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Search of human proteins with 37577159
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|37577159 calcium-sensing receptor [Homo sapiens]
(1078 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|37577159 calcium-sensing receptor [Homo sapiens] 2190 0.0
gi|112807234 G protein-coupled receptor, family C, group 6, memb... 501 e-141
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s... 419 e-117
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens] 417 e-116
gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs... 412 e-115
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens] 409 e-113
gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ... 408 e-113
gi|187960069 glutamate receptor, metabotropic 8 isoform b precur... 402 e-112
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso... 401 e-111
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs... 400 e-111
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur... 398 e-110
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens] 391 e-108
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens] 391 e-108
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso... 390 e-108
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur... 387 e-107
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr... 375 e-103
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre... 374 e-103
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens] 219 1e-56
gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens] 203 6e-52
gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ... 124 6e-28
gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens] 89 3e-17
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 60 1e-08
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 60 1e-08
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 60 1e-08
gi|40255245 G protein-coupled receptor 51 [Homo sapiens] 58 4e-08
gi|8923705 G protein-coupled receptor, family C, group 5, member... 51 5e-06
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform... 50 9e-06
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 50 9e-06
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ... 50 9e-06
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 48 4e-05
>gi|37577159 calcium-sensing receptor [Homo sapiens]
Length = 1078
Score = 2190 bits (5674), Expect = 0.0
Identities = 1078/1078 (100%), Positives = 1078/1078 (100%)
Query: 1 MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC 60
MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
Sbjct: 1 MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC 60
Query: 61 IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI 120
IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
Sbjct: 61 IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI 120
Query: 121 DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF 180
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF
Sbjct: 121 DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF 180
Query: 181 KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS 240
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
Sbjct: 181 KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS 240
Query: 241 ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA 300
ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA
Sbjct: 241 ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA 300
Query: 301 SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL 360
SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL
Sbjct: 301 SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL 360
Query: 361 QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV 420
QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV
Sbjct: 361 QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV 420
Query: 421 YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD 480
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
Sbjct: 421 YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD 480
Query: 481 ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS 540
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
Sbjct: 481 ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS 540
Query: 541 NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA 600
NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA
Sbjct: 541 NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA 600
Query: 601 KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC 660
KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
Sbjct: 601 KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC 660
Query: 661 CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG 720
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
Sbjct: 661 CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG 720
Query: 721 LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT 780
LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT
Sbjct: 721 LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT 780
Query: 781 CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA 840
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
Sbjct: 781 CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA 840
Query: 841 ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS 900
ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS
Sbjct: 841 ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS 900
Query: 901 SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQP 960
SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQP
Sbjct: 901 SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQP 960
Query: 961 RCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHQPLLPLQCGE 1020
RCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHQPLLPLQCGE
Sbjct: 961 RCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHQPLLPLQCGE 1020
Query: 1021 TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS 1078
TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
Sbjct: 1021 TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS 1078
>gi|112807234 G protein-coupled receptor, family C, group 6, member
A [Homo sapiens]
Length = 926
Score = 501 bits (1291), Expect = e-141
Identities = 316/965 (32%), Positives = 508/965 (52%), Gaps = 65/965 (6%)
Query: 7 CWVLLALTWHTSAYGPDQ--RAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYN 64
C+V++ T PD A G II+GGLF IH + + + D RP+ EC+ +
Sbjct: 10 CFVIILAT-SQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSE-DSPRRPQIQECVGFE 67
Query: 65 FRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLN 124
F AMI +IE IN+S LLP + LGY I+DTC V+ A+ ATL F+++
Sbjct: 68 ISVFLQTLAMIHSIEMINNS-TLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRET 126
Query: 125 LDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFL 184
++ C+ S ++P AV+G+ S ++ AV+ +L L +PQV Y S++ +LS+K +F SFL
Sbjct: 127 VEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFL 186
Query: 185 RTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELIS 244
RT+P+D HQ AMA +I+ WNW+G I DDDYGR + F +AE ++CI F E++
Sbjct: 187 RTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLP 246
Query: 245 QYSDEEEIQ-----HVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAW 299
+ + I+ + ++I + VIVVF + L + + NI K+W+AS+ W
Sbjct: 247 AFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNI-NKMWIASDNW 305
Query: 300 ASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCH 359
++++ I +G +GFA + G I F FL+ +H S + E+ C
Sbjct: 306 STATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSAC- 364
Query: 360 LQEGAKGPLPVDTFLRGHEESGDRFSNS--STAFRPLCTGDENISSVETPYIDYTHLRIS 417
+++ + S F++S + A++ + N DY +
Sbjct: 365 ------------AYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLI 412
Query: 418 YNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQV 477
+++ LAV+++ +A++D L C + + W++L L+++ FT+
Sbjct: 413 HSIQLAVFALGYAIRD---------LCQARDCQNPNAFQPWELLGVLKNVTFTDGW-NSF 462
Query: 478 TFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREV 537
FD GDL Y ++ W +G + ++ Y++ + + I +++ + +
Sbjct: 463 HFDAHGDLNTGYDVVLW--KEINGHMTVTKMAEYDL---QNDVFIIPDQETKNEFRNLKQ 517
Query: 538 PFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPD-DFWSNENHT 596
S CS++C G K + CC+EC CP+ Y+++TD C C + W+ T
Sbjct: 518 IQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRST 577
Query: 597 SCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKAT-NRELSYLLL 655
C KE+E+L+W + I L + ++LGI V +F + NTP+VK++ + Y++L
Sbjct: 578 MCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVIL 637
Query: 656 FSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFH 715
F+S+ FFIGEPQD+TC+ RQ FG+SF LCISCIL K+ ++LL F
Sbjct: 638 LCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAF--SFDPKLQ 695
Query: 716 RKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGF 775
+ L L++F CT +Q+VIC +WL A P+ N L +I + C EGS++A G
Sbjct: 696 KFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSL-PRVIILECEEGSILAFGT 754
Query: 776 LIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSA 835
++GY +LA ICF FAFK + EN+NEAKFITF MLI+FI WI+FIP YA+T+GK+V A
Sbjct: 755 MLGYIAILAFICFIFAFKGKY--ENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPA 812
