Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 38348282
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38348282 RUN and FYVE domain containing 4 [Homo sapiens]
(398 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38348282 RUN and FYVE domain containing 4 [Homo sapiens] 803 0.0
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 70 4e-12
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 59 6e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 59 1e-08
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 57 3e-08
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 57 3e-08
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 57 3e-08
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 55 1e-07
gi|221139761 zinc finger protein 853 [Homo sapiens] 55 1e-07
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 54 2e-07
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 52 1e-06
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 52 1e-06
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 52 1e-06
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 52 1e-06
gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo sapi... 52 1e-06
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 51 2e-06
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 50 3e-06
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 50 3e-06
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 50 4e-06
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 49 6e-06
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 49 6e-06
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 49 6e-06
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 49 6e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 49 6e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 49 6e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 49 6e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 49 6e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 49 6e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 49 6e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 49 6e-06
>gi|38348282 RUN and FYVE domain containing 4 [Homo sapiens]
Length = 398
Score = 803 bits (2074), Expect = 0.0
Identities = 398/398 (100%), Positives = 398/398 (100%)
Query: 1 MFSESRCSSSTQTQGRRPRKNKDAPKKIPAAYGGPENVQIEDSHTSQAICLQDAPSGQQL 60
MFSESRCSSSTQTQGRRPRKNKDAPKKIPAAYGGPENVQIEDSHTSQAICLQDAPSGQQL
Sbjct: 1 MFSESRCSSSTQTQGRRPRKNKDAPKKIPAAYGGPENVQIEDSHTSQAICLQDAPSGQQL 60
Query: 61 AGLPRSQQQRHLPFFLEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTP 120
AGLPRSQQQRHLPFFLEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTP
Sbjct: 61 AGLPRSQQQRHLPFFLEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTP 120
Query: 121 STQGQGKGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGA 180
STQGQGKGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGA
Sbjct: 121 STQGQGKGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGA 180
Query: 181 VEGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQD 240
VEGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQD
Sbjct: 181 VEGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQD 240
Query: 241 EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER 300
EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER
Sbjct: 241 EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER 300
Query: 301 RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRFSR 360
RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRFSR
Sbjct: 301 RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRFSR 360
Query: 361 RYPCRLCGGLLCHACSMDYKKRDRCCPPCAQGREAQVT 398
RYPCRLCGGLLCHACSMDYKKRDRCCPPCAQGREAQVT
Sbjct: 361 RYPCRLCGGLLCHACSMDYKKRDRCCPPCAQGREAQVT 398
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 69.7 bits (169), Expect = 4e-12
Identities = 49/162 (30%), Positives = 80/162 (49%), Gaps = 27/162 (16%)
Query: 256 AQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQ----QEAERRDAMYQEELGG 311
A+ Q +LR+ + E ALRE L R Q+E + ++++ QE R+ Q+ L
Sbjct: 1068 AECQAAMLRKDK-EGAALREDLERTQKELEKATTKIQEYYNKLCQEVTNRERNDQKMLAD 1126
Query: 312 QRDLVQAMK---RRVLELIQEKDRLWQR---LQHLSSMAPE----------CCVACSKIF 355
DL + K R++EL+++KD LWQ+ L+ ++ E C+ C + F
Sbjct: 1127 LDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAEERWLGDTEANHCLDCKREF 1186
Query: 356 GRFSRRYPCRLCGGLLCHACSMDY------KKRDRCCPPCAQ 391
RR+ CR+CG + C+ C +Y K++RCC C Q
Sbjct: 1187 SWMVRRHHCRICGRIFCYYCCNNYVLSKHGGKKERCCRACFQ 1228
Score = 46.2 bits (108), Expect = 5e-05
Identities = 35/125 (28%), Positives = 68/125 (54%), Gaps = 12/125 (9%)
Query: 196 SILGEPWVLQG--HATKED-STVENPQVQTEVTLVARREEQAEVS-LQDEIKSLRLGLRK 251
+++G +L+G A + D ++ + + +L + EQA + L D++++ L +RK
Sbjct: 627 NVVGRNQLLEGKLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRK 686
Query: 252 AEE----QAQRQEQLLREQEGELQALREQLSRCQE----ERAELQAQLEQKQQEAERRDA 303
A+E Q +E +L+ +EGE Q LRE++ +CQ+ EL+A Q QQ+ + +
Sbjct: 687 AKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEV 746
Query: 304 MYQEE 308
+ E+
Sbjct: 747 LTAEK 751
Score = 43.1 bits (100), Expect = 4e-04
Identities = 48/195 (24%), Positives = 82/195 (42%), Gaps = 14/195 (7%)
Query: 163 EAEWSHVQRL------LMPSPRGAVEGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVE 216
E VQRL L R A++ Q S ++L E L +++ +
Sbjct: 779 EVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALN 838
Query: 217 NPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQ 276
VQ E+ + RE + DE + LR +E+ + + E + E L+EQ
Sbjct: 839 RAHVQ-ELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQ 897
Query: 277 LSRCQEERAELQAQ---LEQKQQEAERRDAMYQEELGGQRDLV----QAMKRRVLELIQE 329
L R + AEL Q L +++ E A +EL ++ + ++R+V L QE
Sbjct: 898 LHRANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQE 957
Query: 330 KDRLWQRLQHLSSMA 344
K+ L ++L+ + A
Sbjct: 958 KESLQEKLKAAKAAA 972
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/165 (26%), Positives = 72/165 (43%), Gaps = 19/165 (11%)
Query: 204 LQGHATKEDSTVENPQVQTE-VTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQL 262
L+ TK + Q E + + +E A SL+ +K + + + Q +QL
Sbjct: 410 LERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQL 469
Query: 263 LREQEGELQALREQLSRCQEERAELQAQLEQKQQEAE----------RRDAMYQEELGGQ 312
R LQ L S +EE AEL+ + +Q+Q+E E R+ + +L
Sbjct: 470 WRR----LQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQV 525
Query: 313 RDLVQAMKRRVLELIQEKDRLWQRLQHLSSMA----PECCVACSK 353
V ++ + +LIQ+KD L Q++ L +A PE VA K
Sbjct: 526 SQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEK 570
Score = 41.6 bits (96), Expect = 0.001
Identities = 50/214 (23%), Positives = 88/214 (41%), Gaps = 36/214 (16%)
Query: 140 EAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQGSGGSSILG 199
E V LVAE Q+ E T + +Q L GA E S+L
Sbjct: 286 EDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESML- 344
Query: 200 EPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQ-------------DEIKSLR 246
+P + AT++ +N + + +A +++A+ + E++ L
Sbjct: 345 QPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELG 404
Query: 247 LGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQ 306
L+ E + + E++ R+Q +L+ L ++L ++ RA L+ +++ A Q
Sbjct: 405 EKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEM--------APLQ 456
Query: 307 EELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHL 340
EEL G+ QE D+LW+RLQ L
Sbjct: 457 EELSGKG--------------QEADQLWRRLQEL 476
Score = 34.7 bits (78), Expect = 0.16
Identities = 30/110 (27%), Positives = 51/110 (46%), Gaps = 9/110 (8%)
Query: 235 EVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQ---AQL 291
E S ++E++ L K + + QLL EG+LQAL+ Q+ + +Q A L
Sbjct: 607 EGSQEEELRQANRELEKELQNVVGRNQLL---EGKLQALQADYQALQQRESAIQGSLASL 663
Query: 292 EQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE---LIQEKDRLWQRLQ 338
E +Q + L R +AMK ++ E ++Q K+ Q+L+
Sbjct: 664 EAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQQLR 713
Score = 34.3 bits (77), Expect = 0.20
Identities = 36/160 (22%), Positives = 68/160 (42%), Gaps = 19/160 (11%)
Query: 167 SHVQRLLMPSPR-GAVEGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEV- 224
+HVQ LL S R GA++ + Q + + Q + E++ +E+ ++Q ++
Sbjct: 840 AHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLH 899
Query: 225 ----------------TLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEG 268
T+ R E+A E++ + + E +RQ L++++
Sbjct: 900 RANTDTAELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKE 959
Query: 269 ELQALREQLSRCQEERAELQAQLEQKQQEAER-RDAMYQE 307
LQ + LQAQL Q +Q A+ ++A +QE
Sbjct: 960 SLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQE 999
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 59.3 bits (142), Expect = 6e-09
Identities = 47/222 (21%), Positives = 110/222 (49%), Gaps = 13/222 (5%)
Query: 123 QGQGKGAMGTQKEVIGMEAEVTGVLLVAEGQ-RTTEGTHKKEAEWSHVQRLLMPSPRGAV 181
+GQ + G +E G E G + EGQ R EG +++ Q + G V
Sbjct: 128 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 187
Query: 182 ---EGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSL 238
EG + G ++G +GE G ++ E + E + R++E+
Sbjct: 188 REQEGQM-GEQEGQ-----MGEQEEQMGEQEEQMQKQEEQMGEQEEQM--RKQEEQMGEQ 239
Query: 239 QDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEA 298
+++++ ++K EEQ ++QE+ +REQE +++ EQ+ + Q+E+ E + Q +++++
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLK-QKEQTEQEEQTGEQEEQM 298
Query: 299 ERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHL 340
++ +E+ R+ + M+ + ++ ++++++W++ + +
Sbjct: 299 REQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQM 340
Score = 47.4 bits (111), Expect = 2e-05
Identities = 34/217 (15%), Positives = 100/217 (46%), Gaps = 1/217 (0%)
Query: 124 GQGKGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEG 183
G+ +G MG Q+E +G + E G++ E K+E + + + +
Sbjct: 195 GEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQE-EQMRKQEEQMGEQEEQVQKQEEQVQKQ 253
Query: 184 AVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIK 243
+Q + + K+ E + E R +E+ +++++
Sbjct: 254 EEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMR 313
Query: 244 SLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDA 303
+R+ EEQ +QE+ + EQ+ ++ +EQ+ + +E+ E + Q+++++++ +++
Sbjct: 314 EQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373
Query: 304 MYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHL 340
+++ R + M+++ ++ ++K+++ ++ + +
Sbjct: 374 QMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQM 410
Score = 47.4 bits (111), Expect = 2e-05
Identities = 26/100 (26%), Positives = 58/100 (58%), Gaps = 2/100 (2%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
KE + Q+ + + +EEQ + +++++ +RK EEQ ++QE+ +R+QE +
Sbjct: 337 KEQMWEQKEQMWKQEEQMGEQEEQMQKQ-EEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQ 395
Query: 270 LQALREQLSRCQEERAELQAQL-EQKQQEAERRDAMYQEE 308
+ +EQ+ +E+ E + Q+ EQK+Q ++ + M +++
Sbjct: 396 MGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQK 435
Score = 45.4 bits (106), Expect = 9e-05
Identities = 23/76 (30%), Positives = 50/76 (65%), Gaps = 3/76 (3%)
Query: 253 EEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQL-EQKQQEAERRDAM--YQEEL 309
EEQ Q+QE+ +R+QE +++ EQ+ + +E+ + + Q+ EQK+Q E+++ M +E++
Sbjct: 358 EEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQM 417
Query: 310 GGQRDLVQAMKRRVLE 325
G Q++ ++ + + E
Sbjct: 418 GEQKEQMRKQEEHMGE 433
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/135 (22%), Positives = 73/135 (54%), Gaps = 8/135 (5%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
+E+ E + E R +E+ ++++ + + + +EQ +QE+ + EQE +
Sbjct: 301 QEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQ 360
Query: 270 LQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE---- 325
+Q EQ+ R QEE+ Q + +KQ+E R+ +E++G Q++ + K ++ E
Sbjct: 361 MQKQEEQV-RKQEEQMRKQEEQMRKQEEQMRKQ---EEQMGEQKEQMGEQKEQMREQEEQ 416
Query: 326 LIQEKDRLWQRLQHL 340
+ ++K+++ ++ +H+
Sbjct: 417 MGEQKEQMRKQEEHM 431
Score = 43.5 bits (101), Expect = 3e-04
Identities = 30/126 (23%), Positives = 66/126 (52%), Gaps = 6/126 (4%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQD-EIKSLRLGLRKAEEQAQRQEQLL 263
+G +++ V + Q RE++ +V Q+ +++ +R+ E Q + QE +
Sbjct: 100 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 159
Query: 264 REQEGELQ----ALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAM 319
REQEG+++ +REQ + +E+ +++ Q E + E E + +E++G Q + +Q
Sbjct: 160 REQEGQVREQEGQVREQEGQVREQEGQVREQ-EGQMGEQEGQMGEQEEQMGEQEEQMQKQ 218
Query: 320 KRRVLE 325
+ ++ E
Sbjct: 219 EEQMGE 224
Score = 43.1 bits (100), Expect = 4e-04
Identities = 40/212 (18%), Positives = 100/212 (47%), Gaps = 4/212 (1%)
Query: 132 TQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPR-GAVEGAVSGSRQ 190
T +E+ AE+ L + E +++ H KE + ++ +P P+ G V R+
Sbjct: 5 TNEELKEKNAELQEELQLVETEKSEIQLHIKELK-RKLETDKIPLPQEGQVREQEGQVRE 63
Query: 191 GSGG-SSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQD-EIKSLRLG 248
G G+ +G +++ V + Q RE++ +V Q+ +++
Sbjct: 64 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 123
Query: 249 LRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEE 308
+R+ E Q + QE +REQEG+++ Q+ + + E + Q+ +++ + ++ +E+
Sbjct: 124 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 183
Query: 309 LGGQRDLVQAMKRRVLELIQEKDRLWQRLQHL 340
G R+ M + ++ ++++++ ++ + +
Sbjct: 184 EGQVREQEGQMGEQEGQMGEQEEQMGEQEEQM 215
Score = 35.4 bits (80), Expect = 0.091
Identities = 22/90 (24%), Positives = 48/90 (53%), Gaps = 4/90 (4%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
+E + Q+Q + V ++EEQ +++++ +RK EEQ Q++ + EQ+
Sbjct: 351 EEQMGEQEEQMQKQEEQVRKQEEQMRKQ-EEQMRKQEEQMRKQEEQMGEQKEQMGEQK-- 407
Query: 270 LQALREQLSRCQEERAELQAQLEQKQQEAE 299
+ +REQ + E++ +++ Q E ++ E
Sbjct: 408 -EQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 58.5 bits (140), Expect = 1e-08
Identities = 53/216 (24%), Positives = 85/216 (39%), Gaps = 36/216 (16%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
K + + QV+ E + + + E L EIK +G++K EE + +
Sbjct: 1190 KRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNEN 1249
Query: 270 LQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDL----------VQAM 319
L ++++ Q +EL+ Q + + E +A Q +R L ++ +
Sbjct: 1250 LGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL 1309
Query: 320 KRRVLEL----------IQEKDRLWQRLQHLSSMA----------PECCVACSKIFGRFS 359
+ +VLEL +QE R Q LQ + A + C+AC K F
Sbjct: 1310 QTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTV 1369
Query: 360 RRYPCRLCGGLLCHACSM------DYKKRDRCCPPC 389
RR+ CR CG + C CS KK R C C
Sbjct: 1370 RRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDAC 1405
Score = 43.9 bits (102), Expect = 3e-04
Identities = 34/137 (24%), Positives = 65/137 (47%), Gaps = 1/137 (0%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
+E+ Q+Q+E+ + + + E L + L+ + + E+ +EQ + + + +
Sbjct: 402 REEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLK 461
Query: 270 LQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQE 329
L L EQL ELQ QL++ +Q+ + + A+ Q R+ Q +VL I +
Sbjct: 462 LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE-AQNDLEQVLRQIGD 520
Query: 330 KDRLWQRLQHLSSMAPE 346
KD+ Q L+ L + E
Sbjct: 521 KDQKIQNLEALLQKSKE 537
Score = 40.4 bits (93), Expect = 0.003
Identities = 40/166 (24%), Positives = 75/166 (45%), Gaps = 28/166 (16%)
Query: 186 SGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDE---I 242
+G+ G GG S L A K D +VTL+ + + + SL++E
Sbjct: 66 AGNDSGHGGESNL---------ALKRD----------DVTLLRQEVQDLQASLKEEKWYS 106
Query: 243 KSLRLGLRK---AEEQAQRQEQLLREQEGELQALREQLSRCQEER---AELQAQLEQKQQ 296
+ L+ L K ++Q + + L+ + ELQ+L +QL Q E +++ EQK
Sbjct: 107 EELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAA 166
Query: 297 EAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSS 342
+ A + + +R L +A +++V L +E ++ +Q L +
Sbjct: 167 QLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKT 212
Score = 38.5 bits (88), Expect = 0.011
Identities = 30/116 (25%), Positives = 58/116 (50%), Gaps = 4/116 (3%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIK-SLRLGLRKAEEQAQRQEQLLREQEGELQALREQL 277
QVQ E TL ++E + + + E L+L L +EQ + + L++ E E Q L+ +
Sbjct: 902 QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
Query: 278 SRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
+ ++ + + Q+E Q E + + + EL + L Q + + EL EK+++
Sbjct: 962 NELKQSSEQKKKQIEALQGEL-KIAVLQKTEL--ENKLQQQLTQAAQELAAEKEKI 1014
Score = 38.1 bits (87), Expect = 0.014
Identities = 36/160 (22%), Positives = 69/160 (43%), Gaps = 24/160 (15%)
Query: 203 VLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQL 262
++Q T + + E Q+Q + + + EQ + ++ L++ + + E + +Q
Sbjct: 940 LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 263 LREQEGELQALREQLS-------RCQEERAELQAQLEQKQQE--AERRDAMYQEE----- 308
L + EL A +E++S + QE +LQ+ ++ E A R+D EE
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
Query: 309 ----------LGGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
+G Q L+Q +K L Q+ + Q+LQ
Sbjct: 1060 QEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099
Score = 36.2 bits (82), Expect = 0.053
Identities = 40/160 (25%), Positives = 70/160 (43%), Gaps = 36/160 (22%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
KE V E+ + R+E+ L +E+KS +L K + +QLL +Q+ E
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 270 LQA------------------LREQLSRCQEE--------RAELQAQLEQKQ------QE 297
LQ L++Q+ + +EE A+L +++++K+ +E
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234
Query: 298 AERRDAM----YQEELGGQRDLVQAMKRRVLELIQEKDRL 333
E + M E LG + Q+ +RRV EL ++ D L
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1274
Score = 35.8 bits (81), Expect = 0.070
Identities = 35/158 (22%), Positives = 73/158 (46%), Gaps = 22/158 (13%)
Query: 204 LQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDE---IKSLRLGLRKAEEQAQRQE 260
LQ H + +++ Q E+ + + +Q LQD+ L L++ +E+ E
Sbjct: 665 LQNHLDTAQNALQDKQ--QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE 722
Query: 261 QLLREQEG----------ELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQE--- 307
Q E EG E++A +EQ + +++ +L LE + E ++ M +E
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
Query: 308 ----ELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
+L + + ++++K+++ + +EK L Q + LS
Sbjct: 783 STRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820
Score = 35.4 bits (80), Expect = 0.091
Identities = 40/185 (21%), Positives = 78/185 (42%), Gaps = 4/185 (2%)
Query: 154 RTTEGTHKKEAEWSHVQ--RLLMPSPRGAVEGAVSGSRQGSGGSSILGEPWVLQGHATKE 211
R TE + + E E V RL + A+E + IL + + TK
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKI 825
Query: 212 DSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQE-QLLREQEGEL 270
N ++QT VT + + + + E +L E+ +++ L K + + + + +E +
Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKE-ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGK 884
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEK 330
A+ + C+E + +LQ Q+E +E + ++E L + +LIQ +
Sbjct: 885 AAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 944
Query: 331 DRLWQ 335
+ L Q
Sbjct: 945 NTLKQ 949
Score = 34.7 bits (78), Expect = 0.16
Identities = 29/122 (23%), Positives = 55/122 (45%), Gaps = 7/122 (5%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQ--RQEQLLREQE-----GELQ 271
QVQT + + E+ L+DE K L+ +E R E QE ELQ
Sbjct: 232 QVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQ 291
Query: 272 ALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
L+ ++ ++ L L +K+Q+ + + + EE ++++ + ++ L+ Q +
Sbjct: 292 KLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQS 351
Query: 332 RL 333
RL
Sbjct: 352 RL 353
Score = 33.9 bits (76), Expect = 0.27
Identities = 30/121 (24%), Positives = 60/121 (49%), Gaps = 5/121 (4%)
Query: 227 VARREEQAEVSLQD-EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERA 285
V+++ QA + +D + + L+ L +E R L E+ Q L+E+LS + +
Sbjct: 330 VSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQ 389
Query: 286 ELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAP 345
L+A+ +Q QQ+ E ++ Q L Q ++ Q + ++LE ++ RL+ ++
Sbjct: 390 HLKAEFKQLQQQREEKE---QHGLQLQSEINQ-LHSKLLETERQLGEAHGRLKEQRQLSS 445
Query: 346 E 346
E
Sbjct: 446 E 446
Score = 33.9 bits (76), Expect = 0.27
Identities = 29/149 (19%), Positives = 74/149 (49%), Gaps = 7/149 (4%)
Query: 191 GSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLR 250
G G +++L + + H +E T Q+ ++ + +QA+ +L D+++ + LR
Sbjct: 556 GEGETAVLNQLQE-KNHTLQEQVT----QLTEKLKNQSESHKQAQENLHDQVQEQKAHLR 610
Query: 251 KAEEQAQRQEQLLREQEGELQALREQLSRCQ-EERAELQAQLEQKQQEAERRDAMYQEEL 309
A+++ E + E +L +E++S+ + +A+ + L + + +R A Q L
Sbjct: 611 AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQR-ADLQNHL 669
Query: 310 GGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
++ +Q ++ + ++ + D++ +LQ
Sbjct: 670 DTAQNALQDKQQELNKITTQLDQVTAKLQ 698
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 57.0 bits (136), Expect = 3e-08
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 21/162 (12%)
Query: 237 SLQDEIKS---LRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQ 293
SL+ E+KS R L++ + + LLR + +++ L+++L Q+E+AELQ E+
Sbjct: 438 SLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEE 497
Query: 294 KQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSK 353
++Q +E+G L + + +E I+E ++ + L C C K
Sbjct: 498 QEQAL--------QEMG----LHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEK 545
Query: 354 IFGRFSRRYPCRLCGGLLCHACSMD------YKKRDRCCPPC 389
F R++ CR CG + C+ CS + Y K R C C
Sbjct: 546 EFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSC 587
Score = 35.4 bits (80), Expect = 0.091
Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 25/140 (17%)
Query: 215 VENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGL----RKAEEQAQRQEQLLREQEGEL 270
+E + + TLVA R++ +E+K++ L + + AE Q++ + + EG+
Sbjct: 330 LEKDTHEKQDTLVALRQQL------EEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKT 383
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQ-----------AM 319
+ + + EER + E+ +Q AE R Q+ELGG+ +Q ++
