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Search of human proteins with 36031016
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
(898 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 1733 0.0
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 130 5e-30
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 130 7e-30
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 129 1e-29
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 129 2e-29
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 126 8e-29
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 125 2e-28
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 124 5e-28
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 124 5e-28
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 124 5e-28
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 124 5e-28
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 121 3e-27
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 120 6e-27
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 120 7e-27
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 119 1e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 118 2e-26
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 118 2e-26
gi|156104908 myosin heavy chain 6 [Homo sapiens] 118 2e-26
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 117 5e-26
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 117 6e-26
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 115 2e-25
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 114 3e-25
gi|58530840 desmoplakin isoform I [Homo sapiens] 114 3e-25
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 114 3e-25
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 114 3e-25
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 114 5e-25
gi|55770834 centromere protein F [Homo sapiens] 112 1e-24
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 112 2e-24
gi|118498356 kinectin 1 isoform a [Homo sapiens] 110 8e-24
gi|33620775 kinectin 1 isoform a [Homo sapiens] 110 8e-24
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 1733 bits (4488), Expect = 0.0
Identities = 898/898 (100%), Positives = 898/898 (100%)
Query: 1 MSETDHIASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHN 60
MSETDHIASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHN
Sbjct: 1 MSETDHIASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHN 60
Query: 61 NRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILV 120
NRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILV
Sbjct: 61 NRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILV 120
Query: 121 ELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRV 180
ELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRV
Sbjct: 121 ELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRV 180
Query: 181 PNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKR 240
PNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKR
Sbjct: 181 PNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKR 240
Query: 241 TETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKK 300
TETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKK
Sbjct: 241 TETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKK 300
Query: 301 CEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRL 360
CEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRL
Sbjct: 301 CEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRL 360
Query: 361 HQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKL 420
HQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKL
Sbjct: 361 HQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKL 420
Query: 421 TQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAK 480
TQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAK
Sbjct: 421 TQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAK 480
Query: 481 IKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKV 540
IKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKV
Sbjct: 481 IKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKV 540
Query: 541 KTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNA 600
KTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNA
Sbjct: 541 KTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNA 600
Query: 601 QLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELA 660
QLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELA
Sbjct: 601 QLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELA 660
Query: 661 CRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSM 720
CRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSM
Sbjct: 661 CRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSM 720
Query: 721 GSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIE 780
GSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIE
Sbjct: 721 GSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIE 780
Query: 781 FMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPA 840
FMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPA
Sbjct: 781 FMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPA 840
Query: 841 DNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT 898
DNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT
Sbjct: 841 DNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT 898
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 130 bits (327), Expect = 5e-30
Identities = 176/777 (22%), Positives = 338/777 (43%), Gaps = 119/777 (15%)
Query: 152 KIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQ----QEH 207
K V E + + L EF + RV K ++ ++L K + + L+ +
Sbjct: 318 KAVRVDKLESEVSRYKERLHDIEFYKARVEE--LKEDNQVLLETKTMLEDQLEGTRARSD 375
Query: 208 IIKKLIKENKKHQELFVDICSEKDNLREELKKRTE-------TEKQHMNTIKQLESRIEE 260
+ +L KEN + + D+ E+D R+++++ E +KQ M+ L +E+
Sbjct: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435
Query: 261 LNK--EVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEAR---QEKEAMVMKY 315
+++ E+ + + + +V + + L EM + K EE R E K
Sbjct: 436 ISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN--QSLTKTVEELRTTVDSVEGNASKI 493
Query: 316 VRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLI 375
++ EKE+ L K+ E LE ++ + L+ N K L +EK +L + ET + R I
Sbjct: 494 LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 376 REIDKLKEDINSHVIKVKWAQNKLKAE---MDSHKETK---DKLKETTTKLTQAKEEADQ 429
+ +++ E +N V ++ ++++ AE D KE K + +KET++KL++ + E Q
Sbjct: 554 KILEQENEHLNQTVSSLR-QRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 430 IRKNCQDMIKTYQESEEI--------KSNELDAK----LRVTKGELEKQMQEKSDQLEMH 477
I+K + + + +EE+ K NEL K L++T ++E QE S
Sbjct: 613 IKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENS------ 666
Query: 478 HAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLL 537
ELE R K+ +D + L +++ LE E + ++E E++ +
Sbjct: 667 -----ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE-----------NLELRRNV 710
Query: 538 DKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTS 597
+ +K A QLQ +E+E+ KE+++ L ++ S K+ TERL
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLEL-------LKASFKK-------TERLEV 756
Query: 598 KNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQA 657
L E+ LQ + + QL+S+ + ++ N L+ L+E ++ + ++ L+
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEK 815
Query: 658 ELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEV 717
E + E L ++L+ E +R + + IKD T + + V+ G+ +KE
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKE--NKRLRQQAEIKDTTLE-------ENNVKIGNLEKEN 866
Query: 718 SSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNE 777
++ R ++ + +D I+ +V L++ +
Sbjct: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATID----------IKTLVTLREDLVSEKL 916
Query: 778 KIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTS 837
K + M + +++L E+ +K + + +L +E T S R ++ S S
Sbjct: 917 KTQQMNNDLEKLTHEL-EKIGLNKERLLHDEQSTDDS------------RYKLLESKLES 963
Query: 838 HPADNGLTLELSLEINRK----LQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHE 890
TL+ SLEI + L+A LE++ N L++ L+T+ E L + Q E
Sbjct: 964 -------TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1013
Score = 102 bits (255), Expect = 1e-21
Identities = 148/730 (20%), Positives = 303/730 (41%), Gaps = 141/730 (19%)
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
+K+LI E +H E +++ E+D L H ++ Q + + S
Sbjct: 197 LKRLIDERDEHSETIIELSEERDGLHF---------LPHASSSAQSPCGSPGMKRT--ES 245
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKE 328
R L + AK +++L +E+ ++ EQ + +QE E M ++ R ++E+++L +
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLL----DCKQELEQMEIELKRLQQENMNLLSD 301
Query: 329 KETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSH 388
+ + RD L + ++ +L E R + E R +++LKED N
Sbjct: 302 ARSA-RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR----VEELKED-NQV 355
Query: 389 VIKVKWAQNKLKAEMDSHKETKDKLKETT-------TKLTQAKEEADQIRKNCQDMIKTY 441
+++ K L+ +++ + DKL E KL + E D RK +++++
Sbjct: 356 LLETK---TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
Query: 442 QESEEIKSNELDAKLRV--------TKGELEKQMQEK--SDQLEMHHAKIKELEDLKRTF 491
E + +D L + EL + Q+ + E+ +++ +LE ++
Sbjct: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 492 KEGMDELRTLRTKVKCLEDERLRTEDE---LSKYKEIIN----RQKAEIQNLL----DKV 540
+ ++ELRT V+ + L+ E E LSK EI+ ++K +QN D +
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
Query: 541 KTADQLQEQLQ----RGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLT 596
K QL++ ++ +++I+ L++E E LN ++ L++ + S + + +
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEAR------VKDIE 586
Query: 597 SKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLES------RLLKEEELRKE 650
+N L S+ K+ + Q++ + E K+ E L KE EL ++
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQK 646
Query: 651 EVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVES 710
++ L+ + C + E AL + EL+ E + +K S K+LT QL+ ++ Q++
Sbjct: 647 KITNLK--ITCEKIE--ALEQENSELEREN-RKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 711 GSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQK 770
+ + + R V K
Sbjct: 702 ENLE-----------------------------------------------LRRNVESLK 714
Query: 771 AHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGI 830
+ K +++ ++ E+++K +++++ + E +S + D L +
Sbjct: 715 CASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK---- 770
Query: 831 MASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTL---GTEIERLIKH 887
TLE S + ++L++ L+D ++N TL++NL+ L +E+L K
Sbjct: 771 --------------TLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 888 QHELEQRTKK 897
LEQ T +
Sbjct: 817 NKSLEQETSQ 826
Score = 98.2 bits (243), Expect = 3e-20
Identities = 152/723 (21%), Positives = 311/723 (43%), Gaps = 91/723 (12%)
Query: 34 ESSKLENESKLLSLNTDKTLC------QPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGS 87
E+S+L+ E+ L N + C Q N +E+++ + + K
Sbjct: 695 ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERL 754
Query: 88 ENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTK 147
E S Q + + K + +N+ K+ Q+ EL+ +K E + +
Sbjct: 755 EVSYQGLDIENQRLQKTLENSNK---KIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
Query: 148 KFISKIKSVSASEDLLEEI-------------ESELLSTEFAEHRVPNGMNKGEHAL--- 191
+ + KS+ LE+ ++E+ T E+ V G + E+
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 192 ---VLFEKCVQDKYLQQEH--IIKKLIKENKKHQELFVDICSEK---DNLREELKKRT-E 242
+ E CV+ K L++E+ ++K+ + K L D+ SEK + +L+K T E
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
Query: 243 TEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQ---RMEQANK 299
EK +N + L + K +L + T K +++ +++A R+E++
Sbjct: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESKL---ESTLKKSLEIKEEKIAALEARLEESTN 988
Query: 300 KCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGR 359
++ RQE +K V+ E+L R+++E ++ ++ + NK ++ SQE R
Sbjct: 989 YNQQLRQE-----LKTVKKNYEALKQRQDEE----RMVQSSPPISGEDNKWERESQETTR 1039
Query: 360 LHQLYETKEG--ETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKE-- 415
+L + K+ E R + K+ + + + +++ N L+A++ + + L+E
Sbjct: 1040 --ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1097
Query: 416 TTTKLTQAKEEADQIRKNCQDMIKTYQESEE-IKSNELDAKLRVTKGELEKQMQEKSDQL 474
TT + AK + + N Q Q ++ I+ + L+ E E ++E+ D
Sbjct: 1098 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE-------NENESVIKEREDLK 1150
Query: 475 EMHHAKIKELEDLKRTFKEGMDELR-------TLRTKVKCLEDERLRTEDELSKYKEIIN 527
++ + IK+ E L+ + E TL++ K LE E ED +Y +++
Sbjct: 1151 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED---RYNQLL- 1206
Query: 528 RQKAEIQNLLDKVKTADQLQEQLQRGKQEI-----ENLKEEVESLNSLINDLQKDIEGSR 582
+QK ++++L +K+ +Q + L+ E + L E + LN + L K+ E +
Sbjct: 1207 KQKGQLEDL-EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1265
Query: 583 KRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLL 642
L + +L++E + L+ Q+ ++ + ++L +QCE + Q NLE
Sbjct: 1266 TDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE---- 1321
Query: 643 KEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQAR 702
+E +++QTL + + L Q E KD ++R++ + +L +Q ++
Sbjct: 1322 EENRHLLDQIQTL-------MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE 1374
Query: 703 RKL 705
K+
Sbjct: 1375 EKI 1377
Score = 96.7 bits (239), Expect = 9e-20
Identities = 139/582 (23%), Positives = 266/582 (45%), Gaps = 72/582 (12%)
Query: 379 DKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMI 438
D +EDI + + +L E D H ET +L E L + + C
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 439 KTYQESEEIKSNEL-DAKLRVTKGELEKQMQEKSDQLEMHHAKIKELE-DLKRTFKEGMD 496
ES + S EL DAK ++ + L ++++EK++QL +++++E +LKR +E M+
Sbjct: 240 MKRTESRQHLSVELADAKAKIRR--LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMN 297
Query: 497 EL------RTLRTKVKCLEDERLRT---EDELSKYKE---IINRQKAEIQNLLDK----V 540
L R R ++ L ++ +R E E+S+YKE I KA ++ L + +
Sbjct: 298 LLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 541 KTADQLQEQLQRGK---QEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTS 597
+T L++QL+ + ++ L++E L + ++D++ + + RK+ EL+ E +T
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM--EENMTL 415
Query: 598 KNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMK---QTNINLESRLLK----------- 643
+ AQ QS SL ++ S + S+ Q + N SRLLK
Sbjct: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
Query: 644 EEELRK--EEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQA 701
EELR + V+ +++ + E + LS +VE L++E+V Q ++ + ++L+K L +
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV-QEKQSLQNCQNLSKDLMKE 534
Query: 702 RRKLDQV-----------------ESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENT 744
+ +L++ E+ ++ VSS+ RS ++A + +D EN
Sbjct: 535 KAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS----QISAEARVKDIEKENK 590
Query: 745 GSSVAV-DNFPQVDKAMLIERIVRLQKAHAR-KNEKIEFMEDHIKQLVEEIR-KKTKIIQ 801
++ + ++ K +R ++ + H + K E+ E +E+ + L +E + KI
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650
Query: 802 SYILREESGTLSSEASDFNKVHLSRRGGI-----MASLYTSHPADNGLTLELSLEINRKL 856
I E+ L E S+ + + + + + S +N E +LE+ R +
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 857 QAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT 898
++ L+ +K L+ + L +E E+L K L+ KKT
Sbjct: 711 ES-LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
Score = 39.3 bits (90), Expect = 0.017
Identities = 42/169 (24%), Positives = 73/169 (43%), Gaps = 29/169 (17%)
Query: 200 DKYLQQEHIIKKLIKENKKHQELFVD---ICSEKDNLRE---ELKKRTETEKQHMNTIKQ 253
+K L+ E +K++ ENK H+ + + +C E D L +L K TE + +K
Sbjct: 1216 EKMLKVEQ--EKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273
Query: 254 L--ESRIEELNKEVKASR--DQLIAQDVTAKNAVQQ--LHKEMAQRMEQANKKCEEARQE 307
L S++E+ E + S+ +Q D+T+ Q L ++ +E+ N+ + Q
Sbjct: 1274 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1333
Query: 308 KEAMVMKYVRGEKESLDL---------------RKEKETLEKKLRDANK 341
+ ES DL R++KE LE+K+ D K
Sbjct: 1334 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1382
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 130 bits (326), Expect = 7e-30
Identities = 134/668 (20%), Positives = 309/668 (46%), Gaps = 77/668 (11%)
Query: 82 KTDTGSENSEQIANFPSGNFAK-------HISKTNETEQKVTQILVELRSSTFPESANEK 134
+TD S N+E I+ GN K +S+ E++ +++ +L +
Sbjct: 1230 ETDDLSSNAEAISK-AKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAG 1288
Query: 135 TYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLF 194
YS + D +S+ K S + +EE++ +L A++ + + + H L
Sbjct: 1289 EYSRQLDEKDALVSQLSRSKQASTQQ--IEELKHQLEEETKAKNALAHALQSSRHDCDLL 1346
Query: 195 EKCVQDKYLQQEHIIKKLIKENK-------KHQELFVDICSEKDNLREELKKRTETEKQH 247
+ +++ + + + L K N K++ + E + +++L +R + ++H
Sbjct: 1347 REQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEH 1406
Query: 248 MNTI-----------KQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQ 296
+ + ++L++ +E+L +V+ S A D +N + L E Q+ E+
Sbjct: 1407 VEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVL-SEWKQKYEE 1465
Query: 297 ANKKCEEARQEKEAM---VMKYVRGEKESLD----LRKEKETLEKKLRDANKELEKNTNK 349
+ E +++E ++ + K +ESLD LR+E + L++++ D +++ + +
Sbjct: 1466 TQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQ 1525
Query: 350 IKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKET 409
I +L + K ++ Q ++ E + E + E +++++ N++K+E+D
Sbjct: 1526 IHELEKIKKQVEQ----EKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR---- 1577
Query: 410 KDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQE 469
K+ + EE DQ+++N +++T Q + + + + LRV K ++E + E
Sbjct: 1578 ---------KIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKK-KMEGDLNE 1627
Query: 470 KSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQ 529
+++++HA E L R ++ L+ + + D+ LR +++L + I+ R+
Sbjct: 1628 M--EIQLNHANRLAAESL-RNYRNTQGILKETQLHL----DDALRGQEDLKEQLAIVERR 1680
Query: 530 KAEIQNLLDKV-KTADQLQEQLQRGKQEIENLKEEVESLN----SLIND---LQKDIEGS 581
+Q ++++ T +Q + + +QE+ + E V+ L+ SLIN L+ D+
Sbjct: 1681 ANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQL 1740
Query: 582 RKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRL 641
+ E++ + K + +++ + + K + + L+ + ++QT +L+ RL
Sbjct: 1741 QSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1800
Query: 642 LKEEELR----KEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQ 697
+ E+L K+++Q L+A + + EV+ ++ E V RKH +K+LT Q
Sbjct: 1801 DEAEQLALKGGKKQIQKLEARVRELEGEVE----NEQKRNAEAVKGLRKHERRVKELTYQ 1856
Query: 698 LQQARRKL 705
++ R+ +
Sbjct: 1857 TEEDRKNV 1864
Score = 117 bits (294), Expect = 4e-26
Identities = 161/737 (21%), Positives = 320/737 (43%), Gaps = 88/737 (11%)
Query: 209 IKKLIKENKKHQELFV---DICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEV 265
IK L+K + +E+ + KD L + KR E E++ + +K+ +L +V
Sbjct: 839 IKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKN----DLQLQV 894
Query: 266 KASRDQLIAQDVTAKNAVQQLHKEMAQ---RMEQANKKCEEARQEKEAMVMKYVRGEKES 322
++ D L A+ +QL K Q ++++ ++ EE + + K + E E
Sbjct: 895 QSEADSL----ADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDEC 950
Query: 323 LDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLK 382
+L+K+ + LE L KE NK+K L++E L + E L +
Sbjct: 951 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTL 1010
Query: 383 EDINSHVIKVK---WAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIK 439
+D+ + KV A+ KL+ ++D + + ++ K+ L +AK + + K Q+
Sbjct: 1011 DDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070
Query: 440 TYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELR 499
+ ++ +LD KL + E+ + + D+ + K++++L+ +E +E+
Sbjct: 1071 DMENDKQ----QLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIE 1126
Query: 500 TLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQ-EIE 558
R R + E K + ++R+ EI L++ A Q +L + ++ E +
Sbjct: 1127 AERA-------SRAKAE----KQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQ 1175
Query: 559 NLKEEVESL----NSLINDLQKDIEGSRKRESE----LLLFTERLTSKNAQLQSESNSLQ 610
L+ ++E +++ L+K S E L ++L + ++L+ E++ L
Sbjct: 1176 KLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLS 1235
Query: 611 SQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALS 670
S + +S ++ L+ C ++ + S L +EE ++ + L A+ A QTE S
Sbjct: 1236 SNAEAISKAKGNLEKMCRSLE----DQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYS 1291
Query: 671 TQVEELKDELVTQ--RRKHASS--IKDLTKQLQQARRKLD----QVESGSYDKEVSSMGS 722
Q++E KD LV+Q R K AS+ I++L QL++ + + ++S +D ++
Sbjct: 1292 RQLDE-KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQY 1350
Query: 723 RSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFM 782
G + + + E V + + I+R L++A + ++++
Sbjct: 1351 EEEQEGKAELQRALSKANSE-------VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA 1403
Query: 783 EDHIKQLVEEIR--KKTK-----IIQSYILREESGTLSSEASD-----FNKV---HLSRR 827
E+H++ + + +KTK ++ +L E + A D F+KV +
Sbjct: 1404 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKY 1463
Query: 828 GGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLI-- 885
A L S L+ EL K++ V E++L + TL+ + L EI L
Sbjct: 1464 EETQAELEASQKESRSLSTELF-----KVKNVYEESLDQLETLRRENKNLQQEISDLTEQ 1518
Query: 886 -----KHQHELEQRTKK 897
K HELE+ K+
Sbjct: 1519 IAEGGKQIHELEKIKKQ 1535
Score = 96.7 bits (239), Expect = 9e-20
Identities = 149/756 (19%), Positives = 323/756 (42%), Gaps = 78/756 (10%)
Query: 163 LEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQEL 222
L+ + + E + ++ + K E + ++D+ + + KK+ + + +EL
Sbjct: 1062 LKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEEL 1121
Query: 223 FVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNA 282
+I +E+ R + EKQ + ++LE E L + A+ Q+
Sbjct: 1122 GEEIEAER-------ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQV---------- 1164
Query: 283 VQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESL--------DLRKEKETLEK 334
+L+K+ ++ + EEA + EAMV + +S+ +L++ K+ LEK
Sbjct: 1165 --ELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEK 1222
Query: 335 KLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKW 394
+ + E + ++ + +S+ KG L ++ + E + + L K KE+ +I
Sbjct: 1223 EKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSEL-----KTKEEEQQRLINDLT 1277
Query: 395 AQN-KLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELD 453
AQ +L+ E + D+ ++L+++K+ + Q + +K E E N L
Sbjct: 1278 AQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEE----LKHQLEEETKAKNALA 1333
Query: 454 AKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERL 513
L+ ++ + + ++ ++ E +L+R + E+ RTK E + +
Sbjct: 1334 HALQSSRHDCDLLREQYEEEQE-------GKAELQRALSKANSEVAQWRTK---YETDAI 1383
Query: 514 RTEDELSKYKEIINRQKAEIQNLLDKVKT-ADQLQEQLQRGKQEIENLKEEVESLNSLIN 572
+ +EL + K+ + ++ E + ++ V L++ QR + E+E+L +VE N+
Sbjct: 1384 QRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACA 1443
Query: 573 DLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQ 632
L K K SE E ++ Q ES SL ++ KV + Q E +++
Sbjct: 1444 ALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRR 1503
Query: 633 TNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIK 692
N NL+ + ++ AE + E++ + QVE+ K E+ + +S++
Sbjct: 1504 ENKNLQQEI--------SDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE 1555
Query: 693 DLTKQLQQARRKLDQVES------GSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGS 746
++ + + +L+QV+S D+E+ + + + + + S D +
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQL--KRNHTRVVETMQSTLDAEIRSRND 1613
Query: 747 SVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILR 806
++ V + D L E ++L A+ E + + + I K+T++ LR
Sbjct: 1614 ALRVKKKMEGD---LNEMEIQLNHANRLAAESLRNYRN-----TQGILKETQLHLDDALR 1665
Query: 807 EESGTLSSEASDFNKVHL--SRRGGIMASLYTSHPADNGLTLELSLEINRKLQAV-LEDT 863
+ A + +L + + A+L + + EL L+ + ++Q + ++T
Sbjct: 1666 GQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQEL-LDASERVQLLHTQNT 1724
Query: 864 LLKNI--TLKENLQTLGTEIERLIKHQHELEQRTKK 897
L N L+ ++ L +E+E +I+ E++ KK
Sbjct: 1725 SLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKK 1760
Score = 63.5 bits (153), Expect = 8e-10
Identities = 82/412 (19%), Positives = 174/412 (42%), Gaps = 59/412 (14%)
Query: 229 EKDNLREELKKRTETEKQHMNTIKQLES---RIEELNKEVKASRDQLIAQDVTAKNAVQQ 285
E NL++E+ TE + I +LE ++E+ E++A+ ++ A + + +
Sbjct: 1504 ENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILR 1563
Query: 286 LHKEMAQRMEQANKKCEEARQEKEAMVMKYVR---GEKESLDL----RKEKETLEKKLRD 338
+ E+ Q + ++K E +E + + + R + +LD R + ++KK+
Sbjct: 1564 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEG 1623
Query: 339 ANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNK 398
E+E N +L+ E R ++ + ET + + + +ED+ + V+ N
Sbjct: 1624 DLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANL 1683
Query: 399 LKAEMDS-----------------------------HKE------TKDKLKETTTKLTQA 423
L+AE++ H + TK KL+ ++L
Sbjct: 1684 LQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSE 1743
Query: 424 KEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKE 483
EE Q +N ++ K + + EL K + T LE+ + ++ ++ E
Sbjct: 1744 VEEVIQESRNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNLEQTVKDLQHRLDE 1802
Query: 484 LEDLKRTFKEGMDELRTLRTKVKCLE----DERLRTEDELS-------KYKEIINRQKAE 532
E L K G +++ L +V+ LE +E+ R + + + KE+ + + +
Sbjct: 1803 AEQL--ALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEED 1860
Query: 533 IQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKR 584
+N+L D+LQ +++ K++ E +E+ + S LQ ++E + +R
Sbjct: 1861 RKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEER 1912
Score = 57.8 bits (138), Expect = 5e-08
Identities = 69/432 (15%), Positives = 189/432 (43%), Gaps = 31/432 (7%)
Query: 143 TDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKY 202
+D T++ K + E + +++E E + A + E ++ + +
Sbjct: 1513 SDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQV- 1571
Query: 203 LQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELN 262
+ + +K+ +++++ +L + + ++ L + + K++E + E+
Sbjct: 1572 --KSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEME 1629
Query: 263 KEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKES 322
++ + ++L A+ + Q + KE ++ A + E+ +++ + + + E
Sbjct: 1630 IQLNHA-NRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEI 1688
Query: 323 LDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLK 382
+L E E+ + A +EL + +++ L + L TK+ +L ++ +L+
Sbjct: 1689 EELWATLEQTERSRKIAEQELLDASERVQLLHTQNT---SLINTKK----KLENDVSQLQ 1741
Query: 383 EDINSHVIKVKWAQNKLKAEMDSHKETKDKLK---ETTTKLTQAKEEADQIRKNCQDMIK 439
++ + + + A+ K K + ++LK +T+ L + K+ +Q K+ Q +
Sbjct: 1742 SEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL- 1800
Query: 440 TYQESEEI-------KSNELDAKLRVTKGELEKQMQEKSDQ---LEMHHAKIKEL----E 485
E+E++ + +L+A++R +GE+E + + ++ L H ++KEL E
Sbjct: 1801 --DEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTE 1858
Query: 486 DLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQ 545
+ ++ D + L+ KVK + + E++ + + + E++ ++ A+
Sbjct: 1859 EDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAES 1918
Query: 546 LQEQLQRGKQEI 557
+L+ +E+
Sbjct: 1919 QVNKLRVKSREV 1930
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 129 bits (324), Expect = 1e-29
Identities = 175/777 (22%), Positives = 337/777 (43%), Gaps = 120/777 (15%)
Query: 152 KIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQ----QEH 207
K V E + + L EF + RV K ++ ++L K + + L+ +
Sbjct: 318 KAVRVDKLESEVSRYKERLHDIEFYKARVEE--LKEDNQVLLETKTMLEDQLEGTRARSD 375
Query: 208 IIKKLIKENKKHQELFVDICSEKDNLREELKKRTE-------TEKQHMNTIKQLESRIEE 260
+ +L KEN + + D+ E+D R+++++ E +KQ M+ L +E+
Sbjct: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435
Query: 261 LNK--EVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEAR---QEKEAMVMKY 315
+++ E+ + + + +V + + L EM + K EE R E K
Sbjct: 436 ISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN--QSLTKTVEELRTTVDSVEGNASKI 493
Query: 316 VRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLI 375
++ EKE+ L K+ E LE ++ + L+ N K L +EK +L + ET + R I
Sbjct: 494 LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 376 REIDKLKEDINSHVIKVKWAQNKLKAE---MDSHKETK---DKLKETTTKLTQAKEEADQ 429
+ +++ E +N V ++ ++++ AE D KE K + +KET++KL++ + E Q
Sbjct: 554 KILEQENEHLNQTVSSLR-QRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQ 612
Query: 430 IRKNCQDMIKTYQESEEI--------KSNELDAK----LRVTKGELEKQMQEKSDQLEMH 477
I+K + + + +EE+ K NEL K L++T ++E QE S
Sbjct: 613 IKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENS------ 666
Query: 478 HAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLL 537
ELE R K+ +D + L +++ LE E + ++E E++ +
Sbjct: 667 -----ELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE-----------NLELRRNV 710
Query: 538 DKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTS 597
+ +K A QLQ +E+E+ KE+++ L ++ S K+ TERL
Sbjct: 711 ESLKCASMKMAQLQLENKELESEKEQLKKGLEL-------LKASFKK-------TERLEV 756
Query: 598 KNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQA 657
L E+ LQ + + QL+S+ + ++ N L+ L+E ++ + ++ L+
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEK 815
Query: 658 ELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEV 717
E + E L ++L+ E +R + + IKD T + + V+ G+ +KE
Sbjct: 816 ENKSLEQETSQLEKDKKQLEKE--NKRLRQQAEIKDTTLE-------ENNVKIGNLEKEN 866
Query: 718 SSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNE 777
++ R ++ + +D I+ +V L++ +
Sbjct: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATID----------IKTLVTLREDLVSEKL 916
Query: 778 KIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTS 837
K + M + +++L E+ +K + + +L +E T R ++ S S
Sbjct: 917 KTQQMNNDLEKLTHEL-EKIGLNKERLLHDEQST-------------DDRYKLLESKLES 962
Query: 838 HPADNGLTLELSLEINRK----LQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHE 890
TL+ SLEI + L+A LE++ N L++ L+T+ E L + Q E
Sbjct: 963 -------TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE 1012
Score = 102 bits (255), Expect = 1e-21
Identities = 148/730 (20%), Positives = 303/730 (41%), Gaps = 141/730 (19%)
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
+K+LI E +H E +++ E+D L H ++ Q + + S
Sbjct: 197 LKRLIDERDEHSETIIELSEERDGLHF---------LPHASSSAQSPCGSPGMKRT--ES 245
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKE 328
R L + AK +++L +E+ ++ EQ + +QE E M ++ R ++E+++L +
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEEKTEQLL----DCKQELEQMEIELKRLQQENMNLLSD 301
Query: 329 KETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSH 388
+ + RD L + ++ +L E R + E R +++LKED N
Sbjct: 302 ARSA-RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR----VEELKED-NQV 355
Query: 389 VIKVKWAQNKLKAEMDSHKETKDKLKETT-------TKLTQAKEEADQIRKNCQDMIKTY 441
+++ K L+ +++ + DKL E KL + E D RK +++++
Sbjct: 356 LLETK---TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
Query: 442 QESEEIKSNELDAKLRV--------TKGELEKQMQEK--SDQLEMHHAKIKELEDLKRTF 491
E + +D L + EL + Q+ + E+ +++ +LE ++
Sbjct: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 492 KEGMDELRTLRTKVKCLEDERLRTEDE---LSKYKEIIN----RQKAEIQNLL----DKV 540
+ ++ELRT V+ + L+ E E LSK EI+ ++K +QN D +
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
Query: 541 KTADQLQEQLQ----RGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLT 596
K QL++ ++ +++I+ L++E E LN ++ L++ + S + + +
Sbjct: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEAR------VKDIE 586
Query: 597 SKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLES------RLLKEEELRKE 650
+N L S+ K+ + Q++ + E K+ E L KE EL ++
Sbjct: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQK 646
Query: 651 EVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVES 710
++ L+ + C + E AL + EL+ E + +K S K+LT QL+ ++ Q++
Sbjct: 647 KITNLK--ITCEKIE--ALEQENSELEREN-RKLKKTLDSFKNLTFQLESLEKENSQLDE 701
Query: 711 GSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQK 770
+ + + R V K
Sbjct: 702 ENLE-----------------------------------------------LRRNVESLK 714
Query: 771 AHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGI 830
+ K +++ ++ E+++K +++++ + E +S + D L +
Sbjct: 715 CASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK---- 770
Query: 831 MASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTL---GTEIERLIKH 887
TLE S + ++L++ L+D ++N TL++NL+ L +E+L K
Sbjct: 771 --------------TLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 888 QHELEQRTKK 897
LEQ T +
Sbjct: 817 NKSLEQETSQ 826
Score = 98.2 bits (243), Expect = 3e-20
Identities = 138/625 (22%), Positives = 270/625 (43%), Gaps = 91/625 (14%)
Query: 154 KSVSASEDLLEEIESELLSTEFAEHRVPNGM------NKGEHALVLFEKCVQDKYLQQEH 207
K++ S ++++ESEL E + + +K L K ++ + Q E
Sbjct: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
Query: 208 IIKKLIKENKK--HQELFVDICSEKDNLR-EELKKRTETEKQHMNTIKQLESRIEELNKE 264
K+L KENK+ Q D E++N++ L+K +T + + K+ R++EL KE
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
Query: 265 VK--------------ASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEA 310
K R+ L+++ + + L K + +E+ E ++++
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK-LTHELEKIGLNKERLLHDEQS 948
Query: 311 MVMKYVRGE-KESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKE- 368
+Y E K L+K E E+K+ LE++TN +QL QE + + YE +
Sbjct: 949 TDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1008
Query: 369 ---------------GETTRLIREIDKLKED---INSHVIKVKWAQNKLKAEMDSHKETK 410
GE + RE + + + +I+V+ L+AE + K T+
Sbjct: 1009 RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALK-TQ 1067
Query: 411 DKLKETTTKLTQAKEEADQIRK-NCQDMIKTYQESE---EIKSNELD----------AKL 456
K ET QA+ A Q + + Q+ T Q +++++ L+ A+L
Sbjct: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
Query: 457 RVTKGELEKQ----MQEKSDQLEMHHAKIKELEDLKRTFKEGMDELR-------TLRTKV 505
+ + LE + ++E+ D ++ + IK+ E L+ + E TL++
Sbjct: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAH 1187
Query: 506 KCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEI-----ENL 560
K LE E ED +Y +++ +QK ++++L +K+ +Q + L+ E + L
Sbjct: 1188 KNLEVEHRDLED---RYNQLL-KQKGQLEDL-EKMLKVEQEKMLLENKNHETVAAEYKKL 1242
Query: 561 KEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSE 620
E + LN + L K+ E + L + +L++E + L+ Q+ ++ +
Sbjct: 1243 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1302
Query: 621 SQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDEL 680
++L +QCE + Q NLE +E +++QTL + + L Q E KD
Sbjct: 1303 TKLNNQCELLSQLKGNLE----EENRHLLDQIQTL-------MLQNRTLLEQNMESKDLF 1351
Query: 681 VTQRRKHASSIKDLTKQLQQARRKL 705
++R++ + +L +Q ++ K+
Sbjct: 1352 HVEQRQYIDKLNELRRQKEKLEEKI 1376
Score = 96.7 bits (239), Expect = 9e-20
Identities = 139/582 (23%), Positives = 266/582 (45%), Gaps = 72/582 (12%)
Query: 379 DKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMI 438
D +EDI + + +L E D H ET +L E L + + C
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 439 KTYQESEEIKSNEL-DAKLRVTKGELEKQMQEKSDQLEMHHAKIKELE-DLKRTFKEGMD 496
ES + S EL DAK ++ + L ++++EK++QL +++++E +LKR +E M+
Sbjct: 240 MKRTESRQHLSVELADAKAKIRR--LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMN 297
Query: 497 EL------RTLRTKVKCLEDERLRT---EDELSKYKE---IINRQKAEIQNLLDK----V 540
L R R ++ L ++ +R E E+S+YKE I KA ++ L + +
Sbjct: 298 LLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 541 KTADQLQEQLQRGK---QEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTS 597
+T L++QL+ + ++ L++E L + ++D++ + + RK+ EL+ E +T
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM--EENMTL 415
Query: 598 KNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMK---QTNINLESRLLK----------- 643
+ AQ QS SL ++ S + S+ Q + N SRLLK
Sbjct: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
Query: 644 EEELRK--EEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQA 701
EELR + V+ +++ + E + LS +VE L++E+V Q ++ + ++L+K L +
Sbjct: 476 VEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV-QEKQSLQNCQNLSKDLMKE 534
Query: 702 RRKLDQV-----------------ESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENT 744
+ +L++ E+ ++ VSS+ RS ++A + +D EN
Sbjct: 535 KAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS----QISAEARVKDIEKENK 590
Query: 745 GSSVAV-DNFPQVDKAMLIERIVRLQKAHAR-KNEKIEFMEDHIKQLVEEIR-KKTKIIQ 801
++ + ++ K +R ++ + H + K E+ E +E+ + L +E + KI
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650
Query: 802 SYILREESGTLSSEASDFNKVHLSRRGGI-----MASLYTSHPADNGLTLELSLEINRKL 856
I E+ L E S+ + + + + + S +N E +LE+ R +
Sbjct: 651 LKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV 710
Query: 857 QAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT 898
++ L+ +K L+ + L +E E+L K L+ KKT
Sbjct: 711 ES-LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
Score = 39.3 bits (90), Expect = 0.017
Identities = 42/169 (24%), Positives = 73/169 (43%), Gaps = 29/169 (17%)
Query: 200 DKYLQQEHIIKKLIKENKKHQELFVD---ICSEKDNLRE---ELKKRTETEKQHMNTIKQ 253
+K L+ E +K++ ENK H+ + + +C E D L +L K TE + +K
Sbjct: 1215 EKMLKVEQ--EKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1272
Query: 254 L--ESRIEELNKEVKASR--DQLIAQDVTAKNAVQQ--LHKEMAQRMEQANKKCEEARQE 307
L S++E+ E + S+ +Q D+T+ Q L ++ +E+ N+ + Q
Sbjct: 1273 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1332
Query: 308 KEAMVMKYVRGEKESLDL---------------RKEKETLEKKLRDANK 341
+ ES DL R++KE LE+K+ D K
Sbjct: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1381
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 129 bits (323), Expect = 2e-29
Identities = 167/830 (20%), Positives = 373/830 (44%), Gaps = 93/830 (11%)
Query: 107 KTNETEQKVTQILVELRSSTFPESANEKTYS--ESPYDTDCTKKFISKIKSVSAS----- 159
K + EQ+V + +L+ S E EK + E + D TK+ + +++ S
Sbjct: 447 KLMDKEQQVADL--QLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKL 504
Query: 160 EDLLEEIESELLSTEFAEHRVPNG---MNKGEHALVLFEKCVQDKYLQ------QEHIIK 210
+ ++E L + ++ N + K + + L EK +D Y + + ++
Sbjct: 505 REAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 211 KLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRD 270
+L ++N QE + L E+LK ++E+ KQ + L +++E ++A++D
Sbjct: 565 QLQEKNHTLQE-------QVTQLTEKLKNQSESHKQAQ---ENLHDQVQEQKAHLRAAQD 614
Query: 271 QLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKE 330
++++ + + V +L+ ++ + E+ ++ + + + E ++ + DL+ +
Sbjct: 615 RVLSLETS----VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD 670
Query: 331 TLEKKLRDANKELEKNTNKIKQLS---QEKGRLHQLYETKEGETTRLIREIDKLKEDINS 387
T + L+D +EL K T ++ Q++ Q+K E+ E +++ E++
Sbjct: 671 TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG 730
Query: 388 HVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEI 447
+ K++ ++KA + + + ++ T L E + + ++++ + + +
Sbjct: 731 QIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQK 790
Query: 448 KSNELDA-KLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVK 506
KS L++ K ++TK E EKQ+ ++ + KI+ E+L + + EL+ ++ + +
Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH-EELNNRIQTTVTELQKVKMEKE 849
Query: 507 CLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVES 566
L E +D+LSK + + K+E +++ Q+GK I +L++ +
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSKSE-------------FEKENQKGKAAILDLEKTCKE 896
Query: 567 LNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQ 626
L + LQ +E + K + EL E+ + QL+ E NS+Q Q + + Q + +
Sbjct: 897 LK---HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 627 CEQMKQTNINLESRLLKEEELRKEEVQTLQAEL---ACRQTEVK-ALSTQVEELKDELVT 682
EQ Q NIN L + E +K++++ LQ EL ++TE++ L Q+ + EL
Sbjct: 954 -EQQLQGNIN---ELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAA 1009
Query: 683 QRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPE 742
++ K I L ++++ Q++S Y +E + +R S A++
Sbjct: 1010 EKEK----ISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED--- 1062
Query: 743 NTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKN--EKIEFMEDHIKQLVEEIRKKTKII 800
+ N Q+ + + ++ KA ++ +K + +++ K L ++I+K+ +
Sbjct: 1063 ------LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKAL-QDIQKEKSLK 1115
Query: 801 QSYILREESGTLSSE------ASDFNKVHLSRRGGIMASL--YTSHPADNGLTLELSLEI 852
+ ++ E+S E + K++ + + S+ T+ L ++ LE+
Sbjct: 1116 EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175
Query: 853 NRK---LQAVLE-----DTLLKNITLKENLQTLGTEIERLIKHQHELEQR 894
K L+A +E +LK+ KE + IE+ K E++++
Sbjct: 1176 QGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEK 1225
Score = 115 bits (289), Expect = 1e-25
Identities = 154/777 (19%), Positives = 340/777 (43%), Gaps = 79/777 (10%)
Query: 163 LEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQEL 222
L++++S + + + K E E+ ++ + +++I L +++ Q+L
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 223 FVDICSEKDNLRE---ELKKRTETEKQHMNTIKQLESRIEELN---KEVKASRDQLIAQD 276
+ + + +L EL ++ E ++ + ++E++ + L K+++ R++
Sbjct: 350 QSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHG 409
Query: 277 VTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKL 336
+ ++ + QLH ++ + Q + +++++ K + E++ DL+ + LE++L
Sbjct: 410 LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQL 469
Query: 337 RDA---NKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVK 393