Query: 836 VEVIAILAASFGLLACIFFNKIYIILFKPSRNT---IEEVRCSTAAHAFKVAARATLRRS 892
VE+I IL +++G+L C F K Y+I+ K NT ++ S ++H+ A +
Sbjct: 813 VEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLD 872
Query: 893 NVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLA-LTQQEQQQQPLTLP 951
++S G T + PSSS S + Q + Q Q A + ++ TLP
Sbjct: 873 SMS-------GNVTMTNPSSSGKSAT------WQKSKDLQAQAFAHICRENATSVSKTLP 919
Query: 952 QQQRS 956
+++ S
Sbjct: 920 RKRMS 924
>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
sapiens]
Length = 879
Score = 419 bits (1076), Expect = e-117
Identities = 289/865 (33%), Positives = 436/865 (50%), Gaps = 89/865 (10%)
Query: 29 KGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNF-RGFRWLQAMIFAIEEINSSPAL 87
+GD++LGGLFPI+ + + EC R N RG + L+AM+FAI+EIN L
Sbjct: 36 EGDLVLGGLFPIN----------EKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYL 85
Query: 88 LPNLTLGYRIFDTCNTVSKALEATLSFVAQN--KIDSLNL---DEFCNCSEHIPSTIA-V 141
LP + LG I DTC+ + ALE +L FV + K+D D E+IP IA V
Sbjct: 86 LPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGV 145
Query: 142 VGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADII 201
+G + S VS VANLL LF IPQ+SYAS+S LS+K+++ F RT+P D +QA AMA+I+
Sbjct: 146 IGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEIL 205
Query: 202 EYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVV-EVIQ 260
+F W +V T+A++ DYG GIE F +EA R+ICI +E + + + + V+ E++Q
Sbjct: 206 RFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQ 265
Query: 261 NSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAW-ASSSLIAMPQYFHVVGGTIG 319
A+V+V+F D LI R N W+AS+ W A S+I + HV G I
Sbjct: 266 KPNARVVVLFMRSDDSRELIAAASRAN-ASFTWVASDGWGAQESIIKGSE--HVAYGAIT 322
Query: 320 FALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEE 379
L + + F + + ++P + N + ++FWE+ F C LQ R H
Sbjct: 323 LELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQN-----------KRNH-- 369
Query: 380 SGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIY-TCL 438
R +C D++++ + Y + + N AVY++AHAL + T
Sbjct: 370 ------------RRVC--DKHLAIDSSNYEQESKIMFVVN---AVYAMAHALHKMQRTLC 412
Query: 439 PGRGLFTNGSCADIKKVEAWQVLK-HLRHLNFT------NNMGEQVTFDECGDLVGNYSI 491
P T C +K ++ ++ K +L +NFT + V FD GD +G Y++
Sbjct: 413 PN----TTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNV 468
Query: 492 INWHLSPEDGSIVFKEVGYYNVYAKKG---ERLFINEEKILWSGFSREVPFSNCSRDCLA 548
N F+ VG Y K G E L ++ I WS VP S CS C
Sbjct: 469 FN-----------FQNVGGKYSYLKVGHWAETLSLDVNSIHWS--RNSVPTSQCSDPCAP 515
Query: 549 GTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSW 608
K + G+ CC+ C+ C EY D C C W + T C +++ W
Sbjct: 516 NEMKNMQPGD-VCCWICIPCEPYEYL--ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRW 572
Query: 609 TEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFF 668
+ + I A LG T V+ VFIK NTP+VKA+ REL Y+LLF + + + FF
Sbjct: 573 EDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFF 632
Query: 669 IGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLV 728
I +P C LR+ G SF +C S +L KTN + +F+ + K+ + Q +
Sbjct: 633 IAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFIC 692
Query: 729 FLCTFMQIVICVIWLYTAPPSSYRNQELED-EIIFITCH-EGSLMALGFLIGYTCLLAAI 786
+QIV+ +WL P + R E E + + C+ + S M + + Y +L +
Sbjct: 693 LGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLIS--LTYDVILVIL 750
Query: 787 CFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKF--VSAVEVIAILAA 844
C +AFK+RK PENFNEAKFI F+M I+W++F+P + T + + I++ +
Sbjct: 751 CTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLS 810
Query: 845 SFGLLACIFFNKIYIILFKPSRNTI 869
F +L C+F K++IILF+P +N +
Sbjct: 811 GFVVLGCLFAPKVHIILFQPQKNVV 835
>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
Length = 841
Score = 417 bits (1073), Expect = e-116
Identities = 269/882 (30%), Positives = 435/882 (49%), Gaps = 78/882 (8%)
Query: 5 SCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIR-- 62
SCCW A H++ PD GD +L GLFP+H G ++ RPE C R
Sbjct: 16 SCCW---AFACHSTESSPDFTLP--GDYLLAGLFPLHSGCL----QVRHRPEVTLCDRSC 66
Query: 63 -YNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSK--ALEATLSFVAQNK 119
+N G+ QAM +EEIN+S ALLPN+TLGY+++D C+ + A LS Q+
Sbjct: 67 SFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHH 126
Query: 120 IDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ 179
I+ + + P+ +AV+G + + A LL F +P +SYA+SS LS K Q
Sbjct: 127 IELQG-----DLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQ 181
Query: 180 FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDF 239
+ SFLRTIPND++Q M +++ F W W+ + + DDYG+ G++ +A + ICI F
Sbjct: 182 YPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAF 241
Query: 240 SELI--SQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASE 297
+++ S +E +Q ++ + + A V+VVFSS + +V N+TGK+W+ASE
Sbjct: 242 KDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASE 301
Query: 298 AWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFN 357
AWA S I +G +G A++ +PG + F EE +
Sbjct: 302 AWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAF-------------------EEAY- 341
Query: 358 CHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 417
+ K P P S + LC + + P + + +
Sbjct: 342 --ARADKKAPRPCH-------------KGSWCSSNQLCRECQAFMAHTMPKLKAFSMSSA 386
Query: 418 YNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQV 477
YN Y AVY++AH L + C +G+C+ +V WQ+L+ + ++F + + V
Sbjct: 387 YNAYRAVYAVAHGLHQLLGC-------ASGACSR-GRVYPWQLLEQIHKVHFLLHK-DTV 437
Query: 478 TFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREV 537
F++ D + +Y+II W + + ++ +L INE KI W G +V
Sbjct: 438 AFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPV-----QLNINETKIQWHGKDNQV 492
Query: 538 PFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTS 597
P S CS DCL G ++ ++ G CCFECV C G + +++D C C + W+ E +
Sbjct: 493 PKSVCSSDCLEGHQR-VVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQT 551
Query: 598 CIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFS 657
C + + FL+ E L L + L G+F +TP+V++ L +L+L S
Sbjct: 552 CFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGS 611
Query: 658 LLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFE--AKIPTSFH 715
L S F GEP C LRQ F + F + +SC+ V++ +++++F+ K+PT +H
Sbjct: 612 LAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPTFYH 671
Query: 716 RKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGF 775
W + L V + + Q++IC+ WL P R + ++ + C E + +LGF
Sbjct: 672 -AWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLECTETN--SLGF 728
Query: 776 LIG--YTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFV 833
++ Y LL+ F ++ + LPEN+NEAK +TFS+L F+ WI+F + GK++
Sbjct: 729 ILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYL 788
Query: 834 SAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCS 875
A ++A L++ F K Y+IL +P N+ E + S
Sbjct: 789 PAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQAS 830
>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
[Homo sapiens]
Length = 872
Score = 412 bits (1060), Expect = e-115
Identities = 291/925 (31%), Positives = 445/925 (48%), Gaps = 109/925 (11%)
Query: 11 LALTWHTSAYGPDQRAQK-KGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYN-FRGF 68
L L W A GP ++ +GD++LGGLFP+H K P +C N RG
Sbjct: 10 LLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVH---------QKGGPAE-DCGPVNEHRGI 59
Query: 69 RWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEF 128
+ L+AM+FA++ IN P LLP + LG I D+C+ + ALE L FV + L
Sbjct: 60 QRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRAS------LSRG 113
Query: 129 CNCSEHI------------PSTIA-VVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLS 175
+ S HI P+ I V+G + S VS VANLL LF IPQ+SYAS+S LS
Sbjct: 114 ADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLS 173
Query: 176 NKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDI 235
+K+++ F RT+P D QA AMA+I+ +F W +V T+A++ DYG GIE F EA R+I
Sbjct: 174 DKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNI 233
Query: 236 CIDFSELISQYSDEEEIQHVVE-VIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWL 294
C+ SE + + + VV ++Q +A+V V+F+ D L+ R N + W+
Sbjct: 234 CVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFT-WV 292
Query: 295 ASEAW-ASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWE 353
AS+ W A S++A + G I L + I F + + + P + N + +EFWE
Sbjct: 293 ASDGWGALESVVAGSE--GAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWE 350
Query: 354 ETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTH 413
+ F C +FR ++ +V P+ +
Sbjct: 351 QRFRC-------------------------------SFRQRDCAAHSLRAV--PFEQESK 377
Query: 414 LRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKH-LRHLNFTN- 471
+ N AVY++AHAL +++ L T C ++ V ++ K + ++ F
Sbjct: 378 IMFVVN---AVYAMAHALHNMHRALCPN---TTRLCDAMRPVNGRRLYKDFVLNVKFDAP 431
Query: 472 ----NMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK 527
+ +V FD GD +G Y+I + L G +++VGY+ E L ++
Sbjct: 432 FRPADTHNEVRFDRFGDGIGRYNIFTY-LRAGSGRYRYQKVGYW------AEGLTLDTSL 484
Query: 528 ILWSGFSR-EVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCP 586
I W+ S +P S CS CL K + GE CC+ C+ C EY D C C
Sbjct: 485 IPWASPSAGPLPASRCSEPCLQNEVKSVQPGE-VCCWLCIPCQPYEY--RLDEFTCADCG 541
Query: 587 DDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKAT 646
+W N + T C E++ W + + + A LG T FVLGVF++ TP+VKA+
Sbjct: 542 LGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKAS 601
