Search of human proteins with 34577047

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34577047 dystonin isoform 1 [Homo sapiens]
         (5497 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34577047 dystonin isoform 1 [Homo sapiens]                        1.077e+04   0.0  
gi|221316624 dystonin isoform 4 [Homo sapiens]                       1.071e+04   0.0  
gi|221316622 dystonin isoform 3 [Homo sapiens]                       1.071e+04   0.0  
gi|221316618 dystonin isoform 2 [Homo sapiens]                       1.071e+04   0.0  
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]            9997   0.0  
gi|33188445 microfilament and actin filament cross-linker protei...  5881   0.0  
gi|33188443 microfilament and actin filament cross-linker protei...  4237   0.0  
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]            2291   0.0  
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]              2122   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       861   0.0  
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       861   0.0  
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        861   0.0  
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        861   0.0  
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        861   0.0  
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        861   0.0  
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        861   0.0  
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        861   0.0  
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   667   0.0  
gi|58530840 desmoplakin isoform I [Homo sapiens]                      609   e-173
gi|58530842 desmoplakin isoform II [Homo sapiens]                     577   e-164
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...   372   e-102
gi|5032281 dystrophin Dp427c isoform [Homo sapiens]                   325   1e-87
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]                  325   1e-87
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]                  325   1e-87
gi|5032285 dystrophin Dp427l isoform [Homo sapiens]                   325   1e-87
gi|5032283 dystrophin Dp427m isoform [Homo sapiens]                   325   1e-87
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...   318   9e-86
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]          312   5e-84
gi|45439327 periplakin [Homo sapiens]                                 311   9e-84
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...   311   1e-83

>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score = 1.077e+04 bits (27944), Expect = 0.0
 Identities = 5497/5497 (100%), Positives = 5497/5497 (100%)

Query: 1    MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLY 60
            MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLY
Sbjct: 1    MAGYLSPAAYLYVEEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLY 60

Query: 61   EDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITD 120
            EDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITD
Sbjct: 61   EDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITD 120

Query: 121  GNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCW 180
            GNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCW
Sbjct: 121  GNPKLTLGLIWTIILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCW 180

Query: 181  RDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDE 240
            RDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDE
Sbjct: 181  RDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDE 240

Query: 241  KSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFP 300
            KSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFP
Sbjct: 241  KSVITYVSSLYDAFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFP 300

Query: 301  NNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEK 360
            NNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEK
Sbjct: 301  NNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEK 360

Query: 361  EWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLES 420
            EWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLES
Sbjct: 361  EWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLES 420

Query: 421  GVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNEC 480
            GVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNEC
Sbjct: 421  GVQFQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNEC 480

Query: 481  SSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLS 540
            SSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLS
Sbjct: 481  SSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLS 540

Query: 541  SGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTE 600
            SGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTE
Sbjct: 541  SGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTE 600

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI
Sbjct: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
            SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE
Sbjct: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR
Sbjct: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
            AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI
Sbjct: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
            HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ
Sbjct: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
            IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ
Sbjct: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
            NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL
Sbjct: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
            EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE
Sbjct: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080

Query: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
            NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS
Sbjct: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
            SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA
Sbjct: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200

Query: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
            VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH
Sbjct: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
            KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ
Sbjct: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320

Query: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
            PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ
Sbjct: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380

Query: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
            KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK
Sbjct: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440

Query: 1441 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1500
            EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA
Sbjct: 1441 EHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLA 1500

Query: 1501 KHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYK 1560
            KHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYK
Sbjct: 1501 KHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYK 1560

Query: 1561 EKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKN 1620
            EKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKN
Sbjct: 1561 EKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKN 1620

Query: 1621 TENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKV 1680
            TENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKV
Sbjct: 1621 TENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKV 1680

Query: 1681 AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV 1740
            AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV
Sbjct: 1681 AAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEV 1740

Query: 1741 NGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLS 1800
            NGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLS
Sbjct: 1741 NGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLS 1800

Query: 1801 PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL 1860
            PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL
Sbjct: 1801 PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL 1860

Query: 1861 ENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1920
            ENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD
Sbjct: 1861 ENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1920

Query: 1921 TSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1980
            TSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT
Sbjct: 1921 TSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1980

Query: 1981 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2040
            ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND
Sbjct: 1981 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2040

Query: 2041 IQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV 2100
            IQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV
Sbjct: 2041 IQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV 2100

Query: 2101 PLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSAR 2160
            PLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSAR
Sbjct: 2101 PLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSAR 2160

Query: 2161 FSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYM 2220
            FSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYM
Sbjct: 2161 FSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYM 2220

Query: 2221 QESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 2280
            QESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA
Sbjct: 2221 QESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEA 2280

Query: 2281 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2340
            VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP
Sbjct: 2281 VTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTP 2340

Query: 2341 EIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKD 2400
            EIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKD
Sbjct: 2341 EIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKD 2400

Query: 2401 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT 2460
            MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT
Sbjct: 2401 MTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPT 2460

Query: 2461 DTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKW 2520
            DTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKW
Sbjct: 2461 DTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKW 2520

Query: 2521 QELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQ 2580
            QELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQ
Sbjct: 2521 QELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQ 2580

Query: 2581 QVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSD 2640
            QVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSD
Sbjct: 2581 QVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSD 2640

Query: 2641 RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2700
            RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI
Sbjct: 2641 RCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2700

Query: 2701 QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACA 2760
            QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACA
Sbjct: 2701 QQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACA 2760

Query: 2761 SSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT 2820
            SSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT
Sbjct: 2761 SSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT 2820

Query: 2821 IAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVET 2880
            IAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVET
Sbjct: 2821 IAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVET 2880

Query: 2881 LWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCE 2940
            LWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCE
Sbjct: 2881 LWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCE 2940

Query: 2941 IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD 3000
            IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD
Sbjct: 2941 IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD 3000

Query: 3001 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 3060
            IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE
Sbjct: 3001 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE 3060

Query: 3061 TIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAET 3120
            TIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAET
Sbjct: 3061 TIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAET 3120

Query: 3121 LQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLL 3180
            LQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLL
Sbjct: 3121 LQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLL 3180

Query: 3181 DRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV 3240
            DRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV
Sbjct: 3181 DRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV 3240

Query: 3241 FQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQ 3300
            FQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQ
Sbjct: 3241 FQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQ 3300

Query: 3301 LQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRK 3360
            LQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRK
Sbjct: 3301 LQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRK 3360

Query: 3361 STVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3420
            STVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF
Sbjct: 3361 STVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQF 3420

Query: 3421 HETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ 3480
            HETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ
Sbjct: 3421 HETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ 3480

Query: 3481 SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3540
            SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL
Sbjct: 3481 SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3540

Query: 3541 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3600
            NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV
Sbjct: 3541 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3600

Query: 3601 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3660
            LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE
Sbjct: 3601 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3660

Query: 3661 TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3720
            TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN
Sbjct: 3661 TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3720

Query: 3721 ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSA 3780
            ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSA
Sbjct: 3721 ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSA 3780

Query: 3781 QLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 3840
            QLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS
Sbjct: 3781 QLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 3840

Query: 3841 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 3900
            ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL
Sbjct: 3841 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 3900

Query: 3901 IAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQ 3960
            IAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQ
Sbjct: 3901 IAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQ 3960

Query: 3961 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 4020
            STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK
Sbjct: 3961 STQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLK 4020

Query: 4021 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 4080
            QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD
Sbjct: 4021 QRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD 4080

Query: 4081 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4140
            HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI
Sbjct: 4081 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4140

Query: 4141 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4200
            AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA
Sbjct: 4141 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4200

Query: 4201 GGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT 4260
            GGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT
Sbjct: 4201 GGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT 4260

Query: 4261 VQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPV 4320
            VQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPV
Sbjct: 4261 VQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPV 4320

Query: 4321 GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4380
            GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR
Sbjct: 4321 GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4380

Query: 4381 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL 4440
            WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL
Sbjct: 4381 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL 4440

Query: 4441 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNER 4500
            NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNER
Sbjct: 4441 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNER 4500

Query: 4501 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVN 4560
            KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVN
Sbjct: 4501 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVN 4560

Query: 4561 SHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4620
            SHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA
Sbjct: 4561 SHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRA 4620

Query: 4621 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4680
            KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR
Sbjct: 4621 KQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4680

Query: 4681 TGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQAL 4740
            TGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQAL
Sbjct: 4681 TGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQAL 4740

Query: 4741 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR 4800
            IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR
Sbjct: 4741 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR 4800

Query: 4801 DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR 4860
            DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR
Sbjct: 4801 DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR 4860

Query: 4861 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4920
            FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT
Sbjct: 4861 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4920

Query: 4921 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI 4980
            IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI
Sbjct: 4921 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI 4980

Query: 4981 EEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPA 5040
            EEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPA
Sbjct: 4981 EEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPA 5040

Query: 5041 SSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDI 5100
            SSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDI
Sbjct: 5041 SSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDI 5100

Query: 5101 WRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFD 5160
            WRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFD
Sbjct: 5101 WRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFD 5160

Query: 5161 RDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYR 5220
            RDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYR
Sbjct: 5161 RDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYR 5220

Query: 5221 FFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFIL 5280
            FFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFIL
Sbjct: 5221 FFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFIL 5280

Query: 5281 ADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRN 5340
            ADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRN
Sbjct: 5281 ADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRN 5340

Query: 5341 YGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITT 5400
            YGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITT
Sbjct: 5341 YGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITT 5400

Query: 5401 AAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQT 5460
            AAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQT
Sbjct: 5401 AAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQT 5460

Query: 5461 HRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR 5497
            HRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR
Sbjct: 5461 HRPTPRAGSRPSTAKPSKIPTPQRKSPASKLDKSSKR 5497


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score = 1.071e+04 bits (27794), Expect = 0.0
 Identities = 5470/5479 (99%), Positives = 5471/5479 (99%)

Query: 19   LQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG 78
            L   E  + R  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG
Sbjct: 48   LDPAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG 107

Query: 79   DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 138
            DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ
Sbjct: 108  DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 167

Query: 139  ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 198
            ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI
Sbjct: 168  ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 227

Query: 199  DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP 258
            DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP
Sbjct: 228  DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP 287

Query: 259  EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 318
            EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE
Sbjct: 288  EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 347

Query: 319  TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP 378
            TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP
Sbjct: 348  TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP 407

Query: 379  EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE 438
            EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE
Sbjct: 408  EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE 467

Query: 439  NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM 498
            NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM
Sbjct: 468  NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM 527

Query: 499  ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG 558
            ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG
Sbjct: 528  ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG 587

Query: 559  FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM 618
            FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM
Sbjct: 588  FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM 647

Query: 619  QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH 678
            QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH
Sbjct: 648  QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH 707

Query: 679  RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK 738
            RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK
Sbjct: 708  RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK 767

Query: 739  DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE 798
            DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE
Sbjct: 768  DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE 827

Query: 799  QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL 858
            QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL
Sbjct: 828  QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL 887

Query: 859  QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH 918
            QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH
Sbjct: 888  QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH 947

Query: 919  RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 978
            RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS
Sbjct: 948  RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 1007

Query: 979  WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1038
            WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE
Sbjct: 1008 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1067

Query: 1039 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1098
            KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD
Sbjct: 1068 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1127

Query: 1099 LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN 1158
            LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN
Sbjct: 1128 LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN 1187

Query: 1159 QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW 1218
            QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW
Sbjct: 1188 QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW 1247

Query: 1219 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 1278
            RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI
Sbjct: 1248 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 1307

Query: 1279 DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1338
            DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV
Sbjct: 1308 DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1367

Query: 1339 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1398
            SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ
Sbjct: 1368 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1427

Query: 1399 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
            EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK
Sbjct: 1428 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1487

Query: 1459 TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV 1518
            TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV
Sbjct: 1488 TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV 1547

Query: 1519 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1578
            KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI
Sbjct: 1548 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1607

Query: 1579 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1638
            GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA
Sbjct: 1608 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1667

Query: 1639 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1698
            LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD
Sbjct: 1668 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1727

Query: 1699 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE 1758
            WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE
Sbjct: 1728 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE 1787

Query: 1759 NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY 1818
            NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY
Sbjct: 1788 NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY 1847

Query: 1819 ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK 1878
            ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK
Sbjct: 1848 ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK 1907

Query: 1879 RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR 1938
            RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR
Sbjct: 1908 RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR 1967

Query: 1939 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR 1998
            FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR
Sbjct: 1968 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR 2027

Query: 1999 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2058
            QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS
Sbjct: 2028 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2087

Query: 2059 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE 2118
            VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE
Sbjct: 2088 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE 2147

Query: 2119 QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2178
            QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL
Sbjct: 2148 QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2207

Query: 2179 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2238
            KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH
Sbjct: 2208 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2267

Query: 2239 SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2298
            SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL
Sbjct: 2268 SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2327

Query: 2299 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2358
            KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA
Sbjct: 2328 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2387

Query: 2359 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2418
            VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK
Sbjct: 2388 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2447

Query: 2419 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2478
            IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE
Sbjct: 2448 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2507

Query: 2479 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2538
            LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS
Sbjct: 2508 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2567

Query: 2539 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2598
            NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ
Sbjct: 2568 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2627

Query: 2599 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL 2658
            LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL
Sbjct: 2628 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL 2687

Query: 2659 LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS 2718
            LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS
Sbjct: 2688 LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS 2747

Query: 2719 ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2778
            ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT
Sbjct: 2748 ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2807

Query: 2779 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2838
            KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA
Sbjct: 2808 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2867

Query: 2839 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2898
            LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC
Sbjct: 2868 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2927

Query: 2899 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2958
            LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD
Sbjct: 2928 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2987

Query: 2959 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3018
            MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML
Sbjct: 2988 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3047

Query: 3019 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS 3078
            QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS
Sbjct: 3048 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS 3107

Query: 3079 FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 3138
            FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL
Sbjct: 3108 FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 3167

Query: 3139 MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE 3198
            MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE
Sbjct: 3168 MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE 3227

Query: 3199 EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW 3258
            EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW
Sbjct: 3228 EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW 3287

Query: 3259 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3318
            LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL
Sbjct: 3288 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3347

Query: 3319 LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE 3378
            LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE
Sbjct: 3348 LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE 3407

Query: 3379 PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL 3438
            PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL
Sbjct: 3408 PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL 3467

Query: 3439 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3498
            VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL
Sbjct: 3468 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3527

Query: 3499 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3558
            DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE
Sbjct: 3528 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3587

Query: 3559 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT 3618
            GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT
Sbjct: 3588 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT 3647

Query: 3619 KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE 3678
            KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE
Sbjct: 3648 KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE 3707

Query: 3679 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3738
            LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID
Sbjct: 3708 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3767

Query: 3739 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3798
            AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI
Sbjct: 3768 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3827

Query: 3799 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3858
            IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE
Sbjct: 3828 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3887

Query: 3859 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3918
            TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL
Sbjct: 3888 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3947

Query: 3919 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3978
            LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI
Sbjct: 3948 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4007

Query: 3979 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4038
            VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS
Sbjct: 4008 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4067

Query: 4039 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4098
            AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL
Sbjct: 4068 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4127

Query: 4099 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4158
            EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL
Sbjct: 4128 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4187

Query: 4159 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4218
            NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK
Sbjct: 4188 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4247

Query: 4219 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER 4278
            QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER
Sbjct: 4248 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER 4307

Query: 4279 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4338
            IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ
Sbjct: 4308 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4367

Query: 4339 NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4398
            NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA
Sbjct: 4368 NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4427

Query: 4399 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4458
            LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK
Sbjct: 4428 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4487

Query: 4459 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4518
            SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL
Sbjct: 4488 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4547

Query: 4519 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4578
            QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY
Sbjct: 4548 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4607

Query: 4579 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4638
            FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE
Sbjct: 4608 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4667

Query: 4639 KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL 4698
            KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL
Sbjct: 4668 KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL 4727

Query: 4699 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH 4758
            DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH
Sbjct: 4728 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH 4787

Query: 4759 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4818
            GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE
Sbjct: 4788 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4847

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4878
            TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ
Sbjct: 4848 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4907

Query: 4879 HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ 4938
            HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ
Sbjct: 4908 HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ 4967

Query: 4939 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT 4998
            RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT
Sbjct: 4968 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT 5027

Query: 4999 RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR 5058
            RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR
Sbjct: 5028 RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR 5087

Query: 5059 VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD 5118
            VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD
Sbjct: 5088 VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD 5147

Query: 5119 FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP 5178
            FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP
Sbjct: 5148 FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP 5207

Query: 5179 NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI 5238
            NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI
Sbjct: 5208 NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI 5267

Query: 5239 LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS 5298
            LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS
Sbjct: 5268 LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS 5327

Query: 5299 RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA 5358
            RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA
Sbjct: 5328 RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA 5387

Query: 5359 ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR 5418
            ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR
Sbjct: 5388 ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR 5447

Query: 5419 PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK 5478
            PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK
Sbjct: 5448 PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK 5507

Query: 5479 IPTPQRKSPASKLDKSSKR 5497
            IPTPQRKSPASKLDKSSKR
Sbjct: 5508 IPTPQRKSPASKLDKSSKR 5526


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score = 1.071e+04 bits (27794), Expect = 0.0
 Identities = 5470/5479 (99%), Positives = 5471/5479 (99%)

Query: 19   LQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG 78
            L   E  + R  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG
Sbjct: 59   LDPAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG 118

Query: 79   DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 138
            DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ
Sbjct: 119  DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 178

Query: 139  ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 198
            ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI
Sbjct: 179  ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 238

Query: 199  DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP 258
            DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP
Sbjct: 239  DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP 298

Query: 259  EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 318
            EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE
Sbjct: 299  EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 358

Query: 319  TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP 378
            TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP
Sbjct: 359  TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP 418

Query: 379  EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE 438
            EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE
Sbjct: 419  EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE 478

Query: 439  NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM 498
            NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM
Sbjct: 479  NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM 538

Query: 499  ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG 558
            ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG
Sbjct: 539  ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG 598

Query: 559  FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM 618
            FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM
Sbjct: 599  FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM 658

Query: 619  QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH 678
            QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH
Sbjct: 659  QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH 718

Query: 679  RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK 738
            RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK
Sbjct: 719  RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK 778

Query: 739  DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE 798
            DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE
Sbjct: 779  DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE 838

Query: 799  QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL 858
            QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL
Sbjct: 839  QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL 898

Query: 859  QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH 918
            QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH
Sbjct: 899  QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH 958

Query: 919  RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 978
            RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS
Sbjct: 959  RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 1018

Query: 979  WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1038
            WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE
Sbjct: 1019 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1078

Query: 1039 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1098
            KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD
Sbjct: 1079 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1138

Query: 1099 LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN 1158
            LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN
Sbjct: 1139 LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN 1198

Query: 1159 QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW 1218
            QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW
Sbjct: 1199 QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW 1258

Query: 1219 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 1278
            RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI
Sbjct: 1259 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 1318

Query: 1279 DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1338
            DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV
Sbjct: 1319 DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1378

Query: 1339 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1398
            SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ
Sbjct: 1379 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1438

Query: 1399 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
            EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK
Sbjct: 1439 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1498

Query: 1459 TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV 1518
            TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV
Sbjct: 1499 TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV 1558

Query: 1519 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1578
            KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI
Sbjct: 1559 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1618

Query: 1579 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1638
            GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA
Sbjct: 1619 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1678

Query: 1639 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1698
            LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD
Sbjct: 1679 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1738

Query: 1699 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE 1758
            WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE
Sbjct: 1739 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE 1798

Query: 1759 NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY 1818
            NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY
Sbjct: 1799 NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY 1858

Query: 1819 ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK 1878
            ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK
Sbjct: 1859 ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK 1918

Query: 1879 RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR 1938
            RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR
Sbjct: 1919 RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR 1978

Query: 1939 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR 1998
            FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR
Sbjct: 1979 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR 2038

Query: 1999 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2058
            QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS
Sbjct: 2039 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2098

Query: 2059 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE 2118
            VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE
Sbjct: 2099 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE 2158

Query: 2119 QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2178
            QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL
Sbjct: 2159 QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2218

Query: 2179 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2238
            KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH
Sbjct: 2219 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2278

Query: 2239 SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2298
            SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL
Sbjct: 2279 SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2338

Query: 2299 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2358
            KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA
Sbjct: 2339 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2398

Query: 2359 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2418
            VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK
Sbjct: 2399 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2458

Query: 2419 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2478
            IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE
Sbjct: 2459 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2518

Query: 2479 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2538
            LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS
Sbjct: 2519 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2578

Query: 2539 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2598
            NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ
Sbjct: 2579 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2638

Query: 2599 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL 2658
            LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL
Sbjct: 2639 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL 2698

Query: 2659 LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS 2718
            LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS
Sbjct: 2699 LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS 2758

Query: 2719 ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2778
            ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT
Sbjct: 2759 ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2818

Query: 2779 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2838
            KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA
Sbjct: 2819 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2878

Query: 2839 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2898
            LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC
Sbjct: 2879 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2938

Query: 2899 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2958
            LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD
Sbjct: 2939 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2998

Query: 2959 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3018
            MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML
Sbjct: 2999 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3058

Query: 3019 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS 3078
            QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS
Sbjct: 3059 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS 3118

Query: 3079 FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 3138
            FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL
Sbjct: 3119 FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 3178

Query: 3139 MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE 3198
            MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE
Sbjct: 3179 MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE 3238

Query: 3199 EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW 3258
            EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW
Sbjct: 3239 EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW 3298

Query: 3259 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3318
            LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL
Sbjct: 3299 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3358

Query: 3319 LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE 3378
            LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE
Sbjct: 3359 LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE 3418

Query: 3379 PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL 3438
            PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL
Sbjct: 3419 PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL 3478

Query: 3439 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3498
            VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL
Sbjct: 3479 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3538

Query: 3499 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3558
            DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE
Sbjct: 3539 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3598

Query: 3559 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT 3618
            GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT
Sbjct: 3599 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT 3658

Query: 3619 KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE 3678
            KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE
Sbjct: 3659 KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE 3718

Query: 3679 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3738
            LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID
Sbjct: 3719 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3778

Query: 3739 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3798
            AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI
Sbjct: 3779 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3838

Query: 3799 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3858
            IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE
Sbjct: 3839 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3898

Query: 3859 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3918
            TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL
Sbjct: 3899 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3958

Query: 3919 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3978
            LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI
Sbjct: 3959 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4018

Query: 3979 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4038
            VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS
Sbjct: 4019 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4078

Query: 4039 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4098
            AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL
Sbjct: 4079 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4138

Query: 4099 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4158
            EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL
Sbjct: 4139 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4198

Query: 4159 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4218
            NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK
Sbjct: 4199 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4258

Query: 4219 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER 4278
            QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER
Sbjct: 4259 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER 4318

Query: 4279 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4338
            IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ
Sbjct: 4319 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4378

Query: 4339 NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4398
            NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA
Sbjct: 4379 NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4438

Query: 4399 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4458
            LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK
Sbjct: 4439 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4498

Query: 4459 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4518
            SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL
Sbjct: 4499 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4558

Query: 4519 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4578
            QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY
Sbjct: 4559 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4618

Query: 4579 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4638
            FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE
Sbjct: 4619 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4678

Query: 4639 KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL 4698
            KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL
Sbjct: 4679 KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL 4738

Query: 4699 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH 4758
            DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH
Sbjct: 4739 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH 4798

Query: 4759 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4818
            GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE
Sbjct: 4799 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4858

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4878
            TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ
Sbjct: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4918

Query: 4879 HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ 4938
            HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ
Sbjct: 4919 HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ 4978

Query: 4939 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT 4998
            RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT
Sbjct: 4979 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT 5038

Query: 4999 RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR 5058
            RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR
Sbjct: 5039 RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR 5098

Query: 5059 VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD 5118
            VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD
Sbjct: 5099 VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD 5158

Query: 5119 FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP 5178
            FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP
Sbjct: 5159 FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP 5218

Query: 5179 NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI 5238
            NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI
Sbjct: 5219 NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI 5278

Query: 5239 LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS 5298
            LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS
Sbjct: 5279 LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS 5338

Query: 5299 RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA 5358
            RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA
Sbjct: 5339 RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA 5398

Query: 5359 ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR 5418
            ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR
Sbjct: 5399 ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR 5458

Query: 5419 PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK 5478
            PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK
Sbjct: 5459 PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK 5518

Query: 5479 IPTPQRKSPASKLDKSSKR 5497
            IPTPQRKSPASKLDKSSKR
Sbjct: 5519 IPTPQRKSPASKLDKSSKR 5537


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score = 1.071e+04 bits (27794), Expect = 0.0
 Identities = 5470/5479 (99%), Positives = 5471/5479 (99%)

Query: 19   LQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG 78
            L   E  + R  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG
Sbjct: 197  LDPAERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG 256

Query: 79   DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 138
            DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ
Sbjct: 257  DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 316

Query: 139  ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 198
            ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI
Sbjct: 317  ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 376

Query: 199  DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP 258
            DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP
Sbjct: 377  DMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP 436

Query: 259  EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 318
            EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE
Sbjct: 437  EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 496

Query: 319  TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP 378
            TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP
Sbjct: 497  TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP 556

Query: 379  EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE 438
            EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE
Sbjct: 557  EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE 616

Query: 439  NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM 498
            NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM
Sbjct: 617  NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLM 676

Query: 499  ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG 558
            ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG
Sbjct: 677  ISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPG 736

Query: 559  FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM 618
            FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM
Sbjct: 737  FPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEM 796

Query: 619  QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH 678
            QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH
Sbjct: 797  QVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLH 856

Query: 679  RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK 738
            RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK
Sbjct: 857  RLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKK 916

Query: 739  DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE 798
            DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE
Sbjct: 917  DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVE 976

Query: 799  QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL 858
            QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL
Sbjct: 977  QHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELL 1036

Query: 859  QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH 918
            QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH
Sbjct: 1037 QYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSH 1096

Query: 919  RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 978
            RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS
Sbjct: 1097 RAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVS 1156

Query: 979  WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1038
            WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE
Sbjct: 1157 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLE 1216

Query: 1039 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1098
            KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD
Sbjct: 1217 KEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD 1276

Query: 1099 LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN 1158
            LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN
Sbjct: 1277 LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN 1336

Query: 1159 QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW 1218
            QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW
Sbjct: 1337 QVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQW 1396

Query: 1219 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 1278
            RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI
Sbjct: 1397 RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQI 1456

Query: 1279 DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1338
            DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV
Sbjct: 1457 DNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1516

Query: 1339 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1398
            SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ
Sbjct: 1517 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1576

Query: 1399 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
            EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK
Sbjct: 1577 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1636

Query: 1459 TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV 1518
            TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV
Sbjct: 1637 TLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQV 1696

Query: 1519 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1578
            KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI
Sbjct: 1697 KTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLI 1756

Query: 1579 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1638
            GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA
Sbjct: 1757 GHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKA 1816

Query: 1639 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1698
            LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD
Sbjct: 1817 LIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLD 1876

Query: 1699 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE 1758
            WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE
Sbjct: 1877 WLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQE 1936

Query: 1759 NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY 1818
            NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY
Sbjct: 1937 NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHY 1996

Query: 1819 ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK 1878
            ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK
Sbjct: 1997 ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLK 2056

Query: 1879 RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR 1938
            RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR
Sbjct: 2057 RQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDR 2116

Query: 1939 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR 1998
            FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR
Sbjct: 2117 FRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQR 2176

Query: 1999 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2058
            QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS
Sbjct: 2177 QLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS 2236

Query: 2059 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE 2118
            VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE
Sbjct: 2237 VNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLE 2296

Query: 2119 QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2178
            QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL
Sbjct: 2297 QDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL 2356

Query: 2179 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2238
            KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH
Sbjct: 2357 KTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLH 2416

Query: 2239 SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2298
            SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL
Sbjct: 2417 SLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSL 2476

Query: 2299 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2358
            KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA
Sbjct: 2477 KSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISA 2536

Query: 2359 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2418
            VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK
Sbjct: 2537 VTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDK 2596

Query: 2419 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2478
            IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE
Sbjct: 2597 IAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAE 2656

Query: 2479 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2538
            LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS
Sbjct: 2657 LKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESS 2716

Query: 2539 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2598
            NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ
Sbjct: 2717 NNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2776

Query: 2599 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL 2658
            LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL
Sbjct: 2777 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSL 2836

Query: 2659 LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS 2718
            LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS
Sbjct: 2837 LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLS 2896

Query: 2719 ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2778
            ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT
Sbjct: 2897 ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT 2956

Query: 2779 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 2838
            KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA
Sbjct: 2957 KKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAA 3016

Query: 2839 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 2898
            LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC
Sbjct: 3017 LQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC 3076

Query: 2899 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 2958
            LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD
Sbjct: 3077 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVD 3136

Query: 2959 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3018
            MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML
Sbjct: 3137 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTML 3196

Query: 3019 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS 3078
            QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS
Sbjct: 3197 QTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCS 3256

Query: 3079 FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 3138
            FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL
Sbjct: 3257 FLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEAL 3316

Query: 3139 MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE 3198
            MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE
Sbjct: 3317 MASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLE 3376

Query: 3199 EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW 3258
            EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW
Sbjct: 3377 EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNW 3436

Query: 3259 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3318
            LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL
Sbjct: 3437 LGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESL 3496

Query: 3319 LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE 3378
            LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE
Sbjct: 3497 LSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE 3556

Query: 3379 PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL 3438
            PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL
Sbjct: 3557 PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRL 3616

Query: 3439 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3498
            VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL
Sbjct: 3617 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3676

Query: 3499 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3558
            DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE
Sbjct: 3677 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3736

Query: 3559 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT 3618
            GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT
Sbjct: 3737 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDIT 3796

Query: 3619 KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE 3678
            KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE
Sbjct: 3797 KLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKE 3856

Query: 3679 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3738
            LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID
Sbjct: 3857 LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3916

Query: 3739 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3798
            AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI
Sbjct: 3917 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3976

Query: 3799 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3858
            IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE
Sbjct: 3977 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 4036

Query: 3859 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3918
            TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL
Sbjct: 4037 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 4096

Query: 3919 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3978
            LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI
Sbjct: 4097 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 4156

Query: 3979 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4038
            VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS
Sbjct: 4157 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4216

Query: 4039 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4098
            AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL
Sbjct: 4217 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDL 4276

Query: 4099 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4158
            EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL
Sbjct: 4277 EDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4336

Query: 4159 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4218
            NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK
Sbjct: 4337 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVK 4396

Query: 4219 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER 4278
            QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER
Sbjct: 4397 QQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEER 4456

Query: 4279 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4338
            IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ
Sbjct: 4457 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQ 4516

Query: 4339 NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4398
            NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA
Sbjct: 4517 NDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4576

Query: 4399 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4458
            LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK
Sbjct: 4577 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4636

Query: 4459 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4518
            SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL
Sbjct: 4637 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4696

Query: 4519 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4578
            QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY
Sbjct: 4697 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4756

Query: 4579 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4638
            FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE
Sbjct: 4757 FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE 4816

Query: 4639 KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL 4698
            KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL
Sbjct: 4817 KSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL 4876

Query: 4699 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH 4758
            DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH
Sbjct: 4877 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH 4936

Query: 4759 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4818
            GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE
Sbjct: 4937 GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWE 4996

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 4878
            TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ
Sbjct: 4997 TVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQ 5056

Query: 4879 HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ 4938
            HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ
Sbjct: 5057 HKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ 5116

Query: 4939 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT 4998
            RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT
Sbjct: 5117 RLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMT 5176

Query: 4999 RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR 5058
            RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR
Sbjct: 5177 RKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPR 5236

Query: 5059 VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD 5118
            VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD
Sbjct: 5237 VNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMD 5296

Query: 5119 FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP 5178
            FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP
Sbjct: 5297 FFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHP 5356

Query: 5179 NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI 5238
            NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI
Sbjct: 5357 NKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRI 5416

Query: 5239 LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS 5298
            LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS
Sbjct: 5417 LRSTVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRS 5476

Query: 5299 RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA 5358
            RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA
Sbjct: 5477 RPSSRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAA 5536

Query: 5359 ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR 5418
            ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR
Sbjct: 5537 ECSDFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSR 5596

Query: 5419 PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK 5478
            PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK
Sbjct: 5597 PGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSK 5656

Query: 5479 IPTPQRKSPASKLDKSSKR 5497
            IPTPQRKSPASKLDKSSKR
Sbjct: 5657 IPTPQRKSPASKLDKSSKR 5675


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score = 9997 bits (25942), Expect = 0.0
 Identities = 5116/5116 (100%), Positives = 5116/5116 (100%)

Query: 382  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 441
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115

Query: 442  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 501
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175

Query: 502  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 561
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235

Query: 562  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 621
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295

Query: 622  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 681
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355

Query: 682  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 741
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415

Query: 742  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 801
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475

Query: 802  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 861
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535

Query: 862  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 921
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595

Query: 922  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 981
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655

Query: 982  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1041
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715

Query: 1042 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1101
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775

Query: 1102 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1161
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835

Query: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1221
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895

Query: 1222 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1281
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955

Query: 1282 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1341
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015

Query: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075

Query: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1461
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK
Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135

Query: 1462 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1521
            DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL
Sbjct: 1136 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1195

Query: 1522 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1581
            QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ
Sbjct: 1196 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1255

Query: 1582 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1641
            EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE
Sbjct: 1256 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1315

Query: 1642 QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1701
            QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS
Sbjct: 1316 QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1375

Query: 1702 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1761
            NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN
Sbjct: 1376 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLN 1435

Query: 1762 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1821
            QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA
Sbjct: 1436 QQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETA 1495

Query: 1822 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 1881
            LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK
Sbjct: 1496 LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQK 1555

Query: 1882 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRS 1941
            SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRS
Sbjct: 1556 SFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRS 1615

Query: 1942 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLE 2001
            LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLE
Sbjct: 1616 LYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLE 1675

Query: 2002 ETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNE 2061
            ETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNE
Sbjct: 1676 ETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNE 1735

Query: 2062 RNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 2121
            RNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI
Sbjct: 1736 RNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI 1795

Query: 2122 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 2181
            AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK
Sbjct: 1796 AGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTK 1855

Query: 2182 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 2241
            VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL
Sbjct: 1856 VELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL 1915

Query: 2242 KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSW 2301
            KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSW
Sbjct: 1916 KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSW 1975

Query: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT 2361
            IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT
Sbjct: 1976 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTT 2035

Query: 2362 PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAE 2421
            PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAE
Sbjct: 2036 PAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAE 2095

Query: 2422 LNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2481
            LNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ
Sbjct: 2096 LNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2155

Query: 2482 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2541
            NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL
Sbjct: 2156 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2215

Query: 2542 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2601
            TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA
Sbjct: 2216 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2275

Query: 2602 AGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRS 2661
            AGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRS
Sbjct: 2276 AGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRS 2335

Query: 2662 LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALV 2721
            LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALV
Sbjct: 2336 LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALV 2395

Query: 2722 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE 2781
            KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE
Sbjct: 2396 KEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE 2455

Query: 2782 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 2841
            EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL
Sbjct: 2456 EQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQL 2515

Query: 2842 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP 2901
            QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP
Sbjct: 2516 QLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDP 2575

Query: 2902 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 2961
            AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT
Sbjct: 2576 AEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVT 2635

Query: 2962 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 3021
            EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ
Sbjct: 2636 EQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ 2695

Query: 3022 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 3081
            QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE
Sbjct: 2696 QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLE 2755

Query: 3082 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3141
            TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS
Sbjct: 2756 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 2815

Query: 3142 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFY 3201
            NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFY
Sbjct: 2816 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFY 2875

Query: 3202 SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ 3261
            SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ
Sbjct: 2876 SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQ 2935

Query: 3262 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3321
            GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW
Sbjct: 2936 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 2995

Query: 3322 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
            MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD
Sbjct: 2996 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3055

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
            KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC
Sbjct: 3056 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3115

Query: 3442 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3501
            EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS
Sbjct: 3116 EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3175

Query: 3502 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3561
            QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW
Sbjct: 3176 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3235

Query: 3562 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3621
            KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS
Sbjct: 3236 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3295

Query: 3622 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3681
            TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK
Sbjct: 3296 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3355

Query: 3682 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3741
            EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI
Sbjct: 3356 EAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3415

Query: 3742 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3801
            LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD
Sbjct: 3416 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3475

Query: 3802 LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3861
            LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE
Sbjct: 3476 LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3535

Query: 3862 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3921
            ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL
Sbjct: 3536 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3595

Query: 3922 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981
            SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER
Sbjct: 3596 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3655

Query: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041
            LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA
Sbjct: 3656 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 3715

Query: 4042 VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP 4101
            VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP
Sbjct: 3716 VQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDP 3775

Query: 4102 GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA 4161
            GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA
Sbjct: 3776 GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA 3835

Query: 4162 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4221
            WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI
Sbjct: 3836 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 3895

Query: 4222 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4281
            EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN
Sbjct: 3896 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 3955

Query: 4282 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341
            RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV
Sbjct: 3956 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4015

Query: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4401
            LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ
Sbjct: 4016 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4075

Query: 4402 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4461
            AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM
Sbjct: 4076 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4135

Query: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4521
            QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF
Sbjct: 4136 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4195

Query: 4522 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4581
            INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ
Sbjct: 4196 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4255

Query: 4582 KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSL 4641
            KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSL
Sbjct: 4256 KQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSL 4315

Query: 4642 DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDM 4701
            DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDM
Sbjct: 4316 DSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDM 4375

Query: 4702 LSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI 4761
            LSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI
Sbjct: 4376 LSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI 4435

Query: 4762 DLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVC 4821
            DLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVC
Sbjct: 4436 DLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVC 4495

Query: 4822 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKE 4881
            ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKE
Sbjct: 4496 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKE 4555

Query: 4882 FMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLA 4941
            FMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLA
Sbjct: 4556 FMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLA 4615

Query: 4942 SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 5001
            SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ
Sbjct: 4616 SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQ 4675

Query: 5002 PDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL 5061
            PDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL
Sbjct: 4676 PDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVNL 4735

Query: 5062 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 5121
            LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR
Sbjct: 4736 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 4795

Query: 5122 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 5181
            RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD
Sbjct: 4796 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 4855

Query: 5182 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 5241
            AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS
Sbjct: 4856 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 4915

Query: 5242 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 5301
            TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS
Sbjct: 4916 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 4975

Query: 5302 SRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECS 5361
            SRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECS
Sbjct: 4976 SRGASPNRSTSVSSQAAQAASPQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAECS 5035

Query: 5362 DFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGS 5421
            DFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGS
Sbjct: 5036 DFPVPSAEGTPIQGSKLRLPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGS 5095

Query: 5422 RAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPT 5481
            RAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPT
Sbjct: 5096 RAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPT 5155

Query: 5482 PQRKSPASKLDKSSKR 5497
            PQRKSPASKLDKSSKR
Sbjct: 5156 PQRKSPASKLDKSSKR 5171


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score = 5881 bits (15258), Expect = 0.0
 Identities = 3004/5500 (54%), Positives = 4025/5500 (73%), Gaps = 167/5500 (3%)

Query: 15   EQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLE 74
            +   L   E  + R  DERD+VQKKTFTKW+N+HLMKVRKH+NDLYEDLRDGHNLISLLE
Sbjct: 58   QDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLE 117

Query: 75   VLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTII 134
            VLSG  LPREKGRMRFHRLQNVQIALD+LK+RQVKLVNIRNDDITDGNPKLTLGLIWTII
Sbjct: 118  VLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTII 177

Query: 135  LHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYR 194
            LHFQISDI+++GES DMSAKE+LLLWTQ+ T GY GI+C NF++CW DGK+FNA+IH+YR
Sbjct: 178  LHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYR 237

Query: 195  PDLIDMNTVAVQSNLANLEHAFYVAEKIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAF 254
            PDL+DM  V +QSN  NLE AF VAE++GV RLLD EDVDV SPDEKSVITYVSS+YDAF
Sbjct: 238  PDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAF 297

Query: 255  PKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYL 314
            PKVPEGGEGI A +V+ +W EYQ+ V+ LI WI+ H   MS++TFP NPVELKALYNQY+
Sbjct: 298  PKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYI 357

Query: 315  QFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREK 374
             FKETEI  KE EK +I+ LYKLLE+WIEFGRIKL QGYHPND+E+EWGKLII MLEREK
Sbjct: 358  HFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREK 417

Query: 375  ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYI 434
            +LRP VERLE+L QIAN++Q  ++ CE+KL LA N LQ+D+  LESG   Q E+++  YI
Sbjct: 418  SLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYI 477

Query: 435  LECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQ 494
             ECE L+RQ  +D+QIL D  YYQ ++L  RV +L+DE++ LR EC              
Sbjct: 478  QECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLEC-------------- 523

Query: 495  TKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPA 554
            T L   G   SL     + + PS  +      T  L +  +T    S  TS         
Sbjct: 524  TNLYRKGHFTSL-----ELVPPSTLT------TTHLKAEPLTKATHSSSTS--------- 563

Query: 555  YTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNW 614
                                          RKP+ ++ L+  + +E+E N++FV +LL+W
Sbjct: 564  ----------------------------WFRKPMTRAELVAISSSEDEGNLRFVYELLSW 595

Query: 615  VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA 674
            V+EMQ++L+R EWG+DLPSVE  LE  +++H ++EE  SS+KEA++ E +M+     +YA
Sbjct: 596  VEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYA 655

Query: 675  EKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNI 734
            E L +LE+QY KL  TS  + RHL +LH FVSRAT ELIWLNEKEEEE+AYDWS+ N+NI
Sbjct: 656  ETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNI 715

Query: 735  ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLC 794
            + K++Y +EL  EL++K++  +S+Q+ AE L LENHPA+ T+EAY AA+Q+Q  W+ QLC
Sbjct: 716  SAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLC 775

Query: 795  QCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEK 854
             CVEQH+KENTAYF+FF+DA+E   +LRNL+D+I+RKYSCD ++S+ +LEDL+Q+SM+EK
Sbjct: 776  LCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEK 835

Query: 855  EELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLA 914
            E+L+Q KS++A+L+G++KTI+QLKPR+ D  LK +I +KA+CDYRQIEITI K+DECVL 
Sbjct: 836  EQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLE 895

Query: 915  NNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMK 974
            +NS R KWKVISPTGNEAMVPSVCF +PPPNK+A+++A+R+EQ YQ V+ LWH+ H+N K
Sbjct: 896  DNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTK 955

Query: 975  SVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDI 1034
            S++SW+YL  ++D ++  N+  +++  PGE  Q++ NLQ+ +EDFL+DS++S +FS +D 
Sbjct: 956  SLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADR 1015

Query: 1035 TQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT-- 1092
             +LE+EV  CK  +Q L+KS E E++EE+V  +YISE++NIRLRLE  E R++++I++  
Sbjct: 1016 LRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLA 1075

Query: 1093 --PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSEL 1150
                +RD   ++  RI EQE  +++L++L+ DL  ++ KC+ F  Q+ +SSSVPTLRSEL
Sbjct: 1076 SSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSEL 1135

Query: 1151 NVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIEN 1210
            N++++ M+ VY +S+ Y++KLKTV++++++ Q AE LVK YE KL +EE V+AD + +E 
Sbjct: 1136 NLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEA 1195

Query: 1211 LISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVER 1270
              STL+ W S+V +K  VF  L++E+ KAK ++++M +   ER+LD + ++EK  QL ER
Sbjct: 1196 HWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQER 1255

Query: 1271 WQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ 1330
            W  V  Q++ R  +LE I + L  YR  +  L  WI++    Q  ++  Q E+S+ L+ Q
Sbjct: 1256 WHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQ 1315

Query: 1331 LNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ 1390
            L+QQ  L +EIE  Q+K+D+CQK+++QYS  VKDYELQ MTY+A V+SQQKSP KRRRM 
Sbjct: 1316 LSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRML 1375

Query: 1391 SSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQ 1450
            SS+D I QEFMDLRTRYTALVTL TQ++K+  D+L+RLEEEEK +EEEK+EHVEK KEL 
Sbjct: 1376 SSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELL 1435

Query: 1451 KWVSNISKTLK------------DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLF 1498
             WVS +++  +            D EKA      +Q++ SEE++TKKEQ+SEA++T Q+F
Sbjct: 1436 GWVSTLARNTQGKATSSETKESTDIEKA----ILEQQVLSEELTTKKEQVSEAIKTSQIF 1491

Query: 1499 LAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQE 1558
            LAKHG K++++E+ ++ +Q+  L ++Y+ L   S  QLQ+ Q+    + E+K + ++Q  
Sbjct: 1492 LAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNT 1551

Query: 1559 YKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVV 1618
              ++L+ +C  + Q E  L GHQ      D +  L+K QS  ++LQ D+Q  A + A VV
Sbjct: 1552 CHQQLEDLCSWVGQAERALAGHQGRTTQQDLSA-LQKNQSDLKDLQDDIQNRATSFATVV 1610

Query: 1619 KNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETE 1678
            K+ E F++EN  KLS  +   + +KL++AK + E L  +   ++KEL++ VT+A+++ETE
Sbjct: 1611 KDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETE 1670

Query: 1679 KVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEED 1738
            K  A K+L E+K KI+ LLDW+++V     +  T    + + +G   ++G          
Sbjct: 1671 KSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG---------- 1720

Query: 1739 EVNGNLLETDVDGQVGTTQ--ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQG 1796
                  L+T  DG +G  Q  E L++Q + +KA+H++++SQ Q  I+ATQSAQ  L++ G
Sbjct: 1721 -----ALDT-TDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 1774

Query: 1797 QYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQS 1856
              L+PEE++ LQ+ + ELK  Y T+LA+SE ++K   +LQ+EL+KF  D+ EFE WL++S
Sbjct: 1775 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERS 1834

Query: 1857 EQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDG 1916
            E+ELEN+  G      L + LKRQ SFSEDVISHKGDLR++TISG +VL+   S  +   
Sbjct: 1835 EKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE--- 1891

Query: 1917 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQA 1976
            GK + S     V+ KL  AT+R+ +L+SKC  LG++L  L+ +Y  +++++  L A +QA
Sbjct: 1892 GK-EPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950

Query: 1977 CEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP 2036
            CEA   K LS+ +A DP  LQ QL  TK LQ +++  QV VEKL+K A  +++  G   P
Sbjct: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010

Query: 2037 AKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKE 2096
                +Q+T D I+  ++ LS S+ ER+  LQ  + +S SVQ+ L+ +L  +G VE +L+ 
Sbjct: 2011 DHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG 2070

Query: 2097 QGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKD 2156
            +    L+S  +Q+ ++ N+ L+QDIA ++SS+ A  E V +FMET D +TA+ LQ K+ +
Sbjct: 2071 KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAE 2130

Query: 2157 LSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2216
            +S RF +   + +E  + +++L  + E+FE+LS KLQ F+E K++ L   + P +D+T  
Sbjct: 2131 VSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF 2190

Query: 2217 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2276
             Q +QE   E  + +++L+ L  L+ E+SS G   D     ++  NL K F E++ T+KE
Sbjct: 2191 FQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE 2250

Query: 2277 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2336
            +++  +SCQEQLD F+ LV++ + W+KET   +P  + S  A++L K +E  K L + W+
Sbjct: 2251 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2310

Query: 2337 LKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTS 2396
             K   ++++N  G SL NLI  +T P    +  K+G  + +   +  +   +   K LT 
Sbjct: 2311 SKGTLVEEINCKGTSLENLIMEITAPD---SQGKTGSILPSVGSSVGSVNGYHTCKDLTE 2367

Query: 2397 IKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQT 2456
            I+ DM+D++  YE LG +L ++   L   L+++++  +E+++++QWL+   +        
Sbjct: 2368 IQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAM 2427

Query: 2457 PAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI 2516
             +PT TE VK Q E NK+F AEL+QN  K+Q++K+ L  LL   P++ EA  WK++  E+
Sbjct: 2428 SSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL 2487

Query: 2517 DSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN 2576
            +S+W+   ++T+ RQ++LEES+++L  FQ  E+QL+ WL+EKELM+ VLGPLSIDPNMLN
Sbjct: 2488 NSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLN 2547

Query: 2577 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTG 2636
             Q+QQVQ +L+EF  R+ Q+EQL  A QGIL+ PG+       V+++L ++ QKW  LT 
Sbjct: 2548 AQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTD 2607

Query: 2637 QLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM 2696
            +L+ R   IDQAIVKSTQYQ LL+ LS+K+  +  +LS   A+ST P+A+ QQLE   ++
Sbjct: 2608 KLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEI 2667

Query: 2697 KQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQ 2756
            + +++Q   ++K AQ LC++LS L+ E+YLK EL ++LE +    + +E  A + +  LQ
Sbjct: 2668 RSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQ 2727

Query: 2757 SACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2816
            +A AS+ QFQQM  + + WLD K+ +Q K+ PISAKL+ L+S ++++++F K+L   S  
Sbjct: 2728 AALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGS 2787

Query: 2817 YEKTIAEGENLLLKTQ-GSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYK 2875
            YE  +AEGE+LLL    G EK  LQ QL  +K +W+  +K+  +R+++LK+ ++KA KY+
Sbjct: 2788 YEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQ 2847

Query: 2876 EQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSL 2935
              VE L PWI+ C+  + E++  LDP + E+S+ + K++  E+++   ++E+LN+ A+ L
Sbjct: 2848 WHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL 2907

Query: 2936 LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA 2995
            ++  E D++ + DE   + Q +D VTE+L +K   LE MTQ+ +EFQE  K  +++++ A
Sbjct: 2908 INSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGA 2967

Query: 2996 KEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDV 3055
            K QL+I D+LGSQA SNK L  L+ QQ+ LQAL+ QVD  +   Q LV +A D    S +
Sbjct: 2968 KHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQL 3027

Query: 3056 LLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVG 3115
            L Q E   QE   + Q+V+  C  +E KL+GIG F   +REMFSQ A+ DDELD M  +G
Sbjct: 3028 LHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIG 3087

Query: 3116 RDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQ 3175
            RD ++LQ Q E ++ FL K+  L    + +   C+ ML  EE + DL+G+KR+LEAL+KQ
Sbjct: 3088 RDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE-EEGTLDLLGLKRELEALNKQ 3146

Query: 3176 CNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQL 3235
            C KL +R +AR+EQ+E T+ R+E+FY KLK  +     AEE E  Q  VG E E INQQL
Sbjct: 3147 CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQL 3206

Query: 3236 NMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA 3295
              FK+FQKE+++PLQ K Q VN LGQGLIQSA K    QGLEHD++++NARW TLNKKVA
Sbjct: 3207 ADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVA 3266

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            QR AQLQEALLHCG+FQDALE LLSW+ DTEEL+ANQKPPSAE+KVVKAQIQEQKLLQRL
Sbjct: 3267 QRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRL 3326

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV 3415
            LDDRK+TV++++ EG +IA +AE AD+ KI  QL  L+SRW  LL+KA  R +QLE I V
Sbjct: 3327 LDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILV 3386

Query: 3416 VAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQA 3475
            +A+QFHET EP++++L+  EK+L N EP+GTQ +K+++QI +HKALE+DI NH   +HQA
Sbjct: 3387 LAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQA 3446

Query: 3476 VSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVE 3535
            V IGQSL  L+S  ++ ++  K+D  Q  Y EIQ++   ++ LL QAL NA++FGEDEVE
Sbjct: 3447 VKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 3506

Query: 3536 LMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595
            ++NWL EV DKLS + V+D+  + L +Q ++   L E+I+ RK+NVDQA+ NG  LLKQT
Sbjct: 3507 VLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQT 3566

Query: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655
            TG+EVL+IQ+KL+ IK RY DIT  S+   +TLEQA QLA +  ST+EEL  WL +VE E
Sbjct: 3567 TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEE 3626

Query: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715
            L +   Q   GE+  Q Q R KELKKE   ++ +LD++NEVS ALLELVPWRAREGL+K+
Sbjct: 3627 LATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKL 3686

Query: 3716 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775
            V++ NE+Y+LVSDTI Q+V+EIDAAI RSQQ++QAADAEL+W+ ET++KLM+LG IRLEQ
Sbjct: 3687 VSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ 3746

Query: 3776 DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTI 3835
            DQT+AQLQVQK F+++I+RHKD +D+L     +I   C EE+K  +++K + +++ Y+ I
Sbjct: 3747 DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 3806

Query: 3836 CQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHR 3895
              +NSERY +LERAQ LVNQFWETYEEL PW+ ET+++I+QLP+PA+++E LRQQQEE R
Sbjct: 3807 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMR 3866

Query: 3896 QLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALD 3955
            QLRE IAEHKPHIDK+ K GPQL EL+P EG  ++EKY  A+ +Y+QIKE+V++RA+ALD
Sbjct: 3867 QLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALD 3926

Query: 3956 EAISQSTQ---FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKL 4012
            EA+SQSTQ   FHDKI+ +LE+LE +  RLR PP I AEV+KI+E IS+NK+ +V++EKL
Sbjct: 3927 EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKL 3986

Query: 4013 QPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVME 4072
            QP +E LK+RGEE+I RS G DKD++AK +QDKLDQMVF WE+I    EERE K LDV+E
Sbjct: 3987 QPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLE 4046

Query: 4073 LAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIV 4132
            LAEKFW D  +L+ TIKDTQD + DLE PGIDPS++KQQ EAAETI+EE DGL EEL+ +
Sbjct: 4047 LAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFI 4106

Query: 4133 INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQA 4192
              LG++LI ACGE +KP V+KSIDE+N+AW++LNK WK+R++KLE+AMQAAVQYQD LQA
Sbjct: 4107 RILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQA 4166

Query: 4193 VFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4252
            +FDW+D    KL +M P+GTDL TVK Q+ E+K+FK E YQQQIEME+LNHQ EL+LKK 
Sbjct: 4167 MFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKA 4226

Query: 4253 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4312
            T+E+D+  +++PL ELK +W++L E+I +RQHKLEGALLALGQFQHAL+EL++WLTHTE 
Sbjct: 4227 TDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEE 4286

Query: 4313 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4372
            LL  Q+P+ GDPK IE+ELAKHHVL+NDVLAHQ+TVE VNKAGN+L+ESSAG++AS+L++
Sbjct: 4287 LLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRS 4346

Query: 4373 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4432
            +LE +NQ W++VL+KTE+R+QQL   L+QA+GFH EIED    LT  E  L ASKP GGL
Sbjct: 4347 RLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGL 4406

Query: 4433 PETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM-LARCPKSAETNIDQDINNLKEKWE 4491
            PETA+EQL+ HME+ +  +AKEETY  L+ KG+ M L+R    + +  +Q +  L++KW 
Sbjct: 4407 PETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWH 4466

Query: 4492 SVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDE 4551
             V +K+ ERK+KLEEALNLA EF NSLQ+FINWLT AEQ+LN+AS PSLIL+TVL QI+E
Sbjct: 4467 VVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEE 4526

Query: 4552 HKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR 4611
            HKVFANEVN+HR+QIIELD+TG  LK+ SQKQDVVLIKNLL+SVQSRWEKVVQR +ERGR
Sbjct: 4527 HKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGR 4586

Query: 4612 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAK 4671
            SLDDARKRAKQFHEAW KL++WLE++E  LDSELEI+NDPDKIK QL++HKEFQK+LG K
Sbjct: 4587 SLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGK 4646

Query: 4672 HSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSG 4731
              VYDTT RTGR+LKEKT L +D+ KLD+ L E+RDKWDT+CGKSVERQ+KLEEALLFSG
Sbjct: 4647 QPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSG 4706

Query: 4732 QFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4791
            QF DALQAL+DWLY+VEPQLAEDQPVHGD+DLVMNL+D HK FQKELGKRT +VQ LKRS
Sbjct: 4707 QFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRS 4766

Query: 4792 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4851
             RELIE SRDD++WVK Q+QELSTRW+TVC LS+SKQ+RLE AL+QAE F   VH LLEW
Sbjct: 4767 GRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEW 4826

Query: 4852 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS 4911
            L+EAEQTLRF G LPDD +AL++LID HKEFMKK+EEKR ++N A  MG+ +LA+CHPD 
Sbjct: 4827 LSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDC 4886

Query: 4912 ITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDK 4971
            ITTIKHWITIIRARFEEVL WAKQHQQRL +AL+ L+A  ELLE LLAW+QWAETTL  +
Sbjct: 4887 ITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQR 4946

Query: 4972 DKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKG 5031
            D+E IPQ I+ VKALIAEHQTFMEEMTRKQPDVD+VTKTYKR+  +P    +H P ++K 
Sbjct: 4947 DQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEP----THAPFIEKS 5002

Query: 5032 RA-GRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEEL 5090
            R+ GRK     +  P    +Q E KNPR+N L ++WQQVWLLALER+RKLNDALDRLEEL
Sbjct: 5003 RSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEEL 5062

Query: 5091 REFANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRL 5150
            +EFANFDFD+WRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGIL+SKFPT++L
Sbjct: 5063 KEFANFDFDVWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGILASKFPTTKL 5122

Query: 5151 EMSAVADIFDRDGDGYIDYYEFVAALHPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQ 5210
            EM+AVADIFDRDGDGYIDYYEFVAALHPNKDAY+P TDADKIEDEVTRQVA+CKCAKRFQ
Sbjct: 5123 EMTAVADIFDRDGDGYIDYYEFVAALHPNKDAYRPTTDADKIEDEVTRQVAQCKCAKRFQ 5182

Query: 5211 VEQIGDNKYRFFLGNQFGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRAKGRT 5270
            VEQIG+NKYR      FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRA+GRT
Sbjct: 5183 VEQIGENKYR------FGDSQQLRLVRILRSTVMVRVGGGWMALDEFLVKNDPCRARGRT 5236

Query: 5271 NMELREKFILADGASQGMAAFRPRGRRSRPSSRGASPNRSTSVSSQAAQAAS--PQVPAT 5328
            N+ELREKFIL +GASQGM  FR RGRRS+PSSR ASP RS+S +SQ+  + +  P  PAT
Sbjct: 5237 NIELREKFILPEGASQGMTPFRSRGRRSKPSSRAASPTRSSSSASQSNHSCTSMPSSPAT 5296

Query: 5329 TTPKILHPLTRNYGKPWLTNSKMSTPCKAAECSDFPVPSAEGTPIQGSKLR--LPGYLSG 5386
                                               P    +  P  GSKL+   P + S 
Sbjct: 5297 -----------------------------------PASGTKVIPSSGSKLKRPTPTFHSS 5321

Query: 5387 KGFHSGEDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFDISE 5446
            +   +G+ S   + A+   +T  AD KK+ SRPGSRAGS+AGSRASSRRGSDASDFD+ E
Sbjct: 5322 RTSLAGDTSNSSSPASTGAKTNRADPKKSASRPGSRAGSRAGSRASSRRGSDASDFDLLE 5381

Query: 5447 IQSVCSDVETVPQTHRPTPRAGSRPSTAKPSKIPTPQRKS 5486
             QS CSD     ++     +  SR    KPSKIPT  +K+
Sbjct: 5382 TQSACSDTS---ESSAAGGQGNSRRGLNKPSKIPTMSKKT 5418


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score = 4237 bits (10988), Expect = 0.0
 Identities = 2190/4089 (53%), Positives = 2948/4089 (72%), Gaps = 96/4089 (2%)

Query: 1427 RLEEEEKSLEEEK----KEHVE---KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSE 1479
            RL   + ++E EK     +H +   + ++L+ WV N +  L       +       +  +
Sbjct: 1905 RLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQ 1964

Query: 1480 E-------ISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1532
            +       ++ +K QL      IQ F+++H   ++ ++  ++ + +  LQ S+  +  ++
Sbjct: 1965 QYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQT 2024

Query: 1533 LKQLQESQTSGDVKVEEKIVAERQQEYK---EKLQGICDLLTQTENRLIGHQEAFMIGDG 1589
              Q+   Q       +E +V   Q++     ++L+ +C  + Q E  L GHQ      D 
Sbjct: 2025 AAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL 2084

Query: 1590 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1649
            +  L+K QS  ++LQ D+Q  A + A VVK+ E F++EN  KLS  +   + +KL++AK 
Sbjct: 2085 SA-LQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKE 2143

Query: 1650 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1709
            + E L  +   ++KEL++ VT+A+++ETEK  A K+L E+K KI+ LLDW+++V     +
Sbjct: 2144 QYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQ 2203

Query: 1710 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKV 1767
              T    + + +G   ++G                L+T  DG +G  Q  E L++Q + +
Sbjct: 2204 LLTNLPGMEQLSGASLEKG---------------ALDT-TDGYMGVNQAPEKLDKQCEMM 2247

Query: 1768 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1827
            KA+H++++SQ Q  I+ATQSAQ  L++ G  L+PEE++ LQ+ + ELK  Y T+LA+SE 
Sbjct: 2248 KARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEA 2307

Query: 1828 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1887
            ++K   +LQ+EL+KF  D+ EFE WL++SE+ELEN+  G      L + LKRQ SFSEDV
Sbjct: 2308 ELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDV 2367

Query: 1888 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCN 1947
            ISHKGDLR++TISG +VL+   S  +   GK + S     V+ KL  AT+R+ +L+SKC 
Sbjct: 2368 ISHKGDLRFVTISGQKVLDMENSFKE---GK-EPSEIGNLVKDKLKDATERYTALHSKCT 2423

Query: 1948 VLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQ 2007
             LG++L  L+ +Y  +++++  L A +QACEA   K LS+ +A DP  LQ QL  TK LQ
Sbjct: 2424 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 2483

Query: 2008 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2067
             +++  QV VEKL+K A  +++  G   P    +Q+T D I+  ++ LS S+ ER+  LQ
Sbjct: 2484 EELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQ 2543

Query: 2068 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2127
              + +S SVQ+ L+ +L  +G VE +L+ +    L+S  +Q+ ++ N+ L+QDIA ++SS
Sbjct: 2544 KAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSS 2603

Query: 2128 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2187
            + A  E V +FMET D +TA+ LQ K+ ++S RF +   + +E  + +++L  + E+FE+
Sbjct: 2604 LEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH 2663

Query: 2188 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH 2247
            LS KLQ F+E K++ L   + P +D+T   Q +QE   E  + +++L+ L  L+ E+SS 
Sbjct: 2664 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSC 2723

Query: 2248 GLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTK 2307
            G   D     ++  NL K F E++ T+KE+++  +SCQEQLD F+ LV++ + W+KET  
Sbjct: 2724 GFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEG 2783

Query: 2308 KVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA 2367
             +P  + S  A++L K +E  K L + W+ K   ++++N  G SL NLI  +T P    +
Sbjct: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPD---S 2840

Query: 2368 AVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLS 2427
              K+G  + +   +  +   +   K LT I+ DM+D++  YE LG +L ++   L   L+
Sbjct: 2841 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN 2900

Query: 2428 KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQ 2487
            ++++  +E+++++QWL+   +         +PT TE VK Q E NK+F AEL+QN  K+Q
Sbjct: 2901 RMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQ 2960

Query: 2488 ELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2547
            ++K+ L  LL   P++ EA  WK++  E++S+W+   ++T+ RQ++LEES+++L  FQ  
Sbjct: 2961 KVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAA 3020

Query: 2548 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2607
            E+QL+ WL+EKELM+ VLGPLSIDPNMLN Q+QQVQ +L+EF  R+ Q+EQL  A QGIL
Sbjct: 3021 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGIL 3080

Query: 2608 SRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLS 2667
            + PG+       V+++L ++ QKW  LT +L+ R   IDQAIVKSTQYQ LL+ LS+K+ 
Sbjct: 3081 TGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVR 3140

Query: 2668 DLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLK 2727
             +  +LS   A+ST P+A+ QQLE   +++ +++Q   ++K AQ LC++LS L+ E+YLK
Sbjct: 3141 AVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLK 3200

Query: 2728 AELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH 2787
             EL ++LE +    + +E  A + +  LQ+A AS+ QFQQM  + + WLD K+ +Q K+ 
Sbjct: 3201 DELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260

Query: 2788 PISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQ-GSEKAALQLQLNTI 2846
            PISAKL+ L+S ++++++F K+L   S  YE  +AEGE+LLL    G EK  LQ QL  +
Sbjct: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVEL 3320

Query: 2847 KTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGEN 2906
            K +W+  +K+  +R+++LK+ ++KA KY+  VE L PWI+ C+  + E++  LDP + E+
Sbjct: 3321 KNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLES 3380

Query: 2907 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 2966
            S+ + K++  E+++   ++E+LN+ A+ L++  E D++ + DE   + Q +D VTE+L +
Sbjct: 3381 SLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQA 3440

Query: 2967 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3026
            K   LE MTQ+ +EFQE  K  +++++ AK QL+I D+LGSQA SNK L  L+ QQ+ LQ
Sbjct: 3441 KTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQ 3500

Query: 3027 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 3086
            AL+ QVD  +   Q LV +A D    S +L Q E   QE   + Q+V+  C  +E KL+G
Sbjct: 3501 ALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG 3560

Query: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNAN 3146
            IG F   +REMFSQ A+ DDELD M  +GRD ++LQ Q E ++ FL K+  L    + + 
Sbjct: 3561 IGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASE 3620

Query: 3147 KTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKE 3206
              C+ ML  EE + DL+G+KR+LEAL+KQC KL +R +AR+EQ+E T+ R+E+FY KLK 
Sbjct: 3621 AECRHMLE-EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG 3679

Query: 3207 FSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQS 3266
             +     AEE E  Q  VG E E INQQL  FK+FQKE+++PLQ K Q VN LGQGLIQS
Sbjct: 3680 LNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQS 3739

Query: 3267 AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE 3326
            A K    QGLEHD++++NARW TLNKKVAQR AQLQEALLHCG+FQDALE LLSW+ DTE
Sbjct: 3740 AGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTE 3799

Query: 3327 ELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL 3386
            EL+ANQKPPSAE+KVVKAQIQEQKLLQRLLDDRK+TV++++ EG +IA +AE AD+ KI 
Sbjct: 3800 ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKIT 3859

Query: 3387 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGT 3446
             QL  L+SRW  LL+KA  R +QLE I V+A+QFHET EP++++L+  EK+L N EP+GT
Sbjct: 3860 GQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGT 3919

Query: 3447 QASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI 3506
            Q +K+++QI +HKALE+DI NH   +HQAV IGQSL  L+S  ++ ++  K+D  Q  Y 
Sbjct: 3920 QTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYS 3979

Query: 3507 EIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE 3566
            EIQ++   ++ LL QAL NA++FGEDEVE++NWL EV DKLS + V+D+  + L +Q ++
Sbjct: 3980 EIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039

Query: 3567 LRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
               L E+I+ RK+NVDQA+ NG  LLKQTTG+EVL+IQ+KL+ IK RY DIT  S+   +
Sbjct: 4040 HLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALR 4099

Query: 3627 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3686
            TLEQA QLA +  ST+EEL  WL +VE EL +   Q   GE+  Q Q R KELKKE   +
Sbjct: 4100 TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEH 4159

Query: 3687 KALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ 3746
            + +LD++NEVS ALLELVPWRAREGL+K+V++ NE+Y+LVSDTI Q+V+EIDAAI RSQQ
Sbjct: 4160 RLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219

Query: 3747 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806
            ++QAADAEL+W+ ET++KLM+LG IRLEQDQT+AQLQVQK F+++I+RHKD +D+L    
Sbjct: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279

Query: 3807 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866
             +I   C EE+K  +++K + +++ Y+ I  +NSERY +LERAQ LVNQFWETYEEL PW
Sbjct: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339

Query: 3867 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3926
            + ET+++I+QLP+PA+++E LRQQQEE RQLRE IAEHKPHIDK+ K GPQL EL+P EG
Sbjct: 4340 IEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEG 4399

Query: 3927 FSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ---FHDKIDQILESLERIVERLR 3983
              ++EKY  A+ +Y+QIKE+V++RA+ALDEA+SQSTQ   FHDKI+ +LE+LE +  RLR
Sbjct: 4400 EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLR 4459

Query: 3984 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
             PP I AEV+KI+E IS+NK+ +V++EKLQP +E LK+RGEE+I RS G DKD++AK +Q
Sbjct: 4460 MPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ 4519

Query: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4103
            DKLDQMVF WE+I    EERE K LDV+ELAEKFW D  +L+ TIKDTQD + DLE PGI
Sbjct: 4520 DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGI 4579

Query: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4163
            DPS++KQQ EAAETI+EE DGL EEL+ +  LG++LI ACGE +KP V+KSIDE+N+AW+
Sbjct: 4580 DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWE 4639

Query: 4164 SLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4223
            +LNK WK+R++KLE+AMQAAVQYQD LQA+FDW+D    KL +M P+GTDL TVK Q+ E
Sbjct: 4640 NLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNE 4699

Query: 4224 LKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQ 4283
            +K+FK E YQQQIEME+LNHQ EL+LKK T+E+D+  +++PL ELK +W++L E+I +RQ
Sbjct: 4700 MKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759

Query: 4284 HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLA 4343
            HKLEGALLALGQFQHAL+EL++WLTHTE LL  Q+P+ GDPK IE+ELAKHHVL+NDVLA
Sbjct: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLA 4819

Query: 4344 HQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4403
            HQ+TVE VNKAGN+L+ESSAG++AS+L+++LE +NQ W++VL+KTE+R+QQL   L+QA+
Sbjct: 4820 HQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQ 4879

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK 4463
            GFH EIED    LT  E  L ASKP GGLPETA+EQL+ HME+ +  +AKEETY  L+ K
Sbjct: 4880 GFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDK 4939

Query: 4464 GQQM-LARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
            G+ M L+R    + +  +Q +  L++KW  V +K+ ERK+KLEEALNLA EF NSLQ+FI
Sbjct: 4940 GRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFI 4999

Query: 4523 NWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQK 4582
            NWLT AEQ+LN+AS PSLIL+TVL QI+EHKVFANEVN+HR+QIIELD+TG  LK+ SQK
Sbjct: 5000 NWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQK 5059

Query: 4583 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4642
            QDVVLIKNLL+SVQSRWEKVVQR +ERGRSLDDARKRAKQFHEAW KL++WLE++E  LD
Sbjct: 5060 QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLD 5119

Query: 4643 SELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDML 4702
            SELEI+NDPDKIK QL++HKEFQK+LG K  VYDTT RTGR+LKEKT L +D+ KLD+ L
Sbjct: 5120 SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFL 5179

Query: 4703 SELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID 4762
             E+RDKWDT+CGKSVERQ+KLEEALLFSGQF DALQAL+DWLY+VEPQLAEDQPVHGD+D
Sbjct: 5180 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD 5239

Query: 4763 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 4822
            LVMNL+D HK FQKELGKRT +VQ LKRS RELIE SRDD++WVK Q+QELSTRW+TVC 
Sbjct: 5240 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK 5299

Query: 4823 LSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF 4882
            LS+SKQ+RLE AL+QAE F   VH LLEWL+EAEQTLRF G LPDD +AL++LID HKEF
Sbjct: 5300 LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEF 5359

Query: 4883 MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS 4942
            MKK+EEKR ++N A  MG+ +LA+CHPD ITTIKHWITIIRARFEEVL WAKQHQQRL +
Sbjct: 5360 MKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 5419

Query: 4943 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQP 5002
            AL+ L+A  ELLE LLAW+QWAETTL  +D+E IPQ I+ VKALIAEHQTFMEEMTRKQP
Sbjct: 5420 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 5479

Query: 5003 DVDKVTKTYKRRAADPSSLQSHIPVLDKGRA-GRKRFPASSLYPSGSQTQIETKNPRVNL 5061
            DVD+VTKTYKR+  +P    +H P ++K R+ GRK     +  P    +Q E KNPR+N 
Sbjct: 5480 DVDRVTKTYKRKNIEP----THAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQ 5535

Query: 5062 LVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVMDFFR 5121
            L ++WQQVWLLALER+RKLNDALDRLEEL+EFANFDFD+WRKKYMRWMNHKKSRVMDFFR
Sbjct: 5536 LSARWQQVWLLALERQRKLNDALDRLEELKEFANFDFDVWRKKYMRWMNHKKSRVMDFFR 5595

Query: 5122 RIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAALHPNKD 5181
            RIDKDQDGKITRQEFIDGIL+SKFPT++LEM+AVADIFDRDGDGYIDYYEFVAALHPNKD
Sbjct: 5596 RIDKDQDGKITRQEFIDGILASKFPTTKLEMTAVADIFDRDGDGYIDYYEFVAALHPNKD 5655

Query: 5182 AYKPITDADKIEDEVTRQVAKCKCAKRFQVEQIGDNKYRFFLGNQFGDSQQLRLVRILRS 5241
            AY+P TDADKIEDEVTRQVA+CKCAKRFQVEQIG+NKYRFFLGNQFGDSQQLRLVRILRS
Sbjct: 5656 AYRPTTDADKIEDEVTRQVAQCKCAKRFQVEQIGENKYRFFLGNQFGDSQQLRLVRILRS 5715

Query: 5242 TVMVRVGGGWMALDEFLVKNDPCRAKGRTNMELREKFILADGASQGMAAFRPRGRRSRPS 5301
            TVMVRVGGGWMALDEFLVKNDPCRA+GRTN+ELREKFIL +GASQGM  FR RGRRS+PS
Sbjct: 5716 TVMVRVGGGWMALDEFLVKNDPCRARGRTNIELREKFILPEGASQGMTPFRSRGRRSKPS 5775

Query: 5302 SRGASPNRSTSVSSQAAQAAS--PQVPATTTPKILHPLTRNYGKPWLTNSKMSTPCKAAE 5359
            SR ASP RS+S +SQ+  + +  P  PAT                               
Sbjct: 5776 SRAASPTRSSSSASQSNHSCTSMPSSPAT------------------------------- 5804

Query: 5360 CSDFPVPSAEGTPIQGSKLR--LPGYLSGKGFHSGEDSGLITTAAARVRTQFADSKKTPS 5417
                P    +  P  GSKL+   P + S +   +G+ S   + A+   +T  AD KK+ S
Sbjct: 5805 ----PASGTKVIPSSGSKLKRPTPTFHSSRTSLAGDTSNSSSPASTGAKTNRADPKKSAS 5860

Query: 5418 RPGSRAGSKAGSRASSRRGSDASDFDISEIQSVCSDVETVPQTHRPTPRAGSRPSTAKPS 5477
            RPGSRAGS+AGSRASSRRGSDASDFD+ E QS CSD     ++     +  SR    KPS
Sbjct: 5861 RPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTS---ESSAAGGQGNSRRGLNKPS 5917

Query: 5478 KIPTPQRKS 5486
            KIPT  +K+
Sbjct: 5918 KIPTMSKKT 5926



 Score =  687 bits (1772), Expect = 0.0
 Identities = 815/3917 (20%), Positives = 1653/3917 (42%), Gaps = 407/3917 (10%)

Query: 1166 TYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEV--- 1222
            +Y+  L+ + +  K  Q  E  +   +  LC+ + +  +  ++  L+S   +  +++   
Sbjct: 1812 SYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIIS 1871

Query: 1223 ---DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1279
               +   Q+  ALE + +  +     +  T+  R L F    E     V    N H Q++
Sbjct: 1872 QPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKV---LNQHTQLE 1928

Query: 1280 NRLRDL----------------------EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1317
             RL+DL                      + +   L+ Y D   P+ +   Q++     IQ
Sbjct: 1929 GRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQ 1988

Query: 1318 ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD 1377
                E+++ L+ Q N+Q ML    E+++S  D  ++ A Q  A      LQ M   A+V 
Sbjct: 1989 FFISEHAQDLSPQQNRQ-MLRLLNELQRSFQDILEQTAAQVDAL--QGHLQQMEQEALV- 2044

Query: 1378 SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE 1437
                     + +Q   +   Q+  DL +        +      AG   +  +++  +L++
Sbjct: 2045 ---------KTLQKQQNTCHQQLEDLCSWVGQAERAL------AGHQGRTTQQDLSALQK 2089

Query: 1438 EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQL 1497
             + +  +   ++Q   ++ +  +KD E  G    ++ K+S  E++  +E+L +A      
Sbjct: 2090 NQSDLKDLQDDIQNRATSFATVVKDIE--GFMEENQTKLSPRELTALREKLHQA------ 2141

Query: 1498 FLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG-DVKVEEKIVAERQ 1556
                             ++Q + LQE   +    + K+L+E+ TS    + E+   A+  
Sbjct: 2142 -----------------KEQYEALQEETRV----AQKELEEAVTSALQQETEKSKAAKEL 2180

Query: 1557 QEYKEKLQGICDLLT-------QTENRLIGHQE---------AFMIGDGTVELKKYQSKQ 1600
             E K+K+  + D +T       Q    L G ++         A    DG + + +   K 
Sbjct: 2181 AENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 2240

Query: 1601 EELQKDMQGSAQALAEVVKN-------TENFLKENGEKLSQEDKALIEQKLNEAKIKCEQ 1653
            ++  + M+   Q L    +N        + FL ++G  L+ E++ +++QKL E K   EQ
Sbjct: 2241 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK---EQ 2297

Query: 1654 LNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ-----LEESKTKIENLLDWLSN---VDK 1705
             +    QS+ EL +V T  +++E +K     +     LE S+ ++EN+    S+   +  
Sbjct: 2298 YSTSLAQSEAELKQVQT--LQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPS 2355

Query: 1706 DSERAGTKHKQVIEQNG-THFQEGDGKSAI--------GEEDEVNGNLLETDVDG----- 1751
              +R G+  + VI   G   F    G+  +        G+E    GNL++  +       
Sbjct: 2356 LLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERY 2415

Query: 1752 ----------------------QVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789
                                  Q   + ++L    Q  +A  EK++S   A        Q
Sbjct: 2416 TALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQ 2475

Query: 1790 VLLEKQGQYLSPEEK---EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADY 1846
            +   KQ Q    E +   EKLQK  +++         +     + T S+    +      
Sbjct: 2476 LATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSL 2535

Query: 1847 TEFEHWLQ----QSEQELENLEAGADDINGLMTKL--KRQKSFSEDVISH----KGDLRY 1896
             E    LQ    QS+   E+LE+    I  +   L  K+  S S  VI         L+ 
Sbjct: 2536 AERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQ 2595

Query: 1897 ITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDL 1956
                    LEA +    R     D S T   +Q KL   + RF  L  +     ++LK L
Sbjct: 2596 DIARQKSSLEATREMVTRFMETAD-STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKL 2654

Query: 1957 VDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVA 2016
            + + + +E  S      LQ      S+ L+     D +++    ++ + L  ++  QQ  
Sbjct: 2655 LPQAEMFEHLS----GKLQQFMENKSRMLASGNQPD-QDITHFFQQIQELNLEMEDQQEN 2709

Query: 2017 VEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSV 2076
            ++ L+     L     +L   ++  Q  + ++   + +L K+V ER +        + S 
Sbjct: 2710 LDTLEHLVTELSSCGFALDLCQH--QDRVQNLRKDFTELQKTVKEREKD-------ASSC 2760

Query: 2077 QDGLDEMLDWMGNVESSLKE-QGQVPLNSTA----------------LQDIISKNIMLEQ 2119
            Q+ LDE    +   +  LKE +G +P   T+                L D  SK  ++E+
Sbjct: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820

Query: 2120 DIAGRQSSINAMNE--------KVKKFMETTDPSTAS-----------SLQAKMKDLSAR 2160
                  S  N + E        K    + +   S  S            +Q  M D++ +
Sbjct: 2821 INCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK 2880

Query: 2161 FSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDV-TELSQY 2219
            + +      E    ++ +  ++E     +  +  +LE+K + L  +D       TE  + 
Sbjct: 2881 YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKA 2940

Query: 2220 MQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKE 2279
              ES   FL   +        +KE  + GL     LV    +  ++ +K++++ +  + E
Sbjct: 2941 QAESNKAFLAELEQNSPKIQKVKEALA-GL-----LVTYPNSQEAENWKKIQEELNSRWE 2994

Query: 2280 AVTSC----QEQLD-------AFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDT 2328
              T      Q QL+        FQ     L+ W+ E    + ++ P      +  ++ + 
Sbjct: 2995 RATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPL----SIDPNMLNA 3050

Query: 2329 KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2388
            +K Q ++ LK  E ++  +  ++                  ++   +L G G        
Sbjct: 3051 QKQQVQFMLKEFEARRQQHEQLN------------------EAAQGILTGPGD------- 3085

Query: 2389 WANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMN- 2447
              +   + ++K++  I+  + +    L DK   LN++ S++ +A  +S+   + LQ ++ 
Sbjct: 3086 -VSLSTSQVQKELQSINQKWVE----LTDK---LNSRSSQIDQAIVKSTQYQELLQDLSE 3137

Query: 2448 KTATKWQ----QTPAPTDTEAVKTQVEQNKSFEAELKQ---NVNKVQELKDKLTELLEEN 2500
            K     Q    Q+   T  EAVK Q+E+     ++L+Q    V + Q L D+L+ L+ E 
Sbjct: 3138 KVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQ 3197

Query: 2501 PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKEL 2560
                E    K+ L  +    Q L  L  DR  +L+ +  +  QFQ +  +L+ WL +K+ 
Sbjct: 3198 YLKDEL---KKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQS 3254

Query: 2561 MVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR--PGEDPSLRG 2618
              +   P+S     L +Q Q+ +   +        YE + A G+ +L    PGE+   + 
Sbjct: 3255 QQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE---KR 3311

Query: 2619 IVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA 2678
             ++ QL  +   W+ L+ + +DR   +   + K+ +YQ  +  L   + D   K+ S L 
Sbjct: 3312 TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM-SELR 3370

Query: 2679 VSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGIL 2738
            V+  P  +   L  ++ M  E+++ +  +++  +  + L    + +          +GI 
Sbjct: 3371 VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADE---------DGIR 3421

Query: 2739 KSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ-AWLDTKKEEQNKSHPISAKLDVLE 2797
                 + Q  +   + LQ+   S  +  Q  R+FQ ++ + +K+ +   H +    D L 
Sbjct: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI-FDALG 3480

Query: 2798 SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQ--------GSEKAALQLQLNTIKTN 2849
            S    +K+  K L AQ  + +    + + L   TQ        GS+ + L  Q    +  
Sbjct: 3481 SQACSNKNLEK-LRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQE 3539

Query: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIA 2909
            +     +VK+R N         +  + ++E +  +  + +    ++    D  +G  +I 
Sbjct: 3540 F----LEVKQRVN------SGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIG 3589

Query: 2910 K-LKSLQKEMDQ---HFGMVELLNNTANSLLSVCE--IDKEVVTD------ENKSLIQKV 2957
            +   SLQ +++        + +L     +  + C   +++E   D      E ++L ++ 
Sbjct: 3590 RDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3649

Query: 2958 DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA--YSNKYL 3015
              +TE+  +++  LE    + ++F    K        A+E   +   +G++    + +  
Sbjct: 3650 GKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLA 3709

Query: 3016 TMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDE 3075
                 Q++ +  L+ ++     L Q L+  A        +   +E I    +TL+++V +
Sbjct: 3710 DFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQ 3769

Query: 3076 KCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKL 3135
            + + L+  L   G FQ+ +  + S  A+ ++ + +  P   + + ++ Q +  K   + L
Sbjct: 3770 RIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLL 3829

Query: 3136 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIK 3195
            +   A+ D        +  + E + D   I   LE+L  +  +LL +A AR++Q+E  + 
Sbjct: 3830 DDRKATVDMLQAEGGRIAQSAELA-DREKITGQLESLESRWTELLSKAAARQKQLEDILV 3888

Query: 3196 RLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQD 3255
              ++F+   +  S  L   E+   +  PVG +T  I QQ+   K  + E+IE        
Sbjct: 3889 LAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALE-EDIENHATDVHQ 3947

Query: 3256 VNWLGQGLIQSAAKSTSTQG-LEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDA 3314
               +GQ L  S+  S + QG L   +D + AR+  +  +  ++AA L +AL +   F + 
Sbjct: 3948 AVKIGQSL--SSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED 4005

Query: 3315 LESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3374
               +L+W+ + E+ +++      +  V+  Q  +   L   + +RK  V+   + G+ + 
Sbjct: 4006 EVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALL 4065

Query: 3375 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTI 3434
                  + + I ++L  + +R+  +   +    R LE    +A +F  T E L  WL  +
Sbjct: 4066 KQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREV 4125

Query: 3435 EKRLVNC---EPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDK 3491
            E+ L       P G Q  + ++   + K L+ +++ H   L     + ++L  L     +
Sbjct: 4126 EEELATSGGQSPTGEQIPQFQQ---RQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAR 4182

Query: 3492 DMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLS 3551
            + +   +  +   Y  + +    R + +  A+  ++ + +     + W+ E   KL  L 
Sbjct: 4183 EGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALG 4242

Query: 3552 VQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIK 3611
                  +    Q    +    DI+  K ++D+   +  E+      ++  ++Q+K E++ 
Sbjct: 4243 PIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLI 4302

Query: 3612 ARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQ 3671
             +Y+ I+ L+++    LE+A  L  +   T+EEL  W+++    +    +  +  E+  Q
Sbjct: 4303 QQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQ 4362

Query: 3672 AQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
             Q   ++L++    +K  +D L ++   L EL P    E +E+   +    Y  + + + 
Sbjct: 4363 QQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNP-EEGEMVEEKYQKAENMYAQIKEEVR 4421

Query: 3732 QKVEEIDAAILRSQQ---FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTF 3788
            Q+   +D A+ +S Q   F    +  L  +     +L     I  E D+    +   K+ 
Sbjct: 4422 QRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSA 4481

Query: 3789 TMEILRHKDIIDDLVKSGHKIMTACSEEEK----QSMKKKLDKVLKNYDTICQINSERYL 3844
            T+E+ + +   + L + G +++      +K    + ++ KLD+++  ++ I     ER +
Sbjct: 4482 TVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREI 4541

Query: 3845 QLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEH 3904
            +      L  +FW     L   + +TQ I+  L +P ++   ++QQ E    ++E     
Sbjct: 4542 KFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGL 4601

Query: 3905 KPHIDKMNKTGPQLL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQ 3963
               ++ +   G  L+      E   +++     +  +  + +  K+R   L++A+  + Q
Sbjct: 4602 HEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQ 4661

Query: 3964 FHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRG 4023
            + D +  + + L+  V +L   P +  ++  +K+Q++E K   V++ + Q   E L  +G
Sbjct: 4662 YQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG 4721

Query: 4024 EEMIAR-SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 4082
            E M+ + +  TD+DI    +++ L ++  +WEN+   +  R+ KL   +    +F     
Sbjct: 4722 ELMLKKATDETDRDI----IREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALE 4777

Query: 4083 SLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAA 4142
             L+  +  T++ +        DP V++ +      ++ ++   Q  ++ V   G+EL+ +
Sbjct: 4778 ELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLES 4837

Query: 4143 CGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGG 4202
                D   ++  ++ +N  W+S+ +  ++R  +L+  +Q A  +   ++     +     
Sbjct: 4838 SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMES 4897

Query: 4203 KLASMSPIGTDLETVKQQIE-------ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4255
            +L++  P G   ET ++Q++       +LK  K E Y Q ++  RL     +LL +    
Sbjct: 4898 QLSASKPTGGLPETAREQLDTHMELYSQLKA-KEETYNQLLDKGRL-----MLLSRDDSG 4951

Query: 4256 SDKHTVQD-PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4314
            S   T Q   L+E K  W  +  ++  R+ KLE AL    +FQ++L E + WLT  E  L
Sbjct: 4952 SGSKTEQSVALLEQK--WHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL 5009

Query: 4315 SEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKL 4374
            +   P       +  ++ +H V  N+V AH+  +  +++ GN L   S  ++   ++N L
Sbjct: 5010 NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLL 5069

Query: 4375 EVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4434
              +  RW+ V++++ +R + LD A ++AK FH   + L  WL D E HL +   +   P+
Sbjct: 5070 VSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPD 5129

Query: 4435 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLAR--CPKSAETNIDQDINNLKEKWES 4492
              K QL+ H E       K+  Y + ++ G+ +  +   P+ ++  +D  +  +++KW++
Sbjct: 5130 KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQ-KLDNFLGEVRDKWDT 5188

Query: 4493 VETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEH 4552
            V  K  ER+ KLEEAL  + +F ++LQ  ++WL + E  L         LD V+  +D H
Sbjct: 5189 VCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAH 5248

Query: 4553 KVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4612
            KVF  E+      +  L ++G  L   + + D   +K  L  + +RW+ V +  V +   
Sbjct: 5249 KVFQKELGKRTGTVQVLKRSGREL-IENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSR 5307

Query: 4613 LDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKH 4672
            L+ A K+A+ F +    L+EWL E+E++L     + +D + +++ +  HKEF K +  K 
Sbjct: 5308 LEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR 5367

Query: 4673 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQ 4732
               ++    G  +       D    +   ++ +R +++ +   + + Q +LE AL     
Sbjct: 5368 VDVNSAVAMGEVIL-AVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVA 5426

Query: 4733 FTDALQALIDWLYRVEPQL--AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
              + L+ L+ W+   E  L   + +P+  +ID V  LI  H+ F +E+ ++   V  + +
Sbjct: 5427 NAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTK 5486

Query: 4791 SARE---------LIEGSR------------------DDSSWVKVQMQELSTRWETVCAL 4823
            + +           IE SR                    S     ++ +LS RW+ V  L
Sbjct: 5487 TYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLL 5546

Query: 4824 SISKQTRLEAALRQAEE 4840
            ++ +Q +L  AL + EE
Sbjct: 5547 ALERQRKLNDALDRLEE 5563



 Score =  464 bits (1195), Expect = e-130
 Identities = 690/3701 (18%), Positives = 1500/3701 (40%), Gaps = 386/3701 (10%)

Query: 585  RKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQL----DRTEWG---------SDL 631
            ++ L+K+    QN   +++     +DL +WV + +  L     RT            SDL
Sbjct: 2040 QEALVKTLQKQQNTCHQQL-----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDL 2094

Query: 632  PSVESHLENHK-NVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAEKLHRLESQYAKLL 688
              ++  ++N   +    +++ E  ++E   K+S  ++TA       EKLH+ + QY  L 
Sbjct: 2095 KDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTA-----LREKLHQAKEQYEALQ 2149

Query: 689  NTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 748
              +R  ++ L+     V+ A  +     E E+ + A + +E    I    D+   +    
Sbjct: 2150 EETRVAQKELE---EAVTSALQQ-----ETEKSKAAKELAENKKKIDALLDWVTSVGSSG 2201

Query: 749  DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 808
             Q   N+  +++++   L +   A  T + Y    Q       Q C+ ++   +E  +  
Sbjct: 2202 GQLLTNLPGMEQLSGASLEKG--ALDTTDGYMGVNQAPEKLDKQ-CEMMKARHQELLSQQ 2258

Query: 809  EFF----------------NDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 852
            + F                N   E    L+     ++ +YS   + S  +L+  VQ   +
Sbjct: 2259 QNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ-VQTLQD 2317

Query: 853  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 912
            E ++ LQ      + + +++  ++   +    P      +K    + +  I         
Sbjct: 2318 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI--------- 2368

Query: 913  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNV---LTLWHE- 968
                SH+   + ++ +G + +     F      KE  ++ N ++ + ++     T  H  
Sbjct: 2369 ----SHKGDLRFVTISGQKVLDMENSF---KEGKEPSEIGNLVKDKLKDATERYTALHSK 2421

Query: 969  -----SHINMKSVVSWHYLINEIDRIRA---SNVASIKTML-------PGEHQQVLSNLQ 1013
                 SH+NM  +  +H   N  D ++A   +  A+++ +L       PG  Q+ L+  +
Sbjct: 2422 CTRLGSHLNM-LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTK 2480

Query: 1014 SRFEDFLEDSQESQVFS--GSDITQLEKEVNVCKQYYQELLKS------------AEREE 1059
               E+  E     +       DI ++E E     ++ QE   S            AER  
Sbjct: 2481 QLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSS 2540

Query: 1060 -------QEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1112
                   Q +SV     S +++I    +N E + +  + + + ++ L  ++       KL
Sbjct: 2541 LLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM-------KL 2593

Query: 1113 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLK 1172
            K+++ R K  L   T +    F + A S++   L+ +L  V Q   Q+        +K  
Sbjct: 2594 KQDIARQKSSL-EATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQ---EKES 2649

Query: 1173 TVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN----NIENLISTLKQWRSEVDEKRQV 1228
            ++  +L   +  E L    +  +  +  ++A  N    +I +    +++   E++++++ 
Sbjct: 2650 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQEN 2709

Query: 1229 FHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGI 1288
               LE  + +  +             LD   H+++   L + +  +   +  R +D    
Sbjct: 2710 LDTLEHLVTELSSCGFA---------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSC 2760

Query: 1289 GKSLKYYRDTYHPLDDWIQQVE--------TTQRKIQENQPENSKTLATQLNQQKMLVSE 1340
             + L  +R        W+++ E        +   K  E Q E+ K+L      +  LV E
Sbjct: 2761 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2820

Query: 1341 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1400
            I  K + ++           T  D + +T +    V S   S V           I  + 
Sbjct: 2821 INCKGTSLENL-----IMEITAPDSQGKTGSILPSVGSSVGS-VNGYHTCKDLTEIQCDM 2874

Query: 1401 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEE-----EKKEHVEKAKELQKWVSN 1455
             D+  +Y  L  ++ +  +     L R+EE  K         E KE V K+ +     + 
Sbjct: 2875 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTK 2934

Query: 1456 ISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELE 1515
             ++T+K   ++ K   ++ + +S +I   KE L+  L T          K   EE N   
Sbjct: 2935 -TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRW 2993

Query: 1516 KQVKTLQESYNLLFSESLK-----QLQESQ-------------TSGDVKVEEKIVAERQQ 1557
            ++   +  +      ES       Q  ESQ               G + ++  ++  ++Q
Sbjct: 2994 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 3053

Query: 1558 EYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV 1617
            + +  L+   +   Q   +L    +  + G G V L   Q     +QK++Q   Q   E+
Sbjct: 3054 QVQFMLKEF-EARRQQHEQLNEAAQGILTGPGDVSLSTSQ-----VQKELQSINQKWVEL 3107

Query: 1618 VKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTT---AIK 1674
                 +       + SQ D+A+++    +  ++     ++A   +  +   ++T   A+K
Sbjct: 3108 TDKLNS-------RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVK 3160

Query: 1675 EETEKVAAVK----QLEESKTKIENLLDWLSNV-------DKDSERAGT----------- 1712
            ++ E+ + ++    QL+    + + L D LS +       D+  +R  T           
Sbjct: 3161 QQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDL 3220

Query: 1713 -----KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENL--NQQYQ 1765
                    Q    +   FQ+   +     +D+ +       +  ++   Q  L  N+++Q
Sbjct: 3221 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQ 3280

Query: 1766 KVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAES 1825
            K   QH    S    VI+A   + +L    G     EEK  LQ  + ELK H+E    ++
Sbjct: 3281 KSLNQH----SGSYEVIVAEGESLLLSVPPG-----EEKRTLQNQLVELKNHWEELSKKT 3331

Query: 1826 EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSE 1885
              +        ++ +K+     +   W++  + ++  L    D +  L + L R K+   
Sbjct: 3332 ADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQ-LESSLLRSKAMLN 3390

Query: 1886 DVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSK 1945
            +V   +  L  +  + + ++ +++  +  DG + + +     + + +D  T+  ++    
Sbjct: 3391 EVEKRRSLLEILNSAADILINSSE--ADEDGIRDEKAG----INQNMDAVTEELQAKTGS 3444

Query: 1946 CNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA 2005
               +   L++  + +++ E    G    L+  +A  S+  S     + + L+ Q E  +A
Sbjct: 3445 LEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNK---NLEKLRAQQEVLQA 3501

Query: 2006 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK 2065
            L+ Q+   +   + L + A    DA   L  A+   Q+ L        ++ + VN     
Sbjct: 3502 LEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFL--------EVKQRVNSGCVM 3553

Query: 2066 LQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQ 2125
            ++  L         + EM   + +++  L   G +  ++ +LQ  I    +    I   +
Sbjct: 3554 MENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLK 3613

Query: 2126 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2185
              I A   + +  +E         L+ +++ L+ +  + + + K   A+ E+L+  +   
Sbjct: 3614 LDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK---ARQEQLELTLGRV 3670

Query: 2186 ENLSEKLQTFLETKTQAL----------TEVDVPGKDVTELSQYMQESTSEFLEHKKHLE 2235
            E+   KL+   +  T A           TEV++  + + +   + +E         + + 
Sbjct: 3671 EDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVN 3730

Query: 2236 -----VLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2290
                 ++ S  K+    GL  D   +  + N L+KK   +   I + +EA+  C +    
Sbjct: 3731 GLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKK---VAQRIAQLQEALLHCGK---- 3783

Query: 2291 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSG 2349
            FQ  ++ L SW+ +T + +   +P      + K+ +++ K LQ     +   +  +   G
Sbjct: 3784 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843

Query: 2350 ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMTDISHG 2407
              +    SA     + I             G   + E  W        + +K + DI   
Sbjct: 3844 GRIAQ--SAELADREKIT------------GQLESLESRWTELLSKAAARQKQLEDI--- 3886

Query: 2408 YEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2467
                 L+L  +  E    +S      E+  A                  P  T T  ++ 
Sbjct: 3887 -----LVLAKQFHETAEPISDFLSVTEKKLA---------------NSEPVGTQTAKIQQ 3926

Query: 2468 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2527
            Q+ ++K+ E +++ +   V +   K+ + L       E     + +  + +++ E+    
Sbjct: 3927 QIIRHKALEEDIENHATDVHQAV-KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3985

Query: 2528 IDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQ 2587
              +   L+++ +N   F   E ++  WL E E  +S +       ++L+ Q      L +
Sbjct: 3986 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNE 4045

Query: 2588 EFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQ 2647
            E   RK   +Q    GQ +L +   +  L  +++E+L  +  ++  +T   S     ++Q
Sbjct: 4046 EIVNRKKNVDQAIKNGQALLKQTTGEEVL--LIQEKLDGIKTRYADITVTSSKALRTLEQ 4103

Query: 2648 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI 2707
            A   +T++QS    L+  L +++ +L++S   S   + + Q  +  +++K+E+ + +  +
Sbjct: 4104 ARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVL 4163

Query: 2708 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2767
                 +   L  LV     +  L + +    + +K V       V  + +A   S Q++Q
Sbjct: 4164 DTVNEVSRALLELVPWR-AREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQ 4222

Query: 2768 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 2827
             +    AW+   K +     PI  + D   + ++  K FS  +       ++  +    +
Sbjct: 4223 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 4282

Query: 2828 LLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2887
                   +K  LQ +  ++   ++  +    ER  +L+ +     ++ E  E L PWI++
Sbjct: 4283 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 4342

Query: 2888 CQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2946
             +  + ++    +D  +      +++ L++ + +H   ++ L      L  +   + E+V
Sbjct: 4343 TRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMV 4402

Query: 2947 TDENKSLIQKVDMVTEQLHSKKFCLE---NMTQKFKEFQEVSKESKRQLQCAKEQLDIH- 3002
             ++ +        + E++  +   L+   + + +  EF +  +     L+    +L +  
Sbjct: 4403 EEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPP 4462

Query: 3003 ------DSLGSQAYSNKYLTM-LQTQQKSLQALKHQ----VDLAKRLAQDLVVEASDSKG 3051
                  D +      NK  T+ L+  Q S +ALK +    +  ++   +DL      +K 
Sbjct: 4463 LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLA-----AKE 4517

Query: 3052 TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSM 3111
              D L Q+    ++    +++ + K  FL+  L+    F   +  + +   +  D +  +
Sbjct: 4518 IQDKLDQMVFFWEDIKARAEEREIK--FLDV-LELAEKFWYDMAALLTTIKDTQDIVHDL 4574

Query: 3112 APVGRDAETLQKQKETIKAFLKKLEALMASNDNAN-KTCKMMLATEETSPDLVGIKRDLE 3170
               G D   +++Q E  +   ++ + L    +        ++ A  ET  +   +++ ++
Sbjct: 4575 ESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGET--EKPEVRKSID 4632

Query: 3171 ALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETET 3230
             ++     L    + R E++E  ++   ++   L+     L        +  PVG +  T
Sbjct: 4633 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNT 4692

Query: 3231 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3290
            +  QLN  K F K E+   Q + + +N  G+ +++ A   T    +   L ++   W+ L
Sbjct: 4693 VKDQLNEMKEF-KVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENL 4751

Query: 3291 NKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQK 3350
             +K+A R  +L+ ALL  G+FQ ALE L+SW+  TEEL+  Q+P S + KV++ ++ +  
Sbjct: 4752 GEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHH 4811

Query: 3351 LLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQL 3410
            +L+  +   ++TVE + + G ++  ++   D   +  +L  ++  WE++L K E R +QL
Sbjct: 4812 VLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQL 4871

Query: 3411 EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNK 3470
            +     AQ FH  +E     LT +E +L   +P G       EQ+  H  L   +    +
Sbjct: 4872 QSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE 4931

Query: 3471 HLHQAVSIGQSLKVLSSRED----KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3526
              +Q +  G+ +  L SR+D        QS     Q W++ +  K   R   L++AL  A
Sbjct: 4932 TYNQLLDKGRLM--LLSRDDSGSGSKTEQSVALLEQKWHV-VSSKMEERKSKLEEALNLA 4988

Query: 3527 KIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALL 3586
              F     E +NWL      L+  S        +  Q  E +V   ++   +  + +   
Sbjct: 4989 TEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQ 5048

Query: 3587 NGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3646
             G +L   +   +V++I++ L ++++R++ + + S +  ++L+ A + A++ H   ++L 
Sbjct: 5049 TGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLI 5108

Query: 3647 TWLDKVEVELLSYETQVLKGEEASQAQM-RPKELKKEAKNNKALLDSLNEVSSALLE--L 3703
             WL+  E  L S E ++    +  + Q+ + KE +K     + + D+      AL E  L
Sbjct: 5109 DWLEDAESHLDS-ELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTL 5167

Query: 3704 VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEK 3763
            +P  +++ L+  + E  +++  V     ++  +++ A+L S QF  A  A + W+ + E 
Sbjct: 5168 LPEDSQK-LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEP 5226

Query: 3764 KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKK 3823
            +L     +  + D     +   K F  E+ +    +  L +SG +++   S ++   +K 
Sbjct: 5227 QLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-SRDDTTWVKG 5285

Query: 3824 KLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALE 3883
            +L ++   +DT+C+++  +  +LE+A      F +T   L  WL+E +  +    A   +
Sbjct: 5286 QLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDD 5345

Query: 3884 YETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAA-----DT 3938
             E L+   + H++  + + E +  ++     G  +L +   +  +  + ++       + 
Sbjct: 5346 TEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEE 5405

Query: 3939 LYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3998
            + +  K+  ++   AL E ++ +    + +  I  +   +++R ++P  I   ++++K  
Sbjct: 5406 VLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEP--IPQNIDRVKAL 5463

Query: 3999 ISENKNVSVDMEKLQP----LYETLKQRGEEMI-------ARSGGTDKDIS--------- 4038
            I+E++    +M + QP    + +T K++  E         +RSGG  K +S         
Sbjct: 5464 IAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHAPFIEKSRSGGR-KSLSQPTPPPMPI 5522

Query: 4039 ---AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEK 4076
               ++A   +++Q+   W+ +  L  ER+ KL D ++  E+
Sbjct: 5523 LSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEE 5563



 Score =  420 bits (1080), Expect = e-116
 Identities = 582/3160 (18%), Positives = 1263/3160 (39%), Gaps = 295/3160 (9%)

Query: 2067 QITLTRSLSVQ--DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2124
            Q   TR L ++  + L   L  + N+E   K+   + LN   LQD++ +  +LE+++   
Sbjct: 1795 QNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDL 1854

Query: 2125 QSSINAMNEKVKKFM----ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEEL-- 2178
             + ++   E V + +    +        +L+   K+L    S  S      L   +    
Sbjct: 1855 TTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVE 1914

Query: 2179 --KTKV----ELFENLSEKLQTFLETKTQAL------TEVDVPGKDVTELSQYMQESTSE 2226
              KTKV       E   + L+ ++  K   L      +E+DV   ++  L QY ++    
Sbjct: 1915 IEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC-LQQY-EDLKQP 1972

Query: 2227 FLEHKKHLEVL----HSLLKEISSHGLPSDKALVLEKTNNLSKKFKE-MEDTI------- 2274
              E K  L+ L       + E +    P     +L   N L + F++ +E T        
Sbjct: 1973 MAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQ 2032

Query: 2275 -----KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLG---KSLE 2326
                  E++  V + Q+Q +     ++ L SW+ +  + +   Q     +DL    K+  
Sbjct: 2033 GHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQS 2092

Query: 2327 DTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2386
            D K LQ+           + N   S   ++  +                   EG     +
Sbjct: 2093 DLKDLQD----------DIQNRATSFATVVKDI-------------------EGFMEENQ 2123

Query: 2387 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL-SKLQKAQEES--------- 2436
               + + LT++++ +      YE L    +    EL   + S LQ+  E+S         
Sbjct: 2124 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 2183

Query: 2437 ----SAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2492
                 A++ W+  +  +  +   T  P   +     +E+      +    VN+  E  DK
Sbjct: 2184 KKKIDALLDWVTSVGSSGGQ-LLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDK 2242

Query: 2493 LTELLEENPD------------TPEA------------PRWKQMLTEIDSKWQELNQLTI 2528
              E+++                T  A            P  +QML       Q+L +L  
Sbjct: 2243 QCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQ------QKLGELKE 2296

Query: 2529 DRQQKLEESSNNLTQFQTVEAQLKQ----------WLVEKELMVSVLGPLSIDPNMLNTQ 2578
                 L +S   L Q QT++ +L++          WL   E  +  +      P  L + 
Sbjct: 2297 QYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSL 2356

Query: 2579 RQQVQILLQEFATRKPQYEQLTAAGQGILS-----RPGEDPS-LRGIVKEQLAAVTQKWD 2632
             ++     ++  + K     +T +GQ +L      + G++PS +  +VK++L   T+++ 
Sbjct: 2357 LKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYT 2416

Query: 2633 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLA--VSTHPDAMNQQL 2690
            +L  + +     ++  + +  Q+Q+   SL   +   +  +   L+  V++ P  + +QL
Sbjct: 2417 ALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQL 2476

Query: 2691 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYL-KAELSRQLEGILKSFKDVEQKAE 2749
             T +++++E+ + +  ++  Q +  D+  +  E       +    + IL  F+ +     
Sbjct: 2477 ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLA 2536

Query: 2750 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2809
                 LQ A A S   Q+        +   ++        S    V++  +  +    + 
Sbjct: 2537 ERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQD 2596

Query: 2810 LTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 2869
            +  Q    E T       +     +  A LQ +L  +   ++    Q +E+E+ LK+ L 
Sbjct: 2597 IARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLP 2656

Query: 2870 KALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE--NSIAKLKSLQKEMDQHFGMVEL 2927
            +A    E  E L   + +   N   +    +  + +  +   +++ L  EM+     ++ 
Sbjct: 2657 QA----EMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDT 2712

Query: 2928 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2987
            L +     LS C    ++   +++                   ++N+ + F E Q+  KE
Sbjct: 2713 LEHLVTE-LSSCGFALDLCQHQDR-------------------VQNLRKDFTELQKTVKE 2752

Query: 2988 SKRQLQCAKEQLDIHDSL--GSQAYSNKYLTMLQTQQKSLQA--LKHQVDLAKRLAQD-- 3041
             ++     +EQLD    L    Q +  +    +   + S+ A  L+ Q++  K L  D  
Sbjct: 2753 REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWA 2812

Query: 3042 ---LVVEASDSKGTSDVLLQVETIAQE---------------------HSTLSQQVDEKC 3077
                +VE  + KGTS   L +E  A +                     + T     + +C
Sbjct: 2813 SKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQC 2872

Query: 3078 SFLET-----KLQGIGH-FQNTIREMFSQFAEFDDE-----------------LDSMAPV 3114
               +      KL G+ H  Q +++ + ++  E   E                 +D+M+  
Sbjct: 2873 DMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP 2932

Query: 3115 GRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSK 3174
             +  ET++ Q E+ KAFL +LE          +    +L T   S +    K+  E L+ 
Sbjct: 2933 TK-TETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNS 2991

Query: 3175 QCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQ 3234
            +  +  +   AR+ Q+E +   L  F +   +    L + E      GP+ ++   +N Q
Sbjct: 2992 RWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 3051

Query: 3235 LNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK-STSTQGLEHDLDDVNARWKTLNKK 3293
                + F  +E E  + + + +N   QG++      S ST  ++ +L  +N +W  L  K
Sbjct: 3052 KQQVQ-FMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDK 3110

Query: 3294 VAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQ 3353
            +  R++Q+ +A++   ++Q+ L+ L   +    + ++ Q   S + + VK Q++E   ++
Sbjct: 3111 LNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIR 3170

Query: 3354 RLLDDRKSTVEVIKREGEKIAT-TAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEG 3412
              L+     V+  +   ++++    E   K ++ K+L  +    + L + A  R  +L+ 
Sbjct: 3171 SDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQA 3230

Query: 3413 ISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3472
                 QQF +  + L  WL   + +     PI  +  +L+ Q+ +++  +  +  H+   
Sbjct: 3231 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 3290

Query: 3473 HQAVSIGQSLKV-LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGE 3531
               V+ G+SL + +   E+K  +Q++L   +  + E+ +K+  R   L+  +  A+ +  
Sbjct: 3291 EVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQW 3350

Query: 3532 DEVELMNWLNEVHDKLSKLSV-------------QDYSTEGLWKQQSELRVLQE--DILL 3576
               +L+ W+ +   K+S+L V                    + K++S L +L    DIL+
Sbjct: 3351 HVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI 3410

Query: 3577 RKQNVDQALLN----GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQAL 3632
                 D+  +     G+        +E+      LE +  R ++  +   ++ K +E A 
Sbjct: 3411 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 3470

Query: 3633 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMR--PKELKKEAKNNKALL 3690
                   +   + C+      +E L  + +VL+  E     +R   + L ++A +     
Sbjct: 3471 HQLEIFDALGSQACS---NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDAS 3527

Query: 3691 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3750
              L++   A  E +  + R     ++ E+             K+E I        QF   
Sbjct: 3528 QLLHQAEVAQQEFLEVKQRVNSGCVMMEN-------------KLEGIG-------QFHCR 3567

