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Search of human proteins with 34878904
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
(976 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 1892 0.0
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 149 1e-35
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 143 9e-34
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 143 9e-34
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 142 1e-33
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 141 3e-33
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 139 2e-32
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 136 8e-32
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 136 8e-32
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 136 8e-32
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 136 8e-32
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 134 3e-31
gi|4506751 restin isoform a [Homo sapiens] 133 9e-31
gi|156104908 myosin heavy chain 6 [Homo sapiens] 132 2e-30
gi|55770834 centromere protein F [Homo sapiens] 131 3e-30
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 131 4e-30
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 131 4e-30
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 130 8e-30
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 129 1e-29
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 127 4e-29
gi|58530840 desmoplakin isoform I [Homo sapiens] 127 5e-29
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 127 7e-29
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 127 7e-29
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 126 9e-29
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 126 9e-29
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 126 9e-29
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 125 3e-28
gi|38044112 restin isoform b [Homo sapiens] 125 3e-28
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 124 3e-28
gi|118498368 kinectin 1 isoform c [Homo sapiens] 124 4e-28
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 1892 bits (4901), Expect = 0.0
Identities = 976/976 (100%), Positives = 976/976 (100%)
Query: 1 MEKQKPFALFVPPRSSSSQVSAVKPQTLGGDSTFFKSFNKCTEDDFEFPFAKTNLSKNGE 60
MEKQKPFALFVPPRSSSSQVSAVKPQTLGGDSTFFKSFNKCTEDDFEFPFAKTNLSKNGE
Sbjct: 1 MEKQKPFALFVPPRSSSSQVSAVKPQTLGGDSTFFKSFNKCTEDDFEFPFAKTNLSKNGE 60
Query: 61 NIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWK 120
NIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWK
Sbjct: 61 NIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWK 120
Query: 121 VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR 180
VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR
Sbjct: 121 VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR 180
Query: 181 HLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMH 240
HLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMH
Sbjct: 181 HLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMH 240
Query: 241 FKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE 300
FKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE
Sbjct: 241 FKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE 300
Query: 301 EKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKE 360
EKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKE
Sbjct: 301 EKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKE 360
Query: 361 TQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELE 420
TQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELE
Sbjct: 361 TQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELE 420
Query: 421 EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHD 480
EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHD
Sbjct: 421 EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHD 480
Query: 481 LEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLE 540
LEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLE
Sbjct: 481 LEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLE 540
Query: 541 LKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEEN 600
LKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEEN
Sbjct: 541 LKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEEN 600
Query: 601 CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEI 660
CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEI
Sbjct: 601 CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEI 660
Query: 661 TDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ 720
TDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ
Sbjct: 661 TDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ 720
Query: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE
Sbjct: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKRE 780
Query: 781 AKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLW 840
AKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLW
Sbjct: 781 AKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLW 840
Query: 841 TSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDL 900
TSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDL
Sbjct: 841 TSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDL 900
Query: 901 LSMVSEEETLKTLYRNNNPPASHLCVKTPKKAPSSLTTPGSTLKFGAIRKMREDRWAVIA 960
LSMVSEEETLKTLYRNNNPPASHLCVKTPKKAPSSLTTPGSTLKFGAIRKMREDRWAVIA
Sbjct: 901 LSMVSEEETLKTLYRNNNPPASHLCVKTPKKAPSSLTTPGSTLKFGAIRKMREDRWAVIA 960
Query: 961 KMDRKKKLKEAEKLFV 976
KMDRKKKLKEAEKLFV
Sbjct: 961 KMDRKKKLKEAEKLFV 976
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 149 bits (377), Expect = 1e-35
Identities = 186/830 (22%), Positives = 373/830 (44%), Gaps = 118/830 (14%)
Query: 111 KEAEKIKKWKVSTEAELRQKESKLQ---ENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQ 167
+E K+K+ + E EL + E K Q E + I+ Q +A EL E++ +L Q
Sbjct: 859 EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918
Query: 168 ENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEE 227
E ++++ + L+ E+ + + E+++ + DL +++ A ++
Sbjct: 919 ELEEILHD----------LESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK 968
Query: 228 LRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDK---EKQVSLLLIQITEKENKMKD 284
L+++ ++ K+K+ E+I LE + K I +K E +++ Q+ E+E K K+
Sbjct: 969 LQLE----KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 285 LTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHL----TKELEDIKVSLQRSVSTQK- 339
L + + ++ LEE+ K + E +Q +EK T +L+D LQ + K
Sbjct: 1025 LAKIRNKQEVMISDLEERLK-KEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083
Query: 340 ---ALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQ 396
EE+LQ A L + + ++N + VV E + + L+E +E+
Sbjct: 1084 QLAKKEEELQGA------LARGDDETLHKNNALK-----VVRELQAQIAELQEDFESEKA 1132
Query: 397 RLEKNEDQLKILTMELQKKSSELEE-------MTKLTNNKEVELEELKKVLGEKETLLYE 449
K E Q + L+ EL+ +ELE+ +L +E E+ ELKK L E+ET +E
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL-EEETKNHE 1191
Query: 450 NKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVK---DLKTEL 506
Q + + + +EL L+ ++ +LE + T + + EVK +K E
Sbjct: 1192 -AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 507 ENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN-NKKQEERMLKQIENL 565
E+++ K + E L E ++ +L+N+ ++++ ++ E++ +K ++
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 566 QETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKAL 625
E+QL++ E ++EE +QK + + ++ + EE N+L++Q E + + + L+++ AL
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLAL 1369
Query: 626 KKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKA 685
+ + K++ + + +E LE AK+K + + + +E+K ++ + L EK
Sbjct: 1370 QSQLADTKKKV---DDDLGTIE-SLEEAKKKLLKDAEALSQRLEEKALAYDKL----EKT 1421
Query: 686 KVIADEAVKLQKEIDK---RCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQ 742
K +LQ+E+D H+ ++ + +EK + ++D+++ E S Y +
Sbjct: 1422 K------NRLQQELDDLTVDLDHQ-RQVASNLEKKQKKFDQLLAEEKSISARYAEE---- 1470
Query: 743 SSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLE 802
R E E + + LS+ + LE E KE+ +R+ K+ A +++ K
Sbjct: 1471 ---RDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSK------- 1520
Query: 803 TPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTK 862
V +N H + K KR L + + T +
Sbjct: 1521 ---------------DDVGKNV----HELEKSKR---------ALEQQVEEMRTQLEELE 1552
Query: 863 PKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTD----LLSMVSEEE 908
+LQ E+ + +E + + K FE D+ + + + L+ V E E
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELE 1602
Score = 120 bits (300), Expect = 8e-27
Identities = 164/779 (21%), Positives = 335/779 (43%), Gaps = 109/779 (13%)
Query: 52 KTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYK 111
K NL KN + +++D + + VL+QV H ++ L D + E ++V
Sbjct: 1219 KANLEKNKQGLETDNK-ELACEVKVLQQVKAESEHKRKKL---DAQVQELHAKV-----S 1269
Query: 112 EAEKIKKWKVSTEAELRQKESKLQENRKII-----EAQRKAIQELQFGNEKVSLKLEEGI 166
E ++++ EL +K SKLQ + EA++K I+ F + SL E +
Sbjct: 1270 EGDRLR-------VELAEKASKLQNELDNVSTLLEEAEKKGIK---FAKDAASL--ESQL 1317
Query: 167 QENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFE 226
Q+ ++L++E TR NL EK E + EE + N+EK + A +
Sbjct: 1318 QDTQELLQEE--TRQKLNLSSRIRQLEEEKNSLQEQQEEEE-----EARKNLEKQVLALQ 1370
Query: 227 ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE------KQVSLLLIQITEKEN 280
+ K+ +D I+ LE+ KK + D E ++ +L ++ + +N
Sbjct: 1371 SQLADTKK-------KVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423
Query: 281 KMK----DLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQ---- 332
+++ DLT L+ R + LE+K K + L + +E + + +
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKET 1483
Query: 333 RSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLR 392
+++S +ALEE L+ A + + ++ ME+ ++ V E E + +LE+ +
Sbjct: 1484 KALSLARALEEALE-AKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVE 1542
Query: 393 TEQQRLEKNEDQLKI---------LTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEK 443
+ +LE+ ED+L+ + M+ K E + T+ N+E +K
Sbjct: 1543 EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEE-----------KK 1591
Query: 444 ETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLK 503
L+ + ++ E E+ + + + E ++ DLE Q+ A + K+++ L+
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651
Query: 504 TELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKK-------QEE 556
++++ + + E + +++ ++KE ++ + E+ QE++ ++++ + +
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 557 RMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIE 616
+ +I N ++ L +E + + Q +E++ + E + RK +
Sbjct: 1712 ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771
Query: 617 ELQQENKALKKKGTAESK-QLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISE 675
EL E A +K A + + E+K ELE + K KF + +I
Sbjct: 1772 ELAAERSAAQKSDNARQQLERQNKELKAKLQELE-GAVKSKFKATISALEAKIGQL---- 1826
Query: 676 ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALME---KHKHQYDKIIEERDSEL 732
E LE+ K + A++ V +R + K+ E+ +E +H QY + +E+ ++ +
Sbjct: 1827 EEQLEQEAKERAAANKLV-------RRTEKKLKEIFMQVEDERRHADQYKEQMEKANARM 1879
Query: 733 GLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEK 791
K + +E E E + A ++++L+ E E L RE +TLK +
Sbjct: 1880 KQLKRQLEE-------AEEEATRANASRRKLQRELDDATEANEGLSRE----VSTLKNR 1927
Score = 117 bits (293), Expect = 5e-26
Identities = 153/750 (20%), Positives = 336/750 (44%), Gaps = 71/750 (9%)
Query: 97 ENSEGLSRVYSK---LYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQF 153
E ++ L+++ +K + + E+ K + T EL + + KL ++ Q I ELQ
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ---IAELQA 1076
Query: 154 GNEKVSLKLEEGIQENKD-LIKENNATRHLCNLLK---ETCARSAEKTKKYEYE---REE 206
+++ L+L + +E + L + ++ T H N LK E A+ AE + +E E R +
Sbjct: 1077 QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNK 1136
Query: 207 TRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQH-LEQEYKK---EIN 262
+ DL+ +E + T E+ + ++ E+ K +++ +++ LE+E K +I
Sbjct: 1137 AEKQKRDLSEELEALKTELEDT-LDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQ 1195
Query: 263 DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTK 322
D ++ + L +++E+ + K LE+++ + ++ + + L+Q + H K
Sbjct: 1196 DMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRK 1255
Query: 323 ELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFET 382
+L+ L VS L +L + + T +EE+ K + E+
Sbjct: 1256 KLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315
Query: 383 TVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGE 442
+ +ELL+ E ++ +++ L E + EE + N E ++ L+ L +
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLAD 1375
Query: 443 KETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDL 502
+ + ++ E L+ +++L+ +A + + + + + ++ +E+ DL
Sbjct: 1376 TKKKVDDDL---GTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL 1432
Query: 503 KTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEE------ 556
+L++++ ++ S+ K + +L E ++ +++ +++E
Sbjct: 1433 TVDLDHQR----QVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSL 1488
Query: 557 -RMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYI 615
R L++ +E + +L E+L +D+V + + E++ L +QVE +
Sbjct: 1489 ARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQL 1548
Query: 616 EELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKK--- 672
EEL+ E +A T ++K +LE+ +++ K +F T ++ E+KK
Sbjct: 1549 EELEDELQA-----TEDAKL---------RLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 673 ---ISE-ENLLEEVEKAKVIADEAVKLQKEID-----------KRCQHKIAEMVALMEKH 717
+ E E LE+ K + +A A K + EID + + ++ + + ++
Sbjct: 1595 IKQVRELEAELEDERKQRALA-VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653
Query: 718 KHQYDKIIEE-RDSELGLYKSKEQEQSSLRASLEIELSNLKAELLS---VKKQLEIEREE 773
Y + +EE R S ++ ++ + L+ SLE E+ L+ EL S ++ E ER+E
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLK-SLEAEILQLQEELASSERARRHAEQERDE 1712
Query: 774 -KEKLKREAKENTATLKEKKDKKTQTFLLE 802
+++ A +A L EK+ + + LE
Sbjct: 1713 LADEITNSASGKSALLDEKRRLEARIAQLE 1742
Score = 102 bits (255), Expect = 1e-21
Identities = 128/637 (20%), Positives = 271/637 (42%), Gaps = 117/637 (18%)
Query: 295 KVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQ 354
+V + EE+ + + E L + EKQ + ELE+++ Q+ + + L E LQ T+ +
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 355 LTE---------------------------------------------EKETQMEESNKA 369
E + E Q++E A
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 370 RAAHSFVVTEFETTVCSLEE---LLRTEQQRLEKN----EDQLKILTMELQKKSSELEEM 422
R E + +EE LL + + K ED++ + +L ++ + + +
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 423 TKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLE 482
K+ N +EV + +L++ L ++E ++ EK +L G +L + + ++ +L+
Sbjct: 1026 AKIRNKQEVMISDLEERLKKEEK---TRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082
Query: 483 IQLT--------AITTSE-------------QYYSKEVKDLKTELENEKLKNTELTSHCN 521
+QL A+ + + ++ +L+ + E+EK +
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 522 KLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQI--ENLQETETQLRN----- 574
LS E + L E D TL+ Q+++ ++QE LK+ E + E Q+++
Sbjct: 1143 DLSEELEALKTELED-TLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRH 1201
Query: 575 --ELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAE 632
LE + E+L+Q + K L+K+++ K++ + K +++++ E++ +KK A+
Sbjct: 1202 ATALEELSEQLEQAK-RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1260
Query: 633 SKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKV-IADE 691
++L+ + ++L +EL K Q E++ + LLEE EK + A +
Sbjct: 1261 VQELHAKVSEGDRLRVELAEKASKL-------QNELD----NVSTLLEEAEKKGIKFAKD 1309
Query: 692 AVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEI 751
A L+ ++ E++ + K I + + E + +++E+ R +LE
Sbjct: 1310 AASLESQL-----QDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364
Query: 752 ELSNLKAELLSVKKQ-------LEIEREEKEKLKREAKENTATLKEK-----KDKKTQTF 799
++ L+++L KK+ +E E K+KL ++A+ + L+EK K +KT+
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR 1424
Query: 800 L-LETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDK 835
L E ++ LD + + + + D ++++K
Sbjct: 1425 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK 1461
Score = 92.8 bits (229), Expect = 1e-18
Identities = 95/511 (18%), Positives = 223/511 (43%), Gaps = 48/511 (9%)
Query: 98 NSEGLSRVYSKLYKEAEKIK----KWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQF 153
N E + + +L E + I + + EAE R+KE+K + +E +A +E +
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFER 1504
Query: 154 GNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMD 213
N+++ +E+ + D+ K + L++ + ++ E E + T +
Sbjct: 1505 QNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLR 1564
Query: 214 LNNNIEKMITAFE-ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLL 272
L N++ M FE +L+ + E + + +K+ +E + E+ D+ KQ +L +
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQ--------VRELEAELEDERKQRALAV 1616
Query: 273 IQITEKENKMKDLTFLLE---ESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKV 329
+ E +KDL +E ++RD+V + K + Q ++ ++ +E+ E+
Sbjct: 1617 ASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK 1676
Query: 330 SLQRSVSTQKA----LEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTE---FET 382
++ + + +A L+E+L + + +E++ +E + + S ++ E E
Sbjct: 1677 ESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEA 1736
Query: 383 TVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGE 442
+ LEE L EQ +E D+ + T+++ ++EL + ++L++
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLER---- 1792
Query: 443 KETLLYENKQFEKIAEELKGT-EQELIGLLQAREKEVHDLEIQL-------TAITTSEQY 494
+NK+ + +EL+G + + + A E ++ LE QL A +
Sbjct: 1793 ------QNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRR 1846
Query: 495 YSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
K++K++ ++E+E+ + K + K+L + +L+ +E+
Sbjct: 1847 TEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKR-------QLEEAEEEATRANAS 1899
Query: 555 EERMLKQIENLQETETQLRNELEYVREELKQ 585
++ +++++ E L E+ ++ L++
Sbjct: 1900 RRKLQRELDDATEANEGLSREVSTLKNRLRR 1930
Score = 41.6 bits (96), Expect = 0.004
Identities = 43/253 (16%), Positives = 107/253 (42%), Gaps = 11/253 (4%)
Query: 126 ELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNL 185
E R+ E+++ + + +E ++ ++ L K +L+++ N +L E +A + N
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT---LNAELAAERSAAQKSDNA 1786
Query: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE 245
++ ++ E K + + + + +E I EE Q R + ++
Sbjct: 1787 RQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRR 1846
Query: 246 DYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKL 305
+K++ E ++ D+ + Q+ + +MK L LEE+ ++ + +
Sbjct: 1847 TEKKLK----EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRK 1902
Query: 306 QSENLKQSIEKQHHLTKELEDIKVSLQR----SVSTQKALEEDLQIATKTICQLTEEKET 361
L + E L++E+ +K L+R S S+ ++ L + ++ ++ E+
Sbjct: 1903 LQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTES 1962
Query: 362 QMEESNKARAAHS 374
+ + N+ + S
Sbjct: 1963 KTSDVNETQPPQS 1975
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 143 bits (360), Expect = 9e-34
Identities = 191/851 (22%), Positives = 375/851 (44%), Gaps = 100/851 (11%)
Query: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDL---IKENNATR 180
E E Q ++KL + + RK I+EL N + + ++ + E+ L +++ + T
Sbjct: 381 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 440
Query: 181 HLC-----NLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMI-TAFEELRVQAEN 234
L +L E ++ + K E E + + +L ++ + A + L+++ EN
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
Query: 235 SRLEMHFKL--------KEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLT 286
RL ++ K+ + Q+L ++ KE EK + L +EN + +
Sbjct: 501 QRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL------RENSERQIK 554
Query: 287 FLLEESR---DKVNQLEEKTKLQSENLKQSIEKQHHLTKE-LEDIKVSLQRSVSTQKALE 342
L +E+ V+ L +++++ +E + IEK++ + E +++ L + ++ ++
Sbjct: 555 ILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614
Query: 343 EDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL------LRTEQQ 396
++L+ K + EE E ++ K +T + T +E L L E +
Sbjct: 615 KELE-HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENR 673
Query: 397 RLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKI 456
+L+K D K LT +L+ E ++ + +E LK + L ENK+ E
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733
Query: 457 AEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTEL 516
E+LK + + LL+A K+ LE+ + Q K LEN K +L
Sbjct: 734 KEQLK----KGLELLKASFKKTERLEVSYQGLDIENQRLQKT-------LENSNKKIQQL 782
Query: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNEL 576
S L +EN+ L + E++ + K+ E++ K+ ++L++ +QL +
Sbjct: 783 ESELQDLEMENQTLQKNL-----------EELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 577 EYVREELKQKRDEVKCKLDKSEEN---CNNLRKQVENKNKYI----------EELQQENK 623
+ + +E K+ R + + K EEN NL K+ + +K I +EL++ENK
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 624 ALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQK---EIEDKKISEENLLE 680
L K+ T + K L L +L S K K ++ + +K E+E +++E LL
Sbjct: 892 ELVKRATIDIKTLVT-------LREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 681 EVEKA----KVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLY- 735
+ + K++ + K+ + + KIA + A +E+ + ++ +E + Y
Sbjct: 945 DEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE 1004
Query: 736 --KSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLK-EKK 792
K ++ E+ +++S I + K E S + E+ + + + E + N ATL+ EK+
Sbjct: 1005 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI--EVERNNATLQAEKQ 1062
Query: 793 DKKTQTFLLETPEIYWKLDSKAVPSQTVS---RNFT----SVDHGISKDKRDYLWTSAKN 845
KTQ LET + A+ QTVS +N T + + + TS N
Sbjct: 1063 ALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN 1122
Query: 846 TLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSMVS 905
+ L + +++ + +++RE+L + +S K E +SE S++S
Sbjct: 1123 QNAQLLIQQSSLENENESVIKEREDLK-SLYDSLIKDHEKLELLHERQASEYE---SLIS 1178
Query: 906 EEETLKTLYRN 916
+ TLK+ ++N
Sbjct: 1179 KHGTLKSAHKN 1189
Score = 136 bits (342), Expect = 1e-31
Identities = 225/998 (22%), Positives = 423/998 (42%), Gaps = 181/998 (18%)
Query: 126 ELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNL 185
EL ++K++ R+ +E + + + + + E++ ++L+ QEN +L+ + + R +
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE 245
L + A + K E E ++ D+ F + RV+ +LKE
Sbjct: 312 L-DALREKAVRVDKLESEVSRYKERLHDIE---------FYKARVE----------ELKE 351
Query: 246 DYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKEN-----KMKDLTFLLEESRDKVNQLE 300
D + + + + ++ + L EKEN K+ D+ + R K+ +L
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKL--HELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
Query: 301 EKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKA---------------LEEDL 345
E+ KQS+++ HL ELE I + + S + QK+ LE +
Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
Query: 346 QIATKTICQL---------TEEKETQMEESN-----KARAAHSFVVTEFET--TVCSLEE 389
Q TKT+ +L K +ME+ N K + +V E ++ +L +
Sbjct: 470 QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529
Query: 390 LLRTEQQRLEK--------NEDQLKILTME---LQKKSSELEEMTKLTNNKEV-ELEELK 437
L E+ +LEK +E Q+KIL E L + S L + ++++ V ++E+
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 438 KVLGE--KET------LLYENKQFEKIAEELK---GTEQELIGLLQAREKEVHDLEIQLT 486
K+L E KET + +E +Q +K E K +EL L EKE L+ ++T
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649
Query: 487 AI-TTSEQYYSKEVKDLKTELENEKLKNT-----ELTSHCNKLSLENKELTQETSDMTLE 540
+ T E+ + E ++ + E EN KLK T LT L EN +L +E LE
Sbjct: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE----NLE 705
Query: 541 LKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEEN 600
L+ E + + ++ + + L+ + QL+ LE ++ K K + ++ +
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK-KTERLEVSYQGLDIE 764
Query: 601 CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEI---KVNKLELELESAKQKF 657
L+K +EN NK I++L+ E + L+ + K L +I ++ +LE E +S +Q+
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824
Query: 658 GEITD------------TYQKEIEDKKISEENL----LEEVEK-----------AKVIAD 690
++ Q EI+D + E N+ LE+ K + V
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
Query: 691 EAVKLQKEIDKRCQHKIAEMVAL-----------------MEKHKHQYDKI-------IE 726
E K KE+ KR I +V L +EK H+ +KI +
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 727 ERDSELGLYKSKEQE-QSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENT 785
+ S YK E + +S+L+ SLEI+ + A +++ ++ +++LK K+N
Sbjct: 945 DEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK-TVKKNY 1003
Query: 786 ATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSV-DHGISKDKRDYLWTSAK 844
LK+++D+ + + +P I + + SQ +R V D I ++ + + K
Sbjct: 1004 EALKQRQDE--ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
Query: 845 NTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESK---KKRKMAFEFDINSDSSETTDLL 901
L T L + T + ++ + + ++E + + + + ++ +S++T L+
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
Query: 902 ------------------SMVSEEETLKTLYRNNNPPASHLCVKTPKKAP--SSLTTPGS 941
S++ E E LK+LY + L + ++A SL +
Sbjct: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1181
Query: 942 TLK-----FGAIRKMREDRWAVIAKMDRKKKLKEAEKL 974
TLK + EDR+ + K +K +L++ EK+
Sbjct: 1182 TLKSAHKNLEVEHRDLEDRYNQLLK--QKGQLEDLEKM 1217
Score = 134 bits (336), Expect = 5e-31
Identities = 194/873 (22%), Positives = 397/873 (45%), Gaps = 93/873 (10%)
Query: 91 LKDSDLENS---EGLSRVYSKLYK---EAEKIKKWKVSTEAELRQKESKLQENRKIIEAQ 144
+KD + EN E + SKL K E +IKK ++ E ++ +L+ +E +
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKK-ELEHYKEKGERAEELENELHHLEKE 640
Query: 145 RKAIQELQFGNEKVSL-KLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYE 203
+ +Q+ + N K++ K+E QEN +L +EN + + K + + E E
Sbjct: 641 NELLQK-KITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ----LESLEKE 695
Query: 204 REETRQVYMDLNNNIEKMITAFEEL-RVQAENSRLEMHFKLKEDYEK-IQHLEQEYKKEI 261
+ + ++L N+E + A ++ ++Q EN LE KE +K ++ L+ +KK
Sbjct: 696 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE---KEQLKKGLELLKASFKKT- 751
Query: 262 NDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK---LQSENLKQSIEKQH 318
+ +VS + I EN+ T LE S K+ QLE + + ++++ L++++E+
Sbjct: 752 --ERLEVSYQGLDI---ENQRLQKT--LENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
Query: 319 HLTKELEDIKV---SLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESN-------K 368
+K LE ++ SL++ S + ++ L+ K + Q E K+T +EE+N K
Sbjct: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
Query: 369 ARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNN 428
S + ++ + L+EL + ++ +++ +K L + SE + ++ N+
Sbjct: 865 ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924
Query: 429 KEVELEELKKVLGEKETLLYENKQFEKIAEELKGT-EQELIGLLQAREKEVHDLEIQLTA 487
E EL+K+ KE LL++ + + + L+ E L L+ +E+++ LE +L
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 984
Query: 488 ITTSEQYYSKEVKDLKTELENEKLKNTE---------LTSHCNKLSLENKELTQE---TS 535
T Q +E+K +K E K + E ++ NK E++E T+E
Sbjct: 985 STNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVK 1044
Query: 536 DMTLELKNQQEDINNNKKQEERMLKQIE----NLQETETQLRNELEYVREE-LKQKRDEV 590
D +E++ + K+ + LKQ+E NLQ L+ + ++E+ +
Sbjct: 1045 DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNA 1104
Query: 591 KCKLDKSEENCNNLRKQVENKNKYIEE--LQQENKALKKKGTAESKQLNVYEIKVN-KLE 647
K +++ S N + +N I++ L+ EN+++ K+ + K L IK + KLE
Sbjct: 1105 KLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE-REDLKSLYDSLIKDHEKLE 1163
Query: 648 L-------ELESAKQKFGEITDTYQ------KEIEDKK---ISEENLLEEVEKAKVIADE 691
L E ES K G + ++ +++ED+ + ++ LE++EK + E
Sbjct: 1164 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQE 1223
Query: 692 AVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEI 751
+ L+ + + + ++ ++ H Y ++++E + + ++ + SL + ++
Sbjct: 1224 KMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE----VLQTDHKNLKSLLNNSKL 1279
Query: 752 ELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLD 811
E + L+AE +K+Q + KL + E + LK +++ + L + + L
Sbjct: 1280 EQTRLEAEFSKLKEQYQQLDITSTKLNNQC-ELLSQLKGNLEEENRHLLDQIQTL--MLQ 1336
Query: 812 SKAVPSQTV-SRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPK------ 864
++ + Q + S++ V+ DK + L K L + Y P+ P+
Sbjct: 1337 NRTLLEQNMESKDLFHVEQRQYIDKLNEL-RRQKEKLEEKIMDQYKFYDPSPPRRRGNWI 1395
Query: 865 -LQQRENLNIPIEESKKKRKMAFEFDINSDSSE 896
L+ R+ + + +++++K SDSSE
Sbjct: 1396 TLKMRKLIKSKKDINRERQKSLTLTPTRSDSSE 1428
Score = 122 bits (307), Expect = 1e-27
Identities = 185/763 (24%), Positives = 335/763 (43%), Gaps = 123/763 (16%)
Query: 96 LENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKL--QENRKIIEAQRKAIQELQF 153
L+N + LS+ L KE +++K + T E +++ K+ QEN + + Q Q
Sbjct: 521 LQNCQNLSK---DLMKEKAQLEK-TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQI 576
Query: 154 GNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMD 213
E KD+ KEN +L E+ ++ K K E+E+ RQ+ +
Sbjct: 577 SAEA----------RVKDIEKENK-------ILHESIKETSSKLSKIEFEK---RQIKKE 616
Query: 214 LNNNIEKMITAFEELR-----VQAENSRLEMHF-KLKEDYEKIQHLEQEYKKEINDKEKQ 267
L + EK A EEL ++ EN L+ LK EKI+ LEQE E+ + ++
Sbjct: 617 LEHYKEKGERA-EELENELHHLEKENELLQKKITNLKITCEKIEALEQE-NSELERENRK 674
Query: 268 VSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT---KLQSENLKQSIEKQHHL---T 321
+ L + K+LTF LE + +QL+E+ + E+LK + K L
Sbjct: 675 LKKTL-------DSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 322 KELEDIKVSLQRSVSTQKAL---EEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
KELE K L++ + KA E L+++ + + + + +E SNK +
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK-------IQ 780
Query: 379 EFETTVCSLEELLRTEQQRLEKNEDQLKILTM---ELQKKSSELEEMTKLTNNKEVELEE 435
+ E+ + LE E Q L+KN ++LKI + +L+K++ LE+ T + +LE+
Sbjct: 781 QLESELQDLE----MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK 836
Query: 436 LKKVLGE----KETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTS 491
K L + K+T L EN E+ T + IG+ + + +LE + +
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 492 EQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLE------NKEL----TQETSDMTLEL 541
K + L+ +L +EKLK ++ + KL+ E NKE Q T D L
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL 956
Query: 542 KNQQED-INNNKKQEERMLKQIENLQETET----QLRNELEYVR---EELKQKRDE---- 589
+++ E + + + +E + +E E T QLR EL+ V+ E LKQ++DE
Sbjct: 957 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1016
Query: 590 -----VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVN 644
+ + +K E +++ + E+++ N L+ + A QL E + N
Sbjct: 1017 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1076
Query: 645 KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQ 704
L+ ++ + ++ + + E+N + + AK+ + + + Q
Sbjct: 1077 NLQAQILALQR-------------QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1123
Query: 705 HKIAEMVALMEKHKHQYDKIIEERDSELGLYKS--KEQEQSSL----RASLEIELSNLKA 758
+ A+++ +++ + +I+ER+ LY S K+ E+ L +AS L +
Sbjct: 1124 N--AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1181
Query: 759 ELLSVKKQLEIEREEKE-------KLKREAKENTATLKEKKDK 794
L S K LE+E + E K K + ++ LK +++K
Sbjct: 1182 TLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1224
Score = 80.1 bits (196), Expect = 9e-15
Identities = 109/494 (22%), Positives = 229/494 (46%), Gaps = 53/494 (10%)
Query: 325 EDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTV 384
EDI+ L+ K L ++ ++TI +L+EE++ + + +A S
Sbjct: 184 EDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQS---------P 234
Query: 385 CSLEELLRTEQQR-----LEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKV 439
C + RTE ++ L + +++ L EL++K+ +L + + E+EL+ L++
Sbjct: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ- 293
Query: 440 LGEKETLLYENKQFEKIAEELKGTEQELIGL------LQAREKEVHDLEIQLTAITTSEQ 493
E LL + + +EL ++ + + + ++ +HD+E + ++
Sbjct: 294 --ENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351
Query: 494 YYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKK 553
++ + + KT LE++ + ++L EN +L + DM +E + ++K
Sbjct: 352 -DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER-------DMDRK 403
Query: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQV-ENKN 612
+ E ++++ L+ + Q +E ++ EL+Q + + SE +L +V E +
Sbjct: 404 KIEELMEENMTLEMAQKQSMDESLHLGWELEQ----ISRTSELSEAPQKSLGHEVNELTS 459
Query: 613 KYIEELQQENKALKKKGTAESKQLNVYEIKVNKLE-LELESAKQKFGEITDTYQKEIEDK 671
+ +L+ EN++L K T E + V ++ N + L++E Q+ + + + EI +
Sbjct: 460 SRLLKLEMENQSLTK--TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 672 KISE---ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEER 728
K S +NL +++ K K ++ ++ +E +R Q KI E +H +Q + +R
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER-QIKILEQ---ENEHLNQTVSSLRQR 573
Query: 729 D--SELGLYKSKEQEQSSLRASLE---IELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
S K E+E L S++ +LS ++ E +KK+LE +E+ E + E E
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE--RAEELE 631
Query: 784 NTATLKEKKDKKTQ 797
N EK+++ Q
Sbjct: 632 NELHHLEKENELLQ 645
Score = 78.2 bits (191), Expect = 4e-14
Identities = 108/509 (21%), Positives = 205/509 (40%), Gaps = 81/509 (15%)
Query: 89 EGLKDSDLENS-EGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQEN-RKIIEAQRK 146
E LK + N E L+ K+ E++ + ST+ + ESKL+ +K +E + +
Sbjct: 914 EKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEE 973
Query: 147 AIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLK-----ETCARSAE----KT 197
I L+ +LEE N+ L +E + LK E +S+ +
Sbjct: 974 KIAALE-------ARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED 1026
Query: 198 KKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEY 257
K+E E +ET + + + + + + V+ N+ L+ +Q
Sbjct: 1027 NKWERESQETTRELLKVKDRL---------IEVERNNATLQAE-------------KQAL 1064
Query: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQ 317
K ++ E Q + L QI L R V+ E+ T LQ++N K +E
Sbjct: 1065 KTQLKQLETQNNNLQAQI-------------LALQRQTVSLQEQNTTLQTQNAKLQVENS 1111
Query: 318 HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVV 377
++ + + Q + Q +LE + + K L ++ +++ K H
Sbjct: 1112 TLNSQSTSLMNQNAQLLIQ-QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1170
Query: 378 TEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKL-----------T 426
+E+E+ + S L++ + LE L+ +L K+ +LE++ K+
Sbjct: 1171 SEYESLI-SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1229
Query: 427 NNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLT 486
N E E KK+ GE + L + Q K E L+ + L LL + E LE + +
Sbjct: 1230 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS 1289
Query: 487 AITTSEQYYSKEVKDLKTELENEKL---------KNTELTSHCNKLSLENKELTQETSD- 536
+ EQY ++ K + E L +N L L L+N+ L ++ +
Sbjct: 1290 KL--KEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMES 1347
Query: 537 ---MTLELKNQQEDINNNKKQEERMLKQI 562
+E + + +N ++Q+E++ ++I
Sbjct: 1348 KDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
Score = 62.4 bits (150), Expect = 2e-09
Identities = 113/523 (21%), Positives = 227/523 (43%), Gaps = 56/523 (10%)
Query: 390 LLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYE 449
LL Q +K E +I ++ K++ + ++T+N+E + + +
Sbjct: 128 LLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFD--------LQWMEVT 179
Query: 450 NKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENE 509
+ E I LK L L+ R++ + I+L+ + ++ +
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETI-IELSEERDGLHFLPHASSSAQSPCGSP 238
Query: 510 KLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETE 569
+K TE H LS+E + + + EL+ + E + + K++ E+M +++ LQ+
Sbjct: 239 GMKRTESRQH---LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN 295
Query: 570 TQLRNE---LEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY---IEELQQENK 623
L ++ R+EL R++ ++DK E + ++++ + Y +EEL+++N+
Sbjct: 296 MNLLSDARSARMYRDELDALREKA-VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
Query: 624 ALKKKGTAESKQLNVYEIKVNKL-ELELESAKQKFGEITDTYQKEIEDKKIS---EENLL 679
L + T QL + +KL ELE E+ + K +++++ KKI EEN+
Sbjct: 355 VLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMT 414
Query: 680 EEVEKAKVIADEAVKLQKEID-------------KRCQHKIAEMVA----LMEKHKHQYD 722
E+ + K DE++ L E++ K H++ E+ + +E
Sbjct: 415 LEMAQ-KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473
Query: 723 KIIEERDS-----ELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLE-IEREEKEK 776
K +EE + E K + E+ + R S ++E+ L+ E++ K+ L+ + K+
Sbjct: 474 KTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI--LENEIVQEKQSLQNCQNLSKDL 531
Query: 777 LKREA--KENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKD 834
+K +A ++ TL+E +++ + E + + S SQ +S D I K+
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQ-ISAEARVKD--IEKE 588
Query: 835 KRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEE 877
+ L S K T S+ L K K K +L+ + EE
Sbjct: 589 NK-ILHESIKET-SSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 143 bits (360), Expect = 9e-34
Identities = 185/805 (22%), Positives = 360/805 (44%), Gaps = 135/805 (16%)
Query: 88 QEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKA 147
+E LK+ + NS L K ++ ++ + + ST A+LR+ ++ L++ + I + +
Sbjct: 466 EEQLKEK-VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQK 524
Query: 148 IQEL----QFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEK----TKK 199
IQ L Q E +SL LE+ ++ I+ + N L+E E+ T+K
Sbjct: 525 IQNLEALLQKSKENISL-LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEK 583
Query: 200 YEYEREETRQVYMDLNNNIEKM---ITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQE 256
+ + E +Q +L++ +++ + A ++ + E S E++ +L E EK+ L+ +
Sbjct: 584 LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQ 643
Query: 257 YKKE----------------------------INDKEKQVSLLLIQITEKENKMKD---- 284
K + + DK+++++ + Q+ + K++D
Sbjct: 644 IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEH 703
Query: 285 ---LTFLLEESRDKVNQLEEKT--------KLQSENLK---------QSIEKQHHLTKEL 324
L L+E ++K LE+KT KL++++L+ Q +++Q L +L
Sbjct: 704 CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL 763
Query: 325 EDIKVSLQRSVSTQKALEE----DLQIATKTICQLTEEKETQMEE-----------SNKA 369
E L + + +K + DLQ ++ + + ++ Q EE S +
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET 823
Query: 370 RAAHSFVVTEFETTVCSLEEL----------LRTEQQRLEKNEDQLKILTMELQKKSS-- 417
+ H + +TTV L+++ L T + +L K D LK E +K++
Sbjct: 824 KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKG 883
Query: 418 -----ELEEMTK-LTNNKEVELEELKKVLGE-KETLLYENKQFEKIAEELKGTEQELI-- 468
+LE+ K L + +V++E K E K++L E + ++ EL +++LI
Sbjct: 884 KAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA 943
Query: 469 -GLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLEN 527
L+ EKE L+ + + S + K+++ L+ EL+ L+ TEL NKL
Sbjct: 944 QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE---NKLQ--- 997
Query: 528 KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
++LTQ ++ E K + + NN ++ + KQ LQ +EL R++LK
Sbjct: 998 QQLTQAAQELAAE-KEKISVLQNNYEKSQETFKQ---LQSDFYGRESELLATRQDLKS-- 1051
Query: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLE 647
V+ KL ++E+ + R Q+ N+NK I+EL+ L++ + +QL
Sbjct: 1052 --VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ---------- 1099
Query: 648 LELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIAD-EAVKLQKEIDKRCQHK 706
E A Q + +KE+ ++E++ L E+E+ K + E KL +E+
Sbjct: 1100 -ERCKALQDIQKEKSLKEKEL----VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1154
Query: 707 IAEMVALMEKHKHQYDKIIE---ERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSV 763
I E+ L + + + +E + DS + +++ Q L+ ++ E LK E +
Sbjct: 1155 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEK 1214
Query: 764 KKQLEIEREEKEKLKREAKENTATL 788
+ +L E +EKE ++ +EN A L
Sbjct: 1215 EAKLHSEIKEKEVGMKKHEENEAKL 1239
Score = 131 bits (329), Expect = 4e-30
Identities = 177/818 (21%), Positives = 361/818 (44%), Gaps = 123/818 (15%)
Query: 60 ENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSE-GLSRVYSKLYKEAEKIKK 118
E ++ ++ K N L Q + DC + S L SE L R++ +L ++ E +K
Sbjct: 322 EEKHNEESVSKKNIQATLHQK-DLDCQQLQ----SRLSASETSLHRIHVELSEKGEATQK 376
Query: 119 WKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQE-NKDLIKENN 177
K EL + E+K Q ++A+ K +Q+ + E+ L+L+ I + + L++
Sbjct: 377 LK----EELSEVETKYQH----LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428
Query: 178 ATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRL 237
LKE S+EK E + + + L +++ +T EL+ Q +
Sbjct: 429 QLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLD---- 484
Query: 238 EMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVN 297
K K+ +++ Q L+Q ++ + + + +L QI +K+ K+++L LL++S++ ++
Sbjct: 485 ----KTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
Query: 298 QLEEK-----TKLQSEN-----LKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQI 347
LE++ K+Q+ L Q EK H L +++ + L+ + K +E+L
Sbjct: 541 LLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH- 599
Query: 348 ATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLK- 406
+ E+ RAA V++ ET+V L L ++++ + + Q+K
Sbjct: 600 ------------DQVQEQKAHLRAAQDRVLS-LETSVNELNSQLNESKEKVSQLDIQIKA 646
Query: 407 ----ILTMELQKKS------SELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQF-EK 455
+L+ E K + + L+ +K+ EL ++ L + L + ++ +
Sbjct: 647 KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 706
Query: 456 IAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTE 515
+ LK +++ + L E++ +LE Q+ + + +L+ ++ NT+
Sbjct: 707 LESHLKEYKEKYLSL----EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 762
Query: 516 LTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNK------KQEERMLKQ-IENL-QE 567
L +LS + + + S L+L+ + E + + K ++E+++LKQ E L QE
Sbjct: 763 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQE 822
Query: 568 TETQ---LRNELEYVREELKQKRDE----------VKCKLDKSEENCNNLRKQVENKNK- 613
T+ Q L N ++ EL++ + E VK KL K ++ N + + E +N+
Sbjct: 823 TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882
Query: 614 ---------------------YIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELES 652
+E +E K LKK E + + ++++N ++ +L
Sbjct: 883 GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942
Query: 653 AKQKFGEITDTYQK---EIEDKKISEENLLEEVE----KAKVIADEAVKLQKEIDKRCQH 705
A+ + Q+ I + K S E +++E + K+ + +L+ ++ ++
Sbjct: 943 AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
Query: 706 KIAEMVALMEK---HKHQYDKIIEERDSELGLYKSKEQEQSSLR---ASLEIELSNLKAE 759
E+ A EK ++ Y+K E + +E E + R S+E +LS + +
Sbjct: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 760 LLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQ 797
L+S + Q+ + KL +E K ATL++ KK Q
Sbjct: 1063 LISNRNQI----GNQNKLIQELKTAKATLEQDSAKKEQ 1096
Score = 121 bits (304), Expect = 3e-27
Identities = 125/581 (21%), Positives = 275/581 (47%), Gaps = 63/581 (10%)
Query: 107 SKLYKEAEKIKKWKVSTEAEL----------RQKESKLQENRKIIEAQRKAI-QELQFGN 155
++L K+ E K+ ST +L +QK +K +E ++I++ + + QE + +
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 156 EKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK----KYEYEREETRQVY 211
E+++ +++ + E + + E A + +K+ ++ ++ K ++E E ++ +
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 212 MDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLL 271
+DL +++ +L+VQ EN+ E +LK+ EK + + K E+N ++Q L+
Sbjct: 888 LDLEKTCKELK---HQLQVQMENTLKEQK-ELKKSLEKEKEASHQLKLELNSMQEQ--LI 941
Query: 272 LIQITEKENKMKD------LTFLLEESRDKVNQLE-----------EKTKLQSENLKQSI 314
Q T K+N+ ++ + L + S K Q+E +KT+L+++ +Q
Sbjct: 942 QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT 1001
Query: 315 EKQHHLTKELEDIKV---SLQRSVSTQKALEEDLQ------IATKTICQLTEEKETQMEE 365
+ L E E I V + ++S T K L+ D +AT+ + EEK + +E
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 366 ---SNKARAAH-SFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSEL-E 420
SN+ + + + ++ E +T +LE+ ++Q+L++ L+ + E K EL
Sbjct: 1062 DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN 1121
Query: 421 EMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHD 480
E +KL +E++ + K++ E L + K LK +Q LI + +
Sbjct: 1122 EKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADS 1181
Query: 481 LEIQLTAITTSEQYYSKEVKDLKTELENEKL-KNTELTSHCNKLSLENKELTQETSDMTL 539
L+ + ++Q +VK + EL+ E + K +L S + + K+ + + +T+
Sbjct: 1182 LKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM 1241
Query: 540 ELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKC------- 592
++ E++ KK+ + +++ L++ LR E+ + ++ +DE +
Sbjct: 1242 QITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLK 1301
Query: 593 ---KLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGT 630
+++K + L+++++N ++EL +EN++L+ K T
Sbjct: 1302 GEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHT 1342
Score = 111 bits (278), Expect = 3e-24
Identities = 167/851 (19%), Positives = 368/851 (43%), Gaps = 82/851 (9%)
Query: 87 YQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRK 146
Y E LK +LE +GL + + K + AEL+ E +L+E + +
Sbjct: 105 YSEELK-KELEKYQGLQQ-------QEAKPDGLVTDSSAELQSLEQQLEE----AQTENF 152
Query: 147 AIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREE 206
I++++ E+ + +L I + K E + R +K + E +
Sbjct: 153 NIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAE----------QKVTRLTEELNK 202
Query: 207 TRQVYMDLNNN------IEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKE 260
V DL IE + +EL VQ + M + + + EK++ ++ + +
Sbjct: 203 EATVIQDLKTELLQRPGIEDVAVLKKEL-VQVQTLMDNMTLERERESEKLKDECKKLQSQ 261
Query: 261 INDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQS------- 313
E +S L ++ + ++ L++ + VN+L +K + +ENL +
Sbjct: 262 YASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKL 321
Query: 314 IEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAH 373
EK + + ++I+ +L + + L+ L + ++ ++ E + E + K +
Sbjct: 322 EEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL 381
Query: 374 SFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVEL 433
S V T+++ ++L +QQR EK + L+ L E+ + S+L E + L
Sbjct: 382 SEVETKYQHLKAEFKQL---QQQREEKEQHGLQ-LQSEINQLHSKLLETERQLGEAHGRL 437
Query: 434 EELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQ 493
+E +++ EK L+ + +Q + +L E++L +EK + E+Q T +Q
Sbjct: 438 KEQRQLSSEK--LMDKEQQVADLQLKLSRLEEQL------KEKVTNSTELQHQLDKTKQQ 489
Query: 494 YYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKK 553
+ ++ T K E + ++ + + Q+ ++ L+ +E+I+ +K
Sbjct: 490 HQEQQALQQST-----TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK 544
Query: 554 QEERMLKQIENLQETETQLRNELE----YVREELKQKRDEVKCKLDKSEENCNNLRKQVE 609
+ E + +I+ E ET + N+L+ ++E++ Q +++K + + ++ NL QV+
Sbjct: 545 EREDLYAKIQ-AGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603
Query: 610 NKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKF--GEITDTYQK- 666
+ ++ Q +L+ + QLN + KV++L++++++ + E T Q+
Sbjct: 604 EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 663
Query: 667 EIEDKKISEENLL----EEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYD 722
++++ + +N L +E+ K D+ ++ + C +++ + ++++K +Y
Sbjct: 664 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHC----SQLESHLKEYKEKYL 719
Query: 723 KIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAK 782
+ ++ + G K E + ++AS E L +L+ + + LE+ E K K
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ-RQLNTDLELRATELSKQLEMEK 778
Query: 783 ENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTS 842
E ++ + KK++ I KL + Q + ++F ++ +K + + L
Sbjct: 779 EIVSSTRLDLQKKSEAL----ESIKQKLTKQEEEKQILKQDFETLSQE-TKIQHEELNNR 833
Query: 843 AKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLS 902
+ T+ T L K K +L ++ + +S K K FE + + DL
Sbjct: 834 IQTTV-TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL-- 890
Query: 903 MVSEEETLKTL 913
E+T K L
Sbjct: 891 ----EKTCKEL 897
Score = 99.8 bits (247), Expect = 1e-20
Identities = 133/647 (20%), Positives = 275/647 (42%), Gaps = 109/647 (16%)
Query: 281 KMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKA 340
K D+T L +E +D L+E+ K SE LK+ +EK LQ+ +
Sbjct: 81 KRDDVTLLRQEVQDLQASLKEE-KWYSEELKKELEKYQ-----------GLQQQEAKPDG 128
Query: 341 LEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEK 400
L D +++ Q EE +T+ + + + T + ++ E+ E
Sbjct: 129 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 401 NEDQLKILTMELQKKSSELEEM-TKLTNNKEVE-LEELKKVLGEKETLLYENKQFEKIAE 458
E ++ LT EL K+++ ++++ T+L +E + LKK L + +TL+ +N E
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLM-DNMTLE---- 243
Query: 459 ELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKE--VKDLKTELENEKLKNTEL 516
RE+E L+ + + + QY S E + L++EL +
Sbjct: 244 ---------------RERESEKLKDECKKLQS--QYASSEATISQLRSELAKGPQEVAVY 286
Query: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNEL 576
KL ELTQ+ +T L +++D +++ +N+Q T Q +
Sbjct: 287 VQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC 346
Query: 577 EYVREELKQKR---DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAES 633
+ ++ L + +L + E L++++ + L+ E K L+++ +
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
Query: 634 KQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAV 693
+ + ++N+L +L +++ GE + + E +++S E L+ +K + +AD +
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGE---AHGRLKEQRQLSSEKLM---DKEQQVADLQL 460
Query: 694 KLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIEL 753
KL R + ++ E V + +HQ DK K + QEQ +L+ S +L
Sbjct: 461 KL-----SRLEEQLKEKVTNSTELQHQLDKT-----------KQQHQEQQALQQSTTAKL 504
Query: 754 SNLKAELLSVKKQLEIEREEK----EKLKREAKENTATLKEKKDKKTQTFLLETPEIYWK 809
+ +L V +Q+ ++++K E L +++KEN + L+++++ ++Y K
Sbjct: 505 REAQNDLEQVLRQIG-DKDQKIQNLEALLQKSKENISLLEKERE-----------DLYAK 552
Query: 810 LDS----KAVPSQTVSRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKL 865
+ + AV +Q +N T + ++ +K ++
Sbjct: 553 IQAGEGETAVLNQLQEKNHTLQEQVTQLTEK--------------------LKNQSESHK 592
Query: 866 QQRENLNIPIEESK------KKRKMAFEFDINSDSSETTDLLSMVSE 906
Q +ENL+ ++E K + R ++ E +N +S+ + VS+
Sbjct: 593 QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ 639
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 142 bits (359), Expect = 1e-33
Identities = 191/852 (22%), Positives = 375/852 (44%), Gaps = 101/852 (11%)
Query: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDL---IKENNATR 180
E E Q ++KL + + RK I+EL N + + ++ + E+ L +++ + T
Sbjct: 381 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTS 440
Query: 181 HLC-----NLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMI-TAFEELRVQAEN 234
L +L E ++ + K E E + + +L ++ + A + L+++ EN
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
Query: 235 SRLEMHFKL--------KEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLT 286
RL ++ K+ + Q+L ++ KE EK + L +EN + +
Sbjct: 501 QRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL------RENSERQIK 554
Query: 287 FLLEESR---DKVNQLEEKTKLQSENLKQSIEKQHHLTKE-LEDIKVSLQRSVSTQKALE 342
L +E+ V+ L +++++ +E + IEK++ + E +++ L + ++ ++
Sbjct: 555 ILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK 614
Query: 343 EDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL------LRTEQQ 396
++L+ K + EE E ++ K +T + T +E L L E +
Sbjct: 615 KELE-HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENR 673
Query: 397 RLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKI 456
+L+K D K LT +L+ E ++ + +E LK + L ENK+ E
Sbjct: 674 KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE 733
Query: 457 AEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTEL 516
E+LK + + LL+A K+ LE+ + Q K LEN K +L
Sbjct: 734 KEQLK----KGLELLKASFKKTERLEVSYQGLDIENQRLQKT-------LENSNKKIQQL 782
Query: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNEL 576
S L +EN+ L + E++ + K+ E++ K+ ++L++ +QL +
Sbjct: 783 ESELQDLEMENQTLQKNL-----------EELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 577 EYVREELKQKRDEVKCKLDKSEEN---CNNLRKQVENKNKYI----------EELQQENK 623
+ + +E K+ R + + K EEN NL K+ + +K I +EL++ENK
Sbjct: 832 KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENK 891
Query: 624 ALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQK---EIEDKKISEENLLE 680
L K+ T + K L L +L S K K ++ + +K E+E +++E LL
Sbjct: 892 ELVKRATIDIKTLVT-------LREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 681 EVEKA-----KVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLY 735
+ + K++ + K+ + + KIA + A +E+ + ++ +E + Y
Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY 1004
Query: 736 ---KSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLK-EK 791
K ++ E+ +++S I + K E S + E+ + + + E + N ATL+ EK
Sbjct: 1005 EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI--EVERNNATLQAEK 1062
Query: 792 KDKKTQTFLLETPEIYWKLDSKAVPSQTVS---RNFT----SVDHGISKDKRDYLWTSAK 844
+ KTQ LET + A+ QTVS +N T + + + TS
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1122
Query: 845 NTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSMV 904
N + L + +++ + +++RE+L + +S K E +SE S++
Sbjct: 1123 NQNAQLLIQQSSLENENESVIKEREDLK-SLYDSLIKDHEKLELLHERQASEYE---SLI 1178
Query: 905 SEEETLKTLYRN 916
S+ TLK+ ++N
Sbjct: 1179 SKHGTLKSAHKN 1190
Score = 136 bits (343), Expect = 8e-32
Identities = 225/999 (22%), Positives = 425/999 (42%), Gaps = 182/999 (18%)
Query: 126 ELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNL 185
EL ++K++ R+ +E + + + + + E++ ++L+ QEN +L+ + + R +
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE 245
L + A + K E E ++ D+ F + RV+ +LKE