Query: 647 NRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVF 706
REL Y+LL + C+ + FI +P C LR+ G +F +C S +L KTNR+ +F
Sbjct: 602 GRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIF 661
Query: 707 EAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELE-DEIIFITC 765
+ ++ Q + Q++I V WL P + + E E++ + C
Sbjct: 662 GGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRC 721
Query: 766 HEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAY 825
+ LG L Y LL A+C +AFK+RK PENFNEAKFI F+M I+W++F+P +
Sbjct: 722 NHRDASMLGSL-AYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF 780
Query: 826 ASTYGKFVSAVEVIAILAASFG--LLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKV 883
T + + + + G +L C+F K++IILF+P +N +
Sbjct: 781 YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSH------------ 828
Query: 884 AARATLRRSNVSRKRSSSLGGSTGS 908
T R + + + SSSLG +GS
Sbjct: 829 -RAPTSRFGSAAARASSSLGQGSGS 852
>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
Length = 912
Score = 409 bits (1050), Expect = e-113
Identities = 276/865 (31%), Positives = 437/865 (50%), Gaps = 74/865 (8%)
Query: 30 GDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLP 89
GDI LGGLFP+H G ++ + + +G L+AM+FA++ IN+ P LLP
Sbjct: 47 GDITLGGLFPVH-GRGSEGKPCGELKKE--------KGIHRLEAMLFALDRINNDPDLLP 97
Query: 90 NLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHIPST-----IAVVGA 144
N+TLG RI DTC+ + ALE +L+FV Q I+ + C T + V+GA
Sbjct: 98 NITLGARILDTCSRDTHALEQSLTFV-QALIEKDGTEVRCGSGGPPIITKPERVVGVIGA 156
Query: 145 TGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYF 204
+GS VS VAN+L LF IPQ+SYAS++ LS+ +++ F R +P+D +QA AM DI+
Sbjct: 157 SGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRAL 216
Query: 205 RWNWVGTIAADDDYGRPGIEKFREEA-EERDICIDFSELISQYSDEEEIQHVVE-VIQNS 262
+WN+V T+A++ YG G+E F +++ E+ +CI S I + E ++ +++ S
Sbjct: 217 KWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETS 276
Query: 263 TAKVIVVFSSGPDLEPLIKEIVRRNITGKI-WLASEAWASSSLIAMPQYFHVVGGTIGFA 321
A+ +++F++ D+ +++ R N TG W+ S++W S + + V G +
Sbjct: 277 NARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSK-IAPVLHLEEVAEGAVTIL 335
Query: 322 LKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESG 381
K + GF + + N + EFWE+ F+C L A + G
Sbjct: 336 PKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHAL-------------KKG 382
Query: 382 DRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIYTCL-PG 440
CT E I ++ Y ++ V AVY++ HAL ++ L PG
Sbjct: 383 SHVKK--------CTNRERIGQ-DSAYEQEGKVQF---VIDAVYAMGHALHAMHRDLCPG 430
Query: 441 RGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPED 500
R G C + V+ Q+LK++R++NF+ G VTF+E GD G Y I + L +
Sbjct: 431 RV----GLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQL--RN 484
Query: 501 GSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPT 560
S +K +G + + L + E++ W G +++P S CS C G RK ++G P
Sbjct: 485 DSAEYKVIGSWT------DHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMP- 537
Query: 561 CCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFA 620
CC+ C C +Y + D C CP D EN T C I L W P+ + A
Sbjct: 538 CCWHCEPCTGYQY--QVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLA 595
Query: 621 VLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLR 680
V+GI T FV+ F+++ +TPIVKA+ RELSY+LL + C++++ I EP TC LR
Sbjct: 596 VVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLR 655
Query: 681 QPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICV 740
+ G+ + + +L KTNR+ +FE + ++ Q + F +Q++
Sbjct: 656 RIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGIC 715
Query: 741 IWLYTAPPSS---YRNQELEDEII---FITCHEGSLMALGFLIGYTCLLAAICFFFAFKS 794
+W P S +++Q D + C + S ++L L+GY+ LL C +A K+
Sbjct: 716 VWFVVDPSHSVVDFQDQRTLDPRFARGVLKC-DISDLSLICLLGYSMLLMVTCTVYAIKT 774
Query: 795 RKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKF------VSAVEVIAILAASFGL 848
R +PE FNEAK I F+M IVW++FIP + T + + V L+AS
Sbjct: 775 RGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVS- 833
Query: 849 LACIFFNKIYIILFKPSRNTIEEVR 873
L ++ K+YIILF P +N + R
Sbjct: 834 LGMLYMPKVYIILFHPEQNVPKRKR 858
>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
sapiens]
Length = 877
Score = 408 bits (1048), Expect = e-113
Identities = 280/870 (32%), Positives = 421/870 (48%), Gaps = 76/870 (8%)
Query: 30 GDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSPALLP 89
G + LGGLFP+H AA + + E +G L+AM++A++ +N+ P LLP
Sbjct: 37 GGLTLGGLFPVHARGAAGRACGQLKKE---------QGVHRLEAMLYALDRVNADPELLP 87
Query: 90 NLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEF-CNCSEHIPS--------TIA 140
+ LG R+ DTC+ + ALE LSFV + DE C +P +A
Sbjct: 88 GVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVA 147
Query: 141 VVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADI 200
VVGA+ S VS VAN+L LF IPQ+SYAS++ LS+ ++ F R +P D +QA AM DI
Sbjct: 148 VVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDI 207
Query: 201 IEYFRWNWVGTIAADDDYGRPGIEKFREEAEERD-ICIDFSELISQYSDEEEIQHVVE-V 258
+ WN+V T+A++ +YG G+E F + + E +CI S I + E V+ +
Sbjct: 208 VRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRL 267
Query: 259 IQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGK-IWLASEAWAS--SSLIAMPQYFHVVG 315
++ A+ I++F++ D+ +++ + N+TG +W+ S++W + S ++++ V
Sbjct: 268 METPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLED---VAV 324
Query: 316 GTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDTFLR 375
G I K I GF ++ + N + EFWEE FNC L
Sbjct: 325 GAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTS------------- 371
Query: 376 GHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQDIY 435
SG + +S+ CTG+E I T Y V AVY+IAHAL ++
Sbjct: 372 ----SGTQSDDSTRK----CTGEERIGRDST----YEQEGKVQFVIDAVYAIAHALHSMH 419
Query: 436 TCL-PGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSIINW 494
L PG G C ++ + +L+++R + F + G V F+E GD G Y I +
Sbjct: 420 QALCPGH----TGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQY 475
Query: 495 HLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGI 554
+ S G Y + E L ++ E + WSG EVP S CS C G RK +
Sbjct: 476 QATNGSASS-----GGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKM 530
Query: 555 IEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGI 614
++G P CC+ C C DG Y + D C CP D NHT C + LSW+ P+
Sbjct: 531 VKGVP-CCWHCEAC-DG-YRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAA 587
Query: 615 ALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEPQD 674
L AVLGI T V+ F+++ NTPIV+A+ RELSY+LL + ++ + + EP
Sbjct: 588 PPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGA 647
Query: 675 WTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFM 734
C R+ G+ L S +L KTNR+ +FE + + Q ++ F T +
Sbjct: 648 AVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSL 707
Query: 735 QIVICVIWLYTAPPSS------YRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICF 788
Q+V + WL PP S R + E + C L +G L GY+ LL C
Sbjct: 708 QVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCL-GYSLLLMVTCT 766
Query: 789 FFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGL 848
+A K+R +PE FNEAK I F+M I+W++F+P + T L S L
Sbjct: 767 VYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSL 826
Query: 849 -----LACIFFNKIYIILFKPSRNTIEEVR 873
L ++ K Y+ILF P +N + R
Sbjct: 827 SASVSLGMLYVPKTYVILFHPEQNVQKRKR 856
>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
[Homo sapiens]
Length = 908
Score = 402 bits (1034), Expect = e-112
Identities = 289/940 (30%), Positives = 455/940 (48%), Gaps = 84/940 (8%)
Query: 8 WVLLALT-WHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNF- 65
W+L + H+ Y R GDIILGGLFP+H AK + V C
Sbjct: 23 WILTMMQRTHSQEYAHSIRVD--GDIILGGLFPVH----AKGE------RGVPCGELKKE 70
Query: 66 RGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNL 125
+G L+AM++AI++IN P LL N+TLG RI DTC+ + ALE +L+FV Q I+
Sbjct: 71 KGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV-QALIEKDAS 129
Query: 126 DEFC-NCSEHI---PSTIA-VVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF 180
D C N I P I+ V+GA S VS VAN+L LF IPQ+SYAS++ LS+ ++
Sbjct: 130 DVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189
Query: 181 KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEE-RDICIDF 239
F R +P D +QA AM DI+ WN+V T+A++ +YG G+E F + + E +CI
Sbjct: 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQ 249
Query: 240 SELISQYSDEEEIQHVVE-VIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGK-IWLASE 297
S+ I + E + +++ +++ A+ +++F++ D+ +++ + N +G +W+ S+
Sbjct: 250 SQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309
Query: 298 AWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFN 357
+W S + + Q + G + K I GF + + + N + EFWEE F
Sbjct: 310 SWGSK-IAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFG 368
Query: 358 CHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 417
C L G R S+ CTG E I+ ++ Y ++
Sbjct: 369 CKLGS-----------------HGKRNSHIKK-----CTGLERIAR-DSSYEQEGKVQF- 404
Query: 418 YNVYLAVYSIAHALQDIYTCL-PGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQ 476
V AVYS+A+AL +++ L PG G C + ++ ++L ++R +NF + G
Sbjct: 405 --VIDAVYSMAYALHNMHKDLCPGY----IGLCPRMSTIDGKELLGYIRAVNFNGSAGTP 458
Query: 477 VTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSRE 536
VTF+E GD G Y I + ++ + S +K +G++ +L + E + W+
Sbjct: 459 VTFNENGDAPGRYDIFQYQITNK--STEYKVIGHWT------NQLHLKVEDMQWAHREHT 510