++ + EL+ +K KQ QE+ L Q TT +RE
Sbjct: 470 KEKVTNSTELQHQLDKTKQQHQEQQALQQ-------STTAKLRE---------------- 506
Query: 394 WAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQ--ESEEIKSNE 451
AQN L+ + + K++ L ++KE + K +D+ Q E E N+
Sbjct: 507 -AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 565
Query: 452 LDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELED----LKRTFKEGMDELRTLRTKVKC 507
L K + ++ + ++ +Q E H + L D K + D + +L T V
Sbjct: 566 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE 625
Query: 508 LEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTA---------DQLQEQLQRGKQEIE 558
L + +++++S+ +I + K E+ + KTA D Q LQ +QE+
Sbjct: 626 LNSQLNESKEKVSQL-DIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN 684
Query: 559 NLKEEVESLNSLINDLQKDIEGSRKRESELLLFTER---LTSKNAQLQSESNSLQSQFDK 615
+ +++ + + + D Q E + ES L + E+ L K +L+ + L++ +
Sbjct: 685 KITTQLDQVTAKLQDKQ---EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 616 VSCSESQLQSQCEQMKQTNINLESR---LLKEEELRKEEVQTLQAELACRQTEVKA---- 668
V S+ Q +Q +Q N +LE R L K+ E+ KE V + + +L + +++
Sbjct: 742 VKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK 801
Query: 669 LSTQVEE---LKDELVTQRRKHASSIKDLTKQLQQARRKLDQV--ESGSYDKEVSSMGSR 723
L+ Q EE LK + T ++ ++L ++Q +L +V E + E+S++ +
Sbjct: 802 LTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
Query: 724 SSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFME 783
S S + ++S + EN A+ + + K + + V+++ + E + +E
Sbjct: 862 LSKV-SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLE 920
Query: 784 DHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNG 843
K+ +++ + +Q +++ ++ +E K +G I +S
Sbjct: 921 KE-KEASHQLKLELNSMQEQLIQAQNTLKQNE-----KEEQQLQGNINELKQSSEQKKKQ 974
Query: 844 L-TLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERL--IKHQHELEQRTKK 897
+ L+ L+I + LE+ L + +T + Q L E E++ +++ +E Q T K
Sbjct: 975 IEALQGELKIAVLQKTELENKLQQQLT--QAAQELAAEKEKISVLQNNYEKSQETFK 1029
Score = 110 bits (274), Expect = 8e-24
Identities = 148/659 (22%), Positives = 313/659 (47%), Gaps = 63/659 (9%)
Query: 106 SKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEE 165
S+ NE+++KV+Q+ +++++ T + E + D + +++ L++
Sbjct: 628 SQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQ---------NHLDTAQNALQD 678
Query: 166 IESELLS-TEFAEHRVPNGMNKGEHALVLFE--KCVQDKYLQQEHIIKKLIKENKKHQEL 222
+ EL T + +K EH L K ++KYL E ++L + KK +
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738
Query: 223 FVDICSEKDNLREELKKR----TETEKQHMNTIKQLESRIE-----ELNKEVKASRDQLI 273
+++ + K+ ++L+++ T+ E + KQLE E L+ + K+ + I
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 274 AQDVTAKNAVQQLHKEMAQRMEQANK-KCEEARQEKEAMVMKYVRGEKESLDLRKEKETL 332
Q +T + +Q+ K+ + + Q K + EE + V + + + E L E T+
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858
Query: 333 EKKLRDANKELEKNTNKIKQLSQE-KGRLHQLYET-KEGETTRLIREIDKLKE--DINSH 388
+ KL + L+ + ++ ++ +Q+ K + L +T KE + ++ + LKE ++
Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
Query: 389 VIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTY-QESEEI 447
+ K K A ++LK E++S +E +L + L Q ++E Q++ N ++ ++ Q+ ++I
Sbjct: 919 LEKEKEASHQLKLELNSMQE---QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 448 KSNELDAKLRVT-KGELEKQMQEKSDQLEMHHAKIKE-LEDLKRTFKEGMDELRTLRTKV 505
++ + + K+ V K ELE ++Q++ Q A KE + L+ +++ + + L++
Sbjct: 976 EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 506 KCLEDERLRTEDELSKYKE---------IINRQKAEIQN-LLDKVKTAD--------QLQ 547
E E L T +L +E I NR + QN L+ ++KTA + +
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
Query: 548 EQLQRGKQEIENLKEEVESLNS--LINDLQK--DIEGSR-KRESELLLFTERLTSKNAQL 602
+QLQ + ++++++E +SL L+N+ K +IE + ++E E+ E L S +
Sbjct: 1096 QQLQERCKALQDIQKE-KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154
Query: 603 QSESNSLQSQFDKVSCSESQLQSQC-------EQMKQTNINLESRLLKEEELRKEEVQTL 655
E +L+ + + +LQ + EQ K+ L+ ++ KEEE K+E
Sbjct: 1155 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEK 1214
Query: 656 QAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYD 714
+A+L E + + EE + +L Q ++ + K+ Q ++R++ ++E + D
Sbjct: 1215 EAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDD 1273
Score = 92.8 bits (229), Expect = 1e-18
Identities = 141/737 (19%), Positives = 302/737 (40%), Gaps = 107/737 (14%)
Query: 44 LLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGG--------EDSCAKTDTGSENSEQIAN 95
LLS KT Q + N ++ +N + D + AK E+ Q+ +
Sbjct: 651 LLSAEAAKT-AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 709
Query: 96 FPSGNFAKHIS---KTNETEQKVTQILVE-LRSSTFPESANEKTYSESPYDTDCTKKFIS 151
K++S KT E E ++ ++ + L E A + + +TD +
Sbjct: 710 HLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATE 769
Query: 152 KIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVL----FEKCVQDKYLQQEH 207
K + ++++ +L A + + K E + FE Q+ +Q E
Sbjct: 770 LSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEE 829
Query: 208 IIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKA 267
+ ++ + Q++ + EK+ L EL + + +++K +S E+ N++ KA
Sbjct: 830 LNNRIQTTVTELQKVKM----EKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKA 885
Query: 268 SRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRK 327
+ ++ + T K QL +M +++ + + +EKEA + L +
Sbjct: 886 A---ILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942
Query: 328 EKETLEKKLRDANKELEKNTNKIKQLSQEK--------GRLHQLYETKEGETTRLIREID 379
+ TL++ ++ ++L+ N N++KQ S++K G L K +L +++
Sbjct: 943 AQNTLKQNEKE-EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT 1001
Query: 380 KLKEDINSHVIKVKWAQNKLKAEMDSHKE--------------TKDKLKETTTKLTQAKE 425
+ +++ + K+ QN + ++ K+ T+ LK KL+ A+E
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 426 EADQIRKNCQDMIKTYQESEEIKSN----------ELDAKLRVTKGELEKQMQEKSDQLE 475
+ R + K QE + K+ +L + + + +++K+ K +L
Sbjct: 1062 DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQ-DIQKEKSLKEKELV 1120
Query: 476 MHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQN 535
+K+ E+E++K ++ E+ L ++K + E ++ L K+++ +QK E+Q
Sbjct: 1121 NEKSKLAEIEEIKCRQEK---EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQG 1177
Query: 536 LLDKVKTADQLQEQLQR-----GKQEIENLKEE--------------------------- 563
D +K A + +++ Q+ K+E E LK+E
Sbjct: 1178 KADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEA 1237
Query: 564 -----VESLNSLINDLQKDIEGSRKRESELLLFTERLTSK----NAQLQSESNSLQSQFD 614
+ +LN + ++K+ + S++R SEL T+ L + A +Q+ + ++ +
Sbjct: 1238 KLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLE 1297
Query: 615 KVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVE 674
+ E +++ ++ + L++ +EL +E Q+LQ + A +V+
Sbjct: 1298 RCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGREN-QSLQIKHTQALNRKWAEDNEVQ 1356
Query: 675 EL----KDELVTQRRKH 687
K VT RR H
Sbjct: 1357 NCMACGKGFSVTVRRHH 1373
Score = 81.6 bits (200), Expect = 3e-15
Identities = 118/575 (20%), Positives = 249/575 (43%), Gaps = 67/575 (11%)
Query: 261 LNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKK--CEEARQEKEAMVMKYVRG 318
L +EV+ + L + ++ ++L K + ++A ++ E +++ +
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
Query: 319 EKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREI 378
+ E+ ++++ K+ E+K E+ IK E+ L E E + TRL E+
Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIAD----IKSKYDEE---RSLREAAEQKVTRLTEEL 200
Query: 379 DKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKE-EADQIRKNCQDM 437
+K I +K + Q ++ K+ +++ +T +E E+++++ C+ +
Sbjct: 201 NKEATVIQD--LKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL 258
Query: 438 IKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDE 497
Y SE A + + EL K QE + ++EL+ LK + E
Sbjct: 259 QSQYASSE--------ATISQLRSELAKGPQEVA-------VYVQELQKLKSSVNE---- 299
Query: 498 LRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEI 557
L K + L + L+ E + +K +E N + +N+ + D +QLQ
Sbjct: 300 ---LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ------ 350
Query: 558 ENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVS 617
L SL+ + +L + E ++K + EL + +K L++E LQ Q ++
Sbjct: 351 SRLSASETSLHRIHVELSEKGEATQKLKEEL----SEVETKYQHLKAEFKQLQQQREEKE 406
Query: 618 CSESQLQSQCEQMKQTNINLESRL------LKEEEL--------RKEEVQTLQAELACRQ 663
QLQS+ Q+ + E +L LKE+ ++++V LQ +L+ +
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
Query: 664 TEVKALSTQVEELKDELVTQRRKHASS---IKDLTKQLQQARRKLDQV--ESGSYDKEVS 718
++K T EL+ +L +++H + T +L++A+ L+QV + G D+++
Sbjct: 467 EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 526
Query: 719 SMGS---RSSSSGSLNARSSAEDRSPENTG-SSVAVDNFPQVDKAMLIERIVRLQKAHAR 774
++ + +S + SL + + + G AV N Q L E++ +L +
Sbjct: 527 NLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKN 586
Query: 775 KNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREES 809
++E + ++++ V+E + + Q +L E+
Sbjct: 587 QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621
Score = 64.7 bits (156), Expect = 4e-10
Identities = 105/501 (20%), Positives = 216/501 (43%), Gaps = 62/501 (12%)
Query: 9 STSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQEN 68
ST DK + LK S +E K + K L+ +KT C+ +H +++ EN
Sbjct: 856 STVKDKLSKVSDSLKN------SKSEFEKENQKGKAAILDLEKT-CKELKHQLQVQ-MEN 907
Query: 69 YIPDHGGGEDSCAKTDTGSE------NSEQIANFPSGNFAKHISKTNE------------ 110
+ + + S K S NS Q + N K K +
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
Query: 111 TEQKVTQI-------LVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKS-VSASEDL 162
+EQK QI + + T E+ ++ +++ + K+ IS +++ S++
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQET 1027
Query: 163 LEEI-------ESELLSTEFAEHRVPNGMNKGEHALVLFEKCV--QDKYLQQEHIIKKLI 213
+++ ESELL+T V ++ + L+ + Q+K +Q+ K +
Sbjct: 1028 FKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1087
Query: 214 KEN--KKHQELFVDICSEKDNLREELKKRTE--TEKQHMNTIKQLESR----IEELNKEV 265
+++ KK Q+L + +D +E+ K E EK + I++++ R I +LN+E+
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL 1147
Query: 266 KASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDL 325
K+ + + I + K+A Q L ++ + +A+ QEK + + +KE +L
Sbjct: 1148 KSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL 1207
Query: 326 RKEKETLEKKLRDANKELE-----------KNTNKIKQLSQEKGRLHQLYETKEGETTRL 374
+KE E KL KE E K T +I L++ G + + +++ + + L
Sbjct: 1208 KKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSEL 1267
Query: 375 IREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNC 434
++ D L+ +I V+ Q++ +A ++ + + ++++ TK+ + + + D
Sbjct: 1268 EKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAV 1327
Query: 435 QDMIKTYQESEEIKSNELDAK 455
Q++ + Q + + L+ K
Sbjct: 1328 QELGRENQSLQIKHTQALNRK 1348
Score = 53.1 bits (126), Expect = 1e-06
Identities = 84/397 (21%), Positives = 167/397 (42%), Gaps = 72/397 (18%)
Query: 516 EDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLIND-- 573
E L+ ++ + + E+Q+L +K E+L++ ++ + L+++ + L+ D
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 574 -----LQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCE 628
L++ +E ++ + + K AQL +E ++S++D+ E L+ E
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDE----ERSLREAAE 190
Query: 629 QMKQTNINLESRLLKEEELRKEE--VQTLQAELACRQ-----TEVKALSTQVEELKDELV 681
Q K T + EEL KE +Q L+ EL R +K QV+ L D +
Sbjct: 191 Q-KVTRLT--------EELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMT 241
Query: 682 TQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSP 741
+R + + +KD K+LQ +SS +++ S + P
Sbjct: 242 LERERESEKLKDECKKLQ---------------------SQYASSEATISQLRSELAKGP 280
Query: 742 ENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQ 801
+ VAV + LQK + NE + + + L+++ + TK+ +
Sbjct: 281 Q----EVAV-------------YVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
Query: 802 SYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSL--EINRKLQAV 859
+ EES + + + ++ L + + + L S + + + +ELS E +KL+
Sbjct: 324 KH--NEESVSKKNIQATLHQKDLDCQ-QLQSRLSASETSLHRIHVELSEKGEATQKLKEE 380
Query: 860 LEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTK 896
L + K LK + L + E K QH L+ +++
Sbjct: 381 LSEVETKYQHLKAEFKQLQQQREE--KEQHGLQLQSE 415
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 126 bits (317), Expect = 8e-29
Identities = 141/553 (25%), Positives = 273/553 (49%), Gaps = 71/553 (12%)
Query: 198 VQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESR 257
+Q + +QE+++K+ + + H+E + SEK+ L+E+L +R Q + IK L
Sbjct: 284 LQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERL----QELEKIKDLH-- 337
Query: 258 IEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMV----- 312
A + +LI Q AKN ++QL ++ + + ++ E + KE +
Sbjct: 338 --------MAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS 389
Query: 313 -MKYVRGEKESLDLRKEK------ETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYE 365
+K + + E L +KEK E LEK L A K E+ K+K E ++ + +
Sbjct: 390 RIKQMTTQGEELREQKEKSERAAFEELEKALSTAQK-TEEARRKLKAEMDE--QIKTIEK 446
Query: 366 TKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKL-TQAK 424
T E E L +E+ ++K+++ V+K + K + KE K +E T KL T+ +
Sbjct: 447 TSEEERISLQQELSRVKQEV-VDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER 505
Query: 425 EEADQIR----KNCQDMIKTYQESEEIKS---NELDAKLRVTKGELEKQMQEKSDQLEMH 477
E +Q++ K+ + +K QE E+ +S EL+ + + E E ++++ + E +
Sbjct: 506 EFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETY 565
Query: 478 HAKIKELE-DLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNL 536
+I ELE L+++ +E ++ + L LE E+ + E++ ++ + K E+++L
Sbjct: 566 RTRILELESSLEKSLQENKNQSKDLAVH---LEAEKNKHNKEIT---VMVEKHKTELESL 619
Query: 537 LDKVKT--ADQLQEQLQRGKQEIENLKEEVE-SLNSLINDLQKDIEGSRKRESELLLFTE 593
+ ++LQ Q+ + E+E L+E+ E +L+ D + + + +E L E
Sbjct: 620 KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTL--E 677
Query: 594 RLTSKNAQLQSESNSLQSQF---DKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKE 650
+L K +L+S S+ L K+ S L+ Q ++MKQ LE+++ +++ ++
Sbjct: 678 KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ---ELEAKMDEQKNHHQQ 734
Query: 651 EVQTL--QAELACRQTEVKALSTQVEELKDELVTQRRKH-----------ASSIKDLTKQ 697
+V ++ + E++ ++TE KAL Q+ +L + L+ +R KH + IK +
Sbjct: 735 QVDSIIKEHEVSIQRTE-KALKDQINQL-ELLLKERDKHLKEHQAHVENLEADIKRSEGE 792
Query: 698 LQQARRKLDQVES 710
LQQA KLD +S
Sbjct: 793 LQQASAKLDVFQS 805
Score = 105 bits (261), Expect = 2e-22
Identities = 133/628 (21%), Positives = 281/628 (44%), Gaps = 81/628 (12%)
Query: 214 KENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLI 273
+ K + L + C+ + L +L++ TE + + +Q ++EE ++K+ + I
Sbjct: 1256 RTTKVKEALLIKTCTVSE-LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD-I 1313
Query: 274 AQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLE 333
VT K A+Q+ Q + + ++E + ++E + + E +L
Sbjct: 1314 ESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLS 1373
Query: 334 KKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKL--------KEDI 385
K+L D N +L+ + + LS+++ + L + + E L+ ++ L KE I
Sbjct: 1374 KQLTDLNVQLQNSIS----LSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429
Query: 386 NSHVIKVKWA------QNKLKAEMDSHKETKDKLK-ETTTKLTQAKEEADQIRKNCQDMI 438
++ W+ + K ++ H+ T +L+ + K +A E+ +QI +++
Sbjct: 1430 SALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI-----NLL 1484
Query: 439 KTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELED--LKRTFK-EGM 495
K + + + + L ++ K ++EK+ +L+ A+I ELED ++T + E +
Sbjct: 1485 KEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESL 1544
Query: 496 DELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQ 555
+E+ + K +E + L +L ++E+ + ++ +K+ T L+ Q+ K
Sbjct: 1545 NEVLKNYNQQKDIEHKEL--VQKLQHFQELGEEKDNRVKEAEEKILT---LENQVYSMKA 1599
Query: 556 EIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDK 615
E+E K+E+E +N + + +E EL +RL S++A +E Q K
Sbjct: 1600 ELETKKKELEHVNLSV----------KSKEEELKALEDRLESESAAKLAELKRKAEQ--K 1647
Query: 616 VSCSESQLQSQCEQMKQTNINLESRLLKEEELRK---EEVQTLQAELACRQTEVKALSTQ 672
++ + QL SQ E+ KEE+ +K + L +L R+ EV L +
Sbjct: 1648 IAAIKKQLLSQMEE-------------KEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
Query: 673 VEELK----DELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSG 728
++ ++ + L+ R S K++ +Q +Y++++S + +
Sbjct: 1695 LKSVESSQSETLIVPR-----SAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKE 1749
Query: 729 SLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQ 788
L R E E T SS +F + ER+++L+ A A+++E + M H+++
Sbjct: 1750 KLLQRVGQEK---EETVSS----HFEM--RCQYQERLIKLEHAEAKQHED-QSMIGHLQE 1799
Query: 789 LVEEIRKKTKIIQSYILREESGTLSSEA 816
+EE KK +I + + +E G + +A
Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQA 1827
Score = 103 bits (256), Expect = 9e-22
Identities = 177/931 (19%), Positives = 365/931 (39%), Gaps = 120/931 (12%)
Query: 34 ESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGG-----EDSCAKTDTGSE 88
E + + KLL L T++ L + +EAQ+ + +D + + +
Sbjct: 818 EEQLAQLQQKLLDLETERILL--TKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS 875
Query: 89 NSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKK 148
EQ + + + N+ +++ QILVE + +K K+
Sbjct: 876 EMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQK------------KE 923
Query: 149 FISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHI 208
+ +SA ED + + E E + N K EK Q QE +
Sbjct: 924 IEILTQKLSAKEDSIHILNEEY------ETKFKNQEKK-------MEKVKQKAKEMQETL 970
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELK-KRTETEKQHMNTIKQLESRIEELNKEVKA 267
KKL+ + K ++ + E ++ K E + + I SR+E KE
Sbjct: 971 KKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE 1030
Query: 268 SRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRK 327
S ++ +++ + + K++ Q+ E+ + E QEKE V + +++ L
Sbjct: 1031 SLTEVHRRELN--DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAEL---KQKILLFGC 1085
Query: 328 EKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINS 387
EKE + K++ +E K + +L ++ + + + T+L ++KL+ D+N
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNK 1145
Query: 388 HVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQE-SEE 446
+ + + Q +L +E K K+ E T+KL EE ++ + + K+ ++ S E
Sbjct: 1146 SLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLE 1205
Query: 447 IK--SNELDAKLRVTKGELEKQMQEKSDQL------------------EMHHAKIKELED 486
K S EL +L + + E ++ K+++L + K+KE
Sbjct: 1206 FKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALL 1265
Query: 487 LKR-TFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLL-------- 537
+K T E +LR L + L + +L + + I KA+I++L+
Sbjct: 1266 IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQK 1325
Query: 538 ----------DKVKTADQLQEQLQRG-------KQEIENLKEEVESLNSLINDLQKDIEG 580
+K QL+++L K+E++ K E+ SL+ + DL ++
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN 1385
Query: 581 S---RKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINL 637
S ++E+ + ++ + +L + L + D +S + Q +
Sbjct: 1386 SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
Query: 638 ESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQ 697
+ + + V+ LQ +L + E Q+ LK+EL Q ++ L +
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKR----FDCLKGE 1501
Query: 698 LQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQ-- 755
++ + K+++ ES + + E+ S +R + ++ E + + N+ Q
Sbjct: 1502 MEDDKSKMEKKES-NLETELKSQTAR-----IMELEDHITQKTIEIESLNEVLKNYNQQK 1555
Query: 756 -VDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSS 814
++ L++++ Q+ K+ +++ E+ I L ++ Y ++ E T
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV---------YSMKAELETKKK 1606
Query: 815 EASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKE-- 872
E N S+ + A EL + +K+ A ++ LL + KE
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKI-AAIKKQLLSQMEEKEEQ 1665
Query: 873 -------NLQTLGTEIERLIKHQHELEQRTK 896
+L L T+++ + H LE++ K
Sbjct: 1666 YKKGTESHLSELNTKLQEREREVHILEEKLK 1696
Score = 94.0 bits (232), Expect = 6e-19
Identities = 151/701 (21%), Positives = 301/701 (42%), Gaps = 95/701 (13%)
Query: 77 EDSCAKTDTGSENS----EQIANFPSGNFAKHISKT------NETEQKVTQILVELRSST 126
+D K DT S+ EQ+ ++ S F++ K ++ K QI +EL+S
Sbjct: 1415 QDLSFKVDTLSKEKISALEQVDDW-SNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKE 1473
Query: 127 FPESANEKTYSESPYDT-----DCTKKFISKIKS-VSASEDLLE-EIESELLSTEFAEHR 179
E + + D DC K + KS + E LE E++S+ E
Sbjct: 1474 AYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDH 1533
Query: 180 VPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKK 239
+ + E + + Q K ++ + +++KL + F ++ EKDN +E ++
Sbjct: 1534 ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL--------QHFQELGEEKDNRVKEAEE 1585
Query: 240 RTETEKQHMNTIK-QLESR---IEELNKEVKASRDQLIAQD--VTAKNAVQ--QLHKEMA 291
+ T + + ++K +LE++ +E +N VK+ ++L A + + +++A + +L ++
Sbjct: 1586 KILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAE 1645
Query: 292 QRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLR-----KEKETLEKKLRDANKELEKN 346
Q++ K+ +EKE K L+ + +E LE+KL+ +
Sbjct: 1646 QKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSET 1705
Query: 347 T-------NKIKQLSQEK----GRLHQLYETKEGETTRLIREIDKL--------KEDINS 387
N QE+ G + + YE K R + E +KL +E ++S
Sbjct: 1706 LIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSS 1765
Query: 388 HV-IKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEE 446
H ++ ++ + +K E H E K E + + +EE ++ K ++ + E E
Sbjct: 1766 HFEMRCQYQERLIKLE---HAEAKQH--EDQSMIGHLQEELEEKNKKYSLIVAQHVEKEG 1820
Query: 447 IKSN-ELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDL----KRTFKEGMDELRTL 501
K+N + L +++K +QEK ++ KIKEL+ K + M+EL +
Sbjct: 1821 GKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSK 1880
Query: 502 RTKVKCLEDERLRTEDELSKYKEIINRQKAE-IQNLLDKVKTADQLQEQLQRGKQEIENL 560
K++ L+ D +K E++ E ++ L + K ++ Q + ++
Sbjct: 1881 YEKLQALQQM-----DGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGA 1935
Query: 561 KEEVESLNSLINDLQKDIEGSRKRESELLLFT---------ERLTSKNAQLQSESNS-LQ 610
+ E + L I LQKD+ RK + L E++ + L+ + NS L+
Sbjct: 1936 EREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLK 1995
Query: 611 SQFDKVSCSESQLQSQCEQMKQTNIN----LESRLLKEEELRKEEVQTLQAELACRQTEV 666
+ + +Q + + E + IN +E+ LL E +EE L ++A + ++
Sbjct: 1996 QLMREFNTQLAQKEQELEMTIKETINKAQEVEAELL---ESHQEETNQLLKKIAEKDDDL 2052
Query: 667 KALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQ 707
K + + EE+ D + + + ++DL QL++ ++K Q
Sbjct: 2053 KRTAKRYEEILD---AREEEMTAKVRDLQTQLEELQKKYQQ 2090
Score = 84.3 bits (207), Expect = 5e-16
Identities = 135/672 (20%), Positives = 297/672 (44%), Gaps = 91/672 (13%)
Query: 274 AQDVTAKNAVQQLHKE-MAQRMEQANKKCEEARQEKEAMVMKY--VRGEKESLD--LRKE 328
A+D+ + L+KE + QR+ + + R + +V Y ++ EK+ L L +
Sbjct: 124 AEDLVGNS--DSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQS 181
Query: 329 KETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSH 388
++ +++ + +EL+ + K L +E E K+ + L ++ LK+ + +
Sbjct: 182 QDKSLRRIAELREELQMDQQAKKHLQEE---FDASLEEKDQYISVLQTQVSLLKQRLRNG 238
Query: 389 VIKVKWAQNKLKAEMDSHKETKDKLKE--------------TTTKLTQAKEEADQIRKNC 434
+ V + + E + TK++ E T L Q + + + K C
Sbjct: 239 PMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRC 298
Query: 435 QDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEG 494
++ I++++E + ++E +A L++Q+ E+ +LE KIK+L ++T +
Sbjct: 299 KETIQSHKEQCTLLTSEKEA--------LQEQLDERLQELE----KIKDLHMAEKT--KL 344
Query: 495 MDELRTLRTKVKCLE-DERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRG 553
+ +LR + ++ LE D+ + + + E + ++ EI L ++K E+L+
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQ 404
Query: 554 KQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQF 613
K++ E + E L ++ QK E RK ++E+ E++ + + E SLQ +
Sbjct: 405 KEKSE--RAAFEELEKALSTAQKTEEARRKLKAEM---DEQIKTIEKTSEEERISLQQEL 459
Query: 614 DKVS---------CSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQT-LQAELACRQ 663
+V SE Q+ + ++ E L K+ + R+ E Q ++ L Q
Sbjct: 460 SRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQ 519
Query: 664 TEVKALSTQVEELK----DELVTQRR----KHASSIKDLTKQLQQARRKLDQVESGSYDK 715
+E +S + E+ + +EL Q++ + + ++DL ++ + R ++ ++ES S +K
Sbjct: 520 SEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES-SLEK 578
Query: 716 EVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARK 775
S+ + S L AE ++ N +V V+ +++ ++ A
Sbjct: 579 ---SLQENKNQSKDLAVHLEAE-KNKHNKEITVMVEKHKTELESLKHQQ-------DALW 627
Query: 776 NEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLY 835
EK++ ++ + +E++R+K + + +L+++ + + N+ L + L
Sbjct: 628 TEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEK-------LD 680
Query: 836 TSHPADNGLTLELSLEINRKLQAVLEDTLLKNIT--LKENLQTLGTE--------IERLI 885
L+ ELS + + + E ++LK+ T +K+ L+ E ++ +I
Sbjct: 681 VKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740
Query: 886 KHQHELEQRTKK 897
K QRT+K
Sbjct: 741 KEHEVSIQRTEK 752
Score = 64.3 bits (155), Expect = 5e-10
Identities = 128/676 (18%), Positives = 280/676 (41%), Gaps = 104/676 (15%)
Query: 284 QQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDAN--- 340
++L +++++ +Q + A+ + +R S + ++ T ++ D
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFA 62
Query: 341 KELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLK 400
++L+ ++ L + + L+ + E+ L+R + E +N + A
Sbjct: 63 QKLQLRVPSVESLFRSPIK-ESLFRSSSKES--LVRTSSR--ESLNRLDLDSSTASFDPP 117
Query: 401 AEMDSHKE----TKDKL--KETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDA 454
++MDS E D L ++ +L + + R +++ YQ + K +L
Sbjct: 118 SDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKK-KLQG 176
Query: 455 KLRVTKGELEKQMQEKSDQLEMHHAKIKEL-EDLKRTFKEGMDELRTLRTKVKCLED--- 510
L ++ + +++ E ++L+M K L E+ + +E + L+T+V L+
Sbjct: 177 ILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR 236
Query: 511 ------ERLRTEDELSKYKEIINRQK---AEIQNLLD---KVKTADQLQEQLQRGKQEIE 558
+ L+ +L E+ +++ ++ + +++ VKT + LQ++++R + ++
Sbjct: 237 NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLK 296
Query: 559 NLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSC 618
KE ++S L + E +++ E L E++ + +E L +Q
Sbjct: 297 RCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLH---MAEKTKLITQLR---- 349
Query: 619 SESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKD 678
L Q EQ K I R + E KEE E+A ++ +K ++TQ EEL++
Sbjct: 350 DAKNLIEQLEQDKGMVIAETKRQMHETLEMKEE------EIAQLRSRIKQMTTQGEELRE 403
Query: 679 ELVTQRRKHASSIKDLTKQL------QQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNA 732
+ + + ++ ++L K L ++ARRKL D+++ ++
Sbjct: 404 Q---KEKSERAAFEELEKALSTAQKTEEARRKL----KAEMDEQIKTI-----------E 445
Query: 733 RSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAH----ARKNEKI--------- 779
++S E+R S V K E+I +LQK H ARK +++
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER 505
Query: 780 EFME-----------DHIKQLVEEIRKKTKIIQSYILREES---------GTLSSEASDF 819
EF E +++K E+ ++++ ++ L++++ L EA +
Sbjct: 506 EFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETY 565
Query: 820 NKVHLSRRGGIMASLYTSHPADNGLTLELSLE---INRKLQAVLEDTLLKNITLKENLQT 876
L + SL + L + L E N+++ ++E + +LK
Sbjct: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA 625
Query: 877 LGTEIERLIKHQHELE 892
L TE +++K Q++ E
Sbjct: 626 LWTEKLQVLKQQYQTE 641
Score = 62.0 bits (149), Expect = 2e-09
Identities = 94/458 (20%), Positives = 191/458 (41%), Gaps = 48/458 (10%)
Query: 107 KTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEI 166
K+ E+ Q T I+ + + E+ S+ +K ++++ E LL+ +
Sbjct: 1696 KSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRV 1755
Query: 167 ---ESELLSTEFAEH-RVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQEL 222
+ E +S+ F + + K EHA E + H+ ++L ++NKK+ L
Sbjct: 1756 GQEKEETVSSHFEMRCQYQERLIKLEHA----EAKQHEDQSMIGHLQEELEEKNKKYS-L 1810
Query: 223 FVDICSEKDNLREELKKRTETEKQH---MNTIKQLESRIEELNKEVKASRDQLIAQDVTA 279
V EK+ + ++ + E T+++ E + L +++K L+ Q
Sbjct: 1811 IVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVH 1870
Query: 280 KNAVQQLHK-----EMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEK 334
+ +++L + Q+M+ NK E + E ++ K ++ + LE
Sbjct: 1871 RVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEF 1930
Query: 335 KLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREID-----KLKEDINSHV 389
KL A +E +K +I +L ++ L L + + E L +E D K+K++
Sbjct: 1931 KLAGAEREKQKLGKEIVRLQKD---LRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLE 1987
Query: 390 IKVKWAQNKLKAEMDSH------------KETKDKLKETTTKLTQA-KEEADQIRKNCQD 436
+K +L E ++ KET +K +E +L ++ +EE +Q+ K +
Sbjct: 1988 LKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAE 2047
Query: 437 M-------IKTYQESEEIKSNELDAKLR---VTKGELEKQMQEKSDQLEMHHAKIKELED 486
K Y+E + + E+ AK+R EL+K+ Q+K +Q E + +
Sbjct: 2048 KDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIME 2107
Query: 487 LKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKE 524
L+ + + + K + ++ ED L KY++
Sbjct: 2108 LQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
Score = 50.8 bits (120), Expect = 6e-06
Identities = 84/363 (23%), Positives = 158/363 (43%), Gaps = 33/363 (9%)
Query: 34 ESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGSENSEQI 93
E+ + E++S + L + L + N+ + I AQ ++ GG + AK +N E +
Sbjct: 1784 EAKQHEDQSMIGHLQEE--LEEKNKKYSLIVAQ--HVEKEGGKNNIQAK-----QNLENV 1834
Query: 94 ANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKI 153
+ + K + + T Q + Q + EL S + + E + + ++
Sbjct: 1835 FD----DVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQM 1890
Query: 154 KSVSASEDLLEEIESELLSTEFAEHRVPNGM----NKGEHALVLFEKCVQDKYLQQEHII 209
+ +LLEE E + + ++ + M N E L E+ Q + +
Sbjct: 1891 DGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQ 1950
Query: 210 KKLIKENKKHQELFVDICSEKDNLREELKKRTET--EKQHMNTIKQLESRIEELNKEVKA 267
K L K+HQ+ + E D REE K+ + E +H +T+KQL + E N ++
Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQL---MREFNTQLAQ 2007
Query: 268 SRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRK 327
+L N Q++ E+ + ++ + + EK+ + + + +E LD R+
Sbjct: 2008 KEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDARE 2067
Query: 328 EKETLEKKLRDANKELEKNTNKIKQ-LSQEKG------RLHQLYETKEGETTRLIREIDK 380
E+ T K+RD +LE+ K +Q L QE+ + +L +T+ + T LI + K
Sbjct: 2068 EEMT--AKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL-QTQLAQKTTLISD-SK 2123
Query: 381 LKE 383
LKE
Sbjct: 2124 LKE 2126
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 125 bits (313), Expect = 2e-28
Identities = 202/964 (20%), Positives = 395/964 (40%), Gaps = 150/964 (15%)
Query: 7 IASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQ 66
+ S ++K + E E + + E+ + E E K+++L +K N+ +++A+
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEK-----NDLQLQVQAE 898
Query: 67 ENYIPDHGGGEDSCAKTDTG-----------SENSEQIANFPSGNFAKHISKTNETEQKV 115
+ + D D KT +E+ E+I + K + +E ++ +
Sbjct: 899 ADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958
Query: 116 TQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEF 175
+ + L + A E + + I+K+ + + L+E + L
Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL---TKEKKALQEAHQQTLDDLQ 1015
Query: 176 AEHRVPNGMNKGEHALVLFEKCVQDKY--LQQEHIIK--------KLIKENKKHQELFVD 225
AE N + K A + E+ V D L+QE I+ KL + K QE +D
Sbjct: 1016 AEEDKVNTLTK---AKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMD 1072
Query: 226 ICSEKDNLREELKK----------RTETEK----QHMNTIKQLESRIEELNKEVKASRDQ 271
I ++K L E+LKK + E E+ Q IK+L++RIEEL +E++A R
Sbjct: 1073 IENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAER-- 1130
Query: 272 LIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRK--EK 329
++ ++ ++++ +E+ +++ EEA A + + E E +R+ E+
Sbjct: 1131 ------ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 330 ETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHV 389
TL+ + A +K+ + + +L ++ L ++ + E E + + EID
Sbjct: 1185 ATLQHEATAATLR-KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID---------- 1233
Query: 390 IKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKS 449
++ S+ ET K K K+ +A E DQ+ + IKT +E ++
Sbjct: 1234 ------------DLASNMETVSKAKGNLEKMCRALE--DQLSE-----IKTKEEEQQRLI 1274
Query: 450 NELD---AKLRVTKGELEKQMQEKSDQLEM----HHAKIKELEDLKRTFKEGMDELRTLR 502
N+L A+L+ GE +Q+ EK + A +++E+LKR +E E++
Sbjct: 1275 NDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE---EIKAKS 1331
Query: 503 TKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLL----------------DKVKTADQL 546
L+ R D L + E KAE+Q + D ++ ++L
Sbjct: 1332 ALAHALQSSR-HDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEEL 1390
Query: 547 QEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSES 606
+E ++ Q +++ +E VE++N+ L+K + + +L++ ER + A L +
Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKK- 1449
Query: 607 NSLQSQFDKV------SCSESQLQSQCEQMKQTNINLESRLLK---EEELRKEEVQTLQA 657
Q FDK+ C E+ + + Q + +++ E +K EE L ++++TL+
Sbjct: 1450 ---QRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESL--DQLETLKR 1504
Query: 658 ELACRQTEVKALSTQVEE---LKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYD 714
E Q E+ L+ Q+ E EL +++ +L L++A L+ E
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILR 1564
Query: 715 KEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIER--IVRLQKAH 772
++ +S + + D+ N V++ A + R +RL+K
Sbjct: 1565 IQLELNQVKSEVDRKIAEKDEEIDQMKRN--HIRIVESMQSTLDAEIRSRNDAIRLKKKM 1622
Query: 773 ARKNEKIEFMEDHIKQLVEE----IRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRG 828
++E +H ++ E R I++ L + S E + RR
Sbjct: 1623 EGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRA 1682
Query: 829 GIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQ 888
++ + L +LE + + + E LL E +Q L T+ LI +
Sbjct: 1683 NLLQAEIEE--------LRATLEQTERSRKIAEQELL---DASERVQLLHTQNTSLINTK 1731
Query: 889 HELE 892
+LE
Sbjct: 1732 KKLE 1735
Score = 117 bits (294), Expect = 4e-26
Identities = 141/744 (18%), Positives = 334/744 (44%), Gaps = 110/744 (14%)
Query: 107 KTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEI 166
KT E EQ+ +++ +L + YS + D +S+ K + +EE+
Sbjct: 1264 KTKEEEQQ--RLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ--IEEL 1319
Query: 167 ESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENK-------KH 219
+ +L A+ + + + H L + +++ + + + + K N K+
Sbjct: 1320 KRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKY 1379
Query: 220 QELFVDICSEKDNLREELKKRTETEKQHMNTI-----------KQLESRIEELNKEVKAS 268
+ + E + +++L +R + ++H+ + ++L++ +E+L +V+ +
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERT 1439
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAM---VMKYVRGEKESLD- 324
A D +N ++ E Q+ E+ + + E +++E ++ + K +ESLD
Sbjct: 1440 NAACAALDKKQRN-FDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ 1498
Query: 325 ---LRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKL 381
L++E + L++++ D +++ + +I +L + K ++ Q ++ E + E +
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ----EKSELQAALEEAEAS 1554
Query: 382 KEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTY 441
E +++++ N++K+E+D K+ + EE DQ+++N ++++
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEVDR-------------KIAEKDEEIDQMKRNHIRIVESM 1601
Query: 442 QESEEIKSNELDAKLRVTKG--ELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELR 499
Q + LDA++R L+K+M+ +++E+ +L R E + R
Sbjct: 1602 QST-------LDAEIRSRNDAIRLKKKMEGDLNEMEI------QLNHANRMAAEALRNYR 1648
Query: 500 TLRTKVKCLE---DERLRTEDELSKYKEIINRQKAEIQNLLDKVK-TADQLQEQLQRGKQ 555
+ +K + D+ LR++++L + ++ R+ +Q +++++ T +Q + + +Q
Sbjct: 1649 NTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQ 1708
Query: 556 EIENLKEEVESLN----SLIND---LQKDIEGSRKRESELLLFTERLTSKNAQLQSESNS 608
E+ + E V+ L+ SLIN L+ DI + +++ K + +++
Sbjct: 1709 ELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAM 1768
Query: 609 LQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELR----KEEVQTLQAELACRQT 664
+ + K + + L+ + ++QT +L+ RL + E+L K+++Q L+A + R+
Sbjct: 1769 MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV--REL 1826
Query: 665 EVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRS 724
E + S Q + E V RKH +K+LT Q ++ R+ + +++ DK + + S
Sbjct: 1827 EGEVESEQKRNV--EAVKGLRKHERKVKELTYQTEEDRKNILRLQD-LVDKLQAKVKSYK 1883
Query: 725 SSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMED 784
+ AE++S N + + R+Q E+ + E
Sbjct: 1884 RQA------EEAEEQSNVN------------------LSKFRRIQHELEEAEERADIAES 1919
Query: 785 HIKQLVEEIRKKTKIIQSYILREE 808
+ +L R K++ + + I+ EE
Sbjct: 1920 QVNKL----RVKSREVHTKIISEE 1939
Score = 105 bits (262), Expect = 2e-22
Identities = 152/731 (20%), Positives = 308/731 (42%), Gaps = 76/731 (10%)
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
IK L+K + +E+ ++ E + +EEL K K+ + L +L +V+A
Sbjct: 840 IKPLLKSAETEKEM-ANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEA---MVMKYVRGEKESLDL 325
D L A+ QL K Q + + E A E+E + K + E E +L
Sbjct: 899 ADSL----ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 326 RKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDI 385
+K+ + LE L KE NK+K L++E L + E L + +D+
Sbjct: 955 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1014
Query: 386 NSHVIKVKW---AQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQ 442
+ KV A+ KL+ ++D + + ++ K+ L +AK + + K Q+ +
Sbjct: 1015 QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIE 1074
Query: 443 ESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLR 502
++ +LD KL+ + E+ + D+ + K++++L+ +E +E+ R
Sbjct: 1075 NDKQ----QLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAER 1130
Query: 503 TKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKE 562
E +R EL + E + ++ K + + + Q+ ++++E
Sbjct: 1131 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNK---KREAEFQKMRRDLEEATL 1187
Query: 563 EVESLNSLINDLQKD-IEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSES 621
+ E+ + + D + ++ L ++L + ++++ E + L S + VS ++
Sbjct: 1188 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKG 1247
Query: 622 QLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELV 681
L+ C ++ + S + +EE ++ + L A+ A QTE S Q++E KD LV
Sbjct: 1248 NLEKMCRALE----DQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDE-KDTLV 1302
Query: 682 TQ--RRKHASSIKDLTKQLQQARRKLDQ-----------VESGSYDKEVSSMGSRSSSSG 728
+Q R K A T+Q+++ +R+L++ ++S +D ++ R
Sbjct: 1303 SQLSRGKQA-----FTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDL----LREQYEE 1353
Query: 729 SLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQ 788
A++ + R+ S VA + + I+R L++A + ++++ E+H++
Sbjct: 1354 EQEAKAELQ-RAMSKANSEVA--QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Query: 789 L---VEEIRKKTKIIQSYI---------LREESGTLSSEASDFNKV---HLSRRGGIMAS 833
+ + K + +Q+ + L + +F+K+ + A
Sbjct: 1411 VNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1470
Query: 834 LYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLI-------K 886
L S L+ EL K++ E++L + TLK + L EI L K
Sbjct: 1471 LEASQKESRSLSTELF-----KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1525
Query: 887 HQHELEQRTKK 897
HELE+ K+
Sbjct: 1526 RIHELEKIKKQ 1536
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 124 bits (310), Expect = 5e-28
Identities = 179/804 (22%), Positives = 346/804 (43%), Gaps = 96/804 (11%)
Query: 150 ISKIKSVSAS-EDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHI 208
+ KI+ + DL E+++SE + AE + + + E E + QQE
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-- 1167
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
K+ QE+ V + + R + E ++H +++L ++E+ K KA+
Sbjct: 1168 -----LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF-KRAKAN 1221
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRME---QANKKCEEARQEKEAMVM----KYVRGEKE 321
D+ K +++ + ++A + QA ++ E +++ EA V K GE+
Sbjct: 1222 LDK-------NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 322 SLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLH-QLYETKEGETTRLIREIDK 380
+L + L+ ++ L + K +L+++ L QL +T+E L++E +
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE-----LLQEETR 1329
Query: 381 LKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKT 440
K ++++ + +++ +N L+ ++D E K L+ + L ++ +K QD T
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS---KKKLQDFAST 1386
Query: 441 YQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDEL-- 498
+ EE K +K+++ + Q E A +LE K ++ +D+L
Sbjct: 1387 VEALEEGKKR------------FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 499 --RTLRTKVKCLE------DERLRTEDELS-KYKEIINRQKAEIQNLLDKVKTADQLQEQ 549
R V LE D+ L E +S KY + +R +AE + K + + E+
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 550 LQRGKQEIEN----LKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSE 605
K+E+E LK E+E L S +D+ K++ K + L E + ++ +L+ E
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 606 SNSLQSQFDKVSCS--------ESQLQSQCEQMKQTNINLESRLLK-EEELRKEEVQTLQ 656
+ + ++ + E LQ++ EQ ++ L+ +L + E EL E Q
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 657 AELACRQTE--VKALSTQVEEL---KDELVTQRRKHASSIKDLTKQLQQARRKLDQV--- 708
A A ++ E +K L Q + ++E + Q RK + +KD ++L+ AR D++
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 709 ----ESGSYDKEVSSMGSRSSSSGSLNARSSAE---DRSPENTGSSVAVDNFPQVDKAML 761
