: 193 RNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEK 252
R + L E L K + DP + S + ++ + E+E T+KEE++ ++E+ E E
Sbjct: 106 RRQKRLQEALERQK-EFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIE- 163
Query: 253 MKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKP----LPENEEKKII 308
++E + + E KEKE+E+E EKP + EN+ + ++
Sbjct: 164 -ETETVTKSYQKNDWRDAEENKKEDKEKEEEEE----------EKPKRGSIGENQVEVMV 212
Query: 309 KEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEP----ERIEFGGNIKSSHEIT 364
+E++ +E + + + +K + ++ K E+ + E++E ++ E
Sbjct: 213 EEKTTESQE--ETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
Query: 365 EKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEET 424
EE E++K +Q KI ++ I+ + + + + +E +++E K+ E
Sbjct: 271 RLEAEERERIKAEQDKKIADERARIEAEEKAAAQERE---RREAEERERMREEEKRAAEE 327
Query: 425 CKRISTITALGHEGKQLVNGEVSDERVA-PNFKTEPIETKFYETKEESYSPSKDRNIITE 483
+RI E +Q + E ++R A + + E + E ++ + + +++ + E
Sbjct: 328 RQRIKEEEKRAAEERQRIKEE--EKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEE 385
Query: 484 GNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDS 543
+ L +M+ +++ E + I ++ +KAQ ++ ++
Sbjct: 386 QKRNKQLEEKKHAMQETKIKGE------KVEQKIEGKWVNEKKAQEDKLQTAVLKK--QG 437
Query: 544 SEMAKDLSSKTALSSTESCTMKGEE-KSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQR 602
E + +K + T K EE K K KKDK P E ++ KK F + +Q
Sbjct: 438 EEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPK--EEVKSFMDRKKGFTEVKSQN 495
Query: 603 LSPIPEEVPKSTLESEKPG-----SPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTV- 656
+ ++ + +PG + AE +P E+L + E + +
Sbjct: 496 GEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK 555
Query: 657 GGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEET 716
Q ++LE LK+ E + ++ + + + E +++ + K +L E E
Sbjct: 556 QKQQEAALELEELKKKREERRKVLEEEEQRR-----KQEEADRKLREEEEKRRLKEEIER 610
Query: 717 TASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLR 776
+E E + ++G +S KK P K P+ K E+ E N
Sbjct: 611 RRAEAAEKRQKMPEDG------LSDDKK----PFKCFTPKGSSLKIEERAEFLNKSVQKS 660
Query: 777 RSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKD 829
+ + A V++I + +E+ ++A++ T + K + D
Sbjct: 661 SGVKSTHQAAIVSKI------------DSRLEQYTSAIEGTKSAKPTKPAASD 701
Score = 66.6 bits (161), Expect = 2e-10
Identities = 63/300 (21%), Positives = 126/300 (42%), Gaps = 33/300 (11%)
Query: 1068 DEERKENKRPQRAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPD 1127
D++ +E R +R RR ++ RL + +L + + E + V DE
Sbjct: 31 DDDEEEAARERR----RRARQERLRQKQEEESLGQVTDQVEVNAQNS------VPDEEAK 80
Query: 1128 ESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKT-------------PKKKYSDD 1174
+ + D + F R RR R R L R+ P ++ +D
Sbjct: 81 TTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQND 140
Query: 1175 DEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQI--NYKEDSESDGSQKSLRR 1232
E E+ E SES + + + ET + ++N R N KED E + ++ +
Sbjct: 141 TAENETTEKEEKSESR-QERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPK 199
Query: 1233 GKEIRRVHKRRL---SSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEE 1289
I + ++ES+E + + ++ +++ E + +R + +DE S ++ EE
Sbjct: 200 RGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEE 259
Query: 1290 EEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEE 1349
E++ + +R R+E +E E + ++ D + R+ E+ + ++ R E++E E
Sbjct: 260 EDKERAEAERA-RLEAEERE---RIKAEQDKKIADERARIEAEEKAAAQERERREAEERE 315
Score = 66.2 bits (160), Expect = 2e-10
Identities = 131/677 (19%), Positives = 267/677 (39%), Gaps = 70/677 (10%)
Query: 502 LEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTES 561
LE E +++ D ++A+ E + E SL +++++ ++ E+
Sbjct: 20 LEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEA 79
Query: 562 CTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPG 621
K + + + D LE L + E+ ++ L + +R + ++L
Sbjct: 80 ---KTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLP--- 133
Query: 622 SPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMD 681
S + + + EK S +E E + T TV +S +K D +E+ + K + +
Sbjct: 134 SRRMQNDTAENETTEKEEKSESRQERYEIEETETVT-KSYQKNDWRDAEENKKEDKEKEE 192
Query: 682 NLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISS 741
EE +GS+ +++ + +V E+ T + E T + S + + ISS
Sbjct: 193 E---------EEEKPKRGSIGENQVEV-MVEEKTTESQEETVVMSLKNGQ-------ISS 235
Query: 742 RKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRG 801
+ K + + E + +EE+K R R K + + ++ R
Sbjct: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARI 295
Query: 802 EGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDE 861
E E++ + ++ +++E +++ EK + ++K + K + R R K +E
Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEK---RAAEERQRIK----EE 348
Query: 862 SEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACL 921
+ + E+ EE+ E + A+++E K + +L + + T
Sbjct: 349 EKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLE---EKKHAMQETKIK 405
Query: 922 RPPLMIIPDGEWF--CPPCQHKLLCEKLEEQLQDLDVALK-KKERAERRKERLVYVGISI 978
+ +G+W + KL L++Q ++ ++ K+E+ + K I
Sbjct: 406 GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKD 465
Query: 979 ENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDI 1038
E I +EP +++ + D KK + + + + + F A D
Sbjct: 466 EKIKKDKEP---KEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA-SVDT 521
Query: 1039 KEADGG-GVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDSD 1097
KEA+G V GK + + RG+ S EE ++ K+ Q+ AA ++ ++ + +
Sbjct: 522 KEAEGAPQVEAGKRLEELRRRRGETES----EEFEKLKQKQQEAALELEELKKKRE-ERR 576
Query: 1098 SNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMR 1157
L+EEE + Q+E +D E EE RRL+ R
Sbjct: 577 KVLEEEEQRRK-------QEE---ADRKLREEEE-------------KRRLKEEIERRRA 613
Query: 1158 QSRRLRRKTPKKKYSDD 1174
++ R+K P+ SDD
Sbjct: 614 EAAEKRQKMPEDGLSDD 630
Score = 65.5 bits (158), Expect = 4e-10
Identities = 159/810 (19%), Positives = 311/810 (38%), Gaps = 114/810 (14%)
Query: 680 MDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEG------- 732
MD+ + + ++ E + ++ ++ EEE ER ++
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLG 60
Query: 733 -IKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEI 791
+ + ++++ PD K + E ++E + R RR R +
Sbjct: 61 QVTDQVEVNAQNSVPDEEAKTTTTNTQ---VEGDDEAAFLERLARREERRQK-------- 109
Query: 792 RDQKADKKRGEGEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTR 851
R Q+A +++ E + + + S +L + +E +T K K + + + R+ T
Sbjct: 110 RLQEALERQKEFDPTITDASLSLPSRRMQN--DTAENETTEKEEKSESRQE-RYEIEETE 166
Query: 852 GRWK-YSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCD 910
K Y ND + ++K EEEEE++ + + + N E+++
Sbjct: 167 TVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGE-----------NQVEVMVEEK 215
Query: 911 SCDSGYHTACLRPPLMIIPDGEWFCP-PCQHKLLCEKLEEQLQDLDVALKKKERAERRKE 969
+ +S T +M + +G+ P Q + + +E + + KERAE +
Sbjct: 216 TTESQEETV-----VMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERA 270
Query: 970 RLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEA 1029
RL E I Q+ + D+ + + +K+ A ERR R+ + +E A
Sbjct: 271 RLE--AEERERIKAEQDKKIA-DERARIEAEEKAAAQERERREAEERERMR---EEEKRA 324
Query: 1030 IDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKK-- 1087
+E IKE + + I ++ I +EE++ + QRA A +K
Sbjct: 325 AEE--RQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAK 382
Query: 1088 ---RRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDP-------PSND 1137
++R L+ + +E K+ + ++V N +++ED +
Sbjct: 383 VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWV----NEKKAQEDKLQTAVLKKQGE 438
Query: 1138 DSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSD 1197
+ T ++R + +P + ++ + KK D E +E ++ D + F++ S
Sbjct: 439 EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKK----DKEPKEEVKSFMDRKKGFTEVKSQ 494
Query: 1198 D-------FVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESE 1250
+ T SR + ++ KE ++G+ + + GK + + +RR +ESE
Sbjct: 495 NGEFMTHKLKHTENTFSRPGGRASVDTKE---AEGAPQ-VEAGKRLEELRRRR-GETESE 549
Query: 1251 ESYLSKNSED------DELAK--ESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHR 1302
E K + +EL K E +R V + + EAD + EEE K R+
Sbjct: 550 EFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEK--RRLKEE 607
Query: 1303 IETDEEESCDNAH-------GDANQPARDSQPR--VLPSEQ------ESTKKPYRIESDE 1347
IE E+ + D +P + P+ L E+ +S +K ++S
Sbjct: 608 IERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTH 667
Query: 1348 EEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTE-----KSQTPKDN--STA 1400
+ V K+ S L+ + T P K + + P E KS K N S+
Sbjct: 668 QAAI--VSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSP 725
Query: 1401 SASLASNGTSGGQEAGAPEEEEDELLRVTD 1430
+A+ N + G + G + L + D
Sbjct: 726 TAAGTPNKETAGLKVGVSSRINEWLTKTPD 755
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 74.7 bits (182), Expect = 6e-13
Identities = 121/562 (21%), Positives = 229/562 (40%), Gaps = 82/562 (14%)
Query: 357 IKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKL--SDDFDSPVKGPLCKSVTPTKEFL 414
I S E + E+T+K + D+ PL+K+EI ++ + P + K KE
Sbjct: 114 ISSEDEEDDDGDEDTDKGEIDEP---PLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKG 170
Query: 415 KDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSP 474
K++++++E+ K+ + + E +++ P KT E K +T E+S
Sbjct: 171 KEKVREKEKPEKKAT-------------HKEKIEKKEKPETKTLAKEQKKAKTAEKSEEK 217
Query: 475 SKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQ------ 528
+K +G E + T+ K E++K + ++ D + + H QK Q
Sbjct: 218 TKKE---VKGGKQEKVKQ--TAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRY 272
Query: 529 ---------IEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEK-SPKTKKDKR 578
++ P + L + + ++ + AL E K E+K + +TKK ++
Sbjct: 273 MIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEK 332
Query: 579 PPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHC 638
I K + K+T +D + ++ P E+++ AA+ + +
Sbjct: 333 EDI-----KKKSEKETAID--------VEKKEPGKASETKQGTVKIAAQAAAKKD----- 374
Query: 639 EKLASEKEVVECQSTSTVGG--QSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSE 696
EK K+ + G Q K+ +E K + V D A+T E E
Sbjct: 375 EKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKT---ERAKE 431
Query: 697 TKGSMQKSKFKYKLVP---EEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVL 753
G++ K VP EE+TT + EI E+ + + K K + P L
Sbjct: 432 EIGAVSIKK----AVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASL 487
Query: 754 EPENKQEKTEKEEEKTNVGRTLRRSP------RISRPTAKVA-EIRDQKADKKRGEGEDE 806
+ K+ +T+K+E+ + G+ ++ P + +P ++ E + ++K + +D
Sbjct: 488 K--EKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDI 545
Query: 807 VEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKV----RWTGSRTRGRWKYSSNDES 862
V+ E T ++++LK+ + T K +K KP K R S + K + S
Sbjct: 546 VKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTS 605
Query: 863 EGSGSEKSSAASEEEEEKESEE 884
E + S K E+E KE +
Sbjct: 606 EVTESGKKKTEISEKESKEKAD 627
Score = 69.7 bits (169), Expect = 2e-11
Identities = 134/624 (21%), Positives = 246/624 (39%), Gaps = 99/624 (15%)
Query: 222 NSSRESPSLEDEETKKEE--ETPKQEEQKESEKMKSEEQP-MDLENRSTANVLEE--TTV 276