Query: 537 VPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHT 596
P S CS C G RK ++G P CC+ C C Y+ + D +C CP D N N T
Sbjct: 511 HPASVCSLPCKPGERKKTVKGVP-CCWHCERCEG--YNYQVDELSCELCPLDQRPNMNRT 567
Query: 597 SCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLF 656
C I L W P+ + A+LGI T FV+ F+++ +TPIV+A+ RELSY+LL
Sbjct: 568 GCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLT 627
Query: 657 SLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHR 716
+ C+S + I P C R+ G+ + +L KTNR+ +FE +
Sbjct: 628 GIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAP 687
Query: 717 KWWGLNLQFLLVFLCTFMQIVICVIWLYTAPP------SSYRNQELEDEIIFITCHEGSL 770
K+ Q ++ F +Q++ +W PP R + E + C + S
Sbjct: 688 KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKC-DISD 746
Query: 771 MALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYG 830
++L +GY+ LL C +A K+R +PE FNEAK I F+M I+W++FIP + T
Sbjct: 747 LSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQ 806
Query: 831 KFVSAVEVIAILAASFGL-----LACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAA 885
L S L L ++ K+YII+F P +N + R +FK
Sbjct: 807 SAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKR------SFKAVV 860
Query: 886 RATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFP 925
A +S + +K + G S S+ + S S FP
Sbjct: 861 TAATMQSKLIQKGNDRPNGEVKSELCESLETNSKSSVEFP 900
>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
[Homo sapiens]
Length = 915
Score = 401 bits (1030), Expect = e-111
Identities = 289/948 (30%), Positives = 441/948 (46%), Gaps = 91/948 (9%)
Query: 1 MAFYSCCWVLLALTWHTSAYGPDQRAQK----KGDIILGGLFPIHFGVAAKDQDLKSRPE 56
M F C +L +A G + A +GD+ LGGLFP+H P
Sbjct: 14 MKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVH----------AKGPS 63
Query: 57 SVEC---IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLS 113
V C R N G L+AM++A+++INS P LLPN+TLG RI DTC+ + ALE +L+
Sbjct: 64 GVPCGDIKREN--GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLT 121
Query: 114 FVAQNKIDSLNLDEFCNCSE-----HIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYA 168
FV Q I D C E + V+GA+GS VS VAN+L LF IPQ+SYA
Sbjct: 122 FV-QALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA 180
Query: 169 SSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFRE 228
S++ LS+ ++ F R +P D QA AM DI++ WN+V T+A++ YG G+E F +
Sbjct: 181 STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ 240
Query: 229 EAEERD-ICIDFSELISQYSDEEEIQH---VVEVIQNSTAKVIVVFSSGPDLEPLIKEIV 284
++E +CI S I Q + I + +++ ++ +V+F++ D++ ++
Sbjct: 241 ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK 300
Query: 285 RRNITGK-IWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSV 343
R + G +W+ S++W S + + Q+ + G I K + GF + +
Sbjct: 301 RADQVGHFLWVGSDSWGSK-INPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNR 359
Query: 344 HNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISS 403
N + E+WEE FNC L T +E DR CTG E I
Sbjct: 360 RNVWFAEYWEENFNCKL-----------TISGSKKEDTDR----------KCTGQERIGK 398
Query: 404 VETPYIDYTHLRISYNVYLAVYSIAHALQDIYT--CLPGRGLFTNGSCADIKKVEAWQVL 461
++ Y ++ V AVY++AHAL + C RG+ C ++++ ++L
Sbjct: 399 -DSNYEQEGKVQF---VIDAVYAMAHALHHMNKDLCADYRGV-----CPEMEQAGGKKLL 449
Query: 462 KHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERL 521
K++R++NF + G V F++ GD G Y I + + Y + + + L
Sbjct: 450 KYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNP-------GYRLIGQWTDEL 502
Query: 522 FINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASA 581
+N E + W RE+P S C+ C G RK +G P CC+ C C DG Y + D
Sbjct: 503 QLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP-CCWTCEPC-DG-YQYQFDEMT 559
Query: 582 CNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTP 641
C CP D NEN T C I L W P+ + A+LGI T FV+ FI++ +TP
Sbjct: 560 CQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTP 619
Query: 642 IVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNR 701
IV+A+ RELSY+LL + C+ + I +P C R+ G+ + + +L KTNR
Sbjct: 620 IVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNR 679
Query: 702 VLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPS------SYRNQE 755
+ +FE + + Q + +Q++ IW PP+ ++
Sbjct: 680 IYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMN 739
Query: 756 LEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFF 815
E + C L + L GY+ LL C +A K+R +PENFNEAK I F+M
Sbjct: 740 PEQARGVLKCDITDLQIICSL-GYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTC 798
Query: 816 IVWISFIPAYASTYGKFVSAVEVIAILAASFGL-----LACIFFNKIYIILFKPSRNTIE 870
IVW++FIP + T L S L L ++ K+YII+F P N +
Sbjct: 799 IVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQK 858
Query: 871 EVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKS 918
R +FK A S +S K S G + ++ S
Sbjct: 859 RKR------SFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS 900
>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
[Homo sapiens]
Length = 922
Score = 400 bits (1029), Expect = e-111
Identities = 288/934 (30%), Positives = 437/934 (46%), Gaps = 91/934 (9%)
Query: 1 MAFYSCCWVLLALTWHTSAYGPDQRAQK----KGDIILGGLFPIHFGVAAKDQDLKSRPE 56
M F C +L +A G + A +GD+ LGGLFP+H P
Sbjct: 14 MKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVH----------AKGPS 63
Query: 57 SVEC---IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLS 113
V C R N G L+AM++A+++INS P LLPN+TLG RI DTC+ + ALE +L+
Sbjct: 64 GVPCGDIKREN--GIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLT 121
Query: 114 FVAQNKIDSLNLDEFCNCSE-----HIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYA 168
FV Q I D C E + V+GA+GS VS VAN+L LF IPQ+SYA
Sbjct: 122 FV-QALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA 180
Query: 169 SSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFRE 228
S++ LS+ ++ F R +P D QA AM DI++ WN+V T+A++ YG G+E F +
Sbjct: 181 STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ 240
Query: 229 EAEERD-ICIDFSELISQYSDEEEIQH---VVEVIQNSTAKVIVVFSSGPDLEPLIKEIV 284
++E +CI S I Q + I + +++ ++ +V+F++ D++ ++
Sbjct: 241 ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK 300
Query: 285 RRNITGK-IWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSV 343
R + G +W+ S++W S + + Q+ + G I K + GF + +
Sbjct: 301 RADQVGHFLWVGSDSWGSK-INPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNR 359
Query: 344 HNGFAKEFWEETFNCHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISS 403
N + E+WEE FNC L T +E DR CTG E I
Sbjct: 360 RNVWFAEYWEENFNCKL-----------TISGSKKEDTDR----------KCTGQERIGK 398
Query: 404 VETPYIDYTHLRISYNVYLAVYSIAHALQDIYT--CLPGRGLFTNGSCADIKKVEAWQVL 461
++ Y ++ V AVY++AHAL + C RG+ C ++++ ++L
Sbjct: 399 -DSNYEQEGKVQF---VIDAVYAMAHALHHMNKDLCADYRGV-----CPEMEQAGGKKLL 449
Query: 462 KHLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERL 521
K++R++NF + G V F++ GD G Y I + + Y + + + L
Sbjct: 450 KYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNP-------GYRLIGQWTDEL 502
Query: 522 FINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASA 581
+N E + W RE+P S C+ C G RK +G P CC+ C C DG Y + D
Sbjct: 503 QLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTP-CCWTCEPC-DG-YQYQFDEMT 559
Query: 582 CNKCPDDFWSNENHTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTP 641
C CP D NEN T C I L W P+ + A+LGI T FV+ FI++ +TP
Sbjct: 560 CQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTP 619
Query: 642 IVKATNRELSYLLLFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNR 701
IV+A+ RELSY+LL + C+ + I +P C R+ G+ + + +L KTNR
Sbjct: 620 IVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNR 679
Query: 702 VLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPS------SYRNQE 755
+ +FE + + Q + +Q++ IW PP+ ++
Sbjct: 680 IYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMN 739
Query: 756 LEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFF 815
E + C L + L GY+ LL C +A K+R +PENFNEAK I F+M
Sbjct: 740 PEQARGVLKCDITDLQIICSL-GYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTC 798
Query: 816 IVWISFIPAYASTYGKFVSAVEVIAILAASFGL-----LACIFFNKIYIILFKPSRNTIE 870
IVW++FIP + T L S L L ++ K+YII+F P N +
Sbjct: 799 IVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQK 858
Query: 871 EVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGG 904
R +FK A S +S K S G
Sbjct: 859 RKR------SFKAVVTAATMSSRLSHKPSDRPNG 886
>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
[Homo sapiens]
Length = 908
Score = 398 bits (1023), Expect = e-110
Identities = 286/935 (30%), Positives = 454/935 (48%), Gaps = 84/935 (8%)
Query: 8 WVLLALT-WHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNF- 65
W+L + H+ Y R GDIILGGLFP+H AK + V C
Sbjct: 23 WILTMMQRTHSQEYAHSIRVD--GDIILGGLFPVH----AKGE------RGVPCGELKKE 70
Query: 66 RGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNL 125
+G L+AM++AI++IN P LL N+TLG RI DTC+ + ALE +L+FV Q I+
Sbjct: 71 KGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV-QALIEKDAS 129
Query: 126 DEFC-NCSEHI---PSTIA-VVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF 180
D C N I P I+ V+GA S VS VAN+L LF IPQ+SYAS++ LS+ ++
Sbjct: 130 DVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189
Query: 181 KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEE-RDICIDF 239
F R +P D +QA AM DI+ WN+V T+A++ +YG G+E F + + E +CI
Sbjct: 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQ 249