Sbjct: 312 L-DALREKAVRVDKLESEVSRYKERLHDIE---------FYKARVE----------ELKE 351
Query: 246 DYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKEN-----KMKDLTFLLEESRDKVNQLE 300
D + + + + ++ + L EKEN K+ D+ + R K+ +L
Sbjct: 352 DNQVLLETKTMLEDQLEGTRARSDKL--HELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
Query: 301 EKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKA---------------LEEDL 345
E+ KQS+++ HL ELE I + + S + QK+ LE +
Sbjct: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
Query: 346 QIATKTICQL---------TEEKETQMEESN-----KARAAHSFVVTEFET--TVCSLEE 389
Q TKT+ +L K +ME+ N K + +V E ++ +L +
Sbjct: 470 QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSK 529
Query: 390 LLRTEQQRLEK--------NEDQLKILTME---LQKKSSELEEMTKLTNNKEV-ELEELK 437
L E+ +LEK +E Q+KIL E L + S L + ++++ V ++E+
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN 589
Query: 438 KVLGE--KET------LLYENKQFEKIAEELK---GTEQELIGLLQAREKEVHDLEIQLT 486
K+L E KET + +E +Q +K E K +EL L EKE L+ ++T
Sbjct: 590 KILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKIT 649
Query: 487 AI-TTSEQYYSKEVKDLKTELENEKLKNT-----ELTSHCNKLSLENKELTQETSDMTLE 540
+ T E+ + E ++ + E EN KLK T LT L EN +L +E LE
Sbjct: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE----NLE 705
Query: 541 LKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEEN 600
L+ E + + ++ + + L+ + QL+ LE ++ K K + ++ +
Sbjct: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK-KTERLEVSYQGLDIE 764
Query: 601 CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEI---KVNKLELELESAKQKF 657
L+K +EN NK I++L+ E + L+ + K L +I ++ +LE E +S +Q+
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824
Query: 658 GEITD------------TYQKEIEDKKISEENL----LEEVEK-----------AKVIAD 690
++ Q EI+D + E N+ LE+ K + V
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
Query: 691 EAVKLQKEIDKRCQHKIAEMVAL-----------------MEKHKHQYDKI--------I 725
E K KE+ KR I +V L +EK H+ +KI
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
Query: 726 EERDSELGLYKSKEQE-QSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKEN 784
+E+ ++ YK E + +S+L+ SLEI+ + A +++ ++ +++LK K+N
Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK-TVKKN 1003
Query: 785 TATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSV-DHGISKDKRDYLWTSA 843
LK+++D+ + + +P I + + SQ +R V D I ++ + +
Sbjct: 1004 YEALKQRQDE--ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE 1061
Query: 844 KNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESK---KKRKMAFEFDINSDSSETTDL 900
K L T L + T + ++ + + ++E + + + + ++ +S++T L
Sbjct: 1062 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1121
Query: 901 L------------------SMVSEEETLKTLYRNNNPPASHLCVKTPKKAP--SSLTTPG 940
+ S++ E E LK+LY + L + ++A SL +
Sbjct: 1122 MNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKH 1181
Query: 941 STLK-----FGAIRKMREDRWAVIAKMDRKKKLKEAEKL 974
TLK + EDR+ + K +K +L++ EK+
Sbjct: 1182 GTLKSAHKNLEVEHRDLEDRYNQLLK--QKGQLEDLEKM 1218
Score = 122 bits (307), Expect = 1e-27
Identities = 185/764 (24%), Positives = 334/764 (43%), Gaps = 124/764 (16%)
Query: 96 LENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKL--QENRKIIEAQRKAIQELQF 153
L+N + LS+ L KE +++K + T E +++ K+ QEN + + Q Q
Sbjct: 521 LQNCQNLSK---DLMKEKAQLEK-TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQI 576
Query: 154 GNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMD 213
E KD+ KEN +L E+ ++ K K E+E+ RQ+ +
Sbjct: 577 SAEA----------RVKDIEKENK-------ILHESIKETSSKLSKIEFEK---RQIKKE 616
Query: 214 LNNNIEKMITAFEELR-----VQAENSRLEMHF-KLKEDYEKIQHLEQEYKKEINDKEKQ 267
L + EK A EEL ++ EN L+ LK EKI+ LEQE E+ + ++
Sbjct: 617 LEHYKEKGERA-EELENELHHLEKENELLQKKITNLKITCEKIEALEQE-NSELERENRK 674
Query: 268 VSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT---KLQSENLKQSIEKQHHL---T 321
+ L + K+LTF LE + +QL+E+ + E+LK + K L
Sbjct: 675 LKKTL-------DSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 322 KELEDIKVSLQRSVSTQKAL---EEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
KELE K L++ + KA E L+++ + + + + +E SNK +
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKK-------IQ 780
Query: 379 EFETTVCSLEELLRTEQQRLEKNEDQLKILTM---ELQKKSSELEEMTKLTNNKEVELEE 435
+ E+ + LE E Q L+KN ++LKI + +L+K++ LE+ T + +LE+
Sbjct: 781 QLESELQDLE----MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK 836
Query: 436 LKKVLGE----KETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTS 491
K L + K+T L EN E+ T + IG+ + + +LE + +
Sbjct: 837 ENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKR 896
Query: 492 EQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLE------NKEL----TQETSDMTLEL 541
K + L+ +L +EKLK ++ + KL+ E NKE Q T D +L
Sbjct: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956
Query: 542 KNQQEDINNNKK---QEERMLKQIENLQET---ETQLRNELEYVR---EELKQKRDE--- 589
+ + K +EE++ L+E+ QLR EL+ V+ E LKQ++DE
Sbjct: 957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016
Query: 590 ------VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKV 643
+ + +K E +++ + E+++ N L+ + A QL E +
Sbjct: 1017 VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1076
Query: 644 NKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRC 703
N L+ ++ + ++ + + E+N + + AK+ + + +
Sbjct: 1077 NNLQAQILALQR-------------QTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN 1123
Query: 704 QHKIAEMVALMEKHKHQYDKIIEERDSELGLYKS--KEQEQSSL----RASLEIELSNLK 757
Q+ A+++ +++ + +I+ER+ LY S K+ E+ L +AS L +
Sbjct: 1124 QN--AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKH 1181
Query: 758 AELLSVKKQLEIEREEKE-------KLKREAKENTATLKEKKDK 794
L S K LE+E + E K K + ++ LK +++K
Sbjct: 1182 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1225
Score = 99.4 bits (246), Expect = 1e-20
Identities = 140/634 (22%), Positives = 275/634 (43%), Gaps = 96/634 (15%)
Query: 91 LKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQE 150
L+D ++EN + L + +L ++++++ + ++ L Q+ S+L++++K +E + K +++
Sbjct: 786 LQDLEMEN-QTLQKNLEELKISSKRLEQLEKENKS-LEQETSQLEKDKKQLEKENKRLRQ 843
Query: 151 LQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQV 210
E LEE + +L KEN + KE+C R E K+ +E ++
Sbjct: 844 QA---EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE---NKELVKRA 897
Query: 211 YMDLNNNI---EKMITAFEELRVQAENSRLEMHFKLKEDYEKI----------------- 250
+D+ + E +++ E+L+ Q N+ LE KL + EKI
Sbjct: 898 TIDIKTLVTLREDLVS--EKLKTQQMNNDLE---KLTHELEKIGLNKERLLHDEQSTDDS 952
Query: 251 ------QHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLT----------FLLEESRD 294
LE KK + KE++++ L ++ E N + L L++ +D
Sbjct: 953 RYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQD 1012
Query: 295 KVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIK---VSLQRSVSTQKALEEDLQIATKT 351
+ ++ + E+ K E Q T+EL +K + ++R+ +T +A ++ L+ K
Sbjct: 1013 EERMVQSSPPISGEDNKWERESQ-ETTRELLKVKDRLIEVERNNATLQAEKQALKTQLK- 1070
Query: 352 ICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTME 411
Q+E N A + ++ L+T+ +L+ L +
Sbjct: 1071 ----------QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTS 1120
Query: 412 LQKKSSE-LEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELI-- 468
L ++++ L + + L N E ++E + + ++L+ ++++ E + E + LI
Sbjct: 1121 LMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISK 1180
Query: 469 -GLLQAREK----EVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTE---LTSHC 520
G L++ K E DLE + + + K LK E E L+N + +
Sbjct: 1181 HGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY 1240
Query: 521 NKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVR 580
KL EN L S + E + Q D N K + N + +T+L E ++
Sbjct: 1241 KKLCGENDRLNHTYSQLLKETEVLQTDHKNLK-------SLLNNSKLEQTRLEAEFSKLK 1293
Query: 581 EELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY----IEELQQENKALKKKGTAESKQL 636
E+ Q+ D KL+ E + L+ +E +N++ I+ L +N+ L ++ ESK L
Sbjct: 1294 EQY-QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQ-NMESKDL 1351
Query: 637 -----NVYEIKVNKLELELESAKQKFGEITDTYQ 665
Y K+N+L + E ++K I D Y+
Sbjct: 1352 FHVEQRQYIDKLNELRRQKEKLEEK---IMDQYK 1382
Score = 80.1 bits (196), Expect = 9e-15
Identities = 109/494 (22%), Positives = 229/494 (46%), Gaps = 53/494 (10%)
Query: 325 EDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTV 384
EDI+ L+ K L ++ ++TI +L+EE++ + + +A S
Sbjct: 184 EDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQS---------P 234
Query: 385 CSLEELLRTEQQR-----LEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKV 439
C + RTE ++ L + +++ L EL++K+ +L + + E+EL+ L++
Sbjct: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ- 293
Query: 440 LGEKETLLYENKQFEKIAEELKGTEQELIGL------LQAREKEVHDLEIQLTAITTSEQ 493
E LL + + +EL ++ + + + ++ +HD+E + ++
Sbjct: 294 --ENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351
Query: 494 YYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKK 553
++ + + KT LE++ + ++L EN +L + DM +E + ++K
Sbjct: 352 -DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER-------DMDRK 403
Query: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQV-ENKN 612
+ E ++++ L+ + Q +E ++ EL+Q + + SE +L +V E +
Sbjct: 404 KIEELMEENMTLEMAQKQSMDESLHLGWELEQ----ISRTSELSEAPQKSLGHEVNELTS 459
Query: 613 KYIEELQQENKALKKKGTAESKQLNVYEIKVNKLE-LELESAKQKFGEITDTYQKEIEDK 671
+ +L+ EN++L K T E + V ++ N + L++E Q+ + + + EI +
Sbjct: 460 SRLLKLEMENQSLTK--TVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQE 517
Query: 672 KISE---ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEER 728
K S +NL +++ K K ++ ++ +E +R Q KI E +H +Q + +R
Sbjct: 518 KQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER-QIKILEQ---ENEHLNQTVSSLRQR 573
Query: 729 D--SELGLYKSKEQEQSSLRASLE---IELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
S K E+E L S++ +LS ++ E +KK+LE +E+ E + E E
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE--RAEELE 631
Query: 784 NTATLKEKKDKKTQ 797
N EK+++ Q
Sbjct: 632 NELHHLEKENELLQ 645
Score = 62.4 bits (150), Expect = 2e-09
Identities = 113/523 (21%), Positives = 227/523 (43%), Gaps = 56/523 (10%)
Query: 390 LLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYE 449
LL Q +K E +I ++ K++ + ++T+N+E + + +
Sbjct: 128 LLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFD--------LQWMEVT 179
Query: 450 NKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENE 509
+ E I LK L L+ R++ + I+L+ + ++ +
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETI-IELSEERDGLHFLPHASSSAQSPCGSP 238
Query: 510 KLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETE 569
+K TE H LS+E + + + EL+ + E + + K++ E+M +++ LQ+
Sbjct: 239 GMKRTESRQH---LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN 295
Query: 570 TQLRNE---LEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY---IEELQQENK 623
L ++ R+EL R++ ++DK E + ++++ + Y +EEL+++N+
Sbjct: 296 MNLLSDARSARMYRDELDALREKA-VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
Query: 624 ALKKKGTAESKQLNVYEIKVNKL-ELELESAKQKFGEITDTYQKEIEDKKIS---EENLL 679
L + T QL + +KL ELE E+ + K +++++ KKI EEN+
Sbjct: 355 VLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMT 414
Query: 680 EEVEKAKVIADEAVKLQKEID-------------KRCQHKIAEMVA----LMEKHKHQYD 722
E+ + K DE++ L E++ K H++ E+ + +E
Sbjct: 415 LEMAQ-KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLT 473
Query: 723 KIIEERDS-----ELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLE-IEREEKEK 776
K +EE + E K + E+ + R S ++E+ L+ E++ K+ L+ + K+
Sbjct: 474 KTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI--LENEIVQEKQSLQNCQNLSKDL 531
Query: 777 LKREA--KENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKD 834
+K +A ++ TL+E +++ + E + + S SQ +S D I K+
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQ-ISAEARVKD--IEKE 588
Query: 835 KRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEE 877
+ L S K T S+ L K K K +L+ + EE
Sbjct: 589 NK-ILHESIKET-SSKLSKIEFEKRQIKKELEHYKEKGERAEE 629
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 141 bits (355), Expect = 3e-33
Identities = 206/921 (22%), Positives = 401/921 (43%), Gaps = 157/921 (17%)
Query: 87 YQEGLKDS-DLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQR 145
+QE +K + + SE L K +E+ +++ ++ +A L + E+KL++ ++ E R
Sbjct: 507 FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYR 566
Query: 146 KAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYERE 205
I EL+ LE+ +QENK+ K+ HL AEK K + +E
Sbjct: 567 TRILELE-------SSLEKSLQENKNQSKD--LAVHL----------EAEKNK---HNKE 604
Query: 206 ETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE 265
T V EK T E L+ Q + EK+Q L+Q+Y+ E+
Sbjct: 605 ITVMV--------EKHKTELESLKHQQDALWT----------EKLQVLKQQYQTEMEKLR 646
Query: 266 KQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELE 325
++ EKE +KD + + + ++ EKT L+ ++KQ+ ELE
Sbjct: 647 EKCE------QEKETLLKDKEIIFQA---HIEEMNEKT-LEKLDVKQT---------ELE 687
Query: 326 DIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQM-EESNKARAAHSFVVTEFETTV 384
+ L + + LEE+L + ++ +E E +M E+ N + ++ E E ++
Sbjct: 688 SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSI 747
Query: 385 CSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKE 444
E+ L+ DQ+ L + L+++ L+E N E +++ + L +
Sbjct: 748 QRTEKALK----------DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQAS 797
Query: 445 TLLYENKQFEKIA-EELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLK 503
L + ++ E+ K E++L L ++++ DLE + +T + KD+
Sbjct: 798 AKLDVFQSYQSATHEQTKAYEEQLAQL----QQKLLDLETERILLTKQVAEVEAQKKDVC 853
Query: 504 TELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE 563
TEL+ K++ +L K +N E+ Q+ +T +++ ED N ++Q +++L + E
Sbjct: 854 TELDAHKIQVQDLMQQLEK---QNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKE 910
Query: 564 N--LQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQ- 620
N LQ E Q + E+E + ++L K D + ++ E N K++E + +E+Q+
Sbjct: 911 NMILQMREGQ-KKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQET 969
Query: 621 -------ENKALKKKGTAESKQLNVYEIKVNKLELELESA----------------KQKF 657
+ LKK+ + +L+ E + N LE+ A K++
Sbjct: 970 LKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQI 1029
Query: 658 GEITDTYQKEIEDK-KISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKI--------- 707
+T+ +++E+ D I E+ L ++ E+ + I + ++ +++ + KI
Sbjct: 1030 ESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089
Query: 708 --AEMVALME---KHKHQYDKIIEERDSELGLYKSKEQEQSSLRA---SLEIELSNLKAE 759
E+ L E K +++ E+ + S Q+++ L+A LE++L+ E
Sbjct: 1090 MNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKE 1149
Query: 760 LLSVKKQLEIEREEKEKLKREAKENTATLK-------------EKKDKKTQTFLLE---- 802
+++QL + E+ KR+ E T+ LK EK +K + LE
Sbjct: 1150 NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
Query: 803 TPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAKNT--LSTPLPKAYTVKTP 860
+ E+ +LD ++ + T+ IS K + + + + +T + +A +KT
Sbjct: 1210 SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTC 1269
Query: 861 TKPKL--------QQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSMVSEEETLKT 912
T +L +++ LNI +++ + E N S D+ S+V+E+E L+
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQ----LEEKENQIKSMKADIESLVTEKEALQK 1325
Query: 913 LYRNNNPPAS--HLCVKTPKK 931
N AS C+ KK
Sbjct: 1326 EGGNQQQAASEKESCITQLKK 1346
Score = 123 bits (309), Expect = 7e-28
Identities = 169/866 (19%), Positives = 371/866 (42%), Gaps = 72/866 (8%)
Query: 91 LKDSDLEN-SEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAI- 148
+K ++LE+ S LS V +K E++ K T+ ++ E+K+ E + + Q +I
Sbjct: 681 VKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740
Query: 149 QELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETR 208
+E + ++ L++ I + + L+KE + E ++++ +
Sbjct: 741 KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKL 800
Query: 209 QVYMDLNNNIEKMITAFEELRVQAENSRLEMHFK---LKEDYEKIQHLEQEYKKEINDKE 265
V+ + + A+EE Q + L++ + L + +++ +++ E++ +
Sbjct: 801 DVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHK 860
Query: 266 KQVSLLLIQI----TEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLT 321
QV L+ Q+ +E E K+K LT + E + N+ +E+TK + +EK++ +
Sbjct: 861 IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTK------QILVEKENMIL 914
Query: 322 KELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEE-SNKARAAHSFVVTEF 380
+ E K ++ A E+ + I + + +E +ME+ KA+ + +
Sbjct: 915 QMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKL 974
Query: 381 ETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSE--LEEMTKLTNNKEVELEELKK 438
L++ L L + E Q +E+ + +S + +++L N++ ++E L +
Sbjct: 975 LDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTE 1034
Query: 439 VLGEK--ETLLYENKQFEKIAEELKGTEQELIGL-LQAREKEVHDLEIQLTAITTSEQYY 495
V + + + K+ + AEEL QE+ + LQ +E+EV +L+ ++ ++
Sbjct: 1035 VHRRELNDVISIWEKKLNQQAEEL----QEIHEIQLQEKEQEVAELKQKILLFGCEKEEM 1090
Query: 496 SKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQE 555
+KE+ LK E + EL + S L Q+ + + L+ + D+N + K+
Sbjct: 1091 NKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN 1150
Query: 556 ERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYI 615
+ +Q+ EL+ + EE K+K E+ KL ++E +L+ E NK +
Sbjct: 1151 TFLQEQLV-----------ELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSL 1199
Query: 616 EELQQENKAL-------------KKKGTAESKQ---LNVYEIKVNKLELELESAKQKFGE 659
E+ E K L K + E+K +N+ K N + + + + +
Sbjct: 1200 EDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTK 1259
Query: 660 ITDTYQKE---IEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVAL--- 713
+ + + + + + L EE + +A +E + + + A++ +L
Sbjct: 1260 VKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTE 1319
Query: 714 ---MEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQL-EI 769
++K + E++S + K + E + ++ EL K E+ S+ KQL ++
Sbjct: 1320 KEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL 1379
Query: 770 EREEKEKLKREAKENT-ATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVD 828
+ + + KE ++L+++ D++ L + ++ +K+D+ + +
Sbjct: 1380 NVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWS 1439
Query: 829 HGIS--KDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAF 886
+ S K K +T +NT+ ++ +K ++ E +N+ EE ++ K
Sbjct: 1440 NKFSEWKKKAQSRFTQHQNTVK---ELQIQLELKSKEAYEKDEQINLLKEELDQQNK--- 1493
Query: 887 EFDINSDSSETTDLLSMVSEEETLKT 912
FD E D M +E L+T
Sbjct: 1494 RFDCLKGEME-DDKSKMEKKESNLET 1518
Score = 115 bits (287), Expect = 3e-25
Identities = 166/749 (22%), Positives = 328/749 (43%), Gaps = 141/749 (18%)
Query: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQE-----------NKDL 172
+ ++++E+ L+ ++ I++ ++ L E + +L+E +QE L
Sbjct: 285 QQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKL 344
Query: 173 IKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYM-DLNNNIEKMITAFEELRVQ 231
I + ++L L++ +TK+ +E E ++ + L + I++M T EELR Q
Sbjct: 345 ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQ 404
Query: 232 AENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKM---KDLTFL 288
E S +L++ Q E+ +K + ++Q+ I+ T +E ++ ++L+ +
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKT--IEKTSEEERISLQQELSRV 462
Query: 289 LEESRD--KVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQ 346
+E D K + E+ KLQ + K+ K+ LTK+L+ R Q+ ++ L+
Sbjct: 463 KQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQT------REREFQEQMKVALE 516
Query: 347 IATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLK 406
+ ++++EKE Q E LE+ E Q K
Sbjct: 517 KSQSEYLKISQEKEQQ-------------------------------ESLALEELELQKK 545
Query: 407 ILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEK-----IAEELK 461
+ E + K +L++ + + +ELE E L ENK K + E
Sbjct: 546 AILTESENKLRDLQQEAETYRTRILELES------SLEKSLQENKNQSKDLAVHLEAEKN 599
Query: 462 GTEQELIGLLQAREKEVHDLEIQLTAITTSE-----QYYSKEVKDLKTELENEK---LKN 513
+E+ +++ + E+ L+ Q A+ T + Q Y E++ L+ + E EK LK+
Sbjct: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKD 659
Query: 514 TELTSHCNKLSLENKELTQETSDMTLE-LKNQQEDINNNKKQEERMLKQIENLQETETQL 572
E+ + +E ++ TLE L +Q ++ + + +LK L+E + L
Sbjct: 660 KEIIFQAH---------IEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVL 710
Query: 573 RNELEYVREELKQKRDE--------VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKA 624
+++ + +++EL+ K DE V + + E + K ++++ +E L +E
Sbjct: 711 KDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK 770
Query: 625 LKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEI-EDKKISEENLLEEVE 683
K+ A + L E + + E EL+ A K ++ +YQ E K EE L + +
Sbjct: 771 HLKEHQAHVENL---EADIKRSEGELQQASAKL-DVFQSYQSATHEQTKAYEEQLAQLQQ 826
Query: 684 KAKVIADEAVKLQKEI-DKRCQHKIAEMVALMEKHKHQYDKI---IEERDSEL------- 732
K + E + L K++ + Q K ++ ++ HK Q + +E+++SE+
Sbjct: 827 KLLDLETERILLTKQVAEVEAQKK--DVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 733 -GLYKS------KEQEQS----------------SLRASLEIELSNLKAE-----LLSVK 764
+Y+S KEQEQ+ + +EI L A+ +L+ +
Sbjct: 885 TQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944
Query: 765 KQLEIEREEK--EKLKREAKENTATLKEK 791
+ + + +EK EK+K++AKE TLK+K
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQETLKKK 973
Score = 109 bits (273), Expect = 1e-23
Identities = 173/750 (23%), Positives = 326/750 (43%), Gaps = 129/750 (17%)
Query: 89 EGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAI 148
E +K E E L + KL + K+KK +T EL QKE Q N K++E +
Sbjct: 957 EKVKQKAKEMQETLKK---KLLDQEAKLKKELENTALELSQKEK--QFNAKMLEMAQANS 1011
Query: 149 QELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKK-YEYEREET 207
+ ++ +E I+ ++ + + ++ ++ + AE+ ++ +E + +E
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRE--LNDVISIWEKKLNQQAEELQEIHEIQLQEK 1069
Query: 208 RQVYMDLNNNI----------EKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQE- 256
Q +L I K IT +E V+ + + E+ +LK+ + L Q+
Sbjct: 1070 EQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDE 1129
Query: 257 --YKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSI 314
K + E ++ L + T + ++ +L L EE + KV++L K K E QS+
Sbjct: 1130 TKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF-QSL 1188
Query: 315 EKQHHLT-KELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEK-ETQMEE-----SN 367
+ H + K LED + K L E+L I C+ TE E + E S+
Sbjct: 1189 KSSHEKSNKSLEDKSLEF-------KKLSEELAIQLDICCKKTEALLEAKTNELINISSS 1241
Query: 368 KARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTN 427
K A S + + + ++E L + + + E QL+ LT E + ++ T
Sbjct: 1242 KTNAILSRI-SHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE 1300
Query: 428 NKEVELEELK----KVLGEKETLLYENKQFEKIAEE-------LKGTEQELIGLLQAREK 476
KE +++ +K ++ EKE L E ++ A E LK E I + ++
Sbjct: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360
Query: 477 EVHDLEIQLTAITTSEQYYSKEVKDLKTELENE---KLKNTELTSHCNKLSLENKELTQE 533
E+ + +++++++ SK++ DL +L+N K ++S + E EL +
Sbjct: 1361 ELKEKKVEISSL-------SKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQ 1413
Query: 534 TSDMTLELKN---------QQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELK 584
D++ ++ +Q D +NK E + + Q TQ +N ++ ++ +L+
Sbjct: 1414 VQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK-----KKAQSRFTQHQNTVKELQIQLE 1468
Query: 585 QKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVN 644
K E K +E N L+++++ +NK + L+ E + K K E K +
Sbjct: 1469 LKSKEAYEK----DEQINLLKEELDQQNKRFDCLKGEMEDDKSK----------MEKKES 1514
Query: 645 KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQ 704
LE EL+S + E+ D I K I E+L E ++ QK+I+
Sbjct: 1515 NLETELKSQTARIMELED----HITQKTIEIESLNEVLKN--------YNQQKDIE---- 1558
Query: 705 HKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVK 764
HK L++K +H + ++ EE+D+ + KE E+ L +LE ++ ++KAEL
Sbjct: 1559 HK-----ELVQKLQH-FQELGEEKDNRV-----KEAEEKIL--TLENQVYSMKAEL---- 1601
Query: 765 KQLEIEREEKEKLKREAKENTATLKEKKDK 794
E K+E + ++K K+++
Sbjct: 1602 ----------ETKKKELEHVNLSVKSKEEE 1621
Score = 105 bits (262), Expect = 2e-22
Identities = 143/721 (19%), Positives = 319/721 (44%), Gaps = 61/721 (8%)
Query: 113 AEKIKKWKVSTEAELRQ--KESKLQENRK---IIEAQRKAIQELQFGNEKVSLKLEEGIQ 167
A+K++ S E+ R KES + + K + + R+++ L + S +
Sbjct: 62 AQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMD 121
Query: 168 -ENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFE 226
E +DL+ +++ L + R Y + E Y L +K+
Sbjct: 122 SEAEDLVGNSDSLNK--EQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILS 179
Query: 227 ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLT 286
+ + ++ E+ +L+ D + +HL++E+ + +K++ +S+L Q++ + ++++
Sbjct: 180 QSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGP 239
Query: 287 FLLEESRDKVNQLEEKTKL-----QSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKAL 341
++ + + QLE + ++ E+ + + + K LE ++ ++R + K
Sbjct: 240 MNVDVLKP-LPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRC 298
Query: 342 EEDLQIATKTICQLTEEKET-------QMEESNKARAAHSFVVTEFETTVCSLEELL-RT 393
+E +Q + LT EKE +++E K + H T+ T + + L+ +
Sbjct: 299 KETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQL 358
Query: 394 EQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQF 453
EQ + + + + L+ K E+ ++ + EEL++ + E +E +
Sbjct: 359 EQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFE--EL 416
Query: 454 EKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAI--TTSEQYYS--KEVKDLKTELENE 509
EK + TE+ AR K +++ Q+ I T+ E+ S +E+ +K E+ +
Sbjct: 417 EKALSTAQKTEE-------ARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDV 469
Query: 510 KLKNTELTSHCNKLS-LENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQET 568
K++E KL L KEL ++ ++T +L+ ++ + +E+M +E Q
Sbjct: 470 MKKSSE--EQIAKLQKLHEKELARKEQELTKKLQTREREF------QEQMKVALEKSQSE 521
Query: 569 ETQLRNELEYVRE-ELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK 627
++ E E L++ + K L +SE +L+++ E I EL+ + +
Sbjct: 522 YLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQ 581
Query: 628 KGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKV 687
+ +SK L V+ LE E ++ + + ++ E+E K ++ L EK +V
Sbjct: 582 ENKNQSKDLAVH------LEAEKNKHNKEITVMVEKHKTELESLKHQQDALW--TEKLQV 633
Query: 688 IADEAVKLQKEIDKRCQHK----IAEMVALMEKH-KHQYDKIIEERD---SELGLYKSKE 739
+ + +++ ++C+ + + + + + H + +K +E+ D +EL S+
Sbjct: 634 LKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSEL 693
Query: 740 QEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTF 799
E R LE ELS LK + +K++LE + +E++ ++ ++ E ++T+
Sbjct: 694 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKA 753
Query: 800 L 800
L
Sbjct: 754 L 754
Score = 96.3 bits (238), Expect = 1e-19
Identities = 148/722 (20%), Positives = 287/722 (39%), Gaps = 169/722 (23%)
Query: 113 AEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENK-- 170
+ K +WK ++ Q ++ ++E + +E + K E +E+++L EE Q+NK
Sbjct: 1439 SNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEK---DEQINLLKEELDQQNKRF 1495
Query: 171 DLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRV 230
D +K +++ ++ +K E E + M+L ++I + E L
Sbjct: 1496 DCLKGE---------MEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE 1546
Query: 231 QAENSRLEMHFKLKEDYEKIQHLEQ------------------------EYKKEINDKEK 266
+N + + KE +K+QH ++ K E+ K+K
Sbjct: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
Query: 267 QVSLLLIQITEKENKMKDLTFLLE-ESRDKVNQLEEKTK-----LQSENLKQSIEKQHHL 320
++ + + + KE ++K L LE ES K+ +L+ K + ++ + L Q EK+
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQY 1666
Query: 321 TK----ELEDIKVSLQRSVSTQKALEEDLQI-------------ATKTICQLTEEKETQM 363
K L ++ LQ LEE L+ + K + TE++E
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726
Query: 364 E-------------------ESNK-----ARAAHSFVVTEFETTVCSLEELLRTEQQRLE 399
+ E K + V + FE E L++ E +
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786
Query: 400 KNEDQLKI--LTMELQKKSSE---------------------------LEEMTKLTNNKE 430
++EDQ I L EL++K+ + +++ K KE
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846
Query: 431 VELEELKKVLGEKETLLYENKQFEKIA--------EELKGTEQ--------ELIG----- 469
+ + L++ + E ++ L K+ ++ E+L+ +Q EL+
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEE 1906
Query: 470 ----------LLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSH 519
LL E + +DLE +L +Q KE+ L+ +L + H
Sbjct: 1907 KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR------KEH 1960
Query: 520 CNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQL---RNEL 576
+L + KE QE + ++K +QED+ + + LKQ+ ++E TQL EL
Sbjct: 1961 QQELEILKKEYDQEREE---KIKQEQEDL---ELKHNSTLKQL--MREFNTQLAQKEQEL 2012
Query: 577 EYVREELKQKRDEVKCK-LDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQ 635
E +E K EV+ + L+ +E N L K++ K+ ++L++ K ++ A ++
Sbjct: 2013 EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKD---DDLKRTAKRYEEILDAREEE 2069
Query: 636 LNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKL 695
+ KV L+ +LE ++K+ + + + D E + +K +I+D +K
Sbjct: 2070 MTA---KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE 2126
Query: 696 QK 697
Q+
Sbjct: 2127 QE 2128
Score = 68.9 bits (167), Expect = 2e-11
Identities = 145/664 (21%), Positives = 283/664 (42%), Gaps = 97/664 (14%)
Query: 308 ENLKQSI-EKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEES 366
+ LKQ I E+Q L + L + S S T+ + T+ + + T +E+ +S
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTR--MRSRTSSFTEQLDEGTPNRESGDTQS 60
Query: 367 --NKARAAHSFVVTEFETTV-------CSLEELLRTEQQRLEKNEDQLKILTMELQKKS- 416
K + V + F + + S E L+RT R N L T S
Sbjct: 61 FAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSS-RESLNRLDLDSSTASFDPPSD 119
Query: 417 --SELEEMTKLTN--NKEVELEELKKVLGEKETLLYENKQFEKIA--EELKGTEQELIGL 470
SE E++ ++ NKE ++ L+++ E+ Y K E + + L+ +++L G+
Sbjct: 120 MDSEAEDLVGNSDSLNKEQLIQRLRRM--ERSLSSYRGKYSELVTAYQMLQREKKKLQGI 177
Query: 471 L-QAREKEVHDL-----EIQL-------------TAITTSEQYYS---KEVKDLKTELEN 508
L Q+++K + + E+Q+ ++ +QY S +V LK L N
Sbjct: 178 LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237
Query: 509 EKLKNTELTSHCNKLSLENKELTQE--------------TSDMTLELKNQQEDINNNKKQ 554
+ N ++ +L + + T+E TS TLE Q+ K+
Sbjct: 238 GPM-NVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV------KR 290
Query: 555 EERMLKQ----IENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVEN 610
+E +LK+ I++ +E T L +E E ++E+L ++ E++ D L Q+ +
Sbjct: 291 QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350
Query: 611 KNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIED 670
IE+L+Q+ K AE+K+ ++E K E E+ + + ++T ++ E
Sbjct: 351 AKNLIEQLEQD----KGMVIAETKR-QMHETLEMKEE-EIAQLRSRIKQMTTQGEELREQ 404
Query: 671 KKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDS 730
K+ SE EE+EKA A + + ++++ +I + E+ + + +
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQ 464
Query: 731 EL--GLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATL 788
E+ + KS E++ + L+ E EL+ + EL KK ERE +E++K +++ +
Sbjct: 465 EVVDVMKKSSEEQIAKLQKLHEKELARKEQEL--TKKLQTREREFQEQMKVALEKSQSEY 522
Query: 789 KEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAKNTLS 848
+ +K Q L E+ +L KA+ ++ S++K L A+ +
Sbjct: 523 LKISQEKEQQESLALEEL--ELQKKAILTE-------------SENKLRDLQQEAETYRT 567
Query: 849 TPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSMVSEEE 908
L +++ + Q ++L + +E K K + T+L S+ +++
Sbjct: 568 RILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMV---EKHKTELESLKHQQD 624
Query: 909 TLKT 912
L T
Sbjct: 625 ALWT 628
Score = 64.7 bits (156), Expect = 4e-10
Identities = 95/393 (24%), Positives = 173/393 (44%), Gaps = 62/393 (15%)
Query: 126 ELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNL 185
+L E+K E++ +I + +EL+ N+K SL + + +++ +NN
Sbjct: 1779 KLEHAEAKQHEDQSMIGHLQ---EELEEKNKKYSLIVAQHVEKEGG---KNNIQA----- 1827
Query: 186 LKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRV-QAENSRLEMHFKLK 244
K+ + +K E+E T Q+ +E+ I + V Q E R+EM +L
Sbjct: 1828 -KQNLENVFDDVQKTLQEKELTCQI-------LEQKIKELDSCLVRQKEVHRVEME-ELT 1878
Query: 245 EDYEKIQHLEQEYKK-------EINDKEKQVSLLLIQ--ITEKENKMKDLTFLL---EES 292
YEK+Q L+Q + E N +EK S L+ ++ E + DL F L E
Sbjct: 1879 SKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAERE 1938
Query: 293 RDKVNQ-----------LEEKTKLQSENLKQSI--EKQHHLTKELEDIKVS-------LQ 332
+ K+ + L ++ + + E LK+ E++ + +E ED+++ L
Sbjct: 1939 KQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLM 1998
Query: 333 RSVSTQKAL-EEDLQIATKTICQLTEEKETQM-----EESNKARAAHSFVVTEFETTVCS 386
R +TQ A E++L++ K +E E ++ EE+N+ + + + T
Sbjct: 1999 REFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKR 2058
Query: 387 LEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETL 446
EE+L ++ + L+ ELQKK + E + N V + EL+ L +K TL
Sbjct: 2059 YEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTL 2118
Query: 447 LYENKQFEKIAEELKGTEQELIGLLQAREKEVH 479
+ ++K E +E + L L+ EK V+
Sbjct: 2119 ISDSKLKE---QEFREQIHNLEDRLKKYEKNVY 2148
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 139 bits (349), Expect = 2e-32
Identities = 166/789 (21%), Positives = 349/789 (44%), Gaps = 80/789 (10%)
Query: 47 EFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVY 106
E A N E + S +K+ L Q C E L+ + L +
Sbjct: 859 EKQLAAENRLTEMETLQSQLMAEKLQLQEQL-QAETELCAEAEELRARLTAKKQELEEIC 917
Query: 107 SKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGI 166
L E+ ++ +AE ++ + +QE + +E + A Q+LQ KL++ +
Sbjct: 918 HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKK-L 976
Query: 167 QENKDLIKENNATRHLCNLLKETCA---RSAEKTKKYEYEREETRQVYMDLNNNIEKMIT 223
+E + ++++ N C L KE R AE T E E+++ + L N E MIT
Sbjct: 977 EEEQIILEDQN-----CKLAKEKKLLEDRIAEFTTNLTEEEEKSKSL-AKLKNKHEAMIT 1030
Query: 224 AFEELRVQAENSRLEMH----------FKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLI 273
EE + E R E+ L + ++Q E K ++ KE+++ L
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090
Query: 274 QITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQR 333
++ E+ + + E ++++L+E + + + ++ +++ L +ELE +K L+
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150
Query: 334 SVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRT 393
++ + A +E + +K ++ K+T EE+ +T ++E+ +
Sbjct: 1151 TLDSTAAQQE---LRSKREQEVNILKKTLEEEA--------------KTHEAQIQEMRQK 1193
Query: 394 EQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVEL-EELKKVLGEKETLLYENKQ 452
Q +E+ +QL+ + ++ + LE+ + N+ EL E+K +L K ++ K+
Sbjct: 1194 HSQAVEELAEQLE----QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKK 1249
Query: 453 FEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAIT----TSEQYYSKEVKDLKTELEN 508
E +EL+ E + +V L+++L +T S+ SK KD + LE+
Sbjct: 1250 VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDF-SALES 1308
Query: 509 EKLKNTELTSHCNK----LSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIEN 564
+ EL N+ LS + K++ E + +L+ ++E +N +KQ + Q+ +
Sbjct: 1309 QLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD 1368
Query: 565 LQ----------ETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY 614
++ ET +++ +L+ E L Q+ +E DK E+ L++++++
Sbjct: 1369 MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD 1428
Query: 615 IEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
++ +Q L+KK + K ++L E ++ K+ E D + E +K+
Sbjct: 1429 LDHQRQSACNLEKK-----------QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK 1477
Query: 675 EENLLEEVEKAKVIADEAVKLQKEIDKRCQ------HKIAEMVALMEKHKHQYDKIIEER 728
+L +E+A E +L K+ + + + V +EK K ++ +EE
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537
Query: 729 DSELGLYKSKEQEQSSLRASLEIELSNLKAEL-LSVKKQLEIEREEKEKLKREAKENTAT 787
++L + + Q + LE+ L +KA+ ++ + E E+K++L R+ +E A
Sbjct: 1538 KTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAE 1597
Query: 788 LKEKKDKKT 796
L++++ +++
Sbjct: 1598 LEDERKQRS 1606
Score = 124 bits (310), Expect = 6e-28
Identities = 138/613 (22%), Positives = 275/613 (44%), Gaps = 95/613 (15%)
Query: 247 YEKIQHLEQEYKKEINDKEKQVSLLLIQITEK----ENKMKDLTFLLEESRDKVNQLEEK 302
+ K++ L Q ++E K+ L +++ EK EN++ ++ L + + QL+E+
Sbjct: 831 FTKVKPLLQVSRQEEEMMAKEEEL--VKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQ 888
Query: 303 TKLQSENLKQSIEKQHHLT---KELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEK 359
+ ++E ++ E + LT +ELE+I L+ V ++ + LQ K + Q +E
Sbjct: 889 LQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQEL 948
Query: 360 ETQMEESNKARAAHSFVVTEFETTVCSLEE---LLRTEQQRLEKN----EDQLKILTMEL 412
E Q+EE AR E + LEE +L + +L K ED++ T L
Sbjct: 949 EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNL 1008
Query: 413 QKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQ 472
++ + + + KL N E + +L++ L +E + ++ EK +L+G +L +
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAMITDLEERLRREEK---QRQELEKTRRKLEGDSTDLSDQIA 1065
Query: 473 AREKEVHDLEIQL--------TAITTSEQYYSK-------------EVKDLKTELENEKL 511
+ ++ +L++QL A+ E+ ++ ++ +L+ +LE+E+
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA 1125
Query: 512 KNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQI--------- 562
+ L E + L E D TL+ Q+++ + ++QE +LK+
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELED-TLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Query: 563 ENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQEN 622
+QE + +E + E+L+Q + VK L+K+++ N R ++ N+ K +
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTK-RVKANLEKAKQTLENERGELANEVKVL------- 1236
Query: 623 KALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEV 682
L+ KG +E K+ K+E +L+ + KF E + + E+ DK V
Sbjct: 1237 --LQGKGDSEHKR--------KKVEAQLQELQVKFNE-GERVRTELADK----------V 1275
Query: 683 EKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGL---YKSKE 739
K +V D L + D + + AL + + + + EE +L L K E
Sbjct: 1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVE 1335
Query: 740 QEQSSLRASLEIE----------LSNLKAELLSVKKQLEIE---REEKEKLKREAKENTA 786
E++S R LE E ++ L A++ +KK++E E E++KR+ +++
Sbjct: 1336 DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395
Query: 787 TLKEKKDKKTQTF 799
L ++ ++K +
Sbjct: 1396 GLSQRHEEKVAAY 1408
Score = 111 bits (278), Expect = 3e-24
Identities = 201/923 (21%), Positives = 381/923 (41%), Gaps = 148/923 (16%)
Query: 91 LKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQE 150
L D E ++ + +L K+ E+++ E E QK L++ R++ E+Q I E
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL-ESQ---ISE 1115
Query: 151 LQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYE------- 203
LQ E + ++ +DL +E A + ++ A E K E E
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT 1175
Query: 204 -REETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN 262
EE + + +K A EEL Q E ++ ++K + EK + Q + E
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK-----RVKANLEKAK---QTLENERG 1227
Query: 263 DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE--------EKTKLQSEN----- 309
+ +V +LL + E+K K + L+E + K N+ E + TKLQ E
Sbjct: 1228 ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG 1287
Query: 310 -LKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEED----LQIATKTICQLTEEKET--- 361
L QS K LTK+ ++ LQ TQ+ L+E+ L ++TK + Q+ +EK +
Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQ---DTQELLQEENRQKLSLSTK-LKQVEDEKNSFRE 1343
Query: 362 QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEE 421
Q+EE +A+ E + +L + ++++E + L+ +K +LE
Sbjct: 1344 QLEEEEEAKH-------NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 422 MTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDL 481
+++ K ++L+K +T L + + + + +L Q L EK+
Sbjct: 1397 LSQRHEEKVAAYDKLEKT----KTRLQQ--ELDDLLVDLDHQRQSACNL----EKKQKKF 1446
Query: 482 EIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
+ L T Y++E + E ++ K L + + EL + + +
Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELER----LNKQF 1502
Query: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLD------ 595
+ + ED+ ++K + + K + L++++ L ++E ++ +L++ DE++ D
Sbjct: 1503 RTEMEDLMSSK---DDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559
Query: 596 -------------------KSEENCNNLRKQVENKNKYIEELQQENK---ALKKKGTAES 633
+SEE L +QV +E+ +++ A +KK +
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL 1619
Query: 634 KQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLL----EEVEKAKVIA 689
K L + NK E +K +E++D + S E +L E +K K +
Sbjct: 1620 KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSME 1679
Query: 690 DEAVKLQKEI------DKRCQHKIAEMV----------ALMEKHKHQYDKIIEERDSELG 733
E ++LQ+E+ ++ Q + E+ AL + K + + I + + EL
Sbjct: 1680 AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEEL- 1738
Query: 734 LYKSKEQEQSSL------RASLEIELSN--LKAELLSVKK----QLEIEREEKEKLKREA 781
+EQ + L +A+L+I+ N L E +K + ++ER+ KE LK +
Sbjct: 1739 ---EEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKE-LKVKL 1794
Query: 782 KENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWT 841
+E T+K K + ++ +LD++ Q + + K +D L
Sbjct: 1795 QEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE----KKLKDVLLQ 1850
Query: 842 SAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKK----KRKMAFEFDINSDSSET 897
+ K K T+ K Q + L EE+++ +RK+ E + D++ET
Sbjct: 1851 VDDERRNAEQYKDQADKASTRLK-QLKRQLEEAEEEAQRANASRRKLQRELE---DATET 1906
Query: 898 TDLLSMVSEEETLKTLYRNNNPP 920
D +M E +LK R + P
Sbjct: 1907 AD--AMNREVSSLKNKLRRGDLP 1927
Score = 107 bits (268), Expect = 4e-23
Identities = 133/595 (22%), Positives = 258/595 (43%), Gaps = 58/595 (9%)
Query: 69 QKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELR 128
QK++ L+QV + ++E L++ + E L + + L+ + +KK + L
Sbjct: 1323 QKLSLSTKLKQVEDEKNSFREQLEEEE-EAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381
Query: 129 QKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRH-LCNLLK 187
E ++ +K +E + +E +K+ QE DL+ + + R CNL K
Sbjct: 1382 TAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
Query: 188 ------ETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQ-AENSRLEMH 240
+ A + KY ER+ + + A EE Q AE RL
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501
Query: 241 FKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD-----K 295
F+ + E + + + K +++ EK L Q+ E + ++++L L+ + D +
Sbjct: 1502 FRT--EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559
Query: 296 VN----------QLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDL 345
VN L+ + + E KQ + + + ELED + +V+ +K LE DL
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL 1619
Query: 346 QIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQL 405
+ I + ++ +++ K +A + E + T S EE+L + ++NE +L
Sbjct: 1620 KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL----AQAKENEKKL 1675
Query: 406 KILTMELQKKSSELEEMTKLTNNKEVELEELKKVL----GEKETLLYENKQFEKIAEELK 461
K + E+ + EL + + E +EL + G+ L E ++ E +L+
Sbjct: 1676 KSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLE 1735
Query: 462 GTEQELIGLLQAREKEVHDLEIQLTAITTS---EQYYSKEVKDLKTELENEKLKNTELTS 518
+E G + + +Q+ I T E+ ++++ ++ + +LE + N EL
Sbjct: 1736 EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQ---NKEL-- 1790
Query: 519 HCNKLSLENKELT----QETSDMTLELKNQQ--EDINNNKKQEERMLKQIENLQETETQL 572
K+ L+ E T + S LE K Q E ++N K+ + KQ+ + TE +L
Sbjct: 1791 ---KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV---RRTEKKL 1844
Query: 573 RNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK 627
++ L V +E ++ ++ K + DK+ L++Q+E EE Q+ N + +K
Sbjct: 1845 KDVLLQVDDE-RRNAEQYKDQADKASTRLKQLKRQLEEAE---EEAQRANASRRK 1895
Score = 73.2 bits (178), Expect = 1e-12
Identities = 97/447 (21%), Positives = 197/447 (44%), Gaps = 71/447 (15%)
Query: 382 TTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLG 441
T V L ++ R E++ + K E+ +K+ +L + N+ E+E L+ L
Sbjct: 832 TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAE------------NRLTEMETLQSQLM 879
Query: 442 EKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKD 501
++ L E Q E EL +EL L A+++E+ ++ D
Sbjct: 880 AEKLQLQEQLQAET---ELCAEAEELRARLTAKKQELEEI-----------------CHD 919
Query: 502 LKTELENEKLKNTELTSHCNKLSLENKEL-----TQETSDMTLELKNQQEDINNNKKQEE 556
L+ +E E+ + L + K+ +EL +E++ L+L+ + K +EE
Sbjct: 920 LEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEE 979
Query: 557 RMLKQIEN--LQETETQLRNELEYVREELKQKRDEVK--CKL-DKSEENCNNLRKQVENK 611
+++ + +N L + + L + + L ++ ++ K KL +K E +L +++ +
Sbjct: 980 QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 612 NKYIEELQQENKALKKKGTAESKQL-----NVYEIKVN--KLELELESAKQKFGEITDTY 664
K +EL++ + L+ T S Q+ + E+K+ K E EL++A + E +
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE--EAA 1097
Query: 665 QKEIEDKKISE-----ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKH 719
QK + KKI E L E++E + ++A K ++++ + +E K
Sbjct: 1098 QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE-----------LEALKT 1146
Query: 720 QYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKR 779
+ + ++ ++ L +EQE + L+ +LE E +A++ ++++ EE
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEE----LA 1202
Query: 780 EAKENTATLKEKKDKKTQTFLLETPEI 806
E E T +K +K QT E E+
Sbjct: 1203 EQLEQTKRVKANLEKAKQTLENERGEL 1229
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 136 bits (343), Expect = 8e-32
Identities = 175/750 (23%), Positives = 325/750 (43%), Gaps = 124/750 (16%)
Query: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
E E++ KE +LQ+ + E Q+KA EL+ +K S EE
Sbjct: 851 EEEMQAKEDELQKTK---ERQQKAENELKELEQKHSQLTEEK------------------ 889
Query: 184 NLLKETCARSAE-----------------------------------KTKKYEYEREETR 208
NLL+E E + ++ + ER++
Sbjct: 890 NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 949
Query: 209 QVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQV 268
Q +DL +E+ A ++L+++ + ++ KL+++ + + KE E+++
Sbjct: 950 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK-KLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 269 SLLLIQITEKENKMKDLTFLLEESRDKVNQL------EEKTKLQSENLKQSIE-KQHHLT 321
S L + E+E K K+LT L + +++L EEK++ + E LK+ +E
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 322 KELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFE 381
+++ D++ + EE+LQ A + +K +++ + E E
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK-----------IRELE 1117
Query: 382 TTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-------MTKLTNNKEVELE 434
+ L+E L +E+ K E Q + L EL+ +ELE+ +L +E E+
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 435 ELKKVLGEK----ETLLYENKQ-----FEKIAEEL---KGTEQELIGLLQAREKEVHDLE 482
LKK L E+ E + E +Q E++ E+L K + L Q EKE DL
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 483 IQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELK 542
+L + ++Q + K L+ +++ EL S C+ + + E +D +L+
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQ-------ELQSKCS----DGERARAELNDKVHKLQ 1286
Query: 543 NQQEDINNNKKQEE-RMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
N+ E + + E + +K +++ +QL++ E ++EE +QK + V KL + EE
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEER 1345
Query: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLE-------LELESAK 654
N+L+ Q++ + + + L++ L + + K+L + V LE E+E+
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 655 QKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALM 714
Q++ E Y K + K L +E++ V D +L ++K+ Q K +++A
Sbjct: 1406 QQYEEKAAAYDKLEKTK----NRLQQELDDLVVDLDNQRQLVSNLEKK-QRKFDQLLA-- 1458
Query: 715 EKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEK 774
+ K+ K +ERD + KE + SL +LE E K EL K L+ E E+
Sbjct: 1459 -EEKNISSKYADERDRAEAEAREKETKALSLARALE-EALEAKEELERTNKMLKAEMEDL 1516
Query: 775 EKLKREAKENTATL-KEKKDKKTQTFLLET 803
K + +N L K K+ +TQ ++T
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Score = 133 bits (335), Expect = 7e-31
Identities = 182/825 (22%), Positives = 355/825 (43%), Gaps = 156/825 (18%)
Query: 107 SKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVS---LKLE 163
++LY EAE++ +V A+ ++ E L E +E + Q+LQ +K++ L LE
Sbjct: 900 TELYAEAEEM---RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 164 EGIQE----NKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNI- 218
E ++E + L E L++ ++ K ER+ + DL N+
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016
Query: 219 --EKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQ----------EYKKEINDKEK 266
E+ +L+ + E+ E+ +LK++ + Q LE+ ++ ++I D +
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 267 QVSLLLIQITEKENKMK-DLTFLLEESRDKVNQLEEKTKLQ------SENL------KQS 313
Q++ L +Q+ +KE +++ L L +E K N L++ +L+ E+L +
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 314 IEKQ-HHLTKELEDIKVSLQ---RSVSTQKAL----EEDLQIATKTICQLTEEKETQMEE 365
EKQ L +ELE +K L+ S +TQ+ L E+++ + K + + T E Q++E
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 366 SNKARAAHSFVVTE----FETTVCSLEE-----------------LLRTEQQRLEKNEDQ 404
+ A +TE F+ +L++ +L +Q +E + +
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 405 LKILTMELQKKSS------------------ELEEMTKLTNNKEVELEELKKVLGE---- 442
L+ ELQ K S E+E +T + N E + +L K +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 443 ----KETLLYENKQFEKIAEELKGTEQELIGL----------LQAREKEVHDLEIQLTAI 488
+E L E +Q ++ +L+ E+E L Q E+ + L IQL+
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 489 TTSEQYYSKEV-------KDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Q ++ V K + E+EN + E + +KL L QE D+ ++L
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436
Query: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
NQ++ ++N +K++ + QL E + + + +RD + + + E
Sbjct: 1437 DNQRQLVSNLEKKQRKF-----------DQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 602 NNLRKQVENKNKYIEELQQENKALKKK-----GTAESKQLNVYEIKVNK--LELELESAK 654
+L + +E + EEL++ NK LK + + + NV+E++ +K LE ++E K
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 655 QKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALM 714
+ E+ D Q + K E N+ + K + D + ++ +KR Q +
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQ---------L 1594
Query: 715 EKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEI--------------ELSNLKAEL 760
++ H+Y+ +E+ + L + +++ LE+ +L L+A++
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 761 LSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPE 805
+++LE R ++++ AKEN EKK K + L++ E
Sbjct: 1655 KDFQRELEDARASRDEIFATAKEN-----EKKAKSLEADLMQLQE 1694
Score = 120 bits (300), Expect = 8e-27
Identities = 171/810 (21%), Positives = 343/810 (42%), Gaps = 106/810 (13%)
Query: 36 KSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSD 95
++ + TE +F AK NL KN + ++ + A
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENA---------------------------- 1234
Query: 96 LENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGN 155
+ G RV + +E E KK EA++++ +SK + +A EL N
Sbjct: 1235 --DLAGELRVLGQAKQEVEHKKK---KLEAQVQELQSKCSDG-------ERARAEL---N 1279
Query: 156 EKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLN 215
+KV KL+ ++ ++ N A L K+ + S++ E +EETRQ
Sbjct: 1280 DKVH-KLQNEVESVTGML--NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ------ 1330
Query: 216 NNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQI 275
+ +LR Q E R + +L E+ E Q+L E+ +S L IQ+
Sbjct: 1331 -----KLNVSTKLR-QLEEERNSLQDQLDEEMEAKQNL-----------ERHISTLNIQL 1373
Query: 276 TEKENKMKDLTF---LLEESRDKVNQLEEKTKLQSENLKQSIEK----QHHLTKELEDIK 328
++ + K++D LEE + + + E Q E + +K ++ L +EL+D+
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 329 VSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLE 388
V L Q+ L +L+ + QL E++ + R E ET SL
Sbjct: 1434 VDL----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 389 ELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLY 448
L + E+ E K+L E++ S +++ K + ELE+ K+ L ET +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH----ELEKSKRAL---ETQME 1542
Query: 449 ENK-QFEKIAEELKGTEQELIGL---LQAREKEV-HDLEIQLTAITTSEQYYSKEVKDLK 503
E K Q E++ +EL+ TE + L +QA + + DL+ + + +++ + +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 504 TELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE 563
TELE+E+ + + KL + K+L + +K ++E I +K + +M K +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADS---AIKGREEAIKQLRKLQAQM-KDFQ 1658
Query: 564 NLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENK 623
E R+E+ +E ++K ++ L + +E+ + + + EEL +E
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 624 ALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE 683
+ A + E ++ +LE ELE + ++D +K + + L E
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 684 KAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQS 743
A+ +L+++ +K + K+ EM + K ++ I ++++ + + ++++
Sbjct: 1779 TAQKNESARQQLERQ-NKELRSKLHEMEGAV---KSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 744 SLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLK------EKKDKKTQ 797
+ + L +L + Q+E ER+ E+ K +A++ A +K E+ ++++Q
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
Query: 798 TFLLETPEIYWKLDSKAVPSQTVSRNFTSV 827
++ +LD ++ + R ++
Sbjct: 1895 RINANRRKLQRELDEATESNEAMGREVNAL 1924
Score = 114 bits (284), Expect = 6e-25
Identities = 162/782 (20%), Positives = 330/782 (42%), Gaps = 137/782 (17%)
Query: 225 FEELRVQAENSRLEMHFKLKED-YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMK 283
F +++ + +R E + KED +K + +Q+ + E+ + E++ S Q+TE++N
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHS----QLTEEKN--- 890
Query: 284 DLTFLLEESRDKVNQLEEKTKLQSE----NLKQSIEKQHHLTKELEDIKVSLQRSVSTQK 339
LL+E QL+ +T+L +E ++ + +KQ ELE+I ++ + ++
Sbjct: 891 ----LLQE------QLQAETELYAEAEEMRVRLAAKKQ-----ELEEILHEMEARLEEEE 935
Query: 340 ALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEE---LLRTEQQ 396
+ LQ K + Q + E Q+EE AR E + LE+ ++ +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995
Query: 397 RLEKN----EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQ 452