+S E DE+T K E E P ++++ +K + +E+P ++ + T E+ V
Sbjct: 115 SSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKV 174
Query: 277 KKEKEDEKELVKLPVIVKLEKP-------------LPENEEKKIIKEESDSFKENVKPIK 323
+++++ EK+ I K EKP E E+K KE +E VK
Sbjct: 175 REKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTA 234
Query: 324 VEVKECRADPKDTKSSMEK---PVAQEPERIEFG-----------GNIKSSHEITEKSTE 369
+VKE + P K +K V++ ++ ++ G++K
Sbjct: 235 AKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPL 294
Query: 370 ETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRIS 429
TE+ A L+++E K K + TK+ K++IK++ E
Sbjct: 295 PTEQASRPTPASPALEEKE--------GEKKKAEKKVTSETKKKEKEDIKKKSE------ 340
Query: 430 TITALGHEGKQLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNI-ITEGNGTE 488
TA+ E K+ G+ S+ + K E KE+S K + +G E
Sbjct: 341 KETAIDVEKKE--PGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQE 398
Query: 489 SLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEME---TSLDSSE 545
+ K+ + E + P K + + I++ P + E T E
Sbjct: 399 KKEKHVEPAKSPKKE-HSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQE 457
Query: 546 MAKDLSSKTALSSTESCTMKG-EEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLS 604
+ K+ S KT+ + +KG EEK P + K+K P E K + K + +
Sbjct: 458 IRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEP---------ETKKDEKMSKAGKEVK 508
Query: 605 PIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKV 664
P P ++ E +P + A+ + + H ++++V+ + T + G K
Sbjct: 509 PKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIH------KQDIVKPEKTVSHG-----KP 557
Query: 665 DLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENT-E 723
+ + LK+ T IE+ ++ K + +K++ + + P +T + T +
Sbjct: 558 EEKVLKQVKAVT--------------IEKTAKPKPT-KKAEHREREPPSIKTDKPKPTPK 602
Query: 724 ITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISR 783
TSE + G K T IS ++ K + K L ++EK +E L + +
Sbjct: 603 GTSEVTESGKKKT-EISEKESKEKADMKHL----REEKVSTRKESLQ----LHNVTKAEK 653
Query: 784 PTAKVAEIRDQKADKKRGEGEDEV 807
P ++ D A KK EG ++V
Sbjct: 654 PARVSKDVEDVPASKKAKEGTEDV 677
Score = 64.3 bits (155), Expect = 8e-10
Identities = 107/448 (23%), Positives = 185/448 (41%), Gaps = 87/448 (19%)
Query: 217 SSQQDNSSRESPSLEDEETKKEEETPK-----QEEQKESEKMKSE-EQPMDLENRS---- 266
+ Q + SP+LE++E +K++ K ++++KE K KSE E +D+E +
Sbjct: 296 TEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKA 355
Query: 267 ------TANVLEETTVKK-EKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENV 319
T + + KK EK+++ + K P ++E+P + +EKK +++V
Sbjct: 356 SETKQGTVKIAAQAAAKKDEKKEDSKKTKKP--AEVEQPKGKKQEKK---------EKHV 404
Query: 320 KPIKVEVKECRADPKDTKSSMEKPVAQEPERI-EFGGNIKSSHEITEKSTEETEKLKNDQ 378
+P K KE + P D K V + ER E G + + K E+T K +
Sbjct: 405 EPAKSPKKE-HSVPSD------KQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQE 457
Query: 379 QAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEG 438
K K L D P+KG +E + +K++E K+ ++ G E
Sbjct: 458 IRKEKSGKTSSILKD--KEPIKG--------KEEKVPASLKEKEPETKKDEKMSKAGKEV 507
Query: 439 K---QLVNGEVSDERVAPNFKTE---PIETKFYETKEESYSPSKDRNIITEGNGTESLNS 492
K + G+ +E+ P K E I K K++ P K ++ G E
Sbjct: 508 KPKPPQLQGK-KEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEK---TVSHGKPEE---K 560
Query: 493 VITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETS------LDSSEM 546
V+ +K +EK P ++KA+ E +PP ++T +SE+
Sbjct: 561 VLKQVKAVTIEKTAKPK-------------PTKKAEHREREPPSIKTDKPKPTPKGTSEV 607
Query: 547 AKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPI 606
+ KT +S ES ++ K + + E L+ T +K A R+S
Sbjct: 608 TESGKKKTEISEKES------KEKADMKHLREEKVSTRKESLQLHNVTKAEKPA-RVSKD 660
Query: 607 PEEVPKSTLESEKPGSPEAAETSPPSNI 634
E+VP S + K G+ + + T S I
Sbjct: 661 VEDVPAS--KKAKEGTEDVSPTKQKSPI 686
Score = 61.6 bits (148), Expect = 5e-09
Identities = 103/484 (21%), Positives = 199/484 (41%), Gaps = 86/484 (17%)
Query: 220 QDNSSRESPSLEDEETKKEEETPKQEEQKES-----EKMKSEEQPMDLENRSTANVLEET 274
++ ++ +E+TKKE + KQE+ K++ E K+ +P + E++ A V
Sbjct: 203 KEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAV---- 258
Query: 275 TVKKEKEDEKELVKLPVIV------------KLEKPLPENEEKK------IIKEESDSFK 316
K E++D+ + + + + PLP + + ++E+ K
Sbjct: 259 -SKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKK 317
Query: 317 ENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFG-------GNIKSSHEITEKSTE 369
+ K + E K + + +D K EK A + E+ E G G +K + + K E
Sbjct: 318 KAEKKVTSETK--KKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDE 375
Query: 370 ETE---KLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCK 426
+ E K K + + P K++ K + P K P + P+ + +K + ++ +E
Sbjct: 376 KKEDSKKTKKPAEVEQPKGKKQEK-KEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIG 434
Query: 427 RISTITALGHEGKQLVNGEVSDE-RVAPNFKT-------EPIETKFYET----KEESYSP 474
+S A+ + ++ V E R + KT EPI+ K + KE+
Sbjct: 435 AVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPET 494
Query: 475 SKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDP 534
KD + G + + K EK ++K+A +I S+K QI + D
Sbjct: 495 KKDEKMSKAGKEVKPKPPQLQGKKE---EKPEPQIKKEAKPAI------SEKVQIHKQDI 545
Query: 535 PEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKK----DKRPPILECLEKLEK 590
+ E ++ + + L ++ T++ K TKK ++ PP + K +K
Sbjct: 546 VKPEKTVSHGK-----PEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSI----KTDK 596
Query: 591 SKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVEC 650
K T + S + E K T SEK E+ E + ++ + EK+++ KE ++
Sbjct: 597 PKPT-----PKGTSEVTESGKKKTEISEK----ESKEKADMKHLRE--EKVSTRKESLQL 645
Query: 651 QSTS 654
+ +
Sbjct: 646 HNVT 649
Score = 58.9 bits (141), Expect = 3e-08
Identities = 100/520 (19%), Positives = 205/520 (39%), Gaps = 82/520 (15%)
Query: 676 TKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEI-TSERQKEGIK 734
TKV + + E+ K + K K + K PE +T A E + T+E+ +E K
Sbjct: 160 TKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTK 219
Query: 735 LTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLR------------------ 776
++ ++K + KV E + K +++E+K +
Sbjct: 220 KEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVH 279
Query: 777 ------RSPRI---------SRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKE 821
+SP I SRPT + +++ +KK+ E ++ ++ +K +K++
Sbjct: 280 GDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAE-----KKVTSETKKKEKED 334
Query: 822 ILKKSEKDTNSKVSKVKPKGKVRWTGSRT-RGRWKYSSNDESEGSGSEKSSAASEEEEEK 880
I KKSEK+T V K +P GK T T + + ++ + + S+K+ +E E+ K
Sbjct: 335 IKKKSEKETAIDVEKKEP-GKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPK 393
Query: 881 ----ESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCP 936
E +E + P K+ +P+ ++ + ++ + + E
Sbjct: 394 GKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKE-EKTTK 452
Query: 937 PCQHKLLCEK-------------LEEQLQDLDVALKKKERAERRKERLVYVGISIENIIP 983
+ ++ EK ++ + + + +LK+KE ++ E++ G ++
Sbjct: 453 TVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVK---- 508
Query: 984 PQEPDFSEDQEEK-----KKDSK---KSKANLLERRSTRTRKCISYRFDEFDEAIDEAIE 1035
P+ P +EEK KK++K K + ++ + K +S+ E E +
Sbjct: 509 PKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPE------EKVL 562
Query: 1036 DDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLD 1095
+K + K HR ++ +I ++ K + KK+ +++ +
Sbjct: 563 KQVKAVTIEKTAKPKPTKK-AEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKE 621
Query: 1096 SDSNLDEEESEDEFKIS---DGSQDEFVVSDENPDESEED 1132
S D + +E K+S + Q V E P +D
Sbjct: 622 SKEKADMKHLREE-KVSTRKESLQLHNVTKAEKPARVSKD 660
Score = 50.4 bits (119), Expect = 1e-05
Identities = 120/632 (18%), Positives = 238/632 (37%), Gaps = 115/632 (18%)
Query: 743 KKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGE 802
K + D PP + + E ++KTEK+E +P K I+ + K++ +
Sbjct: 130 KGEIDEPP-LRKKEIHKDKTEKQE----------------KPERK---IQTKVTHKEKEK 169
Query: 803 GEDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDES 862
G+++V E+ +K KE ++K EK ++K + K K T + + + E
Sbjct: 170 GKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAK-------TAEKSEEKTKKEV 222
Query: 863 EGSGSEK--SSAASEEE--------EEKESEEAILADDDEPCKKCGLPNHPELILLCDSC 912
+G EK +AA +E +EKE +E E + + I +
Sbjct: 223 KGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDL 282
Query: 913 DSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQ---DLDVALKKKERAERRKE 969
G A + PPL P + P L EK E+ + + KKKE+ + +K+
Sbjct: 283 KPGQSPA-IPPPL---PTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKK 338
Query: 970 RLVYVGISIENIIPPQEPDFSED-----------QEEKKKDSKKSKANLLERRSTRTRKC 1018
I +E P + + + ++EKK+DSKK+K E + +K
Sbjct: 339 SEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTK-KPAEVEQPKGKK- 396
Query: 1019 ISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQ 1078
E ++ +E V K + T ++I + ++ K+ +
Sbjct: 397 --------QEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEE 448
Query: 1079 RAAAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDD 1138
+ ++ R+ + S L ++E G +++ S E++P + D
Sbjct: 449 KTTKTVEQEIRKEKSGKTSSILKDKEP------IKGKEEKVPAS-----LKEKEPETKKD 497
Query: 1139 SDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKK--------------YSDDDEEEESEENS 1184
+ ++ P P Q ++ + P+ K D + E++ +
Sbjct: 498 EKMSKAGKEVK--PKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHG 555
Query: 1185 RDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRL 1244
+ E + +T + + + + + ++D + + + E+ K++
Sbjct: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
Query: 1245 SSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIE 1304
SE E SK D + +E K S RK ++A+ KP+ R+
Sbjct: 616 EISEKE----SKEKADMKHLREEKVSTRKESLQLHNVTKAE--------KPA-----RVS 658
Query: 1305 TDEEESCDNAHGDANQPARDSQPRVLPSEQES 1336
D E+ A++ A++ V P++Q+S
Sbjct: 659 KDVEDV------PASKKAKEGTEDVSPTKQKS 684
Score = 43.1 bits (100), Expect = 0.002
Identities = 42/196 (21%), Positives = 83/196 (42%), Gaps = 22/196 (11%)
Query: 1173 DDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRR 1232
DDD +E++++ D + D E + + R+ Q + + +KE + G +K +
Sbjct: 121 DDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTK-VTHKEKEK--GKEKVREK 177
Query: 1233 GK-EIRRVHKRRLSSSESEESY-LSKNSEDDELAKESKRSVRK--RGRSTDEYSEADEEE 1288
K E + HK ++ E E+ L+K + + A++S+ +K +G ++ + +
Sbjct: 178 EKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKV 237
Query: 1289 EEEEGKPSRKR----LHRIETDEEESCDN-----------AHGDANQPARDSQPRVLPSE 1333
+E + PS+ + + + E D HGD + P LP+E
Sbjct: 238 KEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTE 297
Query: 1334 QESTKKPYRIESDEEE 1349
Q S P +E+E
Sbjct: 298 QASRPTPASPALEEKE 313
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 73.9 bits (180), Expect = 1e-12
Identities = 168/802 (20%), Positives = 318/802 (39%), Gaps = 121/802 (15%)
Query: 166 QLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAE--TLALLKAQIDPVLLKNSSQQDNS 223
+++++ +++M +++ +Q+ + I + +++A + ++L ++ V+ + Q +
Sbjct: 560 RVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQT 619
Query: 224 SRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDE 283
S D T KEEE ++ Q + +K+E Q + ++ AN + EK +