Query: 240 SELISQYSDEEEIQHVVE-VIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGK-IWLASE 297
S+ I + E + +++ +++ A+ +++F++ D+ +++ + N +G +W+ S+
Sbjct: 250 SQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309
Query: 298 AWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFN 357
+W S + + Q + G + K I GF + + + N + EFWEE F
Sbjct: 310 SWGSK-IAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFG 368
Query: 358 CHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 417
C L G R S+ CTG E I+ ++ Y ++
Sbjct: 369 CKLGS-----------------HGKRNSHIKK-----CTGLERIAR-DSSYEQEGKVQF- 404
Query: 418 YNVYLAVYSIAHALQDIYTCL-PGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQ 476
V AVYS+A+AL +++ L PG G C + ++ ++L ++R +NF + G
Sbjct: 405 --VIDAVYSMAYALHNMHKDLCPGY----IGLCPRMSTIDGKELLGYIRAVNFNGSAGTP 458
Query: 477 VTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSRE 536
VTF+E GD G Y I + ++ + S +K +G++ +L + E + W+
Sbjct: 459 VTFNENGDAPGRYDIFQYQITNK--STEYKVIGHWT------NQLHLKVEDMQWAHREHT 510
Query: 537 VPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHT 596
P S CS C G RK ++G P CC+ C C Y+ + D +C CP D N N T
Sbjct: 511 HPASVCSLPCKPGERKKTVKGVP-CCWHCERCEG--YNYQVDELSCELCPLDQRPNMNRT 567
Query: 597 SCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLF 656
C I L W P+ + A+LGI T FV+ F+++ +TPIV+A+ RELSY+LL
Sbjct: 568 GCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLT 627
Query: 657 SLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHR 716
+ C+S + I P C R+ G+ + +L KTNR+ +FE +
Sbjct: 628 GIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAP 687
Query: 717 KWWGLNLQFLLVFLCTFMQIVICVIWLYTAPP------SSYRNQELEDEIIFITCHEGSL 770
K+ Q ++ F +Q++ +W PP R + E + C + S
Sbjct: 688 KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKC-DISD 746
Query: 771 MALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYG 830
++L +GY+ LL C +A K+R +PE FNEAK I F+M I+W++FIP + T
Sbjct: 747 LSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQ 806
Query: 831 KFVSAVEVIAILAASFGL-----LACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAA 885
L S L L ++ K+YII+F P +N + R +FK
Sbjct: 807 SAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKR------SFKAVV 860
Query: 886 RATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNS 920
A +S + +K + G S S+ + ++S
Sbjct: 861 TAATMQSKLIQKGNDRPNGEVKSELCESLETNTSS 895
>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
Length = 852
Score = 391 bits (1005), Expect = e-108
Identities = 264/878 (30%), Positives = 421/878 (47%), Gaps = 77/878 (8%)
Query: 8 WVLLALTWHTSAYGP---DQRAQKKGDIILGGLFPIHFGVAAKDQDLKSR--PESVECIR 62
W LL H P Q+ + KGD +LGGLFP+ A++ L+SR P S C R
Sbjct: 12 WALL----HPGTGAPLCLSQQLRMKGDYVLGGLFPLG---EAEEAGLRSRTRPSSPVCTR 64
Query: 63 YNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDS 122
++ G W AM A+EEIN+ LLP L LGY +FDTC+ A++ +L F+A K S
Sbjct: 65 FSSNGLLWALAMKMAVEEINNKSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLA--KAGS 122
Query: 123 LNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKS 182
++ +CN +++ P +AV+G S ++ F +PQVSY +S LLS + F S
Sbjct: 123 RDIAAYCNYTQYQPRVLAVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPS 182
Query: 183 FLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSEL 242
F RT+P+D Q TA A++++ F WNWV + +DD+YGR G+ F A R ICI L
Sbjct: 183 FFRTVPSDRVQLTAAAELLQEFGWNWVAALGSDDEYGRQGLSIFSALAAARGICIAHEGL 242
Query: 243 I----SQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEA 298
+ + S ++Q V+ + S+ +V+++F+S L + ++ K+W+ASEA
Sbjct: 243 VPLPRADDSRLGKVQDVLHQVNQSSVQVVLLFASVHAAHALFNYSISSRLSPKVWVASEA 302
Query: 299 WASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNC 358
W +S L+ +G +GF + Q+ F +++ K H + F E
Sbjct: 303 WLTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFPQYV-KTHLALATDPAFCSALGERE--- 358
Query: 359 HLQEGAKGPLPVDTFLRGHEES--GDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRI 416
+G EE G R C +N+S+ H +
Sbjct: 359 ----------------QGLEEDVVGQRCPQCD------CITLQNVSA------GLNHHQ- 389
Query: 417 SYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQ 476
+++VY AVYS+A AL + C C V+ WQ+L+++ +L F + G
Sbjct: 390 TFSVYAAVYSVAQALHNTLQC-------NASGCPAQDPVKPWQLLENMYNLTF-HVGGLP 441
Query: 477 VTFDECGDLVGNYSIINWHLSPEDGSIV-FKEVGYYNVYAKKGERLFINEEKILWSGFSR 535
+ FD G++ Y + W GS+ +VG +N + + ERL KI W
Sbjct: 442 LRFDSSGNVDMEYDLKLW---VWQGSVPRLHDVGRFN-GSLRTERL-----KIRWHTSDN 492
Query: 536 EVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENH 595
+ P S CSR C G + ++G +CC++CV+C G Y D AC C D WS E
Sbjct: 493 QKPVSRCSRQCQEGQVRR-VKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQDEWSPERS 551
Query: 596 TSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLL 655
T C + FL+W EP + L L L + L LG+F+ R++P+V+A+ L+ L
Sbjct: 552 TRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPLACFGL 611
Query: 656 FSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFH 715
L S L F G+P C +QP + C+S + ++ + + E+++P S+
Sbjct: 612 VCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLTGCLSTLFLQAAEIFV--ESELPLSWA 669
Query: 716 RKWWGL---NLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMA 772
+ G +L+V L +++ +C +L PP + + + C S ++
Sbjct: 670 DRLSGCLRGPWAWLVVLLAMLVEVALCTWYLVAFPPEVVTDWHMLPTEALVHCRTRSWVS 729
Query: 773 LGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKF 832
G LA +CF F R P +N A+ +TF+ML +FI W+SF+P A+
Sbjct: 730 FGLAHATNATLAFLCFLGTFLVRSQPGRYNRARGLTFAMLAYFITWVSFVPLLANVQVVL 789
Query: 833 VSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIE 870
AV++ A+L G+LA + Y+++ +P NT E
Sbjct: 790 RPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLNTPE 827
>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
Length = 839
Score = 391 bits (1005), Expect = e-108
Identities = 266/877 (30%), Positives = 431/877 (49%), Gaps = 85/877 (9%)
Query: 8 WVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFR- 66
WVL ++ Y P GD +LGGLF +H + K + + C Y +
Sbjct: 16 WVLAEPAENSDFYLP-------GDYLLGGLFSLHANM--KGIVHLNFLQVPMCKEYEVKV 66
Query: 67 -GFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNL 125
G+ +QAM FA+EEIN+ +LLP + LGY I D C +S ++ L F+A + L +
Sbjct: 67 IGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCY-ISNNVQPVLYFLAHED-NLLPI 124
Query: 126 DEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLR 185
E + S +I +AV+G S VAN L LF +PQ++Y++ S L +K +F + LR
Sbjct: 125 QE--DYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLR 182
Query: 186 TIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELI-- 243
T P+ +H AM ++ +FRWNW+ + + D YGR + E RDICI F E +
Sbjct: 183 TTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPT 242
Query: 244 ---SQYSDEEEIQHVVEVI---QNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASE 297
+Q EE Q +V ++ Q STA+V+VVFS L E++R+N TG +W+ASE
Sbjct: 243 LQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASE 302
Query: 298 AWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFN 357
+WA ++ +G +G +++ IPGF EF +E+ +
Sbjct: 303 SWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEF---------------REWGPQA-- 345
Query: 358 CHLQEGAKGPLPVDTFLRGH--EESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLR 415
GP P+ + + + D N++ +F + + + R
Sbjct: 346 --------GPPPLSRTSQSYTCNQECDNCLNATLSFNTI--------------LRLSGER 383
Query: 416 ISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGE 475
+ Y+VY AVY++AHAL + C + S + V WQ+L+ + +NFT +
Sbjct: 384 VVYSVYSAVYAVAHALHSLLGC--------DKSTCTKRVVYPWQLLEEIWKVNFTL-LDH 434
Query: 476 QVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSR 535
Q+ FD GD+ + I+ W F+ V Y +R N + I W +
Sbjct: 435 QIFFDPQGDVALHLEIVQWQWDRSQNP--FQSVASYYPL----QRQLKNIQDISWHTINN 488
Query: 536 EVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDET-DASACNKCPDDFWSNEN 594
+P S CS+ C +G +K + G CCFEC++C G + + T D C CP++ WS ++
Sbjct: 489 TIPMSMCSKRCQSGQKKKPV-GIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQS 547
Query: 595 HTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLL 654
TSC +++ FL W E IA+ L A LG T +L +F + TPIV++ + +L+
Sbjct: 548 ETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLM 607
Query: 655 LFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFE--AKIPT 712
L LL + ++G P+ TC RQ F + F +CISCI V++ +++ F+ ++ P
Sbjct: 608 LTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPR 667
Query: 713 SFHRKWWGLNLQFLLVFLCTFMQIVICVI-WLYTAPPSSYRNQELEDEIIFITCHEGSLM 771
++ W ++ + T +++VI VI L T + R + +I ++C+
Sbjct: 668 AY-SYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRN 726
Query: 772 ALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGK 831
+L F LL+ + F FA+ ++LP N+NEAKFIT SM +F +S ++ G
Sbjct: 727 SLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGV 786
Query: 832 FVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNT 868
V+ V+++ + + F K Y+ILF P RNT
Sbjct: 787 LVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNT 823
>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
[Homo sapiens]
Length = 1180
Score = 390 bits (1001), Expect = e-108
Identities = 276/923 (29%), Positives = 451/923 (48%), Gaps = 89/923 (9%)
Query: 18 SAYGPDQR--AQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMI 75
SA ++R A GDII+G LF +H K +R + G + ++AM+
Sbjct: 19 SAQSSERRVVAHMPGDIIIGALFSVHHQPTVD----KVHERKCGAVREQY-GIQRVEAML 73
Query: 76 FAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHI 135