Query: 3751 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIM 3810
                 S + + + +L  +G I  + D   +Q++  + F  +I   K  I+        ++
Sbjct: 3568 VREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHML 3627

Query: 3811 TACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTET 3870
                  +   +K++L+ + K    + +    R  QLE     V  F+   + L    T  
Sbjct: 3628 EEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAA 3687

Query: 3871 QSIISQLPAPALEYETLRQQQEEHRQL-RELIAEHKPHIDKMNKTGPQLLELSPGEGFSI 3929
            +   +       E E + QQ  + +   +E +   +  + ++N  G  L++ S G+   +
Sbjct: 3688 EEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ-SAGKDCDV 3746

Query: 3930 Q---EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPP 3986
            Q         +  ++ + + V +R   L EA+    +F D ++ +L  L    E +    
Sbjct: 3747 QGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQK 3806

Query: 3987 SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKL 4046
              SAE + +K QI E K +   ++  +   + L+  G  +   +   D++     +  +L
Sbjct: 3807 PPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADRE----KITGQL 3862

Query: 4047 DQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPS 4106
            + +   W  + +    R+ +L D++ LA++F      +   +  T+  + + E  G   +
Sbjct: 3863 ESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTA 3922

Query: 4107 VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLN 4166
             ++QQ    + + E+I+    ++   + +G  L +     ++ ++ + ID L + +  + 
Sbjct: 3923 KIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQ 3982

Query: 4167 KAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQ 4226
                 +   L++A+  A  + +    V +W+     KL+S+       + + +Q  +   
Sbjct: 3983 DRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLA 4042

Query: 4227 FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKL 4286
               E   ++  +++     + LLK+ T E +   +Q+ L  +K  +  +          L
Sbjct: 4043 LNEEIVNRKKNVDQAIKNGQALLKQTTGE-EVLLIQEKLDGIKTRYADITVTSSKALRTL 4101

Query: 4287 EGALLALGQFQHALDELLAWLTHTEGLLSE---QKPVGGDPKAIEIELAKHHVLQNDVLA 4343
            E A     +FQ   +EL  WL   E  L+    Q P G   + I     +   L+ +V+ 
Sbjct: 4102 EQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTG---EQIPQFQQRQKELKKEVME 4158

Query: 4344 HQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4403
            H+  ++ VN+    L+E         L   +   N++++ V +   QR  ++D A+++++
Sbjct: 4159 HRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQ 4218

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQK 4463
             +    +    W+ +T+R L+A  P+    +    QL V           +++   L   
Sbjct: 4219 QYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSH 4278

Query: 4464 GQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFIN 4523
              ++   C +  +T + +   +L +++E++    +ER  +LE A  L  +F  + ++   
Sbjct: 4279 RSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 4338

Query: 4524 WLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4583
            W+ +    +     P++  + +  Q +E +     +  H+  I +L K G  LK  + ++
Sbjct: 4339 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 4398

Query: 4584 DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ---FHEAWSKLMEWLEESEKS 4640
               +++      ++ + ++ + + +R  +LD+A  ++ Q   FH+    ++E LE     
Sbjct: 4399 G-EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSR 4457

Query: 4641 LDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---K 4697
            L     I  + DKI+  ++ +K     L      ++   R G  L  ++  AD +L   +
Sbjct: 4458 LRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKE 4517

Query: 4698 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4757
            + D L ++   W+ I  ++ ER+ K  + L  + +F   + AL+  +   +  + + +  
Sbjct: 4518 IQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP 4577

Query: 4758 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELSTR 4816
              D  ++   ++  +  ++E       ++ ++    +LI      +   V+  + E++  
Sbjct: 4578 GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA 4637

Query: 4817 WETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLI 4876
            WE +      +  +LE A++ A ++   + A+ +WL      L     +  D + ++  +
Sbjct: 4638 WENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQL 4697

Query: 4877 DQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDS-ITTIKHWITIIRARFEEVLAWAKQ 4935
            ++ KEF  ++ +++ E+ K    G+ +L     ++    I+  +T ++  +E +      
Sbjct: 4698 NEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAH 4757

Query: 4936 HQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFME 4995
             Q +L  AL  L   Q  LE L++WL   E  L    +  I  + + ++  +A+H     
Sbjct: 4758 RQHKLEGALLALGQFQHALEELMSWLTHTEELL--DAQRPISGDPKVIEVELAKHHVLKN 4815

Query: 4996 EMTRKQPDVDKVTKT-----YKRRAADPSSLQSHIPVLDK 5030
            ++   Q  V+ V K            D SSL+S +  +++
Sbjct: 4816 DVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQ 4855



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 37/141 (26%), Positives = 63/141 (44%), Gaps = 29/141 (20%)

Query: 279  MVNYLIQWIRHHVTTMSERT---FPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLY 335
            ++  L+ WI+   TT+ +R     P N   +KAL  ++  F E E+  K+ +  ++ + Y
Sbjct: 5430 LLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME-EMTRKQPDVDRVTKTY 5488

Query: 336  KLLEI------WIEF----GRIKLLQGYHP---------------NDIEKEWGKLIIAML 370
            K   I      +IE     GR  L Q   P               N +   W ++ +  L
Sbjct: 5489 KRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLAL 5548

Query: 371  EREKALRPEVERLEMLQQIAN 391
            ER++ L   ++RLE L++ AN
Sbjct: 5549 ERQRKLNDALDRLEELKEFAN 5569


>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
          Length = 3062

 Score = 2291 bits (5938), Expect = 0.0
 Identities = 1169/1170 (99%), Positives = 1170/1170 (100%)

Query: 382  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 441
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115

Query: 442  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 501
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175

Query: 502  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 561
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235

Query: 562  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 621
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295

Query: 622  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 681
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355

Query: 682  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 741
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415

Query: 742  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 801
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475

Query: 802  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 861
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535

Query: 862  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 921
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595

Query: 922  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 981
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655

Query: 982  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1041
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715

Query: 1042 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1101
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775

Query: 1102 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1161
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835

Query: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1221
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895

Query: 1222 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1281
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955

Query: 1282 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1341
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015

Query: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075

Query: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1461
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK
Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135

Query: 1462 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1521
            DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL
Sbjct: 1136 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1195

Query: 1522 QESYNLLFSESLKQLQESQTSGDVKVEEKI 1551
            QESYNLLFSESLKQLQESQTSGDVKVEEK+
Sbjct: 1196 QESYNLLFSESLKQLQESQTSGDVKVEEKL 1225



 Score = 62.8 bits (151), Expect = 9e-09
 Identities = 201/1034 (19%), Positives = 407/1034 (39%), Gaps = 152/1034 (14%)

Query: 3515 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3574
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------WG--SDLPSV-ESH 311

Query: 3575 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3627
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371

Query: 3628 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3682
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425

Query: 3683 AKNNKALLDS----LNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3726
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485

Query: 3727 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3784
            +D    T  +  +  AI R    D+++   +  + +  ++ M   +  L+   T A L +
Sbjct: 486  NDAKEATDYLRNLKDAIQRKYSCDRSSS--IHKLEDLVQESMEEKEELLQYKSTIANL-M 542

Query: 3785 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3837
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 543  GKAKTIIQLKPRNS-DCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601

Query: 3838 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3887
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661

Query: 3888 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELSP------GEGFSIQEKYVAADTLY 3940
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718

Query: 3941 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 3997
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778

Query: 3998 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4057
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835

Query: 4058 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4104
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886

Query: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSIDELNSAW 4162
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945

Query: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4219
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003

Query: 4220 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4279
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057

Query: 4280 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD--------PKAIEIEL 4331
            + R+     A L + +F        A +T    L+++     GD         K++E E 
Sbjct: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEK 1113

Query: 4332 AKH----HVLQNDVLAHQSTVEAVNKAGNDLI--ESSAGEEASNLQNKLEVLNQRWQNVL 4385
             +H      LQ  V     T++   KAG      +  + EE S  + +L    Q  Q  L
Sbjct: 1114 KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFL 1173

Query: 4386 EK-----TEQRKQQLDGALRQAKG-----FHGEIEDLQQWLTDTE---RHLLASKPLGGL 4432
             K     T++ + +L+  ++  +      F   ++ LQ+  T  +      L     G +
Sbjct: 1174 AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTI 1233

Query: 4433 PETAKEQLNVHMEV 4446
             +T  E L+V   V
Sbjct: 1234 DQTTGEVLSVFQAV 1247



 Score = 58.5 bits (140), Expect = 2e-07
 Identities = 156/922 (16%), Positives = 365/922 (39%), Gaps = 121/922 (13%)

Query: 956  EQQYQNVLTLWHESHINMKSVVSWHY-LINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1014
            E++ + V   W E + N+     +H  L+ E+D+ +  N+ S++ +     Q +L N  +
Sbjct: 391  EKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIA---EQLLLENHPA 446

Query: 1015 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN 1074
            R           + +  +  TQ    + +C+          E+  +E + Y  + ++ + 
Sbjct: 447  RLT--------IEAYRAAMQTQWSWILQLCQ--------CVEQHIKENTAYFEFFNDAKE 490

Query: 1075 IRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFF 1134
                L N +D + R+         +H+    + E  + K+EL + K  +  +  K +   
Sbjct: 491  ATDYLRNLKDAIQRKYSCD-RSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 549

Query: 1135 SQAAASSSVPTLRS----------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAA 1184
                 +S  P   S          ++ + +   ++    ++++  K K ++         
Sbjct: 550  QLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS-----PTGN 604

Query: 1185 EALVK--LYETKLCEEEAVIADKNNIENLISTLKQWR-SEVDEKRQV-FHALEDELQKAK 1240
            EA+V    +      +EAV       +   + L  W  S ++ K  V +H L +E+ + +
Sbjct: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIR 664

Query: 1241 AISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL----RDLEGIGKSLKYYR 1296
            A +    KT    +     H++    L  R+++              D+  + K +   +
Sbjct: 665  ASNVASIKTMLPGE-----HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK 719

Query: 1297 DTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQ-KYA 1355
              Y  L      +++ +R+ QE    N            + +SE+   + +++ C+ +  
Sbjct: 720  QYYQEL------LKSAEREEQEESVYN------------LYISEVRNIRLRLENCEDRLI 761

Query: 1356 EQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLII---QEFMDLRTRYTALVT 1412
             Q    ++  +L    +R  +  Q+K   +  R++     I    +EF       +++ T
Sbjct: 762  RQIRTPLERDDLHESVFR--ITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT 819

Query: 1413 LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFS 1472
            L ++        L  + +    +      +++K K     V+ + K  + AE   K  + 
Sbjct: 820  LRSE--------LNVVLQNMNQVYSMSSTYIDKLKT----VNLVLKNTQAAEALVKL-YE 866

Query: 1473 KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1532
             +    E +   K  +   + T++ + ++      DE+R         LQ++   +  E 
Sbjct: 867  TKLCEEEAVIADKNNIENLISTLKQWRSE-----VDEKRQVFHALEDELQKA-KAISDEM 920

Query: 1533 LKQLQESQTSGDVKVEEKI-VAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1591
             K  +E     D   E+   + ER Q    ++      L      L  +++ +   D  +
Sbjct: 921  FKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWI 980

Query: 1592 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1651
            +  + ++ Q ++Q++   +++ LA  +   +  + E   K S+ D+     +   A +K 
Sbjct: 981  Q--QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD 1038

Query: 1652 EQLNLKAEQSKKELDKVVTTAIKEETEKVAA---VKQLEESKTKIENLLDWLSNVDK--- 1705
             +L     ++   +D    + +K    + +A   +++  + +T+   L+  ++   K   
Sbjct: 1039 YELQTMTYRAM--VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1096

Query: 1706 DS-ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1764
            DS +R   + K + E+   H ++        E  +   N+ +T  D +           +
Sbjct: 1097 DSLKRLEEEEKSLEEEKKEHVEKAK------ELQKWVSNISKTLKDAEKAG-----KPPF 1145

Query: 1765 QKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAE 1824
             K K   E+I ++ + +  A Q+ Q+ L K G  ++ EE+ +L+K +K L+  Y    +E
Sbjct: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1205

Query: 1825 SEKKMKLTHS-----LQEELEK 1841
            S K+++ + +     ++E+L+K
Sbjct: 1206 SLKQLQESQTSGDVKVEEKLDK 1227



 Score = 56.6 bits (135), Expect = 7e-07
 Identities = 189/951 (19%), Positives = 370/951 (38%), Gaps = 161/951 (16%)

Query: 4148 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4207
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308

Query: 4208 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4254
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368

Query: 4255 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4311
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426

Query: 4312 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4345
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486

Query: 4346 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4403
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4461
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600

Query: 4462 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4516
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651

Query: 4517 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4562
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710

Query: 4563 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4616
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766

Query: 4617 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4676
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817

Query: 4677 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4735
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856

Query: 4736 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4788
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913

Query: 4789 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4845
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973

Query: 4846 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4904
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++     +   
Sbjct: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYS 1033

Query: 4905 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 4964
            A      + T+ +   +   +   V       ++R   + A LI  QE ++    +    
Sbjct: 1034 ATVKDYELQTMTYRAMVDSQQKSPV-------KRRRMQSSADLII-QEFMDLRTRYTALV 1085

Query: 4965 ETTLTDKDK---EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYK 5012
             T +T   K   + + +  EE K+L  E +  +E+    Q  V  ++KT K
Sbjct: 1086 -TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135



 Score = 55.1 bits (131), Expect = 2e-06
 Identities = 107/564 (18%), Positives = 239/564 (42%), Gaps = 48/564 (8%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3220
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762

Query: 3221 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820

Query: 3277 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3334
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880

Query: 3335 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3390
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939

Query: 3391 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3450
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E      +    + SK
Sbjct: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 999

Query: 3451 -LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3509
             L  Q+ Q K L  +I      + +     +      S   KD     + +  +  ++ Q
Sbjct: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY----SATVKDYELQTMTYRAM--VDSQ 1053

Query: 3510 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3569
            +KS  +   +Q    +A +  ++ ++L      +   +++     ++ + L + + E + 
Sbjct: 1054 QKSPVKRRRMQS---SADLIIQEFMDLRTRYTALVTLMTQYI--KFAGDSLKRLEEEEKS 1108

Query: 3570 LQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT-- 3627
            L+E+   +K++V++A     + L++   +    ++D  +A K  +    K+S++   T  
Sbjct: 1109 LEEE---KKEHVEKA-----KELQKWVSNISKTLKDAEKAGKPPFSK-QKISSEEISTKK 1159

Query: 3628 --LEQALQLARRLHSTHEELCTWLDKVEVE----LLSYETQVLKGEEASQAQ--MRPKEL 3679
              L +ALQ  +   + H +  T  ++ E+E     L     +L  E   Q Q      ++
Sbjct: 1160 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219

Query: 3680 KKEAKNNKALLDSLNEVSSALLEL 3703
            K E K +K +  ++++ +  +L +
Sbjct: 1220 KVEEKLDKVIAGTIDQTTGEVLSV 1243



 Score = 47.8 bits (112), Expect = 3e-04
 Identities = 186/1109 (16%), Positives = 432/1109 (38%), Gaps = 198/1109 (17%)

Query: 1178 LKNTQAAEALVK--LYETKLCEEEAVIADKNNIENLISTLK------QWRSEV------- 1222
            LK  Q  + L+K  L +  L EEE  +    ++ N +  ++      +W S++       
Sbjct: 253  LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 312

Query: 1223 DEKRQVFHALED---ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQID 1279
            +  + V  A+E+    L++AK    +M    K        + EK  +L  ++  +     
Sbjct: 313  ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLT------YAEKLHRLESQYAKLLNTSR 366

Query: 1280 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1339
            N+ R L+ +   +   R T   +  W+ + E  + ++  +  E +  +A + +    L+ 
Sbjct: 367  NQERHLDTLHNFVS--RATNELI--WLNEKE--EEEVAYDWSERNTNIARKKDYHAELMR 420

Query: 1340 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1399
            E++ K+  +   Q+ AEQ         L    YRA + +Q    ++  +        +++
Sbjct: 421  ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQC-------VEQ 473

Query: 1400 FMDLRTRYTALVT---LMTQYIKFAGDSLKRLEEEEKS-----LEEEKKEHVEKAKELQK 1451
             +   T Y          T Y++   D+++R    ++S     LE+  +E +E+ +EL +
Sbjct: 474  HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQ 533

Query: 1452 WVSNISKTLKDAEKAG--KPPFSKQKISSE------------EISTKKEQL--------- 1488
            + S I+  +  A+     KP  S   + +             EI+  K+           
Sbjct: 534  YKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHR 593

Query: 1489 ----------SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN---------LLF 1529
                      +EA+     F     +K   +  N +E+Q + +   ++         + +
Sbjct: 594  AKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSW 653

Query: 1530 SESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDG 1589
               + ++   + S    ++  +  E QQ        + +L ++ E+ L   QE+ +    
Sbjct: 654  HYLINEIDRIRASNVASIKTMLPGEHQQV-------LSNLQSRFEDFLEDSQESQVFSGS 706

Query: 1590 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKI 1649
             +          +L+K++    Q   E++K+ E           ++++++    ++E + 
Sbjct: 707  DIT---------QLEKEVNVCKQYYQELLKSAER---------EEQEESVYNLYISEVR- 747

Query: 1650 KCEQLNLKAEQSKKELDKVVTTAIKEET--EKVAAVKQLEESKTKIENLLDWLSNVDKDS 1707
                + L+ E  +  L + + T ++ +   E V  + + E+ K ++E L D L  +    
Sbjct: 748  ---NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKC 804

Query: 1708 ERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKV 1767
            E                F +    S++              +  ++    +N+NQ Y   
Sbjct: 805  EE--------------FFSQAAASSSV------------PTLRSELNVVLQNMNQVYSMS 838

Query: 1768 KAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKN-MKELKVHYETALAESE 1826
                +K+ + +  V+  TQ+A+ L++     L  EE     KN ++ L    +   +E +
Sbjct: 839  STYIDKLKTVN-LVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVD 897

Query: 1827 KKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSED 1886
            +K ++ H+L++EL+K  A   E     ++ + + +  +  AD +      ++R ++    
Sbjct: 898  EKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL------VERWQNVHVQ 951

Query: 1887 VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKC 1946
            + +   DL  I   G  +     +    D        T R++Q   ++  +  ++L ++ 
Sbjct: 952  IDNRLRDLEGI---GKSLKYYRDTYHPLDDWIQQVETTQRKIQ---ENQPENSKTLATQL 1005

Query: 1947 NVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKAL 2006
                N  K LV + +  +       + +  C+  A     E  +   K+ + Q    +A+
Sbjct: 1006 ----NQQKMLVSEIEMKQ-------SKMDECQKYA-----EQYSATVKDYELQTMTYRAM 1049

Query: 2007 QGQISSQQVAVEKLKKTAEVL----LDAR---GSLLPAKNDIQKTLDDIVGRYEDLSKSV 2059
                    V   +++ +A+++    +D R    +L+       K   D + R E+  KS+
Sbjct: 1050 VDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSL 1109

Query: 2060 NERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQ 2119
             E  ++            +   E+  W+ N+  +LK+  +      + Q I S+ I  ++
Sbjct: 1110 EEEKKE----------HVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1159

Query: 2120 DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELK 2179
            +      ++  +   + K  +       + L+ ++K L   ++       E+L +++E +
Sbjct: 1160 E--QLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL---FSESLKQLQESQ 1214

Query: 2180 TK--VELFENLSEKLQTFLETKTQALTEV 2206
            T   V++ E L + +   ++  T  +  V
Sbjct: 1215 TSGDVKVEEKLDKVIAGTIDQTTGEVLSV 1243



 Score = 46.2 bits (108), Expect = 9e-04
 Identities = 178/1077 (16%), Positives = 401/1077 (37%), Gaps = 210/1077 (19%)

Query: 3643 EELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLE 3702
            ++L  W+D+++V+L   E     G +    +   +  K   +  +    SL E   + ++
Sbjct: 283  QDLLNWVDEMQVQLDRTEW----GSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQ 338

Query: 3703 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3762
            +         EK+   +++  +L++ +  Q+   +D        F   A  EL W+ E E
Sbjct: 339  MTAPLKLTYAEKLHRLESQYAKLLNTSRNQE-RHLDTL----HNFVSRATNELIWLNEKE 393

Query: 3763 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3822
            ++     ++  +  + +  +  +K +  E++R                            
Sbjct: 394  EE-----EVAYDWSERNTNIARKKDYHAELMR---------------------------- 420

Query: 3823 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ-LPAPA 3881
             +LD+  +N  ++ +I  +  L+   A+  +  +    +  W W+ +    + Q +    
Sbjct: 421  -ELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 479

Query: 3882 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3941
              +E     +E    LR L                           +IQ KY    +   
Sbjct: 480  AYFEFFNDAKEATDYLRNLKD-------------------------AIQRKYSCDRSSSI 514

Query: 3942 QIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE----------RLRQPPSISAE 3991
               ED+ + ++   E +    Q+   I  ++   + I++          +   P     +
Sbjct: 515  HKLEDLVQESMEEKEEL---LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICD 571

Query: 3992 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
              +I+  I ++    +     +  ++ +   G E +  S         K   D  +++  
Sbjct: 572  YRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQ 631

Query: 4052 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIK-----DTQDFIRDLEDPGI 4103
             ++N+ TL  E    +  V+    L  +      S + +IK     + Q  + +L+    
Sbjct: 632  QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFE 691

Query: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACG--EPDKPIVKKSIDELNSA 4161
            D   ++  QE+      +I  L++E+++      EL+ +    E ++ +    I E+ + 
Sbjct: 692  D--FLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRN- 748

Query: 4162 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQI 4221
               +    ++  D+L   ++  ++  D  ++VF                 T+ E +K+++
Sbjct: 749  ---IRLRLENCEDRLIRQIRTPLERDDLHESVFRI---------------TEQEKLKKEL 790

Query: 4222 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4281
            E LK           ++  + ++ E    +    S   T++  L  +    + +      
Sbjct: 791  ERLKD----------DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSST 840

Query: 4282 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341
               KL+   L L   Q A  E L  L  T+  L E++ V  D   IE  ++     +++V
Sbjct: 841  YIDKLKTVNLVLKNTQAA--EALVKLYETK--LCEEEAVIADKNNIENLISTLKQWRSEV 896

Query: 4342 LAHQSTVEAVN------KAGNDLIESSAGEEASNL---QNKLEVLNQRWQNVLEKTEQRK 4392
               +    A+       KA +D +  +  E   +    + K + L +RWQNV  + + R 
Sbjct: 897  DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956

Query: 4393 QQLDGALRQAKGFHGEIEDLQQWLTD---TERHLLASKPLGGLPETAKEQLNVHMEVCAA 4449
            + L+G  +  K +      L  W+     T+R +  ++P     +T   QLN    + + 
Sbjct: 957  RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENS--KTLATQLNQQKMLVSE 1014

Query: 4450 FEAKEE------------------------TYKSLMQKGQQ--MLARCPKSAETNIDQDI 4483
             E K+                         TY++++   Q+  +  R  +S+   I Q+ 
Sbjct: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074

Query: 4484 NNLKEKWESVET--------------KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4529
             +L+ ++ ++ T              +L E +  LEE     +E    LQ +++ +++  
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTL 1134

Query: 4530 QTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK 4589
            +    A +P            + K+ + E+++ +EQ+ E  +T   ++ F  K       
Sbjct: 1135 KDAEKAGKP---------PFSKQKISSEEISTKKEQLSEALQT---IQLFLAKHG----D 1178

Query: 4590 NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELE 4646
             +    ++  EK V+ L E              ++  +S+ ++ L+ES+ S D ++E
Sbjct: 1179 KMTDEERNELEKQVKTLQE-------------SYNLLFSESLKQLQESQTSGDVKVE 1222



 Score = 45.4 bits (106), Expect = 0.002
 Identities = 180/1047 (17%), Positives = 396/1047 (37%), Gaps = 200/1047 (19%)

Query: 1851 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1910
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344

Query: 1911 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1970
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385

Query: 1971 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2026
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438

Query: 2027 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2082
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490

Query: 2083 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2140
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550

Query: 2141 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2196
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608

Query: 2197 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2246
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665

Query: 2247 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2305
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725

Query: 2306 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2361
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766

Query: 2362 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2396
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826

Query: 2397 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2447
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886

Query: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932

Query: 2508 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2565
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991

Query: 2566 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2625
                 +   L TQ  Q ++L+ E   ++ + ++                       EQ +
Sbjct: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQK------------------YAEQYS 1033

Query: 2626 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA 2685
            A  + ++  T       D   ++ VK  + QS    +  +  DL  + ++ + +      
Sbjct: 1034 ATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL------ 1087

Query: 2686 MNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKA-ELSRQLEGILKSFKDV 2744
            M Q ++ A    + +++E+K ++  +          KE   KA EL + +  I K+ KD 
Sbjct: 1088 MTQYIKFAGDSLKRLEEEEKSLEEEK----------KEHVEKAKELQKWVSNISKTLKDA 1137

Query: 2745 EQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHK 2804
            E+             A    F +     +  + TKKE+      +S  L  ++  +  H 
Sbjct: 1138 EK-------------AGKPPFSKQKISSEE-ISTKKEQ------LSEALQTIQLFLAKHG 1177

Query: 2805 DFSKTLTAQSHMYE---KTIAEGENLL 2828
            D  K    + +  E   KT+ E  NLL
Sbjct: 1178 D--KMTDEERNELEKQVKTLQESYNLL 1202



 Score = 42.4 bits (98), Expect = 0.013
 Identities = 100/563 (17%), Positives = 217/563 (38%), Gaps = 89/563 (15%)

Query: 2655 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2711
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801

Query: 2712 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2771
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857

Query: 2772 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKT 2831
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++              
Sbjct: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFH------------- 904

Query: 2832 QGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNN 2891
                  AL+ +L   K   D   K  KER+       EKA +  E+ + +   ID    +
Sbjct: 905  ------ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD 958

Query: 2892 LEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2951
            LE I                KSL+   D +  + + +     +   + E   E     +K
Sbjct: 959  LEGIG---------------KSLKYYRDTYHPLDDWIQQVETTQRKIQENQPE----NSK 999

Query: 2952 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 3011
            +L         QL+ +K  +  +  K  +  E  K +++     K+          +  +
Sbjct: 1000 TL-------ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY---------ELQT 1043

Query: 3012 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3071
              Y  M+ +QQKS    +     A  + Q+ +     ++ T+ V L  + I     +L +
Sbjct: 1044 MTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM--DLRTRYTALVTLMTQYIKFAGDSLKR 1101

Query: 3072 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAE-----TLQKQKE 3126
              +E+ S  E K           +E   +  E    + +++   +DAE        KQK 
Sbjct: 1102 LEEEEKSLEEEK-----------KEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKI 1150

Query: 3127 TIKAFLKKLEALMASNDNANKTCKMMLA---TEETSPDLVGIKRDLEALSKQCNKLLDRA 3183
            + +    K E L      A +T ++ LA    + T  +   +++ ++ L +  N L   +
Sbjct: 1151 SSEEISTKKEQL----SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSES 1206

Query: 3184 --QAREEQVEGTIKRLEEFYSKL 3204
              Q +E Q  G +K +EE   K+
Sbjct: 1207 LKQLQESQTSGDVK-VEEKLDKV 1228



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294

Query: 4422 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4481
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351

Query: 4482 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4541
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394

Query: 4542 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4591
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453

Query: 4592 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4622
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513

Query: 4623 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4682
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572

Query: 4683 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4740
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622

Query: 4741 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4789
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682

Query: 4790 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4841
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742

Query: 4842 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4898
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802

Query: 4899 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4954
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862

Query: 4955 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5009
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922

Query: 5010 TYKRRAAD 5017
            TYK R  D
Sbjct: 923  TYKERDLD 930


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score = 2122 bits (5499), Expect = 0.0
 Identities = 1215/1987 (61%), Positives = 1414/1987 (71%), Gaps = 138/1987 (6%)

Query: 382  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 441
            RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL
Sbjct: 56   RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115

Query: 442  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 501
            RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG
Sbjct: 116  RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKGRILTTEQTKLMISG 175

Query: 502  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 561
            ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS
Sbjct: 176  ITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPS 235

Query: 562  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 621
            GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ
Sbjct: 236  GLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQ 295

Query: 622  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 681
            LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE
Sbjct: 296  LDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLE 355

Query: 682  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 741
            SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH
Sbjct: 356  SQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYH 415

Query: 742  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 801
            AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI
Sbjct: 416  AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHI 475

Query: 802  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 861
            KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK
Sbjct: 476  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 535

Query: 862  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 921
            STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK
Sbjct: 536  STIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAK 595

Query: 922  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 981
            WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY
Sbjct: 596  WKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHY 655

Query: 982  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 1041
            LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV
Sbjct: 656  LINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV 715

Query: 1042 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 1101
            NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE
Sbjct: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHE 775

Query: 1102 SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 1161
            SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY
Sbjct: 776  SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVY 835

Query: 1162 SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 1221
            SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE
Sbjct: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE 895

Query: 1222 VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1281
            VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR
Sbjct: 896  VDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 955

Query: 1282 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1341
            LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI
Sbjct: 956  LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEI 1015

Query: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401
            EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM
Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1075

Query: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1461
            DLRTRYTALVTLMTQYIKFAGDSLKRLEEEE    +E  EH   +  LQ+  + +   L+
Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQRQKATV---LE 1132

Query: 1462 DAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTL 1521
            +++  GK   S+ +    E+  +K ++ E L            K+ +   NEL KQ + +
Sbjct: 1133 NSKLTGK--ISELERMVAELKKQKSRVEEEL-----------PKVREAAENELRKQQRNV 1179

Query: 1522 QESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQ 1581
            ++        SL++++    +   + E + +   ++  + +L+ +  L  + E +    +
Sbjct: 1180 EDI-------SLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVE 1232

Query: 1582 EAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE 1641
            E  +  +   +L++    +  L+  ++    +L ++ +     ++E   K   E++ L  
Sbjct: 1233 ENLL--NFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKL 1290

Query: 1642 QKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS 1701
             K  E     + L  + + ++K+L +      K++ E  A  K  E   T  EN L    
Sbjct: 1291 IKQME-----KDLAFQKQVAEKQLKE------KQKIELEARRKITEIQYTCRENALPVCP 1339

Query: 1702 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT----Q 1757
                 S RA T  +Q                   E D+     L+  VD          Q
Sbjct: 1340 ITQATSCRAVTGLQQ-------------------EHDKQKAEELKQQVDELTAANRKAEQ 1380

Query: 1758 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVH 1817
            +     Y+    Q EK  S+ +A ++  +  +     +   L  E K++ +K        
Sbjct: 1381 DMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKG------- 1433

Query: 1818 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1877
            Y   L E  +++  T    EE  +  +D  + +   +  + ELE+L      +   + ++
Sbjct: 1434 YSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK---RNYQLELESLNHEKGKLQREVDRI 1490

Query: 1878 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCS-KRDGGKVDTSATHREV------QR 1930
             R  + +E  I H    +  +    + LE  + C  K D  K     +H ++      ++
Sbjct: 1491 TRAHAVAEKNIQHLNS-QIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549

Query: 1931 KLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIA 1990
            + +    R      K N     LK  V++     + +  ++  +QA         SE I 
Sbjct: 1550 ENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQA--------ESENIV 1601

Query: 1991 VDPKNLQRQLEETK----ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLD 2046
            ++ + +Q++ E  K      + Q+ S    + K  KT              + D Q+ + 
Sbjct: 1602 LEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKT--------------EQDFQRKIK 1647

Query: 2047 DIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTA 2106
             +    EDL+KS N  +E  Q    +++ +Q+   E+ +    + +S +E+ +       
Sbjct: 1648 CL---EEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRG------ 1698

Query: 2107 LQDIISKNIMLEQDIAGRQSSINAMNEKVKK-----FMETTDPSTASSLQAKMKDLSARF 2161
                       EQ +  +Q+ +  +N ++KK      ++T +           ++ S +F
Sbjct: 1699 -----------EQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKF 1747

Query: 2162 SEASHKHKETLAKMEELKTKVEL-FENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYM 2220
             +++ + ++ + K+ E K   E     +     +  +  ++A     +   ++ EL + +
Sbjct: 1748 KQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQL 1807

Query: 2221 QESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIK----- 2275
            Q+   E ++  +H+E  H    +     L + K  V      + ++ KE E  +      
Sbjct: 1808 QQ-YREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCE 1866

Query: 2276 -EKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2334
             +KK     C  + D F++ VK  +   + +++    + P+     L +  ++ + L+EK
Sbjct: 1867 IQKKSTAKDCTFKPD-FEMTVKECQHSGELSSRNTGHLHPT-PRSPLLRWTQEPQPLEEK 1924

Query: 2335 WSLKTPE 2341
            W  +  E
Sbjct: 1925 WQHRVVE 1931



 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 301/1713 (17%), Positives = 678/1713 (39%), Gaps = 246/1713 (14%)

Query: 1851 HWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS 1910
            +W+ + + +L+  E G+D +  + + L+  K+    +   +  L+   IS  ++    K 
Sbjct: 287  NWVDEMQVQLDRTEWGSD-LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLK- 344

Query: 1911 CSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1970
                         T+ E   +L+       S Y+K      N +  +D   ++   +   
Sbjct: 345  ------------LTYAEKLHRLE-------SQYAKLLNTSRNQERHLDTLHNFVSRATNE 385

Query: 1971 LAGLQACEATASKHLSEPIAVD----PKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2026
            L  L   E        E +A D      N+ R+ +    L  ++  ++  ++ +++ AE 
Sbjct: 386  LIWLNEKE-------EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQ 438

Query: 2027 LL----DARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDE 2082
            LL     AR ++   +  +Q     I+   + + + + E         T      +   E
Sbjct: 439  LLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN--------TAYFEFFNDAKE 490

Query: 2083 MLDWMGNVESSLKEQGQVPLNSTA--LQDIISKNIMLEQDIAGRQSSINAMNEKVKKFME 2140
              D++ N++ +++ +     +S+   L+D++ +++  ++++   +S+I  +  K K  ++
Sbjct: 491  ATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQ 550

Query: 2141 ----TTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2196
                 +D    +S+  K      +     +K  E +      + K ++      +     
Sbjct: 551  LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMV-- 608

Query: 2197 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLE--HKKHLEVL-----HSLLKEIS---S 2246
                     V  P K+  +L+  +++     L   H+ H+ +      H L+ EI    +
Sbjct: 609  ---PSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRA 665

Query: 2247 HGLPSDKALVL-EKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2305
              + S K ++  E    LS      ED +++ +E+       +   +  V   K + +E 
Sbjct: 666  SNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQEL 725

Query: 2306 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN----LISAVTT 2361
                               L+  ++ +++ S+    I +V N  + L N    LI  + T
Sbjct: 726  -------------------LKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766

Query: 2362 PAKAIAAVKSGGAVLNGE-------------GTATNT-EEFWANKGLTS----------- 2396
            P +     +S   +   E             GT TN  EEF++    +S           
Sbjct: 767  PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826

Query: 2397 IKKDMTDI---SHGYED----LGLLLKD-KIAELNTKLSKLQKAQEESS-AMMQWLQKMN 2447
            + ++M  +   S  Y D    + L+LK+ + AE   KL + +  +EE+  A    ++ + 
Sbjct: 827  VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886

Query: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507
             T  +W            +++V++ +     L+  + K + + D++ +  +E     +  
Sbjct: 887  STLKQW------------RSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFD-- 932

Query: 2508 RW-KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKE-LMVSVL 2565
             W K+   ++  +WQ ++    +R + LE    +L  ++     L  W+ + E     + 
Sbjct: 933  -WHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 991

Query: 2566 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2625
                 +   L TQ  Q ++L+ E   ++ + ++     +   S   +D  L+ +    + 
Sbjct: 992  ENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ-YSATVKDYELQTMTYRAMV 1050

Query: 2626 AVTQKWDSLTGQLSDRCDWIDQAIVK-STQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2684
               QK      ++    D I Q  +   T+Y +L+  ++  +     K +         +
Sbjct: 1051 DSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYI-----KFAGDSLKRLEEE 1105

Query: 2685 AMNQQLETAQ--KMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2742
             + +  ET++       +Q++K  +     L   +S L   E + AEL +Q   + +   
Sbjct: 1106 EIKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISEL---ERMVAELKKQKSRVEEELP 1162

Query: 2743 DVEQKAENHVQHLQ--------SACASSHQFQQMSRDFQAWLDTK---KEEQNKSHPISA 2791
             V + AEN ++  Q            +  + +Q  R+ +  +  K   + E  +   ++ 
Sbjct: 1163 KVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTI 1222

Query: 2792 KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE---GENLLLKTQGSEKAALQLQLNTIKT 2848
            + +   + ++++    +    ++    +T+ +    ++L L     +K  L  +L   + 
Sbjct: 1223 EAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRD 1282

Query: 2849 NWDTFNKQVKERENKL---KESLEKALKYKEQVE-TLWPWIDKCQNNLEEIKFCLDPAEG 2904
            N +   K +K+ E  L   K+  EK LK K+++E      I + Q    E    + P   
Sbjct: 1283 NEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQ 1342

Query: 2905 ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQL 2964
              S   +  LQ+E D+     E L    + L           T  N+   Q +  +T +L
Sbjct: 1343 ATSCRAVTGLQQEHDKQ--KAEELKQQVDEL-----------TAANRKAEQDMRELTYEL 1389

Query: 2965 HSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKS 3024
            ++ +    +  +K +  ++   E+   L+C K +L+  D    + YS           + 
Sbjct: 1390 NALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQ-AEKGYS-----------QQ 1437

Query: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTS-DVLLQVETIAQEHSTLSQQVDEKCSFLETK 3083
            L+ L  Q++     A++ + EASD K    +  L++E++  E   L ++VD       T+
Sbjct: 1438 LRELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDR-----ITR 1492

Query: 3084 LQGIGHFQNTIREMFSQFAEFDD--ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3141
               +   +  I+ + SQ   F D  EL+ +    R ++ L++Q E  K+  + L+ + A 
Sbjct: 1493 AHAVA--EKNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFE--KSHEQLLQNIKAE 1548

Query: 3142 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNK---LLDRAQAREEQV---EGTI- 3194
             +N +K  ++    E+++     +K+ +E L++Q N+   ++ R QA  E +   + TI 
Sbjct: 1549 KENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQ 1608

Query: 3195 KRLEEFYSKLKEFSILLQKAEEH--------EESQGPVGMETETINQQLNMFKVFQKEEI 3246
            +R E    +   F   L+   EH        ++ Q  +    E + +  N+   F++   
Sbjct: 1609 QRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQ--- 1665

Query: 3247 EPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALL 3306
               +  QQ++      +IQ+  K    + L  +L+      +   +KV  + AQ+QE   
Sbjct: 1666 ---KCDQQNI------IIQNTKK--EVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNN 1714

Query: 3307 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3366
               + QD L         T   +   +  S +FK  ++  + +K +++L++ +  T   I
Sbjct: 1715 RLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFK--QSAEEFRKKMEKLMESKVITENDI 1772

Query: 3367 KREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEP 3426
               G ++   +   +  +  +   L ++  + L  + +    Q++    +    ++  + 
Sbjct: 1773 --SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQK 1830

Query: 3427 LNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK 3459
            L + L   ++ + N +       K+++QI +H+
Sbjct: 1831 LEDELIAQKREVENLK------QKMDQQIKEHE 1857



 Score = 80.9 bits (198), Expect = 3e-14
 Identities = 262/1418 (18%), Positives = 538/1418 (37%), Gaps = 200/1418 (14%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEES 3220
            D+  +++++    +   +LL  A+ REEQ E        + S+++   + L+  E+    
Sbjct: 707  DITQLEKEVNVCKQYYQELLKSAE-REEQEESVYNL---YISEVRNIRLRLENCEDRLIR 762

Query: 3221 QGPVGMETETINQQLNMFKVFQKE----EIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276
            Q    +E + +++  ++F++ ++E    E+E L+     +    +     AA S+S   L
Sbjct: 763  QIRTPLERDDLHE--SVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTL 820

Query: 3277 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ--DALESLLSWMVDTEELVANQKP 3334
              +L+ V      +    +    +L+   L     Q  +AL  L    +  EE V   K 
Sbjct: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKN 880

Query: 3335 PS----AEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3390
                  +  K  ++++ E++ +   L+D     + I  E  K     +  D     ++  
Sbjct: 881  NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD-LDFDWHKEKAD 939

Query: 3391 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3450
             L  RW+ +  + + R R LEGI    + + +T  PL++W+  +E      +    + SK
Sbjct: 940  QLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSK 999

Query: 3451 -LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3509
             L  Q+ Q K L  +I      + +     +      S   KD     + +  +  ++ Q
Sbjct: 1000 TLATQLNQQKMLVSEIEMKQSKMDECQKYAEQY----SATVKDYELQTMTYRAM--VDSQ 1053

Query: 3510 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3569
            +KS  +   +Q    +A +  ++ ++    L   +  L  L  Q     G       L+ 
Sbjct: 1054 QKSPVKRRRMQS---SADLIIQEFMD----LRTRYTALVTLMTQYIKFAG-----DSLKR 1101

Query: 3570 LQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3629
            L+E+ + R               K+T+  E     D L+  KA   + +KL+  +++   
Sbjct: 1102 LEEEEIKR--------------CKETS--EHGAYSDLLQRQKATVLENSKLTGKISELER 1145

Query: 3630 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKAL 3689
               +L ++     EEL    +  E EL   +  V   E+ S  ++R +   K+ +     
Sbjct: 1146 MVAELKKQKSRVEEELPKVREAAENELRKQQRNV---EDISLQKIRAESEAKQYRRELET 1202

Query: 3690 LDSLNEVSSALLELVPWRAREGLEKMVAED----NERYRLVSDTITQKVEEIDAAILRSQ 3745
            +    E +   LE V     E   K  A +    N R +L  +T T++  E         
Sbjct: 1203 IVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLE--------- 1253

Query: 3746 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKS 3805
                            ++K +SL D           L+ QK   ME LR K         
Sbjct: 1254 -------------DHLKRKDLSLND-----------LEQQKNKLMEELRRK--------- 1280

Query: 3806 GHKIMTACSEEEKQSMKKKLDKVLKNYDTIC--QINSERYLQLERAQSLVNQFWETYEEL 3863
                    +EEE   + K+++K L     +   Q+  ++ ++LE  + +    +   E  
Sbjct: 1281 ------RDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENA 1334

Query: 3864 WPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHIDKMNKTGPQLLELS 3922
             P    TQ+  S      L+ E  +Q+ EE  +Q+ EL A ++     M +   +L  L 
Sbjct: 1335 LPVCPITQA-TSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQ 1393

Query: 3923 PGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 3982
              +  S ++  +  D L  +    ++   + L+        +  ++ ++   L +   + 
Sbjct: 1394 LEKTSSEEKARLLKDKL-DETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKA 1452

Query: 3983 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042
             +    +++++KIK      +N  +++E L   +E  K + E         D+   A AV
Sbjct: 1453 EEAMQEASDLKKIK------RNYQLELESLN--HEKGKLQRE--------VDRITRAHAV 1496

Query: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDVME-----LAEKFWCDHMSLIVTI---KDTQDF 4094
             +K   +  +   IH+  +E+E + L + +     L E+F   H  L+  I   K+  D 
Sbjct: 1497 AEK--NIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDK 1554

Query: 4095 IRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4154
            I+ L +       +++  E AE ++++++ L  + +    L  + I A  E +  + K++
Sbjct: 1555 IQRLNEE------LEKSNECAEMLKQKVEELTRQ-NNETKLMMQRIQAESE-NIVLEKQT 1606

Query: 4155 IDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL 4214
            I +   A       +KD++    E +    + +   Q               +  +  DL
Sbjct: 1607 IQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQ-------------RKIKCLEEDL 1653

Query: 4215 ETVKQQIEELKQ--FKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIW 4272
               +  + E KQ   +     Q  + E  N  AEL   K  +   +  VQ        + 
Sbjct: 1654 AKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQ--------LQ 1705

Query: 4273 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4332
             +  + + NR  K++  L         L  +   +TH + +L +++       A E    
Sbjct: 1706 QAQVQELNNRLKKVQDEL--------HLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKK 1757

Query: 4333 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4392
               ++++ V+           +G  L   S  +E S  Q   ++     + +  + +Q +
Sbjct: 1758 MEKLMESKVITENDI------SGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYR 1811

Query: 4393 QQLDGALRQAKGFHGEIEDLQQWLTDTERHL--LASKPLGGLPETAKEQLNVHMEVCAAF 4450
            +Q+          + + + L+  L   +R +  L  K    + E   + + +  E+    
Sbjct: 1812 EQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKS 1871

Query: 4451 EAKEETYK--------------SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
             AK+ T+K               L  +    L   P+S      Q+   L+EKW+    +
Sbjct: 1872 TAKDCTFKPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVE 1931

Query: 4497 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4534
               ++ + +      +E   S Q +  + +Q    L +
Sbjct: 1932 QIPKEVQFQPP-GAPLEKEKSQQCYSEYFSQTSTELQI 1968



 Score = 77.8 bits (190), Expect = 3e-13
 Identities = 229/1247 (18%), Positives = 500/1247 (40%), Gaps = 199/1247 (15%)

Query: 2655 YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ---QLETAQKMKQEIQQEKKQIKVAQ 2711
            Y S +R++  +L + +++L   +      D +++   ++   +K+K+E+++ K  +    
Sbjct: 742  YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 801

Query: 2712 ALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRD 2771
              CE+  +          L  +L  +L++   V   +  ++  L++     +   + ++ 
Sbjct: 802  NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTV----NLVLKNTQA 857

Query: 2772 FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYE---------KTIA 2822
             +A +   + +  +   + A  + +E+LI   K +   +  +  ++          K I+
Sbjct: 858  AEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS 917

Query: 2823 EGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK-YKEQVETL 2881
            +      K +  +    + + + +   W   + Q+  R   L E + K+LK Y++    L
Sbjct: 918  DEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDL-EGIGKSLKYYRDTYHPL 976

Query: 2882 WPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEI 2941
              WI + +    +I+        EN     K+L  +++Q              L+S  E+
Sbjct: 977  DDWIQQVETTQRKIQ--------ENQPENSKTLATQLNQQ-----------KMLVSEIEM 1017

Query: 2942 DKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK-FKEFQEVSKESKRQLQCAKEQLD 3000
             K+   DE +   ++          K + L+ MT +   + Q+ S   +R++Q + + L 
Sbjct: 1018 -KQSKMDECQKYAEQYSATV-----KDYELQTMTYRAMVDSQQKSPVKRRRMQSSAD-LI 1070

Query: 3001 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLV---VEASDSKGTSDVLL 3057
            I + +  +      +T++       Q +K   D  KRL ++ +    E S+    SD+L 
Sbjct: 1071 IQEFMDLRTRYTALVTLM------TQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQ 1124

Query: 3058 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3117
            + +    E+S L+ ++ E               +  + E+  Q +  ++EL  +     +
Sbjct: 1125 RQKATVLENSKLTGKISE--------------LERMVAELKKQKSRVEEELPKVREAAEN 1170

Query: 3118 AETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKR-DLEALSKQC 3176
             E  ++Q+      L+K+ A   +     +   ++   E    +L  +++  +EA +K+ 
Sbjct: 1171 -ELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRA 1229

Query: 3177 NKLLDRAQAREEQVEGTI-KRLEEFYSKLKEFS---ILLQKAEEHEESQGPVGMETETIN 3232
                +    R +  E T  +R  E + K K+ S   +  QK +  EE +     E E + 
Sbjct: 1230 AVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLK 1289

Query: 3233 --QQLNMFKVFQKEEIEPLQGKQQDV-----------------NWLGQGLIQSAAKSTST 3273
              +Q+     FQK+  E    ++Q +                 N L    I  A    + 
Sbjct: 1290 LIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCRAV 1349

Query: 3274 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3333
             GL+ + D          K+ A+   Q  + L    R  +     L++ ++  +L   +K
Sbjct: 1350 TGLQQEHD----------KQKAEELKQQVDELTAANRKAEQDMRELTYELNALQL---EK 1396

Query: 3334 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3393
              S E         + +LL+  LD+  +T+  +K E E+     + A+K    +QL  L 
Sbjct: 1397 TSSEE---------KARLLKDKLDETNNTLRCLKLELER----KDQAEK-GYSQQLRELG 1442

Query: 3394 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3453
             +      KAE   ++   +  + + +   LE LN      EK        G    +++ 
Sbjct: 1443 RQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNH-----EK--------GKLQREVDR 1489

Query: 3454 QIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ-EKS 3512
                H   E +I + N  +H            S R++K++ + ++   +  +++ Q EKS
Sbjct: 1490 ITRAHAVAEKNIQHLNSQIH------------SFRDEKELERLQICQRKSDHLKEQFEKS 1537

Query: 3513 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE 3572
            H   +LLQ     A+    D+++ +N   E  ++ +++  Q    E L +Q +E +++ +
Sbjct: 1538 H--EQLLQN--IKAEKENNDKIQRLNEELEKSNECAEMLKQ--KVEELTRQNNETKLMMQ 1591

Query: 3573 DILLRKQNV---DQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDV---A 3625
             I    +N+    Q +    E LK Q  G      +D+L +        TK   D     
Sbjct: 1592 RIQAESENIVLEKQTIQQRCEALKIQADG-----FKDQLRSTNEHLHKQTKTEQDFQRKI 1646

Query: 3626 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQAQMRPKELKKEAK 3684
            K LE+ L  ++ L S  ++ C     + ++    E + L  E  AS+ + R  E K + +
Sbjct: 1647 KCLEEDLAKSQNLVSEFKQKCD-QQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ 1705

Query: 3685 NNKA--LLDSLNEVSSAL-LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3741
              +   L + L +V   L L+ +  +       +  E++ +++  ++   +K+E++    
Sbjct: 1706 QAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKL---- 1761

Query: 3742 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ--LQVQKTFTMEILRHKDII 3799
                        E   ITE +   + L  + L+Q+ + AQ   ++ +T   E+ R     
Sbjct: 1762 -----------MESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQY 1810

Query: 3800 DDLVKSGHKIMT-------------ACSEEEKQSMKKKLDKVLKNYD 3833
             + ++ G  +                  + E +++K+K+D+ +K ++
Sbjct: 1811 REQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHE 1857



 Score = 72.8 bits (177), Expect = 9e-12
 Identities = 273/1451 (18%), Positives = 559/1451 (38%), Gaps = 183/1451 (12%)

Query: 3515 RSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3574
            +S LL Q L   +I  +   +L+NW++E+  +L +           W   S+L  + E  
Sbjct: 264  KSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE---------W--GSDLPSV-ESH 311

Query: 3575 LLRKQNVDQALLNGLELLKQTTGDEV-------LIIQDKLEAIKARYKDITKLSTDVAKT 3627
            L   +NV +A+      LK+    E+       L   +KL  ++++Y  +   S +  + 
Sbjct: 312  LENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERH 371

Query: 3628 LEQALQLARRLHSTHEELCTWLDKVEVELLSYE-----TQVLKGEEASQAQMRPKELKKE 3682
            L+       R  +T+E +  WL++ E E ++Y+     T + + ++     MR  EL ++
Sbjct: 372  LDTLHNFVSR--ATNELI--WLNEKEEEEVAYDWSERNTNIARKKDYHAELMR--ELDQK 425

Query: 3683 AKNNKALLD----SLNEVSSALLELVPWRAR------------EGLEKMVAEDNERYRLV 3726
             +N K++ +     L E   A L +  +RA             + +E+ + E+   +   
Sbjct: 426  EENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485

Query: 3727 SDT--ITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQV 3784
            +D    T  +  +  AI R    D++  + +  + +  ++ M   +  L+   T A L +
Sbjct: 486  NDAKEATDYLRNLKDAIQRKYSCDRS--SSIHKLEDLVQESMEEKEELLQYKSTIANL-M 542

Query: 3785 QKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKN------YDTICQ 3837
             K  T+  L+ ++  D  +K+   I   C   + +    K D+ VL N      +  I  
Sbjct: 543  GKAKTIIQLKPRN-SDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISP 601

Query: 3838 INSERYLQL---------ERAQSLVNQFWETYEE-LWPWLTETQSIISQLPAPALEYETL 3887
              +E  +           + A  L N+  + Y+  L  W     ++ S +    L  E  
Sbjct: 602  TGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEID 661

Query: 3888 RQQQEEHRQLRELI-AEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVAADTLY 3940
            R +      ++ ++  EH+  +  +       LE S       G   +  EK V    + 
Sbjct: 662  RIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV---NVC 718

Query: 3941 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE--- 3997
             Q  +++ K A   ++  S    +  ++  I   LE   +RL +      E + + E   
Sbjct: 719  KQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVF 778

Query: 3998 QISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIH 4057
            +I+E + +  ++E+L+    T+  + EE  +++  +    S   ++ +L+ ++     ++
Sbjct: 779  RITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASS---SVPTLRSELNVVLQNMNQVY 835

Query: 4058 TLVEEREAKLLDV-------------MELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4104
            ++      KL  V             ++L E   C+  ++I    + ++ I         
Sbjct: 836  SMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI--------- 886

Query: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI--VKKSIDELNSAW 4162
             S +KQ +   +  R+    L++EL     +  E+     E D      K+  D+L   W
Sbjct: 887  -STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERW 945

Query: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW---VDIAGGKLASMSPIGTDLETVKQ 4219
             +++    +R+  LE   ++   Y+D    + DW   V+    K+    P   + +T+  
Sbjct: 946  QNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQP--ENSKTLAT 1003

Query: 4220 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERI 4279
            Q+ + K   SE   +Q +M+     AE     V +       +   M  + + DS ++  
Sbjct: 1004 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKD------YELQTMTYRAMVDSQQKSP 1057

Query: 4280 INRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP-KAIEIELAK----- 4333
            + R+     A L + +F        A +T    L+++     GD  K +E E  K     
Sbjct: 1058 VKRRRMQSSADLIIQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEIKRCKET 1113

Query: 4334 -HHVLQNDVLAHQ-STVEAVNKAGNDLIE-----SSAGEEASNLQNKLEVLNQRWQNVLE 4386
              H   +D+L  Q +TV   +K    + E     +   ++ S ++ +L  + +  +N L 
Sbjct: 1114 SEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELR 1173

Query: 4387 KTEQRKQQLD----GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4442
            K ++  + +      A  +AK +  E+E + +     ER L               QL +
Sbjct: 1174 KQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL-----------ERVRQLTI 1222

Query: 4443 HMEV-CAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4501
              E   AA E     +++ +++      R  +      D  +N+L+++   +  +L  ++
Sbjct: 1223 EAEAKRAAVEENLLNFRNQLEE-NTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKR 1281

Query: 4502 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4561
               EE L L  +     +D       AE+ L    +  L     + +I ++    N +  
Sbjct: 1282 DNEEELLKLIKQME---KDLAFQKQVAEKQLKEKQKIELEARRKITEI-QYTCRENALPV 1337

Query: 4562 HREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAK 4621
                     +  T L+    KQ    +K  +  + +   K  Q + E    L+  +    
Sbjct: 1338 CPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEKT 1397

Query: 4622 QFHEAWSKLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNR 4680
               E    L + L+E+  +L   +LE+       K    Q +E  + L        TT +
Sbjct: 1398 SSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN------QTTGK 1451

Query: 4681 TGRSLKEKTSL----ADDNLKLDDMLSE---LRDKWDTICGKSVERQNKLEEALLFSGQF 4733
               +++E + L     +  L+L+ +  E   L+ + D I       +  ++        F
Sbjct: 1452 AEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSF 1511

Query: 4734 TDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNL------IDNHKAFQKELGKRTSSVQA 4787
             D  +     + + +    ++Q       L+ N+       D  +   +EL K     + 
Sbjct: 1512 RDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEM 1571

Query: 4788 LKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4847
            LK+   EL   + +     K+ MQ +    E +     + Q R EA   QA+ F   + +
Sbjct: 1572 LKQKVEELTRQNNE----TKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRS 1627

Query: 4848 LLEWLAEAEQT 4858
              E L +  +T
Sbjct: 1628 TNEHLHKQTKT 1638



 Score = 53.9 bits (128), Expect = 4e-06
 Identities = 166/831 (19%), Positives = 325/831 (39%), Gaps = 149/831 (17%)

Query: 4148 KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASM 4207
            KP++K S+ + N   + +N  +          +Q  + + D +Q   D  +  G  L S+
Sbjct: 260  KPLLKSSLLDQNLTEEEINMKF----------VQDLLNWVDEMQVQLDRTEW-GSDLPSV 308

Query: 4208 SPIGTDLETVKQQIEELKQFKSEAYQQQIEM------------ERLNHQ-AELLLKKVTE 4254
                 + + V + IEE +    EA   +I+M             RL  Q A+LL     +
Sbjct: 309  ESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQ 368

Query: 4255 ESDKHTVQDPLMEL--KLIW-DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE 4311
            E    T+ + +     +LIW +  EE  +          +A  +  HA  EL+  L   E
Sbjct: 369  ERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA--ELMRELDQKE 426

Query: 4312 GLL------SEQKPVGGDPKAIEIEL------------------AKHHVLQNDVLAH--Q 4345
              +      +EQ  +   P  + IE                    + H+ +N        
Sbjct: 427  ENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFN 486

Query: 4346 STVEAVNKAGN--DLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAK 4403
               EA +   N  D I+     + S+  +KLE L Q      E+  Q K  +   + +AK
Sbjct: 487  DAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAK 546

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM--EVCAAFEAKEETYKSLM 4461
                    +Q    +++  L  S P+  + +  + ++ ++   E   A  +    +K + 
Sbjct: 547  TI------IQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVIS 600

Query: 4462 QKGQQMLA-----RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHN 4516
              G + +        P   +  +D   N +++++++V T  +E    ++  +        
Sbjct: 601  PTGNEAMVPSVCFTVPPPNKEAVDL-ANRIEQQYQNVLTLWHESHINMKSVV-------- 651

Query: 4517 SLQDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSH 4562
            S    IN + +   + NVAS  +++               +  L    E +VF+    + 
Sbjct: 652  SWHYLINEIDRIRAS-NVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQ 710

Query: 4563 REQIIELDKTGTH--LKYFSQKQDVVLIKNLLIS----VQSRWEKVVQRLVERGRSLDDA 4616
             E+ + + K      LK   +++    + NL IS    ++ R E    RL+ + R+    
Sbjct: 711  LEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT---- 766

Query: 4617 RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYD 4676
                   HE+  ++ E     ++ L  ELE   D   + T   + +EF     A  SV  
Sbjct: 767  PLERDDLHESVFRITE-----QEKLKKELERLKDD--LGTITNKCEEFFSQAAASSSV-- 817

Query: 4677 TTNRTGRSLKEKTSLADDNL-KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTD 4735
                   +L+ + ++   N+ ++  M S   DK  T+   ++  +N            T 
Sbjct: 818  ------PTLRSELNVVLQNMNQVYSMSSTYIDKLKTV---NLVLKN------------TQ 856

Query: 4736 ALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQAL------- 4788
            A +AL+  LY  E +L E++ V  D + + NLI   K ++ E+ ++     AL       
Sbjct: 857  AAEALVK-LY--ETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA 913

Query: 4789 KRSARELIEGSRD---DSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVV 4845
            K  + E+ +  ++   D  W K +  +L  RW+ V     ++   LE   +  + +    
Sbjct: 914  KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY 973

Query: 4846 HALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNK 4895
            H L +W+ + E T R      P++   L T ++Q K  + ++E K++++++
Sbjct: 974  HPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024



 Score = 40.8 bits (94), Expect = 0.037
 Identities = 46/200 (23%), Positives = 86/200 (43%), Gaps = 16/200 (8%)

Query: 4737 LQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4795
            +Q L++W+  ++ QL  D+   G D+  V + ++NHK   + + +  SS++  K S  ++
Sbjct: 282  VQDLLNWVDEMQVQL--DRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM 339

Query: 4796 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4855
                   ++ +K+   E   R E+  A  ++     E  L     F S     L WL E 
Sbjct: 340  -------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 392

Query: 4856 EQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4915
            E+    +     + +  R   D H E M++L++K   +     + + +L   HP  +T  
Sbjct: 393  EEEEVAYDWSERNTNIARKK-DYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLT-- 449

Query: 4916 KHWITIIRARFEEVLAWAKQ 4935
               I   RA  +   +W  Q
Sbjct: 450  ---IEAYRAAMQTQWSWILQ 466



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 147/728 (20%), Positives = 270/728 (37%), Gaps = 111/728 (15%)

Query: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421
            S+G E ++LQ  L+++  R      K   +   LD  L + +     ++DL  W+ + + 
Sbjct: 242  SSGVEPNSLQT-LKLMQIR------KPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQV 294

Query: 4422 HLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4481
             L  ++    LP + +  L  H  V  A E  E + K       QM A    +    +  
Sbjct: 295  QLDRTEWGSDLP-SVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKL-- 351

Query: 4482 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4541
                   + ES   KL       E  L+    F +   + + WL + E+           
Sbjct: 352  ------HRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE----------- 394

Query: 4542 LDTVLFQIDEHKV-FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKN---------L 4591
             + V +   E     A + + H E + ELD+   ++K   +  + +L++N          
Sbjct: 395  -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 453

Query: 4592 LISVQSRWEKVVQ--RLVERG---------------------RSLDDA--RK----RAKQ 4622
              ++Q++W  ++Q  + VE+                      R+L DA  RK    R+  
Sbjct: 454  RAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSS 513

Query: 4623 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4682
             H+    + E +EE E+ L  +  IAN   K KT + Q K        K S+        
Sbjct: 514  IHKLEDLVQESMEEKEELLQYKSTIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDY 572

Query: 4683 RSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT--DALQAL 4740
            R + E T   DD   L +  +  R KW  I            EA++ S  FT     +  
Sbjct: 573  RQI-EITIYKDDECVLAN--NSHRAKWKVISPTG-------NEAMVPSVCFTVPPPNKEA 622

Query: 4741 IDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALK---------- 4789
            +D   R+E Q      +  +  + M  + +      E+ + R S+V ++K          
Sbjct: 623  VDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQV 682

Query: 4790 -RSARELIEGSRDDSSWVKV-QMQELSTRWETVCALSISKQTRLEAALRQAEE------F 4841
              + +   E   +DS   +V    +++   + V       Q  L++A R+ +E      +
Sbjct: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLY 742

Query: 4842 HSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT---LIDQHKEFMKKLEEKRAELNKATT 4898
             S V  +   L   E  L      P + D L      I + ++  K+LE  + +L   T 
Sbjct: 743  ISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITN 802

Query: 4899 MGDTVLA-ICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLAS---ALAGLIAKQELL 4954
              +   +      S+ T++  + ++     +V + +  +  +L +    L    A + L+
Sbjct: 803  KCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALV 862

Query: 4955 EALLAWLQWAETTLTDKDK-----EVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTK 5009
            +     L   E  + DK+        + Q   EV           +E+ + +   D++ K
Sbjct: 863  KLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922

Query: 5010 TYKRRAAD 5017
            TYK R  D
Sbjct: 923  TYKERDLD 930


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  861 bits (2224), Expect = 0.0
 Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 518  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 578  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 638  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 698  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 758  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 818  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 878  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997

Query: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 998  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117

Query: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1296

Query: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356

Query: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1413

Query: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1414 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1456

Query: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1457 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1564

Query: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1565 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1620

Query: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1670

Query: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1671 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1725

Query: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1726 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969
            S S++   +++  A      R+L     R R+L  +        ++  D  +   +A   
Sbjct: 1780 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1834

Query: 1970 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2024
            L   L A  EAT  K  +E IA+  K  +    R+L E +A Q +   +Q A  K     
Sbjct: 1835 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1888

Query: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
                D    L   +      L+   G  ED  +   +  E++       L+++   ++  
Sbjct: 1889 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1938

Query: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
               G  E  L E G++  N+   +D +      E + A RQ  + A  E+ ++  E    
Sbjct: 1939 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1987

Query: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204
                  +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   
Sbjct: 1988 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040

Query: 2205 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2258
            E         E      + Q  QE      + +  L+ L    +        +++A V +
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2099

Query: 2259 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2318
                 ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159

Query: 2319 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2377
            +    + +E  KK  E+   +  ++++     ++   L    T   K +  +      L 
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2213

Query: 2378 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2432
             E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2266

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2489
            QEE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   L
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 2490 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2548
            K +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+E
Sbjct: 2326 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2369

Query: 2549 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2608
            A+ ++ L                   ++ + +++++ + E +  + + E+     +    
Sbjct: 2370 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 2609 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2668
              GE      +  ++   + Q  +    Q     + + +AI +  + +  L+        
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2464

Query: 2669 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2724
             + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E
Sbjct: 2465 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523

Query: 2725 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2784
              KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ 
Sbjct: 2524 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2581

Query: 2785 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
            +   + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633



 Score =  566 bits (1458), Expect = e-160
 Identities = 272/454 (59%), Positives = 363/454 (79%), Gaps = 1/454 (0%)

Query: 27  ERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKG 86
           E  KDERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKG
Sbjct: 34  EGKKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKG 93

Query: 87  RMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTG 146
           RMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G
Sbjct: 94  RMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSG 153

Query: 147 ESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQ 206
           +SEDM+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V  Q
Sbjct: 154 QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 213

Query: 207 SNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIG 265
           +NL NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP+  +G+ 
Sbjct: 214 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 273

Query: 266 ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKE 325
           AN+++++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE E+P KE
Sbjct: 274 ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKE 333

Query: 326 TEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEM 385
            +K++ K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR E ERLE 
Sbjct: 334 ADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLEC 393

Query: 386 LQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHV 445
           LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++R   
Sbjct: 394 LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 453

Query: 446 IDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 479
            DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 454 NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 487



 Score =  111 bits (277), Expect = 2e-23
 Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)

Query: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 959  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1018

Query: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1078

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 1079 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1130

Query: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 1131 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187

Query: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2907
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247

Query: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1280

Query: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1339

Query: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3086
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398

Query: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 1399 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450

Query: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1499

Query: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264
            +         +  +ESQ     E E  ++         K E E  + KQ+ +  L +  +
Sbjct: 1500 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1543

Query: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
            Q+                     + L +   +RA Q+Q AL                   
Sbjct: 1544 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1567

Query: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
                   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 1568 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1623

Query: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
            +   +  L   RW+   N+A     Q E    VAQQ     + L +     EK+    E 
Sbjct: 1624 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1671

Query: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3557
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791

Query: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1843

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 1844 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1896

Query: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 1897 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1944

Query: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 1945 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1997

Query: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3847
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ E 
Sbjct: 1998 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051

Query: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907
            +A +   Q  E  +EL   L + QS++ QL   A   E  R+  EE  + R         
Sbjct: 2052 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2106

Query: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 3962
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166

Query: 3963 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4003
             + H K           ++Q L +L  ++ E   Q   +  E++++K + +E        
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226

Query: 4004 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4058
                 +V V ME+L  L   ++     +I R    DKD + + +Q++ ++M  + E    
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2282

Query: 4059 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
            L V  +EA  L   +LAE+      +L    +K+    +++      +  +++QQ+E A+
Sbjct: 2283 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340

Query: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176
               E+   LQE+ +       ++     E  +   +    E     +   +A + ++ ++
Sbjct: 2341 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2389

Query: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4236
             E  +A  + ++  Q      +  G KL        +  T+ Q +E             I
Sbjct: 2390 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2436

Query: 4237 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4295
            + ++ +H AE L + + E E +K  +Q    E KL+    EE    +Q +L     AL Q
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493

Query: 4296 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4351
                     ++L+  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E  
Sbjct: 2494 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
             +    L+ S   EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +
Sbjct: 2545 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2596

Query: 4412 LQQWLTDTERHLLA 4425
              Q L +  R  LA
Sbjct: 2597 QLQLLEEQHRAALA 2610



 Score = 94.0 bits (232), Expect = 4e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 950  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1003

Query: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 1004 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1055

Query: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 1056 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1115

Query: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 1116 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1175

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 1176 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1233

Query: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 1234 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1352

Query: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 1353 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1396

Query: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1450

Query: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510

Query: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 1511 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1559

Query: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 1560 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1595

Query: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 1596 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1637

Query: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1696

Query: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 1697 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1750

Query: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1805

Query: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 1806 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861

Query: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 1862 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920

Query: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980

Query: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040

Query: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2091

Query: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2151

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 2152 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205

Query: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 2206 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2261

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 2262 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2310

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370

Query: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 2371 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427

Query: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2485

Query: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 2486 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542

Query: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2586

Query: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 2587 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2623



 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 1126 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1180

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 1181 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297

Query: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 1298 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1343

Query: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403

Query: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1455

Query: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 1456 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1508

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 1509 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1558

Query: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 1559 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 1614 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1666

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726

Query: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840

Query: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 1841 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1889

Query: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 1890 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1940

Query: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 1941 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996

Query: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 1997 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2041

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 2042 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 2095 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2257

Query: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2309

Query: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 2310 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2364

Query: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 2365 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2417

Query: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 2418 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469

Query: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510



 Score = 78.6 bits (192), Expect = 2e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 512  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 564

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 565  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 620

Query: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 621  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 674

Query: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 675  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 713

Query: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 714  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 762

Query: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 763  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 810

Query: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 811  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 864

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 865  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 919

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 920  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 963

Query: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 964  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1012

Query: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1072

Query: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 1073 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1128

Query: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 1129 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1186

Query: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246

Query: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306

Query: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366

Query: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425

Query: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 1426 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1476

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1535

Query: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 1536 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593

Query: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1633

Query: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 1694 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749

Query: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809

Query: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 1810 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1863

Query: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 1864 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922

Query: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982

Query: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042

Query: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 2043 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095

Query: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2150

Query: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 2151 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2209

Query: 5067 QQVWLLALERRRKLNDALDRLEELR 5091
            Q++   A E  R+ +   + L  +R
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVR 2234



 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1069

Query: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1125

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185

Query: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 1186 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1244

Query: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 1245 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1285

Query: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 1286 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1345

Query: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1405

Query: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 1406 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1461

Query: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 1462 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1517

Query: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 1636 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691

Query: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750

Query: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1803

Query: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 1804 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1853

Query: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 1854 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1892

Query: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1951

Query: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223

Query: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2284 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340

Query: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400

Query: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460

Query: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520

Query: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 2521 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577

Query: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2637

Query: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501
            ++ +        +++  ++ LQ   +  A+
Sbjct: 2638 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2667



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)

Query: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 364  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 423

Query: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 424  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 483

Query: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 484  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 535

Query: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 536  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 595

Query: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4861
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+    
Sbjct: 596  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 640

Query: 4862 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909
                 D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 641  GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 688



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 4457 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4507


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  861 bits (2224), Expect = 0.0
 Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 522  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 582  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 641

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 642  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 701

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 702  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 761

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 762  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 822  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 881

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 882  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 941

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 942  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1001

Query: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1002 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1062 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121

Query: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1181

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241

Query: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1300

Query: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1301 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1360

Query: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1361 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1417

Query: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1418 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1460

Query: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1461 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510

Query: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1568

Query: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1569 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1624

Query: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1625 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1674

Query: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1675 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1729

Query: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1730 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783

Query: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969
            S S++   +++  A      R+L     R R+L  +        ++  D  +   +A   
Sbjct: 1784 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1838

Query: 1970 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2024
            L   L A  EAT  K  +E IA+  K  +    R+L E +A Q +   +Q A  K     
Sbjct: 1839 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1892

Query: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
                D    L   +      L+   G  ED  +   +  E++       L+++   ++  
Sbjct: 1893 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1942

Query: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
               G  E  L E G++  N+   +D +      E + A RQ  + A  E+ ++  E    
Sbjct: 1943 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1991

Query: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204
                  +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   
Sbjct: 1992 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044

Query: 2205 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2258
            E         E      + Q  QE      + +  L+ L    +        +++A V +
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2103

Query: 2259 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2318
                 ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   
Sbjct: 2104 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2163

Query: 2319 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2377
            +    + +E  KK  E+   +  ++++     ++   L    T   K +  +      L 
Sbjct: 2164 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2217

Query: 2378 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2432
             E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  
Sbjct: 2218 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2270

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2489
            QEE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   L
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329

Query: 2490 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2548
            K +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+E
Sbjct: 2330 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2373

Query: 2549 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2608
            A+ ++ L                   ++ + +++++ + E +  + + E+     +    
Sbjct: 2374 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2415

Query: 2609 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2668
              GE      +  ++   + Q  +    Q     + + +AI +  + +  L+        
Sbjct: 2416 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2468

Query: 2669 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2724
             + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E
Sbjct: 2469 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2527

Query: 2725 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2784
              KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ 
Sbjct: 2528 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2585

Query: 2785 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
            +   + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2586 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2637



 Score =  563 bits (1452), Expect = e-159
 Identities = 270/450 (60%), Positives = 361/450 (80%), Gaps = 1/450 (0%)

Query: 31  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 90
           DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 42  DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 101

Query: 91  HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 150
           H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 102 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 161

Query: 151 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 210
           M+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V  Q+NL 
Sbjct: 162 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 221

Query: 211 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 269
           NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP+  +G+ AN++
Sbjct: 222 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 281

Query: 270 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 329
           +++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE E+P KE +K+
Sbjct: 282 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 341

Query: 330 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 389
           + K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 342 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 401

Query: 390 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 449
             ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++R    DVQ
Sbjct: 402 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 461

Query: 450 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 479
            L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 462 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 491



 Score =  111 bits (277), Expect = 2e-23
 Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)

Query: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 963  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1022

Query: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 1023 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1082

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 1083 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1134

Query: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 1135 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1191

Query: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2907
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1251

Query: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 1252 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1284

Query: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 1285 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1343

Query: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3086
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1402

Query: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 1403 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1454

Query: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1503

Query: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264
            +         +  +ESQ     E E  ++         K E E  + KQ+ +  L +  +
Sbjct: 1504 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1547

Query: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
            Q+                     + L +   +RA Q+Q AL                   
Sbjct: 1548 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1571

Query: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
                   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 1572 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1627

Query: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
            +   +  L   RW+   N+A     Q E    VAQQ     + L +     EK+    E 
Sbjct: 1628 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1675

Query: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1735

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3557
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795

Query: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1847

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 1848 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1900

Query: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 1901 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1948

Query: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 1949 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2001

Query: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3847
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ E 
Sbjct: 2002 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055

Query: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907
            +A +   Q  E  +EL   L + QS++ QL   A   E  R+  EE  + R         
Sbjct: 2056 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2110

Query: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 3962
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2170

Query: 3963 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4003
             + H K           ++Q L +L  ++ E   Q   +  E++++K + +E        
Sbjct: 2171 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2230

Query: 4004 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4058
                 +V V ME+L  L   ++     +I R    DKD + + +Q++ ++M  + E    
Sbjct: 2231 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2286

Query: 4059 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
            L V  +EA  L   +LAE+      +L    +K+    +++      +  +++QQ+E A+
Sbjct: 2287 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2344

Query: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176
               E+   LQE+ +       ++     E  +   +    E     +   +A + ++ ++
Sbjct: 2345 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2393

Query: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4236
             E  +A  + ++  Q      +  G KL        +  T+ Q +E             I
Sbjct: 2394 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2440

Query: 4237 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4295
            + ++ +H AE L + + E E +K  +Q    E KL+    EE    +Q +L     AL Q
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497

Query: 4296 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4351
                     ++L+  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E  
Sbjct: 2498 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2548

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
             +    L+ S   EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +
Sbjct: 2549 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2600

Query: 4412 LQQWLTDTERHLLA 4425
              Q L +  R  LA
Sbjct: 2601 QLQLLEEQHRAALA 2614



 Score = 94.0 bits (232), Expect = 4e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 954  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1007

Query: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 1008 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1059

Query: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 1060 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1119

Query: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 1120 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1179

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 1180 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1237

Query: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 1238 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1297

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 1298 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1356

Query: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 1357 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1400

Query: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 1401 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1454

Query: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1514

Query: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 1515 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1563

Query: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 1564 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1599

Query: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 1600 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1641

Query: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1700

Query: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 1701 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1754

Query: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1809

Query: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 1810 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865

Query: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 1866 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924

Query: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984

Query: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044

Query: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2095

Query: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 2096 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2155

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 2156 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2209

Query: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 2210 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2265

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 2266 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2314

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 2315 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374

Query: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 2375 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2431

Query: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2489

Query: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 2490 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2546

Query: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2590

Query: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 2591 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2627



 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 1130 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1184

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 1185 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241

Query: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301

Query: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 1302 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1347

Query: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407

Query: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 1408 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1459

Query: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 1460 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1512

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 1513 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1562

Query: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 1563 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1617

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 1618 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1670

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730

Query: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1784

Query: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844

Query: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 1845 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1893

Query: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 1894 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1944

Query: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 1945 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2000

Query: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 2001 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2045

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 2046 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098

Query: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 2099 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150

Query: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2261

Query: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2313

Query: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 2314 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2368

Query: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 2369 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2421

Query: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 2422 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473

Query: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2514



 Score = 78.6 bits (192), Expect = 2e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 516  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 568

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 569  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 624

Query: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 625  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 678

Query: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 679  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 717

Query: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 718  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 766

Query: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 767  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 814

Query: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 815  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 868

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 869  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 923

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 924  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 967

Query: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 968  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1016

Query: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1076

Query: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 1077 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1132

Query: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 1133 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1190

Query: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 1191 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1250

Query: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 1251 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1310

Query: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 1311 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1370

Query: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 1371 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429

Query: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 1430 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1480

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1539

Query: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 1540 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597

Query: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1637

Query: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697

Query: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 1698 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1753

Query: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813

Query: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 1814 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1867

Query: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 1868 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1926

Query: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 1927 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1986

Query: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2046

Query: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 2047 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099

Query: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 2100 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2154

Query: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 2155 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2213

Query: 5067 QQVWLLALERRRKLNDALDRLEELR 5091
            Q++   A E  R+ +   + L  +R
Sbjct: 2214 QRLKAEATEAARQRSQVEEELFSVR 2238



 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1073

Query: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 1074 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1129

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 1130 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1189

Query: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 1190 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1248

Query: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 1249 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1289

Query: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 1290 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1349

Query: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 1350 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1409

Query: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 1410 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1465

Query: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 1466 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1521

Query: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1579

Query: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 1580 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1639

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 1640 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1695

Query: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 1696 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1754

Query: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1807

Query: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 1808 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1857

Query: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 1858 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1896

Query: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 1897 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1955

Query: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1992



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227

Query: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287

Query: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2288 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2344

Query: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2345 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2404

Query: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2464

Query: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 2465 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524

Query: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 2525 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2581

Query: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 2582 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2641

Query: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501
            ++ +        +++  ++ LQ   +  A+
Sbjct: 2642 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2671



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)

Query: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 368  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 427

Query: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 428  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 487

Query: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 488  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 539

Query: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 540  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 599

Query: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4861
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+    
Sbjct: 600  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 644

Query: 4862 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909
                 D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 645  GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 692



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 4461 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4511


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  861 bits (2224), Expect = 0.0
 Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 518  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 578  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 638  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 698  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 758  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 818  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 878  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 938  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997

Query: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 998  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117

Query: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1296

Query: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356

Query: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1413

Query: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1414 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1456

Query: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1457 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506

Query: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1564

Query: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1565 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1620

Query: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1621 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1670

Query: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1671 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1725

Query: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1726 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969
            S S++   +++  A      R+L     R R+L  +        ++  D  +   +A   
Sbjct: 1780 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1834

Query: 1970 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2024
            L   L A  EAT  K  +E IA+  K  +    R+L E +A Q +   +Q A  K     
Sbjct: 1835 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1888

Query: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
                D    L   +      L+   G  ED  +   +  E++       L+++   ++  
Sbjct: 1889 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1938

Query: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
               G  E  L E G++  N+   +D +      E + A RQ  + A  E+ ++  E    
Sbjct: 1939 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1987

Query: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204
                  +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   
Sbjct: 1988 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040

Query: 2205 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2258
            E         E      + Q  QE      + +  L+ L    +        +++A V +
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2099

Query: 2259 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2318
                 ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   
Sbjct: 2100 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159

Query: 2319 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2377
            +    + +E  KK  E+   +  ++++     ++   L    T   K +  +      L 
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2213

Query: 2378 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2432
             E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2266

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2489
            QEE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   L
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325

Query: 2490 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2548
            K +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+E
Sbjct: 2326 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2369

Query: 2549 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2608
            A+ ++ L                   ++ + +++++ + E +  + + E+     +    
Sbjct: 2370 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2411

Query: 2609 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2668
              GE      +  ++   + Q  +    Q     + + +AI +  + +  L+        
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2464

Query: 2669 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2724
             + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E
Sbjct: 2465 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523

Query: 2725 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2784
              KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ 
Sbjct: 2524 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2581

Query: 2785 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
            +   + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633



 Score =  564 bits (1453), Expect = e-159
 Identities = 270/451 (59%), Positives = 362/451 (80%), Gaps = 1/451 (0%)

Query: 30  KDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 89
           +DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMR
Sbjct: 37  QDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 96

Query: 90  FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESE 149
           FH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SE
Sbjct: 97  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE 156

Query: 150 DMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNL 209
           DM+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V  Q+NL
Sbjct: 157 DMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNL 216

Query: 210 ANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGAND 268
            NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP+  +G+ AN+
Sbjct: 217 ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANE 276

Query: 269 VEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEK 328
           ++++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE E+P KE +K
Sbjct: 277 LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 336

Query: 329 SKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQ 388
           ++ K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+
Sbjct: 337 NRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQR 396

Query: 389 IANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDV 448
           I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++R    DV
Sbjct: 397 IVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV 456

Query: 449 QILIDGKYYQADQLVQRVAKLRDEIMALRNE 479
           Q L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 457 QTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 487



 Score =  111 bits (277), Expect = 2e-23
 Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)

Query: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 959  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1018

Query: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1078

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 1079 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1130

Query: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 1131 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187

Query: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2907
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247

Query: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1280

Query: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1339

Query: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3086
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398

Query: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 1399 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450

Query: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1499

Query: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264
            +         +  +ESQ     E E  ++         K E E  + KQ+ +  L +  +
Sbjct: 1500 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1543

Query: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
            Q+                     + L +   +RA Q+Q AL                   
Sbjct: 1544 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1567

Query: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
                   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 1568 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1623

Query: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
            +   +  L   RW+   N+A     Q E    VAQQ     + L +     EK+    E 
Sbjct: 1624 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1671

Query: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3557
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791

Query: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1843

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 1844 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1896

Query: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 1897 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1944

Query: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 1945 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1997

Query: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3847
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ E 
Sbjct: 1998 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051

Query: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907
            +A +   Q  E  +EL   L + QS++ QL   A   E  R+  EE  + R         
Sbjct: 2052 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2106

Query: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 3962
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2166

Query: 3963 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4003
             + H K           ++Q L +L  ++ E   Q   +  E++++K + +E        
Sbjct: 2167 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2226

Query: 4004 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4058
                 +V V ME+L  L   ++     +I R    DKD + + +Q++ ++M  + E    
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2282

Query: 4059 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
            L V  +EA  L   +LAE+      +L    +K+    +++      +  +++QQ+E A+
Sbjct: 2283 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340

Query: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176
               E+   LQE+ +       ++     E  +   +    E     +   +A + ++ ++
Sbjct: 2341 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2389

Query: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4236
             E  +A  + ++  Q      +  G KL        +  T+ Q +E             I
Sbjct: 2390 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2436

Query: 4237 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4295
            + ++ +H AE L + + E E +K  +Q    E KL+    EE    +Q +L     AL Q
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493

Query: 4296 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4351
                     ++L+  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E  
Sbjct: 2494 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2544

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
             +    L+ S   EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +
Sbjct: 2545 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2596

Query: 4412 LQQWLTDTERHLLA 4425
              Q L +  R  LA
Sbjct: 2597 QLQLLEEQHRAALA 2610



 Score = 94.0 bits (232), Expect = 4e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 950  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1003

Query: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 1004 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1055

Query: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 1056 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1115

Query: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 1116 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1175

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 1176 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1233

Query: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 1234 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1352

Query: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 1353 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1396

Query: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 1397 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1450

Query: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510

Query: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 1511 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1559

Query: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 1560 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1595

Query: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 1596 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1637

Query: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1696

Query: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 1697 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1750

Query: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1805

Query: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 1806 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861

Query: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 1862 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920

Query: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980

Query: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040

Query: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2091

Query: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 2092 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2151

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 2152 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2205

Query: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 2206 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2261

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 2262 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2310

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 2311 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370

Query: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 2371 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427

Query: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2485

Query: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 2486 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2542

Query: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2586

Query: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 2587 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2623



 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 1126 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1180

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 1181 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297

Query: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 1298 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1343

Query: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403

Query: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 1404 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1455

Query: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 1456 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1508

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 1509 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1558

Query: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 1559 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 1614 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1666

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726

Query: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1780

Query: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840

Query: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 1841 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1889

Query: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 1890 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1940

Query: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 1941 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996

Query: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 1997 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2041

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 2042 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094

Query: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 2095 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146

Query: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2257

Query: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2309

Query: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 2310 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2364

Query: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 2365 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2417

Query: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 2418 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469

Query: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2510



 Score = 78.6 bits (192), Expect = 2e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 512  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 564

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 565  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 620

Query: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 621  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 674

Query: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 675  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 713

Query: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 714  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 762

Query: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 763  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 810

Query: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 811  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 864

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 865  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 919

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 920  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 963

Query: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 964  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1012

Query: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1072

Query: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 1073 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1128

Query: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 1129 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1186

Query: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246

Query: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 1247 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1306

Query: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366

Query: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425

Query: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 1426 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1476

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1535

Query: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 1536 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593

Query: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1633

Query: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693

Query: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 1694 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749

Query: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809

Query: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 1810 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1863

Query: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 1864 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1922

Query: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 1923 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1982

Query: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2042

Query: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 2043 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095

Query: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2150

Query: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 2151 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2209

Query: 5067 QQVWLLALERRRKLNDALDRLEELR 5091
            Q++   A E  R+ +   + L  +R
Sbjct: 2210 QRLKAEATEAARQRSQVEEELFSVR 2234



 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1069

Query: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 1070 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1125

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 1126 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1185

Query: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 1186 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1244

Query: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 1245 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1285

Query: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 1286 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1345

Query: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 1346 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1405

Query: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 1406 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1461

Query: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 1462 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1517

Query: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1575

Query: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 1576 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1635

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 1636 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691

Query: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1750

Query: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1803

Query: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 1804 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1853

Query: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 1854 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1892

Query: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 1893 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1951

Query: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223

Query: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2284 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2340

Query: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2341 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2400

Query: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460

Query: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520

Query: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 2521 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577

Query: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2637

Query: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501
            ++ +        +++  ++ LQ   +  A+
Sbjct: 2638 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2667



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)

Query: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 364  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 423

Query: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 424  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 483

Query: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 484  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 535

Query: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 536  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 595

Query: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4861
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+    
Sbjct: 596  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 640

Query: 4862 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909
                 D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 641  GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 688



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 4457 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4507


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  861 bits (2224), Expect = 0.0
 Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 486  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 546  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 605

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 606  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 665

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 666  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 725

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 726  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 786  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 845

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 846  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 905

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 906  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 965

Query: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 966  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1026 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085

Query: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1145

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205

Query: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1264

Query: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1265 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1324

Query: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1325 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1381

Query: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1382 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1424

Query: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1425 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474

Query: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1475 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1532

Query: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1533 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1588

Query: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1589 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1638

Query: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1639 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1693

Query: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1694 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747

Query: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969
            S S++   +++  A      R+L     R R+L  +        ++  D  +   +A   
Sbjct: 1748 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1802

Query: 1970 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2024
            L   L A  EAT  K  +E IA+  K  +    R+L E +A Q +   +Q A  K     
Sbjct: 1803 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1856

Query: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
                D    L   +      L+   G  ED  +   +  E++       L+++   ++  
Sbjct: 1857 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1906

Query: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
               G  E  L E G++  N+   +D +      E + A RQ  + A  E+ ++  E    
Sbjct: 1907 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1955

Query: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204
                  +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   
Sbjct: 1956 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008

Query: 2205 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2258
            E         E      + Q  QE      + +  L+ L    +        +++A V +
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2067

Query: 2259 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2318
                 ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   
Sbjct: 2068 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2127

Query: 2319 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2377
            +    + +E  KK  E+   +  ++++     ++   L    T   K +  +      L 
Sbjct: 2128 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2181

Query: 2378 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2432
             E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  
Sbjct: 2182 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2234

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2489
            QEE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   L
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293

Query: 2490 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2548
            K +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+E
Sbjct: 2294 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2337

Query: 2549 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2608
            A+ ++ L                   ++ + +++++ + E +  + + E+     +    
Sbjct: 2338 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2379

Query: 2609 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2668
              GE      +  ++   + Q  +    Q     + + +AI +  + +  L+        
Sbjct: 2380 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2432

Query: 2669 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2724
             + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E
Sbjct: 2433 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2491

Query: 2725 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2784
              KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ 
Sbjct: 2492 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2549

Query: 2785 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
            +   + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2550 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2601



 Score =  563 bits (1452), Expect = e-159
 Identities = 270/450 (60%), Positives = 361/450 (80%), Gaps = 1/450 (0%)

Query: 31  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 90
           DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 6   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 65

Query: 91  HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 150
           H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 66  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 125

Query: 151 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 210
           M+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V  Q+NL 
Sbjct: 126 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 185

Query: 211 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 269
           NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP+  +G+ AN++
Sbjct: 186 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 245

Query: 270 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 329
           +++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE E+P KE +K+
Sbjct: 246 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 305

Query: 330 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 389
           + K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 306 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 365

Query: 390 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 449
             ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++R    DVQ
Sbjct: 366 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 425

Query: 450 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 479
            L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 426 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 455



 Score =  111 bits (277), Expect = 2e-23
 Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)

Query: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 927  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 986

Query: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 987  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1046

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 1047 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1098

Query: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 1099 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1155

Query: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2907
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215

Query: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 1216 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1248

Query: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 1249 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1307

Query: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3086
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1366

Query: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 1367 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1418

Query: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1467

Query: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264
            +         +  +ESQ     E E  ++         K E E  + KQ+ +  L +  +
Sbjct: 1468 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1511

Query: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
            Q+                     + L +   +RA Q+Q AL                   
Sbjct: 1512 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1535

Query: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
                   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 1536 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1591

Query: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
            +   +  L   RW+   N+A     Q E    VAQQ     + L +     EK+    E 
Sbjct: 1592 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1639

Query: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1699

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3557
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759

Query: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1811

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 1812 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1864

Query: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 1865 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1912

Query: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 1913 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1965

Query: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3847
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ E 
Sbjct: 1966 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019

Query: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907
            +A +   Q  E  +EL   L + QS++ QL   A   E  R+  EE  + R         
Sbjct: 2020 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2074

Query: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 3962
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2134

Query: 3963 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4003
             + H K           ++Q L +L  ++ E   Q   +  E++++K + +E        
Sbjct: 2135 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2194

Query: 4004 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4058
                 +V V ME+L  L   ++     +I R    DKD + + +Q++ ++M  + E    
Sbjct: 2195 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2250

Query: 4059 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
            L V  +EA  L   +LAE+      +L    +K+    +++      +  +++QQ+E A+
Sbjct: 2251 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2308

Query: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176
               E+   LQE+ +       ++     E  +   +    E     +   +A + ++ ++
Sbjct: 2309 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2357

Query: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4236
             E  +A  + ++  Q      +  G KL        +  T+ Q +E             I
Sbjct: 2358 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2404

Query: 4237 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4295
            + ++ +H AE L + + E E +K  +Q    E KL+    EE    +Q +L     AL Q
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461

Query: 4296 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4351
                     ++L+  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E  
Sbjct: 2462 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2512

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
             +    L+ S   EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +
Sbjct: 2513 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2564

Query: 4412 LQQWLTDTERHLLA 4425
              Q L +  R  LA
Sbjct: 2565 QLQLLEEQHRAALA 2578



 Score = 94.0 bits (232), Expect = 4e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 918  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 971

Query: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 972  VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1023

Query: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 1024 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1083

Query: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 1084 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1143

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 1144 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1201

Query: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 1202 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1261

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 1262 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1320

Query: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 1321 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1364

Query: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 1365 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1418

Query: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1478

Query: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 1479 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1527

Query: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 1528 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1563

Query: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 1564 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1605

Query: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1664

Query: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 1665 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1718

Query: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1773

Query: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 1774 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829

Query: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 1830 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888

Query: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948

Query: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008

Query: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2059

Query: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 2060 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2119

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 2120 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2173

Query: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 2174 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2229

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 2230 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2278

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 2279 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338

Query: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 2339 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2395

Query: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2453

Query: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 2454 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2510

Query: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 2511 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2554

Query: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 2555 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2591



 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 1094 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1148

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 1149 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205

Query: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265

Query: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 1266 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1311

Query: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371

Query: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 1372 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1423

Query: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 1424 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1476

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 1477 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1526

Query: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 1527 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1581

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 1582 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1634

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694

Query: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1748

Query: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808

Query: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 1809 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1857

Query: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 1858 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1908

Query: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 1909 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1964

Query: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 1965 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2009

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 2010 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062

Query: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 2063 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114

Query: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2225

Query: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2277

Query: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 2278 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2332

Query: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 2333 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2385

Query: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 2386 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437

Query: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2478



 Score = 78.6 bits (192), Expect = 2e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 480  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 532

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 533  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 588

Query: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 589  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 642

Query: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 643  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 681

Query: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 682  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 730

Query: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 731  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 778

Query: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 779  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 832

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 833  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 887

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 888  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 931

Query: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 932  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 980

Query: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 981  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1040

Query: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 1041 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1096

Query: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 1097 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1154

Query: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 1155 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1214

Query: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 1215 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1274

Query: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 1275 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1334

Query: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 1335 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393

Query: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 1394 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1444

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1503

Query: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 1504 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561

Query: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1601

Query: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661

Query: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 1662 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1717

Query: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 1718 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1777

Query: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 1778 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1831

Query: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 1832 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1890

Query: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 1891 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1950

Query: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2010

Query: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 2011 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063

Query: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 2064 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2118

Query: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 2119 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2177

Query: 5067 QQVWLLALERRRKLNDALDRLEELR 5091
            Q++   A E  R+ +   + L  +R
Sbjct: 2178 QRLKAEATEAARQRSQVEEELFSVR 2202



 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 981  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1037

Query: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 1038 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1093

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 1094 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1153

Query: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 1154 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1212

Query: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 1213 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1253

Query: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 1254 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1313

Query: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 1314 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1373

Query: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 1374 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1429

Query: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 1430 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1485

Query: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1543

Query: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 1544 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1603

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 1604 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1659

Query: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1718

Query: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1771

Query: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 1772 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1821

Query: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 1822 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1860

Query: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 1861 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1919

Query: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1956



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191

Query: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251

Query: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2252 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2308

Query: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2309 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2368

Query: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2428

Query: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 2429 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488

Query: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 2489 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2545

Query: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 2546 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2605

Query: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501
            ++ +        +++  ++ LQ   +  A+
Sbjct: 2606 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2635



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)

Query: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 332  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 391

Query: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 392  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 451

Query: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 452  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 503

Query: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 504  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 563

Query: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4861
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+    
Sbjct: 564  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 608

Query: 4862 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909
                 D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 609  GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 656



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 4425 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4475


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  861 bits (2224), Expect = 0.0
 Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 655  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 715  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 775  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 835  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 895  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 955  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134

Query: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254

Query: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374

Query: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433

Query: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493

Query: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1550

Query: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1551 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1593

Query: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1594 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643

Query: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1644 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1701

Query: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1702 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1757

Query: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1807

Query: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1808 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1862

Query: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1863 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916

Query: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969
            S S++   +++  A      R+L     R R+L  +        ++  D  +   +A   
Sbjct: 1917 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1971

Query: 1970 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2024
            L   L A  EAT  K  +E IA+  K  +    R+L E +A Q +   +Q A  K     
Sbjct: 1972 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 2025

Query: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
                D    L   +      L+   G  ED  +   +  E++       L+++   ++  
Sbjct: 2026 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 2075

Query: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
               G  E  L E G++  N+   +D +      E + A RQ  + A  E+ ++  E    
Sbjct: 2076 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 2124

Query: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204
                  +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   
Sbjct: 2125 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177

Query: 2205 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2258
            E         E      + Q  QE      + +  L+ L    +        +++A V +
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2236

Query: 2259 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2318
                 ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   
Sbjct: 2237 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2296

Query: 2319 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2377
            +    + +E  KK  E+   +  ++++     ++   L    T   K +  +      L 
Sbjct: 2297 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2350

Query: 2378 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2432
             E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  
Sbjct: 2351 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2403

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2489
            QEE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   L
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462

Query: 2490 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2548
            K +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+E
Sbjct: 2463 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2506

Query: 2549 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2608
            A+ ++ L                   ++ + +++++ + E +  + + E+     +    
Sbjct: 2507 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2548

Query: 2609 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2668
              GE      +  ++   + Q  +    Q     + + +AI +  + +  L+        
Sbjct: 2549 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2601

Query: 2669 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2724
             + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E
Sbjct: 2602 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2660

Query: 2725 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2784
              KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ 
Sbjct: 2661 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2718

Query: 2785 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
            +   + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2719 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770



 Score =  563 bits (1452), Expect = e-159
 Identities = 270/450 (60%), Positives = 361/450 (80%), Gaps = 1/450 (0%)

Query: 31  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 90
           DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234

Query: 91  HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 150
           H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294

Query: 151 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 210
           M+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V  Q+NL 
Sbjct: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354

Query: 211 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 269
           NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP+  +G+ AN++
Sbjct: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414

Query: 270 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 329
           +++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE E+P KE +K+
Sbjct: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474

Query: 330 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 389
           + K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534

Query: 390 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 449
             ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++R    DVQ
Sbjct: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594

Query: 450 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 479
            L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624



 Score =  111 bits (277), Expect = 2e-23
 Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)

Query: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 1096 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1155

Query: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1215

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1267

Query: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 1268 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324

Query: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2907
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384

Query: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1417

Query: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 1418 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1476

Query: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3086
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535

Query: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 1536 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587

Query: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1636

Query: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264
            +         +  +ESQ     E E  ++         K E E  + KQ+ +  L +  +
Sbjct: 1637 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1680

Query: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
            Q+                     + L +   +RA Q+Q AL                   
Sbjct: 1681 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1704

Query: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
                   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 1705 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1760

Query: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
            +   +  L   RW+   N+A     Q E    VAQQ     + L +     EK+    E 
Sbjct: 1761 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1808

Query: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3557
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928

Query: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1980

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 1981 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 2033

Query: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 2034 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 2081

Query: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 2082 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2134

Query: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3847
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ E 
Sbjct: 2135 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188

Query: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907
            +A +   Q  E  +EL   L + QS++ QL   A   E  R+  EE  + R         
Sbjct: 2189 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2243

Query: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 3962
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2303

Query: 3963 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4003
             + H K           ++Q L +L  ++ E   Q   +  E++++K + +E        
Sbjct: 2304 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2363

Query: 4004 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4058
                 +V V ME+L  L   ++     +I R    DKD + + +Q++ ++M  + E    
Sbjct: 2364 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2419

Query: 4059 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
            L V  +EA  L   +LAE+      +L    +K+    +++      +  +++QQ+E A+
Sbjct: 2420 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477

Query: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176
               E+   LQE+ +       ++     E  +   +    E     +   +A + ++ ++
Sbjct: 2478 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2526

Query: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4236
             E  +A  + ++  Q      +  G KL        +  T+ Q +E             I
Sbjct: 2527 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2573

Query: 4237 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4295
            + ++ +H AE L + + E E +K  +Q    E KL+    EE    +Q +L     AL Q
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630

Query: 4296 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4351
                     ++L+  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E  
Sbjct: 2631 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2681

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
             +    L+ S   EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +
Sbjct: 2682 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2733

Query: 4412 LQQWLTDTERHLLA 4425
              Q L +  R  LA
Sbjct: 2734 QLQLLEEQHRAALA 2747



 Score = 94.0 bits (232), Expect = 4e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1140

Query: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 1141 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1192

Query: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 1193 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1252

Query: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 1253 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1312

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 1313 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1370

Query: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 1371 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 1431 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1489

Query: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 1490 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1533

Query: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1587

Query: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647

Query: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 1648 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1696

Query: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 1697 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1732

Query: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 1733 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1774

Query: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1833

Query: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 1834 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1887

Query: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1942

Query: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 1943 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998

Query: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 1999 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057

Query: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117

Query: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177

Query: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228

Query: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 2289 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342

Query: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 2343 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2398

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 2399 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2447

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507

Query: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 2508 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564

Query: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2622

Query: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 2623 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679

Query: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2723

Query: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 2724 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2760



 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 1263 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1317

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 1318 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374

Query: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434

Query: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 1435 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1480

Query: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540

Query: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1592

Query: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 1593 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1645

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 1646 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1695

Query: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 1696 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 1751 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1803

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863

Query: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1917

Query: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977

Query: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 1978 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 2026

Query: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 2027 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 2077

Query: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 2078 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133

Query: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 2134 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2178

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 2179 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231

Query: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 2232 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283

Query: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2394

Query: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2446

Query: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 2447 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2501

Query: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 2502 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2554

Query: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 2555 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606

Query: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647



 Score = 78.6 bits (192), Expect = 2e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 649  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 701

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 702  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 757

Query: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 758  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 811

Query: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 812  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 850

Query: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 851  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 899

Query: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 900  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 947

Query: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 948  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 1001

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 1002 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1056

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 1057 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1100

Query: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 1101 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1149

Query: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1209

Query: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 1210 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1265

Query: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1323

Query: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383

Query: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443

Query: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503

Query: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562

Query: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 1563 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1613

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1672

Query: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 1673 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730

Query: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1770

Query: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830

Query: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 1831 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886

Query: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946

Query: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 1947 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 2000

Query: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 2001 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059

Query: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119

Query: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179

Query: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 2180 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232

Query: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2287

Query: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 2288 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2346

Query: 5067 QQVWLLALERRRKLNDALDRLEELR 5091
            Q++   A E  R+ +   + L  +R
Sbjct: 2347 QRLKAEATEAARQRSQVEEELFSVR 2371



 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1206

Query: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1262

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322

Query: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 1323 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1381

Query: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 1382 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1422

Query: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 1423 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1482

Query: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1542

Query: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 1543 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1598

Query: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 1599 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1654

Query: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712

Query: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 1773 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828

Query: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 1829 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887

Query: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1940

Query: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 1941 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1990

Query: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 1991 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 2029

Query: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 2088

Query: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360

Query: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420

Query: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2421 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477

Query: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537

Query: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597

Query: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657

Query: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 2658 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714

Query: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2774

Query: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501
            ++ +        +++  ++ LQ   +  A+
Sbjct: 2775 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2804



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)

Query: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 501  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 560

Query: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 561  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 620

Query: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 621  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 672

Query: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 673  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 732

Query: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4861
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+    
Sbjct: 733  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 777

Query: 4862 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909
                 D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 778  GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 825



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 4594 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4644


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  861 bits (2224), Expect = 0.0
 Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975

Query: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095

Query: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215

Query: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274

Query: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334

Query: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1391

Query: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1392 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1434

Query: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1435 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484

Query: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1485 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1542

Query: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1543 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1598

Query: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1648

Query: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1649 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1703

Query: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1704 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757

Query: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969
            S S++   +++  A      R+L     R R+L  +        ++  D  +   +A   
Sbjct: 1758 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1812

Query: 1970 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2024
            L   L A  EAT  K  +E IA+  K  +    R+L E +A Q +   +Q A  K     
Sbjct: 1813 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1866

Query: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
                D    L   +      L+   G  ED  +   +  E++       L+++   ++  
Sbjct: 1867 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1916

Query: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
               G  E  L E G++  N+   +D +      E + A RQ  + A  E+ ++  E    
Sbjct: 1917 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1965

Query: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204
                  +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   
Sbjct: 1966 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018

Query: 2205 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2258
            E         E      + Q  QE      + +  L+ L    +        +++A V +
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2077

Query: 2259 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2318
                 ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   
Sbjct: 2078 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2137

Query: 2319 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2377
            +    + +E  KK  E+   +  ++++     ++   L    T   K +  +      L 
Sbjct: 2138 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2191

Query: 2378 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2432
             E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  
Sbjct: 2192 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2244

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2489
            QEE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   L
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303

Query: 2490 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2548
            K +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+E
Sbjct: 2304 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2347

Query: 2549 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2608
            A+ ++ L                   ++ + +++++ + E +  + + E+     +    
Sbjct: 2348 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2389

Query: 2609 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2668
              GE      +  ++   + Q  +    Q     + + +AI +  + +  L+        
Sbjct: 2390 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2442

Query: 2669 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2724
             + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E
Sbjct: 2443 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2501

Query: 2725 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2784
              KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ 
Sbjct: 2502 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2559

Query: 2785 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
            +   + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2560 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611



 Score =  567 bits (1462), Expect = e-161
 Identities = 272/461 (59%), Positives = 367/461 (79%), Gaps = 1/461 (0%)

Query: 20  QAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGD 79
           +A ++ +   KDERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD
Sbjct: 5   RAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGD 64

Query: 80  TLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQI 139
           +LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQI
Sbjct: 65  SLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI 124

Query: 140 SDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLID 199
           SDI V+G+SEDM+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LID
Sbjct: 125 SDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLID 184

Query: 200 MNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP 258
           MN V  Q+NL NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP
Sbjct: 185 MNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP 244

Query: 259 EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 318
           +  +G+ AN+++++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE
Sbjct: 245 DVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 304

Query: 319 TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP 378
            E+P KE +K++ K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR 
Sbjct: 305 MELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRS 364

Query: 379 EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE 438
           E ERLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + +
Sbjct: 365 EFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKAD 424

Query: 439 NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 479
           +++R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 425 SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465



 Score =  111 bits (277), Expect = 2e-23
 Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)

Query: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 937  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 996

Query: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 997  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1056

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 1057 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1108

Query: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 1109 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165

Query: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2907
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225

Query: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1258

Query: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 1259 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1317

Query: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3086
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1376

Query: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 1377 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428

Query: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1477

Query: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264
            +         +  +ESQ     E E  ++         K E E  + KQ+ +  L +  +
Sbjct: 1478 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1521

Query: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
            Q+                     + L +   +RA Q+Q AL                   
Sbjct: 1522 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1545

Query: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
                   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 1546 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1601

Query: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
            +   +  L   RW+   N+A     Q E    VAQQ     + L +     EK+    E 
Sbjct: 1602 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1649

Query: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3557
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769

Query: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1821

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 1822 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1874

Query: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 1875 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1922

Query: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 1923 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1975

Query: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3847
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ E 
Sbjct: 1976 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029

Query: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907
            +A +   Q  E  +EL   L + QS++ QL   A   E  R+  EE  + R         
Sbjct: 2030 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2084

Query: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 3962
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2144

Query: 3963 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4003
             + H K           ++Q L +L  ++ E   Q   +  E++++K + +E        
Sbjct: 2145 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2204

Query: 4004 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4058
                 +V V ME+L  L   ++     +I R    DKD + + +Q++ ++M  + E    
Sbjct: 2205 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2260

Query: 4059 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
            L V  +EA  L   +LAE+      +L    +K+    +++      +  +++QQ+E A+
Sbjct: 2261 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318

Query: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176
               E+   LQE+ +       ++     E  +   +    E     +   +A + ++ ++
Sbjct: 2319 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2367

Query: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4236
             E  +A  + ++  Q      +  G KL        +  T+ Q +E             I
Sbjct: 2368 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2414

Query: 4237 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4295
            + ++ +H AE L + + E E +K  +Q    E KL+    EE    +Q +L     AL Q
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471

Query: 4296 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4351
                     ++L+  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E  
Sbjct: 2472 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2522

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
             +    L+ S   EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +
Sbjct: 2523 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2574

Query: 4412 LQQWLTDTERHLLA 4425
              Q L +  R  LA
Sbjct: 2575 QLQLLEEQHRAALA 2588



 Score = 94.0 bits (232), Expect = 4e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 928  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 981

Query: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 982  VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1033

Query: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 1034 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1093

Query: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 1094 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1153

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 1154 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1211

Query: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 1212 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 1272 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1330

Query: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 1331 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1374

Query: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1428

Query: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488

Query: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 1489 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1537

Query: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 1538 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1573

Query: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 1574 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1615

Query: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1674

Query: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 1675 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1728

Query: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1783

Query: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 1784 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839

Query: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 1840 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898

Query: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958

Query: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018

Query: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069

Query: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 2130 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183

Query: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 2184 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2239

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 2240 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2288

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348

Query: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 2349 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405

Query: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2463

Query: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 2464 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520

Query: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2564

Query: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 2565 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2601



 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 1104 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1158

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 1159 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215

Query: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275

Query: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 1276 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1321

Query: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381

Query: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1433

Query: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 1434 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1486

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 1487 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1536

Query: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 1537 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 1592 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1644

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704

Query: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1758

Query: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818

Query: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 1819 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1867

Query: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 1868 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1918

Query: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 1919 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974

Query: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 1975 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2019

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 2020 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072

Query: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 2073 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124

Query: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2235

Query: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2287

Query: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 2288 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2342

Query: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 2343 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2395

Query: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 2396 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447

Query: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488



 Score = 78.6 bits (192), Expect = 2e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 490  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 542

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 543  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 598

Query: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 599  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 652

Query: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 653  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 691

Query: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 692  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 740

Query: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 741  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 788

Query: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 789  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 842

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 843  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 897

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 898  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 941

Query: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 942  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 990

Query: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1050

Query: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 1051 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1106

Query: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1164

Query: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224

Query: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284

Query: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344

Query: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403

Query: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 1404 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1454

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1513

Query: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 1514 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571

Query: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1611

Query: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671

Query: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 1672 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727

Query: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787

Query: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 1788 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1841

Query: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 1842 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1900

Query: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960

Query: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020

Query: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 2021 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073

Query: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2128

Query: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 2129 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2187

Query: 5067 QQVWLLALERRRKLNDALDRLEELR 5091
            Q++   A E  R+ +   + L  +R
Sbjct: 2188 QRLKAEATEAARQRSQVEEELFSVR 2212



 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1047

Query: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1103

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1163

Query: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 1164 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1222

Query: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 1223 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1263

Query: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 1264 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1323

Query: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1383

Query: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 1384 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1439

Query: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 1440 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1495