Sbjct: 620 EDSLASERDRLTSKEEEL--KDIQNMNFLLKAEVQKL----QALANEQAAAAHELEKMQQ 673
Query: 284 KELVKLPVIVKLEKPLPEN-----EEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKS 338
VK I LE+ L EE KI+ +++ + K V+ ++ V E KD
Sbjct: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE--QPNKDVVE 731
Query: 339 SMEKPVAQEPERIEFGGNIKSSHEI-------------TEKS--TEETEKLK---NDQQA 380
MEK + ++ E+++ + + I TE S T+E + LK NDQ +
Sbjct: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
Query: 381 KIPLKKREIKLSDDFDSPVKG-------PLCKSVTPTK--EFLKDEIKQEEETCKRIS-- 429
L + K+ + D +K L K K + LK EIK +E +
Sbjct: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE 851
Query: 430 -----TITALGHEGKQLVNGEVSDERVAPNFKTEPIETK----------FYETKEESYSP 474
+IT+ E + L+ G+ +E++ N +E K + +EE+ S
Sbjct: 852 KAQQLSITSKVQELQNLLKGK--EEQM--NTMKAVLEEKEKDLANTGKWLQDLQEENESL 907
Query: 475 SKDRNIITEGNGTESLNS-------VITSMKTGELEKETAPLRK---DADSSISVLE--- 521
+ + N E+ ++ ++ K EL++ A L++ D S +L+
Sbjct: 908 KAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ 967
Query: 522 -----IHSQKAQIEEPD-------PPEMETSLDSSEMAKDLSSK-TALSSTESCTMKGEE 568
SQ Q+++ + PP E SE K++S L S + E
Sbjct: 968 DENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAV----E 1023
Query: 569 KSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAET 628
K D R E +E L ++K DK + ++V LE+++ +
Sbjct: 1024 HQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKV 1083
Query: 629 SPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMD----NLD 684
S PSN+ EK+ EC + T G + VK ++ + + D T ++++
Sbjct: 1084 SVPSNLSYGEWLHGFEKKAKECMA-GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV 1142
Query: 685 NAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKK 744
A+T GI + + +++K+K K+ +T + TS Q+ R+ S K
Sbjct: 1143 LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE-----LERLRSENK 1197
Query: 745 KPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRD--QKADKKRGE 802
+ ++E E E EK + R S +V E++D + KK +
Sbjct: 1198 ------DIENLRREREHLEMELEKAEMER--------STYVTEVRELKDLLTELQKKLDD 1243
Query: 803 GEDEV--EEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSND 860
E + E L K E L K + N + K + + + + ++ D
Sbjct: 1244 SYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGD 1303
Query: 861 ESEGSGSEKSSAASEEEEEKES 882
+ S+ S E+E S
Sbjct: 1304 TTVIENSDVSPETESSEKETMS 1325
Score = 34.7 bits (78), Expect = 0.68
Identities = 56/279 (20%), Positives = 104/279 (37%), Gaps = 42/279 (15%)
Query: 1065 TILDEERKENKRPQRAAAAR------RKKRRRLNDLDSDSNLDEEESED---EFKISDGS 1115
T+ DE + KR Q+ + KK+ + ++ + NL E +SE +FK+SD
Sbjct: 32 TLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQN-GNLHESDSESVPRDFKLSDA- 89
Query: 1116 QDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRR----KTPKKKY 1171
V D D+ P + ++ + R+ + +P+ + + ++ K P KK
Sbjct: 90 ---LAVED---DQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKV 143
Query: 1172 ---------SDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSE 1222
+ E S++ +S D D VET S+R + ++ + E
Sbjct: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQE 203
Query: 1223 SDGSQKSLRRGKE-----------IRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSV 1271
S +K K+ I L + + K D L + +
Sbjct: 204 SGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGI 263
Query: 1272 RKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEES 1310
+K G + +E D+E E + K L + E+E+
Sbjct: 264 QKSGTKKLK-TETDKENAEVKFKDFLLSLKTMMFSEDEA 301
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 73.9 bits (180), Expect = 1e-12
Identities = 168/802 (20%), Positives = 318/802 (39%), Gaps = 121/802 (15%)
Query: 166 QLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAE--TLALLKAQIDPVLLKNSSQQDNS 223
+++++ +++M +++ +Q+ + I + +++A + ++L ++ V+ + Q +
Sbjct: 560 RVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQT 619
Query: 224 SRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDE 283
S D T KEEE ++ Q + +K+E Q + ++ AN + EK +
Sbjct: 620 EDSLASERDRLTSKEEEL--KDIQNMNFLLKAEVQKL----QALANEQAAAAHELEKMQQ 673
Query: 284 KELVKLPVIVKLEKPLPEN-----EEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKS 338
VK I LE+ L EE KI+ +++ + K V+ ++ V E KD
Sbjct: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE--QPNKDVVE 731
Query: 339 SMEKPVAQEPERIEFGGNIKSSHEI-------------TEKS--TEETEKLK---NDQQA 380
MEK + ++ E+++ + + I TE S T+E + LK NDQ +
Sbjct: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVS 791
Query: 381 KIPLKKREIKLSDDFDSPVKG-------PLCKSVTPTK--EFLKDEIKQEEETCKRIS-- 429
L + K+ + D +K L K K + LK EIK +E +
Sbjct: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE 851
Query: 430 -----TITALGHEGKQLVNGEVSDERVAPNFKTEPIETK----------FYETKEESYSP 474
+IT+ E + L+ G+ +E++ N +E K + +EE+ S
Sbjct: 852 KAQQLSITSKVQELQNLLKGK--EEQM--NTMKAVLEEKEKDLANTGKWLQDLQEENESL 907
Query: 475 SKDRNIITEGNGTESLNS-------VITSMKTGELEKETAPLRK---DADSSISVLE--- 521
+ + N E+ ++ ++ K EL++ A L++ D S +L+
Sbjct: 908 KAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ 967
Query: 522 -----IHSQKAQIEEPD-------PPEMETSLDSSEMAKDLSSK-TALSSTESCTMKGEE 568
SQ Q+++ + PP E SE K++S L S + E
Sbjct: 968 DENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAV----E 1023
Query: 569 KSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAET 628
K D R E +E L ++K DK + ++V LE+++ +
Sbjct: 1024 HQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKV 1083
Query: 629 SPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMD----NLD 684
S PSN+ EK+ EC + T G + VK ++ + + D T ++++
Sbjct: 1084 SVPSNLSYGEWLHGFEKKAKECMA-GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSV 1142
Query: 685 NAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKK 744
A+T GI + + +++K+K K+ +T + TS Q+ R+ S K
Sbjct: 1143 LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE-----LERLRSENK 1197
Query: 745 KPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRD--QKADKKRGE 802
+ ++E E E EK + R S +V E++D + KK +
Sbjct: 1198 ------DIENLRREREHLEMELEKAEMER--------STYVTEVRELKDLLTELQKKLDD 1243
Query: 803 GEDEV--EEESTALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSND 860
E + E L K E L K + N + K + + + + ++ D
Sbjct: 1244 SYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGD 1303
Query: 861 ESEGSGSEKSSAASEEEEEKES 882
+ S+ S E+E S
Sbjct: 1304 TTVIENSDVSPETESSEKETMS 1325
Score = 34.7 bits (78), Expect = 0.68
Identities = 56/279 (20%), Positives = 104/279 (37%), Gaps = 42/279 (15%)
Query: 1065 TILDEERKENKRPQRAAAAR------RKKRRRLNDLDSDSNLDEEESED---EFKISDGS 1115
T+ DE + KR Q+ + KK+ + ++ + NL E +SE +FK+SD
Sbjct: 32 TLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQN-GNLHESDSESVPRDFKLSDA- 89
Query: 1116 QDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRR----KTPKKKY 1171
V D D+ P + ++ + R+ + +P+ + + ++ K P KK
Sbjct: 90 ---LAVED---DQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKV 143
Query: 1172 ---------SDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSE 1222
+ E S++ +S D D VET S+R + ++ + E
Sbjct: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQE 203
Query: 1223 SDGSQKSLRRGKE-----------IRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSV 1271
S +K K+ I L + + K D L + +
Sbjct: 204 SGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGI 263
Query: 1272 RKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEES 1310
+K G + +E D+E E + K L + E+E+
Sbjct: 264 QKSGTKKLK-TETDKENAEVKFKDFLLSLKTMMFSEDEA 301
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 73.9 bits (180), Expect = 1e-12
Identities = 147/748 (19%), Positives = 289/748 (38%), Gaps = 134/748 (17%)
Query: 167 LDQDHNVRMYIEE---QDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNS 223
++++H +R IE+ + + D C+++ E LLK +++ L+ + +
Sbjct: 2293 IEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVEN--LERELEIART 2350
Query: 224 SRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDE 283
++E +LE E +K E ET K + + ++ ++ E + N+ E ++E+ E
Sbjct: 2351 NQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISE 2410
Query: 284 KELVKLPVIVKLEKPLPENEEKKIIKEESDS------------FKENVKPIKVEVKECRA 331
E++ E L E E++K+ +E S E V + + + C+A
Sbjct: 2411 LEIINS----SFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA 2466
Query: 332 DPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKL 391
++ S +E ++ + ++ K+++ + + S + D + K+ K EI
Sbjct: 2467 KEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR 2526
Query: 392 SDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERV 451
LK++I+ +E+ ++S + H+ + N E+ + V
Sbjct: 2527 ----------------------LKNQIQDQEQLVSKLSQVEG-EHQLWKEQNLELRNLTV 2563
Query: 452 APNFKTEPIETK------FYETKEESYSPSKDRNIITEGNG---TESLNSVIT------- 495
K + +++K E + SY ++ +T+ + E +N +
Sbjct: 2564 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQR 2623
Query: 496 -----SMKTGELEKETAPLRKDADSSISVL--EIHSQKAQIEEP--DPPEMETSLDSSEM 546
+ KT EL++E + + + +L EI S K Q++E + E++ SLD M
Sbjct: 2624 EMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDC--M 2681
Query: 547 AKDLSSKTALSSTESC-------------------TMKGEEKSPKTKKDKRPPILECL-- 585
KD K E T K E +T ++K ECL
Sbjct: 2682 HKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSS 2741
Query: 586 EKLE----KSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSN----IIDH 637
+KLE KS K L+ + + I EE+ K+ +++ K + E +I
Sbjct: 2742 QKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKS 2801
Query: 638 CEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSET 697
C++L EKE+++ + + Q +K T MD + T+ I+E ET
Sbjct: 2802 CKQLEEEKEILQKELSQLQAAQEKQK------------TGTVMDTKVDELTTEIKELKET 2849
Query: 698 KGSMQKSKFKY------------KLVPEEETTASENTEITSERQKEGIKLTIRISSRKKK 745
K +Y KL +E ++ + S++ K+ + + +
Sbjct: 2850 LEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPG 2909
Query: 746 PDSPPKVLE---PENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGE 802
P P V E + + + K + + + R PT E +K+ K
Sbjct: 2910 PSPIPSVTEKRLSSGQNKASGKRQRSSGIWENGR------GPTPATPESFSKKSKKAVMS 2963
Query: 803 GEDEVEE-ESTALQKTDKKEILKKSEKD 829
G E+ E T + E++KK D
Sbjct: 2964 GIHPAEDTEGTEFEPEGLPEVVKKGFAD 2991
Score = 53.1 bits (126), Expect = 2e-06
Identities = 156/931 (16%), Positives = 375/931 (40%), Gaps = 124/931 (13%)
Query: 134 NLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQDDQDGSSWKCIVR 193
N + +N INE + +RLQ ++ G Q+++ +++ +E+ + K + +
Sbjct: 287 NQELRNKINELE---LRLQGHEKEMKG-----QVNKFQELQLQLEKAKVELIEKEKVLNK 338
Query: 194 NRNELAETLA----------LLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPK 243
R+EL T A L+ ++ + S Q+ N+ SLE + +KE+E +
Sbjct: 339 CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE 398
Query: 244 Q--EEQKESEKMKSE------------EQPMDLENRSTANVLEETTVKKEKEDEKELVKL 289
+ +Q+ + + E +Q ++ N A + + T+VK++ E+ E K
Sbjct: 399 ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458
Query: 290 PVIVKLE----KPLPENEEKKI---IKEESDSFKENVKPIKVEVKECRADPKDTKSSMEK 342
+ + + ENE ++ +K+E++ K + + EV A+ K+ K +
Sbjct: 459 KLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLN- 517
Query: 343 PVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSD-DFDSPVKG 401