E + E M + + + AR A+ + E SS++ N Q +K L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 762 IERIVRLQKAHARKNEKIEFMEDHIK---QLVEEIRKKTKIIQSYILREESGTLSSEASD 818
RI +L++ + +E M D ++ Q E++ + +S + ES E +
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 819 ---FNKVHLSRRGGIMASLYTSHPADNGLTLELSLEIN---RKLQAVLEDTLLKNITLKE 872
+K+H G + + ++ A +L ++ R+ QA + K+ LKE
Sbjct: 1795 KELRSKLH-EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 873 NLQTLGTEIERLIKHQHELEQRTK 896
L L E ER + Q++ EQ K
Sbjct: 1854 IL--LQVEDERKMAEQYK-EQAEK 1874
Score = 122 bits (306), Expect = 1e-27
Identities = 167/782 (21%), Positives = 339/782 (43%), Gaps = 97/782 (12%)
Query: 150 ISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGE--HALVLFEKCVQDKYLQQEH 207
+ + V+ E+ ++ E EL T+ + + N + + E H+ + EK + + LQ E
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 208 IIKKLIKENK-----KHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELN 262
+ +E + K QEL +I E + EE + R + + + Q +EE
Sbjct: 901 ELYAEAEEMRVRLAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 263 KEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEA---MVMKYVRGE 319
+E +A+R +L + VTA+ +++L E+ +Q NK +E + +E + E
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 320 KESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREID 379
+++ +L K K E + + L+K ++L + K +L + L +I
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 380 KLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIK 439
+LK + +++ A +L E+ K++E ++ +E+ D R
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER-------- 1131
Query: 440 TYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELR 499
+ E + +L +L K ELE + + Q E+ + +E+ LK+ E E R
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE---ETR 1188
Query: 500 TLRTKVKCLEDERLRTEDELSKYKEIINRQKAEI---QNLLDKVKTADQLQE--QLQRGK 554
+ +V+ + + + +EL++ E R KA + + L+K + AD E L + K
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK-ENADLAGELRVLGQAK 1247
Query: 555 QEIENLKEEVESLNSLINDLQ-KDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQF 613
QE+E+ K+++E + + +LQ K +G R R A+L + + LQ++
Sbjct: 1248 QEVEHKKKKLE---AQVQELQSKCSDGERAR---------------AELNDKVHKLQNEV 1289
Query: 614 DKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEV-QTLQAELACRQTEVKALSTQ 672
+ V+ ++ + + ++ + +L S+L +EL +EE Q L RQ E + S Q
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 673 VEELKDELVTQR--RKHASS----IKDLTKQLQQARRKLDQVESGS--YDKEVSSMGSRS 724
++L +E+ ++ +H S+ + D K+LQ ++ +E G + KE+ ++ +
Sbjct: 1350 -DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408
Query: 725 SSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMED 784
+KA +++ + + ++ + + D
Sbjct: 1409 E-------------------------------EKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 785 HIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGL 844
+ +QLV + KK + +L EE S A + ++ R +L + + L
Sbjct: 1438 NQRQLVSNLEKKQRKFDQ-LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496
Query: 845 TLELSLE-INRKLQAVLEDTLL------KNI-TLKENLQTLGTEIERLIKHQHELEQRTK 896
+ LE N+ L+A +ED + KN+ L+++ + L T++E + ELE +
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 897 KT 898
T
Sbjct: 1557 AT 1558
Score = 83.6 bits (205), Expect = 8e-16
Identities = 126/663 (19%), Positives = 280/663 (42%), Gaps = 62/663 (9%)
Query: 14 KNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDH 73
K+V +D+ L KL +KL L ++ Q ++ + +EA++N + H
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-DQLDEEMEAKQN-LERH 1365
Query: 74 GGG-----EDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFP 128
DS K + E + F K I + ++ +L +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKT--- 1421
Query: 129 ESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHR---VPNGMN 185
++ ++ + D D ++ +S ++ D L E + +S+++A+ R
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEARE 1480
Query: 186 KGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEK 245
K AL L + ++E L + NK + D+ S KD++ + + + ++++
Sbjct: 1481 KETKALSLARALEEALEAKEE-----LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 246 QHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEAR 305
++++++++EEL E++A+ D + +V + Q +++ R EQ EE R
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN----EEKR 1591
Query: 306 QEKEAMVMKYVRGEKESLDLRKEKE---TLEKKLRDANKELEKNTNKIKQLSQEKGRLHQ 362
++ + + +Y E E D RK++ +KKL K+LE + S KGR
Sbjct: 1592 RQLQRQLHEY---ETELEDERKQRALAAAAKKKLEGDLKDLELQAD-----SAIKGR--- 1640
Query: 363 LYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQ 422
E + +R++ +D + + +++++ A + KE + K K L Q
Sbjct: 1641 ------EEAIKQLRKLQAQMKDFQRELEDARASRDEIFA---TAKENEKKAKSLEADLMQ 1691
Query: 423 AKEE---ADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHA 479
+E+ A++ RK D+ K E S L+ K LE ++ + ++LE
Sbjct: 1692 LQEDLAAAERARKQA-DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1750
Query: 480 KIKELEDLKRTFKEGMD----ELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQN 535
++ + D R + + EL T R+ + E R + E + + + ++ + +++
Sbjct: 1751 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1810
Query: 536 LLDKVKTA-----DQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLL 590
A QL+EQ+++ +E + + ++ + + ++ +E RK +
Sbjct: 1811 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1870
Query: 591 FTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTN--INLESRLLKEEELR 648
E+ ++ QL+ + + + +++ + +LQ + ++ ++N + E LK + R
Sbjct: 1871 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Query: 649 KEE 651
E
Sbjct: 1931 GNE 1933
Score = 62.8 bits (151), Expect = 1e-09
Identities = 87/399 (21%), Positives = 173/399 (43%), Gaps = 70/399 (17%)
Query: 430 IRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKR 489
I++NC +K ++ L+VT+ E ++MQ K D+L+ K KE +
Sbjct: 819 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE--EEMQAKEDELQ----KTKERQQKAE 872
Query: 490 TFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQ 549
+ +++ + T+ K L E+L+ E EL Y E A++++ +
Sbjct: 873 NELKELEQKHSQLTEEKNLLQEQLQAETEL--YAE------------------AEEMRVR 912
Query: 550 LQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSL 609
L KQE+E + E+E+ D + ++ RK+ ++ +L E QL+ E +
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE------QLEEEEAAR 966
Query: 610 QS-QFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKA 668
Q Q +KV+ + + E + + N ++L KE +L +E + L LA + + K
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQN--NKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 669 LSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSG 728
L T+++ + ++++ + ++L++ +RKL+ ++ + ++++ + ++ +
Sbjct: 1025 L-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG-DASDFHEQIADLQAQIAELK 1082
Query: 729 SLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKN---EKIEFMEDH 785
A+ E L + RL A+KN +KI +E H
Sbjct: 1083 MQLAKKEEE-----------------------LQAALARLDDEIAQKNNALKKIRELEGH 1119
Query: 786 IKQLVEEI------RKKTKIIQSYILREESGTLSSEASD 818
I L E++ R K + Q L EE L +E D
Sbjct: 1120 ISDLQEDLDSERAARNKAE-KQKRDLGEELEALKTELED 1157
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 124 bits (310), Expect = 5e-28
Identities = 179/804 (22%), Positives = 346/804 (43%), Gaps = 96/804 (11%)
Query: 150 ISKIKSVSAS-EDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHI 208
+ KI+ + DL E+++SE + AE + + + E E + QQE
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-- 1174
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
K+ QE+ V + + R + E ++H +++L ++E+ K KA+
Sbjct: 1175 -----LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF-KRAKAN 1228
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRME---QANKKCEEARQEKEAMVM----KYVRGEKE 321
D+ K +++ + ++A + QA ++ E +++ EA V K GE+
Sbjct: 1229 LDK-------NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 322 SLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLH-QLYETKEGETTRLIREIDK 380
+L + L+ ++ L + K +L+++ L QL +T+E L++E +
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE-----LLQEETR 1336
Query: 381 LKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKT 440
K ++++ + +++ +N L+ ++D E K L+ + L ++ +K QD T
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS---KKKLQDFAST 1393
Query: 441 YQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDEL-- 498
+ EE K +K+++ + Q E A +LE K ++ +D+L
Sbjct: 1394 VEALEEGKKR------------FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 499 --RTLRTKVKCLE------DERLRTEDELS-KYKEIINRQKAEIQNLLDKVKTADQLQEQ 549
R V LE D+ L E +S KY + +R +AE + K + + E+
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 550 LQRGKQEIEN----LKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSE 605
K+E+E LK E+E L S +D+ K++ K + L E + ++ +L+ E
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 606 SNSLQSQFDKVSCS--------ESQLQSQCEQMKQTNINLESRLLK-EEELRKEEVQTLQ 656
+ + ++ + E LQ++ EQ ++ L+ +L + E EL E Q
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 657 AELACRQTE--VKALSTQVEEL---KDELVTQRRKHASSIKDLTKQLQQARRKLDQV--- 708
A A ++ E +K L Q + ++E + Q RK + +KD ++L+ AR D++
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 709 ----ESGSYDKEVSSMGSRSSSSGSLNARSSAE---DRSPENTGSSVAVDNFPQVDKAML 761
E + E M + + + AR A+ + E SS++ N Q +K L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 762 IERIVRLQKAHARKNEKIEFMEDHIK---QLVEEIRKKTKIIQSYILREESGTLSSEASD 818
RI +L++ + +E M D ++ Q E++ + +S + ES E +
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 819 ---FNKVHLSRRGGIMASLYTSHPADNGLTLELSLEIN---RKLQAVLEDTLLKNITLKE 872
+K+H G + + ++ A +L ++ R+ QA + K+ LKE
Sbjct: 1802 KELRSKLH-EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 873 NLQTLGTEIERLIKHQHELEQRTK 896
L L E ER + Q++ EQ K
Sbjct: 1861 IL--LQVEDERKMAEQYK-EQAEK 1881
Score = 122 bits (306), Expect = 1e-27
Identities = 167/782 (21%), Positives = 339/782 (43%), Gaps = 97/782 (12%)
Query: 150 ISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGE--HALVLFEKCVQDKYLQQEH 207
+ + V+ E+ ++ E EL T+ + + N + + E H+ + EK + + LQ E
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 208 IIKKLIKENK-----KHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELN 262
+ +E + K QEL +I E + EE + R + + + Q +EE
Sbjct: 908 ELYAEAEEMRVRLAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 263 KEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEA---MVMKYVRGE 319
+E +A+R +L + VTA+ +++L E+ +Q NK +E + +E + E
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 320 KESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREID 379
+++ +L K K E + + L+K ++L + K +L + L +I
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 380 KLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIK 439
+LK + +++ A +L E+ K++E ++ +E+ D R
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER-------- 1138
Query: 440 TYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELR 499
+ E + +L +L K ELE + + Q E+ + +E+ LK+ E E R
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE---ETR 1195
Query: 500 TLRTKVKCLEDERLRTEDELSKYKEIINRQKAEI---QNLLDKVKTADQLQE--QLQRGK 554
+ +V+ + + + +EL++ E R KA + + L+K + AD E L + K
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK-ENADLAGELRVLGQAK 1254
Query: 555 QEIENLKEEVESLNSLINDLQ-KDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQF 613
QE+E+ K+++E + + +LQ K +G R R A+L + + LQ++
Sbjct: 1255 QEVEHKKKKLE---AQVQELQSKCSDGERAR---------------AELNDKVHKLQNEV 1296
Query: 614 DKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEV-QTLQAELACRQTEVKALSTQ 672
+ V+ ++ + + ++ + +L S+L +EL +EE Q L RQ E + S Q
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 673 VEELKDELVTQR--RKHASS----IKDLTKQLQQARRKLDQVESGS--YDKEVSSMGSRS 724
++L +E+ ++ +H S+ + D K+LQ ++ +E G + KE+ ++ +
Sbjct: 1357 -DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415
Query: 725 SSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMED 784
+KA +++ + + ++ + + D
Sbjct: 1416 E-------------------------------EKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 785 HIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGL 844
+ +QLV + KK + +L EE S A + ++ R +L + + L
Sbjct: 1445 NQRQLVSNLEKKQRKFDQ-LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503
Query: 845 TLELSLE-INRKLQAVLEDTLL------KNI-TLKENLQTLGTEIERLIKHQHELEQRTK 896
+ LE N+ L+A +ED + KN+ L+++ + L T++E + ELE +
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 897 KT 898
T
Sbjct: 1564 AT 1565
Score = 83.6 bits (205), Expect = 8e-16
Identities = 126/663 (19%), Positives = 280/663 (42%), Gaps = 62/663 (9%)
Query: 14 KNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDH 73
K+V +D+ L KL +KL L ++ Q ++ + +EA++N + H
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-DQLDEEMEAKQN-LERH 1372
Query: 74 GGG-----EDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFP 128
DS K + E + F K I + ++ +L +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKT--- 1428
Query: 129 ESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHR---VPNGMN 185
++ ++ + D D ++ +S ++ D L E + +S+++A+ R
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEARE 1487
Query: 186 KGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEK 245
K AL L + ++E L + NK + D+ S KD++ + + + ++++
Sbjct: 1488 KETKALSLARALEEALEAKEE-----LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 246 QHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEAR 305
++++++++EEL E++A+ D + +V + Q +++ R EQ EE R
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN----EEKR 1598
Query: 306 QEKEAMVMKYVRGEKESLDLRKEKE---TLEKKLRDANKELEKNTNKIKQLSQEKGRLHQ 362
++ + + +Y E E D RK++ +KKL K+LE + S KGR
Sbjct: 1599 RQLQRQLHEY---ETELEDERKQRALAAAAKKKLEGDLKDLELQAD-----SAIKGR--- 1647
Query: 363 LYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQ 422
E + +R++ +D + + +++++ A + KE + K K L Q
Sbjct: 1648 ------EEAIKQLRKLQAQMKDFQRELEDARASRDEIFA---TAKENEKKAKSLEADLMQ 1698
Query: 423 AKEE---ADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHA 479
+E+ A++ RK D+ K E S L+ K LE ++ + ++LE
Sbjct: 1699 LQEDLAAAERARKQA-DLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG 1757
Query: 480 KIKELEDLKRTFKEGMD----ELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQN 535
++ + D R + + EL T R+ + E R + E + + + ++ + +++
Sbjct: 1758 NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS 1817
Query: 536 LLDKVKTA-----DQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLL 590
A QL+EQ+++ +E + + ++ + + ++ +E RK +
Sbjct: 1818 KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKE 1877
Query: 591 FTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTN--INLESRLLKEEELR 648
E+ ++ QL+ + + + +++ + +LQ + ++ ++N + E LK + R
Sbjct: 1878 QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Query: 649 KEE 651
E
Sbjct: 1938 GNE 1940
Score = 62.8 bits (151), Expect = 1e-09
Identities = 87/399 (21%), Positives = 173/399 (43%), Gaps = 70/399 (17%)
Query: 430 IRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKR 489
I++NC +K ++ L+VT+ E ++MQ K D+L+ K KE +
Sbjct: 826 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE--EEMQAKEDELQ----KTKERQQKAE 879
Query: 490 TFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQ 549
+ +++ + T+ K L E+L+ E EL Y E A++++ +
Sbjct: 880 NELKELEQKHSQLTEEKNLLQEQLQAETEL--YAE------------------AEEMRVR 919
Query: 550 LQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSL 609
L KQE+E + E+E+ D + ++ RK+ ++ +L E QL+ E +
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE------QLEEEEAAR 973
Query: 610 QS-QFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKA 668
Q Q +KV+ + + E + + N ++L KE +L +E + L LA + + K
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQN--NKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 669 LSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSG 728
L T+++ + ++++ + ++L++ +RKL+ ++ + ++++ + ++ +
Sbjct: 1032 L-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG-DASDFHEQIADLQAQIAELK 1089
Query: 729 SLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKN---EKIEFMEDH 785
A+ E L + RL A+KN +KI +E H
Sbjct: 1090 MQLAKKEEE-----------------------LQAALARLDDEIAQKNNALKKIRELEGH 1126
Query: 786 IKQLVEEI------RKKTKIIQSYILREESGTLSSEASD 818
I L E++ R K + Q L EE L +E D
Sbjct: 1127 ISDLQEDLDSERAARNKAE-KQKRDLGEELEALKTELED 1164
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 124 bits (310), Expect = 5e-28
Identities = 179/804 (22%), Positives = 346/804 (43%), Gaps = 96/804 (11%)
Query: 150 ISKIKSVSAS-EDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHI 208
+ KI+ + DL E+++SE + AE + + + E E + QQE
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-- 1174
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
K+ QE+ V + + R + E ++H +++L ++E+ K KA+
Sbjct: 1175 -----LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF-KRAKAN 1228
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRME---QANKKCEEARQEKEAMVM----KYVRGEKE 321
D+ K +++ + ++A + QA ++ E +++ EA V K GE+
Sbjct: 1229 LDK-------NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 322 SLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLH-QLYETKEGETTRLIREIDK 380
+L + L+ ++ L + K +L+++ L QL +T+E L++E +
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE-----LLQEETR 1336
Query: 381 LKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKT 440
K ++++ + +++ +N L+ ++D E K L+ + L ++ +K QD T
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS---KKKLQDFAST 1393
Query: 441 YQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDEL-- 498
+ EE K +K+++ + Q E A +LE K ++ +D+L
Sbjct: 1394 VEALEEGKKR------------FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 499 --RTLRTKVKCLE------DERLRTEDELS-KYKEIINRQKAEIQNLLDKVKTADQLQEQ 549
R V LE D+ L E +S KY + +R +AE + K + + E+
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 550 LQRGKQEIEN----LKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSE 605
K+E+E LK E+E L S +D+ K++ K + L E + ++ +L+ E
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 606 SNSLQSQFDKVSCS--------ESQLQSQCEQMKQTNINLESRLLK-EEELRKEEVQTLQ 656
+ + ++ + E LQ++ EQ ++ L+ +L + E EL E Q
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 657 AELACRQTE--VKALSTQVEEL---KDELVTQRRKHASSIKDLTKQLQQARRKLDQV--- 708
A A ++ E +K L Q + ++E + Q RK + +KD ++L+ AR D++
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 709 ----ESGSYDKEVSSMGSRSSSSGSLNARSSAE---DRSPENTGSSVAVDNFPQVDKAML 761
E + E M + + + AR A+ + E SS++ N Q +K L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 762 IERIVRLQKAHARKNEKIEFMEDHIK---QLVEEIRKKTKIIQSYILREESGTLSSEASD 818
RI +L++ + +E M D ++ Q E++ + +S + ES E +
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 819 ---FNKVHLSRRGGIMASLYTSHPADNGLTLELSLEIN---RKLQAVLEDTLLKNITLKE 872
+K+H G + + ++ A +L ++ R+ QA + K+ LKE
Sbjct: 1802 KELRSKLH-EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 873 NLQTLGTEIERLIKHQHELEQRTK 896
L L E ER + Q++ EQ K
Sbjct: 1861 IL--LQVEDERKMAEQYK-EQAEK 1881
Score = 122 bits (306), Expect = 1e-27
Identities = 167/782 (21%), Positives = 339/782 (43%), Gaps = 97/782 (12%)
Query: 150 ISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGE--HALVLFEKCVQDKYLQQEH 207
+ + V+ E+ ++ E EL T+ + + N + + E H+ + EK + + LQ E
Sbjct: 848 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 907
Query: 208 IIKKLIKENK-----KHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELN 262
+ +E + K QEL +I E + EE + R + + + Q +EE
Sbjct: 908 ELYAEAEEMRVRLAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 966
Query: 263 KEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEA---MVMKYVRGE 319
+E +A+R +L + VTA+ +++L E+ +Q NK +E + +E + E
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 320 KESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREID 379
+++ +L K K E + + L+K ++L + K +L + L +I
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 380 KLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIK 439
+LK + +++ A +L E+ K++E ++ +E+ D R
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER-------- 1138
Query: 440 TYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELR 499
+ E + +L +L K ELE + + Q E+ + +E+ LK+ E E R
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE---ETR 1195
Query: 500 TLRTKVKCLEDERLRTEDELSKYKEIINRQKAEI---QNLLDKVKTADQLQE--QLQRGK 554
+ +V+ + + + +EL++ E R KA + + L+K + AD E L + K
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK-ENADLAGELRVLGQAK 1254
Query: 555 QEIENLKEEVESLNSLINDLQ-KDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQF 613
QE+E+ K+++E + + +LQ K +G R R A+L + + LQ++
Sbjct: 1255 QEVEHKKKKLE---AQVQELQSKCSDGERAR---------------AELNDKVHKLQNEV 1296
Query: 614 DKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEV-QTLQAELACRQTEVKALSTQ 672
+ V+ ++ + + ++ + +L S+L +EL +EE Q L RQ E + S Q
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 673 VEELKDELVTQR--RKHASS----IKDLTKQLQQARRKLDQVESGS--YDKEVSSMGSRS 724
++L +E+ ++ +H S+ + D K+LQ ++ +E G + KE+ ++ +
Sbjct: 1357 -DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1415
Query: 725 SSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMED 784
+KA +++ + + ++ + + D
Sbjct: 1416 E-------------------------------EKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 785 HIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGL 844
+ +QLV + KK + +L EE S A + ++ R +L + + L
Sbjct: 1445 NQRQLVSNLEKKQRKFDQ-LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1503
Query: 845 TLELSLE-INRKLQAVLEDTLL------KNI-TLKENLQTLGTEIERLIKHQHELEQRTK 896
+ LE N+ L+A +ED + KN+ L+++ + L T++E + ELE +
Sbjct: 1504 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Query: 897 KT 898
T
Sbjct: 1564 AT 1565
Score = 87.4 bits (215), Expect = 5e-17
Identities = 126/651 (19%), Positives = 279/651 (42%), Gaps = 83/651 (12%)
Query: 14 KNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDH 73
K+V +D+ L KL +KL L ++ Q ++ + +EA++N + H
Sbjct: 1315 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-DQLDEEMEAKQN-LERH 1372
Query: 74 GGG-----EDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFP 128
DS K + E + F K I + ++ +L +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKT--- 1428
Query: 129 ESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHR---VPNGMN 185
++ ++ + D D ++ +S ++ D L E + +S+++A+ R
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEARE 1487
Query: 186 KGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEK 245
K AL L + ++E L + NK + D+ S KD++ + + + ++++
Sbjct: 1488 KETKALSLARALEEALEAKEE-----LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1542
Query: 246 QHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKK----- 300
++++++++EEL E++A+ D + +V + Q +++ R EQ +K
Sbjct: 1543 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 301 ---------CEEARQEKE--AMVMKYVRGEKESLDLR-----KEKETLEKKLRDANKELE 344
E+ R+++ A K + G+ + L+L+ K +E K+LR +++
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 345 KNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQ-------N 397
+++ + + + E + L ++ +L+ED+ + K A
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722
Query: 398 KLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMI----KTYQESEEIKSNELD 453
+L + + +D+ + ++ Q +EE ++ + N + M K Q++E++ SNEL
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL-SNEL- 1780
Query: 454 AKLRVTKGELEKQMQEKSDQLEMHHAKIKELED-LKRTFKEGMDELRTLRTKVKCLEDER 512
A R T + E Q+ Q + +K+ E+E +K FK + L K+ LE++
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS---TIAALEAKIAQLEEQV 1837
Query: 513 LRTEDELSKYKEIINRQKAEIQNLL----DKVKTADQLQEQLQRG-------KQEIENLK 561
+ E + + ++ +++ +L D+ K A+Q +EQ ++G K+++E +
Sbjct: 1838 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1897
Query: 562 EEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQ 612
EE + +N+ LQ+++ + T N + E N+L+S+
Sbjct: 1898 EESQRINANRRKLQREL--------------DEATESNEAMGREVNALKSK 1934
Score = 62.8 bits (151), Expect = 1e-09
Identities = 87/399 (21%), Positives = 173/399 (43%), Gaps = 70/399 (17%)
Query: 430 IRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKR 489
I++NC +K ++ L+VT+ E ++MQ K D+L+ K KE +
Sbjct: 826 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE--EEMQAKEDELQ----KTKERQQKAE 879
Query: 490 TFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQ 549
+ +++ + T+ K L E+L+ E EL Y E A++++ +
Sbjct: 880 NELKELEQKHSQLTEEKNLLQEQLQAETEL--YAE------------------AEEMRVR 919
Query: 550 LQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSL 609
L KQE+E + E+E+ D + ++ RK+ ++ +L E QL+ E +
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE------QLEEEEAAR 973
Query: 610 QS-QFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKA 668
Q Q +KV+ + + E + + N ++L KE +L +E + L LA + + K
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQN--NKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 669 LSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSG 728
L T+++ + ++++ + ++L++ +RKL+ ++ + ++++ + ++ +
Sbjct: 1032 L-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG-DASDFHEQIADLQAQIAELK 1089
Query: 729 SLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKN---EKIEFMEDH 785
A+ E L + RL A+KN +KI +E H
Sbjct: 1090 MQLAKKEEE-----------------------LQAALARLDDEIAQKNNALKKIRELEGH 1126
Query: 786 IKQLVEEI------RKKTKIIQSYILREESGTLSSEASD 818
I L E++ R K + Q L EE L +E D
Sbjct: 1127 ISDLQEDLDSERAARNKAE-KQKRDLGEELEALKTELED 1164
Score = 55.8 bits (133), Expect = 2e-07
Identities = 46/237 (19%), Positives = 108/237 (45%), Gaps = 18/237 (7%)
Query: 164 EEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELF 223
EE+ EL S+ + + + + E + E+ ++++ E + ++ K ++ ++L
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1777
Query: 224 VDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAV 283
++ +E+ ++ R + E+Q+ K+L S++ E+ VK+ K+ +
Sbjct: 1778 NELATERSTAQKNESARQQLERQN----KELRSKLHEMEGAVKSK----------FKSTI 1823
Query: 284 QQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKEL 343
L ++AQ EQ E+ +EK+A + +K+ ++ + E K ++
Sbjct: 1824 AALEAKIAQLEEQV----EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879
Query: 344 EKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLK 400
EK ++KQL ++ + + +L RE+D+ E + +V ++KL+
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 124 bits (310), Expect = 5e-28
Identities = 179/804 (22%), Positives = 346/804 (43%), Gaps = 96/804 (11%)
Query: 150 ISKIKSVSAS-EDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHI 208
+ KI+ + DL E+++SE + AE + + + E E + QQE
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE-- 1167
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
K+ QE+ V + + R + E ++H +++L ++E+ K KA+
Sbjct: 1168 -----LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF-KRAKAN 1221
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRME---QANKKCEEARQEKEAMVM----KYVRGEKE 321
D+ K +++ + ++A + QA ++ E +++ EA V K GE+
Sbjct: 1222 LDK-------NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 322 SLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLH-QLYETKEGETTRLIREIDK 380
+L + L+ ++ L + K +L+++ L QL +T+E L++E +
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQE-----LLQEETR 1329
Query: 381 LKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKT 440
K ++++ + +++ +N L+ ++D E K L+ + L ++ +K QD T
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS---KKKLQDFAST 1386
Query: 441 YQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDEL-- 498
+ EE K +K+++ + Q E A +LE K ++ +D+L
Sbjct: 1387 VEALEEGKKR------------FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 499 --RTLRTKVKCLE------DERLRTEDELS-KYKEIINRQKAEIQNLLDKVKTADQLQEQ 549
R V LE D+ L E +S KY + +R +AE + K + + E+
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 550 LQRGKQEIEN----LKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSE 605
K+E+E LK E+E L S +D+ K++ K + L E + ++ +L+ E
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 606 SNSLQSQFDKVSCS--------ESQLQSQCEQMKQTNINLESRLLK-EEELRKEEVQTLQ 656
+ + ++ + E LQ++ EQ ++ L+ +L + E EL E Q
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 657 AELACRQTE--VKALSTQVEEL---KDELVTQRRKHASSIKDLTKQLQQARRKLDQV--- 708
A A ++ E +K L Q + ++E + Q RK + +KD ++L+ AR D++
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 709 ----ESGSYDKEVSSMGSRSSSSGSLNARSSAE---DRSPENTGSSVAVDNFPQVDKAML 761
E + E M + + + AR A+ + E SS++ N Q +K L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 762 IERIVRLQKAHARKNEKIEFMEDHIK---QLVEEIRKKTKIIQSYILREESGTLSSEASD 818
RI +L++ + +E M D ++ Q E++ + +S + ES E +
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 819 ---FNKVHLSRRGGIMASLYTSHPADNGLTLELSLEIN---RKLQAVLEDTLLKNITLKE 872
+K+H G + + ++ A +L ++ R+ QA + K+ LKE
Sbjct: 1795 KELRSKLH-EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 873 NLQTLGTEIERLIKHQHELEQRTK 896
L L E ER + Q++ EQ K
Sbjct: 1854 IL--LQVEDERKMAEQYK-EQAEK 1874
Score = 122 bits (306), Expect = 1e-27
Identities = 167/782 (21%), Positives = 339/782 (43%), Gaps = 97/782 (12%)
Query: 150 ISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGE--HALVLFEKCVQDKYLQQEH 207
+ + V+ E+ ++ E EL T+ + + N + + E H+ + EK + + LQ E
Sbjct: 841 VKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAET 900
Query: 208 IIKKLIKENK-----KHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELN 262
+ +E + K QEL +I E + EE + R + + + Q +EE
Sbjct: 901 ELYAEAEEMRVRLAAKKQEL-EEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL 959
Query: 263 KEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEA---MVMKYVRGE 319
+E +A+R +L + VTA+ +++L E+ +Q NK +E + +E + E
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 320 KESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREID 379
+++ +L K K E + + L+K ++L + K +L + L +I
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 380 KLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIK 439
+LK + +++ A +L E+ K++E ++ +E+ D R
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER-------- 1131
Query: 440 TYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELR 499
+ E + +L +L K ELE + + Q E+ + +E+ LK+ E E R
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE---ETR 1188
Query: 500 TLRTKVKCLEDERLRTEDELSKYKEIINRQKAEI---QNLLDKVKTADQLQE--QLQRGK 554
+ +V+ + + + +EL++ E R KA + + L+K + AD E L + K
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK-ENADLAGELRVLGQAK 1247
Query: 555 QEIENLKEEVESLNSLINDLQ-KDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQF 613
QE+E+ K+++E + + +LQ K +G R R A+L + + LQ++
Sbjct: 1248 QEVEHKKKKLE---AQVQELQSKCSDGERAR---------------AELNDKVHKLQNEV 1289
Query: 614 DKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEV-QTLQAELACRQTEVKALSTQ 672
+ V+ ++ + + ++ + +L S+L +EL +EE Q L RQ E + S Q
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 673 VEELKDELVTQR--RKHASS----IKDLTKQLQQARRKLDQVESGS--YDKEVSSMGSRS 724
++L +E+ ++ +H S+ + D K+LQ ++ +E G + KE+ ++ +
Sbjct: 1350 -DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY 1408
Query: 725 SSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMED 784
+KA +++ + + ++ + + D
Sbjct: 1409 E-------------------------------EKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 785 HIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGL 844
+ +QLV + KK + +L EE S A + ++ R +L + + L
Sbjct: 1438 NQRQLVSNLEKKQRKFDQ-LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEAL 1496
Query: 845 TLELSLE-INRKLQAVLEDTLL------KNI-TLKENLQTLGTEIERLIKHQHELEQRTK 896
+ LE N+ L+A +ED + KN+ L+++ + L T++E + ELE +
Sbjct: 1497 EAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Query: 897 KT 898
T
Sbjct: 1557 AT 1558
Score = 87.4 bits (215), Expect = 5e-17
Identities = 126/651 (19%), Positives = 279/651 (42%), Gaps = 83/651 (12%)
Query: 14 KNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDH 73
K+V +D+ L KL +KL L ++ Q ++ + +EA++N + H
Sbjct: 1308 KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-DQLDEEMEAKQN-LERH 1365
Query: 74 GGG-----EDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFP 128
DS K + E + F K I + ++ +L +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKT--- 1421
Query: 129 ESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHR---VPNGMN 185
++ ++ + D D ++ +S ++ D L E + +S+++A+ R
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEARE 1480
Query: 186 KGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEK 245
K AL L + ++E L + NK + D+ S KD++ + + + ++++
Sbjct: 1481 KETKALSLARALEEALEAKEE-----LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKR 1535
Query: 246 QHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKK----- 300
++++++++EEL E++A+ D + +V + Q +++ R EQ +K
Sbjct: 1536 ALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 301 ---------CEEARQEKE--AMVMKYVRGEKESLDLR-----KEKETLEKKLRDANKELE 344
E+ R+++ A K + G+ + L+L+ K +E K+LR +++
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 345 KNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQ-------N 397
+++ + + + E + L ++ +L+ED+ + K A
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715
Query: 398 KLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMI----KTYQESEEIKSNELD 453
+L + + +D+ + ++ Q +EE ++ + N + M K Q++E++ SNEL
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL-SNEL- 1773
Query: 454 AKLRVTKGELEKQMQEKSDQLEMHHAKIKELED-LKRTFKEGMDELRTLRTKVKCLEDER 512
A R T + E Q+ Q + +K+ E+E +K FK + L K+ LE++
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS---TIAALEAKIAQLEEQV 1830
Query: 513 LRTEDELSKYKEIINRQKAEIQNLL----DKVKTADQLQEQLQRG-------KQEIENLK 561
+ E + + ++ +++ +L D+ K A+Q +EQ ++G K+++E +
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAE 1890
Query: 562 EEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQ 612
EE + +N+ LQ+++ + T N + E N+L+S+
Sbjct: 1891 EESQRINANRRKLQREL--------------DEATESNEAMGREVNALKSK 1927
Score = 62.8 bits (151), Expect = 1e-09
Identities = 87/399 (21%), Positives = 173/399 (43%), Gaps = 70/399 (17%)
Query: 430 IRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKR 489
I++NC +K ++ L+VT+ E ++MQ K D+L+ K KE +
Sbjct: 819 IQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQE--EEMQAKEDELQ----KTKERQQKAE 872
Query: 490 TFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQ 549
+ +++ + T+ K L E+L+ E EL Y E A++++ +
Sbjct: 873 NELKELEQKHSQLTEEKNLLQEQLQAETEL--YAE------------------AEEMRVR 912
Query: 550 LQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSL 609
L KQE+E + E+E+ D + ++ RK+ ++ +L E QL+ E +
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE------QLEEEEAAR 966
Query: 610 QS-QFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKA 668
Q Q +KV+ + + E + + N ++L KE +L +E + L LA + + K
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQN--NKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 669 LSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSG 728
L T+++ + ++++ + ++L++ +RKL+ ++ + ++++ + ++ +
Sbjct: 1025 L-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG-DASDFHEQIADLQAQIAELK 1082
Query: 729 SLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKN---EKIEFMEDH 785
A+ E L + RL A+KN +KI +E H
Sbjct: 1083 MQLAKKEEE-----------------------LQAALARLDDEIAQKNNALKKIRELEGH 1119
Query: 786 IKQLVEEI------RKKTKIIQSYILREESGTLSSEASD 818
I L E++ R K + Q L EE L +E D
Sbjct: 1120 ISDLQEDLDSERAARNKAE-KQKRDLGEELEALKTELED 1157
Score = 55.8 bits (133), Expect = 2e-07
Identities = 46/237 (19%), Positives = 108/237 (45%), Gaps = 18/237 (7%)
Query: 164 EEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELF 223
EE+ EL S+ + + + + E + E+ ++++ E + ++ K ++ ++L
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLS 1770
Query: 224 VDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAV 283
++ +E+ ++ R + E+Q+ K+L S++ E+ VK+ K+ +
Sbjct: 1771 NELATERSTAQKNESARQQLERQN----KELRSKLHEMEGAVKSK----------FKSTI 1816
Query: 284 QQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKEL 343
L ++AQ EQ E+ +EK+A + +K+ ++ + E K ++
Sbjct: 1817 AALEAKIAQLEEQV----EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872
Query: 344 EKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLK 400
EK ++KQL ++ + + +L RE+D+ E + +V ++KL+
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 121 bits (304), Expect = 3e-27
Identities = 154/727 (21%), Positives = 313/727 (43%), Gaps = 115/727 (15%)
Query: 161 DLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQE----------HIIK 210
+L E+ ESE S AE + + + E E + QQE + K
Sbjct: 1122 ELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKK 1181
Query: 211 KLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRD 270
L +E K H+ D+ EEL ++ E K+ +++ + +E NKE+ +
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC--E 1239
Query: 271 QLIAQDVTAKNA---------VQQLHKEMAQ----RMEQANKKCEEARQEKEAMVMKYVR 317
+ Q V A++ VQ+LH ++++ R+E A +K + + E + +
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA-EKASKLQNELDNVSTLLEE 1298
Query: 318 GEKESLDLRKEKETLEKKLRDANKELEKNT-------NKIKQLSQEKGRLHQLYETKEGE 370
EK+ + K+ +LE +L+D + L++ T ++I+QL +EK L + E +E
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE-- 1356
Query: 371 TTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQI 430
+ ++++ V+ ++ K ++D T + L+E KL ++A+ +
Sbjct: 1357 ---------EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLL---KDAEAL 1404
Query: 431 RKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRT 490
+ ++ Y KL TK L++++ + + L+ LE ++
Sbjct: 1405 SQRLEEKALAYD------------KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKK 1452
Query: 491 FKEGMDELRTLRTKVKCLEDERLRTEDELS-KYKEIINRQKAEIQNLLDKVKTADQLQEQ 549
F D+ L E +S +Y E +R +AE + K + + E+
Sbjct: 1453 F------------------DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEE 1494
Query: 550 LQRGKQEIE----NLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSE 605
K+E E L+ ++E L S +D+ K++ K + L E + ++ +L+ E
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554
Query: 606 SNSLQSQFDKVSCSESQLQSQCEQMKQT----NINLESRLLK-----EEELRKEEVQTLQ 656
+ + ++ + +++Q E+ QT N + L+K E EL E Q
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRAL 1614
Query: 657 AELACRQTEV--KALSTQVE---ELKDELVTQRRKHASSIKDLTKQLQQARRKLDQV--E 709
A + ++ E+ K L Q+E + +DE++ Q RK + +KD ++L++AR D++ +
Sbjct: 1615 AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ 1674
Query: 710 SGSYDKEVSSMGSR---------SSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAM 760
S +K++ S+ + SS +A ++ + E T S+ K+
Sbjct: 1675 SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASG--------KSA 1726
Query: 761 LIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFN 820
L++ RL+ A+ E++E + +++ L + RK T + + + +++ SD
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA 1786
Query: 821 KVHLSRR 827
+ L R+
Sbjct: 1787 RQQLERQ 1793
Score = 113 bits (282), Expect = 9e-25
Identities = 146/749 (19%), Positives = 325/749 (43%), Gaps = 106/749 (14%)
Query: 209 IKKLIKENKKHQELFV---DICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEV 265
+K L++ ++ +EL ++ K+ + + E E++H +++ E+L E
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900
Query: 266 K--ASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESL 323
+ A +++ A+ K ++++ ++ R+E+ ++ + + EK+ M +++ +E L
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM-QAHIQDLEEQL 959
Query: 324 D--------LRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLI 375
D L+ EK T E K++ +E+ ++ + +EK +L E + E + +
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK----KLMEDRIAECSSQL 1015
Query: 376 REIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQ 435
E +E+ ++ K++ NK + + +E K ++T +L +AK + D + Q
Sbjct: 1016 AE----EEEKAKNLAKIR---NKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 436 DMIKTYQ-ESEEIK----SNELDAKLRVTKG---------------ELEKQMQEKSDQLE 475
D I Q + +E+K E + + + +G EL+ Q+ E + E
Sbjct: 1069 DQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128
Query: 476 MHHAKIKELEDLKRTFKEGMDELRT--------------LRTK--------VKCLEDERL 513
A + E KR E ++ L+T LRTK K LE+E
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEE-- 1186
Query: 514 RTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLIND 573
T++ ++ +++ R ++ L ++++ A + + L++ KQ +E +E+ ++
Sbjct: 1187 -TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1245
Query: 574 LQKDIEGSRKR----ESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQ 629
++ + E RK+ EL +L +++ LQ++ D VS + + + +
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 630 MKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHAS 689
+ +LES+L +EL +EE + ++ + + Q+EE K+ L Q+ +
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETR--------QKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Query: 690 SIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVA 749
+ K+L KQ+ + +L + D ++ ++ S + L + A + E
Sbjct: 1358 ARKNLEKQVLALQSQLADTKK-KVDDDLGTIESLEEAKKKLLKDAEALSQRLE------- 1409
Query: 750 VDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREES 809
+KA+ +++ + + ++ + + DH +Q+ + KK K +L EE