Sbjct: 384 NQVMSSMKQ-MEERLQ---HSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSL 439
Query: 320 KRRVLELIQEKDRLWQRLQH 339
++ + +++ L + LQH
Sbjct: 440 EKELKSEKEQRQALQRELQH 459
Score = 32.3 bits (72), Expect = 0.77
Identities = 35/147 (23%), Positives = 63/147 (42%), Gaps = 13/147 (8%)
Query: 210 KEDSTVENPQVQTEVTLVA----RREEQAEVSLQDE---IKSLRLGLRKAEEQAQRQEQL 262
K+D+ V Q EV + + + AE SLQ + I S + ++ E+
Sbjct: 337 KQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER 396
Query: 263 LREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRR 322
L+ E Q E+ + Q+E L+ + + + + ++EL +++ QA++R
Sbjct: 397 LQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQR- 455
Query: 323 VLELIQEKDR---LWQRLQHLSSMAPE 346
EL EKD L LQ + + E
Sbjct: 456 --ELQHEKDTSSLLRMELQQVEGLKKE 480
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 57.0 bits (136), Expect = 3e-08
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 21/162 (12%)
Query: 237 SLQDEIKS---LRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQ 293
SL+ E+KS R L++ + + LLR + +++ L+++L Q+E+AELQ E+
Sbjct: 438 SLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEE 497
Query: 294 KQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSK 353
++Q +E+G L + + +E I+E ++ + L C C K
Sbjct: 498 QEQAL--------QEMG----LHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEK 545
Query: 354 IFGRFSRRYPCRLCGGLLCHACSMD------YKKRDRCCPPC 389
F R++ CR CG + C+ CS + Y K R C C
Sbjct: 546 EFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSC 587
Score = 35.4 bits (80), Expect = 0.091
Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 25/140 (17%)
Query: 215 VENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGL----RKAEEQAQRQEQLLREQEGEL 270
+E + + TLVA R++ +E+K++ L + + AE Q++ + + EG+
Sbjct: 330 LEKDTHEKQDTLVALRQQL------EEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKT 383
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQ-----------AM 319
+ + + EER + E+ +Q AE R Q+ELGG+ +Q ++
Sbjct: 384 NQVMSSMKQ-MEERLQ---HSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSL 439
Query: 320 KRRVLELIQEKDRLWQRLQH 339
++ + +++ L + LQH
Sbjct: 440 EKELKSEKEQRQALQRELQH 459
Score = 32.3 bits (72), Expect = 0.77
Identities = 35/147 (23%), Positives = 63/147 (42%), Gaps = 13/147 (8%)
Query: 210 KEDSTVENPQVQTEVTLVA----RREEQAEVSLQDE---IKSLRLGLRKAEEQAQRQEQL 262
K+D+ V Q EV + + + AE SLQ + I S + ++ E+
Sbjct: 337 KQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER 396
Query: 263 LREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRR 322
L+ E Q E+ + Q+E L+ + + + + ++EL +++ QA++R
Sbjct: 397 LQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQR- 455
Query: 323 VLELIQEKDR---LWQRLQHLSSMAPE 346
EL EKD L LQ + + E
Sbjct: 456 --ELQHEKDTSSLLRMELQQVEGLKKE 480
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 57.0 bits (136), Expect = 3e-08
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 21/162 (12%)
Query: 237 SLQDEIKS---LRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQ 293
SL+ E+KS R L++ + + LLR + +++ L+++L Q+E+AELQ E+
Sbjct: 546 SLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEE 605
Query: 294 KQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSK 353
++Q +E+G L + + +E I+E ++ + L C C K
Sbjct: 606 QEQAL--------QEMG----LHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEK 653
Query: 354 IFGRFSRRYPCRLCGGLLCHACSMD------YKKRDRCCPPC 389
F R++ CR CG + C+ CS + Y K R C C
Sbjct: 654 EFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSC 695
Score = 35.4 bits (80), Expect = 0.091
Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 25/140 (17%)
Query: 215 VENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGL----RKAEEQAQRQEQLLREQEGEL 270
+E + + TLVA R++ +E+K++ L + + AE Q++ + + EG+
Sbjct: 438 LEKDTHEKQDTLVALRQQL------EEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKT 491
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQ-----------AM 319
+ + + EER + E+ +Q AE R Q+ELGG+ +Q ++
Sbjct: 492 NQVMSSMKQ-MEERLQ---HSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSL 547
Query: 320 KRRVLELIQEKDRLWQRLQH 339
++ + +++ L + LQH
Sbjct: 548 EKELKSEKEQRQALQRELQH 567
Score = 32.3 bits (72), Expect = 0.77
Identities = 35/147 (23%), Positives = 63/147 (42%), Gaps = 13/147 (8%)
Query: 210 KEDSTVENPQVQTEVTLVA----RREEQAEVSLQDE---IKSLRLGLRKAEEQAQRQEQL 262
K+D+ V Q EV + + + AE SLQ + I S + ++ E+
Sbjct: 445 KQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEER 504
Query: 263 LREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRR 322
L+ E Q E+ + Q+E L+ + + + + ++EL +++ QA++R
Sbjct: 505 LQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQR- 563
Query: 323 VLELIQEKDR---LWQRLQHLSSMAPE 346
EL EKD L LQ + + E
Sbjct: 564 --ELQHEKDTSSLLRMELQQVEGLKKE 588
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 55.1 bits (131), Expect = 1e-07
Identities = 43/127 (33%), Positives = 73/127 (57%), Gaps = 15/127 (11%)
Query: 218 PQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQL 277
PQVQT TL Q E + E K +RK EE+ RQE+ LREQEG+++ E++
Sbjct: 263 PQVQTN-TLQEEMWRQEEELREQEKK-----IRKQEEKMWRQEERLREQEGKMREQEEKM 316
Query: 278 SRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE----LIQEKDRL 333
R QE+R Q + E ++QE E R+ Q+EL Q + +Q + ++ E + ++++++
Sbjct: 317 WR-QEKRLREQ-EKELREQEKELRE---QKELREQEEQMQEQEEKMWEQEEKMREQEEKM 371
Query: 334 WQRLQHL 340
W++ + L
Sbjct: 372 WRQEERL 378
Score = 48.1 bits (113), Expect = 1e-05
Identities = 32/111 (28%), Positives = 65/111 (58%), Gaps = 8/111 (7%)
Query: 230 REEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQA 289
RE++ E+ Q++ + LR+ EEQ Q QE+ + EQE +++ E++ R +E E +
Sbjct: 324 REQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 383
Query: 290 QLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHL 340
Q+ ++QE + RD QEE ++D R E ++E++++W++++ +
Sbjct: 384 QM--REQEQKMRD---QEERMWEQD---ERLREKEERMREQEKMWEQVEKM 426
Score = 44.3 bits (103), Expect = 2e-04
Identities = 30/142 (21%), Positives = 74/142 (52%), Gaps = 7/142 (4%)
Query: 202 WVLQGHATKEDSTVENPQVQTEVTLVARREE----QAEVSLQDEIKSLRLGLRKAEEQAQ 257
W Q +++ E ++Q + + +EE Q E+ Q++ + +R+ E+Q
Sbjct: 488 WQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW 547
Query: 258 RQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER---RDAMYQEELGGQRD 314
QE+ +R+QE ++ E++ + +E+ + E+K +E ER R+ +EE R+
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 607
Query: 315 LVQAMKRRVLELIQEKDRLWQR 336
+ M+ + ++ ++++++W++
Sbjct: 608 QEEKMQEQEEKMQEQEEKMWEQ 629
Score = 44.3 bits (103), Expect = 2e-04
Identities = 28/106 (26%), Positives = 61/106 (57%), Gaps = 8/106 (7%)
Query: 230 REEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQA 289
+E++ + Q+E +R+ E++ + +E+++REQE ++Q EQ + QE+ ++
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ---EQEEKMQEQEEKMWE 628
Query: 290 QLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQ 335
Q E+K QE E + +E++ Q + + +R L ++K++LW+
Sbjct: 629 Q-EEKMQEQEEKMWEQEEKMWEQEEKMWEQQR----LPEQKEKLWE 669
Score = 43.5 bits (101), Expect = 3e-04
Identities = 30/135 (22%), Positives = 70/135 (51%), Gaps = 10/135 (7%)
Query: 202 WVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQ 261
W + +E + ++ + + + +EQ + + E +R+ E++ + +E+
Sbjct: 668 WEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEE 727
Query: 262 LLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKR 321
++REQE ++Q EQ + QE+ E+ EQ+++ E+ + M+++ QR Q K
Sbjct: 728 MMREQEEKMQ---EQEEKMQEQEEEM---WEQEEKMWEQEEKMWEQ----QRLPEQKEKL 777
Query: 322 RVLELIQEKDRLWQR 336
E +QE++++W++
Sbjct: 778 WEHEKMQEQEKIWEQ 792
Score = 41.6 bits (96), Expect = 0.001
Identities = 34/111 (30%), Positives = 63/111 (56%), Gaps = 11/111 (9%)
Query: 231 EEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERA-ELQA 289
+EQ E + E K +R+ EE+ RQE+ L EQE +++ +EQ R QEER E
Sbjct: 351 QEQEEKMWEQEEK-----MREQEEKMWRQEERLWEQEKQMRE-QEQKMRDQEERMWEQDE 404
Query: 290 QLEQKQQEAERRDAMYQ--EELGGQRDLVQAMK--RRVLELIQEKDRLWQR 336
+L +K++ ++ M++ E++ ++ + + K R E +QE++R+ +R
Sbjct: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER 455
Score = 41.6 bits (96), Expect = 0.001
Identities = 24/94 (25%), Positives = 51/94 (54%)
Query: 230 REEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQA 289
REE++ + +++ +R+ EE+ Q QE+ ++EQE E+ E++ +E+ E Q
Sbjct: 710 REEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769
Query: 290 QLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRV 323
EQK++ E QE++ Q + ++ + ++
Sbjct: 770 LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM 803
Score = 40.0 bits (92), Expect = 0.004
Identities = 26/117 (22%), Positives = 62/117 (52%), Gaps = 10/117 (8%)
Query: 230 REEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQA 289
+E++ + Q+E +R+ E++ + +E+ +REQE ++Q E + +E+ + Q
Sbjct: 433 QEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 492
Query: 290 QLEQKQ--------QEAERRDAMYQEELGGQRDLVQAMKR--RVLELIQEKDRLWQR 336
EQK+ QE E + +E++ Q ++ K+ R ++ +++D++W++
Sbjct: 493 LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549
Score = 39.7 bits (91), Expect = 0.005
Identities = 22/108 (20%), Positives = 55/108 (50%)
Query: 229 RREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQ 288
R EE+ +++++ +++ EE+ QE+ ++EQE ++ E++ +E+ E Q
Sbjct: 599 REEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQ 658
Query: 289 AQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQR 336
EQK++ E QE++ Q + + ++ + +++ + W +
Sbjct: 659 RLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQ 706
Score = 38.9 bits (89), Expect = 0.008
Identities = 37/146 (25%), Positives = 74/146 (50%), Gaps = 20/146 (13%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQA----EVSLQDEIKSLRLGLRKAEEQAQR---QEQL 262
+E+ E + E R +E+ E L ++ K +R +K +Q +R Q++
Sbjct: 346 QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDER 405
Query: 263 LREQE---GELQALREQLSRCQEERAELQAQ------LEQKQQEAER---RDAMYQEELG 310
LRE+E E + + EQ+ + +EE+ ++Q Q E+K QE ER R+ +EE
Sbjct: 406 LREKEERMREQEKMWEQVEKMREEK-KMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
Query: 311 GQRDLVQAMKRRVLELIQEKDRLWQR 336
R+ + M+++ + +++++ WQ+
Sbjct: 465 TMREQEEKMQKQEENMWEQEEKEWQQ 490
Score = 38.1 bits (87), Expect = 0.014
Identities = 27/114 (23%), Positives = 61/114 (53%), Gaps = 8/114 (7%)
Query: 229 RREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQA---LREQLSRCQEERA 285
R E+ E + E ++ + E++ Q QE+ R+QE ++Q +RE+ + +EE
Sbjct: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
Query: 286 ELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE---LIQEKDRLWQR 336
++ Q E+ Q++ E + QEE Q+ + K ++ E + ++++++W++
Sbjct: 465 TMREQEEKMQKQEE--NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 516
Score = 38.1 bits (87), Expect = 0.014
Identities = 39/259 (15%), Positives = 106/259 (40%), Gaps = 33/259 (12%)
Query: 65 RSQQQRHLPFFLEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQG 124
R +Q+ + EK E + + +WE E E + ++E+ W + + +
Sbjct: 659 RLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER 718
Query: 125 QGKGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGA 184
+ K M ++E++ + E ++ E ++E W +++
Sbjct: 719 EKK--MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM------------ 764
Query: 185 VSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKS 244
W Q +++ E+ ++Q + + + E+ + +++++
Sbjct: 765 -----------------WEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ--EEKMRG 805
Query: 245 LRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAM 304
+R EE+ + QE+ + QE ++ E++ +E+ + ++E+K Q E +
Sbjct: 806 QEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMRE 865
Query: 305 YQEELGGQRDLVQAMKRRV 323
+E++ GQ + ++ + ++
Sbjct: 866 QEEKMRGQEEKMREQEEKM 884
Score = 38.1 bits (87), Expect = 0.014
Identities = 31/122 (25%), Positives = 62/122 (50%), Gaps = 16/122 (13%)
Query: 229 RREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQL---LREQE---------GELQALREQ 276
R EQ E + E + +++ EE+ QE++ +EQE E +++RE+
Sbjct: 659 RLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRER 718
Query: 277 LSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE---LIQEKDRL 333
+ +EE E+ + E+K QE E + +EE+ Q + + + ++ E L ++K++L
Sbjct: 719 EKKMREEE-EMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKL 777
Query: 334 WQ 335
W+
Sbjct: 778 WE 779
Score = 33.5 bits (75), Expect = 0.35
Identities = 51/265 (19%), Positives = 115/265 (43%), Gaps = 35/265 (13%)
Query: 77 EKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAMGTQKEV 136
E+ E +K R + M + +++Q +QEE+ E + Q Q + M Q+E
Sbjct: 589 ERMREREKKMREEEEMMREQEEKMQ-EQEEKMQEQEEKMWEQEEKMQEQEE-KMWEQEEK 646
Query: 137 IGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQGSGGSS 196
+ + E + E QR E +KE W H E +
Sbjct: 647 MWEQEEK-----MWEQQRLPE---QKEKLWEH-------------EKMQEQEKMQEQEEK 685
Query: 197 ILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQA 256
I + + + +E T + +++ E ++ R ++ E ++ ++ +++ EE+
Sbjct: 686 IWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREE--EEMMREQEEKMQEQEEKM 743
Query: 257 QRQEQLLREQEGELQALREQL---SRCQEERAEL----QAQLEQKQQEAERRDAMYQEEL 309
Q QE+ + EQE ++ E++ R E++ +L + Q ++K E E + +E++
Sbjct: 744 QEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKM 803
Query: 310 GGQRDLVQAMKRRVLELIQEKDRLW 334
GQ + ++ + + + +++++W
Sbjct: 804 RGQEEKMRGQEEK---MRGQEEKMW 825
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 54.7 bits (130), Expect = 1e-07
Identities = 68/305 (22%), Positives = 132/305 (43%), Gaps = 29/305 (9%)
Query: 35 PENVQIEDSHTSQAICLQDAPSGQQLAGLPRSQQQRHLPFF-LEKKGESSRKHRY----P 89
P++ Q++ + Q GQQ L + QQ++H E K E H+ P
Sbjct: 104 PQHEQLQQPQPHLELQQQPQQDGQQQ--LSQLQQEKHQSVHHQELKPELQLMHQQQQLQP 161
Query: 90 QSMWEPEGKELQLDQ--EERAPWIEIFLGNSTPSTQGQGKGAMGTQKEVIGMEAEVTGVL 147
Q + E + + Q +Q ++A ++ Q Q + + Q+E + + L
Sbjct: 162 QQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQ-----L 216
Query: 148 LVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQGSGGSSILGEPWVLQGH 207
L + Q + +++ + Q+LL+ +G ++ + +Q +L +
Sbjct: 217 LQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQ 276
Query: 208 ATKEDSTVENPQVQTEVTLVARREEQAEVSLQD-----------EIKSLRLGLRKAEEQA 256
+ Q Q + L ++E+ + LQ E++ + + L +E
Sbjct: 277 QLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELE 336
Query: 257 QRQEQLLREQEGELQALREQLS-RCQEERAELQAQLEQKQQEAERRDAMYQ---EELGGQ 312
Q++++L R+QE E Q + QL + QEE +L+ QLEQ+QQ+ E+++ + ELG Q
Sbjct: 337 QQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQ 396
Query: 313 RDLVQ 317
+ VQ
Sbjct: 397 QQEVQ 401
Score = 45.8 bits (107), Expect = 7e-05
Identities = 29/131 (22%), Positives = 76/131 (58%), Gaps = 3/131 (2%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
++ +V + +++ E+ L+ ++++ +Q++ + + + +QAQ Q+ L ++++ +
Sbjct: 136 EKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQ 195
Query: 270 LQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE---L 326
Q +QL + Q+E+ + Q L+Q++Q +++ QE+L Q+ L+ ++ L+ L
Sbjct: 196 QQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLL 255
Query: 327 IQEKDRLWQRL 337
Q++ +L Q+L
Sbjct: 256 QQQQAQLQQQL 266
Score = 45.4 bits (106), Expect = 9e-05
Identities = 37/127 (29%), Positives = 69/127 (54%), Gaps = 7/127 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALRE 275
E Q Q ++ L+ ++ + + LQ + L+ L + ++QAQ Q+QLL +Q+ +LQ ++
Sbjct: 233 EQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLE-QQQAQLQQQLLLQQQEQLQQQQQ 291
Query: 276 QLSRCQEERAELQAQLEQKQQEAERRDAMYQE----ELGGQRDLVQAMKRRVLELIQEKD 331
Q Q++ Q QL+ E E + + E +LG +++L Q +R+ LE QE +
Sbjct: 292 QQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQ--QRQELERQQELE 349
Query: 332 RLWQRLQ 338
R ++ Q
Sbjct: 350 RQQEQRQ 356
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/130 (28%), Positives = 70/130 (53%), Gaps = 13/130 (10%)
Query: 219 QVQTEVTLVARREE-QAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLR-EQEGELQALREQ 276
QVQ + L ++E+ Q + LQ + + + ++ +EQ Q+Q+QLL +Q+G+LQ
Sbjct: 197 QVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQ----- 251
Query: 277 LSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQR 336
Q+ + QAQL+Q+ E ++ Q L Q L Q ++++L+ Q++++L Q+
Sbjct: 252 ----QQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQ--QQQEQLQQQ 305
Query: 337 LQHLSSMAPE 346
+ PE
Sbjct: 306 QLQPPPLEPE 315
Score = 43.1 bits (100), Expect = 4e-04
Identities = 38/135 (28%), Positives = 71/135 (52%), Gaps = 10/135 (7%)
Query: 215 VENPQVQTEVTLVARREEQAEVS-LQDEI------KSLRLGLRKAEEQAQRQEQLLREQE 267
++ PQ E+ +++ Q ++S LQ E + L+ L+ +Q Q Q Q ++EQ+
Sbjct: 109 LQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQ 168
Query: 268 GELQALREQLSRCQEERAELQAQLEQKQQEAERRDAM--YQEELGGQRDLVQAMKRRVLE 325
LQ +EQL Q + ++ Q EQ QQ+ + + + QE+L Q+ L Q + + +
Sbjct: 169 -RLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQ 227
Query: 326 LIQEKDRLWQRLQHL 340
Q++++L Q+ Q L
Sbjct: 228 FQQQQEQLQQQQQLL 242
Score = 42.0 bits (97), Expect = 0.001
Identities = 38/152 (25%), Positives = 71/152 (46%), Gaps = 17/152 (11%)
Query: 191 GSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLR 250
GSGGS E + +++ + V P +E+ R ++ L L+
Sbjct: 45 GSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQR------------ELQLQ 92
Query: 251 KAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELG 310
+ E+Q + Q+Q EQ LQ + L Q+ + + Q QL Q QQE + +++ +EL
Sbjct: 93 QLEQQPEPQQQPQHEQ---LQQPQPHLELQQQPQQDGQQQLSQLQQE--KHQSVHHQELK 147
Query: 311 GQRDLVQAMKRRVLELIQEKDRLWQRLQHLSS 342
+ L+ ++ + +QE+ RL Q+ + L +
Sbjct: 148 PELQLMHQQQQLQPQQVQEQQRLQQQQEQLQT 179
Score = 42.0 bits (97), Expect = 0.001
Identities = 32/126 (25%), Positives = 74/126 (58%), Gaps = 6/126 (4%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAE--EQAQRQEQLLREQEGELQAL 273
+ Q+Q + +R +Q + LQ + + L++ E +Q +++QLL++Q+ +LQ
Sbjct: 155 QQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQ-- 212
Query: 274 REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE--LIQEKD 331
++QL + QE+ + Q Q +Q+Q + +++ + Q++ Q+ L+Q + ++ + L Q++
Sbjct: 213 QQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQA 272
Query: 332 RLWQRL 337
+L Q+L
Sbjct: 273 QLQQQL 278
Score = 40.8 bits (94), Expect = 0.002
Identities = 29/143 (20%), Positives = 73/143 (51%), Gaps = 11/143 (7%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLR 264
Q H + ++ Q Q + + L+ E++ + + +Q Q Q++L +
Sbjct: 113 QPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQ 172
Query: 265 EQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLV-------- 316
+QE +LQ + Q + +++ +LQ Q++++Q ++++ + Q++L Q++ +
Sbjct: 173 QQE-QLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQ 231
Query: 317 --QAMKRRVLELIQEKDRLWQRL 337
Q +++ L L+Q++ +L Q+L
Sbjct: 232 QEQLQQQQQLLLLQQQGQLQQQL 254
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 54.3 bits (129), Expect = 2e-07
Identities = 42/133 (31%), Positives = 70/133 (52%), Gaps = 28/133 (21%)
Query: 218 PQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL------- 270
PQVQT TL Q E + E K +RK EE+ RQE+ LREQEG++
Sbjct: 225 PQVQTN-TLQEEMWRQEEELREQEKK-----IRKQEEKMWRQEERLREQEGKMREQEEKM 278
Query: 271 ----QALREQLSRCQEERAELQAQ---LEQKQQEAERRDAMYQEELGGQRDLVQAMKRRV 323
+ LREQ +E+ EL+ Q EQ++Q E+ + M+++E + M+ +
Sbjct: 279 RRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE--------EKMREQE 330
Query: 324 LELIQEKDRLWQR 336
++ ++++RLW++
Sbjct: 331 EKMWRQEERLWEQ 343
Score = 51.6 bits (122), Expect = 1e-06
Identities = 39/160 (24%), Positives = 76/160 (47%), Gaps = 8/160 (5%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
+ED E ++ E + +E+ +++++ +R+ EE+ Q QE+ +REQE +
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEK 682
Query: 270 LQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQE 329
+Q E++ R QEE+ Q E+K E + +E++ GQ + M+ + + +
Sbjct: 683 MQGQEEKM-REQEEKMRGQ---EEKMWGQEEKMWGQEEKMWGQEE----MREKEERIRDQ 734
Query: 330 KDRLWQRLQHLSSMAPECCVACSKIFGRFSRRYPCRLCGG 369
K+++ +RL E C+ SK+ S GG
Sbjct: 735 KEKMQERLPEHEERCSEPCLPPSKVLCNMSHTGSVEPAGG 774
Score = 47.4 bits (111), Expect = 2e-05
Identities = 33/114 (28%), Positives = 65/114 (57%), Gaps = 13/114 (11%)
Query: 230 REEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL---QALREQLSRCQEERAE 286
RE++ ++ Q+E +R+ E++ + QE+ LREQE EL + LREQ + QE+ +
Sbjct: 265 REQEGKMREQEE------KMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEK 318
Query: 287 LQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHL 340
+ Q E+K +E E + +E L Q + M+ + ++ +++R+W++ + L
Sbjct: 319 MWEQ-EEKMREQEEKMWRQEERLWEQE---KQMREQEQKMRDQEERMWEQDERL 368
Score = 46.6 bits (109), Expect = 4e-05
Identities = 32/107 (29%), Positives = 62/107 (57%), Gaps = 8/107 (7%)
Query: 230 REEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQA 289
RE++ E+ Q++ + LR+ EEQ Q QE+ + EQE +++ E++ R +E E +
Sbjct: 286 REQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 345
Query: 290 QLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQR 336
Q+ ++QE + RD QEE ++D R E ++E++++W++
Sbjct: 346 QM--REQEQKMRD---QEERMWEQD---ERLREKEERMREQEKMWEQ 384
Score = 43.5 bits (101), Expect = 3e-04
Identities = 30/132 (22%), Positives = 66/132 (50%), Gaps = 12/132 (9%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLR 264
Q +E+ + + +T REE+ + +++ +R+ EE+ Q QE+ +R
Sbjct: 532 QEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMR 591
Query: 265 EQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVL 324
EQE + + EQ + QE+ ++ Q E+K E E D M ++E + M +
Sbjct: 592 EQE---EKMWEQEEKMQEQEEKMWEQ-EEKMWEQEEEDKMQEQE--------EMMWEQEE 639
Query: 325 ELIQEKDRLWQR 336
++ ++++++W++
Sbjct: 640 KMQEQEEKMWEQ 651
Score = 43.1 bits (100), Expect = 4e-04
Identities = 35/113 (30%), Positives = 61/113 (53%), Gaps = 9/113 (7%)
Query: 232 EQAEVSLQDEIKSLRLGLR--KAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQA 289
EQ E + E K R R + E+Q + QEQ +R+QE + E+L R +EER Q
Sbjct: 321 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL-REKEERMREQE 379
Query: 290 QL---EQKQQEAER---RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQR 336
++ E+K QE ER R+ +EE R+ + M+++ + +++++ WQ+
Sbjct: 380 KMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ 432
Score = 41.6 bits (96), Expect = 0.001