+L K E+++ LT L ++ + + +TKL N E + EL+ L ++E ++
Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK---SRQE 1052
Query: 453 FEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLK 512
EK+ +L+G + + + ++ +L++QL Q + D + N K
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 513 NTELTSHC--------------NKLSLENKELTQETSDMTLELKN------QQEDINNNK 552
EL H NK + ++L +E + EL++ Q+++ +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 553 KQEERMLK------------QIENLQETETQLRNELEYVREELKQKR---DEVKCKLDKS 597
+QE +LK Q++ +++ Q EL E+ K+ + D+ K L+K
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 598 EEN-------CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELEL 650
+ +++VE+K K +E QE ++ G +LN KV+KL+ E+
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN---DKVHKLQNEV 1289
Query: 651 ESAKQKFGE------------------ITDTYQ----------------KEIEDKKISEE 676
ES E + DT + +++E+++ S +
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 677 NLLEEVEKAKVIAD---EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIE----ERD 729
+ L+E +AK + + +Q K+ A V +E+ K ++ K IE + +
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Query: 730 SELGLYKSKEQEQSSLRASLE---IELSNLKAELLSV-KKQLEIER---EEKEKLKREAK 782
+ Y E+ ++ L+ L+ ++L N + + ++ KKQ + ++ EEK + A
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 783 ENTATLKEKKDKKTQTFLL-----ETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRD 837
E E ++K+T+ L E E +L+ + + S + K+ +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 838 YLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSET 897
+K L T + + T + +LQ E+ + +E + + K FE D+ + +
Sbjct: 1530 L--EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 898 TD 899
+
Sbjct: 1588 EE 1589
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 136 bits (343), Expect = 8e-32
Identities = 175/750 (23%), Positives = 325/750 (43%), Gaps = 124/750 (16%)
Query: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
E E++ KE +LQ+ + E Q+KA EL+ +K S EE
Sbjct: 858 EEEMQAKEDELQKTK---ERQQKAENELKELEQKHSQLTEEK------------------ 896
Query: 184 NLLKETCARSAE-----------------------------------KTKKYEYEREETR 208
NLL+E E + ++ + ER++
Sbjct: 897 NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 956
Query: 209 QVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQV 268
Q +DL +E+ A ++L+++ + ++ KL+++ + + KE E+++
Sbjct: 957 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK-KLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 269 SLLLIQITEKENKMKDLTFLLEESRDKVNQL------EEKTKLQSENLKQSIE-KQHHLT 321
S L + E+E K K+LT L + +++L EEK++ + E LK+ +E
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 322 KELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFE 381
+++ D++ + EE+LQ A + +K +++ + E E
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK-----------IRELE 1124
Query: 382 TTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-------MTKLTNNKEVELE 434
+ L+E L +E+ K E Q + L EL+ +ELE+ +L +E E+
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 435 ELKKVLGEK----ETLLYENKQ-----FEKIAEEL---KGTEQELIGLLQAREKEVHDLE 482
LKK L E+ E + E +Q E++ E+L K + L Q EKE DL
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 483 IQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELK 542
+L + ++Q + K L+ +++ EL S C+ + + E +D +L+
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQ-------ELQSKCS----DGERARAELNDKVHKLQ 1293
Query: 543 NQQEDINNNKKQEE-RMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
N+ E + + E + +K +++ +QL++ E ++EE +QK + V KL + EE
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEER 1352
Query: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLE-------LELESAK 654
N+L+ Q++ + + + L++ L + + K+L + V LE E+E+
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 655 QKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALM 714
Q++ E Y K + K L +E++ V D +L ++K+ Q K +++A
Sbjct: 1413 QQYEEKAAAYDKLEKTK----NRLQQELDDLVVDLDNQRQLVSNLEKK-QRKFDQLLA-- 1465
Query: 715 EKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEK 774
+ K+ K +ERD + KE + SL +LE E K EL K L+ E E+
Sbjct: 1466 -EEKNISSKYADERDRAEAEAREKETKALSLARALE-EALEAKEELERTNKMLKAEMEDL 1523
Query: 775 EKLKREAKENTATL-KEKKDKKTQTFLLET 803
K + +N L K K+ +TQ ++T
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Score = 133 bits (335), Expect = 7e-31
Identities = 182/825 (22%), Positives = 355/825 (43%), Gaps = 156/825 (18%)
Query: 107 SKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVS---LKLE 163
++LY EAE++ +V A+ ++ E L E +E + Q+LQ +K++ L LE
Sbjct: 907 TELYAEAEEM---RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 164 EGIQE----NKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNI- 218
E ++E + L E L++ ++ K ER+ + DL N+
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023
Query: 219 --EKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQ----------EYKKEINDKEK 266
E+ +L+ + E+ E+ +LK++ + Q LE+ ++ ++I D +
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 267 QVSLLLIQITEKENKMK-DLTFLLEESRDKVNQLEEKTKLQ------SENL------KQS 313
Q++ L +Q+ +KE +++ L L +E K N L++ +L+ E+L +
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 314 IEKQ-HHLTKELEDIKVSLQ---RSVSTQKAL----EEDLQIATKTICQLTEEKETQMEE 365
EKQ L +ELE +K L+ S +TQ+ L E+++ + K + + T E Q++E
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 366 SNKARAAHSFVVTE----FETTVCSLEE-----------------LLRTEQQRLEKNEDQ 404
+ A +TE F+ +L++ +L +Q +E + +
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 405 LKILTMELQKKSS------------------ELEEMTKLTNNKEVELEELKKVLGE---- 442
L+ ELQ K S E+E +T + N E + +L K +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 443 ----KETLLYENKQFEKIAEELKGTEQELIGL----------LQAREKEVHDLEIQLTAI 488
+E L E +Q ++ +L+ E+E L Q E+ + L IQL+
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 489 TTSEQYYSKEV-------KDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Q ++ V K + E+EN + E + +KL L QE D+ ++L
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443
Query: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
NQ++ ++N +K++ + QL E + + + +RD + + + E
Sbjct: 1444 DNQRQLVSNLEKKQRKF-----------DQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 602 NNLRKQVENKNKYIEELQQENKALKKK-----GTAESKQLNVYEIKVNK--LELELESAK 654
+L + +E + EEL++ NK LK + + + NV+E++ +K LE ++E K
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 655 QKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALM 714
+ E+ D Q + K E N+ + K + D + ++ +KR Q +
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQ---------L 1601
Query: 715 EKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEI--------------ELSNLKAEL 760
++ H+Y+ +E+ + L + +++ LE+ +L L+A++
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 761 LSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPE 805
+++LE R ++++ AKEN EKK K + L++ E
Sbjct: 1662 KDFQRELEDARASRDEIFATAKEN-----EKKAKSLEADLMQLQE 1701
Score = 120 bits (300), Expect = 8e-27
Identities = 171/810 (21%), Positives = 343/810 (42%), Gaps = 106/810 (13%)
Query: 36 KSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSD 95
++ + TE +F AK NL KN + ++ + A
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENA---------------------------- 1241
Query: 96 LENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGN 155
+ G RV + +E E KK EA++++ +SK + +A EL N
Sbjct: 1242 --DLAGELRVLGQAKQEVEHKKK---KLEAQVQELQSKCSDG-------ERARAEL---N 1286
Query: 156 EKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLN 215
+KV KL+ ++ ++ N A L K+ + S++ E +EETRQ
Sbjct: 1287 DKVH-KLQNEVESVTGML--NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ------ 1337
Query: 216 NNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQI 275
+ +LR Q E R + +L E+ E Q+L E+ +S L IQ+
Sbjct: 1338 -----KLNVSTKLR-QLEEERNSLQDQLDEEMEAKQNL-----------ERHISTLNIQL 1380
Query: 276 TEKENKMKDLTF---LLEESRDKVNQLEEKTKLQSENLKQSIEK----QHHLTKELEDIK 328
++ + K++D LEE + + + E Q E + +K ++ L +EL+D+
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 329 VSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLE 388
V L Q+ L +L+ + QL E++ + R E ET SL
Sbjct: 1441 VDL----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 389 ELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLY 448
L + E+ E K+L E++ S +++ K + ELE+ K+ L ET +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH----ELEKSKRAL---ETQME 1549
Query: 449 ENK-QFEKIAEELKGTEQELIGL---LQAREKEV-HDLEIQLTAITTSEQYYSKEVKDLK 503
E K Q E++ +EL+ TE + L +QA + + DL+ + + +++ + +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 504 TELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE 563
TELE+E+ + + KL + K+L + +K ++E I +K + +M K +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADS---AIKGREEAIKQLRKLQAQM-KDFQ 1665
Query: 564 NLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENK 623
E R+E+ +E ++K ++ L + +E+ + + + EEL +E
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 624 ALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE 683
+ A + E ++ +LE ELE + ++D +K + + L E
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 684 KAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQS 743
A+ +L+++ +K + K+ EM + K ++ I ++++ + + ++++
Sbjct: 1786 TAQKNESARQQLERQ-NKELRSKLHEMEGAV---KSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 744 SLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLK------EKKDKKTQ 797
+ + L +L + Q+E ER+ E+ K +A++ A +K E+ ++++Q
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
Query: 798 TFLLETPEIYWKLDSKAVPSQTVSRNFTSV 827
++ +LD ++ + R ++
Sbjct: 1902 RINANRRKLQRELDEATESNEAMGREVNAL 1931
Score = 114 bits (284), Expect = 6e-25
Identities = 162/782 (20%), Positives = 330/782 (42%), Gaps = 137/782 (17%)
Query: 225 FEELRVQAENSRLEMHFKLKED-YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMK 283
F +++ + +R E + KED +K + +Q+ + E+ + E++ S Q+TE++N
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHS----QLTEEKN--- 897
Query: 284 DLTFLLEESRDKVNQLEEKTKLQSE----NLKQSIEKQHHLTKELEDIKVSLQRSVSTQK 339
LL+E QL+ +T+L +E ++ + +KQ ELE+I ++ + ++
Sbjct: 898 ----LLQE------QLQAETELYAEAEEMRVRLAAKKQ-----ELEEILHEMEARLEEEE 942
Query: 340 ALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEE---LLRTEQQ 396
+ LQ K + Q + E Q+EE AR E + LE+ ++ +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002
Query: 397 RLEKN----EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQ 452
+L K E+++ LT L ++ + + +TKL N E + EL+ L ++E ++
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK---SRQE 1059
Query: 453 FEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLK 512
EK+ +L+G + + + ++ +L++QL Q + D + N K
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 513 NTELTSHC--------------NKLSLENKELTQETSDMTLELKN------QQEDINNNK 552
EL H NK + ++L +E + EL++ Q+++ +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 553 KQEERMLK------------QIENLQETETQLRNELEYVREELKQKR---DEVKCKLDKS 597
+QE +LK Q++ +++ Q EL E+ K+ + D+ K L+K
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 598 EEN-------CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELEL 650
+ +++VE+K K +E QE ++ G +LN KV+KL+ E+
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN---DKVHKLQNEV 1296
Query: 651 ESAKQKFGE------------------ITDTYQ----------------KEIEDKKISEE 676
ES E + DT + +++E+++ S +
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 677 NLLEEVEKAKVIAD---EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIE----ERD 729
+ L+E +AK + + +Q K+ A V +E+ K ++ K IE + +
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Query: 730 SELGLYKSKEQEQSSLRASLE---IELSNLKAELLSV-KKQLEIER---EEKEKLKREAK 782
+ Y E+ ++ L+ L+ ++L N + + ++ KKQ + ++ EEK + A
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 783 ENTATLKEKKDKKTQTFLL-----ETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRD 837
E E ++K+T+ L E E +L+ + + S + K+ +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 838 YLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSET 897
+K L T + + T + +LQ E+ + +E + + K FE D+ + +
Sbjct: 1537 L--EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 898 TD 899
+
Sbjct: 1595 EE 1596
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 136 bits (343), Expect = 8e-32
Identities = 175/750 (23%), Positives = 325/750 (43%), Gaps = 124/750 (16%)
Query: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
E E++ KE +LQ+ + E Q+KA EL+ +K S EE
Sbjct: 858 EEEMQAKEDELQKTK---ERQQKAENELKELEQKHSQLTEEK------------------ 896
Query: 184 NLLKETCARSAE-----------------------------------KTKKYEYEREETR 208
NLL+E E + ++ + ER++
Sbjct: 897 NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 956
Query: 209 QVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQV 268
Q +DL +E+ A ++L+++ + ++ KL+++ + + KE E+++
Sbjct: 957 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK-KLEDEILVMDDQNNKLSKERKLLEERI 1015
Query: 269 SLLLIQITEKENKMKDLTFLLEESRDKVNQL------EEKTKLQSENLKQSIE-KQHHLT 321
S L + E+E K K+LT L + +++L EEK++ + E LK+ +E
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 322 KELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFE 381
+++ D++ + EE+LQ A + +K +++ + E E
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK-----------IRELE 1124
Query: 382 TTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-------MTKLTNNKEVELE 434
+ L+E L +E+ K E Q + L EL+ +ELE+ +L +E E+
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 435 ELKKVLGEK----ETLLYENKQ-----FEKIAEEL---KGTEQELIGLLQAREKEVHDLE 482
LKK L E+ E + E +Q E++ E+L K + L Q EKE DL
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1244
Query: 483 IQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELK 542
+L + ++Q + K L+ +++ EL S C+ + + E +D +L+
Sbjct: 1245 GELRVLGQAKQEVEHKKKKLEAQVQ-------ELQSKCS----DGERARAELNDKVHKLQ 1293
Query: 543 NQQEDINNNKKQEE-RMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
N+ E + + E + +K +++ +QL++ E ++EE +QK + V KL + EE
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEER 1352
Query: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLE-------LELESAK 654
N+L+ Q++ + + + L++ L + + K+L + V LE E+E+
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 655 QKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALM 714
Q++ E Y K + K L +E++ V D +L ++K+ Q K +++A
Sbjct: 1413 QQYEEKAAAYDKLEKTK----NRLQQELDDLVVDLDNQRQLVSNLEKK-QRKFDQLLA-- 1465
Query: 715 EKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEK 774
+ K+ K +ERD + KE + SL +LE E K EL K L+ E E+
Sbjct: 1466 -EEKNISSKYADERDRAEAEAREKETKALSLARALE-EALEAKEELERTNKMLKAEMEDL 1523
Query: 775 EKLKREAKENTATL-KEKKDKKTQTFLLET 803
K + +N L K K+ +TQ ++T
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Score = 133 bits (335), Expect = 7e-31
Identities = 182/825 (22%), Positives = 355/825 (43%), Gaps = 156/825 (18%)
Query: 107 SKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVS---LKLE 163
++LY EAE++ +V A+ ++ E L E +E + Q+LQ +K++ L LE
Sbjct: 907 TELYAEAEEM---RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 164 EGIQE----NKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNI- 218
E ++E + L E L++ ++ K ER+ + DL N+
Sbjct: 964 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023
Query: 219 --EKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQ----------EYKKEINDKEK 266
E+ +L+ + E+ E+ +LK++ + Q LE+ ++ ++I D +
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 267 QVSLLLIQITEKENKMK-DLTFLLEESRDKVNQLEEKTKLQ------SENL------KQS 313
Q++ L +Q+ +KE +++ L L +E K N L++ +L+ E+L +
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1143
Query: 314 IEKQ-HHLTKELEDIKVSLQ---RSVSTQKAL----EEDLQIATKTICQLTEEKETQMEE 365
EKQ L +ELE +K L+ S +TQ+ L E+++ + K + + T E Q++E
Sbjct: 1144 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 366 SNKARAAHSFVVTE----FETTVCSLEE-----------------LLRTEQQRLEKNEDQ 404
+ A +TE F+ +L++ +L +Q +E + +
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 405 LKILTMELQKKSS------------------ELEEMTKLTNNKEVELEELKKVLGE---- 442
L+ ELQ K S E+E +T + N E + +L K +
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 443 ----KETLLYENKQFEKIAEELKGTEQELIGL----------LQAREKEVHDLEIQLTAI 488
+E L E +Q ++ +L+ E+E L Q E+ + L IQL+
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1383
Query: 489 TTSEQYYSKEV-------KDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Q ++ V K + E+EN + E + +KL L QE D+ ++L
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1443
Query: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
NQ++ ++N +K++ + QL E + + + +RD + + + E
Sbjct: 1444 DNQRQLVSNLEKKQRKF-----------DQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 602 NNLRKQVENKNKYIEELQQENKALKKK-----GTAESKQLNVYEIKVNK--LELELESAK 654
+L + +E + EEL++ NK LK + + + NV+E++ +K LE ++E K
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 655 QKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALM 714
+ E+ D Q + K E N+ + K + D + ++ +KR Q +
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQ---------L 1601
Query: 715 EKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEI--------------ELSNLKAEL 760
++ H+Y+ +E+ + L + +++ LE+ +L L+A++
Sbjct: 1602 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Query: 761 LSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPE 805
+++LE R ++++ AKEN EKK K + L++ E
Sbjct: 1662 KDFQRELEDARASRDEIFATAKEN-----EKKAKSLEADLMQLQE 1701
Score = 120 bits (300), Expect = 8e-27
Identities = 171/810 (21%), Positives = 343/810 (42%), Gaps = 106/810 (13%)
Query: 36 KSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSD 95
++ + TE +F AK NL KN + ++ + A
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENA---------------------------- 1241
Query: 96 LENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGN 155
+ G RV + +E E KK EA++++ +SK + +A EL N
Sbjct: 1242 --DLAGELRVLGQAKQEVEHKKK---KLEAQVQELQSKCSDG-------ERARAEL---N 1286
Query: 156 EKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLN 215
+KV KL+ ++ ++ N A L K+ + S++ E +EETRQ
Sbjct: 1287 DKVH-KLQNEVESVTGML--NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ------ 1337
Query: 216 NNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQI 275
+ +LR Q E R + +L E+ E Q+L E+ +S L IQ+
Sbjct: 1338 -----KLNVSTKLR-QLEEERNSLQDQLDEEMEAKQNL-----------ERHISTLNIQL 1380
Query: 276 TEKENKMKDLTF---LLEESRDKVNQLEEKTKLQSENLKQSIEK----QHHLTKELEDIK 328
++ + K++D LEE + + + E Q E + +K ++ L +EL+D+
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 329 VSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLE 388
V L Q+ L +L+ + QL E++ + R E ET SL
Sbjct: 1441 VDL----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 389 ELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLY 448
L + E+ E K+L E++ S +++ K + ELE+ K+ L ET +
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH----ELEKSKRAL---ETQME 1549
Query: 449 ENK-QFEKIAEELKGTEQELIGL---LQAREKEV-HDLEIQLTAITTSEQYYSKEVKDLK 503
E K Q E++ +EL+ TE + L +QA + + DL+ + + +++ + +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 504 TELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE 563
TELE+E+ + + KL + K+L + +K ++E I +K + +M K +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADS---AIKGREEAIKQLRKLQAQM-KDFQ 1665
Query: 564 NLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENK 623
E R+E+ +E ++K ++ L + +E+ + + + EEL +E
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 624 ALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE 683
+ A + E ++ +LE ELE + ++D +K + + L E
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 684 KAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQS 743
A+ +L+++ +K + K+ EM + K ++ I ++++ + + ++++
Sbjct: 1786 TAQKNESARQQLERQ-NKELRSKLHEMEGAV---KSKFKSTIAALEAKIAQLEEQVEQEA 1841
Query: 744 SLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLK------EKKDKKTQ 797
+ + L +L + Q+E ER+ E+ K +A++ A +K E+ ++++Q
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
Query: 798 TFLLETPEIYWKLDSKAVPSQTVSRNFTSV 827
++ +LD ++ + R ++
Sbjct: 1902 RINANRRKLQRELDEATESNEAMGREVNAL 1931
Score = 114 bits (284), Expect = 6e-25
Identities = 162/782 (20%), Positives = 330/782 (42%), Gaps = 137/782 (17%)
Query: 225 FEELRVQAENSRLEMHFKLKED-YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMK 283
F +++ + +R E + KED +K + +Q+ + E+ + E++ S Q+TE++N
Sbjct: 845 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHS----QLTEEKN--- 897
Query: 284 DLTFLLEESRDKVNQLEEKTKLQSE----NLKQSIEKQHHLTKELEDIKVSLQRSVSTQK 339
LL+E QL+ +T+L +E ++ + +KQ ELE+I ++ + ++
Sbjct: 898 ----LLQE------QLQAETELYAEAEEMRVRLAAKKQ-----ELEEILHEMEARLEEEE 942
Query: 340 ALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEE---LLRTEQQ 396
+ LQ K + Q + E Q+EE AR E + LE+ ++ +
Sbjct: 943 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 1002
Query: 397 RLEKN----EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQ 452
+L K E+++ LT L ++ + + +TKL N E + EL+ L ++E ++
Sbjct: 1003 KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK---SRQE 1059
Query: 453 FEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLK 512
EK+ +L+G + + + ++ +L++QL Q + D + N K
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1119
Query: 513 NTELTSHC--------------NKLSLENKELTQETSDMTLELKN------QQEDINNNK 552
EL H NK + ++L +E + EL++ Q+++ +
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 553 KQEERMLK------------QIENLQETETQLRNELEYVREELKQKR---DEVKCKLDKS 597
+QE +LK Q++ +++ Q EL E+ K+ + D+ K L+K
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 598 EEN-------CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELEL 650
+ +++VE+K K +E QE ++ G +LN KV+KL+ E+
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN---DKVHKLQNEV 1296
Query: 651 ESAKQKFGE------------------ITDTYQ----------------KEIEDKKISEE 676
ES E + DT + +++E+++ S +
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356
Query: 677 NLLEEVEKAKVIAD---EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIE----ERD 729
+ L+E +AK + + +Q K+ A V +E+ K ++ K IE + +
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416
Query: 730 SELGLYKSKEQEQSSLRASLE---IELSNLKAELLSV-KKQLEIER---EEKEKLKREAK 782
+ Y E+ ++ L+ L+ ++L N + + ++ KKQ + ++ EEK + A
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 783 ENTATLKEKKDKKTQTFLL-----ETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRD 837
E E ++K+T+ L E E +L+ + + S + K+ +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 838 YLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSET 897
+K L T + + T + +LQ E+ + +E + + K FE D+ + +
Sbjct: 1537 L--EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 898 TD 899
+
Sbjct: 1595 EE 1596
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 136 bits (343), Expect = 8e-32
Identities = 175/750 (23%), Positives = 325/750 (43%), Gaps = 124/750 (16%)
Query: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
E E++ KE +LQ+ + E Q+KA EL+ +K S EE
Sbjct: 851 EEEMQAKEDELQKTK---ERQQKAENELKELEQKHSQLTEEK------------------ 889
Query: 184 NLLKETCARSAE-----------------------------------KTKKYEYEREETR 208
NLL+E E + ++ + ER++
Sbjct: 890 NLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA 949
Query: 209 QVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQV 268
Q +DL +E+ A ++L+++ + ++ KL+++ + + KE E+++
Sbjct: 950 QQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK-KLEDEILVMDDQNNKLSKERKLLEERI 1008
Query: 269 SLLLIQITEKENKMKDLTFLLEESRDKVNQL------EEKTKLQSENLKQSIE-KQHHLT 321
S L + E+E K K+LT L + +++L EEK++ + E LK+ +E
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 322 KELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFE 381
+++ D++ + EE+LQ A + +K +++ + E E
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK-----------IRELE 1117
Query: 382 TTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-------MTKLTNNKEVELE 434
+ L+E L +E+ K E Q + L EL+ +ELE+ +L +E E+
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 435 ELKKVLGEK----ETLLYENKQ-----FEKIAEEL---KGTEQELIGLLQAREKEVHDLE 482
LKK L E+ E + E +Q E++ E+L K + L Q EKE DL
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA 1237
Query: 483 IQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELK 542
+L + ++Q + K L+ +++ EL S C+ + + E +D +L+
Sbjct: 1238 GELRVLGQAKQEVEHKKKKLEAQVQ-------ELQSKCS----DGERARAELNDKVHKLQ 1286
Query: 543 NQQEDINNNKKQEE-RMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
N+ E + + E + +K +++ +QL++ E ++EE +QK + V KL + EE
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEER 1345
Query: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLE-------LELESAK 654
N+L+ Q++ + + + L++ L + + K+L + V LE E+E+
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 655 QKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALM 714
Q++ E Y K + K L +E++ V D +L ++K+ Q K +++A
Sbjct: 1406 QQYEEKAAAYDKLEKTK----NRLQQELDDLVVDLDNQRQLVSNLEKK-QRKFDQLLA-- 1458
Query: 715 EKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEK 774
+ K+ K +ERD + KE + SL +LE E K EL K L+ E E+
Sbjct: 1459 -EEKNISSKYADERDRAEAEAREKETKALSLARALE-EALEAKEELERTNKMLKAEMEDL 1516
Query: 775 EKLKREAKENTATL-KEKKDKKTQTFLLET 803
K + +N L K K+ +TQ ++T
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Score = 133 bits (335), Expect = 7e-31
Identities = 182/825 (22%), Positives = 355/825 (43%), Gaps = 156/825 (18%)
Query: 107 SKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVS---LKLE 163
++LY EAE++ +V A+ ++ E L E +E + Q+LQ +K++ L LE
Sbjct: 900 TELYAEAEEM---RVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 164 EGIQE----NKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNI- 218
E ++E + L E L++ ++ K ER+ + DL N+
Sbjct: 957 EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016
Query: 219 --EKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQ----------EYKKEINDKEK 266
E+ +L+ + E+ E+ +LK++ + Q LE+ ++ ++I D +
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 267 QVSLLLIQITEKENKMK-DLTFLLEESRDKVNQLEEKTKLQ------SENL------KQS 313
Q++ L +Q+ +KE +++ L L +E K N L++ +L+ E+L +
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 314 IEKQ-HHLTKELEDIKVSLQ---RSVSTQKAL----EEDLQIATKTICQLTEEKETQMEE 365
EKQ L +ELE +K L+ S +TQ+ L E+++ + K + + T E Q++E
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 366 SNKARAAHSFVVTE----FETTVCSLEE-----------------LLRTEQQRLEKNEDQ 404
+ A +TE F+ +L++ +L +Q +E + +
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 405 LKILTMELQKKSS------------------ELEEMTKLTNNKEVELEELKKVLGE---- 442
L+ ELQ K S E+E +T + N E + +L K +
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 443 ----KETLLYENKQFEKIAEELKGTEQELIGL----------LQAREKEVHDLEIQLTAI 488
+E L E +Q ++ +L+ E+E L Q E+ + L IQL+
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 489 TTSEQYYSKEV-------KDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL 541
Q ++ V K + E+EN + E + +KL L QE D+ ++L
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL 1436
Query: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
NQ++ ++N +K++ + QL E + + + +RD + + + E
Sbjct: 1437 DNQRQLVSNLEKKQRKF-----------DQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 602 NNLRKQVENKNKYIEELQQENKALKKK-----GTAESKQLNVYEIKVNK--LELELESAK 654
+L + +E + EEL++ NK LK + + + NV+E++ +K LE ++E K
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 655 QKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALM 714
+ E+ D Q + K E N+ + K + D + ++ +KR Q +
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNM--QALKGQFERDLQARDEQNEEKRRQ---------L 1594
Query: 715 EKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEI--------------ELSNLKAEL 760
++ H+Y+ +E+ + L + +++ LE+ +L L+A++
Sbjct: 1595 QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Query: 761 LSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPE 805
+++LE R ++++ AKEN EKK K + L++ E
Sbjct: 1655 KDFQRELEDARASRDEIFATAKEN-----EKKAKSLEADLMQLQE 1694
Score = 120 bits (300), Expect = 8e-27
Identities = 171/810 (21%), Positives = 343/810 (42%), Gaps = 106/810 (13%)
Query: 36 KSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSD 95
++ + TE +F AK NL KN + ++ + A
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENA---------------------------- 1234
Query: 96 LENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGN 155
+ G RV + +E E KK EA++++ +SK + +A EL N
Sbjct: 1235 --DLAGELRVLGQAKQEVEHKKK---KLEAQVQELQSKCSDG-------ERARAEL---N 1279
Query: 156 EKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLN 215
+KV KL+ ++ ++ N A L K+ + S++ E +EETRQ
Sbjct: 1280 DKVH-KLQNEVESVTGML--NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ------ 1330
Query: 216 NNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQI 275
+ +LR Q E R + +L E+ E Q+L E+ +S L IQ+
Sbjct: 1331 -----KLNVSTKLR-QLEEERNSLQDQLDEEMEAKQNL-----------ERHISTLNIQL 1373
Query: 276 TEKENKMKDLTF---LLEESRDKVNQLEEKTKLQSENLKQSIEK----QHHLTKELEDIK 328
++ + K++D LEE + + + E Q E + +K ++ L +EL+D+
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 329 VSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLE 388
V L Q+ L +L+ + QL E++ + R E ET SL
Sbjct: 1434 VDL----DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 389 ELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLY 448
L + E+ E K+L E++ S +++ K + ELE+ K+ L ET +
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH----ELEKSKRAL---ETQME 1542
Query: 449 ENK-QFEKIAEELKGTEQELIGL---LQAREKEV-HDLEIQLTAITTSEQYYSKEVKDLK 503
E K Q E++ +EL+ TE + L +QA + + DL+ + + +++ + +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 504 TELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE 563
TELE+E+ + + KL + K+L + +K ++E I +K + +M K +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADS---AIKGREEAIKQLRKLQAQM-KDFQ 1658
Query: 564 NLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENK 623
E R+E+ +E ++K ++ L + +E+ + + + EEL +E
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 624 ALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE 683
+ A + E ++ +LE ELE + ++D +K + + L E
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 684 KAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQS 743
A+ +L+++ +K + K+ EM + K ++ I ++++ + + ++++
Sbjct: 1779 TAQKNESARQQLERQ-NKELRSKLHEMEGAV---KSKFKSTIAALEAKIAQLEEQVEQEA 1834
Query: 744 SLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLK------EKKDKKTQ 797
+ + L +L + Q+E ER+ E+ K +A++ A +K E+ ++++Q
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
Query: 798 TFLLETPEIYWKLDSKAVPSQTVSRNFTSV 827
++ +LD ++ + R ++
Sbjct: 1895 RINANRRKLQRELDEATESNEAMGREVNAL 1924
Score = 114 bits (284), Expect = 6e-25
Identities = 162/782 (20%), Positives = 330/782 (42%), Gaps = 137/782 (17%)
Query: 225 FEELRVQAENSRLEMHFKLKED-YEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMK 283
F +++ + +R E + KED +K + +Q+ + E+ + E++ S Q+TE++N
Sbjct: 838 FTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHS----QLTEEKN--- 890
Query: 284 DLTFLLEESRDKVNQLEEKTKLQSE----NLKQSIEKQHHLTKELEDIKVSLQRSVSTQK 339
LL+E QL+ +T+L +E ++ + +KQ ELE+I ++ + ++
Sbjct: 891 ----LLQE------QLQAETELYAEAEEMRVRLAAKKQ-----ELEEILHEMEARLEEEE 935
Query: 340 ALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEE---LLRTEQQ 396
+ LQ K + Q + E Q+EE AR E + LE+ ++ +
Sbjct: 936 DRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNN 995
Query: 397 RLEKN----EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQ 452
+L K E+++ LT L ++ + + +TKL N E + EL+ L ++E ++
Sbjct: 996 KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEK---SRQE 1052
Query: 453 FEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLK 512
EK+ +L+G + + + ++ +L++QL Q + D + N K
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKK 1112
Query: 513 NTELTSHC--------------NKLSLENKELTQETSDMTLELKN------QQEDINNNK 552
EL H NK + ++L +E + EL++ Q+++ +
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 553 KQEERMLK------------QIENLQETETQLRNELEYVREELKQKR---DEVKCKLDKS 597
+QE +LK Q++ +++ Q EL E+ K+ + D+ K L+K
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 598 EEN-------CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELEL 650
+ +++VE+K K +E QE ++ G +LN KV+KL+ E+
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN---DKVHKLQNEV 1289
Query: 651 ESAKQKFGE------------------ITDTYQ----------------KEIEDKKISEE 676
ES E + DT + +++E+++ S +
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349
Query: 677 NLLEEVEKAKVIAD---EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIE----ERD 729
+ L+E +AK + + +Q K+ A V +E+ K ++ K IE + +
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409
Query: 730 SELGLYKSKEQEQSSLRASLE---IELSNLKAELLSV-KKQLEIER---EEKEKLKREAK 782
+ Y E+ ++ L+ L+ ++L N + + ++ KKQ + ++ EEK + A
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 783 ENTATLKEKKDKKTQTFLL-----ETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRD 837
E E ++K+T+ L E E +L+ + + S + K+ +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 838 YLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSET 897
+K L T + + T + +LQ E+ + +E + + K FE D+ + +
Sbjct: 1530 L--EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 898 TD 899
+
Sbjct: 1588 EE 1589
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 134 bits (338), Expect = 3e-31
Identities = 172/823 (20%), Positives = 361/823 (43%), Gaps = 139/823 (16%)
Query: 53 TNLSKNGENIDSDPALQKVNFLPVLE-QVGN-----SDCHYQEGLKDSDLENSEGLSRVY 106
T L + E D + +N L L +GN +D + L +S+++N L +
Sbjct: 1909 TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN---LKKCV 1965
Query: 107 SKLYKEAEKIKKWKVSTEAELR----------QKE----SKLQENRKIIEAQRKAIQELQ 152
S+L +E +++ K K E+E+R QKE S +E +++++ +++ +++LQ
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQ 2025
Query: 153 FGNEKVSLKLEEGIQENKDLIKE----NNATRHLCNLLKETCARSAEKTKKYEYEREETR 208
K ++ +E I + +K ++ + KE A++ E KK + E +
Sbjct: 2026 ----KDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFK 2081
Query: 209 QVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQH-LEQEYKKEINDK--- 264
+ D + +++ +L+ + ++++ + ++K+ E ++ LEQ +K + +K
Sbjct: 2082 VLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNM 2141
Query: 265 --------------EKQVSLLLIQITEKENKMKDLT-----------------FLLEESR 293
E+ + + + + +K+ +++ L L++ R
Sbjct: 2142 QEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDR 2201
Query: 294 DKV---------------NQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQ 338
D+V EE+ +L+ +N ++ ++ +E++K+++ R
Sbjct: 2202 DRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISR----- 2256
Query: 339 KALEEDLQI---ATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ 395
LE D QI +T QL ++ ++ NK ++++ E T L + Q
Sbjct: 2257 --LEHDKQIWESKAQTEVQLQQKVCDTLQGENKE------LLSQLEET----RHLYHSSQ 2304
Query: 396 QRLEKNEDQLKILTMELQKKSSELEEMTKLTNN-------KEVELEELKKVLGEKETLLY 448
L K E +LK L +L S+ LE+ + N +E +++ K + ET L
Sbjct: 2305 NELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ 2364
Query: 449 ENKQF-EKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELE 507
+++ ++ EE+ EQ++I LL +E+ + AI Q + KE+K+L+ L
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQ------VAIAELRQQHDKEIKELENLLS 2418
Query: 508 NEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQE 567
E+ +N L ENK+ +T+ + LK +++ K Q + +K + +LQ
Sbjct: 2419 QEEEENIVLEE-------ENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQN 2471
Query: 568 TETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK 627
++ + + + E E + ++ N L++++ ++++L EN L
Sbjct: 2472 DRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKL-- 2529
Query: 628 KGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKV 687
+L Y +N++ +S +++ E+ KE+E+K E L+E E+A
Sbjct: 2530 -----DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE 2584
Query: 688 IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLY----KSKEQE-- 741
+ +E + +I + + + Q + EE LGLY K KE+E
Sbjct: 2585 DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE--GTLGLYHAQLKVKEEEVH 2642
Query: 742 -QSSLRASLEIELSNLKAELLSVKKQLEIE-REEKEKLKREAK 782
S+L +S + ++ L+ EL+ V+K+ + E ++KLK+E K
Sbjct: 2643 RLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELK 2685
Score = 117 bits (293), Expect = 5e-26
Identities = 152/714 (21%), Positives = 304/714 (42%), Gaps = 79/714 (11%)
Query: 148 IQELQFGNEKVSLKLEEGIQENKDLIKE-NNATRHLCNLLKETC-------ARSAEKTKK 199
I L+ E++ KL+E + K ++K+ RHL LK+ + E++K+
Sbjct: 1166 ILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKE 1225
Query: 200 YEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMH-FKLKEDYEKIQHLEQEYK 258
E ++ RQ+ + + +I+ + + ++ + LE FK E + LE
Sbjct: 1226 NENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLC 1285
Query: 259 KEINDKEKQVSLL-----LIQI-----------TEKENKMKDLTFLLEESRDKVNQLEEK 302
+ + S L + QI E E K+ T L + ++V QL+E+
Sbjct: 1286 PDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQ 1345
Query: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEE--DLQIATKTICQLTEEKE 360
Q ++ H E ++ L+ S LE +LQ + +L +KE
Sbjct: 1346 INKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKE 1405
Query: 361 TQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLE----KNEDQLKILTMELQKKS 416
+ + + +T+ +T + E+L++ +LE ++++++K L +EL +
Sbjct: 1406 EDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMK 1465
Query: 417 SELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREK 476
+ EE+ + + K+ +L+ L ++ L ENK ++ +GT + L L E
Sbjct: 1466 QKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVES 1525
Query: 477 EVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSD 536
+V + + +E L TE++ L+N L+S C L L + LT++
Sbjct: 1526 QVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTED--- 1582
Query: 537 MTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDK 596
+E+++K+IE+L+ ++ E + +EL QK E+ L +
Sbjct: 1583 ------------------KEKLVKEIESLKSSKIAESTEWQEKHKEL-QKEYEI---LLQ 1620
Query: 597 SEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQK 656
S EN +N +++++ +E ++QE + L K + E ++ + E E+E K+K
Sbjct: 1621 SYENVSNEAERIQH---VVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEK 1677
Query: 657 FGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEK 716
+ + Q++I + + + L EV A A E ++ + A M +E+
Sbjct: 1678 MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN-------ASMKEELER 1730
Query: 717 HKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELL-SVKKQLEIEREEK- 774
K +Y+ + K Q S + SL E+ +LK ++ +V KQ +E EK
Sbjct: 1731 VKMEYETL-----------SKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKH 1779
Query: 775 EKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVD 828
+ +E T ++ + +++ + P + S + VS++F+S D
Sbjct: 1780 DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHD 1833
Score = 112 bits (281), Expect = 1e-24
Identities = 164/781 (20%), Positives = 323/781 (41%), Gaps = 148/781 (18%)
Query: 100 EGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVS 159
EGL+ KL KE E +K K++ E ++K +LQ+ +I+
Sbjct: 1577 EGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL------------------ 1618
Query: 160 LKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIE 219
+Q +++ E +H+ +++ K + E ++ET + + +E
Sbjct: 1619 ------LQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME 1672
Query: 220 KMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKE 279
+M + +M K +KI LE+E ND+ L ++
Sbjct: 1673 EM--------------KEKMRKFAKSKQQKILELEEE-----NDR------LRAEVHPAG 1707
Query: 280 NKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIE----KQHHLTKELEDIKVSLQRSV 335
+ K+ L S + + E+ K++ E L + + ++ L++E++D+K ++ +V
Sbjct: 1708 DTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNV 1767
Query: 336 STQKALEED---------LQIATKTICQLTEEKE--------TQMEESNKARAAHSFVVT 378
S Q LE + T++I TEE++ T E A++A+ V
Sbjct: 1768 SKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSK 1827
Query: 379 EFET----------------TVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSEL--- 419
+F + + LEE + ++ + E++ L ++ K EL
Sbjct: 1828 DFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKML 1887
Query: 420 -EEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV 478
EE+TK+ + EEL +V KET E E E L EL G + ++V
Sbjct: 1888 QEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLE---ERLMNQLAELNGSIGNYCQDV 1944
Query: 479 HDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLEN----------- 527
D +I+ + + + K V +L+ E + + T++ S K LE
Sbjct: 1945 TDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK 2004
Query: 528 ---KELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELK 584
KEL + + E+K Q+D +++ + + ++ L+ +T+ + +LE +E L
Sbjct: 2005 SHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLA 2064
Query: 585 QKRD----------EVKCKLDKSEEN-----CNNLRKQVE---NKNKYIEELQQENKALK 626
Q + K LD ++ +NL+ + E NK +++Q+++ L+
Sbjct: 2065 QAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124
Query: 627 KK-GTAESKQL----NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEE 681
++ AE K L N+ E K++ L E ++ GEI T K+ ++ + +ENL
Sbjct: 2125 RRLEQAEEKHLKEKKNMQE-KLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST 2183
Query: 682 VEKAKVIADEAVKLQKEID------KRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLY 735
V + LQ + D K+ + K ++ + E+ I ++ +
Sbjct: 2184 VTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEE-------IRLKEDNCSVL 2236
Query: 736 KSKEQEQSSLRASLEIELSNLK--AELLSVKKQLEIEREEK--EKLKREAKENTATLKEK 791
K + ++ S L+I +S L+ ++ K Q E++ ++K + L+ E KE + L+E
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 792 K 792
+
Sbjct: 2297 R 2297
Score = 112 bits (280), Expect = 2e-24
Identities = 192/922 (20%), Positives = 400/922 (43%), Gaps = 110/922 (11%)
Query: 99 SEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKV 158
+E + V + +E +++ STEA ++ E +LQE + +E ++ +++ ++
Sbjct: 1629 AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQK 1688
Query: 159 SLKLEEGIQENKDLIKE----NNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDL 214
L+LEE EN L E + + L + A E+ ++ + E E + + L
Sbjct: 1689 ILELEE---ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSL 1745
Query: 215 NNNIEKMITAFEELRVQAE-NSRLEMHFKLKEDYEKIQHLEQEYKKEI-NDKEKQVSLLL 272
+ + + ++L+ Q E N + + + E ++ ++ +E + I + E+Q SL +
Sbjct: 1746 MSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM 1805
Query: 273 ---------IQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKE 323
+ + N F + + Q ++ K + L++ +K ++
Sbjct: 1806 STRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQT 1865
Query: 324 LEDIKVSLQRSVSTQ----KALEEDL-------QIATKTICQLTEEKETQMEESNKARAA 372
LE+ K +L +ST+ K L+E++ Q + + ++T+ KET EE +
Sbjct: 1866 LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER 1925
Query: 373 HSFVVTEFETTV---CSLEELLRTEQQRLEKNEDQLKILTMELQKKSSEL-EEMTKLTNN 428
+ E ++ C + + + LE LK EL+++ +L +E TK+ +
Sbjct: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVES- 1984
Query: 429 KEVELEELKKVLG-EKETLLYENKQFEKIAEELKGTEQELIGLLQAR----EKEVHDLEI 483
E+ E L+K+ G +KE NK K +EL +Q+ + LQ ++++ LE
Sbjct: 1985 -EIRKEYLEKIQGAQKEP---GNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALER 2040
Query: 484 QLTAITTSEQYYSKEVKDLKTEL----ENEKLKNTELTSHCNKLSLENKELTQETSD--- 536
+ A+ + K+++ K L E+ K EL S L E + +D
Sbjct: 2041 TVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLK 2100
Query: 537 MTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDK 596
+ EL++ +E + + KQ++ L++ L++ E + E + ++E+L R E K L
Sbjct: 2101 LKKELQSNKESVKSQMKQKDEDLER--RLEQAEEKHLKEKKNMQEKLDALRRE-KVHL-- 2155
Query: 597 SEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQK 656
EE ++ + K+K +++LQ+ + + A +K ++ + +++ E + ++K
Sbjct: 2156 -EETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERK 2214
Query: 657 FGEITDTYQKEIEDKKISEENLLEEVEKAKVIADE------AVKLQKEI-DKRCQHKIAE 709
F + + ++EI K+ + L +++ + + +E ++ K+I + + Q ++
Sbjct: 2215 FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQL 2274
Query: 710 MVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEI 769
+ + + + +++ + + LY S + E A LE EL +LK +L + LE
Sbjct: 2275 QQKVCDTLQGENKELLSQLEETRHLYHSSQNE----LAKLESELKSLKDQLTDLSNSLEK 2330
Query: 770 EREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDH 829
+E+K L+ ++ A ++ K Q LET D +A SR TS H
Sbjct: 2331 CKEQKGNLEGIIRQQEADIQNSKFSYEQ---LET-------DLQA------SRELTSRLH 2374
Query: 830 ---GISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQ----QRENLNIPIEESKKKR 882
+ + K L + + + + + +L+ Q E NI +EE KK
Sbjct: 2375 EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKA 2434
Query: 883 KMAFEFDINSDSSETTDLLSMVSEEETLKTLYRNNNPPASHLCVKTPKKAPSSLTTPGST 942
+T L+ ETLKT+ + N + L + K+ SSL
Sbjct: 2435 -----------VDKTNQLM------ETLKTIKKENIQQKAQL--DSFVKSMSSLQNDRDR 2475
Query: 943 LKFGAIRKMREDRWAVIAKMDR 964
+ G +++ E ++I + D+
Sbjct: 2476 I-VGDYQQLEERHLSIILEKDQ 2496
Score = 112 bits (279), Expect = 2e-24
Identities = 171/765 (22%), Positives = 327/765 (42%), Gaps = 98/765 (12%)
Query: 88 QEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKA 147
++GL+ L+ + V+++ ++ + + +++ LR+ + KL E +K+I + +
Sbjct: 1348 KQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEED 1407
Query: 148 IQEL--QFGNEKVSL-KLEEGIQENKDLIK------ENNATRHLCNLLKETCARSAEKTK 198
+ L Q ++ +L K++ I E +DLIK E A H +K+ E +
Sbjct: 1408 VSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEH-DERIKQLQVELCEMKQ 1466
Query: 199 KYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK 258
K E EE+R I++ + A R +A L+ + L+E+ + +
Sbjct: 1467 KPEEIGEESR-----AKQQIQRKLQAALISRKEA----LKENKSLQEELSLARGTIERLT 1517
Query: 259 KEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEK-- 316
K + D E QVS Q EK+ + L LL+E RDK+ +++ L++++L S E
Sbjct: 1518 KSLADVESQVS---AQNKEKDTVLGRLA-LLQEERDKLITEMDRSLLENQSLSSSCESLK 1573
Query: 317 ---------QHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESN 367
+ L KE+E +K S + + ++LQ + + Q E + E
Sbjct: 1574 LALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAE--- 1630
Query: 368 KARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTN 427
R H VV L LR+ + ++ E QL+ E+++ ++ + K
Sbjct: 1631 --RIQH--VVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQ 1686
Query: 428 NKEVELEELKKVLGEKETLLYE----NKQFEKIAEELKGTEQELIGLLQAREKEVHDLEI 483
K +ELEE E + L E ++ E L + + L+ + E L
Sbjct: 1687 QKILELEE------ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSK 1740
Query: 484 QLTAITTSEQYYSKEVKDLKTELEN--EKLKNTELT-SHCNKLSLENKEL------TQET 534
+ ++ + + S+EV+DLK ++E K N E T H N+ ++ + T+E
Sbjct: 1741 KFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQ 1800
Query: 535 SDMTLELK---------------------NQQEDINNNKKQEERMLKQIENLQETETQLR 573
+++ + + ++INN +Q +++ ++I L+E E Q
Sbjct: 1801 DSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEE-EKQKN 1859
Query: 574 NELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQE-NKALKKKGTAE 632
E + L+ +++ + ++ + L+++V N +++Q+E ++ K K TAE
Sbjct: 1860 KEFS---QTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE 1916
Query: 633 SKQLNVYEIKVNKLELELESAKQKFGEITDTYQKE--IEDKKISEENLLEEVEKAK-VIA 689
++ ++ E +N+L S ++TD K +E + + + + E+E+ K +
Sbjct: 1917 EEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLV 1976
Query: 690 DEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASL 749
E K++ EI K KI A E + K ++E L K K+QE L+
Sbjct: 1977 KEKTKVESEIRKEYLEKI--QGAQKEPGNKSHAKELQE------LLKEKQQEVKQLQKDC 2028
Query: 750 EIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDK 794
I + L K LE + E +K KEN A E + K
Sbjct: 2029 -IRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKK 2072
Score = 93.6 bits (231), Expect = 8e-19
Identities = 170/861 (19%), Positives = 345/861 (40%), Gaps = 132/861 (15%)
Query: 92 KDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKA---- 147
++SD+E + + AE++ V + +RQK+ +LQ+ + ++ +RKA
Sbjct: 36 QESDMEFNNTTQEDVQERLAYAEQLV---VELKDIIRQKDVQLQQKDEALQEERKAADNK 92
Query: 148 IQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREET 207
I++L+ + L + I+E +K T + T +S E+ K++ E
Sbjct: 93 IKKLKLHAKAKLTSLNKYIEE----MKAQGGT------VLPTEPQSEEQLSKHDKSSTEE 142
Query: 208 RQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQ 267
+ + +++ L+ Q ++ E + + E+ + K+++ +KE+
Sbjct: 143 EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM----KQQLQEKEEF 198
Query: 268 VSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDI 327
+S L Q+++ + + + R+K + E + +L + L Q +
Sbjct: 199 ISTLQAQLSQTQAEQA----AQQVVREKDARFETQVRLHEDELLQLV------------- 241
Query: 328 KVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSL 387
TQ +E ++Q + + + EE EES RA
Sbjct: 242 ---------TQADVETEMQQKLRVLQRKLEEH----EESLVGRA---------------- 272
Query: 388 EELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLL 447
+++ QQ L E + +IL+ +LQ+ + E L N E E EE K +L + E +
Sbjct: 273 -QVVDLLQQELTAAEQRNQILSQQLQQMEA---EHNTLRNTVETEREESKILLEKMELEV 328
Query: 448 YENK-QFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTEL 506
E K F + EE+ L+ + + +LE + +A+ EQ + E+++ + +
Sbjct: 329 AERKLSFHNLQEEM----HHLLEQFEQAGQAQAELESRYSAL---EQKHKAEMEEKTSHI 381
Query: 507 ENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIEN-- 564
+ + EL S C+ L +N +L Q+ ++ ++ + + + +Q+ + + Q N
Sbjct: 382 LSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRL 441
Query: 565 -LQETETQLRNELEYVREELKQK-RDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQEN 622
LQ+ ET + V E Q +E L K N + + + +EEL+ EN
Sbjct: 442 PLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAEN 501
Query: 623 KALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEEN----- 677
+ L + T Q E E+ + K + +++ + S+++
Sbjct: 502 EKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSV 561
Query: 678 -LLEEVEKAKVIADEAVKLQKEIDKRCQHKIAE----------------MVALMEKHKHQ 720
LLE E + IA ++LQ + + H++ + M +E
Sbjct: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQD 621
Query: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVK----KQL-------EI 769
+ + E S + K + + R S EI L++ EL S K K L +
Sbjct: 622 FPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC 681
Query: 770 EREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWK-LDSKAVPSQTVSRNFTSVD 828
++E E+LK + E E K Q EIY K LD KA +++
Sbjct: 682 HQDELERLKSQILE-----LELNFHKAQ-------EIYEKNLDEKAKEISNLNQLIEEFK 729
Query: 829 HGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEF 888
+ + S + K ++ T + +++Q L + + E++++R++ +E
Sbjct: 730 KNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQ---LEMNLAEAERQRRLDYES 786
Query: 889 DINSDSSETTDLLSMVSEEET 909
D+ T + S+ E ++
Sbjct: 787 QTAHDNLLTEQIHSLSIEAKS 807
Score = 93.6 bits (231), Expect = 8e-19
Identities = 158/784 (20%), Positives = 338/784 (43%), Gaps = 105/784 (13%)
Query: 122 STEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRH 181
S +++L+ KES++ E + + ++EL ++ +S K E + ++ L+++
Sbjct: 835 SLQSQLQNKESEVLEGAERVRHISSKVEEL---SQALSQKELEITKMDQLLLEKKRDVET 891
Query: 182 LCNLLKETCARSAE----KTKKYEYEREETRQVYMDLNNNIEKM--ITAFEELRVQAENS 235
L ++E + E T+K EE + +++ E++ ++ EE + +
Sbjct: 892 LQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEE 951
Query: 236 RLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDK 295
E+ LK++Y+++ Q K+E+ + + LL + +++ K++ +E +
Sbjct: 952 DNEVSSGLKQNYDEMSPAGQISKEEL---QHEFDLLKKENEQRKRKLQAALINRKELLQR 1008
Query: 296 VNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQL 355
V++LEE+ + K+ I E+E+ K + + S + ++++I K Q
Sbjct: 1009 VSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLK---QT 1065
Query: 356 TEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKK 415
EKE +++ K +F+ L++ Q L+ +Q+ +L E+ +
Sbjct: 1066 ISEKEVELQHIRKDLEEKLAAEEQFQA-------LVKQMNQTLQDKTNQIDLLQAEISEN 1118
Query: 416 SSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQ----ELIGLL 471
+ ++++ +T+N + + V KET++ I+ G+ + EL +
Sbjct: 1119 QAIIQKL--ITSNTDAS--DGDSVALVKETVV--------ISPPCTGSSEHWKPELEEKI 1166
Query: 472 QAREKEVHDLEIQLTAITTSEQYYSKEVKD----LKTELENEKLKNTELTSHCNKLSLEN 527
A EKE L+ +L TS + K+ ++ L+ EL+ +K L ++ S EN
Sbjct: 1167 LALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKEN 1226
Query: 528 KEL----------TQETSDMTLELKNQQEDINNNKKQEERMLKQIE-------------- 563
+ + +E+ D L +QQE ++ EE + K E
Sbjct: 1227 ENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCP 1286
Query: 564 ----------------NLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607
++ + + QL+ E+E + EL+ K +L K E L++Q
Sbjct: 1287 DWPSHSEDASALQGGTSVAQIKAQLK-EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQ 1345
Query: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKE 667
+ + IE L+ + + + ++L ++++ LE L + K E+ K+
Sbjct: 1346 INKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE-HLRELQPKLDELQKLISKK 1404
Query: 668 IEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKI--- 724
ED L E+ I E ++ + I + H EM A ++H + ++
Sbjct: 1405 EEDVSYLSGQLSEKEAALTKIQTEIIEQEDLI--KALHTQLEMQA--KEHDERIKQLQVE 1460
Query: 725 ---IEERDSELG-LYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKL-KR 779
++++ E+G ++K+Q Q L+A+L LK E S++++L + R E+L K
Sbjct: 1461 LCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALK-ENKSLQEELSLARGTIERLTKS 1519
Query: 780 EAKENTATLKEKKDKKTQTFLL-----ETPEIYWKLDSKAVPSQTVSRNFTSVD---HGI 831
A + + K+K T L E ++ ++D + +Q++S + S+ G+
Sbjct: 1520 LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL 1579
Query: 832 SKDK 835
++DK
Sbjct: 1580 TEDK 1583
Score = 89.0 bits (219), Expect = 2e-17
