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Search of human proteins with 34577083
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
(224 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 451 e-127
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 451 e-127
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 99 4e-21
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 98 5e-21
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 98 5e-21
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 98 5e-21
gi|45827729 scribble isoform b [Homo sapiens] 98 7e-21
gi|45827731 scribble isoform a [Homo sapiens] 98 7e-21
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 95 4e-20
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 95 4e-20
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 95 6e-20
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 94 7e-20
gi|62241040 leucine rich repeat containing 8 family, member A [H... 94 9e-20
gi|187829877 leucine rich repeat containing 8 family, member A [... 94 9e-20
gi|187829871 leucine rich repeat containing 8 family, member A [... 94 9e-20
gi|197333706 leucine rich repeat containing 8 family, member D [... 93 2e-19
gi|34222199 leucine rich repeat containing 8 family, member D [H... 93 2e-19
gi|197333692 leucine rich repeat containing 8 family, member B [... 93 2e-19
gi|21245134 leucine rich repeat containing 8 family, member B [H... 93 2e-19
gi|14249428 leucine-rich repeats and calponin homology (CH) doma... 92 4e-19
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 92 5e-19
gi|40217803 leucine rich repeat containing 8 family, member E [H... 92 5e-19
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 91 1e-18
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 89 2e-18
gi|238908508 leucine-rich repeat and death domain-containing pro... 88 7e-18
gi|61742786 leucine rich repeat and death domain containing prot... 84 7e-17
gi|61742784 leucine rich repeat and death domain containing prot... 84 7e-17
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 83 2e-16
gi|4503743 flightless I homolog [Homo sapiens] 82 3e-16
gi|223005922 leucine rich repeat containing 10-like [Homo sapiens] 82 5e-16
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 451 bits (1159), Expect = e-127
Identities = 224/224 (100%), Positives = 224/224 (100%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV
Sbjct: 54 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 113
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP
Sbjct: 114 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 173
Query: 121 KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV 180
KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV
Sbjct: 174 KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV 233
Query: 181 FEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR 224
FEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR
Sbjct: 234 FEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR 277
Score = 54.7 bits (130), Expect = 6e-08
Identities = 29/89 (32%), Positives = 49/89 (55%)
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
+D++ +S F L+ + L LS N ++PP+I +L L++L+ +N + LP
Sbjct: 20 VDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELP 79
Query: 121 KEIGELTQLKELHIQGNRLTVLPPELGNL 149
+I L +LK L++ NRL LP G+L
Sbjct: 80 TQISSLQKLKHLNLGMNRLNTLPRGFGSL 108
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 451 bits (1159), Expect = e-127
Identities = 224/224 (100%), Positives = 224/224 (100%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV
Sbjct: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP
Sbjct: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
Query: 121 KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV 180
KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV
Sbjct: 121 KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV 180
Query: 181 FEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR 224
FEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR
Sbjct: 181 FEYIRSETYKYLYGRHMQANPEPPKKNNDKSKKISRKPLAAKNR 224
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 98.6 bits (244), Expect = 4e-21
Identities = 60/148 (40%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P ++ +L+ LE L+ NN+I LP I +L LK L L N+L+ LP+ G+L L L
Sbjct: 166 LPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCL 225
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
D++ N L LP LT+L L +S N E +P IGKL KL IL + N L LP+
Sbjct: 226 DVSENRLER--LPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPE 283
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
+GE L EL + N+L LP +G L
Sbjct: 284 AVGECESLTELVLTENQLLTLPKSIGKL 311
Score = 96.3 bits (238), Expect = 2e-20
Identities = 61/160 (38%), Positives = 83/160 (51%), Gaps = 8/160 (5%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I LKNL L+ N++E LP +IS L L L + N L T+P G G L L +L
Sbjct: 212 LPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSIL 271
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+ N L++ LP +L L L++N LP IGKL KL L+ N L+SLPK
Sbjct: 272 KVDQNRLTQ--LPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPK 329
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGN------LDLTGQK 155
EIG L ++ NRLT +P E+ LD+ G +
Sbjct: 330 EIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNR 369
Score = 93.2 bits (230), Expect = 2e-19
Identities = 56/148 (37%), Positives = 82/148 (55%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+PP IA L L+ N+I E+P IS + L+ + N L LP F L L L
Sbjct: 74 LPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCL 133
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+ N++S SLP N L L +L L +N LP + +L +L+ L L +N++ +LP+
Sbjct: 134 SV--NDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPE 191
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
IG L LK+L + GN+L+ LP E+GNL
Sbjct: 192 SIGALLHLKDLWLDGNQLSELPQEIGNL 219
Score = 86.7 bits (213), Expect = 2e-17
Identities = 57/149 (38%), Positives = 79/149 (53%), Gaps = 2/149 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P NI L NL L N + LP ++ L++L+ L+LG N + LP G+L L+ L
Sbjct: 143 LPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDL 202
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N LSE LP L L L +S+N E LP +I LT L L + N L ++P
Sbjct: 203 WLDGNQLSE--LPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPD 260
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLD 150
IG+L +L L + NRLT LP +G +
Sbjct: 261 GIGKLKKLSILKVDQNRLTQLPEAVGECE 289
Score = 58.9 bits (141), Expect = 3e-09
Identities = 40/96 (41%), Positives = 51/96 (53%), Gaps = 5/96 (5%)
Query: 57 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 116
+LE L L N L E LP FF L LR L LSDN+ + LPP+I +L L + N++
Sbjct: 37 SLEELLLDANQLRE--LPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNEI 94
Query: 117 ISLPKEIGELTQLKELHIQGNRLTVLP---PELGNL 149
+P+ I L+ GN LT LP PEL NL
Sbjct: 95 PEIPESISFCKALQVADFSGNPLTRLPESFPELQNL 130
Score = 44.7 bits (104), Expect = 7e-05
Identities = 24/68 (35%), Positives = 33/68 (48%)
Query: 79 YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 138
Y +L L L N LP +L KL+ L L DN++ LP EI QL EL + N
Sbjct: 34 YARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVELDVSRNE 93
Query: 139 LTVLPPEL 146
+ +P +
Sbjct: 94 IPEIPESI 101
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 98.2 bits (243), Expect = 5e-21
Identities = 67/174 (38%), Positives = 86/174 (49%), Gaps = 23/174 (13%)
Query: 10 KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLS 69
K LE L NQIEELP Q+ + Q L L+L N L TLP +L L LD++ N +
Sbjct: 46 KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ 105
Query: 70 E---------------------NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 108
E + LP F L L LYL+D E LP + G+LTKLQI
Sbjct: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
Query: 109 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAEN 162
L LR+N L LPK + LTQL+ L + N T +P L L+G K+ + N
Sbjct: 166 LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE--QLSGLKEFWMDAN 217
Score = 89.7 bits (221), Expect = 2e-18
Identities = 50/143 (34%), Positives = 81/143 (56%), Gaps = 2/143 (1%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
MV I+ +NL+ L +N +++LP I SL+ + L + N+L LP G L ++E
Sbjct: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
LD ++N + +LP + LT LR N + LPP+IG + +L L N L +LP
Sbjct: 304 LDCSFNEVE--ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLP 361
Query: 121 KEIGELTQLKELHIQGNRLTVLP 143
+E+G++ +LK +++ NRL LP
Sbjct: 362 EEMGDMQKLKVINLSDNRLKNLP 384
Score = 88.6 bits (218), Expect = 4e-18
Identities = 52/148 (35%), Positives = 82/148 (55%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +IA L NL L+ N I+E P I + + L + +N ++ LP GF L L +
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQL--LNLT 141
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N+ LP NF LT L+ L L +N ++LP + +LT+L+ L L N+ +P+
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
+ +L+ LKE + NRLT +P +G+L
Sbjct: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSL 229
Score = 79.3 bits (194), Expect = 2e-15
Identities = 52/148 (35%), Positives = 73/148 (49%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I LK L L+ N IE + IS+ + L+ L L N L LP GSL + L
Sbjct: 222 IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTL 281
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+ N L LP + L ++ L S N+ E LP IG+LT L+ + N L LP
Sbjct: 282 KIDENQLMY--LPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPP 339
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
EIG + L + N+L LP E+G++
Sbjct: 340 EIGSWKNITVLFLHSNKLETLPEEMGDM 367
Score = 77.8 bits (190), Expect = 7e-15
Identities = 54/169 (31%), Positives = 77/169 (45%), Gaps = 21/169 (12%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
M+P + L LE L+ +N+ E+P + L LK + NRL +P GSL L
Sbjct: 175 MLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTY 234
Query: 61 LDLTYNN------------------LSENSL---PGNFFYLTTLRALYLSDNDFEILPPD 99
LD++ NN LS NSL P L + L + +N LP
Sbjct: 235 LDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDS 294
Query: 100 IGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 148
IG L ++ L N++ +LP IG+LT L+ N L LPPE+G+
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGS 343
Score = 67.4 bits (163), Expect = 9e-12
Identities = 53/169 (31%), Positives = 71/169 (42%), Gaps = 21/169 (12%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P ++L NL L + +E LP L KL+ L L N+L LP+ L LE L
Sbjct: 130 LPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERL 189
Query: 62 DLTYNNLSE---------------------NSLPGNFFYLTTLRALYLSDNDFEILPPDI 100
DL N +E +PG L L L +S N+ E++ I
Sbjct: 190 DLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGI 249
Query: 101 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
LQ L L N L LP+ IG L + L I N+L LP +G L
Sbjct: 250 STCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGL 298
Score = 55.1 bits (131), Expect = 5e-08
Identities = 38/115 (33%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 60 VLDLTYNNLSENSLPGNFF-YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 118
V L Y++ S +P F + TL LYL N E LP + L LSL DNDL +
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 119 LPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQF 173
LP I L L+EL + N + P + N + + +A NP ++ + D F
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVL---TIVEASVNP-ISKLPDGF 134
Score = 52.8 bits (125), Expect = 2e-07
Identities = 27/65 (41%), Positives = 38/65 (58%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+PP I KN+ VL +N++E LP ++ +QKLK +NL NRL LP F L L +
Sbjct: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396
Query: 62 DLTYN 66
L+ N
Sbjct: 397 WLSDN 401
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 98.2 bits (243), Expect = 5e-21
Identities = 67/174 (38%), Positives = 86/174 (49%), Gaps = 23/174 (13%)
Query: 10 KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLS 69