Identities = 28/118 (23%), Positives = 62/118 (52%), Gaps = 10/118 (8%)
Query: 229 RREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQ 288
R EQ ++ Q+E +R+ E++ + +E+ +REQE ++Q E + +E+ + Q
Sbjct: 374 RMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 433
Query: 289 AQLEQKQ--------QEAERRDAMYQEELGGQRDLVQAMKR--RVLELIQEKDRLWQR 336
EQK+ QE E + +E++ Q ++ K+ R ++ +++D++W++
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 491
Score = 41.2 bits (95), Expect = 0.002
Identities = 26/108 (24%), Positives = 59/108 (54%), Gaps = 8/108 (7%)
Query: 229 RREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQ 288
R EQ ++ Q+E ++ E++ QE+ +RE+E +RE+ + +EE E+
Sbjct: 522 RMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEE----RMREREKKMREEE-EMM 576
Query: 289 AQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQR 336
+ E+K QE E + +E++ Q + +Q + ++ E +++++W++
Sbjct: 577 REQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE---QEEKMWEQ 621
Score = 39.3 bits (90), Expect = 0.006
Identities = 57/270 (21%), Positives = 105/270 (38%), Gaps = 34/270 (12%)
Query: 68 QQRHLPFFLEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGK 127
QQ+ LP EK E + + +WE E K DQEE W GQ K
Sbjct: 431 QQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR--DQEEM--W-------------GQEK 473
Query: 128 GAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGT--HKKEAEWSHVQRLLMPSPRGAVEGAV 185
+K M + + E R E ++E W +RL R + +
Sbjct: 474 KMWRQEK----MREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKM 529
Query: 186 ----SGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDE 241
R+ + W + +E+ E + E + R +E+ +++
Sbjct: 530 WQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEK 589
Query: 242 IKSLRLGLRKAEEQAQRQEQLLREQEGEL------QALREQLSRCQEERAELQAQLEQKQ 295
++ + + EE+ Q QE+ + EQE ++ ++EQ E+ ++Q Q E+K
Sbjct: 590 MREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQ-EEKM 648
Query: 296 QEAERRDAMYQEELGGQRDLVQAMKRRVLE 325
E E + +E++ Q + +Q + ++ E
Sbjct: 649 WEQEEKMREQEEKMREQEEKMQGQEEKMRE 678
Score = 38.5 bits (88), Expect = 0.011
Identities = 27/112 (24%), Positives = 62/112 (55%), Gaps = 13/112 (11%)
Query: 230 REEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEG--ELQALREQLSRCQEERAEL 287
R+++ + QDE LR+ EE+ + QE++ ++E E + +RE+ + +EE +
Sbjct: 355 RDQEERMWEQDE------RLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM 408
Query: 288 QAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE---LIQEKDRLWQR 336
+ Q E+ Q++ E + QEE Q+ + K ++ E + ++++++W++
Sbjct: 409 REQEEKMQKQEE--NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ 458
Score = 38.1 bits (87), Expect = 0.014
Identities = 26/137 (18%), Positives = 71/137 (51%), Gaps = 7/137 (5%)
Query: 209 TKEDSTVENPQVQTEVTLVARREEQAEVS-----LQDEIKSLRLGLRKAEEQAQRQEQLL 263
TKE + + +T +++ AE+ + E ++L +++ + + +R + LL
Sbjct: 165 TKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLL 224
Query: 264 REQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRV 323
+ + L+E++ R +EE E + ++ +++++ R++ +E+ G R+ + M+R+
Sbjct: 225 PQVQ--TNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQE 282
Query: 324 LELIQEKDRLWQRLQHL 340
L +++ L ++ + L
Sbjct: 283 KRLREQEKELREQEKEL 299
Score = 36.2 bits (82), Expect = 0.053
Identities = 32/139 (23%), Positives = 69/139 (49%), Gaps = 9/139 (6%)
Query: 202 WVLQGHATKEDSTVENPQVQTEVTLVARREE----QAEVSLQDEIKSLRLGLRKAEEQAQ 257
W Q +++ E ++Q + + +EE Q E+ Q++ + +R+ E+Q
Sbjct: 430 WQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW 489
Query: 258 RQEQLLREQEGEL----QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQR 313
QE+ +R+QE ++ + + EQ R +E+ ++ Q + QQE + R+ +E ++
Sbjct: 490 EQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQE-QEKK 548
Query: 314 DLVQAMKRRVLELIQEKDR 332
Q K R E ++E+++
Sbjct: 549 TWDQEEKMREEERMREREK 567
Score = 34.7 bits (78), Expect = 0.16
Identities = 29/140 (20%), Positives = 69/140 (49%), Gaps = 9/140 (6%)
Query: 200 EPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQ 259
E W + +++ E E R +EQ ++ + LR+ EE+ + Q
Sbjct: 467 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQ 526
Query: 260 EQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER---RDAMYQEELGGQRDLV 316
+++ +++E +RE+ + QE+ + Q E+K +E ER R+ +EE R+
Sbjct: 527 KKMWQQEE----KMREE-KKTQEQEKKTWDQ-EEKMREEERMREREKKMREEEEMMREQE 580
Query: 317 QAMKRRVLELIQEKDRLWQR 336
+ M+ + ++ ++++++W++
Sbjct: 581 EKMQEQEEKMREQEEKMWEQ 600
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 51.6 bits (122), Expect = 1e-06
Identities = 38/129 (29%), Positives = 73/129 (56%), Gaps = 11/129 (8%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKS---LRLGLRKAEEQAQRQEQLLREQEG----ELQ 271
Q+Q E + + E E LQ ++++ L L ++ +++ Q QE++LREQE E +
Sbjct: 299 QLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQE 358
Query: 272 ALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
L EQ R +E++ LQ Q E+ +++ E+R +E L + + +Q ++R L +++
Sbjct: 359 RLCEQNERLREQQKTLQEQGERLRKQ-EQRLRKQEERLRKEEERLQKQEKR---LWDQEE 414
Query: 332 RLWQRLQHL 340
RLW++ + L
Sbjct: 415 RLWKKEERL 423
Score = 38.5 bits (88), Expect = 0.011
Identities = 28/117 (23%), Positives = 54/117 (46%)
Query: 224 VTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEE 283
VT V + + L+ E++ L L+ E Q L +EQ+ LQ E L + +
Sbjct: 293 VTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQ 352
Query: 284 RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHL 340
R Q +L ++ + + QE+ R Q ++++ L +E++RL ++ + L
Sbjct: 353 RVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRL 409
Score = 36.6 bits (83), Expect = 0.041
Identities = 31/109 (28%), Positives = 57/109 (52%), Gaps = 9/109 (8%)
Query: 230 REEQAEVSLQDE-IKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQL------SRCQE 282
RE+Q + Q E ++ LRK EE+ +++E+ L++QE L E+L + QE
Sbjct: 368 REQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQE 427
Query: 283 ERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
ER L + +Q AE + + E+L ++ ++++V EL ++ D
Sbjct: 428 ERLALSQNHKLDKQLAEPQCSF--EDLNNEKKSALQLEQQVKELQEKLD 474
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 51.6 bits (122), Expect = 1e-06
Identities = 38/129 (29%), Positives = 73/129 (56%), Gaps = 11/129 (8%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKS---LRLGLRKAEEQAQRQEQLLREQEG----ELQ 271
Q+Q E + + E E LQ ++++ L L ++ +++ Q QE++LREQE E +
Sbjct: 299 QLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQE 358
Query: 272 ALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
L EQ R +E++ LQ Q E+ +++ E+R +E L + + +Q ++R L +++
Sbjct: 359 RLCEQNERLREQQKTLQEQGERLRKQ-EQRLRKQEERLRKEEERLQKQEKR---LWDQEE 414
Query: 332 RLWQRLQHL 340
RLW++ + L
Sbjct: 415 RLWKKEERL 423
Score = 38.5 bits (88), Expect = 0.011
Identities = 28/117 (23%), Positives = 54/117 (46%)
Query: 224 VTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEE 283
VT V + + L+ E++ L L+ E Q L +EQ+ LQ E L + +
Sbjct: 293 VTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQ 352
Query: 284 RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHL 340
R Q +L ++ + + QE+ R Q ++++ L +E++RL ++ + L
Sbjct: 353 RVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRL 409
Score = 36.6 bits (83), Expect = 0.041
Identities = 31/109 (28%), Positives = 57/109 (52%), Gaps = 9/109 (8%)
Query: 230 REEQAEVSLQDE-IKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQL------SRCQE 282
RE+Q + Q E ++ LRK EE+ +++E+ L++QE L E+L + QE
Sbjct: 368 REQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQE 427
Query: 283 ERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
ER L + +Q AE + + E+L ++ ++++V EL ++ D
Sbjct: 428 ERLALSQNHKLDKQLAEPQCSF--EDLNNEKKSALQLEQQVKELQEKLD 474
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 51.6 bits (122), Expect = 1e-06
Identities = 35/104 (33%), Positives = 60/104 (57%), Gaps = 2/104 (1%)
Query: 221 QTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQ-ALREQLSR 279
+ E+ + + +E+ E LQ E++ L+ R+AE Q +E+ R Q ELQ AL QL
Sbjct: 344 EEELLRLQQLQEEKERKLQ-ELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLRE 402
Query: 280 CQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRV 323
++ RA +QA++E K++EA R+ +E Q+ L +A++ V
Sbjct: 403 AEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEV 446
Score = 45.8 bits (107), Expect = 7e-05
Identities = 40/137 (29%), Positives = 69/137 (50%), Gaps = 22/137 (16%)
Query: 224 VTLVARREEQAEVSLQDEIKSLRLGLRKAEEQ--AQRQEQLLR------EQEGELQALR- 274
+ + R + + + SL ++K R R+ E+ A ++E+LLR E+E +LQ L
Sbjct: 307 IQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQEEKERKLQELEL 366
Query: 275 --------EQLSRCQEERA-----ELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKR 321
E+L + +EER ELQ LE + +EAE+ A Q E+ + + ++
Sbjct: 367 LQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEEAARQRQ 426
Query: 322 RVLELIQEKDRLWQRLQ 338
R+ EL + + RL + LQ
Sbjct: 427 RIKELEEMQQRLQEALQ 443
Score = 41.2 bits (95), Expect = 0.002
Identities = 45/185 (24%), Positives = 78/185 (42%), Gaps = 12/185 (6%)
Query: 140 EAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQ-RLLMPSPRGAVEGAVSGSRQGSGGSSIL 198
E ++ + L+ E QR E ++E E Q R L + G + A +
Sbjct: 358 ERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELK 417
Query: 199 GEPWVLQGHATKE-DSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQ 257
E Q KE + + Q ++ + ARR+E++ Q + L + EE+ +
Sbjct: 418 EEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRL------LEEEEEKLK 471
Query: 258 RQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAE----RRDAMYQEELGGQR 313
+ QL EQE ++ +++ Q+E A+ L+Q QQ+ E R ++ QR
Sbjct: 472 QLMQLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQR 531
Query: 314 DLVQA 318
L QA
Sbjct: 532 KLRQA 536
Score = 29.3 bits (64), Expect = 6.5
Identities = 26/101 (25%), Positives = 52/101 (51%), Gaps = 12/101 (11%)
Query: 239 QDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEA 298
Q+ ++++ +R E + L+++ E + RE+ +EE +L+Q Q+E
Sbjct: 301 QEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRERRRAAKEEEL---LRLQQLQEEK 357
Query: 299 ERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQH 339
ER+ +EL +L+Q +R+ L+QE++ +R QH
Sbjct: 358 ERK----LQEL----ELLQEAQRQAERLLQEEEER-RRSQH 389
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 51.6 bits (122), Expect = 1e-06
Identities = 36/145 (24%), Positives = 67/145 (46%), Gaps = 5/145 (3%)
Query: 237 SLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAE---LQAQLEQ 293
SLQ +I L + E + +++ + + +LQ ++ LS + E + L+ +
Sbjct: 465 SLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKKEFLN 524
Query: 294 KQQEAERRDAMYQEELGGQRDLVQAMKRRVLEL--IQEKDRLWQRLQHLSSMAPECCVAC 351
Q E ++ +Y E+ ++L + L++ I+E ++ Q L L C C
Sbjct: 525 LQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANKALQGLVWLKDKEATHCKLC 584
Query: 352 SKIFGRFSRRYPCRLCGGLLCHACS 376
K F R++ CR CG + C+ACS
Sbjct: 585 EKEFSLSKRKHHCRNCGEIFCNACS 609
Score = 30.8 bits (68), Expect = 2.2
Identities = 29/129 (22%), Positives = 58/129 (44%), Gaps = 11/129 (8%)
Query: 211 EDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAE-------EQAQRQEQLL 263
E+ ++ E+ L + E+ QD + LR L + + ++ Q E L
Sbjct: 351 ENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEEVKAINIEMYQKLQGSEDGL 410
Query: 264 REQEGELQALREQLSRCQEERAELQAQLEQ---KQQEAERRDAMYQEELGGQRDLVQ-AM 319
+E+ + L E+ ++ +L+ +L+Q Q EAE D Y +E + D +Q +
Sbjct: 411 KEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYLQECLSKSDSLQKQI 470
Query: 320 KRRVLELIQ 328
++ +L+Q
Sbjct: 471 SQKEKQLVQ 479
>gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo
sapiens]
Length = 693
Score = 51.6 bits (122), Expect = 1e-06
Identities = 38/129 (29%), Positives = 73/129 (56%), Gaps = 11/129 (8%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKS---LRLGLRKAEEQAQRQEQLLREQEG----ELQ 271
Q+Q E + + E E LQ ++++ L L ++ +++ Q QE++LREQE E +
Sbjct: 299 QLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQE 358
Query: 272 ALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
L EQ R +E++ LQ Q E+ +++ E+R +E L + + +Q ++R L +++
Sbjct: 359 RLCEQNERLREQQKTLQEQGERLRKQ-EQRLRKQEERLRKEEERLQKQEKR---LWDQEE 414
Query: 332 RLWQRLQHL 340
RLW++ + L
Sbjct: 415 RLWKKEERL 423
Score = 38.5 bits (88), Expect = 0.011
Identities = 28/117 (23%), Positives = 54/117 (46%)
Query: 224 VTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEE 283
VT V + + L+ E++ L L+ E Q L +EQ+ LQ E L + +
Sbjct: 293 VTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQ 352
Query: 284 RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHL 340
R Q +L ++ + + QE+ R Q ++++ L +E++RL ++ + L
Sbjct: 353 RVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRL 409
Score = 36.6 bits (83), Expect = 0.041
Identities = 31/109 (28%), Positives = 57/109 (52%), Gaps = 9/109 (8%)
Query: 230 REEQAEVSLQDE-IKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQL------SRCQE 282
RE+Q + Q E ++ LRK EE+ +++E+ L++QE L E+L + QE
Sbjct: 368 REQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQE 427
Query: 283 ERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
ER L + +Q AE + + E+L ++ ++++V EL ++ D
Sbjct: 428 ERLALSQNHKLDKQLAEPQCSF--EDLNNEKKSALQLEQQVKELQEKLD 474
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 50.8 bits (120), Expect = 2e-06
Identities = 38/129 (29%), Positives = 73/129 (56%), Gaps = 11/129 (8%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKS---LRLGLRKAEEQAQRQEQLLREQE----GELQ 271
Q+Q E + + E E LQ ++++ L L ++ +++ Q QE++LREQE E +
Sbjct: 299 QLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQRVREQE 358
Query: 272 ALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
L EQ R +E++ LQ Q E+ +++ E+R +E L + + +Q ++R L +++
Sbjct: 359 RLCEQNERLREQQKTLQEQGERLRKQ-EQRLRKQEERLRKEEERLQKQEKR---LWDQEE 414
Query: 332 RLWQRLQHL 340
RLW++ + L
Sbjct: 415 RLWKKEERL 423
Score = 38.1 bits (87), Expect = 0.014
Identities = 28/117 (23%), Positives = 54/117 (46%)
Query: 224 VTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEE 283
VT V + + L+ E++ L L+ E Q L +EQ+ LQ E L + +
Sbjct: 293 VTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQ 352
Query: 284 RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHL 340
R Q +L ++ + + QE+ R Q ++++ L +E++RL ++ + L
Sbjct: 353 RVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRL 409
Score = 36.2 bits (82), Expect = 0.053
Identities = 38/135 (28%), Positives = 65/135 (48%), Gaps = 16/135 (11%)
Query: 227 VARREEQAEVSLQDE-IKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSR------ 279
V R EQ + Q+E ++ + L++ E+ ++QEQ LR+QE L+ E+L +
Sbjct: 351 VQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEERLQKQEKRLW 410
Query: 280 CQEERAELQAQLEQKQQEA------ERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
QEER + + QKQ+E + D E DL K+ L+L Q+ L
Sbjct: 411 DQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDL-NNEKKSALQLEQQVKEL 469
Query: 334 WQRL--QHLSSMAPE 346
++L +HL + + +
Sbjct: 470 QEKLDEEHLEAASQQ 484
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 50.4 bits (119), Expect = 3e-06
Identities = 32/112 (28%), Positives = 63/112 (56%), Gaps = 3/112 (2%)
Query: 228 ARREEQAEVSLQDEIKSLRLG-LRKAEEQAQRQEQLLREQEGELQALRE--QLSRCQEER 284
A++ E+ E + E ++ RL L++ EE+ + QE L +++E E + LR+ + R E+R
Sbjct: 629 AKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQR 688
Query: 285 AELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQR 336
+ + + E+++QE ++ QE +R L + +RR E +Q + L +R
Sbjct: 689 EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 740
Score = 43.5 bits (101), Expect = 3e-04
Identities = 31/110 (28%), Positives = 62/110 (56%), Gaps = 7/110 (6%)
Query: 226 LVARREEQAEVSLQDEIKSLRLGLRKAEE--QAQRQEQLLREQEGELQALRE---QLSRC 280
L+ +++E+ + L+ ++ RL ++ +E + +R+EQ REQE Q RE QL+
Sbjct: 663 LLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQ 722
Query: 281 QEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEK 330
+ R + + Q E++ QE E+ + +E+L QR+L + K+ + + E+
Sbjct: 723 ERRREQERLQAERELQEREKALRLQKEQL--QRELEEKKKKEEQQRLAER 770
Score = 42.4 bits (98), Expect = 7e-04
Identities = 38/108 (35%), Positives = 58/108 (53%), Gaps = 8/108 (7%)
Query: 231 EEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQ 290
E + + LQ + + + LRKA E + EQ REQE Q REQ R QE R Q +
Sbjct: 657 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQ--REQERREQERREQERREQERRE--QER 712
Query: 291 LEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
EQ++Q AE+ QE L +R+L + + + L L +K++L + L+
Sbjct: 713 REQERQLAEQERRREQERLQAERELQE--REKALRL--QKEQLQRELE 756
Score = 35.4 bits (80), Expect = 0.091
Identities = 29/124 (23%), Positives = 58/124 (46%), Gaps = 9/124 (7%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEIKSL-------RLGLRKAEEQAQRQEQLLREQEG 268
E + E+ + EEQ + E K L R + E++ + QE+ +E+
Sbjct: 655 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE 714
Query: 269 ELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEEL--GGQRDLVQAMKRRVLEL 326
+ + L EQ R ++ER + + +L+++++ + Q EL +++ Q + R L+
Sbjct: 715 QERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 774
Query: 327 IQEK 330
QEK
Sbjct: 775 EQEK 778
Score = 34.7 bits (78), Expect = 0.16
Identities = 22/94 (23%), Positives = 50/94 (53%), Gaps = 2/94 (2%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
+E E + + E RRE++ +++ Q+ + +AE + Q +E+ LR Q+ +
Sbjct: 693 REQERREQERREQERREQERREQERQLAEQERRREQER--LQAERELQEREKALRLQKEQ 750
Query: 270 LQALREQLSRCQEERAELQAQLEQKQQEAERRDA 303
LQ E+ + +E++ + QL+++Q++ + A
Sbjct: 751 LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
Score = 34.3 bits (77), Expect = 0.20
Identities = 37/133 (27%), Positives = 63/133 (47%), Gaps = 9/133 (6%)
Query: 203 VLQGHATKEDSTVENP-QVQTEVTLVARREEQA-EVSLQDEIKSLRLGLRKAEEQAQRQE 260
VLQ E E Q++ + + + E+A E L +E + +K EE R
Sbjct: 581 VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR-- 638
Query: 261 QLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER-RDAMYQEELGGQRDLVQAM 319
R+QE E + LR L + +EER + ++K++E ER R A + L QR+ +
Sbjct: 639 ---RKQEEEARRLR-WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 694
Query: 320 KRRVLELIQEKDR 332
+ R + +E++R
Sbjct: 695 QERREQERREQER 707
Score = 33.9 bits (76), Expect = 0.27
Identities = 20/82 (24%), Positives = 40/82 (48%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLR 264
Q +E E + + ++ RR EQ + + E++ LR +EQ QR+ + +
Sbjct: 700 QERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKK 759
Query: 265 EQEGELQALREQLSRCQEERAE 286
++E + + QL QE++A+
Sbjct: 760 KKEEQQRLAERQLQEEQEKKAK 781
Score = 31.6 bits (70), Expect = 1.3
Identities = 23/99 (23%), Positives = 55/99 (55%), Gaps = 2/99 (2%)
Query: 230 REEQAEVSLQDEIKSLRLGLRKAEEQAQRQ-EQLLREQEGELQALREQLSRCQEERAELQ 288
+E Q +L+ + ++ +L +K EE +R+ E++ ++E L+ + + R ++ + E +
Sbjct: 537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK 596
Query: 289 AQLEQK-QQEAERRDAMYQEELGGQRDLVQAMKRRVLEL 326
Q+EQK Q E+ + +E L ++ +A +++ E+
Sbjct: 597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 635
Score = 30.0 bits (66), Expect = 3.8
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 23/128 (17%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALRE 275
E Q++ + +R EV L+ E + LR L+ E Q +E+ ++ E + + E
Sbjct: 550 EAEQLRRQKVEEDKRRRLEEVKLKRE-ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDE 608
Query: 276 QLSRCQEER-AELQA------------QLEQKQQEAERRDAMYQEELGGQRDLVQAMKRR 322
+ + +EER AE +A + +KQ+E RR Q+E +RR
Sbjct: 609 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE---------EEERR 659
Query: 323 VLELIQEK 330
EL+Q+K
Sbjct: 660 HQELLQKK 667
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 50.4 bits (119), Expect = 3e-06
Identities = 32/112 (28%), Positives = 63/112 (56%), Gaps = 3/112 (2%)
Query: 228 ARREEQAEVSLQDEIKSLRLG-LRKAEEQAQRQEQLLREQEGELQALRE--QLSRCQEER 284
A++ E+ E + E ++ RL L++ EE+ + QE L +++E E + LR+ + R E+R
Sbjct: 625 AKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQR 684
Query: 285 AELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQR 336
+ + + E+++QE ++ QE +R L + +RR E +Q + L +R
Sbjct: 685 EQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 736
Score = 43.5 bits (101), Expect = 3e-04
Identities = 31/110 (28%), Positives = 62/110 (56%), Gaps = 7/110 (6%)
Query: 226 LVARREEQAEVSLQDEIKSLRLGLRKAEE--QAQRQEQLLREQEGELQALRE---QLSRC 280
L+ +++E+ + L+ ++ RL ++ +E + +R+EQ REQE Q RE QL+
Sbjct: 659 LLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQ 718
Query: 281 QEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEK 330
+ R + + Q E++ QE E+ + +E+L QR+L + K+ + + E+
Sbjct: 719 ERRREQERLQAERELQEREKALRLQKEQL--QRELEEKKKKEEQQRLAER 766
Score = 42.4 bits (98), Expect = 7e-04
Identities = 38/108 (35%), Positives = 58/108 (53%), Gaps = 8/108 (7%)
Query: 231 EEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQ 290
E + + LQ + + + LRKA E + EQ REQE Q REQ R QE R Q +
Sbjct: 653 ERRHQELLQKKKEEEQERLRKAAEAKRLAEQ--REQERREQERREQERREQERRE--QER 708
Query: 291 LEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
EQ++Q AE+ QE L +R+L + + + L L +K++L + L+
Sbjct: 709 REQERQLAEQERRREQERLQAERELQE--REKALRL--QKEQLQRELE 752
Score = 35.4 bits (80), Expect = 0.091
Identities = 29/124 (23%), Positives = 58/124 (46%), Gaps = 9/124 (7%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEIKSL-------RLGLRKAEEQAQRQEQLLREQEG 268
E + E+ + EEQ + E K L R + E++ + QE+ +E+
Sbjct: 651 EEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERRE 710
Query: 269 ELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEEL--GGQRDLVQAMKRRVLEL 326
+ + L EQ R ++ER + + +L+++++ + Q EL +++ Q + R L+
Sbjct: 711 QERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 770
Query: 327 IQEK 330
QEK
Sbjct: 771 EQEK 774
Score = 34.7 bits (78), Expect = 0.16
Identities = 22/94 (23%), Positives = 50/94 (53%), Gaps = 2/94 (2%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
+E E + + E RRE++ +++ Q+ + +AE + Q +E+ LR Q+ +
Sbjct: 689 REQERREQERREQERREQERREQERQLAEQERRREQER--LQAERELQEREKALRLQKEQ 746
Query: 270 LQALREQLSRCQEERAELQAQLEQKQQEAERRDA 303
LQ E+ + +E++ + QL+++Q++ + A
Sbjct: 747 LQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 780
Score = 34.3 bits (77), Expect = 0.20