Identities = 160/795 (20%), Positives = 334/795 (42%), Gaps = 136/795 (17%)
Query: 97 ENSEGLSRVYSKLYKEAEKIKKWKVSTEAELR---QKESKLQENRKIIEAQRKAIQE--L 151
EN + + + ++L + + IKK + +A+L + S LQ +R I + ++E L
Sbjct: 2430 ENKKAVDKT-NQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHL 2488
Query: 152 QFGNEKVSLKLEEGIQENKDLIKENNATR-HLCNLLKETCARSAEKTKKYE--------- 201
EK L ++E EN L +E R H+ +L E AE + E
Sbjct: 2489 SIILEKDQL-IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIK 2547
Query: 202 -YEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKE 260
++++ +V + N +E EE ++E E + L+ + +Q +Q+ KE
Sbjct: 2548 DSQQKQLLEVQLQQNKELENKYAKLEEKLKESE----EANEDLRRSFNALQEEKQDLSKE 2603
Query: 261 INDKEKQVSLLLIQITE----------------KENKMKDLTFLLEESRDKVNQLEEKTK 304
I + +S L Q+T KE ++ L+ L S+ ++ +LEE+
Sbjct: 2604 IESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELV 2663
Query: 305 -LQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQM 363
+Q E K+ E + L KEL+ + + + EE + + + ++ E+K +
Sbjct: 2664 CVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEM-EQKLLMV 2722
Query: 364 EESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT 423
+ NK A + F ++ SL+ + + D+LK +K + L+E+
Sbjct: 2723 TKENKGLTAQ---IQSFGRSMSSLQN----SRDHANEELDELK------RKYDASLKELA 2769
Query: 424 KLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEI 483
+L KE L ++ ET N E L+ Q+L+ ++++++ L
Sbjct: 2770 QL---KEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL----SKDEQLLHLSS 2822
Query: 484 QLTAITTSEQYYSKEVKDLKTELEN-----EKLKNTELTSHCNKLSLENKELTQ-ETSDM 537
QL Q +SK + L+ E ++ EK + +E E K+ + + S
Sbjct: 2823 QLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSE----------EGKQRSAAQPSTS 2872
Query: 538 TLELKNQQEDINNNKKQEERMLKQIENLQETETQLR---NELEYVREELKQKRDEVKC-K 593
E+++ ++ +++ + +R+LK+++NLQ+ Q+ EL ++ +L++ +D+ K +
Sbjct: 2873 PAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQ 2932
Query: 594 LDKSEENCNNLRKQVENKNKYIEELQQE--NKALKKKGTAESKQLNVYEIKVNKLELELE 651
+ + E NL Q E +E+ E + +K++ + + L EL
Sbjct: 2933 IMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELR 2992
Query: 652 SAKQKFGEITDTYQKEIEDKKIS----EENLLEEVEKAKVIADEAVKLQKEIDKRCQHKI 707
S+ + + YQ++ + + +NL+ E E + ++++K + + R Q
Sbjct: 2993 SSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLN 3052
Query: 708 AEMVALMEK------------------HKHQYD-----KIIEERDSEL------------ 732
+ L+E+ +H D ++E++ EL
Sbjct: 3053 SNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPG 3112
Query: 733 ------GLYKSKEQEQ----SSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAK 782
G+++ + E+ + + +L N + E+ ++K LE ER++ R A
Sbjct: 3113 APQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQ-----RVAA 3167
Query: 783 ENTATLKEKKDKKTQ 797
EN ++ E++ ++ +
Sbjct: 3168 ENALSVAEEQIRRLE 3182
Score = 88.2 bits (217), Expect = 3e-17
Identities = 173/861 (20%), Positives = 376/861 (43%), Gaps = 109/861 (12%)
Query: 88 QEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKA 147
++ L+ E S+ L+R+ + ++ A + V E ++ +EN I + +K
Sbjct: 424 EDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT----QAVTEEN---IASLQKR 476
Query: 148 IQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREET 207
+ EL+ NEK +L L E ++L EN LL+ + + E +RE +
Sbjct: 477 VVELE--NEKGALLLSS--IELEELKAENEKLSSQITLLEA-------QNRTGEADREVS 525
Query: 208 RQVYMDLNNNIEKMITAFEELRVQAENSRLEMH-------FKLKEDYEKIQHLEQEYKKE 260
+D+ N ++ +A E + EN+ + H ++KE E+I L+ + + +
Sbjct: 526 EISIVDIAN--KRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGK 583
Query: 261 INDKEKQVSLLLIQITEKENK----MKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEK 316
++ L ++ + E + +K FL + +D E++ L + +Q+ +
Sbjct: 584 RAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTE 643
Query: 317 QHHLTKE---LEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEES------- 366
T E L D V L+ ST++ ++ L A I Q +++ +++
Sbjct: 644 HQSRTSEEISLNDAGVELK---STKQDGDKSLS-AVPDIGQCHQDELERLKSQILELELN 699
Query: 367 -NKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKL 425
+KA+ + + E + +L +L+ ++ + N L+ E + S+++E++ +
Sbjct: 700 FHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMV 759
Query: 426 TNNKEVELEELKKVLGEKET---LLYENK---------QFEKIAEELKGTEQELIGLLQA 473
T + ++++L+ L E E L YE++ Q ++ E K + ++ +
Sbjct: 760 TELR-AQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKI----EV 814
Query: 474 REKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQE 533
+ E+ D+++Q SEQ S ++ L+++L+N++ + E +S + +EL+Q
Sbjct: 815 LQNELDDVQLQF-----SEQ--STLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQA 867
Query: 534 TSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCK 593
S LE+ + + K+ E + + IE + T++ + +L +++ + +
Sbjct: 868 LSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVE 927
Query: 594 LDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESA 653
+ +E N L + E K + +EE + + LK+ S +I +L+ E +
Sbjct: 928 IKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSP---AGQISKEELQHEFDLL 984
Query: 654 KQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVAL 713
K++ + +++++ I+ + LL+ V + + +E L+ E K + L
Sbjct: 985 KKE----NEQRKRKLQAALINRKELLQRVSR---LEEELANLKDESKKE--------IPL 1029
Query: 714 MEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREE 773
E + + ++ E ++ SK QE + L+ +S + EL ++K LE +
Sbjct: 1030 SETERGEVEEDKENKEYSEKCVTSKCQE---IEIYLKQTISEKEVELQHIRKDLEEKLAA 1086
Query: 774 KEKLKREAKENTATLKEKKDK--KTQTFLLETPEIYWKL----------DSKAVPSQTVS 821
+E+ + K+ TL++K ++ Q + E I KL DS A+ +TV
Sbjct: 1087 EEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVV 1146
Query: 822 RN---FTSVDHGISK-DKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRE-NLNIPIE 876
+ S +H + +++ K L L +A T + K Q++E +L ++
Sbjct: 1147 ISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELK 1206
Query: 877 ESKKK-RKMAFEFDINSDSSE 896
+ K ++ +FD S +E
Sbjct: 1207 QQKDDYNRLQEQFDEQSKENE 1227
Score = 81.6 bits (200), Expect = 3e-15
Identities = 171/836 (20%), Positives = 342/836 (40%), Gaps = 100/836 (11%)
Query: 18 SQVSAVKPQTLGGDSTFFKSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKVNFLPVL 77
+Q V P + K TE++ E K L + E I + LQ
Sbjct: 116 AQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELIST---LQAQLTQAQA 172
Query: 78 EQVGNSDCHYQEG--LKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELR-QKESKL 134
EQ S +E +K E E +S + ++L + + +V E + R + + +L
Sbjct: 173 EQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRL 232
Query: 135 QENRKI-IEAQRKAIQELQFGNEKVSLKLEE------GIQENKDLIKEN-----NATRHL 182
E+ + + Q E+Q + KLEE G + DL+++ + L
Sbjct: 233 HEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQIL 292
Query: 183 CNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFK 242
L++ A E EREE++ + +EKM E ++ N + EMH
Sbjct: 293 SQQLQQMEAEHNTLRNTVETEREESKIL-------LEKMELEVAERKLSFHNLQEEMHHL 345
Query: 243 LKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK 302
L E +E+ + E E + S L E+++K + +EE + L+ K
Sbjct: 346 L-EQFEQAGQAQAEL-------ESRYSAL-----EQKHKAE-----MEEKTSHILSLQ-K 386
Query: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
T + ++ +++ Q+ +K L+D +S T + LE+ LQ +K I Q Q
Sbjct: 387 TGQELQSACDALKDQN--SKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQ 444
Query: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQQR---LEKNEDQLKILTMELQKKSSEL 419
E+ + SF E T EE + + Q+R LE + L + ++EL++ +E
Sbjct: 445 QHET---ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAEN 501
Query: 420 EEMT---------KLTNNKEVELEELKKV-LGEKETLLYENKQFEKIAEELKGTEQELIG 469
E+++ T + E+ E+ V + K + E + + +EL
Sbjct: 502 EKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSV 561
Query: 470 LL---QAREKEVHDLEIQLTAITTSEQYY----SKEVKDLKTE----------LENEKLK 512
LL + ++E+ L++QL E + KE+K ++ E LE+
Sbjct: 562 LLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQD 621
Query: 513 NTELTSHCNKLSLENKELT----QETSDMTLELKNQQEDINNNKKQEERMLKQIENLQET 568
+ + + L KE Q + + L + ++ + K+ ++ L + ++ +
Sbjct: 622 FPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQC 681
Query: 569 ETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQ--ENKALK 626
++ELE ++ ++ + + E+N + K++ N N+ IEE ++ +N +
Sbjct: 682 H---QDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSA 738
Query: 627 KKGTAESKQLNVYEIK----VNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEV 682
+E + + ++K V +L +++ + E + + E + + L E++
Sbjct: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQI 798
Query: 683 EKAKVIA-DEAVK---LQKEIDKRCQHKIAEMVALMEKHKHQY---DKIIEERDSELGLY 735
+ A + VK LQ E+D Q + +E L+ + Q + + E +
Sbjct: 799 HSLSIEAKSKDVKIEVLQNELDD-VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHI 857
Query: 736 KSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEK 791
SK +E S + E+E++ + LL K+ +E ++ E+ ++ E + ++ EK
Sbjct: 858 SSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEK 913
Score = 52.0 bits (123), Expect = 3e-06
Identities = 99/433 (22%), Positives = 173/433 (39%), Gaps = 66/433 (15%)
Query: 51 AKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSD---CHYQEGLKDSDLENSEGLSRVYS 107
++T S N +S L+K+N +Q+ + D H L+DS + S+ +
Sbjct: 2786 SETAFSMNSTEENSLSHLEKLN-----QQLLSKDEQLLHLSSQLEDS-YNQVQSFSKAMA 2839
Query: 108 KLYKEAE----KIKKWKVSTEAELRQKESKLQENRKIIEAQ--RKAIQELQFGNEKVSLK 161
L E + +++K++ S E + R S Q + E Q +KA+ LQ +++ LK
Sbjct: 2840 SLQNERDHLWNELEKFRKSEEGKQR---SAAQPSTSPAEVQSLKKAMSSLQNDRDRL-LK 2895
Query: 162 LEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKM 221
+ +Q+ I + H LK +KTK ++ +EE RQ
Sbjct: 2896 ELKNLQQQYLQINQEITELHP---LKAQLQEYQDKTKAFQIMQEELRQ------------ 2940
Query: 222 ITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENK 281
E L Q E +L M E +E+ ++++Y I+DK++Q+S L I E
Sbjct: 2941 ----ENLSWQHELHQLRMEKSSWEIHER--RMKEQYLMAISDKDQQLSHLQNLIRE---- 2990
Query: 282 MKDLTFLLEESRDKVNQLEEKTKLQ-SENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKA 340
L S + L+ + + Q S S + +L E E ++ L S+
Sbjct: 2991 -------LRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQ 3043
Query: 341 LEEDLQIATKTICQLTEEKET---QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQR 397
E +Q QL EEK T Q+ +++++ + + LE+ ++ Q
Sbjct: 3044 KELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAG 3103
Query: 398 -----------LEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETL 446
EKN K EL++ E + N E+ EL+K+L E+
Sbjct: 3104 PLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQ 3163
Query: 447 LYENKQFEKIAEE 459
+ +AEE
Sbjct: 3164 RVAAENALSVAEE 3176
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 133 bits (334), Expect = 9e-31
Identities = 177/812 (21%), Positives = 352/812 (43%), Gaps = 115/812 (14%)
Query: 86 HYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQR 145
H ++ L + DLE +E +++ S + + +++ + + + + E+K+ + R ++EA
Sbjct: 363 HIEQLLAERDLERAE-VAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAAD 421
Query: 146 KAIQEL--QFGNEK-----VSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
+ EL Q EK + ++EE DL + L+++ K
Sbjct: 422 REKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKAD 481
Query: 199 KYEYEREETRQV-------YMDLNNNIEKMITAFEELRVQAENSR----LEMHFKLKEDY 247
K + E E+TR M+L ++ + ELR + E+++ ++M L ++
Sbjct: 482 KLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE- 540
Query: 248 EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEE--KTKL 305
I L+++ + D +++++ L +E + L + +K+++ E K+KL
Sbjct: 541 --ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL 598
Query: 306 QSENLKQS----IEKQHHLT------KELEDIKVSLQRSVSTQKALEEDLQIATKTI-CQ 354
+ N + S + K T + +E++KVS + + T+ A +L+ + +
Sbjct: 599 EHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLD 658
Query: 355 LTEEKETQMEESNKARAAHSF-----------VVTEFETTVCSLEELL-RTEQQRLEKNE 402
E E + + RAAH+ V+ E E ++ ++ L + E Q L + E
Sbjct: 659 YQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEME 718
Query: 403 DQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKG 462
D L L E + K ELE + N + ++ L E L + K + E K
Sbjct: 719 DTLNKL-QEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKS 777
Query: 463 TEQELIGLLQAREKEVHDLEIQLTAIT-----------------TSEQYYSKEVKDLKTE 505
++L L+A EK++ LEI+ A + T+ Q EV +K
Sbjct: 778 EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 837
Query: 506 LENE----KLKNTELTSHC---------------------NKLSLENKELTQETSDMTLE 540
LE E K K E + N LS + ++L + +DM +
Sbjct: 838 LEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAK 897
Query: 541 LKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR---DEVKCKLDKS 597
+ + E K +E++ I + + ++L + +EL+ K +E++ KL K+
Sbjct: 898 FREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA 957
Query: 598 EENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKF 657
EN + L+K +E+ E+ QQE KK E K+L E K++ LE ++E++ +
Sbjct: 958 NENASFLQKSIEDMTVKAEQSQQE---AAKKHEEEKKEL---ERKLSDLEKKMETSHNQC 1011
Query: 658 GEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVK---------LQKEIDKRCQHKIA 708
E+ Y++ + K E +L+ ++K + ++ +K LQ+ + R Q A
Sbjct: 1012 QELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA 1071
Query: 709 EMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLE-IELSNLK--AELLSVKK 765
+ E +++ +E+ L + +Q + L+ L+ ++ +NLK EL K+
Sbjct: 1072 KAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKE 1131
Query: 766 QLEIEREEKEKLKREAKENTATLKEKKDKKTQ 797
L +E ++ E+ ++E + TLK+ +K+Q
Sbjct: 1132 LLTVENQKMEEFRKEIE----TLKQAAAQKSQ 1159
Score = 122 bits (307), Expect = 1e-27
Identities = 181/797 (22%), Positives = 337/797 (42%), Gaps = 160/797 (20%)
Query: 95 DLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQE-NRKIIEAQRKAIQELQF 153
D++ S L + S L ++ E + L++ +E ++K I+A A ++L
Sbjct: 530 DVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK 589
Query: 154 GNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMD 213
NE + KLE +EN D+I L ET S ++ + ++ +
Sbjct: 590 ENESLKSKLEHANKENSDVIA-------LWKSKLETAIASHQQAME---------ELKVS 633
Query: 214 LNNNIEKMITAFEELRVQAENSRLEMHFKLK-----EDYEKIQH------LEQEYKKEIN 262
+ + F EL+ Q E RL+ +++ +D E+ H L + K I
Sbjct: 634 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 693
Query: 263 DKEKQVSLLLIQITEKENK----MKDLTFLLEESRDKVNQLE-------EKTKLQSENLK 311
+KE + + ++ + E++ M+D L+E+ KV +LE E+TK+ +N
Sbjct: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKV-IDNFT 752
Query: 312 QSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARA 371
++ +L+ ++ + S K L + L+ A K I L EK ES+KA
Sbjct: 753 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNA---ESSKA-- 807
Query: 372 AHSFVVTEF---ETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSEL--------E 420
S + E E + +L+E L Q E E +L+IL + + S E E
Sbjct: 808 --SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 865
Query: 421 EMTKLTNNKEV------ELEELKKVLGEKETLLYENKQFE----KIAEELKGTEQELIGL 470
+ KL +E +LE+L++ L + E E + E K E+L+ E++ +
Sbjct: 866 TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKM 925
Query: 471 --------------LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTEL 516
L+ +E++V +L+++LT + + K ++D+ + E + + +
Sbjct: 926 SGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK- 984
Query: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQ--------IENLQET 568
K E KEL ++ SD+ +++ K + ER + ++NLQ+T
Sbjct: 985 -----KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKT 1039
Query: 569 ETQLRNELEYVREE---LKQKRDEVKCKLDKS---------------------------- 597
++L+ REE L Q+ +E++ + DK+
Sbjct: 1040 LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLE 1099
Query: 598 -----------------EENCNNLRKQVENK------NKYIEELQQENKALKKKGTAESK 634
E N N+ + ++K N+ +EE ++E + LK+ +S+
Sbjct: 1100 DTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ 1159
Query: 635 QLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLE-EVEKAKVIAD--- 690
QL+ + + KL EL ++ E+T ++QK E++ + LLE + ++K I D
Sbjct: 1160 QLSALQEENVKLAEELGRSRD---EVT-SHQKLEEERSVLNNQLLEMKKRESKFIKDADE 1215
Query: 691 EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLE 750
E LQK I + E A +EK +++ + E S L+ S Q S + LE
Sbjct: 1216 EKASLQKSISITSA-LLTEKDAELEKLRNEVTVLRGENASAKSLH-SVVQTLESDKVKLE 1273
Query: 751 IELSNLKAELLSVKKQL 767
+++ NL+ +L K+QL
Sbjct: 1274 LKVKNLELQLKENKRQL 1290
Score = 109 bits (273), Expect = 1e-23
Identities = 161/701 (22%), Positives = 305/701 (43%), Gaps = 87/701 (12%)
Query: 97 ENSEGLSRVYSKLYKEAEKIKKWKVST-----EAELRQKE-----SKLQENRKIIE---A 143
E L + SKL K ++ T EAE++ KE +K E K+I+ +
Sbjct: 694 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 753
Query: 144 QRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYE 203
Q KA +E + + EG E K L ++ A L+ ++AE +K
Sbjct: 754 QLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE--IEKNAESSKASSIT 811
Query: 204 RE-ETRQVYM-DLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEI 261
RE + R++ + +L N+ ++ E L + + + E + E+ +Q QE ++
Sbjct: 812 RELQGRELKLTNLQENLSEVSQVKETLEKELQILK-EKFAEASEEAVSVQRSMQETVNKL 870
Query: 262 NDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLT 321
+ KE+Q ++L LE+ R+ + +E K + + E +Q I+ + L
Sbjct: 871 HQKEEQFNMLSSD--------------LEKLRENLADMEAKFREKDEREEQLIKAKEKLE 916
Query: 322 KELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFE 381
++ +I + S + ++L++ + + EE + ++ ++N+ SF+ E
Sbjct: 917 NDIAEIMKMSGDNSSQLTKMNDELRLKERDV----EELQLKLTKANENA---SFLQKSIE 969
Query: 382 TTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELE-ELKKVL 440
E+ ++Q+ +K+E++ K EL++K S+LE+ + ++N+ EL+ ++
Sbjct: 970 DMTVKAEQ---SQQEAAKKHEEEKK----ELERKLSDLEKKMETSHNQCQELKARYERAT 1022
Query: 441 GEKETLLYE-----NKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY 495
E +T E K ++LKG +E GLLQ E E+ + A T+E
Sbjct: 1023 SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE-ELRKQADKAKAAQTAED-- 1079
Query: 496 SKEVKDLKTELENEKLKNTELTSHCN-KLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
+ ++ + T+ + E L + E T N KL E L + EL +E + ++
Sbjct: 1080 AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK 1139
Query: 555 EERMLKQIENLQETETQLRNELEYVREE-------LKQKRDEVKCKLDKSEENC---NNL 604
E K+IE L++ Q +L ++EE L + RDEV EE N L
Sbjct: 1140 MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQL 1199
Query: 605 RKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELEL-----ESAKQK-FG 658
+ + ++K+I++ +E +L+K + S L + ++ KL E+ E+A K
Sbjct: 1200 LEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLH 1259
Query: 659 EITDTYQKEIEDKKISEENL---LEEVEKAKVIADEAVKLQKEIDKRCQHK---IAEMVA 712
+ T + + ++ +NL L+E ++ + Q + D+R Q V
Sbjct: 1260 SVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI 1319
Query: 713 LMEKHKHQYDKIIEERDSELGL---------YKSKEQEQSS 744
+ + K+Q K+ E SE L Y S +QE+ S
Sbjct: 1320 VDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQS 1360
Score = 65.1 bits (157), Expect = 3e-10
Identities = 81/382 (21%), Positives = 164/382 (42%), Gaps = 55/382 (14%)
Query: 486 TAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQ 545
TA+ + + + ++ L E + E+ + + TSH ++ E LEL+ +
Sbjct: 351 TALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKM 410
Query: 546 EDIN--------------NNKKQEERMLKQI------ENLQETETQLRNELEYVR-EELK 584
+ + N ++E+R ++ + E++ + + + + +LE+ R +EL+
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELE 470
Query: 585 QKRDEVKCKLDKSEENCNNLR-KQVENKNKYIE-------------ELQQENKALKKKGT 630
Q K K DK + + R V K++ +E EL++ ++ K G
Sbjct: 471 QSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGD 530
Query: 631 AESKQLNVYEIK--VNKLEL-------ELESAKQKFGEITDTYQKEIEDKKISEENLLEE 681
+ + EI KLE+ E+ S K+ FG +T+QKEI+ + E L +E
Sbjct: 531 VDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKE 590
Query: 682 VEKAKVIADEAVKLQKEIDKRCQHKIAEMVA----LMEKHKHQYDKIIEERDSELGLYKS 737
E K + A K ++ + K+ +A ME+ K + K + +E K+
Sbjct: 591 NESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKT 650
Query: 738 KEQEQSSLRASLEIELSNLK----AELLSVKKQLEIEREEKEKLKREAKENTATLKEKKD 793
+ ++ +R + E+ NL+ +E + K++E R + K+ +E + + ++ K D
Sbjct: 651 QIEK---MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD 707
Query: 794 KKTQTFLLETPEIYWKLDSKAV 815
K L+E + KL +
Sbjct: 708 KAEDQHLVEMEDTLNKLQEAEI 729
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 132 bits (331), Expect = 2e-30
Identities = 200/926 (21%), Positives = 388/926 (41%), Gaps = 151/926 (16%)
Query: 115 KIKKWKVSTEAELRQKESKL-----------QENRKIIEAQRKAIQELQFGNEKVS---- 159
K++K K +TE +++ ++ +E + + EA ++A+ +LQ +KV+
Sbjct: 965 KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSK 1024
Query: 160 --LKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNN 217
+KLE+ + + + +++ R K +K E + + T++ MDL N+
Sbjct: 1025 SKVKLEQQVDDLEGSLEQEKKVRMDLERAK----------RKLEGDLKLTQESIMDLEND 1074
Query: 218 ---IEKMITAFEELRVQAENSRLE--------MHFKLKEDYEKIQHLEQEYKKEINDKEK 266
+E+ + +E + +NS++E + KLKE+ +I+ LE+E + E + K
Sbjct: 1075 KLQLEEKLKK-KEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAK 1133
Query: 267 QVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELED 326
E DL+ LEE +++ + T +Q E K+ + + ++LE+
Sbjct: 1134 -----------VEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1182
Query: 327 IKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCS 386
+ + + + + D ++ +L E+ + K S E + +
Sbjct: 1183 ATLQHEATAAALRKKHAD------SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1236
Query: 387 LEELLRTEQQRLEK----NEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGE 442
+E++++ + LEK EDQ ++L++ L + T + E EL + L E
Sbjct: 1237 MEQIIKA-KANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEE 1295
Query: 443 KETLLYE--------NKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY 494
KE L+ + +Q E + +L+ + L A + HD ++ EQY
Sbjct: 1296 KEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDL------LREQY 1349
Query: 495 YSKEVKDLKTELENEKLK-NTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKK 553
+E + K EL+ K N+E+ K + + T+E + +L + +D ++
Sbjct: 1350 --EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA---EE 1404
Query: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNK 613
E + + +L++T+ +L+NE+E + ++ ++ + LDK + N + + E K K
Sbjct: 1405 AVEAVNAKCSSLEKTKHRLQNEIEDLMVDV-ERSNAAAAALDKKQRNFDKI--LAEWKQK 1461
Query: 614 YIE---ELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIED 670
Y E EL+ K + T K N YE + LE K EI+D ++ E
Sbjct: 1462 YEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEG 1521
Query: 671 KKISEENLLEEVEKAKVIADEAVKLQ---KEIDKRCQH---KIAEMVALMEKHKHQYDKI 724
K E LE+V K + E ++LQ +E + +H KI + K + ++
Sbjct: 1522 GKNVHE--LEKVRKQLEV--EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERK 1577
Query: 725 IEERDSELGLYKSKEQE-QSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
+ E+D E+ K Q SL+ SL+ E + + E+L VKK++E + E E ++
Sbjct: 1578 LAEKDEEMEQAKRNHQRVVDSLQTSLDAE-TRSRNEVLRVKKKMEGDLNEME-IQLSHAN 1635
Query: 784 NTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSA 843
A +K+ K Q+ L +T +LD + + N V+
Sbjct: 1636 RMAAEAQKQVKSLQSLLKDT---QIQLDDAVRANDDLKENIAIVER-------------R 1679
Query: 844 KNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDS------SET 897
N L L E L +E++++ RK+A + I + S+
Sbjct: 1680 NNLLQAEL-----------------EELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1722
Query: 898 TDLLSMVSEEETLKTLYRNNNPPASHLCVKTPKKAPSSLTTPGSTLKFGAIRKMREDRWA 957
T L++ + E+ T ++ A C +KA ++T K +D A
Sbjct: 1723 TSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAIT---DAAMMAEELKKEQDTSA 1779
Query: 958 VIAKM---------DRKKKLKEAEKL 974
+ +M D + +L EAE++
Sbjct: 1780 HLERMKKNMEQTIKDLQHRLDEAEQI 1805
Score = 126 bits (316), Expect = 1e-28
Identities = 170/753 (22%), Positives = 325/753 (43%), Gaps = 73/753 (9%)
Query: 91 LKDSDLENSEGLSRVYSKLYKEAEKIKKWKV---STEAELRQKESKLQENRKIIEAQRKA 147
L++ L+ E L + + ++ KI+ +V + +L++ +++++E + +EA+R A
Sbjct: 1071 LENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTA 1130
Query: 148 IQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCAR-------SAEKTKKY 200
+++ +S +LEE I E L + AT + K+ A E T ++
Sbjct: 1131 RAKVEKLRSDLSRELEE-ISER--LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQH 1187
Query: 201 EYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKE---DYEKIQHLEQEY 257
E R+ + D + + I + ++ + E + E +L + + E+I +
Sbjct: 1188 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1247
Query: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTF----LLEESRDKVNQLEEKTKLQSENLKQS 313
+K E Q + +++ E + + D T L E+ + QLEEK L S+ +
Sbjct: 1248 EKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGK 1307
Query: 314 IEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAH 373
+ T+++ED+K L+ + AL LQ A + C L E Q EE +A+A
Sbjct: 1308 LS----YTQQMEDLKRQLEEEGKAKNALAHALQSA-RHDCDLLRE---QYEEETEAKAEL 1359
Query: 374 SFVVTEFETTVCSLEELLRTEQ-QRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVE 432
V+++ + V T+ QR E+ E+ K L LQ + EE + N K
Sbjct: 1360 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ----DAEEAVEAVNAKCSS 1415
Query: 433 LEELK-KVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTS 491
LE+ K ++ E E L+ + ++ A L ++ +L +++ + + +L
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSEL------ 1469
Query: 492 EQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLEL----KNQQED 547
+ KE + L TEL K E H ENK L +E SD+T +L KN E
Sbjct: 1470 -ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHEL 1528
Query: 548 INNNKKQEERMLKQIENLQETETQLRNE---LEYVREELKQKRDEVKCKLDKSEENCNNL 604
K+ E L+ L+E E L +E + + E Q + E++ KL + +E
Sbjct: 1529 EKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQA 1588
Query: 605 RKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTY 664
++ N + ++ LQ A + + E +N++E++L A + E
Sbjct: 1589 KR---NHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEA---- 1641
Query: 665 QKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKI 724
QK+++ S ++LL++ + + D+AV R + E +A++E+ +
Sbjct: 1642 QKQVK----SLQSLLKDTQ---IQLDDAV--------RANDDLKENIAIVERRNNLLQAE 1686
Query: 725 IEERDS--ELGLYKSKEQEQSSLRASLEIE-LSNLKAELLSVKKQLEIEREEKEKLKREA 781
+EE + E K EQ + S ++ L + L++ KK++E + + + EA
Sbjct: 1687 LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEA 1746
Query: 782 KENTATLKEKKDKKTQTFLLETPEIYWKLDSKA 814
+ +EK K + E+ + D+ A
Sbjct: 1747 VQECRNAEEKAKKAITDAAMMAEELKKEQDTSA 1779
Score = 124 bits (310), Expect = 6e-28
Identities = 201/953 (21%), Positives = 391/953 (41%), Gaps = 201/953 (21%)
Query: 39 NKCTE-----DDFEFPFAKTNLSKNG-----ENIDSDPA-LQKVNFLPVLEQVGNSDCHY 87
++C+E DD E AK K+ +N+ + A L ++ E+ + H
Sbjct: 947 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH- 1005
Query: 88 QEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKA 147
Q+ L D +E + S SK+ E +++ + S E E ++ L+ ++ +E K
Sbjct: 1006 QQALDDLQVEEDKVNSLSKSKVKLE-QQVDDLEGSLEQE-KKVRMDLERAKRKLEGDLKL 1063
Query: 148 IQELQFGNEKVSLKLEEGI--------QENKDLIKENNATRHLCNLLKETCARSAEKTKK 199
QE E L+LEE + Q+N + E L LKE AR E ++
Sbjct: 1064 TQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEE 1123
Query: 200 YEYERE---ETRQVYMDLNNNIEKMITAFEEL----RVQAE-NSRLEMHF-KLKEDYEK- 249
E ER + ++ DL+ +E++ EE VQ E N + E F K++ D E+
Sbjct: 1124 LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA 1183
Query: 250 -IQHLE-----------------------QEYKKEINDKEKQVSLLLIQITEK------- 278
+QH Q K+++ ++ + L L +T
Sbjct: 1184 TLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKA 1243
Query: 279 -----------ENKMKDLTFLLEESRDKVNQLE-EKTKLQSEN--LKQSIEKQHHL---- 320
E++ + LEE++ +N ++ KLQ+EN L + +E++ L
Sbjct: 1244 KANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQL 1303
Query: 321 -------TKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAH 373
T+++ED+K L+ + AL LQ A C L E Q EE +A+A
Sbjct: 1304 TRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHD-CDLLRE---QYEEETEAKAEL 1359
Query: 374 SFVVTEFETTVCSLEELLRTEQ-QRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVE 432
V+++ + V T+ QR E+ E+ K L LQ + EE + N K
Sbjct: 1360 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ----DAEEAVEAVNAKCSS 1415
Query: 433 LEELK-KVLGEKETLLYE--------------NKQFEKIAEELKGTEQELIGLLQAREKE 477
LE+ K ++ E E L+ + + F+KI E K +E L++ +KE
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1475
Query: 478 VHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNK--------------- 522
L +L + + + + ++ K E +N + + ++LT +
Sbjct: 1476 ARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL 1535
Query: 523 ---------------LSLENKE---------LTQETSDMTLELKNQQEDINNNKKQEERM 558
SLE++E Q +++ +L + E++ K+ +R+
Sbjct: 1536 EVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRV 1595
Query: 559 LKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEEL 618
+ ++ + ET+ RNE+ V+++++ +E++ +L + +KQV++ +++
Sbjct: 1596 VDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1655
Query: 619 QQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENL 678
Q + + + + + E + N L+ ELE E+ ++ +K++E+ L
Sbjct: 1656 QIQLDDAVRANDDLKENIAIVERRNNLLQAELE-------ELRAVVEQTERSRKLAEQEL 1708
Query: 679 LEEVEKAKVI------------------------ADEAVKLQKEIDKRCQHKIAEMVALM 714
+E E+ +++ +EAV+ + +++ + I + +
Sbjct: 1709 IETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMA 1768
Query: 715 EKHKHQYD---------KIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKK 765
E+ K + D K +E+ +L ++ E EQ +L+ + +L L+A + ++
Sbjct: 1769 EELKKEQDTSAHLERMKKNMEQTIKDL-QHRLDEAEQIALKGGKK-QLQKLEARVRELEG 1826
Query: 766 QLEIEREE-----KEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSK 813
+LE E++ K K E + T + ++DKK LL ++ KL K
Sbjct: 1827 ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKN---LLRLQDLVDKLQLK 1876
Score = 107 bits (268), Expect = 4e-23
Identities = 163/692 (23%), Positives = 291/692 (42%), Gaps = 84/692 (12%)
Query: 170 KDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELR 229
K L+K + + + KE R E +K E R+E EKM++ +E
Sbjct: 839 KPLLKSAETEKEMATM-KEEFGRIKETLEKSEARRKELE----------EKMVSLLQE-- 885
Query: 230 VQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLL 289
K D + EQ+ +ND E++ L+ + E K+K++ L
Sbjct: 886 --------------KNDLQLQVQAEQD---NLNDAEERCDQLIKNKIQLEAKVKEMNERL 928
Query: 290 EESRDKVNQLE-EKTKLQSE--NLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQ 346
E+ + +L +K KL+ E LK+ I+ ++E K + + V K L E++
Sbjct: 929 EDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV---KNLTEEMA 985
Query: 347 IATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL-LRTEQQRLEKNEDQL 405
+ I +LT+EK+ E +A V E + S ++ L + LE + +Q
Sbjct: 986 GLDEIIAKLTKEKKALQEAHQ--QALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQE 1043
Query: 406 KILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQ 465
K + M+L++ +LE KLT ++LE K L EK + K+F+ + K ++
Sbjct: 1044 KKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK----LKKKEFDINQQNSKIEDE 1099
Query: 466 ELIGL-LQAREKE----VHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHC 520
+++ L LQ + KE + +LE +L A T+ K DL ELE E + E
Sbjct: 1100 QVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELE-EISERLEEAGGA 1158
Query: 521 NKLSLE-NKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYV 579
+ +E NK+ E M +L ++ + + K +++ E Q+ N L+ V
Sbjct: 1159 TSVQIEMNKKREAEFQKMRRDL--EEATLQHEATAAALRKKHADSVAELGEQIDN-LQRV 1215
Query: 580 REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVY 639
+++L++++ E K +LD N + K N K L+ + + K + LN +
Sbjct: 1216 KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDF 1275
Query: 640 EIKVNKLELE-------LESAKQKFGEITD---TYQKEIEDKKISEENLLEEVEKAKVIA 689
+ KL+ E LE + ++T +Y +++ED K LEE KAK
Sbjct: 1276 TTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLK----RQLEEEGKAKNAL 1331
Query: 690 DEAVK--------LQKEIDKRCQHKIAEMVALMEK-------HKHQYDKIIEERDSELGL 734
A++ L+++ ++ + K AE+ ++ K + +Y+ +R EL
Sbjct: 1332 AHALQSARHDCDLLREQYEEETEAK-AELQRVLSKANSEVAQWRTKYETDAIQRTEELEE 1390
Query: 735 YKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDK 794
K K+ Q A +E N K L K E + E A +KK +
Sbjct: 1391 AK-KKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1449
Query: 795 KTQTFLLETPEIYWKLDSKAVPSQTVSRNFTS 826
L E + Y + S+ SQ +R+ ++
Sbjct: 1450 NFDKILAEWKQKYEESQSELESSQKEARSLST 1481
Score = 104 bits (260), Expect = 4e-22
Identities = 130/626 (20%), Positives = 270/626 (43%), Gaps = 57/626 (9%)
Query: 79 QVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENR 138
Q DC + + E L RV SK E + +W+ E + Q+ +L+E +
Sbjct: 1336 QSARHDCDLLREQYEEETEAKAELQRVLSKANSE---VAQWRTKYETDAIQRTEELEEAK 1392
Query: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
K + AQR +Q+ + E V+ K +++ K + +N + ++ + A +A K
Sbjct: 1393 KKL-AQR--LQDAEEAVEAVNAKCSS-LEKTKHRL-QNEIEDLMVDVERSNAAAAALDKK 1447
Query: 199 KYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEK-IQHLEQEY 257
+ +++ + + E+ + E + +A + E+ FKLK YE+ ++HLE +
Sbjct: 1448 QRNFDK-----ILAEWKQKYEESQSELESSQKEARSLSTEL-FKLKNAYEESLEHLET-F 1500
Query: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK-LQSENLKQSIEK 316
K+E + ++++S DLT L E V++LE+ K L+ E L+
Sbjct: 1501 KRENKNLQEEIS--------------DLTEQLGEGGKNVHELEKVRKQLEVEKLE----- 1541
Query: 317 QHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFV 376
L LE+ + SL+ + + I + EK+ +ME+ A+ H V
Sbjct: 1542 ---LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ---AKRNHQRV 1595
Query: 377 VTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEEL 436
V +T++ E R E R++K + +L + +L ++ + +++ L
Sbjct: 1596 VDSLQTSL-DAETRSRNEVLRVKKKMEG------DLNEMEIQLSHANRMAAEAQKQVKSL 1648
Query: 437 KKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYS 496
+ +L + + L + + +E + LLQA E+ +L + S +
Sbjct: 1649 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA---ELEELRAVVEQTERSRKLAE 1705
Query: 497 KEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEE 556
+E+ + ++ +NT L + K+ + +L E + E +N +E
Sbjct: 1706 QELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAA 1765
Query: 557 RMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC-NNLRKQVENKNKYI 615
M ++++ Q+T L E +++ ++Q +++ +LD++E+ +KQ++ +
Sbjct: 1766 MMAEELKKEQDTSAHL----ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARV 1821
Query: 616 EELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISE 675
EL+ E +A +K+ K + E ++ +L + E K+ + D K K +
Sbjct: 1822 RELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYK 1881
Query: 676 ENLLEEVEKAKVIADEAVKLQKEIDK 701
E E+A + K+Q E+D+
Sbjct: 1882 RQAEEAEEQANTNLSKFRKVQHELDE 1907
Score = 92.0 bits (227), Expect = 2e-18
Identities = 90/448 (20%), Positives = 216/448 (48%), Gaps = 41/448 (9%)
Query: 389 ELLRTEQQRLEKNEDQLKILTMELQ-----------KKSSELEEMTKLTNNKEVELEELK 437
+L+R E +++ + D L ++ ++ K +++ + K E E+ +K
Sbjct: 797 QLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAET-EKEMATMK 855
Query: 438 KVLGE-KETLLYENKQFEKIAEELKGTEQELIGL---LQAREKEVHDLEIQLTAITTSEQ 493
+ G KETL + +++ E++ QE L +QA + ++D E + + ++
Sbjct: 856 EEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKI 915
Query: 494 YYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKK 553
+VK++ LE+E+ N ELT+ KL E EL ++ D+ L L +++ + +
Sbjct: 916 QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN 975
Query: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLD----------KSEENCNN 603
+ + + +++ L E +L E + ++E +Q D+++ + D K E+ ++
Sbjct: 976 KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDD 1035
Query: 604 LRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDT 663
L +E + K +L++ + K +G + Q ++ +++ +KL+LE + K++F +
Sbjct: 1036 LEGSLEQEKKVRMDLERAKR--KLEGDLKLTQESIMDLENDKLQLEEKLKKKEFD--INQ 1091
Query: 664 YQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDK 723
+IED+++ L +++++ + +E ++ + E ++ + K+ ++ + + + + +
Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEE-LEEELEAERTARAKVEKLRSDLSRELEEISE 1150
Query: 724 IIEERDS----ELGLYKSKEQEQSSLRASLEIELSNLKAELLSV-KKQLEIEREEKEKLK 778
+EE ++ + K +E E +R LE +A ++ KK + E E++
Sbjct: 1151 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQI- 1209
Query: 779 REAKENTATLKEKKDKKTQTFLLETPEI 806
+N +K+K +K+ F LE ++
Sbjct: 1210 ----DNLQRVKQKLEKEKSEFKLELDDV 1233
Score = 88.6 bits (218), Expect = 3e-17
Identities = 104/517 (20%), Positives = 217/517 (41%), Gaps = 32/517 (6%)
Query: 95 DLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFG 154
D+E S + K + +KI L + + K +E++ +E+ +K + L
Sbjct: 1433 DVERSNAAAAALDKKQRNFDKI----------LAEWKQKYEESQSELESSQKEARSLSTE 1482
Query: 155 NEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDL 214
K+ EE ++ + +EN + + L E + + E R++ ++L
Sbjct: 1483 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLEL 1542
Query: 215 NNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQ 274
+ +E+ + E + ++LE + E K+ ++E ++ + ++ V L
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTS 1602
Query: 275 ITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRS 334
+ + ++ + ++ +N++E + + ++ ++ L L+D ++ L +
Sbjct: 1603 LDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1662
Query: 335 VSTQKALEEDLQIATKTICQLT---EEKETQMEESNKARAAHSFVVTEFETTVCSLEELL 391
V L+E++ I + L EE +E++ ++R + E V +LL
Sbjct: 1663 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV----QLL 1718
Query: 392 RTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENK 451
++ L +Q K + +L + SE+EE + N E E+ KK + + + E K
Sbjct: 1719 HSQNTSLI---NQKKKMESDLTQLQSEVEEAVQECRNAE---EKAKKAITDAAMMAEELK 1772
Query: 452 QFEKIA---EELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELEN 508
+ + + E +K ++ I LQ R E +I L Q V++L+ ELE
Sbjct: 1773 KEQDTSAHLERMKKNMEQTIKDLQHRLDEAE--QIALKGGKKQLQKLEARVRELEGELEA 1830
Query: 509 EKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQET 568
E+ +N E K KELT +T + L Q+ ++ + + + +Q E +E
Sbjct: 1831 EQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1890
Query: 569 ETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR 605
++ V+ EL DE + + D +E N LR
Sbjct: 1891 ANTNLSKFRKVQHEL----DEAEERADIAESQVNKLR 1923
Score = 40.4 bits (93), Expect = 0.008
Identities = 42/222 (18%), Positives = 98/222 (44%), Gaps = 16/222 (7%)
Query: 96 LENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGN 155
+E SE + ++S+ + KK + + E +QE R E +KAI +
Sbjct: 1709 IETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMA 1768
Query: 156 EKVSLKLEEGIQENKDLIKEN-----NATRHLCNLLKETCARSAEK--------TKKYEY 202
E+ LK E+ + + +K+N +H + ++ + +K ++ E
Sbjct: 1769 EE--LKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEG 1826
Query: 203 EREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN 262
E E ++ + + K +EL Q E + + +L++ +K+Q + YK++
Sbjct: 1827 ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNL-LRLQDLVDKLQLKVKAYKRQAE 1885
Query: 263 DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
+ E+Q + L + + ++++ + + + +VN+L K++
Sbjct: 1886 EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 131 bits (330), Expect = 3e-30
Identities = 184/816 (22%), Positives = 351/816 (43%), Gaps = 72/816 (8%)
Query: 86 HYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQR 145
H QE L+ + ++S+ LS +L + ++ K K E +++L E+
Sbjct: 2032 HLQEKLQSLE-KDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS 2090
Query: 146 KAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYERE 205
KA++ + +L+L +E L + R ++ AEK K+ E E +
Sbjct: 2091 KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
Query: 206 ETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKE 265
+ +L ++ E + + AENS+ E+ LK E++ + ++ ++
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEVE-TLKTQIEEMARSLKVFELDLVTLR 2209
Query: 266 KQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELE 325
+ L QI EK+ ++ +L LL + + + E+ E K ++E + KEL
Sbjct: 2210 SEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELN 2269
Query: 326 DIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEES-NKARAAHSFVVTEFETTV 384
+ +L KA E+ L E+E Q+ S K RA + + + +
Sbjct: 2270 EAVAALCGDQEIMKATEQSLDPPI--------EEEHQLRNSIEKLRAR---LEADEKKQL 2318
Query: 385 CSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKE 444
C L Q+L+++E +L ++ ELE + +E E K GE E
Sbjct: 2319 CVL--------QQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSK---GEVE 2367
Query: 445 TLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKT 504
TL + E + + L+G E +++ + +E ++L+ + I+ E + +++
Sbjct: 2368 TL---KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE-IINSSFENILQ 2423
Query: 505 ELENEKLKNTELTSHCNK-LSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE 563
E E EK++ E +S + L + KEL + + L N QE K +E+ + Q+E
Sbjct: 2424 EKEQEKVQMKEKSSTAMEMLQTQLKELNERVA----ALHNDQEAC---KAKEQNLSSQVE 2476
Query: 564 NLQETETQLRNELEYVREE----------LKQKRDEVKCKLDKSEENCNNLRKQVENKNK 613
L+ + QL L+ + L Q+ ++ K KL+K +E + L+ Q++++ +
Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ 2536
Query: 614 YIEELQQEN--KALKKKGTAESKQLNV-YEIKVNKLELELESAKQKFGEITDTYQKEIED 670
+ +L Q L K+ E + L V E K+ L+ + S + + +Y+ +
Sbjct: 2537 LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENE 2596
Query: 671 KKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDS 730
++++ + + VEK + + +LQ+E+ + Q K AE+ + K++
Sbjct: 2597 LELTKMDKMSFVEKVNKMTAKETELQREMHEMAQ-KTAELQEELSGEKNRLA-------G 2648
Query: 731 ELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKE 790
EL L + + L +E S LK L + K + E++ K++ E E L E
Sbjct: 2649 ELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD---QVEKEGKVREEIAEYQLRLHE 2705
Query: 791 KKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDY-LWTSAKNTLST 849
+KK Q LL+T + Y V QT TS + +S K + L S+K L+
Sbjct: 2706 A-EKKHQALLLDTNKQY------EVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNN 2758
Query: 850 PLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMA 885
L T + + K + +NL + + KK+ + A
Sbjct: 2759 SLKA--TTQILEELKKTKMDNLKY-VNQLKKENERA 2791
Score = 122 bits (306), Expect = 2e-27
Identities = 158/744 (21%), Positives = 318/744 (42%), Gaps = 99/744 (13%)
Query: 114 EKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLI 173
+++K ++ + E +LQ + K ++ Q QELQ EK ++L E
Sbjct: 281 DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIE--------- 331
Query: 174 KENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAE 233
KE + L++ T +Y++ T+ Y L ++K+ R AE
Sbjct: 332 KEKVLNKCRDELVRTTA----------QYDQASTK--YTALEQKLKKLTEDLSCQRQNAE 379
Query: 234 NSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESR 293
++R + K+KE ++ Q ++ +++ + ++T++ + K++ +L+
Sbjct: 380 SARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAEL 439
Query: 294 DKVNQLEEKTKLQSENLKQSI-----------EKQHHLTKELEDIKV--SLQRSVSTQKA 340
DK+ ++++ + E KQ + K++ L + +E++K +L +S S QKA
Sbjct: 440 DKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKA 499
Query: 341 LEE-DLQIATKTICQLTEEKETQMEESNKARAA----------------HSFVVTEFETT 383
E L+ K I Q + + EE + +S + + +
Sbjct: 500 REVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLA 559
Query: 384 VCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEK 443
V LE+ Q L+K E ++ L +L K E + + K+ E EELK+ EK
Sbjct: 560 VADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKE---EK 616
Query: 444 ETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLK 503
+ EK+ +++ ++ L + +++ LE L Y++ V+ L+
Sbjct: 617 TLFSCWKSENEKLLTQMESEKENL-------QSKINHLETCLKTQQIKSHEYNERVRTLE 669
Query: 504 TELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLK--- 560
+ EN ++ L + + S+E + TQ+ + M L+ K + D + K+ E LK
Sbjct: 670 MDRENLSVEIRNLHNVLDSKSVEVE--TQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQ 727
Query: 561 ---QIENLQETETQLRNEL-------EYVREELKQKRDEVKCK---LDKSEENCNNL--- 604
Q+E+L+ L NE+ + + E + RD +K K L +E++ +L
Sbjct: 728 LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAF 787
Query: 605 RKQVENKNKYIE------ELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFG 658
+Q + + + E + + K + + +V+ LE LES KQ
Sbjct: 788 DQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNS 847
Query: 659 EITDTYQKEIEDKKISEENLLE-EVEKAKVIADEAVKLQK--EIDKRCQHKIAEMVALME 715
++ ++ ++ K EENL++ E +A+ + ++ K E Q+ +AE ++ +E
Sbjct: 848 DLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALE 907
Query: 716 KHKHQY----DKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIER 771
+ + DK+ E+ L KS + SL+ L++ L E + + + +
Sbjct: 908 NKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK-ELQLLSETLSLEKKEMSSIISLNK 966
Query: 772 EEKEKLKRE---AKENTATLKEKK 792
E E+L +E KE A+L ++K
Sbjct: 967 REIEELTQENGTLKEINASLNQEK 990
Score = 121 bits (304), Expect = 3e-27
Identities = 172/777 (22%), Positives = 323/777 (41%), Gaps = 119/777 (15%)
Query: 78 EQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKL--Q 135
EQ CH + LK+ + + ++ AE++K S E LR + K+ Q
Sbjct: 496 EQKAREVCHLEAELKN--------IKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ 547
Query: 136 ENRKIIEAQRKAIQELQFG---NEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCAR 192
EN +E + A+ +L+ ++ + K E I++ D + + KE+ A
Sbjct: 548 ENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTE---------KESKAL 598
Query: 193 -SAEKTKKYEYER-EETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKI 250
SA + KK EYE +E + ++ + EK++T E +E L+ E K
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQME-----SEKENLQSKINHLETCLKT 653
Query: 251 QHLEQ-EYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSEN 309
Q ++ EY + + E L ++I N + + +E + +L++K + +
Sbjct: 654 QQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQK 713
Query: 310 LKQSIE----KQHHLTKELEDIKVSLQ---RSVSTQKALEEDLQIATKTICQLTEEKETQ 362
++ IE K LT ++ED++ LQ + + +DL +++ L + K+
Sbjct: 714 HQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDAS 773
Query: 363 M---EESNKARAA--------HSFV-VTEFETTVCSLEELLRTEQQRLEKNEDQLKILTM 410
+ E+ ++ A HSF + + ++ S R E + KN IL
Sbjct: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNS---AILQN 830
Query: 411 ELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEK--IAEELKGTEQELI 468
+ LE ++ ++ + + EEL ++ GE E L + +Q + +AE T Q +
Sbjct: 831 RVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAE----TSQRIS 886
Query: 469 GLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENK 528
L + + + L+A+ E KE++ L ++E E+ + EL + L K
Sbjct: 887 KLQEDTSAHQNVVAETLSALENKE----KELQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
Query: 529 ELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRD 588
EL + ++LE K I+ NK++ E + ++ L+E L E + L QK +
Sbjct: 943 ELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQE----KMNLIQKSE 998
Query: 589 EVKCKLDKSEENCNNLRKQV------------ENKNKYIEELQQENKALKKKGTAESKQL 636
+D+ E++ + L Q E N Y E+L Q+ KA ++K + L
Sbjct: 999 SFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY-EDLSQKYKAAQEKNSKLECLL 1057
Query: 637 NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAK---------- 686
N + ELE K+ F + + ++ + +NL+ E+E +
Sbjct: 1058 NECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDN 1117
Query: 687 ----------------VIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQ------YDKI 724
+ +E K+QKE++ Q M + KH+ Q
Sbjct: 1118 QNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNS 1177
Query: 725 IEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVK-----KQLEIEREEKEK 776
++ER+SE K Q ++ EI L + A+L+ ++ K+L+++ EKEK
Sbjct: 1178 VKERESERNQCNFKPQMDLEVK---EISLDSYNAQLVQLEAMLRNKELKLQESEKEK 1231
Score = 121 bits (304), Expect = 3e-27
Identities = 151/741 (20%), Positives = 330/741 (44%), Gaps = 50/741 (6%)
Query: 54 NLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEA 113
+L EN++ + + + N V+ NS E LK E ++R +
Sbjct: 2151 SLKDKVENLERELQMSEENQELVILDAENSKAEV-ETLKTQ----IEEMARSLKVFELDL 2205
Query: 114 EKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLI 173
++ K + ++++K+ +L E K++ + + ++E + ++ + + ++ ++ +
Sbjct: 2206 VTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQL 2265
Query: 174 KE-NNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFE-----E 227
KE N A LC + ++ E++ E E L N+IEK+ E +
Sbjct: 2266 KELNEAVAALCG--DQEIMKATEQSLDPPIEEEH------QLRNSIEKLRARLEADEKKQ 2317
Query: 228 LRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTF 287
L V + E H L + ++++LE+E + ++E ++ + +++ L
Sbjct: 2318 LCVLQQLKESEHHADLLKG--RVENLERELEIARTNQEHAA----LEAENSKGEVETLKA 2371
Query: 288 LLEESRDKVNQLEEKT---KLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEED 344
+E + LE + + ENL ++K+ ELE I S + + Q+ +E
Sbjct: 2372 KIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENIL--QEKEQEK 2429
Query: 345 LQIATKTICQLTEEKETQMEESNKARAA---HSFVVTEFETTVCSLEELLRTEQQRLEKN 401
+Q+ K+ + E +TQ++E N+ AA E + S E L E+ +L +
Sbjct: 2430 VQMKEKSSTAM-EMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQG 2488
Query: 402 EDQLK----ILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIA 457
D+ K +L + E+E+ + K+ E+ LK + ++E L+ + Q E
Sbjct: 2489 LDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEH 2548
Query: 458 EELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELT 517
+ K EL L E+++ L+ + ++ + + K+L+ ELE K+
Sbjct: 2549 QLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFV 2608
Query: 518 SHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLK-QIENLQETETQLRNEL 576
NK++ + EL +E +M + QE+++ K + L+ +E ++ ++ QL+ EL
Sbjct: 2609 EKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLK-EL 2667
Query: 577 EYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESK-Q 635
ELK+ D C E +R+++ + E +++++AL + + +
Sbjct: 2668 TLENSELKKSLD---CMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVE 2724
Query: 636 LNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKL 695
+ Y K+ E L S K + ++ + ++E+ + + +LEE++K K+ + V
Sbjct: 2725 IQTYREKLTSKEECLSSQKLEI-DLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQ 2783
Query: 696 QKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSN 755
K+ ++R Q K+ ++ K + +I+++ S+L QE+ ++ ++
Sbjct: 2784 LKKENERAQGKMKLLIKSC-KQLEEEKEILQKELSQL----QAAQEKQKTGTVMDTKVDE 2838
Query: 756 LKAELLSVKKQLEIEREEKEK 776
L E+ +K+ LE + +E ++
Sbjct: 2839 LTTEIKELKETLEEKTKEADE 2859
Score = 116 bits (291), Expect = 9e-26
Identities = 173/855 (20%), Positives = 359/855 (41%), Gaps = 121/855 (14%)
Query: 36 KSFNKCTED------DFEFPFAK-TNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQ 88
K NKC ++ ++ K T L + + + D + Q+ N ++ C +
Sbjct: 334 KVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN-------AESARCSLE 386
Query: 89 EGLKDSDLENSEGLSR--------------VYSKLYKEAEKIKKWKVSTEAEL------- 127
+ +K+ + E E LSR + ++L +E ++ K +AEL
Sbjct: 387 QKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVK 446
Query: 128 RQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLK 187
+Q E+ L+E ++ + +A Q Q ++ +EE +EN +L+K ++ + +
Sbjct: 447 QQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKEN-NLLKSHSEQK-----AR 500
Query: 188 ETCARSAE--KTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLK- 244
E C AE K+ + + + N + E M+ +E Q ENS KL
Sbjct: 501 EVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAV 560
Query: 245 EDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
D EK + Q+ K+ +E + L ++++ E + K L LE + + +L+E+
Sbjct: 561 ADLEKQRDCSQDLLKK---REHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT 617
Query: 305 L----QSENLKQSIEKQHHLTKELEDIKVS-LQRSVSTQKALEEDLQIATKTICQLTEEK 359
L +SEN K + Q KE K++ L+ + TQ+ + +T+ E
Sbjct: 618 LFSCWKSENEK--LLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675
Query: 360 ETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSEL 419
++ + + S V + L++ Q+ +K + + + T +L + +L
Sbjct: 676 SVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDL 735
Query: 420 EEMTKLTNNK-----------EVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQE-- 466
E +L +N+ E E L+ +L K+ L N+ ++ L +Q+
Sbjct: 736 EHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQR---SLLAFDQQPA 792
Query: 467 -------LIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSH 519
+IG + E + ++ + V L+ LE++K N++L
Sbjct: 793 MHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQ 852
Query: 520 CNKLSLENKELTQE-----------TSDMTLELKNQQEDINNNKKQEERMLKQIENLQET 568
C +L E+ + ++ + + QED + ++ L +EN ++
Sbjct: 853 CEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKE 912
Query: 569 ETQLRNELEYVREELKQKR-------DEVKCKLDKSEENCNNLRKQVEN----KNKYIEE 617
L +++E + E+++ + D +K +L E + +K++ + + IEE
Sbjct: 913 LQLLNDKVETEQAEIQELKKSNHLLEDSLK-ELQLLSETLSLEKKEMSSIISLNKREIEE 971
Query: 618 LQQENKALKK-KGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKE-------IE 669
L QEN LK+ + +++N+ + K ++ ++ E++D Y++E E
Sbjct: 972 LTQENGTLKEINASLNQEKMNLIQ-KSESFANYIDEREKSISELSDQYKQEKLILLQRCE 1030
Query: 670 DKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKII---- 725
+ + E+L ++ + A+ + L E C+++ E+ L E ++ + +
Sbjct: 1031 ETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLA 1090
Query: 726 --EERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREA-- 781
EER+ L L E Q +LR+ + +N K+E +K+++ +EE+ K+++E
Sbjct: 1091 FAEERNQNLML--ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVND 1148
Query: 782 --KENTATLKEKKDK 794
+EN +K K K
Sbjct: 1149 LLQENEQLMKVMKTK 1163
Score = 114 bits (284), Expect = 6e-25
Identities = 189/820 (23%), Positives = 356/820 (43%), Gaps = 120/820 (14%)
Query: 53 TNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKE 112
+ LS +G N AL ++FL E + N Q +K++ EN L V ++
Sbjct: 1747 SELSFSGPN-----ALVPMDFLGNQEDIHN----LQLRVKETSNENLR-LLHVIEDRDRK 1796
Query: 113 AEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDL 172
E + +++L +E +L + K + EL+ N +S KLE ++++L
Sbjct: 1797 VESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQEL 1856