K LE L NQIEELP Q+ + Q L L+L N L TLP +L L LD++ N +
Sbjct: 46 KTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQ 105
Query: 70 E---------------------NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 108
E + LP F L L LYL+D E LP + G+LTKLQI
Sbjct: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
Query: 109 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAEN 162
L LR+N L LPK + LTQL+ L + N T +P L L+G K+ + N
Sbjct: 166 LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLE--QLSGLKEFWMDAN 217
Score = 89.7 bits (221), Expect = 2e-18
Identities = 50/143 (34%), Positives = 81/143 (56%), Gaps = 2/143 (1%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
MV I+ +NL+ L +N +++LP I SL+ + L + N+L LP G L ++E
Sbjct: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
LD ++N + +LP + LT LR N + LPP+IG + +L L N L +LP
Sbjct: 304 LDCSFNEVE--ALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLP 361
Query: 121 KEIGELTQLKELHIQGNRLTVLP 143
+E+G++ +LK +++ NRL LP
Sbjct: 362 EEMGDMQKLKVINLSDNRLKNLP 384
Score = 88.6 bits (218), Expect = 4e-18
Identities = 52/148 (35%), Positives = 82/148 (55%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +IA L NL L+ N I+E P I + + L + +N ++ LP GF L L +
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQL--LNLT 141
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N+ LP NF LT L+ L L +N ++LP + +LT+L+ L L N+ +P+
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPE 201
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
+ +L+ LKE + NRLT +P +G+L
Sbjct: 202 VLEQLSGLKEFWMDANRLTFIPGFIGSL 229
Score = 79.3 bits (194), Expect = 2e-15
Identities = 52/148 (35%), Positives = 73/148 (49%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I LK L L+ N IE + IS+ + L+ L L N L LP GSL + L
Sbjct: 222 IPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTL 281
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+ N L LP + L ++ L S N+ E LP IG+LT L+ + N L LP
Sbjct: 282 KIDENQLMY--LPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPP 339
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
EIG + L + N+L LP E+G++
Sbjct: 340 EIGSWKNITVLFLHSNKLETLPEEMGDM 367
Score = 77.8 bits (190), Expect = 7e-15
Identities = 54/169 (31%), Positives = 77/169 (45%), Gaps = 21/169 (12%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
M+P + L LE L+ +N+ E+P + L LK + NRL +P GSL L
Sbjct: 175 MLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTY 234
Query: 61 LDLTYNN------------------LSENSL---PGNFFYLTTLRALYLSDNDFEILPPD 99
LD++ NN LS NSL P L + L + +N LP
Sbjct: 235 LDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDS 294
Query: 100 IGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 148
IG L ++ L N++ +LP IG+LT L+ N L LPPE+G+
Sbjct: 295 IGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGS 343
Score = 67.4 bits (163), Expect = 9e-12
Identities = 53/169 (31%), Positives = 71/169 (42%), Gaps = 21/169 (12%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P ++L NL L + +E LP L KL+ L L N+L LP+ L LE L
Sbjct: 130 LPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERL 189
Query: 62 DLTYNNLSE---------------------NSLPGNFFYLTTLRALYLSDNDFEILPPDI 100
DL N +E +PG L L L +S N+ E++ I
Sbjct: 190 DLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGI 249
Query: 101 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
LQ L L N L LP+ IG L + L I N+L LP +G L
Sbjct: 250 STCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGL 298
Score = 55.1 bits (131), Expect = 5e-08
Identities = 38/115 (33%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 60 VLDLTYNNLSENSLPGNFF-YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 118
V L Y++ S +P F + TL LYL N E LP + L LSL DNDL +
Sbjct: 24 VTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTT 83
Query: 119 LPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQF 173
LP I L L+EL + N + P + N + + +A NP ++ + D F
Sbjct: 84 LPASIANLINLRELDVSKNGIQEFPENIKNCKVL---TIVEASVNP-ISKLPDGF 134
Score = 52.8 bits (125), Expect = 2e-07
Identities = 27/65 (41%), Positives = 38/65 (58%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+PP I KN+ VL +N++E LP ++ +QKLK +NL NRL LP F L L +
Sbjct: 337 LPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAM 396
Query: 62 DLTYN 66
L+ N
Sbjct: 397 WLSDN 401
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 98.2 bits (243), Expect = 5e-21
Identities = 57/148 (38%), Positives = 83/148 (56%), Gaps = 2/148 (1%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
++P +I EL L L ++N+++ LP ++ L L L L N L +LP +L L +
Sbjct: 114 ILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRM 173
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
LDL +N L E +P + L +L LYL N + DI L+KL +LS+R+N + LP
Sbjct: 174 LDLRHNKLRE--IPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLP 231
Query: 121 KEIGELTQLKELHIQGNRLTVLPPELGN 148
EIGEL L L + N+L LP E+GN
Sbjct: 232 AEIGELCNLITLDVAHNQLEHLPKEIGN 259
Score = 90.9 bits (224), Expect = 8e-19
Identities = 63/164 (38%), Positives = 83/164 (50%), Gaps = 6/164 (3%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P + ++ LN NQ+ ++P +S L L+ L L N L LP G G+L L L
Sbjct: 394 LPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLREL 453
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
DL N L SLP YL L+ L L++N LP IG LT L L L +N L LP+
Sbjct: 454 DLEENKLE--SLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPE 511
Query: 122 EIGELTQLKELHIQGN-RLTVLPPELGNLDLTGQKQVFKAENNP 164
EIG L L+EL++ N L LP EL L + + EN P
Sbjct: 512 EIGTLENLEELYLNDNPNLHSLPFELA---LCSKLSIMSIENCP 552
Score = 87.4 bits (215), Expect = 9e-18
Identities = 57/141 (40%), Positives = 74/141 (52%), Gaps = 2/141 (1%)
Query: 10 KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLS 69
K L LN +NQ+ LP + + LNL N+L +P L +LEVL L+ N L
Sbjct: 379 KVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLK 438
Query: 70 ENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQL 129
+ LP L LR L L +N E LP +I L LQ L L +N L +LP+ IG LT L
Sbjct: 439 K--LPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNL 496
Query: 130 KELHIQGNRLTVLPPELGNLD 150
L + N LT LP E+G L+
Sbjct: 497 THLGLGENLLTHLPEEIGTLE 517
Score = 84.0 bits (206), Expect = 1e-16
Identities = 55/146 (37%), Positives = 86/146 (58%), Gaps = 3/146 (2%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +++ L +LEVL NN +++LP + +L+KL+ L+L N+L +LP L L+ L
Sbjct: 417 IPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKL 476
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDN-DLISLP 120
LT N L+ +LP +LT L L L +N LP +IG L L+ L L DN +L SLP
Sbjct: 477 VLTNNQLT--TLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLP 534
Query: 121 KEIGELTQLKELHIQGNRLTVLPPEL 146
E+ ++L + I+ L+ LPP++
Sbjct: 535 FELALCSKLSIMSIENCPLSHLPPQI 560
Score = 83.6 bits (205), Expect = 1e-16
Identities = 47/145 (32%), Positives = 79/145 (54%), Gaps = 2/145 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P ++ LK L +L+ +N++ E+P+ + L L L L NR+ T+ + +L L +L
Sbjct: 161 LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSML 220
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+ N + + LP L L L ++ N E LP +IG T++ L L+ N+L+ LP
Sbjct: 221 SIRENKIKQ--LPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPD 278
Query: 122 EIGELTQLKELHIQGNRLTVLPPEL 146
IG L+ L L ++ NRL+ +P L
Sbjct: 279 TIGNLSSLSRLGLRYNRLSAIPRSL 303
Score = 73.6 bits (179), Expect = 1e-13
Identities = 46/145 (31%), Positives = 73/145 (50%), Gaps = 2/145 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P + L +L L N+I + I +L KL L++ N++ LP G L L L
Sbjct: 184 IPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITL 243
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
D+ +N L LP T + L L N+ LP IG L+ L L LR N L ++P+
Sbjct: 244 DVAHNQLEH--LPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPR 301
Query: 122 EIGELTQLKELHIQGNRLTVLPPEL 146
+ + + L+EL+++ N ++ LP L
Sbjct: 302 SLAKCSALEELNLENNNISTLPESL 326
Score = 72.4 bits (176), Expect = 3e-13
Identities = 53/151 (35%), Positives = 73/151 (48%), Gaps = 5/151 (3%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQI-SSLQKLKHLNLGMNRLNTLPRGFGS-LPALE 59
+P ++A+ LE LN NN I LP + SSL KL L L N P G S +
Sbjct: 299 IPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIY 358
Query: 60 VLDLTYNNLSENSLP-GNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 118
L++ +N + N +P G F L L + DN LP D G T + L+L N L
Sbjct: 359 SLNMEHNRI--NKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTK 416
Query: 119 LPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
+P+++ L L+ L + N L LP LGNL
Sbjct: 417 IPEDVSGLVSLEVLILSNNLLKKLPHGLGNL 447
Score = 55.1 bits (131), Expect = 5e-08
Identities = 32/90 (35%), Positives = 50/90 (55%), Gaps = 2/90 (2%)
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
LDL+ ++ + LP + LT L LYL N + LP ++G L L L+L +N L SLP
Sbjct: 105 LDLSKRSI--HILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLP 162
Query: 121 KEIGELTQLKELHIQGNRLTVLPPELGNLD 150
+ L +L+ L ++ N+L +P + LD
Sbjct: 163 DSLDNLKKLRMLDLRHNKLREIPSVVYRLD 192
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 97.8 bits (242), Expect = 7e-21
Identities = 66/182 (36%), Positives = 88/182 (48%), Gaps = 24/182 (13%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+PP + L+ L L+ N++EELP ++ L L L L N L LP G G L L +L
Sbjct: 212 LPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSIL 271
Query: 62 DLTYNNLSE---------------------NSLPGNFFYLTTLRALYLSDNDFEILPPDI 100
+ N L E +LP + LT L L + N E LPP+I
Sbjct: 272 KVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Query: 101 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKA 160
G L +LSLRDN L LP E+ T+L L + GNRL LP L +L+L K ++ A
Sbjct: 332 GGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNL---KALWLA 388
Query: 161 EN 162
EN
Sbjct: 389 EN 390
Score = 93.2 bits (230), Expect = 2e-19
Identities = 60/150 (40%), Positives = 78/150 (52%), Gaps = 2/150 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +I K LE+ +F N + LP + L+ L HL L L LP G+L L L
Sbjct: 97 IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL 156
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+L N L SLP + +L L L L ND E+LP +G L L+ L L N L +LP
Sbjct: 157 ELRENLLK--SLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPP 214
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDL 151
E+G L +L L + NRL LP ELG L L
Sbjct: 215 ELGNLRRLVCLDVSENRLEELPAELGGLVL 244
Score = 92.0 bits (227), Expect = 4e-19
Identities = 58/148 (39%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+PP +A L L+ N I E+P I + L+ + N L+ LP GF L +L L
Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N++S +LPG+ L L L L +N + LP + L KL+ L L NDL LP
Sbjct: 134 AL--NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPD 191
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
+G L L+EL + N+L+ LPPELGNL
Sbjct: 192 TLGALPNLRELWLDRNQLSALPPELGNL 219
Score = 89.7 bits (221), Expect = 2e-18
Identities = 54/148 (36%), Positives = 79/148 (53%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P L NL L +N+I+ LP ++++ +L L++ N + +P ALE+
Sbjct: 51 LPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIA 110
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
D + N LS LP F L +L L L+D + LP D+G L L L LR+N L SLP
Sbjct: 111 DFSGNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPA 168
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
+ L +L++L + GN L VLP LG L
Sbjct: 169 SLSFLVKLEQLDLGGNDLEVLPDTLGAL 196
Score = 83.6 bits (205), Expect = 1e-16
Identities = 57/149 (38%), Positives = 77/149 (51%), Gaps = 2/149 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P ++ L NL L N ++ LP +S L KL+ L+LG N L LP G+LP L L
Sbjct: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N LS +LP L L L +S+N E LP ++G L L L L N L LP
Sbjct: 203 WLDRNQLS--ALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLD 150
IG+L QL L + NRL + +G+ +
Sbjct: 261 GIGQLKQLSILKVDQNRLCEVTEAIGDCE 289
Score = 80.5 bits (197), Expect = 1e-15