Identities = 37/133 (27%), Positives = 63/133 (47%), Gaps = 9/133 (6%)
Query: 203 VLQGHATKEDSTVENP-QVQTEVTLVARREEQA-EVSLQDEIKSLRLGLRKAEEQAQRQE 260
VLQ E E Q++ + + + E+A E L +E + +K EE R
Sbjct: 577 VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEAR-- 634
Query: 261 QLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER-RDAMYQEELGGQRDLVQAM 319
R+QE E + LR L + +EER + ++K++E ER R A + L QR+ +
Sbjct: 635 ---RKQEEEARRLR-WLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 690
Query: 320 KRRVLELIQEKDR 332
+ R + +E++R
Sbjct: 691 QERREQERREQER 703
Score = 33.9 bits (76), Expect = 0.27
Identities = 20/82 (24%), Positives = 40/82 (48%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLR 264
Q +E E + + ++ RR EQ + + E++ LR +EQ QR+ + +
Sbjct: 696 QERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKK 755
Query: 265 EQEGELQALREQLSRCQEERAE 286
++E + + QL QE++A+
Sbjct: 756 KKEEQQRLAERQLQEEQEKKAK 777
Score = 31.6 bits (70), Expect = 1.3
Identities = 23/99 (23%), Positives = 55/99 (55%), Gaps = 2/99 (2%)
Query: 230 REEQAEVSLQDEIKSLRLGLRKAEEQAQRQ-EQLLREQEGELQALREQLSRCQEERAELQ 288
+E Q +L+ + ++ +L +K EE +R+ E++ ++E L+ + + R ++ + E +
Sbjct: 533 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKK 592
Query: 289 AQLEQK-QQEAERRDAMYQEELGGQRDLVQAMKRRVLEL 326
Q+EQK Q E+ + +E L ++ +A +++ E+
Sbjct: 593 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 631
Score = 30.0 bits (66), Expect = 3.8
Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 23/128 (17%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALRE 275
E Q++ + +R EV L+ E + LR L+ E Q +E+ ++ E + + E
Sbjct: 546 EAEQLRRQKVEEDKRRRLEEVKLKRE-ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDE 604
Query: 276 QLSRCQEER-AELQA------------QLEQKQQEAERRDAMYQEELGGQRDLVQAMKRR 322
+ + +EER AE +A + +KQ+E RR Q+E +RR
Sbjct: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE---------EEERR 655
Query: 323 VLELIQEK 330
EL+Q+K
Sbjct: 656 HQELLQKK 663
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 50.1 bits (118), Expect = 4e-06
Identities = 40/138 (28%), Positives = 71/138 (51%), Gaps = 11/138 (7%)
Query: 215 VENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALR 274
VEN Q+ ++L+ RR+E+ ++ ++ LR+ EE+ QE+ LREQE + LR
Sbjct: 184 VENNQM---LSLLNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQE---ERLR 237
Query: 275 EQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE----LIQEK 330
EQ R E+ L+ + E++ E E R +E L Q + + + R+ E L +++
Sbjct: 238 EQEERLCEQEERLR-EHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQE 296
Query: 331 DRLWQRLQHLSSMAPECC 348
+RL ++ + L C
Sbjct: 297 ERLCEQEERLREQEERLC 314
Score = 41.6 bits (96), Expect = 0.001
Identities = 33/122 (27%), Positives = 61/122 (50%), Gaps = 10/122 (8%)
Query: 229 RREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQ 288
R E+ ++ + LR+ EE+ QE+ L EQE L+ E+L +E E +
Sbjct: 251 REHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQE 310
Query: 289 AQL-EQKQQEAERRDAM-YQEELGGQRDLV--------QAMKRRVLELIQEKDRLWQRLQ 338
+L EQ+++ E+ + + QE+L GQ L+ Q ++ E + E++RL + ++
Sbjct: 311 ERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVE 370
Query: 339 HL 340
L
Sbjct: 371 EL 372
Score = 37.4 bits (85), Expect = 0.024
Identities = 36/126 (28%), Positives = 57/126 (45%), Gaps = 16/126 (12%)
Query: 238 LQDEIKSLRLGLRKAEEQAQRQEQ-------LLREQEGELQALREQLSRCQEERAELQ-- 288
LQDE LR L Q Q + + L R QE L+ E+L R QEER Q
Sbjct: 162 LQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERL-REQEERLREQEE 220
Query: 289 --AQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE----LIQEKDRLWQRLQHLSS 342
+ E++ +E E R +E L Q + ++ + R+ E L ++++RL ++ + L
Sbjct: 221 RLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHE 280
Query: 343 MAPECC 348
C
Sbjct: 281 QEERLC 286
Score = 36.2 bits (82), Expect = 0.053
Identities = 33/119 (27%), Positives = 57/119 (47%), Gaps = 15/119 (12%)
Query: 229 RREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLRE-------QEGEL----QALREQL 277
R +E+ ++ ++ LR+ EE+ QE+ LRE QE L + LREQ
Sbjct: 216 REQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQE 275
Query: 278 SRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQR 336
R E+ L Q E++ +E E R +E L Q + + + R+ E +++RL ++
Sbjct: 276 ERLHEQEERLCEQ-EERLREQEERLCEQEERLREQEERLCEQEERLRE---QEERLCEQ 330
Score = 34.3 bits (77), Expect = 0.20
Identities = 34/120 (28%), Positives = 58/120 (48%), Gaps = 29/120 (24%)
Query: 230 REEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEG----------------ELQAL 273
RE++ + Q+E LR+ EE+ QE+ LREQE E++ L
Sbjct: 293 REQEERLCEQEE------RLREQEERLCEQEERLREQEERLCEQEKLPGQERLLEEVEKL 346
Query: 274 REQLSRCQEERAELQAQ--LEQKQQEAERRDAMYQEELGGQRDLVQAMKR-----RVLEL 326
EQ R +E+ L+ + LE+ ++ E+ Q+E Q++ +Q ++R R+LEL
Sbjct: 347 LEQERRQEEQERLLERERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLEL 406
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 49.3 bits (116), Expect = 6e-06
Identities = 39/134 (29%), Positives = 71/134 (52%), Gaps = 7/134 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLRE-----QEGEL 270
E + + E +ARR+++ + Q E + + L ++ EE+ Q+QE+ LR +E E
Sbjct: 768 EEERKRREEEELARRKQEEALRRQRE-QEIALRRQREEEERQQQEEALRRLEERRREEEE 826
Query: 271 QALREQLSRCQEERAELQAQLEQK-QQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQE 329
+ +E+L R QEE A A+ E++ Q+ E +EE R + KR+ LE+ ++
Sbjct: 827 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 886
Query: 330 KDRLWQRLQHLSSM 343
K+ + QR Q ++
Sbjct: 887 KELMRQRQQQQEAL 900
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/135 (27%), Positives = 68/135 (50%), Gaps = 14/135 (10%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL-------- 270
Q + E+ L +REE+ ++ ++ L R+ EE+ ++QE+LLR+QE E
Sbjct: 791 QREQEIALRRQREEEERQQQEEALRRLE-ERRREEEERRKQEELLRKQEEEAAKWAREEE 849
Query: 271 ---QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELI 327
+ L E R +EE A L+ E+++++ + + Q+EL QR Q RR+ +
Sbjct: 850 EAQRRLEENRLRMEEEAARLRH--EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQ 907
Query: 328 QEKDRLWQRLQHLSS 342
Q++ +L S+
Sbjct: 908 QQQQLAQMKLPSSST 922
Score = 43.5 bits (101), Expect = 3e-04
Identities = 32/131 (24%), Positives = 66/131 (50%), Gaps = 12/131 (9%)
Query: 200 EPWVLQGHATKE---DSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQA 256
+P V +G + + D+T P ++ + + E+ L+ E + + ++ EE+
Sbjct: 694 QPTVWEGGSVWDLPLDTTTPGPALEQ----LQQLEKAKAAKLEQERREAEMRAKREEEER 749
Query: 257 QRQEQLLREQEGELQALREQLSRCQEE-----RAELQAQLEQKQQEAERRDAMYQEELGG 311
+RQE+L R+QE L+ +E+ + +EE R + +A Q++QE R +EE
Sbjct: 750 KRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQ 809
Query: 312 QRDLVQAMKRR 322
Q + ++ ++ R
Sbjct: 810 QEEALRRLEER 820
Score = 42.4 bits (98), Expect = 7e-04
Identities = 39/127 (30%), Positives = 68/127 (53%), Gaps = 10/127 (7%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLR---LGLRKAEEQAQRQEQLL--REQEGELQAL 273
Q + E + A+REE+ E Q+E++ + L ++ EE+ +R+E+ L R+QE L+
Sbjct: 733 QERREAEMRAKREEE-ERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 791
Query: 274 REQ--LSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
REQ R Q E E Q Q E ++ ERR +EE Q +L++ + + +E++
Sbjct: 792 REQEIALRRQREEEERQQQEEALRRLEERR--REEEERRKQEELLRKQEEEAAKWAREEE 849
Query: 332 RLWQRLQ 338
+RL+
Sbjct: 850 EAQRRLE 856
Score = 38.9 bits (89), Expect = 0.008
Identities = 30/101 (29%), Positives = 55/101 (54%), Gaps = 2/101 (1%)
Query: 240 DEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAE 299
++++ L EQ +R+ ++ ++E E + +E+L R QEE Q + E+K++E E
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 777
Query: 300 RRDAMYQEE-LGGQRDLVQAMKR-RVLELIQEKDRLWQRLQ 338
QEE L QR+ A++R R E Q+++ +RL+
Sbjct: 778 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 818
Score = 35.8 bits (81), Expect = 0.070
Identities = 28/122 (22%), Positives = 65/122 (53%), Gaps = 30/122 (24%)
Query: 229 RREEQAEVSLQDEIKSLRLG---LRKAEEQAQRQEQLLREQEGELQALR--------EQL 277
RR E+ + +++E LR ++ E + QRQ++L+R+++ + +ALR +QL
Sbjct: 853 RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 912
Query: 278 SR-----------------CQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMK 320
++ CQ + A++++ ++E ER+ + +E+ QR+L++A++
Sbjct: 913 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ--LREEQRRQQRELMKALQ 970
Query: 321 RR 322
++
Sbjct: 971 QQ 972
Score = 34.7 bits (78), Expect = 0.16
Identities = 24/94 (25%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
+ ++T Q + + + EE+ E L++E + + L KA +Q Q+Q+Q G
Sbjct: 926 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGN 985
Query: 270 LQ----ALREQLSRCQEERAELQAQLEQKQQEAE 299
+ + L QEE ++Q Q +Q+QQ +
Sbjct: 986 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQ 1019
Score = 33.9 bits (76), Expect = 0.27
Identities = 24/113 (21%), Positives = 55/113 (48%), Gaps = 4/113 (3%)
Query: 221 QTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC 280
+ E AR EE+A+ L++ RL + + + + +E+ + +E E+Q +E + +
Sbjct: 838 EEEAAKWAREEEEAQRRLEEN----RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 893
Query: 281 QEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
Q+++ L+ +Q+QQ+ + + GQ+ A + + + E +L
Sbjct: 894 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL 946
Score = 29.3 bits (64), Expect = 6.5
Identities = 32/144 (22%), Positives = 65/144 (45%), Gaps = 20/144 (13%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEV-------SLQDEIKSLRL------GLRKAEEQA 256
+E+ + +VQ + L+ +R++Q E Q ++ ++L G +
Sbjct: 873 EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 932
Query: 257 QRQEQLLREQEGELQALREQLSRCQEERA--ELQAQLEQKQQEAERRDAMYQEELGGQRD 314
Q Q L + +L+ RE+ R ++ R EL L+Q+QQ+ +++ + + G
Sbjct: 933 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGW-----GNVS 987
Query: 315 LVQAMKRRVLELIQEKDRLWQRLQ 338
+ +LE+ QE+ R Q+ Q
Sbjct: 988 KPSGTTKSLLEIQQEEARQMQKQQ 1011
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 49.3 bits (116), Expect = 6e-06
Identities = 39/134 (29%), Positives = 71/134 (52%), Gaps = 7/134 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLRE-----QEGEL 270
E + + E +ARR+++ + Q E + + L ++ EE+ Q+QE+ LR +E E
Sbjct: 795 EEERKRREEEELARRKQEEALRRQRE-QEIALRRQREEEERQQQEEALRRLEERRREEEE 853
Query: 271 QALREQLSRCQEERAELQAQLEQK-QQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQE 329
+ +E+L R QEE A A+ E++ Q+ E +EE R + KR+ LE+ ++
Sbjct: 854 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 913
Query: 330 KDRLWQRLQHLSSM 343
K+ + QR Q ++
Sbjct: 914 KELMRQRQQQQEAL 927
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/135 (27%), Positives = 68/135 (50%), Gaps = 14/135 (10%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL-------- 270
Q + E+ L +REE+ ++ ++ L R+ EE+ ++QE+LLR+QE E
Sbjct: 818 QREQEIALRRQREEEERQQQEEALRRLE-ERRREEEERRKQEELLRKQEEEAAKWAREEE 876
Query: 271 ---QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELI 327
+ L E R +EE A L+ E+++++ + + Q+EL QR Q RR+ +
Sbjct: 877 EAQRRLEENRLRMEEEAARLRH--EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQ 934
Query: 328 QEKDRLWQRLQHLSS 342
Q++ +L S+
Sbjct: 935 QQQQLAQMKLPSSST 949
Score = 43.5 bits (101), Expect = 3e-04
Identities = 32/131 (24%), Positives = 66/131 (50%), Gaps = 12/131 (9%)
Query: 200 EPWVLQGHATKE---DSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQA 256
+P V +G + + D+T P ++ + + E+ L+ E + + ++ EE+
Sbjct: 721 QPTVWEGGSVWDLPLDTTTPGPALEQ----LQQLEKAKAAKLEQERREAEMRAKREEEER 776
Query: 257 QRQEQLLREQEGELQALREQLSRCQEE-----RAELQAQLEQKQQEAERRDAMYQEELGG 311
+RQE+L R+QE L+ +E+ + +EE R + +A Q++QE R +EE
Sbjct: 777 KRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQ 836
Query: 312 QRDLVQAMKRR 322
Q + ++ ++ R
Sbjct: 837 QEEALRRLEER 847
Score = 42.4 bits (98), Expect = 7e-04
Identities = 39/127 (30%), Positives = 68/127 (53%), Gaps = 10/127 (7%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLR---LGLRKAEEQAQRQEQLL--REQEGELQAL 273
Q + E + A+REE+ E Q+E++ + L ++ EE+ +R+E+ L R+QE L+
Sbjct: 760 QERREAEMRAKREEE-ERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 818
Query: 274 REQ--LSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
REQ R Q E E Q Q E ++ ERR +EE Q +L++ + + +E++
Sbjct: 819 REQEIALRRQREEEERQQQEEALRRLEERR--REEEERRKQEELLRKQEEEAAKWAREEE 876
Query: 332 RLWQRLQ 338
+RL+
Sbjct: 877 EAQRRLE 883
Score = 38.9 bits (89), Expect = 0.008
Identities = 30/101 (29%), Positives = 55/101 (54%), Gaps = 2/101 (1%)
Query: 240 DEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAE 299
++++ L EQ +R+ ++ ++E E + +E+L R QEE Q + E+K++E E
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 804
Query: 300 RRDAMYQEE-LGGQRDLVQAMKR-RVLELIQEKDRLWQRLQ 338
QEE L QR+ A++R R E Q+++ +RL+
Sbjct: 805 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 845
Score = 35.8 bits (81), Expect = 0.070
Identities = 28/122 (22%), Positives = 65/122 (53%), Gaps = 30/122 (24%)
Query: 229 RREEQAEVSLQDEIKSLRLG---LRKAEEQAQRQEQLLREQEGELQALR--------EQL 277
RR E+ + +++E LR ++ E + QRQ++L+R+++ + +ALR +QL
Sbjct: 880 RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 939
Query: 278 SR-----------------CQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMK 320
++ CQ + A++++ ++E ER+ + +E+ QR+L++A++
Sbjct: 940 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ--LREEQRRQQRELMKALQ 997
Query: 321 RR 322
++
Sbjct: 998 QQ 999
Score = 34.7 bits (78), Expect = 0.16
Identities = 24/94 (25%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
+ ++T Q + + + EE+ E L++E + + L KA +Q Q+Q+Q G
Sbjct: 953 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGN 1012
Query: 270 LQ----ALREQLSRCQEERAELQAQLEQKQQEAE 299
+ + L QEE ++Q Q +Q+QQ +
Sbjct: 1013 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQ 1046
Score = 33.9 bits (76), Expect = 0.27
Identities = 24/113 (21%), Positives = 55/113 (48%), Gaps = 4/113 (3%)
Query: 221 QTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC 280
+ E AR EE+A+ L++ RL + + + + +E+ + +E E+Q +E + +
Sbjct: 865 EEEAAKWAREEEEAQRRLEEN----RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 920
Query: 281 QEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
Q+++ L+ +Q+QQ+ + + GQ+ A + + + E +L
Sbjct: 921 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL 973
Score = 29.3 bits (64), Expect = 6.5
Identities = 32/144 (22%), Positives = 65/144 (45%), Gaps = 20/144 (13%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEV-------SLQDEIKSLRL------GLRKAEEQA 256
+E+ + +VQ + L+ +R++Q E Q ++ ++L G +
Sbjct: 900 EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 959
Query: 257 QRQEQLLREQEGELQALREQLSRCQEERA--ELQAQLEQKQQEAERRDAMYQEELGGQRD 314
Q Q L + +L+ RE+ R ++ R EL L+Q+QQ+ +++ + + G
Sbjct: 960 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGW-----GNVS 1014
Query: 315 LVQAMKRRVLELIQEKDRLWQRLQ 338
+ +LE+ QE+ R Q+ Q
Sbjct: 1015 KPSGTTKSLLEIQQEEARQMQKQQ 1038
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 49.3 bits (116), Expect = 6e-06
Identities = 39/134 (29%), Positives = 71/134 (52%), Gaps = 7/134 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLRE-----QEGEL 270
E + + E +ARR+++ + Q E + + L ++ EE+ Q+QE+ LR +E E
Sbjct: 774 EEERKRREEEELARRKQEEALRRQRE-QEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Query: 271 QALREQLSRCQEERAELQAQLEQK-QQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQE 329
+ +E+L R QEE A A+ E++ Q+ E +EE R + KR+ LE+ ++
Sbjct: 833 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 892
Query: 330 KDRLWQRLQHLSSM 343
K+ + QR Q ++
Sbjct: 893 KELMRQRQQQQEAL 906
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/135 (27%), Positives = 68/135 (50%), Gaps = 14/135 (10%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL-------- 270
Q + E+ L +REE+ ++ ++ L R+ EE+ ++QE+LLR+QE E
Sbjct: 797 QREQEIALRRQREEEERQQQEEALRRLE-ERRREEEERRKQEELLRKQEEEAAKWAREEE 855
Query: 271 ---QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELI 327
+ L E R +EE A L+ E+++++ + + Q+EL QR Q RR+ +
Sbjct: 856 EAQRRLEENRLRMEEEAARLRH--EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQ 913
Query: 328 QEKDRLWQRLQHLSS 342
Q++ +L S+
Sbjct: 914 QQQQLAQMKLPSSST 928
Score = 43.5 bits (101), Expect = 3e-04
Identities = 32/131 (24%), Positives = 66/131 (50%), Gaps = 12/131 (9%)
Query: 200 EPWVLQGHATKE---DSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQA 256
+P V +G + + D+T P ++ + + E+ L+ E + + ++ EE+
Sbjct: 700 QPTVWEGGSVWDLPLDTTTPGPALEQ----LQQLEKAKAAKLEQERREAEMRAKREEEER 755
Query: 257 QRQEQLLREQEGELQALREQLSRCQEE-----RAELQAQLEQKQQEAERRDAMYQEELGG 311
+RQE+L R+QE L+ +E+ + +EE R + +A Q++QE R +EE
Sbjct: 756 KRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQ 815
Query: 312 QRDLVQAMKRR 322
Q + ++ ++ R
Sbjct: 816 QEEALRRLEER 826
Score = 42.4 bits (98), Expect = 7e-04
Identities = 39/127 (30%), Positives = 68/127 (53%), Gaps = 10/127 (7%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLR---LGLRKAEEQAQRQEQLL--REQEGELQAL 273
Q + E + A+REE+ E Q+E++ + L ++ EE+ +R+E+ L R+QE L+
Sbjct: 739 QERREAEMRAKREEE-ERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 274 REQ--LSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
REQ R Q E E Q Q E ++ ERR +EE Q +L++ + + +E++
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERR--REEEERRKQEELLRKQEEEAAKWAREEE 855
Query: 332 RLWQRLQ 338
+RL+
Sbjct: 856 EAQRRLE 862
Score = 38.9 bits (89), Expect = 0.008
Identities = 30/101 (29%), Positives = 55/101 (54%), Gaps = 2/101 (1%)
Query: 240 DEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAE 299
++++ L EQ +R+ ++ ++E E + +E+L R QEE Q + E+K++E E
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 783
Query: 300 RRDAMYQEE-LGGQRDLVQAMKR-RVLELIQEKDRLWQRLQ 338
QEE L QR+ A++R R E Q+++ +RL+
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 824
Score = 35.8 bits (81), Expect = 0.070
Identities = 28/122 (22%), Positives = 65/122 (53%), Gaps = 30/122 (24%)
Query: 229 RREEQAEVSLQDEIKSLRLG---LRKAEEQAQRQEQLLREQEGELQALR--------EQL 277
RR E+ + +++E LR ++ E + QRQ++L+R+++ + +ALR +QL
Sbjct: 859 RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 918
Query: 278 SR-----------------CQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMK 320
++ CQ + A++++ ++E ER+ + +E+ QR+L++A++
Sbjct: 919 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ--LREEQRRQQRELMKALQ 976
Query: 321 RR 322
++
Sbjct: 977 QQ 978
Score = 34.7 bits (78), Expect = 0.16
Identities = 24/94 (25%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
+ ++T Q + + + EE+ E L++E + + L KA +Q Q+Q+Q G
Sbjct: 932 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGN 991
Query: 270 LQ----ALREQLSRCQEERAELQAQLEQKQQEAE 299
+ + L QEE ++Q Q +Q+QQ +
Sbjct: 992 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQ 1025
Score = 33.9 bits (76), Expect = 0.27
Identities = 24/113 (21%), Positives = 55/113 (48%), Gaps = 4/113 (3%)
Query: 221 QTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC 280
+ E AR EE+A+ L++ RL + + + + +E+ + +E E+Q +E + +
Sbjct: 844 EEEAAKWAREEEEAQRRLEEN----RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 899
Query: 281 QEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
Q+++ L+ +Q+QQ+ + + GQ+ A + + + E +L
Sbjct: 900 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL 952
Score = 29.3 bits (64), Expect = 6.5
Identities = 32/144 (22%), Positives = 65/144 (45%), Gaps = 20/144 (13%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEV-------SLQDEIKSLRL------GLRKAEEQA 256
+E+ + +VQ + L+ +R++Q E Q ++ ++L G +
Sbjct: 879 EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 938
Query: 257 QRQEQLLREQEGELQALREQLSRCQEERA--ELQAQLEQKQQEAERRDAMYQEELGGQRD 314
Q Q L + +L+ RE+ R ++ R EL L+Q+QQ+ +++ + + G
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGW-----GNVS 993
Query: 315 LVQAMKRRVLELIQEKDRLWQRLQ 338
+ +LE+ QE+ R Q+ Q
Sbjct: 994 KPSGTTKSLLEIQQEEARQMQKQQ 1017
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 49.3 bits (116), Expect = 6e-06
Identities = 39/134 (29%), Positives = 71/134 (52%), Gaps = 7/134 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLRE-----QEGEL 270
E + + E +ARR+++ + Q E + + L ++ EE+ Q+QE+ LR +E E
Sbjct: 774 EEERKRREEEELARRKQEEALRRQRE-QEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Query: 271 QALREQLSRCQEERAELQAQLEQK-QQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQE 329
+ +E+L R QEE A A+ E++ Q+ E +EE R + KR+ LE+ ++
Sbjct: 833 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQ 892
Query: 330 KDRLWQRLQHLSSM 343
K+ + QR Q ++
Sbjct: 893 KELMRQRQQQQEAL 906
Score = 47.4 bits (111), Expect = 2e-05
Identities = 37/135 (27%), Positives = 68/135 (50%), Gaps = 14/135 (10%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL-------- 270
Q + E+ L +REE+ ++ ++ L R+ EE+ ++QE+LLR+QE E
Sbjct: 797 QREQEIALRRQREEEERQQQEEALRRLE-ERRREEEERRKQEELLRKQEEEAAKWAREEE 855
Query: 271 ---QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELI 327
+ L E R +EE A L+ E+++++ + + Q+EL QR Q RR+ +
Sbjct: 856 EAQRRLEENRLRMEEEAARLRH--EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQ 913
Query: 328 QEKDRLWQRLQHLSS 342
Q++ +L S+
Sbjct: 914 QQQQLAQMKLPSSST 928
Score = 43.5 bits (101), Expect = 3e-04
Identities = 32/131 (24%), Positives = 66/131 (50%), Gaps = 12/131 (9%)
Query: 200 EPWVLQGHATKE---DSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQA 256
+P V +G + + D+T P ++ + + E+ L+ E + + ++ EE+
Sbjct: 700 QPTVWEGGSVWDLPLDTTTPGPALEQ----LQQLEKAKAAKLEQERREAEMRAKREEEER 755
Query: 257 QRQEQLLREQEGELQALREQLSRCQEE-----RAELQAQLEQKQQEAERRDAMYQEELGG 311
+RQE+L R+QE L+ +E+ + +EE R + +A Q++QE R +EE
Sbjct: 756 KRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQ 815
Query: 312 QRDLVQAMKRR 322
Q + ++ ++ R
Sbjct: 816 QEEALRRLEER 826
Score = 42.4 bits (98), Expect = 7e-04
Identities = 39/127 (30%), Positives = 68/127 (53%), Gaps = 10/127 (7%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLR---LGLRKAEEQAQRQEQLL--REQEGELQAL 273
Q + E + A+REE+ E Q+E++ + L ++ EE+ +R+E+ L R+QE L+
Sbjct: 739 QERREAEMRAKREEE-ERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ 797
Query: 274 REQ--LSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKD 331
REQ R Q E E Q Q E ++ ERR +EE Q +L++ + + +E++