+E INS P LLPN+TLG I D+C + ALE ++ F+ + I S + C +
Sbjct: 74 HTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGS 133
Query: 136 PST-------IAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIP 188
S+ + V+G S V+ V NLL LF IPQ++Y+++S LS+K FK F+R +P
Sbjct: 134 SSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVP 193
Query: 189 NDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSD 248
+D QA AM DI++ + W +V + + +YG G+E F++ + + ICI S I +
Sbjct: 194 SDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAG 253
Query: 249 EEEIQHVVEVIQN--STAKVIVVFSSGPDLEPLIKEIVRRNITGK-IWLASEAWASSSLI 305
E+ +++ + + A+V+ F G + L+ + R + G+ + L S+ WA +
Sbjct: 254 EQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDV 313
Query: 306 AMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAK 365
VGG I L++ + F ++ K+ P + N + +EFW+ F C L
Sbjct: 314 TDGYQREAVGG-ITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRL----- 367
Query: 366 GPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVY 425
+ F ++ + C +++T ++ + + N A+Y
Sbjct: 368 ----------------EGFPQENSKYNKTCNSS---LTLKTHHVQDSKMGFVIN---AIY 405
Query: 426 SIAHALQDIYTCL-PGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGD 484
S+A+ L ++ L PG G C +K ++ ++L+ L NFT G+ + FDE GD
Sbjct: 406 SMAYGLHNMQMSLCPGYA----GLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGD 461
Query: 485 LVGNYSIINWHLSPEDGSIVFKEVG-----YYNVYAKKGERLFINEEKILWSGFSREVPF 539
G Y I+N FKE+G Y NV + L ++++++ WS S +
Sbjct: 462 SPGRYEIMN-----------FKEMGKDYFDYINVGSWDNGELKMDDDEV-WSKKSNIIR- 508
Query: 540 SNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCI 599
S CS C G K I +GE +CC+ C C + EY D C C W ++ T C
Sbjct: 509 SVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEY--VFDEYTCKACQLGSWPTDDLTGCD 566
Query: 600 AKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLL 659
+++L W +P IA +FA LG+ T FV VFI +R+TP+VK+++REL Y++L +
Sbjct: 567 LIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGIC 626
Query: 660 CCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVF---EAKIPTSFHR 716
+ + I +P+ C L++ G+S + S ++ KTNR+ + + KI T R
Sbjct: 627 LGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPR 686
Query: 717 KWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFL 776
+ Q ++ F+ +Q+ I V PP + E +++ C+ +L + L
Sbjct: 687 -FMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIRE-VYLICNTTNLGVVTPL 744
Query: 777 IGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAV 836
GY LL C F+AFK+R +P NFNEAK+I F+M I+W++F+P Y + K ++
Sbjct: 745 -GYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMC 803
Query: 837 EVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSR 896
+++ A L C+F K+YIIL KP RN ST V +S+ +
Sbjct: 804 FSVSLSATV--ALGCMFVPKVYIILAKPERNVRSAFTTSTV-----VRMHVGDGKSSSAA 856
Query: 897 KRSSSL------GGSTGSTPSSS 913
RSSSL GS+G T SS+
Sbjct: 857 SRSSSLVNLWKRRGSSGETLSSN 879
>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
[Homo sapiens]
Length = 1212
Score = 387 bits (995), Expect = e-107
Identities = 274/919 (29%), Positives = 448/919 (48%), Gaps = 89/919 (9%)
Query: 18 SAYGPDQR--AQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMI 75
SA ++R A GDII+G LF +H K +R + G + ++AM+
Sbjct: 19 SAQSSERRVVAHMPGDIIIGALFSVHHQPTVD----KVHERKCGAVREQY-GIQRVEAML 73
Query: 76 FAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCSEHI 135
+E INS P LLPN+TLG I D+C + ALE ++ F+ + I S + C +
Sbjct: 74 HTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGS 133
Query: 136 PST-------IAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIP 188
S+ + V+G S V+ V NLL LF IPQ++Y+++S LS+K FK F+R +P
Sbjct: 134 SSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVP 193
Query: 189 NDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSD 248
+D QA AM DI++ + W +V + + +YG G+E F++ + + ICI S I +
Sbjct: 194 SDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAG 253
Query: 249 EEEIQHVVEVIQN--STAKVIVVFSSGPDLEPLIKEIVRRNITGK-IWLASEAWASSSLI 305
E+ +++ + + A+V+ F G + L+ + R + G+ + L S+ WA +
Sbjct: 254 EQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDV 313
Query: 306 AMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAK 365
VGG I L++ + F ++ K+ P + N + +EFW+ F C L
Sbjct: 314 TDGYQREAVGG-ITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRL----- 367
Query: 366 GPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVY 425
+ F ++ + C +++T ++ + + N A+Y
Sbjct: 368 ----------------EGFPQENSKYNKTCNSS---LTLKTHHVQDSKMGFVIN---AIY 405
Query: 426 SIAHALQDIYTCL-PGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGD 484
S+A+ L ++ L PG G C +K ++ ++L+ L NFT G+ + FDE GD
Sbjct: 406 SMAYGLHNMQMSLCPGYA----GLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGD 461
Query: 485 LVGNYSIINWHLSPEDGSIVFKEVG-----YYNVYAKKGERLFINEEKILWSGFSREVPF 539
G Y I+N FKE+G Y NV + L ++++++ WS S +
Sbjct: 462 SPGRYEIMN-----------FKEMGKDYFDYINVGSWDNGELKMDDDEV-WSKKSNIIR- 508
Query: 540 SNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCI 599
S CS C G K I +GE +CC+ C C + EY D C C W ++ T C
Sbjct: 509 SVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEY--VFDEYTCKACQLGSWPTDDLTGCD 566
Query: 600 AKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLL 659
+++L W +P IA +FA LG+ T FV VFI +R+TP+VK+++REL Y++L +
Sbjct: 567 LIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGIC 626
Query: 660 CCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVF---EAKIPTSFHR 716
+ + I +P+ C L++ G+S + S ++ KTNR+ + + KI T R
Sbjct: 627 LGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPR 686
Query: 717 KWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFL 776
+ Q ++ F+ +Q+ I V PP + E +++ C+ +L + L
Sbjct: 687 -FMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIRE-VYLICNTTNLGVVTPL 744
Query: 777 IGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAV 836
GY LL C F+AFK+R +P NFNEAK+I F+M I+W++F+P Y + K ++
Sbjct: 745 -GYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMC 803
Query: 837 EVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSR 896
+++ A L C+F K+YIIL KP RN ST V +S+ +
Sbjct: 804 FSVSLSATV--ALGCMFVPKVYIILAKPERNVRSAFTTSTV-----VRMHVGDGKSSSAA 856
Query: 897 KRSSSL------GGSTGST 909
RSSSL GS+G T
Sbjct: 857 SRSSSLVNLWKRRGSSGET 875
>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
precursor [Homo sapiens]
Length = 1194
Score = 375 bits (963), Expect = e-103
Identities = 263/917 (28%), Positives = 440/917 (47%), Gaps = 70/917 (7%)
Query: 26 AQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSP 85
A+ GD+I+G LF +H A+ + E IR + G + ++AM +++IN+ P
Sbjct: 39 ARMDGDVIIGALFSVHHQPPAEKVPERKCGE----IREQY-GIQRVEAMFHTLDKINADP 93
Query: 86 ALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCN-C---SEHIPS---- 137
LLPN+TLG I D+C S ALE ++ F+ + I + + N C + +P
Sbjct: 94 VLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK 153
Query: 138 --TIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQAT 195
V+G S V+ V NLL LF IPQ++Y+++S LS+K +K FLR +P+D QA
Sbjct: 154 KPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQAR 213
Query: 196 AMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHV 255
AM DI++ + W +V + + +YG G++ F+E A + +CI S+ I + E+ +
Sbjct: 214 AMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRL 273
Query: 256 VEVIQN--STAKVIVVFSSGPDLEPLIKEIVRRNITGKIWL-ASEAWASSSLIAMPQYFH 312
+ ++ A+V+V F G + L+ + R + G+ L S+ WA + + Y
Sbjct: 274 LRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEV-IEGYEV 332
Query: 313 VVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDT 372
G I L++ ++ F ++ K+ + N + EFW+ F C L
Sbjct: 333 EANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRL------------ 380
Query: 373 FLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQ 432
G N + F+ +CTG+E S+E Y+ + + N A+Y++AH LQ
Sbjct: 381 -------PGHLLENPN--FKRICTGNE---SLEENYVQDSKMGFVIN---AIYAMAHGLQ 425
Query: 433 DIYTCL-PGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSI 491
+++ L PG G C +K ++ ++L L +F GE+V FDE GD G Y I
Sbjct: 426 NMHHALCPGH----VGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDI 481
Query: 492 INWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTR 551
+N + E + VG ++ + I K SG R V CS CL G
Sbjct: 482 MNLQYT-EANRYDYVHVGTWHEGVLNIDDYKIQMNK---SGVVRSV----CSEPCLKGQI 533
Query: 552 KGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEP 611
K I +GE +CC+ C C + EY D C C +W N + T C + +L W+
Sbjct: 534 KVIRKGEVSCCWICTACKENEYVQ--DEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNI 591
Query: 612 FGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGE 671
I F+ LGI +T FV +F+ +R+TP+VK+++REL Y++L + + I +
Sbjct: 592 ESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAK 651
Query: 672 PQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRK--WWGLNLQFLLVF 729
P +C L++ G+S +C S ++ KTNR+ + RK + Q ++
Sbjct: 652 PTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIAS 711
Query: 730 LCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFF 789
+ +Q+ + V + PP + E +++ C+ +L + L GY LL C +
Sbjct: 712 ILISVQLTLVVTLIIMEPPMPILSYPSIKE-VYLICNTSNLGVVAPL-GYNGLLIMSCTY 769
Query: 790 FAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLL 849
+AFK+R +P NFNEAK+I F+M I+W++F+P Y + K ++ +++ L
Sbjct: 770 YAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTV--AL 827
Query: 850 ACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRS---NVSRKRSSSLGGST 906