Identities = 55/162 (33%), Positives = 78/162 (48%), Gaps = 5/162 (3%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +L++L L + ++ LP + +L L L L N L +LP L LE L
Sbjct: 120 LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
DL N+L LP L LR L+L N LPP++G L +L L + +N L LP
Sbjct: 180 DLGGNDLEV--LPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPA 237
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENN 163
E+G L L +L + N L LP +G L Q + K + N
Sbjct: 238 ELGGLVLLTDLLLSQNLLRRLPDGIGQLK---QLSILKVDQN 276
Score = 52.4 bits (124), Expect = 3e-07
Identities = 34/87 (39%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 57 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 116
+LE L L N L E LP FF L LR L LSDN+ + LPP++ +L L + ND+
Sbjct: 37 SLEELLLDANQLRE--LPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDI 94
Query: 117 ISLPKEIGELTQLKELHIQGNRLTVLP 143
+P+ I L+ GN L+ LP
Sbjct: 95 PEIPESIKFCKALEIADFSGNPLSRLP 121
Score = 40.8 bits (94), Expect = 0.001
Identities = 22/68 (32%), Positives = 32/68 (47%)
Query: 79 YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 138
Y +L L L N LP +L L+ L L DN++ LP E+ QL EL + N
Sbjct: 34 YSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND 93
Query: 139 LTVLPPEL 146
+ +P +
Sbjct: 94 IPEIPESI 101
Score = 28.1 bits (61), Expect = 6.3
Identities = 16/50 (32%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPR 50
++PP +A L VL+ N+++ LP ++ L LK L L N+ + R
Sbjct: 349 VLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQPMLR 397
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 97.8 bits (242), Expect = 7e-21
Identities = 66/182 (36%), Positives = 88/182 (48%), Gaps = 24/182 (13%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+PP + L+ L L+ N++EELP ++ L L L L N L LP G G L L +L
Sbjct: 212 LPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSIL 271
Query: 62 DLTYNNLSE---------------------NSLPGNFFYLTTLRALYLSDNDFEILPPDI 100
+ N L E +LP + LT L L + N E LPP+I
Sbjct: 272 KVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEI 331
Query: 101 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKA 160
G L +LSLRDN L LP E+ T+L L + GNRL LP L +L+L K ++ A
Sbjct: 332 GGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNL---KALWLA 388
Query: 161 EN 162
EN
Sbjct: 389 EN 390
Score = 93.2 bits (230), Expect = 2e-19
Identities = 60/150 (40%), Positives = 78/150 (52%), Gaps = 2/150 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +I K LE+ +F N + LP + L+ L HL L L LP G+L L L
Sbjct: 97 IPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTL 156
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+L N L SLP + +L L L L ND E+LP +G L L+ L L N L +LP
Sbjct: 157 ELRENLLK--SLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPP 214
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDL 151
E+G L +L L + NRL LP ELG L L
Sbjct: 215 ELGNLRRLVCLDVSENRLEELPAELGGLVL 244
Score = 92.0 bits (227), Expect = 4e-19
Identities = 58/148 (39%), Positives = 80/148 (54%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+PP +A L L+ N I E+P I + L+ + N L+ LP GF L +L L
Sbjct: 74 LPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHL 133
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N++S +LPG+ L L L L +N + LP + L KL+ L L NDL LP
Sbjct: 134 AL--NDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPD 191
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
+G L L+EL + N+L+ LPPELGNL
Sbjct: 192 TLGALPNLRELWLDRNQLSALPPELGNL 219
Score = 89.7 bits (221), Expect = 2e-18
Identities = 54/148 (36%), Positives = 79/148 (53%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P L NL L +N+I+ LP ++++ +L L++ N + +P ALE+
Sbjct: 51 LPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIA 110
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
D + N LS LP F L +L L L+D + LP D+G L L L LR+N L SLP
Sbjct: 111 DFSGNPLSR--LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPA 168
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
+ L +L++L + GN L VLP LG L
Sbjct: 169 SLSFLVKLEQLDLGGNDLEVLPDTLGAL 196
Score = 83.6 bits (205), Expect = 1e-16
Identities = 57/149 (38%), Positives = 77/149 (51%), Gaps = 2/149 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P ++ L NL L N ++ LP +S L KL+ L+LG N L LP G+LP L L
Sbjct: 143 LPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLREL 202
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N LS +LP L L L +S+N E LP ++G L L L L N L LP
Sbjct: 203 WLDRNQLS--ALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPD 260
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLD 150
IG+L QL L + NRL + +G+ +
Sbjct: 261 GIGQLKQLSILKVDQNRLCEVTEAIGDCE 289
Score = 80.5 bits (197), Expect = 1e-15
Identities = 55/162 (33%), Positives = 78/162 (48%), Gaps = 5/162 (3%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +L++L L + ++ LP + +L L L L N L +LP L LE L
Sbjct: 120 LPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
DL N+L LP L LR L+L N LPP++G L +L L + +N L LP
Sbjct: 180 DLGGNDLEV--LPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPA 237
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENN 163
E+G L L +L + N L LP +G L Q + K + N
Sbjct: 238 ELGGLVLLTDLLLSQNLLRRLPDGIGQLK---QLSILKVDQN 276
Score = 52.4 bits (124), Expect = 3e-07
Identities = 34/87 (39%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 57 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 116
+LE L L N L E LP FF L LR L LSDN+ + LPP++ +L L + ND+
Sbjct: 37 SLEELLLDANQLRE--LPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDI 94
Query: 117 ISLPKEIGELTQLKELHIQGNRLTVLP 143
+P+ I L+ GN L+ LP
Sbjct: 95 PEIPESIKFCKALEIADFSGNPLSRLP 121
Score = 40.8 bits (94), Expect = 0.001
Identities = 22/68 (32%), Positives = 32/68 (47%)
Query: 79 YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 138
Y +L L L N LP +L L+ L L DN++ LP E+ QL EL + N
Sbjct: 34 YSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRND 93
Query: 139 LTVLPPEL 146
+ +P +
Sbjct: 94 IPEIPESI 101
Score = 28.1 bits (61), Expect = 6.3
Identities = 16/50 (32%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPR 50
++PP +A L VL+ N+++ LP ++ L LK L L N+ + R
Sbjct: 349 VLPPELAHTTELHVLDVAGNRLQSLPFALTHL-NLKALWLAENQAQPMLR 397
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 95.1 bits (235), Expect = 4e-20
Identities = 65/198 (32%), Positives = 99/198 (50%), Gaps = 4/198 (2%)
Query: 3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLD 62
P I LKNLEVL +N+I +LP+++ SL KLK L L N + P SL +LE L
Sbjct: 319 PLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLY 378
Query: 63 LTYNN-LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+ + +P + L +L+ LY+ +N E LP +G + L++L R N L LP
Sbjct: 379 IGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPD 438
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVF 181
I + LKEL ++ N LT LP NLD +V +NP P + G ++
Sbjct: 439 AICQAQALKELRLEDNLLTHLPE---NLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIW 495
Query: 182 EYIRSETYKYLYGRHMQA 199
+Y++ + + +QA
Sbjct: 496 KYLKENRNRNIMATKIQA 513
Score = 87.0 bits (214), Expect = 1e-17
Identities = 58/146 (39%), Positives = 82/146 (56%), Gaps = 2/146 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I LE ++ NNQIEE+P +I L+ ++ L L N L +L G L +LE L
Sbjct: 40 IPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESL 99
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGK-LTKLQILSLRDNDLISLP 120
DL+YN + +SL F L LR L L D + +P I K L L++L L N L LP
Sbjct: 100 DLSYNPIFSSSLVVVSF-LHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLP 158
Query: 121 KEIGELTQLKELHIQGNRLTVLPPEL 146
KEI T+L+E++++ N+ V P EL
Sbjct: 159 KEIVNQTKLREIYLKRNQFEVFPQEL 184
Score = 79.7 bits (195), Expect = 2e-15
Identities = 43/135 (31%), Positives = 75/135 (55%), Gaps = 2/135 (1%)
Query: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
L +LE+L N ++ LP +I + KL+ + L N+ P+ L LE++DL N +
Sbjct: 141 LHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKI 200
Query: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
++P +LT L+ Y++ N+ +LP + + ++L +L L N L S+PK EL +
Sbjct: 201 G--AIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRK 258
Query: 129 LKELHIQGNRLTVLP 143
+ E+ + GNRL +P
Sbjct: 259 MTEIGLSGNRLEKVP 273
Score = 79.7 bits (195), Expect = 2e-15
Identities = 54/164 (32%), Positives = 81/164 (49%), Gaps = 7/164 (4%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
++P ++ + L VL+ +N + +P + L+K+ + L NRL +PR +L +
Sbjct: 225 VLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHL 284
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
L L N + L G+F L LR L LS N P I L L++L L DN + LP
Sbjct: 285 LYL--GNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLP 342
Query: 121 KEIGELTQLKELHIQGNRLTVLPPELGNLD-----LTGQKQVFK 159
E+G L++LK L + GN P E+ +L GQ Q FK
Sbjct: 343 SELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFK 386
Score = 55.5 bits (132), Expect = 4e-08
Identities = 39/122 (31%), Positives = 57/122 (46%), Gaps = 25/122 (20%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
VP +I +L++L+ L NN +E LP + GS+P LEVL
Sbjct: 390 VPEHIRKLQSLKELYIENNHLEYLPVSL-----------------------GSMPNLEVL 426
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
D +N L + LP L+ L L DN LP ++ L L++L+L DN + PK
Sbjct: 427 DCRHNLLKQ--LPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPK 484
Query: 122 EI 123
E+
Sbjct: 485 EV 486
Score = 31.6 bits (70), Expect = 0.57
Identities = 12/37 (32%), Positives = 24/37 (64%)
Query: 113 DNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
+ L ++P EI T+L+E+H++ N++ +P E+ L
Sbjct: 34 NQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRL 70
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 95.1 bits (235), Expect = 4e-20
Identities = 63/187 (33%), Positives = 100/187 (53%), Gaps = 8/187 (4%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
VP + + L +L LN +N+++ LP +I+ +++LKHL+ N L T+P + +LE+L
Sbjct: 189 VPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELL 248
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPD-IGKLTKLQILSLRDNDLISLP 120
L N L LP F + L+ L++ +N E+L + + L + +L LRDN L S+P
Sbjct: 249 YLRRNKL--RFLP-EFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVP 305
Query: 121 KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHV 180
EI L L+ L + N ++ LP LGNL L + E NP T + G V
Sbjct: 306 DEIILLRSLERLDLSNNDISSLPYSLGNLHL----KFLALEGNPLRTIRREIISKGTQEV 361
Query: 181 FEYIRSE 187
+Y+RS+
Sbjct: 362 LKYLRSK 368
Score = 90.1 bits (222), Expect = 1e-18
Identities = 52/142 (36%), Positives = 88/142 (61%), Gaps = 2/142 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I EL+NL+ LN +N+++ LP +I++L+ LK L L N L + GF L LE L
Sbjct: 120 LPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDL 179
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
DL+ N+L+ ++P +F L++L L LS N+ + LP +I ++ +L+ L N L ++P
Sbjct: 180 DLSNNHLT--TVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPP 237
Query: 122 EIGELTQLKELHIQGNRLTVLP 143
E+ + L+ L+++ N+L LP
Sbjct: 238 ELAGMESLELLYLRRNKLRFLP 259
Score = 83.6 bits (205), Expect = 1e-16
Identities = 51/142 (35%), Positives = 75/142 (52%), Gaps = 2/142 (1%)
Query: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
L L VL+ +NQ+ LP+ I L+ L+ LN+ N+L LP +L L+ L L +N L
Sbjct: 104 LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNEL 163
Query: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
+ + F L+ L L LS+N +P L+ L L+L N+L SLP EI + +
Sbjct: 164 T--CISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKR 221
Query: 129 LKELHIQGNRLTVLPPELGNLD 150
LK L N L +PPEL ++
Sbjct: 222 LKHLDCNSNLLETIPPELAGME 243
Score = 67.4 bits (163), Expect = 9e-12
Identities = 43/142 (30%), Positives = 75/142 (52%), Gaps = 4/142 (2%)
Query: 2 VPPNIAELKNL-EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
+P + ELK + ++ N++ + ++ LQKL L+L N LN+LP SL L+
Sbjct: 440 IPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQT 499
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK-LQILSLRDNDLISL 119
++L++N LP + + TL + +S+N + P K+ + L L L++NDL+ +