Sbjct: 798 REQEIALRRQREEEERQQQEEALRRLEERR--REEEERRKQEELLRKQEEEAAKWAREEE 855
Query: 332 RLWQRLQ 338
+RL+
Sbjct: 856 EAQRRLE 862
Score = 38.9 bits (89), Expect = 0.008
Identities = 30/101 (29%), Positives = 55/101 (54%), Gaps = 2/101 (1%)
Query: 240 DEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAE 299
++++ L EQ +R+ ++ ++E E + +E+L R QEE Q + E+K++E E
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEE 783
Query: 300 RRDAMYQEE-LGGQRDLVQAMKR-RVLELIQEKDRLWQRLQ 338
QEE L QR+ A++R R E Q+++ +RL+
Sbjct: 784 ELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 824
Score = 35.8 bits (81), Expect = 0.070
Identities = 28/122 (22%), Positives = 65/122 (53%), Gaps = 30/122 (24%)
Query: 229 RREEQAEVSLQDEIKSLRLG---LRKAEEQAQRQEQLLREQEGELQALR--------EQL 277
RR E+ + +++E LR ++ E + QRQ++L+R+++ + +ALR +QL
Sbjct: 859 RRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQL 918
Query: 278 SR-----------------CQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMK 320
++ CQ + A++++ ++E ER+ + +E+ QR+L++A++
Sbjct: 919 AQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQ--LREEQRRQQRELMKALQ 976
Query: 321 RR 322
++
Sbjct: 977 QQ 978
Score = 34.7 bits (78), Expect = 0.16
Identities = 24/94 (25%), Positives = 45/94 (47%), Gaps = 4/94 (4%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGE 269
+ ++T Q + + + EE+ E L++E + + L KA +Q Q+Q+Q G
Sbjct: 932 QSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGN 991
Query: 270 LQ----ALREQLSRCQEERAELQAQLEQKQQEAE 299
+ + L QEE ++Q Q +Q+QQ +
Sbjct: 992 VSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQ 1025
Score = 33.9 bits (76), Expect = 0.27
Identities = 24/113 (21%), Positives = 55/113 (48%), Gaps = 4/113 (3%)
Query: 221 QTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC 280
+ E AR EE+A+ L++ RL + + + + +E+ + +E E+Q +E + +
Sbjct: 844 EEEAAKWAREEEEAQRRLEEN----RLRMEEEAARLRHEEEERKRKELEVQRQKELMRQR 899
Query: 281 QEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
Q+++ L+ +Q+QQ+ + + GQ+ A + + + E +L
Sbjct: 900 QQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKL 952
Score = 29.3 bits (64), Expect = 6.5
Identities = 32/144 (22%), Positives = 65/144 (45%), Gaps = 20/144 (13%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEV-------SLQDEIKSLRL------GLRKAEEQA 256
+E+ + +VQ + L+ +R++Q E Q ++ ++L G +
Sbjct: 879 EEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTAC 938
Query: 257 QRQEQLLREQEGELQALREQLSRCQEERA--ELQAQLEQKQQEAERRDAMYQEELGGQRD 314
Q Q L + +L+ RE+ R ++ R EL L+Q+QQ+ +++ + + G
Sbjct: 939 QSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGW-----GNVS 993
Query: 315 LVQAMKRRVLELIQEKDRLWQRLQ 338
+ +LE+ QE+ R Q+ Q
Sbjct: 994 KPSGTTKSLLEIQQEEARQMQKQQ 1017
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 49.3 bits (116), Expect = 6e-06
Identities = 34/119 (28%), Positives = 62/119 (52%), Gaps = 2/119 (1%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQD-EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALR 274
E +++ E T AR+ Q E L ++ L KA +A+ + +LR+++ + L+
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 275 EQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
E+ + ++ AE A+L QEA R + +E+L QR L + M + ++ +QE RL
Sbjct: 2268 EEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Score = 47.8 bits (112), Expect = 2e-05
Identities = 90/393 (22%), Positives = 145/393 (36%), Gaps = 100/393 (25%)
Query: 24 APKKIPAAYGGPENVQIE-----------DSHTSQAI-----CLQDAPSGQQLAGLPRSQ 67
+P K P G E+V E + TSQ I L+ ++LA R++
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357
Query: 68 QQRHLPFF---LEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQG 124
++ L LEK+ + + H ++ E E KELQ +E E+
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREEAAVDAQ 1412
Query: 125 QGKGAMGTQKEVI--GMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVE 182
Q K ++ + + + EAE+ AE + ++E +Q RG E
Sbjct: 1413 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1472
Query: 183 GAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEI 242
G + R + + A K + E +++ +V ++R+ QAEV L +
Sbjct: 1473 GELQALRARAE-----------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 243 KS-----------------LRLG-------LRKAEEQAQRQEQLL-----REQEGELQAL 273
K+ LRL LR+AE + RQ Q+ R E ELQ+
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1581
Query: 274 RE---------------------QLSRCQEERAELQAQLEQKQQEAERRDAMYQ------ 306
R QL E RA+ QA+ E+ ++EAER +Q
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEA 1641
Query: 307 -------EELGGQRDLVQAMKRRVLELIQEKDR 332
EE+ Q+ L QA + E + + R
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/136 (22%), Positives = 72/136 (52%), Gaps = 8/136 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEI----KSLRLGLRKAEEQAQRQEQLLREQEGELQ 271
E ++Q E L+ + E+ + Q+++ ++L+ ++ ++E+ + +++ +L+
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 272 AL-REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEK 330
L ++++++ Q+ R E Q Q +Q +QE +R A +E Q + + ++R+ EL Q +
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Query: 331 DRLWQRLQHLSSMAPE 346
QR Q +A E
Sbjct: 2578 Q---QRRQQEELLAEE 2590
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 215 VENPQVQTEVTLVARREEQA-EVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQAL 273
+++ ++QT +E QA + S E SL R E++ + EQL +++ + Q L
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530
Query: 274 REQLSRCQE----ERAELQAQLEQ---KQQEAERRDAMYQEELGGQRDLVQAMKRRVLEL 326
RE+ R Q+ ER L A +E+ +Q EAE QEEL + L Q +++ L
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL---QQLEQQRRQQEELL 2587
Query: 327 IQEKDRLWQRLQHL 340
+E RL ++LQ L
Sbjct: 2588 AEENQRLREQLQLL 2601
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/128 (26%), Positives = 62/128 (48%), Gaps = 19/128 (14%)
Query: 220 VQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSR 279
+Q E VA+ E+AE Q + ++ R A E+A+R+ + + + E LR Q
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAER-----AREEAERELERWQLKANEALRLRLQAEE 1650
Query: 280 CQEERAELQAQLEQKQQEAE--------------RRDAMYQEELGGQRDLVQAMKRRVLE 325
++++ QA+ E++++EAE R+ + ++EL QR L + ++ L
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 326 LIQEKDRL 333
QE RL
Sbjct: 1711 AEQELIRL 1718
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/239 (25%), Positives = 100/239 (41%), Gaps = 41/239 (17%)
Query: 127 KGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVS 186
K A T ++ +E E+T + L E E H+K +QRL A
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLE-----ETDHQKNLLDEELQRLKAE--------ATE 2218
Query: 187 GSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLR 246
+RQ S L V +K + +E L+ R ++ + LQ+E + ++
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIE----AENRALILRDKDNTQRFLQEEAEKMK 2274
Query: 247 ------LGLRKAEEQAQRQEQLLREQEGELQALREQL-----------SRCQEERAELQA 289
L A ++A R QL E + +AL E++ +R + E LQ
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 290 QLEQKQQEAER----RDAMYQ---EELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
Q E Q++A R ++ M Q EE G + ++A ++R LE+ E +RL R+ +S
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393
Score = 40.4 bits (93), Expect = 0.003
Identities = 45/184 (24%), Positives = 84/184 (45%), Gaps = 28/184 (15%)
Query: 199 GEPWVLQGHAT--KEDSTVENPQVQTEVTLVARREEQAEVSLQDE-IKSLRLGLRKAEEQ 255
G VL+ H KE V + E T + ++ +A+ Q +LR LR A+E
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1159
Query: 256 AQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER--RDAMYQEE----L 309
+R +Q E++ E++ RE++++ E + AQ + +Q+E E+ R Y E L
Sbjct: 1160 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1219
Query: 310 GG-------QRDLVQAM----KRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRF 358
G +++ +QAM + V E ++++ L + ++ EC RF
Sbjct: 1220 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC--------QRF 1271
Query: 359 SRRY 362
+++Y
Sbjct: 1272 AKQY 1275
Score = 38.9 bits (89), Expect = 0.008
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 27/139 (19%)
Query: 225 TLVARREEQAEVSLQDEIKSLRLG-LRKAEEQAQRQEQLLREQEGE-------------- 269
TL A R+ Q E+S + E LR+ + +A+ +A+ Q R+Q E
Sbjct: 2367 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Query: 270 -------LQALREQ----LSRCQEERAELQAQLEQKQQEAERRDAMYQE-ELGGQRDLVQ 317
L+ R+Q R +E AEL+ + E+ QQEA+ +E + Q L+Q
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2486
Query: 318 AMKRRVLELIQEKDRLWQR 336
+ + EKD L QR
Sbjct: 2487 ETQALQQSFLSEKDSLLQR 2505
Score = 38.5 bits (88), Expect = 0.011
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEE---QAQRQEQLLREQEGELQALRE 275
Q + E+ ++E+ L+ E ++ R +AEE QA+R+ R Q E + L++
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 276 QLSRCQEERAELQAQLEQKQQEAERRDA 303
+ RA+ QA E+ ++EAE+ A
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Score = 37.4 bits (85), Expect = 0.024
Identities = 64/307 (20%), Positives = 121/307 (39%), Gaps = 55/307 (17%)
Query: 77 EKKGESSRKHR------YPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAM 130
EK+ E+ R R + + E + + + D EER + + +G + +
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917
Query: 131 GTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQ 190
+++V E E+ + L A ++ G + E E ++ + R + + +RQ
Sbjct: 1918 RQRRQV---EEEI--LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 191 GSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARRE--EQAEVSLQDEIKSLRLG 248
+ A +E+ + + + +L A E Q + +L+ E++ L+
Sbjct: 1973 --------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA- 2016
Query: 249 LRKAEEQAQRQEQLLREQEGELQALREQLSR------------CQEERAELQAQLEQKQQ 296
K EE + +E+ +E +LQ +E + Q++ ELQ L+Q+Q
Sbjct: 2017 --KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 297 ---------EAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPEC 347
EA RR A EE Q + A RR +E E +RL Q + + +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQA 2131
Query: 348 CVACSKI 354
A K+
Sbjct: 2132 QAAAEKL 2138
Score = 36.6 bits (83), Expect = 0.041
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLR-KAEEQAQRQ----EQLLREQEGELQAL 273
++Q E + QAE Q E R KAEEQA RQ EQ L +Q +
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 274 REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGG-QRDLVQAMKRR 322
+Q ++E L+A+ EQ +Q+ + + +EEL QR+ A ++R
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQ----LLEEELARLQREAAAATQKR 1750
Score = 35.8 bits (81), Expect = 0.070
Identities = 30/129 (23%), Positives = 61/129 (47%), Gaps = 19/129 (14%)
Query: 227 VARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC-QEERA 285
+A QA+ + E K L+ ++ +E+ R+E+ + + + ++++E+L + Q A
Sbjct: 1375 LAEAHAQAKAQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431
Query: 286 ELQAQLEQKQQEAERRDAMYQEEL--------------GGQRDLVQAMKRRVLELIQEKD 331
E+QA+ Q + AER +EE+ GG +QA++ R E +K
Sbjct: 1432 EIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490
Query: 332 RLWQRLQHL 340
+ + + L
Sbjct: 1491 QAQEEAERL 1499
Score = 33.5 bits (75), Expect = 0.35
Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 24/153 (15%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQA----EVSLQDEIKSLRLGLRKAEEQAQRQE 260
Q + ++ + + + E + EEQA E++ Q+ K +L A+++ ++
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 261 QLLR------EQEGELQALREQLSRCQEE-------RAELQAQLEQKQQEAE-------R 300
+L+R + E + Q L E+L+R Q E R EL+A+L + + E E R
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 301 RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
+ + + ++A R EL +E RL
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1806
Score = 33.5 bits (75), Expect = 0.35
Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 2/107 (1%)
Query: 232 EQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQL 291
EQ L++E+ L+ A ++ Q E L + E++ L +R +EE +
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 292 EQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
+Q+ + R EE R L + KR+ + E+D QR +
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQ--RQLAEEDAARQRAE 1830
Score = 32.3 bits (72), Expect = 0.77
Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 19/123 (15%)
Query: 228 ARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQA-----LREQLSRCQE 282
+++ +AE E+ LR E+A+RQ QL E +A L E+L+ E
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844
Query: 283 E---RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE--LIQEKDRLWQRL 337
+ E + L++K+ E ER + ++E A +RR LE Q K + +RL
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDE---------AFQRRRLEEQAAQHKADIEERL 1895
Query: 338 QHL 340
L
Sbjct: 1896 AQL 1898
Score = 32.0 bits (71), Expect = 1.0
Identities = 40/166 (24%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQ-------EQL 262
KE + Q + V R E +A +E + R+ + Q++RQ +Q
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120
Query: 263 LREQ---EGELQALREQLSRCQEERAELQAQLEQ---KQQEA-----ERRDAMYQEELGG 311
EQ + QA E+L + E+ A +AQ EQ +Q++A E+ ++ L
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 312 QRDLVQAMKRRVLELIQ---EKDRLWQRLQHLSSMAPECCVACSKI 354
+ + Q + L+L + +K+ L + LQ L + A E S++
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226
Score = 31.6 bits (70), Expect = 1.3
Identities = 35/151 (23%), Positives = 72/151 (47%), Gaps = 18/151 (11%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSL---QDEIKSLRLGLRKAEEQA----Q 257
QG ++ E ++Q E ++ ++ E L + E++ L +AEE++ +
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 258 RQEQLLREQEGELQALREQLSRCQE--ERAELQAQLEQK-----QQEAERRDAMYQEELG 310
+ +Q L + G + L E+ +R + E A+ Q QL ++ + EAER + E+L
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLA 1840
Query: 311 GQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
+ + +K ++EK+ +RL+ L+
Sbjct: 1841 AIGEATR-LKTEAEIALKEKEAENERLRRLA 1870
Score = 31.2 bits (69), Expect = 1.7
Identities = 26/99 (26%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Query: 211 EDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL 270
+D + Q++ E ++ EQ L ++ R +AEE +R+++ L++ E
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE--- 2577
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEEL 309
Q R+Q EE L+ QL Q +E R + EE+
Sbjct: 2578 QQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEV 2615
Score = 30.0 bits (66), Expect = 3.8
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 263 LREQEGELQALREQLSRCQE-ERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKR 321
+RE EG+LQ L+E L R +R+ +LE Q+A+ +E+L + + + +
Sbjct: 731 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE----KEQLNEYKGHLSGLAK 786
Query: 322 RVLELIQEKDR 332
R ++Q K R
Sbjct: 787 RAKAVVQLKPR 797
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 49.3 bits (116), Expect = 6e-06
Identities = 34/119 (28%), Positives = 62/119 (52%), Gaps = 2/119 (1%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQD-EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALR 274
E +++ E T AR+ Q E L ++ L KA +A+ + +LR+++ + L+
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2271
Query: 275 EQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
E+ + ++ AE A+L QEA R + +E+L QR L + M + ++ +QE RL
Sbjct: 2272 EEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Score = 47.8 bits (112), Expect = 2e-05
Identities = 90/393 (22%), Positives = 145/393 (36%), Gaps = 100/393 (25%)
Query: 24 APKKIPAAYGGPENVQIE-----------DSHTSQAI-----CLQDAPSGQQLAGLPRSQ 67
+P K P G E+V E + TSQ I L+ ++LA R++
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1361
Query: 68 QQRHLPFF---LEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQG 124
++ L LEK+ + + H ++ E E KELQ +E E+
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREEAAVDAQ 1416
Query: 125 QGKGAMGTQKEVI--GMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVE 182
Q K ++ + + + EAE+ AE + ++E +Q RG E
Sbjct: 1417 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1476
Query: 183 GAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEI 242
G + R + + A K + E +++ +V ++R+ QAEV L +
Sbjct: 1477 GELQALRARAE-----------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1525
Query: 243 KS-----------------LRLG-------LRKAEEQAQRQEQLL-----REQEGELQAL 273
K+ LRL LR+AE + RQ Q+ R E ELQ+
Sbjct: 1526 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1585
Query: 274 RE---------------------QLSRCQEERAELQAQLEQKQQEAERRDAMYQ------ 306
R QL E RA+ QA+ E+ ++EAER +Q
Sbjct: 1586 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEA 1645
Query: 307 -------EELGGQRDLVQAMKRRVLELIQEKDR 332
EE+ Q+ L QA + E + + R
Sbjct: 1646 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1678
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/136 (22%), Positives = 72/136 (52%), Gaps = 8/136 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEI----KSLRLGLRKAEEQAQRQEQLLREQEGELQ 271
E ++Q E L+ + E+ + Q+++ ++L+ ++ ++E+ + +++ +L+
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2521
Query: 272 AL-REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEK 330
L ++++++ Q+ R E Q Q +Q +QE +R A +E Q + + ++R+ EL Q +
Sbjct: 2522 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2581
Query: 331 DRLWQRLQHLSSMAPE 346
QR Q +A E
Sbjct: 2582 Q---QRRQQEELLAEE 2594
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 215 VENPQVQTEVTLVARREEQA-EVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQAL 273
+++ ++QT +E QA + S E SL R E++ + EQL +++ + Q L
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2534
Query: 274 REQLSRCQE----ERAELQAQLEQ---KQQEAERRDAMYQEELGGQRDLVQAMKRRVLEL 326
RE+ R Q+ ER L A +E+ +Q EAE QEEL + L Q +++ L
Sbjct: 2535 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL---QQLEQQRRQQEELL 2591
Query: 327 IQEKDRLWQRLQHL 340
+E RL ++LQ L
Sbjct: 2592 AEENQRLREQLQLL 2605
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/128 (26%), Positives = 62/128 (48%), Gaps = 19/128 (14%)
Query: 220 VQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSR 279
+Q E VA+ E+AE Q + ++ R A E+A+R+ + + + E LR Q
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAER-----AREEAERELERWQLKANEALRLRLQAEE 1654
Query: 280 CQEERAELQAQLEQKQQEAE--------------RRDAMYQEELGGQRDLVQAMKRRVLE 325
++++ QA+ E++++EAE R+ + ++EL QR L + ++ L
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1714
Query: 326 LIQEKDRL 333
QE RL
Sbjct: 1715 AEQELIRL 1722
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/239 (25%), Positives = 100/239 (41%), Gaps = 41/239 (17%)
Query: 127 KGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVS 186
K A T ++ +E E+T + L E E H+K +QRL A
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLE-----ETDHQKNLLDEELQRLKAE--------ATE 2222
Query: 187 GSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLR 246
+RQ S L V +K + +E L+ R ++ + LQ+E + ++
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIE----AENRALILRDKDNTQRFLQEEAEKMK 2278
Query: 247 ------LGLRKAEEQAQRQEQLLREQEGELQALREQL-----------SRCQEERAELQA 289
L A ++A R QL E + +AL E++ +R + E LQ
Sbjct: 2279 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2338
Query: 290 QLEQKQQEAER----RDAMYQ---EELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
Q E Q++A R ++ M Q EE G + ++A ++R LE+ E +RL R+ +S
Sbjct: 2339 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2397
Score = 40.4 bits (93), Expect = 0.003
Identities = 45/184 (24%), Positives = 84/184 (45%), Gaps = 28/184 (15%)
Query: 199 GEPWVLQGHAT--KEDSTVENPQVQTEVTLVARREEQAEVSLQDE-IKSLRLGLRKAEEQ 255
G VL+ H KE V + E T + ++ +A+ Q +LR LR A+E
Sbjct: 1104 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1163
Query: 256 AQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER--RDAMYQEE----L 309
+R +Q E++ E++ RE++++ E + AQ + +Q+E E+ R Y E L
Sbjct: 1164 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1223
Query: 310 GG-------QRDLVQAM----KRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRF 358
G +++ +QAM + V E ++++ L + ++ EC RF
Sbjct: 1224 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC--------QRF 1275
Query: 359 SRRY 362
+++Y
Sbjct: 1276 AKQY 1279
Score = 38.9 bits (89), Expect = 0.008
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 27/139 (19%)
Query: 225 TLVARREEQAEVSLQDEIKSLRLG-LRKAEEQAQRQEQLLREQEGE-------------- 269
TL A R+ Q E+S + E LR+ + +A+ +A+ Q R+Q E
Sbjct: 2371 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2430
Query: 270 -------LQALREQ----LSRCQEERAELQAQLEQKQQEAERRDAMYQE-ELGGQRDLVQ 317
L+ R+Q R +E AEL+ + E+ QQEA+ +E + Q L+Q
Sbjct: 2431 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2490
Query: 318 AMKRRVLELIQEKDRLWQR 336
+ + EKD L QR
Sbjct: 2491 ETQALQQSFLSEKDSLLQR 2509
Score = 38.5 bits (88), Expect = 0.011
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEE---QAQRQEQLLREQEGELQALRE 275
Q + E+ ++E+ L+ E ++ R +AEE QA+R+ R Q E + L++
Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123
Query: 276 QLSRCQEERAELQAQLEQKQQEAERRDA 303
+ RA+ QA E+ ++EAE+ A
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQEAA 2151
Score = 37.4 bits (85), Expect = 0.024
Identities = 64/307 (20%), Positives = 121/307 (39%), Gaps = 55/307 (17%)
Query: 77 EKKGESSRKHR------YPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAM 130
EK+ E+ R R + + E + + + D EER + + +G + +
Sbjct: 1862 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1921
Query: 131 GTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQ 190
+++V E E+ + L A ++ G + E E ++ + R + + +RQ
Sbjct: 1922 RQRRQV---EEEI--LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 191 GSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARRE--EQAEVSLQDEIKSLRLG 248
+ A +E+ + + + +L A E Q + +L+ E++ L+
Sbjct: 1977 --------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA- 2020
Query: 249 LRKAEEQAQRQEQLLREQEGELQALREQLSR------------CQEERAELQAQLEQKQQ 296
K EE + +E+ +E +LQ +E + Q++ ELQ L+Q+Q
Sbjct: 2021 --KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Query: 297 ---------EAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPEC 347
EA RR A EE Q + A RR +E E +RL Q + + +
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQA 2135
Query: 348 CVACSKI 354
A K+
Sbjct: 2136 QAAAEKL 2142
Score = 36.6 bits (83), Expect = 0.041