Sbjct: 1410 -------EKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ-LLAEEK 1461
Query: 810 GTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLE-INRKLQAVLEDTLLKNI 868
+ A + ++ R +L + + L + E N++L+A +ED
Sbjct: 1462 SISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED------ 1515
Query: 869 TLKENLQTLGTEIERLIKHQHELEQRTKK 897
L + +G + L K + LEQ+ ++
Sbjct: 1516 -LMSSKDDVGKNVHELEKSKRALEQQVEE 1543
Score = 109 bits (273), Expect = 1e-23
Identities = 168/812 (20%), Positives = 334/812 (41%), Gaps = 86/812 (10%)
Query: 110 ETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESE 169
E K Q + EL+ + E+ N + + + + +A E+L E++E
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQD-----------MRQRHATALEELSEQLEQ- 1214
Query: 170 LLSTEFAEHRVPN--GMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDIC 227
+ F + N G+ L K +Q + EH KKL + + QEL +
Sbjct: 1215 --AKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL---DAQVQELHAKV- 1268
Query: 228 SEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLH 287
SE D LR EL ++ + ++ + L E+ K +K ++D + + Q+L
Sbjct: 1269 SEGDRLRVELAEKASKLQNELDNVSTLLEEAEK--KGIKFAKDAASLE--SQLQDTQELL 1324
Query: 288 KEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNT 347
+E ++ + + + +EK ++ + E+ +L K+ L+ +L D K+++ +
Sbjct: 1325 QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDL 1384
Query: 348 NKIKQLSQEKGRLHQ--------------LYETKEGETTRLIREIDKLKEDINSHVIKVK 393
I+ L + K +L + Y+ E RL +E+D L D++
Sbjct: 1385 GTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVAS 1444
Query: 394 WAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELD 453
+ K K E K + +A+ EA + + + +E+ E K E +
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE-EFE 1503
Query: 454 AKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRT----LRTKVKCLE 509
+ + + ++E M K D + H ELE KR ++ ++E+RT L +++ E
Sbjct: 1504 RQNKQLRADMEDLMSSKDDVGKNVH----ELEKSKRALEQQVEEMRTQLEELEDELQATE 1559
Query: 510 DERLRTEDELSKYKEIINR-------QKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKE 562
D +LR E + K R Q E + LL +K +L+ +L+ +++
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL--IKQVRELEAELEDERKQRALAVA 1617
Query: 563 EVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQ 622
+ + + DL+ IE + K E++ + +LQ++ Q + ++ S +
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVI-------KQLRKLQAQMKDYQRELEEARASRDE 1670
Query: 623 LQSQCEQMKQTNINLESRLLK-EEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELV 681
+ +Q ++ ++ +LE+ +L+ +EEL E AE + E+ T K L+
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQ--ERDELADEITNSASGKSALL 1728
Query: 682 TQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSP 741
++R+ + I L ++L++ + ++ + D+ + + + L A SA +S
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQSNMELLN----DRFRKTTLQVDTLNAELAAERSAAQKS- 1783
Query: 742 ENTGSSVAVDNFPQVDKAMLIERIVRLQ-KAHARKNE-KIEFMEDHIKQLVEE------- 792
+N + N K +E V+ + KA E KI +E+ ++Q +E
Sbjct: 1784 DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKL 1843
Query: 793 IRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTS-HPADNGLTLELSLE 851
+R+ K ++ ++ E +D K + + M L A+ T +
Sbjct: 1844 VRRTEKKLKEIFMQVED---ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1900
Query: 852 INRKLQAVLEDTLLKNITLKENLQTLGTEIER 883
RKLQ L+D N L + TL + R
Sbjct: 1901 --RKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 100 bits (250), Expect = 5e-21
Identities = 127/579 (21%), Positives = 259/579 (44%), Gaps = 71/579 (12%)
Query: 206 EHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTI----KQLESRIEEL 261
E KKL+K+ + + + D L E+ K R + E + +Q+ S +E+
Sbjct: 1391 EEAKKKLLKDAEALSQRLEEKALAYDKL-EKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449
Query: 262 NKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKE 321
K+ DQL+A++ K ++ R + + E +EKE + R +E
Sbjct: 1450 QKKF----DQLLAEE-----------KSISARYAEERDRAEAEAREKETKALSLARALEE 1494
Query: 322 SLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKL 381
+L+ ++E E K+LR ++L + + + + E + + E + E + E++
Sbjct: 1495 ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554
Query: 382 KEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKL-----TQAKEEADQIRKNCQD 436
+ ++++ +KA+ + +T+D+ E +L + + E + RK +
Sbjct: 1555 LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ-RA 1613
Query: 437 MIKTYQESEEIKSNELDAKLRV---TKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKE 493
+ ++ EI +L+A++ + E+ KQ+++ Q++ + +ELE+ + + E
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ---RELEEARASRDE 1670
Query: 494 GMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTA----DQLQEQ 549
+ + K+K LE E L+ ++EL+ + + E L D++ + L ++
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 550 LQRGKQEIENLKEEVESLNS---LINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSES 606
+R + I L+EE+E S L+ND RK ++ L ++ + Q
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLND------RFRKTTLQVDTLNAELAAERSAAQKSD 1784
Query: 607 NS---LQSQFDKVSCSESQLQSQCE-QMKQTNINLESRLLK-EEELRKEEVQTLQAELAC 661
N+ L+ Q ++ +L+ + + K T LE+++ + EE+L +E + A
Sbjct: 1785 NARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844
Query: 662 RQTE--VKALSTQVEELK---DELVTQRRKHASSIKDLTKQLQQA----------RRKL- 705
R+TE +K + QVE+ + D+ Q K + +K L +QL++A RRKL
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904
Query: 706 ----DQVESG-SYDKEVSSMGSRSSSSGSLNARSSAEDR 739
D E+ +EVS++ +R G ++ SS R
Sbjct: 1905 RELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGR 1943
>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
Length = 841
Score = 120 bits (301), Expect = 6e-27
Identities = 165/688 (23%), Positives = 309/688 (44%), Gaps = 103/688 (14%)
Query: 251 IKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEA 310
+ ++E + E +E + +QL + + + +L +E+A+ E+ KK E +
Sbjct: 189 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCR---- 244
Query: 311 MVMKYVRGEKESL--DLRKEKETLEKKLRDANKELEKNTNKIKQ-LSQEKGRLHQLYETK 367
++ EKE+L D R + E L+++ +K T K++Q L L +L + +
Sbjct: 245 -----LQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQR 299
Query: 368 EGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQA---- 423
+GE + L++ ++ + L AE ++ + + L++ T TQ
Sbjct: 300 QGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNML 359
Query: 424 KEEADQIRKNCQDMIKTYQE---SEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAK 480
+E+ + Q Y++ ++ +++L LR LE Q+QE + E +
Sbjct: 360 REQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE-QLQEIGQEKEQLTQE 418
Query: 481 IKELEDLKRTFKEGMDEL--RTLRTKVKCLED---ERLRTEDELSKYKEIINRQKAEIQN 535
++E K +DEL TL+ K + E+ RLR E E+ + R+ E+
Sbjct: 419 LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHE 478
Query: 536 LLDKVKTADQLQEQLQRGK---QEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFT 592
DK + ++L+ Q++ K +E+E L++ VE L + ++ + +G++ F
Sbjct: 479 --DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSM----DGAKG------WFE 526
Query: 593 ERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLL-KEEELRKEE 651
RL LQ Q Q Q E +KQ + L KEEEL+
Sbjct: 527 RRLKEAEESLQQ-----------------QQQEQEEALKQCREQHAAELKGKEEELQDVR 569
Query: 652 VQTLQAELACRQTEVKALSTQVEELKDELVTQR---RKHASSIKDLTKQLQQARRKLDQV 708
Q QA+ R +K +S+ +E+KD + QR +K ++++KDL +QL R++ D++
Sbjct: 570 DQLEQAQEE-RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKL 628
Query: 709 E-------------SGSYDKEVSSMGSRS-SSSGSLNARSSAEDRS--PENTGSSV---A 749
+ SG + +S M S S + +G ++ SS R E S+V +
Sbjct: 629 QERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARS 688
Query: 750 VDNFPQV-----------DKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTK 798
+ + PQ + A L +R+ Q+ EK++ +E + E++ +K+
Sbjct: 689 LSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSA 748
Query: 799 IIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQA 858
II++Y++ + +S A ++ L G ++ L P D L E+N+KLQ
Sbjct: 749 IIETYVM-DSRIDVSVAAGHTDRSGL---GSVLRDLVK--PGDENLR-----EMNKKLQN 797
Query: 859 VLEDTLLKNITLKENLQTLGTEIERLIK 886
+LE+ L KN+ L ++++ L EI RL K
Sbjct: 798 MLEEQLTKNMHLHKDMEVLSQEIVRLSK 825
Score = 45.8 bits (107), Expect = 2e-04
Identities = 77/411 (18%), Positives = 162/411 (39%), Gaps = 66/411 (16%)
Query: 545 QLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTE------RLTSK 598
QL ++L++ E+ +L+++V L+ + QK + S+K + +L +E +L S+
Sbjct: 26 QLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQ 85
Query: 599 NAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAE 658
+ ++++L ++F K+ QL+ + +Q+K+ + + + L E+ LQAE
Sbjct: 86 EEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEGAAG--AGVAQAGPLVDGELLRLQAE 143
Query: 659 LACRQTEVKALS--------------------------TQVEELKDELVTQRRKHASSIK 692
Q V AL T + + V + + K
Sbjct: 144 NTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEK 203
Query: 693 DLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDN 752
L + Q Q E+ +E++ + + R E + N S ++
Sbjct: 204 RLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFN-DSRNKIEE 262
Query: 753 FPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILR---EES 809
Q +A ++ R QK +++E + +L ++ R+ ++ + LR ++
Sbjct: 263 LQQRKEADHKAQLARTQKL----QQELEAANQSLAELRDQ-RQGERLEHAAALRALQDQV 317
Query: 810 GTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSL----------EINRK---- 855
S++A + + L+ + SL T EL++ E+ ++
Sbjct: 318 SIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEY 377
Query: 856 ---------LQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
L + L+++L N L E LQ +G E E+L + E + +K
Sbjct: 378 EDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK 428
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 120 bits (300), Expect = 7e-27
Identities = 198/952 (20%), Positives = 384/952 (40%), Gaps = 152/952 (15%)
Query: 7 IASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQ 66
+ S ++K + E E + + +E+ + E E K++SL +K N+ +++++
Sbjct: 844 LKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEK-----NDLQLQVQSE 898
Query: 67 ENYIPDHGGGEDSC-----------AKTDTGSENSEQIANFPSGNFAKHIS---KTNETE 112
+ D E+ C AK +E E+ S AK + K + +
Sbjct: 899 TENLMD---AEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLK 955
Query: 113 QKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLS 172
+ + + + L + A E + ++ ISK+ S L+E + L
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKS---LQEAHQQTLD 1012
Query: 173 TEFAEHRVPNGMNKGEHALV-----LFEKCVQDKYLQQ--EHIIKKLIKENKKHQELFVD 225
E NG+ K L L Q+K L+ E +KL + K QE +D
Sbjct: 1013 DLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 226 ICSEKDNLREELKK----------RTETEKQH----MNTIKQLESRIEELNKEVKASRDQ 271
+ ++K + E+LKK + + E+ H IK+L++RIEEL +E++A
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEH-- 1130
Query: 272 LIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRK--EK 329
T + +++ ++A+ +E+ +++ EEA A + + E E +R+ E+
Sbjct: 1131 ------TLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEE 1184
Query: 330 ETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHV 389
TL+ + A +K + + +L ++ L ++ + E E + L EID + +I
Sbjct: 1185 ATLQHEATAATLR-KKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIE--- 1240
Query: 390 IKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKS 449
A +K K+ ++ T + + ++ K + +Q + D+
Sbjct: 1241 -----ALSKSKSNIERTCRTVE------DQFSEIKAKDEQQTQLIHDL------------ 1277
Query: 450 NELDAKLRVTKGELEKQMQEK----SDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKV 505
N A+L+ GEL +++EK S + A ++LE+LKR +E E +
Sbjct: 1278 NMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEE---ETKAKNAMA 1334
Query: 506 KCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVE 565
L+ R D L + E KAE+Q L K ++ Q + + I+ +E E
Sbjct: 1335 HALQSSR-HDCDLLREQYEEEQEAKAELQRALSKA-NSEVAQWRTKYETDAIQRTEELEE 1392
Query: 566 SLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQS 625
+ L LQ+ E TE SK A L+ LQ + + + + +
Sbjct: 1393 AKKKLAQRLQEAEEN-----------TETANSKCASLEKTKQRLQGEVEDLMRDLERSHT 1441
Query: 626 QCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQV-------EELKD 678
C + + N + L + K+++ QAEL Q E ++LST++ EE+ D
Sbjct: 1442 ACATLDKKQRNFDKVLAE----WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD 1497
Query: 679 ELVTQRRKHAS---SIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSS 735
+L T RR++ + I DLT+Q+ + + L + E +
Sbjct: 1498 QLETLRRENKNLQEEISDLTEQIAETGKNLQEAE---------------------KTKKL 1536
Query: 736 AEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRK 795
E + + V+ + +++ ++ + L + + + K+ ++ I+QL ++
Sbjct: 1537 VEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQR 1596
Query: 796 KTKIIQSYI---LREESGTL---SSEASDFN--KVHLSRRGGIMAS------LYTSHPAD 841
+ +QS + +R + L D N ++ L MA D
Sbjct: 1597 AAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKD 1656
Query: 842 NGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQ 893
+ L L+ +L N L+ L +N L E L+ + +E+ + + EQ
Sbjct: 1657 SQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQ 1708
Score = 113 bits (282), Expect = 9e-25
Identities = 149/719 (20%), Positives = 318/719 (44%), Gaps = 53/719 (7%)
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
IK L+K + +E+ + + + +EEL + K+ + L +L +V++
Sbjct: 840 IKPLLKSAEAEKEM-ATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKE 328
+ L+ + + ++ + ++++ ++ EE + +V K E + L+++
Sbjct: 899 TENLMDAEERCEGLIKSKIL-LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD 957
Query: 329 KETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYE--TKEGETTRLIRE--IDKL--K 382
+ LE L KE NK+K LS+E L + TKE ++ + + +D L +
Sbjct: 958 IDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVE 1017
Query: 383 EDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQ 442
ED + +IK+ KL+ + D + + ++ K+ L +AK + + K Q+ I +
Sbjct: 1018 EDKVNGLIKI---NAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE 1074
Query: 443 ESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMH----HAKIKELEDLKRTFKEGMDEL 498
++ +++ KL+ + EL Q+Q K D ++H KIKEL+ +E ++
Sbjct: 1075 NDKQ----QIEEKLKKKEFEL-SQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE 1129
Query: 499 RTLRTKVKCLEDERLRTEDELS-KYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEI 557
TLR K++ + R +E+S + +E A+I+ ++K + A + Q+ ++++
Sbjct: 1130 HTLRAKIEKQRSDLARELEEISERLEEASGATSAQIE--MNKKREA-----EFQKMRRDL 1182
Query: 558 ENLKEEVESLNSLINDLQKD-IEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKV 616
E + E+ + + Q D + ++ L ++L + ++L+ E + + S + +
Sbjct: 1183 EEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL 1242
Query: 617 SCSESQLQSQCEQMK------QTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALS 670
S S+S ++ C ++ + +++L+ + ++K +QT EL+ R E ++L
Sbjct: 1243 SKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLI 1302
Query: 671 TQVEELKDELVTQRRKHASSIKDLTK-------QLQQARRKLDQVESGSYDKEVSSMGSR 723
+Q+ + K L Q + +++ TK LQ +R D + Y++E +
Sbjct: 1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLRE-QYEEEQEAKAEL 1361
Query: 724 SSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFME 783
+ N+ A+ R+ T + + + K L +R+ ++ N K +E
Sbjct: 1362 QRALSKANS-EVAQWRTKYETDAIQRTEELEEA-KKKLAQRLQEAEENTETANSKCASLE 1419
Query: 784 DHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGI---MASLYTSHPA 840
++L E+ + ++ TL + +F+KV + + A L +
Sbjct: 1420 KTKQRLQGEVEDLMRDLER--SHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKE 1477
Query: 841 DNGLTLELSLEINRKLQAV--LEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
L+ EL N + V LE +N L+E + L +I K+ E E +TKK
Sbjct: 1478 SRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAE-KTKK 1535
Score = 104 bits (260), Expect = 3e-22
Identities = 135/672 (20%), Positives = 292/672 (43%), Gaps = 86/672 (12%)
Query: 103 KHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFI----SKIKSVSA 158
+ I +QK+ + EL+ ++N + S+S + + T + + S+IK+
Sbjct: 1209 EQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE 1268
Query: 159 SE-DLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENK 217
+ L+ ++ + + + + + + E + K Q Q E + +++ +E K
Sbjct: 1269 QQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETK 1328
Query: 218 KHQELFVDICSEK---DNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIA 274
+ + S + D LRE+ ++ E + + L+ + + N EV R +
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAE-------LQRALSKANSEVAQWRTKYET 1381
Query: 275 QDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKE---- 330
+ +++ K++AQR+++A + E A + ++ R + E DL ++ E
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHT 1441
Query: 331 ---TLEKKLRDANK--------------ELEKNTNKIKQLSQEKGRLHQLYETKEGETTR 373
TL+KK R+ +K ELE + + LS E ++ YE +
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 374 LIREIDKLKEDIN-------------SHVIKVKWAQNKLKAEMD-SHKETKDKLKETTTK 419
L RE L+E+I+ K K + K+++ + +E + L+ +K
Sbjct: 1502 LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561
Query: 420 LTQAKEEADQIRKNC-QDMIKTYQESEEIKSNE----------LDAKLRVTKGELEKQMQ 468
+ + + E Q++ + +I+ +E E++K N LDA++R L + +
Sbjct: 1562 ILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKK 1621
Query: 469 EKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLE---DERLRTEDELSKYKEI 525
+ D EM +L R E LRT++ ++K + D+ LR+ ++L + I
Sbjct: 1622 MEGDLNEME----IQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAI 1677
Query: 526 INRQKAEIQNLLDKVKTADQLQEQLQR-GKQEIENLKEEVESLN----SLIN---DLQKD 577
+ R+ + L+++K A + E+ +R +QE+ + + V+ L+ SLIN L+ D
Sbjct: 1678 VERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEAD 1737
Query: 578 IEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINL 637
I + + + K + +++ + + K + + L+ + ++QT +L
Sbjct: 1738 IAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1797
Query: 638 ESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQ 697
+ RL + E+L L + +++ L +V EL++EL ++++ A ++K K
Sbjct: 1798 QHRLDEAEQL----------ALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKY 1847
Query: 698 LQQARRKLDQVE 709
++ + Q E
Sbjct: 1848 ERKVKEMTYQAE 1859
Score = 67.8 bits (164), Expect = 4e-11
Identities = 104/584 (17%), Positives = 238/584 (40%), Gaps = 80/584 (13%)
Query: 87 SENSEQIANFPSGNFAKHISKTNETEQ---KVTQILVELRSSTFPESAN------EKTYS 137
S+ + ++A + + I +T E E+ K+ Q L E +T E+AN EKT
Sbjct: 1366 SKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENT--ETANSKCASLEKTKQ 1423
Query: 138 ESPYDTDCTKKFISKIKSVSASEDL---------------LEEIESELLSTEFAEHRVPN 182
+ + + + + + A+ D L+E ++EL + + +
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLST 1483
Query: 183 GMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTE 242
+ K +A +E+ V ++ L +ENK QE D+ + + L++ +
Sbjct: 1484 ELFKMRNA---YEEVVDQ--------LETLRRENKNLQEEISDLTEQIAETGKNLQEAEK 1532
Query: 243 TEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQR---MEQANK 299
T+K L+ +EE+ ++ +++ + +L +++ ++ +EQ +
Sbjct: 1533 TKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKR 1592
Query: 300 KCEEARQEKEAMVMKYVRGEKESLDLRKEKE----TLEKKLRDANKELEKNTNKIK---- 351
+ A + ++++ +R ++L L+K+ E +E +L +N+++ + ++
Sbjct: 1593 NSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQG 1652
Query: 352 QLSQEKGRLHQLYETKEGETTRLI---REIDKLKEDINSHVIKVKWAQNKLKAEMDSHKE 408
QL + L + E +L R L E++ + ++ + + +
Sbjct: 1653 QLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLD 1712
Query: 409 TKDK---LKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEK 465
D+ L T L K++ + CQ ++ +E ++ E AK +T +
Sbjct: 1713 ASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVEN--SIQESRNAEEKAKKAITDAAMMA 1770
Query: 466 QMQEKSDQLEMHHAKIKE-LEDLKRTFKEGMDELRTLRTK-----VKCLEDERLRTEDEL 519
+ +K H ++K+ LE + + +DE L K ++ LE+ E+EL
Sbjct: 1771 EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL 1830
Query: 520 S------------------KYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLK 561
K KE+ + + + +N+L D+LQ +++ K++ E +
Sbjct: 1831 DVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAE 1890
Query: 562 EEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSE 605
E+ + S +Q ++E + +R +L +K+ + S+
Sbjct: 1891 EQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQ 1934
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 119 bits (298), Expect = 1e-26
Identities = 172/777 (22%), Positives = 337/777 (43%), Gaps = 105/777 (13%)
Query: 82 KTDTGSENSEQI-ANFPSGNFAKHI--SKTNETEQKVTQILVELRSST--FPESANEKTY 136
K T S+ +QI +N+ H+ SK E E+K+ ++ E+ ++T + ++
Sbjct: 885 KNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKL 944
Query: 137 SESPYDTDCTKKFISKIKSVS----------ASEDLLEEIESELLSTEFA------EHRV 180
+ D T +S+I ++ + ED L + +LL ++ E+R+
Sbjct: 945 MHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRI 1004
Query: 181 --PNGMNKGEHAL-VLFEKC--VQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLRE 235
PN N ++ ++E+C + ++ H I++L ++ +K Q E + L+E
Sbjct: 1005 QEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKE 1064
Query: 236 -ELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLH------- 287
E K + + K+ I+QL+ ++E N + D I V K A+ +L
Sbjct: 1065 KEHKNQDDLLKEKETLIQQLKEELQEKN----VTLDVQIQHVVEGKRALSELTQGVTCYK 1120
Query: 288 ---KEMAQRMEQANKKCEEARQ------EKEAMVMKYVRGEKESLDLRKEKETLEKKLRD 338
KE+ +E +C + + EKE++++K R KE ++ + K +D
Sbjct: 1121 AKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKE---FQEHLQDSVKNTKD 1177
Query: 339 ANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNK 398
N + K +I QL+ + L + KE E +E +KLKE++++ + +
Sbjct: 1178 LNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQ----N 1233
Query: 399 LKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRV 458
LKA++ +E LKE KLT AK++ Q++K M + D LR+
Sbjct: 1234 LKADLQRKEEDYADLKE---KLTDAKKQIKQVQKEVSVM------------RDEDKLLRI 1278
Query: 459 TKGELEKQMQEKSDQLEMHHAKIKELED------LKRTFKEGMDELRTLRTKVKCLEDER 512
ELEK+ + S +L+M I++L++ ++ ++ + L K K +ED R
Sbjct: 1279 KINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMR 1338
Query: 513 LRTEDELS---KYKEIINRQKAEIQNLLD-----KVKTADQLQEQLQRGKQEIENLKEEV 564
+ E++ + +++ + E++ L K K D + QR +E EN + +
Sbjct: 1339 MTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVL 1398
Query: 565 ESLNSLINDLQKD---IEGSRKR--ESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCS 619
L +L ++LQ+ RK+ E +++L T+ ++N + E ++
Sbjct: 1399 GKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIR-NKEMKKYAEDRERFFKQ 1457
Query: 620 ESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDE 679
+++++ Q+ + +S L K E R + V L+ +L + ++E+LK
Sbjct: 1458 QNEMEILTAQLTEK----DSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLK-R 1512
Query: 680 LVTQRRKHASSIKDL-TKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAE- 737
++++ K + I D+ K++ A Q E S E+S S + S E
Sbjct: 1513 IISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTEN 1572
Query: 738 DRSPENTGSSVAVDNFPQVDKAMLIER-------IVRLQKAHARKNEKIEFMEDHIK 787
D+S + + P M ++ V++ KA RK+ ++E ED +K
Sbjct: 1573 DQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEME--EDLVK 1627
Score = 68.2 bits (165), Expect = 3e-11
Identities = 201/945 (21%), Positives = 367/945 (38%), Gaps = 156/945 (16%)
Query: 36 SKLEN-ESKLLSLNTDKTL-CQPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGSENSEQI 93
+KL N S+ S+ T K L + +E + I E + D G E + KT E +
Sbjct: 342 TKLNNASSRSHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTM-KTQNEGERLRET 400
Query: 94 ANFPSG--NFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFIS 151
N + K I+ +E+ Q V R S Y +S ++ K I
Sbjct: 401 GNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTH------YFQSFFNG---KGKIC 451
Query: 152 KIKSVSASEDLLEEIESELLSTEFAEHR-VPNGMNKGEHALVLFEKCVQDKYLQQEHIIK 210
I ++S +E + L + A+ VP+ +N + L K QD L K
Sbjct: 452 MIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSK 511
Query: 211 KL-IKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTI------------------ 251
L +K E ++ E ++L EEL+ ET+ +
Sbjct: 512 ILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHE 571
Query: 252 --KQLESRIEELNKE-VKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEK 308
++L IE+L K+ + +++L + + Q+ + AQR +A+ K E QE+
Sbjct: 572 EKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQR--EADFK-ETLLQER 628
Query: 309 EAMVMKYVRGEKESLDLRKEKETLEKKLRD----------ANKELEKNTNKIK-QLSQEK 357
E + R DL + +T E+ +D A LE N+IK +L++ K
Sbjct: 629 EILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACLELKFNQIKAELAKTK 688
Query: 358 GRLHQLYET---KEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLK 414
G L + E +E E+ LI+E++ + I + ++K N + + D+ E ++
Sbjct: 689 GELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKS 748
Query: 415 --ETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSD 472
E T K + + I N +T + ++ KS + RV + EL Q E
Sbjct: 749 HMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENEL--QQDEPPA 806
Query: 473 QLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAE 532
+ H ED K++ +R + +ED R+ E+
Sbjct: 807 KKGSIHVSSAITEDQKKS--------EEVRPNIAEIEDIRVLQENN-------------- 844
Query: 533 IQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFT 592
+ L+ L + E++N KEE LN I Q+++ S K
Sbjct: 845 -----------EGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEK--------- 884
Query: 593 ERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEV 652
KN L E +QS +D ++ +E +Q K N E +++K E+
Sbjct: 885 -----KNLTLSKEVQQIQSNYD-IAIAELHVQ------KSKNQEQEEKIMK----LSNEI 928
Query: 653 QTLQAELACRQTEVKALSTQVEELK--DELVTQRRKHASSIKDLTKQLQQARRKLDQVES 710
+T + +++K + T+++EL+ D + +++DL+ ++ Q++
Sbjct: 929 ETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDL 988
Query: 711 GSYDKEVSSMGS--RSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRL 768
D VS R N+ S+ + E V + L ++I +L
Sbjct: 989 LGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKL 1048
Query: 769 Q---------------KAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLS 813
Q K H +++ ++ E I+QL EE+++K + I G +
Sbjct: 1049 QAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRA 1108
Query: 814 -SEASDFNKVHLSRRGGIMASLYT-----SHPAD------NGLTLELSLEIN-RKLQAVL 860
SE + + ++ + L T SH A ++ L LE N ++ Q L
Sbjct: 1109 LSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHL 1168
Query: 861 EDTL-------LKNITLKENLQTLGTEIERLIKHQHELEQRTKKT 898
+D++ +K + LKE + L ++ + KH +L++ ++T
Sbjct: 1169 QDSVKNTKDLNVKELKLKEEITQLTNNLQDM-KHLLQLKEEEEET 1212
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 118 bits (296), Expect = 2e-26
Identities = 200/961 (20%), Positives = 388/961 (40%), Gaps = 144/961 (14%)
Query: 7 IASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQ 66
+ S ++K + E + + + +E+ + E E K+++L +K N+ +++A+
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK-----NDLQLQVQAE 900
Query: 67 ENYIPDHGGGEDSCAKTDTG-----------SENSEQIANFPSGNFAKHISKTNETEQKV 115
+ D D KT +E+ E+I + K + +E ++ +
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960
Query: 116 TQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEF 175
+ + L + A E + + I+K+ + + L+E + L
Sbjct: 961 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL---TKEKKALQEAHQQTLDDLQ 1017
Query: 176 AEHRVPNGMNKGEHALV-----LFEKCVQDKYLQQ--EHIIKKLIKENKKHQELFVDICS 228
AE N + K + L L Q+K L+ E +KL + K QE +DI +
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 229 EKDNLREELKKRT----------ETEK----QHMNTIKQLESRIEELNKEVKASRDQLIA 274
EK L E+LKK+ E E+ Q IK+L++RIEEL +E++A R
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAER----- 1132
Query: 275 QDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRK--EKETL 332
++ ++ ++++ +E+ +++ EEA A + + E E +R+ E+ TL
Sbjct: 1133 ---ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 333 EKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKV 392
+ + A +K+ + + +L ++ L ++ + E E + + EID L ++
Sbjct: 1190 QHEATAATLR-KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV------- 1241
Query: 393 KWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNEL 452
ET K K K+ + E DQ+ + +K+ +E ++ N+L
Sbjct: 1242 ---------------ETVSKAKGNLEKMCRTLE--DQLSE-----LKSKEEEQQRLINDL 1279
Query: 453 DA---KLRVTKGELEKQMQEK----SDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKV 505
A +L+ GE +Q+ EK S A +++E+LKR +E E++
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE---EIKAKNALA 1336
Query: 506 KCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKT----------------ADQLQEQ 549
L+ R D L + E KAE+Q L K T ++L+E
Sbjct: 1337 HALQSSR-HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEA 1395
Query: 550 LQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSL 609
++ Q ++ +E VE++N+ L+K + + +L+L ER + A L +
Sbjct: 1396 KKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK---- 1451
Query: 610 QSQFDKV------SCSESQLQSQCEQMKQTNINLESRLLK---EEELRKEEVQTLQAELA 660
Q FDK+ C E+ + + Q + ++ E +K EE L ++++TL+ E
Sbjct: 1452 QRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL--DQLETLKRENK 1509
Query: 661 CRQTEVKALSTQVEE---LKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEV 717
Q E+ L+ Q+ E EL +++ +L L++A L+ E ++
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQL 1569
Query: 718 SSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIER--IVRLQKAHARK 775
+S + + D+ N V++ A + R +RL+K
Sbjct: 1570 ELNQVKSEVDRKIAEKDEEIDQLKRN--HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1627
Query: 776 NEKIEFMEDHIKQLVEE----IRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIM 831
++E +H ++ E R I++ + + S E + RR ++
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 832 ASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHEL 891
+ L +LE + + + E LL E +Q L T+ LI + +L
Sbjct: 1688 QAEIEE--------LRATLEQTERSRKIAEQELL---DASERVQLLHTQNTSLINTKKKL 1736
Query: 892 E 892
E
Sbjct: 1737 E 1737
Score = 115 bits (289), Expect = 1e-25
Identities = 111/580 (19%), Positives = 278/580 (47%), Gaps = 67/580 (11%)
Query: 163 LEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENK----- 217
+EE++ +L A++ + + + H L + +++ + + + L K N
Sbjct: 1318 IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQW 1377
Query: 218 --KHQELFVDICSEKDNLREELKKRTETEKQHMNTI-----------KQLESRIEELNKE 264
K++ + E + +++L +R + ++H+ + ++L++ +E+L +
Sbjct: 1378 RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 265 VKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAM---VMKYVRGEKE 321
V+ + A D +N ++ E Q+ E+ + + E +++E ++ + K +E
Sbjct: 1438 VERTNAACAALDKKQRN-FDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496
Query: 322 SLD----LRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIRE 377
SLD L++E + L++++ D +++ + +I +L + K ++ Q ++ E + E
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ----EKCELQAALEE 1552
Query: 378 IDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDM 437
+ E +++++ N++K+E+D K+ + EE DQ+++N +
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDR-------------KIAEKDEEIDQLKRNHIRI 1599
Query: 438 IKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDE 497
+++ Q + + + + +R+ K ++E + E +++++HA E L R ++
Sbjct: 1600 VESMQSTLDAEIRSRNDAIRLKK-KMEGDLNEM--EIQLNHANRMAAEAL-RNYRNTQGI 1655
Query: 498 LRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVK-TADQLQEQLQRGKQE 556
L+ + + D+ LR++++L + ++ R+ +Q +++++ T +Q + + +QE
Sbjct: 1656 LKDTQIHL----DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE 1711
Query: 557 IENLKEEVESLN----SLIND---LQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSL 609
+ + E V+ L+ SLIN L+ DI + ++L K + +++ +
Sbjct: 1712 LLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMM 1771
Query: 610 QSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELR----KEEVQTLQAELACRQTE 665
+ K + + L+ + M+QT +L+ RL + E+L K+++Q L+A + + E
Sbjct: 1772 AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGE 1831
Query: 666 VKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKL 705
V++ ++ E V RKH +K+LT Q ++ R+ +
Sbjct: 1832 VES----EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI 1867
Score = 63.2 bits (152), Expect = 1e-09
Identities = 77/409 (18%), Positives = 177/409 (43%), Gaps = 53/409 (12%)
Query: 229 EKDNLREELKKRTETEKQHMNTIKQLES---RIEELNKEVKASRDQLIAQDVTAKNAVQQ 285
E NL++E+ TE + I +LE ++E+ E++A+ ++ A + + +
Sbjct: 1507 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1566
Query: 286 LHKEMAQRMEQANKKCEEARQEKEAMVMKYVR---GEKESLDL----RKEKETLEKKLRD 338
+ E+ Q + ++K E +E + + ++R + +LD R + L+KK+
Sbjct: 1567 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626
Query: 339 ANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNK 398
E+E N +++ E R ++ + +T + + + +ED+ + V+ N
Sbjct: 1627 DLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL 1686
Query: 399 LKAEMDSHKETKDKLKETTT----KLTQAKEEADQIRKNCQDMIKTYQESE--------- 445
L+AE++ + T ++ + + +L A E + +I T ++ E
Sbjct: 1687 LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGE 1746
Query: 446 ------EIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKE-----LEDLKRTFKE- 493
E ++ E AK +T + + +K H ++K+ ++DL+ E
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806
Query: 494 -------GMDELRTLRTKVKCLE----DERLRTEDELS-------KYKEIINRQKAEIQN 535
G +++ L +V+ LE E+ R + + + KE+ + + + +N
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866
Query: 536 LLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKR 584
+L D+LQ +++ K++ E +E+ + + LQ ++E + +R
Sbjct: 1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEER 1915
Score = 58.5 bits (140), Expect = 3e-08
Identities = 86/415 (20%), Positives = 180/415 (43%), Gaps = 48/415 (11%)
Query: 163 LEEIESELLSTEFAEHRVPNGMN--KGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQ 220
LEE E+ L E R+ +N K E + EK + L++ HI ++++ +
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHI--RIVESMQS-- 1605
Query: 221 ELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNK-EVKASRDQLIAQDVTA 279
L +I S D +R LKK+ E + + ++E ++ N+ +A R+ Q +
Sbjct: 1606 TLDAEIRSRNDAIR--LKKKMEGD------LNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 280 KNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLD-LRKEKETLEKKLRD 338
Q+H + A R ++ K+ + + ++ + + +L+ + ++ E++L D
Sbjct: 1658 DT---QIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLD 1714
Query: 339 ANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNK 398
A++ ++ + L K +L +GE +++E +E + +
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774
Query: 399 LKAEMDS--HKETKDKLKETTTKLTQAK-EEADQIRKNCQDMIKTYQESEEIKSNELDAK 455
LK E D+ H E K E T K Q + +EA+Q+ + + + +L+A+
Sbjct: 1775 LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLAL----------KGGKKQIQKLEAR 1824
Query: 456 LRVTKGELEKQMQEKSDQ---LEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDER 512
+R +GE+E + + ++ L H ++KEL T++ D LR L+D
Sbjct: 1825 VRELEGEVESEQKRNAEAVKGLRKHERRVKEL-----TYQTEEDRKNILR-----LQDLV 1874
Query: 513 LRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESL 567
+ + ++ YK + + L K + +LQ +L+ ++ + + +V L
Sbjct: 1875 DKLQAKVKSYKRQAEEAEEQSNTNLAKFR---KLQHELEEAEERADIAESQVNKL 1926
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 118 bits (296), Expect = 2e-26
Identities = 200/961 (20%), Positives = 388/961 (40%), Gaps = 144/961 (14%)
Query: 7 IASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQ 66
+ S ++K + E + + + +E+ + E E K+++L +K N+ +++A+
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK-----NDLQLQVQAE 900
Query: 67 ENYIPDHGGGEDSCAKTDTG-----------SENSEQIANFPSGNFAKHISKTNETEQKV 115
+ D D KT +E+ E+I + K + +E ++ +
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 960
Query: 116 TQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEF 175
+ + L + A E + + I+K+ + + L+E + L
Sbjct: 961 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKL---TKEKKALQEAHQQTLDDLQ 1017
Query: 176 AEHRVPNGMNKGEHALV-----LFEKCVQDKYLQQ--EHIIKKLIKENKKHQELFVDICS 228
AE N + K + L L Q+K L+ E +KL + K QE +DI +
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 229 EKDNLREELKKRT----------ETEK----QHMNTIKQLESRIEELNKEVKASRDQLIA 274
EK L E+LKK+ E E+ Q IK+L++RIEEL +E++A R
Sbjct: 1078 EKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAER----- 1132
Query: 275 QDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRK--EKETL 332
++ ++ ++++ +E+ +++ EEA A + + E E +R+ E+ TL
Sbjct: 1133 ---ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1189
Query: 333 EKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKV 392
+ + A +K+ + + +L ++ L ++ + E E + + EID L ++
Sbjct: 1190 QHEATAATLR-KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNV------- 1241
Query: 393 KWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNEL 452
ET K K K+ + E DQ+ + +K+ +E ++ N+L
Sbjct: 1242 ---------------ETVSKAKGNLEKMCRTLE--DQLSE-----LKSKEEEQQRLINDL 1279
Query: 453 DA---KLRVTKGELEKQMQEK----SDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKV 505
A +L+ GE +Q+ EK S A +++E+LKR +E E++
Sbjct: 1280 TAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE---EIKAKNALA 1336
Query: 506 KCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKT----------------ADQLQEQ 549
L+ R D L + E KAE+Q L K T ++L+E
Sbjct: 1337 HALQSSR-HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEA 1395
Query: 550 LQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSL 609
++ Q ++ +E VE++N+ L+K + + +L+L ER + A L +
Sbjct: 1396 KKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKK---- 1451
Query: 610 QSQFDKV------SCSESQLQSQCEQMKQTNINLESRLLK---EEELRKEEVQTLQAELA 660
Q FDK+ C E+ + + Q + ++ E +K EE L ++++TL+ E
Sbjct: 1452 QRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL--DQLETLKRENK 1509
Query: 661 CRQTEVKALSTQVEE---LKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEV 717
Q E+ L+ Q+ E EL +++ +L L++A L+ E ++
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQL 1569
Query: 718 SSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIER--IVRLQKAHARK 775
+S + + D+ N V++ A + R +RL+K
Sbjct: 1570 ELNQVKSEVDRKIAEKDEEIDQLKRN--HIRIVESMQSTLDAEIRSRNDAIRLKKKMEGD 1627
Query: 776 NEKIEFMEDHIKQLVEE----IRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIM 831
++E +H ++ E R I++ + + S E + RR ++
Sbjct: 1628 LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLL 1687
Query: 832 ASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHEL 891
+ L +LE + + + E LL E +Q L T+ LI + +L
Sbjct: 1688 QAEIEE--------LRATLEQTERSRKIAEQELL---DASERVQLLHTQNTSLINTKKKL 1736
Query: 892 E 892
E
Sbjct: 1737 E 1737
Score = 115 bits (289), Expect = 1e-25
Identities = 111/580 (19%), Positives = 278/580 (47%), Gaps = 67/580 (11%)
Query: 163 LEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENK----- 217
+EE++ +L A++ + + + H L + +++ + + + L K N
Sbjct: 1318 IEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQW 1377
Query: 218 --KHQELFVDICSEKDNLREELKKRTETEKQHMNTI-----------KQLESRIEELNKE 264
K++ + E + +++L +R + ++H+ + ++L++ +E+L +
Sbjct: 1378 RTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1437
Query: 265 VKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAM---VMKYVRGEKE 321
V+ + A D +N ++ E Q+ E+ + + E +++E ++ + K +E
Sbjct: 1438 VERTNAACAALDKKQRN-FDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEE 1496
Query: 322 SLD----LRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIRE 377
SLD L++E + L++++ D +++ + +I +L + K ++ Q ++ E + E
Sbjct: 1497 SLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQ----EKCELQAALEE 1552
Query: 378 IDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDM 437
+ E +++++ N++K+E+D K+ + EE DQ+++N +
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDR-------------KIAEKDEEIDQLKRNHIRI 1599
Query: 438 IKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDE 497
+++ Q + + + + +R+ K ++E + E +++++HA E L R ++
Sbjct: 1600 VESMQSTLDAEIRSRNDAIRLKK-KMEGDLNEM--EIQLNHANRMAAEAL-RNYRNTQGI 1655
Query: 498 LRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVK-TADQLQEQLQRGKQE 556
L+ + + D+ LR++++L + ++ R+ +Q +++++ T +Q + + +QE
Sbjct: 1656 LKDTQIHL----DDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQE 1711
Query: 557 IENLKEEVESLN----SLIND---LQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSL 609
+ + E V+ L+ SLIN L+ DI + ++L K + +++ +
Sbjct: 1712 LLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMM 1771
Query: 610 QSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELR----KEEVQTLQAELACRQTE 665
+ K + + L+ + M+QT +L+ RL + E+L K+++Q L+A + + E
Sbjct: 1772 AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGE 1831
Query: 666 VKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKL 705
V++ ++ E V RKH +K+LT Q ++ R+ +
Sbjct: 1832 VES----EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNI 1867
Score = 63.2 bits (152), Expect = 1e-09
Identities = 77/409 (18%), Positives = 177/409 (43%), Gaps = 53/409 (12%)
Query: 229 EKDNLREELKKRTETEKQHMNTIKQLES---RIEELNKEVKASRDQLIAQDVTAKNAVQQ 285
E NL++E+ TE + I +LE ++E+ E++A+ ++ A + + +
Sbjct: 1507 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILR 1566
Query: 286 LHKEMAQRMEQANKKCEEARQEKEAMVMKYVR---GEKESLDL----RKEKETLEKKLRD 338
+ E+ Q + ++K E +E + + ++R + +LD R + L+KK+
Sbjct: 1567 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG 1626
Query: 339 ANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNK 398