Sbjct: 500 INLSFNRF--KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQI 557
Query: 120 PKEIGELTQLKELHIQGNRLTV 141
P E+G L+ L + GN V
Sbjct: 558 PPELGNCVNLRTLLLDGNPFRV 579
Score = 65.5 bits (158), Expect = 4e-11
Identities = 41/142 (28%), Positives = 69/142 (48%), Gaps = 2/142 (1%)
Query: 8 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 67
E +L L NN+++ L + L L L++ N+L +LP L L+ L++++N
Sbjct: 80 EQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNK 139
Query: 68 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 127
L LP L L+ LYL N+ + +L+ L+ L L +N L ++P L+
Sbjct: 140 L--KILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLS 197
Query: 128 QLKELHIQGNRLTVLPPELGNL 149
L L++ N L LP E+ +
Sbjct: 198 SLVRLNLSSNELKSLPAEINRM 219
Score = 57.0 bits (136), Expect = 1e-08
Identities = 37/121 (30%), Positives = 64/121 (52%), Gaps = 2/121 (1%)
Query: 29 ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYL 88
+ + +K LNL L+ +P+ + +++ + NLS + ++ T L L +
Sbjct: 32 LKAARKSGQLNLSGRNLSEVPQCVWRIN-VDIPEEANQNLSFGATE-RWWEQTDLTKLII 89
Query: 89 SDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 148
S+N + L D+ L L +L + DN L SLP I EL L++L++ N+L +LP E+ N
Sbjct: 90 SNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITN 149
Query: 149 L 149
L
Sbjct: 150 L 150
Score = 55.1 bits (131), Expect = 5e-08
Identities = 53/209 (25%), Positives = 89/209 (42%), Gaps = 33/209 (15%)
Query: 5 NIAELKNLEVLNFFNNQIEELPTQISSLQK---LKHLNLGMNRLNTLPRGFGSLPAL-EV 60
NI + L++L++ + Q +P ++ K + +N N+L +P+ L +
Sbjct: 394 NIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSD 453
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
+DL++N LS SL L L L L +N LP ++ L +LQ ++L N LP
Sbjct: 454 VDLSFNKLSFISL--ELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLP 511
Query: 121 K----------------EIGE--------LTQLKELHIQGNRLTVLPPELGNLDLTGQKQ 156
+ ++G + L L +Q N L +PPELGN +
Sbjct: 512 EVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGN---CVNLR 568
Query: 157 VFKAENNPWVTPIADQFQLGVSHVFEYIR 185
+ NP+ P A G + + EY+R
Sbjct: 569 TLLLDGNPFRVPRAAILMKGTAAILEYLR 597
Score = 47.4 bits (111), Expect = 1e-05
Identities = 37/98 (37%), Positives = 49/98 (50%), Gaps = 6/98 (6%)
Query: 59 EVLDLTYNNLSEN---SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDND 115
E DLT +S N SL + L L L + DN LP I +L LQ L++ N
Sbjct: 80 EQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNK 139
Query: 116 LISLPKEIGELTQLKELHIQGNRLTVLP---PELGNLD 150
L LP+EI L LK L++Q N LT + +L NL+
Sbjct: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLE 177
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 94.7 bits (234), Expect = 6e-20
Identities = 72/237 (30%), Positives = 109/237 (45%), Gaps = 55/237 (23%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
VP + +LE+LN ++N I +P I +LQ L +LNL N+L+ LP LP
Sbjct: 112 VPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLCGLP----- 166
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L+ L S+N LP +IG+L +L L + N++ +LP+
Sbjct: 167 ---------------------LKVLIASNNKLGSLPEEIGQLKQLMELDVSCNEITALPQ 205
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDLT-------------------GQKQVFKAEN 162
+IG+L L+EL+++ N L VLP EL +L L Q QV EN
Sbjct: 206 QIGQLKSLRELNVRRNYLKVLPQELVDLPLVKFDFSCNKVLVIPICFREMKQLQVLLLEN 265
Query: 163 NPWVTPIADQFQLGVSHVFEY-------IRSETYKYLYGR---HMQANPEPPKKNND 209
NP +P A G H+F+Y I++ YL+ H+ + E KK++D
Sbjct: 266 NPLQSPPAQICTKGKVHIFKYLSIQACQIKTADSLYLHTMERPHLHQHVEDGKKDSD 322
Score = 33.9 bits (76), Expect = 0.12
Identities = 25/76 (32%), Positives = 38/76 (50%), Gaps = 4/76 (5%)
Query: 88 LSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELG 147
LS N +P ++ L+IL+L N + +P+ I L L L++ N+L+ LP L
Sbjct: 104 LSKNRLVEVPMELCHFVSLEILNLYHNCIRVIPEAIVNLQMLTYLNLSRNQLSALPACLC 163
Query: 148 NLDLTGQKQVFKAENN 163
L L +V A NN
Sbjct: 164 GLPL----KVLIASNN 175
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 94.4 bits (233), Expect = 7e-20
Identities = 65/183 (35%), Positives = 100/183 (54%), Gaps = 7/183 (3%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P ++ LE LN ++N I+ +P I +LQ L +LN+ N L+TLP+ LP L+VL
Sbjct: 126 IPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLP-LKVL 184
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
++ N L S+P L L L +S N+ ++LP +GKL L+ L++R N+L LP
Sbjct: 185 VVSNNKLV--SIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPD 242
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVF 181
E+G+L +K L N++T +P L QV +NNP P A G H+F
Sbjct: 243 ELGDLPLVK-LDFSCNKVTEIPVCYRKLH---HLQVIILDNNPLQVPPAQICLKGKVHIF 298
Query: 182 EYI 184
+Y+
Sbjct: 299 KYL 301
Score = 44.3 bits (103), Expect = 9e-05
Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 6/123 (4%)
Query: 45 LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT 104
+ +L R + +L L+ L + PG+ + LT LS N F +P D+
Sbjct: 77 VRSLDRALEEAGSSGILSLSGRKLRD--FPGSGYDLTDTTQADLSRNRFTEIPSDVWLFA 134
Query: 105 KLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNP 164
L+ L+L N + ++P+ I L L L+I N L+ LP L +L L +V NN
Sbjct: 135 PLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPL----KVLVVSNNK 190
Query: 165 WVT 167
V+
Sbjct: 191 LVS 193
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 94.0 bits (232), Expect = 9e-20
Identities = 58/147 (39%), Positives = 82/147 (55%), Gaps = 4/147 (2%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I L NLE L N+IE++PTQ+ +KL++L+L N L LP G L L+ L
Sbjct: 654 IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNL 713
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+T N + +LP F LRAL+L +N + LP +G+LT L + LR N L LP
Sbjct: 714 AITANRI--ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPV 771
Query: 122 EIGELTQLKE--LHIQGNRLTVLPPEL 146
E+GE LK L ++ + LPPE+
Sbjct: 772 ELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 92.8 bits (229), Expect = 2e-19
Identities = 55/143 (38%), Positives = 79/143 (55%), Gaps = 2/143 (1%)
Query: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
L L L + N I +P QI +L L+ L L N++ +P L LDL++NNL
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
+ LP + L L+ L ++ N E LPP++ + KL+ L L +N L SLP +GELT
Sbjct: 698 T--FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTN 755
Query: 129 LKELHIQGNRLTVLPPELGNLDL 151
L ++ ++GNRL LP ELG L
Sbjct: 756 LTQIELRGNRLECLPVELGECPL 778
Score = 55.1 bits (131), Expect = 5e-08
Identities = 51/174 (29%), Positives = 75/174 (43%), Gaps = 26/174 (14%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMNR------------ 44
+V + ELK L+VL +N + +LP ++ LQKL N G
Sbjct: 535 IVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANL 593
Query: 45 ---------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEI 95
L +P SL L+ +DL NNL +F +L L L L N
Sbjct: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAY 653
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
+P IG LT L+ L L N + +P ++ +L+ L + N LT LP ++G L
Sbjct: 654 IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLL 707
Score = 41.2 bits (95), Expect = 7e-04
Identities = 50/176 (28%), Positives = 76/176 (43%), Gaps = 30/176 (17%)
Query: 4 PNIAELK-NLEVLNFFNNQIEELPTQISSLQKLKHLNL-----GMNRLNTLPRGFGSLPA 57
P +A L+ NL L+ I+E+P I SL+ L+ L+L N + G L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKR 545
Query: 58 LEVLDLTYN----------------NLSENSLPGNFFYLTTLR------ALYLSDNDFEI 95
L+VL L N LS N+ L +L+ L L D E
Sbjct: 546 LKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLER 605
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIG--ELTQLKELHIQGNRLTVLPPELGNL 149
+P I L LQ + L+DN+L ++ + I L +L L + N + +P ++GNL
Sbjct: 606 IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661
Score = 38.1 bits (87), Expect = 0.006
Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 3/101 (2%)
Query: 38 LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILP 97
L L + L+ +P L LEVL L + + ++P + LT L+ L+L +I
Sbjct: 428 LELHLFMLSGIPDTVFDLVELEVLKLEL--IPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 98 PDIGKLTK-LQILSLRDNDLISLPKEIGELTQLKELHIQGN 137
P + L + L+ L ++ D+ +P I L L+ELH+ GN
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN 526
Score = 28.9 bits (63), Expect = 3.7
Identities = 16/54 (29%), Positives = 27/54 (50%)
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
+P + L +L++L L +++P I +LT LKEL + + P L L
Sbjct: 438 IPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFL 491
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 94.0 bits (232), Expect = 9e-20
Identities = 58/147 (39%), Positives = 82/147 (55%), Gaps = 4/147 (2%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I L NLE L N+IE++PTQ+ +KL++L+L N L LP G L L+ L
Sbjct: 654 IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNL 713
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+T N + +LP F LRAL+L +N + LP +G+LT L + LR N L LP
Sbjct: 714 AITANRI--ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPV 771
Query: 122 EIGELTQLKE--LHIQGNRLTVLPPEL 146
E+GE LK L ++ + LPPE+
Sbjct: 772 ELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 92.8 bits (229), Expect = 2e-19
Identities = 55/143 (38%), Positives = 79/143 (55%), Gaps = 2/143 (1%)
Query: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
L L L + N I +P QI +L L+ L L N++ +P L LDL++NNL
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
+ LP + L L+ L ++ N E LPP++ + KL+ L L +N L SLP +GELT
Sbjct: 698 T--FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTN 755
Query: 129 LKELHIQGNRLTVLPPELGNLDL 151
L ++ ++GNRL LP ELG L
Sbjct: 756 LTQIELRGNRLECLPVELGECPL 778
Score = 55.1 bits (131), Expect = 5e-08
Identities = 51/174 (29%), Positives = 75/174 (43%), Gaps = 26/174 (14%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMNR------------ 44
+V + ELK L+VL +N + +LP ++ LQKL N G
Sbjct: 535 IVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANL 593
Query: 45 ---------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEI 95
L +P SL L+ +DL NNL +F +L L L L N
Sbjct: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAY 653
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
+P IG LT L+ L L N + +P ++ +L+ L + N LT LP ++G L
Sbjct: 654 IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLL 707
Score = 41.2 bits (95), Expect = 7e-04
Identities = 50/176 (28%), Positives = 76/176 (43%), Gaps = 30/176 (17%)
Query: 4 PNIAELK-NLEVLNFFNNQIEELPTQISSLQKLKHLNL-----GMNRLNTLPRGFGSLPA 57
P +A L+ NL L+ I+E+P I SL+ L+ L+L N + G L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKR 545
Query: 58 LEVLDLTYN----------------NLSENSLPGNFFYLTTLR------ALYLSDNDFEI 95
L+VL L N LS N+ L +L+ L L D E
Sbjct: 546 LKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLER 605
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIG--ELTQLKELHIQGNRLTVLPPELGNL 149
+P I L LQ + L+DN+L ++ + I L +L L + N + +P ++GNL
Sbjct: 606 IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661
Score = 38.1 bits (87), Expect = 0.006
Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 3/101 (2%)
Query: 38 LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILP 97
L L + L+ +P L LEVL L + + ++P + LT L+ L+L +I
Sbjct: 428 LELHLFMLSGIPDTVFDLVELEVLKLEL--IPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 98 PDIGKLTK-LQILSLRDNDLISLPKEIGELTQLKELHIQGN 137
P + L + L+ L ++ D+ +P I L L+ELH+ GN
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN 526
Score = 28.9 bits (63), Expect = 3.7
Identities = 16/54 (29%), Positives = 27/54 (50%)
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
+P + L +L++L L +++P I +LT LKEL + + P L L
Sbjct: 438 IPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFL 491
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 94.0 bits (232), Expect = 9e-20
Identities = 58/147 (39%), Positives = 82/147 (55%), Gaps = 4/147 (2%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I L NLE L N+IE++PTQ+ +KL++L+L N L LP G L L+ L
Sbjct: 654 IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNL 713
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+T N + +LP F LRAL+L +N + LP +G+LT L + LR N L LP