+ F +K+ + E + ++ N Q+ + L+K ++ ++D +
Sbjct: 518 ------QSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQ 571
Query: 402 PLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIE 461
L K E L D++ + E+ K + ++AL E K+ E+ +E+ + E
Sbjct: 572 DLLKKREHHIEQLNDKLSKTEKESKAL--LSAL--ELKKKEYEELKEEKTLFSCWKSENE 627
Query: 462 TKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLE 521
+ + E + N + T+ + S + + LE + L + + +VL+
Sbjct: 628 KLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLD 687
Query: 522 IHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTK------K 575
S + + ++ E++ + S+ + T T + E+ K +
Sbjct: 688 SKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM 747
Query: 576 DKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNII 635
DK + + E + KDA ++ E+ +S L ++ + A +NII
Sbjct: 748 DKDRCYQDLHAEYESLRDLLKSKDASLVT--NEDHQRSLLAFDQ----QPAMHHSFANII 801
Query: 636 DHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPS 695
+ SE+ ++ + ++ L+ + EF+ +++ EE
Sbjct: 802 GEQGSMPSERSECRLEADQSPKNSAI----LQNRVDSLEFSLESQKQMNSDLQKQCEELV 857
Query: 696 ETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEP 755
+ KG ++++ K + + ++ +E ++ S+ Q++ ++ ++ K L+
Sbjct: 858 QIKGEIEENLMKAEQM--HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQL 915
Query: 756 ENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQ 815
N + +TE+ E + L++S + + K ++ + ++ +E +++
Sbjct: 916 LNDKVETEQAEI-----QELKKSNHLLEDSLKELQLLSETLSLEK--------KEMSSII 962
Query: 816 KTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASE 875
+K+EI + +++ N + ++ +S ++ + + +KS + +
Sbjct: 963 SLNKREIEELTQE--NGTLKEIN------------------ASLNQEKMNLIQKSESFAN 1002
Query: 876 EEEEKESEEAILADDDEPCKKCGLPNHPELILL--CDSCDSGYHTACLRPPLMIIPDGEW 933
+E+E + L+D + +LILL C+ + Y + + +
Sbjct: 1003 YIDEREKSISELSDQYK---------QEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKL 1053
Query: 934 FCPPCQHKLLCEKLEEQLQDLDVALKKKER--------AERRKERLVYVGISIENIIPPQ 985
C + LCE + +L+ L A K+ + AE R + L+ + +E +
Sbjct: 1054 ECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLM---LELETVQQAL 1110
Query: 986 EPDFSEDQEEKKKDSKKSKANLLERRSTRTR 1016
+ +++Q K ++ K ++ + + +
Sbjct: 1111 RSEMTDNQNNSKSEAGGLKQEIMTLKEEQNK 1141
Score = 49.7 bits (117), Expect = 2e-05
Identities = 123/695 (17%), Positives = 272/695 (39%), Gaps = 95/695 (13%)
Query: 225 RESPSLEDEETKKEEETPKQEEQKE-----SEKMKSEEQPMDLENRSTANVL-------- 271
RE+ SL+D+ E E EE +E +E K+E + + + A L
Sbjct: 2147 RENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLV 2206
Query: 272 -----EETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKK--IIKEESDSFKENVKPIKV 324
+E K+ +E + +L +L ++ K L E +E+ IKEES + E ++
Sbjct: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLK 2266
Query: 325 EVKECRAD-------PKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEK-------STEE 370
E+ E A K T+ S++ P+ +E + +++ E EK +E
Sbjct: 2267 ELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKE 2326
Query: 371 TEKLKNDQQAKIPLKKREIKLS------------------DDFDSPVKGPL--------- 403
+E + + ++ +RE++++ + + ++G
Sbjct: 2327 SEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELD 2386
Query: 404 CKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKT----EP 459
++ KE L +E+++E+E RIS + + + ++ E E+V K+ E
Sbjct: 2387 VVTIRSEKENLTNELQKEQE---RISELEIINSSFENILQ-EKEQEKVQMKEKSSTAMEM 2442
Query: 460 IETKFYETKE--------ESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRK 511
++T+ E E + +K++N+ ++ E L E + L+
Sbjct: 2443 LQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLE-LEKAQLLQGLDEAKNNYIVLQS 2501
Query: 512 DADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSP 571
+ I +E QK + ++ + ++ + E L SK + E K +
Sbjct: 2502 SVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQE---QLVSKLSQVEGEHQLWKEQNLEL 2558
Query: 572 KTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLES----EKPGSPEAAE 627
+ + ++ L+ S + L+ + E+ + ++ EK A E
Sbjct: 2559 RNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618
Query: 628 TSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQ 687
T + + +K A +E + + G + ++++ K+ + +E L +
Sbjct: 2619 TELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSL 2678
Query: 688 TSGIEEPSETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPD 747
++ E +G +++ +Y+L E + + + +Q E + I + ++K
Sbjct: 2679 DCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYE-----VEIQTYREKLT 2733
Query: 748 SPPKVLEPENKQ---EKTEKEEEKTNVGRTLRRSPRISRPTA-KVAEIRDQKADKKRGEG 803
S + L + + K+ KEE ++ T + + + + + K + +R +G
Sbjct: 2734 SKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQG 2793
Query: 804 EDEVEEESTALQKTDKKEILKKSEKDTNSKVSKVK 838
+ ++ +S Q ++KEIL+K + K K
Sbjct: 2794 KMKLLIKS-CKQLEEEKEILQKELSQLQAAQEKQK 2827
Score = 45.8 bits (107), Expect = 3e-04
Identities = 151/727 (20%), Positives = 298/727 (40%), Gaps = 121/727 (16%)
Query: 193 RNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDE-ETKKEEETPKQEE----Q 247
RN+N + E + +A + + + Q+NS E+ L+ E T KEE+ Q+E
Sbjct: 1095 RNQNLMLELETVQQA----LRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLL 1150
Query: 248 KESEK----MKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLPV-----------I 292
+E+E+ MK++ + +LE+ N ++E ++ + + K + L V +
Sbjct: 1151 QENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQL 1210
Query: 293 VKLEKPLPENE--------EKKIIKEESDSFKENVKPIKVEVKECR--ADPKDTKSSMEK 342
V+LE L E EK+ ++ E + + +++ ++ + + + KD + E+
Sbjct: 1211 VQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEE 1270
Query: 343 PVAQEPERIEFGGN----IKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSP 398
P + N ++ S + T E EK+ QA +K E+ +
Sbjct: 1271 KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQA----EKYELV------TE 1320
Query: 399 VKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTE 458
+ + +T T+ K EE K ++ + L ++ L++GE+ ++ F +
Sbjct: 1321 LNDSRSECITATR-------KMAEEVGKLLNEVKIL-NDDSGLLHGELVEDIPGGEFGEQ 1372
Query: 459 PIETKFYETKEESYSPSKDRNIITEGNGTE--SLNSVITSMKTGELEKETAPLRKDADSS 516
P E S +P + E N E +L+ M EL+++ L+ +
Sbjct: 1373 P-----NEQHPVSLAP------LDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKI- 1420
Query: 517 ISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKD 576
+H Q Q+ E++T +DS + A++L T L + + +K E ++
Sbjct: 1421 -----LHDQHCQMSS-KMSELQTYVDSLK-AENLVLSTNLRNFQGDLVK--EMQLGLEEG 1471
Query: 577 KRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIID 636
P + S + D R + E+ +L S G+ A + S +D
Sbjct: 1472 LVPSLSSSCVPDSSSLSSLGDSSFYR--ALLEQTGDMSLLSNLEGAVSANQCS-----VD 1524
Query: 637 HCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSE 696
+ ++E + + T + + V+ +LE+L E V +L+ +EE E
Sbjct: 1525 EVFCSSLQEENLTRKETPSAPAKGVE--ELESLCE------VYRQSLEK-----LEEKME 1571
Query: 697 TKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKV-LEP 755
++G M K K + E E ++SERQ+ +S ++ V LE
Sbjct: 1572 SQGIM-----KNKEIQELEQL------LSSERQELDCLRKQYLSENEQWQQKLTSVTLEM 1620
Query: 756 ENKQEKTEKEEEKTNVGRTLRR--SPRISRPTAKVAEIRDQKADKKRGEGED-EVEEEST 812
E+K +K+ E+ ++ + R + + + I + A + R E D E S
Sbjct: 1621 ESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSE 1680
Query: 813 ALQKTDKKEIL----KKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSE 868
++T K ++ K +++D N + K+ G V+ TG + + S + E G +
Sbjct: 1681 TTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECS---GEQSPDTNYEPPGED 1737
Query: 869 KSSAASE 875
K+ +SE
Sbjct: 1738 KTQGSSE 1744
Score = 35.4 bits (80), Expect = 0.40
Identities = 57/265 (21%), Positives = 116/265 (43%), Gaps = 51/265 (19%)
Query: 61 GEVPKELVELHLKL--MRKIGKSVTADRWEKYLIKICQEFNSTWAWEMEKKGYLEMSVEC 118
G+V +E+ E L+L K +++ D ++Y ++I T+ ++ K S +
Sbjct: 2690 GKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEI-----QTYREKLTSKEECLSSQKL 2744
Query: 119 KLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDK-DGLMYWYQLDQDHNVRMYI 177
++ LLK E + +++LK A T L+ + + K D L Y QL
Sbjct: 2745 EIDLLKSSKE-ELNNSLK---------ATTQILEELKKTKMDNLKYVNQL---------- 2784
Query: 178 EEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKK 237
++++++ K ++++ +L E +L+ ++ + Q+ + + TK
Sbjct: 2785 KKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMD--------TKV 2836
Query: 238 EEETPKQEEQKES--EKMKSEEQPMDL--------ENRSTANVLEETTV-----KKEKED 282
+E T + +E KE+ EK K ++ +D E A + ET V ++ K+D
Sbjct: 2837 DELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQD 2896
Query: 283 EKELVKLPVIVKLEKPLPENEEKKI 307
+ L +V P+P EK++
Sbjct: 2897 SRGSPLLGPVVPGPSPIPSVTEKRL 2921
>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 72.8 bits (177), Expect = 2e-12
Identities = 164/754 (21%), Positives = 296/754 (39%), Gaps = 104/754 (13%)
Query: 171 HNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSL 230
H++RM ++ + DQ I+R + + +A L+ + PV R +P +
Sbjct: 732 HHLRM-LDFRSDQF-----VIIRREKLIQDHMAKLQLNLRPV-----DVDPECLRWTPVI 780
Query: 231 EDEETKKEEETPKQEEQKESEKMKSEEQPMDLE-NRSTANVLEETTVKKEKEDEKELVKL 289
EEE + EE E+E+ + +E+ +++ +S ++ +E + ++K V
Sbjct: 781 VSNSVVSEEEEEEAEEG-ENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMA 839
Query: 290 PVI-VKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEP 348
PV +L K + ++ + S + K K + R KD+K +E+ +
Sbjct: 840 PVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQE---RFGDKDSKLLLEETSSAPQ 896
Query: 349 ERIEFGGNIKSSHEITEKSTEETEKL-----KNDQQAKIPLKKREIKLSDDFDSPVKGPL 403
E ++G + S E+ TE E+L + Q K L KR +LS+ + P +G L
Sbjct: 897 E--QYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKR--RLSEGVE-PWRGQL 951
Query: 404 CKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLV------NGEVSDERVAPNFKT 457
KS E LK + + E R + EG + V + E +E +P +
Sbjct: 952 KKS----PEALKCRLTEGSERLPRRYS------EGDRAVLRGFSESSEEEEEPESPRSSS 1001
Query: 458 EPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSI 517
PI TK +++ + + R + + + SV+T + E P +D+DS
Sbjct: 1002 PPILTKPTLKRKKPFLHRRRRVRKRKHHNS----SVVTETISETTEVLDEPF-EDSDSER 1056
Query: 518 SVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDK 577
+ + +I+E + E E L E + LSS+ L S K +++ + D
Sbjct: 1057 PMPRLEPT-FEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDD 1115
Query: 578 RP--PILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNII 635
PIL+ + L K + + P E ST +K G P+ P
Sbjct: 1116 ADDTPILKPVSLLRK----------RDVKNSPLEPDTSTPLKKKKGWPKGKSRKPI---- 1161
Query: 636 DHCEKLASEKEVVEC-QSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEP 694
H +K K + + V Q+ + ++ + K++ ++ EP
Sbjct: 1162 -HWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQ-------ESEETVEP 1213
Query: 695 SETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLE 754
E ++ K EEE +E E +++ + +S +SP E
Sbjct: 1214 KEDMPLPEERK-------EEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSP----E 1262
Query: 755 PENKQEKTEKEEEKTNVGRTLRRSPRISR--PTAKVAEIRDQKADKKRGEGEDEVEEEST 812
E K+ + E+EEEK V R+S + + E D A+ + + D +E+
Sbjct: 1263 TETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDG 1322
Query: 813 ALQKTDKKEI--------------LKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSS 858