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLR-KAEEQAQRQ----EQLLREQEGELQAL 273
++Q E + QAE Q E R KAEEQA RQ EQ L +Q +
Sbjct: 1649 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 274 REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGG-QRDLVQAMKRR 322
+Q ++E L+A+ EQ +Q+ + + +EEL QR+ A ++R
Sbjct: 1709 AQQRLAAEQELIRLRAETEQGEQQRQ----LLEEELARLQREAAAATQKR 1754
Score = 35.8 bits (81), Expect = 0.070
Identities = 30/129 (23%), Positives = 61/129 (47%), Gaps = 19/129 (14%)
Query: 227 VARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC-QEERA 285
+A QA+ + E K L+ ++ +E+ R+E+ + + + ++++E+L + Q A
Sbjct: 1379 LAEAHAQAKAQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1435
Query: 286 ELQAQLEQKQQEAERRDAMYQEEL--------------GGQRDLVQAMKRRVLELIQEKD 331
E+QA+ Q + AER +EE+ GG +QA++ R E +K
Sbjct: 1436 EIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1494
Query: 332 RLWQRLQHL 340
+ + + L
Sbjct: 1495 QAQEEAERL 1503
Score = 33.5 bits (75), Expect = 0.35
Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 24/153 (15%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQA----EVSLQDEIKSLRLGLRKAEEQAQRQE 260
Q + ++ + + + E + EEQA E++ Q+ K +L A+++ ++
Sbjct: 1658 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717
Query: 261 QLLR------EQEGELQALREQLSRCQEE-------RAELQAQLEQKQQEAE-------R 300
+L+R + E + Q L E+L+R Q E R EL+A+L + + E E R
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777
Query: 301 RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
+ + + ++A R EL +E RL
Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1810
Score = 33.5 bits (75), Expect = 0.35
Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 2/107 (1%)
Query: 232 EQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQL 291
EQ L++E+ L+ A ++ Q E L + E++ L +R +EE +
Sbjct: 1730 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 292 EQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
+Q+ + R EE R L + KR+ + E+D QR +
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQ--RQLAEEDAARQRAE 1834
Score = 32.3 bits (72), Expect = 0.77
Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 19/123 (15%)
Query: 228 ARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQA-----LREQLSRCQE 282
+++ +AE E+ LR E+A+RQ QL E +A L E+L+ E
Sbjct: 1789 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1848
Query: 283 E---RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE--LIQEKDRLWQRL 337
+ E + L++K+ E ER + ++E A +RR LE Q K + +RL
Sbjct: 1849 ATRLKTEAEIALKEKEAENERLRRLAEDE---------AFQRRRLEEQAAQHKADIEERL 1899
Query: 338 QHL 340
L
Sbjct: 1900 AQL 1902
Score = 32.0 bits (71), Expect = 1.0
Identities = 40/166 (24%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQ-------EQL 262
KE + Q + V R E +A +E + R+ + Q++RQ +Q
Sbjct: 2065 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2124
Query: 263 LREQ---EGELQALREQLSRCQEERAELQAQLEQ---KQQEA-----ERRDAMYQEELGG 311
EQ + QA E+L + E+ A +AQ EQ +Q++A E+ ++ L
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184
Query: 312 QRDLVQAMKRRVLELIQ---EKDRLWQRLQHLSSMAPECCVACSKI 354
+ + Q + L+L + +K+ L + LQ L + A E S++
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2230
Score = 31.6 bits (70), Expect = 1.3
Identities = 35/151 (23%), Positives = 72/151 (47%), Gaps = 18/151 (11%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSL---QDEIKSLRLGLRKAEEQA----Q 257
QG ++ E ++Q E ++ ++ E L + E++ L +AEE++ +
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787
Query: 258 RQEQLLREQEGELQALREQLSRCQE--ERAELQAQLEQK-----QQEAERRDAMYQEELG 310
+ +Q L + G + L E+ +R + E A+ Q QL ++ + EAER + E+L
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLA 1844
Query: 311 GQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
+ + +K ++EK+ +RL+ L+
Sbjct: 1845 AIGEATR-LKTEAEIALKEKEAENERLRRLA 1874
Score = 31.2 bits (69), Expect = 1.7
Identities = 26/99 (26%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Query: 211 EDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL 270
+D + Q++ E ++ EQ L ++ R +AEE +R+++ L++ E
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE--- 2581
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEEL 309
Q R+Q EE L+ QL Q +E R + EE+
Sbjct: 2582 QQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEV 2619
Score = 30.0 bits (66), Expect = 3.8
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 263 LREQEGELQALREQLSRCQE-ERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKR 321
+RE EG+LQ L+E L R +R+ +LE Q+A+ +E+L + + + +
Sbjct: 735 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE----KEQLNEYKGHLSGLAK 790
Query: 322 RVLELIQEKDR 332
R ++Q K R
Sbjct: 791 RAKAVVQLKPR 801
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 49.3 bits (116), Expect = 6e-06
Identities = 34/119 (28%), Positives = 62/119 (52%), Gaps = 2/119 (1%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQD-EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALR 274
E +++ E T AR+ Q E L ++ L KA +A+ + +LR+++ + L+
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2267
Query: 275 EQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
E+ + ++ AE A+L QEA R + +E+L QR L + M + ++ +QE RL
Sbjct: 2268 EEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Score = 47.8 bits (112), Expect = 2e-05
Identities = 90/393 (22%), Positives = 145/393 (36%), Gaps = 100/393 (25%)
Query: 24 APKKIPAAYGGPENVQIE-----------DSHTSQAI-----CLQDAPSGQQLAGLPRSQ 67
+P K P G E+V E + TSQ I L+ ++LA R++
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357
Query: 68 QQRHLPFF---LEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQG 124
++ L LEK+ + + H ++ E E KELQ +E E+
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREEAAVDAQ 1412
Query: 125 QGKGAMGTQKEVI--GMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVE 182
Q K ++ + + + EAE+ AE + ++E +Q RG E
Sbjct: 1413 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1472
Query: 183 GAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEI 242
G + R + + A K + E +++ +V ++R+ QAEV L +
Sbjct: 1473 GELQALRARAE-----------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 243 KS-----------------LRLG-------LRKAEEQAQRQEQLL-----REQEGELQAL 273
K+ LRL LR+AE + RQ Q+ R E ELQ+
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1581
Query: 274 RE---------------------QLSRCQEERAELQAQLEQKQQEAERRDAMYQ------ 306
R QL E RA+ QA+ E+ ++EAER +Q
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEA 1641
Query: 307 -------EELGGQRDLVQAMKRRVLELIQEKDR 332
EE+ Q+ L QA + E + + R
Sbjct: 1642 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/136 (22%), Positives = 72/136 (52%), Gaps = 8/136 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEI----KSLRLGLRKAEEQAQRQEQLLREQEGELQ 271
E ++Q E L+ + E+ + Q+++ ++L+ ++ ++E+ + +++ +L+
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2517
Query: 272 AL-REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEK 330
L ++++++ Q+ R E Q Q +Q +QE +R A +E Q + + ++R+ EL Q +
Sbjct: 2518 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577
Query: 331 DRLWQRLQHLSSMAPE 346
QR Q +A E
Sbjct: 2578 Q---QRRQQEELLAEE 2590
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 215 VENPQVQTEVTLVARREEQA-EVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQAL 273
+++ ++QT +E QA + S E SL R E++ + EQL +++ + Q L
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530
Query: 274 REQLSRCQE----ERAELQAQLEQ---KQQEAERRDAMYQEELGGQRDLVQAMKRRVLEL 326
RE+ R Q+ ER L A +E+ +Q EAE QEEL + L Q +++ L
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL---QQLEQQRRQQEELL 2587
Query: 327 IQEKDRLWQRLQHL 340
+E RL ++LQ L
Sbjct: 2588 AEENQRLREQLQLL 2601
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/128 (26%), Positives = 62/128 (48%), Gaps = 19/128 (14%)
Query: 220 VQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSR 279
+Q E VA+ E+AE Q + ++ R A E+A+R+ + + + E LR Q
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAER-----AREEAERELERWQLKANEALRLRLQAEE 1650
Query: 280 CQEERAELQAQLEQKQQEAE--------------RRDAMYQEELGGQRDLVQAMKRRVLE 325
++++ QA+ E++++EAE R+ + ++EL QR L + ++ L
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 326 LIQEKDRL 333
QE RL
Sbjct: 1711 AEQELIRL 1718
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/239 (25%), Positives = 100/239 (41%), Gaps = 41/239 (17%)
Query: 127 KGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVS 186
K A T ++ +E E+T + L E E H+K +QRL A
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLE-----ETDHQKNLLDEELQRLKAE--------ATE 2218
Query: 187 GSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLR 246
+RQ S L V +K + +E L+ R ++ + LQ+E + ++
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIE----AENRALILRDKDNTQRFLQEEAEKMK 2274
Query: 247 ------LGLRKAEEQAQRQEQLLREQEGELQALREQL-----------SRCQEERAELQA 289
L A ++A R QL E + +AL E++ +R + E LQ
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2334
Query: 290 QLEQKQQEAER----RDAMYQ---EELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
Q E Q++A R ++ M Q EE G + ++A ++R LE+ E +RL R+ +S
Sbjct: 2335 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393
Score = 40.4 bits (93), Expect = 0.003
Identities = 45/184 (24%), Positives = 84/184 (45%), Gaps = 28/184 (15%)
Query: 199 GEPWVLQGHAT--KEDSTVENPQVQTEVTLVARREEQAEVSLQDE-IKSLRLGLRKAEEQ 255
G VL+ H KE V + E T + ++ +A+ Q +LR LR A+E
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1159
Query: 256 AQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER--RDAMYQEE----L 309
+R +Q E++ E++ RE++++ E + AQ + +Q+E E+ R Y E L
Sbjct: 1160 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1219
Query: 310 GG-------QRDLVQAM----KRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRF 358
G +++ +QAM + V E ++++ L + ++ EC RF
Sbjct: 1220 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC--------QRF 1271
Query: 359 SRRY 362
+++Y
Sbjct: 1272 AKQY 1275
Score = 38.9 bits (89), Expect = 0.008
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 27/139 (19%)
Query: 225 TLVARREEQAEVSLQDEIKSLRLG-LRKAEEQAQRQEQLLREQEGE-------------- 269
TL A R+ Q E+S + E LR+ + +A+ +A+ Q R+Q E
Sbjct: 2367 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Query: 270 -------LQALREQ----LSRCQEERAELQAQLEQKQQEAERRDAMYQE-ELGGQRDLVQ 317
L+ R+Q R +E AEL+ + E+ QQEA+ +E + Q L+Q
Sbjct: 2427 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2486
Query: 318 AMKRRVLELIQEKDRLWQR 336
+ + EKD L QR
Sbjct: 2487 ETQALQQSFLSEKDSLLQR 2505
Score = 38.5 bits (88), Expect = 0.011
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEE---QAQRQEQLLREQEGELQALRE 275
Q + E+ ++E+ L+ E ++ R +AEE QA+R+ R Q E + L++
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 276 QLSRCQEERAELQAQLEQKQQEAERRDA 303
+ RA+ QA E+ ++EAE+ A
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Score = 37.4 bits (85), Expect = 0.024
Identities = 64/307 (20%), Positives = 121/307 (39%), Gaps = 55/307 (17%)
Query: 77 EKKGESSRKHR------YPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAM 130
EK+ E+ R R + + E + + + D EER + + +G + +
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917
Query: 131 GTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQ 190
+++V E E+ + L A ++ G + E E ++ + R + + +RQ
Sbjct: 1918 RQRRQV---EEEI--LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 191 GSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARRE--EQAEVSLQDEIKSLRLG 248
+ A +E+ + + + +L A E Q + +L+ E++ L+
Sbjct: 1973 --------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA- 2016
Query: 249 LRKAEEQAQRQEQLLREQEGELQALREQLSR------------CQEERAELQAQLEQKQQ 296
K EE + +E+ +E +LQ +E + Q++ ELQ L+Q+Q
Sbjct: 2017 --KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 297 ---------EAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPEC 347
EA RR A EE Q + A RR +E E +RL Q + + +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQA 2131
Query: 348 CVACSKI 354
A K+
Sbjct: 2132 QAAAEKL 2138
Score = 36.6 bits (83), Expect = 0.041
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLR-KAEEQAQRQ----EQLLREQEGELQAL 273
++Q E + QAE Q E R KAEEQA RQ EQ L +Q +
Sbjct: 1645 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 274 REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGG-QRDLVQAMKRR 322
+Q ++E L+A+ EQ +Q+ + + +EEL QR+ A ++R
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQ----LLEEELARLQREAAAATQKR 1750
Score = 35.8 bits (81), Expect = 0.070
Identities = 30/129 (23%), Positives = 61/129 (47%), Gaps = 19/129 (14%)
Query: 227 VARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC-QEERA 285
+A QA+ + E K L+ ++ +E+ R+E+ + + + ++++E+L + Q A
Sbjct: 1375 LAEAHAQAKAQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1431
Query: 286 ELQAQLEQKQQEAERRDAMYQEEL--------------GGQRDLVQAMKRRVLELIQEKD 331
E+QA+ Q + AER +EE+ GG +QA++ R E +K
Sbjct: 1432 EIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490
Query: 332 RLWQRLQHL 340
+ + + L
Sbjct: 1491 QAQEEAERL 1499
Score = 33.5 bits (75), Expect = 0.35
Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 24/153 (15%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQA----EVSLQDEIKSLRLGLRKAEEQAQRQE 260
Q + ++ + + + E + EEQA E++ Q+ K +L A+++ ++
Sbjct: 1654 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 261 QLLR------EQEGELQALREQLSRCQEE-------RAELQAQLEQKQQEAE-------R 300
+L+R + E + Q L E+L+R Q E R EL+A+L + + E E R
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 301 RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
+ + + ++A R EL +E RL
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1806
Score = 33.5 bits (75), Expect = 0.35
Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 2/107 (1%)
Query: 232 EQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQL 291
EQ L++E+ L+ A ++ Q E L + E++ L +R +EE +
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 292 EQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
+Q+ + R EE R L + KR+ + E+D QR +
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQ--RQLAEEDAARQRAE 1830
Score = 32.3 bits (72), Expect = 0.77
Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 19/123 (15%)
Query: 228 ARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQA-----LREQLSRCQE 282
+++ +AE E+ LR E+A+RQ QL E +A L E+L+ E
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844
Query: 283 E---RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE--LIQEKDRLWQRL 337
+ E + L++K+ E ER + ++E A +RR LE Q K + +RL
Sbjct: 1845 ATRLKTEAEIALKEKEAENERLRRLAEDE---------AFQRRRLEEQAAQHKADIEERL 1895
Query: 338 QHL 340
L
Sbjct: 1896 AQL 1898
Score = 32.0 bits (71), Expect = 1.0
Identities = 40/166 (24%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQ-------EQL 262
KE + Q + V R E +A +E + R+ + Q++RQ +Q
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120
Query: 263 LREQ---EGELQALREQLSRCQEERAELQAQLEQ---KQQEA-----ERRDAMYQEELGG 311
EQ + QA E+L + E+ A +AQ EQ +Q++A E+ ++ L
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 312 QRDLVQAMKRRVLELIQ---EKDRLWQRLQHLSSMAPECCVACSKI 354
+ + Q + L+L + +K+ L + LQ L + A E S++
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226
Score = 31.6 bits (70), Expect = 1.3
Identities = 35/151 (23%), Positives = 72/151 (47%), Gaps = 18/151 (11%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSL---QDEIKSLRLGLRKAEEQA----Q 257
QG ++ E ++Q E ++ ++ E L + E++ L +AEE++ +
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 258 RQEQLLREQEGELQALREQLSRCQE--ERAELQAQLEQK-----QQEAERRDAMYQEELG 310
+ +Q L + G + L E+ +R + E A+ Q QL ++ + EAER + E+L
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLA 1840
Query: 311 GQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
+ + +K ++EK+ +RL+ L+
Sbjct: 1841 AIGEATR-LKTEAEIALKEKEAENERLRRLA 1870
Score = 31.2 bits (69), Expect = 1.7
Identities = 26/99 (26%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Query: 211 EDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL 270
+D + Q++ E ++ EQ L ++ R +AEE +R+++ L++ E
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE--- 2577
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEEL 309
Q R+Q EE L+ QL Q +E R + EE+
Sbjct: 2578 QQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEV 2615
Score = 30.0 bits (66), Expect = 3.8
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 263 LREQEGELQALREQLSRCQE-ERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKR 321
+RE EG+LQ L+E L R +R+ +LE Q+A+ +E+L + + + +
Sbjct: 731 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE----KEQLNEYKGHLSGLAK 786
Query: 322 RVLELIQEKDR 332
R ++Q K R
Sbjct: 787 RAKAVVQLKPR 797
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 49.3 bits (116), Expect = 6e-06
Identities = 34/119 (28%), Positives = 62/119 (52%), Gaps = 2/119 (1%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQD-EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALR 274
E +++ E T AR+ Q E L ++ L KA +A+ + +LR+++ + L+
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2235
Query: 275 EQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
E+ + ++ AE A+L QEA R + +E+L QR L + M + ++ +QE RL
Sbjct: 2236 EEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Score = 47.8 bits (112), Expect = 2e-05
Identities = 90/393 (22%), Positives = 145/393 (36%), Gaps = 100/393 (25%)
Query: 24 APKKIPAAYGGPENVQIE-----------DSHTSQAI-----CLQDAPSGQQLAGLPRSQ 67
+P K P G E+V E + TSQ I L+ ++LA R++
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1325
Query: 68 QQRHLPFF---LEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQG 124
++ L LEK+ + + H ++ E E KELQ +E E+
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREEAAVDAQ 1380
Query: 125 QGKGAMGTQKEVI--GMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVE 182
Q K ++ + + + EAE+ AE + ++E +Q RG E
Sbjct: 1381 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1440
Query: 183 GAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEI 242
G + R + + A K + E +++ +V ++R+ QAEV L +
Sbjct: 1441 GELQALRARAE-----------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1489
Query: 243 KS-----------------LRLG-------LRKAEEQAQRQEQLL-----REQEGELQAL 273
K+ LRL LR+AE + RQ Q+ R E ELQ+
Sbjct: 1490 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1549
Query: 274 RE---------------------QLSRCQEERAELQAQLEQKQQEAERRDAMYQ------ 306
R QL E RA+ QA+ E+ ++EAER +Q
Sbjct: 1550 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEA 1609
Query: 307 -------EELGGQRDLVQAMKRRVLELIQEKDR 332
EE+ Q+ L QA + E + + R
Sbjct: 1610 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1642
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/136 (22%), Positives = 72/136 (52%), Gaps = 8/136 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEI----KSLRLGLRKAEEQAQRQEQLLREQEGELQ 271
E ++Q E L+ + E+ + Q+++ ++L+ ++ ++E+ + +++ +L+
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2485
Query: 272 AL-REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEK 330
L ++++++ Q+ R E Q Q +Q +QE +R A +E Q + + ++R+ EL Q +
Sbjct: 2486 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2545
Query: 331 DRLWQRLQHLSSMAPE 346
QR Q +A E
Sbjct: 2546 Q---QRRQQEELLAEE 2558
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 215 VENPQVQTEVTLVARREEQA-EVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQAL 273
+++ ++QT +E QA + S E SL R E++ + EQL +++ + Q L
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2498
Query: 274 REQLSRCQE----ERAELQAQLEQ---KQQEAERRDAMYQEELGGQRDLVQAMKRRVLEL 326
RE+ R Q+ ER L A +E+ +Q EAE QEEL + L Q +++ L
Sbjct: 2499 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL---QQLEQQRRQQEELL 2555
Query: 327 IQEKDRLWQRLQHL 340
+E RL ++LQ L
Sbjct: 2556 AEENQRLREQLQLL 2569
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/128 (26%), Positives = 62/128 (48%), Gaps = 19/128 (14%)
Query: 220 VQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSR 279
+Q E VA+ E+AE Q + ++ R A E+A+R+ + + + E LR Q
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAER-----AREEAERELERWQLKANEALRLRLQAEE 1618
Query: 280 CQEERAELQAQLEQKQQEAE--------------RRDAMYQEELGGQRDLVQAMKRRVLE 325
++++ QA+ E++++EAE R+ + ++EL QR L + ++ L
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1678
Query: 326 LIQEKDRL 333
QE RL
Sbjct: 1679 AEQELIRL 1686
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/239 (25%), Positives = 100/239 (41%), Gaps = 41/239 (17%)
Query: 127 KGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVS 186
K A T ++ +E E+T + L E E H+K +QRL A
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLE-----ETDHQKNLLDEELQRLKAE--------ATE 2186
Query: 187 GSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLR 246
+RQ S L V +K + +E L+ R ++ + LQ+E + ++
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIE----AENRALILRDKDNTQRFLQEEAEKMK 2242
Query: 247 ------LGLRKAEEQAQRQEQLLREQEGELQALREQL-----------SRCQEERAELQA 289
L A ++A R QL E + +AL E++ +R + E LQ
Sbjct: 2243 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2302
Query: 290 QLEQKQQEAER----RDAMYQ---EELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
Q E Q++A R ++ M Q EE G + ++A ++R LE+ E +RL R+ +S
Sbjct: 2303 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2361
Score = 40.4 bits (93), Expect = 0.003
Identities = 45/184 (24%), Positives = 84/184 (45%), Gaps = 28/184 (15%)
Query: 199 GEPWVLQGHAT--KEDSTVENPQVQTEVTLVARREEQAEVSLQDE-IKSLRLGLRKAEEQ 255
G VL+ H KE V + E T + ++ +A+ Q +LR LR A+E
Sbjct: 1068 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1127
Query: 256 AQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER--RDAMYQEE----L 309
+R +Q E++ E++ RE++++ E + AQ + +Q+E E+ R Y E L
Sbjct: 1128 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1187
Query: 310 GG-------QRDLVQAM----KRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRF 358
G +++ +QAM + V E ++++ L + ++ EC RF
Sbjct: 1188 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC--------QRF 1239
Query: 359 SRRY 362
+++Y
Sbjct: 1240 AKQY 1243
Score = 38.9 bits (89), Expect = 0.008
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 27/139 (19%)
Query: 225 TLVARREEQAEVSLQDEIKSLRLG-LRKAEEQAQRQEQLLREQEGE-------------- 269