E+E N +++ E R ++ + +T + + + +ED+ + V+ N
Sbjct: 1627 DLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL 1686
Query: 399 LKAEMDSHKETKDKLKETTT----KLTQAKEEADQIRKNCQDMIKTYQESE--------- 445
L+AE++ + T ++ + + +L A E + +I T ++ E
Sbjct: 1687 LQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGE 1746
Query: 446 ------EIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKE-----LEDLKRTFKE- 493
E ++ E AK +T + + +K H ++K+ ++DL+ E
Sbjct: 1747 MEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1806
Query: 494 -------GMDELRTLRTKVKCLE----DERLRTEDELS-------KYKEIINRQKAEIQN 535
G +++ L +V+ LE E+ R + + + KE+ + + + +N
Sbjct: 1807 EQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKN 1866
Query: 536 LLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKR 584
+L D+LQ +++ K++ E +E+ + + LQ ++E + +R
Sbjct: 1867 ILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEER 1915
Score = 58.5 bits (140), Expect = 3e-08
Identities = 86/415 (20%), Positives = 180/415 (43%), Gaps = 48/415 (11%)
Query: 163 LEEIESELLSTEFAEHRVPNGMN--KGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQ 220
LEE E+ L E R+ +N K E + EK + L++ HI ++++ +
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHI--RIVESMQS-- 1605
Query: 221 ELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNK-EVKASRDQLIAQDVTA 279
L +I S D +R LKK+ E + + ++E ++ N+ +A R+ Q +
Sbjct: 1606 TLDAEIRSRNDAIR--LKKKMEGD------LNEMEIQLNHANRMAAEALRNYRNTQGILK 1657
Query: 280 KNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLD-LRKEKETLEKKLRD 338
Q+H + A R ++ K+ + + ++ + + +L+ + ++ E++L D
Sbjct: 1658 DT---QIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLD 1714
Query: 339 ANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNK 398
A++ ++ + L K +L +GE +++E +E + +
Sbjct: 1715 ASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774
Query: 399 LKAEMDS--HKETKDKLKETTTKLTQAK-EEADQIRKNCQDMIKTYQESEEIKSNELDAK 455
LK E D+ H E K E T K Q + +EA+Q+ + + + +L+A+
Sbjct: 1775 LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLAL----------KGGKKQIQKLEAR 1824
Query: 456 LRVTKGELEKQMQEKSDQ---LEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDER 512
+R +GE+E + + ++ L H ++KEL T++ D LR L+D
Sbjct: 1825 VRELEGEVESEQKRNAEAVKGLRKHERRVKEL-----TYQTEEDRKNILR-----LQDLV 1874
Query: 513 LRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESL 567
+ + ++ YK + + L K + +LQ +L+ ++ + + +V L
Sbjct: 1875 DKLQAKVKSYKRQAEEAEEQSNTNLAKFR---KLQHELEEAEERADIAESQVNKL 1926
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 118 bits (296), Expect = 2e-26
Identities = 197/991 (19%), Positives = 410/991 (41%), Gaps = 165/991 (16%)
Query: 13 DKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQP------------NEHN 60
+K+ + EL+E +L +L+ +++ +LN + C E N
Sbjct: 866 EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMN 925
Query: 61 NRIEAQENYIPDHGGG----EDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVT 116
R+E +E + ED C++ ++ E AK + + TE KV
Sbjct: 926 ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLEL-------TLAKVEKEKHATENKVK 978
Query: 117 QILVELRSS-------TFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESE 169
+ E+ T + A ++ + ++ D + K+ S+S S+ LE+ +
Sbjct: 979 NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEE---DKVNSLSKSKVKLEQQVDD 1035
Query: 170 LLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSE 229
L + E +V + + + +KL + K QE +D+ ++
Sbjct: 1036 LEGSLEQEKKVRMDLERAK---------------------RKLEGDLKLTQESIMDLEND 1074
Query: 230 KDNLREELKK----------RTETEK----QHMNTIKQLESRIEELNKEVKASRDQLIAQ 275
K L E+LKK + E E+ Q +K+ ++RIEEL +E++A R
Sbjct: 1075 KLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAER------ 1128
Query: 276 DVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRK--EKETLE 333
TA+ V++L ++++ +E+ +++ EEA + + E E +R+ E+ TL+
Sbjct: 1129 --TARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQ 1186
Query: 334 KKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVK 393
+ A +K+ + + +L ++ L ++ + E E + E+D + ++ +IK K
Sbjct: 1187 HEATAAALR-KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM-EQIIKAK 1244
Query: 394 WAQNKLKAEM-DSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNEL 452
K+ + D E + KL+E L + +++ ++ + +E E + S
Sbjct: 1245 ANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLT 1304
Query: 453 DAKLRVTK--GELEKQMQEKS-----------------DQL-EMHHAKIKELEDLKRTFK 492
KL T+ +L++Q++E+ D L E + + + +L+R
Sbjct: 1305 RGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLS 1364
Query: 493 EGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKT-ADQLQEQLQ 551
+ E+ RTK E + ++ +EL + K+ + ++ + + ++ V L++
Sbjct: 1365 KANSEVAQWRTK---YETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKH 1421
Query: 552 RGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQS 611
R + EIE+L +VE N+ L K K +E E S+ Q E+ SL +
Sbjct: 1422 RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1481
Query: 612 QFDKVSCSESQLQSQCEQMKQTNINLE--------------------SRLLKEEELRKEE 651
+ K+ + + E K+ N NL+ ++ K+ E+ K E
Sbjct: 1482 ELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLE 1541
Query: 652 VQTL--QAELACRQTEVKALSTQVE--ELKDELVTQRRKHASSIKDLTKQLQQARRKLDQ 707
+Q+ +AE + E K L Q+E ++K E+ RK A +++ + + +R +D
Sbjct: 1542 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEI---ERKLAEKDEEMEQAKRNHQRVVDS 1598
Query: 708 VESGSYDKEVSSMGS----RSSSSGSLNA---------RSSAEDRSPENTGSSVAVDNFP 754
+++ S D E S + G LN R +AE + + S+ D
Sbjct: 1599 LQT-SLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI 1657
Query: 755 QVDKAM-----LIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREES 809
Q+D A+ L E I ++ R+N ++ + ++ +VE+ + K+ + ++
Sbjct: 1658 QLDDAVRANDDLKENIAIVE----RRNNLLQAELEELRAVVEQTERSRKLAEQELIETSE 1713
Query: 810 GTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNIT 869
+ + + ++ ++ M S T ++ ++ K + + D +
Sbjct: 1714 RVQLLHSQNTSLINQKKK---MESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEE 1770
Query: 870 LKE------NLQTLGTEIERLIKH-QHELEQ 893
LK+ +L+ + +E+ IK QH L++
Sbjct: 1771 LKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801
Score = 106 bits (265), Expect = 8e-23
Identities = 162/727 (22%), Positives = 307/727 (42%), Gaps = 68/727 (9%)
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
IK L+K + +E+ + E ++E L+K K+ + L +L +V+A
Sbjct: 838 IKPLLKSAETEKEM-ATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 896
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQ---RMEQANKKCEEARQEKEAMVMKYVRGEKESLDL 325
+D L A+ QL K Q ++++ N++ E+ + + K + E E +L
Sbjct: 897 QDNLN----DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952
Query: 326 RKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDI 385
+K+ + LE L KE NK+K L++E L ++ E L + +D+
Sbjct: 953 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL 1012
Query: 386 NSHVIKV---KWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMI---- 438
KV ++ KL+ ++D + + ++ K+ L +AK + + K Q+ I
Sbjct: 1013 QVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLE 1072
Query: 439 -KTYQESEEIKSNELDAKLRVTKGELEK----QMQEKSDQLEMHHAKIKELEDLKRTFKE 493
Q E++K E D + +K E E+ Q+Q+K L+ + A+I+ELE E
Sbjct: 1073 NDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKK---LKENQARIEELE-------E 1122
Query: 494 GMDELRTLRTKVKCLEDERLRTEDELSK-----------YKEIINRQKAEIQNLLDKVKT 542
++ RT R KV+ L + R +E+S+ E+ +++AE Q + ++
Sbjct: 1123 ELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1182
Query: 543 ADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQL 602
A E + + + V L I++LQ+ + K +SE L + +TS Q+
Sbjct: 1183 ATLQHEATAAALR--KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1240
Query: 603 QSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACR 662
+L +KVS L+ Q + + + R L + ++ ++QT ELA +
Sbjct: 1241 IKAKANL----EKVS---RTLEDQANEYR-VKLEEAQRSLNDFTTQRAKLQTENGELARQ 1292
Query: 663 QTEVKALSTQVEELK-------DELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDK 715
E +AL +Q+ K ++L Q + + L LQ AR D + Y++
Sbjct: 1293 LEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLRE-QYEE 1351
Query: 716 EVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARK 775
E + N+ A+ R+ T + + + K L +R+ ++A
Sbjct: 1352 ETEAKAELQRVLSKANS-EVAQWRTKYETDAIQRTEELEEA-KKKLAQRLQDAEEAVEAV 1409
Query: 776 NEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKV---HLSRRGGIMA 832
N K +E +L EI + ++ + L + +F+K+ + +
Sbjct: 1410 NAKCSSLEKTKHRLQNEI--EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1467
Query: 833 SLYTSHPADNGLTLELSLEINRKLQAV--LEDTLLKNITLKENLQTLGTEIERLIKHQHE 890
L +S L+ EL N +++ LE +N L+E + L ++ K+ HE
Sbjct: 1468 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHE 1527
Query: 891 LEQRTKK 897
LE+ K+
Sbjct: 1528 LEKVRKQ 1534
Score = 103 bits (257), Expect = 7e-22
Identities = 149/669 (22%), Positives = 272/669 (40%), Gaps = 96/669 (14%)
Query: 113 QKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLS 172
Q+V Q L + +S E + + E + +S+ A+E ++ E++
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL 1272
Query: 173 TEFAEHRVPNGMNKGEHALVLFEKCV--------QDKYLQQEHIIKKLIKENKKHQELFV 224
+F R GE A L EK + Y QQ +K+ ++E K +
Sbjct: 1273 NDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALA 1332
Query: 225 DICSEK----DNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAK 280
D LRE+ ++ TE + + + + S + + + + Q + AK
Sbjct: 1333 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1392
Query: 281 NAVQQLHKEMAQRMEQANKKCEEARQEK-------EAMVMKYVRGEKESLDLRKEKETLE 333
+ Q ++ + +E N KC + K E +++ R + L K++ +
Sbjct: 1393 KKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1452
Query: 334 K-------KLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDIN 386
K K ++ ELE + + + LS E +L YE RE L+E+I
Sbjct: 1453 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEI- 1511
Query: 387 SHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEE 446
S + + K E++ + + +L+ +L A EEA+ E EE
Sbjct: 1512 SDLTEQLGEGGKNVHELE---KVRKQLEVEKLELQSALEEAE-----------ASLEHEE 1557
Query: 447 IKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRT--LRTK 504
K + K E+E+++ EK +++E + + D +T + R LR K
Sbjct: 1558 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVK 1617
Query: 505 VKCLEDERLRTEDELSKYKEII---NRQKAEIQNLL--------DKVKTADQLQEQLQRG 553
K +E + E +LS + +Q +Q+LL D V+ D L+E +
Sbjct: 1618 KK-MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1676
Query: 554 KQEIENLKEEVESLNSLINDLQKDIEGSRK-RESELLLFTERLTSKNAQLQSESNSLQSQ 612
++ L+ E+E L +++ + E SRK E EL+ +ER+ L S++ SL +Q
Sbjct: 1677 ERRNNLLQAELEELRAVV----EQTERSRKLAEQELIETSERV----QLLHSQNTSLINQ 1728
Query: 613 FDKVSCSESQLQSQCEQMKQTNINLESRLLK--------EEELRKEE------------- 651
K+ +QLQS+ E+ Q N E + K EEL+KE+
Sbjct: 1729 KKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1788
Query: 652 VQTL-----------QAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQ 700
QT+ Q L + +++ L +V EL+ EL +++++A S+K + K ++
Sbjct: 1789 EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERR 1848
Query: 701 ARRKLDQVE 709
+ Q E
Sbjct: 1849 IKELTYQTE 1857
Score = 84.3 bits (207), Expect = 5e-16
Identities = 118/563 (20%), Positives = 245/563 (43%), Gaps = 64/563 (11%)
Query: 144 DCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEK-----CV 198
+ KK +++ +E+ +E + ++ S E +HR+ N + E +V E+
Sbjct: 1390 EAKKKLAQRLQD---AEEAVEAVNAKCSSLEKTKHRLQNEI---EDLMVDVERSNAAAAA 1443
Query: 199 QDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLRE------ELKKRTETEKQHMNTIK 252
DK +Q + K L + +K++E ++ S + R +LK E +H+ T K
Sbjct: 1444 LDK--KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1501
Query: 253 QLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMV 312
+ ++E E+ +QL + + ++++ K++ + EEA E
Sbjct: 1502 RENKNLQE---EISDLTEQL-GEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEE 1557
Query: 313 MKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETT 372
K +R + L+ + K +E+KL + ++E+E+ +++ L + +
Sbjct: 1558 GKILRAQ---LEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDS---LQTSLDAETRSRN 1611
Query: 373 RLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSH-KETKDKLKETTTKLTQAKEEADQIR 431
++R K++ D+N I++ A N++ AE K + LK+T +L A D ++
Sbjct: 1612 EVLRVKKKMEGDLNEMEIQLSHA-NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLK 1670
Query: 432 KNCQDMIKTYQESEEIKSNELDAKLRVTKGE---LEKQMQEKSDQLEMHHAKI------- 481
+N +++ + + EL A + T+ E+++ E S+++++ H++
Sbjct: 1671 ENIA-IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1729
Query: 482 ----KELEDLKRTFKEGMDELRTLRTKVK------CLEDERLRTEDELSKYKEIINRQKA 531
+L L+ +E + E R K K + E L+ E + S + E + +
Sbjct: 1730 KKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1789
Query: 532 E-IQNLLDKVKTADQL-----QEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRE 585
+ I++L ++ A+Q+ ++QLQ+ + + L+ E+E+ + K + S +R
Sbjct: 1790 QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRI 1849
Query: 586 SELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEE 645
EL TE +LQ + LQ KV + Q + E +Q N NL +
Sbjct: 1850 KELTYQTEEDKKNLLRLQDLVDKLQL---KVKAYKRQAE---EAEEQANTNLSKFRKVQH 1903
Query: 646 ELRKEEVQTLQAELACRQTEVKA 668
EL + E + AE + K+
Sbjct: 1904 ELDEAEERADIAESQVNKLRAKS 1926
Score = 65.5 bits (158), Expect = 2e-10
Identities = 77/429 (17%), Positives = 194/429 (45%), Gaps = 25/429 (5%)
Query: 143 TDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKY 202
+D T++ K+V E + +++E E L + A + E ++ + ++
Sbjct: 1512 SDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQ--LEFNQ 1569
Query: 203 LQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELN 262
++ E I +KL +++++ ++ + D+L+ L T + + + K++E + E+
Sbjct: 1570 IKAE-IERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME 1628
Query: 263 KEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKES 322
++ + +++ A+ ++Q L K+ +++ A + ++ ++ + + + E
Sbjct: 1629 IQLSHA-NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAEL 1687
Query: 323 LDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLK 382
+LR E E+ + A +EL + + +++ L + L + E + T+L E+++
Sbjct: 1688 EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAV 1747
Query: 383 EDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQ 442
++ + K K A + K+ +D T+ L + K+ +Q K+ Q +
Sbjct: 1748 QECRNAEEKAKKAITDAAMMAEELKKEQD----TSAHLERMKKNMEQTIKDLQHRL---D 1800
Query: 443 ESEEI-------KSNELDAKLRVTKGELEKQMQEKSDQ---LEMHHAKIKEL----EDLK 488
E+E+I + +L+A++R +GELE + + ++ + +IKEL E+ K
Sbjct: 1801 EAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDK 1860
Query: 489 RTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQE 548
+ D + L+ KVK + + E++ + + + E+ ++ A+
Sbjct: 1861 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVN 1920
Query: 549 QLQRGKQEI 557
+L+ ++I
Sbjct: 1921 KLRAKSRDI 1929
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 117 bits (293), Expect = 5e-26
Identities = 129/642 (20%), Positives = 299/642 (46%), Gaps = 83/642 (12%)
Query: 107 KTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEI 166
KT E EQ+ +++ EL + +S + D +S+ K + +EE+
Sbjct: 1264 KTKEEEQQ--RLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQ--IEEL 1319
Query: 167 ESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENK-------KH 219
+ +L A+ + + + H L + +++ + + + + K N K+
Sbjct: 1320 KRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKY 1379
Query: 220 QELFVDICSEKDNLREELKKRTETEKQHMNTI-----------KQLESRIEELNKEVKAS 268
+ + E + +++L +R + ++H+ + ++L++ +E+L +V+ S
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERS 1439
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAM---VMKYVRGEKESLD- 324
IA D +N + L E Q+ E+ + E +++E ++ + K +ESLD
Sbjct: 1440 NAACIALDKKQRNFDKVL-AEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDH 1498
Query: 325 ---LRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKL 381
L++E + L++++ D +++ + I +L + K +L +E E +T+ + E +
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLD--HEKSELQTS--LEEAEAS 1554
Query: 382 KEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTY 441
E +++++ N++K+E+D K+ + EE DQ+++N ++++
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEIDR-------------KIAEKDEELDQLKRNHLRVVESM 1601
Query: 442 QESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTL 501
Q + + + + LR+ K ++E + E +++++HA ++ + LR L
Sbjct: 1602 QSTLDAEIRSRNDALRIKK-KMEGDLNEM--EIQLNHAN-----------RQAAEALRNL 1647
Query: 502 RTKVKCLEDERL------RTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQR-GK 554
R L+D +L R +D+L + ++ R+ +Q +++++ + + E+ ++ +
Sbjct: 1648 RNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAE 1707
Query: 555 QEIENLKEEVESLN----SLIND---LQKDIEGSRKRESELLLFTERLTSKNAQLQSESN 607
QE+ + E V+ L+ SLIN L+ DI + +++ K + +++
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAA 1767
Query: 608 SLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELR----KEEVQTLQAELACRQ 663
+ + K + + L+ + M+QT +L+ RL + E+L K+++Q L+A + R+
Sbjct: 1768 MMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV--RE 1825
Query: 664 TEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKL 705
E + S Q + E V RKH +K+LT Q ++ R+ +
Sbjct: 1826 LESEVESEQKHNV--EAVKGLRKHERRVKELTYQTEEDRKNI 1865
Score = 110 bits (276), Expect = 4e-24
Identities = 155/736 (21%), Positives = 307/736 (41%), Gaps = 70/736 (9%)
Query: 81 AKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESP 140
A+T+ N ++ AK +K E E+K+ ++ E A +++
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAE 906
Query: 141 YDTDCTKK----FISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEK 196
D K +KIK V+ + EEI +EL + + + + K L L
Sbjct: 907 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 966
Query: 197 CVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLES 256
V+ + E+ +K L +E E + EK L+E H T+ L+
Sbjct: 967 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA----------HQQTLDDLQM 1016
Query: 257 RIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYV 316
+++N KA K ++Q ++ +EQ K C + + K +
Sbjct: 1017 EEDKVNTLTKA------------KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLK 1064
Query: 317 RGEKESLDLRKEKETLEKKLRDANKELEKNTNKI-----------KQLSQEKGRLHQLYE 365
++ ++D +K+ L +KL+ E+ KI K++ + + R+ +L E
Sbjct: 1065 LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEE 1124
Query: 366 TKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKE 425
E E + +K + D++ + ++ + + E K + K+ + E
Sbjct: 1125 EIEAERASRAK-AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 426 EAD-QIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKEL 484
E+ Q + K + +S ++D+ RV K +LEK+ E ++ + ++ +
Sbjct: 1184 ESTLQHEATAAALRKKHADSVAELGEQIDSLQRV-KQKLEKEKSELKMEINDLASNMETV 1242
Query: 485 EDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTAD 544
K F++ L +++K E+E+ R +ELS K ++ + E LD+ D
Sbjct: 1243 SKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE---KD 1299
Query: 545 QLQEQLQRGK----QEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNA 600
+ QL RGK Q+IE LK ++E + L ++ +R L E A
Sbjct: 1300 AMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA 1359
Query: 601 QLQ---SESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQA 657
+LQ S++NS +Q+ + E+ + E++++ L RL E E V+ + +
Sbjct: 1360 ELQRGMSKANSEVAQWR--TKYETDAIQRTEELEEAKKKLAQRLQDAE----EHVEAVNS 1413
Query: 658 ELACRQTEVKALSTQVEELKDELVTQRRKHASSI------KDLTKQLQQARRKLDQVESG 711
+ A + + L +VE+L ++ R +A+ I ++ K L + ++K ++ ++
Sbjct: 1414 KCASLEKTKQRLQNEVEDL---MIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQA- 1469
Query: 712 SYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKA 771
+ E S SRS S+ +++ E+ S ++ + + Q + + L E+I K
Sbjct: 1470 --ELEASQKESRSLSTELFKVKNAYEE-SLDHLETLKRENKNLQQEISDLTEQIAEGGK- 1525
Query: 772 HARKNEKIEFMEDHIK 787
H + EK++ DH K
Sbjct: 1526 HIHELEKVKKQLDHEK 1541
Score = 108 bits (269), Expect = 3e-23
Identities = 146/715 (20%), Positives = 307/715 (42%), Gaps = 75/715 (10%)
Query: 237 LKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVT---AKNAVQQLHKEMAQR 293
L K ETEK+ N ++ E EEL K +A R +L + VT KN +Q + A
Sbjct: 843 LLKSAETEKEMANMKEEFEKTKEELAK-TEAKRKELEEKMVTLMQEKNDLQLQVQAEADA 901
Query: 294 MEQANKKCEEARQEK---EAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKI 350
+ A ++C++ + K EA + + ++ ++ E ++KL D EL+K+ I
Sbjct: 902 LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD---I 958
Query: 351 KQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETK 410
L ++ + E + L E+ L E I + K Q + +D + +
Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEE 1018
Query: 411 DKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGEL------E 464
DK+ T T+ +++ D + + + K + E K +L+ L++ + +
Sbjct: 1019 DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAK-RKLEGDLKLAQESTMDTENDK 1077
Query: 465 KQMQEKSDQLEMHHAKIK-ELEDLKRTFKEGMDELRTLRTKVKCLEDE---RLRTEDELS 520
+Q+ EK + E + ++ ++ED + + +++ L+ +++ LE+E + +
Sbjct: 1078 QQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 521 KYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQ-EIENLKEEVESLNSLINDLQKDIE 579
K + ++R+ EI L++ A Q ++ + ++ E + ++ ++E + LQ +
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE-----STLQHEAT 1192
Query: 580 GS--RKRESE-----------LLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQ 626
+ RK+ ++ L ++L + ++L+ E N L S + VS +++ +
Sbjct: 1193 AAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKM 1252
Query: 627 CEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQ--R 684
C ++ + S + +EE ++ + L A+ A TE S Q++E KD +V+Q R
Sbjct: 1253 CRTLE----DQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE-KDAMVSQLSR 1307
Query: 685 RKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENT 744
K A T+Q+++ +R+L++ E+ + ++ S L + E +
Sbjct: 1308 GKQA-----FTQQIEELKRQLEE-ETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAEL 1361
Query: 745 GSSVAVDNFPQVD-----KAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKI 799
++ N + I+R L++A + ++++ E+H++ + + K
Sbjct: 1362 QRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKT 1421
Query: 800 IQSYILREESGTLSSEASDFNKVHLSRR---------------GGIMASLYTSHPADNGL 844
Q E + E S+ + L ++ A L S L
Sbjct: 1422 KQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSL 1481
Query: 845 TLELSLEINRKLQAV--LEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
+ EL N +++ LE +N L++ + L +I KH HELE+ K+
Sbjct: 1482 STELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQ 1536
Score = 91.3 bits (225), Expect = 4e-18
Identities = 129/619 (20%), Positives = 263/619 (42%), Gaps = 105/619 (16%)
Query: 283 VQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKE 342
++ L K E AN K EE + KE + + E + +L ++ TL ++ D +
Sbjct: 840 IKPLLKSAETEKEMANMK-EEFEKTKEELA----KTEAKRKELEEKMVTLMQEKNDLQLQ 894
Query: 343 LEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAE 402
++ + L+ + R QL +TK + I+E+ + ED ++ + KL+ E
Sbjct: 895 VQAEADA---LADAEERCDQLIKTKI-QLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950
Query: 403 MDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGE 462
K+ D L+ T K+ + K + KN + E +E AKL K
Sbjct: 951 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTE--------EMAGLDETIAKLTKEKKA 1002
Query: 463 LEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVK--CLEDERLRTEDELS 520
L++ Q+ D L+M K+ L K ++ +D+L + K C++ ER +
Sbjct: 1003 LQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAK------ 1056
Query: 521 KYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEG 580
+++ K ++ +D QL E+L++ + E+ NL+ ++E +L LQK I+
Sbjct: 1057 --RKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKE 1114
Query: 581 SRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESR 640
+ R EL E + A+ + + + L + +++S E++++ S
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS----------ERLEEAG-GATSA 1163
Query: 641 LLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQ--- 697
++ + R+ E Q ++ +L + +A + + R+KHA S+ +L +Q
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEESTLQHEATAAAL----------RKKHADSVAELGEQIDS 1213
Query: 698 LQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVD 757
LQ+ ++KL++ E E++ + S +
Sbjct: 1214 LQRVKQKLEK-EKSELKMEINDLASNMET------------------------------- 1241
Query: 758 KAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEAS 817
+ KA A + +ED + ++ + ++ ++I L + L +E+
Sbjct: 1242 ----------VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINE--LSAQKARLHTESG 1289
Query: 818 DFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTL 877
+F++ L + +++ L A T ++ E+ R+L+ E+T K+ TL LQ+
Sbjct: 1290 EFSR-QLDEKDAMVSQLSRGKQA---FTQQIE-ELKRQLE---EETKAKS-TLAHALQSA 1340
Query: 878 GTEIERLIKHQHELEQRTK 896
+ + L++ Q+E EQ K
Sbjct: 1341 RHDCD-LLREQYEEEQEAK 1358
Score = 60.8 bits (146), Expect = 5e-09
Identities = 112/595 (18%), Positives = 249/595 (41%), Gaps = 91/595 (15%)
Query: 16 VGKTPELKEDSCNLFSGNESSKLENE---SKLLSLNTDKTLCQPNEHNNRIEAQENYIPD 72
+ +T EL+E L + ++ E SK SL K Q + I+ + +
Sbjct: 1384 IQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERS---- 1439
Query: 73 HGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESAN 132
+C D N +++ A+ K ET+ ++ E RS +
Sbjct: 1440 ----NAACIALDKKQRNFDKV-------LAEWKQKYEETQAELEASQKESRSLSTELFKV 1488
Query: 133 EKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAE-----HRVPNGMNKG 187
+ Y ES + K+ +++L +EI L+ + AE H + +
Sbjct: 1489 KNAYEESLDHLETLKR---------ENKNLQQEISD--LTEQIAEGGKHIHELEKVKKQL 1537
Query: 188 EHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDI---CSEKDNLREELKKRTETE 244
+H + +++ EH K+++ + ++ +I +EKD ++LK+
Sbjct: 1538 DHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKR----- 1592
Query: 245 KQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEA 304
N ++ +ES L+ E+++ D L K ++ EM ++ AN++ EA
Sbjct: 1593 ----NHLRVVESMQSTLDAEIRSRNDAL-----RIKKKMEGDLNEMEIQLNHANRQAAEA 1643
Query: 305 RQ----------EKEAMVMKYVRGE---KESLDLRKEKETL-EKKLRDANKELEKNTNKI 350
+ + + + +RG+ KE L + + + L + ++ + LE+
Sbjct: 1644 LRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGR 1703
Query: 351 KQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETK 410
K QE + + + T LI KL+ DI+ Q +++ + + +
Sbjct: 1704 KMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQ-------IQGEMEDIVQEARNAE 1756
Query: 411 DKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEK 470
+K K+ +T A A++++K + + ++ D +LR+ + E + ++
Sbjct: 1757 EKAKKA---ITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE-QLALKGG 1812
Query: 471 SDQLEMHHAKIKELE-DLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQ 529
Q++ A+++ELE +++ K ++ ++ LR + +++ +TE++ K I+
Sbjct: 1813 KKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDR---KNILR-- 1867
Query: 530 KAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKR 584
+Q+L+DK LQ +++ K++ E +E+ + LQ ++E +++R
Sbjct: 1868 ---LQDLVDK------LQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKER 1913
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 117 bits (292), Expect = 6e-26
Identities = 169/816 (20%), Positives = 345/816 (42%), Gaps = 138/816 (16%)
Query: 7 IASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPN---EHNNRI 63
+ S ++K + E + + + + +E+ + E E KL++L +K Q E N +
Sbjct: 841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLL 900
Query: 64 EAQEN---YIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILV 120
+A+E I E + +E+ E+I + K + +E ++ + + +
Sbjct: 901 DAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 121 ELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRV 180
L + A E + + I+K+ + + L+E + L AE
Sbjct: 961 TLAKVEKEKHATENKVKNLTEELSGLDETIAKL---TREKKALQEAHQQALDDLQAEEDK 1017
Query: 181 PNGMNKGEHALVLFEKCVQD--KYLQQEHIIKKLIKENKKH--------QELFVDICSEK 230
N +NK + L E+ V+D L+QE ++ ++ NK+ QE +D+ ++K
Sbjct: 1018 VNSLNKTKSKL---EQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Query: 231 DNLREELKKR----------TETEK----QHMNTIKQLESRIEELNKEVKASRDQLIAQD 276
L E LKK+ E E+ Q IK+L++RIEEL +E++A R +
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 277 VTAKNAVQQLHKEMAQRMEQA----------NKK-----------CEEARQEKEAMVMKY 315
+ ++L +E+++R+E+A NKK EEA + EAMV
Sbjct: 1135 KQRSDYAREL-EELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAAL 1193
Query: 316 VRGEKESL--------DLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETK 367
+ +S+ +L++ K+ LEK+ + E++ ++ ++ +S+ K L ++ T
Sbjct: 1194 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTL 1253
Query: 368 EGETTRLI---REIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAK 424
E + + EI + ++ + +++ +L +++ + +L + TQ
Sbjct: 1254 EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQT 1313
Query: 425 EEADQ------------------IRKNCQDMIKTYQESEEIKSN---------------- 450
EE + R +C + + Y+E +E K+
Sbjct: 1314 EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWR 1373
Query: 451 ---ELDA-----KLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLR 502
E DA +L K +L +++Q+ +Q+E +AK LE K+ + +++L
Sbjct: 1374 TKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDV 1433
Query: 503 TKVKCLE---DERLRTEDE-LSKYKEIINRQKAEIQNLLDKVKTAD----QLQEQLQRGK 554
+ L D++ R D+ L+++K +AE++ L + ++ +L+ +
Sbjct: 1434 ERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEAL 1493
Query: 555 QEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFD 614
++E +K E ++L I DL + I + K EL +++ + A +Q
Sbjct: 1494 DQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ----------- 1542
Query: 615 KVSCSESQLQSQCEQMKQTNINLESRLLKEEELRK-----EEVQTLQAEL-ACRQTEVKA 668
++ E++ + E+ K I LE +K E RK EE++ L+ +T A
Sbjct: 1543 -LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSA 1601
Query: 669 LSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRK 704
L +V ++E + ++K + ++ QL A R+
Sbjct: 1602 LDAEVRS-RNEAIRLKKKMEGDLNEIEIQLSHANRQ 1636
Score = 108 bits (269), Expect = 3e-23
Identities = 125/634 (19%), Positives = 287/634 (45%), Gaps = 66/634 (10%)
Query: 109 NETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKI-KSVSASEDLLEEIE 167
+E K +I L T +S + E + + +S++ +S A EE++
Sbjct: 1258 SEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELK 1317
Query: 168 SELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENK-------KHQ 220
+L A++ + + + H L + +++ + + + L K N K++
Sbjct: 1318 RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE 1377
Query: 221 ELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAK 280
+ E + +++L +R + ++ + + + +E+ + ++ + L+ A
Sbjct: 1378 TDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAN 1437
Query: 281 NAVQQLHKEMA---QRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLR 337
+ L K+ + + + KCEE++ E EA + KES L E L+
Sbjct: 1438 SLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL-------KESRSLSTELFKLKNAYE 1490
Query: 338 DANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQN 397
+A +LE + K L QE L + + E + I E++K ++ I ++ A
Sbjct: 1491 EALDQLETVKRENKNLEQEIADLTE----QIAENGKTIHELEKSRKQIELEKADIQLALE 1546
Query: 398 KLKAEMDSHKETKDKLKETTTKLTQAKEEAD----QIRKNCQDMIKTYQESEEIKSNELD 453
+ +A ++ H+E K + +LTQ K E D + + + + + YQ + E + LD
Sbjct: 1547 EAEAALE-HEEAK--ILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603
Query: 454 AKLRVTKG--ELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLE-- 509
A++R L+K+M+ +++E+ +L R E + LR+++ ++K +
Sbjct: 1604 AEVRSRNEAIRLKKKMEGDLNEIEI------QLSHANRQAAETLKHLRSVQGQLKDTQLH 1657
Query: 510 -DERLRTEDELSKYKEIINRQKAEIQNLLDKVK-TADQLQEQLQRGKQEIENLKEEVESL 567
D+ LR +++L + I+ R+ +Q +++++ T +Q + + +QE+ + E V+ L
Sbjct: 1658 LDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLL 1717
Query: 568 NSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQC 627
++ L I +K E++L+ +L S+ ++ + + + K + + +
Sbjct: 1718 HTQNTSL---IHTKKKLETDLM----QLQSEVEDASRDARNAEEKAKKAITDAAMMAEEL 1770
Query: 628 EQMKQTNINLE------SRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELV 681
++ + T+ +LE + +K+ + R +E + Q L + +++ L T++ EL+ EL
Sbjct: 1771 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE--QLALKGGKKQIQKLETRIRELEFELE 1828
Query: 682 TQRRKHASS----------IKDLTKQLQQARRKL 705
+++K+ S +K+LT Q ++ R+ +
Sbjct: 1829 GEQKKNTESVKGLRKYERRVKELTYQSEEDRKNV 1862
Score = 103 bits (258), Expect = 5e-22
Identities = 156/772 (20%), Positives = 317/772 (41%), Gaps = 102/772 (13%)
Query: 209 IKKLIKENKKHQELFV---DICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEV 265
IK L+K + +E+ + KD L + KR E E++ + +++ +L +V
Sbjct: 837 IKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKN----DLQLQV 892
Query: 266 KASRDQLIAQDVTAKNAVQQLHK---EMAQRMEQANKKCEEARQEKEAMVMKYVRGEKES 322
+A + L+ A+ QL K ++ ++++ ++ E+ + + K + E E
Sbjct: 893 QAESENLL----DAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDEC 948
Query: 323 LDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLK 382
+L+K+ + LE L KE NK+K L++E L + E L +
Sbjct: 949 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQAL 1008
Query: 383 EDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQ 442
+D+ + KV + NK K++++ E + E KL + + ++ ++ + +K Q
Sbjct: 1009 DDLQAEEDKVN-SLNKTKSKLEQQVEDLESSLEQEKKL---RVDLERNKRKLEGDLKLAQ 1064
Query: 443 ES---EEIKSNELDAKLRVTKGE---LEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMD 496
ES E +LD +L+ E L+ +++++ KIKEL+ +E ++
Sbjct: 1065 ESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE 1124
Query: 497 ELRTLRTKVKCLEDERLRTEDELSK-----------YKEIINRQKAEIQNL--------- 536
R R K + + R +ELS+ E+ +++AE L
Sbjct: 1125 AERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATL 1184
Query: 537 -------------LDKVKTADQLQEQLQRGKQEIENLKEEVE------------------ 565
D V + + LQR KQ++E K E +
Sbjct: 1185 QHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 1244
Query: 566 SLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQS 625
+L + L+ + +R + E+ LT++ ++LQ+E+ L Q ++ SQL
Sbjct: 1245 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSR 1304
Query: 626 QCEQMKQTNINLESRLLKEEELRKEEVQTLQA---------ELACRQTEVKA-LSTQVEE 675
+ Q L+ +L +E + + LQ+ E + E KA L + +
Sbjct: 1305 SKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
Query: 676 LKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSS 735
E+ R K+ + T++L++A++KL Q S +++V ++ ++ +S R
Sbjct: 1365 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDS-EEQVEAVNAKCASLEKTKQRLQ 1423
Query: 736 AEDR----SPENTGS-SVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLV 790
E E S + A+D + +L E + +++ A ++E + L
Sbjct: 1424 GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA----ELEASLKESRSLS 1479
Query: 791 EEIRK-----KTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLT 845
E+ K + + Q ++ E+ L E +D + ++ G + L S
Sbjct: 1480 TELFKLKNAYEEALDQLETVKRENKNLEQEIADLTE-QIAENGKTIHELEKSRKQIELEK 1538
Query: 846 LELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
++ L + + +A LE K + ++ L + +EI+R I + E ++ K+
Sbjct: 1539 ADIQLAL-EEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR 1589
Score = 83.6 bits (205), Expect = 8e-16
Identities = 117/540 (21%), Positives = 213/540 (39%), Gaps = 90/540 (16%)
Query: 368 EGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEA 427
E E + E K K+++ K K + KL + + + +++ + L A+E
Sbjct: 847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERC 906
Query: 428 DQIRK---NCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKEL 484
DQ+ K + IK E E E++A+L K +LE + E K++
Sbjct: 907 DQLIKAKFQLEAKIKEVTERAE-DEEEINAELTAKKRKLEDECSELK----------KDI 955
Query: 485 EDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTAD 544
+DL+ T + E KVK L +E ++ ++K + Q LD ++ +
Sbjct: 956 DDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Query: 545 QLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIE-GSRKRESELLLFTERLTSKNAQLQ 603
L + K ++E E++ES L+ D+E RK E +L L E + L+
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILD----LE 1071
Query: 604 SESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQ 663
++ L + K QLQS+ E + QTL + Q
Sbjct: 1072 NDKQQLDERLKKKDFEYCQLQSKVE----------------------DEQTLGLQF---Q 1106
Query: 664 TEVKALSTQVEELKDELVTQRRKHASSIK---DLTKQLQQARRKLDQVESGSYDKEVSSM 720
++K L ++EEL++E+ +R A + K D ++L++ +L++
Sbjct: 1107 KKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEA------------ 1154
Query: 721 GSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIE 780
G +S+ LN + AE + + +AM + L+K HA
Sbjct: 1155 GGVTSTQIELNKKREAEFLKLRRDLEEATLQH-----EAM----VAALRKKHA------- 1198
Query: 781 FMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPA 840
D + +L E+I ++ Q L E S+F K+ + M S+ S
Sbjct: 1199 ---DSVAELGEQIDNLQRVKQK---------LEKEKSEF-KLEIDDLSSSMESVSKSKAN 1245
Query: 841 DNGL--TLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKKT 898
+ TLE L R ++ +L + T K LQT E+ R ++ + + + ++
Sbjct: 1246 LEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 1305
Score = 67.8 bits (164), Expect = 4e-11
Identities = 91/456 (19%), Positives = 191/456 (41%), Gaps = 50/456 (10%)
Query: 229 EKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTA-----KNAV 283
E NL +E+ TE ++ TI +LE +++ E++ + QL ++ A + +
Sbjct: 1502 ENKNLEQEIADLTEQIAENGKTIHELEKSRKQI--ELEKADIQLALEEAEAALEHEEAKI 1559
Query: 284 QQLHKEMAQRMEQANKKCEEARQEKEAMVMKY---VRGEKESLD--LRKEKETLEKKLRD 338
++ E+ Q + ++K E +E E + Y V + +LD +R E + K
Sbjct: 1560 LRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLK--- 1616
Query: 339 ANKELEKNTNKIK-QLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQN 397
K++E + N+I+ QLS + ET + +R + +D H+ Q
Sbjct: 1617 --KKMEGDLNEIEIQLSHAN--------RQAAETLKHLRSVQGQLKDTQLHLDDALRGQE 1666
Query: 398 KLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLR 457
LK ++ + + L+ +L E+ ++ RK + + E ++ + + L
Sbjct: 1667 DLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQ-NTSLI 1725
Query: 458 VTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTED 517
TK +LE + + E+ED R + ++ + T + +E + +D
Sbjct: 1726 HTKKKLETDLMQLQS----------EVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD 1775
Query: 518 ELSKYKEIINRQKAEIQNLLDKVKTADQL-----QEQLQRGKQEIENLKEEVESLNSLIN 572
+ + + + +++L ++ A+QL ++Q+Q+ + I L+ E+E
Sbjct: 1776 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNT 1835
Query: 573 DLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQM-K 631
+ ++G RK E + + LT ++ + + LQ DK+ + Q E+ +
Sbjct: 1836 E---SVKGLRKYERRV----KELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADE 1888
Query: 632 QTNINLESRLLKEEELRKEEVQTLQAELACRQTEVK 667
Q N +L + EL + E + AE + K
Sbjct: 1889 QANAHLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
Score = 62.8 bits (151), Expect = 1e-09
Identities = 98/464 (21%), Positives = 200/464 (43%), Gaps = 73/464 (15%)
Query: 167 ESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQD-KYLQQE--HIIKKLIKENKKHQELF 223
ES LSTE + + N E AL E ++ K L+QE + +++ + K EL
Sbjct: 1474 ESRSLSTELFKLK-----NAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL- 1527
Query: 224 VDICSEKDNLREELKKRTETEKQHMN-TIKQLESRIEELNKEVKASRDQLIAQDVTAKNA 282
E+ +K+ E EK + +++ E+ +E ++E K R QL V K+
Sbjct: 1528 -----------EKSRKQIELEKADIQLALEEAEAALE--HEEAKILRIQLELTQV--KSE 1572
Query: 283 VQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKE----TLEKKLRD 338
+ + E + +EQ + + + ++ + VR E++ L+K+ E +E +L
Sbjct: 1573 IDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSH 1632
Query: 339 ANKELEKNTNKIKQLSQE------------KGR--LHQLYETKEGETTRLIREIDKLKED 384
AN++ + ++ + + +G+ L + E L E+++L+
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRAT 1692
Query: 385 INSHVIKVKWAQNKLKAEMDSHKE-------------TKDKLKETTTKLTQAKEEADQIR 431
+ K A+ +L +DS++ TK KL+ +L E+A +
Sbjct: 1693 LEQTERARKLAEQEL---LDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDA 1749
Query: 432 KNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTF 491
+N ++ K + + EL K + T LE+ + ++ ++ E E L
Sbjct: 1750 RNAEEKAKKAITDAAMMAEELK-KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL--AL 1806
Query: 492 KEGMDELRTLRTKVKCLE-----DERLRTEDE--LSKY----KEIINRQKAEIQNLLDKV 540
K G +++ L T+++ LE +++ TE L KY KE+ + + + +N+L
Sbjct: 1807 KGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQ 1866
Query: 541 KTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKR 584
D+LQ +++ K++ E E+ + + Q ++E + +R
Sbjct: 1867 DLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Score = 56.6 bits (135), Expect = 1e-07
Identities = 77/447 (17%), Positives = 192/447 (42%), Gaps = 34/447 (7%)
Query: 144 DCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFE-KCVQDKY 202
D T++ K++ E ++IE E + A + E ++ + + Q K
Sbjct: 1512 DLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVK- 1570
Query: 203 LQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELN 262
I +K+ +++++ ++L + + ++ L + + + K++E + E+
Sbjct: 1571 ---SEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIE 1627
Query: 263 KEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKES 322
++ + Q A+ + +VQ K+ ++ A + E+ +++ + + + E
Sbjct: 1628 IQLSHANRQA-AETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV 1686
Query: 323 LDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLK 382
+LR E E+ + A +EL + +++ L + L + E + +L E++