Sbjct: 714 AITANRI--ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPV 771
Query: 122 EIGELTQLKE--LHIQGNRLTVLPPEL 146
E+GE LK L ++ + LPPE+
Sbjct: 772 ELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 92.8 bits (229), Expect = 2e-19
Identities = 55/143 (38%), Positives = 79/143 (55%), Gaps = 2/143 (1%)
Query: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
L L L + N I +P QI +L L+ L L N++ +P L LDL++NNL
Sbjct: 638 LHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNL 697
Query: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
+ LP + L L+ L ++ N E LPP++ + KL+ L L +N L SLP +GELT
Sbjct: 698 T--FLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTN 755
Query: 129 LKELHIQGNRLTVLPPELGNLDL 151
L ++ ++GNRL LP ELG L
Sbjct: 756 LTQIELRGNRLECLPVELGECPL 778
Score = 55.1 bits (131), Expect = 5e-08
Identities = 51/174 (29%), Positives = 75/174 (43%), Gaps = 26/174 (14%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISS----LQKLKHLNLGMNR------------ 44
+V + ELK L+VL +N + +LP ++ LQKL N G
Sbjct: 535 IVIDGLRELKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANL 593
Query: 45 ---------LNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEI 95
L +P SL L+ +DL NNL +F +L L L L N
Sbjct: 594 TELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAY 653
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
+P IG LT L+ L L N + +P ++ +L+ L + N LT LP ++G L
Sbjct: 654 IPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLL 707
Score = 41.2 bits (95), Expect = 7e-04
Identities = 50/176 (28%), Positives = 76/176 (43%), Gaps = 30/176 (17%)
Query: 4 PNIAELK-NLEVLNFFNNQIEELPTQISSLQKLKHLNL-----GMNRLNTLPRGFGSLPA 57
P +A L+ NL L+ I+E+P I SL+ L+ L+L N + G L
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKR 545
Query: 58 LEVLDLTYN----------------NLSENSLPGNFFYLTTLR------ALYLSDNDFEI 95
L+VL L N LS N+ L +L+ L L D E
Sbjct: 546 LKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLER 605
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIG--ELTQLKELHIQGNRLTVLPPELGNL 149
+P I L LQ + L+DN+L ++ + I L +L L + N + +P ++GNL
Sbjct: 606 IPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNL 661
Score = 38.1 bits (87), Expect = 0.006
Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 3/101 (2%)
Query: 38 LNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILP 97
L L + L+ +P L LEVL L + + ++P + LT L+ L+L +I
Sbjct: 428 LELHLFMLSGIPDTVFDLVELEVLKLEL--IPDVTIPPSIAQLTGLKELWLYHTAAKIEA 485
Query: 98 PDIGKLTK-LQILSLRDNDLISLPKEIGELTQLKELHIQGN 137
P + L + L+ L ++ D+ +P I L L+ELH+ GN
Sbjct: 486 PALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN 526
Score = 28.9 bits (63), Expect = 3.7
Identities = 16/54 (29%), Positives = 27/54 (50%)
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
+P + L +L++L L +++P I +LT LKEL + + P L L
Sbjct: 438 IPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFL 491
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 93.2 bits (230), Expect = 2e-19
Identities = 52/139 (37%), Positives = 84/139 (60%), Gaps = 2/139 (1%)
Query: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
LK L L ++N+I +P I+ ++ L+ L N+L +LP SL L LD++YNN+
Sbjct: 682 LKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNI 741
Query: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
S +P L L+ L+++ N +ILP + K KL+ L+L N + SLP+++G+L+Q
Sbjct: 742 S--MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQ 799
Query: 129 LKELHIQGNRLTVLPPELG 147
L +L ++GN L LP +LG
Sbjct: 800 LTQLELKGNCLDRLPAQLG 818
Score = 79.7 bits (195), Expect = 2e-15
Identities = 48/148 (32%), Positives = 81/148 (54%), Gaps = 4/148 (2%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPR--GFGSLPAL 58
+V ++ ++ N+ L N ++E +P I SL L+ L+L N + T+ F L L
Sbjct: 626 LVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRL 685
Query: 59 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 118
L L +N + ++P + ++ L +LY S+N E LP + L KL+ L + N++
Sbjct: 686 TCLKLWHNKIV--TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
Query: 119 LPKEIGELTQLKELHIQGNRLTVLPPEL 146
+P EIG L L+ LHI GN++ +LP +L
Sbjct: 744 IPIEIGLLQNLQHLHITGNKVDILPKQL 771
Score = 71.6 bits (174), Expect = 5e-13
Identities = 52/158 (32%), Positives = 83/158 (52%), Gaps = 4/158 (2%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQIS--SLQKLKHLNLGMNRLNTLPRGFGSLPALE 59
+P I L NL+ L+ +N I + IS L++L L L N++ T+P + LE
Sbjct: 650 IPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLE 709
Query: 60 VLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISL 119
L + N L SLP F L LR L +S N+ ++P +IG L LQ L + N + L
Sbjct: 710 SLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDIL 767
Query: 120 PKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQV 157
PK++ + +L+ L++ N +T LP ++G L Q ++
Sbjct: 768 PKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL 805
Score = 53.1 bits (126), Expect = 2e-07
Identities = 35/102 (34%), Positives = 54/102 (52%), Gaps = 4/102 (3%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
M+P I L+NL+ L+ N+++ LP Q+ KL+ LNLG N + +LP G L L
Sbjct: 743 MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQ 802
Query: 61 LDLTYNNLSENSLPGNFFYLTTLR--ALYLSDNDFEILPPDI 100
L+L N L + LP L+ L + D+ F+ LP ++
Sbjct: 803 LELKGNCL--DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 93.2 bits (230), Expect = 2e-19
Identities = 52/139 (37%), Positives = 84/139 (60%), Gaps = 2/139 (1%)
Query: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
LK L L ++N+I +P I+ ++ L+ L N+L +LP SL L LD++YNN+
Sbjct: 682 LKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNI 741
Query: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
S +P L L+ L+++ N +ILP + K KL+ L+L N + SLP+++G+L+Q
Sbjct: 742 S--MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQ 799
Query: 129 LKELHIQGNRLTVLPPELG 147
L +L ++GN L LP +LG
Sbjct: 800 LTQLELKGNCLDRLPAQLG 818
Score = 79.7 bits (195), Expect = 2e-15
Identities = 48/148 (32%), Positives = 81/148 (54%), Gaps = 4/148 (2%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPR--GFGSLPAL 58
+V ++ ++ N+ L N ++E +P I SL L+ L+L N + T+ F L L
Sbjct: 626 LVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRL 685
Query: 59 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 118
L L +N + ++P + ++ L +LY S+N E LP + L KL+ L + N++
Sbjct: 686 TCLKLWHNKIV--TIPPSITHVKNLESLYFSNNKLESLPVAVFSLQKLRCLDVSYNNISM 743
Query: 119 LPKEIGELTQLKELHIQGNRLTVLPPEL 146
+P EIG L L+ LHI GN++ +LP +L
Sbjct: 744 IPIEIGLLQNLQHLHITGNKVDILPKQL 771
Score = 71.6 bits (174), Expect = 5e-13
Identities = 52/158 (32%), Positives = 83/158 (52%), Gaps = 4/158 (2%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQIS--SLQKLKHLNLGMNRLNTLPRGFGSLPALE 59
+P I L NL+ L+ +N I + IS L++L L L N++ T+P + LE
Sbjct: 650 IPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLE 709
Query: 60 VLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISL 119
L + N L SLP F L LR L +S N+ ++P +IG L LQ L + N + L
Sbjct: 710 SLYFSNNKLE--SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDIL 767
Query: 120 PKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQV 157
PK++ + +L+ L++ N +T LP ++G L Q ++
Sbjct: 768 PKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQLEL 805
Score = 53.1 bits (126), Expect = 2e-07
Identities = 35/102 (34%), Positives = 54/102 (52%), Gaps = 4/102 (3%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
M+P I L+NL+ L+ N+++ LP Q+ KL+ LNLG N + +LP G L L
Sbjct: 743 MIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCITSLPEKVGQLSQLTQ 802
Query: 61 LDLTYNNLSENSLPGNFFYLTTLR--ALYLSDNDFEILPPDI 100
L+L N L + LP L+ L + D+ F+ LP ++
Sbjct: 803 LELKGNCL--DRLPAQLGQCRMLKKSGLVVEDHLFDTLPLEV 842
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 92.8 bits (229), Expect = 2e-19
Identities = 57/168 (33%), Positives = 88/168 (52%), Gaps = 4/168 (2%)
Query: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
L+NL L ++N I +P QI +L L+ L+L N + LP L LDL+YN+L
Sbjct: 632 LQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691
Query: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
+ +P YL+ L+ +++N+ E+LP + + KLQ L L N L++L +GEL+
Sbjct: 692 T--FIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSN 749
Query: 129 LKELHIQGNRLTVLPPELGNLDLTGQKQVFKAEN--NPWVTPIADQFQ 174
L L + GN L LPPEL + + EN N P+ ++ Q
Sbjct: 750 LTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQ 797
Score = 60.1 bits (144), Expect = 2e-09
Identities = 45/135 (33%), Positives = 63/135 (46%), Gaps = 3/135 (2%)
Query: 29 ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYL 88
+ + LK L L L +P SL L LDL NNL +F +L L L L
Sbjct: 581 LKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKL 640
Query: 89 SDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 148
N+ +P IG L+ L+ LSL N++ +LP ++ T+L L + N LT +P E+
Sbjct: 641 WHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQY 700
Query: 149 LDLTGQKQVFKAENN 163
L Q F NN
Sbjct: 701 L---SNLQYFAVTNN 712
Score = 43.1 bits (100), Expect = 2e-04
Identities = 46/155 (29%), Positives = 75/155 (48%), Gaps = 8/155 (5%)
Query: 2 VPPNIAELKNLEVLNFFNNQI-EELPT-QISSLQKLKHLNLGM--NRLNTLPRGFGSL-P 56
+P + LKNL+ L + E+L T Q+ Q LK+L + L+ +P+ L P
Sbjct: 502 IPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLP 561
Query: 57 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 116
+L+ L L N S+ + N + L++L L D E +P I L L L LR+N+L
Sbjct: 562 SLQKLSLD-NEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNL 620
Query: 117 ISLPKEIG--ELTQLKELHIQGNRLTVLPPELGNL 149
++ + I L L L + N + +P ++G L
Sbjct: 621 KTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGAL 655
Score = 37.4 bits (85), Expect = 0.010
Identities = 19/55 (34%), Positives = 32/55 (58%)
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 150
LP ++ +LT++++LSL + LP + +L LKEL + + L V P L L+
Sbjct: 432 LPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLE 486
Score = 36.6 bits (83), Expect = 0.018
Identities = 42/153 (27%), Positives = 71/153 (46%), Gaps = 18/153 (11%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPA-LEV 60
+P N+ EL +EVL+ +LP+ +S L LK L + + L L L++
Sbjct: 432 LPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKI 491
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG--------KLTKLQILSLR 112
L L + + + +P F+L L+ LYLS +LP + L L+ L L+
Sbjct: 492 LRLKFTEMGK--IPRWVFHLKNLKELYLSGC---VLPEQLSTMQLEGFQDLKNLRTLYLK 546
Query: 113 DNDLISLPKEIGEL---TQLKELHIQGNRLTVL 142
+ L +P+ + +L Q L +G++L VL
Sbjct: 547 -SSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL 578
Score = 33.9 bits (76), Expect = 0.12
Identities = 29/107 (27%), Positives = 43/107 (40%), Gaps = 27/107 (25%)
Query: 71 NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT------------------------KL 106
N LP N F LT + L L LP + +L L
Sbjct: 430 NGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENL 489
Query: 107 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTG 153
+IL L+ ++ +P+ + L LKEL++ G VLP +L + L G
Sbjct: 490 KILRLKFTEMGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEG 533
Score = 32.7 bits (73), Expect = 0.26
Identities = 22/74 (29%), Positives = 31/74 (41%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
M+P + + K L+ L N + L + L L HL L N L TLP +L+
Sbjct: 716 MLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775
Query: 61 LDLTYNNLSENSLP 74
L N+LP
Sbjct: 776 NCLIVEENLLNTLP 789
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 92.8 bits (229), Expect = 2e-19
Identities = 57/168 (33%), Positives = 88/168 (52%), Gaps = 4/168 (2%)
Query: 9 LKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNL 68
L+NL L ++N I +P QI +L L+ L+L N + LP L LDL+YN+L
Sbjct: 632 LQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHL 691
Query: 69 SENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQ 128
+ +P YL+ L+ +++N+ E+LP + + KLQ L L N L++L +GEL+
Sbjct: 692 T--FIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSN 749
Query: 129 LKELHIQGNRLTVLPPELGNLDLTGQKQVFKAEN--NPWVTPIADQFQ 174
L L + GN L LPPEL + + EN N P+ ++ Q