Query: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553

Query: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 1614 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669

Query: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 1670 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728

Query: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1781

Query: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 1782 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1831

Query: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 1832 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1870

Query: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1929

Query: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201

Query: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261

Query: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2262 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318

Query: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378

Query: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438

Query: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498

Query: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 2499 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555

Query: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2615

Query: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501
            ++ +        +++  ++ LQ   +  A+
Sbjct: 2616 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2645



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)

Query: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 342  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 401

Query: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 402  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 461

Query: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 462  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 513

Query: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 514  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 573

Query: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4861
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+    
Sbjct: 574  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 618

Query: 4862 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909
                 D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 619  GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 666



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 4435 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4485


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  861 bits (2224), Expect = 0.0
 Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 504  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 564  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 623

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 624  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 683

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 684  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 743

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 744  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 804  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 863

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 864  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 923

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 924  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 983

Query: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 984  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1044 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103

Query: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1163

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223

Query: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1282

Query: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1342

Query: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1399

Query: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1400 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1442

Query: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1443 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492

Query: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1493 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1550

Query: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1551 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1606

Query: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1607 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1656

Query: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1657 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1711

Query: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1712 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765

Query: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969
            S S++   +++  A      R+L     R R+L  +        ++  D  +   +A   
Sbjct: 1766 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1820

Query: 1970 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2024
            L   L A  EAT  K  +E IA+  K  +    R+L E +A Q +   +Q A  K     
Sbjct: 1821 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1874

Query: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
                D    L   +      L+   G  ED  +   +  E++       L+++   ++  
Sbjct: 1875 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1924

Query: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
               G  E  L E G++  N+   +D +      E + A RQ  + A  E+ ++  E    
Sbjct: 1925 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 1973

Query: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204
                  +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   
Sbjct: 1974 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026

Query: 2205 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2258
            E         E      + Q  QE      + +  L+ L    +        +++A V +
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2085

Query: 2259 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2318
                 ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   
Sbjct: 2086 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2145

Query: 2319 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2377
            +    + +E  KK  E+   +  ++++     ++   L    T   K +  +      L 
Sbjct: 2146 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2199

Query: 2378 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2432
             E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  
Sbjct: 2200 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2252

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2489
            QEE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   L
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311

Query: 2490 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2548
            K +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+E
Sbjct: 2312 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2355

Query: 2549 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2608
            A+ ++ L                   ++ + +++++ + E +  + + E+     +    
Sbjct: 2356 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2397

Query: 2609 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2668
              GE      +  ++   + Q  +    Q     + + +AI +  + +  L+        
Sbjct: 2398 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2450

Query: 2669 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2724
             + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E
Sbjct: 2451 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2509

Query: 2725 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2784
              KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ 
Sbjct: 2510 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2567

Query: 2785 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
            +   + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2568 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2619



 Score =  588 bits (1515), Expect = e-167
 Identities = 280/467 (59%), Positives = 377/467 (80%), Gaps = 1/467 (0%)

Query: 14  EEQEYLQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLL 73
           +EQ+++QAYE+V E+YKDERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLL
Sbjct: 7   DEQDFIQAYEEVREKYKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLL 66

Query: 74  EVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTI 133
           EVLSGD+LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTI
Sbjct: 67  EVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTI 126

Query: 134 ILHFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKY 193
           ILHFQISDI V+G+SEDM+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH++
Sbjct: 127 ILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRH 186

Query: 194 RPDLIDMNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYD 252
           +P LIDMN V  Q+NL NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYD
Sbjct: 187 KPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYD 246

Query: 253 AFPKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQ 312
           A P+VP+  +G+ AN+++++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q
Sbjct: 247 AMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQ 306

Query: 313 YLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLER 372
           +L+FKE E+P KE +K++ K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LER
Sbjct: 307 FLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILER 366

Query: 373 EKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAG 432
           EK LR E ERLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+  
Sbjct: 367 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 426

Query: 433 YILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 479
            + + ++++R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 427 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 473



 Score =  111 bits (277), Expect = 2e-23
 Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)

Query: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 945  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1004

Query: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 1005 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1064

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 1065 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1116

Query: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 1117 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1173

Query: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2907
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 1174 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1233

Query: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 1234 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1266

Query: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 1267 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1325

Query: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3086
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1384

Query: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 1385 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1436

Query: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1485

Query: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264
            +         +  +ESQ     E E  ++         K E E  + KQ+ +  L +  +
Sbjct: 1486 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1529

Query: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
            Q+                     + L +   +RA Q+Q AL                   
Sbjct: 1530 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1553

Query: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
                   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 1554 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1609

Query: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
            +   +  L   RW+   N+A     Q E    VAQQ     + L +     EK+    E 
Sbjct: 1610 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1657

Query: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1717

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3557
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777

Query: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1829

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 1830 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1882

Query: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 1883 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1930

Query: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 1931 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1983

Query: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3847
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ E 
Sbjct: 1984 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2037

Query: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907
            +A +   Q  E  +EL   L + QS++ QL   A   E  R+  EE  + R         
Sbjct: 2038 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2092

Query: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 3962
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2152

Query: 3963 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4003
             + H K           ++Q L +L  ++ E   Q   +  E++++K + +E        
Sbjct: 2153 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2212

Query: 4004 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4058
                 +V V ME+L  L   ++     +I R    DKD + + +Q++ ++M  + E    
Sbjct: 2213 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2268

Query: 4059 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
            L V  +EA  L   +LAE+      +L    +K+    +++      +  +++QQ+E A+
Sbjct: 2269 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2326

Query: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176
               E+   LQE+ +       ++     E  +   +    E     +   +A + ++ ++
Sbjct: 2327 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2375

Query: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4236
             E  +A  + ++  Q      +  G KL        +  T+ Q +E             I
Sbjct: 2376 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2422

Query: 4237 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4295
            + ++ +H AE L + + E E +K  +Q    E KL+    EE    +Q +L     AL Q
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479

Query: 4296 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4351
                     ++L+  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E  
Sbjct: 2480 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2530

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
             +    L+ S   EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +
Sbjct: 2531 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2582

Query: 4412 LQQWLTDTERHLLA 4425
              Q L +  R  LA
Sbjct: 2583 QLQLLEEQHRAALA 2596



 Score = 94.0 bits (232), Expect = 4e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 936  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 989

Query: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 990  VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1041

Query: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 1042 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1101

Query: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 1102 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1161

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 1162 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1219

Query: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 1220 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1279

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 1280 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1338

Query: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 1339 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1382

Query: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 1383 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1436

Query: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1496

Query: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 1497 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1545

Query: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 1546 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1581

Query: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 1582 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1623

Query: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1682

Query: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 1683 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1736

Query: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1791

Query: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 1792 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1847

Query: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 1848 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1906

Query: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1966

Query: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 1967 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026

Query: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2077

Query: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 2078 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2137

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 2138 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2191

Query: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 2192 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2247

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 2248 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2296

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 2297 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356

Query: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 2357 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2413

Query: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2471

Query: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 2472 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2528

Query: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 2529 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2572

Query: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 2573 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2609



 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 1112 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1166

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 1167 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223

Query: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283

Query: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 1284 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1329

Query: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389

Query: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 1390 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1441

Query: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 1442 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1494

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 1495 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1544

Query: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 1545 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1599

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 1600 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1652

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712

Query: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1766

Query: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826

Query: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 1827 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1875

Query: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 1876 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1926

Query: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 1927 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1982

Query: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 1983 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2027

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 2028 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080

Query: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 2081 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132

Query: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2243

Query: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2295

Query: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 2296 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2350

Query: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 2351 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2403

Query: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 2404 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2455

Query: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 2456 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2496



 Score = 78.6 bits (192), Expect = 2e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 498  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 550

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 551  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 606

Query: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 607  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 660

Query: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 661  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 699

Query: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 700  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 748

Query: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 749  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 796

Query: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 797  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 850

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 851  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 905

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 906  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 949

Query: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 950  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 998

Query: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 999  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1058

Query: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 1059 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1114

Query: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 1115 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1172

Query: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 1173 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1232

Query: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 1233 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1292

Query: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 1293 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1352

Query: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 1353 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411

Query: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 1412 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1462

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1521

Query: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 1522 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1579

Query: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 1580 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1619

Query: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679

Query: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 1680 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1735

Query: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 1736 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1795

Query: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 1796 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1849

Query: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 1850 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1908

Query: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 1909 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1968

Query: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2028

Query: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 2029 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081

Query: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 2082 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2136

Query: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 2137 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2195

Query: 5067 QQVWLLALERRRKLNDALDRLEELR 5091
            Q++   A E  R+ +   + L  +R
Sbjct: 2196 QRLKAEATEAARQRSQVEEELFSVR 2220



 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 999  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1055

Query: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 1056 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1111

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1171

Query: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 1172 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1230

Query: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 1231 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1271

Query: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 1272 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1331

Query: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 1332 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1391

Query: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 1392 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1447

Query: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 1448 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1503

Query: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1561

Query: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 1562 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1621

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 1622 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1677

Query: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 1678 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1736

Query: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1789

Query: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 1790 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1839

Query: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 1840 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1878

Query: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 1879 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1937

Query: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1974



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2209

Query: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2210 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2269

Query: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2270 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2326

Query: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2327 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2386

Query: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2446

Query: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 2447 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2506

Query: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 2507 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2563

Query: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 2564 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2623

Query: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501
            ++ +        +++  ++ LQ   +  A+
Sbjct: 2624 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2653



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)

Query: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 350  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 409

Query: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 410  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 469

Query: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 470  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 521

Query: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 522  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 581

Query: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4861
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+    
Sbjct: 582  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 626

Query: 4862 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909
                 D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 627  GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 674



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 4443 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4493


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  861 bits (2224), Expect = 0.0
 Identities = 637/2272 (28%), Positives = 1151/2272 (50%), Gaps = 200/2272 (8%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 545  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 604

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 605  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 664

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 665  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 724

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 725  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 784

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 785  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 844

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 845  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 904

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 905  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 964

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 965  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1024

Query: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1025 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1084

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1085 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1144

Query: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1145 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1204

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264

Query: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1323

Query: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1324 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1383

Query: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1440

Query: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1441 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1483

Query: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1484 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533

Query: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1534 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1591

Query: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1592 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1647

Query: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1648 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1697

Query: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1698 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1752

Query: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1753 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806

Query: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969
            S S++   +++  A      R+L     R R+L  +        ++  D  +   +A   
Sbjct: 1807 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1861

Query: 1970 LLAGLQAC-EATASKHLSEPIAVDPKNLQ----RQLEETKALQGQISSQQVAVEKLKKTA 2024
            L   L A  EAT  K  +E IA+  K  +    R+L E +A Q +   +Q A  K     
Sbjct: 1862 LAEKLAAIGEATRLKTEAE-IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK----- 1915

Query: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
                D    L   +      L+   G  ED  +   +  E++       L+++   ++  
Sbjct: 1916 ---ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEI-------LALKASFEKAA 1965

Query: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
               G  E  L E G++  N+   +D +      E + A RQ  + A  E+ ++  E    
Sbjct: 1966 --AGKAELEL-ELGRIRSNA---EDTLRSKEQAELE-AARQRQLAAEEERRRREAE---- 2014

Query: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204
                  +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   
Sbjct: 2015 ------ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067

Query: 2205 EVDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLE 2258
            E         E      + Q  QE      + +  L+ L    +        +++A V +
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-Q 2126

Query: 2259 KTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGA 2318
                 ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   
Sbjct: 2127 AEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2186

Query: 2319 EDLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLN 2377
            +    + +E  KK  E+   +  ++++     ++   L    T   K +  +      L 
Sbjct: 2187 KQAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLK 2240

Query: 2378 GEGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKA 2432
             E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  
Sbjct: 2241 AEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFL 2293

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---L 2489
            QEE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   L
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352

Query: 2490 KDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVE 2548
            K +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+E
Sbjct: 2353 KAE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLE 2396

Query: 2549 AQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILS 2608
            A+ ++ L                   ++ + +++++ + E +  + + E+     +    
Sbjct: 2397 AERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE 2438

Query: 2609 RPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSD 2668
              GE      +  ++   + Q  +    Q     + + +AI +  + +  L+        
Sbjct: 2439 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ------- 2491

Query: 2669 LDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEE 2724
             + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E
Sbjct: 2492 -EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2550

Query: 2725 YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQN 2784
              KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ 
Sbjct: 2551 VAKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRR 2608

Query: 2785 KSHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
            +   + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2609 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660



 Score =  565 bits (1457), Expect = e-160
 Identities = 273/462 (59%), Positives = 365/462 (79%), Gaps = 1/462 (0%)

Query: 19  LQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSG 78
           L   E  + R  DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSG
Sbjct: 53  LDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSG 112

Query: 79  DTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQ 138
           D+LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQ
Sbjct: 113 DSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQ 172

Query: 139 ISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 198
           ISDI V+G+SEDM+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LI
Sbjct: 173 ISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 232

Query: 199 DMNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKV 257
           DMN V  Q+NL NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+V
Sbjct: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292

Query: 258 PEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFK 317
           P+  +G+ AN+++++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FK
Sbjct: 293 PDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 352

Query: 318 ETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALR 377
           E E+P KE +K++ K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR
Sbjct: 353 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR 412

Query: 378 PEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILEC 437
            E ERLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + 
Sbjct: 413 SEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKA 472

Query: 438 ENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 479
           ++++R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 473 DSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 514



 Score =  111 bits (277), Expect = 2e-23
 Identities = 355/1874 (18%), Positives = 725/1874 (38%), Gaps = 306/1874 (16%)

Query: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 986  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1045

Query: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1105

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 1106 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1157

Query: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 1158 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1214

Query: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFC--LDPAEGENS 2907
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274

Query: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1307

Query: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 1308 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1366

Query: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQG 3086
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1425

Query: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 1426 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477

Query: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1526

Query: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264
            +         +  +ESQ     E E  ++         K E E  + KQ+ +  L +  +
Sbjct: 1527 RR--------QVQDESQRKRQAEVELASRV--------KAEAEAAREKQRALQALEELRL 1570

Query: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
            Q+                     + L +   +RA Q+Q AL                   
Sbjct: 1571 QAEEAE-----------------RRLRQAEVERARQVQVAL------------------- 1594

Query: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
                   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 1595 ----ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1650

Query: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443
            +   +  L   RW+   N+A     Q E    VAQQ     + L +     EK+    E 
Sbjct: 1651 REEAEREL--ERWQLKANEALRLRLQAEE---VAQQ-----KSLAQ--AEAEKQKEEAER 1698

Query: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMNWLN--EVHDKLSKLSVQDYST 3557
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818

Query: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAIG- 1870

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 1871 ---EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1923

Query: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 1924 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1971

Query: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 1972 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2024

Query: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLE- 3847
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ E 
Sbjct: 2025 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2078

Query: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907
            +A +   Q  E  +EL   L + QS++ QL   A   E  R+  EE  + R         
Sbjct: 2079 KAHAFAVQQKE--QELQQTLQQEQSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2133

Query: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQST----- 3962
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE 2193

Query: 3963 -QFHDK-----------IDQILESLE-RIVERLRQPPSISAEVEKIKEQISENK------ 4003
             + H K           ++Q L +L  ++ E   Q   +  E++++K + +E        
Sbjct: 2194 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV 2253

Query: 4004 -----NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHT 4058
                 +V V ME+L  L   ++     +I R    DKD + + +Q++ ++M  + E    
Sbjct: 2254 EEELFSVRVQMEELSKLKARIEAENRALILR----DKDNTQRFLQEEAEKMKQVAEEAAR 2309

Query: 4059 L-VEEREAKLLDVMELAEKFWCDHMSLIVT-IKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
            L V  +EA  L   +LAE+      +L    +K+    +++      +  +++QQ+E A+
Sbjct: 2310 LSVAAQEAARL--RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367

Query: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176
               E+   LQE+ +       ++     E  +   +    E     +   +A + ++ ++
Sbjct: 2368 ---EQARRLQEDKE-------QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKL-RV 2416

Query: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQI 4236
             E  +A  + ++  Q      +  G KL        +  T+ Q +E             I
Sbjct: 2417 AEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE-------------I 2463

Query: 4237 EMERLNHQAELLLKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQ 4295
            + ++ +H AE L + + E E +K  +Q    E KL+    EE    +Q +L     AL Q
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQ---EAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520

Query: 4296 FQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI----ELAKHHVLQNDVLAHQSTVEAV 4351
                     ++L+  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E  
Sbjct: 2521 ---------SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2571

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
             +    L+ S   EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +
Sbjct: 2572 RQR---LVASM--EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLRE 2623

Query: 4412 LQQWLTDTERHLLA 4425
              Q L +  R  LA
Sbjct: 2624 QLQLLEEQHRAALA 2637



 Score = 94.0 bits (232), Expect = 4e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 977  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1030

Query: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 1031 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1082

Query: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 1083 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1142

Query: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 1143 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1202

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 1203 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1260

Query: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320

Query: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 1321 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1379

Query: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 1380 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1423

Query: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 1424 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1477

Query: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537

Query: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 1538 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1586

Query: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 1587 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1622

Query: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 1623 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1664

Query: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1723

Query: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 1724 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1777

Query: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1832

Query: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 1833 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888

Query: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 1889 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947

Query: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007

Query: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067

Query: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2118

Query: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 2119 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2178

Query: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 2179 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2232

Query: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 2233 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2288

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 2289 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2337

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 2338 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397

Query: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 2398 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454

Query: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2512

Query: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 2513 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569

Query: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2613

Query: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 2614 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2650



 Score = 85.1 bits (209), Expect = 2e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 1153 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1207

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 1208 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264

Query: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324

Query: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 1325 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1370

Query: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430

Query: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 1431 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1482

Query: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 1483 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1535

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 1536 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1585

Query: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 1586 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 1641 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1693

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753

Query: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1807

Query: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867

Query: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 1868 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1916

Query: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 1917 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1967

Query: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 1968 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023

Query: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 2024 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2068

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 2069 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121

Query: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 2122 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173

Query: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2284

Query: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2336

Query: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 2337 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2391

Query: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 2392 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2444

Query: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 2445 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496

Query: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2537



 Score = 78.6 bits (192), Expect = 2e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 539  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 591

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 592  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 647

Query: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 648  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 701

Query: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 702  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 740

Query: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 741  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 789

Query: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 790  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 837

Query: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 838  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 891

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 892  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 946

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 947  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 990

Query: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 991  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1039

Query: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1099

Query: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 1100 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1155

Query: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 1156 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1213

Query: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273

Query: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 1274 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1333

Query: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393

Query: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452

Query: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 1453 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1503

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1562

Query: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 1563 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620

Query: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1660

Query: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720

Query: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 1721 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776

Query: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 1777 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1836

Query: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 1837 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1890

Query: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 1891 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1949

Query: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 1950 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2009

Query: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2069

Query: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 2070 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122

Query: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2177

Query: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 2178 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2236

Query: 5067 QQVWLLALERRRKLNDALDRLEELR 5091
            Q++   A E  R+ +   + L  +R
Sbjct: 2237 QRLKAEATEAARQRSQVEEELFSVR 2261



 Score = 69.3 bits (168), Expect = 1e-10
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1096

Query: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 1097 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1152

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 1153 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1212

Query: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 1213 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1271

Query: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 1272 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1312

Query: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 1313 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1372

Query: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 1373 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1432

Query: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 1433 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1488

Query: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 1489 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1544

Query: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1602

Query: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 1603 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1662

Query: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 1663 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718

Query: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1777

Query: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1830

Query: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 1831 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1880

Query: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 1881 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1919

Query: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 1920 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1978

Query: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015



 Score = 40.0 bits (92), Expect = 0.064
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250

Query: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310

Query: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 2311 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2367

Query: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 2368 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2427

Query: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487

Query: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547

Query: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 2548 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604

Query: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2664

Query: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501
            ++ +        +++  ++ LQ   +  A+
Sbjct: 2665 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2694



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)

Query: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 391  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 450

Query: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 451  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 510

Query: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 511  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 562

Query: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 563  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 622

Query: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4861
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+    
Sbjct: 623  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 667

Query: 4862 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909
                 D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 668  GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 715



 Score = 35.0 bits (79), Expect = 2.1
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 4484 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4534


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score =  667 bits (1721), Expect = 0.0
 Identities = 314/717 (43%), Positives = 503/717 (70%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF++ ++ A+ 
Sbjct: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RK SCDRS+++
Sbjct: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+E  +   R+E Q+Q
Sbjct: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130

Query: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250

Query: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ 1317
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ
Sbjct: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367



 Score =  560 bits (1444), Expect = e-158
 Identities = 269/450 (59%), Positives = 360/450 (80%), Gaps = 1/450 (0%)

Query: 31  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 90
           DERD+VQKKT TKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF
Sbjct: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230

Query: 91  HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 150
           H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED
Sbjct: 231 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290

Query: 151 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 210
           M+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V  Q+NL 
Sbjct: 291 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350

Query: 211 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 269
           NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP+  +G+ AN++
Sbjct: 351 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410

Query: 270 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 329
           +++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE E+P KE +K+
Sbjct: 411 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470

Query: 330 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 389
           + K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I
Sbjct: 471 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530

Query: 390 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 449
             ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++R    DVQ
Sbjct: 531 VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590

Query: 450 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 479
            L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 591 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 620



 Score = 44.7 bits (104), Expect = 0.003
 Identities = 154/796 (19%), Positives = 310/796 (38%), Gaps = 129/796 (16%)

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 645  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 697

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 698  IEEFQAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753

Query: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 754  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 807

Query: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 808  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 846

Query: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 847  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKNSCDRSATVTRLED 895

Query: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 896  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 943

Query: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 944  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 997

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 998  VQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1052

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 1053 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1096

Query: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 1097 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1145

Query: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1205

Query: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 1206 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1261

Query: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 1262 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1319

Query: 4052 IWENIHTLVEEREAKL 4067
             W+ +    + R+ +L
Sbjct: 1320 RWQAVLAQTDVRQREL 1335



 Score = 41.6 bits (96), Expect = 0.022
 Identities = 60/296 (20%), Positives = 122/296 (41%), Gaps = 35/296 (11%)

Query: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 1083 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1136

Query: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 1137 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1188

Query: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 1189 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1248

Query: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 1249 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1308

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKR 3437
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R
Sbjct: 1309 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1362



 Score = 40.4 bits (93), Expect = 0.049
 Identities = 56/223 (25%), Positives = 95/223 (42%), Gaps = 26/223 (11%)

Query: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 1146 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1202

Query: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 1203 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1258

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 1259 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1318

Query: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R
Sbjct: 1319 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1361



 Score = 38.9 bits (89), Expect = 0.14
 Identities = 33/147 (22%), Positives = 67/147 (45%), Gaps = 5/147 (3%)

Query: 2411 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT-ATKWQQTPAPTDTEAVKTQV 2469
            L  +  +K+  ++  +   Q A+E   A  + L++     AT  +        + ++ Q 
Sbjct: 1213 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1272

Query: 2470 E-QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2528
            E Q  +F+A L+  +   QE+ ++L +   E     E  RW++ + ++  +WQ +   T 
Sbjct: 1273 EAQQPTFDA-LRDELRGAQEVGERLQQRHGERD--VEVERWRERVAQLLERWQAVLAQTD 1329

Query: 2529 DRQQKLEESSNNLTQFQTVEAQLKQWL 2555
             RQ++LE+    L  ++     L  WL
Sbjct: 1330 VRQRELEQLGRQLRYYRESADPLGAWL 1356



 Score = 35.4 bits (80), Expect = 1.6
 Identities = 73/348 (20%), Positives = 135/348 (38%), Gaps = 54/348 (15%)

Query: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 497  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDI 556

Query: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 557  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 616

Query: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 617  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 668

Query: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 669  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLG 728

Query: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQTLRF 4861
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+    
Sbjct: 729  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEE-EV 773

Query: 4862 HGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909
                 D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 774  GFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 821



 Score = 34.7 bits (78), Expect = 2.7
 Identities = 77/390 (19%), Positives = 150/390 (38%), Gaps = 56/390 (14%)

Query: 2545 QTVEAQLKQWLVEKELMVSVLGPLSIDPNML---NTQRQQVQIL----LQEFATRKPQYE 2597
            Q V+  + +   + + +V++   L +D   L    + R+ VQ++    L  F T KP+ +
Sbjct: 996  QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1055

Query: 2598 Q-----LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2652
            +     L    Q  L R  +D    G   E      +++    G  S     + Q++ + 
Sbjct: 1056 RQALHSLELHYQAFL-RDSQDAG--GFGPEDRLMAEREY----GSCSHHYQQLLQSLEQG 1108

Query: 2653 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI-QQEKKQIKVA- 2710
             Q +S  +    +L D+  +L +    + H   +    E A++  Q I +Q+K Q +V  
Sbjct: 1109 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1168

Query: 2711 --------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASS 2762
                     A  E + AL +       L  +LE  L   + V   +  +++ L++     
Sbjct: 1169 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1228

Query: 2763 HQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIA 2822
               Q      +A  +  KE Q     + A L  LE+     K   K L AQ+   + T  
Sbjct: 1229 RGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KASLKKLRAQAEAQQPTF- 1279

Query: 2823 EGENLLLKTQGSEKAALQLQ----------------LNTIKTNWDTFNKQVKERENKLKE 2866
              + L  + +G+++   +LQ                +  +   W     Q   R+ +L++
Sbjct: 1280 --DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1337

Query: 2867 SLEKALKYKEQVETLWPWIDKCQNNLEEIK 2896
               +   Y+E  + L  W+   +   E+I+
Sbjct: 1338 LGRQLRYYRESADPLGAWLQDARRRQEQIQ 1367


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score =  609 bits (1571), Expect = e-173
 Identities = 460/1803 (25%), Positives = 884/1803 (49%), Gaps = 168/1803 (9%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1052
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651

Query: 1053 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1111
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711

Query: 1112 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1171
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767

Query: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1231
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827

Query: 1232 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1291
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887

Query: 1292 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1351
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947

Query: 1352 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1411
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007

Query: 1412 TLMTQYIKFAGDSLKRLE------------EEE---------------KSLEEEKKEHVE 1444
            T    Y +F  + LK LE            EEE               K L++  +++  
Sbjct: 1008 TRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA 1067

Query: 1445 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISS-----EEISTKKEQLSEALQTIQLFL 1499
            +  + +  ++++ +  + AE  GK   +KQ +       +E++ K  +L+  ++  +   
Sbjct: 1068 ECSQFKAKLASLEELKRQAELDGKS--AKQNLDKCYGQIKELNEKITRLTYEIED-EKRR 1124

Query: 1500 AKHGDKMTDEERNELEKQVKTLQ-ESYNLLFS--ESLKQLQESQTSGD-VKVEEKIVAER 1555
             K  +   D+++N+ ++  K  Q E  NL +   ES K ++E +   + ++V  +    R
Sbjct: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184

Query: 1556 QQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALA 1615
            ++EY+ +L  + +   +  + L    E   I      +K+   ++E+  K+++     L+
Sbjct: 1185 KREYENELAKVRNHYNEEMSNLRNKYET-EINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243

Query: 1616 --------EVVKNTENFLKENGEKLSQEDKAL--------IEQKLNEAKIKCEQL----- 1654
                    E+V+  ++ L+   ++   E+ AL        I QK    +I+ +Q+     
Sbjct: 1244 RENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRS 1303

Query: 1655 --NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1712
              N + +QS +E  K +    KE     A  ++  + + + EN L  + N + D E    
Sbjct: 1304 EDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN-NYDEEIISL 1362

Query: 1713 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN--LNQQYQKVK-- 1768
            K++   E N T  +    +  + +E++ +G   + D       T+EN  L+++ +++K  
Sbjct: 1363 KNQFETEINIT--KTTIHQLTMQKEEDTSGYRAQID-----NLTRENRSLSEEIKRLKNT 1415

Query: 1769 -AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEK 1827
              Q  + + + +  I   ++    + ++ Q L  E ++  Q   +E  V Y+ +L ++ K
Sbjct: 1416 LTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEE-SVRYKQSLDDAAK 1474

Query: 1828 KMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDV 1887
             ++  +   E L++     T     L+     L+ ++      N   T+   +    E  
Sbjct: 1475 TIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQ- 1533

Query: 1888 ISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQR-KLDHATDRFRSLYSKC 1946
                 +L  + I   RV +  ++   +D  +   S    ++Q+ K++   +R +   S+ 
Sbjct: 1534 -----ELTRLRIDYERVSQ-ERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASED 1587

Query: 1947 NVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQLEETK 2004
            +     L++ ++          G+   L  QA + T      E  ++  K  +  L + +
Sbjct: 1588 SCKRKKLEEELE----------GMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQR 1637

Query: 2005 -ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT---LDDIVGRYEDLSKSVN 2060
              L G +  +Q   E+L++ +  +   R  LL  +  +++     +      ED S+S+N
Sbjct: 1638 DVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLN 1697

Query: 2061 ERN---EKLQITLTRSLSVQD-GLDEMLDWMGNVESSL---KEQGQVPLNSTAL----QD 2109
            E     E+LQ +LT +L+ +   L+E L  +      L   + +     N+T L    Q 
Sbjct: 1698 ESKIEIERLQ-SLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL 1756

Query: 2110 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2169
             IS N  LE  + G  + +    E +++ +E          Q +  + S R  E+ ++  
Sbjct: 1757 QISNNRTLE--LQGLINDLQRERENLRQEIE--------KFQKQALEASNRIQESKNQCT 1806

Query: 2170 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2229
            + + + E L  K+++ E    +LQ   +   +A + ++   +    L    Q+  ++  +
Sbjct: 1807 QVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQ 1866

Query: 2230 HKKHLEVLHSLLKEISSHGLPS--DKALVLEKTNNLSKKFKEMEDTIKEKKEAVT-SCQE 2286
             K         +++I S    S  +K  +  +   L  + K +E+  + K E  T   Q 
Sbjct: 1867 WKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQS 1926

Query: 2287 QLD 2289
            QL+
Sbjct: 1927 QLE 1929



 Score = 90.5 bits (223), Expect = 4e-17
 Identities = 231/1243 (18%), Positives = 489/1243 (39%), Gaps = 199/1243 (16%)

Query: 3265 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3315
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895

Query: 3316 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3374
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955

Query: 3375 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3427
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010

Query: 3428 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3484
             ++   + + L + E +    T+   LEE++   +    +  N NK L            
Sbjct: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFL------------ 1058

Query: 3485 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3544
                 D+++ + + + SQ      + K  S  EL +QA  + K   ++  +    + E++
Sbjct: 1059 -----DQNLQKYQAECSQ-----FKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108

Query: 3545 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3604
            +K+++L+   Y  E     +   R   ED   +++N    L    +  K+  G + L   
Sbjct: 1109 EKITRLT---YEIE----DEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKL--- 1158

Query: 3605 DKLEAIKARYKDITK----LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3660
            +  +AIK +  +I +    L  +  +  E   +LA+  +  +EE+    +K E E+   +
Sbjct: 1159 ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK 1218

Query: 3661 TQV--LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAE 3718
            T +  +  ++   ++    +L + ++ N+ L D +  ++ ++L+    R R       AE
Sbjct: 1219 TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRR-------AE 1271

Query: 3719 DNE-RYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQ 3777
            +N  + +     I QK + ++  +   Q   Q ++         E+   ++ D   E ++
Sbjct: 1272 ENALQQKACGSEIMQKKQHLEIEL--KQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIER 1329

Query: 3778 TSAQLQ---------------VQKTFTMEILRHKDIID---DLVKSGHKIMTACSEEEKQ 3819
              A+ Q               V+  +  EI+  K+  +   ++ K+    +T   EE+  
Sbjct: 1330 LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389

Query: 3820 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3879
              + ++D + +   ++ +       +++R ++ + Q  E        L   +  I Q  A
Sbjct: 1390 GYRAQIDNLTRENRSLSE-------EIKRLKNTLTQTTEN-------LRRVEEDIQQQKA 1435

Query: 3880 PALEYETLRQQQE-EHRQLRELIAE----HKPHIDKMNKTGPQLLELSPGEGFSIQEKYV 3934
               E    +QQ E E RQ+ ++  E    +K  +D   KT              IQ+K  
Sbjct: 1436 TGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKT--------------IQDKNK 1481

Query: 3935 AADTLYSQIKEDVKKRAVALDE-AISQSTQFHDKIDQILESLERIVERLRQPPSISAEVE 3993
              + L   I ++   R    DE A  Q  Q+   + +   S    + +L+        + 
Sbjct: 1482 EIERLKQLIDKETNDRKCLEDENARLQRVQY--DLQKANSSATETINKLKVQEQELTRLR 1539

Query: 3994 KIKEQISENKNV-SVDMEKLQPLYETL---KQRGEEMIARSGGTDKDISAKAVQDKLDQM 4049
               E++S+ + V   D+ + Q   + L   KQ+ EE + R   T  + S K  + KL++ 
Sbjct: 1540 IDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCK--RKKLEEE 1597

Query: 4050 VFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVK 4109
            +   E +   ++E+  K+ ++ +  E+         +  K ++D +R   D  +D  + +
Sbjct: 1598 L---EGMRRSLKEQAIKITNLTQQLEQ-------ASIVKKRSEDDLRQQRDV-LDGHLRE 1646

Query: 4110 QQ--QEAAETIREEIDGLQEEL----DIV--INLGSELIAACGEPDKPIVKKSIDELNSA 4161
            +Q  QE    +  E++ L+ +L    + V   +L +E      E     + +S  E+   
Sbjct: 1647 KQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERL 1706

Query: 4162 WDSLNKAWKDRIDKLEEAMQAAVQYQD--------------GLQAVFDWVDIAGGKLASM 4207
                    K+ +   EE     ++Y D               +  +   + I+  +   +
Sbjct: 1707 QSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLEL 1766

Query: 4208 SPIGTDLETVKQQI-EELKQFKSEAYQQQIEMERLNHQA--------ELLLKKVTEESDK 4258
              +  DL+  ++ + +E+++F+ +A +    ++   +Q          LL+K    E DK
Sbjct: 1767 QGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDK 1826

Query: 4259 HTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQK 4318
              +Q    EL     +LE     +Q +LE       + Q   ++L  W T         +
Sbjct: 1827 ARLQRLEDELNRAKSTLEAETRVKQ-RLE------CEKQQIQNDLNQWKTQYSRKEEAIR 1879

Query: 4319 PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLN 4378
             +  + +  E E    + L++++   Q+ ++ + +     +E S  E     Q++LE   
Sbjct: 1880 KIESEREKSERE---KNSLRSEIERLQAEIKRIEERCRRKLEDSTRE----TQSQLETER 1932

Query: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421
             R+Q  ++K  QR            G H E +   +W  DT +
Sbjct: 1933 SRYQREIDKLRQRPY----------GSHRETQTECEWTVDTSK 1965



 Score = 70.9 bits (172), Expect = 3e-11
 Identities = 245/1257 (19%), Positives = 493/1257 (39%), Gaps = 214/1257 (17%)

Query: 2393 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMM--------QWLQ 2444
            GL  IK D+            L K  +A + T+L K Q+   ++S           ++ +
Sbjct: 810  GLKKIKNDLN-----------LKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGE 858

Query: 2445 KMNKTATKWQQTPAPTDTEA--VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN-P 2501
            K+ +   +WQ+     D     ++ Q++Q +++    +     + + K +   L      
Sbjct: 859  KVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFG 918

Query: 2502 DTPEAPRW----KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVE 2557
            D+    R+    K + +EI  K  +  ++     QK+ E   N    +  E QL  +   
Sbjct: 919  DSNTVMRFLNEQKNLHSEISGKRDKSEEV-----QKIAELCAN--SIKDYELQLASYTSG 971

Query: 2558 KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQY-EQLTAAGQ-----GILSRPG 2611
             E ++++       P      +    ++LQE A    +Y E LT +G        + +  
Sbjct: 972  LETLLNI-------PIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSL 1024

Query: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVK----STQYQSLLRSLSD--K 2665
            ED  L+    E L    +       +  ++  ++DQ + K     +Q+++ L SL +  +
Sbjct: 1025 EDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKR 1084

Query: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2725
             ++LD K S+   +      + +  E   ++  EI+ EK++ K      ED     K +Y
Sbjct: 1085 QAELDGK-SAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSV----EDRFDQQKNDY 1139

Query: 2726 LKAELSRQLEGI------LKSFKDVEQKAENHVQHL----------------QSACASSH 2763
             + + +RQ E        L+S K +++K E  ++ L                + A   +H
Sbjct: 1140 DQLQKARQCEKENLGWQKLESEKAIKEK-EYEIERLRVLLQEEGTRKREYENELAKVRNH 1198

Query: 2764 QFQQMSR---DFQAWLDTKK--------EEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2812
              ++MS     ++  ++  K        ++++ S  +  +LD L    +D KD    L  
Sbjct: 1199 YNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLND 1258

Query: 2813 Q--SHMYEKTIAEGENLLLKTQGSE----KAALQLQLNTIKTNWDTFNKQVKER------ 2860
                   ++  AE   L  K  GSE    K  L+++L  +       N + K+       
Sbjct: 1259 SILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAK 1318

Query: 2861 --ENKLKESLEKALKYKEQVETLWPW---IDKCQNNL-EEIKFCLDPAEGENSIAKLK-- 2912
              ++K KE      +++E+ +  W +   + K +NN  EEI    +  E E +I K    
Sbjct: 1319 TIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIH 1378

Query: 2913 --SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFC 2970
              ++QKE D      ++ N                +T EN+SL +++  +   L      
Sbjct: 1379 QLTMQKEEDTSGYRAQIDN----------------LTRENRSLSEEIKRLKNTLTQTT-- 1420

Query: 2971 LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3030
             EN+ +  ++ Q+  K +  ++   K+QL++     +Q  + + +   Q+   + + ++ 
Sbjct: 1421 -ENLRRVEEDIQQ-QKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQD 1478

Query: 3031 QVDLAKRLAQDLVVEASDSKGTSDVLLQVETI-------------------AQEHSTLSQ 3071
            +    +RL Q +  E +D K   D   +++ +                    QE      
Sbjct: 1479 KNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRL 1538

Query: 3072 QVD-EKCSFLET-KLQGIGHFQNTIREMFSQFAEFDDELDSM-APVGRDAETLQKQKETI 3128
            ++D E+ S   T K Q I  FQN+++E+  Q  + ++EL+ +      D+   +K +E +
Sbjct: 1539 RIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEEL 1598

Query: 3129 KAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRD---------------LEALS 3173
            +   + L+       N  +  +     ++ S D +  +RD               L  LS
Sbjct: 1599 EGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658

Query: 3174 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEE---------SQGPV 3224
             +   L  +    +E V+    R E F   +++ S  L +++   E         ++  +
Sbjct: 1659 SEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHL 1718

Query: 3225 GMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDL---- 3280
             +E E  N +L  +   ++   E    K   +  L   L  S  ++   QGL +DL    
Sbjct: 1719 MLEEELRNLRLE-YDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER 1777

Query: 3281 DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFK 3340
            +++    +   K+  + + ++QE+   C +     ESLL                  + K
Sbjct: 1778 ENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLL-----------------VKIK 1820

Query: 3341 VVKAQIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3397
            V++   Q++  LQRL D+    KST+E   R  +++    E       L Q     SR E
Sbjct: 1821 VLE---QDKARLQRLEDELNRAKSTLEAETRVKQRL--ECEKQQIQNDLNQWKTQYSRKE 1875

Query: 3398 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ--ASKLEEQI 3455
              + K E+   + E            +E L   +  IE+R        T+   S+LE + 
Sbjct: 1876 EAIRKIESEREKSER---EKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETER 1932

Query: 3456 AQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKS 3512
            ++++   D +       H+         V +S+   D ++ K+   Q++  ++ +K+
Sbjct: 1933 SRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT 1989



 Score = 70.1 bits (170), Expect = 6e-11
 Identities = 302/1685 (17%), Positives = 650/1685 (38%), Gaps = 262/1685 (15%)

Query: 1050 ELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERD-DLHESVFRITE 1108
            ++ K  +   +E + Y  +  E ++    L+  +D + ++   P +++  L   + +I E
Sbjct: 363  QITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKY--PCDKNMPLQHLLEQIKE 420

Query: 1109 QEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNM----------- 1157
             EK ++++   K  +  + NK ++       +   P  RS   ++L+ +           
Sbjct: 421  LEKEREKILEYKRQVQNLVNKSKKIVQLKPRN---PDYRSNKPIILRALCDYKQDQKIVH 477

Query: 1158 -------------NQVYSMSSTYIDKL-KTVNLVLK--NTQAAEALVKLYETKLCEEEAV 1201
                         ++ Y      +D L  +V L++   N  A +   K+ +      EA+
Sbjct: 478  KGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYY----EAI 533

Query: 1202 IADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDL-----D 1256
            +A  N +   + +L  W           H    +++K +A++    KT ++ D      D
Sbjct: 534  LALWNQLYINMKSLVSW-----------HYCMIDIEKIRAMTIAKLKTMRQEDYMKTIAD 582

Query: 1257 FDWHKEKADQLVERWQNVHVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQQ--VETTQ 1313
             + H +   + +   Q   +  D+  R ++     + K+Y+     L  + Q   V TT+
Sbjct: 583  LELHYQ---EFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTE 639

Query: 1314 ------------RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD-ECQKYAEQYSA 1360
                         K+ E   EN K     L + + +  +IE  + +M  +    A+Q S+
Sbjct: 640  ITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSS 699

Query: 1361 ---TVKDYELQTMTYR----AMVDSQQKSPVKRRR-------MQSSADLIIQEFMDLR-- 1404
               TVK  EL+++       A V +Q K  +   R       +Q+    + Q+  ++   
Sbjct: 700  HHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759

Query: 1405 ----TRYTALVTLMTQYIKFAGDSLK----RLEEEEK-SLEEEKKEHVEKAKELQKWVSN 1455
                      V  + Q I    D LK    RL EEE   L+ +K E      +  K   N
Sbjct: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLN 819

Query: 1456 ISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTD--EERNE 1513
            + K+L           +  K   ++      Q S+      L L K G+K+T   +    
Sbjct: 820  LKKSL----------LATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQR 869

Query: 1514 LEKQVKTLQESYNLL-FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
            ++KQ+      + L    + +KQL+                     Y++  Q  C  L  
Sbjct: 870  IDKQI-----DFRLWDLEKQIKQLRN--------------------YRDNYQAFCKWLYD 904

Query: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTE---NFLKENG 1629
             + R     E+   GD    ++ + ++Q+ L  ++ G      EV K  E   N +K+  
Sbjct: 905  AKRRQ-DSLESMKFGDSNTVMR-FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYE 962

Query: 1630 EKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEET----------EK 1679
             +L+     L  + L    IK   +   +    +E   V    I+  T          E 
Sbjct: 963  LQLASYTSGL--ETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEM 1020

Query: 1680 VAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE--GDGKSAIGEE 1737
            + +++ L+   TKIE L + L  + +D+        + ++QN   +Q      K+ +   
Sbjct: 1021 LKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASL 1079

Query: 1738 DEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQ 1797
            +E+     + ++DG+  + ++NL++ Y ++K  +EKI      +    +  + + ++  Q
Sbjct: 1080 EELKR---QAELDGK--SAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQ 1134

Query: 1798 YLSPEEKEKLQK-------NMKELKVHYETALAESEKKM-KLTHSLQEELEKFDADYTEF 1849
                 + ++LQK       N+   K+  E A+ E E ++ +L   LQEE  +      E 
Sbjct: 1135 --QKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENEL 1192

Query: 1850 EHWLQQSEQELENLEAGAD-DINGLMTKLKRQKSFSED-----------VISHKGDLR-Y 1896
                    +E+ NL    + +IN   T +K      ED           +     DL+  
Sbjct: 1193 AKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDE 1252

Query: 1897 ITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDL 1956
            I    + +L+A +   + +   +   A   E+ +K  H     +       V+    +D 
Sbjct: 1253 IVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQ------VMQQRSEDN 1306

Query: 1957 VDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVA 2016
                Q  E+A+  +           +K +    A   +  +R+ E    L    ++    
Sbjct: 1307 ARHKQSLEEAAKTI--------QDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEE 1358

Query: 2017 VEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI-----VGRYEDLSKSVNERNEKLQITLT 2071
            +  LK   E  ++   + +     +QK  D       +      ++S++E  ++L+ TLT
Sbjct: 1359 IISLKNQFETEINITKTTIHQLT-MQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLT 1417

Query: 2072 RSLSVQDGLDEMLDWM---GNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2128
            ++      ++E +      G+  S  K+Q +V L     Q    +++  +Q +     +I
Sbjct: 1418 QTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVT-QMRTEESVRYKQSLDDAAKTI 1476

Query: 2129 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL 2188
               N+++++  +  D  T    +  ++D +AR     +  ++  +   E   K+++ E  
Sbjct: 1477 QDKNKEIERLKQLIDKETND--RKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQE 1534

Query: 2189 SEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHG 2248
              +L+   E  +Q  T  D   +D+T     ++E     L+ +K  E L+ L +  S   
Sbjct: 1535 LTRLRIDYERVSQERTVKD---QDITRFQNSLKELQ---LQKQKVEEELNRLKRTASEDS 1588

Query: 2249 LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKK 2308
                      K   L ++ + M  ++KE+   +T+  +QL+   ++ K  +  +++    
Sbjct: 1589 C---------KRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDV 1639

Query: 2309 VP--IVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAI 2366
            +   + +     E+L +   + + L+ +      E + V  + +   +   A+   ++++
Sbjct: 1640 LDGHLREKQRTQEELRRLSSEVEALRRQ---LLQEQESVKQAHLRNEHFQKAIEDKSRSL 1696

Query: 2367 AAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLG-------LLLKDKI 2419
               K     L         E     + L +++ +  D+  G  +         L L+ ++
Sbjct: 1697 NESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQL 1756

Query: 2420 AELNTKLSKLQ----KAQEESSAMMQWLQKMNKTA---------TKWQQTPAPTDTEAVK 2466
               N +  +LQ      Q E   + Q ++K  K A         +K Q T    + E++ 
Sbjct: 1757 QISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLL 1816

Query: 2467 TQV---EQNKSFEAELKQNVNKVQELKDKLTEL-----LEENPDTPEAPRWKQMLTEIDS 2518
             ++   EQ+K+    L+  +N+ +   +  T +      E+     +  +WK   T+   
Sbjct: 1817 VKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWK---TQYSR 1873

Query: 2519 KWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQ 2578
            K + + ++  +R++   E ++  ++ + ++A++K+  +E+     +        + L T+
Sbjct: 1874 KEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR--IEERCRRKLEDSTRETQSQLETE 1931

Query: 2579 RQQVQ 2583
            R + Q
Sbjct: 1932 RSRYQ 1936



 Score = 66.6 bits (161), Expect = 6e-10
 Identities = 234/1283 (18%), Positives = 498/1283 (38%), Gaps = 200/1283 (15%)

Query: 3579 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3633
            QN  QA+   L  LK         ++   +Q+++  +  + ++I  ++     +L     
Sbjct: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772

Query: 3634 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3693
            L + +  T + L  +    E  L   ET  L  ++    +   K++K +    K+LL ++
Sbjct: 773  LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828

Query: 3694 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3744
                    ++ S   +  P    +     + V +  +R++ +   I  ++ +++  I + 
Sbjct: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888

Query: 3745 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3803
            + +     A   W+ + +++  SL  ++     T  + L  QK    EI   +D  +++ 
Sbjct: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948

Query: 3804 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3861
            K       +  + E Q  S    L+ +L        I S   + L+ A  +  ++ E   
Sbjct: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008

Query: 3862 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3921
                +      ++  L    L+   +   +EE R  R+  +E+       NK   Q L+ 
Sbjct: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064

Query: 3922 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE----- 3976
               E    + K  + + L  Q + D K     LD+   Q  + ++KI ++   +E     
Sbjct: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRR 1124

Query: 3977 --RIVERLRQPPSISAEVEKIKEQISEN------------KNVSVDMEKLQPLYE---TL 4019
               + +R  Q  +   +++K ++   EN            K    ++E+L+ L +   T 
Sbjct: 1125 RKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTR 1184

Query: 4020 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN----IHTLVEEREAKLLDVMELAE 4075
            K+  E  +A+      +  +  +++K +  + I +     I    E+    L + ++   
Sbjct: 1185 KREYENELAKVRNHYNEEMSN-LRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLS 1243

Query: 4076 KFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL 4135
            +   D    IV + D+   ++  E          QQ+     I ++   L+ EL  V+  
Sbjct: 1244 RENRDLKDEIVRLNDS--ILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQ 1301

Query: 4136 GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFD 4195
             SE        D    K+S++E        NK  +    + +E  +   +Y++ L  V +
Sbjct: 1302 RSE--------DNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRN 1353

Query: 4196 WVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSE---AYQQQIE-MERLNHQAELLLKK 4251
              D     ++  +   T++   K  I +L   K E    Y+ QI+ + R N      +K+
Sbjct: 1354 NYDEE--IISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKR 1411

Query: 4252 VTEESDKHTVQDPLMELKLIWDSLEER------IINRQHKLEGALLALGQ--------FQ 4297
            +     K+T+      L+ + + ++++      +  R+ +LE  L  + Q        ++
Sbjct: 1412 L-----KNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYK 1466

Query: 4298 HALDELLAWLTHTEGLLSEQKPV----GGDPKAIEIELAKHHVLQNDVL-AHQSTVEAVN 4352
             +LD+    +      +   K +      D K +E E A+   +Q D+  A+ S  E +N
Sbjct: 1467 QSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETIN 1526

Query: 4353 KAGNDLIESSAGEEASNLQNKLEVLNQ----------RWQNVLEKTEQRKQQLDGALRQA 4402
            K           +E + L+   E ++Q          R+QN L++ + +KQ+++  L + 
Sbjct: 1527 KL------KVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRL 1580

Query: 4403 KGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL----NVHMEVCAAFEAKEETYK 4458
            K    E         D+ +     + L G+  + KEQ     N+  ++  A   K+ +  
Sbjct: 1581 KRTASE---------DSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED 1631

Query: 4459 SLMQ-------------KGQQMLARCPKSAET---------------------------N 4478
             L Q             + Q+ L R     E                            +
Sbjct: 1632 DLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED 1691

Query: 4479 IDQDINNLK---EKWESVETKLNERKTKLEEAL-NLAMEFHNSLQ-------DFINWLTQ 4527
              + +N  K   E+ +S+   L +    LEE L NL +E+ +  +       D    + +
Sbjct: 1692 KSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILE 1751

Query: 4528 AEQTLNVASRPSLILDTVLFQID-EHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVV 4586
                L +++  +L L  ++  +  E +    E+   ++Q +E        K  +Q   VV
Sbjct: 1752 LRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESK--NQCTQVV 1809

Query: 4587 LIK-NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4645
              + +LL+ +     KV+++   R + L+D   RAK   EA +++ + LE  ++      
Sbjct: 1810 QERESLLVKI-----KVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQ------ 1858

Query: 4646 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4705
            +I ND ++ KTQ ++ +E  + + ++           +S +EK SL  +  +L   +  +
Sbjct: 1859 QIQNDLNQWKTQYSRKEEAIRKIESERE---------KSEREKNSLRSEIERLQAEIKRI 1909

Query: 4706 RDKWDTICGKSVERQNKLEEALL 4728
             ++    C + +E   +  ++ L
Sbjct: 1910 EER----CRRKLEDSTRETQSQL 1928



 Score = 52.4 bits (124), Expect = 1e-05
 Identities = 186/959 (19%), Positives = 361/959 (37%), Gaps = 164/959 (17%)

Query: 3967 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729

Query: 4027 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4086
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775

Query: 4087 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4137
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835

Query: 4138 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4190
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895

Query: 4191 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4249
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954

Query: 4250 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4303
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006

Query: 4304 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4362
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061

Query: 4363 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4419
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121

Query: 4420 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4479
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160

Query: 4480 DQDINNLKEKWESVETKLNERKTKLEEALN-LAMEFHNSLQDFINWLTQAEQTLNVASRP 4538
            ++ I   + + E +   L E  T+  E  N LA   ++  ++  N   + E  +N+    
Sbjct: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK-- 1218

Query: 4539 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4598
                 T + +I   K   ++  + R Q+  L +    L     K ++V +          
Sbjct: 1219 -----TTIKEISMQK--EDDSKNLRNQLDRLSRENRDL-----KDEIVRLN--------- 1257

Query: 4599 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4658
             + ++Q   +R R    A + A Q     S++M      +K    E+E+     +     
Sbjct: 1258 -DSILQATEQRRR----AEENALQQKACGSEIM------QKKQHLEIELKQVMQQRSEDN 1306

Query: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4718
            A+HK+  +   A  ++ D      R   E    A    + ++ LS++R+ +D        
Sbjct: 1307 ARHKQSLEE--AAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYD-------- 1356

Query: 4719 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4778
                 EE +    QF   +      ++++  Q  ED    G    + NL   +++  +E+
Sbjct: 1357 -----EEIISLKNQFETEINITKTTIHQLTMQKEED--TSGYRAQIDNLTRENRSLSEEI 1409

Query: 4779 GKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQA 4838
             +  +++     + R +     +D    K    E+S R           + +LE  LRQ 
Sbjct: 1410 KRLKNTLTQTTENLRRV----EEDIQQQKATGSEVSQR-----------KQQLEVELRQV 1454

Query: 4839 EEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEF--MKKLEEKRAELNK 4895
             +  +            E+++R+   L   +DA +T+ D++KE   +K+L +K     K
Sbjct: 1455 TQMRT------------EESVRYKQSL---DDAAKTIQDKNKEIERLKQLIDKETNDRK 1498



 Score = 50.1 bits (118), Expect = 6e-05
 Identities = 195/1130 (17%), Positives = 439/1130 (38%), Gaps = 192/1130 (16%)

Query: 4185 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4243
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587

Query: 4244 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4275
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647

Query: 4276 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4327
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4387
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759

Query: 4388 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4434
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814

Query: 4435 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4488
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865

Query: 4489 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4547
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925

Query: 4548 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4595
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985

Query: 4596 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4649
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045

Query: 4650 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT-----SLA 4692
            D +             ++   A+  +F+  L +   +       G+S K+        + 
Sbjct: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105

Query: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQ--------NKLEEALL-----FSGQFTDALQA 4739
            + N K+  +  E+ D  +    KSVE +        ++L++A          Q  ++ +A
Sbjct: 1106 ELNEKITRLTYEIED--EKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKA 1163

Query: 4740 LIDWLYRVE---PQLAEDQPVHGDIDLVMNLIDNHKAFQKEL----GKRTSSVQALKRSA 4792
            + +  Y +E     L E+     + +  +  + NH  + +E+     K  + +   K + 
Sbjct: 1164 IKEKEYEIERLRVLLQEEGTRKREYENELAKVRNH--YNEEMSNLRNKYETEINITKTTI 1221

Query: 4793 RELIEGSRDDSSWVKVQMQELSTR-----------WETVCALSISKQTRLEAALRQ---- 4837
            +E+     DDS  ++ Q+  LS              +++   +  ++   E AL+Q    
Sbjct: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281

Query: 4838 AEEFHSVVHALLE----WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAEL 4893
            +E      H  +E        +E   R    L   E+A +T+ D++KE  +   E + E 
Sbjct: 1282 SEIMQKKQHLEIELKQVMQQRSEDNARHKQSL---EEAAKTIQDKNKEIERLKAEFQEEA 1338

Query: 4894 NKATTMGDTVLAI--CHPDSITTIKHW----ITIIRARFEEVLAWAKQHQQRLASALAGL 4947
             +     + +  +   + + I ++K+     I I +    ++    ++      + +  L
Sbjct: 1339 KRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNL 1398

Query: 4948 IAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE---------------HQT 4992
              +   L   +  L+   T  T+  + V  ++I++ KA  +E                Q 
Sbjct: 1399 TRENRSLSEEIKRLKNTLTQTTENLRRV-EEDIQQQKATGSEVSQRKQQLEVELRQVTQM 1457

Query: 4993 FMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQI 5052
              EE  R +  +D   KT + +  +   L+    ++DK    RK     +      Q  +
Sbjct: 1458 RTEESVRYKQSLDDAAKTIQDKNKEIERLKQ---LIDKETNDRKCLEDENARLQRVQYDL 1514

Query: 5053 ETKN----PRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANF--DFDIWRKKYM 5106
            +  N      +N L  + Q++  L ++  R   +   + +++  F N   +  + ++K  
Sbjct: 1515 QKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVE 1574

Query: 5107 RWMNH-KKSRVMDFFRRIDKDQDGKITRQEFIDGILSSKFPTSRLEMSAV 5155
              +N  K++   D  +R   +++ +  R+   +  +     T +LE +++
Sbjct: 1575 EELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624



 Score = 43.1 bits (100), Expect = 0.008
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 4750 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297

Query: 4868 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4924
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356

Query: 4925 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 4981
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416

Query: 4982 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5041
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473

Query: 5042 SLYPSGSQTQIETKNPRVNLLVSKW 5066
             +   G +  ++  N R     SKW
Sbjct: 474  KIVHKGDECILKDNNER-----SKW 493



 Score = 35.8 bits (81), Expect = 1.2
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 5410 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5437
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 2822 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2849



 Score = 35.4 bits (80), Expect = 1.6
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 5417 SRPGSRAGSKAGSRASSRRGSDASDFD 5443
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 2825 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2851



 Score = 33.1 bits (74), Expect = 7.8
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 5395 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5437
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 2798 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2841


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score =  577 bits (1488), Expect = e-164
 Identities = 350/1260 (27%), Positives = 651/1260 (51%), Gaps = 131/1260 (10%)

Query: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660
            +E       + L W+ + + ++D   WG DL SVE H+ +H+ +H +I ++   L + K 
Sbjct: 181  DEFTKHVTSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKA 240

Query: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720
               + +A         +++LE +Y  LL  S  +  HL  L N +   + E++W+N+ EE
Sbjct: 241  DLREKSA---------IYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEE 291

Query: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
            EE+ YDWS++NTNIA+K++  +  M +L+ KE+ +  +++ ++QL+L  HPA   IEAY 
Sbjct: 292  EELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYM 351

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
              +QTQWSWILQ+ +C++ H+KEN AYF+FF +A+    YL+ L+D+I++KY CD++  +
Sbjct: 352  DTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPL 411

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
              L + ++E  +E+E++L+YK  + NL+ K+K I+QLKPRN D      I ++A+CDY+Q
Sbjct: 412  QHLLEQIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQ 471

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
             +  ++K DEC+L +N+ R+KW V  P G + +VPSV   +PPPN  AVDL+ +IEQ Y+
Sbjct: 472  DQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYE 531

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
             +L LW++ +INMKS+VSWHY + +I++IRA  +A +KTM   ++ + +++L+  +++F+
Sbjct: 532  AILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFI 591

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELL---------------------------- 1052
             +SQ S++F   D  +++ +    +++YQ L+                            
Sbjct: 592  RNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNH 651

Query: 1053 -KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEK 1111
             K  E   + +      + E++ IR ++E+CE R+  +     ++   H    +I E + 
Sbjct: 652  NKVIETNRENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKS 711

Query: 1112 LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL 1171
            ++ + + + +    + N+ ++  +    S     L++E+  + Q +  +  ++  Y++ L
Sbjct: 712  VQNDSQAIAE----VLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSL 767

Query: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHA 1231
             TV  +L+     E ++K+YE +L EEE V  D + +E     LK+ +++++ K+ +   
Sbjct: 768  CTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLAT 827

Query: 1232 LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKS 1291
            ++ ELQKA+ I  +  + Y   DLD     EK  QL +RWQ +  QID RL DLE   K 
Sbjct: 828  MKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQ 887

Query: 1292 LKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDEC 1351
            L+ YRD Y     W+   +  Q  ++  +  +S T+   LN+QK L SEI  K+ K +E 
Sbjct: 888  LRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEV 947

Query: 1352 QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALV 1411
            QK AE  + ++KDYELQ  +Y + +++    P+KR  +QS + +I+QE  D+  RY  L+
Sbjct: 948  QKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELL 1007

Query: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471
            T    Y +F  + LK L  E+  L+  K E +E             + L+ A  A     
Sbjct: 1008 TRSGDYYRFLSEMLKSL--EDLKLKNTKIEVLE-------------EELRLARDANSENC 1052

Query: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSE 1531
            +K K   + +   + + S+       F AK      +E + + E   K+ +++ +  + +
Sbjct: 1053 NKNKFLDQNLQKYQAECSQ-------FKAKLAS--LEELKRQAELDGKSAKQNLDKCYGQ 1103

Query: 1532 SLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTV 1591
             +K+L E  T    ++E++         K + + + D   Q +N     Q+A       +
Sbjct: 1104 -IKELNEKITRLTYEIEDE---------KRRRKSVEDRFDQQKNDYDQLQKARQCEKENL 1153

Query: 1592 ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIE--QKLNEAKI 1649
              +K +S++   +K+ +         ++     L+E G +  + +  L +   ++ E+K 
Sbjct: 1154 GWQKLESEKAIKEKEYE---------IERLRVLLQEEGTRKREYENELAKASNRIQESKN 1204

Query: 1650 KCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSER 1709
            +C Q+                  ++E    +  +K LE+ K +++ L D L N  K +  
Sbjct: 1205 QCTQV------------------VQERESLLVKIKVLEQDKARLQRLEDEL-NRAKSTLE 1245

Query: 1710 AGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKA 1769
            A T+ KQ +E                E+ ++  +L       Q  T      +  +K+++
Sbjct: 1246 AETRVKQRLE---------------CEKQQIQNDL------NQWKTQYSRKEEAIRKIES 1284

Query: 1770 QHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKM 1829
            + EK   +  ++    +  Q  +++    +    + KL+ + +E +   ET  +  ++++
Sbjct: 1285 EREKSEREKNSLRSEIERLQAEIKR----IEERCRRKLEDSTRETQSQLETERSRYQREI 1340



 Score = 63.9 bits (154), Expect = 4e-09
 Identities = 124/642 (19%), Positives = 249/642 (38%), Gaps = 89/642 (13%)

Query: 3265 QSAAKSTSTQGLEHDLD---------DVNARWKTLNKKVAQRAAQLQEALLHCGRFQDAL 3315
            Q     TS Q   +DLD          +  RW+ ++K++  R   L++ +     ++D  
Sbjct: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895

Query: 3316 ESLLSWMVDTEELVAN-QKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIA 3374
            ++   W+ D +    + +     +   V   + EQK L   +  ++   E +++  E  A
Sbjct: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCA 955

Query: 3375 TTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ-------FHETLEPL 3427
             + +  +      QL+   S  E LLN    R        V+ Q+       + E L   
Sbjct: 956  NSIKDYE-----LQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRS 1010

Query: 3428 NEWLTTIEKRLVNCEPI---GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQ---- 3480
             ++   + + L + E +    T+   LEE++   +    +  N NK L Q +   Q    
Sbjct: 1011 GDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECS 1070

Query: 3481 -------SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3533
                   SL+ L  + + D   +K +  +  Y +I+E +   + L  + + + K   +  
Sbjct: 1071 QFKAKLASLEELKRQAELDGKSAKQNLDKC-YGQIKELNEKITRLTYE-IEDEKRRRKSV 1128

Query: 3534 VELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSE------------LRVLQEDILLRKQNV 3581
             +  +     +D+L K    +    G  K +SE            LRVL ++   RK+  
Sbjct: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREY 1188

Query: 3582 DQALLNGLELLKQTTGDEVLIIQDK---------LEAIKARYKDITKLSTDVAKTLEQAL 3632
            +  L      ++++      ++Q++         LE  KAR + +         TLE   
Sbjct: 1189 ENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAET 1248

Query: 3633 QLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDS 3692
            ++ +RL    ++       ++ +L  ++TQ  + EEA +     +E  +  KN+   L S
Sbjct: 1249 RVKQRLECEKQQ-------IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS---LRS 1298

Query: 3693 LNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3752
              E   A ++ +  R R  LE    E   +   +    ++   EID    R     +   
Sbjct: 1299 EIERLQAEIKRIEERCRRKLEDSTRETQSQ---LETERSRYQREIDKLRQRPYGSHRETQ 1355

Query: 3753 AELSWITETEKKLMSLGDIRLEQDQTSAQLQ----VQKTFTMEILRHKDIIDDLVK---- 3804
             E  W  +T K +       L +  T+ QL     + KT   ++L+ K  ++++      
Sbjct: 1356 TECEWTVDTSKLVFD----GLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQP 1411

Query: 3805 ----SGHKIMTACSEEEKQSM-KKKLDKVLKNYDTICQINSE 3841
                +G     + S +EK S+ + K  K++    T+  + ++
Sbjct: 1412 FLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQ 1453



 Score = 53.5 bits (127), Expect = 6e-06
 Identities = 145/820 (17%), Positives = 331/820 (40%), Gaps = 132/820 (16%)

Query: 4185 QYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ-IEELKQFKSEAYQQQIEMERLNH 4243
            QY + + A+++ + I    L S      D+E ++   I +LK  + E Y + I    L++
Sbjct: 528  QYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHY 587

Query: 4244 QAELLLKKVTE---ESDKHTVQDPLMELKLIWDSL------------------------- 4275
            Q  +   + +E   + DK  +Q    + +  + +L                         
Sbjct: 588  QEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQ 647

Query: 4276 ---EERII--NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS-EQKPVG--GDPKAI 4327
                 ++I  NR++  +   + +      L ++   + H EG ++ +  P+   G    I
Sbjct: 648  DVNHNKVIETNRENDKQETWMLM-----ELQKIRRQIEHCEGRMTLKNLPLADQGSSHHI 702

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4387
             +++ +   +QND    Q+  E +N+  + L      E+   LQN++  L Q+ +N+   
Sbjct: 703  TVKINELKSVQND---SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGV 759

Query: 4388 TE-------------QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPE 4434
            T+             Q   Q +  L+  +    E E +   L   E +    K +     
Sbjct: 760  TDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKI----- 814

Query: 4435 TAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET------NIDQDINNLKE 4488
              K  LN+   + A       T K+ +QK QQ+ ++  +             + +  L +
Sbjct: 815  --KNDLNLKKSLLA-------TMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTD 865

Query: 4489 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF 4547
            +W+ ++ +++ R   LE+ +     + ++ Q F  WL  A++   ++ S      +TV+ 
Sbjct: 866  RWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMR 925

Query: 4548 QIDEHKVFANEVNSHREQIIELDKTGT---------HLKYFSQKQDVVLIKNLLIS---V 4595
             ++E K   +E++  R++  E+ K             L+  S    +  + N+ I    +
Sbjct: 926  FLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMI 985

Query: 4596 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESE------KSLDSELEIAN 4649
            QS    ++Q   +      +   R+  ++   S++++ LE+ +      + L+ EL +A 
Sbjct: 986  QSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLAR 1045

Query: 4650 DPD------------KIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4697
            D +             ++   A+  +F+  L +   +       G+S K+        +K
Sbjct: 1046 DANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIK 1105

Query: 4698 -LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQA---LIDWLYRVEPQLAE 4753
             L++ ++ L  + +    +    +++ ++      Q   A Q     + W  ++E + A 
Sbjct: 1106 ELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGW-QKLESEKAI 1164

Query: 4754 DQPVHGDIDLVMNLIDNH----KAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQ 4809
             +  + +I+ +  L+       + ++ EL K ++ +Q  K    ++++        +KV 
Sbjct: 1165 KEKEY-EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKVL 1223

Query: 4810 MQELSTRWETVCALSISKQTRLEAALRQAE----EFHSVVHALLEW---LAEAEQTLR-- 4860
             Q+ +        L+ +K T LEA  R  +    E   + + L +W    +  E+ +R  
Sbjct: 1224 EQDKARLQRLEDELNRAKST-LEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKI 1282

Query: 4861 --FHGVLPDDEDALRTLIDQHKEFMKKLEEK-RAELNKAT 4897
                     ++++LR+ I++ +  +K++EE+ R +L  +T
Sbjct: 1283 ESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDST 1322



 Score = 52.0 bits (123), Expect = 2e-05
 Identities = 132/763 (17%), Positives = 306/763 (40%), Gaps = 86/763 (11%)

Query: 3579 QNVDQALLNGLELLKQTTG-----DEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3633
            QN  QA+   L  LK         ++   +Q+++  +  + ++I  ++     +L     
Sbjct: 713  QNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRA 772

Query: 3634 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3693
            L + +  T + L  +    E  L   ET  L  ++    +   K++K +    K+LL ++
Sbjct: 773  LLQAILQTEDMLKVY----EARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATM 828

Query: 3694 N-------EVSSALLELVPWRARE--GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRS 3744
                    ++ S   +  P    +     + V +  +R++ +   I  ++ +++  I + 
Sbjct: 829  KTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQL 888

Query: 3745 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQ-LQVQKTFTMEILRHKDIIDDLV 3803
            + +     A   W+ + +++  SL  ++     T  + L  QK    EI   +D  +++ 
Sbjct: 889  RNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQ 948

Query: 3804 KSGHKIMTACSEEEKQ--SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3861
            K       +  + E Q  S    L+ +L        I S   + L+ A  +  ++ E   
Sbjct: 949  KIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLT 1008

Query: 3862 ELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLEL 3921
                +      ++  L    L+   +   +EE R  R+  +E+       NK   Q L+ 
Sbjct: 1009 RSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC----NKNKFLDQNLQK 1064

Query: 3922 SPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981
               E    + K  + + L  Q + D K     LD+   Q  + ++KI ++   +E   E+
Sbjct: 1065 YQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIED--EK 1122

Query: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041
             R+        + ++++  + KN   D ++LQ   +  K+        + G  K  S KA
Sbjct: 1123 RRR--------KSVEDRFDQQKN---DYDQLQKARQCEKE--------NLGWQKLESEKA 1163

Query: 4042 VQDKLDQMVFIWENIHTLVEEREAKLLDV-MELAEKFWCDHMSLIVTIKDTQDFIRDLED 4100
            +++K  ++    E +  L++E   +  +   ELA+        +  +       +++ E 
Sbjct: 1164 IKEKEYEI----ERLRVLLQEEGTRKREYENELAKA----SNRIQESKNQCTQVVQERES 1215

Query: 4101 PGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNS 4160
              +   V++Q +   + + +E++  +  L+    +   L     E +K  ++  +++   
Sbjct: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL-----ECEKQQIQNDLNQ--- 1267

Query: 4161 AWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQ 4220
             W +     ++ I K+E   + + + ++ L+             + +  +  +++ ++++
Sbjct: 1268 -WKTQYSRKEEAIRKIESEREKSEREKNSLR-------------SEIERLQAEIKRIEER 1313

Query: 4221 IEELKQFKSEAYQQQIEMERLNHQAEL-LLKKVTEESDKHTVQD---PLMELKLIWDSLE 4276
                 +  +   Q Q+E ER  +Q E+  L++    S + T  +    +   KL++D L 
Sbjct: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373

Query: 4277 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKP 4319
            +++   Q   E  L+     +  LD+LL      E + SE +P
Sbjct: 1374 KKVTAMQ-LYECQLID----KTTLDKLLKGKKSVEEVASEIQP 1411



 Score = 50.1 bits (118), Expect = 6e-05
 Identities = 99/551 (17%), Positives = 224/551 (40%), Gaps = 68/551 (12%)

Query: 2523 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQV 2582
            L Q  +  +  L+     LT+ +TV   L +    +  +  +   L++  ++L T + ++
Sbjct: 773  LLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTEL 832

Query: 2583 QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRC 2642
            Q   Q  +    QY             P  D  L G   E++  +T +W  +  Q+  R 
Sbjct: 833  QKAQQIHSQTSQQY-------------PLYDLDL-GKFGEKVTQLTDRWQRIDKQIDFRL 878

Query: 2643 DWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVST-HPDAMNQQLETAQKMKQEIQ 2701
              +++ I +   Y+   ++    L D   +  S  ++     + + + L   + +  EI 
Sbjct: 879  WDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEIS 938

Query: 2702 QEKKQIKVAQALCEDLSALVKEEYLK-AELSRQLEGILK-----------SFKDVEQKAE 2749
             ++ + +  Q + E  +  +K+  L+ A  +  LE +L            S   +++ A+
Sbjct: 939  GKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAAD 998

Query: 2750 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2809
             H ++++    S   ++ +S   ++  D K +        + K++VLE  ++  +D +  
Sbjct: 999  VHARYIELLTRSGDYYRFLSEMLKSLEDLKLK--------NTKIEVLEEELRLARDANSE 1050

Query: 2810 LTAQSHMYEKTI----AEGENLLLKTQGSEKAALQLQLN--TIKTNWDTFNKQVKERENK 2863
               ++   ++ +    AE      K    E+   Q +L+  + K N D    Q+KE   K
Sbjct: 1051 NCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK 1110

Query: 2864 LKE---SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2920
            +      +E   + ++ VE  +       + L++ + C     G   +   K++ KE + 
Sbjct: 1111 ITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAI-KEKEY 1169

Query: 2921 HFGMVELL------------NNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHS 2966
                + +L            N  A +   + E   +   V  E +SL+ K+  V EQ  +
Sbjct: 1170 EIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIK-VLEQDKA 1228

Query: 2967 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3026
            +   LE+   + K   E     K++L+C K+Q+        Q   N++ T    ++++++
Sbjct: 1229 RLQRLEDELNRAKSTLEAETRVKQRLECEKQQI--------QNDLNQWKTQYSRKEEAIR 1280

Query: 3027 ALKHQVDLAKR 3037
             ++ + + ++R
Sbjct: 1281 KIESEREKSER 1291



 Score = 48.5 bits (114), Expect = 2e-04
 Identities = 140/703 (19%), Positives = 270/703 (38%), Gaps = 92/703 (13%)

Query: 3967 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026
            KI + +E  E  +     P +       I  +I+E K+V  D + +  +   LK    +M
Sbjct: 674  KIRRQIEHCEGRMTLKNLPLADQGSSHHITVKINELKSVQNDSQAIAEVLNQLK----DM 729

Query: 4027 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4086
            +A   G++K      +Q+++  +    ENI+ + +     L           C   +L+ 
Sbjct: 730  LANFRGSEKYCY---LQNEVFGLFQKLENINGVTDGYLNSL-----------CTVRALLQ 775

Query: 4087 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINL---------GS 4137
             I  T+D ++  E    +   V    +  E  R  +  ++ +L++  +L          +
Sbjct: 776  AILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKA 835

Query: 4138 ELIAACGEPDKPIVK-------KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGL 4190
            + I +      P+         + + +L   W  ++K    R+  LE+ ++    Y+D  
Sbjct: 836  QQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNY 895

Query: 4191 QAVFDWVDIAGGKLASMSPIG-TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4249
            QA   W+  A  +  S+  +   D  TV + + E K   SE   ++ + E +   AEL  
Sbjct: 896  QAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELC- 954

Query: 4250 KKVTEESDKHTVQDPLMELKLIWDSLEERI---INRQ--HKLEGALLALGQFQHA-LDEL 4303
                     ++++D  ++L      LE  +   I R       G +L      HA   EL
Sbjct: 955  --------ANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIEL 1006

Query: 4304 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV-LAHQSTVEAVNKAGNDLIESS 4362
            L         LSE      D   ++++  K  VL+ ++ LA  +  E  NK  N  ++ +
Sbjct: 1007 LTRSGDYYRFLSEMLKSLED---LKLKNTKIEVLEEELRLARDANSENCNK--NKFLDQN 1061

Query: 4363 AGE---EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDT 4419
              +   E S  + KL  L +  +      +  KQ LD    Q K  + +I  L   + D 
Sbjct: 1062 LQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDE 1121

Query: 4420 ERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNI 4479
            +R                        V   F+ ++  Y  L QK +Q         +   
Sbjct: 1122 KRR--------------------RKSVEDRFDQQKNDYDQL-QKARQCEKENLGWQKLES 1160

Query: 4480 DQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPS 4539
            ++ I   + + E +   L E  T+  E  N   +  N +Q+  N  TQ      V  R S
Sbjct: 1161 EKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQV-----VQERES 1215

Query: 4540 LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599
            L++   + + D+ ++   E   +R +     +T    +   +KQ    I+N L    ++W
Sbjct: 1216 LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ---IQNDL----NQW 1268

Query: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLD 4642
            +    R  E  R ++  R+++++   +    +E L+   K ++
Sbjct: 1269 KTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE 1311



 Score = 43.1 bits (100), Expect = 0.008
 Identities = 70/325 (21%), Positives = 127/325 (39%), Gaps = 37/325 (11%)

Query: 4750 QLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
            Q AE   V   +DL  V   I++H+     +G     +  +K   RE            K
Sbjct: 198  QRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLRE------------K 245

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
              + +L   +E +   S  +   L    RQ +         + W+ + E+      +L D
Sbjct: 246  SAIYQLEEEYENLLKASFERMDHL----RQLQNIIQATSREIMWINDCEE----EELLYD 297

Query: 4868 DEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4924
              D    +  + + F   M +LE K  ELNK     D ++   HP S   I+ ++  ++ 
Sbjct: 298  WSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPAS-DKIEAYMDTLQT 356

Query: 4925 RFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQE-IE 4981
            ++  +L   K     L   +A      + +  EA L  LQ +       DK +  Q  +E
Sbjct: 357  QWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLE 416

Query: 4982 EVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPAS 5041
            ++K L  E +  +E   + Q  V+K  K  + +  +P   +S+ P++ +     K+    
Sbjct: 417  QIKELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNP-DYRSNKPIILRALCDYKQ--DQ 473

Query: 5042 SLYPSGSQTQIETKNPRVNLLVSKW 5066
             +   G +  ++  N R     SKW
Sbjct: 474  KIVHKGDECILKDNNER-----SKW 493



 Score = 42.4 bits (98), Expect = 0.013
 Identities = 102/546 (18%), Positives = 223/546 (40%), Gaps = 84/546 (15%)

Query: 2465 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2524
            +K  +   KS  A +K  + K Q++  + ++  +      +  ++ + +T++  +WQ ++
Sbjct: 814  IKNDLNLKKSLLATMKTELQKAQQIHSQTSQ--QYPLYDLDLGKFGEKVTQLTDRWQRID 871

Query: 2525 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI-DPN----MLNTQR 2579
            +    R   LE+    L  ++       +WL + +     L  +   D N     LN Q+
Sbjct: 872  KQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQK 931

Query: 2580 -------------QQVQILLQEFATRKPQYE----QLTAAGQGILSRPGEDPSLR---GI 2619
                         ++VQ + +  A     YE      T+  + +L+ P +   ++   G+
Sbjct: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991

Query: 2620 VKEQLAAVTQKWDSLTGQ-------LSDRCDWIDQAIVKSTQYQSL---LRSLSDKLSDL 2669
            + ++ A V  ++  L  +       LS+    ++   +K+T+ + L   LR   D  S+ 
Sbjct: 992  ILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSEN 1051

Query: 2670 DNK---LSSSL-AVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2725
             NK   L  +L            +L + +++K++ + + K  K     C      + E+ 
Sbjct: 1052 CNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKI 1111

Query: 2726 LKAELSRQLEGILKSFKDVEQK---AENHVQHLQSACASSHQFQQMSRDFQAW--LDTKK 2780
             +  L+ ++E   +  K VE +    +N    LQ A       +Q  ++   W  L+++K
Sbjct: 1112 TR--LTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------RQCEKENLGWQKLESEK 1162

Query: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKT-------IAEGENLLLKTQG 2833
              + K + I     +L+      +++   L   S+  +++       + E E+LL+K + 
Sbjct: 1163 AIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESKNQCTQVVQERESLLVKIKV 1222

Query: 2834 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2893
             E+   +LQ             ++++  N+ K +LE   + K+++E     I   QN+L 
Sbjct: 1223 LEQDKARLQ-------------RLEDELNRAKSTLEAETRVKQRLECEKQQI---QNDLN 1266

Query: 2894 EIKFCLDPAEGENSIAKLKS----LQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDE 2949
            + K     +  E +I K++S     ++E +     +E L      +   C    E  T E
Sbjct: 1267 QWK--TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE 1324

Query: 2950 NKSLIQ 2955
             +S ++
Sbjct: 1325 TQSQLE 1330



 Score = 41.2 bits (95), Expect = 0.029
 Identities = 58/293 (19%), Positives = 126/293 (43%), Gaps = 40/293 (13%)

Query: 2323 KSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKA-IAAVKS 2371
            KSLED K    K  +   E++   ++    CN             A  +  KA +A+++ 
Sbjct: 1022 KSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEE 1081

Query: 2372 --GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK---DKIAELNTKL 2426
                A L+G+    N ++ +    +  + + +T +++  ED     K   D+  +     
Sbjct: 1082 LKRQAELDGKSAKQNLDKCYGQ--IKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDY 1139

Query: 2427 SKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKV 2486
             +LQKA++     + W +  ++ A K ++         ++ +  + + +E EL +  N++
Sbjct: 1140 DQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRI 1199

Query: 2487 QELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQT 2546
            QE K++ T++++E          + +L +I    Q+  +L     Q+LE+  N       
Sbjct: 1200 QESKNQCTQVVQER---------ESLLVKIKVLEQDKARL-----QRLEDELNRAKSTLE 1245

Query: 2547 VEAQLKQWL-VEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2598
             E ++KQ L  EK+        +  D N   TQ  + +  +++  + + + E+
Sbjct: 1246 AETRVKQRLECEKQ-------QIQNDLNQWKTQYSRKEEAIRKIESEREKSER 1291



 Score = 35.8 bits (81), Expect = 1.2
 Identities = 16/28 (57%), Positives = 22/28 (78%)

Query: 5410 ADSKKTPSRPGSRAGSKAGSRASSRRGS 5437
            A   ++ SR GSR+GS++GSR+ SRRGS
Sbjct: 2223 APGSRSGSRSGSRSGSRSGSRSGSRRGS 2250



 Score = 35.4 bits (80), Expect = 1.6
 Identities = 16/27 (59%), Positives = 20/27 (74%)

Query: 5417 SRPGSRAGSKAGSRASSRRGSDASDFD 5443
            SR GSR+GS++GSR+ SR GS    FD
Sbjct: 2226 SRSGSRSGSRSGSRSGSRSGSRRGSFD 2252



 Score = 33.1 bits (74), Expect = 7.8
 Identities = 20/44 (45%), Positives = 27/44 (61%), Gaps = 1/44 (2%)

Query: 5395 SGLITTAAARVRTQFADSK-KTPSRPGSRAGSKAGSRASSRRGS 5437
            +GL    AA V ++   S     S PGSR+GS++GSR+ SR GS
Sbjct: 2199 TGLRLLEAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGS 2242


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
            [Homo sapiens]
          Length = 8797

 Score =  372 bits (955), Expect = e-102
 Identities = 721/4028 (17%), Positives = 1590/4028 (39%), Gaps = 442/4028 (10%)

Query: 1285 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1341
            L   G  ++Y     + L++ I   +  Q + ++     +   A QL   +QQK     I
Sbjct: 1228 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1285

Query: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1400
              K+  + +    A+Q    + D   + +    + +D  ++S   R R +    + ++++
Sbjct: 1286 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1342

Query: 1401 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS--- 1457
                T    +V    +Y+   G S +R      SLE    E +E+ KE  K   +I+   
Sbjct: 1343 ERFETNKETVV----RYLFQTGSSHERFLSFS-SLESLSSE-LEQTKEFSKRTESIAVQA 1396

Query: 1458 -KTLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE 1510
               +K+A +    P +KQ      K   E++   ++ L E ++T+++   K      D  
Sbjct: 1397 ENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHF 1451

Query: 1511 RNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLL 1570
             +  E     + E       + L  L+ S ++ D+++ +  +    QE + KL  I  L 
Sbjct: 1452 GSNFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLE 1504

Query: 1571 TQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKE 1627
             + ++  + +   E+  I     ++++Y  +  E  + ++G+    L++  K  EN  K 
Sbjct: 1505 EEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKI 1564

Query: 1628 NGEKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT------------- 1671
                   EDK  +  K+  +     K  Q ++   Q+ + L   +T              
Sbjct: 1565 QQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDS 1624

Query: 1672 ------AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHF 1725
                  A++++ E +  +++ +E +T +ENLL     ++K+           +    T  
Sbjct: 1625 CVQEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWL 1671

Query: 1726 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1785
            + G+ K++  E D              +   +  +  + Q ++A   +++SQ      A+
Sbjct: 1672 ERGEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------AS 1711

Query: 1786 QSAQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFD 1843
              +++L  K+  +   S ++ + ++ ++++L   +        K++    S+  E ++FD
Sbjct: 1712 FYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFD 1771

Query: 1844 ADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNR 1903
                 F  W++    EL+        I      L R K  + +V S KG+L+  ++ G+ 
Sbjct: 1772 ELLLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHL 1827

Query: 1904 VLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKY 1960
                          K+ +     ++      A D F+       V+      L  L +  
Sbjct: 1828 A-------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL 1874

Query: 1961 QHYEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEK 2019
            Q +   S G+L  L Q  EAT S + +E   ++ K+L   L+  KAL+    S  V+++ 
Sbjct: 1875 QSHASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDG 1928

Query: 2020 LKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDG 2079
            +   A+  L    S    +   + T D + G  E +   +  +  +         + QD 
Sbjct: 1929 ILSKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQ 1986

Query: 2080 LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM 2139
             +E+L  + ++E    ++        ALQ  +     LE ++   +  +  + +K K+  
Sbjct: 1987 KEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA 2046

Query: 2140 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETK 2199
            +  D + A  +  ++  L   + +      E   +   L   +  ++NL   +   LE  
Sbjct: 2047 QK-DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENA 2105

Query: 2200 TQAL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEIS 2245
            +  + T   +  KD  +L               Y Q+    F    KHL    S LK+I 
Sbjct: 2106 SSVIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIH 2160

Query: 2246 SHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLK 2299
            S     + +D    ++K  ++S+K +E  D ++      + V S +++++ +        
Sbjct: 2161 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------N 2214

Query: 2300 SWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISA 2358
            + + +  + +  +     AE+L K  E   K +   +L+  E+  KVN+    L  L   
Sbjct: 2215 NCVPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKN 2267

Query: 2359 VTTP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKD 2400
            + TP                AK I  V  G  + +    +T  E+F  +     T +++ 
Sbjct: 2268 LETPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEES 2326

Query: 2401 MTDISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2459
            + + +       L  +KD   EL ++ S +   QE  +++ +        +     T   
Sbjct: 2327 LMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLI 2386

Query: 2460 TDTEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKL 2493
               EAV     KTQ    +S E    +++ + QE                     L+ KL
Sbjct: 2387 KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKL 2446

Query: 2494 TEL----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDR 2530
             +L                + +   T  A   KQ+       +T+ + ++Q   +  +  
Sbjct: 2447 HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKD 2506

Query: 2531 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQE 2588
            +Q L++ ++ L  F+    +L  W+ E E   +   LG           +  +V++ L E
Sbjct: 2507 KQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGE 2566

Query: 2589 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQA 2648
                +   ++L+  GQ +LS  G      G +  QL    Q    +T +    C     A
Sbjct: 2567 LLAARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VA 2622

Query: 2649 IVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIK 2708
            + +    +  L+S+   +  + ++L+ + +     D + ++L   Q +   + + + ++K
Sbjct: 2623 LQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVK 2680

Query: 2709 VAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2767
            +  A+ +   AL    +  +  +  QLE + + + D+   + +    L+S  +  + + +
Sbjct: 2681 LNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVE 2740

Query: 2768 MSRDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYE 2818
                 + W+++   +Q   HP+  +         LD L+S++ + +D ++ L        
Sbjct: 2741 RKNQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------H 2791

Query: 2819 KTIAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQ 2877
            + IA+   L  KT+  S K   Q +L   KT ++      KE+  K++E ++  L Y + 
Sbjct: 2792 RLIAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDA 2848

Query: 2878 VETLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMD 2919
            V     W+                    Q  L +IK  +D  E G + +++++SL  E+ 
Sbjct: 2849 VHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2908

Query: 2920 QHFGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 2977
            Q+      EL++    +L +  +  ++ V      L   V  +          +  + Q 
Sbjct: 2909 QNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQA 2968

Query: 2978 FKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3037
             ++F  + K   +QL   + +    + +       + L  LQ  +   + LK Q++   R
Sbjct: 2969 LEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCR 3028

Query: 3038 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3097
             ++DL   +    G          + +E++ L  Q  + C   E  LQ         +  
Sbjct: 3029 FSRDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRF 3069

Query: 3098 FSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEE 3157
               F +F   L +          + +    +   L+K++  ++ ++N      MML+  E
Sbjct: 3070 RKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE 3129

Query: 3158 TSPDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILL 3211
                L+      GI+  + A  +           +E  +E    ++++F    +     L
Sbjct: 3130 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3189

Query: 3212 QKAEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQ 3265
             K E+  HE S     +  +   QQ     + +    EP    L+ K Q + W GQ    
Sbjct: 3190 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ---- 3244

Query: 3266 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3325
            +A+KS       H +  +++++  L+    ++ ++L   +    +F   ++ L  WM D 
Sbjct: 3245 AASKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDA 3299

Query: 3326 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI 3385
              ++ +   P+++  V+ ++  + + L  +  +++  +++I   GE +     P     I
Sbjct: 3300 IHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTI 3359

Query: 3386 LKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3445
             +QL  +   W +LL+       QLEG       + + +   + W+ ++E  L   E   
Sbjct: 3360 QQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQH 3419

Query: 3446 TQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY 3505
             +       + + K L +++++++  L      G  +       +  + Q +L   Q  Y
Sbjct: 3420 AELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERY 3473

Query: 3506 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS 3565
              IQE++       ++ +   + +  D      WL +  +KL + SV +         ++
Sbjct: 3474 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THET 3530

Query: 3566 ELRVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTD 3623
             LR LQE  L       QALLN  L   +      +   +D+ LE+++  ++      ++
Sbjct: 3531 TLRDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSE 3588

Query: 3624 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3683
                    +   R +    +++  WL   E E +S  T+        + Q+   ++KK  
Sbjct: 3589 TRTQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKVSPRTRRQSNRATKEIQLH--QMKKWH 3645

Query: 3684 KNNKALLDSLNEVSSALLELVPW---RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA 3740
            +   A  D + EV +   E++      +R G +    +   RY+ +   + ++++ ++  
Sbjct: 3646 EEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--ATQLTSRYQALLLQVLEQIKFLEEE 3703

Query: 3741 ILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RH 3795
            I   ++ + +  +   W   T K   +   +  + D+    +  +K  T+E+L     + 
Sbjct: 3704 IQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKG 3760

Query: 3796 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3855
              ++    + G + +    E E + ++K++   ++    +     + ++ LE+   L  +
Sbjct: 3761 HSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKE 3820

Query: 3856 FWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTG 3915
            F +  + L  W+ E Q I+     P +E    + Q  +++ L++ +  H+P +  + + G
Sbjct: 3821 FSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKG 3880

Query: 3916 PQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 3975
              LLEL   +  ++++K     + Y  +    K+   +L+  +     ++ ++ ++ + L
Sbjct: 3881 EALLELV--QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWL 3938

Query: 3976 ERIVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
             ++  RL  P  + ++ +E I +Q++ +K +  ++   +     L+ +G+ +I +     
Sbjct: 3939 LQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQC---- 3994

Query: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVT 4087
                A  +Q KL Q      N+H  ++  +     +   A++ +         H+S   T
Sbjct: 3995 ----ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDT 4044

Query: 4088 IKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGE 4145
            ++  Q ++  ++ P ++PS  +     AE I++      LQE+    ++L   L + C +
Sbjct: 4045 LQQCQAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-D 4098

Query: 4146 PDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA 4205
                 VK +  ++     ++ +    ++ + +   Q   + +     ++ ++  A  +L 
Sbjct: 4099 LSNASVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQ 4154

Query: 4206 SMSPIGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD 4263
            +M    ++LE    +  + ++K F  +   +Q  +  +  +   L KK  EES +H   +
Sbjct: 4155 NMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEIN 4212

Query: 4264 PLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGD 4323
             L +    W  L  +  N   + E  L     +   ++ +  +L               +
Sbjct: 4213 HLNDQ---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAE 4269

Query: 4324 PKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQN 4383
              A+ +E  K   L   +   +  +E +      +IE    ++   ++ +   L QRW  
Sbjct: 4270 STAVHLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQ 4327

Query: 4384 VLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH 4443
            + +  +++ Q     L +        ++L +W  + + ++  +      P+ A+  L  H
Sbjct: 4328 LEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDH 4387

Query: 4444 MEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4503
            + +C+  EAK+   KSL++   +++A    +    I + +++ +     +   + +R+  
Sbjct: 4388 LAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKY 4447

Query: 4504 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4563
            L +AL+   +F  ++    + + Q E+ +       L+ D V  Q+   K     + +++
Sbjct: 4448 LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ 4507

Query: 4564 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4623
             ++  L   G  L     +Q+   +   L  +QS ++ V+Q+   R + L+      K F
Sbjct: 4508 NEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHF 4567

Query: 4624 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4683
             E + K   WL++++     E+ + N+  ++ TQLA+++   +      ++  T  RTG+
Sbjct: 4568 KEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQ 4627

Query: 4684 SLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDW 4743
            ++    +  D +  L + L+ L  +++ I   + ++  K++EA+L   ++   ++     
Sbjct: 4628 TILPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQS 4686

Query: 4744 LYRVEPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD 4801
            L  +E Q      V  D  ++  ++L D  +A   E+     +V  L +      EG R 
Sbjct: 4687 LSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRS 4742

Query: 4802 DSS-WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQT 4858
                W   +M  L T +  +   +  + + LE      +E   +   L   L   + EQ+
Sbjct: 4743 TGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQS 4802

Query: 4859 LRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHW 4918
                  LP +E      +  +      L++    L + T   + +     P +    +H 
Sbjct: 4803 KVNEETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQ 4857

Query: 4919 ITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDK 4973
            I   +   + + +   +      S +   I  Q  +   L WL+  +  L+     D + 
Sbjct: 4858 IQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNL 4917

Query: 4974 EVIPQEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGR 5032
            + I +EI +++    E Q+ +  M      + +K TK  +  +AD     + +  LD   
Sbjct: 4918 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDI 4977

Query: 5033 AGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELRE 5092
                R   ++L    SQ Q             ++ QV+  A       ND L+  +EL +
Sbjct: 4978 QEALRTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQ 5017

Query: 5093 FANFDFDI 5100
             A    D+
Sbjct: 5018 LAGNGLDV 5025



 Score =  320 bits (820), Expect = 2e-86
 Identities = 889/4830 (18%), Positives = 1871/4830 (38%), Gaps = 684/4830 (14%)

Query: 608  VQDLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666
            V+    W+D M+  L+ +E   ++L    + L   K ++  +  + S L+  ++    MT
Sbjct: 3398 VRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT 3457

Query: 667  ----APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNEL-IWLNEKEEE 721
                  L+L   ++ +R   + AK   T   +   L  LH    R      +WL +++E+
Sbjct: 3458 EHYVTQLELQDLQERYRAIQERAKEAVTKSEK---LVRLHQEYQRDLKAFEVWLGQEQEK 3514

Query: 722  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENH---PARLTIEA 778
               Y   E + +       H   +R+L + + +    Q +   +L       P+ +    
Sbjct: 3515 LDQYSVLEGDAHT------HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3568

Query: 779  YRAAMQTQWSWILQLCQCVEQHIKENTAYFE--------FFNDAKEATDYLRNLKDAIQR 830
             RA    +  W     Q  +  + E    F              ++  ++L+  ++ +  
Sbjct: 3569 DRALESLRQDW-----QAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623

Query: 831  KYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 890
            +    R S+    E  + +  +  EE+  Y+  +  +  +A+ I+     NS    + + 
Sbjct: 3624 RTR--RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQAT- 3680

Query: 891  PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVD 950
              +    Y+ + + + +  + +        + ++ S   +E+ + S        +K   +
Sbjct: 3681 --QLTSRYQALLLQVLEQIKFL--------EEEIQSLEESESSLSSYSDWYGSTHKNFKN 3730

Query: 951  LANRIEQ-----QYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH 1005
            +A +I++       + + TL     + +K +   H L+      R     ++K +  GE 
Sbjct: 3731 VATKIDKVDTVMMGKKLKTL----EVLLKDMEKGHSLLKSA---REKGERAVKYLEEGEA 3783

Query: 1006 QQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY-------------YQELL 1052
            ++    L+    D +E  +E       +   LEK +++ K++             YQE+L
Sbjct: 3784 ER----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839

Query: 1053 KSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKL 1112
               E  + E       +S+ ++++  + + E   ++ +R      +  E++  + +   L
Sbjct: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPS-VKSVR------EKGEALLELVQDVTL 3892

Query: 1113 KKELERLKDDLGTITNKCEEF-FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYI--D 1169
            K ++++L+ D   + +  +E  FS  A         SEL  V + + Q   MS   +  D
Sbjct: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQ---MSGRLVAPD 3949

Query: 1170 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK-NNIENLISTL-KQWRSEVDEK-R 1226
             L+T +L     Q A      +   + EE A   D+ NN++    TL  Q    +  K +
Sbjct: 3950 LLETSSLETITQQLA------HHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLK 4003

Query: 1227 QVFHA-LEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL--VERWQNVHVQIDNR-- 1281
            Q  HA L+       AI     + Y+  + +   H  + D L   + W +  VQ D    
Sbjct: 4004 QNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSA-VQPDLEPS 4062

Query: 1282 ----LRDLEGIGKSLKYYRDTYHPLDDWIQ-----------QVETTQRKIQENQPENSKT 1326
                L   E I K +K++R        ++             V+TT + IQ+ +    +T
Sbjct: 4063 PQPPLSRAEAI-KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QT 4117

Query: 1327 LATQLNQQKMLVS---EIEMKQSKMDECQKYAEQYSATVK--DYELQTMTYRAMVDSQQK 1381
            +  +L Q + L     EI+  +S++    + A+Q    +K    EL+    + MV   + 
Sbjct: 4118 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD 4177

Query: 1382 SPVKRRRMQSSADLIIQEFMDLRTR-----YTALVTLMTQYIKFAGDSLKRLEEEEKSLE 1436
               K +  Q+S + II++   L  +     +  +  L  Q++     S     + E+ L+
Sbjct: 4178 FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQ 4237

Query: 1437 EEKKEH-------VEKAKELQKWV----SNISKTLKDAEKAGKPPFSKQ--KISSEEIST 1483
              +  H       V   K   +W     S+   T    E   K   + Q  K + E++  
Sbjct: 4238 RTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKD 4297

Query: 1484 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK-------TLQESYNLL---FSESL 1533
            +K+++ E L      L K      ++   +LE  +K       T  E  N++   F E +
Sbjct: 4298 QKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELM 4357

Query: 1534 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDGT 1590
            +  +E Q +    +++    +  Q        IC  L   +     LI   +  M   G 
Sbjct: 4358 EWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGL 4417

Query: 1591 VELKKYQS------------------KQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1632
             E +  Q                   +++ L K +    Q L  V + T    +   + +
Sbjct: 4418 NERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM 4477

Query: 1633 SQEDKALIEQKLNEAKIKCE--QLNLKAEQSK--------KELDKVVTTAIKEETEKVAA 1682
             +E   L+   +++    C+  Q +LK  Q++        +EL K VT     E EK   
Sbjct: 4478 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-----EQEKSEV 4532

Query: 1683 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1742
            + +L+E ++  +++L       K S R     K ++ +   HF+E        + D+   
Sbjct: 4533 LGKLQELQSVYDSVLQ------KCSHRLQELEKNLVSRK--HFKE--------DFDKACH 4576

Query: 1743 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1802
             L + D+         N + +     A+++ I+ Q        ++  + L++ GQ + P 
Sbjct: 4577 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEY----ENLLLTLQRTGQTILPS 4632

Query: 1803 EKEK----LQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1858
              E     L + +  L   +   +A ++ K    + +QE +        E+   ++ + Q
Sbjct: 4633 LNEVDHSYLSEKLNALPRQFNVIVALAKDKF---YKVQEAI----LARKEYASLIELTTQ 4685

Query: 1859 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1918
             L  LEA    ++ + T L       E+ +S +   R I      + EA    +++  G 
Sbjct: 4686 SLSELEAQFLRMSKVPTDLA-----VEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF 4740

Query: 1919 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1978
              T    +    K+ H    +  L  +     + L+D    YQ +E     L   L++ +
Sbjct: 4741 RSTGQPWQP--DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4798

Query: 1979 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLP-A 2037
               SK   E +  + K     L+   +L G +    +    LK+    L D    L P A
Sbjct: 4799 EEQSKVNEETLPAEEK-----LKMYHSLAGSLQDSGIV---LKRVTIHLEDLAPHLDPLA 4850

Query: 2038 KNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ 2097
                +  +    G  + L+ ++ E   + +  + +S+  Q  +   LDW+  V++ L   
Sbjct: 4851 YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP 4910

Query: 2098 GQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDL 2157
              + LN   +Q+ I K  + ++++      +NA++ K K+         ++ L+  + +L
Sbjct: 4911 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4970

Query: 2158 SARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-- 2215
            S    +     +   A + E+ ++ + +  + +    +LE   Q L ++   G DV    
Sbjct: 4971 SELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED-AQELLQLAGNGLDVESAE 5029

Query: 2216 --LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDT 2273
              L  +M+  ++E   H  +LE LHSL+  +     P+ K  + +K  +L  + + M   
Sbjct: 5030 ENLKSHMEFFSTEDQFHS-NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRD 5088

Query: 2274 IKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQE 2333
               + + +  C  Q   +Q   + +   + +T KK+      F       S E  +KL E
Sbjct: 5089 SGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLS----EFSLLKTSSSHEAEEKLSE 5144

Query: 2334 KWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG 2393
              +L                  +S V +  + I A++   + L  E T  +  +   ++ 
Sbjct: 5145 HKAL------------------VSVVNSFHEKIVALEEKASQL--EKTGNDASKATLSRS 5184

Query: 2394 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2453
            +T++ +  T +    +D   +L+D + E     +K++KA E    M+  LQ         
Sbjct: 5185 MTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE----MIDQLQ--------- 5231

Query: 2454 QQTPAPTDTEAVK----TQVEQNKSFEAELKQNVNKVQELKDKLTELLEEN--PDTPEAP 2507
             + P  +  +A K    T +E + +F  EL+Q  + +  L+ +   +L++   P   E P
Sbjct: 5232 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5291

Query: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567
               Q +T +  +   + +      + +++   +    +T    +K W+ E +     LG 
Sbjct: 5292 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETK---EYLGN 5348

Query: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQ----GILSRPGEDPSLRGIVKEQ 2623
             +I+   ++ Q +++QILL E    +   E++    +    G+ +    + SL      Q
Sbjct: 5349 PTIE---IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL------Q 5399

Query: 2624 LAAVTQKWDSLTGQLSDRCDWIDQAIVKST----QYQSLLRSLSDKLSDLDNKLSSSLAV 2679
            LA V      +  Q+ D+   ++Q+   S     Q Q L + L+  L+ L  K  + +  
Sbjct: 5400 LAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQA 5458

Query: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2739
             T    + ++L+       E+    ++             L +   L   L++++  + +
Sbjct: 5459 KTDQKVLGEELDGCNSKLMELDAAVQKF------------LEQNGQLGKPLAKKIGKLTE 5506

Query: 2740 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKE------EQNKSHPISAKL 2793
              +   ++AEN +  L  A +   ++ +M      W++  K         N +  +  + 
Sbjct: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566

Query: 2794 DVLESLIKDHKDFSKTLTAQSHMYEKTIA----EGENLLLKTQGSEKAALQLQLNTIKTN 2849
             + ++L+++ K+    L A +   +   +    E  +  +   G E   L+  +     N
Sbjct: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5626

Query: 2850 WDTFNKQVKERENKLKE---SLEKA-----------LKYKEQV---ETLWPWIDKCQNNL 2892
                 K +K+ E +LK+   +LE+A           L  KEQ+   + L   ++  +  +
Sbjct: 5627 LQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 5686

Query: 2893 EEIKFCLDPAE-GENSIAKLK------SLQKEMD--QHFGMVELLNNTANSLLSVCEIDK 2943
            + ++ C       E+ +A L        LQ+E    QH  + +       +++    +  
Sbjct: 5687 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC------NIMQAAVVQY 5740

Query: 2944 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3003
            E    E K L Q ++    ++  K     N+       QE+  +  R  + A++     +
Sbjct: 5741 EQYEQEMKHLQQLIEGAHREIEDKPVATSNI-------QELQAQISRHEELAQKIKGYQE 5793

Query: 3004 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3063
             + S     K LTM       L  +     LA+              GT D+  ++    
Sbjct: 5794 QIASLNSKCKMLTMKAKHATMLLTVTEVEGLAE--------------GTEDLDGELLPTP 5839

Query: 3064 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3123
              H ++      +C  L + +      + T  E+ S  A       S +PV     ++ +
Sbjct: 5840 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPA-----CRSPSPVANTDASVNQ 5894

Query: 3124 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLV-GIKRDLEALSKQCNKLLDR 3182
                  A+ + L A     D A        + E   P L       L  L +    L + 
Sbjct: 5895 DI----AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNV 5950

Query: 3183 AQAREEQVEGTIKRLEEFYSKLKEFS-----ILLQKAEEHEESQGPVGMETETINQQLNM 3237
               ++  +   ++R +++   L+  S     I L+ +E  E  + P   E++    Q  M
Sbjct: 5951 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ESQMAEHQALM 6007

Query: 3238 FKVFQ-KEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ--GLEHDLDDVNARWKTLNKKV 3294
             ++   ++EI  LQ        L + L+  + ++   +   L+  L  +  R  T+  K 
Sbjct: 6008 DEILMLQDEINELQSS------LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKA 6061

Query: 3295 AQRAAQLQEAL---LHCGRFQDALE-------SLLSWMVDTEELVANQKPPSAEFKVVKA 3344
            + +   L+E L   L   R + AL+        L SW++ T+  +     P  E   ++A
Sbjct: 6062 SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA 6121

Query: 3345 QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAE 3404
            Q         L+D +   VE+                KV  L +LS+ +     L  KA 
Sbjct: 6122 Q---------LMDCQNMLVEI--------------EQKVVALSELSVHNENL-LLEGKAH 6157

Query: 3405 TRN---------RQLEGISVVAQQ-FHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQ 3454
            T++         R+L+G  +  Q+  H+  + LN   T  EK   + +   TQ+  ++E 
Sbjct: 6158 TKDEAEQLAGKLRRLKGSLLELQRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEW 6215

Query: 3455 IAQHKAL----EDDIINHNKHLHQAVSIGQSL-KVLSSREDKDMVQSKLDFSQVWYIEIQ 3509
            +AQ +          +   K L Q ++  +SL + ++SR ++ ++Q           E  
Sbjct: 6216 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA-------AETS 6268

Query: 3510 EKSHSRSELLQQALC--NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3567
              +  + ++L Q L     K   ED++  M W   +H        Q++ST+    Q + L
Sbjct: 6269 GDAGEKPDVLSQELGMEGEKSSAEDQMR-MKW-ESLH--------QEFSTKQKLLQ-NVL 6317

Query: 3568 RVLQEDILLRKQNVDQALLNGLELLK-QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
               QE +L  + N    LL+G+ L K      +   +   L+ +   +++++  S    +
Sbjct: 6318 EQEQEQVLYSRPN---RLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6374

Query: 3627 TLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNN 3686
               Q++ L ++L+       TWLD VE  L  +    L  EE        + L K+ K  
Sbjct: 6375 ---QSIHLEQKLYDGVSATSTWLDDVEERL--FVATALLPEETETCLFNQEILAKDIKEM 6429

Query: 3687 KALLD-SLNEVSSALLELVPWRAREGLEKMVAEDN-----ERYRLVSDTITQKVEEIDAA 3740
               +D + N  S A  E        G  + V ED       R  L+   + Q+  ++   
Sbjct: 6430 SEEMDKNKNLFSQAFPE-------NGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKER 6482

Query: 3741 ILR--------------------------SQQFDQAADAELSWITETEKKLMSLGDIRLE 3774
            + +                          +  F+Q    ++  I + E  L       +E
Sbjct: 6483 LQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6542

Query: 3775 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3834
              +   +LQV++    E+ + +D+ D+L+       +  ++    ++K + ++ L++   
Sbjct: 6543 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQN--LTLKSQYERALQDLAD 6600

Query: 3835 ICQINSERYL--------QLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3886
            + +   E+            E  Q L+++  E ++ L   +  T+++  ++ + A++ ET
Sbjct: 6601 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET 6660

Query: 3887 L----------------------------------RQQQEEHRQLRE---------LIAE 3903
                                                 QQE  RQL           L+ E
Sbjct: 6661 QFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6720

Query: 3904 HKPHI-----------DKMNKTGPQLLE-LSPGEGFSIQEKYVAADTLYSQIKE------ 3945
            ++  +             +N+  P+L + L  G+   I       ++  +Q+ E      
Sbjct: 6721 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNT 6780

Query: 3946 -DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL----RQPPSISAEVEKIKEQIS 4000
              + K    L+  +   T++  +   ++  L+   +RL    +Q  ++  E+E +++ ++
Sbjct: 6781 NKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLN 6840

Query: 4001 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4060
                 S +++    L  ++   G +++       K +    ++ +L ++   W ++ T +
Sbjct: 6841 AFLEFSKEVDAQSSLKSSVLSTGNQLLRL-----KKVDTATLRSELSRIDSQWTDLLTNI 6895

Query: 4061 EEREAKL--LDVMELAEKFWCDH-MSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET 4117
               + KL  L + +L  +      MS I  +++      D     I    + +  +  + 
Sbjct: 6896 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6955

Query: 4118 IREEIDGLQEELDIV----INLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4173
             + +I+  Q  +D V    + + S+ + +    DK    + +  +N +W  L     ++I
Sbjct: 6956 FKIDINCKQLTVDFVNQSVLQISSQDVES-KRSDKTDFAEQLGAMNKSWQILQGLVTEKI 7014

Query: 4174 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4233
              LE  +++  +Y++ +Q +  W +    +L     IG D  +V+  +++ +  +     
Sbjct: 7015 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKA 7073

Query: 4234 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4293
            ++ E+E++      L++   E+     V   L EL   W +L+  +   +  L+  L   
Sbjct: 7074 KEKEVEKIEQNGLALIQNKKEDVSS-IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQW 7132

Query: 4294 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4353
               + A D++ ++L      LS  + + G  +A+++++     LQ+D+   + +++    
Sbjct: 7133 SSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGS 7192