L+ T KKE+ +++S D N + S+ K K K + + S
Sbjct: 1323 HLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEE---TELDSEEEQPS 1379
Query: 859 NDESEGSGSEKSSAASEEEEEKESEEAILADDDE 892
+D S S S EE+ EE I ++E
Sbjct: 1380 HDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEE 1413
Score = 52.0 bits (123), Expect = 4e-06
Identities = 83/377 (22%), Positives = 138/377 (36%), Gaps = 65/377 (17%)
Query: 990 SEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRG 1049
SE++EE+ ++ + + ER E + ++ +++ + KE D V
Sbjct: 787 SEEEEEEAEEGENEEPQCQER--------------ELEISVGKSVSHENKEQDSYSVESE 832
Query: 1050 KDISTITGHRGKDIS--TILDEERKENKRPQRAAAARRKKRR---RLNDLDSDSNLDEEE 1104
K + +S + + N +P R RK R+ R D DS L+E
Sbjct: 833 KKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETS 892
Query: 1105 SEDEFKI------SDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQ 1158
S + + S+ +Q+++ S+E SEE P + D D RRL S +
Sbjct: 893 SAPQEQYGECGEKSEATQEQYTESEEQLVASEEQP--SQDGKPDLPKRRL----SEGVEP 946
Query: 1159 SRRLRRKTPKK-KYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINY 1217
R +K+P+ K + E + + FS+ E S R+ I
Sbjct: 947 WRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILT 1006
Query: 1218 KEDSESDGSQKSLRRGKEI----RRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRK 1273
K +L+R K RRV KR+ +S +S+
Sbjct: 1007 KP---------TLKRKKPFLHRRRRVRKRKHHNSSVVTETISE----------------- 1040
Query: 1274 RGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSE 1333
+T+ E E+ + E P + I+ +EEE +N R S VL +
Sbjct: 1041 ---TTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQ 1097
Query: 1334 QESTKKPYRIESDEEED 1350
S +K E DEE D
Sbjct: 1098 SSSKRKSKDEEEDEESD 1114
Score = 50.8 bits (120), Expect = 9e-06
Identities = 146/782 (18%), Positives = 271/782 (34%), Gaps = 126/782 (16%)
Query: 713 EEETTASENTEITSERQKEGIKLTIRISSRKKKPDS-------PPKVLEP--ENKQEKTE 763
EEE EN E + ++ I + +S K+ DS P+V+ P + K
Sbjct: 791 EEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQV 850
Query: 764 KEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGE----------GEDEVEEESTA 813
+ R R R K E K K E GE + E+T
Sbjct: 851 LPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQ 910
Query: 814 LQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDES--EGSGSEKSS 871
Q T+ +E L SE+ + PK ++ RG+ K S GSE+
Sbjct: 911 EQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLP 970
Query: 872 AASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDG 931
E + A+L E ++ P P PP++ P
Sbjct: 971 -----RRYSEGDRAVLRGFSESSEEEEEPESPR---------------SSSPPILTKPTL 1010
Query: 932 EWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSE 991
+ P + K + + V E E E + E +P EP F
Sbjct: 1011 KRKKPFLHRRRRVRKRKHHNSSV-VTETISETTEVLDEP--FEDSDSERPMPRLEPTFEI 1067
Query: 992 DQEEKKKDSKK----------SKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEA 1041
D+EE+++D + S ++L +S+ RK + +E DE D+A DD
Sbjct: 1068 DEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKS---KDEEEDEESDDA--DDTPIL 1122
Query: 1042 DGGGVGRGKDISTITGHRGKDISTILDEER-----------KENKRPQRAA--------- 1081
+ R +D+ D ST L +++ KRP R
Sbjct: 1123 KPVSLLRKRDVKN--SPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIM 1180
Query: 1082 -----------------AARRKKRRRLNDLDS--------DSNLDEEESEDEFKISDGSQ 1116
A R+ K + + + +EEE + E + ++ +
Sbjct: 1181 PVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGE 1240
Query: 1117 DEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDE 1176
+E S E P S D ++ +++T R + R+ + + + + +E
Sbjct: 1241 EEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEE 1300
Query: 1177 EEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEI 1236
EE++ + ++ +DD D +E+ +++ Q + + KE+ S K
Sbjct: 1301 EEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSR 1360
Query: 1237 RRVHKRRLSSSESEESYLSKN-SEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKP 1295
++ + + +SEE S + S E S+ + + +E E EEEE +
Sbjct: 1361 EKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSEL 1420
Query: 1296 SRKRLHRIET---DEEESCDNAHGDANQ-----------PARDSQPRV-LPSEQESTKKP 1340
+ + +++ +E + A+ D + D P++ + + +++
Sbjct: 1421 DLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHN 1480
Query: 1341 YRIESDEEEDFENVGKVGSP----LDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKD 1396
I S + ++V V SP L+ + G +++N+ P + D
Sbjct: 1481 SPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSD 1540
Query: 1397 NS 1398
+S
Sbjct: 1541 HS 1542
Score = 50.4 bits (119), Expect = 1e-05
Identities = 146/713 (20%), Positives = 251/713 (35%), Gaps = 128/713 (17%)
Query: 757 NKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQK 816
+++E+ E EE + + R IS K +++ D E E + E +
Sbjct: 787 SEEEEEEAEEGENEEPQCQERELEIS--VGKSVSHENKEQDSYSVESEKKPEVMAPVSST 844
Query: 817 TDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSND-------------ESE 863
K++L NS+ P + RW + + ++ D E
Sbjct: 845 RLSKQVLPHDSLPANSQ-----PSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQY 899
Query: 864 GSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRP 923
G EKS A +E+ ESEE ++A +++P + G P+ P+ L G R
Sbjct: 900 GECGEKSEAT--QEQYTESEEQLVASEEQPSQD-GKPDLPKRRL-----SEGVEP--WRG 949
Query: 924 PLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKK--KERAERRKERLVYVGISIENI 981
L P+ C+ E+L + + D A+ + E +E +E
Sbjct: 950 QLKKSPEAL----KCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEE------------ 993
Query: 982 IPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRK-----CISYRFDEFDEAIDEAIED 1036
P+ P S K K+ K L RR R RK ++ E E +DE ED
Sbjct: 994 --PESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFED 1051
Query: 1037 DIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDS 1096
E + +I +EE EN+ R R + L S
Sbjct: 1052 SDSERPMPRLEPTFEIDEE------------EEEEDENELFPREYFRRLSSQDVLRCQSS 1099
Query: 1097 DSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPS--- 1153
++E EDE SD + D ++ + + S + DT ++ + P
Sbjct: 1100 SKRKSKDEEEDEE--SDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKS 1157
Query: 1154 -RPMRQSRRLRRKTPKKKYSDDDEEEESE--------------ENSRDSESDFSDDFSDD 1198
+P+ +R RK P K S + ++ + ES+ + + +D
Sbjct: 1158 RKPIHWKKRPGRK-PGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKED 1216
Query: 1199 FVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNS 1258
R+ + + E+ E + + S S ++S S ++
Sbjct: 1217 MPLPEERKEEEEMQAEAEEAEEGEEEDAASS----------EVPAASPADSSNSPETETK 1266
Query: 1259 EDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDA 1318
E + +E K V + R ++E E E EE E E +E+ + + A D
Sbjct: 1267 EPEVEEEEEKPRVSEEQRQSEE--EQQELEEPEP-----------EEEEDAAAETAQNDD 1313
Query: 1319 NQPARDSQPRVLPSEQESTKKPYRIESDEEEDF-ENVGKVGSPLDYSLVDLPSTNGQSPG 1377
+ + + ESTKK E ED E G S LD ++ + +
Sbjct: 1314 HDADDEDDGHL-----ESTKKKELEEQPTREDVKEEPGVQESFLD---ANMQKSREKIKD 1365
Query: 1378 KAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEE-----EEDEL 1425
K L +E+ Q D S S +A + +++ EE EE+E+
Sbjct: 1366 KEETEL---DSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEI 1415
Score = 48.5 bits (114), Expect = 5e-05
Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 4/58 (6%)
Query: 894 CKKCGL----PNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKL 947
CK C + + +L CDSCD G+H C PPL +P G W C C+ + KL
Sbjct: 262 CKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKL 319
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/174 (24%), Positives = 80/174 (45%), Gaps = 25/174 (14%)
Query: 216 NSSQQDNSSRESPSLEDEETK---KEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLE 272
+SS + + P +E+EE K EE+ +EEQ+E E+ + EE E + A +
Sbjct: 1256 DSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEE-----EEDAAAETAQ 1310
Query: 273 ETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEE---SDSFKE-NVKPIKVEVK- 327
+ ED+ L +K L E ++ +KEE +SF + N++ + ++K
Sbjct: 1311 NDDHDADDEDDGHLESTK-----KKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKD 1365
Query: 328 --ECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQ 379
E D ++ + S + V E + G+ + HE + EE +LK +++
Sbjct: 1366 KEETELDSEEEQPSHDTSVVSE----QMAGS-EDDHEEDSHTKEELIELKEEEE 1414
Score = 42.0 bits (97), Expect = 0.004
Identities = 94/397 (23%), Positives = 153/397 (38%), Gaps = 76/397 (19%)
Query: 223 SSRESPSLEDEET-KKEEETPKQEEQKESEKMKSE-EQPMDLENRSTA------------ 268
+ R+ E EET + +E+ P EE+KE E+M++E E+ + E A
Sbjct: 1198 AGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADS 1257
Query: 269 -NVLEETTVKKEKEDEKELVKLPVIVK--------LEKPLPENEEKKIIK---------- 309
N E T + E E+E+E ++ + LE+P PE EE +
Sbjct: 1258 SNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDAD 1317
Query: 310 EESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTE 369
+E D E+ K ++E + R D K E+P QE N++ S E K E
Sbjct: 1318 DEDDGHLESTKKKELEEQPTREDVK------EEPGVQES---FLDANMQKSRE-KIKDKE 1367
Query: 370 ETEKLKNDQQAK--IPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKR 427
ETE ++Q + ++ S+D D + + KE ++EI E +
Sbjct: 1368 ETELDSEEEQPSHDTSVVSEQMAGSED-DHEEDSHTKEELIELKE--EEEIPHSELDLET 1424
Query: 428 ISTITALGHEGKQLVNGEVSD-ERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNG 486
+ + +L E G D E +T T+ E + S + E
Sbjct: 1425 VQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMS---------MVEDCH 1475
Query: 487 TESLNSVITSMKTGELEKETAPLRKDADSSISVLE-----IHSQKAQIEEPDPPEMETS- 540
NS I+S+++ + +R + ++ LE I ++ + P METS
Sbjct: 1476 ASEHNSPISSVQS----HPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSP 1531
Query: 541 -------LDSSEMAKDLSSKTALSSTESCTMKGEEKS 570
D S+ D S + L S ES T E S
Sbjct: 1532 MMDVPSVSDHSQQVVD-SGFSDLGSIESTTENYENPS 1567
>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 72.8 bits (177), Expect = 2e-12
Identities = 164/754 (21%), Positives = 296/754 (39%), Gaps = 104/754 (13%)
Query: 171 HNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSL 230
H++RM ++ + DQ I+R + + +A L+ + PV R +P +
Sbjct: 732 HHLRM-LDFRSDQF-----VIIRREKLIQDHMAKLQLNLRPV-----DVDPECLRWTPVI 780
Query: 231 EDEETKKEEETPKQEEQKESEKMKSEEQPMDLE-NRSTANVLEETTVKKEKEDEKELVKL 289
EEE + EE E+E+ + +E+ +++ +S ++ +E + ++K V
Sbjct: 781 VSNSVVSEEEEEEAEEG-ENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMA 839
Query: 290 PVI-VKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEP 348
PV +L K + ++ + S + K K + R KD+K +E+ +
Sbjct: 840 PVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQE---RFGDKDSKLLLEETSSAPQ 896
Query: 349 ERIEFGGNIKSSHEITEKSTEETEKL-----KNDQQAKIPLKKREIKLSDDFDSPVKGPL 403
E ++G + S E+ TE E+L + Q K L KR +LS+ + P +G L
Sbjct: 897 E--QYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKR--RLSEGVE-PWRGQL 951
Query: 404 CKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLV------NGEVSDERVAPNFKT 457
KS E LK + + E R + EG + V + E +E +P +
Sbjct: 952 KKS----PEALKCRLTEGSERLPRRYS------EGDRAVLRGFSESSEEEEEPESPRSSS 1001
Query: 458 EPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSI 517
PI TK +++ + + R + + + SV+T + E P +D+DS
Sbjct: 1002 PPILTKPTLKRKKPFLHRRRRVRKRKHHNS----SVVTETISETTEVLDEPF-EDSDSER 1056