TL A R+ Q E+S + E LR+ + +A+ +A+ Q R+Q E
Sbjct: 2335 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2394
Query: 270 -------LQALREQ----LSRCQEERAELQAQLEQKQQEAERRDAMYQE-ELGGQRDLVQ 317
L+ R+Q R +E AEL+ + E+ QQEA+ +E + Q L+Q
Sbjct: 2395 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2454
Query: 318 AMKRRVLELIQEKDRLWQR 336
+ + EKD L QR
Sbjct: 2455 ETQALQQSFLSEKDSLLQR 2473
Score = 38.5 bits (88), Expect = 0.011
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEE---QAQRQEQLLREQEGELQALRE 275
Q + E+ ++E+ L+ E ++ R +AEE QA+R+ R Q E + L++
Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087
Query: 276 QLSRCQEERAELQAQLEQKQQEAERRDA 303
+ RA+ QA E+ ++EAE+ A
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQEAA 2115
Score = 37.4 bits (85), Expect = 0.024
Identities = 64/307 (20%), Positives = 121/307 (39%), Gaps = 55/307 (17%)
Query: 77 EKKGESSRKHR------YPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAM 130
EK+ E+ R R + + E + + + D EER + + +G + +
Sbjct: 1826 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1885
Query: 131 GTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQ 190
+++V E E+ + L A ++ G + E E ++ + R + + +RQ
Sbjct: 1886 RQRRQV---EEEI--LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 191 GSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARRE--EQAEVSLQDEIKSLRLG 248
+ A +E+ + + + +L A E Q + +L+ E++ L+
Sbjct: 1941 --------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA- 1984
Query: 249 LRKAEEQAQRQEQLLREQEGELQALREQLSR------------CQEERAELQAQLEQKQQ 296
K EE + +E+ +E +LQ +E + Q++ ELQ L+Q+Q
Sbjct: 1985 --KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Query: 297 ---------EAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPEC 347
EA RR A EE Q + A RR +E E +RL Q + + +
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQA 2099
Query: 348 CVACSKI 354
A K+
Sbjct: 2100 QAAAEKL 2106
Score = 36.6 bits (83), Expect = 0.041
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLR-KAEEQAQRQ----EQLLREQEGELQAL 273
++Q E + QAE Q E R KAEEQA RQ EQ L +Q +
Sbjct: 1613 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672
Query: 274 REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGG-QRDLVQAMKRR 322
+Q ++E L+A+ EQ +Q+ + + +EEL QR+ A ++R
Sbjct: 1673 AQQRLAAEQELIRLRAETEQGEQQRQ----LLEEELARLQREAAAATQKR 1718
Score = 35.8 bits (81), Expect = 0.070
Identities = 30/129 (23%), Positives = 61/129 (47%), Gaps = 19/129 (14%)
Query: 227 VARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC-QEERA 285
+A QA+ + E K L+ ++ +E+ R+E+ + + + ++++E+L + Q A
Sbjct: 1343 LAEAHAQAKAQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1399
Query: 286 ELQAQLEQKQQEAERRDAMYQEEL--------------GGQRDLVQAMKRRVLELIQEKD 331
E+QA+ Q + AER +EE+ GG +QA++ R E +K
Sbjct: 1400 EIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1458
Query: 332 RLWQRLQHL 340
+ + + L
Sbjct: 1459 QAQEEAERL 1467
Score = 33.5 bits (75), Expect = 0.35
Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 24/153 (15%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQA----EVSLQDEIKSLRLGLRKAEEQAQRQE 260
Q + ++ + + + E + EEQA E++ Q+ K +L A+++ ++
Sbjct: 1622 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681
Query: 261 QLLR------EQEGELQALREQLSRCQEE-------RAELQAQLEQKQQEAE-------R 300
+L+R + E + Q L E+L+R Q E R EL+A+L + + E E R
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741
Query: 301 RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
+ + + ++A R EL +E RL
Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1774
Score = 33.5 bits (75), Expect = 0.35
Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 2/107 (1%)
Query: 232 EQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQL 291
EQ L++E+ L+ A ++ Q E L + E++ L +R +EE +
Sbjct: 1694 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 292 EQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
+Q+ + R EE R L + KR+ + E+D QR +
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQ--RQLAEEDAARQRAE 1798
Score = 32.3 bits (72), Expect = 0.77
Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 19/123 (15%)
Query: 228 ARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQA-----LREQLSRCQE 282
+++ +AE E+ LR E+A+RQ QL E +A L E+L+ E
Sbjct: 1753 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1812
Query: 283 E---RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE--LIQEKDRLWQRL 337
+ E + L++K+ E ER + ++E A +RR LE Q K + +RL
Sbjct: 1813 ATRLKTEAEIALKEKEAENERLRRLAEDE---------AFQRRRLEEQAAQHKADIEERL 1863
Query: 338 QHL 340
L
Sbjct: 1864 AQL 1866
Score = 32.0 bits (71), Expect = 1.0
Identities = 40/166 (24%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQ-------EQL 262
KE + Q + V R E +A +E + R+ + Q++RQ +Q
Sbjct: 2029 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2088
Query: 263 LREQ---EGELQALREQLSRCQEERAELQAQLEQ---KQQEA-----ERRDAMYQEELGG 311
EQ + QA E+L + E+ A +AQ EQ +Q++A E+ ++ L
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148
Query: 312 QRDLVQAMKRRVLELIQ---EKDRLWQRLQHLSSMAPECCVACSKI 354
+ + Q + L+L + +K+ L + LQ L + A E S++
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2194
Score = 31.6 bits (70), Expect = 1.3
Identities = 35/151 (23%), Positives = 72/151 (47%), Gaps = 18/151 (11%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSL---QDEIKSLRLGLRKAEEQA----Q 257
QG ++ E ++Q E ++ ++ E L + E++ L +AEE++ +
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1751
Query: 258 RQEQLLREQEGELQALREQLSRCQE--ERAELQAQLEQK-----QQEAERRDAMYQEELG 310
+ +Q L + G + L E+ +R + E A+ Q QL ++ + EAER + E+L
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLA 1808
Query: 311 GQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
+ + +K ++EK+ +RL+ L+
Sbjct: 1809 AIGEATR-LKTEAEIALKEKEAENERLRRLA 1838
Score = 31.2 bits (69), Expect = 1.7
Identities = 26/99 (26%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Query: 211 EDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL 270
+D + Q++ E ++ EQ L ++ R +AEE +R+++ L++ E
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE--- 2545
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEEL 309
Q R+Q EE L+ QL Q +E R + EE+
Sbjct: 2546 QQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEV 2583
Score = 30.0 bits (66), Expect = 3.8
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 263 LREQEGELQALREQLSRCQE-ERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKR 321
+RE EG+LQ L+E L R +R+ +LE Q+A+ +E+L + + + +
Sbjct: 699 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE----KEQLNEYKGHLSGLAK 754
Query: 322 RVLELIQEKDR 332
R ++Q K R
Sbjct: 755 RAKAVVQLKPR 765
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 49.3 bits (116), Expect = 6e-06
Identities = 34/119 (28%), Positives = 62/119 (52%), Gaps = 2/119 (1%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQD-EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALR 274
E +++ E T AR+ Q E L ++ L KA +A+ + +LR+++ + L+
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2404
Query: 275 EQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
E+ + ++ AE A+L QEA R + +E+L QR L + M + ++ +QE RL
Sbjct: 2405 EEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Score = 47.8 bits (112), Expect = 2e-05
Identities = 90/393 (22%), Positives = 145/393 (36%), Gaps = 100/393 (25%)
Query: 24 APKKIPAAYGGPENVQIE-----------DSHTSQAI-----CLQDAPSGQQLAGLPRSQ 67
+P K P G E+V E + TSQ I L+ ++LA R++
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494
Query: 68 QQRHLPFF---LEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQG 124
++ L LEK+ + + H ++ E E KELQ +E E+
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREEAAVDAQ 1549
Query: 125 QGKGAMGTQKEVI--GMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVE 182
Q K ++ + + + EAE+ AE + ++E +Q RG E
Sbjct: 1550 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1609
Query: 183 GAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEI 242
G + R + + A K + E +++ +V ++R+ QAEV L +
Sbjct: 1610 GELQALRARAE-----------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1658
Query: 243 KS-----------------LRLG-------LRKAEEQAQRQEQLL-----REQEGELQAL 273
K+ LRL LR+AE + RQ Q+ R E ELQ+
Sbjct: 1659 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1718
Query: 274 RE---------------------QLSRCQEERAELQAQLEQKQQEAERRDAMYQ------ 306
R QL E RA+ QA+ E+ ++EAER +Q
Sbjct: 1719 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEA 1778
Query: 307 -------EELGGQRDLVQAMKRRVLELIQEKDR 332
EE+ Q+ L QA + E + + R
Sbjct: 1779 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1811
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/136 (22%), Positives = 72/136 (52%), Gaps = 8/136 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEI----KSLRLGLRKAEEQAQRQEQLLREQEGELQ 271
E ++Q E L+ + E+ + Q+++ ++L+ ++ ++E+ + +++ +L+
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2654
Query: 272 AL-REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEK 330
L ++++++ Q+ R E Q Q +Q +QE +R A +E Q + + ++R+ EL Q +
Sbjct: 2655 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714
Query: 331 DRLWQRLQHLSSMAPE 346
QR Q +A E
Sbjct: 2715 Q---QRRQQEELLAEE 2727
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 215 VENPQVQTEVTLVARREEQA-EVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQAL 273
+++ ++QT +E QA + S E SL R E++ + EQL +++ + Q L
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2667
Query: 274 REQLSRCQE----ERAELQAQLEQ---KQQEAERRDAMYQEELGGQRDLVQAMKRRVLEL 326
RE+ R Q+ ER L A +E+ +Q EAE QEEL + L Q +++ L
Sbjct: 2668 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL---QQLEQQRRQQEELL 2724
Query: 327 IQEKDRLWQRLQHL 340
+E RL ++LQ L
Sbjct: 2725 AEENQRLREQLQLL 2738
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/128 (26%), Positives = 62/128 (48%), Gaps = 19/128 (14%)
Query: 220 VQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSR 279
+Q E VA+ E+AE Q + ++ R A E+A+R+ + + + E LR Q
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAER-----AREEAERELERWQLKANEALRLRLQAEE 1787
Query: 280 CQEERAELQAQLEQKQQEAE--------------RRDAMYQEELGGQRDLVQAMKRRVLE 325
++++ QA+ E++++EAE R+ + ++EL QR L + ++ L
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1847
Query: 326 LIQEKDRL 333
QE RL
Sbjct: 1848 AEQELIRL 1855
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/239 (25%), Positives = 100/239 (41%), Gaps = 41/239 (17%)
Query: 127 KGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVS 186
K A T ++ +E E+T + L E E H+K +QRL A
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLE-----ETDHQKNLLDEELQRLKAE--------ATE 2355
Query: 187 GSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLR 246
+RQ S L V +K + +E L+ R ++ + LQ+E + ++
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIE----AENRALILRDKDNTQRFLQEEAEKMK 2411
Query: 247 ------LGLRKAEEQAQRQEQLLREQEGELQALREQL-----------SRCQEERAELQA 289
L A ++A R QL E + +AL E++ +R + E LQ
Sbjct: 2412 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2471
Query: 290 QLEQKQQEAER----RDAMYQ---EELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
Q E Q++A R ++ M Q EE G + ++A ++R LE+ E +RL R+ +S
Sbjct: 2472 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2530
Score = 40.4 bits (93), Expect = 0.003
Identities = 45/184 (24%), Positives = 84/184 (45%), Gaps = 28/184 (15%)
Query: 199 GEPWVLQGHAT--KEDSTVENPQVQTEVTLVARREEQAEVSLQDE-IKSLRLGLRKAEEQ 255
G VL+ H KE V + E T + ++ +A+ Q +LR LR A+E
Sbjct: 1237 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1296
Query: 256 AQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER--RDAMYQEE----L 309
+R +Q E++ E++ RE++++ E + AQ + +Q+E E+ R Y E L
Sbjct: 1297 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1356
Query: 310 GG-------QRDLVQAM----KRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRF 358
G +++ +QAM + V E ++++ L + ++ EC RF
Sbjct: 1357 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC--------QRF 1408
Query: 359 SRRY 362
+++Y
Sbjct: 1409 AKQY 1412
Score = 38.9 bits (89), Expect = 0.008
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 27/139 (19%)
Query: 225 TLVARREEQAEVSLQDEIKSLRLG-LRKAEEQAQRQEQLLREQEGE-------------- 269
TL A R+ Q E+S + E LR+ + +A+ +A+ Q R+Q E
Sbjct: 2504 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2563
Query: 270 -------LQALREQ----LSRCQEERAELQAQLEQKQQEAERRDAMYQE-ELGGQRDLVQ 317
L+ R+Q R +E AEL+ + E+ QQEA+ +E + Q L+Q
Sbjct: 2564 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2623
Query: 318 AMKRRVLELIQEKDRLWQR 336
+ + EKD L QR
Sbjct: 2624 ETQALQQSFLSEKDSLLQR 2642
Score = 38.5 bits (88), Expect = 0.011
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEE---QAQRQEQLLREQEGELQALRE 275
Q + E+ ++E+ L+ E ++ R +AEE QA+R+ R Q E + L++
Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256
Query: 276 QLSRCQEERAELQAQLEQKQQEAERRDA 303
+ RA+ QA E+ ++EAE+ A
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQEAA 2284
Score = 37.4 bits (85), Expect = 0.024
Identities = 64/307 (20%), Positives = 121/307 (39%), Gaps = 55/307 (17%)
Query: 77 EKKGESSRKHR------YPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAM 130
EK+ E+ R R + + E + + + D EER + + +G + +
Sbjct: 1995 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 2054
Query: 131 GTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQ 190
+++V E E+ + L A ++ G + E E ++ + R + + +RQ
Sbjct: 2055 RQRRQV---EEEI--LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 191 GSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARRE--EQAEVSLQDEIKSLRLG 248
+ A +E+ + + + +L A E Q + +L+ E++ L+
Sbjct: 2110 --------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA- 2153
Query: 249 LRKAEEQAQRQEQLLREQEGELQALREQLSR------------CQEERAELQAQLEQKQQ 296
K EE + +E+ +E +LQ +E + Q++ ELQ L+Q+Q
Sbjct: 2154 --KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Query: 297 ---------EAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPEC 347
EA RR A EE Q + A RR +E E +RL Q + + +
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQA 2268
Query: 348 CVACSKI 354
A K+
Sbjct: 2269 QAAAEKL 2275
Score = 36.6 bits (83), Expect = 0.041
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLR-KAEEQAQRQ----EQLLREQEGELQAL 273
++Q E + QAE Q E R KAEEQA RQ EQ L +Q +
Sbjct: 1782 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841
Query: 274 REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGG-QRDLVQAMKRR 322
+Q ++E L+A+ EQ +Q+ + + +EEL QR+ A ++R
Sbjct: 1842 AQQRLAAEQELIRLRAETEQGEQQRQ----LLEEELARLQREAAAATQKR 1887
Score = 35.8 bits (81), Expect = 0.070
Identities = 30/129 (23%), Positives = 61/129 (47%), Gaps = 19/129 (14%)
Query: 227 VARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC-QEERA 285
+A QA+ + E K L+ ++ +E+ R+E+ + + + ++++E+L + Q A
Sbjct: 1512 LAEAHAQAKAQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1568
Query: 286 ELQAQLEQKQQEAERRDAMYQEEL--------------GGQRDLVQAMKRRVLELIQEKD 331
E+QA+ Q + AER +EE+ GG +QA++ R E +K
Sbjct: 1569 EIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1627
Query: 332 RLWQRLQHL 340
+ + + L
Sbjct: 1628 QAQEEAERL 1636
Score = 33.5 bits (75), Expect = 0.35
Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 24/153 (15%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQA----EVSLQDEIKSLRLGLRKAEEQAQRQE 260
Q + ++ + + + E + EEQA E++ Q+ K +L A+++ ++
Sbjct: 1791 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 261 QLLR------EQEGELQALREQLSRCQEE-------RAELQAQLEQKQQEAE-------R 300
+L+R + E + Q L E+L+R Q E R EL+A+L + + E E R
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910
Query: 301 RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
+ + + ++A R EL +E RL
Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1943
Score = 33.5 bits (75), Expect = 0.35
Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 2/107 (1%)
Query: 232 EQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQL 291
EQ L++E+ L+ A ++ Q E L + E++ L +R +EE +
Sbjct: 1863 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 292 EQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
+Q+ + R EE R L + KR+ + E+D QR +
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQ--RQLAEEDAARQRAE 1967
Score = 32.3 bits (72), Expect = 0.77
Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 19/123 (15%)
Query: 228 ARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQA-----LREQLSRCQE 282
+++ +AE E+ LR E+A+RQ QL E +A L E+L+ E
Sbjct: 1922 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1981
Query: 283 E---RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE--LIQEKDRLWQRL 337
+ E + L++K+ E ER + ++E A +RR LE Q K + +RL
Sbjct: 1982 ATRLKTEAEIALKEKEAENERLRRLAEDE---------AFQRRRLEEQAAQHKADIEERL 2032
Query: 338 QHL 340
L
Sbjct: 2033 AQL 2035
Score = 32.0 bits (71), Expect = 1.0
Identities = 40/166 (24%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQ-------EQL 262
KE + Q + V R E +A +E + R+ + Q++RQ +Q
Sbjct: 2198 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2257
Query: 263 LREQ---EGELQALREQLSRCQEERAELQAQLEQ---KQQEA-----ERRDAMYQEELGG 311
EQ + QA E+L + E+ A +AQ EQ +Q++A E+ ++ L
Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317
Query: 312 QRDLVQAMKRRVLELIQ---EKDRLWQRLQHLSSMAPECCVACSKI 354
+ + Q + L+L + +K+ L + LQ L + A E S++
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2363
Score = 31.6 bits (70), Expect = 1.3
Identities = 35/151 (23%), Positives = 72/151 (47%), Gaps = 18/151 (11%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSL---QDEIKSLRLGLRKAEEQA----Q 257
QG ++ E ++Q E ++ ++ E L + E++ L +AEE++ +
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920
Query: 258 RQEQLLREQEGELQALREQLSRCQE--ERAELQAQLEQK-----QQEAERRDAMYQEELG 310
+ +Q L + G + L E+ +R + E A+ Q QL ++ + EAER + E+L
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLA 1977
Query: 311 GQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
+ + +K ++EK+ +RL+ L+
Sbjct: 1978 AIGEATR-LKTEAEIALKEKEAENERLRRLA 2007
Score = 31.2 bits (69), Expect = 1.7
Identities = 26/99 (26%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Query: 211 EDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL 270
+D + Q++ E ++ EQ L ++ R +AEE +R+++ L++ E
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE--- 2714
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEEL 309
Q R+Q EE L+ QL Q +E R + EE+
Sbjct: 2715 QQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEV 2752
Score = 30.0 bits (66), Expect = 3.8
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 263 LREQEGELQALREQLSRCQE-ERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKR 321
+RE EG+LQ L+E L R +R+ +LE Q+A+ +E+L + + + +
Sbjct: 868 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE----KEQLNEYKGHLSGLAK 923
Query: 322 RVLELIQEKDR 332
R ++Q K R
Sbjct: 924 RAKAVVQLKPR 934
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 49.3 bits (116), Expect = 6e-06
Identities = 34/119 (28%), Positives = 62/119 (52%), Gaps = 2/119 (1%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQD-EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALR 274
E +++ E T AR+ Q E L ++ L KA +A+ + +LR+++ + L+
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2245
Query: 275 EQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
E+ + ++ AE A+L QEA R + +E+L QR L + M + ++ +QE RL
Sbjct: 2246 EEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303
Score = 47.8 bits (112), Expect = 2e-05
Identities = 90/393 (22%), Positives = 145/393 (36%), Gaps = 100/393 (25%)
Query: 24 APKKIPAAYGGPENVQIE-----------DSHTSQAI-----CLQDAPSGQQLAGLPRSQ 67
+P K P G E+V E + TSQ I L+ ++LA R++
Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1335
Query: 68 QQRHLPFF---LEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQG 124
++ L LEK+ + + H ++ E E KELQ +E E+
Sbjct: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREEAAVDAQ 1390
Query: 125 QGKGAMGTQKEVI--GMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVE 182
Q K ++ + + + EAE+ AE + ++E +Q RG E
Sbjct: 1391 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1450
Query: 183 GAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEI 242
G + R + + A K + E +++ +V ++R+ QAEV L +
Sbjct: 1451 GELQALRARAE-----------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1499
Query: 243 KS-----------------LRLG-------LRKAEEQAQRQEQLL-----REQEGELQAL 273
K+ LRL LR+AE + RQ Q+ R E ELQ+
Sbjct: 1500 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1559
Query: 274 RE---------------------QLSRCQEERAELQAQLEQKQQEAERRDAMYQ------ 306
R QL E RA+ QA+ E+ ++EAER +Q
Sbjct: 1560 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEA 1619
Query: 307 -------EELGGQRDLVQAMKRRVLELIQEKDR 332
EE+ Q+ L QA + E + + R
Sbjct: 1620 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1652
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/136 (22%), Positives = 72/136 (52%), Gaps = 8/136 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEI----KSLRLGLRKAEEQAQRQEQLLREQEGELQ 271
E ++Q E L+ + E+ + Q+++ ++L+ ++ ++E+ + +++ +L+
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2495
Query: 272 AL-REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEK 330
L ++++++ Q+ R E Q Q +Q +QE +R A +E Q + + ++R+ EL Q +
Sbjct: 2496 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
Query: 331 DRLWQRLQHLSSMAPE 346
QR Q +A E
Sbjct: 2556 Q---QRRQQEELLAEE 2568
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 215 VENPQVQTEVTLVARREEQA-EVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQAL 273
+++ ++QT +E QA + S E SL R E++ + EQL +++ + Q L
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2508
Query: 274 REQLSRCQE----ERAELQAQLEQ---KQQEAERRDAMYQEELGGQRDLVQAMKRRVLEL 326
RE+ R Q+ ER L A +E+ +Q EAE QEEL + L Q +++ L
Sbjct: 2509 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL---QQLEQQRRQQEELL 2565
Query: 327 IQEKDRLWQRLQHL 340
+E RL ++LQ L
Sbjct: 2566 AEENQRLREQLQLL 2579
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/128 (26%), Positives = 62/128 (48%), Gaps = 19/128 (14%)
Query: 220 VQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSR 279