Query: 4354 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR---QAKGFHGEIE 4410
              N L++         L N L+ +N RW N+LE+  ++ Q     L+   + K +  +  
Sbjct: 7193 ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCA 7252

Query: 4411 DLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKS----LMQKGQQ 4466
               Q   D    LL +       + A +++   ++ C        T K     L + G+Q
Sbjct: 7253 STVQQQEDRTNELLKAATN---KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7309

Query: 4467 MLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLT 4526
            +  +   SA + I  D  +L +   ++E  L +++T L+  +     F  SL+    W+ 
Sbjct: 7310 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7369

Query: 4527 QAEQTLNVASRP-SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDV 4585
            +AE+ L       S  L T+  +++E K    + +S    +  L++ G  L      +++
Sbjct: 7370 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEI 7427

Query: 4586 VLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL 4645
              ++NL       W  +  +  ER   L     + + F E     ME+L ++E+ L   +
Sbjct: 7428 KRMQNL----NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AV 7481

Query: 4646 EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSEL 4705
            EI+ +   +  Q   H+ FQ  + ++  +  +    G+ L E+  + DD  + +  L+ L
Sbjct: 7482 EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLL 7540

Query: 4706 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP-QLAEDQPVHGDIDLV 4764
             ++W  +  ++ +R+  ++  +    ++ +  + L  WL  V    ++    V   +   
Sbjct: 7541 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7600

Query: 4765 MNLIDN----HKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETV 4820
              L D      K F ++ G    +V+A K+    L+       + ++ ++ E+  +W++ 
Sbjct: 7601 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQL---LLSADSGAEAALQAELAEIQEKWKSA 7657

Query: 4821 CALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHK 4880
                  ++ +L   L+  E+    +   LE L   ++ L     LPD  + L     + K
Sbjct: 7658 SMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQMRCK 7715

Query: 4881 EFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRL 4940
            E    +     +L + + + DT+ A    D I+ +   + +++ ++EE+       +Q++
Sbjct: 7716 ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQI 7775

Query: 4941 ASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRK 5000
               L       E  + L  WL   E+ ++     +I + IE++K      + + EE+   
Sbjct: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIA 7829

Query: 5001 QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNPRVN 5060
            Q +  ++ +  +R A       SH                         ++IE K  +VN
Sbjct: 7830 QENKIQLQQMGERLAK-----ASH---------------------ESKASEIEYKLGKVN 7863

Query: 5061 LLVSKWQQVWLLALERRRKLNDALDRLEEL 5090
                +WQ +  L   R +KL + L  +++L
Sbjct: 7864 ---DRWQHLLDLIAARVKKLKETLVAVQQL 7890



 Score =  317 bits (812), Expect = 2e-85
 Identities = 750/4057 (18%), Positives = 1540/4057 (37%), Gaps = 494/4057 (12%)

Query: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320
            +++A  + E+ + +   ++  ++ +E +     ++   +  L  WI + E     ++ + 
Sbjct: 1417 QQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETS- 1475

Query: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKM----DECQKYAEQY----SATVKDYELQTMTY 1372
               S  +  Q++Q K+ + EIE K S +    +E Q +A+      SA +K    Q   Y
Sbjct: 1476 ---SSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRY 1532

Query: 1373 R---------------AMVDSQQKSPVKRRRMQSSAD--------------------LII 1397
                              +  QQK     R++Q S                       ++
Sbjct: 1533 GEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVL 1592

Query: 1398 QEFMDLRTRYTALVTLMTQYIKFAGDSLKR--LEEEEKSLEEEKKEHVEKAKELQKWVSN 1455
            QE MDL     +L + +T +   A   + R    +E  +L+++ ++ + +AKE Q  + N
Sbjct: 1593 QEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALEN 1652

Query: 1456 ISKTLKDAEKA------------GKPPFSKQKISSEEISTKKE-QLSEALQTIQLFLAKH 1502
            +    +  EK              K    +  IS++ +  + E QL +ALQ   +  A  
Sbjct: 1653 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1712

Query: 1503 GDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQT------SGDVKVEEKIVAERQ 1556
              K+   + +      K   +   L     L+QL E         +  +   + +VAE Q
Sbjct: 1713 YSKLLQLKESLFSVASKDDVKMMKL----HLEQLDERWRDLPQIINKRINFLQSVVAEHQ 1768

Query: 1557 QEYKEKLQG--------ICDLLTQTENRLIGHQEAFMIGD---GTVELKK--YQSKQEEL 1603
            Q + E L          + +L T +E  ++ HQ A          VE KK   QS Q  L
Sbjct: 1769 Q-FDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHL 1827

Query: 1604 QKD-----------MQGSAQALAEVVKNTENFLKENGEKLSQ-----EDKALIEQKLNEA 1647
             K            +QG A+   ++ +     ++     LS      +  A +   L + 
Sbjct: 1828 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1887

Query: 1648 KIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDS 1707
            +   E  N   +     ++K +  A++      +A   L+   +K +  L   S+  + S
Sbjct: 1888 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1947

Query: 1708 ERAGTKH-----KQVIEQNGTHFQEGDG----KSAIGEEDEVNGNLLETDVDGQVGTTQE 1758
             RA         +++    GT   E D     K A  ++ E    LL++  D +  T +E
Sbjct: 1948 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE---ELLKSIEDIEERTDKE 2004

Query: 1759 NLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEE---KEKLQKNMKELK 1815
             L +  ++   Q  ++ +Q +  + + +     L+ + + ++ ++     ++ + +  L+
Sbjct: 2005 RLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLE 2064

Query: 1816 VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMT 1875
            V ++          +L H  Q +         E+++      + LEN    A  +    T
Sbjct: 2065 VTWDDT-------KRLIHENQGQCCGLIDLMREYQNLKSAVSKVLEN----ASSVIVTRT 2113

Query: 1876 KLKRQKSFSEDVISHKG----------DLRYITISGNRVLEAAKSCSKRDGGKVDTSATH 1925
             +K Q+        H+           DL   T  G  +L   K     D   V T    
Sbjct: 2114 TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMES 2173

Query: 1926 R-----EVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1980
                  +V  KL+   DR R   S  +       D++      E  S   +  +    + 
Sbjct: 2174 TVDKWLDVSEKLEENMDRLRVSLSIWD-------DVLSTRDEIEGWSNNCVPQMAENISN 2226

Query: 1981 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2040
               HL            R  E  K  + ++ ++ + +E+L      L +   +L     D
Sbjct: 2227 LDNHL------------RAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPD 2273

Query: 2041 IQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV 2100
            +Q    D++ + E   +        L+    +S  V+  ++++  W   VE SL    Q 
Sbjct: 2274 LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ- 2332

Query: 2101 PLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSAR 2160
              N T   + + K   +++++  +QS+I++  E +         +   SL   M  L  +
Sbjct: 2333 --NETC--EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2388

Query: 2161 FSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKD-VTELSQY 2219
                S    +T A ++E   K    E++ E  + FL  K  A    D  G   V E   +
Sbjct: 2389 HEAVSQLCSKTQASLQESLEK-HFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2447

Query: 2220 -MQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKK 2278
             +Q       + +  L+ +    + + +H      + + E+    +++F+       + K
Sbjct: 2448 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2507

Query: 2279 EAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLK 2338
            +A+  C  +L +F+   + L  WI E  ++       F  E+LG+S +   +       K
Sbjct: 2508 QALQDCASELGSFEDQHRKLNLWIHEMEER-------FNTENLGESKQHIPE-------K 2553

Query: 2339 TPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIK 2398
              E+ KV    + L  L++A     +++  +   G +L+ EG     E    ++ LTS  
Sbjct: 2554 KNEVHKVE---MFLGELLAA----RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS-- 2604

Query: 2399 KDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPA 2458
                     +++L  + K+K+      L + +  +E   +M  W++ +       + T  
Sbjct: 2605 ---------HQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLG 2655

Query: 2459 PTDTEAVKTQVEQN---KSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTE 2515
              DT   +    Q+      E E+K N+  + + +  L    +E     +       L  
Sbjct: 2656 SKDTLEKRLSQIQDILLMKGEGEVKLNM-AIGKGEQALRSSNKEGQRVIQT-----QLET 2709

Query: 2516 IDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNML 2575
            +   W ++   ++  Q  LE   +    +   + QL+QW+   +  +    PL   P + 
Sbjct: 2710 LKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQPQPGLK 2767

Query: 2576 N--TQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2633
                    +Q +L E         +L A  + +  +  ED S +   +E+L   TQ  D 
Sbjct: 2768 EKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKT-EDESFKDTAQEELK--TQFNDI 2824

Query: 2634 LTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETA 2693
            +T    ++   +++ +     Y   +   +D L     +L     +S    A  ++L   
Sbjct: 2825 MT-VAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS-- 2881

Query: 2694 QKMKQEIQQEKKQIKVAQ-ALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVE 2745
             K+K+ I  + ++I  ++ +  E L+  VK+       E +  E+ + L    K ++D  
Sbjct: 2882 -KIKELI--DSREIGASRLSRVESLAPEVKQNTTASGCELMHTEM-QALRADWKQWEDSV 2937

Query: 2746 QKAENHVQHLQSACASSHQ--------FQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLE 2797
             + ++ +++L S  A S Q         +Q    F A L T  ++          L +LE
Sbjct: 2938 FQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ----------LTLLE 2987

Query: 2798 SLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQV 2857
                D +        Q  +     AE     LK+Q +E       L+T         K+ 
Sbjct: 2988 GKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3047

Query: 2858 -----------KERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGEN 2906
                       + +E  L++   KA +  +Q      W+   +    +   C D  +  +
Sbjct: 3048 NCLCLQASKGCQNKEQILQQRFRKAFRDFQQ------WLVNAKITTAK---CFDIPQNIS 3098

Query: 2907 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQ-- 2963
             ++   SLQK + +     E   +  N +LS  E+   ++T E    IQ KV    E   
Sbjct: 3099 EVST--SLQK-IQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWK 3155

Query: 2964 -----LHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDS---LGSQAYSNKYL 3015
                 LH K+  LEN+  + K+F EVS E  +      E++ +H+S   L       +  
Sbjct: 3156 NFHSNLHQKESALENLKIQMKDF-EVSAEPIQDWLSKTEKM-VHESSNRLYDLPAKRREQ 3213

Query: 3016 TMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDE 3075
              LQ+  + +   + Q++  K  AQ L    + SK       +V  ++ ++  LS    E
Sbjct: 3214 QKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRH---RVSQLSSQYLALSNLTKE 3270

Query: 3076 KCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKL 3135
            K S L+  +     F   I+E+     +    LDS      D   L  +         KL
Sbjct: 3271 KVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRT-------LKL 3323

Query: 3136 EALMASNDNANKTCKMMLATEE-----TSPD-LVGIKRDLEALSKQCNKLLDRAQAREEQ 3189
            EAL++         KM++   E     TSP+ +  I++ L+++      LL      + Q
Sbjct: 3324 EALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQ 3383

Query: 3190 VEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3249
            +EG + +   +   +++FS  +   E +         E       L   K+   EE+   
Sbjct: 3384 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLN-EEVLSY 3442

Query: 3250 QGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCG 3309
                + +   G G+       T     + +L D+  R++ + ++  +   + ++ +    
Sbjct: 3443 SSLLETIEVKGAGM-------TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQ 3495

Query: 3310 RFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKRE 3369
             +Q  L++   W+   +E +        +    +  +++ + LQ    + ++ +  +   
Sbjct: 3496 EYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHT 3555

Query: 3370 GEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNE 3429
             E +  +  P  + + L+ L      W+A  ++      Q   +    +   +  + ++E
Sbjct: 3556 REDVIPSGIPQAEDRALESLR---QDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDE 3612

Query: 3430 WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSRE 3489
            WL T E+++       +  +  E Q+ Q K   +++  +   + +  +  Q +       
Sbjct: 3613 WLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEIL------ 3666

Query: 3490 DKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM-----------N 3538
            D+  V S++        +  + +     LL Q L   K F E+E++ +           +
Sbjct: 3667 DESHVNSRMG------CQATQLTSRYQALLLQVLEQIK-FLEEEIQSLEESESSLSSYSD 3719

Query: 3539 WLNEVHDKLSKLS--VQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTT 3596
            W    H     ++  +    T  + K+   L VL +D+      +  A   G   +K   
Sbjct: 3720 WYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLE 3779

Query: 3597 GDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVEL 3656
              E   ++ ++     + K++T        TLE+ L LA+      + L  W+ + +  L
Sbjct: 3780 EGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL 3839

Query: 3657 LSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMV 3716
               E   ++  E      + K L++   +++  + S+ E   ALLELV       L+  +
Sbjct: 3840 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQ---DVTLKDKI 3896

Query: 3717 AEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQD 3776
             +    Y+ +     + V  ++A +   + ++        W+ +   +L++   +     
Sbjct: 3897 DQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSL 3956

Query: 3777 QT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK----N 3831
            +T + QL   K    EI   +D +++L   G  ++  C++  +  +K+ +   L+    +
Sbjct: 3957 ETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDS 4016

Query: 3832 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPAL-------EY 3884
            Y  IC      Y  LE          +T ++   WL+  Q  +   P P L       + 
Sbjct: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076

Query: 3885 ETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL---YS 3941
            +  R  QE+ R   +L+       +   KT  + ++ +     +I++K V A  L   + 
Sbjct: 4077 KHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWE 4133

Query: 3942 QIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISE 4001
            +IK    +  + L +A           DQ L++++R    L        E+   +  +S+
Sbjct: 4134 EIKHLKSELWIYLQDA-----------DQQLQNMKRRHSEL--------ELNIAQNMVSQ 4174

Query: 4002 NKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVE 4061
             K+    ++  Q    T+ ++  ++  +    +     K +    DQ + +    + L  
Sbjct: 4175 VKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEH----KEINHLNDQWLDLCRQSNNLCL 4230

Query: 4062 EREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIR----DLEDPGIDPSVVKQQQEAAET 4117
            +RE    D+    +   C ++  +   K T ++      D E   +    +K+   A + 
Sbjct: 4231 QREE---DLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE 4287

Query: 4118 IREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLE 4177
             +  I+ L+++         ++I      DK +VK+    L   W  L    K +I    
Sbjct: 4288 RKYAIEDLKDQKQ-------KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSV 4340

Query: 4178 EAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIE 4237
              ++     Q   Q + +W +     +A                E LKQ       Q + 
Sbjct: 4341 TNLEELNVVQSRFQELMEWAEEQQPNIA----------------EALKQSPPPDMAQNLL 4384

Query: 4238 MERLNHQAEL-----LLKKVTEESDK----------HTVQDPLMELKLIWDSLEERIINR 4282
            M+ L   +EL     LLK + +++D+            +Q  L + +   + L + +  R
Sbjct: 4385 MDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQR 4444

Query: 4283 QHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVL 4342
            +  L  AL    QF  A+ +  + +   E  +  ++ +   P  +  ++      Q  + 
Sbjct: 4445 RKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLK 4504

Query: 4343 AHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQA 4402
             +Q+ V  +   G +L++    +E S +  KL+ L   + +VL+K   R Q+L+  L   
Sbjct: 4505 TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4564

Query: 4403 KGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ 4462
            K F  + +    WL   +        L         QL  +  +       E    +L +
Sbjct: 4565 KHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQR 4624

Query: 4463 KGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522
             GQ +L    +   + + + +N L  ++  +     ++  K++EA+    E+ + ++   
Sbjct: 4625 TGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTT 4684

Query: 4523 NWLTQAE-QTLNVASRPS-LILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS 4580
              L++ E Q L ++  P+ L ++  L   D  +   +EV    E + EL++     +   
Sbjct: 4685 QSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTG 4744

Query: 4581 QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS 4640
            Q        + ++ + + + ++ ++  +R   L+D    A Q HE   K+ + LE   KS
Sbjct: 4745 QPWQ----PDKMLHLVTLYHRLKRQTEQRVSLLEDTTS-AYQEHE---KMCQQLERQLKS 4796

Query: 4641 LDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNL---- 4696
            +  E    N+    +T  A+ K     L   HS+  +   +G  LK  T   +D      
Sbjct: 4797 VKEEQSKVNE----ETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD 4847

Query: 4697 -----KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4751
                 K    +   + +   +     E   + E  ++ S  F   +   +DWL RV+ +L
Sbjct: 4848 PLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAEL 4907

Query: 4752 AEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD-DSSWVKV 4808
            +   PV+ D++L  +   I   +  Q+E+      + AL    +E    +++  S+ ++ 
Sbjct: 4908 SG--PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEH 4965

Query: 4809 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4868
             + ELS     +     ++Q  L     Q + ++ V  A  +WL +A++ L+  G   D 
Sbjct: 4966 SLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDV 5025

Query: 4869 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEE 4928
            E A   L   H EF    ++  + L +  ++  T+  +  P             +   E+
Sbjct: 5026 ESAEENL-KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTG-----------KEDLEQ 5073

Query: 4929 VLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIA 4988
             +A  +   QR++       A+ +LL+   A  QW +     K +E + + + + +  ++
Sbjct: 5074 KVASLELRSQRMSRDSG---AQVDLLQRCTA--QWHDY---QKAREEVIELMNDTEKKLS 5125

Query: 4989 EHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS 5048
            E   F    T    + ++    +K   +  +S    I  L++         AS L  +G+
Sbjct: 5126 E---FSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEE--------KASQLEKTGN 5174

Query: 5049 QTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALD 5085
                 T +  +  +  +W ++  +A ++ + L DA+D
Sbjct: 5175 DASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5211



 Score =  303 bits (776), Expect = 3e-81
 Identities = 735/4084 (17%), Positives = 1585/4084 (38%), Gaps = 481/4084 (11%)

Query: 1112 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1169
            ++++LE+ KD L         F    +  + + +P    +L  + +  + V S S  ++ 
Sbjct: 442  IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 501

Query: 1170 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKR 1226
            K++ + L   +L     AE+ +K +  K    E+V   +  ++N +S +        E  
Sbjct: 502  KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---EQLLQNYVSFI--------ENS 550

Query: 1227 QVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVE-------RWQNVHVQID 1279
            + F   E        ++ ++ K   E  +  D   E+A+ +++       +W+N+ V++ 
Sbjct: 551  KFFEQYE--------VTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVR 602

Query: 1280 NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1339
            +    LE +  +   Y +T   L  W++  E        NQ EN+K    + N    +  
Sbjct: 603  SVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-----NQSENAKKDFFR-NLPHWIQQ 656

Query: 1340 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSSADLI 1396
               M  +     +   E  S  +K   L       +++ + +     VK+       D +
Sbjct: 657  HTAMNDAGNFLIETCDEMVSRDLKQQLL-------LLNGRWRELFMEVKQYAQADEMDRM 709

Query: 1397 IQEFMDLRTRYTALVT----LMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKW 1452
             +E+ D     +A  T     +++ ++ +  ++K L ++ + +E+       + K + K 
Sbjct: 710  KKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKT 769

Query: 1453 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1512
               I+K  +  ++ GK  F+      E+++  KE  S  L   Q  L             
Sbjct: 770  AHLITK--ESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIP---------LE 818

Query: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
            ELEKQ+ +  +S   +        +E+Q+S   K + + +   Q+  K+ L         
Sbjct: 819  ELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLT-------- 870

Query: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQK-DMQGSAQALAEVVKNTENFLKENGEK 1631
                        +I  G+  ++K+ +    L+  D     + +A++    ++ +K+ G+ 
Sbjct: 871  ------------LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDW 918

Query: 1632 LSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKT 1691
                 K  +E           +L  K E+S+ EL+KV+  A +E  E+    ++L    T
Sbjct: 919  -----KKHVETN--------SRLMKKFEESRAELEKVLRIA-QEGLEEKGDPEELLRRHT 964

Query: 1692 KIENLLD------WLSNVDKDSERAGTKHKQVIEQ--NGTHFQEGDGKSAIGEEDEVNGN 1743
            +  + LD      +L   D+ ++    + +Q +++     H Q  D       + E   +
Sbjct: 965  EFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD------LQGEAPYH 1018

Query: 1744 LLETDVDGQ----VGTTQENLNQQYQKVKAQ----HEKIISQHQAVIIATQSAQVLLEKQ 1795
            LL   +D +    + + +E   +  ++ K       EKII +H+ V  + +    L EK+
Sbjct: 1019 LLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHR-VFFSDKGPHHLCEKR 1077

Query: 1796 GQYLSPEE---KEKLQKNMKELKVHYETALAESEKKMKLTH-SLQEELEKFDADYT---- 1847
             Q +  EE   K  ++  +++        L E    +  T+  L E+ +K+  DYT    
Sbjct: 1078 LQLI--EELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK-DYTSRFS 1134

Query: 1848 EFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1907
            EF  W+  +E +L+ ++  A D      ++KR      + ++ +G+      S  +VL  
Sbjct: 1135 EFSSWISTNETQLKGIKGEAID-TANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193

Query: 1908 AKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1967
              S         + +    +   KL  +     +L S+   + +N  D V   +  +++ 
Sbjct: 1194 VSS--------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSL 1245

Query: 1968 CGLLAGLQACEATASKHL-SEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEV 2026
              L++G +  +  A K L +E +    + L    ++TK +  +    Q  + + ++    
Sbjct: 1246 EELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1305

Query: 2027 LLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDW 2086
            L D     L     ++ TLD        L +S   +  ++Q+TL +    +   + ++ +
Sbjct: 1306 LPDRGHEEL---RKLESTLD-------GLERSRERQERRIQVTLRKWERFETNKETVVRY 1355

Query: 2087 MGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEK-VKKFME-TTDP 2144
            +    SS +      L+ ++L+  +S  +   ++ + R  SI    E  VK+  E    P
Sbjct: 1356 LFQTGSSHERF----LSFSSLES-LSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGP 1410

Query: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALT 2204
                 LQ + K +  +  +     +E +  ME +KTK + F +  E L  ++  K + L 
Sbjct: 1411 QNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELN 1470

Query: 2205 EVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLS 2264
             ++     +      ++ +  E       +  L    +  +      + A +  K   + 
Sbjct: 1471 ALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIR 1530

Query: 2265 KKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKS 2324
            +  +E+ +  +  +  +     Q   F+  ++ ++  + E                    
Sbjct: 1531 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSE-------------------- 1570

Query: 2325 LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATN 2384
             ED   +  K      E  KV    + LC  + ++++   A +A  S   V+N +     
Sbjct: 1571 FEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSA--SARKVVNRD----- 1623

Query: 2385 TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQ 2444
                       S  ++   +   YED+    K++   L   L+  Q+ ++E S+ + WL+
Sbjct: 1624 -----------SCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLE 1672

Query: 2445 KMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTP 2504
            +    A+  +      D  A + +VE        L+  V        KL +L E      
Sbjct: 1673 RGEAKASSPEM-----DISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVA 1727

Query: 2505 EAPRWKQM---LTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2561
                 K M   L ++D +W++L Q+   R   L+       QF  +      W+      
Sbjct: 1728 SKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSE 1787

Query: 2562 VSVLGPLSIDPNMLNTQRQ-----QVQILLQEFATRKPQYEQLTAAGQG----ILSRPGE 2612
            +     +SI  + +   R      +V+    E  + +    +L + G+     +L    E
Sbjct: 1788 LQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAE 1847

Query: 2613 D-----------PSLRGIVKEQLAAVTQKWDSLTGQL--------------SDRCDWIDQ 2647
            D              R +    LA   Q   SL+G L               +  D I++
Sbjct: 1848 DCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEK 1907

Query: 2648 AIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI 2707
             +  + Q    L S +  L  + +K    L + +     + +  TA ++  E+++ +  +
Sbjct: 1908 DLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCR-ATADQLCGEVERIQNLL 1966

Query: 2708 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2767
               Q+  + L+       LK     Q E +LKS +D+E++ +   + L+    +    QQ
Sbjct: 1967 GTKQSEADALAV------LKKAFQDQKEELLKSIEDIEERTDK--ERLKE--PTRQALQQ 2016

Query: 2768 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 2827
              R F    D   E  +  H +    D  + + +    F+  +  + +  E T  + + L
Sbjct: 2017 RLRVFNQLED---ELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRL 2073

Query: 2828 LLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2887
            + + QG     + L               ++E +N LK ++ K L+    V      I  
Sbjct: 2074 IHENQGQCCGLIDL---------------MREYQN-LKSAVSKVLENASSVIVTRTTI-- 2115

Query: 2888 CQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFG----MVELLNNTANSLLSVCEIDK 2943
               + E++K+    ++ E +  K+   QK++D        ++  L    +S  S+ + D 
Sbjct: 2116 --KDQEDLKWAF--SKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDM 2171

Query: 2944 EVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHD 3003
            E   D+   + +K++   ++L       +++     E +  S     Q+      LD H 
Sbjct: 2172 ESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNH- 2230

Query: 3004 SLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIA 3063
             L ++    ++ + ++ +   L+ L  +V+  K L ++L          +D++ ++E  A
Sbjct: 2231 -LRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEH-A 2288

Query: 3064 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3123
            +E + +++   +  +   T++      +  I ++ + F + ++ L + A      E L+K
Sbjct: 2289 KEITEVAKGTLKDFTAQSTQV------EKFINDITTWFTKVEESLMNCAQ-NETCEALKK 2341

Query: 3124 QKETIKAFLKKLEALMASNDNANKTCKMMLATEETS--PDLVGIKRDLEALSKQCNKLLD 3181
             K+  K    +   + ++ +N N  C+   + E  S    + G+ +  EA+S+ C+K   
Sbjct: 2342 VKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQA 2401

Query: 3182 RAQ-AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV 3240
              Q + E+    +++  +E++   K        A+E  +  G   +    ++   N+   
Sbjct: 2402 SLQESLEKHFSESMQEFQEWFLGAK------AAAKESSDRTGDSKVLEAKLHDLQNIL-- 2453

Query: 3241 FQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQ 3300
               + +   Q K   V   GQ L    +K      ++  +   N  ++   K+  +    
Sbjct: 2454 ---DSVSDGQSKLDAVTQEGQTLYAHLSKQI-VSSIQEQITKANEEFQAFLKQCLKDKQA 2509

Query: 3301 LQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL---LQRLLD 3357
            LQ+     G F+D    L  W+ + EE    +    ++  + + + +  K+   L  LL 
Sbjct: 2510 LQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLA 2569

Query: 3358 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3417
             R+S ++ + + G+ ++     A +   L    L   +    + K + R+ Q      VA
Sbjct: 2570 ARES-LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ------VA 2622

Query: 3418 QQFHETLEPLNE----WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNK--- 3470
             Q HE LE   +    W+  I+ RL   E        LE++++Q   ++D ++   +   
Sbjct: 2623 LQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ---IQDILLMKGEGEV 2679

Query: 3471 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3530
             L+ A+  G+     S++E + ++Q++L+  +  + +I   S      L+  +     + 
Sbjct: 2680 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2739

Query: 3531 EDEVELMNWLNEVHDKL-----------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3579
            E + +L  W+  V  K+            K  + D+    L + +   R L   I   ++
Sbjct: 2740 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE 2799

Query: 3580 NVDQALLNGLELLKQTTGDEVLI-IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3638
              ++      E  K T  +E+     D +   K + + + ++  D    L+   +    L
Sbjct: 2800 LYEK---TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856

Query: 3639 HSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3698
            HS  EEL  W D             + G+ ++         +K+    K L+DS  E+ +
Sbjct: 2857 HSAKEELHRWSD-------------MSGDSSA--------TQKKLSKIKELIDS-REIGA 2894

Query: 3699 ALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWI 3758
            + L  V   A E  +   A   E        +    ++ + ++ ++Q   +   ++++ +
Sbjct: 2895 SRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA-L 2953

Query: 3759 TETEKKLMSLGDIRLEQ--DQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHK---IMT 3811
            +E E    S    +LEQ  +Q SA L   KT+  +  +L  K+  +++V+  HK   I+ 
Sbjct: 2954 SEQE---FSGQVAQLEQALEQFSALL---KTWAQQLTLLEGKNTDEEIVECWHKGQEILD 3007

Query: 3812 AC--SEEEKQSMKKKLDK-----------------VLKNYDTICQINSERYLQLERAQSL 3852
            A   +E   + +K +L++                 ++K Y+ +C + + +  Q  + Q L
Sbjct: 3008 ALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLC-LQASKGCQ-NKEQIL 3065

Query: 3853 VNQFWETYEELWPWLTE---TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHID 3909
              +F + + +   WL     T +    +P    E  T  Q+ +E   L E  +E+  H  
Sbjct: 3066 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEF--LSE--SENGQHKL 3121

Query: 3910 KMNKTGPQLLE--LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 3967
             M  +  +LL   L+  +   IQ K  AA   +     ++ ++  AL+    Q   F   
Sbjct: 3122 NMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVS 3181

Query: 3968 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4027
             + I + L +  + + +  +   ++   + +  + ++V  ++   +P    LK++ +++ 
Sbjct: 3182 AEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL- 3240

Query: 4028 ARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVT 4087
                  +   ++K+ + ++ Q+   +  +  L +E+ ++L       ++   +H    + 
Sbjct: 3241 -----WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRL-------DRIVAEHNQFSLG 3288

Query: 4088 IKDTQDFIRDLE-------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4140
            IK+ QD++ D          P  D SV+  +    E +       + ++ +++  G  ++
Sbjct: 3289 IKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL 3348

Query: 4141 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4200
                    P +++ +  +   W SL  A      +LE A+     YQDG++    W+D  
Sbjct: 3349 QNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSM 3408

Query: 4201 GGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT 4260
               L        +L      + + K    E       +E +         K    ++ + 
Sbjct: 3409 EANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIE-------VKGAGMTEHYV 3461

Query: 4261 VQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPV 4320
             Q  L +L+  + +++ER      K E  +    ++Q  L     WL   +  L +   +
Sbjct: 3462 TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVL 3521

Query: 4321 GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4380
             GD    E  L     LQ      Q+ + +V     D+I S   +        LE L Q 
Sbjct: 3522 EGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALESLRQD 3578

Query: 4381 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL 4440
            WQ    +  + + Q +  + + +    + + + +WL   E  +           T + QL
Sbjct: 3579 WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQL 3638

Query: 4441 NV----HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496
            +     H EV A  +  EE    +  + Q++L        + +      L  +++++  +
Sbjct: 3639 HQMKKWHEEVTAYRDEVEE----VGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQ 3692

Query: 4497 LNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF--QIDEHK 4553
            + E+   LEE +    E  +SL  + +W     +   NVA++   + DTV+   ++   +
Sbjct: 3693 VLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV-DTVMMGKKLKTLE 3751

Query: 4554 VFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL 4613
            V   ++      +    + G     + ++ +   ++  +     + +++   + +   +L
Sbjct: 3752 VLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTL 3811

Query: 4614 DDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHS 4673
            +     AK+F +    L +W+ E ++ L    E   +  + K QL+++K  Q+++ +   
Sbjct: 3812 EKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEP 3871

Query: 4674 VYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4733
               +    G +L E       ++ L D + +L+  +  +C    E    LE  +     +
Sbjct: 3872 SVKSVREKGEALLELV----QDVTLKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDY 3927

Query: 4734 TDALQALIDWLYRVEPQL-AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSA 4792
               LQ +  WL ++  +L A D      ++ +   + +HKA  +E+      +  L+   
Sbjct: 3928 NSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKG 3987

Query: 4793 RELIEGSRDD-----SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHA 4847
              LI    D         V   +Q     +  +C+ +      LE  L++       +  
Sbjct: 3988 DTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQ 4047

Query: 4848 LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAIC 4907
               WL+  +  L      P  +  L        E +K+++  RA   +A T  D + ++C
Sbjct: 4048 CQAWLSAVQPDLE-----PSPQPPL-----SRAEAIKQVKHFRALQEQARTYLDLLCSMC 4097

Query: 4908 HPD--SITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAE 4965
                 S+ T    I       E+ L  A+   Q       G    + L   L  +LQ A+
Sbjct: 4098 DLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ-------GWEEIKHLKSELWIYLQDAD 4150

Query: 4966 TTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDV----DKVTKTYKRRAADPSSL 5021
              L +  +     E+   + ++++ + F++++  KQ  V    +KV K  K+  +     
Sbjct: 4151 QQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE 4210

Query: 5022 QSHI 5025
             +H+
Sbjct: 4211 INHL 4214



 Score =  296 bits (759), Expect = 3e-79
 Identities = 757/4370 (17%), Positives = 1680/4370 (38%), Gaps = 541/4370 (12%)

Query: 1030 SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ 1089
            S S +     ++ V  Q  +  L S    E+E   +  +++   + R++ +      + Q
Sbjct: 1475 SSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK------LTQ 1528

Query: 1090 IRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 1149
            IR   E    H      T    L ++ ++ +++L  I     EF  + A    + +  +E
Sbjct: 1529 IRRYGEELREHAQCLEGTILGHLSQQ-QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1587

Query: 1150 LNVVLQN----MNQVYSMSSTYIDKLKTVNLVLKN---TQAAEALVKLYETKLCEE---- 1198
               VLQ        + S+SS       +   V+      Q A AL + YE  L       
Sbjct: 1588 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1647

Query: 1199 ---EAVIADKNNIENLISTLKQW------------------RSEVDEKRQVFHALEDEL- 1236
               E ++A    +E  +S+   W                  R +V+ + Q+  AL++E+ 
Sbjct: 1648 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1707

Query: 1237 ------QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1290
                   K   + + +F    + D+     K   +QL ERW+++   I+ R+  L+ +  
Sbjct: 1708 SQASFYSKLLQLKESLFSVASKDDVKM--MKLHLEQLDERWRDLPQIINKRINFLQSVVA 1765

Query: 1291 SLKYYRDTYHPLDDWIQ----QVETTQR-KIQENQPENSKTLATQLNQQKMLVSEIEMKQ 1345
              + + +       WI+    +++TT    I ++Q          L + K   +E+E K+
Sbjct: 1766 EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ--------VALTRHKDHAAEVESKK 1817

Query: 1346 SKMDECQKYAEQYSATVKDYELQTMTYRA----MVDSQQKSPVKRRRMQSSADLIIQEFM 1401
             ++   Q +  +  +  +  +L  +  +A     +  +    V+RR++  S    + EF+
Sbjct: 1818 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH---LAEFL 1874

Query: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1461
                  + ++  + Q ++ A +S+ + E +   +E++  + ++ AK L+    ++   L 
Sbjct: 1875 QSHASLSGILRQLRQTVE-ATNSMNKNESD--LIEKDLNDALQNAKALESAAVSLDGILS 1931

Query: 1462 DAEKAGKPPFSKQKIS----SEEISTKKEQLSEALQTIQ-----LFLAKHG--------- 1503
             A+   K   S+Q+ S    ++++  + E++   L T Q     L + K           
Sbjct: 1932 KAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELL 1991

Query: 1504 ------DKMTDEER----------------NELEKQVKTLQESYNLLFSESLKQLQESQT 1541
                  ++ TD+ER                N+LE ++ + +     L  +  KQ+ +   
Sbjct: 1992 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWL-KDKAKQIAQKDV 2050

Query: 1542 SGDVKVEEKI---------VAERQQEYKEKLQGICDLLTQTEN------RLIGHQEAFMI 1586
            +   +V+ +I               E + +  G+ DL+ + +N      +++ +  + ++
Sbjct: 2051 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2110

Query: 1587 GDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ 1642
               T+    +LK   SK E  +  M    + L       ++ L E  +K+   D +L++ 
Sbjct: 2111 TRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL-KKIHSSDFSLVKT 2169

Query: 1643 KLNEAKIKCEQLNLKAEQSKKEL-------DKVVTTAIKEETEKVAAVKQLEESKTKIEN 1695
             +     K   ++ K E++   L       D V++T  + E      V Q+ E+ + ++N
Sbjct: 2170 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDN 2229

Query: 1696 -------LLDWLSNVDKDSERAGTKHKQVIEQN----------GTHFQEGDGKSAIGEED 1738
                   L ++ S V   + R    H +V +               F E D    +    
Sbjct: 2230 HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAK 2289

Query: 1739 EVNGNLLETDVDGQVGTTQ-----ENLNQQYQKVK------AQHE------------KII 1775
            E+      T  D    +TQ      ++   + KV+      AQ+E            K +
Sbjct: 2290 EITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKEL 2349

Query: 1776 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1835
               Q+ I +TQ     L    +     E E L + M  L   +E   A S+   K   SL
Sbjct: 2350 QSQQSNISSTQEN---LNSLCRKYHSAELESLGRAMTGLIKKHE---AVSQLCSKTQASL 2403

Query: 1836 QEELEK-FDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDL 1894
            QE LEK F     EF+ W   ++   +       D   L  KL   ++  + V   +  L
Sbjct: 2404 QESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2463

Query: 1895 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1954
              +T  G  +             ++ +S     +Q ++  A + F++   +C      L+
Sbjct: 2464 DAVTQEGQTLYAHLSK-------QIVSS-----IQEQITKANEEFQAFLKQCLKDKQALQ 2511

Query: 1955 DLVDKYQHYEDASCGLLAGLQACEATAS-KHLSEPIAVDPKNLQRQLEETKALQGQISSQ 2013
            D   +   +ED    L   +   E   + ++L E     P+  + ++ + +   G++ + 
Sbjct: 2512 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK-KNEVHKVEMFLGELLAA 2570

Query: 2014 QVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRS 2073
            + +++KL +  + LL   G          +    ++  +++L +   E+    Q+ L   
Sbjct: 2571 RESLDKLSQRGQ-LLSEEGH---GAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2626

Query: 2074 LSVQDGLDEMLDWMGNVESSL--------------------------KEQGQVPLN---- 2103
             ++++ L  M  W+  ++  L                          K +G+V LN    
Sbjct: 2627 EALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIG 2686

Query: 2104 -----------------STALQ-------DIISKNIMLEQDIAGRQSSINAMNEK---VK 2136
                              T L+       DI+S ++  +  +    S  N   E+   ++
Sbjct: 2687 KGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLE 2746

Query: 2137 KFMETTDPSTASSLQAK---------MKDLSARFSEASHKHK---ETLAKMEEL--KTKV 2182
            ++ME+ D      LQ +         +  L +  SEA    +     +AK  EL  KT+ 
Sbjct: 2747 QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTED 2806

Query: 2183 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2242
            E F++ +++     E KTQ    + V  + + ++ + +++         +  + LHS  +
Sbjct: 2807 ESFKDTAQE-----ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKE 2861

Query: 2243 EISSHG-LPSDKALVLEKTNNLSK----------KFKEMEDTIKEKKEAVTS--CQEQLD 2289
            E+     +  D +   +K + + +          +   +E    E K+  T+  C+    
Sbjct: 2862 ELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHT 2921

Query: 2290 AFQVLVKSLKSW----------IKETTKKVPIVQPSFGAE--DLGKSLEDTKKLQEKWSL 2337
              Q L    K W          ++    ++ + +  F  +   L ++LE    L + W+ 
Sbjct: 2922 EMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQ 2981

Query: 2338 KTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEFWANKG-LT 2395
            +                L+    T  + +     G  +L+  +     TE+  +    L 
Sbjct: 2982 QL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELC 3027

Query: 2396 SIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2450
               +D++  S     L      L L+      N +    Q+ ++      QWL  +N   
Sbjct: 3028 RFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWL--VNAKI 3085

Query: 2451 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2510
            T  +    P +   V T +++ + F +E +   +K+  +  K  ELL       +A   +
Sbjct: 3086 TTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQ 3144

Query: 2511 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2570
              +T     W+  +     ++  LE     +  F+     ++ WL + E MV        
Sbjct: 3145 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLY 3204

Query: 2571 DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQK 2630
            D      ++Q++Q +L+E    +PQ  +L    Q +        S R     +++ ++ +
Sbjct: 3205 DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----HRVSQLSSQ 3260

Query: 2631 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2690
            + +L+    ++   +D+ + +  Q+   ++ L D ++D  + L S    ++    ++ + 
Sbjct: 3261 YLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRT 3320

Query: 2691 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2750
               + +    Q+++ Q+K+     E +      E +   + +QL+ +   +  +      
Sbjct: 3321 LKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIR 3379

Query: 2751 HVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTL 2810
                L+ A +    +Q   R F  W+D+ +   N+S    A+L    +++   K  ++ +
Sbjct: 3380 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEV 3439

Query: 2811 TAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEK 2870
             + S + E    +G  +      +E    QL+L  ++  +    ++ KE   K ++ +  
Sbjct: 3440 LSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRL 3493

Query: 2871 ALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQHFGMVELLN 2929
              +Y+  ++    W+ + Q  L++       A   E ++  L+ LQ    +   ++  + 
Sbjct: 3494 HQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVL 3553

Query: 2930 NTANSLL--SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2987
            +T   ++   + + +   +    +SL Q       +L   +    N+  K +  ++  ++
Sbjct: 3554 HTREDVIPSGIPQAEDRAL----ESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQ 3609

Query: 2988 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ-----KSLQALKHQVDLAKRLAQDL 3042
                L+ A+E++    S  ++  SN+    +Q  Q     + + A + +V+     AQ++
Sbjct: 3610 VDEWLKTAEEKV----SPRTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEI 3665

Query: 3043 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3102
            + E   S   S +  Q   +   +  L  QV E+  FLE ++Q +   ++++      + 
Sbjct: 3666 LDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYG 3722

Query: 3103 EFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKTCKMMLATE 3156
                   ++A      +T+   K+ +T++  LK +E     L ++ +   +  K +   E
Sbjct: 3723 STHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE 3782

Query: 3157 ETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEE 3216
                    +++++    +Q  +L    +     +E  +   +EF  K K  +  + + +E
Sbjct: 3783 AER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3837

Query: 3217 HEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGL 3276
                     ME      QL+ +K  Q+  +   +   + V   G+ L++     T    L
Sbjct: 3838 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH-EPSVKSVREKGEALLELVQDVT----L 3892

Query: 3277 EHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTE-ELVANQKPP 3335
            +  +D + + ++ L     +    L+  +     +   L+ +  W++     LVA     
Sbjct: 3893 KDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLE 3952

Query: 3336 SAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI----ATTAEPADKVKILKQLSL 3391
            ++  + +  Q+   K +   +   +  +  ++ +G+ +    A   +   K  +   L  
Sbjct: 3953 TSSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG 4012

Query: 3392 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKL 3451
                + A+ + A+   + LE          +TL+    WL+ ++  L          ++ 
Sbjct: 4013 TKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEA 4072

Query: 3452 EEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEK 3511
             +Q+   +AL++                       +R   D++ S  D S        + 
Sbjct: 4073 IKQVKHFRALQEQ----------------------ARTYLDLLCSMCDLSNASVKTTAKD 4110

Query: 3512 SHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR--- 3568
                 + ++Q L  A+   +   E+ +  +E+   L      D   + + ++ SEL    
Sbjct: 4111 IQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRRHSELELNI 4167

Query: 3569 ----VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTD 3623
                V Q    ++K    QA +N + E + + T  E      ++  +  ++ D+ + S +
Sbjct: 4168 AQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNN 4227

Query: 3624 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3683
            +    E+ LQ  R  H      C  + +V +E  + E   L   +A    +  + LKK A
Sbjct: 4228 LCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLA 4282

Query: 3684 ---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAA 3740
               +  K  ++ L +    ++E +    +E +++  +   +R+  + D I +K++ +   
Sbjct: 4283 LALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQ-VSVT 4341

Query: 3741 ILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDII 3799
             L      Q+   EL  W  E +  +          D     L        E+   + ++
Sbjct: 4342 NLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLL 4401

Query: 3800 DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWET 3859
              L+K   ++M      E+Q ++K L     + + +  +  +R   L +A S   QF   
Sbjct: 4402 KSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMA 4461

Query: 3860 YEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL 3919
              +    + + +  I       L  + + +Q +  +  +  +  ++  +  +   G +L+
Sbjct: 4462 VFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELM 4521

Query: 3920 -ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3978
             E++  E   +  K     ++Y  + +    R   L++ +     F +  D+    L++ 
Sbjct: 4522 KEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQA 4581

Query: 3979 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4038
                    ++  E  ++  Q+++ +N+     + + L  TL++ G+ ++      D    
Sbjct: 4582 DIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY- 4640

Query: 4039 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIKDTQ-DFIR 4096
               + +KL+ +   +  I  L +++  K+ + + LA K +   + L   ++ + +  F+R
Sbjct: 4641 ---LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLSELEAQFLR 4696

Query: 4097 DLEDPGIDPSVVK--QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKS 4154
              + P  D +V +    Q+    I +E+ GL E +D  +N   E   + G+P +P     
Sbjct: 4697 MSKVP-TDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPWQP---DK 4751

Query: 4155 IDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL 4214
            +  L + +  L +  + R+  LE+   A  +++   Q +   +     + + ++      
Sbjct: 4752 MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE----- 4806

Query: 4215 ETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTVQDPLMEL 4268
            ET+  + E+LK + S A   Q   I ++R+    E L   L  +  E  +H +Q    EL
Sbjct: 4807 ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGEL 4865

Query: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
            KL+  ++ E +   + ++  ++     FQ  +   L WL   +  LS    +  + + I+
Sbjct: 4866 KLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQ 4921

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4388
             E+ K  + Q +V +    + A++    +    +    +++L++ L  L++   ++ E  
Sbjct: 4922 EEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL 4981

Query: 4389 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQLNVHMEVC 4447
              R+  L     Q + ++   +    WL D +  L LA   L    E+A+E L  HME  
Sbjct: 4982 RTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKSHME-- 5037

Query: 4448 AAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETKLNERKTK 4503
              F + E+ + S +++   ++A        + + +++Q + +L+ + + +      +   
Sbjct: 5038 --FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDL 5095

Query: 4504 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEHKVFANEV 4559
            L+       ++  + ++ I  +   E+ L   S  SL+  +   +    + EHK   + V
Sbjct: 5096 LQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEHKALVSVV 5152

Query: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619
            NS  E+I+ L++  + L+          +   + +V  RW ++     ++ + L+DA   
Sbjct: 5153 NSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDE 5212

Query: 4620 AKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTN 4679
               F+    K  E +++ +  L           ++ T L  H  F   L  + S      
Sbjct: 5213 WTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLR 5272

Query: 4680 RTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFS 4730
            +   S+          E+  L  +   + D    +++K  T  GK V+++ K  E +   
Sbjct: 5273 QQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKDREMV--- 5328

Query: 4731 GQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK---------AFQK 4776
                  + ++  W+     Y   P +  D  +  ++ +++    NH+           +K
Sbjct: 5329 ---ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKMAEEQKEK 5384

Query: 4777 ELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
             LG  T      S+Q    AL    R+ I+    +    K   QELS + + +     + 
Sbjct: 5385 YLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5444

Query: 4828 QTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRTL 4875
             T+L+A                EE       L+E  A  ++ L  +G L       +  L
Sbjct: 5445 LTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKL 5504

Query: 4876 IDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQ 4935
             + H++ +++ E + ++LN+A +  +      + + +  I  WI   +      +AW   
Sbjct: 5505 TELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHGTIAWNSA 5559

Query: 4936 HQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---EIEEVKAL 4986
             Q R    L   + ++       LEA+   LQ+  +   T+K  + + +   E EE++ +
Sbjct: 5560 SQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQM 5619

Query: 4987 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5036
            I   +  ++ +     D+ K     K+  A     Q+ +   + GR   K
Sbjct: 5620 I---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5666



 Score =  293 bits (751), Expect = 2e-78
 Identities = 845/4654 (18%), Positives = 1779/4654 (38%), Gaps = 620/4654 (13%)

Query: 572  EPNSLQTLKLMQIRKPLLKSSLLDQNL---TEEEINMKFVQDLLNWVDEMQVQL---DRT 625
            +PN  + LK  Q   P +  +LL  +L   +E E     ++ L+   D +   L   +R 
Sbjct: 4364 QPNIAEALK--QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQ 4421

Query: 626  EWGSDLPSVESHL--------ENHKNVHRAIEEFESSLKEA--KISEIQMTAPLKLTYAE 675
                 L   +SH+        +  K +++A+ E    L       S+IQ     K+ + E
Sbjct: 4422 VIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHER-KIMFRE 4480

Query: 676  KLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIA 735
             +  L    +K + T ++ +  L T  N                  EV   W++      
Sbjct: 4481 HICLLPDDVSKQVKTCKSAQASLKTYQN------------------EVTGLWAQGR---- 4518

Query: 736  RKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 795
                   ELM+E+ ++E++     E+  +L                 +Q+ +  +LQ C 
Sbjct: 4519 -------ELMKEVTEQEKS-----EVLGKL---------------QELQSVYDSVLQKCS 4551

Query: 796  CVEQHIKENTAYFEFFN-DAKEATDYLRNLKDAIQRKYSC-DRSSSIH----KLEDLVQE 849
               Q +++N    + F  D  +A  +L+        + +  + SS +H    K ++++++
Sbjct: 4552 HRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ 4611

Query: 850  SMEEKEELLQYKSTIANLMGKAKTIIQ--LKPRNSDCPLKTSIPIKAICDYRQIEITIYK 907
            S E +  LL  + T   ++     +    L  + +  P + ++ +    D        YK
Sbjct: 4612 SPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKD------KFYK 4665

Query: 908  DDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWH 967
              E +LA   + +  ++ + + +E     +  +  P      DLA       +  L+L  
Sbjct: 4666 VQEAILARKEYASLIELTTQSLSELEAQFLRMSKVP-----TDLA------VEEALSLQD 4714

Query: 968  ESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQ 1027
                 +  V      ++E+++ +    ++ +   P +   +++ L  R    L+   E +
Sbjct: 4715 GCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVT-LYHR----LKRQTEQR 4769

Query: 1028 VFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE-NCEDRL 1086
            V    D T   +E     Q  +  LKS + E+ + +   L   E   +   L  + +D  
Sbjct: 4770 VSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSG 4829

Query: 1087 IRQIRTPLERDDLHESVFRITEQ------EKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
            I   R  +  +DL   +  +  +      +  + EL+ L   +G    +CE    Q+   
Sbjct: 4830 IVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSI-- 4887

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSS--TYID--------KLKTVNLVLKNTQAAEALVKL 1190
                  ++E++  L  + +V +  S   Y+D        +++ + +  +  Q++  ++  
Sbjct: 4888 ----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNA 4943

Query: 1191 YETKLCEE-----EAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDE 1245
               K  E+     E + AD   +E+ ++ L +   ++ E      AL         I  +
Sbjct: 4944 LSHKEKEKFTKAKELISAD---LEHSLAELSELDGDIQE------ALRTRQATLTEIYSQ 4994

Query: 1246 MFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDW 1305
              + Y+      DW ++  + L         Q+     D+E   ++LK + + +   D +
Sbjct: 4995 CQRYYQVFQAANDWLEDAQELL---------QLAGNGLDVESAEENLKSHMEFFSTEDQF 5045

Query: 1306 IQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY 1365
               +E     +    P    T    L Q+   V+ +E++  +M                 
Sbjct: 5046 HSNLEELHSLVATLDPLIKPTGKEDLEQK---VASLELRSQRMSRDSG------------ 5090

Query: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL 1425
                    A VD  Q+   +    Q + + +I+   D   + +    L T     A + L
Sbjct: 5091 --------AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5142

Query: 1426 KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1485
                 E K+L        EK   L++  S + KT  DA KA          S   +  + 
Sbjct: 5143 S----EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKA------TLSRSMTTVWQRW 5192

Query: 1486 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1545
             +L    Q  +  L    D+ T    N+++K  + + +  + L   S ++  +++    +
Sbjct: 5193 TRLRAVAQDQEKILEDAVDEWTGFN-NKVKKATEMIDQLQDKLPGSSAEKASKAELLTLL 5251

Query: 1546 KVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQK 1605
            +  +  V E +Q+             Q+   ++  Q   M+ DG         ++  L +
Sbjct: 5252 EYHDTFVLELEQQ-------------QSALGMLRQQTLSMLQDGAAPTP---GEEPPLMQ 5295

Query: 1606 DMQGSAQALAEVVKNTENFLKENGEKLSQE--DKALIEQKLNEAKIKCEQLNLKAEQSKK 1663
            ++     A+ +   N +  +K NG+ + QE  D+ ++E ++N  K   ++          
Sbjct: 5296 EIT----AMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI 5351

Query: 1664 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQV--IEQN 1721
            E+D                  QLEE +  +    +   N++K +E    K+  +  I  +
Sbjct: 5352 EIDA-----------------QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPS 5394

Query: 1722 GTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV 1781
                Q  +    +   D++   + E +   Q   T + L++Q QK+      I+++ +A 
Sbjct: 5395 ELSLQLAEVALDLKIRDQIQDKIKEVE---QSKATSQELSRQIQKLAKDLTTILTKLKA- 5450

Query: 1782 IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMK-LTHSLQEELE 1840
                ++  V+  K  Q +  EE +     + EL    +  L ++ +  K L   + +  E
Sbjct: 5451 ----KTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5506

Query: 1841 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG--DLRYIT 1898
                   + E+ L +  Q   +LE   + +  ++  +++ K  +   I+      LR   
Sbjct: 5507 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5566

Query: 1899 ISGNRVLEAAKSCSKRDGGKVD-------TSATHREVQR--KLDHATDRFRSLYSKCNVL 1949
            I    +LE +K          +          T +  Q+  +L   T+  R +     + 
Sbjct: 5567 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIK---IR 5623

Query: 1950 GNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ--LEETKALQ 2007
              NL+D     + +E     L A L+  +AT +      +++  +   RQ  L E ++L+
Sbjct: 5624 LQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLK 5683

Query: 2008 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2067
             ++ + Q+    L+   +V+  A   L  A   +Q          E+ S+  +   ++  
Sbjct: 5684 PKVQAVQLCQSALRIPEDVV--ASLPLCHAALRLQ----------EEASRLQHTAIQQCN 5731

Query: 2068 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDI---ISKNIMLEQDIAGR 2124
            I     +  +    EM      +E + +E    P+ ++ +Q++   IS++  L Q I G 
Sbjct: 5732 IMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGY 5791

Query: 2125 QSSINAMNEKVKKFMETTDPST-------ASSLQAKMKDLSARFSEASHKHKE----TLA 2173
            Q  I ++N K K        +T          L    +DL          H      T  
Sbjct: 5792 QEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG 5851

Query: 2174 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVT---ELSQYMQESTSEFLEH 2230
            +   L + V   E+  E   + + +     +   V   D +   +++ Y   S       
Sbjct: 5852 RCHTLLSPVTE-ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5910

Query: 2231 KKHLEVLHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLD 2289
               +    S  +E    GL PS  A    K  +L + ++ +++ I EK+  +    E+  
Sbjct: 5911 AAKIHPSTSASQEFYEPGLEPSATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQ 5966

Query: 2290 AFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2349
             +Q  ++S+ + ++    K+    P  G     +  E    + E   L+  EI ++ +S 
Sbjct: 5967 KYQDSLQSISTKMEAIELKLS-ESPEPGRSPESQMAEHQALMDEILMLQD-EINELQSSL 6024

Query: 2350 ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYE 2409
                   S    PA+ +A   +                      LT + + M+ I     
Sbjct: 6025 AEELVSESCEADPAEQLALQST----------------------LTVLAERMSTIRMKAS 6062

Query: 2410 DLGLLLKDKI---AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPA-PTDTEAV 2465
                LL++K+    E   +   LQ+ + E+  +  WL     T       P  P D EA 
Sbjct: 6063 GKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA- 6121

Query: 2466 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENP--DTPEAPRWKQMLTEIDSKWQEL 2523
              Q+   ++   E++Q V  + EL      LL E       EA +    L  +     EL
Sbjct: 6122 --QLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6179

Query: 2524 NQLTIDRQ-------QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN 2576
             +   D+Q       Q+ EES  +LT  Q+   Q  +WL +     +     S+      
Sbjct: 6180 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ--EWLAQARTTWTQQRQSSL------ 6231

Query: 2577 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSR---------PGEDPSLR----GIVKEQ 2623
               QQ + L QE A +K     + + G+ IL +          GE P +     G+  E+
Sbjct: 6232 ---QQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK 6288

Query: 2624 LAAVTQ---KWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL-----DNKLSS 2675
             +A  Q   KW+SL  + S +   + Q +++  Q Q L    +  LS +     D     
Sbjct: 6289 SSAEDQMRMKWESLHQEFSTKQKLL-QNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD 6347

Query: 2676 SLAVSTHPDAMNQQLETAQKM-----KQEIQQEKKQ---IKVAQALCEDL-------SAL 2720
              AV++  D +NQ  E          +Q I  E+K    +       +D+       +AL
Sbjct: 6348 KSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATAL 6407

Query: 2721 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL---- 2776
            + EE      ++++  + K  K++ ++ + +      A   +   + +  D    L    
Sbjct: 6408 LPEETETCLFNQEI--LAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 6465

Query: 2777 -----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
                          KE   +       L VL + + D+K     L   ++++E+ +AE  
Sbjct: 6466 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYI--ILQKLANVFEQPVAEQI 6523

Query: 2826 NLL----------------LKTQGS----EKAALQLQLNTIKTNWDTFNKQVKERENKLK 2865
              +                LK +G     E+ ++Q +L+ ++  +D     +  R + L 
Sbjct: 6524 EAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLN 6582

Query: 2866 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2925
            ++L    +Y+  ++ L   ++  Q  +   +  +  ++ E  I +L    KE  Q     
Sbjct: 6583 QNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE--IQQLLDKHKEYFQGLESH 6640

Query: 2926 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 2985
             +L  T    +    + KE  T  +  L+ +   V ++ H +   LE + + +    E  
Sbjct: 6641 MILTETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 6698

Query: 2986 KESKRQLQCAKEQLDIHDSLGSQAYSNKYL----TMLQTQQKSLQALKHQVDLAKRLAQD 3041
            +E  RQL+  +  +    S+G    +   L    T+ Q  + SL   + ++       + 
Sbjct: 6699 QELSRQLEVVESSIP---SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6755

Query: 3042 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3101
            L++  S     SD+  Q+  + +   + + ++ ++   LET L+    +Q+   ++    
Sbjct: 6756 LLISIS----CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 6811

Query: 3102 AEFDDELD----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEE 3157
                D L+        V ++ E ++        F K+++A  +   +   T   +L  ++
Sbjct: 6812 QSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKK 6871

Query: 3158 TSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT-IKRLEEFY--SKLKEFSILLQKA 3214
               D   ++ +L  +  Q   LL    A +E++    + +L   +  S++  +  L++  
Sbjct: 6872 V--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6929

Query: 3215 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3274
             + +E      +  + I++ L  +K F+ +    +  KQ  V+++ Q ++Q +++   ++
Sbjct: 6930 IQKDEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESK 6985

Query: 3275 GLE-----HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3329
              +       L  +N  W+ L   V ++   L+  L     +++ ++ L +W  +T+E  
Sbjct: 6986 RSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKR 7044

Query: 3330 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3389
              Q+    +   V+  +++ + L+ L+  ++  VE I++ G  +    +      ++  L
Sbjct: 7045 LKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTL 7104

Query: 3390 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3449
              L   W  L +        L+ +           + +N +L      L     +     
Sbjct: 7105 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7164

Query: 3450 KLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQVW---Y 3505
             ++ Q+   + L+DD+    + L +  SI  Q LK       + +  +  + +  W    
Sbjct: 7165 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7224

Query: 3506 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS 3565
             EI E+  S   LLQ                  + +      S +  Q+  T  L K  +
Sbjct: 7225 EEIAEQLQSSKALLQL--------------WQRYKDYSKQCASTVQQQEDRTNELLKAAT 7270

Query: 3566 ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3625
               +  +++    Q+ +  LL GL  +K    D +  + +  E +K +      +    A
Sbjct: 7271 NKDIADDEVATWIQDCND-LLKGLGTVK----DSLFFLHELGEQLKQQ------VDASAA 7319

Query: 3626 KTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSYET----------------QVLKGEE 3668
              ++   L L++ L +  + LC     ++  +L YET                ++L+G++
Sbjct: 7320 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQD 7379

Query: 3669 ASQA------QMRPKELKKEAKNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAED 3719
             S +      Q R +ELK +     ++   LD LNE+   L    P   +E   K +   
Sbjct: 7380 PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL----PLNDKE--IKRMQNL 7433

Query: 3720 NERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3779
            N  + L+S   T++  ++ + +L+ Q F +  +  + ++ +TE+KL    +I        
Sbjct: 7434 NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLL 7491

Query: 3780 AQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQIN 3839
             Q +  + F  E+   + I+  ++  G +++     +++     KL  +   +  + +  
Sbjct: 7492 EQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRA 7551

Query: 3840 SERYLQLERAQSLVNQFWETYEELWPWLTETQSI----ISQLPAPALEYETLRQQQEEHR 3895
             +R   ++       ++ E  E+L  WL E   +    +  +P P  +  TL  + +   
Sbjct: 7552 QQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE 7611

Query: 3896 QLRELIAEHKPHIDKMNKTGPQLLELSPG-------EGFSIQEKYVAADTLYSQIKEDVK 3948
            ++   + +   +I  +      LL    G       E   IQEK+ +A     +++E  K
Sbjct: 7612 KV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM---RLEEQKK 7666

Query: 3949 KRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP-PSISAEVEKIKEQISENKNVSV 4007
            K A  L +         D ++++    +++ + L      + AE  + KE  +   + + 
Sbjct: 7667 KLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTD 7726

Query: 4008 DMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKL 4067
            D+ +L  L +TL        A     D  I    + ++++ +   WE +   +  R  ++
Sbjct: 7727 DLTQLSLLKDTLS-------AYISADDISI----LNERVELLQRQWEELCHQLSLRRQQI 7775

Query: 4068 LDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE 4127
             + +     F   +  L   +   +  +    D  I+  + K +++     +EEI   QE
Sbjct: 7776 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKD----YQEEIAIAQE 7831

Query: 4128 ELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQ 4187
                +  +G  L  A  E     ++  + ++N  W  L      R+ KL+E + A  Q  
Sbjct: 7832 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 7891

Query: 4188 DGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4244
              + ++  W+     +LA   PI  D    E +++++ E ++ + +  +    +  + + 
Sbjct: 7892 KNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL 7949

Query: 4245 AELLLKKV---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4301
             E+LL        +++  ++Q     L   W ++    + R+ K+E       +F     
Sbjct: 7950 CEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYS 8009

Query: 4302 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4361
                WL  +E   +     G      + EL K    Q  V    + +E +NK    L   
Sbjct: 8010 RFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE 8069

Query: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421
            +  + A +L+  +   NQRW N+ ++     ++L   + Q + F    + +  WLT+ + 
Sbjct: 8070 NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 8129

Query: 4422 HLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4480
             L   +        AK +QL    +  +    K E    ++ +G+Q++ +        I+
Sbjct: 8130 QLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIE 8186

Query: 4481 QDINNLKEKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQD 4520
            ++++ L+   + V                   E  L++R+ +LE++  L+ + +H+   D
Sbjct: 8187 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 8246

Query: 4521 FINWLTQAEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQIIEL 4569
             +    Q    L+++    L            +D++  + D     + ++ S   + +  
Sbjct: 8247 SL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPS 8305

Query: 4570 -DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWS 4628
             D+ G   K F  +  V L  +      S  E  +++L   G++LDD+R + +Q      
Sbjct: 8306 EDEEGQDDKDFYLRGAVGLSGD-----HSALESQIRQL---GKALDDSRFQIQQ------ 8351

Query: 4629 KLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688
               E +  S+     EL+ +            +K + K LG   S  D+  R    LKE+
Sbjct: 8352 --TENIIRSKTPTGPELDTS------------YKGYMKLLGECSSSIDSVKRLEHKLKEE 8397

Query: 4689 TSLADDNLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4745
                   + L   +   + + D+W+ +  +++ ++ ++++ L    QF   L ++  WL 
Sbjct: 8398 EESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLG 8457

Query: 4746 RVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS 4803
              E +L + Q +    DI  +   I   K  QK +  R + + ++   + E  +    +S
Sbjct: 8458 DTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 8517

Query: 4804 SWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHG 4863
              ++ ++ +++ RW+ VC+L    +  L+ AL Q + FH + H LL  L   ++  R + 
Sbjct: 8518 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNE 8575

Query: 4864 VLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHWI 4919
            ++P D +     L D HK+ M+   +L E +  +     M   +L           K  +
Sbjct: 8576 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKV 8635

Query: 4920 TIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4953
             +I  R + +L    +H + L   L    ++Q+L
Sbjct: 8636 HVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8669



 Score =  266 bits (681), Expect = 3e-70
 Identities = 776/4275 (18%), Positives = 1638/4275 (38%), Gaps = 517/4275 (12%)

Query: 981  YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQES-----QVFSGSDIT 1035
            +L++E+ +I +S+ + +KT +     + L ++  + E+ ++  + S      V S  D  
Sbjct: 2151 HLLSELKKIHSSDFSLVKTDMESTVDKWL-DVSEKLEENMDRLRVSLSIWDDVLSTRD-- 2207

Query: 1036 QLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDR------LIRQ 1089
            ++E   N C     E + + +   + E +   + SEV+N  LRLE    +      L + 
Sbjct: 2208 EIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKN 2267

Query: 1090 IRTP-----LERDDLH--ESVFRITEQEK--------LKKELERLKDDLGTITNKCEEFF 1134
            + TP     +E D +   E    ITE  K           ++E+  +D+ T   K EE  
Sbjct: 2268 LETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL 2327

Query: 1135 SQAAASSSVPTLRSELNVVLQNMNQVYSMSST-------------------------YID 1169
               A + +   L+   ++  +  +Q  ++SST                          I 
Sbjct: 2328 MNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIK 2387

Query: 1170 KLKTVNLVLKNTQAA--EALVKLYETKLCEEE-----AVIADKNNIENLISTLKQWRSEV 1222
            K + V+ +   TQA+  E+L K +   + E +     A  A K + +      K   +++
Sbjct: 2388 KHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDR-TGDSKVLEAKL 2446

Query: 1223 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDF-DWHKEKADQLVERWQNVHVQIDNR 1281
             + + +  ++ D   K  A++ E    Y           +E+  +  E +Q    Q    
Sbjct: 2447 HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKD 2506

Query: 1282 LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ---QKMLV 1338
             + L+     L  + D +  L+ WI ++E  +R   EN  E+ + +  + N+    +M +
Sbjct: 2507 KQALQDCASELGSFEDQHRKLNLWIHEME--ERFNTENLGESKQHIPEKKNEVHKVEMFL 2564

Query: 1339 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1398
             E+   +  +D+  +  +  S        +      ++ S Q      +    S  + +Q
Sbjct: 2565 GELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQ 2624

Query: 1399 EFMDLRTRYTAL---VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAK---ELQKW 1452
            E   L     ++   V  +   +  A  +L   +  EK L + +   + K +   +L   
Sbjct: 2625 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMA 2684

Query: 1453 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE-------ALQTIQLFLAKHGDK 1505
            +    + L+ + K G      Q++   ++ T KE  ++       A  T++  +++  D 
Sbjct: 2685 IGKGEQALRSSNKEG------QRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDY 2738

Query: 1506 MTDEERNELEKQVKTLQE--SYNLLFSESLKQ-------LQE--SQTSGDVKVEEKIVAE 1554
            +  E +N+LE+ ++++ +   + L     LK+       LQ   S+     +   +++A+
Sbjct: 2739 V--ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAK 2796

Query: 1555 RQQEY-------------KEKLQGICDLLTQTENRLIGHQEA----FMIGDGTVELKKY- 1596
             ++ Y             +E      D++T  + ++   +E      M  D   E   + 
Sbjct: 2797 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2856

Query: 1597 QSKQEELQK--DMQGSAQALAEVVKNTENFLKE---NGEKLSQEDKALIEQKLNEAKIKC 1651
             S +EEL +  DM G + A  + +   +  +        +LS+ +    E K N     C
Sbjct: 2857 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2916

Query: 1652 EQLNLKAE--------------QSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1697
            E ++ + +              Q++  L+ +V+     E E    V QLE++  +   LL
Sbjct: 2917 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2976

Query: 1698 -DWL--------SNVDKDSERAGTKHKQVIEQ-NGTHFQEGDGKSAIGE----------- 1736
              W          N D++      K +++++       +  D KS + E           
Sbjct: 2977 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3036

Query: 1737 EDEVNG-----NLLETDVDGQVGTTQENLNQQYQKVKAQHEK-----IISQHQAVIIATQ 1786
              +V+G     N L           ++ L Q+++K     ++      I+  +   I   
Sbjct: 3037 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3096

Query: 1787 SAQV--LLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDA 1844
             ++V   L+K  ++LS  E  + + NM   K    + L   EK       +Q ++     
Sbjct: 3097 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEK----AKGIQAKVTAAKE 3152

Query: 1845 DYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRV 1904
            D+  F   L Q E  LENL+    D       ++   S +E ++    +  Y   +  R 
Sbjct: 3153 DWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRRE 3212

Query: 1905 LEAAKS------CSKRDGGKVDTSATHR-EVQRKLDHATDRFRSLYSKCNVLGNNLKDLV 1957
             +  +S      C +    ++   A    E Q        R   L S+   L N  K+ V
Sbjct: 3213 QQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKV 3272

Query: 1958 DKYQHYEDASCGLLAGLQACE--ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQV 2015
             +             G++  +   T + H+ +       +       T  L+  +S +Q 
Sbjct: 3273 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3332

Query: 2016 AVEKLK----KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLT 2071
               ++K    +   VL +     +P    IQ+ L  +   +  L  +      +L+  L+
Sbjct: 3333 KEIQMKMIVTRGESVLQNTSPEGIPT---IQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3389

Query: 2072 RSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAM 2131
            +  S QDG+ +   WM ++E++L E  +          ++ K  +L +++    S +  +
Sbjct: 3390 KWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETI 3449

Query: 2132 NEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEK 2191
              K     E          Q +++DL  R+     + KE + K E+L    + ++   + 
Sbjct: 3450 EVKGAGMTE------HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKA 3503

Query: 2192 LQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLL---KEISSHG 2248
             + +L  + + L +  V   D       +++     +   +   +L+S+L   +++   G
Sbjct: 3504 FEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSG 3563

Query: 2249 LP--SDKAL-----------------------VLEKTNNLSKKFKEMEDTIKEKKEAV-- 2281
            +P   D+AL                       V+ K   + +KF+++++ +K  +E V  
Sbjct: 3564 IPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSP 3623

Query: 2282 -TSCQEQLDAFQVLVKSLKSWIKETT-----------KKVPIVQPSFGAEDLG-KSLEDT 2328
             T  Q      ++ +  +K W +E T           +   I+  S     +G ++ + T
Sbjct: 3624 RTRRQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT 3683

Query: 2329 KKLQ-------EKWSLKTPEIQKVNNSGISLCNL----------ISAVTTPAKAIAAVKS 2371
             + Q       E+      EIQ +  S  SL +              V T    +  V  
Sbjct: 3684 SRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMM 3743

Query: 2372 G---------------------GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYED 2410
            G                      A   GE      EE  A +    ++K++ D     ++
Sbjct: 3744 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER----LRKEIHDHMEQLKE 3799

Query: 2411 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAV--KTQ 2468
            L   ++ +   L   L   ++  ++  A+ QW+ +  +        P     E    K Q
Sbjct: 3800 LTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL----HVPEEPKMELYEKKAQ 3855

Query: 2469 VEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTI 2528
            + + KS +  +  +   V+ +++K   LLE   D       K  + ++ S +Q+L  +  
Sbjct: 3856 LSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV----TLKDKIDQLQSDYQDLCSIGK 3911

Query: 2529 DRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQE 2588
            +    LE    +   + +   ++++WL++       +    + P++L T    ++ + Q+
Sbjct: 3912 EHVFSLEAKVKDHEDYNSELQEVEKWLLQ-------MSGRLVAPDLLET--SSLETITQQ 3962

Query: 2589 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQA 2648
             A  K   E++      + +   +  +L G   + L A  ++  ++   L    D    A
Sbjct: 3963 LAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQ--NVHAHLQGTKDSY-SA 4019

Query: 2649 IVKSTQ--YQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQ 2706
            I  + Q  YQSL   L   +S  D        +S    A+   LE + +      +  KQ
Sbjct: 4020 ICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLS----AVQPDLEPSPQPPLSRAEAIKQ 4075

Query: 2707 IKVAQALCEDLSALVKEEYLKAELSR-QLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2765
            +K  +AL E     +       +LS   ++   K  +  EQ  E  +   Q+      + 
Sbjct: 4076 VKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135

Query: 2766 QQMSRDFQAWL-DTKKEEQN-KSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAE 2823
            + +  +   +L D  ++ QN K      +L++ ++++   KDF K L ++      TI E
Sbjct: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASV-NTIIE 4194

Query: 2824 GENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWP 2883
              N L K    E++    ++N +   W    +Q      + +E L++   Y + +  +  
Sbjct: 4195 KVNKLTK---KEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEV 4251

Query: 2884 WIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQK---EMDQHFGMVELLNNTANSLLSVCE 2940
            +++K     +     L  ++ E++   L++L+K    + +    +E L +    ++    
Sbjct: 4252 FLEKFTTEWDN----LARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLN 4307

Query: 2941 I-DKEVVTDENKSLIQK----VDMVTEQLHSKKFCLENMT---QKFKEFQEVSKESKRQL 2992
            + DKE+V ++   L Q+     D++  ++      LE +     +F+E  E ++E +  +
Sbjct: 4308 LDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNI 4367

Query: 2993 QCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL------VVEA 3046
              A +Q    D   +Q     +L +    +     LK  +  A R+  DL      V++ 
Sbjct: 4368 AEALKQSPPPDM--AQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQK 4425

Query: 3047 SDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3106
            + S   S V    + + Q    L++ + EK  FL    Q     Q   R++   F E   
Sbjct: 4426 ALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI--MFREHIC 4483

Query: 3107 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3166
             L     V +  +T +  + ++K +  ++  L A      K       TE+   +++G  
Sbjct: 4484 LLPD--DVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKE-----VTEQEKSEVLG-- 4534

Query: 3167 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGM 3226
              L+ L    + +L +   R +++E  +   + F     +    L++A+     +  +  
Sbjct: 4535 -KLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMN 4593

Query: 3227 ETETINQQLNMFK--VFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVN 3284
            E+  ++ QL  ++  + Q  E E L    Q     GQ ++ S         L   L+ + 
Sbjct: 4594 ESSELHTQLAKYQNILEQSPEYENLLLTLQRT---GQTILPS-LNEVDHSYLSEKLNALP 4649

Query: 3285 ARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKA 3344
             ++  +      +  ++QEA+L    +   +E     + + E           +  V +A
Sbjct: 4650 RQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEA 4709

Query: 3345 QIQEQKLLQRLLDD---RKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLN 3401
             +  Q   + +LD+       V+ + ++ E   +T +P    K+L  ++L    +  L  
Sbjct: 4710 -LSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTL----YHRLKR 4764

Query: 3402 KAETRNRQLEGISVVAQQFHETLEPLNEWLTTI--EKRLVNCEPIGTQASKLEEQIAQHK 3459
            + E R   LE  +   Q+  +  + L   L ++  E+  VN E +  +  KL+   +   
Sbjct: 4765 QTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAE-EKLKMYHSLAG 4823

Query: 3460 ALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3519
            +L+D  I   +       +   L  L+  + +  +QS       W  E++  + +  E +
Sbjct: 4824 SLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQS-------WQGELKLLTSAIGETV 4876

Query: 3520 QQALCNAKI-----FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDI 3574
             +  C +++     F  +    ++WL  V  +LS     D + + + ++  ++++ QE++
Sbjct: 4877 TE--CESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEV 4934

Query: 3575 --LLRKQNVDQALLNGLELLKQTTGDEVLI--IQDKLEAIKARYKDITKLSTDVAKTLEQ 3630
               LR  N     L+  E  K T   E++   ++  L  +     DI +       TL +
Sbjct: 4935 QSSLRIMNA----LSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTE 4990

Query: 3631 ALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALL 3690
                 +R +   +    WL+  + ELL      L  E A +      E         + L
Sbjct: 4991 IYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNL 5049

Query: 3691 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3750
            + L+ + + L  L+    +E LE+ VA    R + +S     +V+ +     +   + +A
Sbjct: 5050 EELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKA 5109

Query: 3751 ADAELSWITETEKKLMSLGDIRLEQD-QTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKI 3809
             +  +  + +TEKKL     ++     +   +L   K     +    + I  L +   ++
Sbjct: 5110 REEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQL 5169

Query: 3810 MTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3869
                ++  K ++ + +  V + +  +  +  ++   LE A      F    ++    + +
Sbjct: 5170 EKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQ 5229

Query: 3870 TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE----LSPGE 3925
             Q  +    A       L    E H      + + +  +  + +    +L+     +PGE
Sbjct: 5230 LQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGE 5289

Query: 3926 GFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP 3985
               + ++  A       ++E VK     + + +        +I+ +   ++   E L  P
Sbjct: 5290 EPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP 5349

Query: 3986 P-SISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4044
               I A++E+++  ++E  N   ++EK+       +++ E+ +        ++S +  + 
Sbjct: 5350 TIEIDAQLEELQILLTEATNHRQNIEKM------AEEQKEKYLGLYTILPSELSLQLAEV 5403

Query: 4045 KLDQMVFIWENIHTLVEEREAKLLDVMELA---EKFWCDHMSLIVTIKDTQDFIRDLEDP 4101
             LD  + I + I   ++E E       EL+   +K   D  +++  +K   D        
Sbjct: 5404 ALD--LKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD-------- 5453

Query: 4102 GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSA 4161
                  V Q +   + + EE+DG   +L  +     + +   G+  KP+ KK I +L   
Sbjct: 5454 -----NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKK-IGKLTEL 5507

Query: 4162 WDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD----IAGGKLA--SMSPIGTDLE 4215
                 +  ++R+ KL +A     +Y + L+ +  W++    +A G +A  S S +     
Sbjct: 5508 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5567

Query: 4216 TVKQQIEELKQFKS--EAYQQQIE-------MERLNHQAELLLKKVTE-----ESDKHTV 4261
              +  +EE K+  S  EA  ++++        E+++ Q   L ++  E     +     +
Sbjct: 5568 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5627

Query: 4262 QDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4321
            QD   ++K      E  +   Q  LE A   L   +     L   L+H + LLSE + + 
Sbjct: 5628 QDAAKDMK----KFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESL- 5682

Query: 4322 GDPKAIEIELAKHHV-LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4380
              PK   ++L +  + +  DV+A      A  +           EEAS LQ+        
Sbjct: 5683 -KPKVQAVQLCQSALRIPEDVVASLPLCHAALR---------LQEEASRLQHTAIQQCNI 5732

Query: 4381 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQ 4439
             Q  + + EQ +Q++    +  +G H EIED               KP+     +  + Q
Sbjct: 5733 MQAAVVQYEQYEQEMKHLQQLIEGAHREIED---------------KPVATSNIQELQAQ 5777

Query: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499
            ++ H E+    +  +E   SL  K + +  +   +       ++  L E  E ++ +L  
Sbjct: 5778 ISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLP 5837

Query: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS------RPSLILDTVLFQIDEHK 4553
              +     + +     ++L   +   +  E T +  S       PS + +T    +++  
Sbjct: 5838 TPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDA-SVNQDI 5896

Query: 4554 VFANEVNSHREQ--IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR 4611
             +   +++ R Q    ++  + +  + F +          L  +Q  WE +   + E+ R
Sbjct: 5897 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 5956

Query: 4612 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKE-FQKSLGA 4670
            +L +A +R +++ ++   +   +E  E  L    E    P+   +Q+A+H+    + L  
Sbjct: 5957 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 6013

Query: 4671 KHSVYDTTNRTGRSLKEKTSLAD--DNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL- 4727
            +  + +  +     L  ++  AD  + L L   L+ L ++  TI  K+  ++  LEE L 
Sbjct: 6014 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6073

Query: 4728 --LFSGQFTDALQ-------ALIDWLYRVEPQL-AEDQPVHGDIDLVMNLIDNHKAFQKE 4777
              L   +   ALQ        L  WL   +  L     P    +D+   L+D      + 
Sbjct: 6074 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEI 6133

Query: 4778 LGKRTSSVQALKRSARELIEG---SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAA 4834
              K  +  +    +   L+EG   ++D++  +  +++ L      +      KQ  ++  
Sbjct: 6134 EQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGT 6193

Query: 4835 LRQAEEFHSVVHA-----LLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEK 4889
             ++ EE    + A     + EWLA+A  T              ++ + Q KE  ++L E+
Sbjct: 6194 AQEKEESDVDLTATQSPGVQEWLAQARTTW---------TQQRQSSLQQQKELEQELAEQ 6244

Query: 4890 RAELNKATTMGDTVL 4904
            ++ L    + G+ +L
Sbjct: 6245 KSLLRSVASRGEEIL 6259



 Score =  227 bits (579), Expect = 2e-58
 Identities = 847/4800 (17%), Positives = 1742/4800 (36%), Gaps = 846/4800 (17%)

Query: 591  SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 646
            S  L++N+    +++    D+L+  DE++       W ++ +P +    S+L+NH     
Sbjct: 2182 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2235

Query: 647  AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 692
             ++EFES +K          +K+++++     +  P  L + E     + ++AK +    
Sbjct: 2236 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2292

Query: 693  NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 747
              E    TL +F +++T    ++N+      + EE   + ++  T  A KK    ++ +E
Sbjct: 2293 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2348

Query: 748  LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 798
            L  ++ NI S QE    L  + H A L          I+ + A  Q        L + +E
Sbjct: 2349 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2408

Query: 799  QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 857
            +H  E+   F E+F  AK A             K S DR+     LE  + +     + +
Sbjct: 2409 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2456

Query: 858  LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 917
               +S +  +  + +T+                       +   +I     ++   AN  
Sbjct: 2457 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2495

Query: 918  HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 976
             +A  K              C       ++        E Q++  L LW HE        
Sbjct: 2496 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2535

Query: 977  VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1030
                      +R    N+   K  +P +  +V      L  L +  E   + SQ  Q+ S
Sbjct: 2536 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2585

Query: 1031 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1083
              +     +E  +C Q    +Q LL+  + + +   V    +      ++++   ++  +
Sbjct: 2586 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2644

Query: 1084 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1142
            DRL     T   +D L + + +I +   +K E E +L   +G           + A  SS
Sbjct: 2645 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2695

Query: 1143 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1197
                +  +   L+ + +V++ + S+ +    T+  V+       +    L +  E+   +
Sbjct: 2696 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2755

Query: 1198 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1253
             E  +  +  ++     L   +S + E      AL   + K++ +     DE FK   + 
Sbjct: 2756 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2814

Query: 1254 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1313
                       ++L  ++ ++      ++R +E I K    Y D  H   DW+   +   
Sbjct: 2815 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2863

Query: 1314 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1371
             +  +   ++S T   +L++ K L+   E+  S++   +  A +   + T    EL    
Sbjct: 2864 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2922

Query: 1372 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1417
             +A+        DS  ++      + S   L  QEF            +++AL+    Q 
Sbjct: 2923 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2982

Query: 1418 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
            +                       D+L++ E   + L+ +  E    +++L  +   +S 
Sbjct: 2983 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3042

Query: 1459 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1512
             +K+      +A K   +K++I  +          + L   ++  AK  D  +   E   
Sbjct: 3043 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3102

Query: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
             L+K  + L ES N        +L    + G++              KEK +GI   +T 
Sbjct: 3103 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3149

Query: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1632
             +             +  +E  K Q       KD + SA+ + + +  TE  + E+  +L
Sbjct: 3150 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3203

Query: 1633 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1687
                  + ++  ++  L E      QLN   E++            ++  E  AA K   
Sbjct: 3204 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3251

Query: 1688 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1747
               +++ +    LSN+ K  E+     + V E N   F  G  +      D ++      
Sbjct: 3252 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3301

Query: 1748 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1804
             +D     T +      + +K +    + Q + +   +I T+   VL     Q  SPE  
Sbjct: 3302 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3356

Query: 1805 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1864
              +Q+ ++ +K  + + L+   +          +   +     +F  W+   E  L   E
Sbjct: 3357 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3416

Query: 1865 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1924
                ++    T L + K  +E+V+S+   L  I + G  + E                  
Sbjct: 3417 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3458

Query: 1925 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1984
            H   Q +L    +R+R++  +        + LV  +Q Y+         L+A E    + 
Sbjct: 3459 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3511

Query: 1985 LSE-----PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKN 2039
              +      +  D    +  L + + LQ   +  Q  +  +  T E   D   S +P   
Sbjct: 3512 QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRE---DVIPSGIPQAE 3568

Query: 2040 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099
            D  + L+ +   ++     ++E   +    + +   ++    ++ +W+   E  +  + +
Sbjct: 3569 D--RALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTR 3626

Query: 2100 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2159
               N    +  + +     +++   +  +  +  + ++ ++ +  ++    QA    L++
Sbjct: 3627 RQSNRATKEIQLHQMKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQA--TQLTS 3684

Query: 2160 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2219
            R+        + L +++ L+ +++  E     L ++ +               + ++   
Sbjct: 3685 RYQALL---LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTV 3741

Query: 2220 MQESTSEFLE-HKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSK-------KFKEME 2271
            M     + LE   K +E  HSLLK     G  + K L   +   L K       + KE+ 
Sbjct: 3742 MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3801

Query: 2272 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQPSFGAEDLGKSLEDTKK 2330
             T++++   +         F    K+L  WI E  + + +  +P     +    L   K 
Sbjct: 3802 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKS 3861

Query: 2331 LQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWA 2390
            LQ+      P ++ V   G +L  L+  VT                              
Sbjct: 3862 LQQTVLSHEPSVKSVREKGEALLELVQDVT------------------------------ 3891

Query: 2391 NKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA 2450
                  +K  +  +   Y+DL  + K+ +  L  K+   +    E   + +WL +M+   
Sbjct: 3892 ------LKDKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRL 3945

Query: 2451 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2510
                  P   +T +++T  +Q                                      K
Sbjct: 3946 V----APDLLETSSLETITQQ----------------------------------LAHHK 3967

Query: 2511 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSI 2570
             M+ EI      LN L +     + + +++L      +A+LKQ      +   + G    
Sbjct: 3968 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHL------QAKLKQ-----NVHAHLQGTKDS 4016

Query: 2571 DPNMLNTQRQQVQIL---LQEFATRKPQYEQLTA---AGQGILSRPGEDPSLRGIVKEQL 2624
               + +T ++  Q L   LQ+  +R+   +Q  A   A Q  L    + P  R    +Q+
Sbjct: 4017 YSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQV 4076

Query: 2625 ---AAVTQKWDSLTGQLSDRCDWIDQAIVKST--QYQSLLRSLSDKLSDLDNKLSSSLAV 2679
                A+ ++  +    L   CD +  A VK+T    Q   +++  KL    N       +
Sbjct: 4077 KHFRALQEQARTYLDLLCSMCD-LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4135

Query: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIK--VAQALCEDLSALVKE-EYLKAELSRQLEG 2736
                  +   L+ A +  Q +++   +++  +AQ +   +   VK+ +  +A ++  +E 
Sbjct: 4136 KHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4195

Query: 2737 ILKSFKDVEQKAENHVQHL-----------QSACASSHQFQQMSRDFQAWLDTKK---EE 2782
            + K  K  E      + HL            + C    +  Q +RD+   ++  +   E+
Sbjct: 4196 VNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEK 4255

Query: 2783 QNKSHPISAKLDVLESLI--KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840
                    A+ D   + +  +  K  +  L  + +  E    + + ++      +K  ++
Sbjct: 4256 FTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVK 4315

Query: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNL-EEIKFCL 2899
             Q + ++  W      +K +      +LE+    + + + L  W ++ Q N+ E +K   
Sbjct: 4316 EQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSP 4375

Query: 2900 DPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQK-VD 2958
             P   +N +    ++  E++    +++ L   A+ +++   +++  V  +  S  Q  V+
Sbjct: 4376 PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVN 4435

Query: 2959 MVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS-NKYLTM 3017
             +++ +  ++  L     +  +F     ++  Q+Q  + ++   + +       +K +  
Sbjct: 4436 CLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKT 4495

Query: 3018 LQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3077
             ++ Q SL+  +++V       ++L+ E ++ +  S+VL +++ +   + ++ Q+   + 
Sbjct: 4496 CKSAQASLKTYQNEVTGLWAQGRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRL 4554

Query: 3078 SFLETKLQGIGHFQ------------------------NTIREMFSQFAEFDDELDSMAP 3113
              LE  L    HF+                        N   E+ +Q A++ + L+    
Sbjct: 4555 QELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPE 4614

Query: 3114 VGRDAETLQKQKETIKAFL---------KKLEAL--------MASNDNANKTCKMMLATE 3156
                  TLQ+  +TI   L         +KL AL          + D   K  + +LA +
Sbjct: 4615 YENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARK 4674

Query: 3157 E-------TSPDLVGIKRDL-------------EALSKQ--CNKLLDRA----------- 3183
            E       T+  L  ++                EALS Q  C  +LD             
Sbjct: 4675 EYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4734

Query: 3184 QARE-------------------------EQVEGTIKRLEEFYSKLKEFSILLQKAEEH- 3217
            Q +E                          Q E  +  LE+  S  +E   + Q+ E   
Sbjct: 4735 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQL 4794

Query: 3218 ---EESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL---IQSAAKST 3271
               +E Q  V  ET    ++L M+          L G  QD   + + +   ++  A   
Sbjct: 4795 KSVKEEQSKVNEETLPAEEKLKMY--------HSLAGSLQDSGIVLKRVTIHLEDLAPHL 4846

Query: 3272 STQGLE---HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328
                 E   H +       K L   + +   + +  ++    FQ  +   L W+   +  
Sbjct: 4847 DPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAE 4906

Query: 3329 VANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIK-REGEKIATTAE--PADKVKI 3385
            ++         + ++ +I++ ++ Q  +      +  +  +E EK     E   AD    
Sbjct: 4907 LSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHS 4966

Query: 3386 LKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3445
            L +LS LD   +  L    TR   L  I    Q++++  +  N+WL   ++ L+     G
Sbjct: 4967 LAELSELDGDIQEAL---RTRQATLTEIYSQCQRYYQVFQAANDWLEDAQE-LLQLAGNG 5022

Query: 3446 TQASKLEEQIAQHK---ALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQ 3502
                  EE +  H    + ED   ++ + LH  V+    L   + +ED +   + L+   
Sbjct: 5023 LDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRS 5082

Query: 3503 VWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLS-VQDYSTEGLW 3561
                 +   S ++ +LLQ+       + +   E++  +N+   KLS+ S ++  S+    
Sbjct: 5083 Q---RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAE 5139

Query: 3562 KQQSELRVL-------QEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARY 3614
            ++ SE + L        E I+  ++   Q    G +  K T    +  +  +   ++A  
Sbjct: 5140 EKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVA 5199

Query: 3615 KDITKLSTD-----------VAKTLEQALQLARRL------HSTHEELCTWLDKVEVELL 3657
            +D  K+  D           V K  E   QL  +L       ++  EL T L+  +  +L
Sbjct: 5200 QDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5259

Query: 3658 SYETQ--------------------VLKGEE-----------------ASQAQMRPKELK 3680
              E Q                       GEE                   + +   K +K
Sbjct: 5260 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVK 5319

Query: 3681 KEAKNNKALLDSLN------------------EVSSALLEL-----VPWRAREGLEKMVA 3717
            +E K+ + +   +N                  E+ + L EL          R+ +EKM  
Sbjct: 5320 QELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE 5379

Query: 3718 EDNERYR-----LVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772
            E  E+Y      L S+   Q  E      +R Q  D+  + E S  T  E   +S    +
Sbjct: 5380 EQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQE---LSRQIQK 5436

Query: 3773 LEQDQTSAQLQVQKTFTMEILR----HKDIIDDLVKSGHKIMTACSEEEK---------Q 3819
            L +D T+  L   K  T  +++     K + ++L     K+M   +  +K         +
Sbjct: 5437 LAKDLTTI-LTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5495

Query: 3820 SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPA 3879
             + KK+ K+ + +    +    R  +L +A S + ++ E  E +  W+ E   +++    
Sbjct: 5496 PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI-EKAKVLAHGTI 5554

Query: 3880 PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTL 3939
                   LR+Q   H+ L E   E    ++ M +    L  +   E  S Q   +  +T 
Sbjct: 5555 AWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRET- 5613

Query: 3940 YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEK--IKE 3997
              ++++ +K R   L +A     +F  ++ ++  +LE+    L  P     EV +  +KE
Sbjct: 5614 -EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSP-----EVGRLSLKE 5667

Query: 3998 QISENKNVSVDMEKLQP------LYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
            Q+S  +++  +ME L+P      L ++  +  E+++A         +A  +Q++  ++  
Sbjct: 5668 QLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVA---SLPLCHAALRLQEEASRLQ- 5723

Query: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQ 4111
                 HT +++       V++  E++  +   L   I+      R++ED  +  S +++ 
Sbjct: 5724 -----HTAIQQCNIMQAAVVQY-EQYEQEMKHLQQLIEGAH---REIEDKPVATSNIQEL 5774

Query: 4112 Q---EAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4168
            Q      E + ++I G QE++  + +    L          +    ++ L    + L+  
Sbjct: 5775 QAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLD-- 5832

Query: 4169 WKDRIDKLEEAMQAAVQYQDG-LQAVFDWVDIAGGK------------LASMSPIGTDLE 4215
                +     A  + V    G    +   V    G+              S SP+     
Sbjct: 5833 --GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDA 5890

Query: 4216 TVKQQIEELKQFKSEAYQQQIEMERLN------HQAELLLKKVTEESDKHTVQDPLMELK 4269
            +V Q I         AY Q +  ERL       H +    ++  E   + +    L +L+
Sbjct: 5891 SVNQDI---------AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQ 5941

Query: 4270 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4329
              W++L+  I  +Q  L  AL    ++Q +L  +   +   E  LSE    G  P   E 
Sbjct: 5942 RSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP---ES 5998

Query: 4330 ELAKHHVLQNDVLAHQSTV-EAVNKAGNDLIESSAGEEASN---LQNKLEVLNQRWQNVL 4385
            ++A+H  L +++L  Q  + E  +    +L+  S   + +    LQ+ L VL +R   + 
Sbjct: 5999 QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIR 6058

Query: 4386 EKTEQRKQQLDGAL-------RQAKG---FHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
             K   ++Q L+  L       RQ +    +  E ++L  WL  T+  L  +      P  
Sbjct: 6059 MKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMD 6118

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ---DINNLKEKWES 4492
             + QL     +    E K      L    + +L       +   +Q    +  LK     
Sbjct: 6119 MEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLE 6178

Query: 4493 VETKLNERKTKLEEALNLAMEFHNSLQDFI--------NWLTQAEQTLNVASRPSLILDT 4544
            ++  L++++  ++     A E   S  D           WL QA  T     + SL    
Sbjct: 6179 LQRALHDKQLNMQ---GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQK 6235

Query: 4545 VLFQ-IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIK--------NLLISV 4595
             L Q + E K     V S  E+I+             +K DV+  +        +    +
Sbjct: 6236 ELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQM 6295

Query: 4596 QSRWEKVVQRLVERGRSLDDARKRAKQ--FHEAWSKLMEWL--------EESEKSLDSEL 4645
            + +WE + Q    + + L +  ++ ++   +   ++L+  +         + + ++ S L
Sbjct: 6296 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6355

Query: 4646 EIANDP-DKIKTQLAQHKEFQKSLGAKHSVYDTTNRT----------------------- 4681
            +  N   +++ +Q    K  ++S+  +  +YD  + T                       
Sbjct: 6356 DGLNQAFEEVSSQSGGAK--RQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETE 6413

Query: 4682 ---------GRSLKEKTSLADDNLKL--------DDMLSELRDKWDTICGK-----SVER 4719
                      + +KE +   D N  L         D    + D    + G+     SV  
Sbjct: 6414 TCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVN 6473

Query: 4720 Q------NKLEEALLFSGQFTDALQALIDWLYRVEPQLAE--DQPVHGDIDLVMNLIDNH 4771
            Q       +L++ L F         +L D  Y +  +LA   +QPV   I+ +    D  
Sbjct: 6474 QRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 6533

Query: 4772 KAFQK---ELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQ 4828
            K F     EL +R   +Q  + S +EL                +L   ++ +  +  S++
Sbjct: 6534 KEFDAGIIELKRRGDKLQVEQPSMQEL---------------SKLQDMYDELMMIIGSRR 6578

Query: 4829 TRLEAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHKEFMKKLE 4887
            + L   L    ++   +  L + L   ++ +     ++   ++ ++ L+D+HKE+ + LE
Sbjct: 6579 SGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE 6638



 Score =  213 bits (543), Expect = 3e-54
 Identities = 145/433 (33%), Positives = 223/433 (51%), Gaps = 65/433 (15%)

Query: 24  DVLERYKDERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTL 81
           +V++R +DE++ VQK+TFTKWIN HL K +    V+DL+ED++DG  L++LLEVLSG  L
Sbjct: 16  NVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKL 75

Query: 82  PREKGRM--RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQI 139
           P E+GR   R H + N+  AL +L+ R++KLVNI + DI DG P + LGL+WTIIL+FQI
Sbjct: 76  PCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQI 135

Query: 140 SDIH-------------------VTGESEDM------------SAKERLLLWTQQATEGY 168
            ++                    V+ E+               +AK+ LL W Q      
Sbjct: 136 EELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQ 195

Query: 169 AGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRL 227
            GI  ++F   WR G  F+++IH  RP+L+D+ TV  +SN  NLE AF +AE ++G+ RL
Sbjct: 196 TGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRL 255

Query: 228 LDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYLIQW 286
           LDPEDVDV  PDEKS++TYV+     +P +     +G   +++   +  + N V    + 
Sbjct: 256 LDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKRE 315

Query: 287 IRHHVTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEI 340
            R     M       ER      +    L ++Y  FK   +      + K K++  L++ 
Sbjct: 316 DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHLIQP 371

Query: 341 WIEFGRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPEVER 382
               G++ L Q       ++      +W            G +   +   E ALR E+  
Sbjct: 372 LHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITV 431

Query: 383 LEMLQQIANRVQR 395
            ++ ++ AN +QR
Sbjct: 432 QQVHEETANTIQR 444



 Score =  162 bits (411), Expect = 7e-39
 Identities = 417/2186 (19%), Positives = 829/2186 (37%), Gaps = 298/2186 (13%)

Query: 1009 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1066
            L+  Q +    L+D +   +  S SD+     ++  C      ++ K   R E     + 
Sbjct: 6739 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6798

Query: 1067 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1126
             Y SE  ++   L++ +DRL                 F   +   + +ELE ++D L   
Sbjct: 6799 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6842

Query: 1127 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1171
                +E  +Q++  SSV                TLRSEL+ +      + +      +KL
Sbjct: 6843 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6902

Query: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1222
                L +    +  A+ ++       E  +  D++NI+N I            K ++ ++
Sbjct: 6903 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6960

Query: 1223 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1282
            + K+     +    Q    IS +  ++ +    DF    E+   + + WQ +   +  ++
Sbjct: 6961 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 7014

Query: 1283 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1342
            + LEG+ +S   Y +    L  W +  E  +R  Q+++  +  ++   L   + L   I+
Sbjct: 7015 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7072

Query: 1343 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1402
             K+ ++++ ++         K+ ++ ++    + +  Q +      M     ++++  +D
Sbjct: 7073 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7130

Query: 1403 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1462
              + +      +  Y+  A  SL R      SLE            +Q  V N+     D
Sbjct: 7131 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7179

Query: 1463 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1522
             EK  +   S QK  S      KE      +T                   L   +K + 
Sbjct: 7180 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7217

Query: 1523 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1582
              +N L  E  +QLQ S          K + +  Q YK+  +     + Q E+R      
Sbjct: 7218 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7261

Query: 1583 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1636
                   T EL K  + ++    ++    Q   ++      VK++  FL E GE+L Q+ 
Sbjct: 7262 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7314

Query: 1637 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1696
             A     +   ++   Q     EQ+            K++T   A V   E     +E L
Sbjct: 7315 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7364

Query: 1697 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1756
              W+   ++  +     H                                      + T 
Sbjct: 7365 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7389

Query: 1757 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1816
            QE +    +++K Q  K  S    +          L + G  L   +KE   K M+ L  
Sbjct: 7390 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7435

Query: 1817 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1876
            H+    +++ ++     S   + + F      +  +L Q+EQ+L    +G  +   L+ +
Sbjct: 7436 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7493

Query: 1877 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1936
             +  + F  ++ S +  L  I I G R+LE          G+VD      E   KL   +
Sbjct: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7541

Query: 1937 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 1995
            ++++ +  +       +   + ++Q Y + +  L   L          L S PI +    
Sbjct: 7542 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7601

Query: 1996 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2052
                + Q +E   L+ Q  S  + VE  K   ++LL A      A+  +Q  L +I  ++
Sbjct: 7602 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7654

Query: 2053 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2112
            +  S  + E+ +KL   L      + G+ + L+ +   +  L +   +P +   L     
Sbjct: 7655 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7712

Query: 2113 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2172
            +   LE  +      +  ++               S L  +++ L  ++ E  H   +  
Sbjct: 7713 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7769

Query: 2173 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2227
             + +++  ++  +   SEK +   E  TQ  ++V   G  + E     L +  QE  +  
Sbjct: 7770 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7829

Query: 2228 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2286
             E+K  L+ +   L + S     S+    L K N+  +   ++    +K+ KE + + Q 
Sbjct: 7830 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7888

Query: 2287 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2344
            QLD     + SL++W+     ++  PIV  S  +E++ + L + ++LQ        +I+K
Sbjct: 7889 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7938

Query: 2345 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2404
             +    S+ NL   +     A A               T+ E         SI++   ++
Sbjct: 7939 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7976

Query: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2464
               + ++  +  ++  ++       QK  ++ S    WL+   +TA  +  +     T A
Sbjct: 7977 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 8035

Query: 2465 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2524
             K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQM+ E + +W  L 
Sbjct: 8036 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8093

Query: 2525 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2584
            +      ++L+       +F+T    +  WL E +L ++ +   S     +  + +Q++ 
Sbjct: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--ECDVQAKIKQLKA 8151

Query: 2585 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2644
              QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +    + G++      
Sbjct: 8152 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8209

Query: 2645 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2700
            + +  +   ++    R L    S  LSDL     S+ ++ +   + N  L  AQ ++ E 
Sbjct: 8210 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8269

Query: 2701 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHL 2755
                    V     E     DLS  ++    +A  S   EG  +  KD   +    +   
Sbjct: 8270 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSGD 8327

Query: 2756 QSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSH 2815
             SA  S  Q +Q+ +   A  D++ + Q   + I +K      L   +K + K L   S 
Sbjct: 8328 HSALES--QIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSS 8382

Query: 2816 MYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----NWDTFNKQVKERENKLKESLEK 2870
              + ++   E+ L + + S    + L     +T      W+    Q   +E ++K++L+K
Sbjct: 8383 SID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQK 8441

Query: 2871 ALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2927
              ++   + ++W W+   +  LE+   ++   D    E  I KLK LQK +D    ++  
Sbjct: 8442 WQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILS 8501

Query: 2928 LNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE 2987
            +N  +         +   + D    +  + D V   L   +  L++   + + F E+S  
Sbjct: 8502 INLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMS-- 8559

Query: 2988 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV---DLAKRLAQDLVV 3044
                L    E +D   +      SN    +LQ   K L  +KH++    L     QD+  
Sbjct: 8560 --HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSC 8617

Query: 3045 E-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3101
            +   +++GT   +   +V  I      L ++V      LE KL  +   Q  +    S  
Sbjct: 8618 QLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQDLSSWSSA- 8675

Query: 3102 AEFDDELDSMAPV----GRDAETLQK 3123
                DELD+   V    GR     QK
Sbjct: 8676 ----DELDTSGSVSPTSGRSTPNRQK 8697



 Score = 54.7 bits (130), Expect = 3e-06
 Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)

Query: 4600 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4648
            E ++Q L   G+ SLD A  + + +    S+L +W  + +KSL + L          E+A
Sbjct: 366  EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 424

Query: 4649 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4692
                           + I+ +L QHK+  ++  A     H +Y T +  G  +       
Sbjct: 425  LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 478

Query: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
                   D L ++ +++  +   S        E  L   +F +    L+  L   E +L 
Sbjct: 479  ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 524

Query: 4753 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4807
                 +G  + V  L+ N+ +F    K   +   + Q LK++A   +  +GS +++  V 
Sbjct: 525  SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 584

Query: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
              M E + +W  +     S ++ LE  +   + + + V +L  WL +AE+      +L  
Sbjct: 585  KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 638

Query: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
             E+A        K+F + L     +       G+ ++  C       +K  + ++  R+ 
Sbjct: 639  SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 691

Query: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
            E+    KQ+ Q  A  +  +  K+E  + ++    +A T    K  E +      VK LI
Sbjct: 692  ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 746

Query: 4988 AEHQTFMEEMTRKQPDVDK----VTKT 5010
             +    +E++ ++ P +D     +TKT
Sbjct: 747  QD----LEDIEQRVPVMDAQYKIITKT 769



 Score = 33.5 bits (75), Expect = 6.0
 Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)

Query: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
            D  L LD  L  ++  WD +  +  +   +L+++L         L  +  WLYR E  L 
Sbjct: 375  DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 426

Query: 4753 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4811
            E+  V    +   N I       K+L + T    A KR+  E+      +   V   Q++
Sbjct: 427  EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 483

Query: 4812 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4871
            +++ R+  V + S     ++        EF  + + LL  L  AE  L+   +     ++
Sbjct: 484  DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 535

Query: 4872 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4915
            +  L+  +  F                +K+  E   + + +    + V+   +     T 
Sbjct: 536  VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 591

Query: 4916 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4958
              W      +  +R+  EEV++   ++   +AS  A L            AK++    L 
Sbjct: 592  AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 651

Query: 4959 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5009
             W+Q       A   L +   E++ +++++   L+     + FME     Q D +D++ K
Sbjct: 652  HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 711

Query: 5010 TY 5011
             Y
Sbjct: 712  EY 713


>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
          Length = 3677

 Score =  325 bits (832), Expect = 1e-87
 Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)

Query: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2238
            ++ QT LE     L   +   +   E+S  ++    +F  H+ ++            +L 
Sbjct: 334  DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 393

Query: 2239 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297
               K I +  L  D+   V E+ N L+ +++ +     EK+  +   +  +D     +K 
Sbjct: 394  LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 451

Query: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
            L  W+ +T ++   ++     E LG  LED K+  ++  +   ++++      SL +++ 
Sbjct: 452  LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 507

Query: 2358 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2415
             V   +   A AA++    VL            WAN            I    ED  +LL
Sbjct: 508  VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 546

Query: 2416 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2475
            +D        L K Q+  EE      WL +      K   T      E + + +++    
Sbjct: 547  QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 598

Query: 2476 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2531
            +A+L   KQ++ K+  LK  L   L+    T +   W        D+  Q+L + T    
Sbjct: 599  KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 658

Query: 2532 QKLEESSNNLTQFQTVEA------------------------------------------ 2549
            Q +  +  +LTQ   +E                                           
Sbjct: 659  QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 718

Query: 2550 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605
               +L  W+   E ++ S    +       +  +++V  + +E A +  + +  + + Q 
Sbjct: 719  DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 778

Query: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665
            ++ +   +      +K+    +  +W      LS+R +W++        + + L+ L   
Sbjct: 779  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 837

Query: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2724
             +  +N L       + P A+  QL+  +     +   + QI+  +      S  +KE+ 
Sbjct: 838  TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 893

Query: 2725 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2780
                +L A+         + F DV+ + E  +Q +        ++Q+     + W+   +
Sbjct: 894  QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 951

Query: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840
             + +         +++E  + + +    +L  Q           + +  K         Q
Sbjct: 952  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1011

Query: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
             +   I+  W   + Q+ E   KL+E + K  K +  ++TL  W+ +    L+E      
Sbjct: 1012 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1067

Query: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2949
            PA G++ I     L+K++ Q   +V  +     SL SV E  +++  +           E
Sbjct: 1068 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1122

Query: 2950 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3009
             K L  + D + +Q++++K  L+   +K    Q+   E    +  A+E+    D      
Sbjct: 1123 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1176

Query: 3010 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3069
            +  K    LQ   + ++  K +    K     L+ E+ +S       +  E + +E  TL
Sbjct: 1177 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1235

Query: 3070 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3129
            +      C+ L  K + +        E+ S   + +  L+ +    +  E +    E I 
Sbjct: 1236 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1295

Query: 3130 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3186
              L  LE LM  S DN N+    +LA   T   ++   I  +LE  + +  +L + A  R
Sbjct: 1296 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1353

Query: 3187 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3237
            ++ +E +I+  +E    L   +E    + K      A++ + +Q P   E + I   L  
Sbjct: 1354 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1411

Query: 3238 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3297
             ++  +E  +  QGK+     L Q  I  A K          L DV+ +++ L +K A  
Sbjct: 1412 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1459

Query: 3298 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3357
              +LQE+ +     +  L +L              +  S E +VV++Q+     L + L 
Sbjct: 1460 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1505

Query: 3358 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3417
            + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +QLE    ++
Sbjct: 1506 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1565

Query: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3477
            ++  + +  L EWL   +  L     +    S L+ ++A  KA + +I     HL     
Sbjct: 1566 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1625

Query: 3478 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3537
            +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + F ++   + 
Sbjct: 1626 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1684

Query: 3538 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595
             W+ +    L  S+        + L + ++EL  ++  +   +      + N  +  ++ 
Sbjct: 1685 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1744

Query: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655
               ++  +  +  AI  R K  T  ++   K LEQ     ++L          L+ +E E
Sbjct: 1745 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1792

Query: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715
            +   +   LK E+ +      K++ ++  N   + + L    +    +   R RE ++  
Sbjct: 1793 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1842

Query: 3716 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775
                  ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL SL + R E+
Sbjct: 1843 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1902

Query: 3776 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831
               +   +LQ +K     + R  + +  D    +        S+  ++   K       N
Sbjct: 1903 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1962

Query: 3832 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3886
            +  I  +  E  + +     L ++    TY      +   L E + +++     A ++E 
Sbjct: 1963 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2022

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3945
            L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     D  + ++ +
Sbjct: 2023 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2082

Query: 3946 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4002
              K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  K K  + E 
Sbjct: 2083 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2140