Query: 518 SVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDK 577
+ + +I+E + E E L E + LSS+ L S K +++ + D
Sbjct: 1057 PMPRLEPT-FEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDD 1115
Query: 578 RP--PILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNII 635
PIL+ + L K + + P E ST +K G P+ P
Sbjct: 1116 ADDTPILKPVSLLRK----------RDVKNSPLEPDTSTPLKKKKGWPKGKSRKPI---- 1161
Query: 636 DHCEKLASEKEVVEC-QSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEP 694
H +K K + + V Q+ + ++ + K++ ++ EP
Sbjct: 1162 -HWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQ-------ESEETVEP 1213
Query: 695 SETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLE 754
E ++ K EEE +E E +++ + +S +SP E
Sbjct: 1214 KEDMPLPEERK-------EEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSP----E 1262
Query: 755 PENKQEKTEKEEEKTNVGRTLRRSPRISR--PTAKVAEIRDQKADKKRGEGEDEVEEEST 812
E K+ + E+EEEK V R+S + + E D A+ + + D +E+
Sbjct: 1263 TETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDG 1322
Query: 813 ALQKTDKKEI--------------LKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSS 858
L+ T KKE+ +++S D N + S+ K K K + + S
Sbjct: 1323 HLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEE---TELDSEEEQPS 1379
Query: 859 NDESEGSGSEKSSAASEEEEEKESEEAILADDDE 892
+D S S S EE+ EE I ++E
Sbjct: 1380 HDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEE 1413
Score = 52.0 bits (123), Expect = 4e-06
Identities = 83/377 (22%), Positives = 138/377 (36%), Gaps = 65/377 (17%)
Query: 990 SEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRG 1049
SE++EE+ ++ + + ER E + ++ +++ + KE D V
Sbjct: 787 SEEEEEEAEEGENEEPQCQER--------------ELEISVGKSVSHENKEQDSYSVESE 832
Query: 1050 KDISTITGHRGKDIS--TILDEERKENKRPQRAAAARRKKRR---RLNDLDSDSNLDEEE 1104
K + +S + + N +P R RK R+ R D DS L+E
Sbjct: 833 KKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETS 892
Query: 1105 SEDEFKI------SDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQ 1158
S + + S+ +Q+++ S+E SEE P + D D RRL S +
Sbjct: 893 SAPQEQYGECGEKSEATQEQYTESEEQLVASEEQP--SQDGKPDLPKRRL----SEGVEP 946
Query: 1159 SRRLRRKTPKK-KYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINY 1217
R +K+P+ K + E + + FS+ E S R+ I
Sbjct: 947 WRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILT 1006
Query: 1218 KEDSESDGSQKSLRRGKEI----RRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRK 1273
K +L+R K RRV KR+ +S +S+
Sbjct: 1007 KP---------TLKRKKPFLHRRRRVRKRKHHNSSVVTETISE----------------- 1040
Query: 1274 RGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSE 1333
+T+ E E+ + E P + I+ +EEE +N R S VL +
Sbjct: 1041 ---TTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQ 1097
Query: 1334 QESTKKPYRIESDEEED 1350
S +K E DEE D
Sbjct: 1098 SSSKRKSKDEEEDEESD 1114
Score = 50.8 bits (120), Expect = 9e-06
Identities = 146/782 (18%), Positives = 271/782 (34%), Gaps = 126/782 (16%)
Query: 713 EEETTASENTEITSERQKEGIKLTIRISSRKKKPDS-------PPKVLEP--ENKQEKTE 763
EEE EN E + ++ I + +S K+ DS P+V+ P + K
Sbjct: 791 EEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQV 850
Query: 764 KEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGE----------GEDEVEEESTA 813
+ R R R K E K K E GE + E+T
Sbjct: 851 LPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQ 910
Query: 814 LQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDES--EGSGSEKSS 871
Q T+ +E L SE+ + PK ++ RG+ K S GSE+
Sbjct: 911 EQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLP 970
Query: 872 AASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDG 931
E + A+L E ++ P P PP++ P
Sbjct: 971 -----RRYSEGDRAVLRGFSESSEEEEEPESPR---------------SSSPPILTKPTL 1010
Query: 932 EWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSE 991
+ P + K + + V E E E + E +P EP F
Sbjct: 1011 KRKKPFLHRRRRVRKRKHHNSSV-VTETISETTEVLDEP--FEDSDSERPMPRLEPTFEI 1067
Query: 992 DQEEKKKDSKK----------SKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEA 1041
D+EE+++D + S ++L +S+ RK + +E DE D+A DD
Sbjct: 1068 DEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKS---KDEEEDEESDDA--DDTPIL 1122
Query: 1042 DGGGVGRGKDISTITGHRGKDISTILDEER-----------KENKRPQRAA--------- 1081
+ R +D+ D ST L +++ KRP R
Sbjct: 1123 KPVSLLRKRDVKN--SPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIM 1180
Query: 1082 -----------------AARRKKRRRLNDLDS--------DSNLDEEESEDEFKISDGSQ 1116
A R+ K + + + +EEE + E + ++ +
Sbjct: 1181 PVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGE 1240
Query: 1117 DEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDE 1176
+E S E P S D ++ +++T R + R+ + + + + +E
Sbjct: 1241 EEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEE 1300
Query: 1177 EEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEI 1236
EE++ + ++ +DD D +E+ +++ Q + + KE+ S K
Sbjct: 1301 EEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSR 1360
Query: 1237 RRVHKRRLSSSESEESYLSKN-SEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKP 1295
++ + + +SEE S + S E S+ + + +E E EEEE +
Sbjct: 1361 EKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSEL 1420
Query: 1296 SRKRLHRIET---DEEESCDNAHGDANQ-----------PARDSQPRV-LPSEQESTKKP 1340
+ + +++ +E + A+ D + D P++ + + +++
Sbjct: 1421 DLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHN 1480
Query: 1341 YRIESDEEEDFENVGKVGSP----LDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKD 1396
I S + ++V V SP L+ + G +++N+ P + D
Sbjct: 1481 SPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSD 1540
Query: 1397 NS 1398
+S
Sbjct: 1541 HS 1542
Score = 50.4 bits (119), Expect = 1e-05
Identities = 146/713 (20%), Positives = 251/713 (35%), Gaps = 128/713 (17%)
Query: 757 NKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQK 816
+++E+ E EE + + R IS K +++ D E E + E +
Sbjct: 787 SEEEEEEAEEGENEEPQCQERELEIS--VGKSVSHENKEQDSYSVESEKKPEVMAPVSST 844
Query: 817 TDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSND-------------ESE 863
K++L NS+ P + RW + + ++ D E
Sbjct: 845 RLSKQVLPHDSLPANSQ-----PSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQY 899
Query: 864 GSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRP 923
G EKS A +E+ ESEE ++A +++P + G P+ P+ L G R
Sbjct: 900 GECGEKSEAT--QEQYTESEEQLVASEEQPSQD-GKPDLPKRRL-----SEGVEP--WRG 949
Query: 924 PLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKK--KERAERRKERLVYVGISIENI 981
L P+ C+ E+L + + D A+ + E +E +E
Sbjct: 950 QLKKSPEAL----KCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEE------------ 993
Query: 982 IPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRK-----CISYRFDEFDEAIDEAIED 1036
P+ P S K K+ K L RR R RK ++ E E +DE ED
Sbjct: 994 --PESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFED 1051
Query: 1037 DIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDS 1096
E + +I +EE EN+ R R + L S
Sbjct: 1052 SDSERPMPRLEPTFEIDEE------------EEEEDENELFPREYFRRLSSQDVLRCQSS 1099
Query: 1097 DSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPS--- 1153
++E EDE SD + D ++ + + S + DT ++ + P
Sbjct: 1100 SKRKSKDEEEDEE--SDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKS 1157
Query: 1154 -RPMRQSRRLRRKTPKKKYSDDDEEEESE--------------ENSRDSESDFSDDFSDD 1198
+P+ +R RK P K S + ++ + ES+ + + +D
Sbjct: 1158 RKPIHWKKRPGRK-PGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKED 1216
Query: 1199 FVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNS 1258
R+ + + E+ E + + S S ++S S ++
Sbjct: 1217 MPLPEERKEEEEMQAEAEEAEEGEEEDAASS----------EVPAASPADSSNSPETETK 1266
Query: 1259 EDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDA 1318
E + +E K V + R ++E E E EE E E +E+ + + A D
Sbjct: 1267 EPEVEEEEEKPRVSEEQRQSEE--EQQELEEPEP-----------EEEEDAAAETAQNDD 1313
Query: 1319 NQPARDSQPRVLPSEQESTKKPYRIESDEEEDF-ENVGKVGSPLDYSLVDLPSTNGQSPG 1377
+ + + ESTKK E ED E G S LD ++ + +
Sbjct: 1314 HDADDEDDGHL-----ESTKKKELEEQPTREDVKEEPGVQESFLD---ANMQKSREKIKD 1365
Query: 1378 KAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEE-----EEDEL 1425
K L +E+ Q D S S +A + +++ EE EE+E+
Sbjct: 1366 KEETEL---DSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEI 1415
Score = 48.5 bits (114), Expect = 5e-05
Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 4/58 (6%)
Query: 894 CKKCGL----PNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKL 947
CK C + + +L CDSCD G+H C PPL +P G W C C+ + KL
Sbjct: 262 CKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKL 319
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/174 (24%), Positives = 80/174 (45%), Gaps = 25/174 (14%)
Query: 216 NSSQQDNSSRESPSLEDEETK---KEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLE 272
+SS + + P +E+EE K EE+ +EEQ+E E+ + EE E + A +
Sbjct: 1256 DSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEE-----EEDAAAETAQ 1310
Query: 273 ETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEE---SDSFKE-NVKPIKVEVK- 327
+ ED+ L +K L E ++ +KEE +SF + N++ + ++K
Sbjct: 1311 NDDHDADDEDDGHLESTK-----KKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKD 1365
Query: 328 --ECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQ 379
E D ++ + S + V E + G+ + HE + EE +LK +++
Sbjct: 1366 KEETELDSEEEQPSHDTSVVSE----QMAGS-EDDHEEDSHTKEELIELKEEEE 1414
Score = 42.0 bits (97), Expect = 0.004
Identities = 94/397 (23%), Positives = 153/397 (38%), Gaps = 76/397 (19%)
Query: 223 SSRESPSLEDEET-KKEEETPKQEEQKESEKMKSE-EQPMDLENRSTA------------ 268
+ R+ E EET + +E+ P EE+KE E+M++E E+ + E A
Sbjct: 1198 AGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADS 1257
Query: 269 -NVLEETTVKKEKEDEKELVKLPVIVK--------LEKPLPENEEKKIIK---------- 309
N E T + E E+E+E ++ + LE+P PE EE +
Sbjct: 1258 SNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDAD 1317
Query: 310 EESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTE 369
+E D E+ K ++E + R D K E+P QE N++ S E K E
Sbjct: 1318 DEDDGHLESTKKKELEEQPTREDVK------EEPGVQES---FLDANMQKSRE-KIKDKE 1367
Query: 370 ETEKLKNDQQAK--IPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKR 427
ETE ++Q + ++ S+D D + + KE ++EI E +
Sbjct: 1368 ETELDSEEEQPSHDTSVVSEQMAGSED-DHEEDSHTKEELIELKE--EEEIPHSELDLET 1424
Query: 428 ISTITALGHEGKQLVNGEVSD-ERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNG 486
+ + +L E G D E +T T+ E + S + E
Sbjct: 1425 VQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMS---------MVEDCH 1475
Query: 487 TESLNSVITSMKTGELEKETAPLRKDADSSISVLE-----IHSQKAQIEEPDPPEMETS- 540
NS I+S+++ + +R + ++ LE I ++ + P METS
Sbjct: 1476 ASEHNSPISSVQS----HPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSP 1531
Query: 541 -------LDSSEMAKDLSSKTALSSTESCTMKGEEKS 570
D S+ D S + L S ES T E S
Sbjct: 1532 MMDVPSVSDHSQQVVD-SGFSDLGSIESTTENYENPS 1567
>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
[Homo sapiens]
Length = 2004
Score = 72.8 bits (177), Expect = 2e-12
Identities = 164/754 (21%), Positives = 296/754 (39%), Gaps = 104/754 (13%)
Query: 171 HNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSL 230
H++RM ++ + DQ I+R + + +A L+ + PV R +P +
Sbjct: 732 HHLRM-LDFRSDQF-----VIIRREKLIQDHMAKLQLNLRPV-----DVDPECLRWTPVI 780