C+F K+YII+ KP RN S + R + N+ R++ + G +
Sbjct: 828 GCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNAN 887
Query: 907 GSTPSSSISSKSNSEDP 923
+ S S S + P
Sbjct: 888 SNGKSVSWSEPGGGQVP 904
>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
precursor [Homo sapiens]
Length = 906
Score = 374 bits (961), Expect = e-103
Identities = 263/914 (28%), Positives = 440/914 (48%), Gaps = 70/914 (7%)
Query: 26 AQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINSSP 85
A+ GD+I+G LF +H A+ + E IR + G + ++AM +++IN+ P
Sbjct: 39 ARMDGDVIIGALFSVHHQPPAEKVPERKCGE----IREQY-GIQRVEAMFHTLDKINADP 93
Query: 86 ALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCN-C---SEHIPS---- 137
LLPN+TLG I D+C S ALE ++ F+ + I + + N C + +P
Sbjct: 94 VLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTK 153
Query: 138 --TIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQAT 195
V+G S V+ V NLL LF IPQ++Y+++S LS+K +K FLR +P+D QA
Sbjct: 154 KPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQAR 213
Query: 196 AMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHV 255
AM DI++ + W +V + + +YG G++ F+E A + +CI S+ I + E+ +
Sbjct: 214 AMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRL 273
Query: 256 VEVIQN--STAKVIVVFSSGPDLEPLIKEIVRRNITGKIWL-ASEAWASSSLIAMPQYFH 312
+ ++ A+V+V F G + L+ + R + G+ L S+ WA + + Y
Sbjct: 274 LRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEV-IEGYEV 332
Query: 313 VVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDT 372
G I L++ ++ F ++ K+ + N + EFW+ F C L
Sbjct: 333 EANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRL------------ 380
Query: 373 FLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNVYLAVYSIAHALQ 432
G N + F+ +CTG+E S+E Y+ + + N A+Y++AH LQ
Sbjct: 381 -------PGHLLENPN--FKRICTGNE---SLEENYVQDSKMGFVIN---AIYAMAHGLQ 425
Query: 433 DIYTCL-PGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFDECGDLVGNYSI 491
+++ L PG G C +K ++ ++L L +F GE+V FDE GD G Y I
Sbjct: 426 NMHHALCPGH----VGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDI 481
Query: 492 INWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTR 551
+N + E + VG ++ + I K SG R V CS CL G
Sbjct: 482 MNLQYT-EANRYDYVHVGTWHEGVLNIDDYKIQMNK---SGVVRSV----CSEPCLKGQI 533
Query: 552 KGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEP 611
K I +GE +CC+ C C + EY D C C +W N + T C + +L W+
Sbjct: 534 KVIRKGEVSCCWICTACKENEYVQ--DEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNI 591
Query: 612 FGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGE 671
I F+ LGI +T FV +F+ +R+TP+VK+++REL Y++L + + I +
Sbjct: 592 ESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAK 651
Query: 672 PQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRK--WWGLNLQFLLVF 729
P +C L++ G+S +C S ++ KTNR+ + RK + Q ++
Sbjct: 652 PTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIAS 711
Query: 730 LCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFF 789
+ +Q+ + V + PP + E +++ C+ +L + L GY LL C +
Sbjct: 712 ILISVQLTLVVTLIIMEPPMPILSYPSIKE-VYLICNTSNLGVVAPL-GYNGLLIMSCTY 769
Query: 790 FAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLL 849
+AFK+R +P NFNEAK+I F+M I+W++F+P Y + K ++ +++ L
Sbjct: 770 YAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTV--AL 827
Query: 850 ACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRS---NVSRKRSSSLGGST 906
C+F K+YII+ KP RN S + R + N+ R++ + G +
Sbjct: 828 GCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNAK 887
Query: 907 GSTPSSSISSKSNS 920
P S +S+ S
Sbjct: 888 KRQPEFSPTSQCPS 901
>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
Length = 480
Score = 219 bits (558), Expect = 1e-56
Identities = 140/443 (31%), Positives = 214/443 (48%), Gaps = 56/443 (12%)
Query: 5 SCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIR-- 62
SCCW A H++ PD GD +L GLFP+H G ++ RPE C R
Sbjct: 16 SCCW---AFACHSTESSPDFTLP--GDYLLAGLFPLHSGCL----QVRHRPEVTLCDRSC 66
Query: 63 -YNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSK--ALEATLSFVAQNK 119
+N G+ QAM +EEIN+S ALLPN+TLGY+++D C+ + A LS Q+
Sbjct: 67 SFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHH 126
Query: 120 IDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ 179
I+ + + P+ +AV+G + + A LL F +P +SYA+SS LS K Q
Sbjct: 127 IELQG-----DLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQ 181
Query: 180 FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDF 239
+ SFLRTIPND++Q M +++ F W W+ + + DDYG+ G++ +A + ICI F
Sbjct: 182 YPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAF 241
Query: 240 SELI--SQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASE 297
+++ S +E +Q ++ + + A V+VVFSS + +V N+TGK+W+ASE
Sbjct: 242 KDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASE 301
Query: 298 AWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFN 357
AWA S I +G +G A++ +PG + F EE +
Sbjct: 302 AWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAF-------------------EEAY- 341
Query: 358 CHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 417
+ K P P S + LC + + P + + +
Sbjct: 342 --ARADKKAPRPC-------------HKGSWCSSNQLCRECQAFMAHTMPKLKAFSMSSA 386
Query: 418 YNVYLAVYSIAHALQDIYTCLPG 440
YN Y AVY++AH L + C G
Sbjct: 387 YNAYRAVYAVAHGLHQLLGCASG 409
>gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]
Length = 587
Score = 203 bits (517), Expect = 6e-52
Identities = 123/405 (30%), Positives = 205/405 (50%), Gaps = 13/405 (3%)
Query: 475 EQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFS 534
+ V F++ D + +Y+II W + + ++ +L INE KI W G
Sbjct: 181 DTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPV-----QLNINETKIQWHGKD 235
Query: 535 REVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNEN 594
+VP S CS DCL G ++ ++ G CCFECV C G + +++D C C + W+ E
Sbjct: 236 NQVPKSVCSSDCLEGHQR-VVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEG 294
Query: 595 HTSCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLL 654
+C + + FL+ E L L + L G+F +TP+V++ L +L+
Sbjct: 295 SQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSAGGRLCFLM 354
Query: 655 LFSLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFE--AKIPT 712
L SL S F GEP C LRQ F + F + +SC+ V++ +++++F+ K+PT
Sbjct: 355 LGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPT 414
Query: 713 SFHRKWWGLNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMA 772
+H W + L V + + Q++IC+ WL P R + ++ + C E + +
Sbjct: 415 FYH-AWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLECTETN--S 471
Query: 773 LGFLIG--YTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYG 830
LGF++ Y LL+ F ++ + LPEN+NEAK +TFS+L F+ WI+F + G
Sbjct: 472 LGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDG 531
Query: 831 KFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCS 875
K++ A ++A L++ F K Y+IL +P N+ E + S
Sbjct: 532 KYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQAS 576
Score = 88.6 bits (218), Expect = 3e-17
Identities = 57/166 (34%), Positives = 84/166 (50%), Gaps = 19/166 (11%)
Query: 5 SCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIR-- 62
SCCW A H++ PD GD +L GLFP+H G ++ RPE C R
Sbjct: 16 SCCW---AFACHSTESSPDFTLP--GDYLLAGLFPLHSGCL----QVRHRPEVTLCDRSC 66
Query: 63 -YNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSK--ALEATLSFVAQNK 119
+N G+ QAM +EEIN+S ALLPN+TLGY+++D C+ + A LS Q+
Sbjct: 67 SFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHH 126
Query: 120 IDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQV 165
I+ + + P+ +AV+G + + A LL F +P +
Sbjct: 127 IELQG-----DLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPML 167
>gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo
sapiens]
Length = 254
Score = 124 bits (310), Expect = 6e-28
Identities = 76/247 (30%), Positives = 120/247 (48%), Gaps = 17/247 (6%)
Query: 665 SLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQ 724
+ FI +P C LR+ G +F +C S +L KTNR+ +F + ++ Q
Sbjct: 2 TFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQ 61
Query: 725 FLLVFLCTFMQIVICVIWLYTAPPSSYRNQELED-EIIFITCHEGSLMALGFLIGYTCLL 783
+ Q++I V WL P + + E E++ + C+ LG L Y LL
Sbjct: 62 VAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSL-AYNVLL 120
Query: 784 AAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILA 843
A+C +AFK+RK PENFNEAKFI F+M I+W++F+P + T + + +
Sbjct: 121 IALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSV 180
Query: 844 ASFG--LLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSS 901
+ G +L C+F K++IILF+P +N + T R + + + SSS
Sbjct: 181 SLSGSVVLGCLFAPKLHIILFQPQKNVVSH-------------RAPTSRFGSAAARASSS 227
Query: 902 LGGSTGS 908
LG +GS
Sbjct: 228 LGQGSGS 234
>gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens]
Length = 324
Score = 88.6 bits (218), Expect = 3e-17
Identities = 57/166 (34%), Positives = 84/166 (50%), Gaps = 19/166 (11%)
Query: 5 SCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIR-- 62
SCCW A H++ PD GD +L GLFP+H G ++ RPE C R
Sbjct: 16 SCCW---AFACHSTESSPDFTLP--GDYLLAGLFPLHSGCL----QVRHRPEVTLCDRSC 66
Query: 63 -YNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSK--ALEATLSFVAQNK 119
+N G+ QAM +EEIN+S ALLPN+TLGY+++D C+ + A LS Q+
Sbjct: 67 SFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHH 126
Query: 120 IDSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQV 165
I+ + + P+ +AV+G + + A LL F +P +