Query: 4003 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4062
            ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W+ +   + +
Sbjct: 2141 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2193

Query: 4063 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4122
            R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E  + + EE+
Sbjct: 2194 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2252

Query: 4123 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4178
               Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A  ++  ++E 
Sbjct: 2253 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2310

Query: 4179 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4234
             ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    +++ +     +
Sbjct: 2311 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2367

Query: 4235 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4278
            Q ++E +  + + L K K   +  K  ++D   E K +   L+E                
Sbjct: 2368 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2427

Query: 4279 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4316
                         ++ ++    KLE   +L+    AL  F  A  EL  WL+  + ++  
Sbjct: 2428 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2487

Query: 4317 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4375
            Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA  +  +++E
Sbjct: 2488 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2547

Query: 4376 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
             +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + K      + 
Sbjct: 2548 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2607

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4495
             ++++    ++       +           ++L          +     N+   W S+  
Sbjct: 2608 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2667

Query: 4496 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4549
            +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+    V   +
Sbjct: 2668 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2727

Query: 4550 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4608
             + +    E+ +H +    LD+     L+      D VL++  L ++  +W ++ ++ + 
Sbjct: 2728 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2787

Query: 4609 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4668
                L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q   H+ F++ L
Sbjct: 2788 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2847

Query: 4669 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4709
              K  V  +T  T                    R L  +    +    L     E+  +W
Sbjct: 2848 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2907

Query: 4710 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4767
            + +   S + Q K++E L    +  +A   L   L + E      QPV GD  ID + + 
Sbjct: 2908 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2966

Query: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
            ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+ +       
Sbjct: 2967 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3019

Query: 4828 QTRLEAALRQAEEFH 4842
            Q  +E  +RQ  E H
Sbjct: 3020 QVAVEDRVRQLHEAH 3034



 Score =  316 bits (809), Expect = 5e-85
 Identities = 548/2809 (19%), Positives = 1128/2809 (40%), Gaps = 353/2809 (12%)

Query: 1839 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1898
            L+++     E   WL  +E  L+     ++D+  +  +    + +  D+ +H+G +  I 
Sbjct: 333  LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 392

Query: 1899 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1958
              G++++   K     +           EVQ +++    R+  L        +NL  ++ 
Sbjct: 393  QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 442

Query: 1959 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2018
              Q+ +     L   L   E    K   EP+  D ++L+RQ+++ K LQ  +  +QV V 
Sbjct: 443  DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 500

Query: 2019 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2077
             L     V+ ++ G    A  + Q K L D   R+ ++ +   +R   LQ  L +   + 
Sbjct: 501  SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 557

Query: 2078 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2131
            +       W+   E ++ +     +++T  +D       + K  +L+ D+  ++ S+  +
Sbjct: 558  EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 612

Query: 2132 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2190
                +  + T  + S     +A + + +  +     K +++ A++ +  T  +   +L++
Sbjct: 613  YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQ 670

Query: 2191 KLQTFLETKTQALTEVDVPGKDVTEL-----SQYMQESTSEFLEHKKHLEV----LHSLL 2241
               T +ET T   T   +  K   E       Q  ++ T +  E +K L+V    LHS +
Sbjct: 671  T--TVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-EIRKRLDVDITELHSWI 727

Query: 2242 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2278
               S   L S +  +  K  N S              +KF++++D  +  +         
Sbjct: 728  TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 786

Query: 2279 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2330
                +++    EQL++    F  L+    +W++     +         E +  + E+  K
Sbjct: 787  GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 846

Query: 2331 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2389
            +Q      TP       S + +C + ++ ++     I  +K     L  +G         
Sbjct: 847  IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 893

Query: 2390 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2447
              +G   +  D    ++ ++ +   ++ +  EL T    L   + QE  SA+  W+Q+ +
Sbjct: 894  --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 950

Query: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507
            +T     Q    TD E ++ ++ + ++ ++ L++  + +  L   + E+ ++ P +  + 
Sbjct: 951  ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1008

Query: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567
            +++    EI+ +W++L+   ++  QKLEE  N L + Q     LK+W+ E ++ +    P
Sbjct: 1009 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1068

Query: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2627
               D  +L  Q +Q ++L+ +  T +P    +   GQ I +    +P     ++ +L  +
Sbjct: 1069 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1126

Query: 2628 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2687
              +WD +  Q+  R + +   + K+   Q  L  + + ++  + +          PD + 
Sbjct: 1127 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1186

Query: 2688 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2745
            + +E  ++ K+E QQ++ ++K+   L E +++++ +    A+  L ++LE +  +++ + 
Sbjct: 1187 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1243

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2798
             +     + L+   A  H+          WL+       T +     +  IS  LD LE+
Sbjct: 1244 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1303

Query: 2799 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2842
            L++  +D        ++TLT    M E    E E    + +   + A++ Q         
Sbjct: 1304 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1363

Query: 2843 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2874
                   L+ I+ +    +KQ+              +   K++        SLE+  K+ 
Sbjct: 1364 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1423

Query: 2875 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2927
              KE  + +   ID  Q  L+++  KF L   PA  E  + + K +  E+  H   +E  
Sbjct: 1424 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1483

Query: 2928 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 2975
                      LN+  N   S+ E+  EV  V    + ++QK     +Q  + K   E +T
Sbjct: 1484 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1538

Query: 2976 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3031
                 + E+     E K+QL+ C K    +   +           M  T++ +++ +   
Sbjct: 1539 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1598

Query: 3032 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3087
            +D      K   +++  +    K  ++V   ++T+  +  TL   V++K S L +    +
Sbjct: 1599 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1655

Query: 3088 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3143
                  + N + E       FD  +D +      A+TL  + E  K   K+ + L     
Sbjct: 1656 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1714

Query: 3144 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3196
              N     + +T + + +L+  + D   + +  Q ++L  R  A   +++       +K 
Sbjct: 1715 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1774

Query: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
            LE+F S +++   LL+  E   E Q  V ++ E  N+ +N          E  +G  +++
Sbjct: 1775 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1819

Query: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
               G  L Q        + ++     +  +   L    +QR  +  E      +++   +
Sbjct: 1820 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1879

Query: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3373
             LL  + D E+ +A+   P  E K+        K + R L  +K  +  ++R+ E +   
Sbjct: 1880 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1931

Query: 3374 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3417
              A   EP  ++++ K+   ++S++     LN A+            T +  LE IS V 
Sbjct: 1932 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1989

Query: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3474
              +   +  +++ L  +E+ L   +        L +Q    K ++D +   +  +   H 
Sbjct: 1990 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2049

Query: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3534
              +          R       S+LDF    + ++ +    R     +++   + F  D  
Sbjct: 2050 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2106

Query: 3535 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3594
                WL E    L K  + +      +K    L+ LQ+ I  R+  V      G E+++Q
Sbjct: 2107 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2164

Query: 3595 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3654
            ++  +  I+Q+KL ++  R++++ K  +D  K LE+   +         E   WL++ + 
Sbjct: 2165 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2223

Query: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3712
             + S   +  K ++  +   + K L +E    + +L  LNE    +L   P    E   L
Sbjct: 2224 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2283

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3765
            E  + + N ++  VS  + +K  EI+A I        + +  ++  +  L W++    +L
Sbjct: 2284 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2343

Query: 3766 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825
                     Q        VQ+T      +  D+ + L K  H       +   Q +K+KL
Sbjct: 2344 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2395

Query: 3826 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3871
            + +   +  + ++  E R  Q + A              +LV Q   T E     L    
Sbjct: 2396 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2455

Query: 3872 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3914
            S++ ++PA A              L  + ++ Q+    +   + E+I + K  +  + + 
Sbjct: 2456 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2515

Query: 3915 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3962
             PQL EL           S  E  +I  ++       + +++E ++ R   L+E +  ST
Sbjct: 2516 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2575

Query: 3963 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4019
            Q+    ++ +Q+L      +E  ++ P     V+ I+++I+E K ++ D+ + Q   +  
Sbjct: 2576 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2632

Query: 4020 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4079
                 +++ R    D       + + ++     W +IH  V EREA L +   L ++F  
Sbjct: 2633 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2688

Query: 4080 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4135
            D    +  + + +     L+D      +++  +   E +++  D LQ E+    D+  NL
Sbjct: 2689 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2747

Query: 4136 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4191
                   L +  G  D  ++++ +D +N  W  L K   +    LE +     +    LQ
Sbjct: 2748 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2807

Query: 4192 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4233
             +  W+ +   +L+  +PIG D   V++Q +  + FK E                    +
Sbjct: 2808 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2867

Query: 4234 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4292
            Q +E +E+L  +   L  +   ++    ++    E+   W+ L     + Q K++  L  
Sbjct: 2868 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2927

Query: 4293 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
            L + Q A DEL   L   E +    +PVG     +++  L K   L+ ++   +  V  V
Sbjct: 2928 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2987

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4400
            N     L          NL + LE LN RW+ +    E R +QL  A R
Sbjct: 2988 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3035



 Score =  313 bits (803), Expect = 2e-84
 Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)

Query: 2373 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2432
            G+ L G G  +  EE       T +++ M  ++  +E L +   +K + L+  L  LQ  
Sbjct: 395  GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 446

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2492
             ++   +  WL K  +   K ++ P   D E +K QV+Q+K  + +L+Q   +V  L   
Sbjct: 447  -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 505

Query: 2493 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2552
            +  + E + D   A   +Q L  +  +W  + + T DR   L++      +    +    
Sbjct: 506  VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 564

Query: 2553 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2611
             WL EKE  V+ +      D N + +  Q++ +L  +   +K    +L +  Q +LS   
Sbjct: 565  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 623

Query: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2654
            ++ S+    +  L    + WD+L  +L      I QA+  +                 T+
Sbjct: 624  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 683

Query: 2655 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2696
             Q L++   ++L            +D+++   L V         T  +A+ Q  E A   
Sbjct: 684  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 743

Query: 2697 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2736
            K+            I++EK +         + AQAL E + +  V  + +K + S QL  
Sbjct: 744  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 802

Query: 2737 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2795
                F  +  +  N +++  +  A  +Q QQ+ +     + T  E   K  P + ++   
Sbjct: 803  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 857

Query: 2796 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2855
            ++S +K  KD    L+      E+   + +++ LK +G     L         ++     
Sbjct: 858  IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 915

Query: 2856 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2912
             V+ RE +L+   +    ++Y+E +  +  W+ + +  L   +  +   E  E  + +L+
Sbjct: 916  DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 975

Query: 2913 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 2972
            +LQ  + +    +  L+ T      V E+ K+  ++ ++    + + +  +       L 
Sbjct: 976  ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1029

Query: 2973 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3024
               QK +E     ++ +  +Q  K+   ++D+       +LG      K L   +     
Sbjct: 1030 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1089

Query: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3084
            +Q ++  ++      Q +  EA + +  S +  +++ +  +   + QQV  +   L+  L
Sbjct: 1090 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1148

Query: 3085 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3144
            +     Q  + EM     + ++E        +  + LQK  E +K          A  + 
Sbjct: 1149 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1199

Query: 3145 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3196
              K  K+ L TE  +  +          +K++LE L+     L  R   + + +E     
Sbjct: 1200 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1259

Query: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
              E  S L++ +  L + E   ++   +    E I++ L+  +   +      +     +
Sbjct: 1260 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1315

Query: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
              L Q L          + +  +L+  N+RW+ L+++  +R   L++++      Q A E
Sbjct: 1316 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1366

Query: 3317 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3373
            +  S  +  E L    K  +A    KV  AQ+ QE + +Q  L   + ++E +K+  +  
Sbjct: 1367 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1426

Query: 3374 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3432
                    ++ +  K+L  +  ++      A    R  E   +        L+ +   L 
Sbjct: 1427 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1478

Query: 3433 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3492
             +E + V  E + +Q   L   +  +K+L +        +   +  G+ +      E+  
Sbjct: 1479 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1531

Query: 3493 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3552
             +  ++   ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S 
Sbjct: 1532 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1591

Query: 3553 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
             +     L  + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + +
Sbjct: 1592 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1650

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
             +  +T  + +    L +  +         + +  W+  ++ + L  E++  K ++    
Sbjct: 1651 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1708

Query: 3673 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732
                K LK E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  
Sbjct: 1709 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1763

Query: 3733 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3792
            K  +    +   +QF+              +KL+   +  ++Q     +    K    + 
Sbjct: 1764 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1811

Query: 3793 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3851
              ++  + +L++ G  +    ++E K + +K K   +   ++ +  + S+R  +      
Sbjct: 1812 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1869

Query: 3852 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3911
               Q+    ++L   L + +  ++ LP P            + R+++E+  E +   +++
Sbjct: 1870 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1918

Query: 3912 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3967
            N    Q   LS  G   +++   +     + +I+      ++   A    + + T     
Sbjct: 1919 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1978

Query: 3968 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4027
             D  LE        L +   +S  + ++++ ++     + D E L    E+LK   + + 
Sbjct: 1979 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2038

Query: 4028 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4074
              SG  D   S K              +Q+ L Q+ F WE ++ + ++R+ +    +E  
Sbjct: 2039 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2098

Query: 4075 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4131
             +F  D       + + + F+R  + P        +  E A+    ++E  DG+ +   +
Sbjct: 2099 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2150

Query: 4132 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4188
            V  L   G E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q 
Sbjct: 2151 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2210

Query: 4189 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4248
             L     W++ A   +AS+       + +K+++E++K    E   +Q  +++LN     +
Sbjct: 2211 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2269

Query: 4249 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4303
            L       EE DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L  
Sbjct: 2270 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2327

Query: 4304 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4356
                 L WL+     L    Q    G     E E+A        V A Q  VE +   G 
Sbjct: 2328 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2379

Query: 4357 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4384
             L +     +   ++ KLE L+  W+ V                                
Sbjct: 2380 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2437

Query: 4385 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
                  ++T   K ++  +L         F+    +L  WL+  ++ + + + + G  E 
Sbjct: 2438 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2497

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4494
              E +          E +    + L+   Q +  +   + A T I   I  ++ +W+ V+
Sbjct: 2498 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2557

Query: 4495 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4554
              L  R+ +L E L  + ++  + ++    L QA   L         +D +  +I E K 
Sbjct: 2558 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2617

Query: 4555 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4614
             A ++   +  +   +     L       D   +  +  ++ + W  + +R+ ER  +L+
Sbjct: 2618 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2677

Query: 4615 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4668
            +  +  +QF     K + WL E+E + +       +  +  D   +K  + Q ++ Q  +
Sbjct: 2678 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2737

Query: 4669 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728
             A   VY   +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +  
Sbjct: 2738 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2797

Query: 4729 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4782
               +   +LQ L+ WL   + +L+   P+ GD   V    D H+AF++EL  +       
Sbjct: 2798 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2857

Query: 4783 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
                           ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   
Sbjct: 2858 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2917

Query: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887
            Q +++  L + +E       L   L +AE        + D       LID  ++ ++K++
Sbjct: 2918 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2971

Query: 4888 EKRAEL 4893
              R E+
Sbjct: 2972 ALRGEI 2977



 Score =  308 bits (789), Expect = 1e-82
 Identities = 502/2696 (18%), Positives = 1071/2696 (39%), Gaps = 346/2696 (12%)

Query: 2650 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2709
            V   +YQ+ L  +   L   ++ L +   +S   + +  Q  T +    ++   + ++  
Sbjct: 331  VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 390

Query: 2710 AQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQM 2768
               L   L    K  E  + E+  Q+  +L S  +  + A    Q          Q Q++
Sbjct: 391  ILQLGSKLIGTGKLSEDEETEVQEQMN-LLNSRWECLRVASMEKQSNLHRVLMDLQNQKL 449

Query: 2769 SRDFQAWLDTKKEEQNKS---HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
             ++   WL TK EE+ +     P+   L+ L+  ++ HK   + L  Q  +   ++    
Sbjct: 450  -KELNDWL-TKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLE-QEQVRVNSLTHMV 506

Query: 2826 NLLLKTQGSEK-AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2884
             ++ ++ G    AAL+ QL  +   W    +  ++R   L++ L K  +  E+      W
Sbjct: 507  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 566

Query: 2885 IDKCQNNLEEIKFC--LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2942
            + + ++ + +I      D  E  +S+ KL  L+ ++++    +  L +    LLS   + 
Sbjct: 567  LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST--LK 624

Query: 2943 KEVVTDENKS-----------LIQKVDMVTEQLH----------SKKFCLENMTQKFKEF 2981
             + VT + ++           L+QK++  T Q+           ++   +E +T      
Sbjct: 625  NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 684

Query: 2982 QEVSK-----------ESKRQLQCAKE---QLDIHDSLGSQAYSNKYLTMLQT------- 3020
            Q + K           + KRQ+    E   +LD+ D     ++  +   +LQ+       
Sbjct: 685  QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV-DITELHSWITRSEAVLQSPEFAIFR 743

Query: 3021 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQ--------VETIAQEHSTLSQQ 3072
            ++ +   LK +V+  +R   +   +  D+  ++  L++         ++I Q    L+ +
Sbjct: 744  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 803

Query: 3073 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3132
              E C  L  +L  +  +QN I   ++Q  + +    +     +   T   +   IK+ L
Sbjct: 804  WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 862

Query: 3133 K----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3188
            K    ++  L        +     +A +E     + +  D  A +    ++    QARE+
Sbjct: 863  KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 922

Query: 3189 QVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3246
            +++     L    +   +      +Q++E           + E + Q+L   +  Q    
Sbjct: 923  ELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSS-- 980

Query: 3247 EPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3304
              LQ +Q  + +L   + + + K+ S  ++  + + +++  RWK L+ ++ +   +L+E 
Sbjct: 981  --LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 1038

Query: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3364
            +    + Q+ +++L  WM + +  +  + P   + +++K Q+++ +LL   +   + ++ 
Sbjct: 1039 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLN 1098

Query: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3424
             +   G+KI   AEP    ++  +L  L+++W+ +  +   R   L+G         + L
Sbjct: 1099 SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDL 1158

Query: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3484
              ++EW+T  E+  +  +       +L++ + + K  +++       +        S+  
Sbjct: 1159 SEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1218

Query: 3485 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKIFGEDEVELMNWLNEV 3543
             +    ++ ++ +L+     Y  +  + + + + L++   C  ++    E +   WLNEV
Sbjct: 1219 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE-KANKWLNEV 1277

Query: 3544 HDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL- 3601
              KL        +TE +     E+  VL     L + + D    N + +L QT  D  + 
Sbjct: 1278 EFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--NQIRILAQTLTDGGVM 1328

Query: 3602 --IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH-STH--EELCTWLDK----- 3651
              +I ++LE   +R++++ + +    K LEQ++Q A+    S H  +E  T++DK     
Sbjct: 1329 DELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1388

Query: 3652 ----------------VEVELLSYETQVLK------GEEASQAQM--------------- 3674
                            ++ +L S+E  + +      G+EA+Q  +               
Sbjct: 1389 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM 1448

Query: 3675 ------RPKELKKEAKNNKALLD-------------------------------SLNEVS 3697
                  +P   ++  + +K +LD                               SL+EV 
Sbjct: 1449 KFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 1508

Query: 3698 SALLELVPWRAREGLEKMVAED----NER-------YRLVSDTITQKVEEIDAAILRSQQ 3746
            S + E+V    R+ ++K   E+    +ER       Y  +   +T++ ++++  +  S++
Sbjct: 1509 SEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1567

Query: 3747 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806
              +  +    W+  T+ +L     +        +++   K    EI + K  +  + + G
Sbjct: 1568 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1627

Query: 3807 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866
              + T   ++E   ++ KL  +  N+  +     E    L   Q  +  F +  + +  W
Sbjct: 1628 EALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1686

Query: 3867 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3926
            + +  +++        E E  + QQ+E   L+ L AE      K++ T  Q   L    G
Sbjct: 1687 IIQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRG 1738

Query: 3927 FS----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 3982
                  ++ +    +  ++ I   +K    ++   + +  QF+  I ++LE LE  +++ 
Sbjct: 1739 DHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ- 1795

Query: 3983 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042
                 ++ + E   + ++E+   +V         + L QRG+ +  R     K    K  
Sbjct: 1796 ----GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIK 1842

Query: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4102
            Q  L         +  L  +R  K L++     ++      L+  + D +  +  L +P 
Sbjct: 1843 QQLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1899

Query: 4103 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4162
             D   +K+     +  +EE++ ++ + +    L  +  A   EP +  + K   E+ S +
Sbjct: 1900 -DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKF 1955

Query: 4163 DSLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSP 4209
                +    +I  + EE M    +            Y   +  V   +      L +   
Sbjct: 1956 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2015

Query: 4210 IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4269
               D E + +Q E LK  K    Q    ++ ++ +    L+  T   ++  +Q+ L +L 
Sbjct: 2016 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLD 2074

Query: 4270 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIE 4328
              W+ + +   +RQ + + ++    +F + +     WLT  E  L + Q P   +    +
Sbjct: 2075 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2134

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4388
              L +   LQ+ +   Q+ V  +N  G ++I+ S+  +AS LQ KL  LN RWQ V ++ 
Sbjct: 2135 WYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2191

Query: 4389 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVC 4447
              RK++L+        F  ++ +   WL + +   +AS PL  G  +  KE+L     + 
Sbjct: 2192 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLV 2249

Query: 4448 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKL 4504
                 ++   K L + G  +L   P S E   D+  N LK+   +W  V   L E++ ++
Sbjct: 2250 EELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEI 2308

Query: 4505 EEALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFAN 4557
            E  +    +    L+D        + WL+     L + ++P+       F + E ++   
Sbjct: 2309 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI--- 2362

Query: 4558 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------ 4611
             V + +  + E+   G HL  + +K     +K  L  + S W K V RL++  R      
Sbjct: 2363 AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDL 2419

Query: 4612 ------------------------------------SLDDARKRAKQFHEAWSKLMEWLE 4635
                                                SL         F+ AW++L +WL 
Sbjct: 2420 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS 2479

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4695
              ++ + S+  +  D + I   + + K   + L  +    +      ++LK KTS  +  
Sbjct: 2480 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEAR 2539

Query: 4696 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4755
              + D +  ++++WD +      R+ +L E L  S Q+ +A +     L +   +L   +
Sbjct: 2540 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 2599

Query: 4756 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELS 4814
                 +D +   I   K   K+L +  ++V      A +L+   S DD+  V +  + ++
Sbjct: 2600 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 2659

Query: 4815 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT 4874
              W ++      ++  LE   R  ++F   +   L WL EAE T     VL D     R 
Sbjct: 2660 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERL 2716

Query: 4875 LIDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRA 4924
            L D    KE MK+ ++ + E+   T +   +         ++   D    ++  +  +  
Sbjct: 2717 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2776

Query: 4925 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK 4984
            ++ E+   +   +  L ++          L+ LL WLQ  +  L+ +    I  +   V+
Sbjct: 2777 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQ 2834

Query: 4985 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLY 5044
                 H+ F  E+  K+P +    +T +            I + ++   G ++     LY
Sbjct: 2835 KQNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LY 2877

Query: 5045 PSGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5092
                +   E +   V  L+ K        W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 2878 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2933



 Score =  295 bits (755), Expect = 8e-79
 Identities = 474/2585 (18%), Positives = 1053/2585 (40%), Gaps = 294/2585 (11%)

Query: 2534 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2593
            L ES  NL ++QT   ++  WL+  E  +   G +S D  ++  Q    +  + +    +
Sbjct: 326  LMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQ 385

Query: 2594 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2653
             +   +   G  ++            V+EQ+  +  +W+ L     ++   + + ++   
Sbjct: 386  GRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 445

Query: 2654 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA--MNQQLETAQKMKQEIQQEKKQIK--V 2709
              +  L+ L+D L+  + +          PD   + +Q++  + ++++++QE+ ++    
Sbjct: 446  NQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 503

Query: 2710 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2769
               +  D S+    ++  A L  QL+ +   + ++ +  E+    LQ       +  +  
Sbjct: 504  HMVVVVDESS---GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 560

Query: 2770 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2829
              F AWL  K++  NK H             KD  +   +L                   
Sbjct: 561  CLFSAWLSEKEDAVNKIHTTG---------FKDQNEMLSSL------------------- 592

Query: 2830 KTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID--- 2886
                 + A L+  L           KQ   +   LK+ L   LK K   +    W+D   
Sbjct: 593  ----QKLAVLKADLEK--------KKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 640

Query: 2887 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2946
            +C +NL +    L+ +  + S A + + Q  + Q   M  +   T    + V    +E+ 
Sbjct: 641  RCWDNLVQ---KLEKSTAQISQA-VTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 696

Query: 2947 TDE---------NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE 2997
                        +  + +++D+   +LHS     E + Q   EF    KE        KE
Sbjct: 697  PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS-PEFAIFRKEG--NFSDLKE 753

Query: 2998 QLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3057
            +++  +   ++ +       LQ   +S QAL               VE   ++G     +
Sbjct: 754  KVNAIEREKAEKFRK-----LQDASRSAQAL---------------VEQMVNEG-----V 788

Query: 3058 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3117
              ++I Q    L+ +  E C  L  +L  +  +QN I   ++Q  + +    +     + 
Sbjct: 789  NADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKI 847

Query: 3118 AETLQKQKETIKAFLK----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3173
              T   +   IK+ LK    ++  L        +     +A +E     + +  D  A +
Sbjct: 848  QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 907

Query: 3174 KQCNKLLDRAQAREEQVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3231
                ++    QARE++++     L    +   +      +Q++E           + E +
Sbjct: 908  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 967

Query: 3232 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKT 3289
             Q+L   +  Q      LQ +Q  + +L   + + + K+ S  ++  + + +++  RWK 
Sbjct: 968  EQRLGELQALQSS----LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1023

Query: 3290 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3349
            L+ ++ +   +L+E +    + Q+ +++L  WM + +  +  + P   + +++K Q+++ 
Sbjct: 1024 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1083

Query: 3350 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ 3409
            +LL   +   + ++  +   G+KI   AEP    ++  +L  L+++W+ +  +   R   
Sbjct: 1084 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1143

Query: 3410 LEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN 3469
            L+G         + L  ++EW+T  E+  +  +       +L++ + + K  +++     
Sbjct: 1144 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1203

Query: 3470 KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKI 3528
              +        S+   +    ++ ++ +L+     Y  +  + + + + L++   C  ++
Sbjct: 1204 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1263

Query: 3529 FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLN 3587
                E +   WLNEV  KL        +TE +     E+  VL     L + + D    N
Sbjct: 1264 LSYLE-KANKWLNEVEFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--N 1313

Query: 3588 GLELLKQTTGDEVL---IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA----RRLHS 3640
             + +L QT  D  +   +I ++LE   +R++++ + +    K LEQ++Q A    + LH 
Sbjct: 1314 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1373

Query: 3641 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSAL 3700
              E L T++DK   +L +Y   +    +A+Q     ++++ +  +++  L+ + + +   
Sbjct: 1374 IQESL-TFIDK---QLAAY---IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN--- 1423

Query: 3701 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ---FDQAADAELSW 3757
                  + +E  ++++++         D   +K++++       Q+   F+Q        
Sbjct: 1424 ------QGKEAAQRVLSQ--------IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1469

Query: 3758 ITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEE 3817
            + E +  L +L    +EQ+   +QL         +   K  ++ ++K+G +I+     E 
Sbjct: 1470 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1529

Query: 3818 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3877
             + + +++  +  +Y+ +    +ER  QLE+   L  +  +    L  WL  T   +++ 
Sbjct: 1530 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1589

Query: 3878 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3937
             A       L  +    +  ++ I + K H+  + + G  L  +   +   +++K     
Sbjct: 1590 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL---- 1645

Query: 3938 TLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE 3997
            +L +     V  RA   +E ++   ++   ++   ++++ I + + Q  ++  E EK K 
Sbjct: 1646 SLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1702

Query: 3998 QISEN--KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4055
            Q  E+  K +  ++  ++P  ++ + +   ++A  G    D   K V+ ++ ++   +  
Sbjct: 1703 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELNHRFAA 1758

Query: 4056 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4115
            I   ++  +A +   ++  E+F  D   L+  ++       +L++   +  + +  +   
Sbjct: 1759 ISHRIKTGKASI--PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 1816

Query: 4116 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4175
            + + +  D LQ+ +               E  +  +K     L +  ++L      R  K
Sbjct: 1817 KELLQRGDNLQQRI-------------TDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1863

Query: 4176 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ 4235
              E      QY+     +   +D    KLAS+ P   D   +K+   EL++ K       
Sbjct: 1864 ALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQKKKE------ 1916

Query: 4236 IEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN-------RQHKL-E 4287
             E+  +  QAE L    +E+     V+   ++L   W  +E +          + H + E
Sbjct: 1917 -ELNAVRRQAEGL----SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE 1971

Query: 4288 GALLALG-----QFQHALDELLAWLTHTEGLLSEQKPVGGDP----KAIEIELAKHHVLQ 4338
              ++ +      +  +     L  +TH    L E + +   P    K  E    +   L+
Sbjct: 1972 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 2031

Query: 4339 N--DVLAHQS-TVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4395
            N  D L   S  ++ ++      ++S+   E   LQ  L  L+ +W+ V +  + R+ + 
Sbjct: 2032 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 2091

Query: 4396 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET---AKEQLNVHMEVCAAFEA 4452
            D ++ + + FH +I+   QWLT+ E+ L  ++    +PE    AK +  +  E+      
Sbjct: 2092 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYL-KELQDGIGQ 2146

Query: 4453 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4512
            ++   ++L   G++++ +  K+  + + + + +L  +W+ V  +L++RK +LEE  N+  
Sbjct: 2147 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2206

Query: 4513 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4572
            EF   L +F+ WL +A+   ++   P      +  ++++ K+   E+   +  + +L++T
Sbjct: 2207 EFQRDLNEFVLWLEEADNIASIPLEPGK-EQQLKEKLEQVKLLVEELPLRQGILKQLNET 2265

Query: 4573 G----THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERG-------RSLDDARKRAK 4621
            G           ++QD   ++N L     +W KV + L E+        + L    K+ +
Sbjct: 2266 GGPVLVSAPISPEEQD--KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2323

Query: 4622 QFHEAWSKLMEWLEESEKSLDSELEIANDP------DKIKTQL---AQHKEFQKSLGAKH 4672
               E  + L+ WL      + ++LEI N P      D  +T++   A+  + ++ L    
Sbjct: 2324 DLEEQLNHLLLWL----SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2379

Query: 4673 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD------TICGKS---------- 4716
             +Y     T    ++   L+ +   ++ +L ELR K        T  G S          
Sbjct: 2380 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 2439

Query: 4717 -----------VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4765
                       +E  + L   +     F  A   L DWL  ++  +   + + GD++ + 
Sbjct: 2440 PVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDIN 2499

Query: 4766 NLIDNHKAFQKELGKRTSSVQALKRSARELIE--GSRDDSSWVKVQMQELSTRWETVCAL 4823
             +I   KA  ++L +R   ++ L  +A+ L     +++  + +  +++ +  +W+ V   
Sbjct: 2500 EMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEH 2559

Query: 4824 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4883
              +++ +L   L+ + ++        + L +A   L      P   DA++  I + K+  
Sbjct: 2560 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2619

Query: 4884 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4943
            K L + +  ++ A  +   +L     D    + H IT      E + A  +   +R++  
Sbjct: 2620 KDLRQWQTNVDVANDLALKLLRDYSADDTRKV-HMIT------ENINASWRSIHKRVSER 2672

Query: 4944 LAGLIAKQEL-------LEALLAWLQWAETT---LTDKD-KEVIPQEIEEVKALIAEHQT 4992
             A L     L       LE  LAWL  AETT   L D   KE + ++ + VK L+ + Q 
Sbjct: 2673 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 2732

Query: 4993 FMEEM 4997
               E+
Sbjct: 2733 LQGEI 2737



 Score =  277 bits (708), Expect = 2e-73
 Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)

Query: 2077 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2136
            Q  L+E+L W+ + E +L+ QG++  +   ++D    +     D+   Q  +  + +   
Sbjct: 337  QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 396

Query: 2137 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2194
            K + T   S    + +Q +M  L++R+        E  + +   +  ++L     ++L  
Sbjct: 397  KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 454

Query: 2195 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2248
            +L TKT+  T   E +  G D+ +L + +Q+       HK   + LE     +  ++   
Sbjct: 455  WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 506

Query: 2249 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2301
            +  D++     T  L ++ K + D      +  ++     Q+ L  +Q L +      +W
Sbjct: 507  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 566

Query: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2347
            + E    V  +  + G +D  + L   +KL               + +SLK   +  + N
Sbjct: 567  LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 625

Query: 2348 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397
              ++      L N      + V    K+ A +    AV   + + T T        +T+ 
Sbjct: 626  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 682

Query: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457
             ++   + H  E+L      K  ++       ++   + + +  W+ +         Q+P
Sbjct: 683  -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 737

Query: 2458 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2513
              A    E   + +++   + E E  +   K+Q+       L+E+  +    A   KQ  
Sbjct: 738  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 797

Query: 2514 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2573
             +++S+W E  QL  +R   LE   NN+  F     QL+Q     E  + +      +P 
Sbjct: 798  EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 856

Query: 2574 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2633
             + +Q +  +  +   +  +PQ E+L       L   G+ P     +     A T  +  
Sbjct: 857  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 912

Query: 2634 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2691
            +   +  R   +      +   +YQ  + ++   +   + KLS      T  + M Q+L 
Sbjct: 913  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 972

Query: 2692 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2751
              Q ++  +Q+++  +       +++S     E +  +   + E I   +K +  +   H
Sbjct: 973  ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1031

Query: 2752 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2811
             Q L+       + Q   +  + W+        +  P     ++L+  +K  +     + 
Sbjct: 1032 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1091

Query: 2812 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2871
                        G+ +  + +    + L+ +L  + T WD   +QV  R+  LK  LEK 
Sbjct: 1092 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1151

Query: 2872 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2930
            +  ++ +  +  W+ + +    E  F    P E + ++ ++K  ++E  Q    V+LL  
Sbjct: 1152 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1211

Query: 2931 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 2989
            + NS+++    + +E +  E ++L      +  +L+ K   LE +   + E     +++ 
Sbjct: 1212 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1271

Query: 2990 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3048
            + L   + +L   +++ G     ++ L  L+   +  +   +Q+ +   LAQ L      
Sbjct: 1272 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1323

Query: 3049 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3106
              G  D L+  ++ET       L ++   +   LE  +Q     + ++  +       D 
Sbjct: 1324 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1383

Query: 3107 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3166
            +L +      DA  + ++ + I++ L   E                ++ EE      G +
Sbjct: 1384 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1427

Query: 3167 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3223
                 LS+     +D AQ + + V    +  ++   F  +L+E  ++L + + H  +   
Sbjct: 1428 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1482

Query: 3224 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3283
              +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +
Sbjct: 1483 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1540

Query: 3284 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3343
               +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + 
Sbjct: 1541 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1600

Query: 3344 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3403
            +++   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++A
Sbjct: 1601 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1659

Query: 3404 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3463
            E     L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +
Sbjct: 1660 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1717

Query: 3464 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3515
            DI              Q+  ++++R D  + +V+ ++      F+ + + I+  + S   
Sbjct: 1718 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1772

Query: 3516 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3569
             EL Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+
Sbjct: 1773 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1830

Query: 3570 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
              E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K
Sbjct: 1831 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1890

Query: 3627 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3683
             L    +    R++     EL     K E+  +  + + L  + A+ A +    +L K  
Sbjct: 1891 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1948

Query: 3684 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3742
            +  ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L
Sbjct: 1949 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2004

Query: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3802
              +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +
Sbjct: 2005 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2064

Query: 3803 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3862
                 K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ       
Sbjct: 2065 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2110

Query: 3863 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3922
               WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S
Sbjct: 2111 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2165

Query: 3923 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981
                 SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + 
Sbjct: 2166 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2224

Query: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041
            +   P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     
Sbjct: 2225 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2282

Query: 4042 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4092
            +++KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   +
Sbjct: 2283 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2340

Query: 4093 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4152
            + +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK
Sbjct: 2341 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2392

Query: 4153 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4177
            + +++L+S W ++N+  ++                                    I KLE
Sbjct: 2393 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2452

Query: 4178 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4231
                    + A   +      + DW+ +    + S   +  DLE + + I + K    + 
Sbjct: 2453 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2512

Query: 4232 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4291
             Q++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L 
Sbjct: 2513 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2572

Query: 4292 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
               Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  
Sbjct: 2573 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2632

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
            N     L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E 
Sbjct: 2633 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2692

Query: 4412 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4465
               WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q
Sbjct: 2693 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2752

Query: 4466 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4524
            ++L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + W
Sbjct: 2753 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2812

Query: 4525 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4584
            L   +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q 
Sbjct: 2813 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2869

Query: 4585 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4635
            +  ++ L      +  + R + V + L          RK+A++ +  W KL     +W  
Sbjct: 2870 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2919

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQ 4660
            + +++L+   E+    D++  +L Q
Sbjct: 2920 KIDETLERLQELQEATDELDLKLRQ 2944



 Score =  226 bits (576), Expect = 5e-58
 Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)

Query: 3299 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3358
            + L E+ ++  R+Q ALE +LSW++  E+ +  Q   S + +VVK Q    +     L  
Sbjct: 324  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 383

Query: 3359 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3416
             +  V  I + G K+  T + +  ++ ++ +Q++LL+SRWE L   +  +   L  + + 
Sbjct: 384  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 443

Query: 3417 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3470
             Q  ++ L+ LN+WLT  E+R   +  EP+G     L+ Q+ QHK L++D+    +  N 
Sbjct: 444  LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 501

Query: 3471 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3530
              H  V + +S    S       ++ +L      +  I   +  R  LLQ  L   +   
Sbjct: 502  LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 557

Query: 3531 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3590
            E++     WL+E  D ++K+      T G   Q   L  LQ+  +L+           LE
Sbjct: 558  EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 603

Query: 3591 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3650
              KQ+ G    + QD L  +K +                          S  ++   WLD
Sbjct: 604  KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 637

Query: 3651 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3710
                    ++  V K E+++    +     + +     +++++  V++    LV   A+E
Sbjct: 638  NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 693

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
             L        ++ ++  D+  +K  ++D   L             SWIT +E  L S   
Sbjct: 694  ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 739

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3826
                ++   + L+ +K   +E  + +    + D  +S   ++     E     S+K+  +
Sbjct: 740  AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 798

Query: 3827 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3886
            ++   +   CQ+ SER   LE   +++  F+   ++L    T  ++ +   P    E   
Sbjct: 799  QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 857

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946
            ++ Q +  +     ++  +P I+++      L E   G  F +   +VA    + Q+  D
Sbjct: 858  IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 916

Query: 3947 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4004
            V+ R   L          ++ + +  I   +++   +L  P     + E +++++ E + 
Sbjct: 917  VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 976

Query: 4005 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            +   +++ Q     L    +EM   S     +IS K  Q + +++   W+ + + + E  
Sbjct: 977  LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1032

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4123
             KL + M    K      +L   + +   F+++ E P + D  ++K+Q +    +  +I 
Sbjct: 1033 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1091

Query: 4124 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4182
             +Q  L+ V N G + I    EP+    ++  + ELN+ WD + +    R + L+  ++ 
Sbjct: 1092 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1150

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
             V  Q  L  + +W+  A  +           + +++ +EE+K+ K EA Q++ +++ L 
Sbjct: 1151 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1210

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4302
                 ++ +    + +  ++  L  L   +  L  R+  +   LE       +    L++
Sbjct: 1211 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1269

Query: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4362
               WL   E  L   + + G  + I   L     L+N +   +     +      L +  
Sbjct: 1270 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1326

Query: 4363 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4422
              +E  N   +LE  N RW+ + E+  +R++ L+ +++ A+     +  +Q+ LT  ++ 
Sbjct: 1327 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1384

Query: 4423 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4478
            L A          +P+ A++   +  ++ +   + EE     M+K  Q      K A   
Sbjct: 1385 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1431

Query: 4479 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4538
            +   I+  ++K + V  K                 F   LQ+    L + +  L      
Sbjct: 1432 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1483

Query: 4539 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4598
            S+  + V  Q++        ++  + ++  + KTG  +    Q ++   +   + +++  
Sbjct: 1484 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1543

Query: 4599 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4658
            + ++  ++ ER + L+   K +++  +  + L EWL  ++  L     +   P  + +++
Sbjct: 1544 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1603

Query: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4718
            A  K  QK +  +     +    G +L  KT L      ++D LS L   W  +  ++ E
Sbjct: 1604 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1661

Query: 4719 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4778
              N L E       F   +  +  W+ + +  L E +             D  K  + EL
Sbjct: 1662 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1716

Query: 4779 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837
                  V + +  A  L+    D     V+ Q+ EL+ R+  +      K  +    L++
Sbjct: 1717 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1774

Query: 4838 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4896
             E+F+S +  LLE L AE +Q     GV   +ED  + + + ++  +K+L ++   L + 
Sbjct: 1775 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1829

Query: 4897 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4954
             T                          R  E +   +Q  Q   +AL  L +  +++ L
Sbjct: 1830 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1865

Query: 4955 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5004
            E    W Q+          L D +K++     P++  ++K +  E Q   EE+   +   
Sbjct: 1866 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1925

Query: 5005 DKVTKTYKRRAADPSSLQ 5022
            + +++     A +P+ +Q
Sbjct: 1926 EGLSEDGAAMAVEPTQIQ 1943



 Score =  221 bits (564), Expect = 1e-56
 Identities = 112/232 (48%), Positives = 154/232 (66%), Gaps = 5/232 (2%)

Query: 30  KDERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRM 88
           +DER+ VQKKTFTKW+N    K  K H+ +L+ DL+DG  L+ LLE L+G  LP+EKG  
Sbjct: 2   EDEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 61

Query: 89  RFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTG 146
           R H L NV  AL  L+   V LVNI + DI DGN KLTLGLIW IILH+Q+ ++  ++  
Sbjct: 62  RVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMA 121

Query: 147 ESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV- 205
             +  ++++ LL W +Q+T  Y  +   NFTT W DG   NA+IH +RPDL D N+V   
Sbjct: 122 GLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQ 181

Query: 206 QSNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 256
           QS    LEHAF +A  ++G+ +LLDPEDVD + PD+KS++ Y++SL+   P+
Sbjct: 182 QSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 233



 Score =  205 bits (521), Expect = 1e-51
 Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)

Query: 3466 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3525
            ++H  H  Q +++  +     +   K   +S   ++Q  Y+   + + S           
Sbjct: 260  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 318

Query: 3526 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3572
             K FG    E EV L  +   + + LS L   + + +   +  +++ V+++         
Sbjct: 319  DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 378

Query: 3573 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3629
             D+   +  V   L  G +L+   + + DE   +Q+++  + +R++ +   S +    L 
Sbjct: 379  MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 438

Query: 3630 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3687
            + L   +  +   +EL  WL K E      E + L    E+  +   + K L+++ +  +
Sbjct: 439  RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 496

Query: 3688 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3747
              ++SL  +   + E     A   LE+ +    +R+  +      +   +   +L+ Q+ 
Sbjct: 497  VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 556

Query: 3748 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3807
             +      +W++E E                     V K  T       +++  L K   
Sbjct: 557  TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 596

Query: 3808 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3867
             ++ A  E++KQSM K     LK  D +  + ++   Q  + ++ ++ F   ++ L   L
Sbjct: 597  -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 650

Query: 3868 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
             ++ + ISQ      P+L   T+ +         +++ +H    +++    PQ       
Sbjct: 651  EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 701

Query: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984
                 +++ +  D+       +++KR   LD  I++   +  + + +L+S E  + R   
Sbjct: 702  -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 745

Query: 3985 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
                      +KE+++  +    +   KLQ    + +   E+M+      ++ ++A +++
Sbjct: 746  -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 794

Query: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4103
               +Q+   W     L+ ER    L+       F+     L       +++++       
Sbjct: 795  QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 853

Query: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4163
            +P+ +K Q +  +     + GLQ +++    L  + IA   +   P+    +D    A+ 
Sbjct: 854  EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 907

Query: 4164 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4217
            +  K     +   E+ +Q        ++YQ+ + A+  WV  +  KL+      TD E +
Sbjct: 908  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 967

Query: 4218 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4277
            +Q++ EL+  +S   +QQ  +  L+   + + KK   E  +   Q    E++  W  L  
Sbjct: 968  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1026

Query: 4278 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4337
            +++    KLE  +  L + Q+ +  L  W+   +  L E+ P  GD + ++ +L +  +L
Sbjct: 1027 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1086

Query: 4338 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4397
             +D+   Q ++ +VN+ G  +   +  E AS L+ +L+ LN +W ++ ++   RK+ L G
Sbjct: 1087 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1146

Query: 4398 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4457
             L +      ++ ++ +W+T  E   L        P+  ++ +          + KE   
Sbjct: 1147 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1206

Query: 4458 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4517
            K L +    ++A+ P  A+  + +++  L   ++ + T+LN +   LEE      E  + 
Sbjct: 1207 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1266

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
            L+    WL + E  L          + +   +D  +        +  QI  L +T T   
Sbjct: 1267 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1326

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637
               +     LI   L +  SRW ++ +  V R + L+ + + A++  ++   + E L   
Sbjct: 1327 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1381

Query: 4638 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4686
            +K L + +       ++  +  KI++ L  H    +E +K    K +     ++   + K
Sbjct: 1382 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1441

Query: 4687 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4746
                      KL D+  + R     +  K    + +L+E+ +   +    L AL      
Sbjct: 1442 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1480

Query: 4747 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4805
             E +  E + V   ++  +NL        K L +  S V+ + ++ R++++  + ++   
Sbjct: 1481 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1532

Query: 4806 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4865
            +  ++  L   +  + A    ++ +LE  L+ + +    ++ L EWLA  +  L     +
Sbjct: 1533 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1592

Query: 4866 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925
                  L + +   K   K++E+++  L   T +G+ +  +      T ++  ++++ + 
Sbjct: 1593 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1651

Query: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985
            +  V + A++    L      +    + ++ +  W+  A+T L + +K+   Q+ + +K 
Sbjct: 1652 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1711

Query: 4986 LIAE 4989
            L AE
Sbjct: 1712 LKAE 1715



 Score =  184 bits (467), Expect = 2e-45
 Identities = 494/2698 (18%), Positives = 1056/2698 (39%), Gaps = 384/2698 (14%)

Query: 1170 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1229
            KLK +N  L  T+          T+  EEE +  D  +++  +   K  + ++++++   
Sbjct: 448  KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 499

Query: 1230 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1289
            ++L   +     + DE    +    L+     E+   L +RW N+    ++R   L+ I 
Sbjct: 500  NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 549

Query: 1290 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1347
              LK+ R T        W+ + E    KI     ++   + + L +  +L +++E K+  
Sbjct: 550  -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 608

Query: 1348 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401
            M +     +   +T+K+  +   T      +    D+  +   K     S A    Q  +
Sbjct: 609  MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 668

Query: 1402 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1454
               T    + T+ T+    +K A + L     ++K   +++ E ++ ++    EL  W++
Sbjct: 669  TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 728

Query: 1455 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1504
                 L+  E     K G     K+K+++   E + K  +L +A ++ Q  + +  +   
Sbjct: 729  RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 788

Query: 1505 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1547
                 K   E+ N         L +++  L+   N++ F   L+QL++  T+ +  +K+ 
Sbjct: 789  NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 848

Query: 1548 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1594
                 E   +  + +  K+++  +  L  Q E   I        G    F+  D      
Sbjct: 849  PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 908

Query: 1595 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1639
             +       Q++++ELQ           Q +  A+   V+ +E   K +  +LS  D  +
Sbjct: 909  HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 966

Query: 1640 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1699
            +EQ+L E  ++  Q +L+ +QS       ++T +KE ++K  +     E   K ++  + 
Sbjct: 967  MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1016

Query: 1700 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1759
            +    K       +H Q +E+     Q    +        +   + E DV  +       
Sbjct: 1017 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1071

Query: 1760 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1819
             ++  +K   Q   ++S  Q +  +  S     +K      PE   +L+  +KEL   ++
Sbjct: 1072 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1131

Query: 1820 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1879
                +   + +      E+      D +E   W+ Q+E+E    +      + L   ++ 
Sbjct: 1132 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1191

Query: 1880 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1939
             K   E+    +  ++ +T S N V+  A   ++              ++++L+  T  +
Sbjct: 1192 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1239

Query: 1940 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1999
            + L   C  L    K L + +  + +    LL+ L+     A+K L+E        ++ +
Sbjct: 1240 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1280

Query: 2000 LEETKALQG---QISSQQVAVEKLKKTAEVLLDARGSLLPAKND-------IQKTLDDIV 2049
            L+ T+ + G   +IS    ++E L + +E   +    L     D       I + L+   
Sbjct: 1281 LKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFN 1340

Query: 2050 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-------EQGQVPL 2102
             R+ +L +    R + L+ ++  +   +  L  + + +  ++  L        +  Q+P 
Sbjct: 1341 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQ 1400

Query: 2103 NSTALQ-DIISKNIMLEQ---DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2158
             +  +Q D+ S  I LE+      G++++   +++      +  D S    L  K  +  
Sbjct: 1401 EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE 1460

Query: 2159 ARFSEASHKHKETLAKMEELKTK--------------VELFENLSE---KLQTFLETKTQ 2201
             R  E+     E    +  L+TK              V L+++LSE   +++  ++T  Q
Sbjct: 1461 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 1520

Query: 2202 ALTEVDVP-------------------GKDVTELSQYMQESTSEFLEHKKHLEVL----- 2237
             + +                       G  VTE  Q +++      + +K + VL     
Sbjct: 1521 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1580

Query: 2238 ---HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL 2294
                 L K  +  G+PS+    +       K+ ++ +  +K   E   + +  L   + L
Sbjct: 1581 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1640

Query: 2295 VKSLKS-----WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2349
            V+   S     WI  T++          AE+    L + +K  E +      I K     
Sbjct: 1641 VEDKLSLLNSNWIAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1690

Query: 2350 ISLCNLISAVTTPAKAIAAVKSGGAVLNG-----EGTATNTEEFWANKGLTSIKKDMTDI 2404
             +L +  S    P +    +K   A LN      + T        AN+G           
Sbjct: 1691 DTLLD-ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----------- 1738

Query: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2464
                +    L++ +I+ELN + + +    +   A +  L+++ +  +  Q+   P + E 
Sbjct: 1739 ----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLEPLEAEI 1793

Query: 2465 VKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2523
             +    + + F  ++ + N   V+EL  +   L +   D  +    K     + +K   L
Sbjct: 1794 QQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1853

Query: 2524 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2583
              L   R++K  E S+   Q++     L + L + E  ++ L P   D   +    +++Q
Sbjct: 1854 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQ 1912

Query: 2584 ILLQEFATRKPQYEQLTAAGQGILSRP-------------GEDPSLRGIVKEQLAAVTQK 2630
               +E    + Q E L+  G  +   P              +    R +   Q+  V ++
Sbjct: 1913 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1972

Query: 2631 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2690
                T  +      ++ + V ST Y + +  +S  L +++  L++    +   + + +Q 
Sbjct: 1973 ----TMMVMTEDMPLEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 2027

Query: 2691 ETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQLEGILKSFK 2742
            E+ + +K  +QQ   +I +  +  +  +AL        VK +   ++L  Q E + K +K
Sbjct: 2028 ESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2085

Query: 2743 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH-PISAKLDVLESLIK 2801
            D + + +  V+  +        F Q   + + +L   +  +N  H      L  L+  I 
Sbjct: 2086 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2145

Query: 2802 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERE 2861
              +   +TL           A GE ++ ++  ++ + LQ +L ++   W    KQ+ +R+
Sbjct: 2146 QRQTVVRTLN----------ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2195

Query: 2862 NKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE---NSIAKLKSLQKEM 2918
             +L+E      +++  +     W+++  +N+  I   L+P + +     + ++K L +E+
Sbjct: 2196 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLEQVKLLVEEL 2252

Query: 2919 DQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK-------------------------- 2951
                G+++ LN T   +L    I  E     ENK                          
Sbjct: 2253 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2312

Query: 2952 ----SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-----SKRQLQCAKEQLDIH 3002
                 L +K++ + EQL+     L  +  + + + + ++E      + ++    +Q D+ 
Sbjct: 2313 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2372

Query: 3003 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD---------SKGTS 3053
            + L    +  K     Q  ++ L+ L  +     RL Q+L  +  D         +  T 
Sbjct: 2373 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2432

Query: 3054 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3113
             V L  + +  + + +S+   E  S L  ++  +  F     E+    +  D  + S   
Sbjct: 2433 TVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2490

Query: 3114 VGRDAETLQ----KQKETIKAFLKK---LEALMASNDN-ANKTCKMMLATEETSPDLVGI 3165
            +  D E +     KQK T++   ++   LE L+ +  N  NKT      T  T       
Sbjct: 2491 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD------ 2544

Query: 3166 KRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVG 3225
               +E +  Q +++ +  Q R +Q+   +K   ++    +E   +L +A    ES     
Sbjct: 2545 --RIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2602

Query: 3226 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3285
               + I +++   K   K ++   Q      N L   L++  + +  T+ +    +++NA
Sbjct: 2603 YTVDAIQKKITETKQLAK-DLRQWQTNVDVANDLALKLLRDYS-ADDTRKVHMITENINA 2660

Query: 3286 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----ANQKPPSAE-F 3339
             W++++K+V++R A L+E      +F   LE  L+W+ + E        A +K    E  
Sbjct: 2661 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2720

Query: 3340 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEA 3398
            K VK  +++ + LQ  ++        +    +KI  + E +D   +L ++L  ++ +W  
Sbjct: 2721 KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 2780

Query: 3399 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3458
            L  K+      LE  S   ++ H +L+ L  WL   +  L    PIG     +++Q   H
Sbjct: 2781 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 2840

Query: 3459 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3518
            +A + ++      +   +S  +++++  + +  + ++    + +   +  +E++ + + L
Sbjct: 2841 RAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPEERAQNVTRL 2895

Query: 3519 LQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3577
            L++         E   +   +W  ++ + L +L     +T+ L     +L++ Q +++  
Sbjct: 2896 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKG 2950

Query: 3578 K-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3634
              Q V   L++ L              QD LE +KA   +I  L  +V+   + A QL
Sbjct: 2951 SWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHVNDLARQL 2994



 Score = 38.9 bits (89), Expect = 0.14
 Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)

Query: 608  VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666
            +Q+LL W+     +L R    G D P+V+       +VHRA +  E   KE  I     T
Sbjct: 2806 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2860

Query: 667  APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 726
              + LT  + L  LE  Y         + R L        RA N +  L  K+ EEV  +
Sbjct: 2861 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2906

Query: 727  WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 774
            W + N        + A+  R++D+  E ++ +QE  ++L L+   A +
Sbjct: 2907 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2947


>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
          Length = 3562

 Score =  325 bits (832), Expect = 1e-87
 Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)

Query: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2238
            ++ QT LE     L   +   +   E+S  ++    +F  H+ ++            +L 
Sbjct: 219  DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 278

Query: 2239 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297
               K I +  L  D+   V E+ N L+ +++ +     EK+  +   +  +D     +K 
Sbjct: 279  LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 336

Query: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
            L  W+ +T ++   ++     E LG  LED K+  ++  +   ++++      SL +++ 
Sbjct: 337  LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 392

Query: 2358 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2415
             V   +   A AA++    VL            WAN            I    ED  +LL
Sbjct: 393  VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 431

Query: 2416 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2475
            +D        L K Q+  EE      WL +      K   T      E + + +++    
Sbjct: 432  QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 483

Query: 2476 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2531
            +A+L   KQ++ K+  LK  L   L+    T +   W        D+  Q+L + T    
Sbjct: 484  KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 543

Query: 2532 QKLEESSNNLTQFQTVEA------------------------------------------ 2549
            Q +  +  +LTQ   +E                                           
Sbjct: 544  QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 603

Query: 2550 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605
               +L  W+   E ++ S    +       +  +++V  + +E A +  + +  + + Q 
Sbjct: 604  DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 663

Query: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665
            ++ +   +      +K+    +  +W      LS+R +W++        + + L+ L   
Sbjct: 664  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 722

Query: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2724
             +  +N L       + P A+  QL+  +     +   + QI+  +      S  +KE+ 
Sbjct: 723  TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 778

Query: 2725 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2780
                +L A+         + F DV+ + E  +Q +        ++Q+     + W+   +
Sbjct: 779  QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 836

Query: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840
             + +         +++E  + + +    +L  Q           + +  K         Q
Sbjct: 837  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 896

Query: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
             +   I+  W   + Q+ E   KL+E + K  K +  ++TL  W+ +    L+E      
Sbjct: 897  SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 952

Query: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2949
            PA G++ I     L+K++ Q   +V  +     SL SV E  +++  +           E
Sbjct: 953  PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1007

Query: 2950 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3009
             K L  + D + +Q++++K  L+   +K    Q+   E    +  A+E+    D      
Sbjct: 1008 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1061

Query: 3010 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3069
            +  K    LQ   + ++  K +    K     L+ E+ +S       +  E + +E  TL
Sbjct: 1062 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1120

Query: 3070 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3129
            +      C+ L  K + +        E+ S   + +  L+ +    +  E +    E I 
Sbjct: 1121 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1180

Query: 3130 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3186
              L  LE LM  S DN N+    +LA   T   ++   I  +LE  + +  +L + A  R
Sbjct: 1181 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1238

Query: 3187 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3237
            ++ +E +I+  +E    L   +E    + K      A++ + +Q P   E + I   L  
Sbjct: 1239 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1296

Query: 3238 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3297
             ++  +E  +  QGK+     L Q  I  A K          L DV+ +++ L +K A  
Sbjct: 1297 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1344

Query: 3298 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3357
              +LQE+ +     +  L +L              +  S E +VV++Q+     L + L 
Sbjct: 1345 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1390

Query: 3358 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3417
            + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +QLE    ++
Sbjct: 1391 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1450

Query: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3477
            ++  + +  L EWL   +  L     +    S L+ ++A  KA + +I     HL     
Sbjct: 1451 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1510

Query: 3478 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3537
            +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + F ++   + 
Sbjct: 1511 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1569

Query: 3538 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595
             W+ +    L  S+        + L + ++EL  ++  +   +      + N  +  ++ 
Sbjct: 1570 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1629

Query: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655
               ++  +  +  AI  R K  T  ++   K LEQ     ++L          L+ +E E
Sbjct: 1630 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1677

Query: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715
            +   +   LK E+ +      K++ ++  N   + + L    +    +   R RE ++  
Sbjct: 1678 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1727

Query: 3716 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775
                  ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL SL + R E+
Sbjct: 1728 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1787

Query: 3776 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831
               +   +LQ +K     + R  + +  D    +        S+  ++   K       N
Sbjct: 1788 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1847

Query: 3832 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3886
            +  I  +  E  + +     L ++    TY      +   L E + +++     A ++E 
Sbjct: 1848 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 1907

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3945
            L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     D  + ++ +
Sbjct: 1908 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 1967

Query: 3946 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4002
              K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  K K  + E 
Sbjct: 1968 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2025

Query: 4003 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4062
            ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W+ +   + +
Sbjct: 2026 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2078

Query: 4063 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4122
            R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E  + + EE+
Sbjct: 2079 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2137

Query: 4123 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4178
               Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A  ++  ++E 
Sbjct: 2138 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2195

Query: 4179 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4234
             ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    +++ +     +
Sbjct: 2196 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2252

Query: 4235 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4278
            Q ++E +  + + L K K   +  K  ++D   E K +   L+E                
Sbjct: 2253 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2312

Query: 4279 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4316
                         ++ ++    KLE   +L+    AL  F  A  EL  WL+  + ++  
Sbjct: 2313 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2372

Query: 4317 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4375
            Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA  +  +++E
Sbjct: 2373 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2432

Query: 4376 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
             +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + K      + 
Sbjct: 2433 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2492

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4495
             ++++    ++       +           ++L          +     N+   W S+  
Sbjct: 2493 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2552

Query: 4496 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4549
            +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+    V   +
Sbjct: 2553 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2612

Query: 4550 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4608
             + +    E+ +H +    LD+     L+      D VL++  L ++  +W ++ ++ + 
Sbjct: 2613 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2672

Query: 4609 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4668
                L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q   H+ F++ L
Sbjct: 2673 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2732

Query: 4669 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4709
              K  V  +T  T                    R L  +    +    L     E+  +W
Sbjct: 2733 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2792

Query: 4710 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4767
            + +   S + Q K++E L    +  +A   L   L + E      QPV GD  ID + + 
Sbjct: 2793 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2851

Query: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
            ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+ +       
Sbjct: 2852 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 2904

Query: 4828 QTRLEAALRQAEEFH 4842
            Q  +E  +RQ  E H
Sbjct: 2905 QVAVEDRVRQLHEAH 2919



 Score =  316 bits (809), Expect = 5e-85
 Identities = 548/2809 (19%), Positives = 1128/2809 (40%), Gaps = 353/2809 (12%)

Query: 1839 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1898
            L+++     E   WL  +E  L+     ++D+  +  +    + +  D+ +H+G +  I 
Sbjct: 218  LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 277

Query: 1899 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1958
              G++++   K     +           EVQ +++    R+  L        +NL  ++ 
Sbjct: 278  QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 327

Query: 1959 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2018
              Q+ +     L   L   E    K   EP+  D ++L+RQ+++ K LQ  +  +QV V 
Sbjct: 328  DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 385

Query: 2019 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2077
             L     V+ ++ G    A  + Q K L D   R+ ++ +   +R   LQ  L +   + 
Sbjct: 386  SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 442

Query: 2078 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2131
            +       W+   E ++ +     +++T  +D       + K  +L+ D+  ++ S+  +
Sbjct: 443  EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 497

Query: 2132 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2190
                +  + T  + S     +A + + +  +     K +++ A++ +  T  +   +L++
Sbjct: 498  YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQ 555

Query: 2191 KLQTFLETKTQALTEVDVPGKDVTEL-----SQYMQESTSEFLEHKKHLEV----LHSLL 2241
               T +ET T   T   +  K   E       Q  ++ T +  E +K L+V    LHS +
Sbjct: 556  T--TVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-EIRKRLDVDITELHSWI 612

Query: 2242 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2278
               S   L S +  +  K  N S              +KF++++D  +  +         
Sbjct: 613  TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 671

Query: 2279 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2330
                +++    EQL++    F  L+    +W++     +         E +  + E+  K
Sbjct: 672  GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 731

Query: 2331 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2389
            +Q      TP       S + +C + ++ ++     I  +K     L  +G         
Sbjct: 732  IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 778

Query: 2390 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2447
              +G   +  D    ++ ++ +   ++ +  EL T    L   + QE  SA+  W+Q+ +
Sbjct: 779  --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 835

Query: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507
            +T     Q    TD E ++ ++ + ++ ++ L++  + +  L   + E+ ++ P +  + 
Sbjct: 836  ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 893

Query: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567
            +++    EI+ +W++L+   ++  QKLEE  N L + Q     LK+W+ E ++ +    P
Sbjct: 894  KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 953

Query: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2627
               D  +L  Q +Q ++L+ +  T +P    +   GQ I +    +P     ++ +L  +
Sbjct: 954  ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1011

Query: 2628 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2687
              +WD +  Q+  R + +   + K+   Q  L  + + ++  + +          PD + 
Sbjct: 1012 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1071

Query: 2688 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2745
            + +E  ++ K+E QQ++ ++K+   L E +++++ +    A+  L ++LE +  +++ + 
Sbjct: 1072 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1128

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2798
             +     + L+   A  H+          WL+       T +     +  IS  LD LE+
Sbjct: 1129 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1188

Query: 2799 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2842
            L++  +D        ++TLT    M E    E E    + +   + A++ Q         
Sbjct: 1189 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1248

Query: 2843 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2874
                   L+ I+ +    +KQ+              +   K++        SLE+  K+ 
Sbjct: 1249 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1308

Query: 2875 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2927
              KE  + +   ID  Q  L+++  KF L   PA  E  + + K +  E+  H   +E  
Sbjct: 1309 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1368

Query: 2928 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 2975
                      LN+  N   S+ E+  EV  V    + ++QK     +Q  + K   E +T
Sbjct: 1369 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1423

Query: 2976 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3031
                 + E+     E K+QL+ C K    +   +           M  T++ +++ +   
Sbjct: 1424 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1483

Query: 3032 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3087
            +D      K   +++  +    K  ++V   ++T+  +  TL   V++K S L +    +
Sbjct: 1484 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1540

Query: 3088 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3143
                  + N + E       FD  +D +      A+TL  + E  K   K+ + L     
Sbjct: 1541 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1599

Query: 3144 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3196
              N     + +T + + +L+  + D   + +  Q ++L  R  A   +++       +K 
Sbjct: 1600 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1659

Query: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
            LE+F S +++   LL+  E   E Q  V ++ E  N+ +N          E  +G  +++
Sbjct: 1660 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1704

Query: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
               G  L Q        + ++     +  +   L    +QR  +  E      +++   +
Sbjct: 1705 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1764

Query: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3373
             LL  + D E+ +A+   P  E K+        K + R L  +K  +  ++R+ E +   
Sbjct: 1765 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1816

Query: 3374 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3417
              A   EP  ++++ K+   ++S++     LN A+            T +  LE IS V 
Sbjct: 1817 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1874

Query: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3474
              +   +  +++ L  +E+ L   +        L +Q    K ++D +   +  +   H 
Sbjct: 1875 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 1934

Query: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3534
              +          R       S+LDF    + ++ +    R     +++   + F  D  
Sbjct: 1935 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 1991

Query: 3535 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3594
                WL E    L K  + +      +K    L+ LQ+ I  R+  V      G E+++Q
Sbjct: 1992 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2049

Query: 3595 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3654
            ++  +  I+Q+KL ++  R++++ K  +D  K LE+   +         E   WL++ + 
Sbjct: 2050 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2108

Query: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3712
             + S   +  K ++  +   + K L +E    + +L  LNE    +L   P    E   L
Sbjct: 2109 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2168

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3765
            E  + + N ++  VS  + +K  EI+A I        + +  ++  +  L W++    +L
Sbjct: 2169 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2228

Query: 3766 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825
                     Q        VQ+T      +  D+ + L K  H       +   Q +K+KL
Sbjct: 2229 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2280

Query: 3826 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3871
            + +   +  + ++  E R  Q + A              +LV Q   T E     L    
Sbjct: 2281 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2340

Query: 3872 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3914
            S++ ++PA A              L  + ++ Q+    +   + E+I + K  +  + + 
Sbjct: 2341 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2400

Query: 3915 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3962
             PQL EL           S  E  +I  ++       + +++E ++ R   L+E +  ST
Sbjct: 2401 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2460

Query: 3963 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4019
            Q+    ++ +Q+L      +E  ++ P     V+ I+++I+E K ++ D+ + Q   +  
Sbjct: 2461 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2517

Query: 4020 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4079
                 +++ R    D       + + ++     W +IH  V EREA L +   L ++F  
Sbjct: 2518 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2573

Query: 4080 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4135
            D    +  + + +     L+D      +++  +   E +++  D LQ E+    D+  NL
Sbjct: 2574 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2632

Query: 4136 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4191
                   L +  G  D  ++++ +D +N  W  L K   +    LE +     +    LQ
Sbjct: 2633 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2692

Query: 4192 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4233
             +  W+ +   +L+  +PIG D   V++Q +  + FK E                    +
Sbjct: 2693 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2752

Query: 4234 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4292
            Q +E +E+L  +   L  +   ++    ++    E+   W+ L     + Q K++  L  
Sbjct: 2753 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2812

Query: 4293 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
            L + Q A DEL   L   E +    +PVG     +++  L K   L+ ++   +  V  V
Sbjct: 2813 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2872

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4400
            N     L          NL + LE LN RW+ +    E R +QL  A R
Sbjct: 2873 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 2920



 Score =  313 bits (803), Expect = 2e-84
 Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)

Query: 2373 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2432
            G+ L G G  +  EE       T +++ M  ++  +E L +   +K + L+  L  LQ  
Sbjct: 280  GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 331

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2492
             ++   +  WL K  +   K ++ P   D E +K QV+Q+K  + +L+Q   +V  L   
Sbjct: 332  -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 390

Query: 2493 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2552
            +  + E + D   A   +Q L  +  +W  + + T DR   L++      +    +    
Sbjct: 391  VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 449

Query: 2553 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2611
             WL EKE  V+ +      D N + +  Q++ +L  +   +K    +L +  Q +LS   
Sbjct: 450  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 508

Query: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2654
            ++ S+    +  L    + WD+L  +L      I QA+  +                 T+
Sbjct: 509  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 568

Query: 2655 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2696
             Q L++   ++L            +D+++   L V         T  +A+ Q  E A   
Sbjct: 569  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 628

Query: 2697 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2736
            K+            I++EK +         + AQAL E + +  V  + +K + S QL  
Sbjct: 629  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 687

Query: 2737 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2795
                F  +  +  N +++  +  A  +Q QQ+ +     + T  E   K  P + ++   
Sbjct: 688  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 742

Query: 2796 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2855
            ++S +K  KD    L+      E+   + +++ LK +G     L         ++     
Sbjct: 743  IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 800

Query: 2856 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2912
             V+ RE +L+   +    ++Y+E +  +  W+ + +  L   +  +   E  E  + +L+
Sbjct: 801  DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 860

Query: 2913 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 2972
            +LQ  + +    +  L+ T      V E+ K+  ++ ++    + + +  +       L 
Sbjct: 861  ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 914

Query: 2973 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3024
               QK +E     ++ +  +Q  K+   ++D+       +LG      K L   +     
Sbjct: 915  EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 974

Query: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3084
            +Q ++  ++      Q +  EA + +  S +  +++ +  +   + QQV  +   L+  L
Sbjct: 975  IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1033

Query: 3085 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3144
            +     Q  + EM     + ++E        +  + LQK  E +K          A  + 
Sbjct: 1034 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1084

Query: 3145 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3196
              K  K+ L TE  +  +          +K++LE L+     L  R   + + +E     
Sbjct: 1085 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1144

Query: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
              E  S L++ +  L + E   ++   +    E I++ L+  +   +      +     +
Sbjct: 1145 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1200

Query: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
              L Q L          + +  +L+  N+RW+ L+++  +R   L++++      Q A E
Sbjct: 1201 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1251

Query: 3317 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3373
            +  S  +  E L    K  +A    KV  AQ+ QE + +Q  L   + ++E +K+  +  
Sbjct: 1252 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1311

Query: 3374 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3432
                    ++ +  K+L  +  ++      A    R  E   +        L+ +   L 
Sbjct: 1312 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1363

Query: 3433 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3492
             +E + V  E + +Q   L   +  +K+L +        +   +  G+ +      E+  
Sbjct: 1364 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1416

Query: 3493 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3552
             +  ++   ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S 
Sbjct: 1417 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1476

Query: 3553 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
             +     L  + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + +
Sbjct: 1477 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1535

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
             +  +T  + +    L +  +         + +  W+  ++ + L  E++  K ++    
Sbjct: 1536 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1593

Query: 3673 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732
                K LK E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  
Sbjct: 1594 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1648

Query: 3733 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3792
            K  +    +   +QF+              +KL+   +  ++Q     +    K    + 
Sbjct: 1649 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1696

Query: 3793 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3851
              ++  + +L++ G  +    ++E K + +K K   +   ++ +  + S+R  +      
Sbjct: 1697 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1754

Query: 3852 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3911
               Q+    ++L   L + +  ++ LP P            + R+++E+  E +   +++
Sbjct: 1755 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1803

Query: 3912 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3967
            N    Q   LS  G   +++   +     + +I+      ++   A    + + T     
Sbjct: 1804 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1863

Query: 3968 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4027
             D  LE        L +   +S  + ++++ ++     + D E L    E+LK   + + 
Sbjct: 1864 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 1923

Query: 4028 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4074
              SG  D   S K              +Q+ L Q+ F WE ++ + ++R+ +    +E  
Sbjct: 1924 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 1983

Query: 4075 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4131
             +F  D       + + + F+R  + P        +  E A+    ++E  DG+ +   +
Sbjct: 1984 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2035

Query: 4132 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4188
            V  L   G E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q 
Sbjct: 2036 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2095

Query: 4189 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4248
             L     W++ A   +AS+       + +K+++E++K    E   +Q  +++LN     +
Sbjct: 2096 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2154

Query: 4249 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4303
            L       EE DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L  
Sbjct: 2155 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2212

Query: 4304 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4356
                 L WL+     L    Q    G     E E+A        V A Q  VE +   G 
Sbjct: 2213 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2264

Query: 4357 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4384
             L +     +   ++ KLE L+  W+ V                                
Sbjct: 2265 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2322

Query: 4385 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
                  ++T   K ++  +L         F+    +L  WL+  ++ + + + + G  E 
Sbjct: 2323 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2382

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4494
              E +          E +    + L+   Q +  +   + A T I   I  ++ +W+ V+
Sbjct: 2383 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2442

Query: 4495 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4554
              L  R+ +L E L  + ++  + ++    L QA   L         +D +  +I E K 
Sbjct: 2443 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2502

Query: 4555 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4614
             A ++   +  +   +     L       D   +  +  ++ + W  + +R+ ER  +L+
Sbjct: 2503 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2562

Query: 4615 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4668
            +  +  +QF     K + WL E+E + +       +  +  D   +K  + Q ++ Q  +
Sbjct: 2563 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2622

Query: 4669 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728
             A   VY   +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +  
Sbjct: 2623 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2682

Query: 4729 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4782
               +   +LQ L+ WL   + +L+   P+ GD   V    D H+AF++EL  +       
Sbjct: 2683 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2742

Query: 4783 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
                           ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   
Sbjct: 2743 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2802

Query: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887
            Q +++  L + +E       L   L +AE        + D       LID  ++ ++K++
Sbjct: 2803 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2856

Query: 4888 EKRAEL 4893
              R E+
Sbjct: 2857 ALRGEI 2862



 Score =  308 bits (789), Expect = 1e-82
 Identities = 502/2696 (18%), Positives = 1071/2696 (39%), Gaps = 346/2696 (12%)

Query: 2650 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2709
            V   +YQ+ L  +   L   ++ L +   +S   + +  Q  T +    ++   + ++  
Sbjct: 216  VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 275

Query: 2710 AQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQM 2768
               L   L    K  E  + E+  Q+  +L S  +  + A    Q          Q Q++
Sbjct: 276  ILQLGSKLIGTGKLSEDEETEVQEQMN-LLNSRWECLRVASMEKQSNLHRVLMDLQNQKL 334

Query: 2769 SRDFQAWLDTKKEEQNKS---HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
             ++   WL TK EE+ +     P+   L+ L+  ++ HK   + L  Q  +   ++    
Sbjct: 335  -KELNDWL-TKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLE-QEQVRVNSLTHMV 391

Query: 2826 NLLLKTQGSEK-AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2884
             ++ ++ G    AAL+ QL  +   W    +  ++R   L++ L K  +  E+      W
Sbjct: 392  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 451

Query: 2885 IDKCQNNLEEIKFC--LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2942
            + + ++ + +I      D  E  +S+ KL  L+ ++++    +  L +    LLS   + 
Sbjct: 452  LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST--LK 509

Query: 2943 KEVVTDENKS-----------LIQKVDMVTEQLH----------SKKFCLENMTQKFKEF 2981
             + VT + ++           L+QK++  T Q+           ++   +E +T      
Sbjct: 510  NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 569

Query: 2982 QEVSK-----------ESKRQLQCAKE---QLDIHDSLGSQAYSNKYLTMLQT------- 3020
            Q + K           + KRQ+    E   +LD+ D     ++  +   +LQ+       
Sbjct: 570  QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV-DITELHSWITRSEAVLQSPEFAIFR 628

Query: 3021 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQ--------VETIAQEHSTLSQQ 3072
            ++ +   LK +V+  +R   +   +  D+  ++  L++         ++I Q    L+ +
Sbjct: 629  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 688

Query: 3073 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3132
              E C  L  +L  +  +QN I   ++Q  + +    +     +   T   +   IK+ L
Sbjct: 689  WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 747

Query: 3133 K----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3188
            K    ++  L        +     +A +E     + +  D  A +    ++    QARE+
Sbjct: 748  KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 807

Query: 3189 QVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3246
            +++     L    +   +      +Q++E           + E + Q+L   +  Q    
Sbjct: 808  ELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSS-- 865

Query: 3247 EPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3304
              LQ +Q  + +L   + + + K+ S  ++  + + +++  RWK L+ ++ +   +L+E 
Sbjct: 866  --LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 923

Query: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3364
            +    + Q+ +++L  WM + +  +  + P   + +++K Q+++ +LL   +   + ++ 
Sbjct: 924  MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLN 983

Query: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3424
             +   G+KI   AEP    ++  +L  L+++W+ +  +   R   L+G         + L
Sbjct: 984  SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDL 1043

Query: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3484
              ++EW+T  E+  +  +       +L++ + + K  +++       +        S+  
Sbjct: 1044 SEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1103

Query: 3485 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKIFGEDEVELMNWLNEV 3543
             +    ++ ++ +L+     Y  +  + + + + L++   C  ++    E +   WLNEV
Sbjct: 1104 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE-KANKWLNEV 1162

Query: 3544 HDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL- 3601
              KL        +TE +     E+  VL     L + + D    N + +L QT  D  + 
Sbjct: 1163 EFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--NQIRILAQTLTDGGVM 1213

Query: 3602 --IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH-STH--EELCTWLDK----- 3651
              +I ++LE   +R++++ + +    K LEQ++Q A+    S H  +E  T++DK     
Sbjct: 1214 DELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1273

Query: 3652 ----------------VEVELLSYETQVLK------GEEASQAQM--------------- 3674
                            ++ +L S+E  + +      G+EA+Q  +               
Sbjct: 1274 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM 1333

Query: 3675 ------RPKELKKEAKNNKALLD-------------------------------SLNEVS 3697
                  +P   ++  + +K +LD                               SL+EV 
Sbjct: 1334 KFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 1393

Query: 3698 SALLELVPWRAREGLEKMVAED----NER-------YRLVSDTITQKVEEIDAAILRSQQ 3746
            S + E+V    R+ ++K   E+    +ER       Y  +   +T++ ++++  +  S++
Sbjct: 1394 SEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1452

Query: 3747 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806
              +  +    W+  T+ +L     +        +++   K    EI + K  +  + + G
Sbjct: 1453 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1512

Query: 3807 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866
              + T   ++E   ++ KL  +  N+  +     E    L   Q  +  F +  + +  W
Sbjct: 1513 EALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1571

Query: 3867 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3926
            + +  +++        E E  + QQ+E   L+ L AE      K++ T  Q   L    G
Sbjct: 1572 IIQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRG 1623

Query: 3927 FS----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 3982
                  ++ +    +  ++ I   +K    ++   + +  QF+  I ++LE LE  +++ 
Sbjct: 1624 DHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ- 1680

Query: 3983 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042
                 ++ + E   + ++E+   +V         + L QRG+ +  R     K    K  
Sbjct: 1681 ----GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIK 1727

Query: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4102
            Q  L         +  L  +R  K L++     ++      L+  + D +  +  L +P 
Sbjct: 1728 QQLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1784

Query: 4103 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4162
             D   +K+     +  +EE++ ++ + +    L  +  A   EP +  + K   E+ S +
Sbjct: 1785 -DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKF 1840

Query: 4163 DSLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSP 4209
                +    +I  + EE M    +            Y   +  V   +      L +   
Sbjct: 1841 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 1900

Query: 4210 IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4269
               D E + +Q E LK  K    Q    ++ ++ +    L+  T   ++  +Q+ L +L 
Sbjct: 1901 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLD 1959

Query: 4270 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIE 4328
              W+ + +   +RQ + + ++    +F + +     WLT  E  L + Q P   +    +
Sbjct: 1960 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2019

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4388
              L +   LQ+ +   Q+ V  +N  G ++I+ S+  +AS LQ KL  LN RWQ V ++ 
Sbjct: 2020 WYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2076

Query: 4389 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVC 4447
              RK++L+        F  ++ +   WL + +   +AS PL  G  +  KE+L     + 
Sbjct: 2077 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLV 2134

Query: 4448 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKL 4504
                 ++   K L + G  +L   P S E   D+  N LK+   +W  V   L E++ ++
Sbjct: 2135 EELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEI 2193

Query: 4505 EEALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFAN 4557
            E  +    +    L+D        + WL+     L + ++P+       F + E ++   
Sbjct: 2194 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI--- 2247

Query: 4558 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------ 4611
             V + +  + E+   G HL  + +K     +K  L  + S W K V RL++  R      
Sbjct: 2248 AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDL 2304

Query: 4612 ------------------------------------SLDDARKRAKQFHEAWSKLMEWLE 4635
                                                SL         F+ AW++L +WL 
Sbjct: 2305 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS 2364

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4695
              ++ + S+  +  D + I   + + K   + L  +    +      ++LK KTS  +  
Sbjct: 2365 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEAR 2424

Query: 4696 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4755
              + D +  ++++WD +      R+ +L E L  S Q+ +A +     L +   +L   +
Sbjct: 2425 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 2484

Query: 4756 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELS 4814
                 +D +   I   K   K+L +  ++V      A +L+   S DD+  V +  + ++
Sbjct: 2485 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 2544

Query: 4815 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT 4874
              W ++      ++  LE   R  ++F   +   L WL EAE T     VL D     R 
Sbjct: 2545 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERL 2601

Query: 4875 LIDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRA 4924
            L D    KE MK+ ++ + E+   T +   +         ++   D    ++  +  +  
Sbjct: 2602 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2661

Query: 4925 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK 4984
            ++ E+   +   +  L ++          L+ LL WLQ  +  L+ +    I  +   V+
Sbjct: 2662 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQ 2719

Query: 4985 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLY 5044
                 H+ F  E+  K+P +    +T +            I + ++   G ++     LY
Sbjct: 2720 KQNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LY 2762

Query: 5045 PSGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5092
                +   E +   V  L+ K        W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 2763 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2818



 Score =  295 bits (755), Expect = 8e-79
 Identities = 474/2585 (18%), Positives = 1053/2585 (40%), Gaps = 294/2585 (11%)

Query: 2534 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2593
            L ES  NL ++QT   ++  WL+  E  +   G +S D  ++  Q    +  + +    +
Sbjct: 211  LMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQ 270

Query: 2594 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2653
             +   +   G  ++            V+EQ+  +  +W+ L     ++   + + ++   
Sbjct: 271  GRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 330

Query: 2654 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA--MNQQLETAQKMKQEIQQEKKQIK--V 2709
              +  L+ L+D L+  + +          PD   + +Q++  + ++++++QE+ ++    
Sbjct: 331  NQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 388

Query: 2710 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2769
               +  D S+    ++  A L  QL+ +   + ++ +  E+    LQ       +  +  
Sbjct: 389  HMVVVVDESS---GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 445

Query: 2770 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2829
              F AWL  K++  NK H             KD  +   +L                   
Sbjct: 446  CLFSAWLSEKEDAVNKIHTTG---------FKDQNEMLSSL------------------- 477

Query: 2830 KTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID--- 2886
                 + A L+  L           KQ   +   LK+ L   LK K   +    W+D   
Sbjct: 478  ----QKLAVLKADLEK--------KKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 525

Query: 2887 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2946
            +C +NL +    L+ +  + S A + + Q  + Q   M  +   T    + V    +E+ 
Sbjct: 526  RCWDNLVQ---KLEKSTAQISQA-VTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 581

Query: 2947 TDE---------NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE 2997
                        +  + +++D+   +LHS     E + Q   EF    KE        KE
Sbjct: 582  PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS-PEFAIFRKEG--NFSDLKE 638

Query: 2998 QLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3057
            +++  +   ++ +       LQ   +S QAL               VE   ++G     +
Sbjct: 639  KVNAIEREKAEKFRK-----LQDASRSAQAL---------------VEQMVNEG-----V 673

Query: 3058 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3117
              ++I Q    L+ +  E C  L  +L  +  +QN I   ++Q  + +    +     + 
Sbjct: 674  NADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKI 732

Query: 3118 AETLQKQKETIKAFLK----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3173
              T   +   IK+ LK    ++  L        +     +A +E     + +  D  A +
Sbjct: 733  QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 792

Query: 3174 KQCNKLLDRAQAREEQVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3231
                ++    QARE++++     L    +   +      +Q++E           + E +
Sbjct: 793  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852

Query: 3232 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKT 3289
             Q+L   +  Q      LQ +Q  + +L   + + + K+ S  ++  + + +++  RWK 
Sbjct: 853  EQRLGELQALQSS----LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 908

Query: 3290 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3349
            L+ ++ +   +L+E +    + Q+ +++L  WM + +  +  + P   + +++K Q+++ 
Sbjct: 909  LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 968

Query: 3350 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ 3409
            +LL   +   + ++  +   G+KI   AEP    ++  +L  L+++W+ +  +   R   
Sbjct: 969  RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1028

Query: 3410 LEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN 3469
            L+G         + L  ++EW+T  E+  +  +       +L++ + + K  +++     
Sbjct: 1029 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1088

Query: 3470 KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKI 3528
              +        S+   +    ++ ++ +L+     Y  +  + + + + L++   C  ++
Sbjct: 1089 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1148

Query: 3529 FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLN 3587
                E +   WLNEV  KL        +TE +     E+  VL     L + + D    N
Sbjct: 1149 LSYLE-KANKWLNEVEFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--N 1198

Query: 3588 GLELLKQTTGDEVL---IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA----RRLHS 3640
             + +L QT  D  +   +I ++LE   +R++++ + +    K LEQ++Q A    + LH 
Sbjct: 1199 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1258

Query: 3641 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSAL 3700
              E L T++DK   +L +Y   +    +A+Q     ++++ +  +++  L+ + + +   
Sbjct: 1259 IQESL-TFIDK---QLAAY---IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN--- 1308

Query: 3701 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ---FDQAADAELSW 3757
                  + +E  ++++++         D   +K++++       Q+   F+Q        
Sbjct: 1309 ------QGKEAAQRVLSQ--------IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1354

Query: 3758 ITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEE 3817
            + E +  L +L    +EQ+   +QL         +   K  ++ ++K+G +I+     E 
Sbjct: 1355 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1414

Query: 3818 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3877
             + + +++  +  +Y+ +    +ER  QLE+   L  +  +    L  WL  T   +++ 
Sbjct: 1415 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1474

Query: 3878 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3937
             A       L  +    +  ++ I + K H+  + + G  L  +   +   +++K     
Sbjct: 1475 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL---- 1530

Query: 3938 TLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE 3997
            +L +     V  RA   +E ++   ++   ++   ++++ I + + Q  ++  E EK K 
Sbjct: 1531 SLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1587

Query: 3998 QISEN--KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4055
            Q  E+  K +  ++  ++P  ++ + +   ++A  G    D   K V+ ++ ++   +  
Sbjct: 1588 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELNHRFAA 1643

Query: 4056 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4115
            I   ++  +A +   ++  E+F  D   L+  ++       +L++   +  + +  +   
Sbjct: 1644 ISHRIKTGKASI--PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 1701

Query: 4116 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4175
            + + +  D LQ+ +               E  +  +K     L +  ++L      R  K
Sbjct: 1702 KELLQRGDNLQQRI-------------TDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1748

Query: 4176 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ 4235
              E      QY+     +   +D    KLAS+ P   D   +K+   EL++ K       
Sbjct: 1749 ALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQKKKE------ 1801

Query: 4236 IEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN-------RQHKL-E 4287
             E+  +  QAE L    +E+     V+   ++L   W  +E +          + H + E
Sbjct: 1802 -ELNAVRRQAEGL----SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE 1856

Query: 4288 GALLALG-----QFQHALDELLAWLTHTEGLLSEQKPVGGDP----KAIEIELAKHHVLQ 4338
              ++ +      +  +     L  +TH    L E + +   P    K  E    +   L+
Sbjct: 1857 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 1916

Query: 4339 N--DVLAHQS-TVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4395
            N  D L   S  ++ ++      ++S+   E   LQ  L  L+ +W+ V +  + R+ + 
Sbjct: 1917 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 1976

Query: 4396 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET---AKEQLNVHMEVCAAFEA 4452
            D ++ + + FH +I+   QWLT+ E+ L  ++    +PE    AK +  +  E+      
Sbjct: 1977 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYL-KELQDGIGQ 2031

Query: 4453 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4512
            ++   ++L   G++++ +  K+  + + + + +L  +W+ V  +L++RK +LEE  N+  
Sbjct: 2032 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2091

Query: 4513 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4572
            EF   L +F+ WL +A+   ++   P      +  ++++ K+   E+   +  + +L++T
Sbjct: 2092 EFQRDLNEFVLWLEEADNIASIPLEPGK-EQQLKEKLEQVKLLVEELPLRQGILKQLNET 2150

Query: 4573 G----THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERG-------RSLDDARKRAK 4621
            G           ++QD   ++N L     +W KV + L E+        + L    K+ +
Sbjct: 2151 GGPVLVSAPISPEEQD--KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2208

Query: 4622 QFHEAWSKLMEWLEESEKSLDSELEIANDP------DKIKTQL---AQHKEFQKSLGAKH 4672
               E  + L+ WL      + ++LEI N P      D  +T++   A+  + ++ L    
Sbjct: 2209 DLEEQLNHLLLWL----SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2264

Query: 4673 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD------TICGKS---------- 4716
             +Y     T    ++   L+ +   ++ +L ELR K        T  G S          
Sbjct: 2265 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 2324

Query: 4717 -----------VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4765
                       +E  + L   +     F  A   L DWL  ++  +   + + GD++ + 
Sbjct: 2325 PVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDIN 2384

Query: 4766 NLIDNHKAFQKELGKRTSSVQALKRSARELIE--GSRDDSSWVKVQMQELSTRWETVCAL 4823
             +I   KA  ++L +R   ++ L  +A+ L     +++  + +  +++ +  +W+ V   
Sbjct: 2385 EMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEH 2444

Query: 4824 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4883
              +++ +L   L+ + ++        + L +A   L      P   DA++  I + K+  
Sbjct: 2445 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2504

Query: 4884 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4943
            K L + +  ++ A  +   +L     D    + H IT      E + A  +   +R++  
Sbjct: 2505 KDLRQWQTNVDVANDLALKLLRDYSADDTRKV-HMIT------ENINASWRSIHKRVSER 2557

Query: 4944 LAGLIAKQEL-------LEALLAWLQWAETT---LTDKD-KEVIPQEIEEVKALIAEHQT 4992
             A L     L       LE  LAWL  AETT   L D   KE + ++ + VK L+ + Q 
Sbjct: 2558 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 2617

Query: 4993 FMEEM 4997
               E+
Sbjct: 2618 LQGEI 2622



 Score =  277 bits (708), Expect = 2e-73
 Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)

Query: 2077 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2136
            Q  L+E+L W+ + E +L+ QG++  +   ++D    +     D+   Q  +  + +   
Sbjct: 222  QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 281

Query: 2137 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2194
            K + T   S    + +Q +M  L++R+        E  + +   +  ++L     ++L  
Sbjct: 282  KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 339

Query: 2195 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2248
            +L TKT+  T   E +  G D+ +L + +Q+       HK   + LE     +  ++   
Sbjct: 340  WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 391

Query: 2249 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2301
            +  D++     T  L ++ K + D      +  ++     Q+ L  +Q L +      +W
Sbjct: 392  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 451

Query: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2347
            + E    V  +  + G +D  + L   +KL               + +SLK   +  + N
Sbjct: 452  LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 510

Query: 2348 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397
              ++      L N      + V    K+ A +    AV   + + T T        +T+ 
Sbjct: 511  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 567

Query: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457
             ++   + H  E+L      K  ++       ++   + + +  W+ +         Q+P
Sbjct: 568  -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 622

Query: 2458 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2513
              A    E   + +++   + E E  +   K+Q+       L+E+  +    A   KQ  
Sbjct: 623  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 682

Query: 2514 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2573
             +++S+W E  QL  +R   LE   NN+  F     QL+Q     E  + +      +P 
Sbjct: 683  EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 741

Query: 2574 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2633
             + +Q +  +  +   +  +PQ E+L       L   G+ P     +     A T  +  
Sbjct: 742  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 797

Query: 2634 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2691
            +   +  R   +      +   +YQ  + ++   +   + KLS      T  + M Q+L 
Sbjct: 798  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 857

Query: 2692 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2751
              Q ++  +Q+++  +       +++S     E +  +   + E I   +K +  +   H
Sbjct: 858  ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 916

Query: 2752 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2811
             Q L+       + Q   +  + W+        +  P     ++L+  +K  +     + 
Sbjct: 917  CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 976

Query: 2812 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2871
                        G+ +  + +    + L+ +L  + T WD   +QV  R+  LK  LEK 
Sbjct: 977  TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1036

Query: 2872 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2930
            +  ++ +  +  W+ + +    E  F    P E + ++ ++K  ++E  Q    V+LL  
Sbjct: 1037 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1096

Query: 2931 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 2989
            + NS+++    + +E +  E ++L      +  +L+ K   LE +   + E     +++ 
Sbjct: 1097 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1156

Query: 2990 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3048
            + L   + +L   +++ G     ++ L  L+   +  +   +Q+ +   LAQ L      
Sbjct: 1157 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1208

Query: 3049 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3106
              G  D L+  ++ET       L ++   +   LE  +Q     + ++  +       D 
Sbjct: 1209 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1268

Query: 3107 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3166
            +L +      DA  + ++ + I++ L   E                ++ EE      G +
Sbjct: 1269 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1312

Query: 3167 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3223
                 LS+     +D AQ + + V    +  ++   F  +L+E  ++L + + H  +   
Sbjct: 1313 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1367

Query: 3224 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3283
              +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +
Sbjct: 1368 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1425

Query: 3284 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3343
               +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + 
Sbjct: 1426 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1485

Query: 3344 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3403
            +++   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++A
Sbjct: 1486 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1544

Query: 3404 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3463
            E     L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +
Sbjct: 1545 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1602

Query: 3464 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3515
            DI              Q+  ++++R D  + +V+ ++      F+ + + I+  + S   
Sbjct: 1603 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1657

Query: 3516 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3569
             EL Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+
Sbjct: 1658 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1715

Query: 3570 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
              E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K
Sbjct: 1716 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1775

Query: 3627 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3683
             L    +    R++     EL     K E+  +  + + L  + A+ A +    +L K  
Sbjct: 1776 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1833

Query: 3684 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3742
            +  ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L
Sbjct: 1834 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 1889

Query: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3802
              +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +
Sbjct: 1890 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 1949

Query: 3803 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3862
                 K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ       
Sbjct: 1950 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 1995

Query: 3863 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3922
               WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S
Sbjct: 1996 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2050

Query: 3923 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981
                 SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + 
Sbjct: 2051 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2109

Query: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041
            +   P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     
Sbjct: 2110 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2167

Query: 4042 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4092
            +++KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   +
Sbjct: 2168 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2225

Query: 4093 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4152
            + +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK
Sbjct: 2226 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2277

Query: 4153 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4177
            + +++L+S W ++N+  ++                                    I KLE
Sbjct: 2278 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2337

Query: 4178 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4231
                    + A   +      + DW+ +    + S   +  DLE + + I + K    + 
Sbjct: 2338 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2397

Query: 4232 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4291
             Q++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L 
Sbjct: 2398 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2457

Query: 4292 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
               Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  
Sbjct: 2458 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2517

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
            N     L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E 
Sbjct: 2518 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2577

Query: 4412 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4465
               WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q
Sbjct: 2578 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2637

Query: 4466 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4524
            ++L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + W
Sbjct: 2638 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2697

Query: 4525 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4584
            L   +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q 
Sbjct: 2698 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2754

Query: 4585 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4635
            +  ++ L      +  + R + V + L          RK+A++ +  W KL     +W  
Sbjct: 2755 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2804

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQ 4660
            + +++L+   E+    D++  +L Q
Sbjct: 2805 KIDETLERLQELQEATDELDLKLRQ 2829



 Score =  226 bits (576), Expect = 5e-58
 Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)

Query: 3299 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3358
            + L E+ ++  R+Q ALE +LSW++  E+ +  Q   S + +VVK Q    +     L  
Sbjct: 209  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 268

Query: 3359 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3416
             +  V  I + G K+  T + +  ++ ++ +Q++LL+SRWE L   +  +   L  + + 
Sbjct: 269  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 328

Query: 3417 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3470
             Q  ++ L+ LN+WLT  E+R   +  EP+G     L+ Q+ QHK L++D+    +  N 
Sbjct: 329  LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 386

Query: 3471 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3530
              H  V + +S    S       ++ +L      +  I   +  R  LLQ  L   +   
Sbjct: 387  LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 442

Query: 3531 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3590
            E++     WL+E  D ++K+      T G   Q   L  LQ+  +L+           LE
Sbjct: 443  EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 488

Query: 3591 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3650
              KQ+ G    + QD L  +K +                          S  ++   WLD
Sbjct: 489  KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 522

Query: 3651 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3710
                    ++  V K E+++    +     + +     +++++  V++    LV   A+E
Sbjct: 523  NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 578

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
             L        ++ ++  D+  +K  ++D   L             SWIT +E  L S   
Sbjct: 579  ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 624

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3826
                ++   + L+ +K   +E  + +    + D  +S   ++     E     S+K+  +
Sbjct: 625  AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 683

Query: 3827 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3886
            ++   +   CQ+ SER   LE   +++  F+   ++L    T  ++ +   P    E   
Sbjct: 684  QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 742

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946
            ++ Q +  +     ++  +P I+++      L E   G  F +   +VA    + Q+  D
Sbjct: 743  IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 801

Query: 3947 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4004
            V+ R   L          ++ + +  I   +++   +L  P     + E +++++ E + 
Sbjct: 802  VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 861

Query: 4005 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            +   +++ Q     L    +EM   S     +IS K  Q + +++   W+ + + + E  
Sbjct: 862  LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 917

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4123
             KL + M    K      +L   + +   F+++ E P + D  ++K+Q +    +  +I 
Sbjct: 918  QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 976

Query: 4124 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4182
             +Q  L+ V N G + I    EP+    ++  + ELN+ WD + +    R + L+  ++ 
Sbjct: 977  TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1035

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
             V  Q  L  + +W+  A  +           + +++ +EE+K+ K EA Q++ +++ L 
Sbjct: 1036 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1095

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4302
                 ++ +    + +  ++  L  L   +  L  R+  +   LE       +    L++
Sbjct: 1096 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1154

Query: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4362
               WL   E  L   + + G  + I   L     L+N +   +     +      L +  
Sbjct: 1155 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1211

Query: 4363 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4422
              +E  N   +LE  N RW+ + E+  +R++ L+ +++ A+     +  +Q+ LT  ++ 
Sbjct: 1212 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1269

Query: 4423 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4478
            L A          +P+ A++   +  ++ +   + EE     M+K  Q      K A   
Sbjct: 1270 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1316

Query: 4479 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4538
            +   I+  ++K + V  K                 F   LQ+    L + +  L      
Sbjct: 1317 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1368

Query: 4539 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4598
            S+  + V  Q++        ++  + ++  + KTG  +    Q ++   +   + +++  
Sbjct: 1369 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1428

Query: 4599 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4658
            + ++  ++ ER + L+   K +++  +  + L EWL  ++  L     +   P  + +++
Sbjct: 1429 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1488

Query: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4718
            A  K  QK +  +     +    G +L  KT L      ++D LS L   W  +  ++ E
Sbjct: 1489 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1546

Query: 4719 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4778
              N L E       F   +  +  W+ + +  L E +             D  K  + EL
Sbjct: 1547 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1601

Query: 4779 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837
                  V + +  A  L+    D     V+ Q+ EL+ R+  +      K  +    L++
Sbjct: 1602 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1659

Query: 4838 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4896
             E+F+S +  LLE L AE +Q     GV   +ED  + + + ++  +K+L ++   L + 
Sbjct: 1660 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1714

Query: 4897 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4954
             T                          R  E +   +Q  Q   +AL  L +  +++ L
Sbjct: 1715 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1750

Query: 4955 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5004
            E    W Q+          L D +K++     P++  ++K +  E Q   EE+   +   
Sbjct: 1751 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1810

Query: 5005 DKVTKTYKRRAADPSSLQ 5022
            + +++     A +P+ +Q
Sbjct: 1811 EGLSEDGAAMAVEPTQIQ 1828



 Score =  205 bits (521), Expect = 1e-51
 Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)

Query: 3466 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3525
            ++H  H  Q +++  +     +   K   +S   ++Q  Y+   + + S           
Sbjct: 145  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 203

Query: 3526 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3572
             K FG    E EV L  +   + + LS L   + + +   +  +++ V+++         
Sbjct: 204  DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 263

Query: 3573 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3629
             D+   +  V   L  G +L+   + + DE   +Q+++  + +R++ +   S +    L 
Sbjct: 264  MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 323

Query: 3630 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3687
            + L   +  +   +EL  WL K E      E + L    E+  +   + K L+++ +  +
Sbjct: 324  RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 381

Query: 3688 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3747
              ++SL  +   + E     A   LE+ +    +R+  +      +   +   +L+ Q+ 
Sbjct: 382  VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 441

Query: 3748 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3807
             +      +W++E E                     V K  T       +++  L K   
Sbjct: 442  TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 481

Query: 3808 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3867
             ++ A  E++KQSM K     LK  D +  + ++   Q  + ++ ++ F   ++ L   L
Sbjct: 482  -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 535

Query: 3868 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
             ++ + ISQ      P+L   T+ +         +++ +H    +++    PQ       
Sbjct: 536  EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 586

Query: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984
                 +++ +  D+       +++KR   LD  I++   +  + + +L+S E  + R   
Sbjct: 587  -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 630

Query: 3985 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
                      +KE+++  +    +   KLQ    + +   E+M+      ++ ++A +++
Sbjct: 631  -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 679

Query: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4103
               +Q+   W     L+ ER    L+       F+     L       +++++       
Sbjct: 680  QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 738

Query: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4163
            +P+ +K Q +  +     + GLQ +++    L  + IA   +   P+    +D    A+ 
Sbjct: 739  EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 792

Query: 4164 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4217
            +  K     +   E+ +Q        ++YQ+ + A+  WV  +  KL+      TD E +
Sbjct: 793  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852

Query: 4218 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4277
            +Q++ EL+  +S   +QQ  +  L+   + + KK   E  +   Q    E++  W  L  
Sbjct: 853  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 911

Query: 4278 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4337
            +++    KLE  +  L + Q+ +  L  W+   +  L E+ P  GD + ++ +L +  +L
Sbjct: 912  QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 971

Query: 4338 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4397
             +D+   Q ++ +VN+ G  +   +  E AS L+ +L+ LN +W ++ ++   RK+ L G
Sbjct: 972  VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1031

Query: 4398 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4457
             L +      ++ ++ +W+T  E   L        P+  ++ +          + KE   
Sbjct: 1032 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1091

Query: 4458 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4517
            K L +    ++A+ P  A+  + +++  L   ++ + T+LN +   LEE      E  + 
Sbjct: 1092 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1151

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
            L+    WL + E  L          + +   +D  +        +  QI  L +T T   
Sbjct: 1152 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1211

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637
               +     LI   L +  SRW ++ +  V R + L+ + + A++  ++   + E L   
Sbjct: 1212 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1266

Query: 4638 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4686
            +K L + +       ++  +  KI++ L  H    +E +K    K +     ++   + K
Sbjct: 1267 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1326

Query: 4687 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4746
                      KL D+  + R     +  K    + +L+E+ +   +    L AL      
Sbjct: 1327 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1365

Query: 4747 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4805
             E +  E + V   ++  +NL        K L +  S V+ + ++ R++++  + ++   
Sbjct: 1366 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1417

Query: 4806 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4865
            +  ++  L   +  + A    ++ +LE  L+ + +    ++ L EWLA  +  L     +
Sbjct: 1418 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1477

Query: 4866 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925
                  L + +   K   K++E+++  L   T +G+ +  +      T ++  ++++ + 
Sbjct: 1478 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1536

Query: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985
            +  V + A++    L      +    + ++ +  W+  A+T L + +K+   Q+ + +K 
Sbjct: 1537 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1596

Query: 4986 LIAE 4989
            L AE
Sbjct: 1597 LKAE 1600



 Score =  184 bits (467), Expect = 2e-45
 Identities = 494/2698 (18%), Positives = 1056/2698 (39%), Gaps = 384/2698 (14%)

Query: 1170 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1229
            KLK +N  L  T+          T+  EEE +  D  +++  +   K  + ++++++   
Sbjct: 333  KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 384

Query: 1230 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1289
            ++L   +     + DE    +    L+     E+   L +RW N+    ++R   L+ I 
Sbjct: 385  NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 434

Query: 1290 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1347
              LK+ R T        W+ + E    KI     ++   + + L +  +L +++E K+  
Sbjct: 435  -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 493

Query: 1348 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401
            M +     +   +T+K+  +   T      +    D+  +   K     S A    Q  +
Sbjct: 494  MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 553

Query: 1402 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1454
               T    + T+ T+    +K A + L     ++K   +++ E ++ ++    EL  W++
Sbjct: 554  TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 613

Query: 1455 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1504
                 L+  E     K G     K+K+++   E + K  +L +A ++ Q  + +  +   
Sbjct: 614  RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 673

Query: 1505 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1547
                 K   E+ N         L +++  L+   N++ F   L+QL++  T+ +  +K+ 
Sbjct: 674  NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 733

Query: 1548 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1594
                 E   +  + +  K+++  +  L  Q E   I        G    F+  D      
Sbjct: 734  PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 793

Query: 1595 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1639
             +       Q++++ELQ           Q +  A+   V+ +E   K +  +LS  D  +
Sbjct: 794  HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 851

Query: 1640 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1699
            +EQ+L E  ++  Q +L+ +QS       ++T +KE ++K  +     E   K ++  + 
Sbjct: 852  MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 901

Query: 1700 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1759
            +    K       +H Q +E+     Q    +        +   + E DV  +       
Sbjct: 902  IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 956

Query: 1760 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1819
             ++  +K   Q   ++S  Q +  +  S     +K      PE   +L+  +KEL   ++
Sbjct: 957  DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1016

Query: 1820 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1879
                +   + +      E+      D +E   W+ Q+E+E    +      + L   ++ 
Sbjct: 1017 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1076

Query: 1880 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1939
             K   E+    +  ++ +T S N V+  A   ++              ++++L+  T  +
Sbjct: 1077 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1124

Query: 1940 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1999
            + L   C  L    K L + +  + +    LL+ L+     A+K L+E        ++ +
Sbjct: 1125 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1165

Query: 2000 LEETKALQG---QISSQQVAVEKLKKTAEVLLDARGSLLPAKND-------IQKTLDDIV 2049
            L+ T+ + G   +IS    ++E L + +E   +    L     D       I + L+   
Sbjct: 1166 LKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFN 1225

Query: 2050 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-------EQGQVPL 2102
             R+ +L +    R + L+ ++  +   +  L  + + +  ++  L        +  Q+P 
Sbjct: 1226 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQ 1285

Query: 2103 NSTALQ-DIISKNIMLEQ---DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2158
             +  +Q D+ S  I LE+      G++++   +++      +  D S    L  K  +  
Sbjct: 1286 EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE 1345

Query: 2159 ARFSEASHKHKETLAKMEELKTK--------------VELFENLSE---KLQTFLETKTQ 2201
             R  E+     E    +  L+TK              V L+++LSE   +++  ++T  Q
Sbjct: 1346 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 1405

Query: 2202 ALTEVDVP-------------------GKDVTELSQYMQESTSEFLEHKKHLEVL----- 2237
             + +                       G  VTE  Q +++      + +K + VL     
Sbjct: 1406 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1465

Query: 2238 ---HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL 2294
                 L K  +  G+PS+    +       K+ ++ +  +K   E   + +  L   + L
Sbjct: 1466 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1525

Query: 2295 VKSLKS-----WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2349
            V+   S     WI  T++          AE+    L + +K  E +      I K     
Sbjct: 1526 VEDKLSLLNSNWIAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1575

Query: 2350 ISLCNLISAVTTPAKAIAAVKSGGAVLNG-----EGTATNTEEFWANKGLTSIKKDMTDI 2404
             +L +  S    P +    +K   A LN      + T        AN+G           
Sbjct: 1576 DTLLD-ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----------- 1623

Query: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2464
                +    L++ +I+ELN + + +    +   A +  L+++ +  +  Q+   P + E 
Sbjct: 1624 ----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLEPLEAEI 1678

Query: 2465 VKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2523
             +    + + F  ++ + N   V+EL  +   L +   D  +    K     + +K   L
Sbjct: 1679 QQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1738

Query: 2524 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2583
              L   R++K  E S+   Q++     L + L + E  ++ L P   D   +    +++Q
Sbjct: 1739 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQ 1797

Query: 2584 ILLQEFATRKPQYEQLTAAGQGILSRP-------------GEDPSLRGIVKEQLAAVTQK 2630
               +E    + Q E L+  G  +   P              +    R +   Q+  V ++
Sbjct: 1798 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1857

Query: 2631 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2690
                T  +      ++ + V ST Y + +  +S  L +++  L++    +   + + +Q 
Sbjct: 1858 ----TMMVMTEDMPLEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 1912

Query: 2691 ETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQLEGILKSFK 2742
            E+ + +K  +QQ   +I +  +  +  +AL        VK +   ++L  Q E + K +K
Sbjct: 1913 ESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 1970

Query: 2743 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH-PISAKLDVLESLIK 2801
            D + + +  V+  +        F Q   + + +L   +  +N  H      L  L+  I 
Sbjct: 1971 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2030

Query: 2802 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERE 2861
              +   +TL           A GE ++ ++  ++ + LQ +L ++   W    KQ+ +R+
Sbjct: 2031 QRQTVVRTLN----------ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2080

Query: 2862 NKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE---NSIAKLKSLQKEM 2918
             +L+E      +++  +     W+++  +N+  I   L+P + +     + ++K L +E+
Sbjct: 2081 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLEQVKLLVEEL 2137

Query: 2919 DQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK-------------------------- 2951
                G+++ LN T   +L    I  E     ENK                          
Sbjct: 2138 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2197

Query: 2952 ----SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-----SKRQLQCAKEQLDIH 3002
                 L +K++ + EQL+     L  +  + + + + ++E      + ++    +Q D+ 
Sbjct: 2198 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2257

Query: 3003 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD---------SKGTS 3053
            + L    +  K     Q  ++ L+ L  +     RL Q+L  +  D         +  T 
Sbjct: 2258 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2317

Query: 3054 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3113
             V L  + +  + + +S+   E  S L  ++  +  F     E+    +  D  + S   
Sbjct: 2318 TVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2375