+Q E VA+ E+AE Q + ++ R A E+A+R+ + + + E LR Q
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAER-----AREEAERELERWQLKANEALRLRLQAEE 1628
Query: 280 CQEERAELQAQLEQKQQEAE--------------RRDAMYQEELGGQRDLVQAMKRRVLE 325
++++ QA+ E++++EAE R+ + ++EL QR L + ++ L
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1688
Query: 326 LIQEKDRL 333
QE RL
Sbjct: 1689 AEQELIRL 1696
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/239 (25%), Positives = 100/239 (41%), Gaps = 41/239 (17%)
Query: 127 KGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVS 186
K A T ++ +E E+T + L E E H+K +QRL A
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLE-----ETDHQKNLLDEELQRLKAE--------ATE 2196
Query: 187 GSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLR 246
+RQ S L V +K + +E L+ R ++ + LQ+E + ++
Sbjct: 2197 AARQRSQVEEELFSVRVQMEELSKLKARIE----AENRALILRDKDNTQRFLQEEAEKMK 2252
Query: 247 ------LGLRKAEEQAQRQEQLLREQEGELQALREQL-----------SRCQEERAELQA 289
L A ++A R QL E + +AL E++ +R + E LQ
Sbjct: 2253 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2312
Query: 290 QLEQKQQEAER----RDAMYQ---EELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
Q E Q++A R ++ M Q EE G + ++A ++R LE+ E +RL R+ +S
Sbjct: 2313 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2371
Score = 40.4 bits (93), Expect = 0.003
Identities = 45/184 (24%), Positives = 84/184 (45%), Gaps = 28/184 (15%)
Query: 199 GEPWVLQGHAT--KEDSTVENPQVQTEVTLVARREEQAEVSLQDE-IKSLRLGLRKAEEQ 255
G VL+ H KE V + E T + ++ +A+ Q +LR LR A+E
Sbjct: 1078 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1137
Query: 256 AQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER--RDAMYQEE----L 309
+R +Q E++ E++ RE++++ E + AQ + +Q+E E+ R Y E L
Sbjct: 1138 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1197
Query: 310 GG-------QRDLVQAM----KRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRF 358
G +++ +QAM + V E ++++ L + ++ EC RF
Sbjct: 1198 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC--------QRF 1249
Query: 359 SRRY 362
+++Y
Sbjct: 1250 AKQY 1253
Score = 38.9 bits (89), Expect = 0.008
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 27/139 (19%)
Query: 225 TLVARREEQAEVSLQDEIKSLRLG-LRKAEEQAQRQEQLLREQEGE-------------- 269
TL A R+ Q E+S + E LR+ + +A+ +A+ Q R+Q E
Sbjct: 2345 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2404
Query: 270 -------LQALREQ----LSRCQEERAELQAQLEQKQQEAERRDAMYQE-ELGGQRDLVQ 317
L+ R+Q R +E AEL+ + E+ QQEA+ +E + Q L+Q
Sbjct: 2405 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2464
Query: 318 AMKRRVLELIQEKDRLWQR 336
+ + EKD L QR
Sbjct: 2465 ETQALQQSFLSEKDSLLQR 2483
Score = 38.5 bits (88), Expect = 0.011
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEE---QAQRQEQLLREQEGELQALRE 275
Q + E+ ++E+ L+ E ++ R +AEE QA+R+ R Q E + L++
Sbjct: 2038 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2097
Query: 276 QLSRCQEERAELQAQLEQKQQEAERRDA 303
+ RA+ QA E+ ++EAE+ A
Sbjct: 2098 SAEEQAQARAQAQAAAEKLRKEAEQEAA 2125
Score = 37.4 bits (85), Expect = 0.024
Identities = 64/307 (20%), Positives = 121/307 (39%), Gaps = 55/307 (17%)
Query: 77 EKKGESSRKHR------YPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAM 130
EK+ E+ R R + + E + + + D EER + + +G + +
Sbjct: 1836 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1895
Query: 131 GTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQ 190
+++V E E+ + L A ++ G + E E ++ + R + + +RQ
Sbjct: 1896 RQRRQV---EEEI--LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 191 GSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARRE--EQAEVSLQDEIKSLRLG 248
+ A +E+ + + + +L A E Q + +L+ E++ L+
Sbjct: 1951 --------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA- 1994
Query: 249 LRKAEEQAQRQEQLLREQEGELQALREQLSR------------CQEERAELQAQLEQKQQ 296
K EE + +E+ +E +LQ +E + Q++ ELQ L+Q+Q
Sbjct: 1995 --KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Query: 297 ---------EAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPEC 347
EA RR A EE Q + A RR +E E +RL Q + + +
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQA 2109
Query: 348 CVACSKI 354
A K+
Sbjct: 2110 QAAAEKL 2116
Score = 36.6 bits (83), Expect = 0.041
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLR-KAEEQAQRQ----EQLLREQEGELQAL 273
++Q E + QAE Q E R KAEEQA RQ EQ L +Q +
Sbjct: 1623 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682
Query: 274 REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGG-QRDLVQAMKRR 322
+Q ++E L+A+ EQ +Q+ + + +EEL QR+ A ++R
Sbjct: 1683 AQQRLAAEQELIRLRAETEQGEQQRQ----LLEEELARLQREAAAATQKR 1728
Score = 35.8 bits (81), Expect = 0.070
Identities = 30/129 (23%), Positives = 61/129 (47%), Gaps = 19/129 (14%)
Query: 227 VARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC-QEERA 285
+A QA+ + E K L+ ++ +E+ R+E+ + + + ++++E+L + Q A
Sbjct: 1353 LAEAHAQAKAQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1409
Query: 286 ELQAQLEQKQQEAERRDAMYQEEL--------------GGQRDLVQAMKRRVLELIQEKD 331
E+QA+ Q + AER +EE+ GG +QA++ R E +K
Sbjct: 1410 EIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1468
Query: 332 RLWQRLQHL 340
+ + + L
Sbjct: 1469 QAQEEAERL 1477
Score = 33.5 bits (75), Expect = 0.35
Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 24/153 (15%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQA----EVSLQDEIKSLRLGLRKAEEQAQRQE 260
Q + ++ + + + E + EEQA E++ Q+ K +L A+++ ++
Sbjct: 1632 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691
Query: 261 QLLR------EQEGELQALREQLSRCQEE-------RAELQAQLEQKQQEAE-------R 300
+L+R + E + Q L E+L+R Q E R EL+A+L + + E E R
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751
Query: 301 RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
+ + + ++A R EL +E RL
Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1784
Score = 33.5 bits (75), Expect = 0.35
Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 2/107 (1%)
Query: 232 EQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQL 291
EQ L++E+ L+ A ++ Q E L + E++ L +R +EE +
Sbjct: 1704 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763
Query: 292 EQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
+Q+ + R EE R L + KR+ + E+D QR +
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQ--RQLAEEDAARQRAE 1808
Score = 32.3 bits (72), Expect = 0.77
Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 19/123 (15%)
Query: 228 ARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQA-----LREQLSRCQE 282
+++ +AE E+ LR E+A+RQ QL E +A L E+L+ E
Sbjct: 1763 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1822
Query: 283 E---RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE--LIQEKDRLWQRL 337
+ E + L++K+ E ER + ++E A +RR LE Q K + +RL
Sbjct: 1823 ATRLKTEAEIALKEKEAENERLRRLAEDE---------AFQRRRLEEQAAQHKADIEERL 1873
Query: 338 QHL 340
L
Sbjct: 1874 AQL 1876
Score = 32.0 bits (71), Expect = 1.0
Identities = 40/166 (24%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQ-------EQL 262
KE + Q + V R E +A +E + R+ + Q++RQ +Q
Sbjct: 2039 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2098
Query: 263 LREQ---EGELQALREQLSRCQEERAELQAQLEQ---KQQEA-----ERRDAMYQEELGG 311
EQ + QA E+L + E+ A +AQ EQ +Q++A E+ ++ L
Sbjct: 2099 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158
Query: 312 QRDLVQAMKRRVLELIQ---EKDRLWQRLQHLSSMAPECCVACSKI 354
+ + Q + L+L + +K+ L + LQ L + A E S++
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2204
Score = 31.6 bits (70), Expect = 1.3
Identities = 35/151 (23%), Positives = 72/151 (47%), Gaps = 18/151 (11%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSL---QDEIKSLRLGLRKAEEQA----Q 257
QG ++ E ++Q E ++ ++ E L + E++ L +AEE++ +
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1761
Query: 258 RQEQLLREQEGELQALREQLSRCQE--ERAELQAQLEQK-----QQEAERRDAMYQEELG 310
+ +Q L + G + L E+ +R + E A+ Q QL ++ + EAER + E+L
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLA 1818
Query: 311 GQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
+ + +K ++EK+ +RL+ L+
Sbjct: 1819 AIGEATR-LKTEAEIALKEKEAENERLRRLA 1848
Score = 31.2 bits (69), Expect = 1.7
Identities = 26/99 (26%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Query: 211 EDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL 270
+D + Q++ E ++ EQ L ++ R +AEE +R+++ L++ E
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE--- 2555
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEEL 309
Q R+Q EE L+ QL Q +E R + EE+
Sbjct: 2556 QQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEV 2593
Score = 30.0 bits (66), Expect = 3.8
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 263 LREQEGELQALREQLSRCQE-ERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKR 321
+RE EG+LQ L+E L R +R+ +LE Q+A+ +E+L + + + +
Sbjct: 709 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE----KEQLNEYKGHLSGLAK 764
Query: 322 RVLELIQEKDR 332
R ++Q K R
Sbjct: 765 RAKAVVQLKPR 775
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 49.3 bits (116), Expect = 6e-06
Identities = 34/119 (28%), Positives = 62/119 (52%), Gaps = 2/119 (1%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQD-EIKSLRLGLRKAEEQAQRQEQLLREQEGELQALR 274
E +++ E T AR+ Q E L ++ L KA +A+ + +LR+++ + L+
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2253
Query: 275 EQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
E+ + ++ AE A+L QEA R + +E+L QR L + M + ++ +QE RL
Sbjct: 2254 EEAEKMKQV-AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311
Score = 47.8 bits (112), Expect = 2e-05
Identities = 90/393 (22%), Positives = 145/393 (36%), Gaps = 100/393 (25%)
Query: 24 APKKIPAAYGGPENVQIE-----------DSHTSQAI-----CLQDAPSGQQLAGLPRSQ 67
+P K P G E+V E + TSQ I L+ ++LA R++
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1343
Query: 68 QQRHLPFF---LEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQG 124
++ L LEK+ + + H ++ E E KELQ +E E+
Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREEAAVDAQ 1398
Query: 125 QGKGAMGTQKEVI--GMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVE 182
Q K ++ + + + EAE+ AE + ++E +Q RG E
Sbjct: 1399 QQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAE 1458
Query: 183 GAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEI 242
G + R + + A K + E +++ +V ++R+ QAEV L +
Sbjct: 1459 GELQALRARAE-----------EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1507
Query: 243 KS-----------------LRLG-------LRKAEEQAQRQEQLL-----REQEGELQAL 273
K+ LRL LR+AE + RQ Q+ R E ELQ+
Sbjct: 1508 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1567
Query: 274 RE---------------------QLSRCQEERAELQAQLEQKQQEAERRDAMYQ------ 306
R QL E RA+ QA+ E+ ++EAER +Q
Sbjct: 1568 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEA 1627
Query: 307 -------EELGGQRDLVQAMKRRVLELIQEKDR 332
EE+ Q+ L QA + E + + R
Sbjct: 1628 LRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1660
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/136 (22%), Positives = 72/136 (52%), Gaps = 8/136 (5%)
Query: 216 ENPQVQTEVTLVARREEQAEVSLQDEI----KSLRLGLRKAEEQAQRQEQLLREQEGELQ 271
E ++Q E L+ + E+ + Q+++ ++L+ ++ ++E+ + +++ +L+
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLE 2503
Query: 272 AL-REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEK 330
L ++++++ Q+ R E Q Q +Q +QE +R A +E Q + + ++R+ EL Q +
Sbjct: 2504 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2563
Query: 331 DRLWQRLQHLSSMAPE 346
QR Q +A E
Sbjct: 2564 Q---QRRQQEELLAEE 2576
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/134 (31%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 215 VENPQVQTEVTLVARREEQA-EVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQAL 273
+++ ++QT +E QA + S E SL R E++ + EQL +++ + Q L
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2516
Query: 274 REQLSRCQE----ERAELQAQLEQ---KQQEAERRDAMYQEELGGQRDLVQAMKRRVLEL 326
RE+ R Q+ ER L A +E+ +Q EAE QEEL + L Q +++ L
Sbjct: 2517 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL---QQLEQQRRQQEELL 2573
Query: 327 IQEKDRLWQRLQHL 340
+E RL ++LQ L
Sbjct: 2574 AEENQRLREQLQLL 2587
Score = 40.8 bits (94), Expect = 0.002
Identities = 34/128 (26%), Positives = 62/128 (48%), Gaps = 19/128 (14%)
Query: 220 VQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSR 279
+Q E VA+ E+AE Q + ++ R A E+A+R+ + + + E LR Q
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAER-----AREEAERELERWQLKANEALRLRLQAEE 1636
Query: 280 CQEERAELQAQLEQKQQEAE--------------RRDAMYQEELGGQRDLVQAMKRRVLE 325
++++ QA+ E++++EAE R+ + ++EL QR L + ++ L
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1696
Query: 326 LIQEKDRL 333
QE RL
Sbjct: 1697 AEQELIRL 1704
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/239 (25%), Positives = 100/239 (41%), Gaps = 41/239 (17%)
Query: 127 KGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVS 186
K A T ++ +E E+T + L E E H+K +QRL A
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLE-----ETDHQKNLLDEELQRLKAE--------ATE 2204
Query: 187 GSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLR 246
+RQ S L V +K + +E L+ R ++ + LQ+E + ++
Sbjct: 2205 AARQRSQVEEELFSVRVQMEELSKLKARIE----AENRALILRDKDNTQRFLQEEAEKMK 2260
Query: 247 ------LGLRKAEEQAQRQEQLLREQEGELQALREQL-----------SRCQEERAELQA 289
L A ++A R QL E + +AL E++ +R + E LQ
Sbjct: 2261 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQ 2320
Query: 290 QLEQKQQEAER----RDAMYQ---EELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
Q E Q++A R ++ M Q EE G + ++A ++R LE+ E +RL R+ +S
Sbjct: 2321 QKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2379
Score = 40.4 bits (93), Expect = 0.003
Identities = 45/184 (24%), Positives = 84/184 (45%), Gaps = 28/184 (15%)
Query: 199 GEPWVLQGHAT--KEDSTVENPQVQTEVTLVARREEQAEVSLQDE-IKSLRLGLRKAEEQ 255
G VL+ H KE V + E T + ++ +A+ Q +LR LR A+E
Sbjct: 1086 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1145
Query: 256 AQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAER--RDAMYQEE----L 309
+R +Q E++ E++ RE++++ E + AQ + +Q+E E+ R Y E L
Sbjct: 1146 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1205
Query: 310 GG-------QRDLVQAM----KRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRF 358
G +++ +QAM + V E ++++ L + ++ EC RF
Sbjct: 1206 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC--------QRF 1257
Query: 359 SRRY 362
+++Y
Sbjct: 1258 AKQY 1261
Score = 38.9 bits (89), Expect = 0.008
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 27/139 (19%)
Query: 225 TLVARREEQAEVSLQDEIKSLRLG-LRKAEEQAQRQEQLLREQEGE-------------- 269
TL A R+ Q E+S + E LR+ + +A+ +A+ Q R+Q E
Sbjct: 2353 TLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE 2412
Query: 270 -------LQALREQ----LSRCQEERAELQAQLEQKQQEAERRDAMYQE-ELGGQRDLVQ 317
L+ R+Q R +E AEL+ + E+ QQEA+ +E + Q L+Q
Sbjct: 2413 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ 2472
Query: 318 AMKRRVLELIQEKDRLWQR 336
+ + EKD L QR
Sbjct: 2473 ETQALQQSFLSEKDSLLQR 2491
Score = 38.5 bits (88), Expect = 0.011
Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 3/88 (3%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEE---QAQRQEQLLREQEGELQALRE 275
Q + E+ ++E+ L+ E ++ R +AEE QA+R+ R Q E + L++
Sbjct: 2046 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2105
Query: 276 QLSRCQEERAELQAQLEQKQQEAERRDA 303
+ RA+ QA E+ ++EAE+ A
Sbjct: 2106 SAEEQAQARAQAQAAAEKLRKEAEQEAA 2133
Score = 37.4 bits (85), Expect = 0.024
Identities = 64/307 (20%), Positives = 121/307 (39%), Gaps = 55/307 (17%)
Query: 77 EKKGESSRKHR------YPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAM 130
EK+ E+ R R + + E + + + D EER + + +G + +
Sbjct: 1844 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1903
Query: 131 GTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQ 190
+++V E E+ + L A ++ G + E E ++ + R + + +RQ
Sbjct: 1904 RQRRQV---EEEI--LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 191 GSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARRE--EQAEVSLQDEIKSLRLG 248
+ A +E+ + + + +L A E Q + +L+ E++ L+
Sbjct: 1959 --------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKA- 2002
Query: 249 LRKAEEQAQRQEQLLREQEGELQALREQLSR------------CQEERAELQAQLEQKQQ 296
K EE + +E+ +E +LQ +E + Q++ ELQ L+Q+Q
Sbjct: 2003 --KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060
Query: 297 ---------EAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPEC 347
EA RR A EE Q + A RR +E E +RL Q + + +
Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE---EAERLKQSAEEQAQARAQA 2117
Query: 348 CVACSKI 354
A K+
Sbjct: 2118 QAAAEKL 2124
Score = 36.6 bits (83), Expect = 0.041
Identities = 34/110 (30%), Positives = 52/110 (47%), Gaps = 10/110 (9%)
Query: 219 QVQTEVTLVARREEQAEVSLQDEIKSLRLGLR-KAEEQAQRQ----EQLLREQEGELQAL 273
++Q E + QAE Q E R KAEEQA RQ EQ L +Q +
Sbjct: 1631 RLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690
Query: 274 REQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGG-QRDLVQAMKRR 322
+Q ++E L+A+ EQ +Q+ + + +EEL QR+ A ++R
Sbjct: 1691 AQQRLAAEQELIRLRAETEQGEQQRQ----LLEEELARLQREAAAATQKR 1736
Score = 35.8 bits (81), Expect = 0.070
Identities = 30/129 (23%), Positives = 61/129 (47%), Gaps = 19/129 (14%)
Query: 227 VARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRC-QEERA 285
+A QA+ + E K L+ ++ +E+ R+E+ + + + ++++E+L + Q A
Sbjct: 1361 LAEAHAQAKAQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA 1417
Query: 286 ELQAQLEQKQQEAERRDAMYQEEL--------------GGQRDLVQAMKRRVLELIQEKD 331
E+QA+ Q + AER +EE+ GG +QA++ R E +K
Sbjct: 1418 EIQAKARQAEA-AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1476
Query: 332 RLWQRLQHL 340
+ + + L
Sbjct: 1477 QAQEEAERL 1485
Score = 33.5 bits (75), Expect = 0.35
Identities = 36/153 (23%), Positives = 68/153 (44%), Gaps = 24/153 (15%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQA----EVSLQDEIKSLRLGLRKAEEQAQRQE 260
Q + ++ + + + E + EEQA E++ Q+ K +L A+++ ++
Sbjct: 1640 QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699
Query: 261 QLLR------EQEGELQALREQLSRCQEE-------RAELQAQLEQKQQEAE-------R 300
+L+R + E + Q L E+L+R Q E R EL+A+L + + E E R
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759
Query: 301 RDAMYQEELGGQRDLVQAMKRRVLELIQEKDRL 333
+ + + ++A R EL +E RL
Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARL 1792
Score = 33.5 bits (75), Expect = 0.35
Identities = 26/107 (24%), Positives = 46/107 (42%), Gaps = 2/107 (1%)
Query: 232 EQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQL 291
EQ L++E+ L+ A ++ Q E L + E++ L +R +EE +
Sbjct: 1712 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1771
Query: 292 EQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQ 338
+Q+ + R EE R L + KR+ + E+D QR +
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQ--RQLAEEDAARQRAE 1816
Score = 32.3 bits (72), Expect = 0.77
Identities = 34/123 (27%), Positives = 55/123 (44%), Gaps = 19/123 (15%)
Query: 228 ARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQA-----LREQLSRCQE 282
+++ +AE E+ LR E+A+RQ QL E +A L E+L+ E
Sbjct: 1771 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1830
Query: 283 E---RAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLE--LIQEKDRLWQRL 337
+ E + L++K+ E ER + ++E A +RR LE Q K + +RL
Sbjct: 1831 ATRLKTEAEIALKEKEAENERLRRLAEDE---------AFQRRRLEEQAAQHKADIEERL 1881
Query: 338 QHL 340
L
Sbjct: 1882 AQL 1884
Score = 32.0 bits (71), Expect = 1.0
Identities = 40/166 (24%), Positives = 72/166 (43%), Gaps = 21/166 (12%)
Query: 210 KEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQ-------EQL 262
KE + Q + V R E +A +E + R+ + Q++RQ +Q
Sbjct: 2047 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2106
Query: 263 LREQ---EGELQALREQLSRCQEERAELQAQLEQ---KQQEA-----ERRDAMYQEELGG 311
EQ + QA E+L + E+ A +AQ EQ +Q++A E+ ++ L
Sbjct: 2107 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166
Query: 312 QRDLVQAMKRRVLELIQ---EKDRLWQRLQHLSSMAPECCVACSKI 354
+ + Q + L+L + +K+ L + LQ L + A E S++
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2212
Score = 31.6 bits (70), Expect = 1.3
Identities = 35/151 (23%), Positives = 72/151 (47%), Gaps = 18/151 (11%)
Query: 205 QGHATKEDSTVENPQVQTEVTLVARREEQAEVSL---QDEIKSLRLGLRKAEEQA----Q 257
QG ++ E ++Q E ++ ++ E L + E++ L +AEE++ +
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1769
Query: 258 RQEQLLREQEGELQALREQLSRCQE--ERAELQAQLEQK-----QQEAERRDAMYQEELG 310
+ +Q L + G + L E+ +R + E A+ Q QL ++ + EAER + E+L
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER---VLAEKLA 1826
Query: 311 GQRDLVQAMKRRVLELIQEKDRLWQRLQHLS 341
+ + +K ++EK+ +RL+ L+
Sbjct: 1827 AIGEATR-LKTEAEIALKEKEAENERLRRLA 1856
Score = 31.2 bits (69), Expect = 1.7
Identities = 26/99 (26%), Positives = 46/99 (46%), Gaps = 4/99 (4%)
Query: 211 EDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGEL 270
+D + Q++ E ++ EQ L ++ R +AEE +R+++ L++ E
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE--- 2563
Query: 271 QALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEEL 309
Q R+Q EE L+ QL Q +E R + EE+
Sbjct: 2564 QQRRQQEELLAEENQRLREQL-QLLEEQHRAALAHSEEV 2601
Score = 30.0 bits (66), Expect = 3.8
Identities = 21/71 (29%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 263 LREQEGELQALREQLSRCQE-ERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKR 321
+RE EG+LQ L+E L R +R+ +LE Q+A+ +E+L + + + +
Sbjct: 717 VREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE----KEQLNEYKGHLSGLAK 772
Query: 322 RVLELIQEKDR 332
R ++Q K R
Sbjct: 773 RAKAVVQLKPR 783
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,483,146
Number of Sequences: 37866
Number of extensions: 842162
Number of successful extensions: 14044
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 612
Number of HSP's successfully gapped in prelim test: 700
Number of HSP's that attempted gapping in prelim test: 4746
Number of HSP's gapped (non-prelim): 5608
length of query: 398
length of database: 18,247,518
effective HSP length: 104
effective length of query: 294
effective length of database: 14,309,454
effective search space: 4206979476
effective search space used: 4206979476
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.