Sbjct: 750 LTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQ 797
Score = 60.1 bits (144), Expect = 2e-09
Identities = 45/135 (33%), Positives = 63/135 (46%), Gaps = 3/135 (2%)
Query: 29 ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYL 88
+ + LK L L L +P SL L LDL NNL +F +L L L L
Sbjct: 581 LKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKL 640
Query: 89 SDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 148
N+ +P IG L+ L+ LSL N++ +LP ++ T+L L + N LT +P E+
Sbjct: 641 WHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQY 700
Query: 149 LDLTGQKQVFKAENN 163
L Q F NN
Sbjct: 701 L---SNLQYFAVTNN 712
Score = 43.1 bits (100), Expect = 2e-04
Identities = 46/155 (29%), Positives = 75/155 (48%), Gaps = 8/155 (5%)
Query: 2 VPPNIAELKNLEVLNFFNNQI-EELPT-QISSLQKLKHLNLGM--NRLNTLPRGFGSL-P 56
+P + LKNL+ L + E+L T Q+ Q LK+L + L+ +P+ L P
Sbjct: 502 IPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLP 561
Query: 57 ALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDL 116
+L+ L L N S+ + N + L++L L D E +P I L L L LR+N+L
Sbjct: 562 SLQKLSLD-NEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNL 620
Query: 117 ISLPKEIG--ELTQLKELHIQGNRLTVLPPELGNL 149
++ + I L L L + N + +P ++G L
Sbjct: 621 KTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGAL 655
Score = 37.4 bits (85), Expect = 0.010
Identities = 19/55 (34%), Positives = 32/55 (58%)
Query: 96 LPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 150
LP ++ +LT++++LSL + LP + +L LKEL + + L V P L L+
Sbjct: 432 LPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLE 486
Score = 36.6 bits (83), Expect = 0.018
Identities = 42/153 (27%), Positives = 71/153 (46%), Gaps = 18/153 (11%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPA-LEV 60
+P N+ EL +EVL+ +LP+ +S L LK L + + L L L++
Sbjct: 432 LPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKI 491
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIG--------KLTKLQILSLR 112
L L + + + +P F+L L+ LYLS +LP + L L+ L L+
Sbjct: 492 LRLKFTEMGK--IPRWVFHLKNLKELYLSGC---VLPEQLSTMQLEGFQDLKNLRTLYLK 546
Query: 113 DNDLISLPKEIGEL---TQLKELHIQGNRLTVL 142
+ L +P+ + +L Q L +G++L VL
Sbjct: 547 -SSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVL 578
Score = 33.9 bits (76), Expect = 0.12
Identities = 29/107 (27%), Positives = 43/107 (40%), Gaps = 27/107 (25%)
Query: 71 NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLT------------------------KL 106
N LP N F LT + L L LP + +L L
Sbjct: 430 NGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENL 489
Query: 107 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTG 153
+IL L+ ++ +P+ + L LKEL++ G VLP +L + L G
Sbjct: 490 KILRLKFTEMGKIPRWVFHLKNLKELYLSG---CVLPEQLSTMQLEG 533
Score = 32.7 bits (73), Expect = 0.26
Identities = 22/74 (29%), Positives = 31/74 (41%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
M+P + + K L+ L N + L + L L HL L N L TLP +L+
Sbjct: 716 MLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775
Query: 61 LDLTYNNLSENSLP 74
L N+LP
Sbjct: 776 NCLIVEENLLNTLP 789
>gi|14249428 leucine-rich repeats and calponin homology (CH) domain
containing 3 [Homo sapiens]
Length = 712
Score = 92.0 bits (227), Expect = 4e-19
Identities = 65/189 (34%), Positives = 98/189 (51%), Gaps = 7/189 (3%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +LE LN + N I +P I +LQ L LN+ N+L+TLP +LP L+VL
Sbjct: 97 IPIEACHFVSLENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLP-LKVL 155
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+ N L SLP +L L L +S N+ + +P IG L L+ L++R N L+ LP+
Sbjct: 156 IASNNKLV--SLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPE 213
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVF 181
E+ EL ++ L N++T +P NL Q +NNP +P A G H+F
Sbjct: 214 ELAELPLIR-LDFSCNKITTIPVCYRNL---RHLQTITLDNNPLQSPPAQICIKGKVHIF 269
Query: 182 EYIRSETYK 190
+Y+ + K
Sbjct: 270 KYLNIQACK 278
Score = 55.5 bits (132), Expect = 4e-08
Identities = 46/142 (32%), Positives = 72/142 (50%), Gaps = 9/142 (6%)
Query: 12 LEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSEN 71
L+VL NN++ LP +I L+ L L++ N + T+P G+L AL L++ N+L
Sbjct: 152 LKVLIASNNKLVSLPEEIGHLRHLMELDVSCNEIQTIPSQIGNLEALRDLNVRRNHLVH- 210
Query: 72 SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEI---GELTQ 128
LP L +R L S N +P L LQ ++L +N L S P +I G++
Sbjct: 211 -LPEELAELPLIR-LDFSCNKITTIPVCYRNLRHLQTITLDNNPLQSPPAQICIKGKVHI 268
Query: 129 LKELHIQGNRLTVLPPELGNLD 150
K L+IQ ++ P+L + D
Sbjct: 269 FKYLNIQACKIA---PDLPDYD 287
Score = 36.2 bits (82), Expect = 0.023
Identities = 36/121 (29%), Positives = 50/121 (41%), Gaps = 4/121 (3%)
Query: 47 TLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKL 106
+L R VL L+ L E LT LS N +P + L
Sbjct: 48 SLDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSL 107
Query: 107 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWV 166
+ L+L N + +P+ I L L L+I N+L+ LP L NL L +V A NN V
Sbjct: 108 ENLNLYQNCIRYIPEAILNLQALTFLNISRNQLSTLPVHLCNLPL----KVLIASNNKLV 163
Query: 167 T 167
+
Sbjct: 164 S 164
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 91.7 bits (226), Expect = 5e-19
Identities = 71/204 (34%), Positives = 97/204 (47%), Gaps = 28/204 (13%)
Query: 3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLD 62
P + +L LE L+ +N++ LP IS+L+ LK L L L TLP GF L +LE L
Sbjct: 197 PRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLM 256
Query: 63 LTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS---- 118
L N L +LP F L L+ L LS N FE P + L L+ L L N L S
Sbjct: 257 LDNNGLQ--ALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSL 314
Query: 119 -------------------LPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFK 159
LP I ELT L+EL +QGN++ VLP G L G ++K
Sbjct: 315 ISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVG---LWK 371
Query: 160 AENNPWVTPIADQFQLGVSHVFEY 183
++NP + P + G+ ++ Y
Sbjct: 372 IKDNPLIQPPYEVCMKGIPYIAAY 395
Score = 79.0 bits (193), Expect = 3e-15
Identities = 50/144 (34%), Positives = 71/144 (49%), Gaps = 2/144 (1%)
Query: 6 IAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTY 65
++ L+ L LN +NQ+ LP Q+ +L L+ L++ NRL LP L L LD+ +
Sbjct: 131 VSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDH 190
Query: 66 NNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGE 125
N L+ + P L L L +S N LP DI L L+IL L +L +LP E
Sbjct: 191 NQLT--AFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCE 248
Query: 126 LTQLKELHIQGNRLTVLPPELGNL 149
L L+ L + N L LP + L
Sbjct: 249 LASLESLMLDNNGLQALPAQFSCL 272
Score = 77.4 bits (189), Expect = 9e-15
Identities = 52/161 (32%), Positives = 83/161 (51%), Gaps = 4/161 (2%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P + L +LE L+ N++ LP +S L +L+ L++ N+L PR L ALE L
Sbjct: 150 LPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEEL 209
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
D++ N L LP + L L+ L+LS + LP +L L+ L L +N L +LP
Sbjct: 210 DVSSNRL--RGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPA 267
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAEN 162
+ L +LK L++ N P L L L G ++++ + N
Sbjct: 268 QFSCLQRLKMLNLSSNLFEEFPAAL--LPLAGLEELYLSRN 306
Score = 52.8 bits (125), Expect = 2e-07
Identities = 45/141 (31%), Positives = 64/141 (45%), Gaps = 24/141 (17%)
Query: 30 SSLQKLKHLNLGMNRLNTLPRGFGS-LPALEVLDLTYN--------------NLSENSLP 74
++L ++ LNLG N L +P G GS L +L VL L N +L+E +
Sbjct: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
Query: 75 GN---------FFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGE 125
N L LR L LS N LP +G L L+ L + N L LP +
Sbjct: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSC 179
Query: 126 LTQLKELHIQGNRLTVLPPEL 146
L++L+ L + N+LT P +L
Sbjct: 180 LSRLRTLDVDHNQLTAFPRQL 200
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 91.7 bits (226), Expect = 5e-19
Identities = 55/139 (39%), Positives = 75/139 (53%), Gaps = 2/139 (1%)
Query: 10 KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLS 69
+ L L ++NQI +P + L+ L+ L L N+L TLP G L +LD+++N L
Sbjct: 630 RKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGL- 688
Query: 70 ENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQL 129
+SLP L L+ L LS N E LP ++ KL+ L L DN L L +G L L
Sbjct: 689 -HSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRAL 747
Query: 130 KELHIQGNRLTVLPPELGN 148
L ++GNRL LP ELGN
Sbjct: 748 SRLELKGNRLEALPEELGN 766
Score = 81.6 bits (200), Expect = 5e-16
Identities = 53/147 (36%), Positives = 80/147 (54%), Gaps = 4/147 (2%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
VP ++ +L++LE L N++E LP+Q+ L+ L++ N L++LP G L L+ L
Sbjct: 645 VPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHL 704
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L+YN L +LP F+ LR L L DN L P +G L L L L+ N L +LP+
Sbjct: 705 ALSYNALE--ALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPE 762
Query: 122 EIGELTQLKE--LHIQGNRLTVLPPEL 146
E+G LK+ L ++ LP E+
Sbjct: 763 ELGNCGGLKKAGLLVEDTLYQGLPAEV 789
Score = 56.2 bits (134), Expect = 2e-08
Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 2/150 (1%)
Query: 2 VPPNIAELK-NLEVLNFFNNQIEELP-TQISSLQKLKHLNLGMNRLNTLPRGFGSLPALE 59
VP ++ ++ +L+ L+ N+ + + L L+ L L L +P SL AL+
Sbjct: 549 VPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQ 608
Query: 60 VLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISL 119
LDL N+L +F + L L L N +P + KL L+ L L N L +L
Sbjct: 609 ELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETL 668
Query: 120 PKEIGELTQLKELHIQGNRLTVLPPELGNL 149
P ++G + L+ L + N L LPPE+G L
Sbjct: 669 PSQLGLCSGLRLLDVSHNGLHSLPPEVGLL 698
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 90.5 bits (223), Expect = 1e-18
Identities = 64/199 (32%), Positives = 98/199 (49%), Gaps = 22/199 (11%)
Query: 8 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 67
+L ++ + N+ E+P L L+ L+L N L L G+L AL L+L+ N
Sbjct: 66 DLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQ 125
Query: 68 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 127
LS L + LR L +S+N LPPDIG L L+ L + N+L SLP E+ L+
Sbjct: 126 LS---LLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLS 182
Query: 128 QLKELHIQGNRLTVLPPELGNLDLT-------------------GQKQVFKAENNPWVTP 168
L++L+++ N+L+ LP ELG+L L QV ++NP +P
Sbjct: 183 SLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSP 242
Query: 169 IADQFQLGVSHVFEYIRSE 187
A G H+F+Y+ +E
Sbjct: 243 PAQVCLKGKLHIFKYLSTE 261
Score = 61.2 bits (147), Expect = 7e-10
Identities = 37/125 (29%), Positives = 64/125 (51%), Gaps = 3/125 (2%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+PP+I L +L L+ +N+++ LP+++ L L+ LN+ N+L+TLP G LP + L
Sbjct: 151 LPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVR-L 209
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
D + N +S +P +F L L+ + L N + P + KL I +
Sbjct: 210 DFSCNRVSR--IPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGS 267
Query: 122 EIGEL 126
+G+L
Sbjct: 268 ALGDL 272
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 89.4 bits (220), Expect = 2e-18
Identities = 58/161 (36%), Positives = 81/161 (50%), Gaps = 21/161 (13%)
Query: 10 KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLS 69
+ LE L NQIEELP Q+ + Q L+ L++ N L+ LP SL L+ LD++ N +
Sbjct: 46 RTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQ 105
Query: 70 E---------------------NSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 108
E + LP F L L LYL+D E LP + G+L KL+I
Sbjct: 106 EFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRI 165
Query: 109 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
L LR+N L +LPK + +L QL+ L + N LP L +
Sbjct: 166 LELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQI 206
Score = 89.4 bits (220), Expect = 2e-18
Identities = 54/142 (38%), Positives = 80/142 (56%), Gaps = 2/142 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
V +I+ + LE L +N +++LP I L+KL L + N+L LP G+L LE
Sbjct: 245 VDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEF 304
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
D + N L SLP YL +LR L + +N LP +IG + ++SLR N L LP+