Query: 3114 VGRDAETLQ----KQKETIKAFLKK---LEALMASNDN-ANKTCKMMLATEETSPDLVGI 3165
            +  D E +     KQK T++   ++   LE L+ +  N  NKT      T  T       
Sbjct: 2376 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD------ 2429

Query: 3166 KRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVG 3225
               +E +  Q +++ +  Q R +Q+   +K   ++    +E   +L +A    ES     
Sbjct: 2430 --RIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2487

Query: 3226 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3285
               + I +++   K   K ++   Q      N L   L++  + +  T+ +    +++NA
Sbjct: 2488 YTVDAIQKKITETKQLAK-DLRQWQTNVDVANDLALKLLRDYS-ADDTRKVHMITENINA 2545

Query: 3286 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----ANQKPPSAE-F 3339
             W++++K+V++R A L+E      +F   LE  L+W+ + E        A +K    E  
Sbjct: 2546 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2605

Query: 3340 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEA 3398
            K VK  +++ + LQ  ++        +    +KI  + E +D   +L ++L  ++ +W  
Sbjct: 2606 KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 2665

Query: 3399 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3458
            L  K+      LE  S   ++ H +L+ L  WL   +  L    PIG     +++Q   H
Sbjct: 2666 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 2725

Query: 3459 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3518
            +A + ++      +   +S  +++++  + +  + ++    + +   +  +E++ + + L
Sbjct: 2726 RAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPEERAQNVTRL 2780

Query: 3519 LQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3577
            L++         E   +   +W  ++ + L +L     +T+ L     +L++ Q +++  
Sbjct: 2781 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKG 2835

Query: 3578 K-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3634
              Q V   L++ L              QD LE +KA   +I  L  +V+   + A QL
Sbjct: 2836 SWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHVNDLARQL 2879



 Score =  104 bits (259), Expect = 3e-21
 Identities = 49/110 (44%), Positives = 73/110 (66%), Gaps = 2/110 (1%)

Query: 149 EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-QS 207
           +  ++++ LL W +Q+T  Y  +   NFTT W DG   NA+IH +RPDL D N+V   QS
Sbjct: 9   QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 68

Query: 208 NLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 256
               LEHAF +A  ++G+ +LLDPEDVD + PD+KS++ Y++SL+   P+
Sbjct: 69  ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 118



 Score = 38.9 bits (89), Expect = 0.14
 Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)

Query: 608  VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666
            +Q+LL W+     +L R    G D P+V+       +VHRA +  E   KE  I     T
Sbjct: 2691 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2745

Query: 667  APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 726
              + LT  + L  LE  Y         + R L        RA N +  L  K+ EEV  +
Sbjct: 2746 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2791

Query: 727  WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 774
            W + N        + A+  R++D+  E ++ +QE  ++L L+   A +
Sbjct: 2792 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2832


>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
          Length = 3681

 Score =  325 bits (832), Expect = 1e-87
 Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)

Query: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2238
            ++ QT LE     L   +   +   E+S  ++    +F  H+ ++            +L 
Sbjct: 338  DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 397

Query: 2239 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297
               K I +  L  D+   V E+ N L+ +++ +     EK+  +   +  +D     +K 
Sbjct: 398  LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 455

Query: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
            L  W+ +T ++   ++     E LG  LED K+  ++  +   ++++      SL +++ 
Sbjct: 456  LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 511

Query: 2358 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2415
             V   +   A AA++    VL            WAN            I    ED  +LL
Sbjct: 512  VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 550

Query: 2416 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2475
            +D        L K Q+  EE      WL +      K   T      E + + +++    
Sbjct: 551  QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 602

Query: 2476 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2531
            +A+L   KQ++ K+  LK  L   L+    T +   W        D+  Q+L + T    
Sbjct: 603  KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 662

Query: 2532 QKLEESSNNLTQFQTVEA------------------------------------------ 2549
            Q +  +  +LTQ   +E                                           
Sbjct: 663  QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 722

Query: 2550 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605
               +L  W+   E ++ S    +       +  +++V  + +E A +  + +  + + Q 
Sbjct: 723  DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 782

Query: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665
            ++ +   +      +K+    +  +W      LS+R +W++        + + L+ L   
Sbjct: 783  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 841

Query: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2724
             +  +N L       + P A+  QL+  +     +   + QI+  +      S  +KE+ 
Sbjct: 842  TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 897

Query: 2725 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2780
                +L A+         + F DV+ + E  +Q +        ++Q+     + W+   +
Sbjct: 898  QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 955

Query: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840
             + +         +++E  + + +    +L  Q           + +  K         Q
Sbjct: 956  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1015

Query: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
             +   I+  W   + Q+ E   KL+E + K  K +  ++TL  W+ +    L+E      
Sbjct: 1016 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1071

Query: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2949
            PA G++ I     L+K++ Q   +V  +     SL SV E  +++  +           E
Sbjct: 1072 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1126

Query: 2950 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3009
             K L  + D + +Q++++K  L+   +K    Q+   E    +  A+E+    D      
Sbjct: 1127 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1180

Query: 3010 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3069
            +  K    LQ   + ++  K +    K     L+ E+ +S       +  E + +E  TL
Sbjct: 1181 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1239

Query: 3070 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3129
            +      C+ L  K + +        E+ S   + +  L+ +    +  E +    E I 
Sbjct: 1240 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1299

Query: 3130 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3186
              L  LE LM  S DN N+    +LA   T   ++   I  +LE  + +  +L + A  R
Sbjct: 1300 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1357

Query: 3187 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3237
            ++ +E +I+  +E    L   +E    + K      A++ + +Q P   E + I   L  
Sbjct: 1358 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1415

Query: 3238 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3297
             ++  +E  +  QGK+     L Q  I  A K          L DV+ +++ L +K A  
Sbjct: 1416 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1463

Query: 3298 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3357
              +LQE+ +     +  L +L              +  S E +VV++Q+     L + L 
Sbjct: 1464 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1509

Query: 3358 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3417
            + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +QLE    ++
Sbjct: 1510 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1569

Query: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3477
            ++  + +  L EWL   +  L     +    S L+ ++A  KA + +I     HL     
Sbjct: 1570 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1629

Query: 3478 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3537
            +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + F ++   + 
Sbjct: 1630 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1688

Query: 3538 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595
             W+ +    L  S+        + L + ++EL  ++  +   +      + N  +  ++ 
Sbjct: 1689 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1748

Query: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655
               ++  +  +  AI  R K  T  ++   K LEQ     ++L          L+ +E E
Sbjct: 1749 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1796

Query: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715
            +   +   LK E+ +      K++ ++  N   + + L    +    +   R RE ++  
Sbjct: 1797 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1846

Query: 3716 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775
                  ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL SL + R E+
Sbjct: 1847 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1906

Query: 3776 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831
               +   +LQ +K     + R  + +  D    +        S+  ++   K       N
Sbjct: 1907 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1966

Query: 3832 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3886
            +  I  +  E  + +     L ++    TY      +   L E + +++     A ++E 
Sbjct: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2026

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3945
            L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     D  + ++ +
Sbjct: 2027 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2086

Query: 3946 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4002
              K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  K K  + E 
Sbjct: 2087 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2144

Query: 4003 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4062
            ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W+ +   + +
Sbjct: 2145 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2197

Query: 4063 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4122
            R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E  + + EE+
Sbjct: 2198 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2256

Query: 4123 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4178
               Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A  ++  ++E 
Sbjct: 2257 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2314

Query: 4179 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4234
             ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    +++ +     +
Sbjct: 2315 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2371

Query: 4235 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4278
            Q ++E +  + + L K K   +  K  ++D   E K +   L+E                
Sbjct: 2372 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2431

Query: 4279 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4316
                         ++ ++    KLE   +L+    AL  F  A  EL  WL+  + ++  
Sbjct: 2432 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2491

Query: 4317 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4375
            Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA  +  +++E
Sbjct: 2492 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2551

Query: 4376 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
             +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + K      + 
Sbjct: 2552 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2611

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4495
             ++++    ++       +           ++L          +     N+   W S+  
Sbjct: 2612 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2671

Query: 4496 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4549
            +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+    V   +
Sbjct: 2672 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2731

Query: 4550 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4608
             + +    E+ +H +    LD+     L+      D VL++  L ++  +W ++ ++ + 
Sbjct: 2732 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2791

Query: 4609 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4668
                L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q   H+ F++ L
Sbjct: 2792 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2851

Query: 4669 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4709
              K  V  +T  T                    R L  +    +    L     E+  +W
Sbjct: 2852 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2911

Query: 4710 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4767
            + +   S + Q K++E L    +  +A   L   L + E      QPV GD  ID + + 
Sbjct: 2912 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2970

Query: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
            ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+ +       
Sbjct: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3023

Query: 4828 QTRLEAALRQAEEFH 4842
            Q  +E  +RQ  E H
Sbjct: 3024 QVAVEDRVRQLHEAH 3038



 Score =  316 bits (809), Expect = 5e-85
 Identities = 548/2809 (19%), Positives = 1128/2809 (40%), Gaps = 353/2809 (12%)

Query: 1839 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1898
            L+++     E   WL  +E  L+     ++D+  +  +    + +  D+ +H+G +  I 
Sbjct: 337  LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 396

Query: 1899 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1958
              G++++   K     +           EVQ +++    R+  L        +NL  ++ 
Sbjct: 397  QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446

Query: 1959 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2018
              Q+ +     L   L   E    K   EP+  D ++L+RQ+++ K LQ  +  +QV V 
Sbjct: 447  DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 504

Query: 2019 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2077
             L     V+ ++ G    A  + Q K L D   R+ ++ +   +R   LQ  L +   + 
Sbjct: 505  SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 561

Query: 2078 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2131
            +       W+   E ++ +     +++T  +D       + K  +L+ D+  ++ S+  +
Sbjct: 562  EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 616

Query: 2132 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2190
                +  + T  + S     +A + + +  +     K +++ A++ +  T  +   +L++
Sbjct: 617  YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQ 674

Query: 2191 KLQTFLETKTQALTEVDVPGKDVTEL-----SQYMQESTSEFLEHKKHLEV----LHSLL 2241
               T +ET T   T   +  K   E       Q  ++ T +  E +K L+V    LHS +
Sbjct: 675  T--TVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-EIRKRLDVDITELHSWI 731

Query: 2242 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2278
               S   L S +  +  K  N S              +KF++++D  +  +         
Sbjct: 732  TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 790

Query: 2279 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2330
                +++    EQL++    F  L+    +W++     +         E +  + E+  K
Sbjct: 791  GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 850

Query: 2331 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2389
            +Q      TP       S + +C + ++ ++     I  +K     L  +G         
Sbjct: 851  IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 897

Query: 2390 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2447
              +G   +  D    ++ ++ +   ++ +  EL T    L   + QE  SA+  W+Q+ +
Sbjct: 898  --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 954

Query: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507
            +T     Q    TD E ++ ++ + ++ ++ L++  + +  L   + E+ ++ P +  + 
Sbjct: 955  ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1012

Query: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567
            +++    EI+ +W++L+   ++  QKLEE  N L + Q     LK+W+ E ++ +    P
Sbjct: 1013 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1072

Query: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2627
               D  +L  Q +Q ++L+ +  T +P    +   GQ I +    +P     ++ +L  +
Sbjct: 1073 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1130

Query: 2628 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2687
              +WD +  Q+  R + +   + K+   Q  L  + + ++  + +          PD + 
Sbjct: 1131 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1190

Query: 2688 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2745
            + +E  ++ K+E QQ++ ++K+   L E +++++ +    A+  L ++LE +  +++ + 
Sbjct: 1191 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1247

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2798
             +     + L+   A  H+          WL+       T +     +  IS  LD LE+
Sbjct: 1248 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1307

Query: 2799 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2842
            L++  +D        ++TLT    M E    E E    + +   + A++ Q         
Sbjct: 1308 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1367

Query: 2843 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2874
                   L+ I+ +    +KQ+              +   K++        SLE+  K+ 
Sbjct: 1368 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1427

Query: 2875 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2927
              KE  + +   ID  Q  L+++  KF L   PA  E  + + K +  E+  H   +E  
Sbjct: 1428 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487

Query: 2928 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 2975
                      LN+  N   S+ E+  EV  V    + ++QK     +Q  + K   E +T
Sbjct: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1542

Query: 2976 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3031
                 + E+     E K+QL+ C K    +   +           M  T++ +++ +   
Sbjct: 1543 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1602

Query: 3032 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3087
            +D      K   +++  +    K  ++V   ++T+  +  TL   V++K S L +    +
Sbjct: 1603 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1659

Query: 3088 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3143
                  + N + E       FD  +D +      A+TL  + E  K   K+ + L     
Sbjct: 1660 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1718

Query: 3144 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3196
              N     + +T + + +L+  + D   + +  Q ++L  R  A   +++       +K 
Sbjct: 1719 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1778

Query: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
            LE+F S +++   LL+  E   E Q  V ++ E  N+ +N          E  +G  +++
Sbjct: 1779 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1823

Query: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
               G  L Q        + ++     +  +   L    +QR  +  E      +++   +
Sbjct: 1824 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1883

Query: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3373
             LL  + D E+ +A+   P  E K+        K + R L  +K  +  ++R+ E +   
Sbjct: 1884 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1935

Query: 3374 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3417
              A   EP  ++++ K+   ++S++     LN A+            T +  LE IS V 
Sbjct: 1936 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1993

Query: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3474
              +   +  +++ L  +E+ L   +        L +Q    K ++D +   +  +   H 
Sbjct: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2053

Query: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3534
              +          R       S+LDF    + ++ +    R     +++   + F  D  
Sbjct: 2054 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2110

Query: 3535 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3594
                WL E    L K  + +      +K    L+ LQ+ I  R+  V      G E+++Q
Sbjct: 2111 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2168

Query: 3595 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3654
            ++  +  I+Q+KL ++  R++++ K  +D  K LE+   +         E   WL++ + 
Sbjct: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2227

Query: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3712
             + S   +  K ++  +   + K L +E    + +L  LNE    +L   P    E   L
Sbjct: 2228 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2287

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3765
            E  + + N ++  VS  + +K  EI+A I        + +  ++  +  L W++    +L
Sbjct: 2288 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2347

Query: 3766 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825
                     Q        VQ+T      +  D+ + L K  H       +   Q +K+KL
Sbjct: 2348 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2399

Query: 3826 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3871
            + +   +  + ++  E R  Q + A              +LV Q   T E     L    
Sbjct: 2400 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2459

Query: 3872 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3914
            S++ ++PA A              L  + ++ Q+    +   + E+I + K  +  + + 
Sbjct: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519

Query: 3915 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3962
             PQL EL           S  E  +I  ++       + +++E ++ R   L+E +  ST
Sbjct: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579

Query: 3963 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4019
            Q+    ++ +Q+L      +E  ++ P     V+ I+++I+E K ++ D+ + Q   +  
Sbjct: 2580 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2636

Query: 4020 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4079
                 +++ R    D       + + ++     W +IH  V EREA L +   L ++F  
Sbjct: 2637 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2692

Query: 4080 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4135
            D    +  + + +     L+D      +++  +   E +++  D LQ E+    D+  NL
Sbjct: 2693 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2751

Query: 4136 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4191
                   L +  G  D  ++++ +D +N  W  L K   +    LE +     +    LQ
Sbjct: 2752 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2811

Query: 4192 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4233
             +  W+ +   +L+  +PIG D   V++Q +  + FK E                    +
Sbjct: 2812 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2871

Query: 4234 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4292
            Q +E +E+L  +   L  +   ++    ++    E+   W+ L     + Q K++  L  
Sbjct: 2872 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2931

Query: 4293 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
            L + Q A DEL   L   E +    +PVG     +++  L K   L+ ++   +  V  V
Sbjct: 2932 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2991

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4400
            N     L          NL + LE LN RW+ +    E R +QL  A R
Sbjct: 2992 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3039



 Score =  313 bits (803), Expect = 2e-84
 Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)

Query: 2373 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2432
            G+ L G G  +  EE       T +++ M  ++  +E L +   +K + L+  L  LQ  
Sbjct: 399  GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 450

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2492
             ++   +  WL K  +   K ++ P   D E +K QV+Q+K  + +L+Q   +V  L   
Sbjct: 451  -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 509

Query: 2493 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2552
            +  + E + D   A   +Q L  +  +W  + + T DR   L++      +    +    
Sbjct: 510  VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 568

Query: 2553 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2611
             WL EKE  V+ +      D N + +  Q++ +L  +   +K    +L +  Q +LS   
Sbjct: 569  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 627

Query: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2654
            ++ S+    +  L    + WD+L  +L      I QA+  +                 T+
Sbjct: 628  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687

Query: 2655 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2696
             Q L++   ++L            +D+++   L V         T  +A+ Q  E A   
Sbjct: 688  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 747

Query: 2697 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2736
            K+            I++EK +         + AQAL E + +  V  + +K + S QL  
Sbjct: 748  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 806

Query: 2737 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2795
                F  +  +  N +++  +  A  +Q QQ+ +     + T  E   K  P + ++   
Sbjct: 807  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 861

Query: 2796 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2855
            ++S +K  KD    L+      E+   + +++ LK +G     L         ++     
Sbjct: 862  IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 919

Query: 2856 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2912
             V+ RE +L+   +    ++Y+E +  +  W+ + +  L   +  +   E  E  + +L+
Sbjct: 920  DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 979

Query: 2913 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 2972
            +LQ  + +    +  L+ T      V E+ K+  ++ ++    + + +  +       L 
Sbjct: 980  ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1033

Query: 2973 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3024
               QK +E     ++ +  +Q  K+   ++D+       +LG      K L   +     
Sbjct: 1034 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1093

Query: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3084
            +Q ++  ++      Q +  EA + +  S +  +++ +  +   + QQV  +   L+  L
Sbjct: 1094 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1152

Query: 3085 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3144
            +     Q  + EM     + ++E        +  + LQK  E +K          A  + 
Sbjct: 1153 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1203

Query: 3145 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3196
              K  K+ L TE  +  +          +K++LE L+     L  R   + + +E     
Sbjct: 1204 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1263

Query: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
              E  S L++ +  L + E   ++   +    E I++ L+  +   +      +     +
Sbjct: 1264 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1319

Query: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
              L Q L          + +  +L+  N+RW+ L+++  +R   L++++      Q A E
Sbjct: 1320 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1370

Query: 3317 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3373
            +  S  +  E L    K  +A    KV  AQ+ QE + +Q  L   + ++E +K+  +  
Sbjct: 1371 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1430

Query: 3374 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3432
                    ++ +  K+L  +  ++      A    R  E   +        L+ +   L 
Sbjct: 1431 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1482

Query: 3433 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3492
             +E + V  E + +Q   L   +  +K+L +        +   +  G+ +      E+  
Sbjct: 1483 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1535

Query: 3493 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3552
             +  ++   ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S 
Sbjct: 1536 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1595

Query: 3553 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
             +     L  + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + +
Sbjct: 1596 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1654

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
             +  +T  + +    L +  +         + +  W+  ++ + L  E++  K ++    
Sbjct: 1655 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1712

Query: 3673 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732
                K LK E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  
Sbjct: 1713 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1767

Query: 3733 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3792
            K  +    +   +QF+              +KL+   +  ++Q     +    K    + 
Sbjct: 1768 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1815

Query: 3793 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3851
              ++  + +L++ G  +    ++E K + +K K   +   ++ +  + S+R  +      
Sbjct: 1816 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1873

Query: 3852 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3911
               Q+    ++L   L + +  ++ LP P            + R+++E+  E +   +++
Sbjct: 1874 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1922

Query: 3912 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3967
            N    Q   LS  G   +++   +     + +I+      ++   A    + + T     
Sbjct: 1923 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1982

Query: 3968 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4027
             D  LE        L +   +S  + ++++ ++     + D E L    E+LK   + + 
Sbjct: 1983 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2042

Query: 4028 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4074
              SG  D   S K              +Q+ L Q+ F WE ++ + ++R+ +    +E  
Sbjct: 2043 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2102

Query: 4075 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4131
             +F  D       + + + F+R  + P        +  E A+    ++E  DG+ +   +
Sbjct: 2103 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2154

Query: 4132 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4188
            V  L   G E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q 
Sbjct: 2155 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2214

Query: 4189 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4248
             L     W++ A   +AS+       + +K+++E++K    E   +Q  +++LN     +
Sbjct: 2215 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2273

Query: 4249 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4303
            L       EE DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L  
Sbjct: 2274 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2331

Query: 4304 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4356
                 L WL+     L    Q    G     E E+A        V A Q  VE +   G 
Sbjct: 2332 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2383

Query: 4357 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4384
             L +     +   ++ KLE L+  W+ V                                
Sbjct: 2384 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2441

Query: 4385 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
                  ++T   K ++  +L         F+    +L  WL+  ++ + + + + G  E 
Sbjct: 2442 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2501

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4494
              E +          E +    + L+   Q +  +   + A T I   I  ++ +W+ V+
Sbjct: 2502 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2561

Query: 4495 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4554
              L  R+ +L E L  + ++  + ++    L QA   L         +D +  +I E K 
Sbjct: 2562 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2621

Query: 4555 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4614
             A ++   +  +   +     L       D   +  +  ++ + W  + +R+ ER  +L+
Sbjct: 2622 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2681

Query: 4615 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4668
            +  +  +QF     K + WL E+E + +       +  +  D   +K  + Q ++ Q  +
Sbjct: 2682 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2741

Query: 4669 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728
             A   VY   +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +  
Sbjct: 2742 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2801

Query: 4729 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4782
               +   +LQ L+ WL   + +L+   P+ GD   V    D H+AF++EL  +       
Sbjct: 2802 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2861

Query: 4783 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
                           ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   
Sbjct: 2862 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2921

Query: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887
            Q +++  L + +E       L   L +AE        + D       LID  ++ ++K++
Sbjct: 2922 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2975

Query: 4888 EKRAEL 4893
              R E+
Sbjct: 2976 ALRGEI 2981



 Score =  308 bits (789), Expect = 1e-82
 Identities = 502/2696 (18%), Positives = 1071/2696 (39%), Gaps = 346/2696 (12%)

Query: 2650 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2709
            V   +YQ+ L  +   L   ++ L +   +S   + +  Q  T +    ++   + ++  
Sbjct: 335  VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 394

Query: 2710 AQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQM 2768
               L   L    K  E  + E+  Q+  +L S  +  + A    Q          Q Q++
Sbjct: 395  ILQLGSKLIGTGKLSEDEETEVQEQMN-LLNSRWECLRVASMEKQSNLHRVLMDLQNQKL 453

Query: 2769 SRDFQAWLDTKKEEQNKS---HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
             ++   WL TK EE+ +     P+   L+ L+  ++ HK   + L  Q  +   ++    
Sbjct: 454  -KELNDWL-TKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLE-QEQVRVNSLTHMV 510

Query: 2826 NLLLKTQGSEK-AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2884
             ++ ++ G    AAL+ QL  +   W    +  ++R   L++ L K  +  E+      W
Sbjct: 511  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570

Query: 2885 IDKCQNNLEEIKFC--LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2942
            + + ++ + +I      D  E  +S+ KL  L+ ++++    +  L +    LLS   + 
Sbjct: 571  LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST--LK 628

Query: 2943 KEVVTDENKS-----------LIQKVDMVTEQLH----------SKKFCLENMTQKFKEF 2981
             + VT + ++           L+QK++  T Q+           ++   +E +T      
Sbjct: 629  NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 688

Query: 2982 QEVSK-----------ESKRQLQCAKE---QLDIHDSLGSQAYSNKYLTMLQT------- 3020
            Q + K           + KRQ+    E   +LD+ D     ++  +   +LQ+       
Sbjct: 689  QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV-DITELHSWITRSEAVLQSPEFAIFR 747

Query: 3021 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQ--------VETIAQEHSTLSQQ 3072
            ++ +   LK +V+  +R   +   +  D+  ++  L++         ++I Q    L+ +
Sbjct: 748  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 807

Query: 3073 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3132
              E C  L  +L  +  +QN I   ++Q  + +    +     +   T   +   IK+ L
Sbjct: 808  WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 866

Query: 3133 K----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3188
            K    ++  L        +     +A +E     + +  D  A +    ++    QARE+
Sbjct: 867  KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 926

Query: 3189 QVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3246
            +++     L    +   +      +Q++E           + E + Q+L   +  Q    
Sbjct: 927  ELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSS-- 984

Query: 3247 EPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3304
              LQ +Q  + +L   + + + K+ S  ++  + + +++  RWK L+ ++ +   +L+E 
Sbjct: 985  --LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 1042

Query: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3364
            +    + Q+ +++L  WM + +  +  + P   + +++K Q+++ +LL   +   + ++ 
Sbjct: 1043 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLN 1102

Query: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3424
             +   G+KI   AEP    ++  +L  L+++W+ +  +   R   L+G         + L
Sbjct: 1103 SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDL 1162

Query: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3484
              ++EW+T  E+  +  +       +L++ + + K  +++       +        S+  
Sbjct: 1163 SEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1222

Query: 3485 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKIFGEDEVELMNWLNEV 3543
             +    ++ ++ +L+     Y  +  + + + + L++   C  ++    E +   WLNEV
Sbjct: 1223 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE-KANKWLNEV 1281

Query: 3544 HDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL- 3601
              KL        +TE +     E+  VL     L + + D    N + +L QT  D  + 
Sbjct: 1282 EFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--NQIRILAQTLTDGGVM 1332

Query: 3602 --IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH-STH--EELCTWLDK----- 3651
              +I ++LE   +R++++ + +    K LEQ++Q A+    S H  +E  T++DK     
Sbjct: 1333 DELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1392

Query: 3652 ----------------VEVELLSYETQVLK------GEEASQAQM--------------- 3674
                            ++ +L S+E  + +      G+EA+Q  +               
Sbjct: 1393 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM 1452

Query: 3675 ------RPKELKKEAKNNKALLD-------------------------------SLNEVS 3697
                  +P   ++  + +K +LD                               SL+EV 
Sbjct: 1453 KFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 1512

Query: 3698 SALLELVPWRAREGLEKMVAED----NER-------YRLVSDTITQKVEEIDAAILRSQQ 3746
            S + E+V    R+ ++K   E+    +ER       Y  +   +T++ ++++  +  S++
Sbjct: 1513 SEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1571

Query: 3747 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806
              +  +    W+  T+ +L     +        +++   K    EI + K  +  + + G
Sbjct: 1572 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1631

Query: 3807 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866
              + T   ++E   ++ KL  +  N+  +     E    L   Q  +  F +  + +  W
Sbjct: 1632 EALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1690

Query: 3867 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3926
            + +  +++        E E  + QQ+E   L+ L AE      K++ T  Q   L    G
Sbjct: 1691 IIQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRG 1742

Query: 3927 FS----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 3982
                  ++ +    +  ++ I   +K    ++   + +  QF+  I ++LE LE  +++ 
Sbjct: 1743 DHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ- 1799

Query: 3983 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042
                 ++ + E   + ++E+   +V         + L QRG+ +  R     K    K  
Sbjct: 1800 ----GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIK 1846

Query: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4102
            Q  L         +  L  +R  K L++     ++      L+  + D +  +  L +P 
Sbjct: 1847 QQLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1903

Query: 4103 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4162
             D   +K+     +  +EE++ ++ + +    L  +  A   EP +  + K   E+ S +
Sbjct: 1904 -DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKF 1959

Query: 4163 DSLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSP 4209
                +    +I  + EE M    +            Y   +  V   +      L +   
Sbjct: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2019

Query: 4210 IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4269
               D E + +Q E LK  K    Q    ++ ++ +    L+  T   ++  +Q+ L +L 
Sbjct: 2020 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLD 2078

Query: 4270 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIE 4328
              W+ + +   +RQ + + ++    +F + +     WLT  E  L + Q P   +    +
Sbjct: 2079 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2138

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4388
              L +   LQ+ +   Q+ V  +N  G ++I+ S+  +AS LQ KL  LN RWQ V ++ 
Sbjct: 2139 WYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2195

Query: 4389 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVC 4447
              RK++L+        F  ++ +   WL + +   +AS PL  G  +  KE+L     + 
Sbjct: 2196 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLV 2253

Query: 4448 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKL 4504
                 ++   K L + G  +L   P S E   D+  N LK+   +W  V   L E++ ++
Sbjct: 2254 EELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEI 2312

Query: 4505 EEALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFAN 4557
            E  +    +    L+D        + WL+     L + ++P+       F + E ++   
Sbjct: 2313 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI--- 2366

Query: 4558 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------ 4611
             V + +  + E+   G HL  + +K     +K  L  + S W K V RL++  R      
Sbjct: 2367 AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDL 2423

Query: 4612 ------------------------------------SLDDARKRAKQFHEAWSKLMEWLE 4635
                                                SL         F+ AW++L +WL 
Sbjct: 2424 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS 2483

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4695
              ++ + S+  +  D + I   + + K   + L  +    +      ++LK KTS  +  
Sbjct: 2484 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEAR 2543

Query: 4696 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4755
              + D +  ++++WD +      R+ +L E L  S Q+ +A +     L +   +L   +
Sbjct: 2544 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 2603

Query: 4756 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELS 4814
                 +D +   I   K   K+L +  ++V      A +L+   S DD+  V +  + ++
Sbjct: 2604 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 2663

Query: 4815 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT 4874
              W ++      ++  LE   R  ++F   +   L WL EAE T     VL D     R 
Sbjct: 2664 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERL 2720

Query: 4875 LIDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRA 4924
            L D    KE MK+ ++ + E+   T +   +         ++   D    ++  +  +  
Sbjct: 2721 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2780

Query: 4925 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK 4984
            ++ E+   +   +  L ++          L+ LL WLQ  +  L+ +    I  +   V+
Sbjct: 2781 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQ 2838

Query: 4985 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLY 5044
                 H+ F  E+  K+P +    +T +            I + ++   G ++     LY
Sbjct: 2839 KQNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LY 2881

Query: 5045 PSGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5092
                +   E +   V  L+ K        W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 2882 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2937



 Score =  295 bits (755), Expect = 8e-79
 Identities = 474/2585 (18%), Positives = 1053/2585 (40%), Gaps = 294/2585 (11%)

Query: 2534 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2593
            L ES  NL ++QT   ++  WL+  E  +   G +S D  ++  Q    +  + +    +
Sbjct: 330  LMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQ 389

Query: 2594 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2653
             +   +   G  ++            V+EQ+  +  +W+ L     ++   + + ++   
Sbjct: 390  GRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 449

Query: 2654 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA--MNQQLETAQKMKQEIQQEKKQIK--V 2709
              +  L+ L+D L+  + +          PD   + +Q++  + ++++++QE+ ++    
Sbjct: 450  NQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 507

Query: 2710 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2769
               +  D S+    ++  A L  QL+ +   + ++ +  E+    LQ       +  +  
Sbjct: 508  HMVVVVDESS---GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 564

Query: 2770 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2829
              F AWL  K++  NK H             KD  +   +L                   
Sbjct: 565  CLFSAWLSEKEDAVNKIHTTG---------FKDQNEMLSSL------------------- 596

Query: 2830 KTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID--- 2886
                 + A L+  L           KQ   +   LK+ L   LK K   +    W+D   
Sbjct: 597  ----QKLAVLKADLEK--------KKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 644

Query: 2887 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2946
            +C +NL +    L+ +  + S A + + Q  + Q   M  +   T    + V    +E+ 
Sbjct: 645  RCWDNLVQ---KLEKSTAQISQA-VTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 700

Query: 2947 TDE---------NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE 2997
                        +  + +++D+   +LHS     E + Q   EF    KE        KE
Sbjct: 701  PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS-PEFAIFRKEG--NFSDLKE 757

Query: 2998 QLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3057
            +++  +   ++ +       LQ   +S QAL               VE   ++G     +
Sbjct: 758  KVNAIEREKAEKFRK-----LQDASRSAQAL---------------VEQMVNEG-----V 792

Query: 3058 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3117
              ++I Q    L+ +  E C  L  +L  +  +QN I   ++Q  + +    +     + 
Sbjct: 793  NADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKI 851

Query: 3118 AETLQKQKETIKAFLK----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3173
              T   +   IK+ LK    ++  L        +     +A +E     + +  D  A +
Sbjct: 852  QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 911

Query: 3174 KQCNKLLDRAQAREEQVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3231
                ++    QARE++++     L    +   +      +Q++E           + E +
Sbjct: 912  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971

Query: 3232 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKT 3289
             Q+L   +  Q      LQ +Q  + +L   + + + K+ S  ++  + + +++  RWK 
Sbjct: 972  EQRLGELQALQSS----LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1027

Query: 3290 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3349
            L+ ++ +   +L+E +    + Q+ +++L  WM + +  +  + P   + +++K Q+++ 
Sbjct: 1028 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1087

Query: 3350 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ 3409
            +LL   +   + ++  +   G+KI   AEP    ++  +L  L+++W+ +  +   R   
Sbjct: 1088 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147

Query: 3410 LEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN 3469
            L+G         + L  ++EW+T  E+  +  +       +L++ + + K  +++     
Sbjct: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207

Query: 3470 KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKI 3528
              +        S+   +    ++ ++ +L+     Y  +  + + + + L++   C  ++
Sbjct: 1208 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1267

Query: 3529 FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLN 3587
                E +   WLNEV  KL        +TE +     E+  VL     L + + D    N
Sbjct: 1268 LSYLE-KANKWLNEVEFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--N 1317

Query: 3588 GLELLKQTTGDEVL---IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA----RRLHS 3640
             + +L QT  D  +   +I ++LE   +R++++ + +    K LEQ++Q A    + LH 
Sbjct: 1318 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1377

Query: 3641 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSAL 3700
              E L T++DK   +L +Y   +    +A+Q     ++++ +  +++  L+ + + +   
Sbjct: 1378 IQESL-TFIDK---QLAAY---IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN--- 1427

Query: 3701 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ---FDQAADAELSW 3757
                  + +E  ++++++         D   +K++++       Q+   F+Q        
Sbjct: 1428 ------QGKEAAQRVLSQ--------IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1473

Query: 3758 ITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEE 3817
            + E +  L +L    +EQ+   +QL         +   K  ++ ++K+G +I+     E 
Sbjct: 1474 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1533

Query: 3818 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3877
             + + +++  +  +Y+ +    +ER  QLE+   L  +  +    L  WL  T   +++ 
Sbjct: 1534 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1593

Query: 3878 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3937
             A       L  +    +  ++ I + K H+  + + G  L  +   +   +++K     
Sbjct: 1594 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL---- 1649

Query: 3938 TLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE 3997
            +L +     V  RA   +E ++   ++   ++   ++++ I + + Q  ++  E EK K 
Sbjct: 1650 SLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1706

Query: 3998 QISEN--KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4055
            Q  E+  K +  ++  ++P  ++ + +   ++A  G    D   K V+ ++ ++   +  
Sbjct: 1707 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELNHRFAA 1762

Query: 4056 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4115
            I   ++  +A +   ++  E+F  D   L+  ++       +L++   +  + +  +   
Sbjct: 1763 ISHRIKTGKASI--PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 1820

Query: 4116 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4175
            + + +  D LQ+ +               E  +  +K     L +  ++L      R  K
Sbjct: 1821 KELLQRGDNLQQRI-------------TDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1867

Query: 4176 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ 4235
              E      QY+     +   +D    KLAS+ P   D   +K+   EL++ K       
Sbjct: 1868 ALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQKKKE------ 1920

Query: 4236 IEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN-------RQHKL-E 4287
             E+  +  QAE L    +E+     V+   ++L   W  +E +          + H + E
Sbjct: 1921 -ELNAVRRQAEGL----SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE 1975

Query: 4288 GALLALG-----QFQHALDELLAWLTHTEGLLSEQKPVGGDP----KAIEIELAKHHVLQ 4338
              ++ +      +  +     L  +TH    L E + +   P    K  E    +   L+
Sbjct: 1976 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 2035

Query: 4339 N--DVLAHQS-TVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4395
            N  D L   S  ++ ++      ++S+   E   LQ  L  L+ +W+ V +  + R+ + 
Sbjct: 2036 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 2095

Query: 4396 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET---AKEQLNVHMEVCAAFEA 4452
            D ++ + + FH +I+   QWLT+ E+ L  ++    +PE    AK +  +  E+      
Sbjct: 2096 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYL-KELQDGIGQ 2150

Query: 4453 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4512
            ++   ++L   G++++ +  K+  + + + + +L  +W+ V  +L++RK +LEE  N+  
Sbjct: 2151 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2210

Query: 4513 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4572
            EF   L +F+ WL +A+   ++   P      +  ++++ K+   E+   +  + +L++T
Sbjct: 2211 EFQRDLNEFVLWLEEADNIASIPLEPGK-EQQLKEKLEQVKLLVEELPLRQGILKQLNET 2269

Query: 4573 G----THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERG-------RSLDDARKRAK 4621
            G           ++QD   ++N L     +W KV + L E+        + L    K+ +
Sbjct: 2270 GGPVLVSAPISPEEQD--KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2327

Query: 4622 QFHEAWSKLMEWLEESEKSLDSELEIANDP------DKIKTQL---AQHKEFQKSLGAKH 4672
               E  + L+ WL      + ++LEI N P      D  +T++   A+  + ++ L    
Sbjct: 2328 DLEEQLNHLLLWL----SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2383

Query: 4673 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD------TICGKS---------- 4716
             +Y     T    ++   L+ +   ++ +L ELR K        T  G S          
Sbjct: 2384 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 2443

Query: 4717 -----------VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4765
                       +E  + L   +     F  A   L DWL  ++  +   + + GD++ + 
Sbjct: 2444 PVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDIN 2503

Query: 4766 NLIDNHKAFQKELGKRTSSVQALKRSARELIE--GSRDDSSWVKVQMQELSTRWETVCAL 4823
             +I   KA  ++L +R   ++ L  +A+ L     +++  + +  +++ +  +W+ V   
Sbjct: 2504 EMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEH 2563

Query: 4824 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4883
              +++ +L   L+ + ++        + L +A   L      P   DA++  I + K+  
Sbjct: 2564 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2623

Query: 4884 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4943
            K L + +  ++ A  +   +L     D    + H IT      E + A  +   +R++  
Sbjct: 2624 KDLRQWQTNVDVANDLALKLLRDYSADDTRKV-HMIT------ENINASWRSIHKRVSER 2676

Query: 4944 LAGLIAKQEL-------LEALLAWLQWAETT---LTDKD-KEVIPQEIEEVKALIAEHQT 4992
             A L     L       LE  LAWL  AETT   L D   KE + ++ + VK L+ + Q 
Sbjct: 2677 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 2736

Query: 4993 FMEEM 4997
               E+
Sbjct: 2737 LQGEI 2741



 Score =  277 bits (708), Expect = 2e-73
 Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)

Query: 2077 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2136
            Q  L+E+L W+ + E +L+ QG++  +   ++D    +     D+   Q  +  + +   
Sbjct: 341  QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 400

Query: 2137 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2194
            K + T   S    + +Q +M  L++R+        E  + +   +  ++L     ++L  
Sbjct: 401  KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 458

Query: 2195 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2248
            +L TKT+  T   E +  G D+ +L + +Q+       HK   + LE     +  ++   
Sbjct: 459  WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 510

Query: 2249 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2301
            +  D++     T  L ++ K + D      +  ++     Q+ L  +Q L +      +W
Sbjct: 511  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570

Query: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2347
            + E    V  +  + G +D  + L   +KL               + +SLK   +  + N
Sbjct: 571  LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 629

Query: 2348 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397
              ++      L N      + V    K+ A +    AV   + + T T        +T+ 
Sbjct: 630  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 686

Query: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457
             ++   + H  E+L      K  ++       ++   + + +  W+ +         Q+P
Sbjct: 687  -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 741

Query: 2458 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2513
              A    E   + +++   + E E  +   K+Q+       L+E+  +    A   KQ  
Sbjct: 742  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801

Query: 2514 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2573
             +++S+W E  QL  +R   LE   NN+  F     QL+Q     E  + +      +P 
Sbjct: 802  EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 860

Query: 2574 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2633
             + +Q +  +  +   +  +PQ E+L       L   G+ P     +     A T  +  
Sbjct: 861  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 916

Query: 2634 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2691
            +   +  R   +      +   +YQ  + ++   +   + KLS      T  + M Q+L 
Sbjct: 917  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 976

Query: 2692 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2751
              Q ++  +Q+++  +       +++S     E +  +   + E I   +K +  +   H
Sbjct: 977  ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1035

Query: 2752 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2811
             Q L+       + Q   +  + W+        +  P     ++L+  +K  +     + 
Sbjct: 1036 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1095

Query: 2812 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2871
                        G+ +  + +    + L+ +L  + T WD   +QV  R+  LK  LEK 
Sbjct: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155

Query: 2872 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2930
            +  ++ +  +  W+ + +    E  F    P E + ++ ++K  ++E  Q    V+LL  
Sbjct: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1215

Query: 2931 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 2989
            + NS+++    + +E +  E ++L      +  +L+ K   LE +   + E     +++ 
Sbjct: 1216 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1275

Query: 2990 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3048
            + L   + +L   +++ G     ++ L  L+   +  +   +Q+ +   LAQ L      
Sbjct: 1276 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1327

Query: 3049 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3106
              G  D L+  ++ET       L ++   +   LE  +Q     + ++  +       D 
Sbjct: 1328 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387

Query: 3107 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3166
            +L +      DA  + ++ + I++ L   E                ++ EE      G +
Sbjct: 1388 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1431

Query: 3167 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3223
                 LS+     +D AQ + + V    +  ++   F  +L+E  ++L + + H  +   
Sbjct: 1432 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1486

Query: 3224 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3283
              +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +
Sbjct: 1487 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1544

Query: 3284 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3343
               +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + 
Sbjct: 1545 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1604

Query: 3344 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3403
            +++   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++A
Sbjct: 1605 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1663

Query: 3404 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3463
            E     L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +
Sbjct: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1721

Query: 3464 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3515
            DI              Q+  ++++R D  + +V+ ++      F+ + + I+  + S   
Sbjct: 1722 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1776

Query: 3516 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3569
             EL Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+
Sbjct: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1834

Query: 3570 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
              E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K
Sbjct: 1835 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1894

Query: 3627 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3683
             L    +    R++     EL     K E+  +  + + L  + A+ A +    +L K  
Sbjct: 1895 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1952

Query: 3684 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3742
            +  ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L
Sbjct: 1953 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2008

Query: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3802
              +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +
Sbjct: 2009 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2068

Query: 3803 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3862
                 K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ       
Sbjct: 2069 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2114

Query: 3863 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3922
               WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S
Sbjct: 2115 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2169

Query: 3923 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981
                 SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + 
Sbjct: 2170 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2228

Query: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041
            +   P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     
Sbjct: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2286

Query: 4042 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4092
            +++KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   +
Sbjct: 2287 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2344

Query: 4093 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4152
            + +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK
Sbjct: 2345 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2396

Query: 4153 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4177
            + +++L+S W ++N+  ++                                    I KLE
Sbjct: 2397 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2456

Query: 4178 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4231
                    + A   +      + DW+ +    + S   +  DLE + + I + K    + 
Sbjct: 2457 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2516

Query: 4232 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4291
             Q++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L 
Sbjct: 2517 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2576

Query: 4292 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
               Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  
Sbjct: 2577 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2636

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
            N     L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E 
Sbjct: 2637 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2696

Query: 4412 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4465
               WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q
Sbjct: 2697 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2756

Query: 4466 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4524
            ++L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + W
Sbjct: 2757 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2816

Query: 4525 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4584
            L   +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q 
Sbjct: 2817 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2873

Query: 4585 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4635
            +  ++ L      +  + R + V + L          RK+A++ +  W KL     +W  
Sbjct: 2874 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2923

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQ 4660
            + +++L+   E+    D++  +L Q
Sbjct: 2924 KIDETLERLQELQEATDELDLKLRQ 2948



 Score =  226 bits (576), Expect = 5e-58
 Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)

Query: 3299 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3358
            + L E+ ++  R+Q ALE +LSW++  E+ +  Q   S + +VVK Q    +     L  
Sbjct: 328  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 387

Query: 3359 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3416
             +  V  I + G K+  T + +  ++ ++ +Q++LL+SRWE L   +  +   L  + + 
Sbjct: 388  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 447

Query: 3417 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3470
             Q  ++ L+ LN+WLT  E+R   +  EP+G     L+ Q+ QHK L++D+    +  N 
Sbjct: 448  LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 505

Query: 3471 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3530
              H  V + +S    S       ++ +L      +  I   +  R  LLQ  L   +   
Sbjct: 506  LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561

Query: 3531 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3590
            E++     WL+E  D ++K+      T G   Q   L  LQ+  +L+           LE
Sbjct: 562  EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 607

Query: 3591 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3650
              KQ+ G    + QD L  +K +                          S  ++   WLD
Sbjct: 608  KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 641

Query: 3651 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3710
                    ++  V K E+++    +     + +     +++++  V++    LV   A+E
Sbjct: 642  NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 697

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
             L        ++ ++  D+  +K  ++D   L             SWIT +E  L S   
Sbjct: 698  ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 743

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3826
                ++   + L+ +K   +E  + +    + D  +S   ++     E     S+K+  +
Sbjct: 744  AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 802

Query: 3827 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3886
            ++   +   CQ+ SER   LE   +++  F+   ++L    T  ++ +   P    E   
Sbjct: 803  QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 861

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946
            ++ Q +  +     ++  +P I+++      L E   G  F +   +VA    + Q+  D
Sbjct: 862  IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 920

Query: 3947 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4004
            V+ R   L          ++ + +  I   +++   +L  P     + E +++++ E + 
Sbjct: 921  VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 980

Query: 4005 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            +   +++ Q     L    +EM   S     +IS K  Q + +++   W+ + + + E  
Sbjct: 981  LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1036

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4123
             KL + M    K      +L   + +   F+++ E P + D  ++K+Q +    +  +I 
Sbjct: 1037 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1095

Query: 4124 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4182
             +Q  L+ V N G + I    EP+    ++  + ELN+ WD + +    R + L+  ++ 
Sbjct: 1096 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1154

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
             V  Q  L  + +W+  A  +           + +++ +EE+K+ K EA Q++ +++ L 
Sbjct: 1155 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1214

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4302
                 ++ +    + +  ++  L  L   +  L  R+  +   LE       +    L++
Sbjct: 1215 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1273

Query: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4362
               WL   E  L   + + G  + I   L     L+N +   +     +      L +  
Sbjct: 1274 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1330

Query: 4363 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4422
              +E  N   +LE  N RW+ + E+  +R++ L+ +++ A+     +  +Q+ LT  ++ 
Sbjct: 1331 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1388

Query: 4423 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4478
            L A          +P+ A++   +  ++ +   + EE     M+K  Q      K A   
Sbjct: 1389 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1435

Query: 4479 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4538
            +   I+  ++K + V  K                 F   LQ+    L + +  L      
Sbjct: 1436 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1487

Query: 4539 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4598
            S+  + V  Q++        ++  + ++  + KTG  +    Q ++   +   + +++  
Sbjct: 1488 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1547

Query: 4599 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4658
            + ++  ++ ER + L+   K +++  +  + L EWL  ++  L     +   P  + +++
Sbjct: 1548 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1607

Query: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4718
            A  K  QK +  +     +    G +L  KT L      ++D LS L   W  +  ++ E
Sbjct: 1608 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1665

Query: 4719 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4778
              N L E       F   +  +  W+ + +  L E +             D  K  + EL
Sbjct: 1666 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1720

Query: 4779 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837
                  V + +  A  L+    D     V+ Q+ EL+ R+  +      K  +    L++
Sbjct: 1721 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1778

Query: 4838 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4896
             E+F+S +  LLE L AE +Q     GV   +ED  + + + ++  +K+L ++   L + 
Sbjct: 1779 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1833

Query: 4897 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4954
             T                          R  E +   +Q  Q   +AL  L +  +++ L
Sbjct: 1834 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1869

Query: 4955 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5004
            E    W Q+          L D +K++     P++  ++K +  E Q   EE+   +   
Sbjct: 1870 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1929

Query: 5005 DKVTKTYKRRAADPSSLQ 5022
            + +++     A +P+ +Q
Sbjct: 1930 EGLSEDGAAMAVEPTQIQ 1947



 Score =  221 bits (563), Expect = 2e-56
 Identities = 112/231 (48%), Positives = 153/231 (66%), Gaps = 5/231 (2%)

Query: 31  DERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMR 89
           DER+ VQKKTFTKW+N    K  K H+ +L+ DL+DG  L+ LLE L+G  LP+EKG  R
Sbjct: 7   DEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTR 66

Query: 90  FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDI--HVTGE 147
            H L NV  AL  L+   V LVNI + DI DGN KLTLGLIW IILH+Q+ ++  ++   
Sbjct: 67  VHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAG 126

Query: 148 SEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-Q 206
            +  ++++ LL W +Q+T  Y  +   NFTT W DG   NA+IH +RPDL D N+V   Q
Sbjct: 127 LQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQ 186

Query: 207 SNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 256
           S    LEHAF +A  ++G+ +LLDPEDVD + PD+KS++ Y++SL+   P+
Sbjct: 187 SATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 237



 Score =  205 bits (521), Expect = 1e-51
 Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)

Query: 3466 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3525
            ++H  H  Q +++  +     +   K   +S   ++Q  Y+   + + S           
Sbjct: 264  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 322

Query: 3526 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3572
             K FG    E EV L  +   + + LS L   + + +   +  +++ V+++         
Sbjct: 323  DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 382

Query: 3573 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3629
             D+   +  V   L  G +L+   + + DE   +Q+++  + +R++ +   S +    L 
Sbjct: 383  MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 442

Query: 3630 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3687
            + L   +  +   +EL  WL K E      E + L    E+  +   + K L+++ +  +
Sbjct: 443  RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 500

Query: 3688 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3747
              ++SL  +   + E     A   LE+ +    +R+  +      +   +   +L+ Q+ 
Sbjct: 501  VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 560

Query: 3748 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3807
             +      +W++E E                     V K  T       +++  L K   
Sbjct: 561  TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 600

Query: 3808 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3867
             ++ A  E++KQSM K     LK  D +  + ++   Q  + ++ ++ F   ++ L   L
Sbjct: 601  -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 654

Query: 3868 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
             ++ + ISQ      P+L   T+ +         +++ +H    +++    PQ       
Sbjct: 655  EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 705

Query: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984
                 +++ +  D+       +++KR   LD  I++   +  + + +L+S E  + R   
Sbjct: 706  -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 749

Query: 3985 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
                      +KE+++  +    +   KLQ    + +   E+M+      ++ ++A +++
Sbjct: 750  -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 798

Query: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4103
               +Q+   W     L+ ER    L+       F+     L       +++++       
Sbjct: 799  QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 857

Query: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4163
            +P+ +K Q +  +     + GLQ +++    L  + IA   +   P+    +D    A+ 
Sbjct: 858  EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 911

Query: 4164 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4217
            +  K     +   E+ +Q        ++YQ+ + A+  WV  +  KL+      TD E +
Sbjct: 912  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971

Query: 4218 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4277
            +Q++ EL+  +S   +QQ  +  L+   + + KK   E  +   Q    E++  W  L  
Sbjct: 972  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1030

Query: 4278 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4337
            +++    KLE  +  L + Q+ +  L  W+   +  L E+ P  GD + ++ +L +  +L
Sbjct: 1031 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1090

Query: 4338 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4397
             +D+   Q ++ +VN+ G  +   +  E AS L+ +L+ LN +W ++ ++   RK+ L G
Sbjct: 1091 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1150

Query: 4398 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4457
             L +      ++ ++ +W+T  E   L        P+  ++ +          + KE   
Sbjct: 1151 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1210

Query: 4458 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4517
            K L +    ++A+ P  A+  + +++  L   ++ + T+LN +   LEE      E  + 
Sbjct: 1211 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1270

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
            L+    WL + E  L          + +   +D  +        +  QI  L +T T   
Sbjct: 1271 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1330

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637
               +     LI   L +  SRW ++ +  V R + L+ + + A++  ++   + E L   
Sbjct: 1331 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1385

Query: 4638 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4686
            +K L + +       ++  +  KI++ L  H    +E +K    K +     ++   + K
Sbjct: 1386 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1445

Query: 4687 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4746
                      KL D+  + R     +  K    + +L+E+ +   +    L AL      
Sbjct: 1446 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1484

Query: 4747 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4805
             E +  E + V   ++  +NL        K L +  S V+ + ++ R++++  + ++   
Sbjct: 1485 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1536

Query: 4806 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4865
            +  ++  L   +  + A    ++ +LE  L+ + +    ++ L EWLA  +  L     +
Sbjct: 1537 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1596

Query: 4866 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925
                  L + +   K   K++E+++  L   T +G+ +  +      T ++  ++++ + 
Sbjct: 1597 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1655

Query: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985
            +  V + A++    L      +    + ++ +  W+  A+T L + +K+   Q+ + +K 
Sbjct: 1656 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1715

Query: 4986 LIAE 4989
            L AE
Sbjct: 1716 LKAE 1719



 Score =  184 bits (467), Expect = 2e-45
 Identities = 494/2698 (18%), Positives = 1056/2698 (39%), Gaps = 384/2698 (14%)

Query: 1170 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1229
            KLK +N  L  T+          T+  EEE +  D  +++  +   K  + ++++++   
Sbjct: 452  KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 503

Query: 1230 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1289
            ++L   +     + DE    +    L+     E+   L +RW N+    ++R   L+ I 
Sbjct: 504  NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 553

Query: 1290 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1347
              LK+ R T        W+ + E    KI     ++   + + L +  +L +++E K+  
Sbjct: 554  -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 612

Query: 1348 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401
            M +     +   +T+K+  +   T      +    D+  +   K     S A    Q  +
Sbjct: 613  MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 672

Query: 1402 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1454
               T    + T+ T+    +K A + L     ++K   +++ E ++ ++    EL  W++
Sbjct: 673  TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 732

Query: 1455 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1504
                 L+  E     K G     K+K+++   E + K  +L +A ++ Q  + +  +   
Sbjct: 733  RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 792

Query: 1505 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1547
                 K   E+ N         L +++  L+   N++ F   L+QL++  T+ +  +K+ 
Sbjct: 793  NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 852

Query: 1548 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1594
                 E   +  + +  K+++  +  L  Q E   I        G    F+  D      
Sbjct: 853  PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 912

Query: 1595 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1639
             +       Q++++ELQ           Q +  A+   V+ +E   K +  +LS  D  +
Sbjct: 913  HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 970

Query: 1640 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1699
            +EQ+L E  ++  Q +L+ +QS       ++T +KE ++K  +     E   K ++  + 
Sbjct: 971  MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1020

Query: 1700 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1759
            +    K       +H Q +E+     Q    +        +   + E DV  +       
Sbjct: 1021 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1075

Query: 1760 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1819
             ++  +K   Q   ++S  Q +  +  S     +K      PE   +L+  +KEL   ++
Sbjct: 1076 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1135

Query: 1820 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1879
                +   + +      E+      D +E   W+ Q+E+E    +      + L   ++ 
Sbjct: 1136 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1195

Query: 1880 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1939
             K   E+    +  ++ +T S N V+  A   ++              ++++L+  T  +
Sbjct: 1196 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1243

Query: 1940 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1999
            + L   C  L    K L + +  + +    LL+ L+     A+K L+E        ++ +
Sbjct: 1244 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1284

Query: 2000 LEETKALQG---QISSQQVAVEKLKKTAEVLLDARGSLLPAKND-------IQKTLDDIV 2049
            L+ T+ + G   +IS    ++E L + +E   +    L     D       I + L+   
Sbjct: 1285 LKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFN 1344

Query: 2050 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-------EQGQVPL 2102
             R+ +L +    R + L+ ++  +   +  L  + + +  ++  L        +  Q+P 
Sbjct: 1345 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQ 1404

Query: 2103 NSTALQ-DIISKNIMLEQ---DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2158
             +  +Q D+ S  I LE+      G++++   +++      +  D S    L  K  +  
Sbjct: 1405 EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE 1464

Query: 2159 ARFSEASHKHKETLAKMEELKTK--------------VELFENLSE---KLQTFLETKTQ 2201
             R  E+     E    +  L+TK              V L+++LSE   +++  ++T  Q
Sbjct: 1465 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 1524

Query: 2202 ALTEVDVP-------------------GKDVTELSQYMQESTSEFLEHKKHLEVL----- 2237
             + +                       G  VTE  Q +++      + +K + VL     
Sbjct: 1525 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1584

Query: 2238 ---HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL 2294
                 L K  +  G+PS+    +       K+ ++ +  +K   E   + +  L   + L
Sbjct: 1585 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1644

Query: 2295 VKSLKS-----WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2349
            V+   S     WI  T++          AE+    L + +K  E +      I K     
Sbjct: 1645 VEDKLSLLNSNWIAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1694

Query: 2350 ISLCNLISAVTTPAKAIAAVKSGGAVLNG-----EGTATNTEEFWANKGLTSIKKDMTDI 2404
             +L +  S    P +    +K   A LN      + T        AN+G           
Sbjct: 1695 DTLLD-ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----------- 1742

Query: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2464
                +    L++ +I+ELN + + +    +   A +  L+++ +  +  Q+   P + E 
Sbjct: 1743 ----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLEPLEAEI 1797

Query: 2465 VKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2523
             +    + + F  ++ + N   V+EL  +   L +   D  +    K     + +K   L
Sbjct: 1798 QQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1857

Query: 2524 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2583
              L   R++K  E S+   Q++     L + L + E  ++ L P   D   +    +++Q
Sbjct: 1858 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQ 1916

Query: 2584 ILLQEFATRKPQYEQLTAAGQGILSRP-------------GEDPSLRGIVKEQLAAVTQK 2630
               +E    + Q E L+  G  +   P              +    R +   Q+  V ++
Sbjct: 1917 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1976

Query: 2631 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2690
                T  +      ++ + V ST Y + +  +S  L +++  L++    +   + + +Q 
Sbjct: 1977 ----TMMVMTEDMPLEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 2031

Query: 2691 ETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQLEGILKSFK 2742
            E+ + +K  +QQ   +I +  +  +  +AL        VK +   ++L  Q E + K +K
Sbjct: 2032 ESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2089

Query: 2743 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH-PISAKLDVLESLIK 2801
            D + + +  V+  +        F Q   + + +L   +  +N  H      L  L+  I 
Sbjct: 2090 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2149

Query: 2802 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERE 2861
              +   +TL           A GE ++ ++  ++ + LQ +L ++   W    KQ+ +R+
Sbjct: 2150 QRQTVVRTLN----------ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2199

Query: 2862 NKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE---NSIAKLKSLQKEM 2918
             +L+E      +++  +     W+++  +N+  I   L+P + +     + ++K L +E+
Sbjct: 2200 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLEQVKLLVEEL 2256

Query: 2919 DQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK-------------------------- 2951
                G+++ LN T   +L    I  E     ENK                          
Sbjct: 2257 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2316

Query: 2952 ----SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-----SKRQLQCAKEQLDIH 3002
                 L +K++ + EQL+     L  +  + + + + ++E      + ++    +Q D+ 
Sbjct: 2317 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2376

Query: 3003 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD---------SKGTS 3053
            + L    +  K     Q  ++ L+ L  +     RL Q+L  +  D         +  T 
Sbjct: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2436

Query: 3054 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3113
             V L  + +  + + +S+   E  S L  ++  +  F     E+    +  D  + S   
Sbjct: 2437 TVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2494

Query: 3114 VGRDAETLQ----KQKETIKAFLKK---LEALMASNDN-ANKTCKMMLATEETSPDLVGI 3165
            +  D E +     KQK T++   ++   LE L+ +  N  NKT      T  T       
Sbjct: 2495 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD------ 2548

Query: 3166 KRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVG 3225
               +E +  Q +++ +  Q R +Q+   +K   ++    +E   +L +A    ES     
Sbjct: 2549 --RIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2606

Query: 3226 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3285
               + I +++   K   K ++   Q      N L   L++  + +  T+ +    +++NA
Sbjct: 2607 YTVDAIQKKITETKQLAK-DLRQWQTNVDVANDLALKLLRDYS-ADDTRKVHMITENINA 2664

Query: 3286 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----ANQKPPSAE-F 3339
             W++++K+V++R A L+E      +F   LE  L+W+ + E        A +K    E  
Sbjct: 2665 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2724

Query: 3340 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEA 3398
            K VK  +++ + LQ  ++        +    +KI  + E +D   +L ++L  ++ +W  
Sbjct: 2725 KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 2784

Query: 3399 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3458
            L  K+      LE  S   ++ H +L+ L  WL   +  L    PIG     +++Q   H
Sbjct: 2785 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 2844

Query: 3459 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3518
            +A + ++      +   +S  +++++  + +  + ++    + +   +  +E++ + + L
Sbjct: 2845 RAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPEERAQNVTRL 2899

Query: 3519 LQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3577
            L++         E   +   +W  ++ + L +L     +T+ L     +L++ Q +++  
Sbjct: 2900 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKG 2954

Query: 3578 K-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3634
              Q V   L++ L              QD LE +KA   +I  L  +V+   + A QL
Sbjct: 2955 SWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHVNDLARQL 2998



 Score = 38.9 bits (89), Expect = 0.14
 Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)

Query: 608  VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666
            +Q+LL W+     +L R    G D P+V+       +VHRA +  E   KE  I     T
Sbjct: 2810 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2864

Query: 667  APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 726
              + LT  + L  LE  Y         + R L        RA N +  L  K+ EEV  +
Sbjct: 2865 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2910

Query: 727  WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 774
            W + N        + A+  R++D+  E ++ +QE  ++L L+   A +
Sbjct: 2911 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2951


>gi|5032285 dystrophin Dp427l isoform [Homo sapiens]
          Length = 3562

 Score =  325 bits (832), Expect = 1e-87
 Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)

Query: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2238
            ++ QT LE     L   +   +   E+S  ++    +F  H+ ++            +L 
Sbjct: 219  DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 278

Query: 2239 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297
               K I +  L  D+   V E+ N L+ +++ +     EK+  +   +  +D     +K 
Sbjct: 279  LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 336

Query: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
            L  W+ +T ++   ++     E LG  LED K+  ++  +   ++++      SL +++ 
Sbjct: 337  LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 392

Query: 2358 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2415
             V   +   A AA++    VL            WAN            I    ED  +LL
Sbjct: 393  VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 431

Query: 2416 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2475
            +D        L K Q+  EE      WL +      K   T      E + + +++    
Sbjct: 432  QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 483

Query: 2476 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2531
            +A+L   KQ++ K+  LK  L   L+    T +   W        D+  Q+L + T    
Sbjct: 484  KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 543

Query: 2532 QKLEESSNNLTQFQTVEA------------------------------------------ 2549
            Q +  +  +LTQ   +E                                           
Sbjct: 544  QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 603

Query: 2550 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605
               +L  W+   E ++ S    +       +  +++V  + +E A +  + +  + + Q 
Sbjct: 604  DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 663

Query: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665
            ++ +   +      +K+    +  +W      LS+R +W++        + + L+ L   
Sbjct: 664  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 722

Query: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2724
             +  +N L       + P A+  QL+  +     +   + QI+  +      S  +KE+ 
Sbjct: 723  TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 778

Query: 2725 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2780
                +L A+         + F DV+ + E  +Q +        ++Q+     + W+   +
Sbjct: 779  QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 836

Query: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840
             + +         +++E  + + +    +L  Q           + +  K         Q
Sbjct: 837  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 896

Query: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
             +   I+  W   + Q+ E   KL+E + K  K +  ++TL  W+ +    L+E      
Sbjct: 897  SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 952

Query: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2949
            PA G++ I     L+K++ Q   +V  +     SL SV E  +++  +           E
Sbjct: 953  PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1007

Query: 2950 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3009
             K L  + D + +Q++++K  L+   +K    Q+   E    +  A+E+    D      
Sbjct: 1008 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1061

Query: 3010 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3069
            +  K    LQ   + ++  K +    K     L+ E+ +S       +  E + +E  TL
Sbjct: 1062 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1120

Query: 3070 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3129
            +      C+ L  K + +        E+ S   + +  L+ +    +  E +    E I 
Sbjct: 1121 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1180

Query: 3130 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3186
              L  LE LM  S DN N+    +LA   T   ++   I  +LE  + +  +L + A  R
Sbjct: 1181 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1238

Query: 3187 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3237
            ++ +E +I+  +E    L   +E    + K      A++ + +Q P   E + I   L  
Sbjct: 1239 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1296

Query: 3238 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3297
             ++  +E  +  QGK+     L Q  I  A K          L DV+ +++ L +K A  
Sbjct: 1297 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1344

Query: 3298 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3357
              +LQE+ +     +  L +L              +  S E +VV++Q+     L + L 
Sbjct: 1345 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1390

Query: 3358 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3417
            + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +QLE    ++
Sbjct: 1391 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1450

Query: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3477
            ++  + +  L EWL   +  L     +    S L+ ++A  KA + +I     HL     
Sbjct: 1451 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1510

Query: 3478 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3537
            +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + F ++   + 
Sbjct: 1511 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1569

Query: 3538 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595
             W+ +    L  S+        + L + ++EL  ++  +   +      + N  +  ++ 
Sbjct: 1570 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1629

Query: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655
               ++  +  +  AI  R K  T  ++   K LEQ     ++L          L+ +E E
Sbjct: 1630 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1677

Query: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715
            +   +   LK E+ +      K++ ++  N   + + L    +    +   R RE ++  
Sbjct: 1678 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1727

Query: 3716 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775
                  ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL SL + R E+
Sbjct: 1728 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1787

Query: 3776 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831
               +   +LQ +K     + R  + +  D    +        S+  ++   K       N
Sbjct: 1788 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1847

Query: 3832 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3886
            +  I  +  E  + +     L ++    TY      +   L E + +++     A ++E 
Sbjct: 1848 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 1907

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3945
            L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     D  + ++ +
Sbjct: 1908 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 1967

Query: 3946 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4002
              K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  K K  + E 
Sbjct: 1968 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2025

Query: 4003 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4062
            ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W+ +   + +
Sbjct: 2026 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2078

Query: 4063 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4122
            R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E  + + EE+
Sbjct: 2079 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2137

Query: 4123 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4178
               Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A  ++  ++E 
Sbjct: 2138 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2195

Query: 4179 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4234
             ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    +++ +     +
Sbjct: 2196 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2252

Query: 4235 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4278
            Q ++E +  + + L K K   +  K  ++D   E K +   L+E                
Sbjct: 2253 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2312

Query: 4279 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4316
                         ++ ++    KLE   +L+    AL  F  A  EL  WL+  + ++  
Sbjct: 2313 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2372

Query: 4317 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4375
            Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA  +  +++E
Sbjct: 2373 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2432

Query: 4376 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
             +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + K      + 
Sbjct: 2433 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2492

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4495
             ++++    ++       +           ++L          +     N+   W S+  
Sbjct: 2493 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2552

Query: 4496 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4549
            +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+    V   +
Sbjct: 2553 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2612

Query: 4550 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4608
             + +    E+ +H +    LD+     L+      D VL++  L ++  +W ++ ++ + 
Sbjct: 2613 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2672

Query: 4609 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4668
                L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q   H+ F++ L
Sbjct: 2673 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2732

Query: 4669 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4709
              K  V  +T  T                    R L  +    +    L     E+  +W
Sbjct: 2733 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2792

Query: 4710 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4767
            + +   S + Q K++E L    +  +A   L   L + E      QPV GD  ID + + 
Sbjct: 2793 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2851

Query: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
            ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+ +       
Sbjct: 2852 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 2904

Query: 4828 QTRLEAALRQAEEFH 4842
            Q  +E  +RQ  E H
Sbjct: 2905 QVAVEDRVRQLHEAH 2919



 Score =  316 bits (809), Expect = 5e-85
 Identities = 548/2809 (19%), Positives = 1128/2809 (40%), Gaps = 353/2809 (12%)

Query: 1839 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1898
            L+++     E   WL  +E  L+     ++D+  +  +    + +  D+ +H+G +  I 
Sbjct: 218  LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 277

Query: 1899 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1958
              G++++   K     +           EVQ +++    R+  L        +NL  ++ 
Sbjct: 278  QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 327

Query: 1959 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2018
              Q+ +     L   L   E    K   EP+  D ++L+RQ+++ K LQ  +  +QV V 
Sbjct: 328  DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 385

Query: 2019 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2077
             L     V+ ++ G    A  + Q K L D   R+ ++ +   +R   LQ  L +   + 
Sbjct: 386  SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 442

Query: 2078 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2131
            +       W+   E ++ +     +++T  +D       + K  +L+ D+  ++ S+  +
Sbjct: 443  EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 497

Query: 2132 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2190
                +  + T  + S     +A + + +  +     K +++ A++ +  T  +   +L++
Sbjct: 498  YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQ 555

Query: 2191 KLQTFLETKTQALTEVDVPGKDVTEL-----SQYMQESTSEFLEHKKHLEV----LHSLL 2241
               T +ET T   T   +  K   E       Q  ++ T +  E +K L+V    LHS +
Sbjct: 556  T--TVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-EIRKRLDVDITELHSWI 612

Query: 2242 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2278
               S   L S +  +  K  N S              +KF++++D  +  +         
Sbjct: 613  TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 671

Query: 2279 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2330
                +++    EQL++    F  L+    +W++     +         E +  + E+  K
Sbjct: 672  GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 731

Query: 2331 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2389
            +Q      TP       S + +C + ++ ++     I  +K     L  +G         
Sbjct: 732  IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 778

Query: 2390 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2447
              +G   +  D    ++ ++ +   ++ +  EL T    L   + QE  SA+  W+Q+ +
Sbjct: 779  --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 835

Query: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507
            +T     Q    TD E ++ ++ + ++ ++ L++  + +  L   + E+ ++ P +  + 
Sbjct: 836  ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 893

Query: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567
            +++    EI+ +W++L+   ++  QKLEE  N L + Q     LK+W+ E ++ +    P
Sbjct: 894  KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 953

Query: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2627
               D  +L  Q +Q ++L+ +  T +P    +   GQ I +    +P     ++ +L  +
Sbjct: 954  ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1011

Query: 2628 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2687
              +WD +  Q+  R + +   + K+   Q  L  + + ++  + +          PD + 
Sbjct: 1012 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1071

Query: 2688 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2745
            + +E  ++ K+E QQ++ ++K+   L E +++++ +    A+  L ++LE +  +++ + 
Sbjct: 1072 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1128

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2798
             +     + L+   A  H+          WL+       T +     +  IS  LD LE+
Sbjct: 1129 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1188

Query: 2799 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2842
            L++  +D        ++TLT    M E    E E    + +   + A++ Q         
Sbjct: 1189 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1248

Query: 2843 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2874
                   L+ I+ +    +KQ+              +   K++        SLE+  K+ 
Sbjct: 1249 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1308

Query: 2875 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2927
              KE  + +   ID  Q  L+++  KF L   PA  E  + + K +  E+  H   +E  
Sbjct: 1309 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1368

Query: 2928 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 2975
                      LN+  N   S+ E+  EV  V    + ++QK     +Q  + K   E +T
Sbjct: 1369 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1423

Query: 2976 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3031
                 + E+     E K+QL+ C K    +   +           M  T++ +++ +   
Sbjct: 1424 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1483

Query: 3032 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3087
            +D      K   +++  +    K  ++V   ++T+  +  TL   V++K S L +    +
Sbjct: 1484 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1540

Query: 3088 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3143
                  + N + E       FD  +D +      A+TL  + E  K   K+ + L     
Sbjct: 1541 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1599

Query: 3144 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3196
              N     + +T + + +L+  + D   + +  Q ++L  R  A   +++       +K 
Sbjct: 1600 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1659

Query: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
            LE+F S +++   LL+  E   E Q  V ++ E  N+ +N          E  +G  +++
Sbjct: 1660 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1704

Query: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
               G  L Q        + ++     +  +   L    +QR  +  E      +++   +
Sbjct: 1705 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1764

Query: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3373
             LL  + D E+ +A+   P  E K+        K + R L  +K  +  ++R+ E +   
Sbjct: 1765 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1816

Query: 3374 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3417
              A   EP  ++++ K+   ++S++     LN A+            T +  LE IS V 
Sbjct: 1817 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1874

Query: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3474
              +   +  +++ L  +E+ L   +        L +Q    K ++D +   +  +   H 
Sbjct: 1875 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 1934

Query: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3534
              +          R       S+LDF    + ++ +    R     +++   + F  D  
Sbjct: 1935 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 1991

Query: 3535 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3594
                WL E    L K  + +      +K    L+ LQ+ I  R+  V      G E+++Q
Sbjct: 1992 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2049

Query: 3595 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3654
            ++  +  I+Q+KL ++  R++++ K  +D  K LE+   +         E   WL++ + 
Sbjct: 2050 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2108

Query: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3712
             + S   +  K ++  +   + K L +E    + +L  LNE    +L   P    E   L
Sbjct: 2109 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2168

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3765
            E  + + N ++  VS  + +K  EI+A I        + +  ++  +  L W++    +L
Sbjct: 2169 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2228

Query: 3766 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825
                     Q        VQ+T      +  D+ + L K  H       +   Q +K+KL
Sbjct: 2229 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2280

Query: 3826 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3871
            + +   +  + ++  E R  Q + A              +LV Q   T E     L    
Sbjct: 2281 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2340

Query: 3872 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3914
            S++ ++PA A              L  + ++ Q+    +   + E+I + K  +  + + 
Sbjct: 2341 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2400

Query: 3915 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3962
             PQL EL           S  E  +I  ++       + +++E ++ R   L+E +  ST
Sbjct: 2401 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2460

Query: 3963 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4019
            Q+    ++ +Q+L      +E  ++ P     V+ I+++I+E K ++ D+ + Q   +  
Sbjct: 2461 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2517

Query: 4020 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4079
                 +++ R    D       + + ++     W +IH  V EREA L +   L ++F  
Sbjct: 2518 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2573

Query: 4080 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4135
            D    +  + + +     L+D      +++  +   E +++  D LQ E+    D+  NL
Sbjct: 2574 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2632

Query: 4136 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4191
                   L +  G  D  ++++ +D +N  W  L K   +    LE +     +    LQ
Sbjct: 2633 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2692

Query: 4192 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4233
             +  W+ +   +L+  +PIG D   V++Q +  + FK E                    +
Sbjct: 2693 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2752

Query: 4234 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4292
            Q +E +E+L  +   L  +   ++    ++    E+   W+ L     + Q K++  L  
Sbjct: 2753 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2812

Query: 4293 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
            L + Q A DEL   L   E +    +PVG     +++  L K   L+ ++   +  V  V
Sbjct: 2813 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2872

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4400
            N     L          NL + LE LN RW+ +    E R +QL  A R
Sbjct: 2873 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 2920



 Score =  313 bits (803), Expect = 2e-84
 Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)

Query: 2373 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2432
            G+ L G G  +  EE       T +++ M  ++  +E L +   +K + L+  L  LQ  
Sbjct: 280  GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 331

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2492
             ++   +  WL K  +   K ++ P   D E +K QV+Q+K  + +L+Q   +V  L   
Sbjct: 332  -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 390

Query: 2493 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2552
            +  + E + D   A   +Q L  +  +W  + + T DR   L++      +    +    
Sbjct: 391  VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 449

Query: 2553 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2611
             WL EKE  V+ +      D N + +  Q++ +L  +   +K    +L +  Q +LS   
Sbjct: 450  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 508

Query: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2654
            ++ S+    +  L    + WD+L  +L      I QA+  +                 T+
Sbjct: 509  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 568

Query: 2655 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2696
             Q L++   ++L            +D+++   L V         T  +A+ Q  E A   
Sbjct: 569  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 628

Query: 2697 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2736
            K+            I++EK +         + AQAL E + +  V  + +K + S QL  
Sbjct: 629  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 687

Query: 2737 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2795
                F  +  +  N +++  +  A  +Q QQ+ +     + T  E   K  P + ++   
Sbjct: 688  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 742

Query: 2796 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2855
            ++S +K  KD    L+      E+   + +++ LK +G     L         ++     
Sbjct: 743  IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 800

Query: 2856 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2912
             V+ RE +L+   +    ++Y+E +  +  W+ + +  L   +  +   E  E  + +L+
Sbjct: 801  DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 860

Query: 2913 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 2972
            +LQ  + +    +  L+ T      V E+ K+  ++ ++    + + +  +       L 
Sbjct: 861  ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 914

Query: 2973 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3024
               QK +E     ++ +  +Q  K+   ++D+       +LG      K L   +     
Sbjct: 915  EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 974

Query: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3084
            +Q ++  ++      Q +  EA + +  S +  +++ +  +   + QQV  +   L+  L
Sbjct: 975  IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1033

Query: 3085 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3144
            +     Q  + EM     + ++E        +  + LQK  E +K          A  + 
Sbjct: 1034 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1084

Query: 3145 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3196
              K  K+ L TE  +  +          +K++LE L+     L  R   + + +E     
Sbjct: 1085 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1144

Query: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
              E  S L++ +  L + E   ++   +    E I++ L+  +   +      +     +
Sbjct: 1145 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1200

Query: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
              L Q L          + +  +L+  N+RW+ L+++  +R   L++++      Q A E
Sbjct: 1201 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1251

Query: 3317 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3373
            +  S  +  E L    K  +A    KV  AQ+ QE + +Q  L   + ++E +K+  +  
Sbjct: 1252 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1311

Query: 3374 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3432
                    ++ +  K+L  +  ++      A    R  E   +        L+ +   L 
Sbjct: 1312 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1363

Query: 3433 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3492
             +E + V  E + +Q   L   +  +K+L +        +   +  G+ +      E+  
Sbjct: 1364 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1416

Query: 3493 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3552
             +  ++   ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S 
Sbjct: 1417 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1476

Query: 3553 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
             +     L  + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + +
Sbjct: 1477 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1535

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
             +  +T  + +    L +  +         + +  W+  ++ + L  E++  K ++    
Sbjct: 1536 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1593

Query: 3673 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732
                K LK E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  
Sbjct: 1594 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1648

Query: 3733 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3792
            K  +    +   +QF+              +KL+   +  ++Q     +    K    + 
Sbjct: 1649 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1696

Query: 3793 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3851
              ++  + +L++ G  +    ++E K + +K K   +   ++ +  + S+R  +      
Sbjct: 1697 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1754

Query: 3852 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3911
               Q+    ++L   L + +  ++ LP P            + R+++E+  E +   +++
Sbjct: 1755 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1803

Query: 3912 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3967
            N    Q   LS  G   +++   +     + +I+      ++   A    + + T     
Sbjct: 1804 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1863

Query: 3968 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4027
             D  LE        L +   +S  + ++++ ++     + D E L    E+LK   + + 
Sbjct: 1864 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 1923

Query: 4028 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4074
              SG  D   S K              +Q+ L Q+ F WE ++ + ++R+ +    +E  
Sbjct: 1924 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 1983

Query: 4075 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4131
             +F  D       + + + F+R  + P        +  E A+    ++E  DG+ +   +
Sbjct: 1984 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2035

Query: 4132 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4188
            V  L   G E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q 
Sbjct: 2036 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2095

Query: 4189 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4248
             L     W++ A   +AS+       + +K+++E++K    E   +Q  +++LN     +
Sbjct: 2096 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2154

Query: 4249 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4303
            L       EE DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L  
Sbjct: 2155 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2212

Query: 4304 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4356
                 L WL+     L    Q    G     E E+A        V A Q  VE +   G 
Sbjct: 2213 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2264

Query: 4357 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4384
             L +     +   ++ KLE L+  W+ V                                
Sbjct: 2265 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2322

Query: 4385 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
                  ++T   K ++  +L         F+    +L  WL+  ++ + + + + G  E 
Sbjct: 2323 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2382

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4494
              E +          E +    + L+   Q +  +   + A T I   I  ++ +W+ V+
Sbjct: 2383 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2442

Query: 4495 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4554
              L  R+ +L E L  + ++  + ++    L QA   L         +D +  +I E K 
Sbjct: 2443 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2502

Query: 4555 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4614
             A ++   +  +   +     L       D   +  +  ++ + W  + +R+ ER  +L+
Sbjct: 2503 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2562

Query: 4615 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4668
            +  +  +QF     K + WL E+E + +       +  +  D   +K  + Q ++ Q  +
Sbjct: 2563 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2622

Query: 4669 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728
             A   VY   +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +  
Sbjct: 2623 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2682

Query: 4729 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4782
               +   +LQ L+ WL   + +L+   P+ GD   V    D H+AF++EL  +       
Sbjct: 2683 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2742

Query: 4783 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
                           ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   
Sbjct: 2743 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2802

Query: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887
            Q +++  L + +E       L   L +AE        + D       LID  ++ ++K++
Sbjct: 2803 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2856

Query: 4888 EKRAEL 4893
              R E+
Sbjct: 2857 ALRGEI 2862



 Score =  308 bits (789), Expect = 1e-82
 Identities = 502/2696 (18%), Positives = 1071/2696 (39%), Gaps = 346/2696 (12%)

Query: 2650 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2709
            V   +YQ+ L  +   L   ++ L +   +S   + +  Q  T +    ++   + ++  
Sbjct: 216  VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 275

Query: 2710 AQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQM 2768
               L   L    K  E  + E+  Q+  +L S  +  + A    Q          Q Q++
Sbjct: 276  ILQLGSKLIGTGKLSEDEETEVQEQMN-LLNSRWECLRVASMEKQSNLHRVLMDLQNQKL 334

Query: 2769 SRDFQAWLDTKKEEQNKS---HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
             ++   WL TK EE+ +     P+   L+ L+  ++ HK   + L  Q  +   ++    
Sbjct: 335  -KELNDWL-TKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLE-QEQVRVNSLTHMV 391

Query: 2826 NLLLKTQGSEK-AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2884
             ++ ++ G    AAL+ QL  +   W    +  ++R   L++ L K  +  E+      W
Sbjct: 392  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 451

Query: 2885 IDKCQNNLEEIKFC--LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2942
            + + ++ + +I      D  E  +S+ KL  L+ ++++    +  L +    LLS   + 
Sbjct: 452  LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST--LK 509

Query: 2943 KEVVTDENKS-----------LIQKVDMVTEQLH----------SKKFCLENMTQKFKEF 2981
             + VT + ++           L+QK++  T Q+           ++   +E +T      
Sbjct: 510  NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 569

Query: 2982 QEVSK-----------ESKRQLQCAKE---QLDIHDSLGSQAYSNKYLTMLQT------- 3020
            Q + K           + KRQ+    E   +LD+ D     ++  +   +LQ+       
Sbjct: 570  QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV-DITELHSWITRSEAVLQSPEFAIFR 628

Query: 3021 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQ--------VETIAQEHSTLSQQ 3072
            ++ +   LK +V+  +R   +   +  D+  ++  L++         ++I Q    L+ +
Sbjct: 629  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 688

Query: 3073 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3132
              E C  L  +L  +  +QN I   ++Q  + +    +     +   T   +   IK+ L
Sbjct: 689  WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 747

Query: 3133 K----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3188
            K    ++  L        +     +A +E     + +  D  A +    ++    QARE+
Sbjct: 748  KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 807

Query: 3189 QVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3246
            +++     L    +   +      +Q++E           + E + Q+L   +  Q    
Sbjct: 808  ELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSS-- 865

Query: 3247 EPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3304
              LQ +Q  + +L   + + + K+ S  ++  + + +++  RWK L+ ++ +   +L+E 
Sbjct: 866  --LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 923

Query: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3364
            +    + Q+ +++L  WM + +  +  + P   + +++K Q+++ +LL   +   + ++ 
Sbjct: 924  MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLN 983

Query: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3424
             +   G+KI   AEP    ++  +L  L+++W+ +  +   R   L+G         + L
Sbjct: 984  SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDL 1043

Query: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3484
              ++EW+T  E+  +  +       +L++ + + K  +++       +        S+  
Sbjct: 1044 SEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1103

Query: 3485 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKIFGEDEVELMNWLNEV 3543
             +    ++ ++ +L+     Y  +  + + + + L++   C  ++    E +   WLNEV
Sbjct: 1104 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE-KANKWLNEV 1162

Query: 3544 HDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL- 3601
              KL        +TE +     E+  VL     L + + D    N + +L QT  D  + 
Sbjct: 1163 EFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--NQIRILAQTLTDGGVM 1213

Query: 3602 --IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH-STH--EELCTWLDK----- 3651
              +I ++LE   +R++++ + +    K LEQ++Q A+    S H  +E  T++DK     
Sbjct: 1214 DELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1273

Query: 3652 ----------------VEVELLSYETQVLK------GEEASQAQM--------------- 3674
                            ++ +L S+E  + +      G+EA+Q  +               
Sbjct: 1274 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM 1333

Query: 3675 ------RPKELKKEAKNNKALLD-------------------------------SLNEVS 3697
                  +P   ++  + +K +LD                               SL+EV 
Sbjct: 1334 KFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 1393

Query: 3698 SALLELVPWRAREGLEKMVAED----NER-------YRLVSDTITQKVEEIDAAILRSQQ 3746
            S + E+V    R+ ++K   E+    +ER       Y  +   +T++ ++++  +  S++
Sbjct: 1394 SEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1452

Query: 3747 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806
              +  +    W+  T+ +L     +        +++   K    EI + K  +  + + G
Sbjct: 1453 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1512

Query: 3807 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866
              + T   ++E   ++ KL  +  N+  +     E    L   Q  +  F +  + +  W
Sbjct: 1513 EALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1571

Query: 3867 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3926
            + +  +++        E E  + QQ+E   L+ L AE      K++ T  Q   L    G
Sbjct: 1572 IIQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRG 1623

Query: 3927 FS----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 3982
                  ++ +    +  ++ I   +K    ++   + +  QF+  I ++LE LE  +++ 
Sbjct: 1624 DHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ- 1680

Query: 3983 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042
                 ++ + E   + ++E+   +V         + L QRG+ +  R     K    K  
Sbjct: 1681 ----GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIK 1727

Query: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4102
            Q  L         +  L  +R  K L++     ++      L+  + D +  +  L +P 
Sbjct: 1728 QQLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1784

Query: 4103 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4162
             D   +K+     +  +EE++ ++ + +    L  +  A   EP +  + K   E+ S +
Sbjct: 1785 -DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKF 1840

Query: 4163 DSLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSP 4209
                +    +I  + EE M    +            Y   +  V   +      L +   
Sbjct: 1841 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 1900

Query: 4210 IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4269
               D E + +Q E LK  K    Q    ++ ++ +    L+  T   ++  +Q+ L +L 
Sbjct: 1901 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLD 1959

Query: 4270 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIE 4328
              W+ + +   +RQ + + ++    +F + +     WLT  E  L + Q P   +    +
Sbjct: 1960 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2019

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4388
              L +   LQ+ +   Q+ V  +N  G ++I+ S+  +AS LQ KL  LN RWQ V ++ 
Sbjct: 2020 WYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2076

Query: 4389 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVC 4447
              RK++L+        F  ++ +   WL + +   +AS PL  G  +  KE+L     + 
Sbjct: 2077 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLV 2134

Query: 4448 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKL 4504
                 ++   K L + G  +L   P S E   D+  N LK+   +W  V   L E++ ++
Sbjct: 2135 EELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEI 2193

Query: 4505 EEALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFAN 4557
            E  +    +    L+D        + WL+     L + ++P+       F + E ++   
Sbjct: 2194 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI--- 2247

Query: 4558 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------ 4611
             V + +  + E+   G HL  + +K     +K  L  + S W K V RL++  R      
Sbjct: 2248 AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDL 2304

Query: 4612 ------------------------------------SLDDARKRAKQFHEAWSKLMEWLE 4635
                                                SL         F+ AW++L +WL 
Sbjct: 2305 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS 2364

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4695
              ++ + S+  +  D + I   + + K   + L  +    +      ++LK KTS  +  
Sbjct: 2365 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEAR 2424

Query: 4696 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4755
              + D +  ++++WD +      R+ +L E L  S Q+ +A +     L +   +L   +
Sbjct: 2425 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 2484

Query: 4756 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELS 4814
                 +D +   I   K   K+L +  ++V      A +L+   S DD+  V +  + ++
Sbjct: 2485 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 2544

Query: 4815 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT 4874
              W ++      ++  LE   R  ++F   +   L WL EAE T     VL D     R 
Sbjct: 2545 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERL 2601

Query: 4875 LIDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRA 4924
            L D    KE MK+ ++ + E+   T +   +         ++   D    ++  +  +  
Sbjct: 2602 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2661

Query: 4925 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK 4984
            ++ E+   +   +  L ++          L+ LL WLQ  +  L+ +    I  +   V+
Sbjct: 2662 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQ 2719

Query: 4985 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLY 5044
                 H+ F  E+  K+P +    +T +            I + ++   G ++     LY
Sbjct: 2720 KQNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LY 2762

Query: 5045 PSGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5092
                +   E +   V  L+ K        W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 2763 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2818



 Score =  295 bits (755), Expect = 8e-79
 Identities = 474/2585 (18%), Positives = 1053/2585 (40%), Gaps = 294/2585 (11%)

Query: 2534 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2593
            L ES  NL ++QT   ++  WL+  E  +   G +S D  ++  Q    +  + +    +
Sbjct: 211  LMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQ 270

Query: 2594 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2653
             +   +   G  ++            V+EQ+  +  +W+ L     ++   + + ++   
Sbjct: 271  GRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 330

Query: 2654 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA--MNQQLETAQKMKQEIQQEKKQIK--V 2709
              +  L+ L+D L+  + +          PD   + +Q++  + ++++++QE+ ++    
Sbjct: 331  NQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 388

Query: 2710 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2769
               +  D S+    ++  A L  QL+ +   + ++ +  E+    LQ       +  +  
Sbjct: 389  HMVVVVDESS---GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 445

Query: 2770 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2829
              F AWL  K++  NK H             KD  +   +L                   
Sbjct: 446  CLFSAWLSEKEDAVNKIHTTG---------FKDQNEMLSSL------------------- 477

Query: 2830 KTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID--- 2886
                 + A L+  L           KQ   +   LK+ L   LK K   +    W+D   
Sbjct: 478  ----QKLAVLKADLEK--------KKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 525

Query: 2887 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2946
            +C +NL +    L+ +  + S A + + Q  + Q   M  +   T    + V    +E+ 
Sbjct: 526  RCWDNLVQ---KLEKSTAQISQA-VTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 581

Query: 2947 TDE---------NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE 2997
                        +  + +++D+   +LHS     E + Q   EF    KE        KE
Sbjct: 582  PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS-PEFAIFRKEG--NFSDLKE 638

Query: 2998 QLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3057
            +++  +   ++ +       LQ   +S QAL               VE   ++G     +
Sbjct: 639  KVNAIEREKAEKFRK-----LQDASRSAQAL---------------VEQMVNEG-----V 673

Query: 3058 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3117
              ++I Q    L+ +  E C  L  +L  +  +QN I   ++Q  + +    +     + 
Sbjct: 674  NADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKI 732

Query: 3118 AETLQKQKETIKAFLK----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3173
              T   +   IK+ LK    ++  L        +     +A +E     + +  D  A +
Sbjct: 733  QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 792

Query: 3174 KQCNKLLDRAQAREEQVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3231
                ++    QARE++++     L    +   +      +Q++E           + E +
Sbjct: 793  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852

Query: 3232 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKT 3289
             Q+L   +  Q      LQ +Q  + +L   + + + K+ S  ++  + + +++  RWK 
Sbjct: 853  EQRLGELQALQSS----LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 908

Query: 3290 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3349
            L+ ++ +   +L+E +    + Q+ +++L  WM + +  +  + P   + +++K Q+++ 
Sbjct: 909  LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 968

Query: 3350 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ 3409
            +LL   +   + ++  +   G+KI   AEP    ++  +L  L+++W+ +  +   R   
Sbjct: 969  RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1028

Query: 3410 LEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN 3469
            L+G         + L  ++EW+T  E+  +  +       +L++ + + K  +++     
Sbjct: 1029 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1088

Query: 3470 KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKI 3528
              +        S+   +    ++ ++ +L+     Y  +  + + + + L++   C  ++
Sbjct: 1089 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1148

Query: 3529 FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLN 3587
                E +   WLNEV  KL        +TE +     E+  VL     L + + D    N
Sbjct: 1149 LSYLE-KANKWLNEVEFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--N 1198

Query: 3588 GLELLKQTTGDEVL---IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA----RRLHS 3640
             + +L QT  D  +   +I ++LE   +R++++ + +    K LEQ++Q A    + LH 
Sbjct: 1199 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1258

Query: 3641 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSAL 3700
              E L T++DK   +L +Y   +    +A+Q     ++++ +  +++  L+ + + +   
Sbjct: 1259 IQESL-TFIDK---QLAAY---IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN--- 1308

Query: 3701 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ---FDQAADAELSW 3757
                  + +E  ++++++         D   +K++++       Q+   F+Q        
Sbjct: 1309 ------QGKEAAQRVLSQ--------IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1354

Query: 3758 ITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEE 3817
            + E +  L +L    +EQ+   +QL         +   K  ++ ++K+G +I+     E 
Sbjct: 1355 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1414

Query: 3818 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3877
             + + +++  +  +Y+ +    +ER  QLE+   L  +  +    L  WL  T   +++ 
Sbjct: 1415 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1474

Query: 3878 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3937
             A       L  +    +  ++ I + K H+  + + G  L  +   +   +++K     
Sbjct: 1475 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL---- 1530

Query: 3938 TLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE 3997
            +L +     V  RA   +E ++   ++   ++   ++++ I + + Q  ++  E EK K 
Sbjct: 1531 SLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1587

Query: 3998 QISEN--KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4055
            Q  E+  K +  ++  ++P  ++ + +   ++A  G    D   K V+ ++ ++   +  
Sbjct: 1588 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELNHRFAA 1643

Query: 4056 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4115
            I   ++  +A +   ++  E+F  D   L+  ++       +L++   +  + +  +   
Sbjct: 1644 ISHRIKTGKASI--PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 1701

Query: 4116 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4175
            + + +  D LQ+ +               E  +  +K     L +  ++L      R  K
Sbjct: 1702 KELLQRGDNLQQRI-------------TDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1748

Query: 4176 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ 4235
              E      QY+     +   +D    KLAS+ P   D   +K+   EL++ K       
Sbjct: 1749 ALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQKKKE------ 1801

Query: 4236 IEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN-------RQHKL-E 4287
             E+  +  QAE L    +E+     V+   ++L   W  +E +          + H + E
Sbjct: 1802 -ELNAVRRQAEGL----SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE 1856

Query: 4288 GALLALG-----QFQHALDELLAWLTHTEGLLSEQKPVGGDP----KAIEIELAKHHVLQ 4338
              ++ +      +  +     L  +TH    L E + +   P    K  E    +   L+
Sbjct: 1857 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 1916

Query: 4339 N--DVLAHQS-TVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4395
            N  D L   S  ++ ++      ++S+   E   LQ  L  L+ +W+ V +  + R+ + 
Sbjct: 1917 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 1976

Query: 4396 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET---AKEQLNVHMEVCAAFEA 4452
            D ++ + + FH +I+   QWLT+ E+ L  ++    +PE    AK +  +  E+      
Sbjct: 1977 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYL-KELQDGIGQ 2031

Query: 4453 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4512
            ++   ++L   G++++ +  K+  + + + + +L  +W+ V  +L++RK +LEE  N+  
Sbjct: 2032 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2091

Query: 4513 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4572
            EF   L +F+ WL +A+   ++   P      +  ++++ K+   E+   +  + +L++T
Sbjct: 2092 EFQRDLNEFVLWLEEADNIASIPLEPGK-EQQLKEKLEQVKLLVEELPLRQGILKQLNET 2150

Query: 4573 G----THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERG-------RSLDDARKRAK 4621
            G           ++QD   ++N L     +W KV + L E+        + L    K+ +
Sbjct: 2151 GGPVLVSAPISPEEQD--KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2208

Query: 4622 QFHEAWSKLMEWLEESEKSLDSELEIANDP------DKIKTQL---AQHKEFQKSLGAKH 4672
               E  + L+ WL      + ++LEI N P      D  +T++   A+  + ++ L    
Sbjct: 2209 DLEEQLNHLLLWL----SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2264

Query: 4673 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD------TICGKS---------- 4716
             +Y     T    ++   L+ +   ++ +L ELR K        T  G S          
Sbjct: 2265 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 2324

Query: 4717 -----------VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4765
                       +E  + L   +     F  A   L DWL  ++  +   + + GD++ + 
Sbjct: 2325 PVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDIN 2384

Query: 4766 NLIDNHKAFQKELGKRTSSVQALKRSARELIE--GSRDDSSWVKVQMQELSTRWETVCAL 4823
             +I   KA  ++L +R   ++ L  +A+ L     +++  + +  +++ +  +W+ V   
Sbjct: 2385 EMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEH 2444

Query: 4824 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4883
              +++ +L   L+ + ++        + L +A   L      P   DA++  I + K+  
Sbjct: 2445 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2504

Query: 4884 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4943
            K L + +  ++ A  +   +L     D    + H IT      E + A  +   +R++  
Sbjct: 2505 KDLRQWQTNVDVANDLALKLLRDYSADDTRKV-HMIT------ENINASWRSIHKRVSER 2557

Query: 4944 LAGLIAKQEL-------LEALLAWLQWAETT---LTDKD-KEVIPQEIEEVKALIAEHQT 4992
             A L     L       LE  LAWL  AETT   L D   KE + ++ + VK L+ + Q 
Sbjct: 2558 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 2617

Query: 4993 FMEEM 4997
               E+
Sbjct: 2618 LQGEI 2622



 Score =  277 bits (708), Expect = 2e-73
 Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)

Query: 2077 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2136
            Q  L+E+L W+ + E +L+ QG++  +   ++D    +     D+   Q  +  + +   
Sbjct: 222  QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 281

Query: 2137 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2194
            K + T   S    + +Q +M  L++R+        E  + +   +  ++L     ++L  
Sbjct: 282  KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 339

Query: 2195 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2248
            +L TKT+  T   E +  G D+ +L + +Q+       HK   + LE     +  ++   
Sbjct: 340  WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 391

Query: 2249 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2301
            +  D++     T  L ++ K + D      +  ++     Q+ L  +Q L +      +W
Sbjct: 392  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 451

Query: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2347
            + E    V  +  + G +D  + L   +KL               + +SLK   +  + N
Sbjct: 452  LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 510

Query: 2348 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397
              ++      L N      + V    K+ A +    AV   + + T T        +T+ 
Sbjct: 511  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 567

Query: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457
             ++   + H  E+L      K  ++       ++   + + +  W+ +         Q+P
Sbjct: 568  -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 622

Query: 2458 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2513
              A    E   + +++   + E E  +   K+Q+       L+E+  +    A   KQ  
Sbjct: 623  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 682

Query: 2514 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2573
             +++S+W E  QL  +R   LE   NN+  F     QL+Q     E  + +      +P 
Sbjct: 683  EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 741

Query: 2574 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2633
             + +Q +  +  +   +  +PQ E+L       L   G+ P     +     A T  +  
Sbjct: 742  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 797

Query: 2634 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2691
            +   +  R   +      +   +YQ  + ++   +   + KLS      T  + M Q+L 
Sbjct: 798  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 857

Query: 2692 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2751
              Q ++  +Q+++  +       +++S     E +  +   + E I   +K +  +   H
Sbjct: 858  ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 916

Query: 2752 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2811
             Q L+       + Q   +  + W+        +  P     ++L+  +K  +     + 
Sbjct: 917  CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 976

Query: 2812 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2871
                        G+ +  + +    + L+ +L  + T WD   +QV  R+  LK  LEK 
Sbjct: 977  TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1036

Query: 2872 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2930
            +  ++ +  +  W+ + +    E  F    P E + ++ ++K  ++E  Q    V+LL  
Sbjct: 1037 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1096

Query: 2931 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 2989
            + NS+++    + +E +  E ++L      +  +L+ K   LE +   + E     +++ 
Sbjct: 1097 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1156

Query: 2990 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3048
            + L   + +L   +++ G     ++ L  L+   +  +   +Q+ +   LAQ L      
Sbjct: 1157 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1208

Query: 3049 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3106
              G  D L+  ++ET       L ++   +   LE  +Q     + ++  +       D 
Sbjct: 1209 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1268

Query: 3107 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3166
            +L +      DA  + ++ + I++ L   E                ++ EE      G +
Sbjct: 1269 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1312

Query: 3167 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3223
                 LS+     +D AQ + + V    +  ++   F  +L+E  ++L + + H  +   
Sbjct: 1313 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1367

Query: 3224 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3283
              +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +
Sbjct: 1368 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1425

Query: 3284 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3343
               +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + 
Sbjct: 1426 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1485

Query: 3344 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3403
            +++   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++A
Sbjct: 1486 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1544

Query: 3404 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3463
            E     L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +
Sbjct: 1545 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1602

Query: 3464 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3515
            DI              Q+  ++++R D  + +V+ ++      F+ + + I+  + S   
Sbjct: 1603 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1657

Query: 3516 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3569
             EL Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+
Sbjct: 1658 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1715

Query: 3570 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
              E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K
Sbjct: 1716 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1775

Query: 3627 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3683
             L    +    R++     EL     K E+  +  + + L  + A+ A +    +L K  
Sbjct: 1776 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1833

Query: 3684 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3742
            +  ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L
Sbjct: 1834 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 1889

Query: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3802
              +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +
Sbjct: 1890 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 1949

Query: 3803 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3862
                 K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ       
Sbjct: 1950 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 1995

Query: 3863 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3922
               WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S
Sbjct: 1996 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2050

Query: 3923 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981
                 SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + 
Sbjct: 2051 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2109

Query: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041
            +   P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     
Sbjct: 2110 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2167

Query: 4042 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4092
            +++KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   +
Sbjct: 2168 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2225

Query: 4093 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4152
            + +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK
Sbjct: 2226 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2277

Query: 4153 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4177
            + +++L+S W ++N+  ++                                    I KLE
Sbjct: 2278 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2337

Query: 4178 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4231
                    + A   +      + DW+ +    + S   +  DLE + + I + K    + 
Sbjct: 2338 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2397

Query: 4232 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4291
             Q++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L 
Sbjct: 2398 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2457

Query: 4292 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
               Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  
Sbjct: 2458 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2517

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
            N     L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E 
Sbjct: 2518 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2577

Query: 4412 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4465
               WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q
Sbjct: 2578 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2637

Query: 4466 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4524
            ++L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + W
Sbjct: 2638 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2697

Query: 4525 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4584
            L   +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q 
Sbjct: 2698 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2754

Query: 4585 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4635
            +  ++ L      +  + R + V + L          RK+A++ +  W KL     +W  
Sbjct: 2755 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2804

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQ 4660
            + +++L+   E+    D++  +L Q
Sbjct: 2805 KIDETLERLQELQEATDELDLKLRQ 2829



 Score =  226 bits (576), Expect = 5e-58
 Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)

Query: 3299 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3358
            + L E+ ++  R+Q ALE +LSW++  E+ +  Q   S + +VVK Q    +     L  
Sbjct: 209  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 268

Query: 3359 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3416
             +  V  I + G K+  T + +  ++ ++ +Q++LL+SRWE L   +  +   L  + + 
Sbjct: 269  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 328

Query: 3417 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3470
             Q  ++ L+ LN+WLT  E+R   +  EP+G     L+ Q+ QHK L++D+    +  N 
Sbjct: 329  LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 386

Query: 3471 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3530
              H  V + +S    S       ++ +L      +  I   +  R  LLQ  L   +   
Sbjct: 387  LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 442

Query: 3531 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3590
            E++     WL+E  D ++K+      T G   Q   L  LQ+  +L+           LE
Sbjct: 443  EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 488

Query: 3591 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3650
              KQ+ G    + QD L  +K +                          S  ++   WLD
Sbjct: 489  KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 522

Query: 3651 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3710
                    ++  V K E+++    +     + +     +++++  V++    LV   A+E
Sbjct: 523  NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 578

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
             L        ++ ++  D+  +K  ++D   L             SWIT +E  L S   
Sbjct: 579  ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 624

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3826
                ++   + L+ +K   +E  + +    + D  +S   ++     E     S+K+  +
Sbjct: 625  AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 683

Query: 3827 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3886
            ++   +   CQ+ SER   LE   +++  F+   ++L    T  ++ +   P    E   
Sbjct: 684  QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 742

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946
            ++ Q +  +     ++  +P I+++      L E   G  F +   +VA    + Q+  D
Sbjct: 743  IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 801

Query: 3947 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4004
            V+ R   L          ++ + +  I   +++   +L  P     + E +++++ E + 
Sbjct: 802  VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 861

Query: 4005 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            +   +++ Q     L    +EM   S     +IS K  Q + +++   W+ + + + E  
Sbjct: 862  LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 917

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4123
             KL + M    K      +L   + +   F+++ E P + D  ++K+Q +    +  +I 
Sbjct: 918  QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 976

Query: 4124 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4182
             +Q  L+ V N G + I    EP+    ++  + ELN+ WD + +    R + L+  ++ 
Sbjct: 977  TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1035

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
             V  Q  L  + +W+  A  +           + +++ +EE+K+ K EA Q++ +++ L 
Sbjct: 1036 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1095

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4302
                 ++ +    + +  ++  L  L   +  L  R+  +   LE       +    L++
Sbjct: 1096 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1154

Query: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4362
               WL   E  L   + + G  + I   L     L+N +   +     +      L +  
Sbjct: 1155 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1211

Query: 4363 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4422
              +E  N   +LE  N RW+ + E+  +R++ L+ +++ A+     +  +Q+ LT  ++ 
Sbjct: 1212 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1269

Query: 4423 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4478
            L A          +P+ A++   +  ++ +   + EE     M+K  Q      K A   
Sbjct: 1270 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1316

Query: 4479 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4538
            +   I+  ++K + V  K                 F   LQ+    L + +  L      
Sbjct: 1317 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1368

Query: 4539 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4598
            S+  + V  Q++        ++  + ++  + KTG  +    Q ++   +   + +++  
Sbjct: 1369 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1428

Query: 4599 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4658
            + ++  ++ ER + L+   K +++  +  + L EWL  ++  L     +   P  + +++
Sbjct: 1429 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1488

Query: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4718
            A  K  QK +  +     +    G +L  KT L      ++D LS L   W  +  ++ E
Sbjct: 1489 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1546

Query: 4719 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4778
              N L E       F   +  +  W+ + +  L E +             D  K  + EL
Sbjct: 1547 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1601

Query: 4779 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837
                  V + +  A  L+    D     V+ Q+ EL+ R+  +      K  +    L++
Sbjct: 1602 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1659

Query: 4838 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4896
             E+F+S +  LLE L AE +Q     GV   +ED  + + + ++  +K+L ++   L + 
Sbjct: 1660 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1714

Query: 4897 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4954
             T                          R  E +   +Q  Q   +AL  L +  +++ L
Sbjct: 1715 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1750

Query: 4955 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5004
            E    W Q+          L D +K++     P++  ++K +  E Q   EE+   +   
Sbjct: 1751 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1810

Query: 5005 DKVTKTYKRRAADPSSLQ 5022
            + +++     A +P+ +Q
Sbjct: 1811 EGLSEDGAAMAVEPTQIQ 1828



 Score =  205 bits (521), Expect = 1e-51
 Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)

Query: 3466 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3525
            ++H  H  Q +++  +     +   K   +S   ++Q  Y+   + + S           
Sbjct: 145  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 203

Query: 3526 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3572
             K FG    E EV L  +   + + LS L   + + +   +  +++ V+++         
Sbjct: 204  DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 263

Query: 3573 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3629
             D+   +  V   L  G +L+   + + DE   +Q+++  + +R++ +   S +    L 
Sbjct: 264  MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 323

Query: 3630 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3687
            + L   +  +   +EL  WL K E      E + L    E+  +   + K L+++ +  +
Sbjct: 324  RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 381

Query: 3688 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3747
              ++SL  +   + E     A   LE+ +    +R+  +      +   +   +L+ Q+ 
Sbjct: 382  VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 441

Query: 3748 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3807
             +      +W++E E                     V K  T       +++  L K   
Sbjct: 442  TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 481

Query: 3808 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3867
             ++ A  E++KQSM K     LK  D +  + ++   Q  + ++ ++ F   ++ L   L
Sbjct: 482  -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 535

Query: 3868 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
             ++ + ISQ      P+L   T+ +         +++ +H    +++    PQ       
Sbjct: 536  EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 586

Query: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984
                 +++ +  D+       +++KR   LD  I++   +  + + +L+S E  + R   
Sbjct: 587  -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 630

Query: 3985 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
                      +KE+++  +    +   KLQ    + +   E+M+      ++ ++A +++
Sbjct: 631  -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 679

Query: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4103
               +Q+   W     L+ ER    L+       F+     L       +++++       
Sbjct: 680  QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 738

Query: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4163
            +P+ +K Q +  +     + GLQ +++    L  + IA   +   P+    +D    A+ 
Sbjct: 739  EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 792

Query: 4164 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4217
            +  K     +   E+ +Q        ++YQ+ + A+  WV  +  KL+      TD E +
Sbjct: 793  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 852

Query: 4218 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4277
            +Q++ EL+  +S   +QQ  +  L+   + + KK   E  +   Q    E++  W  L  
Sbjct: 853  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 911

Query: 4278 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4337
            +++    KLE  +  L + Q+ +  L  W+   +  L E+ P  GD + ++ +L +  +L
Sbjct: 912  QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 971

Query: 4338 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4397
             +D+   Q ++ +VN+ G  +   +  E AS L+ +L+ LN +W ++ ++   RK+ L G
Sbjct: 972  VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1031

Query: 4398 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4457
             L +      ++ ++ +W+T  E   L        P+  ++ +          + KE   
Sbjct: 1032 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1091

Query: 4458 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4517
            K L +    ++A+ P  A+  + +++  L   ++ + T+LN +   LEE      E  + 
Sbjct: 1092 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1151

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
            L+    WL + E  L          + +   +D  +        +  QI  L +T T   
Sbjct: 1152 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1211

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637
               +     LI   L +  SRW ++ +  V R + L+ + + A++  ++   + E L   
Sbjct: 1212 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1266

Query: 4638 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4686
            +K L + +       ++  +  KI++ L  H    +E +K    K +     ++   + K
Sbjct: 1267 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1326

Query: 4687 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4746
                      KL D+  + R     +  K    + +L+E+ +   +    L AL      
Sbjct: 1327 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1365

Query: 4747 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4805
             E +  E + V   ++  +NL        K L +  S V+ + ++ R++++  + ++   
Sbjct: 1366 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1417