Sbjct: 1687 EELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAS 1746
Query: 383 EDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQ 442
D + K K A + K+ +D T+ L + K+ +Q K+ Q +
Sbjct: 1747 RDARNAEEKAKKAITDAAMMAEELKKEQD----TSAHLERMKKNLEQTVKDLQHRL---D 1799
Query: 443 ESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLR 502
E+E++ L+ K +++K ++ + +LE ELE ++ E + LR
Sbjct: 1800 EAEQL-------ALKGGKKQIQK-LETRIRELEF------ELEGEQKKNTESVKGLRKYE 1845
Query: 503 TKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQE----QLQRGKQEIE 558
+VK L + + + ++++++ + ++++ + + AD+ + ++ + E+E
Sbjct: 1846 RRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELE 1905
Query: 559 NLKEEVESLNSLINDLQ---KDIEGSR 582
+E + S +N L+ +D SR
Sbjct: 1906 EAEERADIAESQVNKLRAKTRDFTSSR 1932
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 115 bits (288), Expect = 2e-25
Identities = 185/863 (21%), Positives = 357/863 (41%), Gaps = 93/863 (10%)
Query: 103 KHISKTNETEQKVTQILVELRSSTFPESANEK--------TYSESPYDTDCTKKFISKI- 153
K +S+ E E++V L R E K T +++ + T+ + +
Sbjct: 969 KELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLT 1028
Query: 154 KSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLI 213
+ ++A ++ + + E + + A + + E + K L+ E ++ L
Sbjct: 1029 EEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAK----LRLEQQVEDLE 1084
Query: 214 KENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLI 273
++ ++L +D K L +LK E+ +QLE ++++ K+ + S+ L
Sbjct: 1085 CSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKK--KDSELSQLSLR 1142
Query: 274 AQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLE 333
+D Q L +M +++++ + EE +E EA R EK+ + +E E L
Sbjct: 1143 VED------EQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELS 1196
Query: 334 KKLRDANKELEKNTNKIKQLSQEKGRLHQLYE----TKEGETTRLIREIDKLKEDINSHV 389
++L +A ++ E GRL + E E L R+ + ++ V
Sbjct: 1197 ERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQV 1256
Query: 390 IKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQ-ESEEIK 448
++ + KL+ E + D L LT+AK A+++ + +D + + + EE++
Sbjct: 1257 DSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQ 1316
Query: 449 SNELDA-----KLRVTKGELEKQMQEKS---DQLEMHHA-KIKELEDLKRTFKEGMDELR 499
DA +L+ GEL + ++EK QL A + LE+L+R +E
Sbjct: 1317 RQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKS 1376
Query: 500 TLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKT----------ADQLQ-- 547
L V+ L + D L + E +AE+Q LL K AD +Q
Sbjct: 1377 ALAHAVQALRHDC----DLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRT 1432
Query: 548 EQLQRGKQE----IENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQ 603
E+L+ K++ ++ +E VE+ N+ + L+K + ++ L ER TS A L
Sbjct: 1433 EELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALD 1492
Query: 604 SESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLK-----EEELRKEEVQTLQAE 658
+ L+ ++ E ++Q + E ++ + L + L + EE L E ++TL+ E
Sbjct: 1493 KKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL--EALETLKRE 1550
Query: 659 LACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVS 718
Q E+ L+ QV L + + + K +++ ++Q A + + K +
Sbjct: 1551 NKNLQEEISDLTDQV-SLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLR 1609
Query: 719 SMGSRSSSSGSLNARSSAEDRSPEN--TGSSVAVDNFPQVDKAMLIER--IVRLQKAHAR 774
S ++ + + +D N AV++ A R +RL+K
Sbjct: 1610 IQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEG 1669
Query: 775 KNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESG-----TLSSEASDFNKVHLSRRGG 829
+E H + E + T+++Q+ + E++G L++E + + L RR
Sbjct: 1670 DLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQA-LERR-- 1726
Query: 830 IMASLYTSHPADNGLTLELSLEINRKL--QAVLEDTLLKNI-------------TLKENL 874
ASL + + LE E +R+L Q +LE T N+ L+ +L
Sbjct: 1727 --ASLLAAELEELRAALEQG-ERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADL 1783
Query: 875 QTLGTEIERLIKHQHELEQRTKK 897
L E+E + + E E++ KK
Sbjct: 1784 AQLSGEVEEAAQERREAEEKAKK 1806
Score = 97.4 bits (241), Expect = 5e-20
Identities = 118/611 (19%), Positives = 272/611 (44%), Gaps = 81/611 (13%)
Query: 142 DTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDK 201
+ +C +S+ K+++A LEE+ +L A+ + + + H L + +++
Sbjct: 1342 EKECLISQLSRGKALAAQS--LEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEE 1399
Query: 202 YLQQEHIIKKLIKEN-------KKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQL 254
Q + + L K N K++ + E + +++L R + ++ +
Sbjct: 1400 AEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAK 1459
Query: 255 ESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKE---MAQRMEQANKKCEEARQEKEAM 311
S +E+ ++ + + + A +A L K+ + + +E+ ++ EE ++E EA
Sbjct: 1460 CSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAA 1519
Query: 312 ----------VMKYVRGEKESLD----LRKEKETLEKKLRDANKELEKNTNKIKQLSQEK 357
+ + G +E+L+ L++E + L++++ D ++ + I++L + K
Sbjct: 1520 QRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTK 1579
Query: 358 GRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETT 417
L E ++ E + E + E + ++++ +++KAE+D
Sbjct: 1580 KAL----EGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR------------ 1623
Query: 418 TKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMH 477
KL + EE +R+N Q +++ Q S + ++ + LR L+K+M+ + LE+
Sbjct: 1624 -KLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALR-----LKKKMEGDLNDLEL- 1676
Query: 478 HAKIKELEDLKRTFKEGMDELRTLRTKVK---CLEDERLRTEDELSKYKEIINRQKAEIQ 534
+L R E R ++ ++K DE R EL + + + R+ + +
Sbjct: 1677 -----QLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLA 1731
Query: 535 NLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTER 594
L++++ A + E+ +R ++ L E E LN L + + +K E++L +
Sbjct: 1732 AELEELRAALEQGERSRRLAEQ--ELLEATERLNLLHSQNTGLLNQKKKLEADLA----Q 1785
Query: 595 LTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLE------SRLLKEEELR 648
L+ + + E + + K + + + ++ + T+ +LE + ++E + R
Sbjct: 1786 LSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQAR 1845
Query: 649 KEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASS----------IKDLTKQL 698
EE + QA L + +V+ L +V EL+ EL +++KHA + +K+L Q
Sbjct: 1846 LEEAE--QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQA 1903
Query: 699 QQARRKLDQVE 709
++ R+ L +++
Sbjct: 1904 EEDRKNLARMQ 1914
Score = 94.0 bits (232), Expect = 6e-19
Identities = 161/754 (21%), Positives = 304/754 (40%), Gaps = 130/754 (17%)
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELK----KRTETEKQHMNTIKQLESRIEELNKE 264
+K L++ + +EL + +E LR L KR E E+ H++ ++ +L +
Sbjct: 885 MKPLLRSAQAEEELAA-LRAELRGLRGALAAAEAKRQELEETHVSITQEKN----DLALQ 939
Query: 265 VKASRDQLIAQD------VTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRG 318
++A +D L + + +K ++ KE+++R+E EE + A K
Sbjct: 940 LQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDE----EEVNADLAARRRKL--- 992
Query: 319 EKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLH----------------- 361
E E +L+K+ + L+ L A KE + NK+K L++E L
Sbjct: 993 EDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAH 1052
Query: 362 -------QLYETKEGETTRLIREIDKLKEDINSHV-------IKVKWAQNKLKAEMDSHK 407
Q E + T+ +++ ED+ + + + A+ KL+ ++ +
Sbjct: 1053 QQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQ 1112
Query: 408 ET-----------KDKLKETTTKLTQAK---EEADQIRKNCQDMIKTYQESEEIKSNELD 453
E+ ++KLK+ ++L+Q E+ + Q IK Q E EL+
Sbjct: 1113 ESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELE 1172
Query: 454 AKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGM----DELRTLRTKVKCLE 509
A+ R + +EKQ E + +LE +++E +EG EL LR + LE
Sbjct: 1173 AE-RAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRE---LE 1228
Query: 510 DERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQ-LQEQLQRGKQEIENLKEEVESLN 568
+ LR E ++ + AE+ +D ++ Q L+++ + E+++L VE+L
Sbjct: 1229 EAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLT 1288
Query: 569 SLINDLQKDIEGSRKRESELLLFTERL-------TSKNAQLQSESNSLQSQFDKVSCSES 621
+K + SE + E L +++ +LQ+ES L ++ C S
Sbjct: 1289 RAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLIS 1348
Query: 622 QLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQA-----ELACRQTEVKA-----LST 671
QL Q+ L +L +E + + +QA +L Q E +A L
Sbjct: 1349 QLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQR 1408
Query: 672 QVEELKDELVTQRRKHASSIKDLTKQLQQARRKLD-QVESGSYDKEVSSMGSRSSSSGSL 730
+ + E+ R K+ + T++L++A++KL +++ E ++ S L
Sbjct: 1409 LLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKL 1468
Query: 731 NARSSAEDRSPE---NTGSSVAVDNFPQVDKAMLIER----------------------- 764
++ +ED + E T ++ A+D + + L ER
Sbjct: 1469 RLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGT 1528
Query: 765 -IVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVH 823
+ RL+ H E +E ++ K L EEI T + SG E K
Sbjct: 1529 ELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSL------SGKSIQELEKTKKAL 1582
Query: 824 LSRRGGIMASLYTSHPA---DNGLTLELSLEINR 854
+ I A+L + A + TL + LE+++
Sbjct: 1583 EGEKSEIQAALEEAEGALELEETKTLRIQLELSQ 1616
Score = 69.7 bits (169), Expect = 1e-11
Identities = 116/520 (22%), Positives = 223/520 (42%), Gaps = 54/520 (10%)
Query: 399 LKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEE--IKSN-ELDAK 455
L+ + + + + +L+ET +TQ K + + QD + +E IKS +L+ K
Sbjct: 908 LRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGK 967
Query: 456 LRVTKGELEKQMQEKSD------QLEMHHAKIK-ELEDLKRTFKEGMDELRTLRTKVKCL 508
++ LE + + +D +LE ++K +++DLK T + E + KVK L
Sbjct: 968 VKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNL 1027
Query: 509 EDERLRTEDELSKY-KEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESL 567
+E ++ +++ KE Q+A Q L D D++ L + K +E E++E
Sbjct: 1028 TEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRV-SALTKAKLRLEQQVEDLECS 1086
Query: 568 NSLINDLQKDIE-GSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQ 626
L+ D E RK E +L L E + A + L+ + K SQL +
Sbjct: 1087 LEQEKKLRMDTERAKRKLEGDLKLTQESV----ADAAQDKQQLEEKLKKKDSELSQLSLR 1142
Query: 627 CEQMKQTNINLESRLLKEEELRKEEV-QTLQAELACR----------QTEVKALSTQVEE 675
E + ++ + +KE + R EE+ + L+AE A R E++ LS ++EE
Sbjct: 1143 VEDEQLLGAQMQKK-IKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEE 1201
Query: 676 LKDELVTQR---RKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNA 732
QR RK + + L ++L++A + + + K+ SL
Sbjct: 1202 AGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSL-- 1259
Query: 733 RSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEE 792
+ + E + + VD D A +E + R + + + E K VEE
Sbjct: 1260 QRVRQKLEKEKSELRMEVD-----DLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEE 1314
Query: 793 IRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEI 852
++++ + + G L +E+ + +++ L + +++ L L + E+
Sbjct: 1315 LQRQLADAST-----QRGRLQTESGELSRL-LEEKECLISQL----SRGKALAAQSLEEL 1364
Query: 853 NRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELE 892
R+L+ E++ K+ L +Q L + + L++ QHE E
Sbjct: 1365 RRQLE---EESKAKS-ALAHAVQALRHDCD-LLREQHEEE 1399
Score = 63.9 bits (154), Expect = 6e-10
Identities = 106/572 (18%), Positives = 234/572 (40%), Gaps = 98/572 (17%)
Query: 87 SENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFP-ESANEKTYSESPYDTDC 145
S+ + ++A + S A I +T E E+ ++ + L+ + E+AN K C
Sbjct: 1411 SKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAK----------C 1460
Query: 146 TKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQ 205
+ +K++ + SED+ E+E + + K H E+ ++++ Q+
Sbjct: 1461 SSLEKAKLRLQTESEDVTLELERATSAAAALD-------KKQRH----LERALEERRRQE 1509
Query: 206 EHIIKKLIKENKKHQELFVDICS-----------------EKDNLREELKKRTETEKQHM 248
E + ++L ++ + L ++ E NL+EE+ T+
Sbjct: 1510 EEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSG 1569
Query: 249 NTIKQLE----------SRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQAN 298
+I++LE S I+ +E + + + + + + + Q+ E+ +++ + +
Sbjct: 1570 KSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKD 1629
Query: 299 KKCEEARQEKEAMVMKY-------VRGEKESLDLRKEKE----TLEKKLRDANK---ELE 344
++C R+ + V R E+L L+K+ E LE +L A + E +
Sbjct: 1630 EECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQ 1689
Query: 345 KNTNKIK-QLSQEKG----------RLHQLYETKEGETTRLIREIDKLKEDINS------ 387
T ++ QL +E+ LH+ + E + L E+++L+ +
Sbjct: 1690 AATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRR 1749
Query: 388 ----HVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQE 443
+++ N L ++ K KL+ +L+ EEA Q R+ ++ K
Sbjct: 1750 LAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAIT 1809
Query: 444 SEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRT 503
+ + EL K + T LE+ + + A+++E E + + G +++ L
Sbjct: 1810 DAAMMAEELK-KEQDTSAHLERMKKTLEQTVRELQARLEEAE--QAALRGGKKQVQKLEA 1866
Query: 504 KVKCLE---DERLRTEDELSK--------YKEIINRQKAEIQNLLDKVKTADQLQEQLQR 552
KV+ LE D + E K KE+ + + + +NL D+LQ +++
Sbjct: 1867 KVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKS 1926
Query: 553 GKQEIENLKEEVESLNSLINDLQKDIEGSRKR 584
K++ E +++ + + Q +++ + +R
Sbjct: 1927 YKRQFEEAEQQANTNLAKYRKAQHELDDAEER 1958
Score = 39.7 bits (91), Expect = 0.013
Identities = 39/230 (16%), Positives = 96/230 (41%), Gaps = 42/230 (18%)
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
+++ +E ++ +E ++ + EELKK +T LE
Sbjct: 1790 VEEAAQERREAEEKAKKAITDAAMMAEELKKEQDT-------SAHLE------------- 1829
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKE 328
K ++Q +E+ R+E+A + +++ + VR +L E
Sbjct: 1830 ---------RMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVR------ELEAE 1874
Query: 329 KETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSH 388
+ +KK +A K + K+ ++K+L+ + E R+ +DKL+ + S+
Sbjct: 1875 LDAEQKKHAEALKGVRKHERRVKELAYQA-------EEDRKNLARMQDLVDKLQSKVKSY 1927
Query: 389 VIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMI 438
+ + A+ + + +++ + +L + + A+ +A+++R +D +
Sbjct: 1928 KRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTRDAL 1977
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 114 bits (286), Expect = 3e-25
Identities = 190/894 (21%), Positives = 379/894 (42%), Gaps = 126/894 (14%)
Query: 3 ETDHIASTSSDKNVGKTPELKED-----SCNLFSGNESSK----LENESKLLSLNTDKTL 53
E + I + + K +L ED + NL E SK L+N+ + + + ++ L
Sbjct: 977 EEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERL 1036
Query: 54 CQPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQ 113
+ + +E + DS +D +E QIA AK K E +
Sbjct: 1037 RREEKQRQELEKTRRKLEG-----DSTDLSDQIAELQAQIAELKM-QLAK---KEEELQA 1087
Query: 114 KVTQILVELRSSTFPESANEKTYSE-SPYDTDCTKKFISKIKSVSASEDLLEEIESELLS 172
+ ++ E + S+ S D + S+ K+ DL EE+E+ L
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEA--LK 1145
Query: 173 TEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDN 232
TE E + + + E ++ K Q+ +I+KK ++E K E +
Sbjct: 1146 TEL-EDTLDSTAAQQE---------LRSKREQEVNILKKTLEEEAKTHEAQIQ------- 1188
Query: 233 LREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQ 292
E ++H +++L ++E+ K VKA+ ++ AK ++ E+A
Sbjct: 1189 ---------EMRQKHSQAVEELAEQLEQ-TKRVKANLEK-------AKQTLENERGELAN 1231
Query: 293 RME---QANKKCEEARQEKEAMV----MKYVRGEKESLDLRKEKETLEKKLRDANKELEK 345
++ Q E R++ EA + +K+ GE+ +L + L+ +L + L +
Sbjct: 1232 EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 346 NTNKIKQLSQEKGRLH-QLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMD 404
+ +K +L+++ L QL +T+E L++E ++ K +++ + +V+ +N + +++
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQE-----LLQEENRQKLSLSTKLKQVEDEKNSFREQLE 1346
Query: 405 SHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELE 464
+E K L++ L + ++K +D + + +EE+K KL+ L
Sbjct: 1347 EEEEAKHNLEKQIATL---HAQVADMKKKMEDSVGCLETAEEVKR-----KLQKDLEGLS 1398
Query: 465 KQMQEKS---DQLEMHHAKIK-ELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELS 520
++ +EK D+LE +++ EL+DL L K K D+ L E +S
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKF-DQLLAEEKTIS 1457
Query: 521 -KYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKE----EVESLNSLINDLQ 575
KY E +R +AE + K + + E+ K E+E L + E+E L S +D+
Sbjct: 1458 AKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVG 1517
Query: 576 KDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNI 635
K + K + L +++ QL+ + LQ+ D E LQ+ Q ++
Sbjct: 1518 KSVHELEKSKRAL---EQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER--- 1571
Query: 636 NLESRLLKEEELRKE---EVQTLQAEL-----------ACR---QTEVKALSTQVEEL-- 676
+L+ R + EE +K+ +V+ ++AEL A R + ++K L ++
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK 1631
Query: 677 -KDELVTQRRKHASSIKDLTKQLQQARRKLDQV--ESGSYDKEVSSMGS-----RSSSSG 728
+DE + Q RK + +KD ++L R +++ ++ +K++ SM + + +
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691
Query: 729 SLNARSSAE---DRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDH 785
+ A+ A+ D + +S +K L RI +L++ + E + D
Sbjct: 1692 AERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751
Query: 786 IKQL---VEEIRKKTKIIQSYILREESGTLSSEASDFN-KVHLSRRGGIMASLY 835
+K+ +++I + +S+ + E+ E + KV L G + S Y
Sbjct: 1752 LKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKY 1805
Score = 112 bits (279), Expect = 2e-24
Identities = 164/790 (20%), Positives = 350/790 (44%), Gaps = 80/790 (10%)
Query: 150 ISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGE--HALVLFEKCVQDKYLQQEH 207
+ + VS E+ + E EL+ + N + + E + ++ EK + LQ E
Sbjct: 834 VKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 208 IIKKLIKENK-----KHQELFVDICSEKDNLREELKKRTE----TEKQHMNTIKQLESRI 258
+ +E + K QEL +IC + + EE ++R + +K+ I++LE ++
Sbjct: 894 ELCAEAEELRARLTAKKQEL-EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952
Query: 259 EELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRG 318
E E +++R +L + VT + +++L +E +E N K + ++ E + ++
Sbjct: 953 E----EEESARQKLQLEKVTTEAKLKKLEEEQI-ILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 319 ----EKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRL 374
E++S L K K E + D + L + + ++L + + +L EG++T L
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL-------EGDSTDL 1060
Query: 375 IREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNC 434
+I +L+ I +++ + +L+A + +E + K+ + + + +++++
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120
Query: 435 QDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEG 494
+ + ++E+ K +L +L K ELE + + Q E+ + +E+ LK+T +E
Sbjct: 1121 ESERASRNKAEKQK-RDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE- 1178
Query: 495 MDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLL-----DKVKTADQLQEQ 549
E +T +++ + + + +EL++ E R KA ++ ++ + A++++
Sbjct: 1179 --EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVL 1236
Query: 550 LQRGKQEIENLKEEVESLNSLINDLQ-KDIEGSRKRE------SELLLFTERLTSKNAQL 602
LQ GK + E+ +++VE + + +LQ K EG R R ++L + + +T +Q
Sbjct: 1237 LQ-GKGDSEHKRKKVE---AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS 1292
Query: 603 QSESNSLQSQFDKVSCSESQLQSQCEQMKQTN---INLESRLLKEEELRKEEVQTLQAEL 659
S+S+ L F S ESQLQ E +++ N ++L ++L + E+ + + L+ E
Sbjct: 1293 DSKSSKLTKDF---SALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE 1349
Query: 660 ACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSS 719
+ L Q+ L ++ ++K S+ L + ++ +RKL K++
Sbjct: 1350 EAKHN----LEKQIATLHAQVADMKKKMEDSVGCL-ETAEEVKRKL--------QKDLEG 1396
Query: 720 MGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRL--QKAHARKNE 777
+ R + + + + VD Q A +E+ + Q K
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 778 KIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMAS---- 833
++ E+ + E K+TK + EE+ +E NK + +M+S
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV 1516
Query: 834 ------LYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKH 887
L S A E+ ++ +L+ L+ T + L+ NLQ + + ER ++
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQL-EELEDELQATEDAKLRLEVNLQAMKAQFERDLQG 1575
Query: 888 QHELEQRTKK 897
+ E + KK
Sbjct: 1576 RDEQSEEKKK 1585
Score = 111 bits (278), Expect = 3e-24
Identities = 147/685 (21%), Positives = 288/685 (42%), Gaps = 143/685 (20%)
Query: 154 KSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFE----KCVQDKYLQQEHII 209
+++ E+ LEE ES + + + K E ++ E K ++K L ++ I
Sbjct: 943 QNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIA 1002
Query: 210 -------------KKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNT---IKQ 253
K L K KH+ + D+ ++ LR E K+R E EK
Sbjct: 1003 EFTTNLTEEEEKSKSLAKLKNKHEAMITDL---EERLRREEKQRQELEKTRRKLEGDSTD 1059
Query: 254 LESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQR------MEQANKKCEEARQE 307
L +I EL ++ + QL ++ + A+ ++ +E AQ+ + + + E +++
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQED 1119
Query: 308 KEAMVMKYVRGEKESLDLRKEKETLEKKLRD------ANKEL----EKNTNKIKQLSQEK 357
E+ + EK+ DL +E E L+ +L D A +EL E+ N +K+ +E+
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 358 GRLH--QLYETKEG-------------ETTRLIREIDKLKEDINSHVIKVKWAQNKLKAE 402
+ H Q+ E ++ +T R+ ++K K+ + + ++ N++K
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA---NEVKVL 1236
Query: 403 MDSHKETKDKLKETTTKLTQAK---EEADQIRKNCQDMIKTYQ-ESEEI-----KSNELD 453
+ +++ K K+ +L + + E +++R D + Q E + + +S+
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS 1296
Query: 454 AKLRVTKGELEKQMQEKSDQLEMHH-------AKIKELEDLKRTFKEGMDE--------- 497
+KL LE Q+Q+ + L+ + K+K++ED K +F+E ++E
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Query: 498 --LRTLRTKVK-----------CLE--------------------DERLRTEDELSKYKE 524
+ TL +V CLE +E++ D+L K K
Sbjct: 1357 KQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKT 1416
Query: 525 IINR-----------QKAEIQNLLDKVKTADQLQEQL---------QRGKQEIENLKEEV 564
+ + Q+ NL K K DQL + +R + E E ++E
Sbjct: 1417 RLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET 1476
Query: 565 ESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQ 624
++L+ L + +E + ++++EL ++ ++ L S + + ++ S+ L+
Sbjct: 1477 KALS-----LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531
Query: 625 SQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQR 684
Q E+MK LE L E+ + LQA A + +++ Q EE K +LV Q
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQV 1591
Query: 685 RKHASSIKDLTKQLQQ---ARRKLD 706
R+ + ++D KQ AR+KL+
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLE 1616
Score = 87.4 bits (215), Expect = 5e-17
Identities = 101/504 (20%), Positives = 218/504 (43%), Gaps = 93/504 (18%)
Query: 167 ESELLSTEFAEHR---VPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELF 223
E + +S ++AE R K AL L ++ ++Q+ +++L K+ + E
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARAL--EEAMEQKAELERLNKQFRTEME-- 1507
Query: 224 VDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAV 283
D+ S KD++ + + + ++++ ++++++++EEL E++A+ D + +V +
Sbjct: 1508 -DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566
Query: 284 QQLHKEMAQRMEQANKKCE-----------EARQEKEAMVMKYVRGEKESLDLR------ 326
Q +++ R EQ+ +K + E E++ M +K +DL+
Sbjct: 1567 AQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHI 1626
Query: 327 -----------KEKETLEKKLRDANKELE--------------KNTNKIKQLSQEKGRLH 361
K+ L+ +++D +EL+ +N K+K + E +L
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ 1686
Query: 362 QLYETKEGETTRLIREIDKLKEDINSH--------------VIKVKWAQNKLKAEMDSHK 407
+ E + +E D+L ++I + ++ + +L+ E + +
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTE 1746
Query: 408 ETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQM 467
D+LK+ ++ Q + + R + Q Q+ E ++ EL KL+ +G ++ +
Sbjct: 1747 LINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER-QNKELKVKLQEMEGTVKSKY 1805
Query: 468 QEKSDQLEMHHAKIKELED-LKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEII 526
+ LE AKI +LE+ L KE + +R K L+D L+ +DE
Sbjct: 1806 KASITALE---AKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE-------- 1854
Query: 527 NRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRES 586
R + ++ DK T +L++ K+++E +EE + N+ LQ+++E +
Sbjct: 1855 RRNAEQYKDQADKAST------RLKQLKRQLEEAEEEAQRANASRRKLQRELEDA----- 1903
Query: 587 ELLLFTERLTSKNAQLQSESNSLQ 610
TE + N ++ S N L+
Sbjct: 1904 -----TETADAMNREVSSLKNKLR 1922
Score = 53.9 bits (128), Expect = 7e-07
Identities = 92/414 (22%), Positives = 175/414 (42%), Gaps = 49/414 (11%)
Query: 501 LRTKVKCLEDERLRTEDELSKYKEIINRQKAEI--QNLLDKVKTADQLQEQLQRGKQEIE 558
L TKVK L + E+ ++K +E++ ++ ++ +N L +++T LQ QL K +
Sbjct: 830 LFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMET---LQSQLMAEKLQ-- 884
Query: 559 NLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSC 618
LQ+ ++ + +E RLT+K +L+ + L+++ ++
Sbjct: 885 ---------------LQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEE 929
Query: 619 SESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKD 678
LQ++ ++M+Q LE +L +EE R Q LQ E + ++K L + L+D
Sbjct: 930 RCQHLQAEKKKMQQNIQELEEQLEEEESAR----QKLQLEKVTTEAKLKKLEEEQIILED 985
Query: 679 E---LVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSS 735
+ L +++ I + T L + K S S K + + + R
Sbjct: 986 QNCKLAKEKKLLEDRIAEFTTNLTEEEEK-----SKSLAKLKNKHEAMITDLEERLRREE 1040
Query: 736 AEDRSPENTGSSVAVDNFPQVDK-AMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEE-- 792
+ + E T + D+ D+ A L +I L+ A+K E+++ +++ +
Sbjct: 1041 KQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKN 1100
Query: 793 -IRKKTKIIQSYILREESGTLSSEASDFNKVHLSRR--GGIMASLYT-------SHPADN 842
KK + ++S I E L SE + NK +R G + +L T S A
Sbjct: 1101 MALKKIRELESQI-SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ 1159
Query: 843 GLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTK 896
L + E+N + + E+ ++E Q +E L + Q E +R K
Sbjct: 1160 ELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE-QLEQTKRVK 1212
Score = 41.2 bits (95), Expect = 0.004
Identities = 49/206 (23%), Positives = 94/206 (45%), Gaps = 31/206 (15%)
Query: 162 LLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIK------KLIKE 215
L EE+E E +TE R+ + A + ++ D L++ H K +L ++
Sbjct: 1734 LEEELEEEQGNTELINDRL-------KKANLQIDQINTDLNLERSHAQKNENARQQLERQ 1786
Query: 216 NK----KHQELFVDICSE-KDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRD 270
NK K QE+ + S+ K ++ K + E+Q N K+ ++ +++ + K +D
Sbjct: 1787 NKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKD 1846
Query: 271 QLIAQDVTAKNAVQQLHKEMAQ----RMEQANKKCEEARQEKEAMVMKYVRGEKESLDLR 326
L+ D +NA Q +K+ A R++Q ++ EEA +E + R L+
Sbjct: 1847 VLLQVDDERRNAEQ--YKDQADKASTRLKQLKRQLEEAEEEAQ-------RANASRRKLQ 1897
Query: 327 KEKETLEKKLRDANKELEKNTNKIKQ 352
+E E + N+E+ NK+++
Sbjct: 1898 RELEDATETADAMNREVSSLKNKLRR 1923
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 114 bits (286), Expect = 3e-25
Identities = 152/727 (20%), Positives = 315/727 (43%), Gaps = 67/727 (9%)
Query: 196 KCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREE---LKKRTETEKQ-HMNTI 251
K +QDK + E + + +E K+ E ++ ++N EE LK + ETE TI
Sbjct: 1318 KTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTI 1377
Query: 252 KQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAM 311
QL + EE +A D L ++ + +++L + Q E + E+ +Q+K
Sbjct: 1378 HQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATG 1437
Query: 312 VMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGET 371
R ++ ++LR+ + ++ + L+ I+ ++E RL QL + + +
Sbjct: 1438 SEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR 1497
Query: 372 TRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAK---EEAD 428
K ED N+ + +V++ K + S ET +KLK +LT+ + E
Sbjct: 1498 --------KCLEDENARLQRVQYDLQKANS---SATETINKLKVQEQELTRLRIDYERVS 1546
Query: 429 QIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLK 488
Q R I +Q S EL + + + EL + + S+ +ELE ++
Sbjct: 1547 QERTVKDQDITRFQNS----LKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMR 1602
Query: 489 RTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIIN---RQKAEIQNLLDKVKT-AD 544
R+ KE ++ L +++ + R+ED+L + +++++ R+K Q L ++ + +
Sbjct: 1603 RSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVE 1662
Query: 545 QLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQS 604
L+ QL + ++ ++ E I D + + S+ L TE LT ++ L+
Sbjct: 1663 ALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEE 1722
Query: 605 ESNSLQSQFDKVSCSES-----------QLQSQCEQMKQTNINLESRLLKEEELRKEEVQ 653
E +L+ ++D + S +L+SQ + + L+ + +L++E +
Sbjct: 1723 ELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLI---NDLQRER-E 1778
Query: 654 TLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSY 713
L+ E+ Q + S +++E K++ TQ + S+ K L+Q + +L ++E
Sbjct: 1779 NLRQEIEKFQKQALEASNRIQESKNQ-CTQVVQERESLLVKIKVLEQDKARLQRLED--- 1834
Query: 714 DKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHA 773
E++ S + + R E + +N + + + IE +K+
Sbjct: 1835 --ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIES--EREKSER 1890
Query: 774 RKN---EKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNK--------- 821
KN +IE ++ IK++ E R+K + RE L +E S + +
Sbjct: 1891 EKNSLRSEIERLQAEIKRIEERCRRKLE----DSTRETQSQLETERSRYQREIDKLRQRP 1946
Query: 822 --VHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGT 879
H + ++ TS +GL +++ + Q + + TL K + K++++ + +
Sbjct: 1947 YGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVAS 2006
Query: 880 EIERLIK 886
EI+ ++
Sbjct: 2007 EIQPFLR 2013
Score = 110 bits (275), Expect = 6e-24
Identities = 165/786 (20%), Positives = 335/786 (42%), Gaps = 114/786 (14%)
Query: 195 EKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREE---LKKRTETEKQ-HMNT 250
EK +++K + E + L +E + +E ++ +++ EE L+ + ETE T
Sbjct: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTT 1220
Query: 251 IKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEA 310
IK++ + E+ +K ++ D+L ++ K+ + +L+ + Q EQ + E A Q+K
Sbjct: 1221 IKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKAC 1280
Query: 311 ------------MVMKYVRGEKESLDLRKEKETLE---KKLRDANKELEKNTNKIKQLSQ 355
+ +K V ++ S D + K++LE K ++D NKE+E ++K Q
Sbjct: 1281 GSEIMQKKQHLEIELKQVM-QQRSEDNARHKQSLEEAAKTIQDKNKEIE----RLKAEFQ 1335
Query: 356 EKGRLHQLYETKEGET-TRLIREIDKLKEDINSHVIKVKWAQNKL-----------KAEM 403
E+ + YE + + EI LK + + K ++L +A++
Sbjct: 1336 EEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQI 1395
Query: 404 DS----HKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLR-V 458
D+ ++ +++K LTQ E ++ ++ Q T E + + +L+ +LR V
Sbjct: 1396 DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQ-RKQQLEVELRQV 1454
Query: 459 TKGELEKQMQEK---SDQLEMHHAKIKELEDLKRTF-KEGMDELRTLRTKVKCLEDERLR 514
T+ E+ ++ K D + K KE+E LK+ KE D KCLEDE R
Sbjct: 1455 TQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDR--------KCLEDENAR 1506
Query: 515 ------------------------TEDELSK----YKEIINRQKAEIQNLLDKVKTADQL 546
E EL++ Y+ + + + Q++ + +L
Sbjct: 1507 LQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKEL 1566
Query: 547 QEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLL----FTERLTSKNAQL 602
Q Q Q+ ++E+ LK + L++++EG R+ E + T++L +
Sbjct: 1567 QLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVK 1626
Query: 603 QSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLES---RLLKEEE------LRKEEVQ 653
+ + L+ Q D + + Q E++++ + +E+ +LL+E+E LR E Q
Sbjct: 1627 KRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQ 1686
Query: 654 TLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSY 713
+ + E K +++ L + L + +++L + RR + +S
Sbjct: 1687 KAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADS--- 1743
Query: 714 DKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHA 773
DK + + RS S N R+ E G + N Q ++ L + I + QK
Sbjct: 1744 DKNATILELRSQLQISNN-------RTLELQG----LINDLQRERENLRQEIEKFQKQAL 1792
Query: 774 RKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFN--KVHLSRRGGIM 831
+ +I+ ++ Q+V+E +++ +++ +L ++ L + N K L +
Sbjct: 1793 EASNRIQESKNQCTQVVQE--RESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVK 1850
Query: 832 ASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHEL 891
L + + +RK +A+ + + + +E +L +EIERL +
Sbjct: 1851 QRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK-NSLRSEIERLQAEIKRI 1909
Query: 892 EQRTKK 897
E+R ++
Sbjct: 1910 EERCRR 1915
Score = 82.4 bits (202), Expect = 2e-15
Identities = 133/704 (18%), Positives = 294/704 (41%), Gaps = 99/704 (14%)
Query: 145 CTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQ 204
CT + + ++++ +ED+L+ E+ L E V ++K E +K D L+
Sbjct: 768 CTVRAL--LQAILQTEDMLKVYEARLTE----EETVCLDLDKVEAYRCGLKKIKNDLNLK 821
Query: 205 QEHIIKKLIKENKKHQELFVDICSEKDNLREEL----KKRTETEKQHMNTIKQLESRIEE 260
+ ++ + E +K Q++ + +L +K T+ + KQ++ R+ +
Sbjct: 822 KS-LLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWD 880
Query: 261 LNKEVKASRDQLIAQDVTAK---NAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVR 317
L K++K R+ K +A ++ + + +N ++K + +
Sbjct: 881 LEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKN--LHSEIS 938
Query: 318 GEKE-SLDLRKEKETLEKKLRDANKELEKNTNKIKQLS-----------------QEKGR 359
G+++ S +++K E ++D +L T+ ++ L QE
Sbjct: 939 GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
Query: 360 LHQLYE---TKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKET 416
+H Y T+ G+ R + E+ K ED+ K++ + +L+ D++ E +K K
Sbjct: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL 1058
Query: 417 TTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSN-ELDAKLRVTKGELEKQMQEKSDQLE 475
L + + E Q + + EE+K ELD K L+
Sbjct: 1059 DQNLQKYQAECSQFKAKLASL-------EELKRQAELDGK-------------SAKQNLD 1098
Query: 476 MHHAKIKEL-EDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK----YKEIINRQK 530
+ +IKEL E + R E DE R R V+ D++ D+L K KE + QK
Sbjct: 1099 KCYGQIKELNEKITRLTYEIEDEKRR-RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQK 1157
Query: 531 AEIQNLL-DKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELL 589
E + + +K ++L+ LQ + E+ + + N+ ++ K E+E+
Sbjct: 1158 LESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLR--NKYETEIN 1215
Query: 590 LFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRK 649
+ + + Q + +S +L++Q D++S L+ + ++ +S L E+ R+
Sbjct: 1216 ITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLN------DSILQATEQRRR 1269
Query: 650 EEVQTLQAELACRQTEVKA--LSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQ 707
E LQ + + K L +++++ + +H S+++ K +Q +++++
Sbjct: 1270 AEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329
Query: 708 VES--------------------GSYDKEVSSMGSRSSSSGSLNARSSAE---DRSPENT 744
+++ +YD+E+ S+ ++ + ++ + + + + +
Sbjct: 1330 LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389
Query: 745 GSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQ 788
G +DN + +++ L E I RL+ + E + +E+ I+Q
Sbjct: 1390 GYRAQIDNLTRENRS-LSEEIKRLKNTLTQTTENLRRVEEDIQQ 1432
Score = 41.2 bits (95), Expect = 0.004
Identities = 73/314 (23%), Positives = 141/314 (44%), Gaps = 40/314 (12%)
Query: 245 KQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEA 304
+QH+N+ + + + I + ++ I D+ K+A+ QL +E ++ + ++ +
Sbjct: 215 EQHINSHRGIHNSIGDYRWQLDK-----IKADLREKSAIYQLEEEYENLLKASFERMDHL 269
Query: 305 RQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLY 364
RQ + + +E + + +E E+ L D + +KNTN ++ R+ QL
Sbjct: 270 RQLQNIIQAT----SREIMWINDCEE--EELLYDWS---DKNTNIAQKQEAFSIRMSQL- 319
Query: 365 ETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKL-TQA 423
E KE +E++KLK++ + V+ A +K++A MD+ + + + T +
Sbjct: 320 EVKE-------KELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHL 372
Query: 424 KEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQ-EKSDQLEMHHAKIK 482
KE A +Q EE +S E A L+ + + K+ +K+ L+ +IK
Sbjct: 373 KENA-----------AYFQFFEEAQSTE--AYLKGLQDSIRKKYPCDKNMPLQHLLEQIK 419
Query: 483 ELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKT 542
ELE + E +++ L K K + + R D S K II R + + V
Sbjct: 420 ELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSN-KPIILRALCDYKQDQKIVHK 478
Query: 543 ADQ--LQEQLQRGK 554
D+ L++ +R K
Sbjct: 479 GDECILKDNNERSK 492
Score = 34.7 bits (78), Expect = 0.41
Identities = 47/220 (21%), Positives = 103/220 (46%), Gaps = 23/220 (10%)
Query: 377 EIDKLKEDIN--SHVIKVKWA-QNKLKAE---MDSHKETKDKLKETTTKLTQAKE-EADQ 429
++DK+K D+ S + +++ +N LKA MD ++ ++ ++ T+ ++ + E ++
Sbjct: 234 QLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEE 293
Query: 430 IRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMH-HAKIKELEDLK 488
+ + D + +E S + ++L V + EL K QE SDQL ++ H ++E
Sbjct: 294 LLYDWSDKNTNIAQKQEAFSIRM-SQLEVKEKELNKLKQE-SDQLVLNQHPASDKIEAYM 351
Query: 489 RTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTA----- 543
T + + + KC+ D L+ ++ E +A ++ L D ++
Sbjct: 352 DTLQTQWSWILQI---TKCI-DVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDK 407
Query: 544 ----DQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIE 579
L EQ++ ++E E + E + +L+N +K ++
Sbjct: 408 NMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQ 447
Score = 31.2 bits (69), Expect = 4.5
Identities = 59/354 (16%), Positives = 138/354 (38%), Gaps = 70/354 (19%)
Query: 416 TTTKLTQAKEEADQIRKNCQDM-----IKTYQESEE------IKSNELDAKLRVTKGELE 464
TTT++T CQD+ I+T +E+++ ++ ++ ++ +G +
Sbjct: 636 TTTEITH--------HGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMT 687
Query: 465 KQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKE 524
+ +DQ HH +K ++EL++++ + + E
Sbjct: 688 LKNLPLADQGSSHHITVK------------INELKSVQNDSQAIA--------------E 721
Query: 525 IINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKR 584
++N+ K + N K LQ ++ Q++EN+ + + + ++ ++ +
Sbjct: 722 VLNQLKDMLANFRGSEKYC-YLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQT 780
Query: 585 ESELLLFTERLTSKNAQLQSESNSLQSQFDKVS---CSESQLQSQCEQMKQTNINLESRL 641
E L ++ RLT E ++ DKV C ++++ K +++ L
Sbjct: 781 EDMLKVYEARLT--------EEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832
Query: 642 LKEEELRKEEVQTL---QAELACRQTEVKALSTQVEELKDEL----------VTQRRKHA 688
K +++ + Q +L +V L+ + + + ++ + Q R +
Sbjct: 833 QKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYR 892
Query: 689 SSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPE 742
+ + K L A+R+ D +ES + + M + + S D+S E
Sbjct: 893 DNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEE 946
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 114 bits (286), Expect = 3e-25
Identities = 182/890 (20%), Positives = 354/890 (39%), Gaps = 165/890 (18%)
Query: 33 NESSKLENESKLLSLNTDKTLCQPN---EHNNRIEAQEN---YIPDHGGGEDSCAKTDTG 86
+E+ + E E K++SL +K Q E +N +A+E I + E + +
Sbjct: 866 SEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNER 925
Query: 87 SENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCT 146
E+ E++ + K + +E ++ + + + L + A E +
Sbjct: 926 LEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 985
Query: 147 KKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKY--LQ 204
+ I+K+ + + L+E + L AE N + K A V E+ V D L+
Sbjct: 986 DEIIAKL---TKEKKALQEAHQQALDDLQAEEDKVNTLTK---AKVKLEQQVDDLEGSLE 1039
Query: 205 QEHIIK--------KLIKENKKHQELFVDICSEKDNLREELKK----------RTETEK- 245
QE ++ KL + K QE +D+ ++K L E LKK R E E+
Sbjct: 1040 QEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQA 1099
Query: 246 ---QHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCE 302
Q +K+L++RIEEL +E++A R TA+ V++L ++++ +E+ +++ E
Sbjct: 1100 LGSQLQKKLKELQARIEELEEELEAER--------TARAKVEKLRSDLSRELEEISERLE 1151
Query: 303 EA----------RQEKEAMVMKYVRGEKESL--------------------------DLR 326
EA +++EA K R +E+ +L+
Sbjct: 1152 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1211
Query: 327 KEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQL----------------------- 363
+ K+ LEK+ + EL+ T+ ++Q+ + K L ++
Sbjct: 1212 RVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVN 1271
Query: 364 --------YETKEGETTRLIREIDKL--------------KEDINSHVIKVKWAQNKLKA 401
+T+ GE +R + E + L ED+ + + A+N L
Sbjct: 1272 DLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAH 1331
Query: 402 EMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKG 461
+ S + D L+E + T+AK E ++ + ++ E + + +L K
Sbjct: 1332 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK 1391
Query: 462 ELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSK 521
+L +++QE + +E +AK LE K R ++E+
Sbjct: 1392 KLAQRLQEAEEAVEAVNAKCSSLEKTKH------------------------RLQNEIED 1427
Query: 522 YKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGS 581
+ R A L K + D++ L KQ+ E + E+ES L ++
Sbjct: 1428 LMVDVERSNAAAAALDKKQRNFDKI---LAEWKQKYEESQSELESSQKEARSLSTELFKL 1484
Query: 582 RKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRL 641
+ E L E +N LQ E + L Q + +L+ +Q++ + L+S L
Sbjct: 1485 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSAL 1544
Query: 642 LK-EEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQ 700
+ E L EE + L+A+L Q + + + ++ E +E+ +R H + L L
Sbjct: 1545 EEAEASLEHEEGKILRAQLEFNQIKAE-IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA 1603
Query: 701 ARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAM 760
R + E+ K++ + S R +AE + + S+ D Q+D A+
Sbjct: 1604 ETRSRN--EALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV 1661
Query: 761 -----LIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYIL 805
L E I ++ R+N ++ + ++ +VE+ + K+ + ++
Sbjct: 1662 RANDDLKENIAIVE----RRNNLLQAELEELRAVVEQTERSRKLAEQELI 1707