Sbjct: 305 DCSCNELE--SLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPE 362
Query: 122 EIGELTQLKELHIQGNRLTVLP 143
EIG++ +L+ L++ NRL LP
Sbjct: 363 EIGQMQKLRVLNLSDNRLKNLP 384
Score = 84.3 bits (207), Expect = 7e-17
Identities = 51/150 (34%), Positives = 78/150 (52%), Gaps = 2/150 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P IA L NL+ L+ N ++E P I + L + +N ++ LP GF L L +
Sbjct: 84 LPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQL--LNLT 141
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N+ LP NF L LR L L +N + LP + KL +L+ L L +N+ LP+
Sbjct: 142 QLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPE 201
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDL 151
+ ++ L+EL + N L VLP +G L +
Sbjct: 202 VLDQIQNLRELWMDNNALQVLPGSIGKLKM 231
Score = 79.3 bits (194), Expect = 2e-15
Identities = 51/149 (34%), Positives = 76/149 (51%), Gaps = 2/149 (1%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
++P +I +LK L L+ N+IE + IS + L+ L L N L LP G L L
Sbjct: 221 VLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTT 280
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
L + N L+ LP L+ L S N+ E LP IG L L+ L++ +N L LP
Sbjct: 281 LKVDDNQLT--MLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELP 338
Query: 121 KEIGELTQLKELHIQGNRLTVLPPELGNL 149
+EIG + + ++ N+L LP E+G +
Sbjct: 339 REIGSCKNVTVMSLRSNKLEFLPEEIGQM 367
Score = 78.6 bits (192), Expect = 4e-15
Identities = 51/147 (34%), Positives = 76/147 (51%), Gaps = 2/147 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P + +++NL L NN ++ LP I L+ L +L++ NR+ T+ ALE L
Sbjct: 199 LPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDL 258
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L+ N L + LP + L L L + DN +LP IG L+ L+ N+L SLP
Sbjct: 259 LLSSNMLQQ--LPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPS 316
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGN 148
IG L L+ L + N L LP E+G+
Sbjct: 317 TIGYLHSLRTLAVDENFLPELPREIGS 343
Score = 78.2 bits (191), Expect = 5e-15
Identities = 59/173 (34%), Positives = 78/173 (45%), Gaps = 25/173 (14%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +L NL L + +E LP L KL+ L L N L TLP+ L LE L
Sbjct: 130 LPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERL 189
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDN------- 114
DL N E LP + LR L++ +N ++LP IGKL L L + N
Sbjct: 190 DLGNNEFGE--LPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDM 247
Query: 115 ---------DLI-------SLPKEIGELTQLKELHIQGNRLTVLPPELGNLDL 151
DL+ LP IG L +L L + N+LT+LP +GNL L
Sbjct: 248 DISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSL 300
Score = 74.7 bits (182), Expect = 6e-14
Identities = 48/143 (33%), Positives = 71/143 (49%), Gaps = 2/143 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +I LK L L +NQ+ LP I +L L+ + N L +LP G L +L L
Sbjct: 268 LPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTL 327
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+ N L E LP + + L N E LP +IG++ KL++L+L DN L +LP
Sbjct: 328 AVDENFLPE--LPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPF 385
Query: 122 EIGELTQLKELHIQGNRLTVLPP 144
+L +L L + N+ L P
Sbjct: 386 SFTKLKELAALWLSDNQSKALIP 408
Score = 53.9 bits (128), Expect = 1e-07
Identities = 51/176 (28%), Positives = 79/176 (44%), Gaps = 10/176 (5%)
Query: 53 GSLPALEVLDLTYNNLSENSLPGNFF-YLTTLRALYLSDNDFEILPPDIGKLTKLQILSL 111
G + VLD Y++ S +P F + TL LYL N E LP + L+ LS+
Sbjct: 19 GEEEIISVLD--YSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSI 76
Query: 112 RDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIAD 171
DNDL +LP I L LKEL I N + P N+ + +A NP ++ + D
Sbjct: 77 PDNDLSNLPTTIASLVNLKELDISKNGVQEFPE---NIKCCKCLTIIEASVNP-ISKLPD 132
Query: 172 QFQLGVSHVFEYIRSETYKYL---YGRHMQANPEPPKKNNDKSKKISRKPLAAKNR 224
F ++ Y+ ++L +GR ++ ++N+ K+ S LA R
Sbjct: 133 GFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLER 188
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 87.8 bits (216), Expect = 7e-18
Identities = 53/147 (36%), Positives = 82/147 (55%), Gaps = 2/147 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I++L N+ L F+NN IE P+ + L L+ L+LG N+L +P SL L VL
Sbjct: 226 IPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVL 285
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+L YN L+ + P +L L +L L+ N LP +I +L L+ L + N L L
Sbjct: 286 NLEYNQLT--TFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAV 343
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGN 148
EI +L ++KEL + N+L V+ ++ N
Sbjct: 344 EIFQLLKIKELQLADNKLEVISHKIEN 370
Score = 77.8 bits (190), Expect = 7e-15
Identities = 45/148 (30%), Positives = 79/148 (53%), Gaps = 1/148 (0%)
Query: 3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLD 62
P + L+NL+VL+ NQ++++ + I +L+ ++ LN N+ P L +LE L+
Sbjct: 572 PRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLN 631
Query: 63 LTY-NNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
++ LPG +T L+ L +S+N +P +IG+L L L +N + LP
Sbjct: 632 ISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPP 691
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
+ L L++L++ GN LT LP + N+
Sbjct: 692 SLLSLNDLQQLNLSGNNLTALPSAIYNI 719
Score = 77.8 bits (190), Expect = 7e-15
Identities = 48/148 (32%), Positives = 76/148 (51%), Gaps = 5/148 (3%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGM---NRLNTLPRGFGSLPAL 58
+ +I LK ++ LNF +NQ P ++ LQ L+ LN+ +L LP ++ L
Sbjct: 594 ISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQL 653
Query: 59 EVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS 118
+ LD++ N + E +P N L L +L+ +N LPP + L LQ L+L N+L +
Sbjct: 654 KELDISNNAIRE--IPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTA 711
Query: 119 LPKEIGELTQLKELHIQGNRLTVLPPEL 146
LP I + LKE++ N L P E+
Sbjct: 712 LPSAIYNIFSLKEINFDDNPLLRPPVEI 739
Score = 76.3 bits (186), Expect = 2e-14
Identities = 54/148 (36%), Positives = 70/148 (47%), Gaps = 2/148 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I L NL +LN +N I +P +IS L ++ L N + P L LE+L
Sbjct: 203 LPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEIL 262
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N L +P L TLR L L N P + L KL L L N + SLPK
Sbjct: 263 SLGKNKLRH--IPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPK 320
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
EI EL L+ L + N+LT L E+ L
Sbjct: 321 EIRELKNLETLLMDHNKLTFLAVEIFQL 348
Score = 75.5 bits (184), Expect = 3e-14
Identities = 49/148 (33%), Positives = 77/148 (52%), Gaps = 5/148 (3%)
Query: 5 NIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLT 64
+ L NL+ L+ NQI+++P IS++ L L L N+ T PR +L L+VLDL+
Sbjct: 528 HFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLS 587
Query: 65 YNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQ---ILSLRDNDLISLPK 121
N L + + + L ++ L S N F P ++ +L L+ I ++ L LP
Sbjct: 588 ENQLQK--ISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPG 645
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNL 149
E+ +TQLKEL I N + +P +G L
Sbjct: 646 ELSNMTQLKELDISNNAIREIPRNIGEL 673
Score = 72.0 bits (175), Expect = 4e-13
Identities = 54/192 (28%), Positives = 82/192 (42%), Gaps = 44/192 (22%)
Query: 3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLD 62
P ++ L NLE+L+ N++ +P + SL+ L+ LNL N+L T P+ LP L LD
Sbjct: 250 PSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLD 309
Query: 63 LTYNNLSE---------------------NSLPGNFFYLTTLRALYLSDNDFEIL----- 96
LT N +S L F L ++ L L+DN E++
Sbjct: 310 LTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIE 369
Query: 97 ------------------PPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNR 138
P I L+ LSL DN L LPK I +L L++LH+ N
Sbjct: 370 NFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNN 429
Query: 139 LTVLPPELGNLD 150
+ + + +L+
Sbjct: 430 MVKITDCISHLN 441
Score = 72.0 bits (175), Expect = 4e-13
Identities = 48/155 (30%), Positives = 74/155 (47%), Gaps = 2/155 (1%)
Query: 3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLD 62
P + L +L L+ N I E+P IS ++L HL L N+L F SL L+ LD
Sbjct: 480 PLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLD 539
Query: 63 LTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKE 122
L N + + +P + + +L L L N FE P ++ L LQ+L L +N L + +
Sbjct: 540 LGKNQIKK--IPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSD 597
Query: 123 IGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQV 157
I L +++L+ N+ P EL L Q +
Sbjct: 598 ICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNI 632
Score = 70.5 bits (171), Expect = 1e-12
Identities = 45/142 (31%), Positives = 71/142 (50%), Gaps = 2/142 (1%)
Query: 8 ELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNN 67
+L LE+L+ N + LP++I L L+ LN+ N ++ +P+ L + L YNN
Sbjct: 186 DLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQL-FFYNN 244
Query: 68 LSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELT 127
EN P + L L L L N +P + L L++L+L N L + PK + L
Sbjct: 245 YIEN-FPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLP 303
Query: 128 QLKELHIQGNRLTVLPPELGNL 149
+L L + GN ++ LP E+ L
Sbjct: 304 KLISLDLTGNLISSLPKEIREL 325
Score = 70.5 bits (171), Expect = 1e-12
Identities = 48/151 (31%), Positives = 76/151 (50%), Gaps = 5/151 (3%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P +I+ K L L N++ SL LK+L+LG N++ +P ++ +L VL
Sbjct: 502 IPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVL 561
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N + P L L+ L LS+N + + DI L +Q L+ N I P
Sbjct: 562 ILCCNKF--ETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPI 619
Query: 122 EIGELTQLKELH---IQGNRLTVLPPELGNL 149
E+ +L L++L+ I+G +LT LP EL N+
Sbjct: 620 ELCQLQSLEQLNISQIKGRKLTRLPGELSNM 650
Score = 60.5 bits (145), Expect = 1e-09
Identities = 42/145 (28%), Positives = 67/145 (46%), Gaps = 2/145 (1%)
Query: 6 IAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTY 65
I+ L N+ L F N I ++P +I + QK+ + L N++ P G +L +L L +
Sbjct: 437 ISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNG 496
Query: 66 NNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGE 125
N +SE +P + + L L LS+N I L L+ L L N + +P I
Sbjct: 497 NYISE--IPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN 554
Query: 126 LTQLKELHIQGNRLTVLPPELGNLD 150
+ L L + N+ P EL L+
Sbjct: 555 MISLHVLILCCNKFETFPRELCTLE 579
Score = 50.1 bits (118), Expect = 2e-06
Identities = 39/161 (24%), Positives = 73/161 (45%), Gaps = 7/161 (4%)
Query: 1 MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEV 60
++ I + L +L N ++ +P +IS L+ L+L N+L LP+ L L
Sbjct: 363 VISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRK 422
Query: 61 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 120
L + NN+ + + +L + +L S N +P +I K+ + L N ++ P
Sbjct: 423 LHVNRNNMVK--ITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFP 480
Query: 121 KEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAE 161
+ L L L + GN ++ +P +D++ KQ+ E
Sbjct: 481 LGLCALDSLYYLSVNGNYISEIP-----VDISFSKQLLHLE 516
Score = 47.4 bits (111), Expect = 1e-05
Identities = 39/138 (28%), Positives = 66/138 (47%), Gaps = 19/138 (13%)
Query: 14 VLNFFNNQ-IEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENS 72
++NF +++ + E+ Q+S + K L LG + ++L L E
Sbjct: 113 LVNFLSHETVGEVSPQVSE-ENQKQLGLGADNFT--------------VNLEAKGLQE-- 155
Query: 73 LPGNFFYLTTLRALYLSDNDFEILP-PDIGKLTKLQILSLRDNDLISLPKEIGELTQLKE 131
P + + ++ LYL N + D G L L+ILSL++N L SLP EI L L+
Sbjct: 156 FPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRI 215
Query: 132 LHIQGNRLTVLPPELGNL 149
L++ N ++ +P E+ L
Sbjct: 216 LNVSHNHISHIPKEISQL 233
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 84.3 bits (207), Expect = 7e-17
Identities = 56/150 (37%), Positives = 80/150 (53%), Gaps = 2/150 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P ++ L +L L+ N +E LP + ++ L L L N L+ LP G+LPAL L
Sbjct: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+T+N L +LP L+TL+ L LS N + LPP+IG L L L+L N L SLP
Sbjct: 177 TVTHNRLQ--TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPA 234