Query: 173 IKENNATRHLCNLLKETCARSAEKT--KKYEYEREETRQVYMDLNNNIEKMITAFEELRV 230
++ + L + L+ +S+ + + ++ ++D+ N + R+
Sbjct: 1857 LQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELS---------RI 1907
Query: 231 QAENSRLEMH-FKLKEDYEKIQHLEQEYKKEINDKEKQVSLL---LIQITEKENKMKDLT 286
++E + +E L+ D E +Q + +K+ +K+K + L L +T + N+++
Sbjct: 1908 RSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL 1967
Query: 287 FLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHL-------TKELEDIKVSLQRSVSTQ- 338
+ + ++QL EK K +++ L+ + H KE ++ +L VS
Sbjct: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELL 2027
Query: 339 ----------KALEEDLQIATKTIC-------QLTEEKETQMEESNKARAAHSFVVTEFE 381
++LE+D Q + T C QL +EKE ++ES +A S E
Sbjct: 2028 KDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKL 2087
Query: 382 TTVCSLEELLRTEQQ---RLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVEL-EELK 437
+LE L + + RL ++++ L ++K +E K K++ + E+LK
Sbjct: 2088 NVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK----KQLHIAEKLK 2143
Query: 438 KVLGEKETLLYENKQFEKIAEELKGTE--QELIGLLQAREK-EVHDLEIQLTAITTSEQY 494
+ E ++L + E + EL+ +E QEL+ L K EV L+ Q+ + S +
Sbjct: 2144 ERERENDSL---KDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKV 2200
Query: 495 YSKEVKDLKTELENEKLKNTELT---SHCNKLSLENKELTQETSDMTLELKNQQ----ED 547
+ ++ L++E EN + E S +KL K L +E +++K + E
Sbjct: 2201 FELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEM 2260
Query: 548 INNNKKQ----------EERMLKQIENLQ----ETETQLRNELEYVREELKQKRDEVKC- 592
+ N K+ ++ ++K E E E QLRN +E +R L+ + C
Sbjct: 2261 LQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCV 2320
Query: 593 --KLDKSEENCNNLRKQVENKNKYIE--ELQQENKALK---KKGTAESKQLNVYEI--KV 643
+L +SE + + L+ +VEN + +E QE+ AL+ KG E+ + + + +
Sbjct: 2321 LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSL 2380
Query: 644 NKLELELESAKQKFGEITDTYQKEIEDKKISE--------ENLLEEVEKAKVIADEAVKL 695
LEL++ + + + +T+ QKE E +ISE EN+L+E E+ KV E
Sbjct: 2381 RGLELDVVTIRSEKENLTNELQKEQE--RISELEIINSSFENILQEKEQEKVQMKEKSST 2438
Query: 696 QKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSN 755
E+ + ++ E VA + + K+KEQ SS LE+E +
Sbjct: 2439 AMEMLQTQLKELNERVAALHNDQEAC--------------KAKEQNLSSQVECLELEKAQ 2484
Query: 756 LKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKK 795
L L K + + L +E ++ L EKKD++
Sbjct: 2485 LLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL-EKKDEE 2523
Score = 100 bits (250), Expect = 5e-21
Identities = 140/669 (20%), Positives = 279/669 (41%), Gaps = 109/669 (16%)
Query: 226 EELRVQAENSRL-EMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKD 284
E ++ EN RL E+ L++ +KI H Q + ++N +E Q++ QI + E ++K
Sbjct: 61 EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKR 120
Query: 285 LTFLLEESRDKVNQLEEKTKLQSENLKQSI------EKQHHLTKELEDIKVSLQRSVSTQ 338
LE S+ + L N Q I Q++ + ED+K + V +
Sbjct: 121 CKSELERSQQAAQSAD--VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEER 178
Query: 339 KALEEDLQI-----ATKTICQLT-------------------EEKETQMEESNKARAAHS 374
K LE +++ A++T+ Q T +EK SN R
Sbjct: 179 KRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTP-- 236
Query: 375 FVVTEFETTVCSLEELLRTEQQRLEKNE-----------------DQLKILTMELQKKSS 417
+ +F + S E+ + + L+ + DQLK EL+ K +
Sbjct: 237 -IRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKIN 295
Query: 418 ELE------------------EMTKLTNNKEVELEELKKVLGE-KETLLYENKQFEKIAE 458
ELE E+ +VEL E +KVL + ++ L+ Q+++ +
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQAST 355
Query: 459 ELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTS 518
+ EQ+L L + + + E +A + EQ ++ K+ + EL ++ L
Sbjct: 356 KYTALEQKLKKLTEDLSCQRQNAE---SARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQ 412
Query: 519 HCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQI-------ENLQETETQ 571
C ++ + Q+ +M L+ + + + + K+Q E L++ E +
Sbjct: 413 ECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQI 472
Query: 572 LRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTA 631
NEL EE+K++ + +K ++ +L +++N + + + Q + +K K T+
Sbjct: 473 KENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTS 532
Query: 632 ESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE-KAKVIAD 690
+ L + K+N+ E L K K ++E ++ ++LL++ E + + D
Sbjct: 533 QETMLRDLQEKINQQENSLTLEKLKLA------VADLEKQRDCSQDLLKKREHHIEQLND 586
Query: 691 EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLE 750
+ K +KE +++ +E K +Y+++ EE+ L+ + E L +E
Sbjct: 587 KLSKTEKE--------SKALLSALELKKKEYEELKEEKT----LFSCWKSENEKLLTQME 634
Query: 751 IELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKL 810
E NL++++ LE + ++ E E TL+ ++ + +E ++ L
Sbjct: 635 SEKENLQSKI----NHLETCLKTQQIKSHEYNERVRTLEMDRENLS----VEIRNLHNVL 686
Query: 811 DSKAVPSQT 819
DSK+V +T
Sbjct: 687 DSKSVEVET 695
Score = 96.7 bits (239), Expect = 1e-19
Identities = 168/785 (21%), Positives = 329/785 (41%), Gaps = 114/785 (14%)
Query: 103 SRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGN------- 155
S+ SKL ++ + T + L KE +LQ +E ++ IQEL+ N
Sbjct: 882 SQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSL 941
Query: 156 -------EKVSLKLEE-------GIQENKDLIKENNATRHL---CNLLKETCARSAEKTK 198
E +SL+ +E +E ++L +EN + + N K + +E
Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFA 1001
Query: 199 KYEYEREET--------RQVYMDLNNNIEKMITAFEELR-----VQAENSRLEMHFKLKE 245
Y ERE++ +Q + L E+ A+E+L Q +NS+LE
Sbjct: 1002 NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECT 1061
Query: 246 DYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENK--MKDLTFLLEESRDKVNQLEEKT 303
+ + E E KE KE Q L + E+ N+ M +L + + R ++ + +
Sbjct: 1062 SLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNS 1121
Query: 304 KLQSENLKQSI----EKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEK 359
K ++ LKQ I E+Q+ + KE+ D+ ++ + K E + ++ I +E+
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKER 1181
Query: 360 ETQMEESN----KARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKK 415
E++ + N + + + LE +LR ++ +L+++E + + L ELQ
Sbjct: 1182 ESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTI 1241
Query: 416 SSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGL---LQ 472
+LE +N ++++ +E+ G K+ + +++ EL ++ + L LQ
Sbjct: 1242 RGDLE----TSNLQDMQSQEIS---GLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQ 1294
Query: 473 AREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLK----NTELTSHCNKLSLENK 528
++++LE ++ I +E+Y +L TEL + + + ++ KL E K
Sbjct: 1295 TTMNKLNELE-KICEILQAEKY------ELVTELNDSRSECITATRKMAEEVGKLLNEVK 1347
Query: 529 ELTQETSDMTLEL------------KNQQEDINNNKKQEERMLKQIENLQETETQLRNEL 576
L ++ + EL N+Q ++ E E+L ++ +++
Sbjct: 1348 ILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDES---NSYEHLTLSDKEVQMHF 1404
Query: 577 EYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALK------KKGT 630
++E+ + E K D ++C K E + Y++ L+ EN L +
Sbjct: 1405 AELQEKFLSLQSEHKILHD---QHCQMSSKMSELQT-YVDSLKAENLVLSTNLRNFQGDL 1460
Query: 631 AESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKA----K 686
+ QL + E V L + D+ ++ + +LL +E A +
Sbjct: 1461 VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQ 1520
Query: 687 VIADEAV--------KLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSK 738
DE +KE + E+ +L E ++ +K+ E+ +S+ G+ K+K
Sbjct: 1521 CSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQ-GIMKNK 1579
Query: 739 EQEQSSLRASLEIELSNLKAELLSVKKQLEIEREE-KEKLKREAKENTATLKEKKDKKTQ 797
E ++ LE LS+ + EL ++KQ E E+ ++KL E + L +K K+T+
Sbjct: 1580 EIQE------LEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEK-KQTE 1632
Query: 798 TFLLE 802
LE
Sbjct: 1633 QLSLE 1637
Score = 96.7 bits (239), Expect = 1e-19
Identities = 213/974 (21%), Positives = 392/974 (40%), Gaps = 205/974 (21%)
Query: 13 PRSSSSQVSAVKPQTLGGDSTFFK-------------------SFNKCTEDD-FEFPFAK 52
P SSS V + GDS+F++ S N+C+ D+ F +
Sbjct: 1474 PSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQE 1533
Query: 53 TNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSD--LENSE--GLSRVYSK 108
NL++ + S PA + V L L +V E +S ++N E L ++ S
Sbjct: 1534 ENLTR--KETPSAPA-KGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSS 1590
Query: 109 LYKEAEKIKKWKVSTEAELRQKESKLQ-ENRKIIEAQRKAIQELQFGNEKVSLKLEE--- 164
+E + ++K +S + +QK + + E + A++K ++L E L+L+
Sbjct: 1591 ERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDL 1650
Query: 165 ------GIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNI 218
GI + +D I+ N + C++ KE + + E+T K++ + + DLN +I
Sbjct: 1651 SSRSLLGI-DTEDAIQGRNES---CDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDI 1706
Query: 219 EKMI------------------TAFE---------------ELRVQAENSRLEMHFK-LK 244
EK+ T +E EL N+ + M F +
Sbjct: 1707 EKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQ 1766
Query: 245 EDYEKIQHLEQEYKKE-------INDKEKQVSLLLIQITEKENKMKDLTFLLEESR--DK 295
ED +Q +E E I D++++V LL ++ E ++K+ L+E + K
Sbjct: 1767 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLH-----LQEVQLMTK 1821
Query: 296 VNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQI-ATKTICQ 354
+ E K+ E K++ + L D + LQR V T + L DL++ A K+ +
Sbjct: 1822 IEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQR-VETSEGLNSDLEMHADKSSRE 1880
Query: 355 -----------------LTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL-LRTEQQ 396
L E E S KA H + E + V E+L L + +
Sbjct: 1881 DIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNE 1940
Query: 397 RLEKN----EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQ 452
+K E++L ++T E + EL+ M+K T + E++K+ E E+ E
Sbjct: 1941 NKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLH 2000
Query: 453 FEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDL---KTELENE 509
++AE +E LLQ +V +L T + Q K+ + L K ELEN+
Sbjct: 2001 CIQVAE---AEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQ 2057
Query: 510 ----------KLKNTE-LTSHCNKLSLENKELTQ-------ETSDMTLELKNQQEDINNN 551
+K +E L + ++ E +++ E + L L + QE+++
Sbjct: 2058 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQL 2117
Query: 552 KKQEERMLKQIENLQETETQLRNEL---EYVREELKQKRDEVKCKLDKSEENCN------ 602
++ E++ +IE ++ + + +L E + LK K + ++ +L SEEN
Sbjct: 2118 RRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDA 2177
Query: 603 -----------------------------NLRKQVENKNKYIEELQQENKALKK-----K 628
LR + EN K I+E Q + L K K
Sbjct: 2178 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFK 2237
Query: 629 GTAESKQLNVYEIKV-NKLELE-LESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAK 686
E K+ +IK +K +E L++ ++ E + E K +E++L +E+
Sbjct: 2238 SLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 2297
Query: 687 VIADEAVKLQK--EIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSS 744
+ + KL+ E D++ Q + + + E H +E + EL + ++ ++ +
Sbjct: 2298 QLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAAL 2357
Query: 745 LRASLEIELSNLKAELLSVKKQL---EIE----REEKEKLKREAKENTAT---------- 787
+ + E+ LKA++ + + L E++ R EKE L E ++
Sbjct: 2358 EAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSS 2417
Query: 788 ----LKEKKDKKTQ 797
L+EK+ +K Q
Sbjct: 2418 FENILQEKEQEKVQ 2431
Score = 53.9 bits (128), Expect = 7e-07
Identities = 99/506 (19%), Positives = 197/506 (38%), Gaps = 67/506 (13%)
Query: 465 QELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLS 524
QEL G L +KE + QL ++ + Q ++V++ KTE N K +N L C L
Sbjct: 21 QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLE 80
Query: 525 LENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELK 584
++++ E ++ Q+ +N+ KKQ E+ L EL+ + EL+
Sbjct: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEK--------------LEQELKRCKSELE 126
Query: 585 QKRDEVKCKLDKSEENCNNLRK---------QVENKNKYIEELQQENKALKKKGTAESKQ 635
+ + + D S CN +K Q + +KY + ++ NK ++++ E++
Sbjct: 127 RSQQAAQ-SADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAE- 184
Query: 636 LNVYEIKVNKLELELESAKQKFGEITD--------TYQKEIEDKKISEENLLEEVEK--- 684
V ++ K L A +I ++Q+E +S + + +
Sbjct: 185 --VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFS 242
Query: 685 AKVIADE----AVKLQKEIDKRCQHKI----AEMVALMEKHKHQYDKI---IEERDSELG 733
A + E + +I KR + + L+++ K Q ++ I E + L
Sbjct: 243 ASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQ 302
Query: 734 LYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKR---EAKENTATLKE 790
++ + + Q + L+++L K EL+ +K L R+E + +A L++
Sbjct: 303 GHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQ 362
Query: 791 KKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKR-----DYLWTSAKN 845
K K T+ + ++ Q + +S+ +R D K
Sbjct: 363 KLKKLTEDLSCQRQNAE---SARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKA 419
Query: 846 TLSTPLPKAYTVKTPTKPKLQQ----RENLNIPIEESKKK---RKMAFEFDINSDSSETT 898
L+ L +A + + +L + ++ L +EE K+K + AF+ ++
Sbjct: 420 RLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRR 479
Query: 899 DLLSMVSEEETLKTLYRNNNPPASHL 924
+ M E LK+ HL
Sbjct: 480 SMEEMKKENNLLKSHSEQKAREVCHL 505
Score = 46.6 bits (109), Expect = 1e-04
Identities = 59/276 (21%), Positives = 122/276 (44%), Gaps = 24/276 (8%)
Query: 33 TFFKSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLK 92
+F + NK T + E +++ + + + +K L+ + ++ LK
Sbjct: 2606 SFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLK 2665
Query: 93 DSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEA---ELRQKESKLQENRKIIEAQRKAIQ 149
+ LENSE L + ++K+ + K+ KV E +LR E++ + +++ ++
Sbjct: 2666 ELTLENSE-LKKSLDCMHKDQVE-KEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
Query: 150 ELQFGNEKVSLKLEEGIQENK---DLIKENNATRHLCNLLKETCARSAEKTKKYEYEREE 206
E+Q EK++ K EE + K DL+K + KE S + T + E ++
Sbjct: 2724 EIQTYREKLTSK-EECLSSQKLEIDLLKSS----------KEELNNSLKATTQILEELKK 2772
Query: 207 TRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEK 266
T+ + N ++K E R Q + L K E+ ++I E + +K+K
Sbjct: 2773 TKMDNLKYVNQLKK-----ENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQK 2827
Query: 267 QVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK 302
+++ ++ E ++K+L LEE + ++ +K
Sbjct: 2828 TGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDK 2863
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 131 bits (329), Expect = 4e-30
Identities = 187/820 (22%), Positives = 358/820 (43%), Gaps = 110/820 (13%)
Query: 36 KSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKV---NFLPVLEQVGNSDCHYQ---E 89
K K E + E K + + E + A +K + +L++ + Q E
Sbjct: 841 KPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETE 900
Query: 90 GLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIE---AQRK 146
L D++ E EGL + SK+ EA K+K+ E E + + R + + + ++
Sbjct: 901 NLMDAE-ERCEGL--IKSKILLEA-KVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKR 956
Query: 147 AIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREE 206
I +L+ KV + + K+L +E A L+E ++ ++ K + ++
Sbjct: 957 DIDDLELTLTKVEKEKHATENKVKNLSEEMTA-------LEENISKLTKEKKSLQEAHQQ 1009
Query: 207 TR---QVYMDLNNNIEKMITAFEE--------------LRVQAENSRLEMHFKLKEDYEK 249
T QV D N + K+ E+ LR E ++ ++ LK E
Sbjct: 1010 TLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQES 1069
Query: 250 IQHLE---QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQ 306
I LE Q+ ++++ KE ++S L +I +++ ++E + ++ +LEE+ + +
Sbjct: 1070 IMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAE 1129
Query: 307 SENLKQSIEKQHH-LTKELEDIKVSLQRS-------VSTQKALEEDLQIATKTICQLTEE 358
L+ IEKQ L +ELE+I L+ + + K E + Q + + + T +
Sbjct: 1130 -HTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 359 KETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSE 418
E K +A V E + +L+ + +Q+LEK + +LK ME+ +S
Sbjct: 1189 HEATAATLRKKQADS---VAELGEQIDNLQRV----KQKLEKEKSELK---MEIDDMASN 1238
Query: 419 LEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV 478
+E ++K +N E ++ E + + Q K Q G L R +E
Sbjct: 1239 IEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEK 1298
Query: 479 HDLEIQLTAITTSEQYYSKEVKDLKTELENE-KLKNT-----ELTSH-CN---------- 521
L QLT S+Q ++++++LK ++E E K KN + + H C+
Sbjct: 1299 ESLISQLTK---SKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQ 1355
Query: 522 --------KLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLR 573
LS N E+ Q + + + E++ KK+ + L++ E ET
Sbjct: 1356 EAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKC 1415
Query: 574 NELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY-------IEELQQENKALK 626
LE ++ L+ + +++ L++S C L K+ N +K ++E Q E +A +
Sbjct: 1416 ASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQ 1475
Query: 627 KKGTAESKQL----NVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEV 682
K+ + S +L N YE V++LE K EI+D ++ E K NL E
Sbjct: 1476 KESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGK----NLQEAE 1531
Query: 683 EKAKVIADEAVKLQ---KEIDKRCQH---KIAEMVALMEKHKHQYDKIIEERDSEL-GLY 735
+ K++ E LQ +E++ +H KI + + + K + D+ + E+D E+ L
Sbjct: 1532 KTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLK 1591
Query: 736 KSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKE 775
++ ++ +L++ L+ E+ + + + L +KK++E + E E
Sbjct: 1592 RNSQRAAEALQSVLDAEIRS-RNDALRLKKKMEGDLNEME 1630
Score = 117 bits (293), Expect = 5e-26
Identities = 166/769 (21%), Positives = 343/769 (44%), Gaps = 110/769 (14%)
Query: 170 KDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELR 229
K L+K A + + + KE R+ E+ + E R+E EKM++ +E
Sbjct: 841 KPLLKSAEAEKEMATM-KEDFERTKEELARSEARRKELE----------EKMVSLLQE-- 887
Query: 230 VQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLL 289
+ ++ +++ + E + E+ + I K +LL E K+K+LT L
Sbjct: 888 ------KNDLQLQVQSETENLMDAEERCEGLIKSK-----ILL------EAKVKELTERL 930
Query: 290 EESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIAT 349
EE + ++L K + NL+ +K L ++++D++++L + + A E ++ +
Sbjct: 931 EEEEEMNSELVAKKR----NLE---DKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983
Query: 350 KTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRT----EQQR--LEKNED 403
+ + L E +E + AH + + + + L++ EQQ LE + +
Sbjct: 984 EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLE 1043
Query: 404 QLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGT 463
Q K L +L++ +LE K++ ++LE K+ + EK + K+FE + K
Sbjct: 1044 QEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEK----LKKKEFELSQLQAKID 1099
Query: 464 EQELIGL-LQAREKE----VHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTS 518
++++ L Q + KE + +LE ++ A T K+ DL ELE E + E S
Sbjct: 1100 DEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELE-EISERLEEAS 1158
Query: 519 HCNKLSLE-NKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELE 577
+E NK+ E M +L ++ + + KQ +++ E Q+ N L+
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDL--EEATLQHEATAATLRKKQADSVAELGEQIDN-LQ 1215
Query: 578 YVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLN 637
V+++L++++ E+K ++D N L K N + ++ + +K K +++
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL-- 1273
Query: 638 VYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAK-VIADEAVKLQ 696
++++ + K L+ ++ GE++ +E+K E+L+ ++ K+K + + +L+
Sbjct: 1274 IHDLNMQKARLQTQN-----GELSH----RVEEK----ESLISQLTKSKQALTQQLEELK 1320
Query: 697 KEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNL 756
+++++ + K A M ++ +H D L + + +E+ +A L+ LS
Sbjct: 1321 RQMEEETKAKNA-MAHALQSSRHDCD-----------LLREQYEEEQEAKAELQRALSKA 1368
Query: 757 KAELL---------SVKKQLEIEREEKEKLKR--EAKENTATLKEK---KDKKTQTFLLE 802
+E+ ++++ E+E +K+ +R EA+ENT T K +K Q E
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGE 1428
Query: 803 TPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAK--------NTLSTPLPKA 854
++ L+ T+ + + D +++ K+ + A+ +LST L K
Sbjct: 1429 VEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKM 1488
Query: 855 YTVKTPTKPKLQ--QRENLNIPIEESKKKRKMAFEFDINSDSSETTDLL 901
+L+ +REN N+ E S ++A E N +E T L
Sbjct: 1489 RNAYEEVVDQLETLRRENKNLQEEISDLTEQIA-ETGKNLQEAEKTKKL 1536
Score = 111 bits (277), Expect = 4e-24
Identities = 160/792 (20%), Positives = 334/792 (42%), Gaps = 130/792 (16%)
Query: 88 QEGLKDSDLENSEGLSRVYSKLYKEA-EKIKKWKVSTEAELRQKESKLQENRKIIEAQRK 146
QE +DLE ++ K+ +E+ ++ K E +L++KE +L + + I+ ++
Sbjct: 1044 QEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQ- 1102
Query: 147 AIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREE 206
+ LQF +K +L+ I+E ++ I+ + R + AR E+ + E
Sbjct: 1103 -VHSLQF--QKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASG 1159
Query: 207 TRQVYMDLNNNIE----KMITAFEELRVQAENSRLEMHFK-------LKEDYEKIQHLEQ 255
+++N E KM EE +Q E + + K L E + +Q ++Q
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ 1219
Query: 256 EYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE--------------- 300
+ +KE ++ + ++ + I ++ D+ ++++
Sbjct: 1220 KLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNM 1279
Query: 301 EKTKLQSEN-------------LKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQI 347
+K +LQ++N + Q + + LT++LE++K ++ + A+ LQ
Sbjct: 1280 QKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQ- 1338
Query: 348 ATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ-QRLEKNEDQLK 406
+++ C L E Q EE +A+A +++ + V T+ QR E+ E+ K
Sbjct: 1339 SSRHDCDLLRE---QYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1395
Query: 407 ILTMELQKKSSELEEMTKLTNNKEVELEELKKVL-GEKETLLYE--------------NK 451
L LQ E EE T+ N+K LE+ K+ L GE E L+ + +
Sbjct: 1396 KLAQRLQ----EAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQR 1451
Query: 452 QFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELEN--- 508
F+K+ E K E L+A +KE L +L + + + +++ L+ E +N
Sbjct: 1452 NFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQE 1511
Query: 509 ----------EKLKNTELTSHCNKL-----------------SLENKE---------LTQ 532
E KN + KL SLE++E L+Q
Sbjct: 1512 EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQ 1571
Query: 533 ETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKC 592
S++ ++ + E+I K+ +R + ++++ + E + RN+ ++++++ +E++
Sbjct: 1572 VKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEI 1631
Query: 593 KLDKS-------EENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNK 645
+L S +++ ++ Q+++ ++++ + N+ LK +QL + E +
Sbjct: 1632 QLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLK-------EQLAIVERRNGL 1684
Query: 646 LELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQH 705
L ELE K + T +++SE+ LL+ ++ +++ + L K+ +
Sbjct: 1685 LLEELEEMKVALEQTERT-------RRLSEQELLDASDRVQLLHSQNTSL-INTKKKLEA 1736
Query: 706 KIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKK 765
IA+ A +E + Q + EE+ + + E+ L +K L K
Sbjct: 1737 DIAQCQAEVE-NSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1795
Query: 766 QLEIEREEKEKL 777
L+ +E E+L
Sbjct: 1796 DLQHRLDEAEQL 1807
Score = 105 bits (263), Expect = 2e-22
Identities = 141/681 (20%), Positives = 298/681 (43%), Gaps = 105/681 (15%)
Query: 83 SDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIE 142
S H + L++ E E + + L K ++ +W+ E + Q+ +L+E +K
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK--- 1395
Query: 143 AQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEY 202
KL + +QE +EN T + CA S EKTK+
Sbjct: 1396 ------------------KLAQRLQE----AEENTETAN------SKCA-SLEKTKQRLQ 1426
Query: 203 EREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN 262
E DL ++E+ TA L K + +++K+ E+K++++
Sbjct: 1427 GEVE------DLMRDLERSHTACATLD------------KKQRNFDKVL---AEWKQKLD 1465
Query: 263 DKEKQVSLLLIQITEKENK-MKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLT 321
+ + + ++ +KE++ + F + + ++V E + +++NL++ I LT
Sbjct: 1466 ESQAE-----LEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISD---LT 1517
Query: 322 KELEDIKVSLQRSVSTQKALEE---DLQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
+++ + +LQ + T+K +E+ DLQ+A + + E +E+++ + + S V +
Sbjct: 1518 EQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKIL---RVQLELSQVKS 1574
Query: 379 EFETTVCSLEELLRTEQQRLEKNEDQLK-ILTMELQKKSSELEEMTKLTNNKEVELEELK 437
E + V +E + ++ ++ + L+ +L E++ ++ L +L E +L E++
Sbjct: 1575 ELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDAL----RLKKKMEGDLNEME 1630
Query: 438 KVLGEKETLLYEN-KQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYS 496
LG + E K + +LK ++ L L++ E DL+ QL +
Sbjct: 1631 IQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE----DLKEQLAIVERRNGLLL 1686
Query: 497 KEVKDLKTELEN----EKLKNTELTSHCNKLSL---ENKELTQETSDMTLELKNQQEDIN 549
+E++++K LE +L EL +++ L +N L + ++ Q ++
Sbjct: 1687 EELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVE 1746
Query: 550 NN----KKQEERMLKQIENLQETETQLRNE------LEYVREELKQKRDEVKCKLDKSEE 599
N+ + EE+ K I + +L+ E LE +++ L+Q +++ +LD++E+
Sbjct: 1747 NSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1806
Query: 600 NC-NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFG 658
+KQ++ + EL+ E +K+G K + YE KV ++ + E +
Sbjct: 1807 LALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNIL 1866
Query: 659 EITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHK 718
+ D K ++ K S + EE A+E Q +R QH++ E + +
Sbjct: 1867 RLQDLVDK-LQAKVKSYKRQAEE-------AEEQANTQLSRCRRVQHELEEAAERADIAE 1918
Query: 719 HQYDKIIEERDSELGLYKSKE 739
Q +K + + ++G K +E
Sbjct: 1919 SQVNK-LRAKSRDVGSQKMEE 1938
Score = 90.1 bits (222), Expect = 9e-18
Identities = 109/577 (18%), Positives = 261/577 (45%), Gaps = 53/577 (9%)
Query: 436 LKKVLGEKETLLYENKQFEKIAEEL-------KGTEQELIGLLQARE----------KEV 478
LK EKE + + FE+ EEL K E++++ LLQ + + +
Sbjct: 844 LKSAEAEKEMATMK-EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENL 902
Query: 479 HDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMT 538
D E + + S+ +VK+L LE E+ N+EL + L + L ++ D+
Sbjct: 903 MDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLE 962
Query: 539 LELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLD--- 595
L L +++ + + + + + +++ L+E ++L E + ++E +Q D+++ + D
Sbjct: 963 LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVN 1022
Query: 596 -------KSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLEL 648
K E+ ++L +E + K +L++ + K +G + Q ++ +++ +K ++
Sbjct: 1023 GLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKR--KLEGDLKMSQESIMDLENDKQQI 1080
Query: 649 ELESAKQKFGEITDTYQKEIEDKKISE---ENLLEEVEKAKVIADEAVKLQKEIDKRCQH 705
E E K+K E++ Q +I+D+++ + ++E++ +E ++ + + + +
Sbjct: 1081 E-EKLKKKEFELSQ-LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEK 1138
Query: 706 KIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSV-K 764
+ +++ +E+ + ++ +++ + K +E E +R LE +A ++ K
Sbjct: 1139 QRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198
Query: 765 KQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNF 824
KQ + E E++ +N +K+K +K+ +E ++ +++ + + R
Sbjct: 1199 KQADSVAELGEQI-----DNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTC 1253
Query: 825 TSVDHGISKDK-RDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESK---- 879
+V+ S+ K +D T + L+ + T +++++E+L + +SK
Sbjct: 1254 RTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT 1313
Query: 880 ---KKRKMAFEFDINSDSSETTDLLSMVSEEETLKTLYRNNNPPASHLCVKTPKKAPSSL 936
++ K E + + ++ L S + + L+ Y + L + KA S +
Sbjct: 1314 QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAEL-QRALSKANSEV 1372
Query: 937 TTPGSTLKFGAIRKMREDRWAVIAKMDRKKKLKEAEK 973
+ + AI++ E AK ++L+EAE+
Sbjct: 1373 AQWRTKYETDAIQRTEE---LEEAKKKLAQRLQEAEE 1406
Score = 86.7 bits (213), Expect = 1e-16
Identities = 113/546 (20%), Positives = 235/546 (43%), Gaps = 37/546 (6%)
Query: 79 QVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENR 138
+ NS C E K E L R + + + K + + + L + + KL E++
Sbjct: 1409 ETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQ 1468
Query: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
+EA +K + L K+ EE + + + L +EN + + L E A + + +
Sbjct: 1469 AELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQ 1528
Query: 199 KYEYEREETRQVYMDLNNNIEKMITAFEE-----LRVQAENSRLEMHFKLKEDYEKIQHL 253
+ E ++ Q DL +E++ + E LRVQ E S+++ K EK + +
Sbjct: 1529 EAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKV-IEKDEEI 1587
Query: 254 EQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQS 313
EQ + E S+L +I + + ++ L ++ +N++E +L N +Q
Sbjct: 1588 EQLKRNSQRAAEALQSVLDAEIRSRNDALR----LKKKMEGDLNEME--IQLGHSN-RQM 1640
Query: 314 IEKQHHLTK---ELEDIKVSLQRSVSTQKALEEDLQIATK---TICQLTEEKETQMEESN 367
E Q HL +L+D ++ L ++ + + L+E L I + + + EE + +E++
Sbjct: 1641 AETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTE 1700
Query: 368 KARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTN 427
+ R + + V +LL ++ L + K L ++ + +E+E + +
Sbjct: 1701 RTRRLSEQELLDASDRV----QLLHSQNTSLINTK---KKLEADIAQCQAEVENSIQESR 1753
Query: 428 NKEVELEELKKVLGEKETLLYENKQFEKIA---EELKGTEQELIGLLQAREKEVHDLEIQ 484
N E E+ KK + + + E K+ + + E +K ++ + LQ R E ++
Sbjct: 1754 NAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAE--QLA 1808
Query: 485 LTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELT---QETSDMTLEL 541
L Q V++L+ EL+ E+ + E +K + KE+T +E L L
Sbjct: 1809 LKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRL 1868
Query: 542 KNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC 601
++ + + K +R ++ E T+ +++ EE ++ D + +++K
Sbjct: 1869 QDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKS 1928
Query: 602 NNLRKQ 607
++ Q
Sbjct: 1929 RDVGSQ 1934
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 131 bits (329), Expect = 4e-30
Identities = 158/716 (22%), Positives = 309/716 (43%), Gaps = 80/716 (11%)
Query: 106 YSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKII---EAQRKAIQELQFGNEKVSLKL 162
+ KL+ + + + K TE E+ + + Q+ + + EA+RK ++E K L
Sbjct: 832 WMKLFFKIKPLLK-SAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDL 890
Query: 163 EEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMI 222
+ +Q D + + C L + + K K+ EE ++ +L K+
Sbjct: 891 QLQVQSEADSLAD---AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLE 947
Query: 223 TAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKM 282
EL+ ++ L + EK +H + K + ++ + + ++++++ +
Sbjct: 948 DECSELKKDIDDLELTL-----AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKAL 1002
Query: 283 KDLTFL----LEESRDKVNQLEE-KTKL--QSENLKQSIEKQHHLTKELEDIKVSLQRSV 335
++ L+ DKVN L + KTKL Q ++L+ S+E++ L +LE K L+ +
Sbjct: 1003 QETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1062
Query: 336 STQKALEEDLQIATKTICQLTEEKE-------TQMEESNKARAAHSFVVTEFETTVCSLE 388
+ D++ + + + E+KE +++E+ + E + + L
Sbjct: 1063 KLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELG 1122
Query: 389 ELLRTEQQRLEKNEDQLKILTMELQKKSSELEE-------MTKLTNNKEVELEELKKVLG 441
E + E+ K E Q L+ EL++ S LEE +L +E E ++L++ L
Sbjct: 1123 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDL- 1181
Query: 442 EKETLLYE-------NKQFEKIAE------ELKGTEQELIGLLQAREKEVHDLEIQLTAI 488
E+ TL +E K + +AE L+ +Q+L + E DL AI
Sbjct: 1182 EEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAI 1241
Query: 489 TTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDI 548
+ ++ K + L+ ++ K K E N L+ + L E + + +L
Sbjct: 1242 SKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLD------ 1295
Query: 549 NNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQV 608
+++ ++ Q+ ++ TQ EL++ EE + ++ + L S +C+ LR+Q
Sbjct: 1296 -----EKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQY 1350
Query: 609 ENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEI 668
E + + ELQ +AL K + ++ YE + ELE AK+K + ++ +
Sbjct: 1351 EEEQEGKAELQ---RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHV 1407
Query: 669 EDKKISEENLLEEVEKAKV-IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEE 727
E +L EK K + +E L ++++ A ++K + +DK++ E
Sbjct: 1408 EAVNAKCASL----EKTKQRLQNEVEDLMLDVERS-----NAACAALDKKQRNFDKVLSE 1458
Query: 728 RDSELGLYKSK-EQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAK 782
+K K E+ Q+ L AS + E +L EL VK E ++ E L+RE K
Sbjct: 1459 -------WKQKYEETQAELEAS-QKESRSLSTELFKVKNVYEESLDQLETLRRENK 1506
Score = 127 bits (320), Expect = 4e-29
Identities = 193/792 (24%), Positives = 344/792 (43%), Gaps = 103/792 (13%)
Query: 62 IDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSE-GLSRVYSKLYKEAEKIKKWK 120
+D + A +K+ L Q D + D LE E +S + SK+ E + +
Sbjct: 1049 MDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDE----QAVE 1104
Query: 121 VSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATR 180
+ + ++++ +++++E + IEA+R + + + +S +LEE I E L + AT
Sbjct: 1105 IQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEE-ISER--LEEAGGATS 1161
Query: 181 HLCNLLKETCARSA-------EKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAE 233
L K+ A E T ++E R+ + D + + I + ++ + E
Sbjct: 1162 AQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLE 1221
Query: 234 NSRLEMHFK---LKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTF--- 287
+ E+ + L + E I + +K E QVS L + E++ + DLT
Sbjct: 1222 KEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRA 1281
Query: 288 -LLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQ 346
L E+ + QL+EK L S+ L +S + T+++E++K L+ + AL LQ
Sbjct: 1282 RLQTEAGEYSRQLDEKDALVSQ-LSRSKQAS---TQQIEELKHQLEEETKAKNALAHALQ 1337
Query: 347 IATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ-QRLEKNEDQL 405
+++ C L E Q EE + +A +++ + V T+ QR E+ E+
Sbjct: 1338 -SSRHDCDLLRE---QYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1393
Query: 406 KILTMELQKKSSELEEMTKLTNNKEVELEELKKVL-GEKETLLYE--------------N 450
K L LQ E EE + N K LE+ K+ L E E L+ +
Sbjct: 1394 KKLAQRLQ----EAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQ 1449
Query: 451 KQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEK 510
+ F+K+ E K +E L+A +KE L +L + + Y + + L+T
Sbjct: 1450 RNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKV---KNVYEESLDQLET------ 1500
Query: 511 LKNTELTSHCNKLSLENKELTQETSDMTLELK---NQQEDINNNKKQEERMLKQIE-NLQ 566
L ENK L QE SD+T ++ Q ++ KKQ E+ +I+ L+
Sbjct: 1501 ------------LRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALE 1548
Query: 567 ETETQLRNE---LEYVREELKQKRDEVKCKLDKSEENCNNLRKQ----VENKNKYIE-EL 618
E E L +E + ++ EL Q + EV K+ + +E + L++ VE ++ E+
Sbjct: 1549 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEI 1608
Query: 619 QQENKALKKKGTAESKQLNVYEIKV---NKLELE-LESAKQKFGEITDTYQKEIEDKKIS 674
+ N AL+ K E LN EI++ N+L E L + + G + +T Q ++D
Sbjct: 1609 RSRNDALRVKKKMEG-DLNEMEIQLNHANRLAAESLRNYRNTQGILKET-QLHLDDALRG 1666
Query: 675 EENLLEEVEKAKVIADEAVKLQKEIDK--------RCQHKIAEMVALMEKHKHQYDKIIE 726
+E+L E++ ++ A LQ EI++ KIAE L + Q +
Sbjct: 1667 QEDLKEQL---AIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQL--LHT 1721
Query: 727 ERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTA 786
+ S + K E + S L++ +E + + KK + E+LK+E ++ +A
Sbjct: 1722 QNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKE-QDTSA 1780
Query: 787 TLKEKKDKKTQT 798
L+ K QT
Sbjct: 1781 HLERMKKNLEQT 1792
Score = 100 bits (250), Expect = 5e-21
Identities = 127/649 (19%), Positives = 267/649 (41%), Gaps = 53/649 (8%)
Query: 83 SDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIE 142
S H + L++ E EG + + L K ++ +W+ E + Q+ +L+E +K
Sbjct: 1338 SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK--- 1394
Query: 143 AQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEY 202
KL + +QE ++ ++ NA C L++T R + +
Sbjct: 1395 ------------------KLAQRLQEAEEHVEAVNAK---CASLEKTKQRLQNEVEDLML 1433
Query: 203 EREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN 262
+ E + L+ E + + E ++ E+ KE + L E K N
Sbjct: 1434 DVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKES----RSLSTELFKVKN 1489
Query: 263 DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTK 322
E+ + L E +N ++++ L E+ + Q+ E K++ KQ +++ +
Sbjct: 1490 VYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIK----KQVEQEKCEIQA 1545
Query: 323 ELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFET 382
LE+ + SL+ ++ +L + + EK+ EE ++ + H+ VV ++
Sbjct: 1546 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD---EEIDQLKRNHTRVVETMQS 1602
Query: 383 TVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGE 442
T+ E R + R++K + +L + +L +L + +L E
Sbjct: 1603 TL-DAEIRSRNDALRVKKKMEG------DLNEMEIQLNHANRLAAESLRNYRNTQGILKE 1655
Query: 443 KETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDL 502
+ L + + ++ +E + LLQA E+ +L L S + +E+ D
Sbjct: 1656 TQLHLDDALRGQEDLKEQLAIVERRANLLQA---EIEELWATLEQTERSRKIAEQELLDA 1712
Query: 503 KTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQI 562
++ +NT L + KL + +L E ++ E +N +E M +++
Sbjct: 1713 SERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEEL 1772
Query: 563 ENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC-NNLRKQVENKNKYIEELQQE 621
+ Q+T L E +++ L+Q +++ +LD++E+ +KQ++ + EL+ E
Sbjct: 1773 KKEQDTSAHL----ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGE 1828
Query: 622 NKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEE 681
+ +K+ K L +E +V +L + E ++ + D K K + E
Sbjct: 1829 VENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEA 1888
Query: 682 VEKAKVIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQYDKIIEE 727
E++ + KLQ E+ ++R +++ L K + + KI E
Sbjct: 1889 EEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISAE 1937
Score = 50.4 bits (119), Expect = 8e-06
Identities = 78/363 (21%), Positives = 167/363 (46%), Gaps = 39/363 (10%)
Query: 441 GEKETLLYEN-KQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITT--SEQYYSK 497
G +LY + KQ K+ E + I +A EK + ++I T ++ ++
Sbjct: 711 GFPSRILYGDFKQRYKVLNASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKA 770
Query: 498 EVKDLKTELENEKLKN----TELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKK 553
+ L E+ +EKL T+ + +E +++ Q + N + +N
Sbjct: 771 GLLGLLEEMRDEKLAQIITRTQAVCRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVKHW 830
Query: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNK 613
++ +I+ L ++ + E+ ++EE ++ +DE+ K +E + ++ KN
Sbjct: 831 PWMKLFFKIKPLLKS-AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKND 889
Query: 614 YIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKI 673
++Q E +L A++++ IK NK++LE K E+T+ ++E
Sbjct: 890 LQLQVQSEADSL-----ADAEERCEQLIK-NKIQLEA-----KIKEVTERAEEE------ 932
Query: 674 SEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSEL- 732
EE E K + + DE +L+K+ID + +A +EK KH + ++ E+
Sbjct: 933 -EEINAELTAKKRKLEDECSELKKDIDD-----LELTLAKVEKEKHATENKVKNLTEEMA 986
Query: 733 GLYKS---KEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLK 789
GL ++ +E+ +L+ + + L +L+AE + ++ I + K KL+++ + +L+
Sbjct: 987 GLDETIAKLSKEKKALQETHQQTLDDLQAE----EDKVNILTKAKTKLEQQVDDLEGSLE 1042
Query: 790 EKK 792
++K
Sbjct: 1043 QEK 1045
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 130 bits (326), Expect = 8e-30
Identities = 206/864 (23%), Positives = 395/864 (45%), Gaps = 113/864 (13%)
Query: 111 KEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENK 170
KE + + + AEL K+ KL++ + +K I +L+ KV + E+ ENK
Sbjct: 924 KEVTERAEDEEEINAELTAKKRKLEDECSEL---KKDIDDLELTLAKV--EKEKHATENK 978
Query: 171 DLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETR---QVYMDLNNNIEKMITAFEE 227
N T + L ET A+ ++ K + ++T Q+ D N + K T E+
Sbjct: 979 ----VKNLTEEMAGL-DETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQ 1033
Query: 228 LRVQAENSRLEMHFKLKEDYEKIQH-LEQEYK---KEINDKEKQVSLLLIQITEKENKMK 283
E S LE KL D E+ + LE + K + D E L ++ +KE +M
Sbjct: 1034 QVDDLEGS-LEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMS 1092
Query: 284 DLTFLLEESRDKVNQLEEKTK-LQS--ENLKQSIEKQH-----------HLTKELEDIKV 329
+L +E+ + QL++K K LQ+ E L++ IE + L++ELE+I
Sbjct: 1093 NLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE 1152
Query: 330 SLQR---SVSTQKALEEDLQIATKTICQLTEEKETQMEESNKA-RAAHSFVVTEFETTVC 385
L+ + S Q + + + + + + EE Q E + A R H+ V E +
Sbjct: 1153 RLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQID 1212
Query: 386 SLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKET 445
SL+ + +Q+LEK + +LK ME+ +S +E ++K N E L+ L E +T
Sbjct: 1213 SLQRV----KQKLEKEKSELK---MEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKT 1265
Query: 446 LLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTE 505
+ ++ +++ EL + L +++ + + ++ ++ +Q +++++++LK +
Sbjct: 1266 ---KEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ 1322
Query: 506 LENE-KLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQE---DINNNKKQEERMLKQ 561
LE E K K+T +H + + + +L +E + E K + + N++ + R +
Sbjct: 1323 LEEETKAKST--LAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYE 1380
Query: 562 IENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQE 621
+ +Q TE ELE +++L Q+ + + ++ C +L K + +E+L +
Sbjct: 1381 TDAIQRTE-----ELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMID 1435
Query: 622 NK-------ALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKIS 674
+ AL KK K L ++ K + + ELE+++++ + + E+ K +
Sbjct: 1436 VERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE----SRSLSTELFKVKNA 1491
Query: 675 EENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELG- 733
E L+ +E K E LQ+EI + E +A KH H+ +K+ ++ D E
Sbjct: 1492 YEESLDHLETLK---RENKNLQQEIS-----DLTEQIAEGGKHIHELEKVKKQLDHEKSE 1543
Query: 734 LYKSKEQEQSSLR------ASLEIELSNLKAELLSVKKQLEIEREEKEKLKR------EA 781
L S E+ ++SL +++EL+ +K+E + +++ + EE ++LKR E+
Sbjct: 1544 LQTSLEEAEASLEHEEGKILRIQLELNQVKSE---IDRKIAEKDEELDQLKRNHLRVVES 1600
Query: 782 KENT--ATLKEKKD----KKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDK 835
++T A ++ + D KK L EI +L+ + RN + GI KD
Sbjct: 1601 MQSTLDAEIRSRNDALRIKKKMEGDLNEMEI--QLNHANRQAAEALRNLRNT-QGILKDT 1657
Query: 836 RDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQR--ENLNIPIEESKKKRKMAFEFDINSD 893
+ +L + + K + L Q E L +E +++ RKMA + + D
Sbjct: 1658 QLHLDDAIRGQDDL---KEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELL--D 1712
Query: 894 SSETTDLL-----SMVSEEETLKT 912
+SE LL S+++ ++ L+T
Sbjct: 1713 ASERVQLLHTQNTSLINTKKKLET 1736
Score = 122 bits (305), Expect = 2e-27
Identities = 163/736 (22%), Positives = 318/736 (43%), Gaps = 98/736 (13%)
Query: 107 SKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQR-------KAIQELQFGNEKVS 159
S L + E + + + ++++ +++++E + IEA+R K +L E++S
Sbjct: 1092 SNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1151
Query: 160 LKLEEG-------IQENKDLIKE-NNATRHLCNLLKETCARSAEKTKKYEYEREETRQVY 211
+LEE I+ NK E R L + A +A KK+ E +
Sbjct: 1152 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQI 1211
Query: 212 MDLNNNIEKMITAFEELRVQAEN--SRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVS 269
L +K+ EL+++ + S +E K K ++EK+ ++ EI KE++
Sbjct: 1212 DSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQ 1271
Query: 270 LLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKV 329
L+ +++ ++ ++ ES + QL+EK + S Q + T+++E++K
Sbjct: 1272 RLINELSAQKARLHT------ESGEFSRQLDEKDAMVS----QLSRGKQAFTQQIEELKR 1321
Query: 330 SLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEE 389
L+ + L LQ A C L E Q EE +A+A +++ + V
Sbjct: 1322 QLEEETKAKSTLAHALQSARHD-CDLLRE---QYEEEQEAKAELQRGMSKANSEVAQWRT 1377
Query: 390 LLRTEQ-QRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVL-GEKETLL 447
T+ QR E+ E+ K L LQ + EE + N+K LE+ K+ L E E L+
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQ----DAEEHVEAVNSKCASLEKTKQRLQNEVEDLM 1433
Query: 448 YE--------------NKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQ 493
+ + F+K+ E K +E L+A +
Sbjct: 1434 IDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQ------------------ 1475
Query: 494 YYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELK---NQQEDINN 550
KE + L TEL K E H L ENK L QE SD+T ++ ++
Sbjct: 1476 ---KESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEK 1532
Query: 551 NKKQEERMLKQIE-NLQETETQLRNE---LEYVREELKQKRDEVKCKLDKSEENCNNLRK 606
KKQ + +++ +L+E E L +E + ++ EL Q + E+ K+ + +E + L++
Sbjct: 1533 VKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKR 1592
Query: 607 Q----VENKNKYIE-ELQQENKALKKKGTAESKQLNVYEIKVNKLELE----LESAKQKF 657
VE+ ++ E++ N AL+ K E LN EI++N + L + +
Sbjct: 1593 NHLRVVESMQSTLDAEIRSRNDALRIKKKMEG-DLNEMEIQLNHANRQAAEALRNLRNTQ 1651
Query: 658 GEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKH 717
G + DT Q ++D +++L E++ ++ A +Q E++ ++ + E+
Sbjct: 1652 GILKDT-QLHLDDAIRGQDDLKEQL---AMVERRANLMQAEVE-----ELRASLERTERG 1702
Query: 718 KHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKL 777
+ ++ + + + L ++ + + LE ++S ++ E+ + ++ E+ +K
Sbjct: 1703 RKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKA 1762
Query: 778 KREAKENTATLKEKKD 793
+A LK+++D
Sbjct: 1763 ITDAAMMAEELKKEQD 1778
Score = 102 bits (254), Expect = 2e-21
Identities = 138/668 (20%), Positives = 276/668 (41%), Gaps = 86/668 (12%)
Query: 79 QVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENR 138
Q DC L++ E E + + + K ++ +W+ E + Q+ +L+E
Sbjct: 1338 QSARHDCDL---LREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEE-- 1392
Query: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
A++K Q LQ E V A C L++T R + +
Sbjct: 1393 ----AKKKLAQRLQDAEEHVE------------------AVNSKCASLEKTKQRLQNEVE 1430
Query: 199 KYEYEREETRQVYMDLNN---NIEKMITA----FEELRVQAENSRLEMH------FKLKE 245
+ E + + L+ N +K++ +EE + + E S+ E FK+K
Sbjct: 1431 DLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKN 1490
Query: 246 DYEK-IQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
YE+ + HLE K+E + ++++S L QI E + +L EK K
Sbjct: 1491 AYEESLDHLET-LKRENKNLQQEISDLTEQIAEGGKHIHEL---------------EKVK 1534
Query: 305 LQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQME 364
Q ++ K ++ LE+ + SL+ ++ +L I + EK+ E
Sbjct: 1535 KQLDHEKSELQTS------LEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKD---E 1585
Query: 365 ESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKN-EDQLKILTMELQKKSSELEEMT 423
E ++ + H VV ++T+ E R + R++K E L + ++L + + E
Sbjct: 1586 ELDQLKRNHLRVVESMQSTL-DAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEAL 1644
Query: 424 KLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEI 483
+ N + L++ + L + + + + E+L E+ L+QA EV +L
Sbjct: 1645 RNLRNTQGILKDTQLHLDDAI------RGQDDLKEQLAMVERRA-NLMQA---EVEELRA 1694
Query: 484 QLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKN 543
L + +E+ D ++ +NT L + KL + ++ E D+ E +N
Sbjct: 1695 SLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARN 1754
Query: 544 QQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC-N 602
+E M ++++ Q+T L E +++ ++Q +++ +LD++E+
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHL----ERMKKNMEQTVKDLQLRLDEAEQLALK 1810
Query: 603 NLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITD 662
+KQ++ + EL+ E ++ +K K L +E +V +L + E ++ + D
Sbjct: 1811 GGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1870
Query: 663 TYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEID---KRCQHKIAEMVALMEKHKH 719
K K + E E++ V + KLQ E++ +R +++ L K +
Sbjct: 1871 LVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSRE 1930
Query: 720 QYDKIIEE 727
+ K+I E
Sbjct: 1931 VHTKVISE 1938
Score = 99.4 bits (246), Expect = 1e-20
Identities = 147/712 (20%), Positives = 299/712 (41%), Gaps = 87/712 (12%)
Query: 237 LEMHFKLK------EDYEKIQHLEQEYKKEIND------KEKQVSLLLIQITEKENKMKD 284
++++FK+K E +++ ++++E++K + K K++ ++ + +++N D
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKN---D 890
Query: 285 LTFLLEESRDKVNQLEE------KTKLQSE----NLKQSIEKQHHLTKELEDIKVSLQRS 334
L ++ D + EE KTK+Q E + + E + + EL K L+
Sbjct: 891 LQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950
Query: 335 VSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTE 394
S K +DL++ + + E +++ + A + + +L+E +
Sbjct: 951 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010
Query: 395 QQRLEKNEDQLKILT---MELQKKSSELEEMTKLTNNKEVELEELKK------VLGEKET 445
L+ ED++ LT +L+++ +LE + ++LE K+ L ++ T
Sbjct: 1011 LDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQEST 1070
Query: 446 LLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTE 505
+ EN + +++ E+LK E E+ LQ + ++ L IQL Q +++L+ E
Sbjct: 1071 MDTENDK-QQLNEKLKKKEFEMSN-LQGKIEDEQALAIQLQKKIKELQ---ARIEELEEE 1125
Query: 506 LENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENL 565
+E E+ + + LS E +E+++ + Q I NKK+E K +L
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ---IEMNKKREAEFQKMRRDL 1182
Query: 566 QETETQ-------LR--------------NELEYVREELKQKRDEVKCKLDKSEENCNNL 604
+E+ Q LR + L+ V+++L++++ E+K +++ N +
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETV 1242
Query: 605 RKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTY 664
K N K L+ + +K K E +Q + E+ K L ES +F D
Sbjct: 1243 SKAKANFEKMCRTLEDQLSEIKTK--EEEQQRLINELSAQKARLHTESG--EFSRQLDEK 1298
Query: 665 QKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKI 724
+ ++ +++E+ K +E K + + Q + L E+++ +
Sbjct: 1299 DAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEE---- 1354
Query: 725 IEERDSELGLYKSK-EQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
+E +EL SK E + R E + EL KK+L ++ E+
Sbjct: 1355 -QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNS 1413
Query: 784 NTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSA 843
A+L EK ++ Q + + + ++ + RNF V +++ K+ Y T A
Sbjct: 1414 KCASL-EKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKV---LAEWKQKYEETQA 1469
Query: 844 K--------NTLSTPLPKAYTVKTPTKPKLQ--QRENLNIPIEESKKKRKMA 885
+ +LST L K + L+ +REN N+ E S ++A
Sbjct: 1470 ELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIA 1521
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 129 bits (325), Expect = 1e-29
Identities = 195/879 (22%), Positives = 376/879 (42%), Gaps = 156/879 (17%)
Query: 54 NLSKNGENIDSDPALQKVNFLPVLEQVGNS----DCHYQEGLKDSDLENSEGLSRVYSKL 109
NL++ E ++ D + K+N + Q + D H +E S + + L + +L
Sbjct: 989 NLTEEVEFLNED--ISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDEL 1046
Query: 110 YKEAEKIKKWKVSTEAELRQKESKLQENRKIIE----AQRKAIQELQFGNEKVSLKLEEG 165
E+ +K +++ E EL + E L+ NR+ +E +QR +EL+ ++S ++
Sbjct: 1047 EGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELS-QMNSK 1105
Query: 166 IQENKDLIKENNAT-RHLCNLLKETCAR-SAEKTK--KYEYEREETRQVYMDLNNNIEKM 221
++ K L+ + T + L +K+ + AE+T K E ER + Q DLN +E++
Sbjct: 1106 VENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEV 1165
Query: 222 ---------ITAFEELRVQAENSRLE---MHFK----------------LKEDYEKIQHL 253
IT +E + Q + +E +HF+ L+ E +Q +
Sbjct: 1166 GGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQVENLQQV 1225
Query: 254 EQEYKKEINDKEKQVSLLLI---QITEKENKMKDLTFLLEE-------SRDKVNQLE--- 300
+Q+ +K+ +D + +V LL Q+T + + L L EE DKV QL
Sbjct: 1226 KQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLANDL 1285
Query: 301 --EKTKLQSEN-------------LKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDL 345
+KTKL SE+ + Q ++ + T+++ED++ L++ +Q AL L
Sbjct: 1286 AAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHAL 1345
Query: 346 QIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQL 405
Q A + L E+ E + E + S V E E + QR E ED
Sbjct: 1346 QKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVI---QRTEDLEDAK 1402
Query: 406 KILTMELQKKSSEL-------EEMTKLTNNKEVEL----EELKKVLGEKETLLYENKQFE 454
K L + LQ+ + + + + + ++EL +L KV L + Q
Sbjct: 1403 KELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSG 1462
Query: 455 KIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTS-------EQYYSKEVKDLKTELE 507
K + K +E LL A +KEV L +L + + ++ +E K+L+ E+
Sbjct: 1463 KALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEIS 1522
Query: 508 N------EKLKNTELTSHCNKLSLENK--------------------------ELTQETS 535
N E KN KL E K EL + +
Sbjct: 1523 NLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKA 1582
Query: 536 DMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLD 595
++ +L + E+I N +++++ + +++ ++E + R E+ +++++++ +E++ +L
Sbjct: 1583 ELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLS 1642
Query: 596 KSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQ 655
+ + K + I++LQ + + + +Q+ V E + + L+ ELE
Sbjct: 1643 CANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELE---- 1698
Query: 656 KFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALME 715
++ ++ +++SEE LLE E+ + + L L +
Sbjct: 1699 ---DLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSL-----------------LSQ 1738
Query: 716 KHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKE 775
K K + D ++++E + + + E+ + +A+ IE +NL EL KKQ I E+
Sbjct: 1739 KKKLEADVARMQKEAEEVVQECQNAEEKAKKAA--IEAANLSEEL--KKKQDTIAHLER- 1793
Query: 776 KLKREAKENTAT-LKEKKDKKTQTFLLETPEIYWKLDSK 813
RE E T T L+++ + Q L+ + + KL+S+
Sbjct: 1794 --TRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESR 1830
Score = 119 bits (297), Expect = 2e-26
Identities = 163/748 (21%), Positives = 329/748 (43%), Gaps = 89/748 (11%)
Query: 145 RKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETC-----------ARS 193
+KA+++ +F E++ K QE DLI + A + ++E C AR
Sbjct: 872 QKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARV 931
Query: 194 AEKTKKYEYEREETRQV------YMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDY 247
E +++ E E E ++ D ++K I E + V++E + K+K
Sbjct: 932 KELSERVEEEEEINSELTARGRKLEDECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLT 991
Query: 248 EKIQHLEQEYKKEINDKEKQV----SLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT 303
E+++ L ++ K +N K V L + +E K+ L+ + +V++LE
Sbjct: 992 EEVEFLNEDISK-LNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQVDELEGAL 1050
Query: 304 KLQSENLKQSIEKQ-HHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
+ Q + + E++ H L L+ + S++ S+Q+ L E+L+ + Q+ ++