Score = 105 bits (263), Expect = 1e-22
Identities = 129/572 (22%), Positives = 237/572 (41%), Gaps = 88/572 (15%)
Query: 202 YLQQEHIIKKLIKENKKHQELFVDICSEK----DNLREELKKRTETEKQHMNTIKQLESR 257
Y QQ +K+ ++E K + D LRE+ ++ TE + + + + S
Sbjct: 1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1367
Query: 258 IEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEK-------EA 310
+ + + + Q + AK + Q +E + +E N KC + K E
Sbjct: 1368 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 1427
Query: 311 MVMKYVRGEKESLDLRKEKETLEK-------KLRDANKELEKNTNKIKQLSQEKGRLHQL 363
+++ R + L K++ +K K ++ ELE + + + LS E +L
Sbjct: 1428 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1487
Query: 364 YETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQA 423
YE RE L+E+I+ L ++ S +T +L++ +L
Sbjct: 1488 YEESLEHLETFKRENKNLQEEISD-----------LTEQLGSSGKTIHELEKVRKQLEAE 1536
Query: 424 KEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKE 483
K E + + + E EE K + K E+E+++ EK +++E
Sbjct: 1537 KMELQSALEEAEASL----EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLR 1592
Query: 484 LEDLKRTFKEGMDELRT--LRTKVKCLEDERLRTEDELSKYKEII---NRQKAEIQNLL- 537
+ D +T + R LR K K +E + E +LS + +Q +Q+LL
Sbjct: 1593 VVDSLQTSLDAETRSRNEALRVKKK-MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1651
Query: 538 -------DKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRK-RESELL 589
D V+ D L+E + ++ L+ E+E L +++ + E SRK E EL+
Sbjct: 1652 DTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVV----EQTERSRKLAEQELI 1707
Query: 590 LFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLK------ 643
+ER+ L S++ SL +Q K+ SQLQ++ E+ Q N E + K
Sbjct: 1708 ETSERV----QLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAA 1763
Query: 644 --EEELRKEE-------------VQTL-----------QAELACRQTEVKALSTQVEELK 677
EEL+KE+ QT+ Q L + +++ L +V EL+
Sbjct: 1764 MMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELE 1823
Query: 678 DELVTQRRKHASSIKDLTKQLQQARRKLDQVE 709
+EL +++++A S+K + K ++ + Q E
Sbjct: 1824 NELEAEQKRNAESVKGMRKSERRIKELTYQTE 1855
Score = 92.4 bits (228), Expect = 2e-18
Identities = 144/633 (22%), Positives = 281/633 (44%), Gaps = 101/633 (15%)
Query: 312 VMKYVRGEKESLDLRKE----KETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETK 367
++K EKE +++E KE LEK KELE+ K+ L QEK L + +
Sbjct: 839 LLKSAEREKEMASMKEEFTRLKEALEKS-EARRKELEE---KMVSLLQEKNDLQLQVQAE 894
Query: 368 EGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLK-ETTTKLTQAKEE 426
+ D+L ++ KVK EM+ E ++++ E T K + ++E
Sbjct: 895 QDNLADAEERCDQLIKNKIQLEAKVK--------EMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 427 ADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELED 486
+++++ D+ T + E+ K T+ +++ +E + E+ KE +
Sbjct: 947 CSELKRDIDDLELTLAKVEKEK--------HATENKVKNLTEEMAGLDEIIAKLTKEKKA 998
Query: 487 LKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQL 546
L+ ++ +D+L+ KV L +++ E ++ + + ++K ++
Sbjct: 999 LQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEK--------------KV 1044
Query: 547 QEQLQRGKQEIE-NLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNA---QL 602
+ L+R K+++E +LK ES+ L ND Q+ E +K++ EL R+ + A QL
Sbjct: 1045 RMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQL 1104
Query: 603 QSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEE---VQTLQAEL 659
Q + LQ++ +++ ++ ++++ +L SR L+E R EE ++Q E+
Sbjct: 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDL-SRELEEISERLEEAGGATSVQIEM 1163
Query: 660 -ACRQTEVKALSTQVEE--LKDELVTQ--RRKHASSIKDLTKQ---LQQARRKLDQVESG 711
R+ E + + +EE L+ E R+KHA S+ +L +Q LQ+ ++KL++ +S
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223
Query: 712 ---SYDKEVSSMGSRSSSSGSLNA------------RSSAED--RSPENTGSSVAV---- 750
D S+M + +L RS AE+ RS + S A
Sbjct: 1224 FKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTE 1283
Query: 751 --DNFPQVD-KAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSY---- 803
+ Q+D K LI ++ R + + ++ +ED +QL EE++ K + +
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQ------LEDLKRQLEEEVKAKNALAHALQSAR 1337
Query: 804 ----ILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAV 859
+LRE+ + ++ +V LS+ +A T + D E E +KL
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRV-LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1396
Query: 860 LEDTLLKNITLKENLQTLGTEIERLIKHQHELE 892
L++ +E ++ + + L K +H L+
Sbjct: 1397 LQEA-------EEAVEAVNAKCSSLEKTKHRLQ 1422
Score = 88.6 bits (218), Expect = 2e-17
Identities = 122/575 (21%), Positives = 250/575 (43%), Gaps = 66/575 (11%)
Query: 144 DCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEK-----CV 198
+ KK +++ +E+ +E + ++ S E +HR+ N + E +V E+
Sbjct: 1388 EAKKKLAQRLQE---AEEAVEAVNAKCSSLEKTKHRLQNEI---EDLMVDVERSNAAAAA 1441
Query: 199 QDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLRE------ELKKRTETEKQHMNTIK 252
DK +Q + K L + +K++E ++ S + R +LK E +H+ T K
Sbjct: 1442 LDK--KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1499
Query: 253 QLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMV 312
+ ++E E+ +QL + T + ++++ K++ + EEA E
Sbjct: 1500 RENKNLQE---EISDLTEQLGSSGKTI-HELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555
Query: 313 MKYVRGEKESLDLRKEKETLEKKLRDANKELEK-NTNKIKQLSQEKGRLHQLYETKEGET 371
K +R + L+ + K +E+KL + ++E+E+ N ++ + L + +
Sbjct: 1556 GKILRAQ---LEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS----LQTSLDAETRSR 1608
Query: 372 TRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSH-KETKDKLKETTTKLTQAKEEADQI 430
+R K++ D+N I++ A N++ AE K + LK+T +L A D +
Sbjct: 1609 NEALRVKKKMEGDLNEMEIQLSHA-NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDL 1667
Query: 431 RKNCQDMIKTYQESEEIKSNELDAKLRVTKGE---LEKQMQEKSDQLEMHHAKIK----- 482
++N +++ + + EL A + T+ E+++ E S+++++ H++
Sbjct: 1668 KENIA-IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQ 1726
Query: 483 ------ELEDLKRTFKEGMDELRTLRTKVK------CLEDERLRTEDELSKYKEIINRQK 530
+L L+ +E + E R K K + E L+ E + S + E + +
Sbjct: 1727 KKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM 1786
Query: 531 AE-IQNLLDKVKTADQL-----QEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKR 584
+ I++L ++ A+Q+ ++QLQ+ + + L+ E+E+ + K + S +R
Sbjct: 1787 EQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERR 1846
Query: 585 ESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKE 644
EL TE +LQ + LQ KV + Q + E +Q N NL +
Sbjct: 1847 IKELTYQTEEDRKNLLRLQDLVDKLQL---KVKAYKRQAE---EAEEQANTNLSKFRKVQ 1900
Query: 645 EELRKEEVQTLQAELACRQTEVKALSTQVEELKDE 679
EL + E + AE + K+ + L +E
Sbjct: 1901 HELDEAEERADIAESQVNKLRAKSRDIGTKGLNEE 1935
Score = 63.9 bits (154), Expect = 6e-10
Identities = 97/572 (16%), Positives = 250/572 (43%), Gaps = 40/572 (6%)
Query: 16 VGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGG 75
+ +T EL+E L + E E + ++N + + +H + E E+ + D
Sbjct: 1380 IQRTEELEEAKKKLAQRLQ----EAEEAVEAVNAKCSSLEKTKHRLQNEI-EDLMVDVER 1434
Query: 76 GEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVEL--RSSTFPESANE 133
+ A D N ++I + + S+ ++++ + EL + + ES
Sbjct: 1435 SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1494
Query: 134 -KTYSESPYD-----TDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKG 187
+T+ + +D T++ S K++ E + +++E+E + + A +
Sbjct: 1495 LETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE 1554
Query: 188 EHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQH 247
E ++ + ++ ++ E I +KL +++++ ++ + D+L+ L T + +
Sbjct: 1555 EGKILRAQ--LEFNQIKAE-IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEA 1611
Query: 248 MNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQE 307
+ K++E + E+ ++ + +++ A+ ++Q L K+ +++ A + ++ ++
Sbjct: 1612 LRVKKKMEGDLNEMEIQLSHA-NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKEN 1670
Query: 308 KEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETK 367
+ + + E +LR E E+ + A +EL + + +++ L + L +
Sbjct: 1671 IAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM 1730
Query: 368 EGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEA 427
+ + ++L E+++ ++ + K K A + K+ +D T+ L + K+
Sbjct: 1731 DADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD----TSAHLERMKKNM 1786
Query: 428 DQIRKNCQDMIKTYQESEEI-------KSNELDAKLRVTKGELEKQMQEKSDQ---LEMH 477
+Q K+ Q + E+E+I + +L+A++R + ELE + + ++ +
Sbjct: 1787 EQTIKDLQHRL---DEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKS 1843
Query: 478 HAKIKEL----EDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEI 533
+IKEL E+ ++ D + L+ KVK + + E++ + + + E+
Sbjct: 1844 ERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL 1903
Query: 534 QNLLDKVKTADQLQEQLQRGKQEI--ENLKEE 563
++ A+ +L+ ++I + L EE
Sbjct: 1904 DEAEERADIAESQVNKLRAKSRDIGTKGLNEE 1935
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 114 bits (286), Expect = 3e-25
Identities = 152/705 (21%), Positives = 317/705 (44%), Gaps = 126/705 (17%)
Query: 150 ISKIKSVSASEDLLEEIESELLSTEFAEH---RVPNGMNKGEHALVLFEKCVQD--KYLQ 204
+ KI++ S ++ E+E+ + E AE RV + E E+ + + L+
Sbjct: 1184 LQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLE 1243
Query: 205 QEHIIKKLIKENKKHQELFV-DICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNK 263
+ ++ ++++ K ++L + D+ +K+ L EEL+++ + E++ + IKQ+E +
Sbjct: 1244 ENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDL----- 1298
Query: 264 EVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQE----KEAMVMKYVRGE 319
A + Q+ + + K Q++ E +++ + C E +A + V G
Sbjct: 1299 ---AFQKQVAEKQLKEK---QKIELEARRKITEIQYTCRENALPVCPITQATSCRAVTGL 1352
Query: 320 KESLDLRKEKETLEK--KLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIRE 377
++ D +K +E ++ +L AN++ E++ +++L+ E L QL +T E RL++
Sbjct: 1353 QQEHDKQKAEELKQQVDELTAANRKAEQD---MRELTYELNAL-QLEKTSSEEKARLLK- 1407
Query: 378 IDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKD---KLKETTTKLTQAKEEADQIRKNC 434
DKL E N+ + K +AE ++ ++ +L +TT K +A +EA ++K
Sbjct: 1408 -DKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKK-- 1464
Query: 435 QDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKI-KELEDLKRTFKE 493
+ + YQ E ++E KG+L++++ D++ HA K ++ L
Sbjct: 1465 --IKRNYQLELESLNHE--------KGKLQREV----DRITRAHAVAEKNIQHLNSQIHS 1510
Query: 494 GMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRG 553
DE R ++ + + L+ + E S +++++ KAE +N DK++ +L E+L++
Sbjct: 1511 FRDEKELERLQICQRKSDHLKEQFEKS-HEQLLQNIKAEKEN-NDKIQ---RLNEELEKS 1565
Query: 554 KQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLL------------------FTERL 595
+ E LK++VE L N+ + ++ + ++L F ++L
Sbjct: 1566 NECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQL 1625
Query: 596 TSKNAQLQSESNSLQSQFDKVSCSE----------SQLQSQCEQM---------KQTNIN 636
S N L ++ + Q K+ C E S+ + +C+Q + N+N
Sbjct: 1626 RSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLN 1685
Query: 637 LESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTK 696
E KEE+ R E+ LQ Q +V+ L+ ++++++DEL +K + +
Sbjct: 1686 AELNASKEEKRRGEQKVQLQ------QAQVQELNNRLKKVQDEL---------HLKTIEE 1730
Query: 697 QLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQV 756
Q+ + L Q ESG + + + + EN S + +D
Sbjct: 1731 QMTHRKMVLFQEESGKFKQSAEEFRKKME-------KLMESKVITENDISGIRLD----- 1778
Query: 757 DKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQ 801
V LQ+ ++R E + E +IK+L ++++ + +Q
Sbjct: 1779 --------FVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQ 1815
Score = 76.6 bits (187), Expect = 9e-14
Identities = 137/741 (18%), Positives = 303/741 (40%), Gaps = 107/741 (14%)
Query: 233 LREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQ 292
L EE KR + +H +L + KA+ + ++ + +L + +A+
Sbjct: 1102 LEEEEIKRCKETSEH--------GAYSDLLQRQKAT----VLENSKLTGKISELERMVAE 1149
Query: 293 RMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQ 352
+Q ++ EE + +EA + + ++ D+ +K E + + +ELE + +
Sbjct: 1150 LKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEA 1209
Query: 353 LSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAE---MDSHKET 409
+E R+ QL E + + + + + + + ++ LK + ++ ++
Sbjct: 1210 AERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQ 1269
Query: 410 KDKLKETTTKLTQAKEEADQIRKNCQ-DMIKTYQESE----EIKSNELDAKLRVTKGELE 464
K+KL E + +EE ++ K + D+ Q +E E + EL+A+ ++T E++
Sbjct: 1270 KNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKIT--EIQ 1327
Query: 465 KQMQEKS---------------DQLEMHHAKIK------ELEDLKRTFKEGMDELRTLRT 503
+E + L+ H K K ++++L ++ ++R L
Sbjct: 1328 YTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTY 1387
Query: 504 KVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQ-----------LQEQLQR 552
++ L+ E+ +E++ K+ ++ ++ L +++ DQ L QL +
Sbjct: 1388 ELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQ 1447
Query: 553 GKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQ 612
+ E +E L + + Q ++E + +L +R+T +A + L SQ
Sbjct: 1448 TTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQ 1507
Query: 613 F----DKVSCSESQL-QSQCEQMKQTNINLESRLL---KEEELRKEEVQTLQAELACRQT 664
D+ Q+ Q + + +K+ +LL K E+ +++Q L EL
Sbjct: 1508 IHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNE 1567
Query: 665 EVKALSTQVEEL-----KDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSS 719
+ L +VEEL + +L+ QR + S L KQ Q R + ++++ + ++ S
Sbjct: 1568 CAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627
Query: 720 MGS--RSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQ-VDKAMLI-------------- 762
+ + + + + S V F Q D+ +I
Sbjct: 1628 TNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAE 1687
Query: 763 -----------ERIVRLQKAHARK-NEKIEFMED--HIKQLVEEIRKKTKIIQSYILREE 808
E+ V+LQ+A ++ N +++ ++D H+K + E++ + + + +EE
Sbjct: 1688 LNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV----LFQEE 1743
Query: 809 SGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNI 868
SG A +F K + +M S + +G+ L+ + + ++ E+ L
Sbjct: 1744 SGKFKQSAEEFRK----KMEKLMESKVITENDISGIRLDF-VSLQQENSRAQENAKLCET 1798
Query: 869 TLKENLQTLGTEIERLIKHQH 889
+KE + L E++ + QH
Sbjct: 1799 NIKELERQLQQYREQMQQGQH 1819
Score = 70.1 bits (170), Expect = 9e-12
Identities = 162/798 (20%), Positives = 331/798 (41%), Gaps = 94/798 (11%)
Query: 153 IKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVL------FEKCVQDKYLQQE 206
+KSV + L+ EI+ + ++ A + M GEH VL FE ++D Q
Sbjct: 647 MKSVVSWHYLINEID-RIRASNVASIKT---MLPGEHQQVLSNLQSRFEDFLEDSQESQV 702
Query: 207 HIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVK 266
+ + K+ V++C + +EL K E E+Q + S + + ++
Sbjct: 703 FSGSDITQLEKE-----VNVCKQ---YYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754
Query: 267 ASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVM-----KYVRGEKE 321
D+LI Q T LH+ + + EQ K E R + + + ++
Sbjct: 755 NCEDRLIRQIRTPLER-DDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 813
Query: 322 SLDLRKEKETLEKKLRDANK---------ELEKNTNKIKQLSQEKGRLHQLYETKEGETT 372
S + + L L++ N+ + K N + + +Q L +LYETK E
Sbjct: 814 SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 873
Query: 373 RLIREIDKLKEDIN------SHVIKVKWAQNKLKAEMDSHKETKDKL----KETTTKLTQ 422
+I + + ++ I+ S V + + + L+ E+ K D++ KE
Sbjct: 874 AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 933
Query: 423 AKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIK 482
KE+ADQ+ + Q++ ++D +LR +G + K ++ D I+
Sbjct: 934 HKEKADQLVERWQNV-----------HVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQ 981
Query: 483 ELEDLKRTFKEGMDE-LRTLRTKV---KCLEDE---RLRTEDELSKYKEIINR--QKAEI 533
++E +R +E E +TL T++ K L E + DE KY E + + E+
Sbjct: 982 QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYEL 1041
Query: 534 QNLLDKVKTADQLQEQLQRGK---------QEIENLKEEVESLNSLINDLQKDIEGSRKR 584
Q + + Q + ++R + QE +L+ +L +L+ K S KR
Sbjct: 1042 QTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKR 1101
Query: 585 ESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKE 644
E + + TS++ + S+ LQ Q V S+L + ++++ L+ + +
Sbjct: 1102 LEEEEIKRCKETSEHG---AYSDLLQRQKATV-LENSKLTGKISELERMVAELKKQKSRV 1157
Query: 645 EELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRK 704
EE + + + EL +Q V+ +S Q + E RR+ ++ + ++ + A R+
Sbjct: 1158 EEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRE----LETIVREKEAAERE 1213
Query: 705 LDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAV-DNFPQVDKAM--L 761
L++V + + E + LN R+ E ENT + + D+ + D ++ L
Sbjct: 1214 LERVRQLTIEAEAK---RAAVEENLLNFRNQLE----ENTFTRRTLEDHLKRKDLSLNDL 1266
Query: 762 IERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNK 821
++ +L + RK + E + IKQ+ +++ + ++ + + ++ L +
Sbjct: 1267 EQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEI 1326
Query: 822 VHLSRRGGIMA---SLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLG 878
+ R + + TS A GL E + +L+ +++ N +++++ L
Sbjct: 1327 QYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELT 1386
Query: 879 TEIERLIKHQHELEQRTK 896
E+ L + E++ +
Sbjct: 1387 YELNALQLEKTSSEEKAR 1404
Score = 66.2 bits (160), Expect = 1e-10
Identities = 115/669 (17%), Positives = 262/669 (39%), Gaps = 68/669 (10%)
Query: 103 KHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDL 162
++I E K+ ++ EL S ++ E + TK + +I++ S + L
Sbjct: 1543 QNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVL 1602
Query: 163 LEE---------------IESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEH 207
++ + +L ST H+ K E KC+++ + ++
Sbjct: 1603 EKQTIQQRCEALKIQADGFKDQLRSTNEHLHK----QTKTEQDFQRKIKCLEEDLAKSQN 1658
Query: 208 IIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKA 267
++ + ++ + + + E NL EL E +++ ++ +++++ELN +K
Sbjct: 1659 LVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKK 1718
Query: 268 SRDQLIAQDVTAKNAVQQLHKEMAQRMEQANK---KCEEARQEKEAMVMKYVRGEKESLD 324
+D+L + + Q H++M E++ K EE R++ E ++ V E +
Sbjct: 1719 VQDELHLKTIEE----QMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISG 1774
Query: 325 LRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKED 384
+R + +L+++ A + + IK+L ++ + + + + ++ KL+++
Sbjct: 1775 IRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDE 1834
Query: 385 INSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQES 444
+ + +V+ + K+ ++ H+ L+ K + AK+ + + + +K Q S
Sbjct: 1835 LIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKD--CTFKPDFEMTVKECQHS 1892
Query: 445 EEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTK 504
E+ S + L + QE E ++ E + F+
Sbjct: 1893 GELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQP----------- 1941
Query: 505 VKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEV 564
L E Y E ++ E+Q D+ +L EIE +++
Sbjct: 1942 ----PGAPLEKEKSQQCYSEYFSQTSTELQITFDETNPITRL--------SEIEKIRD-- 1987
Query: 565 ESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQ 624
++LN+ ++ ++L E +K + +E +L+ + + V +E +
Sbjct: 1988 QALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWML 2047
Query: 625 SQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELAC--RQTEVKALSTQVEELKDELVT 682
C + + L+ ++ L E Q + AC R E K + VT
Sbjct: 2048 EGC----RASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLR------HTVT 2097
Query: 683 QRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPE 742
R+ + + D+ + ++Q R L VE K ++ ++++S L S+ E S
Sbjct: 2098 ARQLVEAKLLDM-RTIEQLRLGLKTVE--EVQKTLNKFLTKATSIAGLYLESTKEKISFA 2154
Query: 743 NTGSSVAVD 751
+ + +D
Sbjct: 2155 SAAERIIID 2163
Score = 55.8 bits (133), Expect = 2e-07
Identities = 159/894 (17%), Positives = 351/894 (39%), Gaps = 136/894 (15%)
Query: 98 SGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVS 157
S N +H+ + + T L+ L NEK E YD I++ K
Sbjct: 365 SRNQERHLDTLHNFVSRATNELIWL---------NEKEEEEVAYDWSERNTNIARKKDYH 415
Query: 158 ASEDLLEEI---ESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKY---LQQEHIIKK 211
A +L+ E+ E + S + ++ + + + +Q ++ LQ +++
Sbjct: 416 A--ELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQ 473
Query: 212 LIKENKKHQELFVDICSEKD---NLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
IKEN + E F D D NL++ ++++ ++ ++I +LE ++E +E
Sbjct: 474 HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEE---- 527
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCE-----------EARQ-------EKEA 310
+++L+ T N + + K + Q ++ N C + RQ + E
Sbjct: 528 KEELLQYKSTIANLMGKA-KTIIQ-LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 585
Query: 311 MVMKYVRGEKESLDLRKEKETLEKKL----RDANKELEKNTNKIKQLSQEKGRL-HQLYE 365
++ K + E + + NKE N+I+Q Q L H+ +
Sbjct: 586 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHI 645
Query: 366 TKEGETT--RLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETT------ 417
+ + LI EID+++ N IK + + +D L+++
Sbjct: 646 NMKSVVSWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFS 704
Query: 418 -TKLTQAKEEADQIRKNCQDMIKTYQESEEIKS---------NELDAKLRVTKGELEKQM 467
+ +TQ ++E + ++ Q+++K+ + E+ +S + +L + L +Q+
Sbjct: 705 GSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI 764
Query: 468 QEKSDQLEMHHA--KIKELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTED------EL 519
+ ++ ++H + +I E E LK+ + D+L T+ K + + + EL
Sbjct: 765 RTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 824
Query: 520 SKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENL-------------KEEVES 566
+ + +N+ + +DK+KT + + + Q + ++ K +E+
Sbjct: 825 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 884
Query: 567 LNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQ 626
L S + + +++ R+ L ++ + + ++ FD QL
Sbjct: 885 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--- 941
Query: 627 CEQMKQTNINLESRLLKEEELRK----------------EEVQTLQAELACRQTE-VKAL 669
E+ + ++ +++RL E + K ++V+T Q ++ Q E K L
Sbjct: 942 VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1001
Query: 670 STQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGS 729
+TQ+ Q++ S I+ ++ + ++ +Q + D E+ +M R+
Sbjct: 1002 ATQLN--------QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQ 1053
Query: 730 LNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQL 789
+ S R + + + + F +D +V L + I+F D +K+L
Sbjct: 1054 ---QKSPVKRRRMQSSADLIIQEF--MDLRTRYTALVTLMTQY------IKFAGDSLKRL 1102
Query: 790 VEEIRKKTKIIQSY-----ILREESGTLSSEASDFNKV-HLSRRGGIMASLYTSHPADNG 843
EE K+ K + +L+ + T+ + K+ L R + + +
Sbjct: 1103 EEEEIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELP 1162
Query: 844 LTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
E + RK Q +ED L+ I + + E+E +++ + E+ ++
Sbjct: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELER 1216
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 114 bits (284), Expect = 5e-25
Identities = 144/666 (21%), Positives = 298/666 (44%), Gaps = 91/666 (13%)
Query: 219 HQELFVDICSEK----DNLREELKKRTETEKQHMNTIKQLESRIEELNK-EVKASRDQLI 273
HQ L D+ SE+ D+ EL +R+ ++ + +++L ++ E K EV + R +
Sbjct: 165 HQSLR-DLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERR 223
Query: 274 AQDV-----TAKNAVQQLHKE---MAQRMEQANKKCEEARQEKEAMVMKYVRG-EKESLD 324
Q++ T + V++ + M+ ++++A KK E E E + +R E E
Sbjct: 224 LQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQ 283
Query: 325 LRKEKETLEKKLRDANKELEKNTNKIKQLSQE--------KGRLHQL---------YETK 367
L +E E + L + E +++++L + KG HQ+ Y+ +
Sbjct: 284 LEQELELSRRLLNQSEGSRETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDE 343
Query: 368 EGETTRLIREIDKLKEDINSHV--IKVKWAQNKLKAEMDSHK---ETKDK----LKETTT 418
+GE R R +++ K+D+ + ++V+ + + +E++ K E KDK L
Sbjct: 344 QGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVE 403
Query: 419 KLTQAKEEADQIRKNCQDMIKTYQES-EEIKSNELDAKLRVTKGELEKQMQEKSDQLEMH 477
LT+ E ++ + D +K Q + ++ A L+++ EL + ++ + Q E +
Sbjct: 404 NLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQIS--ELTRHAEDATKQAERY 461
Query: 478 HAKIKELEDLKRTFKEGMDELRT-LRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNL 536
+++++ E LK ++ ++L+ + ++ + + + E L K E ++ + +
Sbjct: 462 LSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQI 521
Query: 537 LDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLT 596
L K D+L+ QL Q+IENL++E LN ++ E +E +L +
Sbjct: 522 L---KEKDELKTQLYAALQQIENLRKE---LNDVLTKRALQEEELHSKEEKL----RDIK 571
Query: 597 SKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEE--ELRKEEVQT 654
S A L+ E +++ D + ES+L+ Q + Q+ + +E L+EE EL+K + Q
Sbjct: 572 SHQADLELE---VKNSLDTIHRLESELKKQSKI--QSQMKVEKAHLEEEIAELKKSQAQD 626
Query: 655 LQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQ------- 707
+A+L Q +K LS +L ++L + R + +KDL+ QA+ + ++
Sbjct: 627 -KAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQ 685
Query: 708 --VESGSYDKEVSSMGSRSSSSGSLNA-------------RSSAEDRSPENTGSSVAVDN 752
+E + +E+ + S S + + +S AE+ S+ N
Sbjct: 686 LKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKN 745
Query: 753 FPQVDKAML------IERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILR 806
++ + L +R+ + +N+K++ +K +EE K I + ++ R
Sbjct: 746 MAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRR 805
Query: 807 EESGTL 812
E L
Sbjct: 806 MEEARL 811
Score = 95.5 bits (236), Expect = 2e-19
Identities = 108/486 (22%), Positives = 233/486 (47%), Gaps = 67/486 (13%)
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
+K+ ++ K + + S+ +NL EL+ + + Q ++ +K++++ + E K +
Sbjct: 384 VKRCMERKDKEK---AHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDTCEAERKHA 440
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKE 328
Q+ A++A +Q + +++ ++Q+ EEA + +E + +K +ES+ K
Sbjct: 441 DLQISELTRHAEDATKQAERYLSE-LQQSEALKEEAEKRREDLKLK----AQESIRQWKL 495
Query: 329 K-ETLEKKLRDANKELEKNTNKIKQLSQEKGRLH-QLYETKEGETTRLIREIDKLKEDIN 386
K + LE+ L ++ +++ T K Q+ +EK L QLY +++I+ L++++N
Sbjct: 496 KHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAA--------LQQIENLRKELN 547
Query: 387 SHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEE 446
+ K + +L ++ ++KL++ + + E KN D I ESE
Sbjct: 548 DVLTKRALQEEELHSK-------EEKLRDIKSHQADLELEV----KNSLDTIHRL-ESEL 595
Query: 447 IKSNELDAKLRVTKGELEK--------QMQEKSDQLEMHHAKIKELEDLK---------- 488
K +++ ++++V K LE+ Q Q+K+ LEM + IK+L ++
Sbjct: 596 KKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQES-IKDLSAIRADLANKLAEE 654
Query: 489 -RTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQ-- 545
R K + +L L + K ++E +L +++ R+ ++ + L VKT +
Sbjct: 655 ERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQN 714
Query: 546 LQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSE 605
+QE ++ K+E + + +L + + + + R + +L +RLT + Q ++E
Sbjct: 715 IQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENE 774
Query: 606 SNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQA--ELACRQ 663
+ L+ K C + QL+ ++ +I++E EE LR+ E LQ +L C +
Sbjct: 775 NKKLKL---KYQCLKDQLEE-----REKHISIE-----EEHLRRMEEARLQLKDQLLCLE 821
Query: 664 TEVKAL 669
TE +++
Sbjct: 822 TEQESI 827
Score = 78.2 bits (191), Expect = 3e-14
Identities = 102/535 (19%), Positives = 231/535 (43%), Gaps = 55/535 (10%)
Query: 209 IKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
I +L E KK ++ + EK +L EE+ + +++ Q + +++ I++L+ ++A
Sbjct: 588 IHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSA-IRAD 646
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLR-- 326
+A++ AK AV K+++ QA + EE + ++ ++E DL
Sbjct: 647 LANKLAEEERAKKAVL---KDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSS 703
Query: 327 ------KEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDK 380
K ++ +++ ++ KE + N I+ L E + + G+ +L + D+
Sbjct: 704 LQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDR 763
Query: 381 LKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKT 440
L E++ + + K + K + D +E + + L + +E Q++ ++T
Sbjct: 764 LTEELTQNENENKKLKLKYQCLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLL-CLET 822
Query: 441 YQESE-EIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELR 499
QES + E+DA + + ++++ S ++H+ + L + K + +EL+
Sbjct: 823 EQESILGVIGKEIDAACKTFSKDSVEKLKVFSSGPDIHYDPHRWLAESKTKLQWLCEELK 882
Query: 500 TLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIEN 559
+ K L + + +L + + +++E+Q L +++ +QL +++ R K+++
Sbjct: 883 ERENREKNLRHQLMLCRQQL---RNLTENKESELQCLFQQIERQEQLLDEIHREKRDL-- 937
Query: 560 LKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCS 619
+E +++++ E+ +R+ + Q + L+S +K+S
Sbjct: 938 ------------------LEETQRKDEEMGSLQDRVIALETSTQVALDHLESVPEKLSLL 979
Query: 620 E--SQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELK 677
E + C ++T + R K +R+ +Q Q + R K T +E
Sbjct: 980 EDFKDFRDSCSSSERT----DGRYSK-YRVRRNSLQHHQDDTKYRTKSFKGDRTFLEGSH 1034
Query: 678 DELVTQRRKHASSIKDLTKQLQQAR-------RKLDQVESGSYDKEVSSMGSRSS 725
T+ H+SS +D ++ L R K + +KE ++M SS
Sbjct: 1035 ----TRGLDHSSSWQDHSRFLSSPRFSYVNSFTKRTVAPDSASNKEDATMNGTSS 1085
Score = 60.5 bits (145), Expect = 7e-09
Identities = 106/496 (21%), Positives = 210/496 (42%), Gaps = 76/496 (15%)
Query: 415 ETTTKLTQAKEEADQIRKNCQDMIKTYQE--SEEIKSNELDAKLRVTKGELEKQMQEKSD 472
+ T +TQ +R + I+ + E + + DA+ + EL +++ E
Sbjct: 153 QETDDMTQLHGFHQSLRDLSSEQIRLGDDFNRELSRRSRSDAETKRALEELTEKLNEAQK 212
Query: 473 QLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLEDE----RLRTEDELSKYKEIINR 528
Q + + L++L+R E+RT R V+ +D+ L+ ++ L K + +
Sbjct: 213 QEVVSDRVERRLQELER-------EMRTERELVERRQDQLGLMSLQLQEALKKQEAKADE 265
Query: 529 QKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESEL 588
+ I+N L + +T E L++E+E L+N EGSR+ L
Sbjct: 266 HEGAIKNKLRQTET-------------EKNQLEQELELSRRLLNQS----EGSRET---L 305
Query: 589 LLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELR 648
L E L ++ + + + LQ Q ++S +S Q + + + R + E
Sbjct: 306 LHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGE--------DWRFRRGVERE 357
Query: 649 KEEVQTLQAELACRQTEVKALSTQVEELKD--ELVTQRRKH-ASSIKDLTKQLQQARRKL 705
K++++ ++L Q A+++++EE+K E + + H AS +++LT++L+ ++
Sbjct: 358 KQDLEKQMSDLRV-QLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQ- 415
Query: 706 DQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERI 765
Q++ KE+ + + R A+ + E T A D Q ++ +
Sbjct: 416 -QLQMLDRLKEIQNHFDTCEAE-----RKHADLQISELTRH--AEDATKQAERYLS---- 463
Query: 766 VRLQKAHARKNEKIEFMEDHIKQLVEEIRK---KTKIIQSYILREESGTLSSEASDFNKV 822
LQ++ A K E + ED + E IR+ K K ++ L ++S T+ N++
Sbjct: 464 -ELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLER-ALEKQSETVDELTGKNNQI 521
Query: 823 HLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIE 882
L + + LY + L+ L+ L D L K +E L + ++
Sbjct: 522 -LKEKDELKTQLYAA------------LQQIENLRKELNDVLTKRALQEEELHSKEEKLR 568
Query: 883 RLIKHQHELEQRTKKT 898
+ HQ +LE K +
Sbjct: 569 DIKSHQADLELEVKNS 584
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 112 bits (281), Expect = 1e-24
Identities = 179/887 (20%), Positives = 382/887 (43%), Gaps = 132/887 (14%)
Query: 3 ETDHIASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQ-PNEHNN 61
+T+ + + SSD + EL +D +L +S LE +S+ LSL T C+ N+
Sbjct: 2012 KTELLQTLSSDVS-----ELLKDKTHLQEKLQS--LEKDSQALSL----TKCELENQIAQ 2060
Query: 62 RIEAQENYIPDHGGGEDSCAKTDTGSENSE---QIANFPSGNFAKHISKTNETEQKVTQI 118
+ +E + + + +++D N + A G FA +S T E ++ +
Sbjct: 2061 LNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRG 2120
Query: 119 LVELRSSTFPESANE----KTYSESPYDTDCTKKFISKI-KSVSASEDLLEEIESELLST 173
+ +LR + + + E + D K + + + + SE+ E + + ++
Sbjct: 2121 IEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENS 2180
Query: 174 EFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNL 233
+ + + + +L +FE + ++E++ K++ ++ + EL + S K L
Sbjct: 2181 KAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLL 2240
Query: 234 REELKKRTETEKQHMNTIKQLESRIEELNKEVKA---SRDQLIAQDVTAKNAVQQLHKEM 290
E+ + + +++ ++ L+++++ELN+ V A ++ + A + + +++ H ++
Sbjct: 2241 EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH-QL 2299
Query: 291 AQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEK-ETLEKKLRDANKELEKNTNK 349
+E+ + E A ++K+ V++ ++ + DL K + E LE++L +
Sbjct: 2300 RNSIEKLRARLE-ADEKKQLCVLQQLKESEHHADLLKGRVENLEREL------------E 2346
Query: 350 IKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKET 409
I + +QE L E +GE L +I+ + + + L+ ++ + +
Sbjct: 2347 IARTNQEHAALEA--ENSKGEVETLKAKIEGMTQSLRG-----------LELDVVTIRSE 2393
Query: 410 KDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQE 469
K+ L K + E + I + ++++ QE E+ K QM+E
Sbjct: 2394 KENLTNELQKEQERISELEIINSSFENIL---QEKEQEKV----------------QMKE 2434
Query: 470 KSDQ-LEMHHAKIKELEDLKRTFKEGMDELRT----LRTKVKCLEDERLRTEDELSKYKE 524
KS +EM ++KEL + + + L ++V+CLE E+ + L + K
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKN 2494
Query: 525 IINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKR 584
++ + L+ +V+ Q +L++ +EI LK +++ L++ L + +EG +
Sbjct: 2495 NYIVLQSSVNGLIQEVEDGKQ---KLEKKDEEISRLKNQIQDQEQLVSKLSQ-VEGEHQL 2550
Query: 585 ESELLLFTERLT-----------SKNAQLQSESNSLQSQF-------------------- 613
E L LT SKNA LQ LQS +
Sbjct: 2551 WKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEK 2610
Query: 614 -DKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQ 672
+K++ E++LQ + +M Q L+ L E+ E+Q L E+ + ++K L+ +
Sbjct: 2611 VNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLE 2670
Query: 673 VEELKDEL-------VTQRRKHASSIKDLTKQLQQARRK-----LD-----QVESGSY-D 714
ELK L V + K I + +L +A +K LD +VE +Y +
Sbjct: 2671 NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE 2730
Query: 715 KEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHAR 774
K S SS ++ S+++ + ++ + + K ++ + +L+K + R
Sbjct: 2731 KLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENER 2790
Query: 775 KNEKIEFMEDHIKQLVEE---IRKKTKIIQSYILREESGTLSSEASD 818
K++ + KQL EE ++K+ +Q+ ++++GT+ D
Sbjct: 2791 AQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVD 2837
Score = 103 bits (258), Expect = 5e-22
Identities = 155/813 (19%), Positives = 344/813 (42%), Gaps = 111/813 (13%)
Query: 160 EDLLEEIE-SELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENK- 217
++LL+ +E SE L+++ H + + ++++L E+ + ++ E
Sbjct: 1854 QELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKAS 1913
Query: 218 -KHQELFVD----------ICSEKDN---------LREELKKRTETEKQ---HMNTIKQL 254
+H+ L+++ +C EKDN L EEL T Q ++T+ +
Sbjct: 1914 IEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKK 1973
Query: 255 ESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRME-----------------QA 297
+ +++L++++K +L + + +Q E+ ++ E
Sbjct: 1974 TTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL 2033
Query: 298 NKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQ-- 355
+K + ++ +A+ + E + L KEKE L K+ L ++ + +S+
Sbjct: 2034 QEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKAL 2093
Query: 356 -----EKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETK 410
EKG + + E +L R I+KL+ I + K KLK + K
Sbjct: 2094 EAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLK 2153
Query: 411 DKLKETTTKLTQAKEEADQIRKNCQ------DMIKTYQE--SEEIKSNELD-AKLRVTKG 461
DK++ +L ++E + + + + + +KT E + +K ELD LR K
Sbjct: 2154 DKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKE 2213
Query: 462 ELEKQMQEKSDQL---------------EMHHAKIKELEDLKRTFKEGMDELRTLRTKVK 506
L KQ+QEK QL E A+I+ E+ K + ++L+ L V
Sbjct: 2214 NLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVA 2273
Query: 507 CL-EDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGK-QEIENLKEEV 564
L D+ + E S I ++ +++N ++K++ + E+ Q Q+++ +
Sbjct: 2274 ALCGDQEIMKATEQSLDPPI--EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA 2331
Query: 565 ESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQ 624
+ L + +L++++E +R + L E + E +L+++ + ++ S L+
Sbjct: 2332 DLLKGRVENLERELEIARTNQEHAALEAENS-------KGEVETLKAKIEGMTQSLRGLE 2384
Query: 625 SQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQR 684
++ NL + L KE+E R E++ + + + ++E + E V +
Sbjct: 2385 LDVVTIRSEKENLTNELQKEQE-RISELEIINS----------SFENILQEKEQEKVQMK 2433
Query: 685 RKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENT 744
K +++++ L QL++ ++ + + D+E ++ SS +++
Sbjct: 2434 EKSSTAMEMLQTQLKELNERVAALHN---DQEACKAKEQNLSS---QVECLELEKAQLLQ 2487
Query: 745 GSSVAVDNFPQVDKAM--LIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQS 802
G A +N+ + ++ LI+ + ++ +K+E+I +++ I+ + + K +++
Sbjct: 2488 GLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGE 2547
Query: 803 YILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLED 862
+ L +E + V L ++ ++ S S TLE+ + L+ LE
Sbjct: 2548 HQLWKEQNLELRNLT----VELEQKIQVLQSKNASLQD----TLEVLQSSYKNLENELEL 2599
Query: 863 TLLKNITLKENLQTLGTEIERLIKHQHELEQRT 895
T + ++ E + + + L + HE+ Q+T
Sbjct: 2600 TKMDKMSFVEKVNKMTAKETELQREMHEMAQKT 2632
Score = 97.4 bits (241), Expect = 5e-20
Identities = 190/990 (19%), Positives = 403/990 (40%), Gaps = 156/990 (15%)
Query: 42 SKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIAN--FPSG 99
S + S +KT + ++ R + ++ + GE + + + ++ AN F
Sbjct: 214 SSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDN 273
Query: 100 NFAKHI-----SKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTK-KFISKI 153
+ + H+ ++ E K+ ++ + L+ + E + K + I K
Sbjct: 274 SSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKE 333
Query: 154 KSVSASEDLL-------EEIESELLSTEFAEHRVPNGMN----KGEHALVLFEKCVQDKY 202
K ++ D L ++ ++ + E ++ ++ E A E+ +++K
Sbjct: 334 KVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEK- 392
Query: 203 LQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRT------ETEKQHMNTIKQ-LE 255
++ ++L ++ + Q L + K L +EL++ + E + ++KQ LE
Sbjct: 393 --EKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLE 450
Query: 256 SRIEELNKEVKASRDQLIAQDVTA---KNAVQQLHKEMAQRMEQANKKCEEA-RQEKEAM 311
+ +EE +++ + A + + +++++ KE + +K E E E
Sbjct: 451 NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELK 510
Query: 312 VMKYVRGEKESL--DLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEG 369
+K + ++ +++ + + E LRD +++ + N L+ EK +L K+
Sbjct: 511 NIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS---LTLEKLKLAVADLEKQR 567
Query: 370 ETTR-LIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEAD 428
+ ++ L+++ + E +N + K + L + ++ K+ ++LKE T + K E +
Sbjct: 568 DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENE 627
Query: 429 QI-------RKNCQDMI---KTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHH 478
++ ++N Q I +T ++++IKS+E + ++R + + E E + +
Sbjct: 628 KLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLD 687
Query: 479 AKIKELEDLKRTFKEGM------DELRTLRTKVKCLEDERLRTEDELSKYK------EII 526
+K E+E K + E D+ + CL+ +L + E ++K EI+
Sbjct: 688 SKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIM 747
Query: 527 NRQK------AEIQNLLDKVKTADQ---LQEQLQRGKQEIENLKEEVESLNSLINDLQKD 577
++ + AE ++L D +K+ D E QR + S ++I +
Sbjct: 748 DKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGE---- 803
Query: 578 IEGSRKRE-SELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNIN 636
+GS E SE L ++ +A LQ+ +SL+ + S LQ QCE++ Q
Sbjct: 804 -QGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGE 862
Query: 637 LESRLLKEEELRK-------EEVQTLQAELACRQTEVKALSTQVEELKDEL--------- 680
+E L+K E++ + + + LQ + + Q V + +E + EL
Sbjct: 863 IEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVET 922
Query: 681 ----VTQRRKHASSIKDLTKQLQ--QARRKLDQVESGSY----DKEVSSMGSRSSSSGSL 730
+ + +K ++D K+LQ L++ E S +E+ + + + +
Sbjct: 923 EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEI 982
Query: 731 NARSSAEDRSPENTGSSVA-------------VDNFPQVDKAMLIER----------IVR 767
NA + E + S A D + Q +K +L++R + +
Sbjct: 983 NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQ-EKLILLQRCEETGNAYEDLSQ 1041
Query: 768 LQKAHARKNEKIEFM-----------EDHIKQLVEEIRKK-----TKII------QSYIL 805
KA KN K+E + ++ ++QL E K+ TK+ Q+ +L
Sbjct: 1042 KYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLML 1101
Query: 806 REES--GTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDT 863
E+ L SE +D S GG+ + T N ++ E+N LQ +
Sbjct: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQN----KMQKEVNDLLQE--NEQ 1155
Query: 864 LLKNITLKENLQTLGTEIERLIKHQHELEQ 893
L+K + K Q L +E R + E E+
Sbjct: 1156 LMKVMKTKHECQNLESEPIRNSVKERESER 1185
Score = 84.7 bits (208), Expect = 3e-16
Identities = 103/477 (21%), Positives = 216/477 (45%), Gaps = 60/477 (12%)
Query: 164 EEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELF 223
+ + S++ E + ++ G+++ ++ ++ + V + E +KL K++++ L
Sbjct: 2469 QNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLK 2528
Query: 224 VDICSEKDNLREELKKRTETEKQHM----------NTIKQLESRIEELNKEVKASRDQLI 273
I ++ + + K ++ E +H N +LE +I+ L + + +D L
Sbjct: 2529 NQIQDQE----QLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLE 2584
Query: 274 AQDVTAKNAVQQLHKEMAQRM---EQANK---KCEEARQEKEAMVMKYVRGEKESLDLRK 327
+ KN +L +M E+ NK K E ++E M K ++E L
Sbjct: 2585 VLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEE---LSG 2641
Query: 328 EKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINS 387
EK L +L+ +E++ + +++K+L+ E L + + + + + K++E+I
Sbjct: 2642 EKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ---VEKEGKVREEIAE 2698
Query: 388 HVIKVKWAQNKLKAEM-DSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEE 446
+ +++ A+ K +A + D++K+ + +++ KLT +KEE +K D++K+ +E
Sbjct: 2699 YQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLT-SKEECLSSQKLEIDLLKSSKE--- 2754