Query: 231 EDEETKKEEETPKQEEQKESEKMKSEEQPMDLE-NRSTANVLEETTVKKEKEDEKELVKL 289
EEE + EE E+E+ + +E+ +++ +S ++ +E + ++K V
Sbjct: 781 VSNSVVSEEEEEEAEEG-ENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMA 839
Query: 290 PVI-VKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEP 348
PV +L K + ++ + S + K K + R KD+K +E+ +
Sbjct: 840 PVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQE---RFGDKDSKLLLEETSSAPQ 896
Query: 349 ERIEFGGNIKSSHEITEKSTEETEKL-----KNDQQAKIPLKKREIKLSDDFDSPVKGPL 403
E ++G + S E+ TE E+L + Q K L KR +LS+ + P +G L
Sbjct: 897 E--QYGECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKR--RLSEGVE-PWRGQL 951
Query: 404 CKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLV------NGEVSDERVAPNFKT 457
KS E LK + + E R + EG + V + E +E +P +
Sbjct: 952 KKS----PEALKCRLTEGSERLPRRYS------EGDRAVLRGFSESSEEEEEPESPRSSS 1001
Query: 458 EPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSI 517
PI TK +++ + + R + + + SV+T + E P +D+DS
Sbjct: 1002 PPILTKPTLKRKKPFLHRRRRVRKRKHHNS----SVVTETISETTEVLDEPF-EDSDSER 1056
Query: 518 SVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDK 577
+ + +I+E + E E L E + LSS+ L S K +++ + D
Sbjct: 1057 PMPRLEPT-FEIDEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDD 1115
Query: 578 RP--PILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNII 635
PIL+ + L K + + P E ST +K G P+ P
Sbjct: 1116 ADDTPILKPVSLLRK----------RDVKNSPLEPDTSTPLKKKKGWPKGKSRKPI---- 1161
Query: 636 DHCEKLASEKEVVEC-QSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEP 694
H +K K + + V Q+ + ++ + K++ ++ EP
Sbjct: 1162 -HWKKRPGRKPGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQ-------ESEETVEP 1213
Query: 695 SETKGSMQKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLE 754
E ++ K EEE +E E +++ + +S +SP E
Sbjct: 1214 KEDMPLPEERK-------EEEEMQAEAEEAEEGEEEDAASSEVPAASPADSSNSP----E 1262
Query: 755 PENKQEKTEKEEEKTNVGRTLRRSPRISR--PTAKVAEIRDQKADKKRGEGEDEVEEEST 812
E K+ + E+EEEK V R+S + + E D A+ + + D +E+
Sbjct: 1263 TETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDADDEDDG 1322
Query: 813 ALQKTDKKEI--------------LKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSS 858
L+ T KKE+ +++S D N + S+ K K K + + S
Sbjct: 1323 HLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKDKEE---TELDSEEEQPS 1379
Query: 859 NDESEGSGSEKSSAASEEEEEKESEEAILADDDE 892
+D S S S EE+ EE I ++E
Sbjct: 1380 HDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEE 1413
Score = 52.0 bits (123), Expect = 4e-06
Identities = 83/377 (22%), Positives = 138/377 (36%), Gaps = 65/377 (17%)
Query: 990 SEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRG 1049
SE++EE+ ++ + + ER E + ++ +++ + KE D V
Sbjct: 787 SEEEEEEAEEGENEEPQCQER--------------ELEISVGKSVSHENKEQDSYSVESE 832
Query: 1050 KDISTITGHRGKDIS--TILDEERKENKRPQRAAAARRKKRR---RLNDLDSDSNLDEEE 1104
K + +S + + N +P R RK R+ R D DS L+E
Sbjct: 833 KKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETS 892
Query: 1105 SEDEFKI------SDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQ 1158
S + + S+ +Q+++ S+E SEE P + D D RRL S +
Sbjct: 893 SAPQEQYGECGEKSEATQEQYTESEEQLVASEEQP--SQDGKPDLPKRRL----SEGVEP 946
Query: 1159 SRRLRRKTPKK-KYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINY 1217
R +K+P+ K + E + + FS+ E S R+ I
Sbjct: 947 WRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILT 1006
Query: 1218 KEDSESDGSQKSLRRGKEI----RRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRK 1273
K +L+R K RRV KR+ +S +S+
Sbjct: 1007 KP---------TLKRKKPFLHRRRRVRKRKHHNSSVVTETISE----------------- 1040
Query: 1274 RGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSE 1333
+T+ E E+ + E P + I+ +EEE +N R S VL +
Sbjct: 1041 ---TTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELFPREYFRRLSSQDVLRCQ 1097
Query: 1334 QESTKKPYRIESDEEED 1350
S +K E DEE D
Sbjct: 1098 SSSKRKSKDEEEDEESD 1114
Score = 50.8 bits (120), Expect = 9e-06
Identities = 146/782 (18%), Positives = 271/782 (34%), Gaps = 126/782 (16%)
Query: 713 EEETTASENTEITSERQKEGIKLTIRISSRKKKPDS-------PPKVLEP--ENKQEKTE 763
EEE EN E + ++ I + +S K+ DS P+V+ P + K
Sbjct: 791 EEEAEEGENEEPQCQERELEISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQV 850
Query: 764 KEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGE----------GEDEVEEESTA 813
+ R R R K E K K E GE + E+T
Sbjct: 851 LPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYGECGEKSEATQ 910
Query: 814 LQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDES--EGSGSEKSS 871
Q T+ +E L SE+ + PK ++ RG+ K S GSE+
Sbjct: 911 EQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLP 970
Query: 872 AASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDG 931
E + A+L E ++ P P PP++ P
Sbjct: 971 -----RRYSEGDRAVLRGFSESSEEEEEPESPR---------------SSSPPILTKPTL 1010
Query: 932 EWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSE 991
+ P + K + + V E E E + E +P EP F
Sbjct: 1011 KRKKPFLHRRRRVRKRKHHNSSV-VTETISETTEVLDEP--FEDSDSERPMPRLEPTFEI 1067
Query: 992 DQEEKKKDSKK----------SKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEA 1041
D+EE+++D + S ++L +S+ RK + +E DE D+A DD
Sbjct: 1068 DEEEEEEDENELFPREYFRRLSSQDVLRCQSSSKRKS---KDEEEDEESDDA--DDTPIL 1122
Query: 1042 DGGGVGRGKDISTITGHRGKDISTILDEER-----------KENKRPQRAA--------- 1081
+ R +D+ D ST L +++ KRP R
Sbjct: 1123 KPVSLLRKRDVKN--SPLEPDTSTPLKKKKGWPKGKSRKPIHWKKRPGRKPGFKLSREIM 1180
Query: 1082 -----------------AARRKKRRRLNDLDS--------DSNLDEEESEDEFKISDGSQ 1116
A R+ K + + + +EEE + E + ++ +
Sbjct: 1181 PVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGE 1240
Query: 1117 DEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDE 1176
+E S E P S D ++ +++T R + R+ + + + + +E
Sbjct: 1241 EEDAASSEVPAASPADSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEE 1300
Query: 1177 EEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEI 1236
EE++ + ++ +DD D +E+ +++ Q + + KE+ S K
Sbjct: 1301 EEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQPTREDVKEEPGVQESFLDANMQKSR 1360
Query: 1237 RRVHKRRLSSSESEESYLSKN-SEDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKP 1295
++ + + +SEE S + S E S+ + + +E E EEEE +
Sbjct: 1361 EKIKDKEETELDSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEIPHSEL 1420
Query: 1296 SRKRLHRIET---DEEESCDNAHGDANQ-----------PARDSQPRV-LPSEQESTKKP 1340
+ + +++ +E + A+ D + D P++ + + +++
Sbjct: 1421 DLETVQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMSMVEDCHASEHN 1480
Query: 1341 YRIESDEEEDFENVGKVGSP----LDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKD 1396
I S + ++V V SP L+ + G +++N+ P + D
Sbjct: 1481 SPISSVQSHPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSD 1540
Query: 1397 NS 1398
+S
Sbjct: 1541 HS 1542
Score = 50.4 bits (119), Expect = 1e-05
Identities = 146/713 (20%), Positives = 251/713 (35%), Gaps = 128/713 (17%)
Query: 757 NKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQK 816
+++E+ E EE + + R IS K +++ D E E + E +
Sbjct: 787 SEEEEEEAEEGENEEPQCQERELEIS--VGKSVSHENKEQDSYSVESEKKPEVMAPVSST 844
Query: 817 TDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSND-------------ESE 863
K++L NS+ P + RW + + ++ D E
Sbjct: 845 RLSKQVLPHDSLPANSQ-----PSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQY 899
Query: 864 GSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRP 923
G EKS A +E+ ESEE ++A +++P + G P+ P+ L G R
Sbjct: 900 GECGEKSEAT--QEQYTESEEQLVASEEQPSQD-GKPDLPKRRL-----SEGVEP--WRG 949
Query: 924 PLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKK--KERAERRKERLVYVGISIENI 981
L P+ C+ E+L + + D A+ + E +E +E
Sbjct: 950 QLKKSPEAL----KCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEE------------ 993
Query: 982 IPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRK-----CISYRFDEFDEAIDEAIED 1036
P+ P S K K+ K L RR R RK ++ E E +DE ED
Sbjct: 994 --PESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFED 1051
Query: 1037 DIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDLDS 1096
E + +I +EE EN+ R R + L S
Sbjct: 1052 SDSERPMPRLEPTFEIDEE------------EEEEDENELFPREYFRRLSSQDVLRCQSS 1099
Query: 1097 DSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPS--- 1153
++E EDE SD + D ++ + + S + DT ++ + P
Sbjct: 1100 SKRKSKDEEEDEE--SDDADDTPILKPVSLLRKRDVKNSPLEPDTSTPLKKKKGWPKGKS 1157
Query: 1154 -RPMRQSRRLRRKTPKKKYSDDDEEEESE--------------ENSRDSESDFSDDFSDD 1198
+P+ +R RK P K S + ++ + ES+ + + +D
Sbjct: 1158 RKPIHWKKRPGRK-PGFKLSREIMPVSTQACVIEPIVSIPKAGRKPKIQESEETVEPKED 1216
Query: 1199 FVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNS 1258
R+ + + E+ E + + S S ++S S ++
Sbjct: 1217 MPLPEERKEEEEMQAEAEEAEEGEEEDAASS----------EVPAASPADSSNSPETETK 1266
Query: 1259 EDDELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDA 1318
E + +E K V + R ++E E E EE E E +E+ + + A D
Sbjct: 1267 EPEVEEEEEKPRVSEEQRQSEE--EQQELEEPEP-----------EEEEDAAAETAQNDD 1313
Query: 1319 NQPARDSQPRVLPSEQESTKKPYRIESDEEEDF-ENVGKVGSPLDYSLVDLPSTNGQSPG 1377
+ + + ESTKK E ED E G S LD ++ + +
Sbjct: 1314 HDADDEDDGHL-----ESTKKKELEEQPTREDVKEEPGVQESFLD---ANMQKSREKIKD 1365
Query: 1378 KAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEE-----EEDEL 1425
K L +E+ Q D S S +A + +++ EE EE+E+
Sbjct: 1366 KEETEL---DSEEEQPSHDTSVVSEQMAGSEDDHEEDSHTKEELIELKEEEEI 1415
Score = 48.5 bits (114), Expect = 5e-05
Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 4/58 (6%)
Query: 894 CKKCGL----PNHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKL 947
CK C + + +L CDSCD G+H C PPL +P G W C C+ + KL
Sbjct: 262 CKTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKL 319
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/174 (24%), Positives = 80/174 (45%), Gaps = 25/174 (14%)
Query: 216 NSSQQDNSSRESPSLEDEETK---KEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLE 272
+SS + + P +E+EE K EE+ +EEQ+E E+ + EE E + A +
Sbjct: 1256 DSSNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEE-----EEDAAAETAQ 1310
Query: 273 ETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEE---SDSFKE-NVKPIKVEVK- 327
+ ED+ L +K L E ++ +KEE +SF + N++ + ++K
Sbjct: 1311 NDDHDADDEDDGHLESTK-----KKELEEQPTREDVKEEPGVQESFLDANMQKSREKIKD 1365
Query: 328 --ECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQ 379
E D ++ + S + V E + G+ + HE + EE +LK +++
Sbjct: 1366 KEETELDSEEEQPSHDTSVVSE----QMAGS-EDDHEEDSHTKEELIELKEEEE 1414
Score = 42.0 bits (97), Expect = 0.004
Identities = 94/397 (23%), Positives = 153/397 (38%), Gaps = 76/397 (19%)
Query: 223 SSRESPSLEDEET-KKEEETPKQEEQKESEKMKSE-EQPMDLENRSTA------------ 268
+ R+ E EET + +E+ P EE+KE E+M++E E+ + E A
Sbjct: 1198 AGRKPKIQESEETVEPKEDMPLPEERKEEEEMQAEAEEAEEGEEEDAASSEVPAASPADS 1257
Query: 269 -NVLEETTVKKEKEDEKELVKLPVIVK--------LEKPLPENEEKKIIK---------- 309
N E T + E E+E+E ++ + LE+P PE EE +
Sbjct: 1258 SNSPETETKEPEVEEEEEKPRVSEEQRQSEEEQQELEEPEPEEEEDAAAETAQNDDHDAD 1317
Query: 310 EESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTE 369
+E D E+ K ++E + R D K E+P QE N++ S E K E