Sbjct: 1051 E-QERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQM----NSK 1105
Query: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEM 422
+E A V E +T + L+E L E+ K E + LT +L + LEE+
Sbjct: 1106 VENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEV 1165
Query: 423 -------TKLTNNKEVELEELKKVLGEKETLLYE------NKQFEKIAEELKGTEQELIG 469
++T +E + ++L + + E+ TL +E K+ EL+G + L
Sbjct: 1166 GGSSLAQLEITKKQETKFQKLHRDM-EEATLHFETTSASLKKRHADSLAELEGQVENLQQ 1224
Query: 470 LLQAREKEVHDLEIQLTAITTSEQYYSKEVKD-------LKTELENEKLKNTELTSHCNK 522
+ Q EK+ DL++++ + T + ++ + + L K ++T N
Sbjct: 1225 VKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLAND 1284
Query: 523 LSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQ---ETETQLRNELEYV 579
L+ + +L E+ + L+ ++ IN +++ +QIE+L+ E ET+ ++ L +
Sbjct: 1285 LAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHA 1344
Query: 580 RE----------ELKQKRDEVKCKLDK--SEENCNNLRKQVENKNKYI---EELQQENK- 623
+ E ++ EVK +L + S+ N ++ +++ +N I E+L+ K
Sbjct: 1345 LQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKE 1404
Query: 624 -------ALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEE 676
A + G A ++ ++ + ++L+LEL A G++ + ++ K++
Sbjct: 1405 LAIRLQEAAEAMGVANARNASLERAR-HQLQLELGDALSDLGKVRSAAAR-LDQKQLQSG 1462
Query: 677 NLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYK 736
L + ++ +E+ L K Q E++ L K+ Y++ I +++ K
Sbjct: 1463 KALADWKQKH---EESQALLDASQKEVQALSTELLKL----KNTYEESIVGQETLRRENK 1515
Query: 737 SKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKT 796
+ ++E S+L + NL E+ VKK +E EEK +++ +E L E+ + K
Sbjct: 1516 NLQEEISNLTNQVREGTKNL-TEMEKVKKLIE---EEKTEVQVTLEETEGAL-ERNESKI 1570
Query: 797 QTFLLETPEIYWKLDSKAVPSQTVSRNF 824
F LE E +L+ K NF
Sbjct: 1571 LHFQLELLEAKAELERKLSEKDEEIENF 1598
Score = 101 bits (252), Expect = 3e-21
Identities = 151/685 (22%), Positives = 285/685 (41%), Gaps = 90/685 (13%)
Query: 170 KDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELR 229
K L+K + + L KE CA+ + +K E++REE + + L +I L+
Sbjct: 849 KPLVKSSEVGEEVAGL-KEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLI-----LQ 902
Query: 230 VQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLL 289
+QAE L + E K + + KE++++ ++ + ++T + K++D F L
Sbjct: 903 LQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFEL 962
Query: 290 EESRDKVNQLEEKTKLQSENLKQSIE-KQHHLTKELEDIKVSLQRSVSTQKALEEDLQIA 348
++ D + E ++SE K++ E K +LT+E+E + + + K ++E Q
Sbjct: 963 KKEIDDL----ETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQ-- 1016
Query: 349 TKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKIL 408
+T+ L E+E ++ +KA V E E + + ++ L K E LK+
Sbjct: 1017 -QTLDDLHMEEE-KLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLN 1074
Query: 409 TMELQKKSSELEEMTKLTNNKEVELEEL-KKVLGEKETLLYENKQFEKIAEELKGTEQEL 467
++ S + + KE+EL ++ KV EK + K +++ ++K +++L
Sbjct: 1075 RESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKL 1134
Query: 468 --------------------IGLLQAREKEVHDLEIQLTAITTSEQ------YYSKEVKD 501
+ L R +EV + IT ++ + E
Sbjct: 1135 EAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEAT 1194
Query: 502 LKTELENEKLKN------TELTSHCNKLSLENKELTQETSDMTLE---LKNQQEDINNNK 552
L E + LK EL L ++L ++ SD+ LE L + E + K
Sbjct: 1195 LHFETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAK 1254
Query: 553 KQEERMLKQI-ENLQETE------TQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR 605
E++ E L E TQL N+L + +L + E +L++ E N L
Sbjct: 1255 ANAEKLCTLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLS 1314
Query: 606 KQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQ 665
++ N + IE+L+ + + K +A + L + + L + E ++ E+ T
Sbjct: 1315 REKSNFTRQIEDLRGQLEKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLS 1374
Query: 666 K---EIEDKKISEENLL----EEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHK 718
K E+ ++ EN + E++E AK + A++LQ+ + A +E+ +
Sbjct: 1375 KVNAEMVQWRMKYENNVIQRTEDLEDAK--KELAIRLQEAAEAMGVANARN--ASLERAR 1430
Query: 719 HQYDKIIEERDSELGL---------------------YKSKEQEQSSLRASLEIELSNLK 757
HQ + + S+LG +K K +E +L + + E+ L
Sbjct: 1431 HQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALS 1490
Query: 758 AELLSVKKQLEIEREEKEKLKREAK 782
ELL +K E +E L+RE K
Sbjct: 1491 TELLKLKNTYEESIVGQETLRRENK 1515
Score = 98.6 bits (244), Expect = 3e-20
Identities = 127/649 (19%), Positives = 294/649 (45%), Gaps = 78/649 (12%)
Query: 88 QEGLKDSDL--ENSEGLSRVYSKLYKEAEKIK----KWKVSTEAELRQKESKLQENRKII 141
Q+ +D DL E E V ++L++ K+ +W++ E + Q+ L++ +K +
Sbjct: 1346 QKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKEL 1405
Query: 142 EAQ-RKAIQELQFGNEKVS--------LKLEEGIQENKDLIKENNATRHLCNLLKETCAR 192
+ ++A + + N + + L+LE G D + + R L + +
Sbjct: 1406 AIRLQEAAEAMGVANARNASLERARHQLQLELG-----DALSDLGKVRSAAARLDQKQLQ 1460
Query: 193 SAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQH 252
S + ++ + EE+ Q +D + VQA ++ L KLK YE+
Sbjct: 1461 SGKALADWKQKHEES-QALLDASQK-----------EVQALSTEL---LKLKNTYEESIV 1505
Query: 253 LEQEYKKEINDKEKQVSLLLIQI---TEKENKMKDLTFLLEESRDKVNQLEEKTKLQSEN 309
++ ++E + ++++S L Q+ T+ +M+ + L+EE + +V E+T+
Sbjct: 1506 GQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETE---GA 1562
Query: 310 LKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKA 369
L+++ K H EL + K L+R +S + EE K C + + ++ ++ K+
Sbjct: 1563 LERNESKILHFQLELLEAKAELERKLSEKD--EEIENFRRKQQCTI-DSLQSSLDSEAKS 1619
Query: 370 RAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNK 429
R + + + E + +E L +++ + L L ++++ +L++ T+L +
Sbjct: 1620 RIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNS-- 1677
Query: 430 EVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAIT 489
+L+E V + +LL E+L+ +++ + E+E+ + ++
Sbjct: 1678 --DLKEQVAVAERRNSLLQSE------LEDLRSLQEQTERGRRLSEEELLEATERINLFY 1729
Query: 490 TSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDIN 549
T + K L+ ++ + + E+ C + K+ E ++++ ELK +Q+ I
Sbjct: 1730 TQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIA 1789
Query: 550 NNKKQEERMLKQIENLQETETQL--------RNELEYVREELKQKRDEVKCKLDKSEENC 601
+ ++ E M + I +LQ+ + R +++ + +++ E++ ++ +S E
Sbjct: 1790 HLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQ 1849
Query: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
R+ L++ K L + + K L+ + +++KL+L++++ KQ+ E+
Sbjct: 1850 RGARR-----------LERCIKELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQV-EVA 1897
Query: 662 DTYQKEIEDKKISEENLLEEV-EKAKVIADEAVKLQ---KEIDKRCQHK 706
+T + K +++ L EV E+A+V + KL+ +E K+ Q +
Sbjct: 1898 ETQANQYLSKYKKQQHELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
Score = 97.8 bits (242), Expect = 4e-20
Identities = 173/830 (20%), Positives = 335/830 (40%), Gaps = 160/830 (19%)
Query: 77 LEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKES-KLQ 135
LE+VG S + LE ++ + KL+++ E+ +T A L+++ + L
Sbjct: 1162 LEEVGGSSL--------AQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLA 1213
Query: 136 ENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNL----LKETCA 191
E +E ++ Q+L+ + L++++ + + + + LC L L E A
Sbjct: 1214 ELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATA 1273
Query: 192 R-----------SAEKTKKY----EYER--EETRQVYMDLNNNIEKMITAFEELRVQAEN 234
+ +A+KTK + E+ R EE + L+ E+LR Q E
Sbjct: 1274 KLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEK 1333
Query: 235 SRLEMHFK-------------LKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEK-EN 280
L+E YE+ EQE K E++ +V+ ++Q K EN
Sbjct: 1334 ETKSQSALAHALQKAQRDCDLLREQYEE----EQEVKAELHRTLSKVNAEMVQWRMKYEN 1389
Query: 281 KMKDLTFLLEESRDKVN-QLEEKTKLQ--SENLKQSIEK-QHHLTKELEDIKVSLQRSVS 336
+ T LE+++ ++ +L+E + + S+E+ +H L EL D L + S
Sbjct: 1390 NVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRS 1449
Query: 337 TQKALEEDLQIATKTIC---QLTEEKETQMEESNKARAAHSFVVTEFETTVCSL---EEL 390
L++ + K + Q EE + ++ S K A S + + + T +E
Sbjct: 1450 AAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQET 1509
Query: 391 LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELE---------------- 434
LR E + L++ L E K +E+E++ KL ++ E++
Sbjct: 1510 LRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESK 1569
Query: 435 -------------ELKKVLGEKETLL--YENKQ---FEKIAEELKGTEQ---ELIGLLQA 473
EL++ L EK+ + + KQ + + L + E+ L +
Sbjct: 1570 ILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKK 1629
Query: 474 REKEVHDLEIQLTAITTSEQYYSK-------EVKDLKTELENEKLKNTELTSHCNKLSLE 526
E++++++E+QL+ +K ++KDL+ +L++ N++L
Sbjct: 1630 MEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERR 1689
Query: 527 NKELTQETSDMTL--------------ELKNQQEDINNNKKQEERMLKQIENLQETETQL 572
N L E D+ EL E IN Q +L Q + L+ ++
Sbjct: 1690 NSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARM 1749
Query: 573 RNELEYVREELKQKRDEVKC----------KLDKSEENCNNLRKQVENKNKYIEELQQEN 622
+ E E V +E + ++ K +L K ++ +L + EN + I +LQ+
Sbjct: 1750 QKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRL 1809
Query: 623 KALKKKGTAES-KQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEE 681
++ S KQ+ E +V +LE ELE GEI + + + +++ E ++E
Sbjct: 1810 AEAEQMALMGSRKQIQKLESRVRELEGELE------GEIRRSAEAQRGARRL--ERCIKE 1861
Query: 682 VEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQE 741
+ Q E DK+ ++ + ++ Y + +E +++ Y SK ++
Sbjct: 1862 LT-----------YQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKK 1910
Query: 742 QSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEK 791
Q EL VK++ E+ + KLK +A+E ++E+
Sbjct: 1911 QQH--------------ELNEVKERAEVAESQVNKLKIKAREFGKKVQEE 1946
Score = 86.3 bits (212), Expect = 1e-16
Identities = 106/434 (24%), Positives = 198/434 (45%), Gaps = 62/434 (14%)
Query: 415 KSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAR 474
KSSE+ E ++ KE E +L+K L + E ++ ++ + L + +LI LQA
Sbjct: 853 KSSEVGE--EVAGLKE-ECAQLQKALEKSE---FQREELKAKQVSLTQEKNDLILQLQAE 906
Query: 475 EKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQET 534
++ + ++E Q + S+ VK+L +E E+ N+ELT+ KL E EL +E
Sbjct: 907 QETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKEI 966
Query: 535 SDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKL 594
D+ L +++ + + + + +++E L E ++L + V+E +Q D+ L
Sbjct: 967 DDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDD----L 1022
Query: 595 DKSEENCNNLRKQVENKNKYIEE----LQQENKALKKKGTAESKQLNVYEIKVNKLELEL 650
EE ++L K + ++E L+QE KA ++N E +++KLE L
Sbjct: 1023 HMEEEKLSSLSKANLKLEQQVDELEGALEQERKA----------RMNC-ERELHKLEGNL 1071
Query: 651 ESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEM 710
+ ++ +E+ + S+ +L EE+ K KE++ +++M
Sbjct: 1072 KLNRE-----------SMENLESSQRHLAEELRK------------KELE------LSQM 1102
Query: 711 VALMEKHK---HQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQL 767
+ +E K Q K ++E +++ K K + + + RA +E E ++L +L + ++L
Sbjct: 1103 NSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERL 1162
Query: 768 -EIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWK---LDSKAVPSQTVSRN 823
E+ +L+ K+ T K +D + T ET K DS A V N
Sbjct: 1163 EEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEGQV-EN 1221
Query: 824 FTSVDHGISKDKRD 837
V + KDK D
Sbjct: 1222 LQQVKQKLEKDKSD 1235
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 127 bits (320), Expect = 4e-29
Identities = 163/749 (21%), Positives = 330/749 (44%), Gaps = 90/749 (12%)
Query: 106 YSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQEL--QFGNEKVSLKL- 162
+ +L+ E E+ K L + E +++ ++ + A+ ++I++L ++ +S K
Sbjct: 267 FQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKAT 326
Query: 163 EEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMI 222
EE + + L + HL +LL++ K K+ REE M
Sbjct: 327 EEDHERTRRLAEAEMHVHHLESLLEQ-------KEKENSMLREE--------------MH 365
Query: 223 TAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLL----LIQITEK 278
FE A+ L+ ++K+ KI +E + + D E+++ +L + E+
Sbjct: 366 RRFENAPDSAKTKALQTVIEMKDS--KISSME----RGLRDLEEEIQMLKSNGALSTEER 419
Query: 279 ENKMKDLTFLLEESR---DKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSV 335
E +MK + S+ +KV QL+E+ + ++ +K L E+ +K L R
Sbjct: 420 EEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKD 479
Query: 336 STQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ 395
+ AL+ L+ T + E ++ES A+ + ++ +T V +L L ++
Sbjct: 480 TELLALQTKLETLTNQFSDSKQHIEV-LKESLTAKEQRAAIL---QTEVDALRLRLEEKE 535
Query: 396 QRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEEL-KKVLGEKETLLYENKQFE 454
L K Q++ + E ++ E+ ++ + + KE ++ L KK+ +E L + KQ
Sbjct: 536 TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMS 595
Query: 455 KIAEELKGTEQE----------LIGLLQAREKEVHDLEIQLTAITTSEQY----YSKEVK 500
+ E +K + + L L +E+ + L+ Q +Q Y K++K
Sbjct: 596 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLK 655
Query: 501 DLKT-------ELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKK 553
DLK +L ++ +L H + L+ + + + L+ ++E+ K
Sbjct: 656 DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC---LK 712
Query: 554 QEERMLKQIENLQETET--QLRNELEYVREELKQKRDE---VKCKLDKSEENCNNLRKQV 608
E ++ K E E ++ + ++++ E+ + +DE + ++D+ E + +
Sbjct: 713 MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK 772
Query: 609 ENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEI 668
+K+K I EL+++ K KK A K E K K LE A+++ + D+ Q ++
Sbjct: 773 NDKDKKIAELERQVKDQNKK-VANLKHKEQVEKK--KSAQMLEEARRREDNLNDSSQ-QL 828
Query: 669 EDKKISEENLLEEVEKA-----KVIADEAVKLQKEIDKR--CQHKIAEMVALMEKHKHQY 721
+D +++ +EE+E+A ++ A+ + L +E R + ++ E++ MEK K +
Sbjct: 829 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQEL 888
Query: 722 DKIIEERDSELGLYKSKEQEQSSLRAS----LEIELSNLKAELLSV---KKQLEIEREEK 774
+ + + S KE ++LRA LE E+ +K E L +K I E
Sbjct: 889 ESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE-EVLEMKQEALLAAISEKDANIALLEL 947
Query: 775 EKLKREAKENTATLKEKKDKKTQTFLLET 803
K++ +E A LK +KD+ Q +T
Sbjct: 948 SSSKKKTQEEVAALKREKDRLVQQLKQQT 976
Score = 105 bits (262), Expect = 2e-22
Identities = 162/785 (20%), Positives = 337/785 (42%), Gaps = 150/785 (19%)
Query: 91 LKDSDLENS-EGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQ 149
+K+S L +S + +S K+ ++K + S +++ +QE + ++ +A+Q
Sbjct: 174 VKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQ 233
Query: 150 ELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCAR--SAEKTKKYEYEREET 207
+ L+++ + + L ++++++R E C + E ++ E E
Sbjct: 234 D--------ELRIQRDLNQ---LFQQDSSSR-----TGEPCVAELTEENFQRLHAEHERQ 277
Query: 208 RQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFK-LKEDYEKIQHLEQEYKKEINDKEK 266
+ L +E+M ELR++ + L + +K+ E +Q K D E+
Sbjct: 278 AKELFLLRKTLEEM-----ELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
Query: 267 QVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIE-KQHHLTKELE 325
L E E + L LLE+ + + L E+ + EN S + K E++
Sbjct: 333 TRRL-----AEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK 387
Query: 326 DIKVS-LQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTV 384
D K+S ++R + + LEE++Q+ TEE+E +M++
Sbjct: 388 DSKISSMERGL---RDLEEEIQMLKSNGALSTEEREEEMKQM------------------ 426
Query: 385 CSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKE 444
E+ R+ + ++ +QLK EL K ++ EE+ K + E+ ++K+ L K+
Sbjct: 427 ----EVYRSHSKFMKNKVEQLK---EELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKD 479
Query: 445 T-LLYENKQFEKIAEELKGTEQELIGL---LQAREKEVHDLEIQLTAITT----SEQYYS 496
T LL + E + + ++Q + L L A+E+ L+ ++ A+ E +
Sbjct: 480 TELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN 539
Query: 497 KEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEE 556
K+ K ++ E + + E+ H K L+ KE ++ + + +++N QE + + +KQ
Sbjct: 540 KKTKQIQDMAEEKGTQAGEI--HDLKDMLDVKE--RKVNVLQKKIENLQEQLRDKEKQMS 595
Query: 557 RMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIE 616
+ +++++LQ T L + E L +K ++ ++ + + +++++N K ++
Sbjct: 596 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLK 655
Query: 617 ELQQENKALKKKGTAESKQLNVYEIK----------------VNKLELELESAKQKF--- 657
+L+++ L+ G K+ ++ ++K + LE+ LE K++
Sbjct: 656 DLKEKVSLLQ--GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM 713
Query: 658 -GEITDTYQKEIEDKKISE-----ENLLEEVEKAKVIADEAVKLQKEIDKRCQ------- 704
++ ++ +E + E ++L E+ + K DE+ K Q E+D+ +
Sbjct: 714 ESQLKKAHEAALEARASPEMSDRIQHLEREITRYK---DESSKAQAEVDRLLEILKEVEN 770
Query: 705 ------HKIAEMVALME---------KHKHQYDK------IIEERDSELGLYKSKEQEQS 743
KIAE+ ++ KHK Q +K + E R E L S +Q Q
Sbjct: 771 EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 830
Query: 744 SLR--------------------ASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
SLR A E+ L+ ++ + +KQ+E EK+K+E +
Sbjct: 831 SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELES 890
Query: 784 NTATL 788
A L
Sbjct: 891 MKAKL 895
Score = 100 bits (250), Expect = 5e-21
Identities = 129/645 (20%), Positives = 274/645 (42%), Gaps = 45/645 (6%)
Query: 86 HYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQR 145
H + L+ + ENS ++ + + K + T E+ K+SK+ + + R
Sbjct: 345 HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEM--KDSKISSMERGL---R 399
Query: 146 KAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYERE 205
+E+Q +L EE +E K + + ++ + N +++ + K ++E ++
Sbjct: 400 DLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKK 459
Query: 206 -------ETRQVYMDLNNNIEKMI---TAFEELRVQAENSR-----LEMHFKLKEDYEKI 250
E QV +L+ +++ T E L Q +S+ L+ KE I
Sbjct: 460 KAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAI 519
Query: 251 QHLE--------QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK 302
E +E + +N K KQ+ + + + ++ DL +L+ KVN L++K
Sbjct: 520 LQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK 579
Query: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
+ E L+ ++ L + ++ ++ + + LEE L +TI +L E+++
Sbjct: 580 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD 639
Query: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEM 422
E + + + + + V L+ L ++ L ++ L KK S L+ +
Sbjct: 640 EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 699
Query: 423 TKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLE 482
K+ E +++ L + E + ++++ ++ E+E+ K +++
Sbjct: 700 EIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 759
Query: 483 IQLTAITTSEQYYSKEVKDLK-TELENE-KLKNTELTSHCNKLSLENKELTQETSDMTLE 540
L + E K KD K ELE + K +N ++ + +K +E K+ Q M E
Sbjct: 760 RLLEILKEVEN--EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQ----MLEE 813
Query: 541 LKNQQEDINNNKKQ-EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEE 599
+ +++++N++ +Q ++ + K+ + ++E E LR ++ E + L + E
Sbjct: 814 ARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER--------EMVLAQEES 865
Query: 600 NCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGE 659
N KQVE +E+++QE +++K K ++ + L E + L E ++ E
Sbjct: 866 ARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLE 925
Query: 660 ITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQ 704
+ +K + LLE K +E L++E D+ Q
Sbjct: 926 MKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQ 970
Score = 95.9 bits (237), Expect = 2e-19
Identities = 152/736 (20%), Positives = 304/736 (41%), Gaps = 98/736 (13%)
Query: 223 TAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQI-TEKENK 281
T LR +N+ +++ +LKE + L +K++ KE ++S + I T +
Sbjct: 138 TVPHSLRQARDNTIMDLQTQLKEVLRENDLL----RKDVEVKESKLSSSMNSIKTFWSPE 193
Query: 282 MKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQH-HLTKELEDIKVSLQRSVSTQKA 340
+K L ++ K+ +E+ ++ E E QH +T + ++ +QR ++
Sbjct: 194 LKKERALRKDEASKITIWKEQYRVVQE------ENQHMQMTIQALQDELRIQRDLNQLFQ 247
Query: 341 LEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEK 400
+ + + +LTEE ++ ++ +A F++ + T+ +E + T++Q L
Sbjct: 248 QDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRK---TLEEMELRIETQKQTLNA 304
Query: 401 NEDQLKILTMELQKK------SSELEEMTKLTNNKEVELEELKKVLGEKE---TLLYE-- 449
++ +K L LQ K + E E T+ E+ + L+ +L +KE ++L E
Sbjct: 305 RDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEM 364
Query: 450 NKQFEKIAEELKGTEQELI-----GLLQAREKEVHDLEIQLT------AITTSEQ----- 493
+++FE + K + + + + E+ + DLE ++ A++T E+
Sbjct: 365 HRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMK 424
Query: 494 ----------YYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKN 543
+ +V+ LK EL +++ + EL L E ++ QE S EL
Sbjct: 425 QMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLA 484
Query: 544 QQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNN 603
Q + Q + IE L+E+ T ++ E+ D ++ +L++ E N
Sbjct: 485 LQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV----DALRLRLEEKETMLNK 540
Query: 604 LRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDT 663
K K I+++ +E + L+V E KVN L+ ++E+
Sbjct: 541 -------KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL---------- 583
Query: 664 YQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDK 723
Q+++ DK+ +L E V+ + +++ +AE +E+ K Q D+
Sbjct: 584 -QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA----LAEKERTIERLKEQRDR 638
Query: 724 IIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
E+ E+ YK ++ + L+ +LS +A LL +K+ K K
Sbjct: 639 DEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKT 698
Query: 784 NTATLKEKKDK--KTQTFLLETPEIYWKLDSKAVPS-----QTVSRNFTSVDHGISK--- 833
L++KK++ K ++ L + E L+++A P Q + R T SK
Sbjct: 699 LEIALEQKKEECLKMESQLKKAHEA--ALEARASPEMSDRIQHLEREITRYKDESSKAQA 756
Query: 834 --DKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAF----- 886
D+ + +N + K ++ K + ++ NL + KKK
Sbjct: 757 EVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARR 816
Query: 887 -EFDINSDSSETTDLL 901
E ++N S + D L
Sbjct: 817 REDNLNDSSQQLQDSL 832
Score = 87.8 bits (216), Expect = 4e-17
Identities = 127/556 (22%), Positives = 232/556 (41%), Gaps = 62/556 (11%)
Query: 88 QEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKA 147
QE L+D + + S RV S L + + E L +KE ++ ++ + +
Sbjct: 584 QEQLRDKEKQMSSLKERVKS-LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE 642
Query: 148 IQELQFGNEKVSLK-LEEGIQENKDLIKENNAT----RHLCNLLKETCARSAEKTKKYEY 202
QE + N K LK L+E + + + E A+ + + L + + + K E
Sbjct: 643 KQE-EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 701
Query: 203 EREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQE---YKK 259
E+ ++ + + + ++K A E R E S ++IQHLE+E YK
Sbjct: 702 ALEQKKEECLKMESQLKKAHEAALEARASPEMS------------DRIQHLEREITRYKD 749
Query: 260 EINDKEKQVSLLLIQITEKEN-------KMKDLTFLLEESRDKVNQLEEKTKLQSENLKQ 312
E + + +V LL + E EN K+ +L +++ KV L+ K +++ + Q
Sbjct: 750 ESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQ 809
Query: 313 SIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAA 372
+E+ L D LQ S+ + E+L+ A + Q+T E+E + + AR
Sbjct: 810 MLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR-- 867
Query: 373 HSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSEL-EEMTKLTNNKEV 431
T E V EELL +EK + +L+ + +L L E+ T LTN +
Sbjct: 868 -----TNAEKQV---EELLMA----MEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 915
Query: 432 ELEELKKVLGEKETLLYE-------NKQFEKIAEELKGTEQELIGLLQAREKEVHDL--E 482
+ L++VL K+ L N +++ K T++E+ L + +++ V L +
Sbjct: 916 RRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQ 975
Query: 483 IQLTAITTSEQYYSKEVKDLKTELENEKLKNT-------ELTSHCNKLSLENKELTQETS 535
Q ++ Y K + N K EL + +KL L LT
Sbjct: 976 TQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCH 1035
Query: 536 DMT-LELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKL 594
D L L+ + N ++ + E + T QL++ELE + + ++ L
Sbjct: 1036 DRDPLILRGLTPPASYNLDDDQAAWEN-ELQKMTRGQLQDELEKGERDNAELQEFANAIL 1094
Query: 595 DKSEENCNNLRKQVEN 610
+ ++C ++ +QV N
Sbjct: 1095 QQIADHCPDILEQVVN 1110
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 127 bits (319), Expect = 5e-29
Identities = 178/814 (21%), Positives = 343/814 (42%), Gaps = 127/814 (15%)
Query: 106 YSKLYK----EAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLK 161
Y +L K E E + K+ +E +++KE +++ R +++ + +E + KV
Sbjct: 1139 YDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH 1198
Query: 162 LEEGIQENKDLIK-ENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEK 220
E + ++ + E N T+ +KE + + +K + + + DL + I +
Sbjct: 1199 YNEEMSNLRNKYETEINITK---TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVR 1255
Query: 221 M---ITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITE 277
+ I E R +AE + L+ E +K QHLE E K+ + + + +
Sbjct: 1256 LNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSE----------D 1305
Query: 278 KENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVST 337
+ L + +DK ++E E K+ E ++ L+K + + +S
Sbjct: 1306 NARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEI---ISL 1362
Query: 338 QKALEEDLQIATKTICQLTEEKE-------TQMEESNKARAAHSFVVTEFETTVCSLEEL 390
+ E ++ I TI QLT +KE Q++ + + S + + T+ E
Sbjct: 1363 KNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTEN 1422
Query: 391 LRTEQ--------------QRLEKNEDQLKILTMELQKKS----SELEEMTKLTNNKEVE 432
LR + QR ++ E +L+ +T ++S L++ K +K E
Sbjct: 1423 LRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKE 1482
Query: 433 LEELKKVLGEKET-----LLYENKQFEKIAEELK---GTEQELIGLLQAREKEVHDLEIQ 484
+E LK+++ +KET L EN + +++ +L+ + E I L+ +E+E+ L I
Sbjct: 1483 IERLKQLI-DKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRID 1541
Query: 485 LTAIT----------TSEQYYSKEVKDLKTELENE--KLKNTELTSHCNKLSLENK---- 528
++ T Q KE++ K ++E E +LK T C + LE +
Sbjct: 1542 YERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM 1601
Query: 529 ------------ELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNEL 576
LTQ+ ++ K ++D+ + + L++ + QE +L +E+
Sbjct: 1602 RRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEV 1661
Query: 577 EYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKY-------IEELQQENKALKKKG 629
E +R +L Q+++ VK ++E + +K +E+K++ IE LQ + L K+
Sbjct: 1662 EALRRQLLQEQESVKQAHLRNE----HFQKAIEDKSRSLNESKIEIERLQSLTENLTKEH 1717
Query: 630 TAESKQLNVYEIKVNKLE--------------LELESAKQKFGEITDTYQKEIEDKKISE 675
++L ++ + L LEL S Q T Q I D +
Sbjct: 1718 LMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER 1777
Query: 676 ENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHK--HQYDKIIEERDSELG 733
ENL +E+EK + A EA +E +C + E +L+ K K Q ++ + EL
Sbjct: 1778 ENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELN 1837
Query: 734 LYKSKEQEQSSLRASLEIELSNLKAELLSVKKQ----------LEIERE----EKEKLKR 779
KS + ++ ++ LE E ++ +L K Q +E ERE EK L+
Sbjct: 1838 RAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRS 1897
Query: 780 EAKENTATLKEKKDKKTQTFLLETPEIYWKLDSK 813
E + A +K +++ + T E +L+++
Sbjct: 1898 EIERLQAEIKRIEERCRRKLEDSTRETQSQLETE 1931
Score = 115 bits (287), Expect = 3e-25
Identities = 144/729 (19%), Positives = 319/729 (43%), Gaps = 118/729 (16%)
Query: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
+ + K++++L+ N K+ + LEE ++ +D EN CN K
Sbjct: 1015 RFLSEMLKSLEDLKLKNTKIEV-LEEELRLARDANSEN------CNKNKFL--------- 1058
Query: 199 KYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK 258
++ Q Y + + + + EEL+ QAE L + Y +I
Sbjct: 1059 ------DQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQI-------- 1104
Query: 259 KEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLK-QSIEKQ 317
KE+N+K ++ L +I +++ + K + ++ ++ +QL++ + + ENL Q +E +
Sbjct: 1105 KELNEK---ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161
Query: 318 HHLTK---ELEDIKVSLQRSVSTQKALEEDL----------------------QIATKTI 352
+ + E+E ++V LQ + ++ E +L I TI
Sbjct: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTI 1221
Query: 353 CQLTEEKETQMEE--------SNKARAAHSFVVTEFETTVCSLEELLRTEQQRLE----- 399
+++ +KE + S + R +V ++ + + E+ R E+ L+
Sbjct: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281
Query: 400 ----KNEDQLKILTMELQKKSSE--------LEEMTKLTNNKEVELEELKKVLGE--KET 445
+ + L+I ++ ++ SE LEE K +K E+E LK E K
Sbjct: 1282 SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRR 1341
Query: 446 LLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTE 505
YEN ++++ ++E+I L E E++ + + +T ++ ++ + +
Sbjct: 1342 WEYEN----ELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKE---EDTSGYRAQ 1394
Query: 506 LENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQ---EDINNNKKQEERMLKQI 562
++N +N L+ +L + T+ + +++ Q+ +++ K+Q E L+Q+
Sbjct: 1395 IDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV 1454
Query: 563 ENLQ-ETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQE 621
++ E + + L+ + ++ K E++ +L + + N RK +E++N ++ +Q +
Sbjct: 1455 TQMRTEESVRYKQSLDDAAKTIQDKNKEIE-RLKQLIDKETNDRKCLEDENARLQRVQYD 1513
Query: 622 NKALKKKGTAESKQLNVYEIKVNKLELELESAKQ----KFGEITDTYQKEIEDKKISEEN 677
+ T +L V E ++ +L ++ E Q K +IT +Q +++ ++ ++
Sbjct: 1514 LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDIT-RFQNSLKELQLQKQK 1572
Query: 678 LLEEVEKAKVIADE----AVKLQKEID------KRCQHKIAEMVALMEK----HKHQYDK 723
+ EE+ + K A E KL++E++ K KI + +E+ K D
Sbjct: 1573 VEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDD 1632
Query: 724 IIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
+ ++RD G + K++ Q LR L E+ L+ +LL ++ ++ E ++ ++
Sbjct: 1633 LRQQRDVLDGHLREKQRTQEELR-RLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED 1691
Query: 784 NTATLKEKK 792
+ +L E K
Sbjct: 1692 KSRSLNESK 1700
Score = 95.1 bits (235), Expect = 3e-19
Identities = 124/558 (22%), Positives = 232/558 (41%), Gaps = 51/558 (9%)
Query: 106 YSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEG 165
Y + +A K + K L+Q K +RK +E + +Q +Q+ +K + E
Sbjct: 1465 YKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATET 1524
Query: 166 IQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEY-----EREETRQVYMDLNNNIEK 220
I NK ++E TR + + + R+ + + E + +Q + N +++
Sbjct: 1525 I--NKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKR 1582
Query: 221 MITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEY-------KKEINDKEKQVSLLLI 273
+ R + E M LKE KI +L Q+ K+ +D +Q +L
Sbjct: 1583 TASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDG 1642
Query: 274 QITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQR 333
+ EK+ ++L L E V L + + E++KQ+ + H K +ED SL
Sbjct: 1643 HLREKQRTQEELRRLSSE----VEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNE 1698
Query: 334 SVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRT 393
S + L+ + TK L EE E + R S ++ T+ L L+
Sbjct: 1699 SKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQI 1758
Query: 394 EQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK----KVLGEKETLLYE 449
R + + + L E + E+E+ K ++E K +V+ E+E+LL +
Sbjct: 1759 SNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVK 1818
Query: 450 NKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENE 509
K E+ LQ E E++ + L A T +Q E + ++ +L
Sbjct: 1819 IKVLEQDKAR-----------LQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQW 1867
Query: 510 KLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIE-NLQET 568
K + + K+ E ++ +E + + E++ Q +I K+ EER +++E + +ET
Sbjct: 1868 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEI---KRIEERCRRKLEDSTRET 1924
Query: 569 ETQLRNELEYVREEL-----------KQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEE 617
++QL E + E+ ++ + E + +D S+ + LRK+V Y +
Sbjct: 1925 QSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQ 1984
Query: 618 LQQE---NKALKKKGTAE 632
L + +K LK K + E
Sbjct: 1985 LIDKTTLDKLLKGKKSVE 2002
Score = 55.8 bits (133), Expect = 2e-07
Identities = 113/619 (18%), Positives = 250/619 (40%), Gaps = 84/619 (13%)
Query: 276 TEKENKMKDLTFLLE--ESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQR 333
T +EN ++ L+E + R ++ E + L++ L HH+T ++ ++K
Sbjct: 657 TNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQ-GSSHHITVKINELKSVQND 715
Query: 334 SVSTQKALEEDLQI-----ATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLE 388
S + + L + + ++ C L E ++ V + ++C++
Sbjct: 716 SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENING----VTDGYLNSLCTVR 771
Query: 389 ELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLY 448
LL Q + + ED LK+ L ++ + ++ K+ + L+++K L K++LL
Sbjct: 772 ALL----QAILQTEDMLKVYEARLTEEETVCLDLDKVEAYR-CGLKKIKNDLNLKKSLLA 826
Query: 449 ENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEI-----QLTAITTSEQYYSKEVK--- 500
K EL+ +Q I +++ ++DL++ ++T +T Q K++
Sbjct: 827 TMKT------ELQKAQQ--IHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRL 878
Query: 501 -DLKTELENEKLKNTELTSHCNKL--------SLENKELTQETSDMTL--ELKNQQEDIN 549
DL+ +++ + + C L SLE+ + + M E KN +I+
Sbjct: 879 WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938
Query: 550 NNKKQEERMLKQIE----NLQETETQL----------------RNELEYVREELKQKRDE 589
+ + E + K E ++++ E QL R ++ + Q+ +
Sbjct: 939 GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998
Query: 590 VKCK----LDKSEENCNNLRKQVEN------KNKYIEELQQENKALKKKGTAESKQLNVY 639
V + L +S + L + +++ KN IE L++E + + + +
Sbjct: 999 VHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL 1058
Query: 640 EIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEI 699
+ + K + E K K + + ++ D K +++NL + + K + ++ +L EI
Sbjct: 1059 DQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEI 1118
Query: 700 -DKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKA 758
D++ + K E ++ K+ YD++ + R E ++ E E E+ L+
Sbjct: 1119 EDEKRRRKSVE--DRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRV 1176
Query: 759 ELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQ 818
L + E K++ E + L+ K + + EI ++ +
Sbjct: 1177 LLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEI-------SMQKE 1229
Query: 819 TVSRNFTSVDHGISKDKRD 837
S+N + +S++ RD
Sbjct: 1230 DDSKNLRNQLDRLSRENRD 1248
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 127 bits (318), Expect = 7e-29
Identities = 166/759 (21%), Positives = 341/759 (44%), Gaps = 103/759 (13%)
Query: 109 LYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQE--LQFGNEKVSLKLEEGI 166
L K AE+ K+ A ++++ ++L+E + EA+RK ++E + EK L+L+ +
Sbjct: 839 LLKSAEREKEM-----ASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQ--V 891
Query: 167 QENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFE 226
Q +D + + C+ L + + K K+ E+ ++ +L K+
Sbjct: 892 QAEQDNLAD---AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECS 948
Query: 227 ELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLT 286
EL+ ++ L + EK +H + K + ++ + ++ ++T+++ +++
Sbjct: 949 ELKRDIDDLELTL-----AKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003
Query: 287 FL----LEESRDKVNQLEE---KTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQK 339
L+ DKVN L + K + Q ++L+ S+E++ + +LE K +
Sbjct: 1004 QQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAK----------R 1053
Query: 340 ALEEDLQIATKTICQLTEEKETQMEESNKAR----AAHSFVVTEFETTVCSLEELLRTEQ 395
LE DL++ ++I L +K+ Q++E K + A + + + + L++ L+ Q
Sbjct: 1054 KLEGDLKLTQESIMDLENDKQ-QLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
Query: 396 QRLEKNEDQLKI--------------LTMELQKKSSELEE-------MTKLTNNKEVELE 434
R+E+ E++L+ L+ EL++ S LEE ++ +E E +
Sbjct: 1113 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 435 ELKKVLGEKETLLYE------NKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAI 488
++++ L E+ TL +E K+ EL L + Q EKE + +++L +
Sbjct: 1173 KMRRDL-EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDV 1231
Query: 489 TTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMT---LELKNQQ 545
T++ + + +K + EK+ T L N+ + +E + +D+T +L+ +
Sbjct: 1232 TSNME------QIIKAKANLEKMCRT-LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN 1284
Query: 546 EDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR 605
+++ ++E ++ Q+ + T TQ +L+ EE + ++ + L + +C+ LR
Sbjct: 1285 GELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLR 1344
Query: 606 KQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQ 665
+Q E + + ELQ + L K + ++ YE + ELE AK+K + +
Sbjct: 1345 EQYEEETEAKAELQ---RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1401
Query: 666 KEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRC--QHKIAEMVALMEKHKHQYDK 723
+ +E +L EK K +LQ EI+ + A ++K + +DK
Sbjct: 1402 EAVEAVNAKCSSL----EKTK------HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1451
Query: 724 IIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAK- 782
I+ E +K K +E S S + E +L EL +K E E E KRE K
Sbjct: 1452 ILAE-------WKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1504
Query: 783 --ENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQT 819
E + L E+ +T + E ++ +L+++ + Q+
Sbjct: 1505 LQEEISDLTEQLGSSGKT-IHELEKVRKQLEAEKMELQS 1542
Score = 125 bits (315), Expect = 1e-28
Identities = 163/707 (23%), Positives = 312/707 (44%), Gaps = 74/707 (10%)
Query: 124 EAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLC 183
+ +L++ +++++E + +EA+R A +++ +S +LEE I E L + AT
Sbjct: 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE-ISER--LEEAGGATSVQI 1161
Query: 184 NLLKETCAR-------SAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSR 236
+ K+ A E T ++E R+ + D + + I + ++ + E +
Sbjct: 1162 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEK 1221
Query: 237 LEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKV 296
E FKL+ D + ++EQ K + N EK L Q+ E +K EE++ V
Sbjct: 1222 SE--FKLELD-DVTSNMEQIIKAKAN-LEKMCRTLEDQMNEHRSK-------AEETQRSV 1270
Query: 297 NQL-EEKTKLQSEN--LKQSIEKQHHL-----------TKELEDIKVSLQRSVSTQKALE 342
N L ++ KLQ+EN L + ++++ L T++LED+K L+ V + AL
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330
Query: 343 EDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ-QRLEKN 401
LQ A + C L E Q EE +A+A V+++ + V T+ QR E+
Sbjct: 1331 HALQSA-RHDCDLLRE---QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL 1386
Query: 402 EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK-KVLGEKETLLYENKQFEKIAEEL 460
E+ K L LQ E EE + N K LE+ K ++ E E L+ + ++ A L
Sbjct: 1387 EEAKKKLAQRLQ----EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAAL 1442
Query: 461 KGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHC 520
++ +L +++ + + +L + KE + L TEL K E H
Sbjct: 1443 DKKQRNFDKILAEWKQKYEESQSEL-------ESSQKEARSLSTELFKLKNAYEESLEHL 1495
Query: 521 NKLSLENKELTQETSDMTLELKNQQEDINN----NKKQEERMLKQIENLQETETQLRNE- 575
ENK L +E SD+T +L + + I+ K+ E ++ L+E E L +E
Sbjct: 1496 ETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEE 1555
Query: 576 --LEYVREELKQKRDEVKCKLDKSEENC-----NNLRKQVENKNKYIEELQQENKAL--K 626
+ + E Q + E++ KL + +E N+LR + E + N+AL K
Sbjct: 1556 GKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVK 1615
Query: 627 KKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAK 686
KK + ++ + N++ E + + + Q +++D + ++L E +
Sbjct: 1616 KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI---A 1672
Query: 687 VIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLR 746
++ LQ E++ ++ +V E+ + ++ + E + L S+ + +
Sbjct: 1673 IVERRNNLLQAELE-----ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQK 1727
Query: 747 ASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKD 793
++ +LS L+ E+ ++ E+ +K +A LK+++D
Sbjct: 1728 KKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQD 1774
Score = 125 bits (313), Expect = 3e-28
Identities = 168/840 (20%), Positives = 349/840 (41%), Gaps = 141/840 (16%)
Query: 89 EGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAI 148
EG + + + L R KL + + ++ + E + +Q + +L++ + A I
Sbjct: 1035 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI 1094
Query: 149 QELQFGNEKVSLKLEE---GIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYERE 205
++ Q ++ KL+E I+E ++ ++ R L+ +R E+ + E
Sbjct: 1095 EDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Query: 206 ETRQVYMDLNNNIE----KMITAFEELRVQAENSRLEMHFK-------LKEDYEKIQHLE 254
V +++N E KM EE +Q E + + K L E + +Q ++
Sbjct: 1155 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK 1214
Query: 255 Q-------EYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE------- 300
Q E+K E++D + ++ E + L + E R K + +
Sbjct: 1215 QKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLT 1274
Query: 301 -EKTKLQSEN--LKQSIEKQHHL-----------TKELEDIKVSLQRSVSTQKALEEDLQ 346
++ KLQ+EN L + ++++ L T++LED+K L+ V + AL LQ
Sbjct: 1275 SQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQ 1334
Query: 347 IATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQ-QRLEKNEDQL 405
A C L E Q EE +A+A V+++ + V T+ QR E+ E+
Sbjct: 1335 SARHD-CDLLRE---QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAK 1390
Query: 406 KILTMELQKKSSELEEMTKLTNNKEVELEELK-KVLGEKETLLYE--------------N 450
K L LQ E EE + N K LE+ K ++ E E L+ +
Sbjct: 1391 KKLAQRLQ----EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQ 1446
Query: 451 KQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQY-------YSKEVKDLK 503
+ F+KI E K +E L++ +KE L +L + + + + +E K+L+
Sbjct: 1447 RNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ 1506
Query: 504 TELEN--EKLKNTELTSH----------CNKLSLENK--------------------ELT 531
E+ + E+L ++ T H K+ L++ E
Sbjct: 1507 EEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Query: 532 QETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVK 591
Q +++ +L + E++ K+ R++ ++ + ET+ RNE V+++++ +E++
Sbjct: 1567 QIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEME 1626
Query: 592 CKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELE 651
+L + +KQV++ +++ Q + + + + + E + N L+ ELE
Sbjct: 1627 IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE 1686
Query: 652 SAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVI----------------------- 688
E+ ++ +K++E+ L+E E+ +++
Sbjct: 1687 -------ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739
Query: 689 -ADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRA 747
+EAV+ + +++ + I + + E+ K + D + + ++ + Q L
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 748 SLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLK--EKKDKKTQTFLLETPE 805
+ +I L K +L ++ ++ RE + +L+ E K N ++K K +++ + +T E
Sbjct: 1800 AEQIALKGGKKQLQKLEARV---RELENELEAEQKRNAESVKGMRKSERRIKELTYQTEE 1856
Score = 107 bits (268), Expect = 4e-23
Identities = 160/713 (22%), Positives = 324/713 (45%), Gaps = 69/713 (9%)
Query: 192 RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQ 251
+SAE+ K+ +EE + L +EK +EL E L ++ +Q
Sbjct: 841 KSAEREKEMASMKEE----FTRLKEALEKSEARRKELE--------EKMVSLLQEKNDLQ 888
Query: 252 HLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLE-EKTKLQSE-- 308
Q + + D E++ L+ + E K+K++ LE+ + +L +K KL+ E
Sbjct: 889 LQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECS 948
Query: 309 NLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNK 368
LK+ I+ ++E K + + V K L E++ + I +LT+EK+ ++E+++
Sbjct: 949 ELKRDIDDLELTLAKVEKEKHATENKV---KNLTEEMAGLDEIIAKLTKEKKA-LQEAHQ 1004
Query: 369 ARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNN 428
+ T+ + L + LE + +Q K + M+L++ +LE KLT
Sbjct: 1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 429 KEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIG-LLQAREKE----VHDLEI 483
++LE K+ L E+ + K FE A + +++ +G LQ + KE + +LE
Sbjct: 1065 SIMDLENDKQQLDER----LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEE 1120
Query: 484 QLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLE-NKELTQETSDMTLELK 542
+L A T+ K DL ELE E + E + +E NK+ E M +L
Sbjct: 1121 ELEAERTARAKVEKLRSDLSRELE-EISERLEEAGGATSVQIEMNKKREAEFQKMRRDL- 1178
Query: 543 NQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCN 602
++ + + K +++ E Q+ N L+ V+++L++++ E K +LD N
Sbjct: 1179 -EEATLQHEATAAALRKKHADSVAELGEQIDN-LQRVKQKLEKEKSEFKLELDDVTSNME 1236
Query: 603 NLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITD 662
+ K N K L+ + + K AE Q +V ++ + +L+ E+ GE++
Sbjct: 1237 QIIKAKANLEKMCRTLEDQMNEHRSK--AEETQRSVNDLTSQRAKLQTEN-----GELS- 1288
Query: 663 TYQKEIEDKKISEENLLEEVEKAKVIADEAVK-LQKEIDKRCQHKIAEMVALMEKHKHQY 721
+++++K E L+ ++ + K+ + ++ L++++++ + K A + ++ +H
Sbjct: 1289 ---RQLDEK----EALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNA-LAHALQSARHDC 1340
Query: 722 DKIIEERDSELGLYKSKEQEQSSL-RASLEIELSNLKAELLSVKKQLEIEREEKEKLKR- 779
D + E+ + E ++K + Q L +A+ E+ K E ++++ E+E +K+ +R
Sbjct: 1341 DLLREQYEEET---EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1397
Query: 780 -EAKENTATLKEK---KDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDK 835
EA+E + K +K E ++ ++ + + + + D +++ K
Sbjct: 1398 QEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1457
Query: 836 RDY------LWTSAK--NTLSTPLPKAYTVKTPTKPKLQ--QRENLNIPIEES 878
+ Y L +S K +LST L K + L+ +REN N+ E S
Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1510
Score = 104 bits (260), Expect = 4e-22
Identities = 128/626 (20%), Positives = 271/626 (43%), Gaps = 57/626 (9%)
Query: 79 QVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENR 138
Q DC + + E L RV SK E + +W+ E + Q+ +L+E +
Sbjct: 1334 QSARHDCDLLREQYEEETEAKAELQRVLSKANSE---VAQWRTKYETDAIQRTEELEEAK 1390
Query: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
K + AQR +QE + E V+ K +++ K + +N + ++ + A +A K
Sbjct: 1391 KKL-AQR--LQEAEEAVEAVNAKCSS-LEKTKHRL-QNEIEDLMVDVERSNAAAAALDKK 1445
Query: 199 KYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEK-IQHLEQEY 257
+ +++ + + E+ + E + +A + E+ FKLK YE+ ++HLE +
Sbjct: 1446 QRNFDK-----ILAEWKQKYEESQSELESSQKEARSLSTEL-FKLKNAYEESLEHLET-F 1498
Query: 258 KKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK-LQSENLKQSIEK 316
K+E + ++++S DLT L S +++LE+ K L++E ++
Sbjct: 1499 KRENKNLQEEIS--------------DLTEQLGSSGKTIHELEKVRKQLEAEKME----- 1539
Query: 317 QHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFV 376
L LE+ + SL+ + + I + EK+ +ME+ A+ H V
Sbjct: 1540 ---LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ---AKRNHLRV 1593
Query: 377 VTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEEL 436
V +T++ E R E R++K + +L + +L ++ + +++ L
Sbjct: 1594 VDSLQTSL-DAETRSRNEALRVKKKMEG------DLNEMEIQLSHANRMAAEAQKQVKSL 1646
Query: 437 KKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYS 496
+ +L + + L + + +E + LLQA E+ +L + S +
Sbjct: 1647 QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA---ELEELRAVVEQTERSRKLAE 1703
Query: 497 KEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEE 556
+E+ + ++ +NT L + K+ + +L E + E +N +E
Sbjct: 1704 QELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAA 1763
Query: 557 RMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC-NNLRKQVENKNKYI 615
M ++++ Q+T L E +++ ++Q +++ +LD++E+ +KQ++ +
Sbjct: 1764 MMAEELKKEQDTSAHL----ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARV 1819
Query: 616 EELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISE 675
EL+ E +A +K+ K + E ++ +L + E ++ + D K K +
Sbjct: 1820 RELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYK 1879
Query: 676 ENLLEEVEKAKVIADEAVKLQKEIDK 701
E E+A + K+Q E+D+
Sbjct: 1880 RQAEEAEEQANTNLSKFRKVQHELDE 1905
Score = 90.1 bits (222), Expect = 9e-18
Identities = 106/546 (19%), Positives = 223/546 (40%), Gaps = 90/546 (16%)
Query: 95 DLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFG 154
D+E S + K + +KI L + + K +E++ +E+ +K + L
Sbjct: 1431 DVERSNAAAAALDKKQRNFDKI----------LAEWKQKYEESQSELESSQKEARSLSTE 1480
Query: 155 NEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDL 214
K+ EE ++ + +EN + + L E S + + E R++ M+L
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMEL 1540
Query: 215 NNNIEKMITAFEE-----LRVQAENSRL--EMHFKLKEDYEKIQHLEQEYKK-------- 259
+ +E+ + E LR Q E +++ E+ KL E E+++ ++ + +
Sbjct: 1541 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 1600
Query: 260 --------------------EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQL 299
++N+ E Q+S E + ++K L LL++++ +++
Sbjct: 1601 LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1660
Query: 300 EEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEK 359
EN+ + + L ELE+++ ++++ ++K E++L ++ + L +
Sbjct: 1661 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1720
Query: 360 ETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSEL 419
+ + + K A S + TE E V + R +++ +K ++ EL+K+
Sbjct: 1721 TSLINQKKKMDADLSQLQTEVEEAV----QECRNAEEKAKKAITDAAMMAEELKKEQDTS 1776
Query: 420 EEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVH 479
+ ++ N E +++L+ L E E + LKG +++L
Sbjct: 1777 AHLERMKKNMEQTIKDLQHRLDEAEQIA------------LKGGKKQL------------ 1812
Query: 480 DLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTL 539
Q V++L+ ELE E+ +N E K KELT +T +
Sbjct: 1813 -------------QKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRK 1859
Query: 540 ELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEE 599
L Q+ ++ + + + +Q E +E ++ V+ EL DE + + D +E
Sbjct: 1860 NLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHEL----DEAEERADIAES 1915
Query: 600 NCNNLR 605
N LR
Sbjct: 1916 QVNKLR 1921
Score = 42.4 bits (98), Expect = 0.002
Identities = 43/226 (19%), Positives = 97/226 (42%), Gaps = 46/226 (20%)
Query: 109 LYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQE 168
L+ + + K +A+L Q +++++E A+QE + EK + +
Sbjct: 1716 LHSQNTSLINQKKKMDADLSQLQTEVEE----------AVQECRNAEEKAKKAITDAAMM 1765
Query: 169 NKDLIKENNATRHLCNLLKETCARSAEKT-KKYEYEREETRQVYM--------------- 212
++L KE + + HL E ++ E+T K ++ +E Q+ +
Sbjct: 1766 AEELKKEQDTSAHL-----ERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVR 1820
Query: 213 DLNNNIE--------------KMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK 258
+L N +E K +EL Q E R + +L++ +K+Q + YK
Sbjct: 1821 ELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNL-LRLQDLVDKLQLKVKAYK 1879
Query: 259 KEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
++ + E+Q + L + + ++++ + + + +VN+L K++
Sbjct: 1880 RQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1925
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 127 bits (318), Expect = 7e-29
Identities = 177/875 (20%), Positives = 375/875 (42%), Gaps = 129/875 (14%)
Query: 108 KLYKEAEKIKKWKVSTEAE---LRQKESKLQENRKIIEAQRKAIQ-ELQFGNEKVSLKLE 163
+L+ + + + K S E E L + K Q+ + I+ +++ EL+ + SLK
Sbjct: 1358 ELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEI---EKSLKHH 1414
Query: 164 EGIQEN-----KDLIKENNATRHLCNLLKETCAR---SAEKTKKYEYEREETRQVYMDLN 215
E I + K L+K + R LL E + + EKTK + + ++ +
Sbjct: 1415 EDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTE 1474
Query: 216 NNIEKM-----------ITAFEELR-VQAENSRLEMHFKLKE----------------DY 247
++ E++ + A ++LR +QA+ LE H K+K+ D+
Sbjct: 1475 SDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQH-KIKQEEILKEINKIVAAKDSDF 1533
Query: 248 EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQS 307
+ + +++ +E+ +K + + +K+ LL+ R ++ +L+ + Q
Sbjct: 1534 QCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQ 1593
Query: 308 ENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESN 367
+ + + H +EL ++ S+ V + L+E L++ + EK + E
Sbjct: 1594 QEMAVLDRQLGHKKEELHLLQGSM---VQAKADLQEALRLGETEVT----EKCNHIREVK 1646
Query: 368 KARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTN 427
SF E + + L +Q +EK E+ L+++ ++ K +EL+ + +
Sbjct: 1647 SLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQ 1706
Query: 428 NKEVELEELK-------KVLGEKETLLYENK----QFEKIAEELKGTEQELIGLLQAREK 476
+ EL+ LK L + + + E K ++I+++ KG + LL+ ++
Sbjct: 1707 LENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKR 1766
Query: 477 EVHDLEIQLTAITTSEQYYSKEVKDL--KTELENEKLKNTELT------------SHCNK 522
E+ + + A+ + + SKE +DL K ++ +KL T+ S+ K
Sbjct: 1767 EIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEK 1826
Query: 523 LSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREE 582
L L ++L QE + + + DI+ ++Q + + + +LQE +++ L +++
Sbjct: 1827 LELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQD 1886
Query: 583 LKQK--------RDEVKCKLDKSE--ENCNNLRKQVENKNKYIEELQQENKALKKKGTAE 632
L ++ + + D SE + +K+ E K + ++ LQ E + K K +
Sbjct: 1887 LLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQ 1946
Query: 633 SKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEA 692
+ + E +LE++K E +KE+ D+K + +L +V + A+E
Sbjct: 1947 EMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKV----LAAEER 2002
Query: 693 VKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSEL----GLYKSKEQEQSSLRAS 748
V+ +E ++ C+ +EK Q + + ER+ +L G + ++E S+RA
Sbjct: 2003 VRTLQEEERWCES--------LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRAD 2054
Query: 749 LEI-------ELSNLKAELLSVKKQLEIEREEKEK-LKREAKENTATLKE---------- 790
+ E + ++ S+K+ L+I+R + EK L + +EN+ KE
Sbjct: 2055 FSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQD 2114
Query: 791 --KKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHG---ISKDKRDYLWTSAKN 845
++ ++ L + Y +L + + + R + + + +D + TS KN
Sbjct: 2115 NHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKN 2174
Query: 846 TLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKK 880
L+ LP+ + + L++ ENL +E K+
Sbjct: 2175 -LNQFLPE---LPADLEAILERNENLEGELESLKE 2205
Score = 93.6 bits (231), Expect = 8e-19
Identities = 140/597 (23%), Positives = 269/597 (45%), Gaps = 79/597 (13%)
Query: 218 IEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITE 277
++K+ A ++L + + RL++ KL+++ ++ ++ K+EI K+K++ L I I
Sbjct: 483 LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS 542
Query: 278 KENKMKDLTFLLEESRDKVNQLEEKTKLQSE---NLKQSIEKQHHLTKELEDIKVSL-QR 333
++K + + + K QL+ K + L + + + T+E++D++ L +
Sbjct: 543 LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEG 602
Query: 334 SVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRT 393
++ +AL++DL+ I L E T ++ +A+ + E ET L+ L
Sbjct: 603 QIAANEALKKDLE---GVISGLQEYLGTIKGQATQAQNECRKLRDEKETL---LQRLTEV 656