Query: 4806 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4865
            +  ++  L   +  + A    ++ +LE  L+ + +    ++ L EWLA  +  L     +
Sbjct: 1418 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1477

Query: 4866 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925
                  L + +   K   K++E+++  L   T +G+ +  +      T ++  ++++ + 
Sbjct: 1478 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1536

Query: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985
            +  V + A++    L      +    + ++ +  W+  A+T L + +K+   Q+ + +K 
Sbjct: 1537 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1596

Query: 4986 LIAE 4989
            L AE
Sbjct: 1597 LKAE 1600



 Score =  184 bits (467), Expect = 2e-45
 Identities = 494/2698 (18%), Positives = 1056/2698 (39%), Gaps = 384/2698 (14%)

Query: 1170 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1229
            KLK +N  L  T+          T+  EEE +  D  +++  +   K  + ++++++   
Sbjct: 333  KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 384

Query: 1230 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1289
            ++L   +     + DE    +    L+     E+   L +RW N+    ++R   L+ I 
Sbjct: 385  NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 434

Query: 1290 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1347
              LK+ R T        W+ + E    KI     ++   + + L +  +L +++E K+  
Sbjct: 435  -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 493

Query: 1348 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401
            M +     +   +T+K+  +   T      +    D+  +   K     S A    Q  +
Sbjct: 494  MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 553

Query: 1402 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1454
               T    + T+ T+    +K A + L     ++K   +++ E ++ ++    EL  W++
Sbjct: 554  TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 613

Query: 1455 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1504
                 L+  E     K G     K+K+++   E + K  +L +A ++ Q  + +  +   
Sbjct: 614  RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 673

Query: 1505 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1547
                 K   E+ N         L +++  L+   N++ F   L+QL++  T+ +  +K+ 
Sbjct: 674  NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 733

Query: 1548 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1594
                 E   +  + +  K+++  +  L  Q E   I        G    F+  D      
Sbjct: 734  PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 793

Query: 1595 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1639
             +       Q++++ELQ           Q +  A+   V+ +E   K +  +LS  D  +
Sbjct: 794  HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 851

Query: 1640 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1699
            +EQ+L E  ++  Q +L+ +QS       ++T +KE ++K  +     E   K ++  + 
Sbjct: 852  MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 901

Query: 1700 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1759
            +    K       +H Q +E+     Q    +        +   + E DV  +       
Sbjct: 902  IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 956

Query: 1760 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1819
             ++  +K   Q   ++S  Q +  +  S     +K      PE   +L+  +KEL   ++
Sbjct: 957  DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1016

Query: 1820 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1879
                +   + +      E+      D +E   W+ Q+E+E    +      + L   ++ 
Sbjct: 1017 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1076

Query: 1880 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1939
             K   E+    +  ++ +T S N V+  A   ++              ++++L+  T  +
Sbjct: 1077 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1124

Query: 1940 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1999
            + L   C  L    K L + +  + +    LL+ L+     A+K L+E        ++ +
Sbjct: 1125 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1165

Query: 2000 LEETKALQG---QISSQQVAVEKLKKTAEVLLDARGSLLPAKND-------IQKTLDDIV 2049
            L+ T+ + G   +IS    ++E L + +E   +    L     D       I + L+   
Sbjct: 1166 LKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFN 1225

Query: 2050 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-------EQGQVPL 2102
             R+ +L +    R + L+ ++  +   +  L  + + +  ++  L        +  Q+P 
Sbjct: 1226 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQ 1285

Query: 2103 NSTALQ-DIISKNIMLEQ---DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2158
             +  +Q D+ S  I LE+      G++++   +++      +  D S    L  K  +  
Sbjct: 1286 EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE 1345

Query: 2159 ARFSEASHKHKETLAKMEELKTK--------------VELFENLSE---KLQTFLETKTQ 2201
             R  E+     E    +  L+TK              V L+++LSE   +++  ++T  Q
Sbjct: 1346 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 1405

Query: 2202 ALTEVDVP-------------------GKDVTELSQYMQESTSEFLEHKKHLEVL----- 2237
             + +                       G  VTE  Q +++      + +K + VL     
Sbjct: 1406 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1465

Query: 2238 ---HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL 2294
                 L K  +  G+PS+    +       K+ ++ +  +K   E   + +  L   + L
Sbjct: 1466 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1525

Query: 2295 VKSLKS-----WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2349
            V+   S     WI  T++          AE+    L + +K  E +      I K     
Sbjct: 1526 VEDKLSLLNSNWIAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1575

Query: 2350 ISLCNLISAVTTPAKAIAAVKSGGAVLNG-----EGTATNTEEFWANKGLTSIKKDMTDI 2404
             +L +  S    P +    +K   A LN      + T        AN+G           
Sbjct: 1576 DTLLD-ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----------- 1623

Query: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2464
                +    L++ +I+ELN + + +    +   A +  L+++ +  +  Q+   P + E 
Sbjct: 1624 ----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLEPLEAEI 1678

Query: 2465 VKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2523
             +    + + F  ++ + N   V+EL  +   L +   D  +    K     + +K   L
Sbjct: 1679 QQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1738

Query: 2524 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2583
              L   R++K  E S+   Q++     L + L + E  ++ L P   D   +    +++Q
Sbjct: 1739 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQ 1797

Query: 2584 ILLQEFATRKPQYEQLTAAGQGILSRP-------------GEDPSLRGIVKEQLAAVTQK 2630
               +E    + Q E L+  G  +   P              +    R +   Q+  V ++
Sbjct: 1798 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1857

Query: 2631 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2690
                T  +      ++ + V ST Y + +  +S  L +++  L++    +   + + +Q 
Sbjct: 1858 ----TMMVMTEDMPLEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 1912

Query: 2691 ETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQLEGILKSFK 2742
            E+ + +K  +QQ   +I +  +  +  +AL        VK +   ++L  Q E + K +K
Sbjct: 1913 ESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 1970

Query: 2743 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH-PISAKLDVLESLIK 2801
            D + + +  V+  +        F Q   + + +L   +  +N  H      L  L+  I 
Sbjct: 1971 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2030

Query: 2802 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERE 2861
              +   +TL           A GE ++ ++  ++ + LQ +L ++   W    KQ+ +R+
Sbjct: 2031 QRQTVVRTLN----------ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2080

Query: 2862 NKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE---NSIAKLKSLQKEM 2918
             +L+E      +++  +     W+++  +N+  I   L+P + +     + ++K L +E+
Sbjct: 2081 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLEQVKLLVEEL 2137

Query: 2919 DQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK-------------------------- 2951
                G+++ LN T   +L    I  E     ENK                          
Sbjct: 2138 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2197

Query: 2952 ----SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-----SKRQLQCAKEQLDIH 3002
                 L +K++ + EQL+     L  +  + + + + ++E      + ++    +Q D+ 
Sbjct: 2198 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2257

Query: 3003 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD---------SKGTS 3053
            + L    +  K     Q  ++ L+ L  +     RL Q+L  +  D         +  T 
Sbjct: 2258 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2317

Query: 3054 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3113
             V L  + +  + + +S+   E  S L  ++  +  F     E+    +  D  + S   
Sbjct: 2318 TVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2375

Query: 3114 VGRDAETLQ----KQKETIKAFLKK---LEALMASNDN-ANKTCKMMLATEETSPDLVGI 3165
            +  D E +     KQK T++   ++   LE L+ +  N  NKT      T  T       
Sbjct: 2376 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD------ 2429

Query: 3166 KRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVG 3225
               +E +  Q +++ +  Q R +Q+   +K   ++    +E   +L +A    ES     
Sbjct: 2430 --RIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2487

Query: 3226 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3285
               + I +++   K   K ++   Q      N L   L++  + +  T+ +    +++NA
Sbjct: 2488 YTVDAIQKKITETKQLAK-DLRQWQTNVDVANDLALKLLRDYS-ADDTRKVHMITENINA 2545

Query: 3286 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----ANQKPPSAE-F 3339
             W++++K+V++R A L+E      +F   LE  L+W+ + E        A +K    E  
Sbjct: 2546 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2605

Query: 3340 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEA 3398
            K VK  +++ + LQ  ++        +    +KI  + E +D   +L ++L  ++ +W  
Sbjct: 2606 KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 2665

Query: 3399 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3458
            L  K+      LE  S   ++ H +L+ L  WL   +  L    PIG     +++Q   H
Sbjct: 2666 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 2725

Query: 3459 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3518
            +A + ++      +   +S  +++++  + +  + ++    + +   +  +E++ + + L
Sbjct: 2726 RAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPEERAQNVTRL 2780

Query: 3519 LQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3577
            L++         E   +   +W  ++ + L +L     +T+ L     +L++ Q +++  
Sbjct: 2781 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKG 2835

Query: 3578 K-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3634
              Q V   L++ L              QD LE +KA   +I  L  +V+   + A QL
Sbjct: 2836 SWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHVNDLARQL 2879



 Score =  104 bits (259), Expect = 3e-21
 Identities = 49/110 (44%), Positives = 73/110 (66%), Gaps = 2/110 (1%)

Query: 149 EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV-QS 207
           +  ++++ LL W +Q+T  Y  +   NFTT W DG   NA+IH +RPDL D N+V   QS
Sbjct: 9   QQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQS 68

Query: 208 NLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 256
               LEHAF +A  ++G+ +LLDPEDVD + PD+KS++ Y++SL+   P+
Sbjct: 69  ATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 118



 Score = 38.9 bits (89), Expect = 0.14
 Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)

Query: 608  VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666
            +Q+LL W+     +L R    G D P+V+       +VHRA +  E   KE  I     T
Sbjct: 2691 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2745

Query: 667  APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 726
              + LT  + L  LE  Y         + R L        RA N +  L  K+ EEV  +
Sbjct: 2746 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2791

Query: 727  WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 774
            W + N        + A+  R++D+  E ++ +QE  ++L L+   A +
Sbjct: 2792 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2832


>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
          Length = 3685

 Score =  325 bits (832), Expect = 1e-87
 Identities = 545/2835 (19%), Positives = 1126/2835 (39%), Gaps = 316/2835 (11%)

Query: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-----------EVLH 2238
            ++ QT LE     L   +   +   E+S  ++    +F  H+ ++            +L 
Sbjct: 342  DRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQ 401

Query: 2239 SLLKEISSHGLPSDKAL-VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297
               K I +  L  D+   V E+ N L+ +++ +     EK+  +   +  +D     +K 
Sbjct: 402  LGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKE 459

Query: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
            L  W+ +T ++   ++     E LG  LED K+  ++  +   ++++      SL +++ 
Sbjct: 460  LNDWLTKTEERTRKMEE----EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVV 515

Query: 2358 AVTTPA--KAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLL 2415
             V   +   A AA++    VL            WAN            I    ED  +LL
Sbjct: 516  VVDESSGDHATAALEEQLKVLGDR---------WAN------------ICRWTEDRWVLL 554

Query: 2416 KDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSF 2475
            +D        L K Q+  EE      WL +      K   T      E + + +++    
Sbjct: 555  QDI-------LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS-LQKLAVL 606

Query: 2476 EAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEI-DSKWQELNQLTIDRQ 2531
            +A+L   KQ++ K+  LK  L   L+    T +   W        D+  Q+L + T    
Sbjct: 607  KADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQIS 666

Query: 2532 QKLEESSNNLTQFQTVEA------------------------------------------ 2549
            Q +  +  +LTQ   +E                                           
Sbjct: 667  QAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV 726

Query: 2550 ---QLKQWLVEKELMV-SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605
               +L  W+   E ++ S    +       +  +++V  + +E A +  + +  + + Q 
Sbjct: 727  DITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQA 786

Query: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665
            ++ +   +      +K+    +  +W      LS+R +W++        + + L+ L   
Sbjct: 787  LVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQN-NIIAFYNQLQQLEQM 845

Query: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEE- 2724
             +  +N L       + P A+  QL+  +     +   + QI+  +      S  +KE+ 
Sbjct: 846  TTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQ----SIALKEKG 901

Query: 2725 ----YLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2780
                +L A+         + F DV+ + E  +Q +        ++Q+     + W+   +
Sbjct: 902  QGPMFLDADFVAFTNHFKQVFSDVQAR-EKELQTIFDTLPPM-RYQETMSAIRTWVQQSE 959

Query: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840
             + +         +++E  + + +    +L  Q           + +  K         Q
Sbjct: 960  TKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQ 1019

Query: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
             +   I+  W   + Q+ E   KL+E + K  K +  ++TL  W+ +    L+E      
Sbjct: 1020 SEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW---- 1075

Query: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTD-----------E 2949
            PA G++ I     L+K++ Q   +V  +     SL SV E  +++  +           E
Sbjct: 1076 PALGDSEI-----LKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETE 1130

Query: 2950 NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA 3009
             K L  + D + +Q++++K  L+   +K    Q+   E    +  A+E+    D      
Sbjct: 1131 LKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERD------ 1184

Query: 3010 YSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTL 3069
            +  K    LQ   + ++  K +    K     L+ E+ +S       +  E + +E  TL
Sbjct: 1185 FEYKTPDELQKAVEEMKRAKEEAQ-QKEAKVKLLTESVNSVIAQAPPVAQEALKKELETL 1243

Query: 3070 SQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIK 3129
            +      C+ L  K + +        E+ S   + +  L+ +    +  E +    E I 
Sbjct: 1244 TTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEIS 1303

Query: 3130 AFLKKLEALMA-SNDNANKTCKMMLATEETSPDLVG--IKRDLEALSKQCNKLLDRAQAR 3186
              L  LE LM  S DN N+    +LA   T   ++   I  +LE  + +  +L + A  R
Sbjct: 1304 EVLDSLENLMRHSEDNPNQI--RILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRR 1361

Query: 3187 EEQVEGTIKRLEEFYSKL---KEFSILLQK------AEEHEESQGPVGMETETINQQLNM 3237
            ++ +E +I+  +E    L   +E    + K      A++ + +Q P   E + I   L  
Sbjct: 1362 QKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMP--QEAQKIQSDLTS 1419

Query: 3238 FKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQR 3297
             ++  +E  +  QGK+     L Q  I  A K          L DV+ +++ L +K A  
Sbjct: 1420 HEISLEEMKKHNQGKEAAQRVLSQ--IDVAQKK---------LQDVSMKFR-LFQKPANF 1467

Query: 3298 AAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLD 3357
              +LQE+ +     +  L +L              +  S E +VV++Q+     L + L 
Sbjct: 1468 EQRLQESKMILDEVKMHLPAL--------------ETKSVEQEVVQSQLNHCVNLYKSLS 1513

Query: 3358 DRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVA 3417
            + KS VE++ + G +I    +  +  ++ ++++ L   +  L  K   R +QLE    ++
Sbjct: 1514 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1573

Query: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3477
            ++  + +  L EWL   +  L     +    S L+ ++A  KA + +I     HL     
Sbjct: 1574 RKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITE 1633

Query: 3478 IGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELM 3537
            +G++LK +  +++  +V+ KL      +I +  ++     LL +   + + F ++   + 
Sbjct: 1634 VGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHIT 1692

Query: 3538 NWLNEVHDKL--SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQT 3595
             W+ +    L  S+        + L + ++EL  ++  +   +      + N  +  ++ 
Sbjct: 1693 KWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKL 1752

Query: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655
               ++  +  +  AI  R K  T  ++   K LEQ     ++L          L+ +E E
Sbjct: 1753 VEPQISELNHRFAAISHRIK--TGKASIPLKELEQFNSDIQKL----------LEPLEAE 1800

Query: 3656 LLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKM 3715
            +   +   LK E+ +      K++ ++  N   + + L    +    +   R RE ++  
Sbjct: 1801 I--QQGVNLKEEDFN------KDMNED--NEGTVKELLQRGDNLQQRITDERKREEIKIK 1850

Query: 3716 VAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQ 3775
                  ++  + D  +Q+ ++      +  Q+ + AD  L  + + EKKL SL + R E+
Sbjct: 1851 QQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDER 1910

Query: 3776 D--QTSAQLQVQKTFTMEILRHKDII--DDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831
               +   +LQ +K     + R  + +  D    +        S+  ++   K       N
Sbjct: 1911 KIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLN 1970

Query: 3832 YDTICQINSERYLQLERAQSL-VNQFWETY----EELWPWLTETQSIISQLPAPALEYET 3886
            +  I  +  E  + +     L ++    TY      +   L E + +++     A ++E 
Sbjct: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFED 2030

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMN-KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKE 3945
            L +Q+E  + +++ + +    ID ++ K    L   +P E   +QE     D  + ++ +
Sbjct: 2031 LFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNK 2090

Query: 3946 DVKKRAVALDEAISQSTQFHDKI---DQILESLERIVERLRQPPSISAEVEKIKEQISEN 4002
              K R    D ++ +  +FH  I   +Q L   E+ + + + P +   E  K K  + E 
Sbjct: 2091 MYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENW--EHAKYKWYLKEL 2148

Query: 4003 KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEE 4062
            ++    + + Q +  TL   GEE+I +S  TD  I    +Q+KL  +   W+ +   + +
Sbjct: 2149 QD---GIGQRQTVVRTLNATGEEIIQQSSKTDASI----LQEKLGSLNLRWQEVCKQLSD 2201

Query: 4063 REAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEI 4122
            R+ +L +   +  +F  D    ++ +++  +      +PG +  + K++ E  + + EE+
Sbjct: 2202 RKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQL-KEKLEQVKLLVEEL 2260

Query: 4123 DGLQEELDIVINLGSELIAACG----EPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEE 4178
               Q  L  +   G  ++ +      E DK  ++  + + N  W  +++A  ++  ++E 
Sbjct: 2261 PLRQGILKQLNETGGPVLVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEA 2318

Query: 4179 AMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE----LKQFKSEAYQQ 4234
             ++   Q +  L+   D  +     L  +SPI   LE   Q  +E    +++ +     +
Sbjct: 2319 QIKDLGQLEKKLE---DLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAK 2375

Query: 4235 QIEMERLNHQAELLLK-KVTEESDKHTVQDPLMELKLIWDSLEER--------------- 4278
            Q ++E +  + + L K K   +  K  ++D   E K +   L+E                
Sbjct: 2376 QPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIG 2435

Query: 4279 -------------IINRQ---HKLE--GALL----ALGQFQHALDELLAWLTHTEGLLSE 4316
                         ++ ++    KLE   +L+    AL  F  A  EL  WL+  + ++  
Sbjct: 2436 ASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKS 2495

Query: 4317 QKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNL-QNKLE 4375
            Q+ + GD + I   + K      D+   +  +E +  A  +L   ++ +EA  +  +++E
Sbjct: 2496 QRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIE 2555

Query: 4376 VLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
             +  +W  V E  + R+QQL+  L+ +  +    E+ +Q L      L + K      + 
Sbjct: 2556 RIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA 2615

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVET 4495
             ++++    ++       +           ++L          +     N+   W S+  
Sbjct: 2616 IQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHK 2675

Query: 4496 KLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV---ASRPSLILDT---VLFQI 4549
            +++ER+  LEE   L  +F   L+ F+ WLT+AE T NV   A+R   +L+    V   +
Sbjct: 2676 RVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELM 2735

Query: 4550 DEHKVFANEVNSHREQIIELDKTGTH-LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4608
             + +    E+ +H +    LD+     L+      D VL++  L ++  +W ++ ++ + 
Sbjct: 2736 KQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLN 2795

Query: 4609 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4668
                L+ +  + K+ H +  +L+ WL+  +  L  +  I  D   ++ Q   H+ F++ L
Sbjct: 2796 IRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKREL 2855

Query: 4669 GAKHSVYDTTNRT-------------------GRSLKEKTSLADDNLKLDDMLSELRDKW 4709
              K  V  +T  T                    R L  +    +    L     E+  +W
Sbjct: 2856 KTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEW 2915

Query: 4710 DTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD--IDLVMNL 4767
            + +   S + Q K++E L    +  +A   L   L + E      QPV GD  ID + + 
Sbjct: 2916 EKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDH 2974

Query: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
            ++  KA + E+     +V  +   AR+L       S +    +++L+TRW+ +       
Sbjct: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLL------- 3027

Query: 4828 QTRLEAALRQAEEFH 4842
            Q  +E  +RQ  E H
Sbjct: 3028 QVAVEDRVRQLHEAH 3042



 Score =  316 bits (809), Expect = 5e-85
 Identities = 548/2809 (19%), Positives = 1128/2809 (40%), Gaps = 353/2809 (12%)

Query: 1839 LEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYIT 1898
            L+++     E   WL  +E  L+     ++D+  +  +    + +  D+ +H+G +  I 
Sbjct: 341  LDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL 400

Query: 1899 ISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVD 1958
              G++++   K     +           EVQ +++    R+  L        +NL  ++ 
Sbjct: 401  QLGSKLIGTGKLSEDEE----------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450

Query: 1959 KYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVE 2018
              Q+ +     L   L   E    K   EP+  D ++L+RQ+++ K LQ  +  +QV V 
Sbjct: 451  DLQNQKLKE--LNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN 508

Query: 2019 KLKKTAEVLLDARGSLLPAKNDIQ-KTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQ 2077
             L     V+ ++ G    A  + Q K L D   R+ ++ +   +R   LQ  L +   + 
Sbjct: 509  SLTHMVVVVDESSGDHATAALEEQLKVLGD---RWANICRWTEDRWVLLQDILLKWQRLT 565

Query: 2078 DGLDEMLDWMGNVESSLKEQGQVPLNSTALQD------IISKNIMLEQDIAGRQSSINAM 2131
            +       W+   E ++ +     +++T  +D       + K  +L+ D+  ++ S+  +
Sbjct: 566  EEQCLFSAWLSEKEDAVNK-----IHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKL 620

Query: 2132 NEKVKKFMETT-DPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSE 2190
                +  + T  + S     +A + + +  +     K +++ A++ +  T  +   +L++
Sbjct: 621  YSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQ 678

Query: 2191 KLQTFLETKTQALTEVDVPGKDVTEL-----SQYMQESTSEFLEHKKHLEV----LHSLL 2241
               T +ET T   T   +  K   E       Q  ++ T +  E +K L+V    LHS +
Sbjct: 679  T--TVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDS-EIRKRLDVDITELHSWI 735

Query: 2242 KEISSHGLPSDKALVLEKTNNLS--------------KKFKEMEDTIKEKK--------- 2278
               S   L S +  +  K  N S              +KF++++D  +  +         
Sbjct: 736  TR-SEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNE 794

Query: 2279 ----EAVTSCQEQLDA----FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2330
                +++    EQL++    F  L+    +W++     +         E +  + E+  K
Sbjct: 795  GVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK 854

Query: 2331 LQEKWSLKTPEIQKVNNSGISLC-NLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2389
            +Q      TP       S + +C + ++ ++     I  +K     L  +G         
Sbjct: 855  IQPT----TPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKG--------- 901

Query: 2390 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL--QKAQEESSAMMQWLQKMN 2447
              +G   +  D    ++ ++ +   ++ +  EL T    L   + QE  SA+  W+Q+ +
Sbjct: 902  --QGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQ-S 958

Query: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507
            +T     Q    TD E ++ ++ + ++ ++ L++  + +  L   + E+ ++ P +  + 
Sbjct: 959  ETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAP-SEISR 1016

Query: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567
            +++    EI+ +W++L+   ++  QKLEE  N L + Q     LK+W+ E ++ +    P
Sbjct: 1017 KYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWP 1076

Query: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2627
               D  +L  Q +Q ++L+ +  T +P    +   GQ I +    +P     ++ +L  +
Sbjct: 1077 ALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEA--EPEFASRLETELKEL 1134

Query: 2628 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMN 2687
              +WD +  Q+  R + +   + K+   Q  L  + + ++  + +          PD + 
Sbjct: 1135 NTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQ 1194

Query: 2688 QQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAE--LSRQLEGILKSFKDVE 2745
            + +E  ++ K+E QQ++ ++K+   L E +++++ +    A+  L ++LE +  +++ + 
Sbjct: 1195 KAVEEMKRAKEEAQQKEAKVKL---LTESVNSVIAQAPPVAQEALKKELETLTTNYQWLC 1251

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLD-------TKKEEQNKSHPISAKLDVLES 2798
             +     + L+   A  H+          WL+       T +     +  IS  LD LE+
Sbjct: 1252 TRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLEN 1311

Query: 2799 LIKDHKD-------FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ--------- 2842
            L++  +D        ++TLT    M E    E E    + +   + A++ Q         
Sbjct: 1312 LMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQS 1371

Query: 2843 -------LNTIKTNWDTFNKQVK-------------ERENKLKE-------SLEKALKY- 2874
                   L+ I+ +    +KQ+              +   K++        SLE+  K+ 
Sbjct: 1372 AQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN 1431

Query: 2875 --KEQVETLWPWIDKCQNNLEEI--KFCL--DPAEGENSIAKLKSLQKEMDQHFGMVEL- 2927
              KE  + +   ID  Q  L+++  KF L   PA  E  + + K +  E+  H   +E  
Sbjct: 1432 QGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491

Query: 2928 ----------LNNTANSLLSVCEIDKEV--VTDENKSLIQKVDMVTEQLHSKKFCLENMT 2975
                      LN+  N   S+ E+  EV  V    + ++QK     +Q  + K   E +T
Sbjct: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQK-----KQTENPKELDERVT 1546

Query: 2976 QKFKEFQEVSK---ESKRQLQ-CAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3031
                 + E+     E K+QL+ C K    +   +           M  T++ +++ +   
Sbjct: 1547 ALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSN 1606

Query: 3032 VDL----AKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGI 3087
            +D      K   +++  +    K  ++V   ++T+  +  TL   V++K S L +    +
Sbjct: 1607 LDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL---VEDKLSLLNSNWIAV 1663

Query: 3088 G----HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASND 3143
                  + N + E       FD  +D +      A+TL  + E  K   K+ + L     
Sbjct: 1664 TSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKE-DVLKRLKA 1722

Query: 3144 NANKTCKMMLATEETSPDLVGIKRD--LEALSKQCNKLLDRAQAREEQVEG-----TIKR 3196
              N     + +T + + +L+  + D   + +  Q ++L  R  A   +++       +K 
Sbjct: 1723 ELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKE 1782

Query: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
            LE+F S +++   LL+  E   E Q  V ++ E  N+ +N          E  +G  +++
Sbjct: 1783 LEQFNSDIQK---LLEPLEA--EIQQGVNLKEEDFNKDMN----------EDNEGTVKEL 1827

Query: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
               G  L Q        + ++     +  +   L    +QR  +  E      +++   +
Sbjct: 1828 LQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQAD 1887

Query: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKI--- 3373
             LL  + D E+ +A+   P  E K+        K + R L  +K  +  ++R+ E +   
Sbjct: 1888 DLLKCLDDIEKKLASLPEPRDERKI--------KEIDRELQKKKEELNAVRRQAEGLSED 1939

Query: 3374 --ATTAEPADKVKILKQLSLLDSRWEAL--LNKAE------------TRNRQLEGISVVA 3417
              A   EP  ++++ K+   ++S++     LN A+            T +  LE IS V 
Sbjct: 1940 GAAMAVEPT-QIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLE-ISYVP 1997

Query: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL---HQ 3474
              +   +  +++ L  +E+ L   +        L +Q    K ++D +   +  +   H 
Sbjct: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHS 2057

Query: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEV 3534
              +          R       S+LDF    + ++ +    R     +++   + F  D  
Sbjct: 2058 KKTAALQSATPVERVKLQEALSQLDFQ---WEKVNKMYKDRQGRFDRSVEKWRRFHYDIK 2114

Query: 3535 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3594
                WL E    L K  + +      +K    L+ LQ+ I  R+  V      G E+++Q
Sbjct: 2115 IFNQWLTEAEQFLRKTQIPENWEHAKYKWY--LKELQDGIGQRQTVVRTLNATGEEIIQQ 2172

Query: 3595 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3654
            ++  +  I+Q+KL ++  R++++ K  +D  K LE+   +         E   WL++ + 
Sbjct: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD- 2231

Query: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG--L 3712
             + S   +  K ++  +   + K L +E    + +L  LNE    +L   P    E   L
Sbjct: 2232 NIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKL 2291

Query: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAIL-------RSQQFDQAADAELSWITETEKKL 3765
            E  + + N ++  VS  + +K  EI+A I        + +  ++  +  L W++    +L
Sbjct: 2292 ENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQL 2351

Query: 3766 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825
                     Q        VQ+T      +  D+ + L K  H       +   Q +K+KL
Sbjct: 2352 EIYN-----QPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYK---EKPATQPVKRKL 2403

Query: 3826 DKVLKNYDTICQINSE-RYLQLERAQ-------------SLVNQFWETYEELWPWLTETQ 3871
            + +   +  + ++  E R  Q + A              +LV Q   T E     L    
Sbjct: 2404 EDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPS 2463

Query: 3872 SIISQLPAPA--------------LEYETLRQQQE---EHRQLRELIAEHKPHIDKMNKT 3914
            S++ ++PA A              L  + ++ Q+    +   + E+I + K  +  + + 
Sbjct: 2464 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2523

Query: 3915 GPQLLEL-----------SPGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQST 3962
             PQL EL           S  E  +I  ++       + +++E ++ R   L+E +  ST
Sbjct: 2524 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2583

Query: 3963 QF---HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4019
            Q+    ++ +Q+L      +E  ++ P     V+ I+++I+E K ++ D+ + Q   +  
Sbjct: 2584 QWLEAKEEAEQVLGQARAKLESWKEGPYT---VDAIQKKITETKQLAKDLRQWQTNVDVA 2640

Query: 4020 KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWC 4079
                 +++ R    D       + + ++     W +IH  V EREA L +   L ++F  
Sbjct: 2641 NDLALKLL-RDYSADDTRKVHMITENINAS---WRSIHKRVSEREAALEETHRLLQQFPL 2696

Query: 4080 DHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL----DIVINL 4135
            D    +  + + +     L+D      +++  +   E +++  D LQ E+    D+  NL
Sbjct: 2697 DLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD-LQGEIEAHTDVYHNL 2755

Query: 4136 GSE----LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQ 4191
                   L +  G  D  ++++ +D +N  W  L K   +    LE +     +    LQ
Sbjct: 2756 DENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQ 2815

Query: 4192 AVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAY------------------Q 4233
             +  W+ +   +L+  +PIG D   V++Q +  + FK E                    +
Sbjct: 2816 ELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTE 2875

Query: 4234 QQIE-MERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLA 4292
            Q +E +E+L  +   L  +   ++    ++    E+   W+ L     + Q K++  L  
Sbjct: 2876 QPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLER 2935

Query: 4293 LGQFQHALDELLAWLTHTEGLLSEQKPVGG-DPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
            L + Q A DEL   L   E +    +PVG     +++  L K   L+ ++   +  V  V
Sbjct: 2936 LQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHV 2995

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4400
            N     L          NL + LE LN RW+ +    E R +QL  A R
Sbjct: 2996 NDLARQLTTLGIQLSPYNL-STLEDLNTRWKLLQVAVEDRVRQLHEAHR 3043



 Score =  313 bits (803), Expect = 2e-84
 Identities = 505/2706 (18%), Positives = 1066/2706 (39%), Gaps = 308/2706 (11%)

Query: 2373 GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA 2432
            G+ L G G  +  EE       T +++ M  ++  +E L +   +K + L+  L  LQ  
Sbjct: 403  GSKLIGTGKLSEDEE-------TEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN- 454

Query: 2433 QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDK 2492
             ++   +  WL K  +   K ++ P   D E +K QV+Q+K  + +L+Q   +V  L   
Sbjct: 455  -QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM 513

Query: 2493 LTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLK 2552
            +  + E + D   A   +Q L  +  +W  + + T DR   L++      +    +    
Sbjct: 514  VVVVDESSGDHATAALEEQ-LKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFS 572

Query: 2553 QWLVEKELMVSVLGPLSI-DPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2611
             WL EKE  V+ +      D N + +  Q++ +L  +   +K    +L +  Q +LS   
Sbjct: 573  AWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL- 631

Query: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS-----------------TQ 2654
            ++ S+    +  L    + WD+L  +L      I QA+  +                 T+
Sbjct: 632  KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691

Query: 2655 YQSLLRSLSDKLSD----------LDNKLSSSLAVS--------THPDAMNQQLETAQKM 2696
             Q L++   ++L            +D+++   L V         T  +A+ Q  E A   
Sbjct: 692  EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 751

Query: 2697 KQ-----------EIQQEKKQ--------IKVAQALCEDL-SALVKEEYLKAELSRQLEG 2736
            K+            I++EK +         + AQAL E + +  V  + +K + S QL  
Sbjct: 752  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIK-QASEQLNS 810

Query: 2737 ILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPIS-AKLDV 2795
                F  +  +  N +++  +  A  +Q QQ+ +     + T  E   K  P + ++   
Sbjct: 811  RWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ-----MTTTAENWLKIQPTTPSEPTA 865

Query: 2796 LESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2855
            ++S +K  KD    L+      E+   + +++ LK +G     L         ++     
Sbjct: 866  IKSQLKICKDEVNRLSGLQPQIERL--KIQSIALKEKGQGPMFLDADFVAFTNHFKQVFS 923

Query: 2856 QVKERENKLKESLEKA--LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAE-GENSIAKLK 2912
             V+ RE +L+   +    ++Y+E +  +  W+ + +  L   +  +   E  E  + +L+
Sbjct: 924  DVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQ 983

Query: 2913 SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLE 2972
            +LQ  + +    +  L+ T      V E+ K+  ++ ++    + + +  +       L 
Sbjct: 984  ALQSSLQEQQSGLYYLSTT------VKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLV 1037

Query: 2973 NMTQKFKEFQEVSKESKRQLQCAKE---QLDIH-----DSLGSQAYSNKYLTMLQTQQKS 3024
               QK +E     ++ +  +Q  K+   ++D+       +LG      K L   +     
Sbjct: 1038 EHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSD 1097

Query: 3025 LQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKL 3084
            +Q ++  ++      Q +  EA + +  S +  +++ +  +   + QQV  +   L+  L
Sbjct: 1098 IQTIQPSLNSVNEGGQKIKNEA-EPEFASRLETELKELNTQWDHMCQQVYARKEALKGGL 1156

Query: 3085 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN 3144
            +     Q  + EM     + ++E        +  + LQK  E +K          A  + 
Sbjct: 1157 EKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKR---------AKEEA 1207

Query: 3145 ANKTCKMMLATEETSPDLV--------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKR 3196
              K  K+ L TE  +  +          +K++LE L+     L  R   + + +E     
Sbjct: 1208 QQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWAC 1267

Query: 3197 LEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDV 3256
              E  S L++ +  L + E   ++   +    E I++ L+  +   +      +     +
Sbjct: 1268 WHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHS----EDNPNQI 1323

Query: 3257 NWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
              L Q L          + +  +L+  N+RW+ L+++  +R   L++++      Q A E
Sbjct: 1324 RILAQTLTDGGVMD---ELINEELETFNSRWRELHEEAVRRQKLLEQSI------QSAQE 1374

Query: 3317 SLLSWMVDTEELVANQKPPSAEF--KVVKAQI-QEQKLLQRLLDDRKSTVEVIKREGEKI 3373
            +  S  +  E L    K  +A    KV  AQ+ QE + +Q  L   + ++E +K+  +  
Sbjct: 1375 TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGK 1434

Query: 3374 ATTAEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3432
                    ++ +  K+L  +  ++      A    R  E   +        L+ +   L 
Sbjct: 1435 EAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI--------LDEVKMHLP 1486

Query: 3433 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKD 3492
             +E + V  E + +Q   L   +  +K+L +        +   +  G+ +      E+  
Sbjct: 1487 ALETKSVEQEVVQSQ---LNHCVNLYKSLSEV----KSEVEMVIKTGRQIVQKKQTENPK 1539

Query: 3493 MVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV 3552
             +  ++   ++ Y E+  K   R + L++ L  ++   ++   L  WL     +L+K S 
Sbjct: 1540 ELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSA 1599

Query: 3553 QDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612
             +     L  + +  +  Q++I  +K ++      G E LK   G +  +++DKL  + +
Sbjct: 1600 VEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG-EALKTVLGKKETLVEDKLSLLNS 1658

Query: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672
             +  +T  + +    L +  +         + +  W+  ++ + L  E++  K ++    
Sbjct: 1659 NWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWI--IQADTLLDESEKKKPQQKEDV 1716

Query: 3673 QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732
                K LK E  + +  +DS  + ++ L+       R+ +E  ++E N R+  +S  I  
Sbjct: 1717 L---KRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRI-- 1771

Query: 3733 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3792
            K  +    +   +QF+              +KL+   +  ++Q     +    K    + 
Sbjct: 1772 KTGKASIPLKELEQFNSDI-----------QKLLEPLEAEIQQGVNLKEEDFNKDMNED- 1819

Query: 3793 LRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLKNYDTICQINSERYLQLERAQS 3851
              ++  + +L++ G  +    ++E K + +K K   +   ++ +  + S+R  +      
Sbjct: 1820 --NEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISH 1877

Query: 3852 LVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKM 3911
               Q+    ++L   L + +  ++ LP P            + R+++E+  E +   +++
Sbjct: 1878 QWYQYKRQADDLLKCLDDIEKKLASLPEP-----------RDERKIKEIDRELQKKKEEL 1926

Query: 3912 NKTGPQLLELSP-GEGFSIQEKYVAADTLYSQIKE---DVKKRAVALDEAISQSTQFHDK 3967
            N    Q   LS  G   +++   +     + +I+      ++   A    + + T     
Sbjct: 1927 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1986

Query: 3968 IDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMI 4027
             D  LE        L +   +S  + ++++ ++     + D E L    E+LK   + + 
Sbjct: 1987 EDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQ 2046

Query: 4028 ARSGGTDKDISAKA-------------VQDKLDQMVFIWENIHTLVEEREAKLLDVMELA 4074
              SG  D   S K              +Q+ L Q+ F WE ++ + ++R+ +    +E  
Sbjct: 2047 QSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKW 2106

Query: 4075 EKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAET---IREEIDGLQEELDI 4131
             +F  D       + + + F+R  + P        +  E A+    ++E  DG+ +   +
Sbjct: 2107 RRFHYDIKIFNQWLTEAEQFLRKTQIP--------ENWEHAKYKWYLKELQDGIGQRQTV 2158

Query: 4132 VINL---GSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQD 4188
            V  L   G E+I    + D  I+++ +  LN  W  + K   DR  +LEE      ++Q 
Sbjct: 2159 VRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQR 2218

Query: 4189 GLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELL 4248
             L     W++ A   +AS+       + +K+++E++K    E   +Q  +++LN     +
Sbjct: 2219 DLNEFVLWLEEADN-IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPV 2277

Query: 4249 LKKVT---EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL-- 4303
            L       EE DK  +++ L +  L W  +   +  +Q ++E  +  LGQ +  L++L  
Sbjct: 2278 LVSAPISPEEQDK--LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEE 2335

Query: 4304 -----LAWLTHTEGLLS--EQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGN 4356
                 L WL+     L    Q    G     E E+A        V A Q  VE +   G 
Sbjct: 2336 QLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIA--------VQAKQPDVEEILSKGQ 2387

Query: 4357 DLIESSAGEEASNLQNKLEVLNQRWQNV-------------------------------- 4384
             L +     +   ++ KLE L+  W+ V                                
Sbjct: 2388 HLYKEKPATQP--VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLV 2445

Query: 4385 -----LEKTEQRKQQLDGALR----QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET 4435
                  ++T   K ++  +L         F+    +L  WL+  ++ + + + + G  E 
Sbjct: 2446 TQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLED 2505

Query: 4436 AKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCP-KSAETNIDQDINNLKEKWESVE 4494
              E +          E +    + L+   Q +  +   + A T I   I  ++ +W+ V+
Sbjct: 2506 INEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQ 2565

Query: 4495 TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV 4554
              L  R+ +L E L  + ++  + ++    L QA   L         +D +  +I E K 
Sbjct: 2566 EHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQ 2625

Query: 4555 FANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLD 4614
             A ++   +  +   +     L       D   +  +  ++ + W  + +R+ ER  +L+
Sbjct: 2626 LAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE 2685

Query: 4615 DARKRAKQFHEAWSKLMEWLEESEKSLD------SELEIANDPDKIKTQLAQHKEFQKSL 4668
            +  +  +QF     K + WL E+E + +       +  +  D   +K  + Q ++ Q  +
Sbjct: 2686 ETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEI 2745

Query: 4669 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728
             A   VY   +   + +      +DD + L   L  +  KW  +  KS+  ++ LE +  
Sbjct: 2746 EAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSD 2805

Query: 4729 FSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRT------ 4782
               +   +LQ L+ WL   + +L+   P+ GD   V    D H+AF++EL  +       
Sbjct: 2806 QWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMST 2865

Query: 4783 -------------SSVQALKRSARELI--EGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
                           ++ L +  REL   E +++ +  ++ Q +E++T WE +   S   
Sbjct: 2866 LETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADW 2925

Query: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887
            Q +++  L + +E       L   L +AE        + D       LID  ++ ++K++
Sbjct: 2926 QRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGD------LLIDSLQDHLEKVK 2979

Query: 4888 EKRAEL 4893
              R E+
Sbjct: 2980 ALRGEI 2985



 Score =  308 bits (789), Expect = 1e-82
 Identities = 502/2696 (18%), Positives = 1071/2696 (39%), Gaps = 346/2696 (12%)

Query: 2650 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2709
            V   +YQ+ L  +   L   ++ L +   +S   + +  Q  T +    ++   + ++  
Sbjct: 339  VNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGN 398

Query: 2710 AQALCEDLSALVK-EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQM 2768
               L   L    K  E  + E+  Q+  +L S  +  + A    Q          Q Q++
Sbjct: 399  ILQLGSKLIGTGKLSEDEETEVQEQMN-LLNSRWECLRVASMEKQSNLHRVLMDLQNQKL 457

Query: 2769 SRDFQAWLDTKKEEQNKS---HPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
             ++   WL TK EE+ +     P+   L+ L+  ++ HK   + L  Q  +   ++    
Sbjct: 458  -KELNDWL-TKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLE-QEQVRVNSLTHMV 514

Query: 2826 NLLLKTQGSEK-AALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2884
             ++ ++ G    AAL+ QL  +   W    +  ++R   L++ L K  +  E+      W
Sbjct: 515  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574

Query: 2885 IDKCQNNLEEIKFC--LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEID 2942
            + + ++ + +I      D  E  +S+ KL  L+ ++++    +  L +    LLS   + 
Sbjct: 575  LSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST--LK 632

Query: 2943 KEVVTDENKS-----------LIQKVDMVTEQLH----------SKKFCLENMTQKFKEF 2981
             + VT + ++           L+QK++  T Q+           ++   +E +T      
Sbjct: 633  NKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTRE 692

Query: 2982 QEVSK-----------ESKRQLQCAKE---QLDIHDSLGSQAYSNKYLTMLQT------- 3020
            Q + K           + KRQ+    E   +LD+ D     ++  +   +LQ+       
Sbjct: 693  QILVKHAQEELPPPPPQKKRQITVDSEIRKRLDV-DITELHSWITRSEAVLQSPEFAIFR 751

Query: 3021 QQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQ--------VETIAQEHSTLSQQ 3072
            ++ +   LK +V+  +R   +   +  D+  ++  L++         ++I Q    L+ +
Sbjct: 752  KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 811

Query: 3073 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3132
              E C  L  +L  +  +QN I   ++Q  + +    +     +   T   +   IK+ L
Sbjct: 812  WIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQL 870

Query: 3133 K----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREE 3188
            K    ++  L        +     +A +E     + +  D  A +    ++    QARE+
Sbjct: 871  KICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 930

Query: 3189 QVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3246
            +++     L    +   +      +Q++E           + E + Q+L   +  Q    
Sbjct: 931  ELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSS-- 988

Query: 3247 EPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3304
              LQ +Q  + +L   + + + K+ S  ++  + + +++  RWK L+ ++ +   +L+E 
Sbjct: 989  --LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 1046

Query: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3364
            +    + Q+ +++L  WM + +  +  + P   + +++K Q+++ +LL   +   + ++ 
Sbjct: 1047 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLN 1106

Query: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3424
             +   G+KI   AEP    ++  +L  L+++W+ +  +   R   L+G         + L
Sbjct: 1107 SVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDL 1166

Query: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKV 3484
              ++EW+T  E+  +  +       +L++ + + K  +++       +        S+  
Sbjct: 1167 SEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1226

Query: 3485 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKIFGEDEVELMNWLNEV 3543
             +    ++ ++ +L+     Y  +  + + + + L++   C  ++    E +   WLNEV
Sbjct: 1227 QAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLE-KANKWLNEV 1285

Query: 3544 HDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLNGLELLKQTTGDEVL- 3601
              KL        +TE +     E+  VL     L + + D    N + +L QT  D  + 
Sbjct: 1286 EFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--NQIRILAQTLTDGGVM 1336

Query: 3602 --IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH-STH--EELCTWLDK----- 3651
              +I ++LE   +R++++ + +    K LEQ++Q A+    S H  +E  T++DK     
Sbjct: 1337 DELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAY 1396

Query: 3652 ----------------VEVELLSYETQVLK------GEEASQAQM--------------- 3674
                            ++ +L S+E  + +      G+EA+Q  +               
Sbjct: 1397 IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM 1456

Query: 3675 ------RPKELKKEAKNNKALLD-------------------------------SLNEVS 3697
                  +P   ++  + +K +LD                               SL+EV 
Sbjct: 1457 KFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVK 1516

Query: 3698 SALLELVPWRAREGLEKMVAED----NER-------YRLVSDTITQKVEEIDAAILRSQQ 3746
            S + E+V    R+ ++K   E+    +ER       Y  +   +T++ ++++  +  S++
Sbjct: 1517 SEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRK 1575

Query: 3747 FDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806
              +  +    W+  T+ +L     +        +++   K    EI + K  +  + + G
Sbjct: 1576 MRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVG 1635

Query: 3807 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866
              + T   ++E   ++ KL  +  N+  +     E    L   Q  +  F +  + +  W
Sbjct: 1636 EALKTVLGKKETL-VEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKW 1694

Query: 3867 LTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEG 3926
            + +  +++        E E  + QQ+E   L+ L AE      K++ T  Q   L    G
Sbjct: 1695 IIQADTLLD-------ESEKKKPQQKED-VLKRLKAELNDIRPKVDSTRDQAANLMANRG 1746

Query: 3927 FS----IQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL 3982
                  ++ +    +  ++ I   +K    ++   + +  QF+  I ++LE LE  +++ 
Sbjct: 1747 DHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFNSDIQKLLEPLEAEIQQ- 1803

Query: 3983 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042
                 ++ + E   + ++E+   +V         + L QRG+ +  R     K    K  
Sbjct: 1804 ----GVNLKEEDFNKDMNEDNEGTV---------KELLQRGDNLQQRITDERKREEIKIK 1850

Query: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4102
            Q  L         +  L  +R  K L++     ++      L+  + D +  +  L +P 
Sbjct: 1851 QQLLQTK---HNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1907

Query: 4103 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4162
             D   +K+     +  +EE++ ++ + +    L  +  A   EP +  + K   E+ S +
Sbjct: 1908 -DERKIKEIDRELQKKKEELNAVRRQAE---GLSEDGAAMAVEPTQIQLSKRWREIESKF 1963

Query: 4163 DSLNKAWKDRIDKL-EEAMQAAVQ------------YQDGLQAVFDWVDIAGGKLASMSP 4209
                +    +I  + EE M    +            Y   +  V   +      L +   
Sbjct: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDL 2023

Query: 4210 IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4269
               D E + +Q E LK  K    Q    ++ ++ +    L+  T   ++  +Q+ L +L 
Sbjct: 2024 CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-ERVKLQEALSQLD 2082

Query: 4270 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSE-QKPVGGDPKAIE 4328
              W+ + +   +RQ + + ++    +F + +     WLT  E  L + Q P   +    +
Sbjct: 2083 FQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYK 2142

Query: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4388
              L +   LQ+ +   Q+ V  +N  G ++I+ S+  +AS LQ KL  LN RWQ V ++ 
Sbjct: 2143 WYLKE---LQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQL 2199

Query: 4389 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-GLPETAKEQLNVHMEVC 4447
              RK++L+        F  ++ +   WL + +   +AS PL  G  +  KE+L     + 
Sbjct: 2200 SDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN--IASIPLEPGKEQQLKEKLEQVKLLV 2257

Query: 4448 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE---KWESVETKLNERKTKL 4504
                 ++   K L + G  +L   P S E   D+  N LK+   +W  V   L E++ ++
Sbjct: 2258 EELPLRQGILKQLNETGGPVLVSAPISPEEQ-DKLENKLKQTNLQWIKVSRALPEKQGEI 2316

Query: 4505 EEALNLAMEFHNSLQDF-------INWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFAN 4557
            E  +    +    L+D        + WL+     L + ++P+       F + E ++   
Sbjct: 2317 EAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGPFDVQETEI--- 2370

Query: 4558 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGR------ 4611
             V + +  + E+   G HL  + +K     +K  L  + S W K V RL++  R      
Sbjct: 2371 AVQAKQPDVEEILSKGQHL--YKEKPATQPVKRKLEDLSSEW-KAVNRLLQELRAKQPDL 2427

Query: 4612 ------------------------------------SLDDARKRAKQFHEAWSKLMEWLE 4635
                                                SL         F+ AW++L +WL 
Sbjct: 2428 APGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLS 2487

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4695
              ++ + S+  +  D + I   + + K   + L  +    +      ++LK KTS  +  
Sbjct: 2488 LLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEAR 2547

Query: 4696 LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQ 4755
              + D +  ++++WD +      R+ +L E L  S Q+ +A +     L +   +L   +
Sbjct: 2548 TIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWK 2607

Query: 4756 PVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEG-SRDDSSWVKVQMQELS 4814
                 +D +   I   K   K+L +  ++V      A +L+   S DD+  V +  + ++
Sbjct: 2608 EGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENIN 2667

Query: 4815 TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRT 4874
              W ++      ++  LE   R  ++F   +   L WL EAE T     VL D     R 
Sbjct: 2668 ASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTAN---VLQDATRKERL 2724

Query: 4875 LIDQH--KEFMKKLEEKRAELNKATTMGDTV--------LAICHPDSITTIKHWITIIRA 4924
            L D    KE MK+ ++ + E+   T +   +         ++   D    ++  +  +  
Sbjct: 2725 LEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNF 2784

Query: 4925 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVK 4984
            ++ E+   +   +  L ++          L+ LL WLQ  +  L+ +    I  +   V+
Sbjct: 2785 KWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAP--IGGDFPAVQ 2842

Query: 4985 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLY 5044
                 H+ F  E+  K+P +    +T +            I + ++   G ++     LY
Sbjct: 2843 KQNDVHRAFKRELKTKEPVIMSTLETVR------------IFLTEQPLEGLEK-----LY 2885

Query: 5045 PSGSQTQIETKNPRVNLLVSK--------WQQVWLLALERRRKLNDALDRLEELRE 5092
                +   E +   V  L+ K        W+++ L + + +RK+++ L+RL+EL+E
Sbjct: 2886 QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQE 2941



 Score =  295 bits (755), Expect = 8e-79
 Identities = 474/2585 (18%), Positives = 1053/2585 (40%), Gaps = 294/2585 (11%)

Query: 2534 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2593
            L ES  NL ++QT   ++  WL+  E  +   G +S D  ++  Q    +  + +    +
Sbjct: 334  LMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQ 393

Query: 2594 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2653
             +   +   G  ++            V+EQ+  +  +W+ L     ++   + + ++   
Sbjct: 394  GRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQ 453

Query: 2654 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA--MNQQLETAQKMKQEIQQEKKQIK--V 2709
              +  L+ L+D L+  + +          PD   + +Q++  + ++++++QE+ ++    
Sbjct: 454  NQK--LKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLT 511

Query: 2710 AQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2769
               +  D S+    ++  A L  QL+ +   + ++ +  E+    LQ       +  +  
Sbjct: 512  HMVVVVDESS---GDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQ 568

Query: 2770 RDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLL 2829
              F AWL  K++  NK H             KD  +   +L                   
Sbjct: 569  CLFSAWLSEKEDAVNKIHTTG---------FKDQNEMLSSL------------------- 600

Query: 2830 KTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID--- 2886
                 + A L+  L           KQ   +   LK+ L   LK K   +    W+D   
Sbjct: 601  ----QKLAVLKADLEK--------KKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFA 648

Query: 2887 KCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2946
            +C +NL +    L+ +  + S A + + Q  + Q   M  +   T    + V    +E+ 
Sbjct: 649  RCWDNLVQ---KLEKSTAQISQA-VTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELP 704

Query: 2947 TDE---------NKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE 2997
                        +  + +++D+   +LHS     E + Q   EF    KE        KE
Sbjct: 705  PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQS-PEFAIFRKEG--NFSDLKE 761

Query: 2998 QLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3057
            +++  +   ++ +       LQ   +S QAL               VE   ++G     +
Sbjct: 762  KVNAIEREKAEKFRK-----LQDASRSAQAL---------------VEQMVNEG-----V 796

Query: 3058 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3117
              ++I Q    L+ +  E C  L  +L  +  +QN I   ++Q  + +    +     + 
Sbjct: 797  NADSIKQASEQLNSRWIEFCQLLSERLNWL-EYQNNIIAFYNQLQQLEQMTTTAENWLKI 855

Query: 3118 AETLQKQKETIKAFLK----KLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALS 3173
              T   +   IK+ LK    ++  L        +     +A +E     + +  D  A +
Sbjct: 856  QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 915

Query: 3174 KQCNKLLDRAQAREEQVEGTIKRLE--EFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3231
                ++    QARE++++     L    +   +      +Q++E           + E +
Sbjct: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975

Query: 3232 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTS--TQGLEHDLDDVNARWKT 3289
             Q+L   +  Q      LQ +Q  + +L   + + + K+ S  ++  + + +++  RWK 
Sbjct: 976  EQRLGELQALQSS----LQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKK 1031

Query: 3290 LNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3349
            L+ ++ +   +L+E +    + Q+ +++L  WM + +  +  + P   + +++K Q+++ 
Sbjct: 1032 LSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQC 1091

Query: 3350 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQ 3409
            +LL   +   + ++  +   G+KI   AEP    ++  +L  L+++W+ +  +   R   
Sbjct: 1092 RLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151

Query: 3410 LEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHN 3469
            L+G         + L  ++EW+T  E+  +  +       +L++ + + K  +++     
Sbjct: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211

Query: 3470 KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA-LCNAKI 3528
              +        S+   +    ++ ++ +L+     Y  +  + + + + L++   C  ++
Sbjct: 1212 AKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHEL 1271

Query: 3529 FGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL-RVLQEDILLRKQNVDQALLN 3587
                E +   WLNEV  KL        +TE +     E+  VL     L + + D    N
Sbjct: 1272 LSYLE-KANKWLNEVEFKLK-------TTENIPGGAEEISEVLDSLENLMRHSEDNP--N 1321

Query: 3588 GLELLKQTTGDEVL---IIQDKLEAIKARYKDITKLSTDVAKTLEQALQLA----RRLHS 3640
             + +L QT  D  +   +I ++LE   +R++++ + +    K LEQ++Q A    + LH 
Sbjct: 1322 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1381

Query: 3641 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSAL 3700
              E L T++DK   +L +Y   +    +A+Q     ++++ +  +++  L+ + + +   
Sbjct: 1382 IQESL-TFIDK---QLAAY---IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHN--- 1431

Query: 3701 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ---FDQAADAELSW 3757
                  + +E  ++++++         D   +K++++       Q+   F+Q        
Sbjct: 1432 ------QGKEAAQRVLSQ--------IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMI 1477

Query: 3758 ITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEE 3817
            + E +  L +L    +EQ+   +QL         +   K  ++ ++K+G +I+     E 
Sbjct: 1478 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1537

Query: 3818 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3877
             + + +++  +  +Y+ +    +ER  QLE+   L  +  +    L  WL  T   +++ 
Sbjct: 1538 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1597

Query: 3878 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3937
             A       L  +    +  ++ I + K H+  + + G  L  +   +   +++K     
Sbjct: 1598 SAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKL---- 1653

Query: 3938 TLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKE 3997
            +L +     V  RA   +E ++   ++   ++   ++++ I + + Q  ++  E EK K 
Sbjct: 1654 SLLNSNWIAVTSRA---EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1710

Query: 3998 QISEN--KNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4055
            Q  E+  K +  ++  ++P  ++ + +   ++A  G    D   K V+ ++ ++   +  
Sbjct: 1711 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----DHCRKLVEPQISELNHRFAA 1766

Query: 4056 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4115
            I   ++  +A +   ++  E+F  D   L+  ++       +L++   +  + +  +   
Sbjct: 1767 ISHRIKTGKASI--PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTV 1824

Query: 4116 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4175
            + + +  D LQ+ +               E  +  +K     L +  ++L      R  K
Sbjct: 1825 KELLQRGDNLQQRI-------------TDERKREEIKIKQQLLQTKHNALKDLRSQRRKK 1871

Query: 4176 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ 4235
              E      QY+     +   +D    KLAS+ P   D   +K+   EL++ K       
Sbjct: 1872 ALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQKKKE------ 1924

Query: 4236 IEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN-------RQHKL-E 4287
             E+  +  QAE L    +E+     V+   ++L   W  +E +          + H + E
Sbjct: 1925 -ELNAVRRQAEGL----SEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVRE 1979

Query: 4288 GALLALG-----QFQHALDELLAWLTHTEGLLSEQKPVGGDP----KAIEIELAKHHVLQ 4338
              ++ +      +  +     L  +TH    L E + +   P    K  E    +   L+
Sbjct: 1980 ETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLK 2039

Query: 4339 N--DVLAHQS-TVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQL 4395
            N  D L   S  ++ ++      ++S+   E   LQ  L  L+ +W+ V +  + R+ + 
Sbjct: 2040 NIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRF 2099

Query: 4396 DGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPET---AKEQLNVHMEVCAAFEA 4452
            D ++ + + FH +I+   QWLT+ E+ L  ++    +PE    AK +  +  E+      
Sbjct: 2100 DRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ----IPENWEHAKYKWYL-KELQDGIGQ 2154

Query: 4453 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4512
            ++   ++L   G++++ +  K+  + + + + +L  +W+ V  +L++RK +LEE  N+  
Sbjct: 2155 RQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILS 2214

Query: 4513 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4572
            EF   L +F+ WL +A+   ++   P      +  ++++ K+   E+   +  + +L++T
Sbjct: 2215 EFQRDLNEFVLWLEEADNIASIPLEPGK-EQQLKEKLEQVKLLVEELPLRQGILKQLNET 2273

Query: 4573 G----THLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERG-------RSLDDARKRAK 4621
            G           ++QD   ++N L     +W KV + L E+        + L    K+ +
Sbjct: 2274 GGPVLVSAPISPEEQD--KLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLE 2331

Query: 4622 QFHEAWSKLMEWLEESEKSLDSELEIANDP------DKIKTQL---AQHKEFQKSLGAKH 4672
               E  + L+ WL      + ++LEI N P      D  +T++   A+  + ++ L    
Sbjct: 2332 DLEEQLNHLLLWL----SPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQ 2387

Query: 4673 SVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWD------TICGKS---------- 4716
             +Y     T    ++   L+ +   ++ +L ELR K        T  G S          
Sbjct: 2388 HLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQ 2447

Query: 4717 -----------VERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4765
                       +E  + L   +     F  A   L DWL  ++  +   + + GD++ + 
Sbjct: 2448 PVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDIN 2507

Query: 4766 NLIDNHKAFQKELGKRTSSVQALKRSARELIE--GSRDDSSWVKVQMQELSTRWETVCAL 4823
             +I   KA  ++L +R   ++ L  +A+ L     +++  + +  +++ +  +W+ V   
Sbjct: 2508 EMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEH 2567

Query: 4824 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4883
              +++ +L   L+ + ++        + L +A   L      P   DA++  I + K+  
Sbjct: 2568 LQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLA 2627

Query: 4884 KKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASA 4943
            K L + +  ++ A  +   +L     D    + H IT      E + A  +   +R++  
Sbjct: 2628 KDLRQWQTNVDVANDLALKLLRDYSADDTRKV-HMIT------ENINASWRSIHKRVSER 2680

Query: 4944 LAGLIAKQEL-------LEALLAWLQWAETT---LTDKD-KEVIPQEIEEVKALIAEHQT 4992
             A L     L       LE  LAWL  AETT   L D   KE + ++ + VK L+ + Q 
Sbjct: 2681 EAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQD 2740

Query: 4993 FMEEM 4997
               E+
Sbjct: 2741 LQGEI 2745



 Score =  277 bits (708), Expect = 2e-73
 Identities = 491/2725 (18%), Positives = 1089/2725 (39%), Gaps = 258/2725 (9%)

Query: 2077 QDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2136
            Q  L+E+L W+ + E +L+ QG++  +   ++D    +     D+   Q  +  + +   
Sbjct: 345  QTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGS 404

Query: 2137 KFMETTDPST--ASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQT 2194
            K + T   S    + +Q +M  L++R+        E  + +   +  ++L     ++L  
Sbjct: 405  KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH--RVLMDLQNQKLKELND 462

Query: 2195 FLETKTQALT---EVDVPGKDVTELSQYMQESTSEFLEHK---KHLEVLHSLLKEISSHG 2248
            +L TKT+  T   E +  G D+ +L + +Q+       HK   + LE     +  ++   
Sbjct: 463  WL-TKTEERTRKMEEEPLGPDLEDLKRQVQQ-------HKVLQEDLEQEQVRVNSLTHMV 514

Query: 2249 LPSDKALVLEKTNNLSKKFKEMEDT----IKEKKEAVTSCQEQLDAFQVLVKS---LKSW 2301
            +  D++     T  L ++ K + D      +  ++     Q+ L  +Q L +      +W
Sbjct: 515  VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574

Query: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ--------------EKWSLKTPEIQKVNN 2347
            + E    V  +  + G +D  + L   +KL               + +SLK   +  + N
Sbjct: 575  LSEKEDAVNKIHTT-GFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKN 633

Query: 2348 SGIS------LCNLI----SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSI 2397
              ++      L N      + V    K+ A +    AV   + + T T        +T+ 
Sbjct: 634  KSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQ--AVTTTQPSLTQTTVMETVTTVTT- 690

Query: 2398 KKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTP 2457
             ++   + H  E+L      K  ++       ++   + + +  W+ +         Q+P
Sbjct: 691  -REQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL----QSP 745

Query: 2458 --APTDTEAVKTQVEQN-KSFEAELKQNVNKVQELKDKLTELLEENPDTP-EAPRWKQML 2513
              A    E   + +++   + E E  +   K+Q+       L+E+  +    A   KQ  
Sbjct: 746  EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805

Query: 2514 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2573
             +++S+W E  QL  +R   LE   NN+  F     QL+Q     E  + +      +P 
Sbjct: 806  EQLNSRWIEFCQLLSERLNWLEYQ-NNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPT 864

Query: 2574 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2633
             + +Q +  +  +   +  +PQ E+L       L   G+ P     +     A T  +  
Sbjct: 865  AIKSQLKICKDEVNRLSGLQPQIERLKIQSIA-LKEKGQGPMF---LDADFVAFTNHFKQ 920

Query: 2634 LTGQLSDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2691
            +   +  R   +      +   +YQ  + ++   +   + KLS      T  + M Q+L 
Sbjct: 921  VFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLG 980

Query: 2692 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2751
              Q ++  +Q+++  +       +++S     E +  +   + E I   +K +  +   H
Sbjct: 981  ELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSE-ISRKYQSEFEEIEGRWKKLSSQLVEH 1039

Query: 2752 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2811
             Q L+       + Q   +  + W+        +  P     ++L+  +K  +     + 
Sbjct: 1040 CQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ 1099

Query: 2812 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKA 2871
                        G+ +  + +    + L+ +L  + T WD   +QV  R+  LK  LEK 
Sbjct: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159

Query: 2872 LKYKEQVETLWPWIDKCQNNLEEIKF-CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNN 2930
            +  ++ +  +  W+ + +    E  F    P E + ++ ++K  ++E  Q    V+LL  
Sbjct: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTE 1219

Query: 2931 TANSLLSVCE-IDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESK 2989
            + NS+++    + +E +  E ++L      +  +L+ K   LE +   + E     +++ 
Sbjct: 1220 SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKAN 1279

Query: 2990 RQLQCAKEQLDIHDSL-GSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD 3048
            + L   + +L   +++ G     ++ L  L+   +  +   +Q+ +   LAQ L      
Sbjct: 1280 KWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRI---LAQTLT----- 1331

Query: 3049 SKGTSDVLL--QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDD 3106
              G  D L+  ++ET       L ++   +   LE  +Q     + ++  +       D 
Sbjct: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391

Query: 3107 ELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIK 3166
            +L +      DA  + ++ + I++ L   E                ++ EE      G +
Sbjct: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHE----------------ISLEEMKKHNQGKE 1435

Query: 3167 RDLEALSKQCNKLLDRAQAREEQVEGTIKRLEE---FYSKLKEFSILLQKAEEHEESQGP 3223
                 LS+     +D AQ + + V    +  ++   F  +L+E  ++L + + H  +   
Sbjct: 1436 AAQRVLSQ-----IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALET 1490

Query: 3224 VGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDV 3283
              +E E +  QLN      K  +  ++ + + V   G+ ++Q   ++ + + L+  +  +
Sbjct: 1491 KSVEQEVVQSQLNHCVNLYKS-LSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTAL 1548

Query: 3284 NARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK 3343
               +  L  KV +R  QL++ L    + +  +  L  W+  T+  +  +         + 
Sbjct: 1549 KLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD 1608

Query: 3344 AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3403
            +++   K  Q+ ++ +K  ++ I   GE + T     + + +  +LSLL+S W A+ ++A
Sbjct: 1609 SEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL-VEDKLSLLNSNWIAVTSRA 1667

Query: 3404 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3463
            E     L       + F + ++ + +W+   +  L   E    Q    E+ + + KA  +
Sbjct: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQK--EDVLKRLKAELN 1725

Query: 3464 DIINHNKHLHQAVSIGQSLKVLSSRED--KDMVQSKLD-----FSQVWY-IEIQEKSHSR 3515
            DI              Q+  ++++R D  + +V+ ++      F+ + + I+  + S   
Sbjct: 1726 DIRPKVDSTRD-----QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPL 1780

Query: 3516 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ------QSELRV 3569
             EL Q      K+    E E+   +N   +  +K   +D   EG  K+        + R+
Sbjct: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNED--NEGTVKELLQRGDNLQQRI 1838

Query: 3570 LQE---DILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAK 3626
              E   + +  KQ + Q   N L+ L+     + L I  +    K +  D+ K   D+ K
Sbjct: 1839 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1898

Query: 3627 TLEQALQLA--RRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA-QMRPKELKKEA 3683
             L    +    R++     EL     K E+  +  + + L  + A+ A +    +L K  
Sbjct: 1899 KLASLPEPRDERKIKEIDRELQK--KKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRW 1956

Query: 3684 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNE-RYRLVSDTITQKVEEIDAAIL 3742
            +  ++       ++ A +  V    RE    ++ ED       V  T   ++  +  A+L
Sbjct: 1957 REIESKFAQFRRLNFAQIHTV----REETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2012

Query: 3743 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3802
              +Q   A D       +  K+  SL +I+    Q+S ++ +  +     L+    ++ +
Sbjct: 2013 EVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2072

Query: 3803 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3862
                 K+  A S+ + Q   +K++K+ K+       + E++ +      + NQ       
Sbjct: 2073 -----KLQEALSQLDFQW--EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQ------- 2118

Query: 3863 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3922
               WLTE +  + +   P  E     + +   ++L++ I + +  +  +N TG ++++ S
Sbjct: 2119 ---WLTEAEQFLRKTQIP--ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQS 2173

Query: 3923 PGEGFSI-QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVER 3981
                 SI QEK  + +  + ++ + +  R   L+E  +  ++F   +++ +  LE   + 
Sbjct: 2174 SKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEE-ADN 2232

Query: 3982 LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKA 4041
            +   P    + +++KE++ + K +  ++   Q + + L + G  ++  +  + ++     
Sbjct: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEE--QDK 2290

Query: 4042 VQDKLDQMVFIWENIHTLVEER----EAKLLDVMELAEKF-----WCDHMSLIVTIKDTQ 4092
            +++KL Q    W  +   + E+    EA++ D+ +L +K        +H  L++ +   +
Sbjct: 2291 LENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNH--LLLWLSPIR 2348

Query: 4093 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4152
            + +     P  +     Q+ E A      +   Q +++ +++ G  L     +P    VK
Sbjct: 2349 NQLEIYNQPNQEGPFDVQETEIA------VQAKQPDVEEILSKGQHLYKE--KPATQPVK 2400

Query: 4153 KSIDELNSAWDSLNKAWKD-----------------------------------RIDKLE 4177
            + +++L+S W ++N+  ++                                    I KLE
Sbjct: 2401 RKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLE 2460

Query: 4178 EA------MQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEA 4231
                    + A   +      + DW+ +    + S   +  DLE + + I + K    + 
Sbjct: 2461 MPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDL 2520

Query: 4232 YQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALL 4291
             Q++ ++E L   A+ L  K + +  +  + D +  ++  WD ++E + NR+ +L   L 
Sbjct: 2521 EQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLK 2580

Query: 4292 ALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAV 4351
               Q+  A +E    L      L   K       AI+ ++ +   L  D+   Q+ V+  
Sbjct: 2581 DSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640

Query: 4352 NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIED 4411
            N     L+   + ++   +    E +N  W+++ ++  +R+  L+   R  + F  ++E 
Sbjct: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700

Query: 4412 LQQWLTDTE------RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQ 4465
               WLT+ E      +     + L    +  KE +    ++    EA  + Y +L +  Q
Sbjct: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQ 2760

Query: 4466 QMLARCPKSAE-TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4524
            ++L     S +   + + ++N+  KW  +  K    ++ LE + +     H SLQ+ + W
Sbjct: 2761 KILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVW 2820

Query: 4525 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4584
            L   +  L+  +        V  Q D H+ F  E+ +    I+   +T   ++ F  +Q 
Sbjct: 2821 LQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET---VRIFLTEQP 2877

Query: 4585 VVLIKNLL-----ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL----MEWLE 4635
            +  ++ L      +  + R + V + L          RK+A++ +  W KL     +W  
Sbjct: 2878 LEGLEKLYQEPRELPPEERAQNVTRLL----------RKQAEEVNTEWEKLNLHSADWQR 2927

Query: 4636 ESEKSLDSELEIANDPDKIKTQLAQ 4660
            + +++L+   E+    D++  +L Q
Sbjct: 2928 KIDETLERLQELQEATDELDLKLRQ 2952



 Score =  226 bits (576), Expect = 5e-58
 Identities = 345/1758 (19%), Positives = 713/1758 (40%), Gaps = 172/1758 (9%)

Query: 3299 AQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDD 3358
            + L E+ ++  R+Q ALE +LSW++  E+ +  Q   S + +VVK Q    +     L  
Sbjct: 332  SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTA 391

Query: 3359 RKSTVEVIKREGEKIATTAEPA--DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVV 3416
             +  V  I + G K+  T + +  ++ ++ +Q++LL+SRWE L   +  +   L  + + 
Sbjct: 392  HQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMD 451

Query: 3417 AQQFHETLEPLNEWLTTIEKRL--VNCEPIGTQASKLEEQIAQHKALEDDI----INHNK 3470
             Q  ++ L+ LN+WLT  E+R   +  EP+G     L+ Q+ QHK L++D+    +  N 
Sbjct: 452  LQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNS 509

Query: 3471 HLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFG 3530
              H  V + +S    S       ++ +L      +  I   +  R  LLQ  L   +   
Sbjct: 510  LTHMVVVVDES----SGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565

Query: 3531 EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLE 3590
            E++     WL+E  D ++K+      T G   Q   L  LQ+  +L+           LE
Sbjct: 566  EEQCLFSAWLSEKEDAVNKI-----HTTGFKDQNEMLSSLQKLAVLKAD---------LE 611

Query: 3591 LLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLD 3650
              KQ+ G    + QD L  +K +                          S  ++   WLD
Sbjct: 612  KKKQSMGKLYSLKQDLLSTLKNK--------------------------SVTQKTEAWLD 645

Query: 3651 KVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRARE 3710
                    ++  V K E+++    +     + +     +++++  V++    LV   A+E
Sbjct: 646  NF---ARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK-HAQE 701

Query: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770
             L        ++ ++  D+  +K  ++D   L             SWIT +E  L S   
Sbjct: 702  ELPP--PPPQKKRQITVDSEIRKRLDVDITELH------------SWITRSEAVLQSPEF 747

Query: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDI--IDDLVKSGHKIMTACSEE--EKQSMKKKLD 3826
                ++   + L+ +K   +E  + +    + D  +S   ++     E     S+K+  +
Sbjct: 748  AIFRKEGNFSDLK-EKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASE 806

Query: 3827 KVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYET 3886
            ++   +   CQ+ SER   LE   +++  F+   ++L    T  ++ +   P    E   
Sbjct: 807  QLNSRWIEFCQLLSERLNWLEYQNNII-AFYNQLQQLEQMTTTAENWLKIQPTTPSEPTA 865

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946
            ++ Q +  +     ++  +P I+++      L E   G  F +   +VA    + Q+  D
Sbjct: 866  IKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMF-LDADFVAFTNHFKQVFSD 924

Query: 3947 VKKRAVALDEAIS--QSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKN 4004
            V+ R   L          ++ + +  I   +++   +L  P     + E +++++ E + 
Sbjct: 925  VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQA 984

Query: 4005 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
            +   +++ Q     L    +EM   S     +IS K  Q + +++   W+ + + + E  
Sbjct: 985  LQSSLQEQQSGLYYLSTTVKEM---SKKAPSEISRK-YQSEFEEIEGRWKKLSSQLVEHC 1040

Query: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI-DPSVVKQQQEAAETIREEID 4123
             KL + M    K      +L   + +   F+++ E P + D  ++K+Q +    +  +I 
Sbjct: 1041 QKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKE-EWPALGDSEILKKQLKQCRLLVSDIQ 1099

Query: 4124 GLQEELDIVINLGSELIAACGEPD-KPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQA 4182
             +Q  L+ V N G + I    EP+    ++  + ELN+ WD + +    R + L+  ++ 
Sbjct: 1100 TIQPSLNSV-NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEK 1158

Query: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242
             V  Q  L  + +W+  A  +           + +++ +EE+K+ K EA Q++ +++ L 
Sbjct: 1159 TVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLT 1218

Query: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDE 4302
                 ++ +    + +  ++  L  L   +  L  R+  +   LE       +    L++
Sbjct: 1219 ESVNSVIAQAPPVA-QEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEK 1277

Query: 4303 LLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS 4362
               WL   E  L   + + G  + I   L     L+N +   +     +      L +  
Sbjct: 1278 ANKWLNEVEFKLKTTENIPGGAEEISEVLDS---LENLMRHSEDNPNQIRILAQTLTDGG 1334

Query: 4363 AGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERH 4422
              +E  N   +LE  N RW+ + E+  +R++ L+ +++ A+     +  +Q+ LT  ++ 
Sbjct: 1335 VMDELIN--EELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQ 1392

Query: 4423 LLA----SKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4478
            L A          +P+ A++   +  ++ +   + EE     M+K  Q      K A   
Sbjct: 1393 LAAYIADKVDAAQMPQEAQK---IQSDLTSHEISLEE-----MKKHNQ-----GKEAAQR 1439

Query: 4479 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4538
            +   I+  ++K + V  K                 F   LQ+    L + +  L      
Sbjct: 1440 VLSQIDVAQKKLQDVSMKF--------RLFQKPANFEQRLQESKMILDEVKMHLPALETK 1491

Query: 4539 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4598
            S+  + V  Q++        ++  + ++  + KTG  +    Q ++   +   + +++  
Sbjct: 1492 SVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLH 1551

Query: 4599 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4658
            + ++  ++ ER + L+   K +++  +  + L EWL  ++  L     +   P  + +++
Sbjct: 1552 YNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEV 1611

Query: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4718
            A  K  QK +  +     +    G +L  KT L      ++D LS L   W  +  ++ E
Sbjct: 1612 AWGKATQKEIEKQKVHLKSITEVGEAL--KTVLGKKETLVEDKLSLLNSNWIAVTSRAEE 1669

Query: 4719 RQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKEL 4778
              N L E       F   +  +  W+ + +  L E +             D  K  + EL
Sbjct: 1670 WLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEK-----KKPQQKEDVLKRLKAEL 1724

Query: 4779 GKRTSSVQALKRSARELIEGSRDD-SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837
                  V + +  A  L+    D     V+ Q+ EL+ R+  +      K  +    L++
Sbjct: 1725 NDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAIS--HRIKTGKASIPLKE 1782

Query: 4838 AEEFHSVVHALLEWL-AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKA 4896
             E+F+S +  LLE L AE +Q     GV   +ED  + + + ++  +K+L ++   L + 
Sbjct: 1783 LEQFNSDIQKLLEPLEAEIQQ-----GVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQR 1837

Query: 4897 TTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIA--KQELL 4954
             T                          R  E +   +Q  Q   +AL  L +  +++ L
Sbjct: 1838 IT------------------------DERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1873

Query: 4955 EALLAWLQWAETT------LTDKDKEVI----PQEIEEVKALIAEHQTFMEEMTRKQPDV 5004
            E    W Q+          L D +K++     P++  ++K +  E Q   EE+   +   
Sbjct: 1874 EISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQA 1933

Query: 5005 DKVTKTYKRRAADPSSLQ 5022
            + +++     A +P+ +Q
Sbjct: 1934 EGLSEDGAAMAVEPTQIQ 1951



 Score =  220 bits (560), Expect = 3e-56
 Identities = 114/240 (47%), Positives = 158/240 (65%), Gaps = 7/240 (2%)

Query: 22  YEDVLERYKDERDKVQKKTFTKWINQHLMKVRK-HVNDLYEDLRDGHNLISLLEVLSGDT 80
           +E+V + Y  ER+ VQKKTFTKW+N    K  K H+ +L+ DL+DG  L+ LLE L+G  
Sbjct: 4   WEEVEDCY--EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQK 61

Query: 81  LPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS 140
           LP+EKG  R H L NV  AL  L+   V LVNI + DI DGN KLTLGLIW IILH+Q+ 
Sbjct: 62  LPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVK 121

Query: 141 DI--HVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI 198
           ++  ++    +  ++++ LL W +Q+T  Y  +   NFTT W DG   NA+IH +RPDL 
Sbjct: 122 NVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLF 181

Query: 199 DMNTVAV-QSNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 256
           D N+V   QS    LEHAF +A  ++G+ +LLDPEDVD + PD+KS++ Y++SL+   P+
Sbjct: 182 DWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQ 241



 Score =  205 bits (521), Expect = 1e-51
 Identities = 284/1564 (18%), Positives = 642/1564 (41%), Gaps = 148/1564 (9%)

Query: 3466 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCN 3525
            ++H  H  Q +++  +     +   K   +S   ++Q  Y+   + + S           
Sbjct: 268  LHHQMHYSQQITVSLAQGYERTSSPKPRFKSYA-YTQAAYVTTSDPTRSPFPSQHLEAPE 326

Query: 3526 AKIFG----EDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQE--------- 3572
             K FG    E EV L  +   + + LS L   + + +   +  +++ V+++         
Sbjct: 327  DKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYM 386

Query: 3573 -DILLRKQNVDQALLNGLELLK--QTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLE 3629
             D+   +  V   L  G +L+   + + DE   +Q+++  + +R++ +   S +    L 
Sbjct: 387  MDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLH 446

Query: 3630 QALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKG--EEASQAQMRPKELKKEAKNNK 3687
            + L   +  +   +EL  WL K E      E + L    E+  +   + K L+++ +  +
Sbjct: 447  RVLMDLQ--NQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQ 504

Query: 3688 ALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQF 3747
              ++SL  +   + E     A   LE+ +    +R+  +      +   +   +L+ Q+ 
Sbjct: 505  VRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRL 564

Query: 3748 DQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGH 3807
             +      +W++E E                     V K  T       +++  L K   
Sbjct: 565  TEEQCLFSAWLSEKEDA-------------------VNKIHTTGFKDQNEMLSSLQKLA- 604

Query: 3808 KIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWL 3867
             ++ A  E++KQSM K     LK  D +  + ++   Q  + ++ ++ F   ++ L   L
Sbjct: 605  -VLKADLEKKKQSMGKLYS--LKQ-DLLSTLKNKSVTQ--KTEAWLDNFARCWDNLVQKL 658

Query: 3868 TETQSIISQLPA---PALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
             ++ + ISQ      P+L   T+ +         +++ +H    +++    PQ       
Sbjct: 659  EKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQ--EELPPPPPQ------- 709

Query: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984
                 +++ +  D+       +++KR   LD  I++   +  + + +L+S E  + R   
Sbjct: 710  -----KKRQITVDS-------EIRKR---LDVDITELHSWITRSEAVLQSPEFAIFRKE- 753

Query: 3985 PPSISAEVEKIKEQISENKNVSVD-MEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
                      +KE+++  +    +   KLQ    + +   E+M+      ++ ++A +++
Sbjct: 754  -----GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMV------NEGVNADSIK 802

Query: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGI 4103
               +Q+   W     L+ ER    L+       F+     L       +++++       
Sbjct: 803  QASEQLNSRWIEFCQLLSER-LNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPS 861

Query: 4104 DPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD 4163
            +P+ +K Q +  +     + GLQ +++    L  + IA   +   P+    +D    A+ 
Sbjct: 862  EPTAIKSQLKICKDEVNRLSGLQPQIE---RLKIQSIALKEKGQGPMF---LDADFVAFT 915

Query: 4164 SLNKAWKDRIDKLEEAMQAA------VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETV 4217
            +  K     +   E+ +Q        ++YQ+ + A+  WV  +  KL+      TD E +
Sbjct: 916  NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975

Query: 4218 KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEE 4277
            +Q++ EL+  +S   +QQ  +  L+   + + KK   E  +   Q    E++  W  L  
Sbjct: 976  EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRK-YQSEFEEIEGRWKKLSS 1034

Query: 4278 RIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVL 4337
            +++    KLE  +  L + Q+ +  L  W+   +  L E+ P  GD + ++ +L +  +L
Sbjct: 1035 QLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLL 1094

Query: 4338 QNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDG 4397
             +D+   Q ++ +VN+ G  +   +  E AS L+ +L+ LN +W ++ ++   RK+ L G
Sbjct: 1095 VSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKG 1154

Query: 4398 ALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETY 4457
             L +      ++ ++ +W+T  E   L        P+  ++ +          + KE   
Sbjct: 1155 GLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKV 1214

Query: 4458 KSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4517
            K L +    ++A+ P  A+  + +++  L   ++ + T+LN +   LEE      E  + 
Sbjct: 1215 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1274

Query: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577
            L+    WL + E  L          + +   +D  +        +  QI  L +T T   
Sbjct: 1275 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1334

Query: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637
               +     LI   L +  SRW ++ +  V R + L+ + + A++  ++   + E L   
Sbjct: 1335 VMDE-----LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFI 1389

Query: 4638 EKSLDSEL-------EIANDPDKIKTQLAQH----KEFQKSLGAKHSVYDTTNRTGRSLK 4686
            +K L + +       ++  +  KI++ L  H    +E +K    K +     ++   + K
Sbjct: 1390 DKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQK 1449

Query: 4687 EKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYR 4746
                      KL D+  + R     +  K    + +L+E+ +   +    L AL      
Sbjct: 1450 ----------KLQDVSMKFR-----LFQKPANFEQRLQESKMILDEVKMHLPAL------ 1488

Query: 4747 VEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR-DDSSW 4805
             E +  E + V   ++  +NL        K L +  S V+ + ++ R++++  + ++   
Sbjct: 1489 -ETKSVEQEVVQSQLNHCVNL-------YKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1540

Query: 4806 VKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVL 4865
            +  ++  L   +  + A    ++ +LE  L+ + +    ++ L EWLA  +  L     +
Sbjct: 1541 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1600

Query: 4866 PDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRAR 4925
                  L + +   K   K++E+++  L   T +G+ +  +      T ++  ++++ + 
Sbjct: 1601 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKE-TLVEDKLSLLNSN 1659

Query: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985
            +  V + A++    L      +    + ++ +  W+  A+T L + +K+   Q+ + +K 
Sbjct: 1660 WIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKR 1719

Query: 4986 LIAE 4989
            L AE
Sbjct: 1720 LKAE 1723



 Score =  184 bits (467), Expect = 2e-45
 Identities = 494/2698 (18%), Positives = 1056/2698 (39%), Gaps = 384/2698 (14%)

Query: 1170 KLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF 1229
            KLK +N  L  T+          T+  EEE +  D  +++  +   K  + ++++++   
Sbjct: 456  KLKELNDWLTKTEE--------RTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRV 507

Query: 1230 HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIG 1289
            ++L   +     + DE    +    L+     E+   L +RW N+    ++R   L+ I 
Sbjct: 508  NSLTHMV----VVVDESSGDHATAALE-----EQLKVLGDRWANICRWTEDRWVLLQDI- 557

Query: 1290 KSLKYYRDTYHP--LDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSK 1347
              LK+ R T        W+ + E    KI     ++   + + L +  +L +++E K+  
Sbjct: 558  -LLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQS 616

Query: 1348 MDECQKYAEQYSATVKDYELQTMT------YRAMVDSQQKSPVKRRRMQSSADLIIQEFM 1401
            M +     +   +T+K+  +   T      +    D+  +   K     S A    Q  +
Sbjct: 617  MGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSL 676

Query: 1402 DLRTRYTALVTLMTQ---YIKFAGDSLKRLEEEEK---SLEEEKKEHVE-KAKELQKWVS 1454
               T    + T+ T+    +K A + L     ++K   +++ E ++ ++    EL  W++
Sbjct: 677  TQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWIT 736

Query: 1455 NISKTLKDAE-----KAGKPPFSKQKISS--EEISTKKEQLSEALQTIQLFLAKHGD--- 1504
                 L+  E     K G     K+K+++   E + K  +L +A ++ Q  + +  +   
Sbjct: 737  RSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGV 796

Query: 1505 -----KMTDEERNE--------LEKQVKTLQESYNLL-FSESLKQLQESQTSGD--VKV- 1547
                 K   E+ N         L +++  L+   N++ F   L+QL++  T+ +  +K+ 
Sbjct: 797  NADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ 856

Query: 1548 -----EEKIVAERQQEYKEKLQGICDLLTQTENRLI--------GHQEAFMIGDGTVELK 1594
                 E   +  + +  K+++  +  L  Q E   I        G    F+  D      
Sbjct: 857  PTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN 916

Query: 1595 KY-------QSKQEELQKDM--------QGSAQALAEVVKNTENFLKENGEKLSQEDKAL 1639
             +       Q++++ELQ           Q +  A+   V+ +E   K +  +LS  D  +
Sbjct: 917  HFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSET--KLSIPQLSVTDYEI 974

Query: 1640 IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1699
            +EQ+L E  ++  Q +L+ +QS       ++T +KE ++K  +     E   K ++  + 
Sbjct: 975  MEQRLGE--LQALQSSLQEQQSGLYY---LSTTVKEMSKKAPS-----EISRKYQSEFEE 1024

Query: 1700 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1759
            +    K       +H Q +E+     Q    +        +   + E DV  +       
Sbjct: 1025 IEGRWKKLSSQLVEHCQKLEE-----QMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG 1079

Query: 1760 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYE 1819
             ++  +K   Q   ++S  Q +  +  S     +K      PE   +L+  +KEL   ++
Sbjct: 1080 DSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWD 1139

Query: 1820 TALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKR 1879
                +   + +      E+      D +E   W+ Q+E+E    +      + L   ++ 
Sbjct: 1140 HMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEE 1199

Query: 1880 QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRF 1939
             K   E+    +  ++ +T S N V+  A   ++              ++++L+  T  +
Sbjct: 1200 MKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ------------EALKKELETLTTNY 1247

Query: 1940 RSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ 1999
            + L   C  L    K L + +  + +    LL+ L+     A+K L+E        ++ +
Sbjct: 1248 QWL---CTRLNGKCKTLEEVWACWHE----LLSYLE----KANKWLNE--------VEFK 1288

Query: 2000 LEETKALQG---QISSQQVAVEKLKKTAEVLLDARGSLLPAKND-------IQKTLDDIV 2049
            L+ T+ + G   +IS    ++E L + +E   +    L     D       I + L+   
Sbjct: 1289 LKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFN 1348

Query: 2050 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLK-------EQGQVPL 2102
             R+ +L +    R + L+ ++  +   +  L  + + +  ++  L        +  Q+P 
Sbjct: 1349 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQ 1408

Query: 2103 NSTALQ-DIISKNIMLEQ---DIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2158
             +  +Q D+ S  I LE+      G++++   +++      +  D S    L  K  +  
Sbjct: 1409 EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFE 1468

Query: 2159 ARFSEASHKHKETLAKMEELKTK--------------VELFENLSE---KLQTFLETKTQ 2201
             R  E+     E    +  L+TK              V L+++LSE   +++  ++T  Q
Sbjct: 1469 QRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQ 1528

Query: 2202 ALTEVDVP-------------------GKDVTELSQYMQESTSEFLEHKKHLEVL----- 2237
             + +                       G  VTE  Q +++      + +K + VL     
Sbjct: 1529 IVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLA 1588

Query: 2238 ---HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVL 2294
                 L K  +  G+PS+    +       K+ ++ +  +K   E   + +  L   + L
Sbjct: 1589 ATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETL 1648

Query: 2295 VKSLKS-----WIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2349
            V+   S     WI  T++          AE+    L + +K  E +      I K     
Sbjct: 1649 VEDKLSLLNSNWIAVTSR----------AEEWLNLLLEYQKHMETFDQNVDHITKWIIQA 1698

Query: 2350 ISLCNLISAVTTPAKAIAAVKSGGAVLNG-----EGTATNTEEFWANKGLTSIKKDMTDI 2404
             +L +  S    P +    +K   A LN      + T        AN+G           
Sbjct: 1699 DTLLD-ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRG----------- 1746

Query: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2464
                +    L++ +I+ELN + + +    +   A +  L+++ +  +  Q+   P + E 
Sbjct: 1747 ----DHCRKLVEPQISELNHRFAAISHRIKTGKASIP-LKELEQFNSDIQKLLEPLEAEI 1801

Query: 2465 VKTQVEQNKSFEAELKQ-NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQEL 2523
             +    + + F  ++ + N   V+EL  +   L +   D  +    K     + +K   L
Sbjct: 1802 QQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNAL 1861

Query: 2524 NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQ 2583
              L   R++K  E S+   Q++     L + L + E  ++ L P   D   +    +++Q
Sbjct: 1862 KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASL-PEPRDERKIKEIDRELQ 1920

Query: 2584 ILLQEFATRKPQYEQLTAAGQGILSRP-------------GEDPSLRGIVKEQLAAVTQK 2630
               +E    + Q E L+  G  +   P              +    R +   Q+  V ++
Sbjct: 1921 KKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREE 1980

Query: 2631 WDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQL 2690
                T  +      ++ + V ST Y + +  +S  L +++  L++    +   + + +Q 
Sbjct: 1981 ----TMMVMTEDMPLEISYVPST-YLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQE 2035

Query: 2691 ETAQKMKQEIQQEKKQIKVAQALCEDLSAL--------VKEEYLKAELSRQLEGILKSFK 2742
            E+ + +K  +QQ   +I +  +  +  +AL        VK +   ++L  Q E + K +K
Sbjct: 2036 ESLKNIKDSLQQSSGRIDIIHS--KKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2093

Query: 2743 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSH-PISAKLDVLESLIK 2801
            D + + +  V+  +        F Q   + + +L   +  +N  H      L  L+  I 
Sbjct: 2094 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2153

Query: 2802 DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERE 2861
              +   +TL           A GE ++ ++  ++ + LQ +L ++   W    KQ+ +R+
Sbjct: 2154 QRQTVVRTLN----------ATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRK 2203

Query: 2862 NKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGE---NSIAKLKSLQKEM 2918
             +L+E      +++  +     W+++  +N+  I   L+P + +     + ++K L +E+
Sbjct: 2204 KRLEEQKNILSEFQRDLNEFVLWLEEA-DNIASIP--LEPGKEQQLKEKLEQVKLLVEEL 2260

Query: 2919 DQHFGMVELLNNTANSLLSVCEIDKEVVTD-ENK-------------------------- 2951
                G+++ LN T   +L    I  E     ENK                          
Sbjct: 2261 PLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2320

Query: 2952 ----SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-----SKRQLQCAKEQLDIH 3002
                 L +K++ + EQL+     L  +  + + + + ++E      + ++    +Q D+ 
Sbjct: 2321 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2380

Query: 3003 DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASD---------SKGTS 3053
            + L    +  K     Q  ++ L+ L  +     RL Q+L  +  D         +  T 
Sbjct: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2440

Query: 3054 DVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAP 3113
             V L  + +  + + +S+   E  S L  ++  +  F     E+    +  D  + S   
Sbjct: 2441 TVTLVTQPVVTKETAISKL--EMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRV 2498

Query: 3114 VGRDAETLQ----KQKETIKAFLKK---LEALMASNDN-ANKTCKMMLATEETSPDLVGI 3165
            +  D E +     KQK T++   ++   LE L+ +  N  NKT      T  T       
Sbjct: 2499 MVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD------ 2552

Query: 3166 KRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVG 3225
               +E +  Q +++ +  Q R +Q+   +K   ++    +E   +L +A    ES     
Sbjct: 2553 --RIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGP 2610

Query: 3226 METETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3285
               + I +++   K   K ++   Q      N L   L++  + +  T+ +    +++NA
Sbjct: 2611 YTVDAIQKKITETKQLAK-DLRQWQTNVDVANDLALKLLRDYS-ADDTRKVHMITENINA 2668

Query: 3286 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV-----ANQKPPSAE-F 3339
             W++++K+V++R A L+E      +F   LE  L+W+ + E        A +K    E  
Sbjct: 2669 SWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDS 2728

Query: 3340 KVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKIL-KQLSLLDSRWEA 3398
            K VK  +++ + LQ  ++        +    +KI  + E +D   +L ++L  ++ +W  
Sbjct: 2729 KGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSE 2788

Query: 3399 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3458
            L  K+      LE  S   ++ H +L+ L  WL   +  L    PIG     +++Q   H
Sbjct: 2789 LRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVH 2848

Query: 3459 KALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSEL 3518
            +A + ++      +   +S  +++++  + +  + ++    + +   +  +E++ + + L
Sbjct: 2849 RAFKRELKTKEPVI---MSTLETVRIFLTEQPLEGLEKL--YQEPRELPPEERAQNVTRL 2903

Query: 3519 LQQALCNAKIFGED-EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3577
            L++         E   +   +W  ++ + L +L     +T+ L     +L++ Q +++  
Sbjct: 2904 LRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL-----DLKLRQAEVIKG 2958

Query: 3578 K-QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQL 3634
              Q V   L++ L              QD LE +KA   +I  L  +V+   + A QL
Sbjct: 2959 SWQPVGDLLIDSL--------------QDHLEKVKALRGEIAPLKENVSHVNDLARQL 3002



 Score = 38.9 bits (89), Expect = 0.14
 Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 27/168 (16%)

Query: 608  VQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMT 666
            +Q+LL W+     +L R    G D P+V+       +VHRA +  E   KE  I     T
Sbjct: 2814 LQELLVWLQLKDDELSRQAPIGGDFPAVQKQ----NDVHRAFKR-ELKTKEPVIMSTLET 2868

Query: 667  APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYD 726
              + LT  + L  LE  Y         + R L        RA N +  L  K+ EEV  +
Sbjct: 2869 VRIFLT-EQPLEGLEKLY--------QEPRELPP----EERAQN-VTRLLRKQAEEVNTE 2914

Query: 727  WSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL 774
            W + N        + A+  R++D+  E ++ +QE  ++L L+   A +
Sbjct: 2915 WEKLNL-------HSADWQRKIDETLERLQELQEATDELDLKLRQAEV 2955


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
            [Homo sapiens]
          Length = 8749

 Score =  318 bits (815), Expect = 9e-86
 Identities = 749/4090 (18%), Positives = 1600/4090 (39%), Gaps = 532/4090 (13%)

Query: 1188 VKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMF 1247
            ++ +E  L   + V   ++N+++   + K +R + + KR+    L   L +   +S    
Sbjct: 334  IEQFERDLTRAQMV---ESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLS---- 386

Query: 1248 KTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQ 1307
                   LD    K+  D++  R  + H+Q+D  L    G   +  Y  +     +  +Q
Sbjct: 387  -------LDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQ 439

Query: 1308 QVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQS------KMDECQKYAEQYSAT 1361
            QV        + + E  K L    +  K    EI   +S        D+ +  AE++   
Sbjct: 440  QVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFV 499

Query: 1362 VKDYELQTMT-------YR-----AMVDSQQKSPVKRRRMQSSADLIIQEFMDL------ 1403
                EL  M        YR      + +S+ KS + +   + S + ++Q ++        
Sbjct: 500  SSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKF 559

Query: 1404 ----RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKT 1459
                   Y  L      Y+K  G S++  E   K + E   +    + E++   S + + 
Sbjct: 560  FEQYEVTYQILKQTAEMYVKADG-SVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEV 618

Query: 1460 LKDAEKAGKPPFSKQ-------KISSEEISTKKE---------QLSEALQTIQLFLAKHG 1503
            + + ++ G    S Q       K+ ++  + KK+         Q   A+     FL +  
Sbjct: 619  ISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETC 678

Query: 1504 DKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVE--------EKIVAER 1555
            D+M   +   L++Q+  L   +  LF E +KQ  ++     +K E             E 
Sbjct: 679  DEMVSRD---LKQQLLLLNGRWRELFME-VKQYAQADEMDRMKKEYTDCVVTLSAFATEA 734

Query: 1556 QQEYKEKLQG-------ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQ 1608
             ++  E L+        +   L   E R+      + I   T  L   +S QEE  K+M 
Sbjct: 735  HKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEE-GKEMF 793

Query: 1609 GSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKV 1668
             +   L E +      +KE    L  E + L+        I  E+L  +       L K+
Sbjct: 794  ATMSKLKEQLTK----VKECYSPLLYESQQLL--------IPLEELEKQMTSFYDSLGKI 841

Query: 1669 --VTTAIKEETEKVAAVKQLEESKTKI-ENLLDWLSNVDKDSERAGTKHKQVIEQNGT-H 1724
              + T ++ E +  A  KQ  +      EN    L+ ++K S+      K V   N   H
Sbjct: 842  NEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSV---QKFVTLSNVLKH 898

Query: 1725 FQEGDGKSAIGEEDEVNGNLLETDVDGQVGT-TQENLNQQYQKVKAQHEKIISQHQAVII 1783
            F +   +  I +      ++++   D +    T   L +++++ +A+ EK++   Q  + 
Sbjct: 899  FDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 958

Query: 1784 ATQSAQVLLEKQGQYLSPEEKEKLQKNMKE-------LKVHYETALAESEKKM-KLTHSL 1835
                 + LL +  ++ S  ++  L   +K        L    +  L E+ +K+ K    L
Sbjct: 959  EKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDL 1018

Query: 1836 QEELE------KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1889
            Q E        K D +   F   +++   EL+  E       G    +K  + F  D   
Sbjct: 1019 QGEAPYHLLHLKIDVEKNRFLASVEECRTELDR-ETKLMPQEGSEKIIKEHRVFFSDKGP 1077

Query: 1890 HKGDLRYITISGNRVLEAAKSCSK---RDGGKVDTSATHREVQRKLDHATDRFRSLYSKC 1946
            H        +   R+    + C K   RD  + DT  T     ++L  A D   S Y K 
Sbjct: 1078 HH-------LCEKRLQLIEELCVKLPVRDPVR-DTPGTCHVTLKELRAAID---STYRKL 1126

Query: 1947 NVLGNNLKDLVDKYQHYED---ASCGLLAGLQACEATASKHLSEPIAVDP--KNLQRQLE 2001
                +  KD   ++  +      +   L G++      + H     AV+     + ++ E
Sbjct: 1127 MEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGE 1186

Query: 2002 ETKALQG------QISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVG--RYE 2053
                L+       ++SS+  A ++  + A+ L  +  +L+   ++++K L +     +Y+
Sbjct: 1187 TLSWLKSRLKVLTEVSSENEAQKQGDELAK-LSSSFKALVTLLSEVEKMLSNFGDCVQYK 1245

Query: 2054 DLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISK 2113
            ++ K+       L+  ++ S  VQ+  +++LD     E+  + Q  +  +    + I +K
Sbjct: 1246 EIVKN------SLEELISGSKEVQEQAEKILD----TENLFEAQQLLLHHQQKTKRISAK 1295

Query: 2114 NIMLEQDIAGRQSSINAM----NEKVKKFMETTDPSTAS-SLQAKMKDLSARFSEASHKH 2168
               ++Q IA  Q     +    +E+++K   T D    S   Q +   ++ R  E    +
Sbjct: 1296 KRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETN 1355

Query: 2169 KETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFL 2228
            KET+ +         LF+  S   +    +  ++L+         +EL Q     T EF 
Sbjct: 1356 KETVVRY--------LFQTGSSHERFLSFSSLESLS---------SELEQ-----TKEFS 1393

Query: 2229 EHKKHLEV-LHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQE 2286
            +  + + V   +L+KE S   L P +K L+ ++  ++ ++ K++EDT++E  + +   + 
Sbjct: 1394 KRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1453

Query: 2287 QLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVN 2346
            + D F    ++L  WI E  K++        A +   S  D +  Q K +++  EI+   
Sbjct: 1454 KWDHFGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKVTIQ--EIESKL 1504

Query: 2347 NSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISH 2406
            +S + L                          E  A +  +F        IK  +T I  
Sbjct: 1505 SSIVGL--------------------------EEEAQSFAQFVTTGESARIKAKLTQIRR 1538

Query: 2407 GYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKM-NKTATKWQQTPAPTDTEAV 2465
              E+L    +     +   LS+ QK +E    + Q + +  +K A   +   + T+T  V
Sbjct: 1539 YGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKV 1598

Query: 2466 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQ 2525
               ++++      L+   + +        +++  +    EA   +Q   +I  + +E   
Sbjct: 1599 ---LQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKE--- 1652

Query: 2526 LTIDRQQKLEESSNNLTQFQTVEAQLKQ---WLVEKELMVSVLG-PLSIDPNMLNTQRQQ 2581
                RQ  LE   N L  +Q +E +L     WL   E   S     +S D   +  + Q 
Sbjct: 1653 ----RQTALE---NLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQL 1705

Query: 2582 VQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2641
            +Q L  E  ++   Y +L    + + S   +D     ++K  L  + ++W  L   ++ R
Sbjct: 1706 IQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK--MMKLHLEQLDERWRDLPQIINKR 1763

Query: 2642 CDWIDQAIVKSTQYQSLLRSLSD--KLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2699
             +++   + +  Q+  LL S S   KL   + + +S +++  H  A+ +  + A     E
Sbjct: 1764 INFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAA----E 1819

Query: 2700 IQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH-------V 2752
            ++ +K +++  Q     L +L + E L   L  + E   + F++  Q  E          
Sbjct: 1820 VESKKGELQSLQGHLAKLGSLGRAEDLHL-LQGKAEDCFQLFEEASQVVERRQLALSHLA 1878

Query: 2753 QHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA 2812
            + LQS  + S   +Q+ +  +A     K E           D++E  + D    +K L  
Sbjct: 1879 EFLQSHASLSGILRQLRQTVEATNSMNKNES----------DLIEKDLNDALQNAKAL-- 1926

Query: 2813 QSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKL--KESLEK 2870
                 E      + +L K Q   K     Q  + +   D    +V+  +N L  K+S   
Sbjct: 1927 -----ESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEAD 1981

Query: 2871 ALK-----YKEQVETLWPWIDKCQNNLEEIKFCLDPAEG-ENSIAKLKSLQKEMDQHFGM 2924
            AL      +++Q E L   I+  +   ++ +      +  +  +     L+ E++ H   
Sbjct: 1982 ALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHE 2041

Query: 2925 VELLNNTANSLLS-----VCEIDKE-----VVTDENKSLIQK--------VDMVTEQLHS 2966
            +  L + A  +         E+D+E     V  D+ K LI +        +D++ E  + 
Sbjct: 2042 LCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL 2101

Query: 2967 KKFC---LENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQA-YSNKYLTMLQTQQ 3022
            K      LEN +        V++ + +  +  K     H++  ++  Y  K L    ++ 
Sbjct: 2102 KSAVSKVLENASSVI-----VTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKG 2156

Query: 3023 KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQV-ETIAQEHSTLSQQVDEKCSFLE 3081
            K L +     +L K  + D  +  +D + T D  L V E + +    L   +      L 
Sbjct: 2157 KHLLS-----ELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2211

Query: 3082 TKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMAS 3141
            T+ +  G   N + +M    +  D+ L       R  E L++ +  +K    +LE L + 
Sbjct: 2212 TRDEIEGWSNNCVPQMAENISNLDNHL-------RAEELLKEFESEVKNKALRLEELHSK 2264

Query: 3142 NDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQ-------AREEQVEGTI 3194
             ++  +  K +    ET PDL  I+ DL    +   ++ + A+       A+  QVE  I
Sbjct: 2265 VNDLKELTKNL----ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFI 2320

Query: 3195 KRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQ 3254
              +  +++K++E    L    ++E  +             L   K  QKE    LQ +Q 
Sbjct: 2321 NDITTWFTKVEES---LMNCAQNETCEA------------LKKVKDIQKE----LQSQQS 2361

Query: 3255 DVNWLGQGLIQSAAK--STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQ 3312
            +++   + L     K  S   + L   +  +  + + +++  ++  A LQE+L     F 
Sbjct: 2362 NISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFS 2419

Query: 3313 DALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEK 3372
            ++++    W +  +         + + KV++A++ + + +   + D +S ++ + +EG+ 
Sbjct: 2420 ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQT 2479

Query: 3373 IATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLT 3432
            +           I +Q++  +  ++A L +     + L+  +     F +    LN W+ 
Sbjct: 2480 LYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIH 2539

Query: 3433 TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSR---- 3488
             +E+R  N E +G     + E+       ++++      L + ++  +SL  LS R    
Sbjct: 2540 EMEERF-NTENLGESKQHIPEK-------KNEVHKVEMFLGELLAARESLDKLSQRGQLL 2591

Query: 3489 --EDKDMVQSKLDFSQVW--YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3544
              E     Q     SQ+   +  +   +  +    Q AL   +   E    +  W+  + 
Sbjct: 2592 SEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2651

Query: 3545 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK----QNVDQALLNGLELLKQTTGDEV 3600
            D+L+       S + L K+ S++    +DILL K      ++ A+  G + L+ +  +  
Sbjct: 2652 DRLACAESTLGSKDTLEKRLSQI----QDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ 2707

Query: 3601 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYE 3660
             +IQ +LE +K  + DI   S     TLE  +           +L  W++ V+ ++    
Sbjct: 2708 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI---- 2763

Query: 3661 TQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED- 3719
                  E   Q Q   KE      + +++L    + + AL  L+  ++RE  EK   E  
Sbjct: 2764 ------EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA-KSRELYEKTEDESF 2816

Query: 3720 --------NERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI 3771
                      ++  +     +K+ +++  +     +  A      W+   +++L    D+
Sbjct: 2817 KDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDM 2876

Query: 3772 RLEQDQTSAQLQVQKTF--TMEILRHK---------DIIDDLVKSGHKIMTACSEEEKQS 3820
              +   T  +L   K    + EI   +         ++  +   SG ++M    +  +  
Sbjct: 2877 SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRAD 2936

Query: 3821 MKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAP 3880
             K+  D V +    +  + S+  L  +     V Q  +  E+    L      ++ L   
Sbjct: 2937 WKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGK 2996

Query: 3881 ALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYV 3934
              + E + +   + +++ + + + +P  + +     +L   S       G+   + ++Y 
Sbjct: 2997 NTD-EEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY- 3054

Query: 3935 AADTLYSQIKEDVKKRAVALDEAISQS-TQFHDKIDQILESLERIVERLRQPPSISAEVE 3993
              + L  Q  +  + +   L +   ++   F   +     +  +  +  +    +S  ++
Sbjct: 3055 --NCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQ 3112

Query: 3994 KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIW 4053
            KI+E +SE++N    +  +    E L      ++ +         AK +Q K+      W
Sbjct: 3113 KIQEFLSESENGQHKLNMMLSKGELL----STLLTKE-------KAKGIQAKVTAAKEDW 3161

Query: 4054 ENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQE 4113
            +N H+ + ++E+ L ++    + F      +   +  T+  + +  +   D    +++Q+
Sbjct: 3162 KNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQ 3221

Query: 4114 AAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4173
              +++ EEI   + +L+ +     +L    G+      +  + +L+S + +L+   K+++
Sbjct: 3222 KLQSVLEEIHCYEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKV 3279

Query: 4174 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4233
             +L+  +    Q+  G++ + DW+  A   L S     +D   +  +  +L+   S   +
Sbjct: 3280 SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQE 3339

Query: 4234 QQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL 4293
            ++I+M+ +  + E +L+  + E    T+Q  L  +K +W SL    I  + +LEGAL   
Sbjct: 3340 KEIQMKMIVTRGESVLQNTSPEGIP-TIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKW 3398

Query: 4294 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNK 4353
              +Q  + +   W+   E  L+E +    + +     L K  +L  +VL++ S +E +  
Sbjct: 3399 TSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEV 3458

Query: 4354 AGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQ 4413
             G  + E          Q +L+ L +R++ + E+ ++   + +  +R  + +  +++  +
Sbjct: 3459 KGAGMTEHYV------TQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFE 3512

Query: 4414 QWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK 4473
             WL   +  L     L G   T +  L    E+       +    S++   + ++     
Sbjct: 3513 VWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIP 3572

Query: 4474 SAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLN 4533
             AE   D+ + +L++ W++ + +L+E +T+    +N         Q    WL  AE+   
Sbjct: 3573 QAE---DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE--- 3626

Query: 4534 VASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLI 4593
                               K +  EV ++R+++ E+      +   S     +  +    
Sbjct: 3627 -------------------KKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ--AT 3665

Query: 4594 SVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDK 4653
             + SR++ ++ +++E+ + L++  +  ++   + S   +W   + K+  +   +A   DK
Sbjct: 3666 QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKN---VATKIDK 3722