Query: 447 IKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVK 506
EL+ L+ T LE+ + K D L K + LK+ + +++ L K
Sbjct: 2755 ----ELNNSLKATTQILEELKKTKMDNL-------KYVNQLKKENERAQGKMKLLIKSCK 2803
Query: 507 CLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVES 566
LE+E KEI+ ++ +++Q +K KT + ++ EI+ LKE +E
Sbjct: 2804 QLEEE-----------KEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE- 2851
Query: 567 LNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQL 623
+ K+ + + LL+ E+L L+++ L SQ K S L
Sbjct: 2852 ------EKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPL 2902
Score = 83.6 bits (205), Expect = 8e-16
Identities = 178/806 (22%), Positives = 314/806 (38%), Gaps = 166/806 (20%)
Query: 213 IKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESR-IEELN------KEV 265
I+E KK L D E L E L EK+ M++I L R IEEL KE+
Sbjct: 927 IQELKKSNHLLEDSLKELQLLSETLS----LEKKEMSSIISLNKREIEELTQENGTLKEI 982
Query: 266 KASRDQ----LIAQDVTAKNAVQQLHKEMAQRMEQANK-------KCEEARQEKEAMVMK 314
AS +Q LI + + N + + K +++ +Q + +CEE E + K
Sbjct: 983 NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQK 1042
Query: 315 YVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETK----EGE 370
Y ++++ LE L + E N+++QL + + HQ + TK E
Sbjct: 1043 YKAAQEKN-------SKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEER 1095
Query: 371 TTRLIREIDKLKEDINSHVI----KVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEE 426
L+ E++ +++ + S + K LK E+ + KE ++K+++ L Q E+
Sbjct: 1096 NQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQ 1155
Query: 427 ADQIRKN---CQDMIKT-------YQESE------------EIKSNELDA---------- 454
++ K CQ++ +ESE E+K LD+
Sbjct: 1156 LMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEA 1215
Query: 455 -----KLRVTKGELEKQMQ-----------EKSDQLEMHHAKIKELEDLKRTFKE----G 494
+L++ + E EK+ E S+ +M +I L+D + +E G
Sbjct: 1216 MLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISG 1275
Query: 495 MDELRTLRTK---VKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQ 551
EL T + ++C + +EL K EI+ +K E+ L+ ++ + +
Sbjct: 1276 PHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRS--ECITATR 1333
Query: 552 RGKQEIENLKEEVESLNS----LINDLQKDIEGSRKRES--------------------- 586
+ +E+ L EV+ LN L +L +DI G E
Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHL 1393
Query: 587 -----ELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRL 641
E+ + L K LQSE L Q ++S S+LQ+ + +K N+ L + L
Sbjct: 1394 TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNL 1453
Query: 642 LKEEELRKEEVQTLQAELACRQTEVKALSTQVEE-LKDELVTQRRKHASSIKDLTKQLQQ 700
+ Q +L VK + +EE L L + +SS+ L
Sbjct: 1454 -----------RNFQGDL------VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLG----- 1491
Query: 701 ARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVD--- 757
+S Y + G S S A S+ + E SS+ +N + +
Sbjct: 1492 --------DSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPS 1543
Query: 758 -KAMLIERIVRLQKAHARKNEKI-EFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSE 815
A +E + L + + + EK+ E ME +EI++ +++ S R+E L +
Sbjct: 1544 APAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSE--RQELDCLRKQ 1601
Query: 816 ASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEI---NRKLQAV-LEDTLLKNITLK 871
N+ + + + + A+ T +LSLE+ +LQ + L L I +
Sbjct: 1602 YLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGIDTE 1661
Query: 872 ENLQTLGTEIERLIKHQHELEQRTKK 897
+ +Q + +H E +RT K
Sbjct: 1662 DAIQGRNESCDISKEHTSETTERTPK 1687
Score = 68.9 bits (167), Expect = 2e-11
Identities = 129/710 (18%), Positives = 307/710 (43%), Gaps = 122/710 (17%)
Query: 232 NLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMA 291
+L+EE R ET +++LES E + ++ +++ +Q + +Q+L + ++
Sbjct: 1530 SLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLS 1589
Query: 292 QRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIK 351
RQE + + +Y+ E E ++KL E+E
Sbjct: 1590 SE-----------RQELDCLRKQYL----------SENEQWQQKLTSVTLEMES------ 1622
Query: 352 QLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKD 411
+L+ EK + QL + E E RL ++ L D++S + ++ ++ +S +K+
Sbjct: 1623 KLAAEKKQTEQL--SLELEVARL--QLQGL--DLSSRSLLGIDTEDAIQGRNESCDISKE 1676
Query: 412 KLKETTTKLTQA-------KEEADQIRKNCQDMIKT------------------YQESEE 446
ETT + + K+ + + + + +T Y+ E
Sbjct: 1677 HTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGE 1736
Query: 447 IK---SNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRT 503
K S+E ++L + M +Q ++H+ +++ +K T E + L +
Sbjct: 1737 DKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLR----VKETSNENLRLLHVI-- 1790
Query: 504 KVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEE 563
ED + E L++ KE+ ++ + L+ K++ +L++ + K+E +L E+
Sbjct: 1791 -----EDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEK 1845
Query: 564 VESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNA--QLQSESNSLQSQFDKVSCSES 621
+E + +L + +E S S+L + ++ + ++ + ++S + +F V S
Sbjct: 1846 LEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELS 1905
Query: 622 QLQSQCEQMKQTNINLESRL--LKEEEL-RKEEVQTLQAELACRQTEVKALSTQVEELKD 678
+++S+ ++ + LE+ L ++ E+L +++ + Q + C + E+ ++++ +L+
Sbjct: 1906 RIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRG 1965
Query: 679 ELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAED 738
EL T +K +++ L++++++ ++L+ S S L+ AE
Sbjct: 1966 ELDTMSKK-TTALDQLSEKMKEKTQELE-----------------SHQSECLHCIQVAEA 2007
Query: 739 RSPENTGSSVAVDNFPQ---VDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRK 795
E T + + DK L E++ L+K ++ + + ++ + ++ K
Sbjct: 2008 EVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEK----DSQALSLTKCELENQIAQLNK 2063
Query: 796 KTKIIQSYILREESGTLSSEASDFNKVHLSR--------RGGIMASLYTS----HPADNG 843
+ +++ + ES SD+ K+++S+ +G L ++ H G
Sbjct: 2064 EKELL---VKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRG 2120
Query: 844 L-TLELSLEINRKLQAVLEDTL----LKNITLKENLQTLGTEIERLIKHQ 888
+ L + +E + K Q + + L +N +LK+ ++ L E++ ++Q
Sbjct: 2121 IEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQ 2170
Score = 46.6 bits (109), Expect = 1e-04
Identities = 103/563 (18%), Positives = 225/563 (39%), Gaps = 104/563 (18%)
Query: 436 DMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGM 495
D +K ++ + + + L+A L+ K ++E + E ++ + ++ E L++T ++
Sbjct: 28 DKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKIS 87
Query: 496 DELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTAD----------- 544
EL+ ++V E + + ++ K ++ + R K+E++ ++AD
Sbjct: 88 HELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQK 147
Query: 545 ------------------QLQEQLQRGKQEIENLKEEVESL------------------- 567
L+E+ + +E + L+ EV++L
Sbjct: 148 IFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDI 207
Query: 568 -----NSLINDLQKDIEGSR----------KRESELLLFT--ERLTSKNAQLQSESNSLQ 610
+S + Q++ S +R+ F+ + +T + LQ
Sbjct: 208 ARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDAN 267
Query: 611 SQFDKVSCSE---SQLQSQCEQMKQTNINLESRLLKEEELRKEEV---QTLQAELACRQT 664
S F S S QL++Q ++++ LE RL E+ K +V Q LQ +L +
Sbjct: 268 SSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKV 327
Query: 665 EVKALSTQVEELKDELV--TQRRKHASS--------IKDLTKQL-------QQARRKLDQ 707
E+ + + +DELV T + AS+ +K LT+ L + AR L+Q
Sbjct: 328 ELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQ 387
Query: 708 ---VESGSYDKEVS----SMGSRSSSSGSLNARSSAEDRSPENTGS--SVAVDNFPQVDK 758
+ + +E+S S + + AR + E + +N + +D V K
Sbjct: 388 KIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSV-K 446
Query: 759 AMLIERIVRLQKAHARKNEKI---EFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSE 815
L + ++ R + + E+ +++ +EE++K+ +++S+ ++ E
Sbjct: 447 QQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLE 506
Query: 816 ASDFN-KVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKENL 874
A N K L++ + + + + +L +IN++ ++ + L + E
Sbjct: 507 AELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQ 566
Query: 875 QTLGTEIERLIKHQHELEQRTKK 897
+ ++ L K +H +EQ K
Sbjct: 567 RDCSQDL--LKKREHHIEQLNDK 587
Score = 41.2 bits (95), Expect = 0.004
Identities = 53/205 (25%), Positives = 89/205 (43%), Gaps = 42/205 (20%)
Query: 532 EIQNLLDKVKTA--------DQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRK 583
E++ LDK+K D L+ LQ+ KQ++EN K E +L K
Sbjct: 22 ELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNL---------------K 66
Query: 584 RESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLK 643
RE++ L+ E S Q S+ LQ + +V+ E QL S +Q+++ L+ R
Sbjct: 67 RENQRLM--EICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK-RCKS 123
Query: 644 EEELRKEEVQTLQAELACRQTEVKALST-----------QVEELKDEL---VTQRRKHAS 689
E E ++ Q+ L T K +T + E+LK++ V +R++ +
Sbjct: 124 ELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
Query: 690 SIKDLTKQLQQARRKLDQVESGSYD 714
+K L Q ++A + L Q D
Sbjct: 184 EVKAL--QAKKASQTLPQATMNHRD 206
Score = 32.3 bits (72), Expect = 2.0
Identities = 77/412 (18%), Positives = 168/412 (40%), Gaps = 37/412 (8%)
Query: 491 FKEGM-----DELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQ-------NLLD 538
+KEG+ +++ L ++ L+ E+ + + +L + + +QK +++ NL
Sbjct: 8 WKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKR 67
Query: 539 KVKTADQLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSK 598
+ + ++ E L++ KQ+I + E++ S +N + + +K+ +L +R S+
Sbjct: 68 ENQRLMEICESLEKTKQKISH---ELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 599 NAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAE 658
+ Q + S + + + + + + + L ++ EE + L+AE
Sbjct: 125 LERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAE 184
Query: 659 LACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVS 718
+ Q + KA T + + R + +SS+ Q + + S S +
Sbjct: 185 VKALQAK-KASQTLPQATMNHRDIARHQASSSVFS-----WQQEKTPSHLSSNSQRTPIR 238
Query: 719 SMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEK 778
S S SG S RS G A +F D + + +L+ + K
Sbjct: 239 RDFSASYFSGEQEVTPS---RSTLQIGKRDANSSF--FDNSSSPHLLDQLKAQNQELRNK 293
Query: 779 IEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSH 838
I +E ++ +E++ + Q L+ E + E + KV R ++ T+
Sbjct: 294 INELELRLQGHEKEMKGQVNKFQELQLQLEKAKV--ELIEKEKVLNKCRDELVR---TTA 348
Query: 839 PADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHE 890
D T +LE +KL+ + ED + ++N ++ +E+ IK + +
Sbjct: 349 QYDQASTKYTALE--QKLKKLTEDLSCQ----RQNAESARCSLEQKIKEKEK 394
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 112 bits (280), Expect = 2e-24
Identities = 153/739 (20%), Positives = 322/739 (43%), Gaps = 89/739 (12%)
Query: 22 LKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCA 81
L+ D + + NE ++LEN++ L+ + C +E +N E ++ +I +H +
Sbjct: 857 LQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHN--EKEKCFIKEHENLKPLLE 914
Query: 82 KTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPY 141
+ + +E I + AK S N+ V ++ E + + EK
Sbjct: 915 QKELRDRRAELI--LLKDSLAKSPSVKNDPLSSVKEL--EEKIENLEKECKEK------- 963
Query: 142 DTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDK 201
++ I+KIK V+ +E++S T+ + + + ++ +
Sbjct: 964 -----EEKINKIKLVAVKAK--KELDSSRKETQTVKEELESLRSEKD------------- 1003
Query: 202 YLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEEL 261
Q ++ LI+ + ++ L ++ E+ ++ + EK+ N E RIE+L
Sbjct: 1004 --QLSASMRDLIQGAESYKNLLLEY--------EKQSEQLDVEKERANNF---EHRIEDL 1050
Query: 262 NKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRME--QANKKCEEAR----QEKEAMVMKY 315
++++ S Q + ++++ R+E Q+N K E + Q +AMV K
Sbjct: 1051 TRQLRNSTLQC--------ETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKE 1102
Query: 316 VRGEKESLDLR-KEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRL 374
+ EK + + KE T +L + +L+K ++++ QE +L + +TT +
Sbjct: 1103 LEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQEL----ELVKKDAQQTTLM 1158
Query: 375 IREI---DKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIR 431
EI ++L +++N + L+ E+ K+ ++ L+E T L + ++ ++
Sbjct: 1159 NMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKN 1218
Query: 432 -KNCQDMIKTYQESEEIKSNELDAKLRVT--KGELEKQMQE----KSDQLEMHHAKIKEL 484
K Q ++KT +E + K E D + KGELE Q+ K E+ K K
Sbjct: 1219 TKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIH 1278
Query: 485 EDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTAD 544
E LK + ++ L + +V L++E + E + K + N+L + K
Sbjct: 1279 EHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKS 1338
Query: 545 QLQEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQS 604
Q + + KQE E+L+ ++ L + D Q +++ + L + L ++ ++
Sbjct: 1339 MSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQ 1398
Query: 605 ESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELR----KEEVQTLQAE-- 658
E+ S +++ + CS +QS+ MK + S+L + E+ +++V+ LQ E
Sbjct: 1399 ETVSKEAELREKLCS---IQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHR 1455
Query: 659 --LACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKE 716
+ Q ++ + Q+ +LK+E T R SS + L ++ L ++ + +E
Sbjct: 1456 KTVETLQQQLSKMEAQLFQLKNEPTT--RSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE 1513
Query: 717 VSSMGSRSSSSGSLNARSS 735
G ++ + S+++ S+
Sbjct: 1514 -EGEGMETTDTESVSSAST 1531
Score = 104 bits (260), Expect = 3e-22
Identities = 157/744 (21%), Positives = 333/744 (44%), Gaps = 104/744 (13%)
Query: 200 DKYLQQEHIIKKLIKENKKHQE---LFVDICSEKDNLREELKKR----TETEKQHMNTIK 252
+K L Q+ ++ +L K QE +++ S++D + +EL+ + TE + +N +K
Sbjct: 545 EKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLK 604
Query: 253 QLESRIEELNKEVKASRDQLIAQDVTAK-NAVQQLHKEMAQRMEQANKKCEEARQEKEAM 311
++ +K K R++ + ++ K Q + E+ Q++ + EE +EK+
Sbjct: 605 NSHEEMDNFHK--KCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQN 662
Query: 312 VMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEG-- 369
K + + L ++KE L +++ +E K +++ KQLS++ L KE
Sbjct: 663 DQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRD---LEVFLSQKEDVI 719
Query: 370 ---ETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEE 426
T+L +++ + E+ ++ K +N+ ++ + LKE +++++ EE
Sbjct: 720 LKEHITQLEKKLQLMVEEQDN---LNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEE 776
Query: 427 ADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLE-----MHHAKI 481
D + ++++ ES AK+ K L Q EK +LE + +
Sbjct: 777 KDVV-----NVLQAVGESL--------AKINEEKCNLAFQRDEKVLELEKEIKCLQEESV 823
Query: 482 KELEDLKRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVK 541
+ E+LK ++ E LR +++ ++ E+ + +L + K + + E QNLL +V+
Sbjct: 824 VQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVE 883
Query: 542 TADQLQEQLQRGKQEIENLKE-----EVESLNSLINDLQKDIEGSRKRESELLLFTERLT 596
Q K EI N KE E E+L L+ QK++ R R +EL+L + L
Sbjct: 884 EVSQ-----TCSKSEIHNEKEKCFIKEHENLKPLLE--QKEL---RDRRAELILLKDSLA 933
Query: 597 SKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQ 656
+ +S++ +K+ E + + + E++ + + + + KE + ++E QT++
Sbjct: 934 KSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL-VAVKAKKELDSSRKETQTVK 992
Query: 657 AELACRQTEVKALSTQVEEL----------------KDELVTQRRKHASS----IKDLTK 696
EL ++E LS + +L + E + ++ A++ I+DLT+
Sbjct: 993 EELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTR 1052
Query: 697 QLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQV 756
QL+ + + + + S + D ++ + + S++ L + R+ V
Sbjct: 1053 QLRNSTLQCETINSDNEDL-LARIETLQSNAKLLEVQILEVQRAK------------AMV 1099
Query: 757 DKAMLIERIVRLQ--KAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYILREESGTL-S 813
DK + E++ + Q K HA ++E ++ +++ ++++K + ++ + TL +
Sbjct: 1100 DKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMN 1159
Query: 814 SEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQAVLEDTLLKNITLKEN 873
E +D+ + +M L N +L EI K+Q ++TL + IT +
Sbjct: 1160 MEIADYER--------LMKELNQKLTNKNNKIEDLEQEI--KIQKQKQETLQEEIT---S 1206
Query: 874 LQTLGTEIERLIKHQHELEQRTKK 897
LQ+ + E +L +TKK
Sbjct: 1207 LQSSVQQYEEKNTKIKQLLVKTKK 1230
Score = 90.5 bits (223), Expect = 6e-18
Identities = 161/718 (22%), Positives = 308/718 (42%), Gaps = 111/718 (15%)
Query: 212 LIKENKKHQELFVDI---CSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKAS 268
LIK KK L C+E + EEL+ + TE + IK L R++ L E +
Sbjct: 30 LIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTG-DIIKALTERLDALLLEKAET 88
Query: 269 RDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKE 328
Q ++ +++ + +M Q +E + K +A +E E + YV KE +L+ E
Sbjct: 89 EQQCLS--------LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYV---KEIENLKNE 137
Query: 329 KETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSH 388
+ K + L+K + E + E +L EI+K++
Sbjct: 138 LMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQ 197
Query: 389 VIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIK 448
++ + Q +L A T D+ KET T+L Q++I+ + +
Sbjct: 198 IL---YLQKQLDA-------TTDEKKETVTQL--------------QNIIEANSQHYQKN 233
Query: 449 SNELDAKLRVTKGELEKQMQEKSDQLEM----HHAKIKELEDLKRTF-KEGMDELRTLRT 503
N L +L K +++++E Q+E H A+I +L +LK K+ + ++
Sbjct: 234 INSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQK 293
Query: 504 KVKC-LEDERLRTE--DELSKYKEIINRQKAEIQNLL-DKVKTADQLQEQLQRGKQEIEN 559
K +C LE+ R T ++ ++ I+ ++ ++ ++ +KVK L++ L+ + +
Sbjct: 294 KYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVK---HLEDTLKELESQHSI 350
Query: 560 LKEEVESLNSLINDLQKDI-----EGSRKRE------SELLLFTERLTSKNAQLQSESNS 608
LK+EV +N+L L+ D E +RE +ELLL E +L+SE
Sbjct: 351 LKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAG 410
Query: 609 LQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKA 668
L QF C ++Q N ++S LKE+ +KE + + L+ + E
Sbjct: 411 LNKQF-------------CYTVEQHNREVQS--LKEQH-QKEISELNETFLSDSEKEKLT 454
Query: 669 LSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSG 728
L +++ LK++ +++ +I L + + ++ Q E G S G S
Sbjct: 455 LMFEIQGLKEQCENLQQEKQEAI--LNYESLREIMEILQTELG------ESAGKISQEFE 506
Query: 729 SLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHAR---KNEKIEFMEDH 785
S+ + +++ + + +K L+E + RLQ + + + E + +E+
Sbjct: 507 SMKQQQASDVHELQQKLRTAF------TEKDALLETVNRLQGENEKLLSQQELVPELENT 560
Query: 786 IKQLVEE--IRKKTKIIQSYILREESG---TLSSEASDF-NKVHLSRRGGIMASLYTSHP 839
IK L E+ + + + +L+E G +L+ E DF NK+ S M + +
Sbjct: 561 IKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEE--MDNFHKKCE 618
Query: 840 ADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
+ L LEL ++ E T+ N L++ + L +E +K + + +Q+ +K
Sbjct: 619 REERLILELGKKV--------EQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK 668
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 110 bits (274), Expect = 8e-24
Identities = 164/839 (19%), Positives = 355/839 (42%), Gaps = 109/839 (12%)
Query: 108 TNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIE 167
TN+ E K + L +LR + NE T + +K +E +++
Sbjct: 437 TNQLESKQSAELNKLRQD-YARLVNELTEKTGKLQQEEVQK--------KNAEQAATQLK 487
Query: 168 SELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDIC 227
+L E V + + K ++ +Q K++ +E+ ++ L H +L D
Sbjct: 488 VQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL------HSKL-TDTL 540
Query: 228 SEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQL------IAQDVTAKN 281
K L + L + E+E++ +N + L+ +++++ ++ +A + Q+ IA +A
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 282 AVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLR----------KEKET 331
++LHK +A++ +Q + + E++ + K E+E D++ ++ +
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----EEELKDIQNMNFLLKAEVQKLQA 656
Query: 332 LEKKLRDANKELEKNTNKI-----------KQLSQEKGRLHQLYETKEGETTRLIREIDK 380
L + A ELEK + +QL E + ++ + L E+ K
Sbjct: 657 LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
Query: 381 LKEDINSHVIK-VKWAQNKLKAEMDSHKETKDKLKET-TTKLTQAKEEADQIRKNCQDMI 438
L+ ++ K V K E D +T ++L ET ++ +EE + IR +
Sbjct: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 439 KTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQL----EMHHAKIKELEDLKRTFKEG 494
K Q+ + +++++ V EL+K + EK ++ E+ A++ ++ + ++T ++
Sbjct: 777 KEVQDLKAKQNDQVSFASLVE--ELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDL 834
Query: 495 MDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGK 554
E++ L+ ++ ++ E+ + SK +E+ N K + + + ++ ++ L
Sbjct: 835 KQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG 894
Query: 555 QEIENLKEEVESLNSLINDL-QKDIEGS-------------RKRESELLLFTERLTSKNA 600
+ +++L+EE ESL + + ++ Q +++ + +++E+EL L + +
Sbjct: 895 KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERES 954
Query: 601 QLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELA 660
L S++ LQ D+ +SQ EQ+KQ N S EEL K ++
Sbjct: 955 DLSSKTQLLQDVQDE----NKLFKSQIEQLKQQNYQQASSFPPHEELLK--------VIS 1002
Query: 661 CRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDK--EVS 718
R+ E+ L +++ LKD + QR+K+ DL ++ +A L E DK + S
Sbjct: 1003 EREKEISGLWNELDSLKDAVEHQRKKN----NDLREKNWEAMEALASTEKMLQDKVNKTS 1058
Query: 719 SMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEK 778
+ + L A+ + P+ + S N + E+ + A +E+
Sbjct: 1059 KERQQQVEAVELEAKEVLKKLFPKVSVPS----NLSYGEWLHGFEKKAKECMAGTSGSEE 1114
Query: 779 IEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSH 838
++ +E +K+ +E TL + K L+ GI+ L S
Sbjct: 1115 VKVLEHKLKE-----------------ADEMHTLLQLECEKYKSVLAETEGILQKLQRSV 1157
Query: 839 PADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
+ ++ ++ + K ++ + + E L++ +IE L + + LE +K
Sbjct: 1158 EQEEN-KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEK 1215
Score = 90.5 bits (223), Expect = 6e-18
Identities = 159/785 (20%), Positives = 332/785 (42%), Gaps = 117/785 (14%)
Query: 110 ETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESE 169
+ +Q +QI + +S E ++ + S+ +++ E+ L++I++
Sbjct: 584 QIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNM 643
Query: 170 LLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQ-----ELFV 224
+ ++ N+ A EK Q Y++ + I +L++E +H+ E F
Sbjct: 644 NFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI--RLLEEQLQHEISNKMEEFK 701
Query: 225 DICSEKDNLREELKKRTE--TEKQHMNTIKQLESRIEELNKEVKASRDQLIA-------- 274
+ + L+ E++K +E+ + + ++Q+E I+E ++++K + L
Sbjct: 702 ILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATK 761
Query: 275 ------------------QDVTAKNAVQ----QLHKEMAQRMEQANKKCEEARQEKEAMV 312
QD+ AK Q L +E+ + + + + K + + EA +
Sbjct: 762 EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAEL 821
Query: 313 MKYVRGEKESLDLRKEKETLEKKLRDANKELEKN-----TNKIKQLSQE-KGRLHQL--- 363
+K EK DL++E + L++++ N +LEK T+K+++L KG+ Q+
Sbjct: 822 LKVANKEKTVQDLKQEIKALKEEI--GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTM 879
Query: 364 ---YETKEGE---TTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSH---------KE 408
E KE + T + ++++ + E + +HV +V AQ+ LK + KE
Sbjct: 880 KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV--AQHNLKEASSASQFEELEIVLKE 937
Query: 409 TKDKLKETTTKLTQAKEEAD---QIRKNCQDMIKTYQES-EEIKS-NELDAKLRVTKGEL 463
+++LK L + + + Q+ ++ QD K ++ E++K N A EL
Sbjct: 938 KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEEL 997
Query: 464 EKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELR--------TLRTKVKCLEDERLRT 515
K + E+ ++ ++ L+D ++ ++LR L + K L+D+ +T
Sbjct: 998 LKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKT 1057
Query: 516 EDELSKYKEIINRQKAEI-QNLLDKVKTADQLQ--EQLQ-------------RGKQEIEN 559
E + E + + E+ + L KV L E L G +E++
Sbjct: 1058 SKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV 1117
Query: 560 LKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSK-NAQLQSESNSLQSQFDKVSC 618
L+ +++ + + LQ + E + +L TE + K ++ E N + + D+
Sbjct: 1118 LEHKLKEADEMHTLLQLECE----KYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173
Query: 619 SESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKD 678
+ Q+QS +Q L S E LR+E + L+ EL + E T+V ELKD
Sbjct: 1174 TIKQMQSSFTSSEQELERLRSENKDIENLRRER-EHLEMELEKAEMERSTYVTEVRELKD 1232
Query: 679 ELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLN-ARSSAE 737
L ++K S + +Q ++ Q+ + K + R +G L+ A+ S E
Sbjct: 1233 LLTELQKKLDDSYSEAVRQNEELNLLKAQLNE-TLTKLRTEQNERQKVAGDLHKAQQSLE 1291
Query: 738 ---DRSPENTGSSVAVDN---FPQVDKA-------MLIERIVRLQKAHARKNEKIEFMED 784
+ + G + ++N P+ + + L + + +LQ+ N+++ ++
Sbjct: 1292 LIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1351
Query: 785 HIKQL 789
H + L
Sbjct: 1352 HYQVL 1356
Score = 87.0 bits (214), Expect = 7e-17
Identities = 191/939 (20%), Positives = 381/939 (40%), Gaps = 134/939 (14%)
Query: 36 SKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCAK----TDTGSENSE 91
+K + E KL+ TDK + + N + E Q + H +S + +D + +
Sbjct: 39 AKQKREQKLIPTKTDKKKAEKKK-NKKKEIQNGNL--HESDSESVPRDFKLSDALAVEDD 95
Query: 92 QIANFPSGNFAKHIS----KTNETEQKVT---QILVELRSSTFPESANEKT----YSESP 140
Q+A P S K E +QK Q++ E +S P E P
Sbjct: 96 QVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPP 155
Query: 141 YDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQD 200
+ +KK + KS + S+D +++E+ ++ ++ E + K E +K
Sbjct: 156 SEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSG--KKKASS 213
Query: 201 KYLQQEHIIKKLIKENKKHQELFVDICSEKDNL-----RE--ELKKRTETEKQHMNTIKQ 253
K + E++ + E H ++ + D+ RE +L K + E + K+
Sbjct: 214 KKQKTENVF---VDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK 270
Query: 254 LESRIEELNKEVK------ASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQE 307
L++ ++ N EVK + + + ++D V L KE + ++ A KK +
Sbjct: 271 LKTETDKENAEVKFKDFLLSLKTMMFSEDEAL--CVVDLLKEKSGVIQDALKKSSKG--- 325
Query: 308 KEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETK 367
E L + + +K L ++ ++ KQL+QE
Sbjct: 326 -------------ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM--------MT 364
Query: 368 EGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEA 427
E E + ++ I ++K+ I + + QNK+ ++ + K ++ ++
Sbjct: 365 EKERSNVV--ITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHL 422
Query: 428 DQIRKNCQDMIK-TYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIK---- 482
Q +D + T + E +S EL+ KLR L ++ EK+ +L+ + K
Sbjct: 423 KQENGILRDAVSNTTNQLESKQSAELN-KLRQDYARLVNELTEKTGKLQQEEVQKKNAEQ 481
Query: 483 -------ELEDLKRTFKEGMDELR-----------TLRTKVKCLEDE----RLRTEDELS 520
+L++ +R ++E +R L++K E+E + D L
Sbjct: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 521 KYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNS----------L 570
+++ R +++ +V + LQ Q+Q ++ E LK +++ +S L
Sbjct: 542 SKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL 601
Query: 571 INDLQKDIEGSRKR----ESELLLFTERLTSKNAQLQSESNS---LQSQFDKVSCSESQL 623
+L K I K+ E L +RLTSK +L+ N L+++ K+ ++
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
Query: 624 QSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDEL--- 680
+ ++++ +S +K++++R E Q LQ E++ + E K L+ Q + LK E+
Sbjct: 662 AAAAHELEKMQ---QSVYVKDDKIRLLEEQ-LQHEISNKMEEFKILNDQNKALKSEVQKL 717
Query: 681 --VTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAED 738
+ + + ++ + K +Q+ KL VE + + + ++ ++ +S+
Sbjct: 718 QTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE-LLETGLIQVATKEEELNAIRTENSSLT 776
Query: 739 RSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTK 798
+ ++ + QV A L+E L+K K+ KI+ +E+ ++ + ++ K K
Sbjct: 777 KEVQD----LKAKQNDQVSFASLVE---ELKKVIHEKDGKIKSVEELLEAELLKVANKEK 829
Query: 799 IIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQA 858
+Q L++E L E V L + + TS + L+ E ++A
Sbjct: 830 TVQD--LKQEIKALKEE---IGNVQLEKAQQLS---ITSKVQELQNLLKGKEEQMNTMKA 881
Query: 859 VLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
VLE+ + LQ L E E L H E+ Q K
Sbjct: 882 VLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLK 920
Score = 62.8 bits (151), Expect = 1e-09
Identities = 110/507 (21%), Positives = 200/507 (39%), Gaps = 67/507 (13%)
Query: 28 NLFSGNESSK------LENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCA 81
NL G E LE + K L+ NT K L E N ++A + H E S A
Sbjct: 867 NLLKGKEEQMNTMKAVLEEKEKDLA-NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925
Query: 82 KTDTGSENSEQIANFPSGNFAKHISKTNETEQKV---TQILVELRSST-FPESANEKTYS 137
E E + + + E E + TQ+L +++ +S E+
Sbjct: 926 SQ---FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ 982
Query: 138 ESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFA-EHRVPNGMNKGE------HA 190
++ +K +S E + + +EL S + A EH+ + E A
Sbjct: 983 QNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEA 1042
Query: 191 LVLFEKCVQDKY---------------LQQEHIIKKL-----IKENKKHQELFVDI---- 226
L EK +QDK L+ + ++KKL + N + E
Sbjct: 1043 LASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKA 1102
Query: 227 --CSEKDNLREELK--KRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNA 282
C + EE+K + E M+T+ QLE E K V A + ++ + + +
Sbjct: 1103 KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC---EKYKSVLAETEGILQK---LQRS 1156
Query: 283 VQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLD---LRKEKETLEKKLRDA 339
V+Q + ++++++K ++ + + + R E+ D LR+E+E LE +L A
Sbjct: 1157 VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKA 1216
Query: 340 NKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQN-K 398
E ++++L L + + E R E++ LK +N + K++ QN +
Sbjct: 1217 EMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNER 1276
Query: 399 LKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRV 458
K D HK + L+ +K+ +A + I + E+E + + L
Sbjct: 1277 QKVAGDLHK-AQQSLELIQSKIVKAAGDTTVIENS-----DVSPETESSEKETMSVSLNQ 1330
Query: 459 TKGELEKQMQEKSDQL--EMHHAKIKE 483
T +L++ +Q + QL E H ++ E
Sbjct: 1331 TVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 110 bits (274), Expect = 8e-24
Identities = 164/839 (19%), Positives = 355/839 (42%), Gaps = 109/839 (12%)
Query: 108 TNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIE 167
TN+ E K + L +LR + NE T + +K +E +++
Sbjct: 437 TNQLESKQSAELNKLRQD-YARLVNELTEKTGKLQQEEVQK--------KNAEQAATQLK 487
Query: 168 SELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQELFVDIC 227
+L E V + + K ++ +Q K++ +E+ ++ L H +L D
Sbjct: 488 VQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL------HSKL-TDTL 540
Query: 228 SEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQL------IAQDVTAKN 281
K L + L + E+E++ +N + L+ +++++ ++ +A + Q+ IA +A
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 282 AVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLR----------KEKET 331
++LHK +A++ +Q + + E++ + K E+E D++ ++ +
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----EEELKDIQNMNFLLKAEVQKLQA 656
Query: 332 LEKKLRDANKELEKNTNKI-----------KQLSQEKGRLHQLYETKEGETTRLIREIDK 380
L + A ELEK + +QL E + ++ + L E+ K
Sbjct: 657 LANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
Query: 381 LKEDINSHVIK-VKWAQNKLKAEMDSHKETKDKLKET-TTKLTQAKEEADQIRKNCQDMI 438
L+ ++ K V K E D +T ++L ET ++ +EE + IR +
Sbjct: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Query: 439 KTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQL----EMHHAKIKELEDLKRTFKEG 494
K Q+ + +++++ V EL+K + EK ++ E+ A++ ++ + ++T ++
Sbjct: 777 KEVQDLKAKQNDQVSFASLVE--ELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDL 834
Query: 495 MDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGK 554
E++ L+ ++ ++ E+ + SK +E+ N K + + + ++ ++ L
Sbjct: 835 KQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG 894
Query: 555 QEIENLKEEVESLNSLINDL-QKDIEGS-------------RKRESELLLFTERLTSKNA 600
+ +++L+EE ESL + + ++ Q +++ + +++E+EL L + +
Sbjct: 895 KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERES 954
Query: 601 QLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELA 660
L S++ LQ D+ +SQ EQ+KQ N S EEL K ++
Sbjct: 955 DLSSKTQLLQDVQDE----NKLFKSQIEQLKQQNYQQASSFPPHEELLK--------VIS 1002
Query: 661 CRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDK--EVS 718
R+ E+ L +++ LKD + QR+K+ DL ++ +A L E DK + S
Sbjct: 1003 EREKEISGLWNELDSLKDAVEHQRKKN----NDLREKNWEAMEALASTEKMLQDKVNKTS 1058
Query: 719 SMGSRSSSSGSLNARSSAEDRSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEK 778
+ + L A+ + P+ + S N + E+ + A +E+
Sbjct: 1059 KERQQQVEAVELEAKEVLKKLFPKVSVPS----NLSYGEWLHGFEKKAKECMAGTSGSEE 1114
Query: 779 IEFMEDHIKQLVEEIRKKTKIIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSH 838
++ +E +K+ +E TL + K L+ GI+ L S
Sbjct: 1115 VKVLEHKLKE-----------------ADEMHTLLQLECEKYKSVLAETEGILQKLQRSV 1157
Query: 839 PADNGLTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
+ ++ ++ + K ++ + + E L++ +IE L + + LE +K
Sbjct: 1158 EQEEN-KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEK 1215
Score = 90.5 bits (223), Expect = 6e-18
Identities = 159/785 (20%), Positives = 332/785 (42%), Gaps = 117/785 (14%)
Query: 110 ETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESE 169
+ +Q +QI + +S E ++ + S+ +++ E+ L++I++
Sbjct: 584 QIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNM 643
Query: 170 LLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKKLIKENKKHQ-----ELFV 224
+ ++ N+ A EK Q Y++ + I +L++E +H+ E F
Sbjct: 644 NFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI--RLLEEQLQHEISNKMEEFK 701
Query: 225 DICSEKDNLREELKKRTE--TEKQHMNTIKQLESRIEELNKEVKASRDQLIA-------- 274
+ + L+ E++K +E+ + + ++Q+E I+E ++++K + L
Sbjct: 702 ILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATK 761
Query: 275 ------------------QDVTAKNAVQ----QLHKEMAQRMEQANKKCEEARQEKEAMV 312
QD+ AK Q L +E+ + + + + K + + EA +
Sbjct: 762 EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAEL 821
Query: 313 MKYVRGEKESLDLRKEKETLEKKLRDANKELEKN-----TNKIKQLSQE-KGRLHQL--- 363
+K EK DL++E + L++++ N +LEK T+K+++L KG+ Q+
Sbjct: 822 LKVANKEKTVQDLKQEIKALKEEI--GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTM 879
Query: 364 ---YETKEGE---TTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSH---------KE 408
E KE + T + ++++ + E + +HV +V AQ+ LK + KE
Sbjct: 880 KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV--AQHNLKEASSASQFEELEIVLKE 937
Query: 409 TKDKLKETTTKLTQAKEEAD---QIRKNCQDMIKTYQES-EEIKS-NELDAKLRVTKGEL 463
+++LK L + + + Q+ ++ QD K ++ E++K N A EL
Sbjct: 938 KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEEL 997
Query: 464 EKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELR--------TLRTKVKCLEDERLRT 515
K + E+ ++ ++ L+D ++ ++LR L + K L+D+ +T
Sbjct: 998 LKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKT 1057
Query: 516 EDELSKYKEIINRQKAEI-QNLLDKVKTADQLQ--EQLQ-------------RGKQEIEN 559
E + E + + E+ + L KV L E L G +E++
Sbjct: 1058 SKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKV 1117
Query: 560 LKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSK-NAQLQSESNSLQSQFDKVSC 618
L+ +++ + + LQ + E + +L TE + K ++ E N + + D+
Sbjct: 1118 LEHKLKEADEMHTLLQLECE----KYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173
Query: 619 SESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKD 678
+ Q+QS +Q L S E LR+E + L+ EL + E T+V ELKD
Sbjct: 1174 TIKQMQSSFTSSEQELERLRSENKDIENLRRER-EHLEMELEKAEMERSTYVTEVRELKD 1232
Query: 679 ELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLN-ARSSAE 737
L ++K S + +Q ++ Q+ + K + R +G L+ A+ S E
Sbjct: 1233 LLTELQKKLDDSYSEAVRQNEELNLLKAQLNE-TLTKLRTEQNERQKVAGDLHKAQQSLE 1291
Query: 738 ---DRSPENTGSSVAVDN---FPQVDKA-------MLIERIVRLQKAHARKNEKIEFMED 784
+ + G + ++N P+ + + L + + +LQ+ N+++ ++
Sbjct: 1292 LIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1351
Query: 785 HIKQL 789
H + L
Sbjct: 1352 HYQVL 1356
Score = 87.0 bits (214), Expect = 7e-17
Identities = 191/939 (20%), Positives = 381/939 (40%), Gaps = 134/939 (14%)
Query: 36 SKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCAK----TDTGSENSE 91
+K + E KL+ TDK + + N + E Q + H +S + +D + +
Sbjct: 39 AKQKREQKLIPTKTDKKKAEKKK-NKKKEIQNGNL--HESDSESVPRDFKLSDALAVEDD 95
Query: 92 QIANFPSGNFAKHIS----KTNETEQKVT---QILVELRSSTFPESANEKT----YSESP 140
Q+A P S K E +QK Q++ E +S P E P
Sbjct: 96 QVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPP 155
Query: 141 YDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQD 200
+ +KK + KS + S+D +++E+ ++ ++ E + K E +K
Sbjct: 156 SEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSG--KKKASS 213
Query: 201 KYLQQEHIIKKLIKENKKHQELFVDICSEKDNL-----RE--ELKKRTETEKQHMNTIKQ 253
K + E++ + E H ++ + D+ RE +L K + E + K+
Sbjct: 214 KKQKTENVF---VDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK 270
Query: 254 LESRIEELNKEVK------ASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQE 307
L++ ++ N EVK + + + ++D V L KE + ++ A KK +
Sbjct: 271 LKTETDKENAEVKFKDFLLSLKTMMFSEDEAL--CVVDLLKEKSGVIQDALKKSSKG--- 325
Query: 308 KEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETK 367
E L + + +K L ++ ++ KQL+QE
Sbjct: 326 -------------ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM--------MT 364
Query: 368 EGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEA 427
E E + ++ I ++K+ I + + QNK+ ++ + K ++ ++
Sbjct: 365 EKERSNVV--ITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHL 422
Query: 428 DQIRKNCQDMIK-TYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIK---- 482
Q +D + T + E +S EL+ KLR L ++ EK+ +L+ + K
Sbjct: 423 KQENGILRDAVSNTTNQLESKQSAELN-KLRQDYARLVNELTEKTGKLQQEEVQKKNAEQ 481
Query: 483 -------ELEDLKRTFKEGMDELR-----------TLRTKVKCLEDE----RLRTEDELS 520
+L++ +R ++E +R L++K E+E + D L
Sbjct: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
Query: 521 KYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVESLNS----------L 570
+++ R +++ +V + LQ Q+Q ++ E LK +++ +S L
Sbjct: 542 SKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL 601
Query: 571 INDLQKDIEGSRKR----ESELLLFTERLTSKNAQLQSESNS---LQSQFDKVSCSESQL 623
+L K I K+ E L +RLTSK +L+ N L+++ K+ ++
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
Query: 624 QSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDEL--- 680
+ ++++ +S +K++++R E Q LQ E++ + E K L+ Q + LK E+
Sbjct: 662 AAAAHELEKMQ---QSVYVKDDKIRLLEEQ-LQHEISNKMEEFKILNDQNKALKSEVQKL 717
Query: 681 --VTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAED 738
+ + + ++ + K +Q+ KL VE + + + ++ ++ +S+
Sbjct: 718 QTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE-LLETGLIQVATKEEELNAIRTENSSLT 776
Query: 739 RSPENTGSSVAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTK 798
+ ++ + QV A L+E L+K K+ KI+ +E+ ++ + ++ K K
Sbjct: 777 KEVQD----LKAKQNDQVSFASLVE---ELKKVIHEKDGKIKSVEELLEAELLKVANKEK 829
Query: 799 IIQSYILREESGTLSSEASDFNKVHLSRRGGIMASLYTSHPADNGLTLELSLEINRKLQA 858
+Q L++E L E V L + + TS + L+ E ++A
Sbjct: 830 TVQD--LKQEIKALKEE---IGNVQLEKAQQLS---ITSKVQELQNLLKGKEEQMNTMKA 881
Query: 859 VLEDTLLKNITLKENLQTLGTEIERLIKHQHELEQRTKK 897
VLE+ + LQ L E E L H E+ Q K
Sbjct: 882 VLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLK 920
Score = 62.8 bits (151), Expect = 1e-09
Identities = 110/507 (21%), Positives = 200/507 (39%), Gaps = 67/507 (13%)
Query: 28 NLFSGNESSK------LENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCA 81
NL G E LE + K L+ NT K L E N ++A + H E S A
Sbjct: 867 NLLKGKEEQMNTMKAVLEEKEKDLA-NTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925
Query: 82 KTDTGSENSEQIANFPSGNFAKHISKTNETEQKV---TQILVELRSST-FPESANEKTYS 137
E E + + + E E + TQ+L +++ +S E+
Sbjct: 926 SQ---FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ 982
Query: 138 ESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFA-EHRVPNGMNKGE------HA 190
++ +K +S E + + +EL S + A EH+ + E A
Sbjct: 983 QNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEA 1042
Query: 191 LVLFEKCVQDKY---------------LQQEHIIKKL-----IKENKKHQELFVDI---- 226
L EK +QDK L+ + ++KKL + N + E
Sbjct: 1043 LASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKA 1102
Query: 227 --CSEKDNLREELK--KRTETEKQHMNTIKQLESRIEELNKEVKASRDQLIAQDVTAKNA 282
C + EE+K + E M+T+ QLE E K V A + ++ + + +
Sbjct: 1103 KECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC---EKYKSVLAETEGILQK---LQRS 1156
Query: 283 VQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLD---LRKEKETLEKKLRDA 339
V+Q + ++++++K ++ + + + R E+ D LR+E+E LE +L A
Sbjct: 1157 VEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKA 1216
Query: 340 NKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQN-K 398
E ++++L L + + E R E++ LK +N + K++ QN +
Sbjct: 1217 EMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNER 1276
Query: 399 LKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRV 458
K D HK + L+ +K+ +A + I + E+E + + L
Sbjct: 1277 QKVAGDLHK-AQQSLELIQSKIVKAAGDTTVIENS-----DVSPETESSEKETMSVSLNQ 1330
Query: 459 TKGELEKQMQEKSDQL--EMHHAKIKE 483
T +L++ +Q + QL E H ++ E
Sbjct: 1331 TVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.123 0.317
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,502,401
Number of Sequences: 37866
Number of extensions: 1349735
Number of successful extensions: 26631
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 592
Number of HSP's successfully gapped in prelim test: 1382
Number of HSP's that attempted gapping in prelim test: 8021
Number of HSP's gapped (non-prelim): 7610
length of query: 898
length of database: 18,247,518
effective HSP length: 111
effective length of query: 787
effective length of database: 14,044,392
effective search space: 11052936504
effective search space used: 11052936504
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.