Query: 394 EQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQF 453
EQ+R DQL+I+ M+ + N EL EL+ L E+ + N
Sbjct: 657 EQER-----DQLEIVAMDAE--------------NMRKELAELESALQEQHEV---NASL 694
Query: 454 EKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKN 513
++ +L E EL L R+ E + L+ +L +T Q E L+ ELE E+
Sbjct: 695 QQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL---EQSALQAELEKER--- 748
Query: 514 TELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLR 573
L + K ++E QE S++ +LK+ Q+D N +LKQ L++ + L
Sbjct: 749 QALKNALGKAQF-SEEKEQENSELHAKLKHLQDDNN--------LLKQ--QLKDFQNHLN 797
Query: 574 NELE-YVR-EELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTA 631
+ ++ VR EE+ + DE++ KL K N+ + K + +LQ++ + +
Sbjct: 798 HVVDGLVRPEEVAARVDELRRKL-KLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW 856
Query: 632 ESKQLNVYEIKVNKLELELESAKQKFG--EITDTYQKEIEDK----KISEENLLEEVEKA 685
E + V E K+ + E+ L+ K G E ++ +E + K E ++++E
Sbjct: 857 ERDEAQVRERKLQE-EMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENE 915
Query: 686 KVIADEAVKLQKEI-----------DKRCQHKIAEMVALMEKHKHQYDKIIEE---RDSE 731
E +K +EI D+ + +A++ L +K K + K E+ D E
Sbjct: 916 IHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKE 975
Query: 732 LGLYKSKEQEQSSLRASLEI-----ELSNLKAELLSVKKQLEIEREEKEKLKREAKE 783
L K K S A+ E+ +L +L ++ + ++ E +E E+ R+A +
Sbjct: 976 LKKLK-KAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQ 1031
Score = 92.0 bits (227), Expect = 2e-18
Identities = 142/652 (21%), Positives = 281/652 (43%), Gaps = 106/652 (16%)
Query: 313 SIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAA 372
++ + H+L E+ ++ +Q S ++ EE A+K + E +MEE +
Sbjct: 1314 NVPEHHNLENEVSRLEDIMQHLKSKKR--EERWMRASK------RQSEKEMEELH----- 1360
Query: 373 HSF--VVTEFETTVCSLEELLRTEQQRLEKN---EDQLKILTMELQKKSS---------E 418
H+ ++ E ++ C +EEL RT Q+R ++ + ++ L EL+ + S E
Sbjct: 1361 HNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDE 1420
Query: 419 LEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV 478
+E + K + EL E ++L E E+ L K+ K A E K T+ + L + E
Sbjct: 1421 IECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVE-KFTDAKRSLLQTESDAEE 1479
Query: 479 HDLEIQLTAI--TTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKE----LTQ 532
+ Q TA+ ++Q D K +LE K+K E+ NK+ L++
Sbjct: 1480 LERRAQETAVNLVKADQQLRSLQADAK-DLEQHKIKQEEILKEINKIVAAKDSDFQCLSK 1538
Query: 533 ETSDMTLELKNQQEDINNNKKQEERMLK--------------QIENLQETETQLRNELEY 578
+ +T EL+ Q+DI ++ E+ L+ ++E L+ T + E+
Sbjct: 1539 KKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAV 1598
Query: 579 VREELKQKRDE--------VKCKLDKSE----------ENCNNLRKQVENKNKYIEELQQ 620
+ +L K++E V+ K D E E CN++R+ +EEL
Sbjct: 1599 LDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE----VKSLLEELSF 1654
Query: 621 ENKALKKKGTAESKQLNVYEIKVNKLELELE-------SAKQKFGEITDTYQ---KEIED 670
+ L + + QL + + ++ K E L+ K + I D Q E++
Sbjct: 1655 QKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQG 1714
Query: 671 KKISEENLLEEVEKAKV-IADEAVKLQ--KEIDKRCQHKIAEMVALMEKHKHQYDKIIEE 727
K+ + + E+EK +V + +E ++L+ ++I ++ + +I L+E+ K + +++ E
Sbjct: 1715 LKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAE 1774
Query: 728 RDSELGLYKSKEQEQSSLRASLEI---ELSNLKAELLSVKKQLEIEREEKEKLKREAKEN 784
+ + +E+ L+ +I +L+ K L + ++ ++E+ EKL+ N
Sbjct: 1775 SRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLEL----N 1830
Query: 785 TATLKEKKDKKTQTFLL---ETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWT 841
L+++ D+ + L + + +L K ++ +V ++ K+D L T
Sbjct: 1831 VRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHT 1890
Query: 842 SAKNTL----STPLPKAYT--------VKTPTKPKLQQRENLNIPIEESKKK 881
+ + T L K + + + K QQ + L IEE+K K
Sbjct: 1891 TKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLK 1942
Score = 91.3 bits (225), Expect = 4e-18
Identities = 129/662 (19%), Positives = 290/662 (43%), Gaps = 66/662 (9%)
Query: 141 IEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKY 200
+E + +++ E++ K ++E K+ K N + + L K++C E
Sbjct: 272 VERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCE---ELKSDL 328
Query: 201 EYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKE 260
+ E +Q ++L +K +EL +K+ +E + + EY +
Sbjct: 329 NTKNELLKQKTIELTRACQKQYELEQELAF----------YKIDAKFEPLNYYPSEYAEI 378
Query: 261 INDKEKQVSLLLIQITEKENKMKDLTFLLEESRD-KVNQLEEKTKLQSENLKQSIEKQHH 319
DK S + + K N +++++ ++ ++ ++E +L+++++ ++
Sbjct: 379 --DKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHM--NLRGHTP 434
Query: 320 LTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEES---NKARAAHSFV 376
L +LED + + + + L ++++ A + I + TEE + Q+EE+ K A +
Sbjct: 435 LDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFK-QLEEAIQLKKISEAGKDL 493
Query: 377 VTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEEL 436
+ + + L LR E LE ++ K QK+ +L+ ++K+ + +
Sbjct: 494 LYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHM 553
Query: 437 K-KVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY 495
K + G+++ L NKQ++++ L E++ + +E+ DLE QLT +
Sbjct: 554 KAQKSGKEQQLDIMNKQYQQLESRL----DEILSRIAKETEEIKDLEEQLTEGQIAANEA 609
Query: 496 SKE-----VKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN 550
K+ + L+ L K + T+ + C KL E + L Q +++ E ++Q E +
Sbjct: 610 LKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQE-RDQLEIVAM 668
Query: 551 NKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVEN 610
+ + + L ++E+ + + ++ L+ + +L E++ +L+ + N L++++E
Sbjct: 669 DAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELE- 727
Query: 611 KNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIED 670
K Q E AL+ + LE E ++ K G+ + +KE E+
Sbjct: 728 --KVTRLTQLEQSALQAE-----------------LEKERQALKNALGKAQFSEEKEQEN 768
Query: 671 KKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIE-ERD 729
++ K K + D+ L++++ K Q+ + +V + + + ++ E R
Sbjct: 769 SELHA--------KLKHLQDDNNLLKQQL-KDFQNHLNHVVDGLVRPEEVAARVDELRRK 819
Query: 730 SELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLK 789
+LG + S + +L +E+L+ K ER+E + +R+ +E A +
Sbjct: 820 LKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKW---ERDEAQVRERKLQEEMALQQ 876
Query: 790 EK 791
EK
Sbjct: 877 EK 878
Score = 69.3 bits (168), Expect = 2e-11
Identities = 121/571 (21%), Positives = 237/571 (41%), Gaps = 69/571 (12%)
Query: 102 LSRVYSKLYKEAEKIKKWKVS-TEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSL 160
L + S++ KE E+IK + TE ++ E+ ++ +I ++ + ++ +
Sbjct: 578 LDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQN 637
Query: 161 KLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEK 220
+ + E + L++ + L E A AE +K E E Q ++N ++++
Sbjct: 638 ECRKLRDEKETLLQRLTEVEQERDQL-EIVAMDAENMRKELAELESALQEQHEVNASLQQ 696
Query: 221 M---ITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIN---DKEKQV---SLL 271
++A+E N R +LKE+ EK+ L Q + + +KE+Q +L
Sbjct: 697 TQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALG 756
Query: 272 LIQITE-KENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIE---KQHHLTKELEDI 327
Q +E KE + +L L+ +D N L+++ K +L ++ + + ++++
Sbjct: 757 KAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDEL 816
Query: 328 KVSLQRSV------STQKALEEDLQIATKTICQLTEEKETQMEESN-KARAAHSFVVTEF 380
+ L+ S L + L K ++ + + +E+ + R + +
Sbjct: 817 RRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQ 876
Query: 381 ETTVCSLEELLRTEQQRLE------KNEDQLKILTME-----LQKKSSELEEMTKLTNNK 429
E EE + ++ LE K + + +I ME LQ+ +EE+ LT+ +
Sbjct: 877 EKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQ 936
Query: 430 EVELEELKKVLGEKETLLYENKQFEKIA--EELKGTEQELIGLLQAREKEVHDLEIQLTA 487
E +E EKE +L + ++ EK E+ K EQ + GL +KE+ L+ A
Sbjct: 937 LQEADE------EKERILAQLRELEKKKKLEDAKSQEQ-VFGL----DKELKKLK---KA 982
Query: 488 ITTSEQYYSKEV---KDLKTELENEKLK-NTELTSHCNKLSLENKELTQETSDMT----- 538
+ TS++ + E+ KD L +K N E + +++ Q D+T
Sbjct: 983 VATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE 1042
Query: 539 -------LELKNQQEDINNNKKQ----EERMLKQIENLQETETQLRNELEYVREELKQKR 587
L K +Q + K + +IE L ET + R E+ ++ L
Sbjct: 1043 IELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTG 1102
Query: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEEL 618
+ K + E LR++V +N YI +
Sbjct: 1103 SDNKGGFENVLEEIAELRREVSYQNDYISSM 1133
Score = 67.4 bits (163), Expect = 6e-11
Identities = 142/698 (20%), Positives = 287/698 (41%), Gaps = 118/698 (16%)
Query: 91 LKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQE 150
L+D + + S +R+ S+L+ E EK ++ + E +Q E +Q +KI EA + + +
Sbjct: 439 LEDKEKKISAAQTRL-SELHDEIEKAEQQILRATEEFKQLEEAIQL-KKISEAGKDLLYK 496
Query: 151 -----LQFGNE------KVSLKLEEGIQENKDLIKENNATRHLCNLLKETCAR----SAE 195
LQ N+ + L++E+ QE KE + + L + A+
Sbjct: 497 QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQ 556
Query: 196 KTKKYEYEREETRQVYMDLNNNIEKMITAF-------EELRVQAENSRLEMHFKLKEDYE 248
K+ K E + + + Y L + ++++++ ++L Q ++ + LK+D E
Sbjct: 557 KSGK-EQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLE 615
Query: 249 KIQHLEQEYKKEINDKEKQVSLLLIQIT-EKENKMKDLTFLLEESRDKVNQLEEKTKLQS 307
+ QEY I + Q ++ EKE ++ LT + E+ RD++ E + +
Sbjct: 616 GVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEV-EQERDQL----EIVAMDA 670
Query: 308 ENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQ----IATKTICQLTEEKE--- 360
EN+++ + + +E ++ SLQ++ A E +L+ + QL EE E
Sbjct: 671 ENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVT 730
Query: 361 --TQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNE---------DQLKILT 409
TQ+E+S A + + E + +L + +E++ E +E D +L
Sbjct: 731 RLTQLEQS----ALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLK 786
Query: 410 MELQKKSSELEEMTK-LTNNKEV--ELEELKKVL----GEK----------ETLLYENKQ 452
+L+ + L + L +EV ++EL++ L GE ++L KQ
Sbjct: 787 QQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQ 846
Query: 453 FEKIAEELKGTEQELIGLLQAREKEVHD-LEIQLTAITTSEQYYSK-------------- 497
F +I K E Q RE+++ + + +Q + T ++ + +
Sbjct: 847 FSEILARSKWERDEA----QVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDK 902
Query: 498 -----EVKDLKTELE--NEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINN 550
++ ++ E+ E LK+ E L L+ + +E L +++ + +
Sbjct: 903 RQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLED 962
Query: 551 NKKQEE-----RMLKQIENLQETETQLRN-ELEYVREELK----------QKRDEVKCKL 594
K QE+ + LK+++ T +L EL +++LK Q+R E +
Sbjct: 963 AKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEA 1022
Query: 595 DKSEENCNNLRKQVENKNKYIEELQQ------ENKALKKKGTAESKQLNVYEIKVNKLEL 648
++ + + IE LQ E L+ + T N +++ KL
Sbjct: 1023 ERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNE 1082
Query: 649 ELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAK 686
+E + + + + D K EN+LEE+ + +
Sbjct: 1083 TMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELR 1120
Score = 66.6 bits (161), Expect = 1e-10
Identities = 126/664 (18%), Positives = 284/664 (42%), Gaps = 70/664 (10%)
Query: 172 LIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQ 231
LIK+ +L + + S + KK++Y + V +++ N +I E+L
Sbjct: 87 LIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKL 146
Query: 232 AENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEE 291
+ L + + E I+++ K +N ++ + + + +K ++ +L
Sbjct: 147 LKLRELNLSYNKISKIEGIENMCNLQK--LNLAGNEIEHIPVWLGKKLKSLR----VLNL 200
Query: 292 SRDKVNQLEEKTKLQS----------ENLKQSIEKQHHLTK-ELEDIKVSLQRSVSTQKA 340
+K++ L++ +KL+ EN ++ T L ++ + V+TQ
Sbjct: 201 KGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDR 260
Query: 341 LEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVC---SLEELLRTEQQR 397
E + + + + +L + E +M E+ + ++ + + E + SL+E ++Q
Sbjct: 261 QEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQS 320
Query: 398 LEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEE---LKKVLGEKETLLYENKQFE 454
E+ + L L++K+ EL + K+ ELE+ K+ + E L Y ++
Sbjct: 321 CEELKSDLNTKNELLKQKTIELTRACQ----KQYELEQELAFYKIDAKFEPLNYYPSEYA 376
Query: 455 KIAEELKGTEQELIGLLQ------AREKEVHDLE--IQLTAITTSEQYYSKEVK-----D 501
+I + E IG + A E + D +Q+ + EQ + +
Sbjct: 377 EI--DKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTP 434
Query: 502 LKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQE---ERM 558
L T+LE+++ K + + ++L E ++ Q+ T E K +E I K E + +
Sbjct: 435 LDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLL 494
Query: 559 LKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEEL 618
KQ+ + +LR E + ++++++ E+ K ++ +L+ +++ ++
Sbjct: 495 YKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGK----QKEIKDLQIAIDS----LDSK 546
Query: 619 QQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFG----EITDTYQKEIEDKKIS 674
++ +K + + + +QL++ + +LE L+ + EI D ++ E + +
Sbjct: 547 DPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAA 606
Query: 675 EENLLEEVEKA--------KVIADEAVKLQKEIDKRCQHK--IAEMVALMEKHKHQYDKI 724
E L +++E I +A + Q E K K + + + +E+ + Q + +
Sbjct: 607 NEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIV 666
Query: 725 IEERDS---ELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREA 781
+ ++ EL +S QEQ + ASL+ +L A ++ +L + E +LK E
Sbjct: 667 AMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEEL 726
Query: 782 KENT 785
++ T
Sbjct: 727 EKVT 730
Score = 59.3 bits (142), Expect = 2e-08
Identities = 80/318 (25%), Positives = 144/318 (45%), Gaps = 31/318 (9%)
Query: 519 HCN---KLSLENKELTQETSDMTLELKNQQED-INNNKKQEERMLKQIENLQETETQLRN 574
HCN +LEN+ E L+ K ++E + +K+Q E+ ++++ + + Q +
Sbjct: 1312 HCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKK 1371
Query: 575 ELEYVREELK---QKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTA 631
LE EEL QKR + K +D + E+ ++E K+ E++ E + ++K
Sbjct: 1372 SLECEVEELHRTVQKRQQQKDFIDGNVESLMT-ELEIEKSLKHHEDIVDEIECIEKTLLK 1430
Query: 632 ESKQLNVYEIKVNKLELELESAKQK----FGEITDTYQKEIEDKKISE--ENLLEEVEKA 685
+L + + + E EL K+K + TD + ++ + +E E +E
Sbjct: 1431 RRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVN 1490
Query: 686 KVIADEAVK-LQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELG-LYKSKE---Q 740
V AD+ ++ LQ + QHKI + L E +KI+ +DS+ L K KE +
Sbjct: 1491 LVKADQQLRSLQADAKDLEQHKIKQEEILKE-----INKIVAAKDSDFQCLSKKKEKLTE 1545
Query: 741 EQSSLRASLEIELSNLKAELLSVKKQ---LEIEREEKEKLKREA----KENTATLKEKKD 793
E L+ +E+ N L +K+ L+ +R E EKLK + +E ++
Sbjct: 1546 ELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGH 1605
Query: 794 KKTQTFLLETPEIYWKLD 811
KK + LL+ + K D
Sbjct: 1606 KKEELHLLQGSMVQAKAD 1623
Score = 50.4 bits (119), Expect = 8e-06
Identities = 98/457 (21%), Positives = 191/457 (41%), Gaps = 78/457 (17%)
Query: 92 KDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQEL 151
+D L L + S+ E +K + + + +L+ +++++EN+ + Q Q L
Sbjct: 1894 QDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRL 1953
Query: 152 QFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVY 211
Q E KLE +K +KE ++++ E+E T Q
Sbjct: 1954 QKERESEESKLE----TSKVTLKE----------------------QQHQLEKELTDQ-K 1986
Query: 212 MDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQV--- 268
L+ + K++ A E +R E R E ++ + K++++++E+Q+
Sbjct: 1987 SKLDQVLSKVLAAEERVRTLQEEERW---------CESLEKTLSQTKRQLSEREQQLVEK 2037
Query: 269 --SLLLIQITEKENKMKDLTFL-------LEESRDKVNQLEEKTKLQSENLKQSIEKQHH 319
LL +Q E ++ D + L +++ +V L+E K+Q L++++ +Q
Sbjct: 2038 SGELLALQ-KEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQ 2096
Query: 320 ----LTKELEDIKVSLQ----RSVSTQKALEEDLQIATKTICQLTEEKE---TQMEESNK 368
+ KE+ I++ Q R+ K L + T+ Q+ +K+ QME S+
Sbjct: 2097 ENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEISDA 2156
Query: 369 ARAAHSFVVTEFETTVCSLEEL-------LRTEQQRLEKNEDQLKILTMELQKKSSELEE 421
R S V E T++ +L + L +R E E +L+ L L +E
Sbjct: 2157 MRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPF 2216
Query: 422 MTKLTNNKEVEL-------EELKKVLGEKETLLYENKQ--FEKIAEELKGTEQELIGLLQ 472
KL N +V + E L++ L +E L + K AE L +++ G L
Sbjct: 2217 EEKL-NFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLH 2275
Query: 473 AREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENE 509
+ ++V L +L T+++ S + L++ L +
Sbjct: 2276 SLRRQVDALG-ELVTSTSADSASSPSLSQLESSLTED 2311
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 126 bits (317), Expect = 9e-29
Identities = 179/768 (23%), Positives = 336/768 (43%), Gaps = 96/768 (12%)
Query: 80 VGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRK 139
+ N E LK + E +S + SK+ E + + + ++++ +++++E +
Sbjct: 1075 IENEKQQLDEKLKKKEFE----ISNLQSKIEDE----QALGIQLQKKIKELQARIEELEE 1126
Query: 140 IIEAQR-------KAIQELQFGNEKVSLKLEEG-------IQENKDLIKE-NNATRHLCN 184
IEA+R K +L E++S +LEE I+ NK E R L
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186
Query: 185 LLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAEN--SRLEMHFK 242
+ A +A KK+ E + +L +K+ E++++ ++ S +E K
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK 1246
Query: 243 LKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK 302
K + EK+ ++ E+ KE++ L+ +T + +++ ES + QL+EK
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQT------ESGEFSRQLDEK 1300
Query: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
L S Q + T+++E++K L+ + + AL LQ +++ C L E Q
Sbjct: 1301 EALVS----QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ-SSRHDCDLLRE---Q 1352
Query: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQ-QRLEKNEDQLKILTMELQKKSSELE- 420
EE +++A +++ T V T+ QR E+ E+ K L LQ +E
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEA 1412
Query: 421 --------EMTKLTNNKEVE--LEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGL 470
E TK EVE + ++++ L + + F+KI E K +E
Sbjct: 1413 VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1472
Query: 471 LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKEL 530
L+A +KE L +L I + Y + + L+T L ENK L
Sbjct: 1473 LEASQKEARSLGTELFKIKNA---YEESLDQLET------------------LKRENKNL 1511
Query: 531 TQETSDMTLELK---NQQEDINNNKKQEERMLKQIE-NLQETETQLRNE---LEYVREEL 583
QE SD+T ++ + ++ KKQ E+ +++ L+E E L +E + ++ EL
Sbjct: 1512 QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLEL 1571
Query: 584 KQKRDEVKCKLDKSEENCNNLRKQ----VENKNKYIE-ELQQENKA--LKKKGTAESKQL 636
Q + EV K+ + +E + L++ VE+ ++ E++ N A LKKK + ++
Sbjct: 1572 NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 637 NVYEIKVNKLELE-LESAKQKFGEITDTYQKEIEDKKISEENLLEEV----EKAKVIADE 691
+ N++ E L + + G + DT Q ++D S+E+L E++ +A ++ E
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDT-QIHLDDALRSQEDLKEQLAMVERRANLLQAE 1690
Query: 692 AVKLQKEIDK-RCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLE 750
+L+ +++ KIAE L + Q + + S + K E + S ++ +E
Sbjct: 1691 IEELRATLEQTERSRKIAEQELLDASERVQL--LHTQNTSLINTKKKLETDISQMQGEME 1748
Query: 751 IELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQT 798
L + KK + E+LK+E ++ +A L+ K QT
Sbjct: 1749 DILQEARNAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMKKNMEQT 1795
Score = 125 bits (313), Expect = 3e-28
Identities = 201/890 (22%), Positives = 400/890 (44%), Gaps = 119/890 (13%)
Query: 89 EGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTE---AELRQKESKLQENRKIIEAQR 145
EGL D++ E + L + +L + +++ + E AEL K+ KL++ + +
Sbjct: 902 EGLADAE-ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL---K 957
Query: 146 KAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYERE 205
K I +L+ KV + E+ ENK N T + L ET A+ ++ K + +
Sbjct: 958 KDIDDLELTLAKV--EKEKHATENK----VKNLTEEMAGL-DETIAKLTKEKKALQEAHQ 1010
Query: 206 ETR---QVYMDLNNNIEKMITAFEE--------------LRVQAENSRLEMHFKLKEDYE 248
+T Q D N + K E+ LR+ E ++ ++ LK E
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1070
Query: 249 KIQHLE---QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKL 305
I +E Q+ +++ KE ++S L +I +++ L ++E + ++ +LEE+ +
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 306 QSENLKQSIEKQHHLTKELEDIKVSLQRS-------VSTQKALEEDLQIATKTICQLTEE 358
+ + ++ +++ L++ELE+I L+ + + K E + Q + + E
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL-----E 1185
Query: 359 KETQMEESNKA--RAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKS 416
+ T E+ A R H+ V E + +L+ + +Q+LEK + ++K ME+ +
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRV----KQKLEKEKSEMK---MEIDDLA 1238
Query: 417 SELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREK 476
S +E ++K N E L+ L E L + ++ +++ +L L +
Sbjct: 1239 SNVETVSKAKGNLEKMCRTLEDQLSE---LKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 477 EVHDLEIQLTAITTSEQYYSKEVKDLKTELENE-KLKNT-----ELTSH-CNKLSLENKE 529
++ + E ++ ++ +Q +++++++LK +LE E K KN + + H C+ L + +E
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEE 1355
Query: 530 LTQETSDMTLELKNQQEDINN-NKKQEERMLKQIENLQETETQLRNELEYVREELKQKRD 588
+ +++ L ++ K E +++ E L+E + +L L+ E + +
Sbjct: 1356 EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHV----E 1411
Query: 589 EVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLEL 648
V K E+ L+ +VE+ +E AL KK K L ++ K +
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA 1471
Query: 649 ELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIA 708
ELE A QK T E+ K + E L+++E K E LQ+EI +
Sbjct: 1472 ELE-ASQKEARSLGT---ELFKIKNAYEESLDQLETLK---RENKNLQQEIS-----DLT 1519
Query: 709 EMVALMEKHKHQYDKIIEERDSE-LGLYKSKEQEQSSLR------ASLEIELSNLKAELL 761
E +A K H+ +KI ++ + E L + E+ ++SL +++EL+ +K+E
Sbjct: 1520 EQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE-- 1577
Query: 762 SVKKQLEIEREEKEKLKR------EAKENT--ATLKEKKD----KKTQTFLLETPEIYWK 809
V +++ + EE ++LKR E+ ++T A ++ + D KK L EI +
Sbjct: 1578 -VDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI--Q 1634
Query: 810 LDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQR- 868
L+ + RN+ + GI KD + +L + ++ K + L Q
Sbjct: 1635 LNHANRMAAEALRNYRNT-QGILKDTQIHLDDALRSQEDL---KEQLAMVERRANLLQAE 1690
Query: 869 -ENLNIPIEESKKKRKMAFEFDINSDSSETTDLL-----SMVSEEETLKT 912
E L +E++++ RK+A + + D+SE LL S+++ ++ L+T
Sbjct: 1691 IEELRATLEQTERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLET 1738
Score = 103 bits (257), Expect = 8e-22
Identities = 168/814 (20%), Positives = 344/814 (42%), Gaps = 129/814 (15%)
Query: 150 ELQFGNEKVSLK-----LEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYER 204
+ +FG+ KV K L E ++++K L L+ T AR + EY+R
Sbjct: 761 QYKFGHTKVFFKAGLLGLLEEMRDDK-----------LAQLITRTQARCRGFLARVEYQR 809
Query: 205 E-ETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHL--EQEYKKEI 261
E R+ + NI + H+ + + KI+ L E +KE+
Sbjct: 810 MVERREAIFCIQYNIRSFMNV--------------KHWPWMKLFFKIKPLLKSAETEKEM 855
Query: 262 NDKEKQVSLLLIQITEKENKMKDL----TFLLEESRDKVNQLEE---------------- 301
+++ + ++ + E K K+L LL+E D Q++
Sbjct: 856 ATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLI 915
Query: 302 KTKLQSE-NLKQSIEKQH---------------------HLTKELEDIKVSLQRSVSTQK 339
KTK+Q E +K+ E+ L K+++D++++L + +
Sbjct: 916 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 975
Query: 340 ALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL----LRTEQ 395
A E ++ T+ + L E +E + AH + + + + L ++ EQ
Sbjct: 976 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1035
Query: 396 Q--RLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQF 453
Q LE + +Q K L M+L++ +LE KL +++E K+ L EK + K+F
Sbjct: 1036 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK----LKKKEF 1091
Query: 454 EKIAEELKGTEQELIGL-LQAREKE----VHDLEIQLTAITTSEQYYSKEVKDLKTELEN 508
E + K +++ +G+ LQ + KE + +LE ++ A S K+ DL ELE
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 509 EKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQET 568
+ E + NK+ E M +L ++ + + K +++ E
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEATAATLRKKHADSVAEL 1209
Query: 569 ETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKK 628
Q+ N L+ V+++L++++ E+K ++D N + K N K L+ + LK K
Sbjct: 1210 GEQIDN-LQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Query: 629 GTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAK-V 687
E +Q + ++ + L+ ES + + +++++K E L+ ++ + K
Sbjct: 1269 --EEEQQRLINDLTAQRGRLQTESGE---------FSRQLDEK----EALVSQLSRGKQA 1313
Query: 688 IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSL-R 746
+ +L++++++ + K A + ++ +H D + E+ + E +SK + Q +L +
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNA-LAHALQSSRHDCDLLREQYEEE---QESKAELQRALSK 1369
Query: 747 ASLEIELSNLKAELLSVKKQLEIEREEKEKLKR--EAKENTATLKEK---KDKKTQTFLL 801
A+ E+ K E ++++ E+E +K+ +R A+E+ + K +K Q
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429
Query: 802 ETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAK--------NTLSTPLPK 853
E ++ ++ + + + D +++ K+ T A+ +L T L K
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFK 1489
Query: 854 AYTVKTPTKPKLQ--QRENLNIPIEESKKKRKMA 885
+ +L+ +REN N+ E S ++A
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523
Score = 103 bits (257), Expect = 8e-22
Identities = 137/654 (20%), Positives = 272/654 (41%), Gaps = 58/654 (8%)
Query: 79 QVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENR 138
Q DC + + E+ L R SK E + +W+ E + Q+ +L+E
Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTE---VAQWRTKYETDAIQRTEELEE-- 1394
Query: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
A++K Q LQ E V + K + N L ++ T A A K
Sbjct: 1395 ----AKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK 1450
Query: 199 KYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK 258
K + ++ + E+ E + +A + E+ FK+K YE+ + K
Sbjct: 1451 K----QRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL-FKIKNAYEESLDQLETLK 1505
Query: 259 KEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQH 318
+E + ++++S L QI E ++ +L E+ + +V Q EK +LQ+
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHEL----EKIKKQVEQ--EKCELQAA---------- 1549
Query: 319 HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
LE+ + SL+ ++ +L + + EK+ EE ++ + H +V
Sbjct: 1550 -----LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD---EEIDQLKRNHIRIVE 1601
Query: 379 EFETTVCSLEELLRTEQQRLEKN-EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK 437
++T+ E R + RL+K E L + ++L + E + N + L++ +
Sbjct: 1602 SMQSTL-DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQ 1660
Query: 438 KVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSK 497
L + + E + E+L E+ LLQA E+ +L L S + +
Sbjct: 1661 IHLDDAL------RSQEDLKEQLAMVERRA-NLLQA---EIEELRATLEQTERSRKIAEQ 1710
Query: 498 EVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEER 557
E+ D ++ +NT L + KL + ++ E D+ E +N +E
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 558 MLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC-NNLRKQVENKNKYIE 616
M ++++ Q+T L E +++ ++Q +++ +LD++E+ +KQ++ +
Sbjct: 1771 MAEELKKEQDTSAHL----ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826
Query: 617 ELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEE 676
EL+ E ++ +K+ K L +E +V +L + E ++ + D K K +
Sbjct: 1827 ELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKR 1886
Query: 677 NLLEEVEKAKVIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQYDKIIEE 727
E E++ + KLQ E+ ++R +++ L K + + K+I E
Sbjct: 1887 QAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISE 1940
Score = 85.1 bits (209), Expect = 3e-16
Identities = 124/533 (23%), Positives = 231/533 (43%), Gaps = 82/533 (15%)
Query: 436 LKKVLGEKETLLYENKQFEKIAEEL-------KGTEQELIGLLQAREKEVHDLEIQLTA- 487
LK EKE + ++F+KI +EL K E++++ LL KE +DL++Q+ A
Sbjct: 846 LKSAETEKEMATMK-EEFQKIKDELAKSEAKRKELEEKMVTLL----KEKNDLQLQVQAE 900
Query: 488 --------------ITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQE 533
I T Q +K +K++ E+E+ N ELT+ KL E EL ++
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAK-IKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 959
Query: 534 TSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCK 593
D+ L L +++ + + + + + +++ L ET +L E + ++E +Q D+++ +
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 594 LD----------KSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKV 643
D K E+ ++L +E + K +L++ + K +G + Q ++ +I+
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKR--KLEGDLKLAQESIMDIEN 1077
Query: 644 NKLELELESAKQKFGEITDTYQKEIED---------KKISE-----ENLLEEVEKAKVIA 689
K +L+ E K+K EI++ Q +IED KKI E E L EE+E +
Sbjct: 1078 EKQQLD-EKLKKKEFEISN-LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135
Query: 690 DEAVKLQKEIDKRCQH----------KIAEMVALMEKHKHQYDKIIEERDSELGLYKSKE 739
+A K + ++ + + + + + +K + ++ K+ + + +++
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195
Query: 740 QEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKK---DKKT 796
A EL L VK++LE E+ E + + N T+ + K +K
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255
Query: 797 QTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDY-LWTSAKNTLSTPLPKAY 855
+T + E L SK Q + + T+ + + ++ K L + L +
Sbjct: 1256 RTLEDQLSE----LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 856 TVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSMVSEEE 908
T QQ E L +EE + K K A + S S DLL EEE
Sbjct: 1312 QAFT------QQIEELKRQLEE-EIKAKNALAHALQS-SRHDCDLLREQYEEE 1356
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 126 bits (317), Expect = 9e-29
Identities = 179/768 (23%), Positives = 336/768 (43%), Gaps = 96/768 (12%)
Query: 80 VGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRK 139
+ N E LK + E +S + SK+ E + + + ++++ +++++E +
Sbjct: 1075 IENEKQQLDEKLKKKEFE----ISNLQSKIEDE----QALGIQLQKKIKELQARIEELEE 1126
Query: 140 IIEAQR-------KAIQELQFGNEKVSLKLEEG-------IQENKDLIKE-NNATRHLCN 184
IEA+R K +L E++S +LEE I+ NK E R L
Sbjct: 1127 EIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186
Query: 185 LLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAEN--SRLEMHFK 242
+ A +A KK+ E + +L +K+ E++++ ++ S +E K
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK 1246
Query: 243 LKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK 302
K + EK+ ++ E+ KE++ L+ +T + +++ ES + QL+EK
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQT------ESGEFSRQLDEK 1300
Query: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ 362
L S Q + T+++E++K L+ + + AL LQ +++ C L E Q
Sbjct: 1301 EALVS----QLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ-SSRHDCDLLRE---Q 1352
Query: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQ-QRLEKNEDQLKILTMELQKKSSELE- 420
EE +++A +++ T V T+ QR E+ E+ K L LQ +E
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEA 1412
Query: 421 --------EMTKLTNNKEVE--LEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGL 470
E TK EVE + ++++ L + + F+KI E K +E
Sbjct: 1413 VNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAE 1472
Query: 471 LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKEL 530
L+A +KE L +L I + Y + + L+T L ENK L
Sbjct: 1473 LEASQKEARSLGTELFKIKNA---YEESLDQLET------------------LKRENKNL 1511
Query: 531 TQETSDMTLELK---NQQEDINNNKKQEERMLKQIE-NLQETETQLRNE---LEYVREEL 583
QE SD+T ++ + ++ KKQ E+ +++ L+E E L +E + ++ EL
Sbjct: 1512 QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLEL 1571
Query: 584 KQKRDEVKCKLDKSEENCNNLRKQ----VENKNKYIE-ELQQENKA--LKKKGTAESKQL 636
Q + EV K+ + +E + L++ VE+ ++ E++ N A LKKK + ++
Sbjct: 1572 NQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEM 1631
Query: 637 NVYEIKVNKLELE-LESAKQKFGEITDTYQKEIEDKKISEENLLEEV----EKAKVIADE 691
+ N++ E L + + G + DT Q ++D S+E+L E++ +A ++ E
Sbjct: 1632 EIQLNHANRMAAEALRNYRNTQGILKDT-QIHLDDALRSQEDLKEQLAMVERRANLLQAE 1690
Query: 692 AVKLQKEIDK-RCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLE 750
+L+ +++ KIAE L + Q + + S + K E + S ++ +E
Sbjct: 1691 IEELRATLEQTERSRKIAEQELLDASERVQL--LHTQNTSLINTKKKLETDISQMQGEME 1748
Query: 751 IELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQT 798
L + KK + E+LK+E ++ +A L+ K QT
Sbjct: 1749 DILQEARNAEEKAKKAITDAAMMAEELKKE-QDTSAHLERMKKNMEQT 1795
Score = 125 bits (313), Expect = 3e-28
Identities = 201/890 (22%), Positives = 400/890 (44%), Gaps = 119/890 (13%)
Query: 89 EGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTE---AELRQKESKLQENRKIIEAQR 145
EGL D++ E + L + +L + +++ + E AEL K+ KL++ + +
Sbjct: 902 EGLADAE-ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL---K 957
Query: 146 KAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYERE 205
K I +L+ KV + E+ ENK N T + L ET A+ ++ K + +
Sbjct: 958 KDIDDLELTLAKV--EKEKHATENK----VKNLTEEMAGL-DETIAKLTKEKKALQEAHQ 1010
Query: 206 ETR---QVYMDLNNNIEKMITAFEE--------------LRVQAENSRLEMHFKLKEDYE 248
+T Q D N + K E+ LR+ E ++ ++ LK E
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQE 1070
Query: 249 KIQHLE---QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKL 305
I +E Q+ +++ KE ++S L +I +++ L ++E + ++ +LEE+ +
Sbjct: 1071 SIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEA 1130
Query: 306 QSENLKQSIEKQHHLTKELEDIKVSLQRS-------VSTQKALEEDLQIATKTICQLTEE 358
+ + ++ +++ L++ELE+I L+ + + K E + Q + + E
Sbjct: 1131 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDL-----E 1185
Query: 359 KETQMEESNKA--RAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKS 416
+ T E+ A R H+ V E + +L+ + +Q+LEK + ++K ME+ +
Sbjct: 1186 EATLQHEATAATLRKKHADSVAELGEQIDNLQRV----KQKLEKEKSEMK---MEIDDLA 1238
Query: 417 SELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREK 476
S +E ++K N E L+ L E L + ++ +++ +L L +
Sbjct: 1239 SNVETVSKAKGNLEKMCRTLEDQLSE---LKSKEEEQQRLINDLTAQRGRLQTESGEFSR 1295
Query: 477 EVHDLEIQLTAITTSEQYYSKEVKDLKTELENE-KLKNT-----ELTSH-CNKLSLENKE 529
++ + E ++ ++ +Q +++++++LK +LE E K KN + + H C+ L + +E
Sbjct: 1296 QLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEE 1355
Query: 530 LTQETSDMTLELKNQQEDINN-NKKQEERMLKQIENLQETETQLRNELEYVREELKQKRD 588
+ +++ L ++ K E +++ E L+E + +L L+ E + +
Sbjct: 1356 EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHV----E 1411
Query: 589 EVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLEL 648
V K E+ L+ +VE+ +E AL KK K L ++ K +
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA 1471
Query: 649 ELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIA 708
ELE A QK T E+ K + E L+++E K E LQ+EI +
Sbjct: 1472 ELE-ASQKEARSLGT---ELFKIKNAYEESLDQLETLK---RENKNLQQEIS-----DLT 1519
Query: 709 EMVALMEKHKHQYDKIIEERDSE-LGLYKSKEQEQSSLR------ASLEIELSNLKAELL 761
E +A K H+ +KI ++ + E L + E+ ++SL +++EL+ +K+E
Sbjct: 1520 EQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSE-- 1577
Query: 762 SVKKQLEIEREEKEKLKR------EAKENT--ATLKEKKD----KKTQTFLLETPEIYWK 809
V +++ + EE ++LKR E+ ++T A ++ + D KK L EI +
Sbjct: 1578 -VDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI--Q 1634
Query: 810 LDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQR- 868
L+ + RN+ + GI KD + +L + ++ K + L Q
Sbjct: 1635 LNHANRMAAEALRNYRNT-QGILKDTQIHLDDALRSQEDL---KEQLAMVERRANLLQAE 1690
Query: 869 -ENLNIPIEESKKKRKMAFEFDINSDSSETTDLL-----SMVSEEETLKT 912
E L +E++++ RK+A + + D+SE LL S+++ ++ L+T
Sbjct: 1691 IEELRATLEQTERSRKIAEQELL--DASERVQLLHTQNTSLINTKKKLET 1738
Score = 103 bits (257), Expect = 8e-22
Identities = 168/814 (20%), Positives = 344/814 (42%), Gaps = 129/814 (15%)
Query: 150 ELQFGNEKVSLK-----LEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYER 204
+ +FG+ KV K L E ++++K L L+ T AR + EY+R
Sbjct: 761 QYKFGHTKVFFKAGLLGLLEEMRDDK-----------LAQLITRTQARCRGFLARVEYQR 809
Query: 205 E-ETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHL--EQEYKKEI 261
E R+ + NI + H+ + + KI+ L E +KE+
Sbjct: 810 MVERREAIFCIQYNIRSFMNV--------------KHWPWMKLFFKIKPLLKSAETEKEM 855
Query: 262 NDKEKQVSLLLIQITEKENKMKDL----TFLLEESRDKVNQLEE---------------- 301
+++ + ++ + E K K+L LL+E D Q++
Sbjct: 856 ATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLI 915
Query: 302 KTKLQSE-NLKQSIEKQH---------------------HLTKELEDIKVSLQRSVSTQK 339
KTK+Q E +K+ E+ L K+++D++++L + +
Sbjct: 916 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 975
Query: 340 ALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEEL----LRTEQ 395
A E ++ T+ + L E +E + AH + + + + L ++ EQ
Sbjct: 976 ATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1035
Query: 396 Q--RLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQF 453
Q LE + +Q K L M+L++ +LE KL +++E K+ L EK + K+F
Sbjct: 1036 QVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK----LKKKEF 1091
Query: 454 EKIAEELKGTEQELIGL-LQAREKE----VHDLEIQLTAITTSEQYYSKEVKDLKTELEN 508
E + K +++ +G+ LQ + KE + +LE ++ A S K+ DL ELE
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 509 EKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQET 568
+ E + NK+ E M +L ++ + + K +++ E
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDL--EEATLQHEATAATLRKKHADSVAEL 1209
Query: 569 ETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKK 628
Q+ N L+ V+++L++++ E+K ++D N + K N K L+ + LK K
Sbjct: 1210 GEQIDN-LQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Query: 629 GTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAK-V 687
E +Q + ++ + L+ ES + + +++++K E L+ ++ + K
Sbjct: 1269 --EEEQQRLINDLTAQRGRLQTESGE---------FSRQLDEK----EALVSQLSRGKQA 1313
Query: 688 IADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSL-R 746
+ +L++++++ + K A + ++ +H D + E+ + E +SK + Q +L +
Sbjct: 1314 FTQQIEELKRQLEEEIKAKNA-LAHALQSSRHDCDLLREQYEEE---QESKAELQRALSK 1369
Query: 747 ASLEIELSNLKAELLSVKKQLEIEREEKEKLKR--EAKENTATLKEK---KDKKTQTFLL 801
A+ E+ K E ++++ E+E +K+ +R A+E+ + K +K Q
Sbjct: 1370 ANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429
Query: 802 ETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAK--------NTLSTPLPK 853
E ++ ++ + + + D +++ K+ T A+ +L T L K
Sbjct: 1430 EVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFK 1489
Query: 854 AYTVKTPTKPKLQ--QRENLNIPIEESKKKRKMA 885
+ +L+ +REN N+ E S ++A
Sbjct: 1490 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1523
Score = 103 bits (257), Expect = 8e-22
Identities = 137/654 (20%), Positives = 272/654 (41%), Gaps = 58/654 (8%)
Query: 79 QVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENR 138
Q DC + + E+ L R SK E + +W+ E + Q+ +L+E
Sbjct: 1340 QSSRHDCDLLREQYEEEQESKAELQRALSKANTE---VAQWRTKYETDAIQRTEELEE-- 1394
Query: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
A++K Q LQ E V + K + N L ++ T A A K
Sbjct: 1395 ----AKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDK 1450
Query: 199 KYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK 258
K + ++ + E+ E + +A + E+ FK+K YE+ + K
Sbjct: 1451 K----QRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL-FKIKNAYEESLDQLETLK 1505
Query: 259 KEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQH 318
+E + ++++S L QI E ++ +L E+ + +V Q EK +LQ+
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHEL----EKIKKQVEQ--EKCELQAA---------- 1549
Query: 319 HLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
LE+ + SL+ ++ +L + + EK+ EE ++ + H +V
Sbjct: 1550 -----LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD---EEIDQLKRNHIRIVE 1601
Query: 379 EFETTVCSLEELLRTEQQRLEKN-EDQLKILTMELQKKSSELEEMTKLTNNKEVELEELK 437
++T+ E R + RL+K E L + ++L + E + N + L++ +
Sbjct: 1602 SMQSTL-DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQ 1660
Query: 438 KVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSK 497
L + + E + E+L E+ LLQA E+ +L L S + +
Sbjct: 1661 IHLDDAL------RSQEDLKEQLAMVERRA-NLLQA---EIEELRATLEQTERSRKIAEQ 1710
Query: 498 EVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEER 557
E+ D ++ +NT L + KL + ++ E D+ E +N +E
Sbjct: 1711 ELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAM 1770
Query: 558 MLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC-NNLRKQVENKNKYIE 616
M ++++ Q+T L E +++ ++Q +++ +LD++E+ +KQ++ +
Sbjct: 1771 MAEELKKEQDTSAHL----ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826
Query: 617 ELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEE 676
EL+ E ++ +K+ K L +E +V +L + E ++ + D K K +
Sbjct: 1827 ELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKR 1886
Query: 677 NLLEEVEKAKVIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQYDKIIEE 727
E E++ + KLQ E+ ++R +++ L K + + K+I E
Sbjct: 1887 QAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKVISE 1940
Score = 85.1 bits (209), Expect = 3e-16
Identities = 124/533 (23%), Positives = 231/533 (43%), Gaps = 82/533 (15%)
Query: 436 LKKVLGEKETLLYENKQFEKIAEEL-------KGTEQELIGLLQAREKEVHDLEIQLTA- 487
LK EKE + ++F+KI +EL K E++++ LL KE +DL++Q+ A
Sbjct: 846 LKSAETEKEMATMK-EEFQKIKDELAKSEAKRKELEEKMVTLL----KEKNDLQLQVQAE 900
Query: 488 --------------ITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQE 533
I T Q +K +K++ E+E+ N ELT+ KL E EL ++
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAK-IKEVTERAEDEEEINAELTAKKRKLEDECSELKKD 959
Query: 534 TSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCK 593
D+ L L +++ + + + + + +++ L ET +L E + ++E +Q D+++ +
Sbjct: 960 IDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE 1019
Query: 594 LD----------KSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKV 643
D K E+ ++L +E + K +L++ + K +G + Q ++ +I+
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKR--KLEGDLKLAQESIMDIEN 1077
Query: 644 NKLELELESAKQKFGEITDTYQKEIED---------KKISE-----ENLLEEVEKAKVIA 689
K +L+ E K+K EI++ Q +IED KKI E E L EE+E +
Sbjct: 1078 EKQQLD-EKLKKKEFEISN-LQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135
Query: 690 DEAVKLQKEIDKRCQH----------KIAEMVALMEKHKHQYDKIIEERDSELGLYKSKE 739
+A K + ++ + + + + + +K + ++ K+ + + +++
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195
Query: 740 QEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKK---DKKT 796
A EL L VK++LE E+ E + + N T+ + K +K
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255
Query: 797 QTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDY-LWTSAKNTLSTPLPKAY 855
+T + E L SK Q + + T+ + + ++ K L + L +
Sbjct: 1256 RTLEDQLSE----LKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGK 1311
Query: 856 TVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSMVSEEE 908
T QQ E L +EE + K K A + S S DLL EEE
Sbjct: 1312 QAFT------QQIEELKRQLEE-EIKAKNALAHALQS-SRHDCDLLREQYEEE 1356
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 126 bits (317), Expect = 9e-29
Identities = 186/793 (23%), Positives = 341/793 (43%), Gaps = 123/793 (15%)
Query: 89 EGLKDSDLENSEGLSRVYSK----LYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQ 144
E +KD +N +++ Y K L E+++ + EAE S L+ N +Q
Sbjct: 618 ESVKD---QNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAE----NSDLKVNMAHRTSQ 670
Query: 145 RKAIQELQFGNEKVSLKLE-EGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYE 203
+ IQE S KLE E ++ L+ A++AE ++ +
Sbjct: 671 FQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEK 730
Query: 204 REETRQVYMDLNNNIEKMITAFEELR---------VQAENSRLEMHFKLKEDYEKIQ--- 251
E+ R + ++N EK+ AFE+ + ++ + RLE + K+ K Q
Sbjct: 731 NEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKT 790
Query: 252 -------------HLEQ----------EYKKEINDKEKQVSLLLIQITEKENKMKDLTFL 288
HLE E KKE K++ + L Q++E+ K++ L
Sbjct: 791 MSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSA 850
Query: 289 LEESRDKV----NQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEED 344
LE ++++ NQLE + + LK+ E+ + L KEL+ SLQ + L+
Sbjct: 851 LEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHT 910
Query: 345 LQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQ----RLEK 400
LQ + + Q T + ++E++ T+ E V LE+ L+ +++ +L K
Sbjct: 911 LQQQQQMLQQETI-RNGELEDTQ----------TKLEKQVSKLEQELQKQRESSAEKLRK 959
Query: 401 NEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLY------ENK--- 451
E++ + E K ++ E+T ++E+++ K+ L + E + ENK
Sbjct: 960 MEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMH 1019
Query: 452 --QFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENE 509
Q + I ++ K ++ ++ EK H E +LT + E+++ EL++
Sbjct: 1020 LSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKST 1079
Query: 510 KLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETE 569
+ EL K L +E D+T EL+ + +I + KKQE +L+ + L+E
Sbjct: 1080 LRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIED-KKQE--LLEMDQALKERN 1136
Query: 570 TQLRNELEYV----------REELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEEL- 618
+L+ V R E++QK +++ L+KSE KQ+E+ N ++
Sbjct: 1137 WELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAK 1196
Query: 619 -------------QQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQ 665
+QE LKK+ E Q + E++ E E A Q + E D Q
Sbjct: 1197 EQLREKEFIMLQNEQEISQLKKE--IERTQQRMKEMESVMKEQEQYIATQ-YKEAIDLGQ 1253
Query: 666 KEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKII 725
E+ + +N E+ +A+ + V+ Q+EI+ R ++ +M L K K + +
Sbjct: 1254 -ELRLTREQVQNSHTELAEAR---HQQVQAQREIE-RLSSELEDMKQL-SKEKDAHGNHL 1307
Query: 726 EERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIE----REEKEKLKREA 781
E ELG K +E + L A ++ E+ L AE+ S+K+ +E +E K K A
Sbjct: 1308 AE---ELGASKVRE---AHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISA 1361
Query: 782 KENTATLKEKKDK 794
+++++ ++
Sbjct: 1362 DSQKSSVQQLNEQ 1374
Score = 107 bits (268), Expect = 4e-23
Identities = 153/704 (21%), Positives = 312/704 (44%), Gaps = 79/704 (11%)
Query: 142 EAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHL--CNLLKETCARSAEKTKK 199
EA + I EL+ K+++K E IQ+ + N ++ L CN +E+ S+ +T+
Sbjct: 553 EANKLVISELRI---KLAIK-EAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEP 608
Query: 200 YEYEREETRQVYMDLNNNI---------EKMITAFEELR-----VQAENSRLEMHFKLK- 244
+ + + D N + ++++T EELR ++AENS L+++ +
Sbjct: 609 VKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRT 668
Query: 245 EDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTK 304
++ IQ +E+ +K S L ++T+K +++ L QLEEK
Sbjct: 669 SQFQLIQ-------EELLEKASNSSKLESEMTKKCSQLLTLE----------KQLEEKIV 711
Query: 305 LQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQ-KALEEDLQIATKTICQLTEEKETQM 363
S ++ E + L ++ E I+ SL+ +++T+ + + + A K + +E E Q+
Sbjct: 712 AYSSIAAKNAELEQELMEKNEKIR-SLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQI 770
Query: 364 EESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT 423
E E E T+ L++ + +Q LE + L E++K++ + +E
Sbjct: 771 ERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 830
Query: 424 KLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEI 483
K N+ E E KV L ++ +L+G +++ L+ + +EV+ L+
Sbjct: 831 KALQNQVSE--ETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQK 888
Query: 484 QLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKN 543
+L S Q S++ L+ L+ ++ + T +L +L ++ S + EL+
Sbjct: 889 ELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQK 948
Query: 544 QQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNN 603
Q+E ++ E + + + + Q EL ++K + D+ K +L K E+ +
Sbjct: 949 QRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMH 1008
Query: 604 LRKQVENKNKYIEE----LQQENKALKKKGTAES-----------------KQLNVYEIK 642
L++ ENK ++ + L Q L+KK A ++ V E +
Sbjct: 1009 LKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETE 1068
Query: 643 VNKLELELESAKQKFGEITDTYQK---EIEDKKISEENLLEEVEKAKVIADEAVKLQKEI 699
+ EL+S ++ E+ D QK +E+K + ++L E+ + K+ ++ + E+
Sbjct: 1069 LQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEM 1128
Query: 700 DKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASL---EIELSNL 756
D+ + + E+ + H D I E E+ EQ+ L +L E+EL
Sbjct: 1129 DQALKERNWELKQRAAQVTH-LDMTIREHRGEM------EQKIIKLEGTLEKSELELKEC 1181
Query: 757 KAELLSVKKQLEIERE---EKEKLKREAKENTATLKEKKDKKTQ 797
++ S+ +L+ +E EKE + + ++ + LK++ ++ Q
Sbjct: 1182 NKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQ 1225
Score = 105 bits (261), Expect = 3e-22
Identities = 158/660 (23%), Positives = 302/660 (45%), Gaps = 102/660 (15%)
Query: 86 HYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEA-ELRQKESKLQENRKIIEAQ 144
H+ E L D L S+G + + EA K + +VS E ++RQ +S L+ ++ +
Sbjct: 803 HHLESL-DRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLH 861
Query: 145 RKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYER 204
+ +L+ EK +L++ +E L KE H L+ET ++ + ++
Sbjct: 862 ---LNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS---LQETSEQNVILQHTLQQQQ 915
Query: 205 EETRQVYM------DLNNNIEKMITAFE-ELRVQAENSRLEMHFKLKEDYEKIQH---LE 254
+ +Q + D +EK ++ E EL+ Q E+S ++ K++E E H L+
Sbjct: 916 QMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLR-KMEEKCESAAHEADLK 974
Query: 255 QEYKKEINDKEKQVSLLLIQITEKENKM-KDLTFLLEESRDKVNQLEEKTKLQSENLKQS 313
++ E+ +QV + + Q E+ +KM K++ L + +K L + + + K
Sbjct: 975 RQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQT-KTE 1033
Query: 314 IEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAH 373
+EK+ + KELE LQ S T+ L E LQ E ET+++ AH
Sbjct: 1034 LEKKTNAVKELE----KLQHSTETE--LTEALQ--------KREVLETELQN------AH 1073
Query: 374 SFVVTEFETTVCSLEEL---LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKE 430
E ++T+ L+EL L+ Q LE+ +K LT EL++ E+E+ K+
Sbjct: 1074 G----ELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIED-------KK 1122
Query: 431 VELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITT 490
EL E+ + L E+ +E KQ L T +E G + E+++ LE L
Sbjct: 1123 QELLEMDQALKERN---WELKQRAAQVTHLDMTIREHRGEM---EQKIIKLEGTLEKSEL 1176
Query: 491 SEQYYSKEVKDLKTELEN--EKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDI 548
+ +K+++ L +L+N E+L+ E + L+N+ QE S + E++ Q+ +
Sbjct: 1177 ELKECNKQIESLNDKLQNAKEQLREKEF------IMLQNE---QEISQLKKEIERTQQRM 1227
Query: 549 NNNKKQEERMLKQIENLQETETQ----LRNELEYVREELKQKRDEVKCKLDKSEENCNNL 604
K+ E ++K+ E T+ + L EL RE+++ E L ++
Sbjct: 1228 ----KEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTE----LAEARHQQVQA 1279
Query: 605 RKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIK-----------VNKLELELESA 653
++++E + +E+++Q +K G +++L +++ + KL E+ES
Sbjct: 1280 QREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESL 1339
Query: 654 KQKFGEITDTYQKE-------IEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHK 706
K+ + ++Q+ + +K S + L E++EKAK+ +EA + ++ Q +
Sbjct: 1340 KEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDR 1399
Score = 103 bits (258), Expect = 6e-22
Identities = 125/572 (21%), Positives = 265/572 (46%), Gaps = 78/572 (13%)
Query: 108 KLYKEAEKIKKWKVSTEAELRQKESKLQENRK-------IIEAQRKAIQELQFGN---EK 157
K K+ +K + + EL+ K LQE + ++ Q++ +Q+ N E
Sbjct: 871 KFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELED 930
Query: 158 VSLKLEEGIQE-NKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNN 216
KLE+ + + ++L K+ ++ ++E C +A +E + RQ ++L
Sbjct: 931 TQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAA-------HEADLKRQKVIELTG 983
Query: 217 NIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQIT 276
++ ++ + + E+ ++ K HL Q I D+ K ++
Sbjct: 984 TARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQ--LDMILDQTKT------ELE 1035
Query: 277 EKENKMKDLTFLLEESRDKVNQLEEK-----TKLQSEN--LKQSIEKQHHLTKELEDIKV 329
+K N +K+L L + ++ + +K T+LQ+ + LK ++ + L L+ ++
Sbjct: 1036 KKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQL 1095
Query: 330 SLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEE 389
SL+ +T K L +L+ I E+K+ ++ E ++A ++ + + V L+
Sbjct: 1096 SLEEKYTTIKDLTAELRECKMEI----EDKKQELLEMDQALKERNWELKQRAAQVTHLDM 1151
Query: 390 LLRTEQQRLEKNEDQLKILTME--LQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLL 447
+R + +E+ KI+ +E L+K EL+E K + +L+ K+ L EKE ++
Sbjct: 1152 TIREHRGEMEQ-----KIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIM 1206
Query: 448 YENKQ-FEKIAEELKGTEQ---ELIGLLQARE-------KEVHDL--EIQLTAITTSEQY 494
+N+Q ++ +E++ T+Q E+ +++ +E KE DL E++LT +
Sbjct: 1207 LQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSH 1266
Query: 495 YS------------KEVKDLKTELENEKLKNTELTSHCNKLSLE-NKELTQET---SDMT 538
+E++ L +ELE+ K + E +H N L+ E +E + M
Sbjct: 1267 TELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQ 1326
Query: 539 LELKNQQEDINNNKKQEE-RMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKS 597
E+K ++ + K+ M+ EN + + ++ V ++L ++ ++ K +L+++
Sbjct: 1327 AEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSV-QQLNEQLEKAKLELEEA 1385
Query: 598 EENCNNLRKQVENKNKYIEELQQENKALKKKG 629
++ +NL +QV+++N+ IE N+AL KG
Sbjct: 1386 QDTVSNLHQQVQDRNEVIE---AANEALLTKG 1414
Score = 88.2 bits (217), Expect = 3e-17
Identities = 164/814 (20%), Positives = 326/814 (40%), Gaps = 121/814 (14%)
Query: 91 LKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQE 150
L DL E S Y E E + S EL+ E LQ + + + +
Sbjct: 111 LPSDDLGEMESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENS 170
Query: 151 LQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLL-------KETCARSAEKTKKYEYE 203
N S KL +Q + + + ++C + K+ + + + E
Sbjct: 171 DYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQE 230
Query: 204 REETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLE--QEYKKEI 261
+ R+ L ++T L + E+ +HF+L + K+ LE Q+ +
Sbjct: 231 IKSLREKLNKLRQQNACLVTQNHSLMTKFES----IHFELTQSRAKVSMLESAQQQAASV 286
Query: 262 NDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSEN---LKQSIEKQH 318
E+Q+ L +++ ++ +++ LE+S+ V + E+ + E LK + +Q
Sbjct: 287 PILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQT 346
Query: 319 HLTKELEDIK-VSLQRSVSTQKALEEDLQIATKTICQLTEEKE------TQMEESNKARA 371
K E + +L + KA ++ + + + ++ E+E T E+ NK
Sbjct: 347 KQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQ 406
Query: 372 AHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEV 431
+ +++ + L+E LR ++ +++L+I+ ++ + ++L E + E
Sbjct: 407 ERCGL---YKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLES 463
Query: 432 ELEELKKVLGEKETLLYENKQ----------------------------FEKIAEEL--- 460