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDL 151
+ L L+ L + N L +P +L L L
Sbjct: 235 SLAGLRSLRLLVLHSNLLASVPADLARLPL 264
Score = 81.6 bits (200), Expect = 5e-16
Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 2/145 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P + +++ L L +N + ELP + +L L L + NRL TLP G+L L+ L
Sbjct: 140 LPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRL 199
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
DL+ N L ++LP L +L L L+ N + LP + L L++L L N L S+P
Sbjct: 200 DLSQNLL--DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
Query: 122 EIGELTQLKELHIQGNRLTVLPPEL 146
++ L L L ++ N+L LPPEL
Sbjct: 258 DLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 78.6 bits (192), Expect = 4e-15
Identities = 53/128 (41%), Positives = 67/128 (52%), Gaps = 2/128 (1%)
Query: 22 IEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLT 81
+ LP +S L L HL+L N L TLP + L L L++N LSE LP L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSE--LPEALGALP 171
Query: 82 TLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTV 141
L L ++ N + LPP +G L+ LQ L L N L +LP EIG L L EL++ NRL
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 142 LPPELGNL 149
LP L L
Sbjct: 232 LPASLAGL 239
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 84.3 bits (207), Expect = 7e-17
Identities = 56/150 (37%), Positives = 80/150 (53%), Gaps = 2/150 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P ++ L +L L+ N +E LP + ++ L L L N L+ LP G+LPAL L
Sbjct: 117 LPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFL 176
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
+T+N L +LP L+TL+ L LS N + LPP+IG L L L+L N L SLP
Sbjct: 177 TVTHNRLQ--TLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPA 234
Query: 122 EIGELTQLKELHIQGNRLTVLPPELGNLDL 151
+ L L+ L + N L +P +L L L
Sbjct: 235 SLAGLRSLRLLVLHSNLLASVPADLARLPL 264
Score = 81.6 bits (200), Expect = 5e-16
Identities = 51/145 (35%), Positives = 78/145 (53%), Gaps = 2/145 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P + +++ L L +N + ELP + +L L L + NRL TLP G+L L+ L
Sbjct: 140 LPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRL 199
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
DL+ N L ++LP L +L L L+ N + LP + L L++L L N L S+P
Sbjct: 200 DLSQNLL--DTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
Query: 122 EIGELTQLKELHIQGNRLTVLPPEL 146
++ L L L ++ N+L LPPEL
Sbjct: 258 DLARLPLLTRLDLRDNQLRDLPPEL 282
Score = 78.6 bits (192), Expect = 4e-15
Identities = 53/128 (41%), Positives = 67/128 (52%), Gaps = 2/128 (1%)
Query: 22 IEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLT 81
+ LP +S L L HL+L N L TLP + L L L++N LSE LP L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSE--LPEALGALP 171
Query: 82 TLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTV 141
L L ++ N + LPP +G L+ LQ L L N L +LP EIG L L EL++ NRL
Sbjct: 172 ALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQS 231
Query: 142 LPPELGNL 149
LP L L
Sbjct: 232 LPASLAGL 239
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 83.2 bits (204), Expect = 2e-16
Identities = 50/132 (37%), Positives = 77/132 (58%), Gaps = 2/132 (1%)
Query: 10 KNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLS 69
++L+VLN N +E+P + L+ L+ L+LG N+L ++P +L +LE L L N +
Sbjct: 120 RSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIK 179
Query: 70 ENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQL 129
E +P L +L L L DN + +PP + +L L+ LSL +N L LP+EI L L
Sbjct: 180 E--IPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHL 237
Query: 130 KELHIQGNRLTV 141
+EL ++GN L V
Sbjct: 238 EELSLRGNPLVV 249
Score = 74.3 bits (181), Expect = 8e-14
Identities = 51/152 (33%), Positives = 75/152 (49%), Gaps = 8/152 (5%)
Query: 4 PNIAELKNLEVLNFFNNQI---EELPTQISS---LQKLKHLNLGMNRLNTLPRGFGSLPA 57
P + L+ L L NN++ LP ++ + L+ LNL N +P L A
Sbjct: 85 PELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRA 144
Query: 58 LEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLI 117
L+ L L N L S+P L +L LYL N + +PP++G L L L L DN +
Sbjct: 145 LQTLSLGGNQLQ--SIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQ 202
Query: 118 SLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
S+P ++ +L L+ L + N LT LP E+ NL
Sbjct: 203 SIPPQLSQLHSLRSLSLHNNLLTYLPREILNL 234
Score = 62.4 bits (150), Expect = 3e-10
Identities = 50/145 (34%), Positives = 71/145 (48%), Gaps = 28/145 (19%)
Query: 33 QKLKHLNLGMNRLNTLPRGFGS-LPALEVLDLTYNNLS---------------------- 69
+ L L L NRL +LPR GS P L++LD++ N L+
Sbjct: 44 EALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRL 103
Query: 70 --ENSLPGNFF---YLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIG 124
++LP +L+ L LS N F+ +P + +L LQ LSL N L S+P EI
Sbjct: 104 GGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIE 163
Query: 125 ELTQLKELHIQGNRLTVLPPELGNL 149
L L+ L++ GN + +PPELGNL
Sbjct: 164 NLQSLECLYLGGNFIKEIPPELGNL 188
Score = 28.9 bits (63), Expect = 3.7
Identities = 27/85 (31%), Positives = 35/85 (41%), Gaps = 4/85 (4%)
Query: 83 LRALYLSDNDFEILPPDIGK-LTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRL-- 139
L L L N LP +G LQ+L + N L +L E+ L L+ L + NRL
Sbjct: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGG 105
Query: 140 -TVLPPELGNLDLTGQKQVFKAENN 163
+ LP L L QV N
Sbjct: 106 PSALPKGLAQSPLCRSLQVLNLSGN 130
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 82.4 bits (202), Expect = 3e-16
Identities = 56/170 (32%), Positives = 86/170 (50%), Gaps = 7/170 (4%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
VP + L +L LN +NQI EL I ++ LNL N+L +LP L L+ L
Sbjct: 238 VPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKL 297
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N L + LP LT L ++N+ E++P + + KL+ L L N L++LP+
Sbjct: 298 YLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPE 357
Query: 122 EIGELTQLKELHIQGNRLTVLPP-------ELGNLDLTGQKQVFKAENNP 164
I LT+++ L ++ N V+PP E N+D + Q Q+ A +P
Sbjct: 358 AIHFLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRLAGASP 407
Score = 78.2 bits (191), Expect = 5e-15
Identities = 46/148 (31%), Positives = 76/148 (51%), Gaps = 1/148 (0%)
Query: 3 PPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLD 62
P N+ + +L L + LP ++++LQKL+HL++ N L TL SLP+L +
Sbjct: 26 PENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIV 85
Query: 63 LTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKE 122
N+L + +P + F L L L LS N P ++ + +L+L N + ++P +
Sbjct: 86 ARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQ 145
Query: 123 IG-ELTQLKELHIQGNRLTVLPPELGNL 149
+ LT L L + NRL LPP++ L
Sbjct: 146 LFINLTDLLYLDLSENRLESLPPQMRRL 173
Score = 60.8 bits (146), Expect = 9e-10
Identities = 47/151 (31%), Positives = 73/151 (48%), Gaps = 27/151 (17%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
VP +I +L +L VL+ +NQ+ E P ++ + + + LNL N ++T+P
Sbjct: 96 VPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIP------------ 143
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP- 120
N L F LT L L LS+N E LPP + +L LQ L L N L+
Sbjct: 144 ----NQL--------FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQL 191
Query: 121 KEIGELTQLKELHIQGNRLTV--LPPELGNL 149
+++ +T L+ LH++ + T LP L L
Sbjct: 192 RQLPAMTALQTLHLRSTQRTQSNLPTSLEGL 222
Score = 59.3 bits (142), Expect = 3e-09
Identities = 47/172 (27%), Positives = 79/172 (45%), Gaps = 25/172 (14%)
Query: 3 PPNIAELKNLEVLNFFNNQIEELPTQIS-SLQKLKHLNLGMNRLNTLP------------ 49
P + KN+ VLN +N I+ +P Q+ +L L +L+L NRL +LP
Sbjct: 120 PRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTL 179
Query: 50 ------------RGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILP 97
R ++ AL+ L L ++++LP + L+ L + LS ND +P
Sbjct: 180 VLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVP 239
Query: 98 PDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
+ L L+ L+L N + L I + ++ L++ N+LT LP + L
Sbjct: 240 ECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKL 291
Score = 46.6 bits (109), Expect = 2e-05
Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 2/100 (2%)
Query: 53 GSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLR 112
G LP + +DL+ N+ P N +T+LR L L+ LP ++ L KL+ LS+
Sbjct: 5 GVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVS 64
Query: 113 DNDLISLPKEIGELTQLKELHIQGNRL--TVLPPELGNLD 150
N+L +L E+ L L+ + + N L + +P ++ LD
Sbjct: 65 HNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLD 104
>gi|223005922 leucine rich repeat containing 10-like [Homo sapiens]
Length = 292
Score = 81.6 bits (200), Expect = 5e-16
Identities = 52/145 (35%), Positives = 74/145 (51%), Gaps = 2/145 (1%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P + L L+ L + ELP +I L++L+ L L N+L LP G LP L L
Sbjct: 36 LPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRL 95
Query: 62 DLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPK 121
L N L +LP +F L +LR L++ N P + +L LQ L + DN L +LP
Sbjct: 96 YLGGNRLL--ALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPA 153
Query: 122 EIGELTQLKELHIQGNRLTVLPPEL 146
E+ +T L+ L + GNR PP L
Sbjct: 154 ELPRMTGLRGLWLYGNRFEEFPPAL 178
Score = 64.3 bits (155), Expect = 8e-11
Identities = 55/188 (29%), Positives = 78/188 (41%), Gaps = 22/188 (11%)
Query: 2 VPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVL 61
+P I EL+ L +L N++E LP + L +L L LG NRL LP F L +L L
Sbjct: 59 LPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCL 118
Query: 62 DLTYNNLSE---------------------NSLPGNFFYLTTLRALYLSDNDFEILPPDI 100
+ N L +LP +T LR L+L N FE PP +
Sbjct: 119 WIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPAL 178
Query: 101 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKA 160
++ +L IL L N L P ++ L L+ N +T P + L G+ V +
Sbjct: 179 LRMGRLHILDLDRNRLGGFP-DLHPLRALRVFSYDHNPVTGPPRVADTVFLVGEGAVERM 237
Query: 161 ENNPWVTP 168
TP
Sbjct: 238 AERDEPTP 245
Score = 63.2 bits (152), Expect = 2e-10
Identities = 42/132 (31%), Positives = 59/132 (44%), Gaps = 2/132 (1%)
Query: 15 LNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLP 74
L ++ LP+ + +L +L+ L + L LP L L +L L +N L LP
Sbjct: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLER--LP 83
Query: 75 GNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHI 134
L L LYL N LP D +L L+ L + N L P+ + L L+ L +
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 135 QGNRLTVLPPEL 146
NRL LP EL
Sbjct: 144 GDNRLRALPAEL 155
Score = 49.3 bits (116), Expect = 3e-06
Identities = 29/77 (37%), Positives = 42/77 (54%)
Query: 73 LPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKEL 132
LP L+ L+ LY+S LP +I +L +L+IL+L N L LP + L +L L
Sbjct: 36 LPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDGLCRLPRLTRL 95
Query: 133 HIQGNRLTVLPPELGNL 149
++ GNRL LP + L
Sbjct: 96 YLGGNRLLALPADFAQL 112
Score = 35.4 bits (80), Expect = 0.040
Identities = 27/76 (35%), Positives = 37/76 (48%), Gaps = 6/76 (7%)
Query: 86 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP-- 143
L LS LP + L++LQ L + L LP+EI EL +L+ L + N+L LP
Sbjct: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
Query: 144 ----PELGNLDLTGQK 155
P L L L G +
Sbjct: 86 LCRLPRLTRLYLGGNR 101
Score = 27.7 bits (60), Expect = 8.3
Identities = 15/43 (34%), Positives = 23/43 (53%)
Query: 107 QILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNL 149
Q L L L LP + L++L++L++ G L LP E+ L
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEEL 66
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.137 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,829,116
Number of Sequences: 37866
Number of extensions: 373512
Number of successful extensions: 2648
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 139
Number of HSP's that attempted gapping in prelim test: 1163
Number of HSP's gapped (non-prelim): 840
length of query: 224
length of database: 18,247,518
effective HSP length: 98
effective length of query: 126
effective length of database: 14,536,650
effective search space: 1831617900
effective search space used: 1831617900
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.