Sbjct: 127 IELQG-----DLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPML 167
Score = 57.8 bits (138), Expect = 6e-08
Identities = 33/103 (32%), Positives = 53/103 (51%), Gaps = 6/103 (5%)
Query: 475 EQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFS 534
+ V F++ D + +Y+II W + + ++ +L INE KI W G
Sbjct: 181 DTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPV-----QLNINETKIQWHGKD 235
Query: 535 REVPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDET 577
+VP S CS DCL G ++ ++ G CCFECV C G + +++
Sbjct: 236 NQVPKSVCSSDCLEGHQR-VVTGFHHCCFECVPCGAGTFLNKS 277
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/158 (24%), Positives = 76/158 (48%), Gaps = 6/158 (3%)
Query: 151 TAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVG 210
T V+ G + IP + + + S+K+ SFLRT+P HQ++ +++ + WN +
Sbjct: 105 TPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHII 164
Query: 211 TIAADDDYGRPGIEKFREEAEERDICIDFSELISQYS-DEEEIQHVVEVIQNSTAKVIVV 269
+ +DD GR ++ EER+ +E + Q+ + + ++ + A+VI++
Sbjct: 165 LLVSDDHEGRAAQKRLETLLEERE---SKAEKVLQFDPGTKNVTALLMEAKELEARVIIL 221
Query: 270 FSSGPDLEPLIKEIVRRNITGK--IWLASEAWASSSLI 305
+S D + + N+TG +WL E S + +
Sbjct: 222 SASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNAL 259
Score = 30.8 bits (68), Expect = 7.2
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 12/71 (16%)
Query: 469 FTNNMGEQVTFDECGDL-VGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK 527
+ + + +V F+E GD NYSI+N ++ +V +VG YN G + N+ K
Sbjct: 330 YADGVTGRVEFNEDGDRKFANYSIMNL----QNRKLV--QVGIYN-----GTHVIPNDRK 378
Query: 528 ILWSGFSREVP 538
I+W G E P
Sbjct: 379 IIWPGGETEKP 389
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/158 (24%), Positives = 76/158 (48%), Gaps = 6/158 (3%)
Query: 151 TAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVG 210
T V+ G + IP + + + S+K+ SFLRT+P HQ++ +++ + WN +
Sbjct: 105 TPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHII 164
Query: 211 TIAADDDYGRPGIEKFREEAEERDICIDFSELISQYS-DEEEIQHVVEVIQNSTAKVIVV 269
+ +DD GR ++ EER+ +E + Q+ + + ++ + A+VI++
Sbjct: 165 LLVSDDHEGRAAQKRLETLLEERE---SKAEKVLQFDPGTKNVTALLMEAKELEARVIIL 221
Query: 270 FSSGPDLEPLIKEIVRRNITGK--IWLASEAWASSSLI 305
+S D + + N+TG +WL E S + +
Sbjct: 222 SASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNAL 259
Score = 30.8 bits (68), Expect = 7.2
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 12/71 (16%)
Query: 469 FTNNMGEQVTFDECGDL-VGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK 527
+ + + +V F+E GD NYSI+N ++ +V +VG YN G + N+ K
Sbjct: 330 YADGVTGRVEFNEDGDRKFANYSIMNL----QNRKLV--QVGIYN-----GTHVIPNDRK 378
Query: 528 ILWSGFSREVP 538
I+W G E P
Sbjct: 379 IIWPGGETEKP 389
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/158 (24%), Positives = 76/158 (48%), Gaps = 6/158 (3%)
Query: 151 TAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVG 210
T V+ G + IP + + + S+K+ SFLRT+P HQ++ +++ + WN +
Sbjct: 105 TPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHII 164
Query: 211 TIAADDDYGRPGIEKFREEAEERDICIDFSELISQYS-DEEEIQHVVEVIQNSTAKVIVV 269
+ +DD GR ++ EER+ +E + Q+ + + ++ + A+VI++
Sbjct: 165 LLVSDDHEGRAAQKRLETLLEERE---SKAEKVLQFDPGTKNVTALLMEAKELEARVIIL 221
Query: 270 FSSGPDLEPLIKEIVRRNITGK--IWLASEAWASSSLI 305
+S D + + N+TG +WL E S + +
Sbjct: 222 SASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNAL 259
Score = 30.8 bits (68), Expect = 7.2
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 12/71 (16%)
Query: 469 FTNNMGEQVTFDECGDL-VGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEK 527
+ + + +V F+E GD NYSI+N ++ +V +VG YN G + N+ K
Sbjct: 330 YADGVTGRVEFNEDGDRKFANYSIMNL----QNRKLV--QVGIYN-----GTHVIPNDRK 378
Query: 528 ILWSGFSREVP 538
I+W G E P
Sbjct: 379 IIWPGGETEKP 389
>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
Length = 941
Score = 58.2 bits (139), Expect = 4e-08
Identities = 38/145 (26%), Positives = 75/145 (51%), Gaps = 18/145 (12%)
Query: 71 LQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCN 130
L A+ AIE+I + L P L R++DT +K L+A F +
Sbjct: 78 LPAVELAIEQIRNESLLRPYF-LDLRLYDTECDNAKGLKA-----------------FYD 119
Query: 131 CSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPND 190
++ P+ + V G V++ +A L + + Q+S+A+++ +L++K ++ F RT+P+D
Sbjct: 120 AIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSD 179
Query: 191 EHQATAMADIIEYFRWNWVGTIAAD 215
A+ ++++++W VGT+ D
Sbjct: 180 NAVNPAILKLLKHYQWKRVGTLTQD 204
>gi|8923705 G protein-coupled receptor, family C, group 5, member D
[Homo sapiens]
Length = 345
Score = 51.2 bits (121), Expect = 5e-06
Identities = 54/219 (24%), Positives = 96/219 (43%), Gaps = 25/219 (11%)
Query: 611 PFGIALTLFAVLGIFLTAFVLGVFI----KFRNTPIVKATNRELSYLLLFSLLCCFSSSL 666
P+GI L A+LGI +T +L F+ K ++ +L +LL S+L F +
Sbjct: 21 PWGIILESLAILGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLL--SVLGLFGLAF 78
Query: 667 FFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFL 726
FI E T +R FG+ F LC SC+L + ++ + + S W +
Sbjct: 79 AFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLVKLVRGCVSFS----WTTI---LC 131
Query: 727 LVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSL-MALGFLIGYTCLLAA 785
+ C+ +QI+I + Y + ++F+ L + L+ Y L A
Sbjct: 132 IAIGCSLLQIIIA---------TEYVTLIMTRGMMFVNMTPCQLNVDFVVLLVYVLFLMA 182
Query: 786 ICFFFAFKSRKLP-ENFNE-AKFITFSMLIFFIVWISFI 822
+ FF + + P EN+ + + I ++L I+W+ +I
Sbjct: 183 LTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWI 221
>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
precursor [Homo sapiens]
Length = 899
Score = 50.4 bits (119), Expect = 9e-06
Identities = 39/149 (26%), Positives = 67/149 (44%), Gaps = 7/149 (4%)
Query: 147 SGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRW 206
S VST VA ++ + +SY SSS LSN+ +F +F RT P+ + E + W
Sbjct: 185 SSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGW 244
Query: 207 NWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKV 266
+ TI + ++ E +E I I F + S +SD V+ ++ A++
Sbjct: 245 KKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQ--SFFSDPAV---PVKNLKRQDARI 299
Query: 267 IVVFSSGPDLEPLIKEIVRRNITGK--IW 293
IV + + E+ + + GK +W
Sbjct: 300 IVGLFYETEARKVFCEVYKERLFGKKYVW 328
>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
precursor [Homo sapiens]
Length = 844
Score = 50.4 bits (119), Expect = 9e-06
Identities = 39/149 (26%), Positives = 67/149 (44%), Gaps = 7/149 (4%)
Query: 147 SGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRW 206
S VST VA ++ + +SY SSS LSN+ +F +F RT P+ + E + W
Sbjct: 130 SSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGW 189
Query: 207 NWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKV 266
+ TI + ++ E +E I I F + S +SD V+ ++ A++
Sbjct: 190 KKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQ--SFFSDPAV---PVKNLKRQDARI 244
Query: 267 IVVFSSGPDLEPLIKEIVRRNITGK--IW 293
IV + + E+ + + GK +W
Sbjct: 245 IVGLFYETEARKVFCEVYKERLFGKKYVW 273
>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
precursor [Homo sapiens]
Length = 961
Score = 50.4 bits (119), Expect = 9e-06
Identities = 39/149 (26%), Positives = 67/149 (44%), Gaps = 7/149 (4%)
Query: 147 SGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRW 206
S VST VA ++ + +SY SSS LSN+ +F +F RT P+ + E + W
Sbjct: 247 SSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGW 306
Query: 207 NWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQHVVEVIQNSTAKV 266
+ TI + ++ E +E I I F + S +SD V+ ++ A++
Sbjct: 307 KKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQ--SFFSDPAV---PVKNLKRQDARI 361
Query: 267 IVVFSSGPDLEPLIKEIVRRNITGK--IW 293
IV + + E+ + + GK +W
Sbjct: 362 IVGLFYETEARKVFCEVYKERLFGKKYVW 390
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 48.1 bits (113), Expect = 4e-05
Identities = 61/257 (23%), Positives = 101/257 (39%), Gaps = 55/257 (21%)
Query: 73 AMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNLDEFCNCS 132
A FA+ IN + LLPN TL Y DT + + SF A K C
Sbjct: 56 AFRFAVNTINRNRTLLPNTTLTY---DT-----QKINLYDSFEASKKA----------CD 97
Query: 133 EHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEH 192
+ A+ G + S + AV ++ +P + ++ NK+ F ++ P+
Sbjct: 98 QLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSS 155
Query: 193 QATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEI 252
+ A+ D++++F+W V T+ DD G I ELI S
Sbjct: 156 LSRAILDLVQFFKWKTV-TVVYDDSTG----------------LIRLQELIKAPSR---- 194
Query: 253 QHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWASS------SLIA 306
N K+ + + D +PL+KE+ R I+ S A+ ++
Sbjct: 195 -------YNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGM 247
Query: 307 MPQYFHVVGGTIG-FAL 322
M +Y+H + T+ FAL
Sbjct: 248 MTEYYHYIFTTLDLFAL 264
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,906,135
Number of Sequences: 37866
Number of extensions: 1953365
Number of successful extensions: 11135
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 124
Number of HSP's successfully gapped in prelim test: 110
Number of HSP's that attempted gapping in prelim test: 7951
Number of HSP's gapped (non-prelim): 1675
length of query: 1078
length of database: 18,247,518
effective HSP length: 113
effective length of query: 965
effective length of database: 13,968,660
effective search space: 13479756900
effective search space used: 13479756900
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.