Sbjct: 1318 DEDDGHLESTKKKELEEQPTREDVK------EEPGVQES---FLDANMQKSRE-KIKDKE 1367
Query: 370 ETEKLKNDQQAK--IPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKR 427
ETE ++Q + ++ S+D D + + KE ++EI E +
Sbjct: 1368 ETELDSEEEQPSHDTSVVSEQMAGSED-DHEEDSHTKEELIELKE--EEEIPHSELDLET 1424
Query: 428 ISTITALGHEGKQLVNGEVSD-ERVAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNG 486
+ + +L E G D E +T T+ E + S + E
Sbjct: 1425 VQAVQSLTQEESSEHEGAYQDCEETLAACQTLQSYTQADEDPQMS---------MVEDCH 1475
Query: 487 TESLNSVITSMKTGELEKETAPLRKDADSSISVLE-----IHSQKAQIEEPDPPEMETS- 540
NS I+S+++ + +R + ++ LE I ++ + P METS
Sbjct: 1476 ASEHNSPISSVQS----HPSQSVRSVSSPNVPALESGYTQISPEQGSLSAPSMQNMETSP 1531
Query: 541 -------LDSSEMAKDLSSKTALSSTESCTMKGEEKS 570
D S+ D S + L S ES T E S
Sbjct: 1532 MMDVPSVSDHSQQVVD-SGFSDLGSIESTTENYENPS 1567
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 72.0 bits (175), Expect = 4e-12
Identities = 221/1196 (18%), Positives = 459/1196 (38%), Gaps = 211/1196 (17%)
Query: 231 EDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANVLEETTVKKEKEDEKELVKLP 290
E EE + E +EE++ + +++E++ M + LEE ++K +L K+
Sbjct: 912 ELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK---LQLEKVT 968
Query: 291 VIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPER 350
KL+K EE+ I+++++ + K ++ + E + + +E E+
Sbjct: 969 TEAKLKK---LEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN-----------LTEEEEK 1014
Query: 351 IEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPT 410
+ +K+ HE T+ E+L+ +++ + L+K KL D
Sbjct: 1015 SKSLAKLKNKHE--AMITDLEERLRREEKQRQELEKTRRKLEGDSTD------------- 1059
Query: 411 KEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNF---KTEPIETKFYET 467
L D+I + + + A E Q V +E N K +E++ E
Sbjct: 1060 ---LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 468 KEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKA 527
+E+ S RN + EK+ ++D + L+
Sbjct: 1117 QEDLESERASRN---------------------KAEKQ----KRDLGEELEALK------ 1145
Query: 528 QIEEPDPPEMETSLDSSEMAKDLSSK-----TALSSTESCTMKGEEKSPKTKKDKRPPIL 582
E+E +LDS+ ++L SK L T K E + + K +
Sbjct: 1146 -------TELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAV 1198
Query: 583 ECL-EKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSPPSNIIDHCEKL 641
E L E+LE++K+ + E K TLE+E+ + ++
Sbjct: 1199 EELAEQLEQTKRVKANL----------EKAKQTLENERGELANEVKVLLQGKGDSEHKRK 1248
Query: 642 ASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSM 701
E ++ E Q G ++V E L + +VE+DN+ +G+ S++K S
Sbjct: 1249 KVEAQLQELQVKFNEG----ERVRTE-LADKVTKLQVELDNV-----TGLLSQSDSKSSK 1298
Query: 702 QKSKFKYKLVPEEETTASENTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEK 761
F E+ + E+ E ++ + L+ ++ + + +S + LE
Sbjct: 1299 LTKDFS-----ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE------- 1346
Query: 762 TEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEESTALQKTDKKE 821
E+EE K N+ + ++A + Q AD K+ + ED V TA +E
Sbjct: 1347 -EEEEAKHNLEK-------------QIATLHAQVADMKK-KMEDSVGCLETA------EE 1385
Query: 822 ILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKE 881
+ +K +KD + + K +T+ R + +D ++ SA + E+++K+
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 882 SEE---------AILADDDEPCKKCGLPNHPELILLCDSCDSGYHTAC--------LRPP 924
++ A A++ + + + + L + + R
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 925 LMIIPDGEWFCPPCQHKLLCEK--LEEQLQDLDVALKK-KERAERRKERLVYVGISIENI 981
+ + + H+L K LE+Q++++ L++ ++ + ++ + + ++++ +
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 982 IPPQEPDF---SEDQEEKKK----DSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAI 1034
E D E EEKKK ++ +A L + R R+ + + E D +
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMD------L 1619
Query: 1035 EDDIKEADGGGVGRGKDISTITGHRG--KDISTILDEERKENKRPQRAAAARRKKRRRLN 1092
+D D R + I + + KD LD+ R + A ++ ++L
Sbjct: 1620 KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASR---EEILAQAKENEKKLK 1676
Query: 1093 DLDSDS-NLDEEESEDEFKISDGSQDEFVVSDENPDESE-------------------ED 1132
++++ L EE + E Q+ ++DE + S E+
Sbjct: 1677 SMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEE 1736
Query: 1133 PPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFS 1192
+ +T+ + RL++ + + + L ++ ++ +E + ++ E
Sbjct: 1737 ELEEEQGNTELINDRLKKANLQIDQINTDLNL---ERSHAQKNENARQQLERQNKELKVK 1793
Query: 1193 DDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEES 1252
+ V+++ + S + +I E+ + +++ K++RR K +L +
Sbjct: 1794 LQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK-KLKDVLLQVD 1852
Query: 1253 YLSKNSED--DELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEES 1310
+N+E D+ K S R +++ R +E EEE + SR++L R D E+
Sbjct: 1853 DERRNAEQYKDQADKASTR-LKQLKRQLEE-----AEEEAQRANASRRKLQRELEDATET 1906
Query: 1311 CDNAHGDA----NQPARDSQPRVLPSEQESTKKPYRIESDEEEDFENVGKVGSPLD 1362
D + + N+ R P V+P + +K SDEE D + G P +
Sbjct: 1907 ADAMNREVSSLKNKLRRGDLPFVVP--RRMARKGAGDGSDEEVDGKADGAEAKPAE 1960
Score = 71.2 bits (173), Expect = 7e-12
Identities = 210/1051 (19%), Positives = 427/1051 (40%), Gaps = 142/1051 (13%)
Query: 105 EMEKKGYLEMSVECKLALLKYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYW 164
++E++ + CKLA K L E D +F + EE+ + L + + ++
Sbjct: 975 KLEEEQIILEDQNCKLAKEKKLLE---DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI-- 1029
Query: 165 YQLDQDHNVRMYIEEQDDQD-GSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNS 223
D R+ EE+ Q+ + + + + +L++ +A L+AQI + ++ + +++
Sbjct: 1030 ----TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEEL 1085
Query: 224 SRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLEN-RSTANVLEETTVKKEKED 282
+E+E +K K +E E SE Q DLE+ R++ N E+ K++ +
Sbjct: 1086 QAALARVEEEAAQKNMALKK---IRELESQISELQE-DLESERASRNKAEKQ--KRDLGE 1139
Query: 283 EKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEK 342
E E +K + L+ + E + ++E + K K ++ E K A ++ + +
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILK---KTLEEEAKTHEAQIQEMRQKHSQ 1196
Query: 343 PVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGP 402
V + E++E +K++ E K T E E+ + + K+ L+ + D + K
Sbjct: 1197 AVEELAEQLEQTKRVKANLE-KAKQTLENERGELANEVKVLLQGK-----GDSEHKRKKV 1250
Query: 403 LCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDERVAPNFKTEPIET 462
+ +F + E + E K L + L + ++ +F +E+
Sbjct: 1251 EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSA--LES 1308
Query: 463 KFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEK----ETAPLRKDADSSI- 517
+ +T+E ++ E N + S+ T +K E EK E ++A ++
Sbjct: 1309 QLQDTQE----------LLQEENRQKL--SLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 518 -SVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKD 576
+ +H+Q A +++ +ME S+ E A+++ K E + + EEK
Sbjct: 1357 KQIATLHAQVADMKK----KMEDSVGCLETAEEVKRKLQ-KDLEGLSQRHEEK------- 1404
Query: 577 KRPPILECLEKLEKSK--------KTFLDKDAQRLSPIPEEVPK----STLESEKPGSPE 624
+ +KLEK+K +D D QR S E + L EK S +
Sbjct: 1405 -----VAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAK 1459
Query: 625 AAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLD 684
AE D E A EKE + +K +LE L + + EM++L
Sbjct: 1460 YAEER------DRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ---FRTEMEDLM 1510
Query: 685 NAQT---SGIEEPSETKGSMQKSKFKYKLVPEE---ETTASENTEITSERQKEGIKLTIR 738
+++ + E ++K ++++ + K EE E A+E+ ++ E + +K
Sbjct: 1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570
Query: 739 --ISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKA 796
+ R ++ + K L + ++ + E E+E+ + ++ K E A
Sbjct: 1571 RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM-DLKDLEAHIDSA 1629
Query: 797 DKKRGEGEDEVEEESTALQ---------KTDKKEIL---KKSEKDTNSKVSKVKPKGKVR 844
+K R E ++ + ++ + ++EIL K++EK S +++ +
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEEL 1689
Query: 845 WTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLPNHPE 904
R + R DE + S + EEK EA +A +E ++ + E
Sbjct: 1690 AAAERAK-RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE--EQGNTE 1746
Query: 905 LILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERA 964
LI + A L+ + +++ ++LE Q ++L V L++ E
Sbjct: 1747 LI------NDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGT 1800
Query: 965 ERRKERLVYVGISIENIIPPQEPDFSEDQEEKKKDSKKSKANLLERRSTRTRKCISYRFD 1024
+ K + + E ++ +E+ ++K+ +A + R T +
Sbjct: 1801 VKSKYKASITAL---------EAKIAQLEEQLDNETKERQAACKQVRRTEKKL------- 1844
Query: 1025 EFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRAAAAR 1084
+ + ++D+ + A+ + KD + R K + L+E +E QRA A+R
Sbjct: 1845 ---KDVLLQVDDERRNAE-----QYKDQADKASTRLKQLKRQLEEAEEE---AQRANASR 1893
Query: 1085 RKKRRRLNDLDSDSN-LDEEESEDEFKISDG 1114
RK +R L D ++ ++ E S + K+ G
Sbjct: 1894 RKLQRELEDATETADAMNREVSSLKNKLRRG 1924
Score = 36.2 bits (82), Expect = 0.23
Identities = 84/465 (18%), Positives = 183/465 (39%), Gaps = 42/465 (9%)
Query: 938 CQH-KLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSEDQEEK 996
CQH + +K+++ +Q+L+ L+++E A R+K +L V + +E EDQ K
Sbjct: 931 CQHLQAEKKKMQQNIQELEEQLEEEESA-RQKLQLEKVTTEAKLKKLEEEQIILEDQNCK 989
Query: 997 KKDSKKSKANLL---------ERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVG 1047
KK + + E +++ + + + ++E + + K+
Sbjct: 990 LAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKT 1049
Query: 1048 RGK------DISTITGHRGKDISTILDEERKENKRPQRA-------AAARRKKRRRLNDL 1094
R K D+S I+ + + K+ + Q A AA + +++ +L
Sbjct: 1050 RRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL 1109
Query: 1095 DSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSR 1154
+S + +E+ E E + ++ + E + + + DS +
Sbjct: 1110 ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTA----------AQQ 1159
Query: 1155 PMRQSRRLRRKTPKKKYSDDDEEEESE-ENSRDSESDFSDDFSDDFVETRRRRSRRNQKR 1213
+R R KK ++ + E++ + R S ++ ++ +T+R ++ + +
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAK 1219
Query: 1214 QINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRK 1273
Q E E K L +GK HKR+ ++ +E + K +E + + E V K
Sbjct: 1220 QTLENERGELANEVKVLLQGKGDSE-HKRKKVEAQLQELQV-KFNEGERVRTELADKVTK 1277
Query: 1274 RGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSE 1333
D + + + + K + K +E+ +++ + + Q S +
Sbjct: 1278 LQVELDNVTGLLSQSDSKSSKLT-KDFSALESQLQDTQELLQEENRQKLSLSTKL---KQ 1333
Query: 1334 QESTKKPYRIESDEEEDFE-NVGKVGSPLDYSLVDLPSTNGQSPG 1377
E K +R + +EEE+ + N+ K + L + D+ S G
Sbjct: 1334 VEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVG 1378
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.125 0.342
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,686,352
Number of Sequences: 37866
Number of extensions: 3457615
Number of successful extensions: 49166
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 532
Number of HSP's successfully gapped in prelim test: 1593
Number of HSP's that attempted gapping in prelim test: 17259
Number of HSP's gapped (non-prelim): 19158
length of query: 1441
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1326
effective length of database: 13,892,928
effective search space: 18422022528
effective search space used: 18422022528
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.