ELE ++L +K +L+ EN++ EKI +L
Sbjct: 464 ELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK 523
Query: 461 ------------------KGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDL 502
E IG +A + + +L I+L E++ L
Sbjct: 524 RELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLA-------IKEAEIQKL 576
Query: 503 KTELENEKLKNTELTSHCNKLSLENKELTQETSDMTL-------ELKNQQEDINNN--KK 553
L +L + +T CN +K + ET + L +K+Q + N +K
Sbjct: 577 HANLTANQLSQSLIT--CNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEK 634
Query: 554 QEERMLKQIENLQETETQLR--------------NELEYVREELKQK---RDEVKCKLDK 596
+ +R++ IE L+ Q+ ++ + ++EEL +K +++ ++ K
Sbjct: 635 ERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTK 694
Query: 597 SEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVN----KLELELES 652
L KQ+E K + +N L+++ +++++ E +N K+ L E
Sbjct: 695 KCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEK 754
Query: 653 AKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVA 712
AK+ E +K+IE E L ++ ++ K LQ++I + QH + +
Sbjct: 755 AKKIHLEQHKEMEKQIER---LEAQLEKKDQQFKEQEKTMSMLQQDIICK-QHHLESLDR 810
Query: 713 LMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIERE 772
L+ + K + K ++D L +++ E++ L+ L K EL+ QLE +E
Sbjct: 811 LLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKE 870
Query: 773 EKEK-LKREAKENTATLKEKKDKKTQTFLLETPE 805
+ EK LK++++E KE K K L ET E
Sbjct: 871 KFEKQLKKKSEEVYCLQKELKIKNHS--LQETSE 902
Score = 77.0 bits (188), Expect = 8e-14
Identities = 90/463 (19%), Positives = 198/463 (42%), Gaps = 49/463 (10%)
Query: 107 SKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGI 166
SK+ KE +K+ + L Q + L + + +E + A++EL+ +L E +
Sbjct: 1000 SKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEAL 1059
Query: 167 QENKDLIKE-NNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAF 225
Q+ + L E NA L + L++ + +K + EE DL + +
Sbjct: 1060 QKREVLETELQNAHGELKSTLRQL-QELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 1118
Query: 226 EELR---VQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKM 282
E+ + ++ + + E +++LK+ ++ HL+ ++ + E+++ L + + E ++
Sbjct: 1119 EDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELEL 1178
Query: 283 KDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALE 342
K+ +E DK+ +E+ + + + Q+ ++ L KE+E + ++ S K E
Sbjct: 1179 KECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQE 1238
Query: 343 EDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNE 402
+ + K L +E E+ + EL Q+++
Sbjct: 1239 QYIATQYKEAIDLGQELRLTREQVQNSHT-----------------ELAEARHQQVQAQR 1281
Query: 403 DQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKG 462
E+++ SSELE+M +L+ K+ L + LG + + E ++ E+K
Sbjct: 1282 --------EIERLSSELEDMKQLSKEKDAHGNHLAEELGASK--VREAHLEARMQAEIKK 1331
Query: 463 TEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNK 522
E+ L KE + +E + + ++ ++K K +++K +L K
Sbjct: 1332 LSAEVESL-----KEAYHME-----MISHQENHAK----WKISADSQKSSVQQLNEQLEK 1377
Query: 523 LSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENL 565
LE +E S++ +++++ E I + E +L + EN+
Sbjct: 1378 AKLELEEAQDTVSNLHQQVQDRNEVI---EAANEALLTKGENV 1417
Score = 48.5 bits (114), Expect = 3e-05
Identities = 95/454 (20%), Positives = 190/454 (41%), Gaps = 48/454 (10%)
Query: 497 KEVKDLKTELENEKLKNTELTSHCNKLSLENK----ELTQETSDMT-LELKNQQ------ 545
+E+K L+ +L + +N L + + L + + ELTQ + ++ LE QQ
Sbjct: 229 QEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPI 288
Query: 546 --EDINNNKKQ---EERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEEN 600
E I N + + ++++L++ EN E ++ E E +E K++ ++K L + +
Sbjct: 289 LEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQ 348
Query: 601 CNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEI 660
+Q EEL + + KKK + +++ E + + E ++ E
Sbjct: 349 GKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQER 408
Query: 661 TDTYQKEIEDKKISEENLLEE----VEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEK 716
Y+ E+E K L EE EK +++A + ++ ++ + Q + +E
Sbjct: 409 CGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQ-----SILKLES 463
Query: 717 HKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEI---ELSNLKAELLSVKK---QLEIE 770
D+I+ ++ S + + + ++ L++ E+ + + EL S++K QL ++
Sbjct: 464 ELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLK 523
Query: 771 REEKEKLKREAKENTATLKEKKDK---KTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSV 827
RE +K ++ K+D+ + L E+ KL K Q + N T+
Sbjct: 524 RELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTAN 583
Query: 828 DHGIS----KDKRDYLWTSAKNTLSTPL---PKAYTVK-----TPTKPKLQQRENLNIPI 875
S D ++ S+ T L A +VK T K ++R+ L I
Sbjct: 584 QLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGI 643
Query: 876 EESKKK--RKMAFEFDINSDSSETTDLLSMVSEE 907
EE + K + A D+ + + T ++ EE
Sbjct: 644 EELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEE 677
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 125 bits (313), Expect = 3e-28
Identities = 155/670 (23%), Positives = 302/670 (45%), Gaps = 103/670 (15%)
Query: 91 LKDSDLENSE--GLSRVYSKLYKEA----EKIKKWKVSTEAE---LRQKESKLQENRKII 141
+K+ D E ++ L S++ KE +I +++ E E R E+++ + +
Sbjct: 464 MKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQL 523
Query: 142 EAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYE 201
E +K Q Q NEK+S +L++ ++E DL++ + T A + +K
Sbjct: 524 EDLKKVSQNSQLANEKLS-QLQKQLEEANDLLRTESDT--------------AVRLRKSH 568
Query: 202 YEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEI 261
E ++ LN +++ E + Q + +DY ++Q + + +++
Sbjct: 569 TEMSKSISQLESLNRELQERNRILENSKSQTD-----------KDYYQLQAILEAERRDR 617
Query: 262 NDKEKQVSLLLIQITEKENKMKDLTFLLE-------ESRDKVNQLE-EKTKLQSENLKQS 313
+ + L +IT + ++K L LE E++D +N E EK L+ + +
Sbjct: 618 GHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKL 677
Query: 314 IEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAH 373
Q L +E+ + KV+ R +++EE +A +C++ E +++E +AR
Sbjct: 678 KSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVA---MCEM----EKKLKEEREAREKA 730
Query: 374 SFVVTEFETTVCSLEELLRTEQQRLE-------KNEDQLKILTMELQKKSSE---LEEMT 423
V + E L+ L+ QQ+LE + ED++K LT++L+++S++ L+
Sbjct: 731 ENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNEL 790
Query: 424 KLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEI 483
K + L+ L+K + ++ L E K+ L+ +L + E ++ +L+
Sbjct: 791 KTQAFEADNLKGLEKQMKQEINTLLEAKRL------LEFELAQLTKQYRGNEGQMRELQD 844
Query: 484 QLTAITTSEQYYSKEVKDLKTELENEKLKNT----ELTSHCNKLS--LENKELTQETSDM 537
QL A Y +VK+LK E+E + +N EL + L+ L+ E E+ +
Sbjct: 845 QLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQL 904
Query: 538 TLELKNQQ--EDINNNKKQEERMLKQIEN-------LQETETQLRNELEYVR---EEL-- 583
L +Q E +KK R ++I + L+E + L ++E +R EEL
Sbjct: 905 ARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTE 964
Query: 584 KQKRDEVKCKLDKSEENCNNLRKQVENK------------NKYIEELQQENKALKKKGTA 631
K K+ E + KL+K EE +NL+ E NK E + +++ + +K A
Sbjct: 965 KMKKAEEEYKLEKEEE-ISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK-KA 1022
Query: 632 ESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADE 691
++ L E + KL+LEL ++KF ++ +QKE+ D + L+EE + +
Sbjct: 1023 NTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELND---MQAQLVEECAHRNELQMQ 1079
Query: 692 AVKLQKEIDK 701
+ +I++
Sbjct: 1080 LASKESDIEQ 1089
Score = 93.6 bits (231), Expect = 8e-19
Identities = 129/610 (21%), Positives = 259/610 (42%), Gaps = 114/610 (18%)
Query: 381 ETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVL 440
+ T+ LEE L E Q ++ E + + ++L K EL+E N E + +++K
Sbjct: 429 QKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEK-- 486
Query: 441 GEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVK 500
EK L + ++++ AE+ + + E EV L+ QL +
Sbjct: 487 -EKMLLQHRINEYQRKAEQENEKRRNV-------ENEVSTLKDQL--------------E 524
Query: 501 DLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLK 560
DLK +N +L N +L S K E +L + SD + L+ +++ + Q E + +
Sbjct: 525 DLKKVSQNSQLANEKL-SQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNR 583
Query: 561 QIEN----LQETETQLRN---ELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNK 613
+++ L+ +++Q +L+ + E ++ R + + +L+++V++
Sbjct: 584 ELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKH 643
Query: 614 YIEELQQENKALKKKGTAESKQLNVYEIKVN--------KLELELESAKQKFGEITDTYQ 665
+E+++ E K + K+ N EI +N +LE E+ K +TD +Q
Sbjct: 644 NLEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQ 703
Query: 666 KEIEDKKIS----EENLLEEVEKAKVIADEAVKLQKEID------KRCQHKIAEMVALME 715
E K ++ E+ L EE E + + V+++K+ K+ Q K+ + E
Sbjct: 704 SIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKE 763
Query: 716 KHKHQYDKI---------------------IEERDSELGLYKSKEQEQSSL---RASLEI 751
+ + + + E D+ GL K +QE ++L + LE
Sbjct: 764 RMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEF 823
Query: 752 ELSNL-------KAELLSVKKQLEIE-----------REEKEKLKREAKENTATLKEKKD 793
EL+ L + ++ ++ QLE E +E KE+++ + +EN ++E ++
Sbjct: 824 ELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQN 883
Query: 794 KK----TQTFLLET------------PEIYWKLDSKAVPSQTVSR-NFTSVDHGISKDKR 836
+K TQ L ET E Y++L ++ + + +R T DH +S+ +
Sbjct: 884 EKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEE 943
Query: 837 DYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSE 896
++ T + + + K K + E + EE K AFE +IN++ +
Sbjct: 944 ----ANSMLTKDIEILRRENEELTEKMK-KAEEEYKLEKEEEISNLKAAFEKNINTERTL 998
Query: 897 TTDLLSMVSE 906
T ++ ++E
Sbjct: 999 KTQAVNKLAE 1008
Score = 85.1 bits (209), Expect = 3e-16
Identities = 131/586 (22%), Positives = 249/586 (42%), Gaps = 105/586 (17%)
Query: 92 KDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQEL 151
++S L N E LS++ +L +EA + + + T LR+ +++ ++ +E+ + +QE
Sbjct: 531 QNSQLAN-EKLSQLQKQL-EEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQER 588
Query: 152 QFGNEKVSLKLEEGIQENKDLIKENNATR-HLCNLLKETCARSAE-----KTKKYEYERE 205
E + ++ + + +++ R H ++ + AR K K+ E+
Sbjct: 589 NRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKV 648
Query: 206 E-TRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK---KEI 261
E R+ D+ N+ EK + N +++++KLK ++++ E+K +
Sbjct: 649 EGERKEAQDMLNHSEK----------EKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARL 698
Query: 262 NDKEKQVS-LLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHL 320
DK + + + + E E K+K+ E++ ++V Q+E++ + +LKQS +K HL
Sbjct: 699 TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHL 758
Query: 321 TKELEDI-----------------KVSLQRSVSTQ-------KALEEDLQIATKTI---- 352
T E + ++ LQ + TQ K LE+ ++ T+
Sbjct: 759 TGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAK 818
Query: 353 -------CQLTEE---KETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNE 402
QLT++ E QM E A + T ++T V L+E + EKN
Sbjct: 819 RLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIE------EKNR 872
Query: 403 DQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKE--TLLYENKQF-EKIAEE 459
+ LK + ELQ + L L K E E+L + L E++ L E+K+ + +E
Sbjct: 873 ENLKKI-QELQNEKETLATQLDLAETK-AESEQLARGLLEEQYFELTQESKKAASRNRQE 930
Query: 460 LKGTEQELIGLLQAREKEVHDLEI------QLTA-ITTSEQYYS----KEVKDLKTELE- 507
+ + + L +A D+EI +LT + +E+ Y +E+ +LK E
Sbjct: 931 ITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEK 990
Query: 508 NEKLKNTELTSHCNKLS-------------------LENKELTQETSDMTLELKNQQEDI 548
N + T T NKL+ L KE +E + LEL ++E
Sbjct: 991 NINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKE--KENRKLQLELNQEREKF 1048
Query: 549 NNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKL 594
N + ++ L ++ E RNEL+ + ++++ KL
Sbjct: 1049 NQMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKL 1094
Score = 59.3 bits (142), Expect = 2e-08
Identities = 89/521 (17%), Positives = 205/521 (39%), Gaps = 71/521 (13%)
Query: 434 EELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEV------HDLEIQLTA 487
++L++ GE+ET I + G + +G + +D A
Sbjct: 369 DDLEEDKGEEETF--------PIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA 420
Query: 488 ITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQED 547
+ ++ K + L+ +L NE E+ C +++ ++ +E + + +N +
Sbjct: 421 DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST 480
Query: 548 INNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQ 607
++ +K++ + +I NE + E+ +KR V+ ++ ++ +L+K
Sbjct: 481 VSQIEKEKMLLQHRI-----------NEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKV 529
Query: 608 VENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKE 667
+N E+L Q K L++ + + +++ K E+ + + ++ +E
Sbjct: 530 SQNSQLANEKLSQLQKQLEEANDLLRTESDT-AVRLRKSHTEMSKSISQL----ESLNRE 584
Query: 668 IEDKKISEENLLEEVEKAKVIADEAVKLQK-------EIDKRCQHKIAEMVALMEKHKHQ 720
++++ EN + +K ++ ++ E+ Q +I + ++ KH
Sbjct: 585 LQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHN 644
Query: 721 YDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNL--------------KAELLSVKKQ 766
+K+ ER + E+E+++L L +L +L KA L +
Sbjct: 645 LEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQS 704
Query: 767 LE-------IEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQT 819
+E E E+K K +REA+E + +K+ ++ + KL+ +
Sbjct: 705 IEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKER 764
Query: 820 VSRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESK 879
+ ++ + ++ L +N L T +A +K K Q ++ +N +E
Sbjct: 765 MEDEVKNLTLQLEQESNKRL--LLQNELKTQAFEADNLKGLEK---QMKQEINTLLE--- 816
Query: 880 KKRKMAFEF-----DINSDSSETTDLLSMVSEEETLKTLYR 915
KR + FE + + +L + E+ TLY+
Sbjct: 817 AKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYK 857
Score = 41.6 bits (96), Expect = 0.004
Identities = 65/279 (23%), Positives = 119/279 (42%), Gaps = 42/279 (15%)
Query: 95 DLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQE--NRKIIEAQRKAIQELQ 152
+L++ + +S LYK ++K+ K E + R+ K+QE N K A + + E +
Sbjct: 841 ELQDQLEAEQYFSTLYKT--QVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETK 898
Query: 153 FGNEKVSLKLEEG-----IQENKDLIKENNAT----RHLCNLLKETCARSAEKTKKYEYE 203
+E+++ L E QE+K N H + L+E ++ TK E
Sbjct: 899 AESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEA---NSMLTKDIEIL 955
Query: 204 REETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEIND 263
R E ++ EKM A EE +++ E E LK +EK + E+ K + +
Sbjct: 956 RRENEEL-------TEKMKKAEEEYKLEKE----EEISNLKAAFEKNINTERTLKTQAVN 1004
Query: 264 K-------------EKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENL 310
K K+ + ++ EKEN+ L L + R+K NQ+ K + + ++
Sbjct: 1005 KLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLE--LNQEREKFNQMVVKHQKELNDM 1062
Query: 311 KQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIAT 349
+ + ++ EL+ S + + +A DL +T
Sbjct: 1063 QAQLVEECAHRNELQMQLASKESDIEQLRAKLLDLSDST 1101
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 125 bits (313), Expect = 3e-28
Identities = 174/799 (21%), Positives = 349/799 (43%), Gaps = 124/799 (15%)
Query: 86 HYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQR 145
H ++ L + DLE +E +++ S + + +++ + + + + E+K+ + R ++EA
Sbjct: 363 HIEQLLAERDLERAE-VAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAAD 421
Query: 146 KAIQELQFGNEKVSL--KLEEGIQENKDL---IKENNATRHLCNLLKETCARSAEKTKKY 200
+ EKV L +LEE ++ +DL ++E + T+ + A +EK++
Sbjct: 422 R---------EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEV-----ATVSEKSRIM 467
Query: 201 EYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKE 260
E E+ DL ++++ L ++M L ++ I L+++ +
Sbjct: 468 ELEK--------DLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE---ISSLQEKLEVT 516
Query: 261 INDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEE--KTKLQSENLKQS----I 314
D +++++ L +E + L + +K+++ E K+KL+ N + S +
Sbjct: 517 RTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIAL 576
Query: 315 EKQHHLT------KELEDIKVSLQRSVSTQKALEEDLQIATKTI-CQLTEEKETQMEESN 367
K T + +E++KVS + + T+ A +L+ + + E E + +
Sbjct: 577 WKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD 636
Query: 368 KARAAHSF-----------VVTEFETTVCSLEELL-RTEQQRLEKNEDQLKILTMELQKK 415
RAAH+ V+ E E ++ ++ L + E Q L + ED L L E + K
Sbjct: 637 SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL-QEAEIK 695
Query: 416 SSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQARE 475
ELE + N + ++ L E L + K + E K ++L L+A E
Sbjct: 696 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE 755
Query: 476 KEVHDLEIQLTAIT-----------------TSEQYYSKEVKDLKTELENE----KLKNT 514
K++ LEI+ A + T+ Q EV +K LE E K K
Sbjct: 756 KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA 815
Query: 515 ELTSHC---------------------NKLSLENKELTQETSDMTLELKNQQEDINNNKK 553
E + N LS + ++L + +DM + + + E K
Sbjct: 816 EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIK 875
Query: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKR---DEVKCKLDKSEENCNNLRKQVEN 610
+E++ I + + ++L + +EL+ K +E++ KL K+ EN + L+K +E+
Sbjct: 876 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIED 935
Query: 611 KNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIED 670
E+ QQE KK E K+L E K++ LE ++E++ + E+ Y++ +
Sbjct: 936 MTVKAEQSQQE---AAKKHEEEKKEL---ERKLSDLEKKMETSHNQCQELKARYERATSE 989
Query: 671 KKISEENLLEEVEKAKVIADEAVK---------LQKEIDKRCQHKIAEMVALMEKHKHQY 721
K E +L+ ++K + ++ +K LQ+ + R Q A+ E
Sbjct: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM 1049
Query: 722 DKIIEERDSELGLYKSKEQEQSSLRASLE-IELSNLK--AELLSVKKQLEIEREEKEKLK 778
+++ +E+ L + +Q + L+ L+ ++ +NLK EL K+ L +E ++ E+ +
Sbjct: 1050 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109
Query: 779 REAKENTATLKEKKDKKTQ 797
+E + TLK+ +K+Q
Sbjct: 1110 KEIE----TLKQAAAQKSQ 1124
Score = 122 bits (307), Expect = 1e-27
Identities = 181/797 (22%), Positives = 337/797 (42%), Gaps = 160/797 (20%)
Query: 95 DLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQE-NRKIIEAQRKAIQELQF 153
D++ S L + S L ++ E + L++ +E ++K I+A A ++L
Sbjct: 495 DVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK 554
Query: 154 GNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMD 213
NE + KLE +EN D+I L ET S ++ + ++ +
Sbjct: 555 ENESLKSKLEHANKENSDVIA-------LWKSKLETAIASHQQAME---------ELKVS 598
Query: 214 LNNNIEKMITAFEELRVQAENSRLEMHFKLK-----EDYEKIQH------LEQEYKKEIN 262
+ + F EL+ Q E RL+ +++ +D E+ H L + K I
Sbjct: 599 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIK 658
Query: 263 DKEKQVSLLLIQITEKENK----MKDLTFLLEESRDKVNQLE-------EKTKLQSENLK 311
+KE + + ++ + E++ M+D L+E+ KV +LE E+TK+ +N
Sbjct: 659 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKV-IDNFT 717
Query: 312 QSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARA 371
++ +L+ ++ + S K L + L+ A K I L EK ES+KA
Sbjct: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNA---ESSKA-- 772
Query: 372 AHSFVVTEF---ETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSEL--------E 420
S + E E + +L+E L Q E E +L+IL + + S E E
Sbjct: 773 --SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 830
Query: 421 EMTKLTNNKEV------ELEELKKVLGEKETLLYENKQFE----KIAEELKGTEQELIGL 470
+ KL +E +LE+L++ L + E E + E K E+L+ E++ +
Sbjct: 831 TVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKM 890
Query: 471 --------------LQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTEL 516
L+ +E++V +L+++LT + + K ++D+ + E + + +
Sbjct: 891 SGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAK- 949
Query: 517 TSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQ--------IENLQET 568
K E KEL ++ SD+ +++ K + ER + ++NLQ+T
Sbjct: 950 -----KHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKT 1004
Query: 569 ETQLRNELEYVREE---LKQKRDEVKCKLDKS---------------------------- 597
++L+ REE L Q+ +E++ + DK+
Sbjct: 1005 LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLE 1064
Query: 598 -----------------EENCNNLRKQVENK------NKYIEELQQENKALKKKGTAESK 634
E N N+ + ++K N+ +EE ++E + LK+ +S+
Sbjct: 1065 DTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQ 1124
Query: 635 QLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLE-EVEKAKVIAD--- 690
QL+ + + KL EL ++ E+T ++QK E++ + LLE + ++K I D
Sbjct: 1125 QLSALQEENVKLAEELGRSRD---EVT-SHQKLEEERSVLNNQLLEMKKRESKFIKDADE 1180
Query: 691 EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLE 750
E LQK I + E A +EK +++ + E S L+ S Q S + LE
Sbjct: 1181 EKASLQKSISITSA-LLTEKDAELEKLRNEVTVLRGENASAKSLH-SVVQTLESDKVKLE 1238
Query: 751 IELSNLKAELLSVKKQL 767
+++ NL+ +L K+QL
Sbjct: 1239 LKVKNLELQLKENKRQL 1255
Score = 109 bits (273), Expect = 1e-23
Identities = 161/701 (22%), Positives = 305/701 (43%), Gaps = 87/701 (12%)
Query: 97 ENSEGLSRVYSKLYKEAEKIKKWKVST-----EAELRQKE-----SKLQENRKIIE---A 143
E L + SKL K ++ T EAE++ KE +K E K+I+ +
Sbjct: 659 EKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 718
Query: 144 QRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYE 203
Q KA +E + + EG E K L ++ A L+ ++AE +K
Sbjct: 719 QLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE--IEKNAESSKASSIT 776
Query: 204 RE-ETRQVYM-DLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEI 261
RE + R++ + +L N+ ++ E L + + + E + E+ +Q QE ++
Sbjct: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILK-EKFAEASEEAVSVQRSMQETVNKL 835
Query: 262 NDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLT 321
+ KE+Q ++L LE+ R+ + +E K + + E +Q I+ + L
Sbjct: 836 HQKEEQFNMLSSD--------------LEKLRENLADMEAKFREKDEREEQLIKAKEKLE 881
Query: 322 KELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFE 381
++ +I + S + ++L++ + + EE + ++ ++N+ SF+ E
Sbjct: 882 NDIAEIMKMSGDNSSQLTKMNDELRLKERDV----EELQLKLTKANENA---SFLQKSIE 934
Query: 382 TTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELE-ELKKVL 440
E+ ++Q+ +K+E++ K EL++K S+LE+ + ++N+ EL+ ++
Sbjct: 935 DMTVKAEQ---SQQEAAKKHEEEKK----ELERKLSDLEKKMETSHNQCQELKARYERAT 987
Query: 441 GEKETLLYE-----NKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYY 495
E +T E K ++LKG +E GLLQ E E+ + A T+E
Sbjct: 988 SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE-ELRKQADKAKAAQTAED-- 1044
Query: 496 SKEVKDLKTELENEKLKNTELTSHCN-KLSLENKELTQETSDMTLELKNQQEDINNNKKQ 554
+ ++ + T+ + E L + E T N KL E L + EL +E + ++
Sbjct: 1045 AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK 1104
Query: 555 EERMLKQIENLQETETQLRNELEYVREE-------LKQKRDEVKCKLDKSEENC---NNL 604
E K+IE L++ Q +L ++EE L + RDEV EE N L
Sbjct: 1105 MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQL 1164
Query: 605 RKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELEL-----ESAKQK-FG 658
+ + ++K+I++ +E +L+K + S L + ++ KL E+ E+A K
Sbjct: 1165 LEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLH 1224
Query: 659 EITDTYQKEIEDKKISEENL---LEEVEKAKVIADEAVKLQKEIDKRCQHK---IAEMVA 712
+ T + + ++ +NL L+E ++ + Q + D+R Q V
Sbjct: 1225 SVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI 1284
Query: 713 LMEKHKHQYDKIIEERDSELGL---------YKSKEQEQSS 744
+ + K+Q K+ E SE L Y S +QE+ S
Sbjct: 1285 VDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQS 1325
Score = 70.5 bits (171), Expect = 7e-12
Identities = 72/347 (20%), Positives = 151/347 (43%), Gaps = 20/347 (5%)
Query: 486 TAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQ 545
TA+ + + + ++ L E + E+ + + TSH ++ E LEL+ +
Sbjct: 351 TALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKM 410
Query: 546 EDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLR 605
+ + + +R ++ N E E + +L++ EE + +++ + L
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELE 470
Query: 606 KQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIK--VNKLEL-------ELESAKQK 656
K + + + + EL++ ++ K G + + EI KLE+ E+ S K+
Sbjct: 471 KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEH 530
Query: 657 FGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVA---- 712
FG +T+QKEI+ + E L +E E K + A K ++ + K+ +A
Sbjct: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
Query: 713 LMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLK----AELLSVKKQLE 768
ME+ K + K + +E K++ ++ +R + E+ NL+ +E + K++E
Sbjct: 591 AMEELKVSFSKGLGTETAEFAELKTQIEK---MRLDYQHEIENLQNQQDSERAAHAKEME 647
Query: 769 IEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAV 815
R + K+ +E + + ++ K DK L+E + KL +
Sbjct: 648 ALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEI 694
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 124 bits (312), Expect = 3e-28
Identities = 171/755 (22%), Positives = 324/755 (42%), Gaps = 90/755 (11%)
Query: 80 VGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRK 139
+ N E LK + E S S++ + + KK K +A + + E +++ R
Sbjct: 1073 IENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIK-ELQARIEELEEEIEAERA 1131
Query: 140 IIEAQRKAIQELQFGNEKVSLKLEEG-------IQENKDLIKE-NNATRHLCNLLKETCA 191
K +L E++S +LEE I+ NK E R L + A
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
Query: 192 RSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAEN--SRLEMHFKLKEDYEK 249
+A KK+ E + +L +K+ E++++ ++ S +E K K + EK
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEK 1251
Query: 250 IQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSEN 309
+ ++ EI KE++ L+ +T + +++ ES + QL+EK L S
Sbjct: 1252 MCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQT------ESGEYSRQLDEKDTLVS-- 1303
Query: 310 LKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKA 369
Q + T+++E++K L+ + + AL LQ +++ C L E Q EE +A
Sbjct: 1304 --QLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQ-SSRHDCDLLRE---QYEEEQEA 1357
Query: 370 RAAHSFVVTEFETTVCSLEELLRTEQ-QRLEKNEDQLKILTMELQKKSSELEEMTKLTNN 428
+A +++ + V T+ QR E+ E+ K L LQ + EE + N
Sbjct: 1358 KAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ----DAEEHVEAVNA 1413
Query: 429 KEVELEELKKVL-GEKETLLYE--------------NKQFEKIAEELKGTEQELIGLLQA 473
K LE+ K+ L E E L+ + + F+KI E K +E L+A
Sbjct: 1414 KCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1473
Query: 474 REKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQE 533
+KE L +L I + Y + + L+T L ENK L QE
Sbjct: 1474 SQKESRSLSTELFKIKNA---YEESLDQLET------------------LKRENKNLQQE 1512
Query: 534 TSDMTLELK---NQQEDINNNKKQEERMLKQIE-NLQETETQLRNE---LEYVREELKQK 586
SD+T ++ + ++ KKQ E+ +++ L+E E L +E + ++ EL Q
Sbjct: 1513 ISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQV 1572
Query: 587 RDEVKCKLDKSEENCNNLRKQ----VENKNKYIE-ELQQENKALKKKGTAESKQLNVYEI 641
+ EV K+ + +E + +++ VE+ ++ E++ N A++ K E LN EI
Sbjct: 1573 KSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEG-DLNEMEI 1631
Query: 642 KVNKLELELESAKQKFGE---ITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKE 698
++N A + + I Q ++D S+E+L E++ ++ A LQ E
Sbjct: 1632 QLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQL---AMVERRANLLQAE 1688
Query: 699 IDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKA 758
I+ ++ + E+ + ++ + + + L ++ + + LE ++S ++
Sbjct: 1689 IE-----ELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQG 1743
Query: 759 ELLSVKKQLEIEREEKEKLKREAKENTATLKEKKD 793
E+ + ++ E+ +K +A LK+++D
Sbjct: 1744 EMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQD 1778
Score = 120 bits (300), Expect = 8e-27
Identities = 186/868 (21%), Positives = 390/868 (44%), Gaps = 121/868 (13%)
Query: 111 KEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENK 170
KE + + + AEL K+ KL++ + +K I +L+ KV + E+ ENK
Sbjct: 924 KEVTERAEDEEEINAELTAKKRKLEDECSEL---KKDIDDLELTLAKV--EKEKHATENK 978
Query: 171 DLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRV 230
N T + L ET A+ ++ K + ++T + + + A +L
Sbjct: 979 ----VKNLTEEMAGL-DETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQ 1033
Query: 231 QAEN--SRLEMHFKLKEDYEK------------------IQHLEQEYKKEINDKEKQVSL 270
Q ++ LE K++ D E+ I++ +Q+ +++ KE ++S
Sbjct: 1034 QVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSG 1093
Query: 271 LLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVS 330
L +I +++ L ++E + ++ +LEE+ + + + ++ +++ L++ELE+I
Sbjct: 1094 LQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER 1153
Query: 331 LQRS-------VSTQKALEEDLQIATKTICQLTEEKETQMEESNKA--RAAHSFVVTEFE 381
L+ + + K E + Q + + E+ T E+ A R H+ V E
Sbjct: 1154 LEEAGGATSAQIEMNKKREAEFQKMRRDL-----EEATLQHEATAATLRKKHADSVAELG 1208
Query: 382 TTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLG 441
+ +L+ + +Q+LEK + ++K ME+ +S +E ++K N E L+ L
Sbjct: 1209 EQIDNLQRV----KQKLEKEKSEMK---MEIDDLASNMETVSKAKGNLEKMCRALEDQLS 1261
Query: 442 EKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKD 501
E +T + ++ +++ +L L +++ + + ++ ++ +Q +++++++
Sbjct: 1262 EIKT---KEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318
Query: 502 LKTELENEKLKNTELTSHCNKLSLEN----KELTQETSDMTLELKNQQEDINN-----NK 552
LK +LE E++K +H + S + +E +E + EL+ N+
Sbjct: 1319 LKRQLE-EEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRT 1377
Query: 553 KQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKN 612
K E +++ E L+E + +L L+ E + + V K E+ L+ +VE+
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQDAEEHV----EAVNAKCASLEKTKQRLQNEVEDLM 1433
Query: 613 KYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKK 672
+E AL KK K L ++ K + ELE+++++ + + E+ K
Sbjct: 1434 IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE----SRSLSTELFKIK 1489
Query: 673 ISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKI---IEERD 729
+ E L+++E K E LQ+EI + E +A K H+ +KI +E+
Sbjct: 1490 NAYEESLDQLETLK---RENKNLQQEIS-----DLTEQIAEGGKRIHELEKIKKQVEQEK 1541
Query: 730 SELGLYKSKEQEQSSLR------ASLEIELSNLKAELLSVKKQLEIEREEKEKLKR---- 779
SE L + E+ ++SL +++EL+ +K+E V +++ + EE +++KR
Sbjct: 1542 SE--LQAALEEAEASLEHEEGKILRIQLELNQVKSE---VDRKIAEKDEEIDQMKRNHIR 1596
Query: 780 --EAKENT--ATLKEKKD----KKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGI 831
E+ ++T A ++ + D KK L EI +L+ + RN+ + I
Sbjct: 1597 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEI--QLNHANRMAAEALRNYRNT-QAI 1653
Query: 832 SKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQR--ENLNIPIEESKKKRKMAFEFD 889
KD + +L + ++ K + L Q E L +E++++ RK+A +
Sbjct: 1654 LKDTQLHLDDALRSQEDL---KEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL 1710
Query: 890 INSDSSETTDLL-----SMVSEEETLKT 912
+ D+SE LL S+++ ++ L+T
Sbjct: 1711 L--DASERVQLLHTQNTSLINTKKKLET 1736
Score = 107 bits (267), Expect = 5e-23
Identities = 135/658 (20%), Positives = 276/658 (41%), Gaps = 66/658 (10%)
Query: 79 QVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENR 138
Q DC + + E L R SK E + +W+ E + Q+ +L+E +
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRAMSKANSE---VAQWRTKYETDAIQRTEELEEAK 1394
Query: 139 KIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTK 198
K KL + +Q+ ++ ++ NA CA S EKTK
Sbjct: 1395 K---------------------KLAQRLQDAEEHVEAVNAK----------CA-SLEKTK 1422
Query: 199 KYEYEREETRQVYMDLNNN----IEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLE 254
+ E + ++ N ++K F+++ + + E H +L+ ++ + L
Sbjct: 1423 QRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLS 1482
Query: 255 QEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSI 314
E K N E+ + L E +N ++++ L E+ + ++ E K++ KQ
Sbjct: 1483 TELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK----KQVE 1538
Query: 315 EKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHS 374
+++ L LE+ + SL+ ++ +L + + EK+ EE ++ + H
Sbjct: 1539 QEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD---EEIDQMKRNHI 1595
Query: 375 FVVTEFETTVCSLEELLRTEQQRLEKN-EDQLKILTMELQKKSSELEEMTKLTNNKEVEL 433
+V ++T+ E R + RL+K E L + ++L + E + N + L
Sbjct: 1596 RIVESMQSTL-DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAIL 1654
Query: 434 EELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQ 493
++ + L + + E + E+L E+ LLQA E+ +L L S +
Sbjct: 1655 KDTQLHLDDAL------RSQEDLKEQLAMVERRA-NLLQA---EIEELRATLEQTERSRK 1704
Query: 494 YYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKK 553
+E+ D ++ +NT L + KL + ++ E D+ E +N +E
Sbjct: 1705 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAIT 1764
Query: 554 QEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENC-NNLRKQVENKN 612
M ++++ Q+T L E +++ L+Q +++ +LD++E+ +KQ++
Sbjct: 1765 DAAMMAEELKKEQDTSAHL----ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1820
Query: 613 KYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKK 672
+ EL+ E ++ +K+ K L +E KV +L + E ++ + D K K
Sbjct: 1821 ARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1880
Query: 673 ISEENLLEEVEKAKVIADEAVKLQKEI---DKRCQHKIAEMVALMEKHKHQYDKIIEE 727
+ E E++ V + ++Q E+ ++R +++ L K + + KII E
Sbjct: 1881 SYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISE 1938
Score = 105 bits (262), Expect = 2e-22
Identities = 135/600 (22%), Positives = 266/600 (44%), Gaps = 71/600 (11%)
Query: 302 KTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKET 361
+T+ + N+K+ EK TKE L ++ + +K LEE + T+ Q + +
Sbjct: 848 ETEKEMANMKEEFEK----TKE------ELAKTEAKRKELEEKM----VTLMQEKNDLQL 893
Query: 362 QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEE 421
Q++ + A + T LE ++ +R E E+ LT + +K E E
Sbjct: 894 QVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 422 MTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQ-------ELIGLLQAR 474
+ K ++ E+ L ++ EKE ENK + + EE+ G ++ E L +A
Sbjct: 954 LKKDIDDLELTLAKV-----EKEKHATENK-VKNLTEEMAGLDETIAKLTKEKKALQEAH 1007
Query: 475 EKEVHDL---EIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELT 531
++ + DL E ++ +T ++ ++V DL+ LE EK +L KL + K L
Sbjct: 1008 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLK-LA 1066
Query: 532 QETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVK 591
QE+ T++++N ++ ++ K++E + +++ E E L +L+ +EL+ + +E++
Sbjct: 1067 QES---TMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELE 1123
Query: 592 CKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNV---YEIKVNKLEL 648
+++ + KQ + ++ +EE+ + L++ G A S Q+ + E + K+
Sbjct: 1124 EEIEAERASRAKAEKQRSDLSRELEEISER---LEEAGGATSAQIEMNKKREAEFQKMRR 1180
Query: 649 ELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAK-VIADEAVKLQKEIDKRCQHKI 707
+LE A + T +K+ D ++ +++ K + E +++ EID +
Sbjct: 1181 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID-----DL 1235
Query: 708 AEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQL 767
A + + K K +K+ + +L K+KE+EQ L L + + L+ E +QL
Sbjct: 1236 ASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQL 1295
Query: 768 EIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSV 827
+EK+ TL + + Q F + E+ +L+ + ++ S
Sbjct: 1296 ----DEKD-----------TLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSS 1340
Query: 828 DHGISKDKRDY-LWTSAKNTLSTPLPKAYTVKTPTKPK-----LQQRENLNIPIEESKKK 881
H + Y AK L + KA + + K +Q+ E L EE+KKK
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEEL----EEAKKK 1396
Score = 103 bits (256), Expect = 1e-21
Identities = 140/717 (19%), Positives = 317/717 (44%), Gaps = 97/717 (13%)
Query: 237 LEMHFKLK------EDYEKIQHLEQEYKKEIND------KEKQVSLLLIQITEKENKMKD 284
++++FK+K E +++ ++++E++K + K K++ ++ + +++N D
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKN---D 890
Query: 285 LTFLLEESRDKVNQLEE------KTKLQSE----NLKQSIEKQHHLTKELEDIKVSLQRS 334
L ++ D + EE KTK+Q E + + E + + EL K L+
Sbjct: 891 LQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDE 950
Query: 335 VSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTE 394
S K +DL++ + + E +++ + A + + +L+E +
Sbjct: 951 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQT 1010
Query: 395 QQRLEKNEDQLKILT---MELQKKSSELEEMTKLTNNKEVELEELKK------VLGEKET 445
L+ ED++ LT ++L+++ +LE + ++LE K+ L ++ T
Sbjct: 1011 LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQEST 1070
Query: 446 LLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTE 505
+ EN + +++ E+LK E E+ G LQ++ ++ L +QL Q +++L+ E
Sbjct: 1071 MDIENDK-QQLDEKLKKKEFEMSG-LQSKIEDEQALGMQLQKKIKELQ---ARIEELEEE 1125
Query: 506 LENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENL 565
+E E+ + + LS E +E+++ + Q I NKK+E K +L
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQ---IEMNKKREAEFQKMRRDL 1182
Query: 566 QE-------TETQLR--------------NELEYVREELKQKRDEVKCKLDKSEENCNNL 604
+E T LR + L+ V+++L++++ E+K ++D N +
Sbjct: 1183 EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETV 1242
Query: 605 RKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTY 664
K N K L+ + +K K E +Q + ++ + L+ ES + Y
Sbjct: 1243 SKAKGNLEKMCRALEDQLSEIKTK--EEEQQRLINDLTAQRARLQTESGE---------Y 1291
Query: 665 QKEIEDKKISEENLLEEVEKAK-VIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDK 723
+++++K + L+ ++ + K + +L++++++ + K A + ++ +H D
Sbjct: 1292 SRQLDEK----DTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSA-LAHALQSSRHDCDL 1346
Query: 724 IIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKR--EA 781
+ E+ + E E +++ +A+ E+ K E ++++ E+E +K+ +R +A
Sbjct: 1347 LREQYEEE--QEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDA 1404
Query: 782 KENTATLKEK---KDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDY 838
+E+ + K +K Q E ++ ++ + + + D +++ K+
Sbjct: 1405 EEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKC 1464
Query: 839 LWTSAK--------NTLSTPLPKAYTVKTPTKPKLQ--QRENLNIPIEESKKKRKMA 885
T A+ +LST L K + +L+ +REN N+ E S ++A
Sbjct: 1465 EETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1521
Score = 85.5 bits (210), Expect = 2e-16
Identities = 111/527 (21%), Positives = 229/527 (43%), Gaps = 50/527 (9%)
Query: 415 KSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAR 474
KS+E E+ ++ N KE E E+ K+ L + E + K+ E+ L + +L +QA
Sbjct: 845 KSAETEK--EMANMKE-EFEKTKEELAKTEA---KRKELEEKMVTLMQEKNDLQLQVQAE 898
Query: 475 EKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQET 534
+ D E + + ++ ++K++ E+E+ N ELT+ KL E EL ++
Sbjct: 899 ADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958
Query: 535 SDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKL 594
D+ L L +++ + + + + + +++ L ET +L E + ++E +Q D+++ +
Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE 1018
Query: 595 D----------KSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVN 644
D K E+ ++L +E + K +L++ + K +G + Q + +I+ +
Sbjct: 1019 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKR--KLEGDLKLAQESTMDIEND 1076
Query: 645 KLELELESAKQKF------GEITD------TYQKEIEDKKISEENLLEEVEKAKVIADEA 692
K +L+ + K++F +I D QK+I++ + E L EE+E + +A
Sbjct: 1077 KQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKA 1136
Query: 693 VKLQKEIDKRCQH----------KIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQ 742
K + ++ + + + + + +K + ++ K+ + + +++
Sbjct: 1137 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1196
Query: 743 SSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLE 802
A EL L VK++LE E+ E + + N T+ + K +
Sbjct: 1197 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKG-NLEKMCRA 1255
Query: 803 TPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDY-LWTSAKNTLSTPLPKAYTVKTPT 861
+ ++ +K Q + + T+ + + +Y K+TL + L + T
Sbjct: 1256 LEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFT-- 1313
Query: 862 KPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSMVSEEE 908
QQ E L +EE + K K A + S S DLL EEE
Sbjct: 1314 ----QQIEELKRQLEE-EIKAKSALAHALQS-SRHDCDLLREQYEEE 1354
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 124 bits (311), Expect = 4e-28
Identities = 182/874 (20%), Positives = 375/874 (42%), Gaps = 131/874 (14%)
Query: 111 KEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENK 170
KE + ++ +KE + +N+ I + Q++Q ++V ++E I
Sbjct: 366 KERSNVVITRMKDRIGTLEKEHNVFQNK--IHVSYQETQQMQMKFQQVREQMEAEIAH-- 421
Query: 171 DLIKENNATRHLCNLLKETCARSAEKTK-KYEYEREETRQVYMDLNNNIEKMITAFEELR 229
+K+ N +L++ + + + + K E + RQ Y L N + + ++
Sbjct: 422 --LKQENG------ILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEE 473
Query: 230 VQ---AENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLT 286
VQ AE + ++ +L+E + + ++ +K + E L + KEN+++ L
Sbjct: 474 VQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLH 533
Query: 287 FLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDI-------KVSLQRSVSTQK 339
L ++ QLE++ E+ ++ + K+ L +++DI K +Q+ +Q
Sbjct: 534 SKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQ-FHSQI 592
Query: 340 ALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEE---LLRTEQQ 396
A + + + + ++ EK+ Q++++ + A+ +T E + ++ LL+ E Q
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 397 RLEK---------------------NEDQLKILTMELQKKSSELEEMTKLTNNK----EV 431
+L+ +D++++L +LQ + S E K+ N++ +
Sbjct: 653 KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKS 712
Query: 432 ELEELKKVLGE---KETLLYENKQFEKIAEELKGTEQEL-IGLLQAREKEVHDLEIQLTA 487
E+++L+ ++ E K+ + K ++ E+LK E+ L GL+Q KE +L A
Sbjct: 713 EVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE-----ELNA 767
Query: 488 ITTSEQYYSKEVKDLKTELENE-------------------KLKNTELTSHCNKLSLENK 528
I T +KEV+DLK + ++ K+K+ E L + NK
Sbjct: 768 IRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK 827
Query: 529 ELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRD 588
E T D+ E+K +E+I N + ++ + L +QE + L+ + +++ +
Sbjct: 828 EKT--VQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGK--------EEQMN 877
Query: 589 EVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLEL 648
+K L++ E K + N K++++LQ+EN++LK E Q N+ E
Sbjct: 878 TMKAVLEEKE-------KDLANTGKWLQDLQEENESLKAH-VQEVAQHNLKEASSASQFE 929
Query: 649 ELESA-KQKFGEI--TDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQH 705
ELE K+K E+ + KE E S+ LL++V+ DE + +I++ Q
Sbjct: 930 ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ------DENKLFKSQIEQLKQQ 983
Query: 706 KIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKK 765
+ + H+ + K+I ER+ E+ + L EL +LK + +K
Sbjct: 984 NY-QQASSFPPHE-ELLKVISEREKEI--------------SGLWNELDSLKDAVEHQRK 1027
Query: 766 QLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFT 825
+ +++ E ++ EAKE L K + E + K + + + S
Sbjct: 1028 KNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVK 1087
Query: 826 SVDHGISK-DKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQREN-LNIPIEESKKKRK 883
++H + + D+ L + L + + + ++Q EN + ++ES K K
Sbjct: 1088 VLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIK 1147
Query: 884 M------AFEFDINSDSSETTDLLSMVSEEETLK 911
+ E ++ SE D+ ++ E E L+
Sbjct: 1148 QMQSSFTSSEQELERLRSENKDIENLRREREHLE 1181
Score = 112 bits (281), Expect = 1e-24
Identities = 172/830 (20%), Positives = 350/830 (42%), Gaps = 128/830 (15%)
Query: 70 KVNFLPVLEQVGNSDCHYQE--GLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAEL 127
++ F V EQ+ H ++ G+ + N+ +++ SK E K+++ EL
Sbjct: 405 QMKFQQVREQMEAEIAHLKQENGILRDAVSNTT--NQLESKQSAELNKLRQDYARLVNEL 462
Query: 128 RQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLK 187
+K KLQ+ + +A +L+ ++ + EE + E+ A + +L
Sbjct: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQ--DLQS 520
Query: 188 ETCARSAEKTKKYE------YEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHF 241
+ A+ E + +++ Q M L + +K + E L++Q ++ LE +
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDI-LEQNE 579
Query: 242 KLKEDYEKIQH----------LEQEYKKEINDKEKQVSLL-------LIQITEKENKMKD 284
LK ++ L +E K I +K+KQ+ ++T KE ++KD
Sbjct: 580 ALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKD 639
Query: 285 L---TFLLEESRDKVNQLEEKTKLQS---ENLKQSI------------EKQHHLTKELED 326
+ FLL+ K+ L + + E ++QS+ + QH ++ ++E+
Sbjct: 640 IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEE 699
Query: 327 IKVSLQRSVSTQKALEEDLQIATKTICQ-----LTEEKETQMEESN-KARAAHSFVVTEF 380
K+ ++ KAL+ ++Q + + + E+ E ++E + K + + T
Sbjct: 700 FKILNDQN----KALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL 755
Query: 381 ETTVCSLEEL--LRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELE---- 434
EEL +RTE L K LK + +S +EE+ K+ + K+ +++
Sbjct: 756 IQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE 815
Query: 435 ----ELKKVLGEKETLLYENKQFEKIAEELKGTE-------------QELIGLLQAREKE 477
EL KV +++T+ ++ + + EE+ + QEL LL+ +E++
Sbjct: 816 LLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQ 875
Query: 478 VHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDM 537
++ ++ L K ++DL+ E E+ K E+ H +L+ + ++
Sbjct: 876 MNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQH----NLKEASSASQFEEL 931
Query: 538 TLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVR-------EELKQKRDEV 590
+ LK ++ ++ K+ E MLK+ E+ ++TQL +++ E+LKQ+ +
Sbjct: 932 EIVLKEKENEL----KRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQ 987
Query: 591 KCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELEL 650
EE L K + + K I L E +LK + K+ N + +V +ELE
Sbjct: 988 ASSFPPHEE----LLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEA 1043
Query: 651 ESAKQK------------FGEITDTYQKEI----------EDKKISEENLLEEVEKAKVI 688
+ +K +GE ++K+ E+ K+ E L E E ++
Sbjct: 1044 KEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLL 1103
Query: 689 ADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSEL----GLYKSKEQEQSS 744
E K K + + + ++ +E+ ++++ ++E + + S EQE
Sbjct: 1104 QLECEKY-KSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELER 1162
Query: 745 LRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDK 794
LR+ + ++ NL+ E ++ +LE E+ E +E A L E K
Sbjct: 1163 LRSENK-DIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTK 1211
Score = 97.4 bits (241), Expect = 6e-20
Identities = 154/742 (20%), Positives = 316/742 (42%), Gaps = 119/742 (16%)
Query: 113 AEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDL 172
AE++ K + +++Q E L R + ++ + ++++Q N LK E +Q+ + L
Sbjct: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQ--NMNFLLKAE--VQKLQAL 657
Query: 173 IKENNATRHLCNLLKETCARSAEKTKKYEYERE-------ETRQVYMDLNNNIEKMITAF 225
E A H ++++ +K + E + + E ++ D N ++ +
Sbjct: 658 ANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKL 717
Query: 226 EELRVQAENSRL--EMHFKLKEDYEKIQHLEQEYKK---EINDKEKQVSLLLIQ------ 274
+ L + N + +M ++E EK++ +E+ + ++ KE++++ + +
Sbjct: 718 QTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTK 777
Query: 275 ----ITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVS 330
+ K+N L+EE + +++ + K K E L+ + K + K ++D+K
Sbjct: 778 EVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQE 837
Query: 331 LQR------SVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTV 384
++ +V +KA + + + + L + KE QM N +A + T
Sbjct: 838 IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM---NTMKAVLEEKEKDLANTG 894
Query: 385 CSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKE 444
L++L + E + L+ + ++ ++ +S+ EE+ + KE EL+ L+ +L E+E
Sbjct: 895 KWLQDL-QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERE 953
Query: 445 TLLY-----------ENKQFEKIAEELKGTE----------QELIGLLQAREKEVHDLEI 483
+ L ENK F+ E+LK +EL+ ++ REKE+ L
Sbjct: 954 SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLW- 1012
Query: 484 QLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKN 543
E+ LK +E+++ KN E + LE KE+ ++ N
Sbjct: 1013 -------------NELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSN 1059
Query: 544 QQ--EDINNNKKQEERMLKQIENLQETETQLRNELEYVREE---LKQKRDEVKCKLDKSE 598
E ++ +K+ + + +E + L ++L+ E L+ + ++ K L ++E
Sbjct: 1060 LSYGEWLHGFEKKAKECMAGTSGSEEVKV-LEHKLKEADEMHTLLQLECEKYKSVLAETE 1118
Query: 599 ENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFG 658
L++ VE Q+ENK K K K + + E ELE + +
Sbjct: 1119 GILQKLQRSVE---------QEENK-WKVKVDESHKTIKQMQSSFTSSEQELERLRSE-- 1166
Query: 659 EITDTYQKEIEDKKISEENLLEEVEKAKV---------------IADEAVKLQKEIDKRC 703
K+IE+ + E+L E+EKA++ + + KL+ E ++R
Sbjct: 1167 ------NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQ 1220
Query: 704 Q-----HKIAEMVALMEKH--KHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNL 756
+ HK + + L++ K D + E +S E+E S+ SL ++ L
Sbjct: 1221 KVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV--SLNQTVTQL 1278
Query: 757 KAELLSVKKQLEIEREEKEKLK 778
+ L +V +QL E+E + L+
Sbjct: 1279 QQLLQAVNQQLTKEKEHYQVLE 1300
Score = 89.0 bits (219), Expect = 2e-17
Identities = 162/724 (22%), Positives = 297/724 (41%), Gaps = 135/724 (18%)
Query: 185 LLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMI--TAFEELRVQAENS----RLE 238
L +ET S KK ++++T V++D E +I T + L A++S + E
Sbjct: 196 LHQETKQESGSGKKKASSKKQKTENVFVD-----EPLIHATTYIPLMDNADSSPVVDKRE 250
Query: 239 MHFKLKEDY-EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVN 297
+ LK D E IQ + K DKE ++ + +K + F +E+ V+
Sbjct: 251 VIDLLKPDQVEGIQKSGTKKLKTETDKENAE----VKFKDFLLSLKTMMFSEDEALCVVD 306
Query: 298 QLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTIC-QLT 356
L+EK+ + + LK+S + EL + LQ A++ED ATK C QLT
Sbjct: 307 LLKEKSGVIQDALKKSSKG------ELTTLIHQLQEKDKLLAAVKEDAA-ATKDRCKQLT 359
Query: 357 EEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKS 416
+E T+ E SN V+T + + +LE+ Q ++ + + + + M+ Q+
Sbjct: 360 QEMMTEKERSN-------VVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVR 412
Query: 417 SELE------------------------------EMTKLTNNKEVELEELKKVLGEKETL 446
++E E+ KL + + EL + G+ +
Sbjct: 413 EQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQE 472
Query: 447 LYENKQFEKIAEELK-------------------------GTEQELIGLLQAREKEVHDL 481
+ K E+ A +LK +Q+L A+E EV L
Sbjct: 473 EVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL 532
Query: 482 EIQLTAITTSEQYYSKEVKDL---------KTEL----------ENEKLKNTELTSHC-- 520
+LT S+Q + + L K E +NE LK H
Sbjct: 533 HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQI 592
Query: 521 ---NKLSLENKELTQETSDMTLELKNQQEDINNNKKQ---EERMLKQIEN---LQETETQ 571
S+ +EL + ++ ++K ++ + + + + +E LK I+N L + E Q
Sbjct: 593 AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
Query: 572 ----LRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK 627
L NE EL++ + V K DK L+ ++ NK + + L +NKALK
Sbjct: 653 KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKS 712
Query: 628 KGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKV 687
+ + Q V E + ++E Q+ E T ++ +E I + + E+
Sbjct: 713 E--VQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLI---QVATKEEELNA 767
Query: 688 IADEAVKLQKEID--KRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSL 745
I E L KE+ K Q+ +L+E+ K K+I E+D ++ + + +
Sbjct: 768 IRTENSSLTKEVQDLKAKQNDQVSFASLVEELK----KVIHEKDGKIKSVEELLEAELLK 823
Query: 746 RASLEIELSNLKAELLSVKKQL---EIEREEKEKLKREAKENTATLKEKKDK-KTQTFLL 801
A+ E + +LK E+ ++K+++ ++E+ ++ + + +E LK K+++ T +L
Sbjct: 824 VANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVL 883
Query: 802 ETPE 805
E E
Sbjct: 884 EEKE 887
Score = 79.7 bits (195), Expect = 1e-14
Identities = 140/670 (20%), Positives = 283/670 (42%), Gaps = 106/670 (15%)
Query: 68 LQKVNFL-----PVLEQVGNSDC---HYQEGLKDSDLENSEGLSRVYSKLYKE-AEKIKK 118
+Q +NFL L+ + N H E ++ S + + + +L E + K+++
Sbjct: 640 IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEE 699
Query: 119 WKVSTEAE--LRQKESKLQE------NRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENK 170
+K+ + L+ + KLQ N+ ++E K IQE + V LE G+ +
Sbjct: 700 FKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVA 759
Query: 171 DLIKENNATR-HLCNLLKETCARSAEKTKKYEYER--EETRQVYMDLNNNIEKMITAFEE 227
+E NA R +L KE A++ + + EE ++V + + I+ + E
Sbjct: 760 TKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEA 819
Query: 228 LRVQAENSR-----LEMHFK-LKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENK 281
++ N L+ K LKE+ +Q LE+ + I K +++ LL E+ N
Sbjct: 820 ELLKVANKEKTVQDLKQEIKALKEEIGNVQ-LEKAQQLSITSKVQELQNLLKGKEEQMNT 878
Query: 282 MKDLTFLLEESRDKVNQLEEKTKLQSEN--LKQSIEK--QHHLTK-----ELEDIKVSLQ 332
MK + L E+ +D N + LQ EN LK +++ QH+L + + E++++ L+
Sbjct: 879 MKAV--LEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLK 936
Query: 333 RSVSTQKALE-------EDLQIATKTICQLTEEKET------QMEESNKARAAHSF---- 375
+ K LE DL T+ + + +E + Q+++ N +A+ SF
Sbjct: 937 EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS-SFPPHE 995
Query: 376 ----VVTEFETTVCSLEELLRT-----EQQRLEKNEDQLKILTMELQKKS---------- 416
V++E E + L L + E QR + NE Q ++ +EL+ K
Sbjct: 996 ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVS 1055
Query: 417 ----------------SELEEMTKLTNNKEVELEELK-KVLGEKETLLY-ENKQFEKIAE 458
E M + ++EV++ E K K E TLL E ++++ +
Sbjct: 1056 VPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLA 1115
Query: 459 ELKGTEQELIGLLQAREK-------EVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKL 511
E +G Q+L ++ E E H Q+ + TS + + ++ ++EN +
Sbjct: 1116 ETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR 1175
Query: 512 KNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQ 571
+ L K +E E ++ +L + + + +++ + Q++
Sbjct: 1176 EREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLEL 1235
Query: 572 LRNEL-EYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGT 630
+++++ + + + +V + + SE+ ++ + N+ + +LQQ +A+ ++ T
Sbjct: 1236 IQSKIVKAAGDTTVIENSDVSPETESSEKETMSV-----SLNQTVTQLQQLLQAVNQQLT 1290
Query: 631 AESKQLNVYE 640
E + V E
Sbjct: 1291 KEKEHYQVLE 1300
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,825,786
Number of Sequences: 37866
Number of extensions: 1640499
Number of successful extensions: 30578
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 673
Number of HSP's successfully gapped in prelim test: 1405
Number of HSP's that attempted gapping in prelim test: 7765
Number of HSP's gapped (non-prelim): 8812
length of query: 976
length of database: 18,247,518
effective HSP length: 112
effective length of query: 864
effective length of database: 14,006,526
effective search space: 12101638464
effective search space used: 12101638464
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.