Query: 4654 IKT-----QLAQHKEFQKSLGAKHSVYDTTNRTG-RSLKEKTSLADDNLK--LDDMLSEL 4705
            + T     +L   +   K +   HS+  +    G R++K       + L+  + D + +L
Sbjct: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQL 3782

Query: 4706 RDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVM 4765
            ++   T+     +    LE+ L  + +F+D  +AL  W+   +  L   +    ++    
Sbjct: 3783 KELTSTV----RKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK 3838

Query: 4766 NLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSI 4825
              +  +K+ Q+ +     SV++++     L+E  +D +  +K ++ +L + ++ +C++  
Sbjct: 3839 AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT--LKDKIDQLQSDYQDLCSIGK 3896

Query: 4826 SKQTRLEAALRQAEEFHSVVHALLEWLA---EAEQTLRFHGVLPDDEDALRTLIDQHKEF 4882
            +    +     +          L+   A   +A+     H  L   +D+   +    +  
Sbjct: 3897 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956

Query: 4883 MKKLEEKRAELNKATTMGDTV------LAICHPD-------------SITTIKHWITI-- 4921
             + LE    EL K  +  DT+      L+   PD             +I  +KH+  +  
Sbjct: 3957 YQSLEH---ELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE 4013

Query: 4922 -------------------IRARFEEVLAWAKQHQQRLASA---LAGLIAKQELLEALLA 4959
                               ++   +++    +  +Q+L  A     G    + L   L  
Sbjct: 4014 QARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWI 4073

Query: 4960 WLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDV----DKVTKTYKRRA 5015
            +LQ A+  L +  +     E+   + ++++ + F++++  KQ  V    +KV K  K+  
Sbjct: 4074 YLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEE 4133

Query: 5016 ADPSSLQSHI 5025
            +      +H+
Sbjct: 4134 SPEHKEINHL 4143



 Score =  317 bits (813), Expect = 2e-85
 Identities = 710/4024 (17%), Positives = 1549/4024 (38%), Gaps = 512/4024 (12%)

Query: 1285 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1341
            L   G  ++Y     + L++ I   +  Q + ++     +   A QL   +QQK     I
Sbjct: 1235 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1292

Query: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1400
              K+  + +    A+Q    + D   + +    + +D  ++S   R R +    + ++++
Sbjct: 1293 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1349

Query: 1401 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS--- 1457
                T    +V    +Y+   G S +R      SLE    E +E+ KE  K   +I+   
Sbjct: 1350 ERFETNKETVV----RYLFQTGSSHERFLSFS-SLESLSSE-LEQTKEFSKRTESIAVQA 1403

Query: 1458 -KTLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEE 1510
               +K+A +    P +KQ      K   E++   ++ L E ++T+++   K      D  
Sbjct: 1404 ENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHF 1458

Query: 1511 RNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLL 1570
             +  E     + E       + L  L+ S ++ D+++ +  +    QE + KL  I  L 
Sbjct: 1459 GSNFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLE 1511

Query: 1571 TQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKE 1627
             + ++  + +   E+  I     ++++Y  +  E  + ++G+    L++  K  EN  K 
Sbjct: 1512 EEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKI 1571

Query: 1628 NGEKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT------------- 1671
                   EDK  +  K+  +     K  Q ++   Q+ + L   +T              
Sbjct: 1572 QQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDS 1631

Query: 1672 ------AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHF 1725
                  A++++ E +  +++ +E +T +ENLL     ++K+           +    T  
Sbjct: 1632 CVQEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWL 1678

Query: 1726 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1785
            + G+ K++  E D              +   +  +  + Q ++A   +++SQ      A+
Sbjct: 1679 ERGEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------AS 1718

Query: 1786 QSAQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFD 1843
              +++L  K+  +   S ++ + ++ ++++L   +        K++    S+  E ++FD
Sbjct: 1719 FYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFD 1778

Query: 1844 ADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNR 1903
                 F  W++    EL+        I      L R K  + +V S KG+L+  ++ G+ 
Sbjct: 1779 ELLLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHL 1834

Query: 1904 VLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKY 1960
                          K+ +     ++      A D F+       V+      L  L +  
Sbjct: 1835 A-------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL 1881

Query: 1961 QHYEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEK 2019
            Q +   S G+L  L Q  EAT S + +E   ++ K+L   L+  KAL+    S  V+++ 
Sbjct: 1882 QSHASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDG 1935

Query: 2020 LKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDG 2079
            +   A+  L    S    +   + T D + G  E +   +  +  +         + QD 
Sbjct: 1936 ILSKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQ 1993

Query: 2080 LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFM 2139
             +E+L  + ++E    ++        ALQ  +     LE ++   +  +  + +K K+  
Sbjct: 1994 KEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA 2053

Query: 2140 ETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETK 2199
            +  D + A  +  ++  L   + +      E   +   L   +  ++NL   +   LE  
Sbjct: 2054 QK-DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENA 2112

Query: 2200 TQAL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEIS 2245
            +  + T   +  KD  +L               Y Q+    F    KHL    S LK+I 
Sbjct: 2113 SSVIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIH 2167

Query: 2246 SHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLK 2299
            S     + +D    ++K  ++S+K +E  D ++      + V S +++++ +        
Sbjct: 2168 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------N 2221

Query: 2300 SWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISA 2358
            + + +  + +  +     AE+L K  E   K +   +L+  E+  KVN+    L  L   
Sbjct: 2222 NCVPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKN 2274

Query: 2359 VTTP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKD 2400
            + TP                AK I  V  G  + +    +T  E+F  +     T +++ 
Sbjct: 2275 LETPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEES 2333

Query: 2401 MTDISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2459
            + + +       L  +KD   EL ++ S +   QE  +++ +        +     T   
Sbjct: 2334 LMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLI 2393

Query: 2460 TDTEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKL 2493
               EAV     KTQ    +S E    +++ + QE                     L+ KL
Sbjct: 2394 KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKL 2453

Query: 2494 TEL----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDR 2530
             +L                + +   T  A   KQ+       +T+ + ++Q   +  +  
Sbjct: 2454 HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKD 2513

Query: 2531 QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQE 2588
            +Q L++ ++ L  F+    +L  W+ E E   +   LG           +  +V++ L E
Sbjct: 2514 KQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGE 2573

Query: 2589 FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQA 2648
                +   ++L+  GQ +LS  G      G +  QL    Q    +T +    C     A
Sbjct: 2574 LLAARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VA 2629

Query: 2649 IVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIK 2708
            + +    +  L+S+   +  + ++L+ + +     D + ++L   Q +   + + + ++K
Sbjct: 2630 LQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVK 2687

Query: 2709 VAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2767
            +  A+ +   AL    +  +  +  QLE + + + D+   + +    L+S  +  + + +
Sbjct: 2688 LNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVE 2747

Query: 2768 MSRDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYE 2818
                 + W+++   +Q   HP+  +         LD L+S++ + +D ++ L        
Sbjct: 2748 RKNQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------H 2798

Query: 2819 KTIAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQ 2877
            + IA+   L  KT+  S K   Q +L   KT ++      KE+  K++E ++  L Y + 
Sbjct: 2799 RLIAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDA 2855

Query: 2878 VETLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMD 2919
            V     W+                    Q  L +IK  +D  E G + +++++SL  E+ 
Sbjct: 2856 VHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVK 2915

Query: 2920 QHFGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 2977
            Q+      EL++    +L +  +  ++ V      L   V  +          +  + Q 
Sbjct: 2916 QNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQA 2975

Query: 2978 FKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKR 3037
             ++F  + K   +QL   + +    + +       + L  LQ  +   + LK Q++   R
Sbjct: 2976 LEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCR 3035

Query: 3038 LAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREM 3097
             ++DL   +    G          + +E++ L  Q  + C   E  LQ         +  
Sbjct: 3036 FSRDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRF 3076

Query: 3098 FSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEE 3157
               F +F   L +          + +    +   L+K++  ++ ++N      MML+  E
Sbjct: 3077 RKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE 3136

Query: 3158 TSPDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILL 3211
                L+      GI+  + A  +           +E  +E    ++++F    +     L
Sbjct: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196

Query: 3212 QKAEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQ 3265
             K E+  HE S     +  +   QQ     + +    EP    L+ K Q + W GQ    
Sbjct: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ---- 3251

Query: 3266 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDT 3325
            +A+KS       H +  +++++  L+    ++ ++L   +    +F   ++ L  WM D 
Sbjct: 3252 AASKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDA 3306

Query: 3326 EELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI 3385
              ++ +   P+++  V+ ++  + + L  +  +++  +++I   GE +     P     I
Sbjct: 3307 IHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTI 3366

Query: 3386 LKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3445
             +QL  +   W +LL+       QLEG       + + +   + W+ ++E  L   E   
Sbjct: 3367 QQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQH 3426

Query: 3446 TQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY 3505
             +       + + K L +++++++  L      G  +       +  + Q +L   Q  Y
Sbjct: 3427 AELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERY 3480

Query: 3506 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS 3565
              IQE++       ++ +   + +  D      WL +  +KL + SV +         ++
Sbjct: 3481 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THET 3537

Query: 3566 ELRVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTD 3623
             LR LQE  L       QALLN  L   +      +   +D+ LE+++  ++      ++
Sbjct: 3538 TLRDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSE 3595

Query: 3624 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3683
                    +   R +    +++  WL   E +    E    + +E  +   R +E+  E+
Sbjct: 3596 TRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYR-DEVEEVGARAQEILDES 3654

Query: 3684 KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILR 3743
              N  +     +++S                       RY+ +   + ++++ ++  I  
Sbjct: 3655 HVNSRMGCQATQLTS-----------------------RYQALLLQVLEQIKFLEEEIQS 3691

Query: 3744 SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKDI 3798
             ++ + +  +   W   T K   +   +  + D+    +  +K  T+E+L     +   +
Sbjct: 3692 LEESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSL 3748

Query: 3799 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3858
            +    + G + +    E E + ++K++   ++    +     + ++ LE+   L  +F +
Sbjct: 3749 LKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSD 3808

Query: 3859 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3918
              + L  W+               EY+ +    EE +     + E K  + K       +
Sbjct: 3809 KCKALTQWIA--------------EYQEILHVPEEPKME---LYEKKAQLSKYKSLQQTV 3851

Query: 3919 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERI 3978
            L   P                     + V+++  AL E + Q     DKIDQ+    + +
Sbjct: 3852 LSHEPSV-------------------KSVREKGEALLELV-QDVTLKDKIDQLQSDYQDL 3891

Query: 3979 VERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS 4038
                                 S  K +  ++   +     L+ +G+ +I +         
Sbjct: 3892 C--------------------SIGKAMMEEIAGFEDRLNNLQMKGDTLIGQC-------- 3923

Query: 4039 AKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIKDT 4091
            A  +Q KL Q      N+H  ++  +     +   A++ +         H+S   T++  
Sbjct: 3924 ADHLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 3977

Query: 4092 QDFIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPDKP 4149
            Q ++  ++ P ++PS  +     AE I++      LQE+    ++L   L + C +    
Sbjct: 3978 QAWLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLSNA 4031

Query: 4150 IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP 4209
             VK +  ++     ++ +    ++ + +   Q   + +     ++ ++  A  +L +M  
Sbjct: 4032 SVKTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKR 4087

Query: 4210 IGTDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLME 4267
              ++LE    +  + ++K F  +   +Q  +  +  +   L KK  EES +H   + L +
Sbjct: 4088 RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHLND 4145

Query: 4268 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
                W  L  +  N   + E  L     +   ++ +  +L               +  A+
Sbjct: 4146 Q---WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAV 4202

Query: 4328 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4387
             +E  K   L   +   +  +E +      +IE    ++   ++ +   L QRW  + + 
Sbjct: 4203 HLEALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260

Query: 4388 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVC 4447
             +++ Q     L +        ++L +W  + + ++  +      P+ A+  L  H+ +C
Sbjct: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC 4320

Query: 4448 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEA 4507
            +  EAK+   KSL++   +++A    +    I + +++ +     +   + +R+  L +A
Sbjct: 4321 SELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKA 4380

Query: 4508 LNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQII 4567
            L+   +F  ++    + + Q E+ +       L+ D V  Q+   K     + +++ ++ 
Sbjct: 4381 LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4440

Query: 4568 ELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAW 4627
             L   G  L     +Q+   +   L  +QS ++ V+Q+   R + L+      K F E +
Sbjct: 4441 GLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF 4500

Query: 4628 SKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4687
             K   WL++++     E+ + N+  ++ TQLA+++   +      ++  T  RTG+++  
Sbjct: 4501 DKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILP 4560

Query: 4688 KTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRV 4747
              +  D +  L + L+ L  +++ I   + ++  K++EA+L   ++   ++     L  +
Sbjct: 4561 SLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSEL 4619

Query: 4748 EPQLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS- 4804
            E Q      V  D  ++  ++L D  +A   E+     +V  L +      EG R     
Sbjct: 4620 EAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTGQP 4675

Query: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLRFH 4862
            W   +M  L T +  +   +  + + LE      +E   +   L   L   + EQ+    
Sbjct: 4676 WQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE 4735

Query: 4863 GVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4922
              LP +E      +  +      L++    L + T   + +     P +    +H I   
Sbjct: 4736 ETLPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSW 4790

Query: 4923 RARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEVIP 4977
            +   + + +   +      S +   I  Q  +   L WL+  +  L+     D + + I 
Sbjct: 4791 QGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQ 4850

Query: 4978 QEIEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5036
            +EI +++    E Q+ +  M      + +K TK  +  +AD     + +  LD       
Sbjct: 4851 EEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL 4910

Query: 5037 RFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANF 5096
            R   ++L    SQ Q             ++ QV+  A       ND L+  +EL + A  
Sbjct: 4911 RTRQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLAGN 4950

Query: 5097 DFDI 5100
              D+
Sbjct: 4951 GLDV 4954



 Score =  313 bits (801), Expect = 4e-84
 Identities = 865/4757 (18%), Positives = 1840/4757 (38%), Gaps = 697/4757 (14%)

Query: 605  MKFVQDLLNWVDEMQVQLDR-TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEI 663
            +KF+++ +  ++E +  L   ++W        S  +N KNV   I++ ++ +   K+  +
Sbjct: 3682 IKFLEEEIQSLEESESSLSSYSDWYG------STHKNFKNVATKIDKVDTVMMGKKLKTL 3735

Query: 664  QMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEV 723
            ++           L  +E  ++ L +     ER +  L    +    + I  + ++ +E+
Sbjct: 3736 EVL----------LKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKEL 3785

Query: 724  AYDWSERNTNIARKKDYH-----AELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEA 778
                + R  ++  +K  H     ++  + L Q     + +  + E+  +E +  +  +  
Sbjct: 3786 TS--TVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3843

Query: 779  YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS 838
            Y++  QT    +L     V+   ++  A  E   D       L++  D +Q  Y      
Sbjct: 3844 YKSLQQT----VLSHEPSVKSVREKGEALLELVQDVT-----LKDKIDQLQSDY------ 3888

Query: 839  SIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI-------- 890
                 +DL        EE+  ++  + NL  K  T+I     +    LK ++        
Sbjct: 3889 -----QDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTK 3943

Query: 891  -PIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAV 949
                AIC   Q    +Y+  E  L  +  R            A+ P +  +  PP   A 
Sbjct: 3944 DSYSAICSTAQ---RMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAE 4000

Query: 950  DLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVL 1009
             +     +Q ++   L  ++   +  + S   L N          AS+KT    + QQ  
Sbjct: 4001 AI-----KQVKHFRALQEQARTYLDLLCSMCDLSN----------ASVKTTAK-DIQQTE 4044

Query: 1010 SNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAERE--EQEESVYNL 1067
              ++ +       +Q        +I  L+ E+ +  Q   + L++ +R   E E ++   
Sbjct: 4045 QTIEQKLVQAQNLTQ-----GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQN 4099

Query: 1068 YISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLK--KELERLKDDLGT 1125
             +S+V++   +L++ +  +          + + E V ++T++E+    KE+  L D    
Sbjct: 4100 MVSQVKDFVKKLQSKQASV----------NTIIEKVNKLTKKEESPEHKEINHLND---- 4145

Query: 1126 ITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAE 1185
                  ++      S+++   R E     ++ +   ++   +++K  T    L  + A  
Sbjct: 4146 ------QWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4199

Query: 1186 ALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDE 1245
              V L                        LK+    + E++     L+D+ QK       
Sbjct: 4200 TAVHL----------------------EALKKLALALQERKYAIEDLKDQKQK------- 4230

Query: 1246 MFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDW 1305
            M +     D +    KE+   L +RW  +   I  +++      + L   +  +  L +W
Sbjct: 4231 MIEHLNLDDKELV--KEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEW 4288

Query: 1306 I--QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVK 1363
               QQ    +   Q   P+ ++ L   L     + SE+E KQ  +    K A++  A + 
Sbjct: 4289 AEEQQPNIAEALKQSPPPDMAQNL---LMDHLAICSELEAKQMLLKSLIKDADRVMADLG 4345

Query: 1364 DYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD 1423
              E Q +  +A+ D+Q         +   +DL+ Q     R      ++  TQ++     
Sbjct: 4346 LNERQVIQ-KALSDAQS-------HVNCLSDLVGQR----RKYLNKALSEKTQFLMAVFQ 4393

Query: 1424 SLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIST 1483
            +  ++++ E+ +    +EH+     L   VS   KT K A+       +  K    E++ 
Sbjct: 4394 ATSQIQQHERKIMF--REHICL---LPDDVSKQVKTCKSAQ-------ASLKTYQNEVTG 4441

Query: 1484 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1543
               Q  E ++ +           T++E++E+  +++ LQ  Y+ +  +   +LQE     
Sbjct: 4442 LWAQGRELMKEV-----------TEQEKSEVLGKLQELQSVYDSVLQKCSHRLQE----- 4485

Query: 1544 DVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEEL 1603
               +E+ +V+ +   +KE     C  L Q +  ++   E  ++ + + EL    +K + +
Sbjct: 4486 ---LEKNLVSRKH--FKEDFDKACHWLKQAD--IVTFPEINLMNESS-ELHTQLAKYQNI 4537

Query: 1604 QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK 1663
             +        L  + +  +  L      L++ D + + +KLN       Q N+    +K 
Sbjct: 4538 LEQSPEYENLLLTLQRTGQTILPS----LNEVDHSYLSEKLNALP---RQFNVIVALAKD 4590

Query: 1664 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGT 1723
            +  KV   AI    E  + ++   +S +++E     +S V  D          +  +   
Sbjct: 4591 KFYKV-QEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD----------LAVEEAL 4639

Query: 1724 HFQEG-----DGKSAIGEE-DEVNGNLLETDVDGQVGTTQENLN--QQYQKVKAQHEKII 1775
              Q+G     D  + +GE  DE+N         GQ     + L+    Y ++K Q E+ +
Sbjct: 4640 SLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRV 4699

Query: 1776 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1835
            S    ++  T SA    EK  Q L     E+  K++KE +         +E+K+K+ HSL
Sbjct: 4700 S----LLEDTTSAYQEHEKMCQQL-----ERQLKSVKEEQSKVNEETLPAEEKLKMYHSL 4750

Query: 1836 QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLR 1895
               L              Q S   L+ +    +D+   +  L  +K+    + S +G+L+
Sbjct: 4751 AGSL--------------QDSGIVLKRVTIHLEDLAPHLDPLAYEKA-RHQIQSWQGELK 4795

Query: 1896 YITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1955
             +T   + + E    C  R    +D      E+ R LD    R ++  S    L  NL+D
Sbjct: 4796 LLT---SAIGETVTECESRMVQSIDFQT---EMSRSLDWLR-RVKAELSGPVYLDLNLQD 4848

Query: 1956 LVDKYQ----HYED--ASCGLLAGLQACEATASKHLSEPIAVDPKN-----------LQR 1998
            + ++ +    H E+  +S  ++  L   E        E I+ D ++           +Q 
Sbjct: 4849 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4908

Query: 1999 QLEETKALQGQISSQ--------QVAVEKLKKTAEVLLDARGSL---------------- 2034
             L   +A   +I SQ        Q A + L+   E+L  A   L                
Sbjct: 4909 ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFF 4968

Query: 2035 ---------LPAKNDIQKTLDDIV---GRYEDLSKSVNE---------RNEKLQITLTRS 2073
                     L   + +  TLD ++   G+ EDL + V           R+   Q+ L + 
Sbjct: 4969 STEDQFHSNLEELHSLVATLDPLIKPTGK-EDLEQKVASLELRSQRMSRDSGAQVDLLQR 5027

Query: 2074 LSVQ-----DGLDEMLDWMGNVESSLKEQGQVPLNST-ALQDIISKNIMLEQDIAGRQSS 2127
             + Q        +E+++ M + E  L E   +  +S+   ++ +S++  L   +      
Sbjct: 5028 CTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEK 5087

Query: 2128 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE---------- 2177
            I A+ EK  +  +T + ++ ++L   M  +  R++      ++    +E+          
Sbjct: 5088 IVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNN 5147

Query: 2178 -LKTKVELFENLSEKL---QTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKH 2233
             +K   E+ + L +KL        +K + LT ++     V EL Q  Q+S    L  +  
Sbjct: 5148 KVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ--QQSALGMLRQQTL 5205

Query: 2234 LEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQV 2293
                 S+L++  +   P ++  ++++   +  +   M++ +K   + V    +  +  + 
Sbjct: 5206 -----SMLQD-GAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET 5259

Query: 2294 LVKSLKSWIKETTK----------------KVPIVQPSFGAEDLGKSLEDTKK------- 2330
             + S+K W++ET +                ++ + + +   +++ K  E+ K+       
Sbjct: 5260 QINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYT 5319

Query: 2331 -LQEKWSLKTPEI------------------------QKVNNSGISLCNLISAVTTPAKA 2365
             L  + SL+  E+                        Q+++     L   ++ + T  KA
Sbjct: 5320 ILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKA 5379

Query: 2366 ----IAAVKSGGAVLNGEGTATNT---------EEFWANKGLTS--IKKDMTDISHGYED 2410
                +   K+   VL  E    N+         ++F    G     + K +  ++  ++ 
Sbjct: 5380 KTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQ 5439

Query: 2411 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTA---TKWQQTPAPTDTEAV-K 2466
                 ++++++LN   S L++  E    +++W++K    A     W       +   + +
Sbjct: 5440 TIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQ 5499

Query: 2467 TQVEQNKSFEAELKQNVNKVQELK-----DKLTELLEENPDTPEAPRW--KQMLTEIDSK 2519
            T +E++K  ++EL+    K+Q L      +K+++ + E     E  R   K  L  +   
Sbjct: 5500 TLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDA 5559

Query: 2520 WQELNQLTIDR---QQKLEESSNNLTQFQTVEAQLKQWLVEKELMVS------------- 2563
             +++ +   +    Q  LE++   LT  +     LK+ L  ++ ++S             
Sbjct: 5560 AKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ 5619

Query: 2564 -----------VLGPLSIDPNMLNTQRQQVQI---------LLQEFATRKPQYEQ----- 2598
                       V+  L +    L  Q +  ++         ++Q    +  QYEQ     
Sbjct: 5620 LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHL 5679

Query: 2599 ---LTAAGQGILSRPGEDPSLRGIVK-----EQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2650
               +  A + I  +P    +++ +       E+LA   + +      L+ +C  +     
Sbjct: 5680 QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAK 5739

Query: 2651 KSTQYQSL--LRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIK 2708
             +T   ++  +  L++   DLD +L  +   S HP  +         +   + +E  +  
Sbjct: 5740 HATMLLTVTEVEGLAEGTEDLDGELLPT--PSAHPSVVMMTAGRCHTLLSPVTEESGEEG 5797

Query: 2709 VAQAL-----CEDLSALVKEE--------YLKAELSRQLE----------GILKSFKD-- 2743
                +     C   S +   +        Y +A  + +L+             + F +  
Sbjct: 5798 TNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPG 5857

Query: 2744 VEQKAENHVQHLQSACAS-SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2802
            +E  A   +  LQ +  +  +   +  R     L+ +++ Q+    IS K++ +E  + +
Sbjct: 5858 LEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSE 5917

Query: 2803 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQ--------------------GSEKAALQLQ 2842
              +  ++   +S M E      E L+L+ +                     +E+ ALQ  
Sbjct: 5918 SPEPGRS--PESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 5975

Query: 2843 LNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW---IDKCQNNLEEIKFCL 2899
            L  +     T   +   +   L+E L   L+ + Q + L  +    D+  + L   K  L
Sbjct: 5976 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6035

Query: 2900 DPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDM 2959
            D A        L   ++ MD    +++  N        V  + +  V +EN  L  K   
Sbjct: 6036 DTA--------LSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHT 6087

Query: 2960 V--TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCA---KEQLDIHDSLGSQAYSNKY 3014
                EQL  K   L  +     E Q    + +  +Q     KE+ D+  +        ++
Sbjct: 6088 KDEAEQLAGK---LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEW 6144

Query: 3015 LTMLQTQ--QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ 3072
            L   +T   Q+   +L+ Q +L + LA+   +  S +    ++L+Q       HS     
Sbjct: 6145 LAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQ-------HSAAETS 6197

Query: 3073 VD--EKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKA 3130
             D  EK   L  +L   G   +   +M  ++     E  +            KQK     
Sbjct: 6198 GDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFST------------KQKLLQNV 6245

Query: 3131 FLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQV 3190
              ++ E ++ S  N   +   +   +  + D   +   L+ L++   ++  ++   + Q 
Sbjct: 6246 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ- 6304

Query: 3191 EGTIKRLEEFYSKLKEFSILLQKAEEH---EESQGPVGMETETINQQLNMFKVFQKEEIE 3247
              +I   ++ Y  +   S  L   EE      +  P   ET   NQ+     +  K+  E
Sbjct: 6305 --SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQE-----ILAKDIKE 6357

Query: 3248 PLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLH 3307
              +   ++ N   Q   ++     +   +E  L  +  R   L+  V QR  Q++E L  
Sbjct: 6358 MSEEMDKNKNLFSQAFPENG---DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQ 6414

Query: 3308 CGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIK 3367
               FQ+ L+ L + + D + ++  QK  +   + V  QI+  +  +  L +  + +  +K
Sbjct: 6415 ILNFQNDLKVLFTSLADNKYIIL-QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELK 6473

Query: 3368 REGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPL 3427
            R G+K+    +P+     +++LS L   ++ L+    +R   L     +  Q+   L+ L
Sbjct: 6474 RRGDKLQVE-QPS-----MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDL 6527

Query: 3428 NEWLTTIEKRLVNCEPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSL--KV 3484
             + L T ++++   + I   + + +++ + +HK     + +H       + + ++L  K+
Sbjct: 6528 ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH-------MILTETLFRKI 6580

Query: 3485 LSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVH 3544
            +S    K+        +Q     + +++H R   L+  L       ED+ EL   L  V 
Sbjct: 6581 ISFAVQKETQFHTELMAQA--SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVE 6638

Query: 3545 DKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQ 3604
              +  + + + + + L  + +  + L+  +   +  + Q L +G  LL   +  +   ++
Sbjct: 6639 SSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LE 6695

Query: 3605 DKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQ-V 3663
             +L  +   +   T   +     LE  L+   R  S   +L  WL   +  L  +  Q V
Sbjct: 6696 SQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV 6755

Query: 3664 LKGEEASQAQMRPK---ELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3720
               +E    +       E  KE     +L  S+    + LL L          ++   D+
Sbjct: 6756 TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDS 6815

Query: 3721 ERYRLVSD--TITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI---RLEQ 3775
            +   L+++   + +K+ ++    L S+    A    +SWI+  E  +    D     +  
Sbjct: 6816 QWTDLLTNIPAVQEKLHQLQMDKLPSRH---AISEVMSWISLMENVIQKDEDNIKNSIGY 6872

Query: 3776 DQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK----KKLDKVLKN 3831
                  LQ  K F ++I   K +  D V      +++   E K+S K    ++L  + K+
Sbjct: 6873 KAIHEYLQKYKGFKIDI-NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKS 6931

Query: 3832 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3891
            +  +  + +E+   LE      +++    + L  W  ETQ    +      +  +++   
Sbjct: 6932 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNAL 6990

Query: 3892 EEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQ--------EKYVAADTLYSQI 3943
            ++ + L +LI   +  ++K+ + G  L++    +  SI         + +   D +  Q+
Sbjct: 6991 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7050

Query: 3944 KEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENK 4003
            K  +K     LD+  S    F DKI+  L      + R R    ++  +E ++ Q+   +
Sbjct: 7051 KILLKS---VLDQWSSHKVAF-DKINSYLMEARYSLSRFRL---LTGSLEAVQVQVDNLQ 7103

Query: 4004 NVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEER 4063
            N+  D+EK +   +       +++            + + + L ++   W N+   + E+
Sbjct: 7104 NLQDDLEKQERSLQKFGSITNQLLKECHPP----VTETLTNTLKEVNMRWNNLLEEIAEQ 7159

Query: 4064 EAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQ----EAAETIR 4119
                  +++L +++         T++  +D   +L     +  +   +     +    + 
Sbjct: 7160 LQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLL 7219

Query: 4120 EEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEA 4179
            + +  +++ L  +  LG +L           ++     L+    +L +A   +   L+  
Sbjct: 7220 KGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAG 7279

Query: 4180 MQAAVQYQDGLQAVFDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKSEAYQQQIEM 4238
            +     +   L+A+  W+  A   L    P   +DL T+++++EELK    +      ++
Sbjct: 7280 VLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDL 7339

Query: 4239 ERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQH 4298
            +RLN   EL  +    + +   +Q+    L   W  +  +   R  KL+  LL    F  
Sbjct: 7340 DRLN---ELGYRLPLNDKEIKRMQN----LNRHWSLISSQTTERFSKLQSFLLQHQTFLE 7392

Query: 4299 ALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDL 4358
              +  + +L  TE  L+ +  + G+ + +  +   H + Q ++ + Q  + ++   G  L
Sbjct: 7393 KCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRL 7450

Query: 4359 IESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4418
            +E    ++      KL +L+ +WQ V+ + +QR+  +D  +RQ + +    E L++WL +
Sbjct: 7451 LEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE 7510

Query: 4419 TERHLLASKPLGGLPETAKEQLNVHMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSA 4475
                 L    LG +P   ++   +  EV      F  ++ +Y   ++ G+Q+L      A
Sbjct: 7511 VS--YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA 7568

Query: 4476 ETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVA 4535
            E  +  ++  ++EKW+S   +L E+K KL   L    +    + D +  L   ++ L+  
Sbjct: 7569 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS-Q 7627

Query: 4536 SRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISV 4595
            S P    +    Q+   K   N V S  + + +L      L  +    D+ ++   +  +
Sbjct: 7628 SLPDHHEELHAEQM-RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELL 7686

Query: 4596 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE--ESEKSLDSELEIANDPDK 4653
            Q +WE++  +L  R + + +       F E   +L EWL   ES+ S + ++ I    +K
Sbjct: 7687 QRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEK 7746

Query: 4654 IKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTIC 4713
            +K      K++Q+ +           + G  L  K S      +++  L ++ D+W  + 
Sbjct: 7747 LK------KDYQEEIAIAQENKIQLQQMGERLA-KASHESKASEIEYKLGKVNDRWQHLL 7799

Query: 4714 GKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDI---DLVMNLIDN 4770
                 R  KL+E L+   Q    + +L  WL  +E +LA+  P+  D    + +   ++ 
Sbjct: 7800 DLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNE 7857

Query: 4771 HKAFQKELGKRTSSVQALKRSARELI---EGSRDDSSWVKVQM--QELSTRWETVCALSI 4825
             +  Q+++ K ++ V ++      L+   +    D+    +Q   + L  RW  +CA+S+
Sbjct: 7858 QQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSM 7917

Query: 4826 SKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKK 4885
             ++ ++E   R  ++F        +WL  +E+T  F    P     + T+    KE +KK
Sbjct: 7918 ERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF----PSSSGVIYTVA---KEELKK 7970

Query: 4886 LEEKRAELNKATTMGDTV-------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQ 4938
             E  + ++++  T  + +             DS  ++K  +     R++ +       Q+
Sbjct: 7971 FEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL-------QK 8023

Query: 4939 RLASALAGL---IAKQELLE----ALLAWLQWAETTLTDKDKEVIPQEIE-EVKALIAEH 4990
            R+ S L  L   I ++E  E    ++L WL   +  LT+     I    E +V+A I + 
Sbjct: 8024 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN-----IEHFSECDVQAKIKQL 8078

Query: 4991 QTFMEEMTRKQPDVDKV 5007
            + F +E++     ++++
Sbjct: 8079 KAFQQEISLNHNKIEQI 8095



 Score =  312 bits (799), Expect = 7e-84
 Identities = 772/4312 (17%), Positives = 1671/4312 (38%), Gaps = 503/4312 (11%)

Query: 1030 SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ 1089
            S S +     ++ V  Q  +  L S    E+E   +  +++   + R++ +      + Q
Sbjct: 1482 SSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK------LTQ 1535

Query: 1090 IRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 1149
            IR   E    H      T    L ++ ++ +++L  I     EF  + A    + +  +E
Sbjct: 1536 IRRYGEELREHAQCLEGTILGHLSQQ-QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1594

Query: 1150 LNVVLQN----MNQVYSMSSTYIDKLKTVNLVLKN---TQAAEALVKLYETKLCEE---- 1198
               VLQ        + S+SS       +   V+      Q A AL + YE  L       
Sbjct: 1595 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1654

Query: 1199 ---EAVIADKNNIENLISTLKQW------------------RSEVDEKRQVFHALEDEL- 1236
               E ++A    +E  +S+   W                  R +V+ + Q+  AL++E+ 
Sbjct: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714

Query: 1237 ------QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1290
                   K   + + +F    + D+     K   +QL ERW+++   I+ R+  L+ +  
Sbjct: 1715 SQASFYSKLLQLKESLFSVASKDDVKM--MKLHLEQLDERWRDLPQIINKRINFLQSVVA 1772

Query: 1291 SLKYYRDTYHPLDDWIQ----QVETTQR-KIQENQPENSKTLATQLNQQKMLVSEIEMKQ 1345
              + + +       WI+    +++TT    I ++Q          L + K   +E+E K+
Sbjct: 1773 EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ--------VALTRHKDHAAEVESKK 1824

Query: 1346 SKMDECQKYAEQYSATVKDYELQTMTYRA----MVDSQQKSPVKRRRMQSSADLIIQEFM 1401
             ++   Q +  +  +  +  +L  +  +A     +  +    V+RR++  S    + EF+
Sbjct: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH---LAEFL 1881

Query: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1461
                  + ++  + Q ++ A +S+ + E +   +E++  + ++ AK L+    ++   L 
Sbjct: 1882 QSHASLSGILRQLRQTVE-ATNSMNKNESD--LIEKDLNDALQNAKALESAAVSLDGILS 1938

Query: 1462 DAEKAGKPPFSKQKIS----SEEISTKKEQLSEALQTIQ-----LFLAKHG--------- 1503
             A+   K   S+Q+ S    ++++  + E++   L T Q     L + K           
Sbjct: 1939 KAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELL 1998

Query: 1504 ------DKMTDEER----------------NELEKQVKTLQESYNLLFSESLKQLQESQT 1541
                  ++ TD+ER                N+LE ++ + +     L  +  KQ+ +   
Sbjct: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWL-KDKAKQIAQKDV 2057

Query: 1542 SGDVKVEEKI---------VAERQQEYKEKLQGICDLLTQTEN------RLIGHQEAFMI 1586
            +   +V+ +I               E + +  G+ DL+ + +N      +++ +  + ++
Sbjct: 2058 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2117

Query: 1587 GDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ 1642
               T+    +LK   SK E  +  M    + L       ++ L E  +K+   D +L++ 
Sbjct: 2118 TRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL-KKIHSSDFSLVKT 2176

Query: 1643 KLNEAKIKCEQLNLKAEQSKKEL-------DKVVTTAIKEETEKVAAVKQLEESKTKIEN 1695
             +     K   ++ K E++   L       D V++T  + E      V Q+ E+ + ++N
Sbjct: 2177 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDN 2236

Query: 1696 -------LLDWLSNVDKDSERAGTKHKQVIEQN----------GTHFQEGDGKSAIGEED 1738
                   L ++ S V   + R    H +V +               F E D    +    
Sbjct: 2237 HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAK 2296

Query: 1739 EVNGNLLETDVDGQVGTTQ-----ENLNQQYQKVK------AQHE------------KII 1775
            E+      T  D    +TQ      ++   + KV+      AQ+E            K +
Sbjct: 2297 EITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKEL 2356

Query: 1776 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1835
               Q+ I +TQ     L    +     E E L + M  L   +E   A S+   K   SL
Sbjct: 2357 QSQQSNISSTQEN---LNSLCRKYHSAELESLGRAMTGLIKKHE---AVSQLCSKTQASL 2410

Query: 1836 QEELEK-FDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDL 1894
            QE LEK F     EF+ W   ++   +       D   L  KL   ++  + V   +  L
Sbjct: 2411 QESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2470

Query: 1895 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1954
              +T  G  +             ++ +S     +Q ++  A + F++   +C      L+
Sbjct: 2471 DAVTQEGQTLYAHLSK-------QIVSS-----IQEQITKANEEFQAFLKQCLKDKQALQ 2518

Query: 1955 DLVDKYQHYEDASCGLLAGLQACEATAS-KHLSEPIAVDPKNLQRQLEETKALQGQISSQ 2013
            D   +   +ED    L   +   E   + ++L E     P+  + ++ + +   G++ + 
Sbjct: 2519 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK-KNEVHKVEMFLGELLAA 2577

Query: 2014 QVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRS 2073
            + +++KL +  + LL   G          +    ++  +++L +   E+    Q+ L   
Sbjct: 2578 RESLDKLSQRGQ-LLSEEGH---GAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633

Query: 2074 LSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI----AGRQSSIN 2129
             ++++ L  M  W+  ++  L        ++   +D + K +   QDI       +  +N
Sbjct: 2634 EALEEALQSMWFWVKAIQDRLA----CAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLN 2689

Query: 2130 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2189
                K ++ + +++      +Q +++ L   +++         + +E + ++   +    
Sbjct: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749

Query: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL 2249
             +L+ ++E+  Q +     P   + E    +    S   E + H   LH L+ +      
Sbjct: 2750 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--- 2806

Query: 2250 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 2309
                  + EKT + S K    E+   +  + +T  +E++   + +VK    ++       
Sbjct: 2807 ------LYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLD------ 2854

Query: 2310 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2369
                      +    L   K+   +WS  + +          +  LI +    A  ++ V
Sbjct: 2855 -------AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRV 2907

Query: 2370 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA-------EL 2422
            +S    +    TA+  E       + +++ D              L++ ++       E 
Sbjct: 2908 ESLAPEVKQNTTASGCELMHTE--MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEF 2965

Query: 2423 NTKLSKLQKAQEESSAMMQ-WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2481
            + ++++L++A E+ SA+++ W Q++     K       TD E V+   +  +  +A L++
Sbjct: 2966 SGQVAQLEQALEQFSALLKTWAQQLTLLEGK------NTDEEIVECWHKGQEILDA-LQK 3018

Query: 2482 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2541
               + ++LK +L EL   + D            ++    +E N L +   +  +     L
Sbjct: 3019 AEPRTEDLKSQLNELCRFSRDL------STYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072

Query: 2542 TQ-FQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2600
             Q F+      +QWLV  ++  +    +  + + ++T  Q++Q  L E    + +   + 
Sbjct: 3073 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMML 3132

Query: 2601 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2660
            + G+ +LS        +GI + ++ A  + W +    L  +   ++   ++   ++    
Sbjct: 3133 SKGE-LLSTLLTKEKAKGI-QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAE 3190

Query: 2661 SLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI----KVAQALCED 2716
             + D LS  +  +  S        A  ++ +  Q + +EI   + Q+    + AQ L E 
Sbjct: 3191 PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEG 3250

Query: 2717 LSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL 2776
             +A     +  ++LS Q   +    K+        V  L    A  +QF    ++ Q W+
Sbjct: 3251 QAASKSFRHRVSQLSSQYLALSNLTKE-------KVSRLDRIVAEHNQFSLGIKELQDWM 3303

Query: 2777 -DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE 2835
             D      +  HP S K  VL+S     +        +    +  +  GE++L  T    
Sbjct: 3304 TDAIHMLDSYCHPTSDK-SVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEG 3362

Query: 2836 KAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEI 2895
               +Q QL ++K  W +        +++L+ +L K   Y++ V     W+D  + NL E 
Sbjct: 3363 IPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNE- 3421

Query: 2896 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA---NSLLSVCEIDKEVVTD---- 2948
                     E   A+L+    +     G  +LLN      +SLL   E+    +T+    
Sbjct: 3422 --------SERQHAELR----DKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3469

Query: 2949 --ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLG 3006
              E + L ++   + E+        E + +  +E+Q   K  +  L   +E+LD +  L 
Sbjct: 3470 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3529

Query: 3007 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3066
              A++++  T+   Q+  +   + Q  L   L     V  S      D  L  E++ Q+ 
Sbjct: 3530 GDAHTHE-TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRAL--ESLRQDW 3586

Query: 3067 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3126
                 ++ E      T+ Q   +  N +R M  +F + D+ L +        E    + E
Sbjct: 3587 QAYQHRLSE------TRTQ-FNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDE 3639

Query: 3127 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3186
              +   +  E L  S+ N+   C+    T      L+ +   ++ L ++   L       
Sbjct: 3640 VEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL------- 3692

Query: 3187 EEQVEGTIKRLEEFY-SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 3245
             E+ E ++    ++Y S  K F  +  K ++         ++T  + ++L   +V  K+ 
Sbjct: 3693 -EESESSLSSYSDWYGSTHKNFKNVATKIDK---------VDTVMMGKKLKTLEVLLKD- 3741

Query: 3246 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3305
            +E      +     G+  ++   +  + + L  ++ D   + K L   V +    L++ L
Sbjct: 3742 MEKGHSLLKSAREKGERAVKYLEEGEAER-LRKEIHDHMEQLKELTSTVRKEHMTLEKGL 3800

Query: 3306 LHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEV 3365
                 F D  ++L  W+ + +E++   + P  E    KAQ+ + K LQ+ +   + +V+ 
Sbjct: 3801 HLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKS 3860

Query: 3366 IKREGEKIATTAEPADKVKILKQLSLLDSRWEAL--LNKA----------ETRNRQLEGI 3413
            ++ +GE +    E    V +  ++  L S ++ L  + KA             N Q++G 
Sbjct: 3861 VREKGEALL---ELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917

Query: 3414 SVVAQQFHETLEPLNEWLT-----TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3468
            +++ Q        L + +      T +     C         LE ++ +H + +D +   
Sbjct: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 3977

Query: 3469 NKHLHQA-----------VSIGQSLKVLS--------SREDKDMVQSKLDFSQVWYIEIQ 3509
               L              +S  +++K +         +R   D++ S  D S        
Sbjct: 3978 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4037

Query: 3510 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR- 3568
            +      + ++Q L  A+   +   E+ +  +E+   L      D   + + ++ SEL  
Sbjct: 4038 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRRHSELEL 4094

Query: 3569 ------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3621
                  V Q    ++K    QA +N + E + + T  E      ++  +  ++ D+ + S
Sbjct: 4095 NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQS 4154

Query: 3622 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3681
             ++    E+ LQ  R  H      C  + +V +E  + E   L   +A    +  + LKK
Sbjct: 4155 NNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4209

Query: 3682 EA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3738
             A   +  K  ++ L +    ++E +    +E +++  +   +R+  + D I +K++ + 
Sbjct: 4210 LALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQ-VS 4268

Query: 3739 AAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKD 3797
               L      Q+   EL  W  E +  +          D     L        E+   + 
Sbjct: 4269 VTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4328

Query: 3798 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3857
            ++  L+K   ++M      E+Q ++K L     + + +  +  +R   L +A S   QF 
Sbjct: 4329 LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFL 4388

Query: 3858 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3917
                +    + + +  I       L  + + +Q +  +  +  +  ++  +  +   G +
Sbjct: 4389 MAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRE 4448

Query: 3918 LL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 3976
            L+ E++  E   +  K     ++Y  + +    R   L++ +     F +  D+    L+
Sbjct: 4449 LMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLK 4508

Query: 3977 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4036
            +         ++  E  ++  Q+++ +N+     + + L  TL++ G+ ++      D  
Sbjct: 4509 QADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHS 4568

Query: 4037 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIKDTQ-DF 4094
                 + +KL+ +   +  I  L +++  K+ + + LA K +   + L   ++ + +  F
Sbjct: 4569 Y----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLSELEAQF 4623

Query: 4095 IRDLEDPGIDPSVVK--QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4152
            +R  + P  D +V +    Q+    I +E+ GL E +D  +N   E   + G+P +P   
Sbjct: 4624 LRMSKVP-TDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPWQP--- 4678

Query: 4153 KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT 4212
              +  L + +  L +  + R+  LE+   A  +++   Q +   +     + + ++    
Sbjct: 4679 DKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE--- 4735

Query: 4213 DLETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTVQDPLM 4266
              ET+  + E+LK + S A   Q   I ++R+    E L   L  +  E  +H +Q    
Sbjct: 4736 --ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQG 4792

Query: 4267 ELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKA 4326
            ELKL+  ++ E +   + ++  ++     FQ  +   L WL   +  LS    +  + + 
Sbjct: 4793 ELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQD 4848

Query: 4327 IEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLE 4386
            I+ E+ K  + Q +V +    + A++    +    +    +++L++ L  L++   ++ E
Sbjct: 4849 IQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE 4908

Query: 4387 KTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQLNVHME 4445
                R+  L     Q + ++   +    WL D +  L LA   L    E+A+E L  HME
Sbjct: 4909 ALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKSHME 4966

Query: 4446 VCAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETKLNERK 4501
                F + E+ + S +++   ++A        + + +++Q + +L+ + + +      + 
Sbjct: 4967 ----FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQV 5022

Query: 4502 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEHKVFAN 4557
              L+       ++  + ++ I  +   E+ L   S  SL+  +   +    + EHK   +
Sbjct: 5023 DLLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEHKALVS 5079

Query: 4558 EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4617
             VNS  E+I+ L++  + L+          +   + +V  RW ++     ++ + L+DA 
Sbjct: 5080 VVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAV 5139

Query: 4618 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4677
                 F+    K  E +++ +  L           ++ T L  H  F   L  + S    
Sbjct: 5140 DEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGM 5199

Query: 4678 TNRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728
              +   S+          E+  L  +   + D    +++K  T  GK V+++ K  E + 
Sbjct: 5200 LRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKDREMV- 5257

Query: 4729 FSGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK---------AF 4774
                    + ++  W+     Y   P +  D  +  ++ +++    NH+           
Sbjct: 5258 -----ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKMAEEQK 5311

Query: 4775 QKELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSI 4825
            +K LG  T      S+Q    AL    R+ I+    +    K   QELS + + +     
Sbjct: 5312 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLT 5371

Query: 4826 SKQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALR 4873
            +  T+L+A                EE       L+E  A  ++ L  +G L       + 
Sbjct: 5372 TILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIG 5431

Query: 4874 TLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWA 4933
             L + H++ +++ E + ++LN+A +  +      + + +  I  WI   +      +AW 
Sbjct: 5432 KLTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHGTIAWN 5486

Query: 4934 KQHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---EIEEVK 4984
               Q R    L   + ++       LEA+   LQ+  +   T+K  + + +   E EE++
Sbjct: 5487 SASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELR 5546

Query: 4985 ALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5036
             +I   +  ++ +     D+ K     K+  A     Q+ +   + GR   K
Sbjct: 5547 QMI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595



 Score =  305 bits (782), Expect = 6e-82
 Identities = 721/4187 (17%), Positives = 1586/4187 (37%), Gaps = 657/4187 (15%)

Query: 1310 ETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAE------------- 1356
            E +     + Q +    L++       L+SE+E   S   +C +Y E             
Sbjct: 1200 EVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGS 1259

Query: 1357 ----QYSATVKDYELQTMTYRAMVDSQQKS---PVKRRRMQSS-----------ADLIIQ 1398
                + +  + D E      + ++  QQK+     K+R +Q              D   +
Sbjct: 1260 KEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHE 1319

Query: 1399 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
            E   L +    L     +  +    +L++ E  E + E   +   +     ++++S  S 
Sbjct: 1320 ELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSL 1379

Query: 1459 TLKDAEKAGKPPFSKQ----KISSEEISTKKEQLSEALQTIQLF--LAKHGDKMTDEERN 1512
                +E      FSK+     + +E +  +  ++    Q  QL    AK   +   +  +
Sbjct: 1380 ESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED 1439

Query: 1513 ELEKQVKTLQ-------------ESYNLLFSESLKQLQESQTSG---DVKVEEKIVAERQ 1556
             LE+ +KT++             E+ ++  +E  K+L   +TS    D+++ +  +    
Sbjct: 1440 TLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ--IKVTI 1497

Query: 1557 QEYKEKLQGICDLLTQTEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA- 1613
            QE + KL  I  L  + ++  + +   E+  I     ++++Y  +  E  + ++G+    
Sbjct: 1498 QEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGH 1557

Query: 1614 LAEVVKNTENFLKENGEKLSQEDKALIEQKLNEA---KIKCEQLNLKAEQSKKELDKVVT 1670
            L++  K  EN  K        EDK  +  K+  +     K  Q ++   Q+ + L   +T
Sbjct: 1558 LSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAIT 1617

Query: 1671 -------------------TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG 1711
                                A++++ E +  +++ +E +T +ENLL     ++K+     
Sbjct: 1618 AFSASARKVVNRDSCVQEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE----- 1670

Query: 1712 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1771
                  +    T  + G+ K++  E D              +   +  +  + Q ++A  
Sbjct: 1671 ------LSSFLTWLERGEAKASSPEMD--------------ISADRVKVEGELQLIQALQ 1710

Query: 1772 EKIISQHQAVIIATQSAQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKM 1829
             +++SQ      A+  +++L  K+  +   S ++ + ++ ++++L   +        K++
Sbjct: 1711 NEVVSQ------ASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRI 1764

Query: 1830 KLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVIS 1889
                S+  E ++FD     F  W++    EL+        I      L R K  + +V S
Sbjct: 1765 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVES 1822

Query: 1890 HKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVL 1949
             KG+L+  ++ G+               K+ +     ++      A D F+       V+
Sbjct: 1823 KKGELQ--SLQGHL-------------AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVV 1867

Query: 1950 GNN---LKDLVDKYQHYEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKA 2005
                  L  L +  Q +   S G+L  L Q  EAT S + +E   ++ K+L   L+  KA
Sbjct: 1868 ERRQLALSHLAEFLQSHASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKA 1925

Query: 2006 LQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK 2065
            L+    S  V+++ +   A+  L    S    +   + T D + G  E +   +  +  +
Sbjct: 1926 LE----SAAVSLDGILSKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSE 1979

Query: 2066 LQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQ 2125
                     + QD  +E+L  + ++E    ++        ALQ  +     LE ++   +
Sbjct: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2039

Query: 2126 SSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELF 2185
              +  + +K K+  +  D + A  +  ++  L   + +      E   +   L   +  +
Sbjct: 2040 HELCWLKDKAKQIAQ-KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREY 2098

Query: 2186 ENLSEKLQTFLETKTQAL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHK 2231
            +NL   +   LE  +  + T   +  KD  +L               Y Q+    F    
Sbjct: 2099 QNLKSAVSKVLENASSVIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKG 2156

Query: 2232 KHLEVLHSLLKEISSHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQ 2285
            KH   L S LK+I S     + +D    ++K  ++S+K +E  D ++      + V S +
Sbjct: 2157 KH---LLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTR 2213

Query: 2286 EQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEI-QK 2344
            ++++ +        + + +  + +  +     AE+L K  E   K +   +L+  E+  K
Sbjct: 2214 DEIEGWS------NNCVPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSK 2264

Query: 2345 VNNSGISLCNLISAVTTP----------------AKAIAAVKSGGAVLNGEGTATNTEEF 2388
            VN+    L  L   + TP                AK I  V + G + +    +T  E+F
Sbjct: 2265 VND----LKELTKNLETPPDLQFIEADLMQKLEHAKEITEV-AKGTLKDFTAQSTQVEKF 2319

Query: 2389 W--ANKGLTSIKKDMTDISHGYEDLGL-LLKDKIAELNTKLSKLQKAQEESSAMMQ---- 2441
                    T +++ + + +       L  +KD   EL ++ S +   QE  +++ +    
Sbjct: 2320 INDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS 2379

Query: 2442 -WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE------------ 2488
              L+ + +  T   +          KTQ    +S E    +++ + QE            
Sbjct: 2380 AELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKES 2439

Query: 2489 ---------LKDKLTEL----------------LEENPDTPEAPRWKQM-------LTEI 2516
                     L+ KL +L                + +   T  A   KQ+       +T+ 
Sbjct: 2440 SDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKA 2499

Query: 2517 DSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSVLGPLSIDPNM 2574
            + ++Q   +  +  +Q L++ ++ L  F+    +L  W+  +E+      LG        
Sbjct: 2500 NEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPE 2559

Query: 2575 LNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSL 2634
               +  +V++ L E    +   ++L+  GQ +LS  G      G +  QL    Q    +
Sbjct: 2560 KKNEVHKVEMFLGELLAARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRM 2618

Query: 2635 TGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQ 2694
            T +    C     A+ +    +  L+S+   +  + ++L+ + +     D + ++L   Q
Sbjct: 2619 TKEKLRSC---QVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQ 2675

Query: 2695 KMKQEIQQEKKQIKVAQALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQ 2753
             +   + + + ++K+  A+ +   AL    +  +  +  QLE + + + D+   + +   
Sbjct: 2676 DIL--LMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQS 2733

Query: 2754 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHK 2804
             L+S  +  + + +     + W+++   +Q   HP+  +         LD L+S++ + +
Sbjct: 2734 TLESVISQWNDYVERKNQLEQWMES--VDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAE 2791

Query: 2805 DFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKL 2864
            D ++ L        + IA+   L  KT+  +++        +KT ++      KE+  K+
Sbjct: 2792 DHTRAL-------HRLIAKSRELYEKTE--DESFKDTAQEELKTQFNDIMTVAKEKMRKV 2842

Query: 2865 KESLEKALKYKEQVETLWPWIDKC-----------------QNNLEEIKFCLDPAE-GEN 2906
            +E ++  L Y + V     W+                    Q  L +IK  +D  E G +
Sbjct: 2843 EEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGAS 2902

Query: 2907 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 2966
             +++++SL  E+ Q            N+  S CE+    +  E ++L        + +  
Sbjct: 2903 RLSRVESLAPEVKQ------------NTTASGCEL----MHTEMQALRADWKQWEDSVFQ 2946

Query: 2967 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQ----- 3021
             + CLEN+  +    ++       QL+ A EQ        +Q      LT+L+ +     
Sbjct: 2947 TQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQ-----QLTLLEGKNTDEE 3001

Query: 3022 --------QKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQV 3073
                    Q+ L AL+      + L   L      S+  S    +V  + +E++ L  Q 
Sbjct: 3002 IVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQA 3061

Query: 3074 DEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLK 3133
             + C   E  LQ         +     F +F   L +          + +    +   L+
Sbjct: 3062 SKGCQNKEQILQ---------QRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQ 3112

Query: 3134 KLEALMASNDNANKTCKMMLATEE------TSPDLVGIKRDLEALSKQCNKLLDRAQARE 3187
            K++  ++ ++N      MML+  E      T     GI+  + A  +           +E
Sbjct: 3113 KIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKE 3172

Query: 3188 EQVEGTIKRLEEFYSKLKEFSILLQKAEE--HEESQGPVGMETETINQQLNMFKVFQKEE 3245
              +E    ++++F    +     L K E+  HE S     +  +   QQ        +  
Sbjct: 3173 SALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQK------LQSV 3226

Query: 3246 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3305
            +E +   +  +N L +   Q      +++   H +  +++++  L+    ++ ++L   +
Sbjct: 3227 LEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIV 3286

Query: 3306 LHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEV 3365
                +F   ++ L  WM D   ++ +   P+++  V+ ++  + + L  +  +++  +++
Sbjct: 3287 AEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKM 3346

Query: 3366 IKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3425
            I   GE +     P     I +QL  +   W +LL+       QLEG       + + + 
Sbjct: 3347 IVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVR 3406

Query: 3426 PLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVL 3485
              + W+ ++E  L   E    +       + + K L +++++++  L      G  +   
Sbjct: 3407 QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGM--- 3463

Query: 3486 SSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHD 3545
                +  + Q +L   Q  Y  IQE++       ++ +   + +  D      WL +  +
Sbjct: 3464 ---TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQE 3520

Query: 3546 KLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQ 3604
            KL + SV +         ++ LR LQE  L       QALLN  L   +      +   +
Sbjct: 3521 KLDQYSVLEGDAH---THETTLRDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3575

Query: 3605 DK-LEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQV 3663
            D+ LE+++  ++      ++        +   R +    +++  WL   E E   +E   
Sbjct: 3576 DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAE-EKKWHEEVT 3634

Query: 3664 LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERY 3723
               +E  +   R +E+  E+  N  +     +++S                       RY
Sbjct: 3635 AYRDEVEEVGARAQEILDESHVNSRMGCQATQLTS-----------------------RY 3671

Query: 3724 RLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQ 3783
            + +   + ++++ ++  I   ++ + +  +   W   T K   +  ++  + D+    + 
Sbjct: 3672 QALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHK---NFKNVATKIDKVDTVMM 3728

Query: 3784 VQKTFTMEIL-----RHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQI 3838
             +K  T+E+L     +   ++    + G + +    E E + ++K++   ++    +   
Sbjct: 3729 GKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTST 3788

Query: 3839 NSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLR 3898
              + ++ LE+   L  +F +  + L  W+ E Q I+     P +E    + Q  +++ L+
Sbjct: 3789 VRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQ 3848

Query: 3899 ELIAEHKPHIDKMNKTGPQLLEL---------------------SPGE-------GF--- 3927
            + +  H+P +  + + G  LLEL                     S G+       GF   
Sbjct: 3849 QTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDR 3908

Query: 3928 --SIQEK-----YVAADTLYSQIKEDV------------------KKRAVALDEAISQST 3962
              ++Q K        AD L +++K++V                  ++   +L+  + +  
Sbjct: 3909 LNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHV 3968

Query: 3963 QFHDKIDQI---LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETL 4019
               D + Q    L +++  +E   QPP   AE       I + K+     E+ +   + L
Sbjct: 3969 SRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEA------IKQVKHFRALQEQARTYLDLL 4022

Query: 4020 KQRGEEMIARSGGTDKDI--SAKAVQDKLDQMVFI---WENIHTLVEEREAKLLDVMELA 4074
                +   A    T KDI  + + ++ KL Q   +   WE I  L  E    L D  +  
Sbjct: 4023 CSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQL 4082

Query: 4075 EKFWCDHMSLIVTI-----KDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEEL 4129
            +     H  L + I        +DF++ L+           +Q +  TI E+++ L ++ 
Sbjct: 4083 QNMKRRHSELELNIAQNMVSQVKDFVKKLQ----------SKQASVNTIIEKVNKLTKK- 4131

Query: 4130 DIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG 4189
                             ++    K I+ LN  W  L +   +   + EE +Q    Y D 
Sbjct: 4132 -----------------EESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDC 4174

Query: 4190 LQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLL 4249
            +  V  +++    +  +++   +D E+    +E LK+      +++  +E L  Q + ++
Sbjct: 4175 MNVVEVFLEKFTTEWDNLA--RSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMI 4232

Query: 4250 KKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTH 4309
            + +  + DK  V++    L+  W  LE+ I  +       L  L   Q    EL+ W   
Sbjct: 4233 EHLNLD-DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEE 4291

Query: 4310 TEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASN 4369
             +  ++E       P   +  L  H  + +++ A Q  ++++ K  + ++      E   
Sbjct: 4292 QQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQV 4351

Query: 4370 LQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPL 4429
            +Q  L         + +   QR++ L+ AL +   F   +      +   ER ++  + +
Sbjct: 4352 IQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHI 4411

Query: 4430 GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEK 4489
              LP+   +Q+       A+ +  +     L  +G++++    +  ++ +   +  L+  
Sbjct: 4412 CLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSV 4471

Query: 4490 WESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLIL----DTV 4545
            ++SV  K + R  +LE+ L     F        +WL QA+    + + P + L      +
Sbjct: 4472 YDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD----IVTFPEINLMNESSEL 4527

Query: 4546 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4605
              Q+ +++    +   +   ++ L +TG  +     + D   +   L ++  ++  +V  
Sbjct: 4528 HTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVAL 4587

Query: 4606 LVERGRSLDD---ARKRAKQFHEAWSKLMEWLE---------ESEKSLDSELEIANDPDK 4653
              ++   + +   ARK      E  ++ +  LE          ++ +++  L + +    
Sbjct: 4588 AKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRA 4647

Query: 4654 IKTQLAQHKEFQKSLGAKHSVYDTT----------------NRTGRSLKEKTSLADDNL- 4696
            I  ++A   E    L  K   + +T                +R  R  +++ SL +D   
Sbjct: 4648 ILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTS 4707

Query: 4697 ----------KLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDA---LQALIDW 4743
                      +L+  L  ++++   +  +++  + KL+     +G   D+   L+ +   
Sbjct: 4708 AYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4767

Query: 4744 LYRVEPQL---------AEDQPVHGDIDLVMNLIDNHKA-----------FQKELGKRTS 4783
            L  + P L          + Q   G++ L+ + I                FQ E+ +   
Sbjct: 4768 LEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR--- 4824

Query: 4784 SVQALKRSAREL---------IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTR---- 4830
            S+  L+R   EL         ++  +++   +++  +E+ +    + ALS  ++ +    
Sbjct: 4825 SLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA 4884

Query: 4831 -------LEAALRQAEE-------------------------FHSVVHALLEWLAEAEQT 4858
                   LE +L +  E                         ++ V  A  +WL +A++ 
Sbjct: 4885 KELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQEL 4944

Query: 4859 LRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHW 4918
            L+  G   D E A   L   H EF    ++  + L +  ++  T+  +  P         
Sbjct: 4945 LQLAGNGLDVESAEENL-KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTG------- 4996

Query: 4919 ITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQ 4978
                +   E+ +A  +   QR++       A+ +LL+   A  QW +     K +E + +
Sbjct: 4997 ----KEDLEQKVASLELRSQRMSRDSG---AQVDLLQRCTA--QWHD---YQKAREEVIE 5044

Query: 4979 EIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRF 5038
             + + +  ++E   F    T    + ++    +K   +  +S    I  L++        
Sbjct: 5045 LMNDTEKKLSE---FSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEE-------- 5093

Query: 5039 PASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALD 5085
             AS L  +G+     T +  +  +  +W ++  +A ++ + L DA+D
Sbjct: 5094 KASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5140



 Score =  295 bits (754), Expect = 1e-78
 Identities = 742/3922 (18%), Positives = 1500/3922 (38%), Gaps = 500/3922 (12%)

Query: 1108 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1167
            E+EK  K  E +  DL           S A  S     ++  L      + ++YS    Y
Sbjct: 4877 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4927

Query: 1168 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1227
                +  N  L++   A+ L++L    L  E A        ENL S ++ + +E      
Sbjct: 4928 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 4972

Query: 1228 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1287
             FH+  +EL    A  D + K   + DL+     +K   L  R Q +      ++  L+ 
Sbjct: 4973 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5026

Query: 1288 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1344
              +    + D     ++ I+ +  T++K+ E    +  +S     +L++ K LVS +   
Sbjct: 5027 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5084

Query: 1345 QSKMDECQKYAEQYSATVKDYELQTMT------------YRAMVDSQQKS---------- 1382
              K+   ++ A Q   T  D    T++             RA+   Q+K           
Sbjct: 5085 HEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTG 5144

Query: 1383 -------------------PVKRRRMQSSADLI-IQEFMD-----LRTRYTALVTLMTQY 1417
                               P       S A+L+ + E+ D     L  + +AL  L  Q 
Sbjct: 5145 FNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQT 5204

Query: 1418 IKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSN----ISKTLKDAEKAGKPPFSK 1473
            +    D       EE  L +E     ++   +Q+ V      + + LKD E       S 
Sbjct: 5205 LSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264

Query: 1474 Q---KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1530
            +   + + E +     ++   L+ +Q+ L +         R  +EK  +  +E Y  L++
Sbjct: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTE-----ATNHRQNIEKMAEEQKEKYLGLYT 5319

Query: 1531 --ESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGD 1588
               S   LQ ++ + D+K+ ++I    Q + KE  Q      ++  ++ +  Q   +  D
Sbjct: 5320 ILPSELSLQLAEVALDLKIRDQI----QDKIKEVEQ------SKATSQELSRQIQKLAKD 5369

Query: 1589 GTVELKKYQSK----------QEELQKDMQGSAQALAEVVKNTENFLKENGE-------- 1630
             T  L K ++K          Q+ L +++ G    L E+    + FL++NG+        
Sbjct: 5370 LTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKK 5429

Query: 1631 --KLSQEDKALIEQ------KLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA 1682
              KL++  +  I Q      KLN+A    E+ N   E   K ++K    A    T    +
Sbjct: 5430 IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA--HGTIAWNS 5487

Query: 1683 VKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNG 1742
              QL E     + LL+    +D + E A T+  Q +       +     + +G E E   
Sbjct: 5488 ASQLREQYILHQTLLEESKEIDSELE-AMTEKLQYLTSVYCTEKMSQQVAELGRETEELR 5546

Query: 1743 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKI---ISQHQAVIIATQSAQVLLEKQGQYL 1799
             +++  +        ++  +  +K +A+ +K+   + Q QA + + +  ++ L++Q  + 
Sbjct: 5547 QMIKIRLQNL-----QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHR 5601

Query: 1800 SP--EEKEKLQKNMKELKVHYET----------------ALAESEKKMKLTHSLQEELEK 1841
                 E E L+  ++ +++                    AL   E+  +L H+  ++   
Sbjct: 5602 QHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI 5661

Query: 1842 FDADYTEFEHWLQQ----------SEQELENLEAGADDINGLMTKLKRQ-------KSFS 1884
              A   ++E + Q+          + +E+E+      +I  L  ++ R        K + 
Sbjct: 5662 MQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQ 5721

Query: 1885 EDVISHKGDLRYITISGNR---------VLEAAKSCSKRDGGKVDTSATHREVQRKLDHA 1935
            E + S     + +T+             V   A+     DG  + T + H  V       
Sbjct: 5722 EQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSV------- 5774

Query: 1936 TDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKN 1995
                     +C+ L + + +     +  E+ +   ++   AC + +      P+A    +
Sbjct: 5775 ---VMMTAGRCHTLLSPVTE-----ESGEEGTNSEISSPPACRSPS------PVANTDAS 5820

Query: 1996 LQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL 2055
            + + +   +AL  +      A      +A       G L P+       L D+   +E L
Sbjct: 5821 VNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPG-LEPSAT---AKLGDLQRSWETL 5876

Query: 2056 SKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQ---GQVPLNSTAL-QDII 2111
               ++E+   L   L R    QD L  +   M  +E  L E    G+ P +  A  Q ++
Sbjct: 5877 KNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALM 5936

Query: 2112 SKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2171
             + +ML+ +I   QSS+    E V +  E  DP+   +LQ+ +  L+ R S    K    
Sbjct: 5937 DEILMLQDEINELQSSL--AEELVSESCEA-DPAEQLALQSTLTVLAERMSTIRMKASGK 5993

Query: 2172 LAKMEELKTKVELFENLSEK-----------LQTFLETKTQALTEVDVPGKDVTELSQYM 2220
               +EE K   +L E   E+           L ++L +    L     P K+  ++   +
Sbjct: 5994 RQLLEE-KLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQL 6052

Query: 2221 QESTSEFLEHKKHLEVLHSLLKEISSHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEK 2277
             +  +  +E ++ +  L     E+S H    L   KA   ++   L+ K + ++ ++ E 
Sbjct: 6053 MDCQNMLVEIEQKVVAL----SELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108

Query: 2278 KEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFG------AEDLGKSLEDTKKL 2331
            + A+    +QL+      +  +S +  T  + P VQ           +    SL+  K+L
Sbjct: 6109 QRALHD--KQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKEL 6166

Query: 2332 QEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWAN 2391
            +++ + +   ++ V + G  +    SA  T   A          L  EG  ++ E+    
Sbjct: 6167 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRM 6226

Query: 2392 KGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA--QEESSAMMQWLQKMNKT 2449
            K               +E L         E +TK   LQ    QE+   +     ++   
Sbjct: 6227 K---------------WESLH-------QEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSG 6264

Query: 2450 ATKWQQTPAPTDTEAVKTQVEQ-NKSFE-------AELKQNVNKVQELKDKLTELLEENP 2501
               ++      D  AV + ++  N++FE          +Q+++  Q+L D ++       
Sbjct: 6265 VPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLD 6324

Query: 2502 DTPEAPRWKQMLTEIDSKWQELNQ--LTIDRQQKLEESSNNLTQF-QTVEAQLKQWLVEK 2558
            D  E       L   +++    NQ  L  D ++  EE   N   F Q          V +
Sbjct: 6325 DVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIE 6384

Query: 2559 ELMVSVLGPLSIDPNMLNTQRQQVQ-------------------------ILLQEFAT-- 2591
            + +  +LG LS+  +++N +  Q++                         I+LQ+ A   
Sbjct: 6385 DTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVF 6444

Query: 2592 RKPQYEQLTAAGQ----------GI--LSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2639
             +P  EQ+ A  Q          GI  L R G+   +     ++L+ +   +D L   + 
Sbjct: 6445 EQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIG 6504

Query: 2640 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2699
             R   ++Q +   +QY+  L+ L+D L     K++    +        QQL    K K+ 
Sbjct: 6505 SRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQL--LDKHKEY 6562

Query: 2700 IQQEKKQIKVAQALCEDLS--ALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQS 2757
             Q  +  + + + L   +   A+ KE     EL  Q   +LK       +A      L+ 
Sbjct: 6563 FQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLK-------RAHKRGVELEY 6615

Query: 2758 ACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMY 2817
               +     +  ++    L+  +        +    D L   I  ++    +L       
Sbjct: 6616 ILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKL 6675

Query: 2818 EKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQ 2877
             + + +G+ LL+    S+   L+ QLN +   W +   ++ +  ++L+  L+   +Y+ +
Sbjct: 6676 YQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSE 6732

Query: 2878 VETLWPWIDKCQNNLE--EIKFCLDPAEGE---NSIAKLKSLQKEMDQHFGMVELLNNTA 2932
               L  W+   ++ LE    +    P E E   + +       KE+D    +   + +T 
Sbjct: 6733 SADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTG 6792

Query: 2933 NSLLSVCEIDKEVVTDENK-------SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 2985
            N LL + ++D   +  E          L+  +  V E+LH  +  ++ +  +    + +S
Sbjct: 6793 NQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQ--MDKLPSRHAISEVMS 6850

Query: 2986 KESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVE 3045
              S  +    K++ +I +S+G +A  ++YL   +  +  +   +  VD   +    +  +
Sbjct: 6851 WISLMENVIQKDEDNIKNSIGYKAI-HEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQ 6909

Query: 3046 ASDSKGT--SDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAE 3103
              +SK +  +D   Q+  + +    L   V EK   LE  L+    ++N ++ + + F  
Sbjct: 6910 DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFET 6969

Query: 3104 FDDELDSMAPVGRDAET------LQKQKETIKAFLKKLEAL------MASNDNANKTCKM 3151
             +  L     +G  A         Q  ++ IKA  K++E +      +  N   + +  +
Sbjct: 6970 QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIV 7029

Query: 3152 MLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILL 3211
            M    E       +   +  L      +LD+  + +   +     L E    L  F +L 
Sbjct: 7030 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLT 7089

Query: 3212 QKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST 3271
               E               +  Q++  +  Q +++E  +   Q    +   L++      
Sbjct: 7090 GSLE--------------AVQVQVDNLQNLQ-DDLEKQERSLQKFGSITNQLLKECHPPV 7134

Query: 3272 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD----TEE 3327
             T+ L + L +VN RW  L +++A++    +  L    R++D  +   S +      T E
Sbjct: 7135 -TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNE 7193

Query: 3328 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTV-------EVIKREGEKIATTAEPA 3380
            L+            V   IQ+   L + L   K ++       E +K++ +  A +A  +
Sbjct: 7194 LLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQS 7253

Query: 3381 DKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVN 3440
            D++ + + L  L    E  L K +T    L+   +  + F ++LE L  W+   E+ L  
Sbjct: 7254 DQLSLSQHLCAL----EQALCKQQT---SLQAGVLDYETFAKSLEALEAWIVEAEEILQG 7306

Query: 3441 CEPI-GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLD 3499
             +P   +  S ++E++ + K       +    L +   +G  L  L+ +E K M     +
Sbjct: 7307 QDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LNDKEIKRMQ----N 7361

Query: 3500 FSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
             ++ W + I  ++  R   LQ  L   + F E     M +L +   KL+     +Y  + 
Sbjct: 7362 LNRHWSL-ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY--QH 7418

Query: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619
            L +QQ    + Q ++  R+Q +   +++G  LL+Q   D+      KL  +  +++ + +
Sbjct: 7419 LLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIR 7478

Query: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679
             +      ++  ++  +R     E+L  WL  VEV  L             QA+    E+
Sbjct: 7479 RAQQRRGIIDSQIRQWQRYREMAEKLRKWL--VEVSYLPMSGLGSVPIPLQQARTLFDEV 7536

Query: 3680 KKEAK---NNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEE 3736
            + + K     +       E    LL      A   L+  +AE  E+++  S  + ++ ++
Sbjct: 7537 QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKK 7596

Query: 3737 IDAAILRSQQFDQAADAELSWITETEKKL-MSLGDIRLEQDQTSAQLQVQKTFTMEILRH 3795
            +   +   ++ ++     L  +   +KKL  SL D     ++  A+    K     +   
Sbjct: 7597 LAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD---HHEELHAEQMRCKELENAVGSW 7653

Query: 3796 KDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3855
             D +  L      +    S ++   + ++++ + + ++ +C   S R  Q+    +    
Sbjct: 7654 TDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 7713

Query: 3856 FWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTG 3915
            F E  +EL  WLT+ +S +SQ     +E E + + ++++++   +  E+K  + +M   G
Sbjct: 7714 FSEKNKELCEWLTQMESKVSQNGDILIE-EMIEKLKKDYQEEIAIAQENKIQLQQM---G 7769

Query: 3916 PQLLELS-PGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974
             +L + S   +   I+ K    +  +  + + +  R   L E +    Q    +  +   
Sbjct: 7770 ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7829

Query: 3975 LERIVERLRQPPSI-SAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGT 4033
            L  I   L +P    S   E+I+ +++E + +  D+EK      ++    E ++      
Sbjct: 7830 LAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDAC 7889

Query: 4034 DKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQD 4093
              D    ++Q     +   W NI  +  ER  K+ +   L +KF  D+      +K ++ 
Sbjct: 7890 ATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER 7949

Query: 4094 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4153
                    G+  +V K++ +  E  + ++     +L+++      L           +K+
Sbjct: 7950 TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQ 8009

Query: 4154 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD 4213
             + E N  WD+L K     + +L+  +    +++    ++  W+     +L ++      
Sbjct: 8010 MVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC 8069

Query: 4214 LETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWD 4273
               V+ +I++LK F+ E      ++E++  Q E L++K +E  D   +++ L EL+    
Sbjct: 8070 --DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK-SEPLDAAIIEEELDELRRYCQ 8126

Query: 4274 SL-------------------EERIINRQHKLE--GALLALGQFQHALDELLAWLTHTEG 4312
             +                   E  + +R+ +LE   AL  L     + D LL+    +  
Sbjct: 8127 EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 8186

Query: 4313 LLSEQKPV-----GGDPKA----IEIELAKHHVLQNDVLAHQS-TVEAVNKAGND----L 4358
             LS  +P+     G D  A    I +E    + L  D+ +  S  + + ++ G D     
Sbjct: 8187 SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 8246

Query: 4359 IESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTD 4418
            +  + G     +    E   +  +N ++ T      L+  +RQ       ++D +  +  
Sbjct: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQ---LGKALDDSRFQIQQ 8303

Query: 4419 TERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETN 4478
            TE  + +  P G   +T+ +    +M++     +  ++ K L  K ++     P     +
Sbjct: 8304 TENIIRSKTPTGPELDTSYKG---YMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLH 8360

Query: 4479 -IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASR 4537
              +     + ++WE ++ +   ++ ++++ L    +F++ L     WL   E+ L    R
Sbjct: 8361 STETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQR 8420

Query: 4538 PSLILD--TVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISV 4595
              L  D  T+  QI + K     V+  +  I+ ++           K+   L ++ L  +
Sbjct: 8421 LELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQM 8479

Query: 4596 QSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS--------------- 4640
              RW++V   L E    L DA  + + FHE    L+  LE  ++                
Sbjct: 8480 NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 8539

Query: 4641 ---------------LDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685
                           L+S+L +A+  D +  QL  + E    L AK  V+   NR    L
Sbjct: 8540 LQDHHKQLMQIKHELLESQLRVASLQD-MSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLL 8598

Query: 4686 KEKTSLADDNLKLDDMLSELRD 4707
            KE +    +  KL D+ S  +D
Sbjct: 8599 KEVSRHIKELEKLLDVSSSQQD 8620



 Score =  294 bits (752), Expect = 2e-78
 Identities = 839/4655 (18%), Positives = 1777/4655 (38%), Gaps = 599/4655 (12%)

Query: 572  EPNSLQTLKLMQIRKPLLKSSLLDQNL---TEEEINMKFVQDLLNWVDEMQVQL---DRT 625
            +PN  + LK  Q   P +  +LL  +L   +E E     ++ L+   D +   L   +R 
Sbjct: 4293 QPNIAEALK--QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQ 4350

Query: 626  EWGSDLPSVESHL--------ENHKNVHRAIEEFESSLKEA--KISEIQMTAPLKLTYAE 675
                 L   +SH+        +  K +++A+ E    L       S+IQ     K+ + E
Sbjct: 4351 VIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHER-KIMFRE 4409

Query: 676  KLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIA 735
             +  L    +K + T ++ +  L T  N                  EV   W++      
Sbjct: 4410 HICLLPDDVSKQVKTCKSAQASLKTYQN------------------EVTGLWAQGR---- 4447

Query: 736  RKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 795
                   ELM+E+ ++E++     E+  +L                 +Q+ +  +LQ C 
Sbjct: 4448 -------ELMKEVTEQEKS-----EVLGKL---------------QELQSVYDSVLQKCS 4480

Query: 796  CVEQHIKENTAYFEFFN-DAKEATDYLRNLKDAIQRKYSC-DRSSSIH----KLEDLVQE 849
               Q +++N    + F  D  +A  +L+        + +  + SS +H    K ++++++
Sbjct: 4481 HRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ 4540

Query: 850  SMEEKEELLQYKSTIANLMGKAKTIIQ--LKPRNSDCPLKTSIPIKAICDYRQIEITIYK 907
            S E +  LL  + T   ++     +    L  + +  P + ++ +    D        YK
Sbjct: 4541 SPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKD------KFYK 4594

Query: 908  DDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWH 967
              E +LA   + +  ++ + + +E     +  +  P      DLA       +  L+L  
Sbjct: 4595 VQEAILARKEYASLIELTTQSLSELEAQFLRMSKVP-----TDLA------VEEALSLQD 4643

Query: 968  ESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQ 1027
                 +  V      ++E+++ +    ++ +   P +   +++ L  R    L+   E +
Sbjct: 4644 GCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVT-LYHR----LKRQTEQR 4698

Query: 1028 VFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE-NCEDRL 1086
            V    D T   +E     Q  +  LKS + E+ + +   L   E   +   L  + +D  
Sbjct: 4699 VSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSG 4758

Query: 1087 IRQIRTPLERDDLHESVFRITEQ------EKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140
            I   R  +  +DL   +  +  +      +  + EL+ L   +G    +CE    Q+   
Sbjct: 4759 IVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSI-- 4816

Query: 1141 SSVPTLRSELNVVLQNMNQVYSMSS--TYID--------KLKTVNLVLKNTQAAEALVKL 1190
                  ++E++  L  + +V +  S   Y+D        +++ + +  +  Q++  ++  
Sbjct: 4817 ----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNA 4872

Query: 1191 YETKLCEE-----EAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDE 1245
               K  E+     E + AD   +E+ ++ L +   ++ E      AL         I  +
Sbjct: 4873 LSHKEKEKFTKAKELISAD---LEHSLAELSELDGDIQE------ALRTRQATLTEIYSQ 4923

Query: 1246 MFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDW 1305
              + Y+      DW ++  + L         Q+     D+E   ++LK + + +   D +
Sbjct: 4924 CQRYYQVFQAANDWLEDAQELL---------QLAGNGLDVESAEENLKSHMEFFSTEDQF 4974

Query: 1306 IQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDY 1365
               +E     +    P    T    L Q+   V+ +E++  +M                 
Sbjct: 4975 HSNLEELHSLVATLDPLIKPTGKEDLEQK---VASLELRSQRMSRDSG------------ 5019

Query: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSL 1425
                    A VD  Q+   +    Q + + +I+   D   + +    L T     A + L
Sbjct: 5020 --------AQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKL 5071

Query: 1426 KRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKK 1485
                 E K+L        EK   L++  S + KT  DA KA          S   +  + 
Sbjct: 5072 S----EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKA------TLSRSMTTVWQRW 5121

Query: 1486 EQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1545
             +L    Q  +  L    D+ T    N+++K  + + +  + L   S ++  +++    +
Sbjct: 5122 TRLRAVAQDQEKILEDAVDEWTGFN-NKVKKATEMIDQLQDKLPGSSAEKASKAELLTLL 5180

Query: 1546 KVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQK 1605
            +  +  V E +Q+             Q+   ++  Q   M+ DG         ++  L +
Sbjct: 5181 EYHDTFVLELEQQ-------------QSALGMLRQQTLSMLQDGAAPTP---GEEPPLMQ 5224

Query: 1606 DMQGSAQALAEVVKNTENFLKENGEKLSQE--DKALIEQKLNEAKIKCEQLNLKAEQSKK 1663
            ++     A+ +   N +  +K NG+ + QE  D+ ++E ++N  K   ++          
Sbjct: 5225 EIT----AMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI 5280

Query: 1664 ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQV--IEQN 1721
            E+D                  QLEE +  +    +   N++K +E    K+  +  I  +
Sbjct: 5281 EIDA-----------------QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPS 5323

Query: 1722 GTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV 1781
                Q  +    +   D++   + E +   Q   T + L++Q QK+      I+++ +A 
Sbjct: 5324 ELSLQLAEVALDLKIRDQIQDKIKEVE---QSKATSQELSRQIQKLAKDLTTILTKLKA- 5379

Query: 1782 IIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMK-LTHSLQEELE 1840
                ++  V+  K  Q +  EE +     + EL    +  L ++ +  K L   + +  E
Sbjct: 5380 ----KTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5435

Query: 1841 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG--DLRYIT 1898
                   + E+ L +  Q   +LE   + +  ++  +++ K  +   I+      LR   
Sbjct: 5436 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5495

Query: 1899 ISGNRVLEAAKSCSKRDGGKVD-------TSATHREVQR--KLDHATDRFRSLYSKCNVL 1949
            I    +LE +K          +          T +  Q+  +L   T+  R +     + 
Sbjct: 5496 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIK---IR 5552

Query: 1950 GNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQ--LEETKALQ 2007
              NL+D     + +E     L A L+  +AT +      +++  +   RQ  L E ++L+
Sbjct: 5553 LQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLK 5612

Query: 2008 GQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ 2067
             ++ + Q+    L+   +V+  A   L  A   +Q          E+ S+  +   ++  
Sbjct: 5613 PKVQAVQLCQSALRIPEDVV--ASLPLCHAALRLQ----------EEASRLQHTAIQQCN 5660

Query: 2068 ITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDI---ISKNIMLEQDIAGR 2124
            I     +  +    EM      +E + +E    P+ ++ +Q++   IS++  L Q I G 
Sbjct: 5661 IMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGY 5720

Query: 2125 QSSINAMNEKVKKFMETTDPST-------ASSLQAKMKDLSARFSEASHKHKE----TLA 2173
            Q  I ++N K K        +T          L    +DL          H      T  
Sbjct: 5721 QEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG 5780

Query: 2174 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVT---ELSQYMQESTSEFLEH 2230
            +   L + V   E+  E   + + +     +   V   D +   +++ Y   S       
Sbjct: 5781 RCHTLLSPVTE-ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5839

Query: 2231 KKHLEVLHSLLKEISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLD 2289
               +    S  +E    GL PS  A    K  +L + ++ +++ I EK+  +    E+  
Sbjct: 5840 AAKIHPSTSASQEFYEPGLEPSATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQ 5895

Query: 2290 AFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSG 2349
             +Q  ++S+ + ++    K+    P  G     +  E    + E   L+  EI ++ +S 
Sbjct: 5896 KYQDSLQSISTKMEAIELKLS-ESPEPGRSPESQMAEHQALMDEILMLQD-EINELQSSL 5953

Query: 2350 ISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYE 2409
                   S    PA+ +A   +                      LT + + M+ I     
Sbjct: 5954 AEELVSESCEADPAEQLALQST----------------------LTVLAERMSTIRMKAS 5991

Query: 2410 DLGLLLKDKI---AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPA-PTDTEAV 2465
                LL++K+    E   +   LQ+ + E+  +  WL     T       P  P D EA 
Sbjct: 5992 GKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEA- 6050

Query: 2466 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENP--DTPEAPRWKQMLTEIDSKWQEL 2523
              Q+   ++   E++Q V  + EL      LL E       EA +    L  +     EL
Sbjct: 6051 --QLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108

Query: 2524 NQLTIDRQ-------QKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLN 2576
             +   D+Q       Q+ EES  +LT  Q+   Q  +WL +     +     S+      
Sbjct: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ--EWLAQARTTWTQQRQSSL------ 6160

Query: 2577 TQRQQVQILLQEFATRKPQYEQLTAAGQGILSR---------PGEDPSLR----GIVKEQ 2623
               QQ + L QE A +K     + + G+ IL +          GE P +     G+  E+
Sbjct: 6161 ---QQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEK 6217

Query: 2624 LAAVTQ---KWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL-----DNKLSS 2675
             +A  Q   KW+SL  + S +   + Q +++  Q Q L    +  LS +     D     
Sbjct: 6218 SSAEDQMRMKWESLHQEFSTKQKLL-QNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD 6276

Query: 2676 SLAVSTHPDAMNQQLETAQKM-----KQEIQQEKKQ---IKVAQALCEDL-------SAL 2720
              AV++  D +NQ  E          +Q I  E+K    +       +D+       +AL
Sbjct: 6277 KSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATAL 6336

Query: 2721 VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL---- 2776
            + EE      ++++  + K  K++ ++ + +      A   +   + +  D    L    
Sbjct: 6337 LPEETETCLFNQEI--LAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 6394

Query: 2777 -----------DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
                          KE   +       L VL + + D+K     L   ++++E+ +AE  
Sbjct: 6395 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYI--ILQKLANVFEQPVAEQI 6452

Query: 2826 NLL----------------LKTQGS----EKAALQLQLNTIKTNWDTFNKQVKERENKLK 2865
              +                LK +G     E+ ++Q +L+ ++  +D     +  R + L 
Sbjct: 6453 EAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLN 6511

Query: 2866 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2925
            ++L    +Y+  ++ L   ++  Q  +   +  +  ++ E  I +L    KE  Q     
Sbjct: 6512 QNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE--IQQLLDKHKEYFQGLESH 6569

Query: 2926 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVS 2985
             +L  T    +    + KE  T  +  L+ +   V ++ H +   LE + + +    E  
Sbjct: 6570 MILTETLFRKIISFAVQKE--TQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQ 6627

Query: 2986 KESKRQLQCAKEQLDIHDSLGSQAYSNKYL----TMLQTQQKSLQALKHQVDLAKRLAQD 3041
            +E  RQL+  +  +    S+G    +   L    T+ Q  + SL   + ++       + 
Sbjct: 6628 QELSRQLEVVESSIP---SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6684

Query: 3042 LVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQF 3101
            L++  S     SD+  Q+  + +   + + ++ ++   LET L+    +Q+   ++    
Sbjct: 6685 LLISIS----CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 6740

Query: 3102 AEFDDELD----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEE 3157
                D L+        V ++ E ++        F K+++A  +   +   T   +L  ++
Sbjct: 6741 QSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKK 6800

Query: 3158 TSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGT-IKRLEEFY--SKLKEFSILLQKA 3214
               D   ++ +L  +  Q   LL    A +E++    + +L   +  S++  +  L++  
Sbjct: 6801 V--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6858

Query: 3215 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3274
             + +E      +  + I++ L  +K F+ +    +  KQ  V+++ Q ++Q +++   ++
Sbjct: 6859 IQKDEDNIKNSIGYKAIHEYLQKYKGFKID----INCKQLTVDFVNQSVLQISSQDVESK 6914

Query: 3275 GLE-----HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3329
              +       L  +N  W+ L   V ++   L+  L     +++ ++ L +W  +T+E  
Sbjct: 6915 RSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWF-ETQEKR 6973

Query: 3330 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3389
              Q+    +   V+  +++ + L+ L+  ++  VE I++ G  +    +      ++  L
Sbjct: 6974 LKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTL 7033

Query: 3390 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3449
              L   W  L +        L+ +           + +N +L      L     +     
Sbjct: 7034 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7093

Query: 3450 KLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSSREDKDMVQSKLDFSQVW---Y 3505
             ++ Q+   + L+DD+    + L +  SI  Q LK       + +  +  + +  W    
Sbjct: 7094 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7153

Query: 3506 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS 3565
             EI E+  S   LLQ                  + +      S +  Q+  T  L K  +
Sbjct: 7154 EEIAEQLQSSKALLQL--------------WQRYKDYSKQCASTVQQQEDRTNELLKAAT 7199

Query: 3566 ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3625
               +  +++    Q+ +  LL GL  +K    D +  + +  E +K +      +    A
Sbjct: 7200 NKDIADDEVATWIQDCND-LLKGLGTVK----DSLFFLHELGEQLKQQ------VDASAA 7248

Query: 3626 KTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSYET----------------QVLKGEE 3668
              ++   L L++ L +  + LC     ++  +L YET                ++L+G++
Sbjct: 7249 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQD 7308

Query: 3669 ASQA------QMRPKELKKEAKNNKAL---LDSLNEVSSALLELVPWRAREGLEKMVAED 3719
             S +      Q R +ELK +     ++   LD LNE+   L    P   +E   K +   
Sbjct: 7309 PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL----PLNDKE--IKRMQNL 7362

Query: 3720 NERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3779
            N  + L+S   T++  ++ + +L+ Q F +  +  + ++ +TE+KL    +I        
Sbjct: 7363 NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLL 7420

Query: 3780 AQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQIN 3839
             Q +  + F  E+   + I+  ++  G +++     +++     KL  +   +  + +  
Sbjct: 7421 EQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRA 7480

Query: 3840 SERYLQLERAQSLVNQFWETYEELWPWLTETQSI----ISQLPAPALEYETLRQQQEEHR 3895
             +R   ++       ++ E  E+L  WL E   +    +  +P P  +  TL  + +   
Sbjct: 7481 QQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE 7540

Query: 3896 QLRELIAEHKPHIDKMNKTGPQLLELSPG-------EGFSIQEKYVAADTLYSQIKEDVK 3948
            ++   + +   +I  +      LL    G       E   IQEK+ +A     +++E  K
Sbjct: 7541 KV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM---RLEEQKK 7595

Query: 3949 KRAVALDEAISQSTQFHDKIDQILESLERIVERLRQP-PSISAEVEKIKEQISENKNVSV 4007
            K A  L +         D ++++    +++ + L      + AE  + KE  +   + + 
Sbjct: 7596 KLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTD 7655

Query: 4008 DMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKL 4067
            D+ +L  L +TL        A     D  I    + ++++ +   WE +   +  R  ++
Sbjct: 7656 DLTQLSLLKDTLS-------AYISADDISI----LNERVELLQRQWEELCHQLSLRRQQI 7704

Query: 4068 LDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE 4127
             + +     F   +  L   +   +  +    D  I+  + K +++     +EEI   QE
Sbjct: 7705 GERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKD----YQEEIAIAQE 7760

Query: 4128 ELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQ 4187
                +  +G  L  A  E     ++  + ++N  W  L      R+ KL+E + A  Q  
Sbjct: 7761 NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLD 7820

Query: 4188 DGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQQIEELKQFKSEAYQQQIEMERLNHQ 4244
              + ++  W+     +LA   PI  D    E +++++ E ++ + +  +    +  + + 
Sbjct: 7821 KNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL 7878

Query: 4245 AELLLKKV---TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4301
             E+LL        +++  ++Q     L   W ++    + R+ K+E       +F     
Sbjct: 7879 CEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYS 7938

Query: 4302 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4361
                WL  +E   +     G      + EL K    Q  V    + +E +NK    L   
Sbjct: 7939 RFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE 7998

Query: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421
            +  + A +L+  +   NQRW N+ ++     ++L   + Q + F    + +  WLT+ + 
Sbjct: 7999 NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 8058

Query: 4422 HLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNID 4480
             L   +        AK +QL    +  +    K E    ++ +G+Q++ +        I+
Sbjct: 8059 QLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE---QIIAQGEQLIEKSEPLDAAIIE 8115

Query: 4481 QDINNLKEKWESV-------------------ETKLNERKTKLEEALNLA-MEFHNSLQD 4520
            ++++ L+   + V                   E  L++R+ +LE++  L+ + +H+   D
Sbjct: 8116 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSAD 8175

Query: 4521 FINWLTQAEQTLNVASRPSL-----------ILDTVLFQIDEHKVFANEVNSHREQIIEL 4569
             +    Q    L+++    L            +D++  + D     + ++ S   + +  
Sbjct: 8176 SL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPS 8234

Query: 4570 -DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDA-RKRAKQFHEAW 4627
             D+ G   K F  +  V L   ++      + K+ +  ++       A   + +Q  +A 
Sbjct: 8235 EDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKAL 8294

Query: 4628 SKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKE 4687
                  ++++E  + S+     + D        +K + K LG   S  D+  R    LKE
Sbjct: 8295 DDSRFQIQQTENIIRSKTPTGPELD------TSYKGYMKLLGECSSSIDSVKRLEHKLKE 8348

Query: 4688 KTSLADDNLKL---DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWL 4744
            +       + L   +   + + D+W+ +  +++ ++ ++++ L    QF   L ++  WL
Sbjct: 8349 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWL 8408

Query: 4745 YRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDD 4802
               E +L + Q +    DI  +   I   K  QK +  R + + ++   + E  +    +
Sbjct: 8409 GDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE 8468

Query: 4803 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4862
            S  ++ ++ +++ RW+ VC+L    +  L+ AL Q + FH + H LL  L   ++  R +
Sbjct: 8469 SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKN 8526

Query: 4863 GVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAELNKATTMGDTVLAICHPDSITTIKHW 4918
             ++P D +     L D HK+ M+   +L E +  +     M   +L           K  
Sbjct: 8527 EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 8586

Query: 4919 ITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4953
            + +I  R + +L    +H + L   L    ++Q+L
Sbjct: 8587 VHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8621



 Score =  286 bits (731), Expect = 5e-76
 Identities = 864/4710 (18%), Positives = 1776/4710 (37%), Gaps = 672/4710 (14%)

Query: 360  KEWGKLIIAMLEREKA--LRPEV-ERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK 416
            +E G+  +  LE  +A  LR E+ + +E L+++ + V+++ +  E  L LA        K
Sbjct: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA-KEFSDKCK 3811

Query: 417  RLESGVQ----------------FQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQAD 460
             L   +                 ++ +A+++ Y       L+Q V+  +  +     + +
Sbjct: 3812 ALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----KSLQQTVLSHEPSVKSVREKGE 3866

Query: 461  QLVQRV--AKLRDEIMALRNECSSVYSKGRILTTE-------------QTKLMISGITQS 505
             L++ V    L+D+I  L+++   + S G+ +  E             +   +I      
Sbjct: 3867 ALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH 3926

Query: 506  LNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVP 565
            L +   Q +H  L            T+  M   L   +   ++   T      + S + P
Sbjct: 3927 LQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQP 3986

Query: 566  NFSSGVEPNSLQTLKLMQIR-----------------------KPLLKSSLLDQNLTEEE 602
            +     +P   +   + Q++                          +K++  D   TE+ 
Sbjct: 3987 DLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQT 4046

Query: 603  INMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 662
            I  K VQ         +++  ++E    L   +  L+N K  H    E E ++ +  +S+
Sbjct: 4047 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH---SELELNIAQNMVSQ 4103

Query: 663  IQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 722
            ++          + + +L+S+ A +               N +    N+L    +KEE  
Sbjct: 4104 VK----------DFVKKLQSKQASV---------------NTIIEKVNKL---TKKEE-- 4133

Query: 723  VAYDWSERNTNIARKKDYHAELMRELD----QKEENIKSVQEIAEQLLLENHPARLTIEA 778
                 S  +  I    D   +L R+ +    Q+EE+++  ++         H     +E 
Sbjct: 4134 -----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDY--------HDCMNVVEV 4180

Query: 779  YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD---AIQRKYSCD 835
            +     T+W  + +                   +DA+    +L  LK    A+Q     +
Sbjct: 4181 FLEKFTTEWDNLAR-------------------SDAESTAVHLEALKKLALALQ-----E 4216

Query: 836  RSSSIHKLEDLVQESME-----EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 890
            R  +I  L+D  Q+ +E     +KE + +  S +     + + +I+ K            
Sbjct: 4217 RKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKI----------- 4265

Query: 891  PIKAICDYRQIEITIYKDDECVLANNSHRAKW-KVISPTGNEAMVPSVCFTVPPPNKEAV 949
                     Q+ +T  ++   V +      +W +   P   EA+  S     PPP     
Sbjct: 4266 ---------QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQS-----PPP----- 4306

Query: 950  DLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPG------ 1003
            D+A  +   +  + +      + +KS      LI + DR+ A    + + ++        
Sbjct: 4307 DMAQNLLMDHLAICSELEAKQMLLKS------LIKDADRVMADLGLNERQVIQKALSDAQ 4360

Query: 1004 EHQQVLSNLQSRFEDFLED--SQESQ----VFSGSDITQ------------------LEK 1039
             H   LS+L  +   +L    S+++Q    VF  +   Q                  + K
Sbjct: 4361 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4420

Query: 1040 EVNVCK------QYYQ-----------ELLKSAEREEQEE------SVYNLYISEVRNIR 1076
            +V  CK      + YQ           EL+K    +E+ E       + ++Y S ++   
Sbjct: 4421 QVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCS 4480

Query: 1077 LRLENCEDRLIRQIRTPLERDD----LHESVFRITEQEKLKKELERLKDDLGTITNKCEE 1132
             RL+  E  L+ +     + D     L ++      +  L  E   L   L    N  E+
Sbjct: 4481 HRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ 4540

Query: 1133 --------FFSQAAASSSVPTLRS--------ELNVVLQNMNQVYSMSSTYIDKLKTVNL 1176
                       Q    + +P+L          +LN + +  N + +++    DK   V  
Sbjct: 4541 SPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK---DKFYKVQE 4597

Query: 1177 VLKNTQAAEALVKLYETKLCEEEAVIADKNNI------ENLISTLKQWRSEVDEKRQVFH 1230
             +   +   +L++L    L E EA     + +      E  +S     R+ +DE   +  
Sbjct: 4598 AILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGE 4657

Query: 1231 ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1290
            A+++  QK +            R     W  +K   LV  +  +  Q + R+  LE    
Sbjct: 4658 AVDELNQKKEGF----------RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTS 4707

Query: 1291 SLKYYRDTYHPLDDWIQQVETTQRKI-QENQPENSK-----TLATQLNQQKMLVSEIEMK 1344
            + + +      L+  ++ V+  Q K+ +E  P   K     +LA  L    +++  + + 
Sbjct: 4708 AYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4767

Query: 1345 QSKMDE------CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1398
               +         +K   Q  +   + +L T      V   +   V+    Q+     + 
Sbjct: 4768 LEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD 4827

Query: 1399 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
                ++   +  V L          +L+ ++EE + ++  ++E V+ +  +   +S+   
Sbjct: 4828 WLRRVKAELSGPVYLDL--------NLQDIQEEIRKIQIHQEE-VQSSLRIMNALSH--- 4875

Query: 1459 TLKDAEKAGKPPFSKQKISSE------EISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1512
              K+ EK  K   +K+ IS++      E+S     + EAL+T Q  L         E  +
Sbjct: 4876 --KEKEKFTK---AKELISADLEHSLAELSELDGDIQEALRTRQATLT--------EIYS 4922

Query: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
            + ++  +  Q + + L  ++ + LQ +    DV+  E+ +    + +  + Q   +L  +
Sbjct: 4923 QCQRYYQVFQAANDWL-EDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNL--E 4979

Query: 1573 TENRLIGHQEAFMIGDGTVELKK----YQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1628
              + L+   +  +   G  +L++     + + + + +D       L        ++ K  
Sbjct: 4980 ELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR 5039

Query: 1629 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1688
             E +   +    E+KL+E  +     + +AE+   E  K + + +    EK+ A   LEE
Sbjct: 5040 EEVIELMNDT--EKKLSEFSLLKTSSSHEAEEKLSE-HKALVSVVNSFHEKIVA---LEE 5093

Query: 1689 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1748
              +++E           D+ +A            T +Q      A+ ++ E    +LE  
Sbjct: 5094 KASQLEK-------TGNDASKATLSRSMT-----TVWQRWTRLRAVAQDQE---KILEDA 5138

Query: 1749 VD------GQVGTTQENLNQQYQKV---------KAQHEKIISQHQAVIIAT---QSAQV 1790
            VD       +V    E ++Q   K+         KA+   ++  H   ++     QSA  
Sbjct: 5139 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5198

Query: 1791 LLEKQ-------GQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---E 1840
            +L +Q       G   +P E+  L   M+E+    +  L   EK       +++EL   E
Sbjct: 5199 MLRQQTLSMLQDGAAPTPGEEPPL---MQEITAMQDRCLNMQEKVKTNGKLVKQELKDRE 5255

Query: 1841 KFDADYTEFEHWLQQSEQELEN----LEAGADDINGLMTKLKRQKSFSEDVISHKGD--L 1894
              +      + W+Q++++ L N    ++A  +++  L+T+    +   E +   + +  L
Sbjct: 5256 MVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL 5315

Query: 1895 RYITISGN----RVLEAAKSCSKRDG-----GKVDTS-ATHREVQRKLDHATDRFRSLYS 1944
               TI  +    ++ E A     RD       +V+ S AT +E+ R++        ++ +
Sbjct: 5316 GLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILT 5375

Query: 1945 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2004
            K     +N+       +   +   G  + L   +A   K L +   +     ++  + T+
Sbjct: 5376 KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5435

Query: 2005 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS-VNERN 2063
              Q  I   +  + KL + A  L +    L      I+K      G     S S + E+ 
Sbjct: 5436 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5495

Query: 2064 EKLQITLTRSLSVQDGLDEM---LDWMGNVESSLKEQGQVP---LNSTALQDIISKNIML 2117
               Q  L  S  +   L+ M   L ++ +V  + K   QV      +  L+ +I   +  
Sbjct: 5496 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5555

Query: 2118 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2177
             QD A       A  +K++  +E    +T +S +     L  + S   H     L++ME 
Sbjct: 5556 LQDAAKDMKKFEAELKKLQAALEQAQ-ATLTSPEVGRLSLKEQLSHRQH----LLSEMES 5610

Query: 2178 LKTKVELFE------NLSEKLQTFLETKTQALT-EVDVPGKDVTELSQ--YMQESTSEFL 2228
            LK KV+  +       + E +   L     AL  + +      T + Q   MQ +  ++ 
Sbjct: 5611 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE 5670

Query: 2229 EHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2288
            ++++ ++ L  L++   +H    DK +       L  +    E    E  + +   QEQ+
Sbjct: 5671 QYEQEMKHLQQLIE--GAHREIEDKPVATSNIQELQAQISRHE----ELAQKIKGYQEQI 5724

Query: 2289 DAFQVLVKSLKSWIKETTKKVPIVQP---SFGAEDLGKSLEDTKKLQEKWSLKTP----- 2340
             +     K L    K  T  + + +    + G EDL   L  T        + T      
Sbjct: 5725 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 5784

Query: 2341 --------EIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA---VLNGEGTATN----- 2384
                      ++  NS IS      + +  A   A+V    A    L+ E   T+     
Sbjct: 5785 LLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIH 5844

Query: 2385 -----TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2439
                 ++EF+      S    + D+   +E L  ++ +K   L   L + QK Q+   ++
Sbjct: 5845 PSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSI 5904

Query: 2440 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE-LLE 2498
                 KM     K  ++P P    + ++Q+ ++++   E+    +++ EL+  L E L+ 
Sbjct: 5905 ST---KMEAIELKLSESPEPG--RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959

Query: 2499 EN--PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ--- 2553
            E+   D  E    +  LT +  +   +      ++Q LEE  N+  + Q  E  L++   
Sbjct: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRC 6019

Query: 2554 -------WLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605
                   WL+  K  + + L P   +P  +  Q    Q +L E   +     +L+   + 
Sbjct: 6020 EADELDSWLLSTKATLDTALSPPK-EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078

Query: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665
            +L         +   K++   +  K   L G L +      Q  +   Q      +   +
Sbjct: 6079 LLLEG------KAHTKDEAEQLAGKLRRLKGSLLEL-----QRALHDKQLNMQGTAQEKE 6127

Query: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2725
             SD+D   + S  V    + + Q   T  + +Q   Q++K+++  Q L E  S L     
Sbjct: 6128 ESDVDLTATQSPGVQ---EWLAQARTTWTQQRQSSLQQQKELE--QELAEQKSLLRSVAS 6182

Query: 2726 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2785
               E+  Q     ++  D  +K +   Q L      S    QM      W    +E    
Sbjct: 6183 RGEEILIQ-HSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR---MKWESLHQE---- 6234

Query: 2786 SHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 2845
                S K  +L+++++  +             E+ +    N LL      K  +  Q  +
Sbjct: 6235 ---FSTKQKLLQNVLEQEQ-------------EQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278

Query: 2846 IKTNW-DTFNKQVKERENKL----KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
              T+  D  N+  +E  ++     ++S+    K  + V     W+D  +  L  +   L 
Sbjct: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLF-VATALL 6337

Query: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2960
            P E E  +   + L K++ +    ++   N  +        +++V+ D    L+ ++ ++
Sbjct: 6338 PEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL 6397

Query: 2961 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQT 3020
               ++ +   ++   Q+   FQ   K                  L +    NKY+ + + 
Sbjct: 6398 DSVVNQRCHQMKERLQQILNFQNDLKV-----------------LFTSLADNKYIILQKL 6440

Query: 3021 QQKSLQALKHQVDLAKRLAQDLVVEAS----DSKGTSDVLLQVETIAQEHSTLSQQVDEK 3076
                 Q +  Q++  ++ A+D + E      + K   D L   +   QE S L    DE 
Sbjct: 6441 ANVFEQPVAEQIEAIQQ-AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 6499

Query: 3077 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-----DAETLQKQKETIKAF 3131
               + ++  G+    N    + SQ+     +L  +   G+     D + +   KE I+  
Sbjct: 6500 MMIIGSRRSGL----NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQL 6555

Query: 3132 LKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEA-----LSKQCNKLLDRAQAR 3186
            L K +      ++       M+ TE     ++      E      L  Q + +L RA  R
Sbjct: 6556 LDKHKEYFQGLESH------MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR 6609

Query: 3187 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGP-VGMETETINQQLNMFKVFQ--K 3243
              ++E  +    E +S L E    L +  E  ES  P VG+  E  ++ ++   ++Q  K
Sbjct: 6610 GVELEYIL----ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6665

Query: 3244 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3303
              +   Q K   V   G+ L+ S     S   LE  L+ +   W +   K+++   +L+ 
Sbjct: 6666 SSLNEYQPKLYQVLDDGKRLLISI----SCSDLESQLNQLGECWLSNTNKMSKELHRLET 6721

Query: 3304 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVKAQIQEQKLLQRLLDDR 3359
             L H  R+Q     L+ W+   ++ +      S     E ++V+  +       + +D +
Sbjct: 6722 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6781

Query: 3360 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3419
             S    +   G ++    +  D   +  +LS +DS+W  LL        +L  + +    
Sbjct: 6782 SSLKSSVLSTGNQLLRLKK-VDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 6840

Query: 3420 FHETLEPLNEWLTTIEKRLVNCEP-----IGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
                +  +  W++ +E  +   E      IG +A  + E + ++K  + DI   N     
Sbjct: 6841 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKIDI---NCKQLT 6895

Query: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQV-------WYIEIQEKSHSRSELLQQALCNAK 3527
               + QS+  +SS++ +     K DF++        W I +Q     + +LL+  L +  
Sbjct: 6896 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQI-LQGLVTEKIQLLEGLLESWS 6954

Query: 3528 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3587
             + E+ V+ +    E  +K  K   +      +     + + L++ I  +++ V++   N
Sbjct: 6955 EY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7013

Query: 3588 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3647
            GL L++    D   I+   L  +   + ++  +   +   L+  L          +++ +
Sbjct: 7014 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7073

Query: 3648 WLDKVEVELLSYETQVLKGE-EASQAQM-RPKELKKEAKNNKALLDSLNEVSSALLELVP 3705
            +L +    L  +  ++L G  EA Q Q+   + L+ + +  +  L     +++ LL+   
Sbjct: 7074 YLMEARYSLSRF--RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7131

Query: 3706 WRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL 3765
                E L   + E N R+  + + I ++++   A +   Q++   +    S + + E + 
Sbjct: 7132 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7191

Query: 3766 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825
              L      +D    ++        ++L+    + D +   H++     ++   S    +
Sbjct: 7192 NELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAI 7251

Query: 3826 DK-VLKNYDTICQINSERYLQLERAQSLV---NQFWETYEELWPWLTETQSIIS-QLPAP 3880
                L     +C +      Q    Q+ V     F ++ E L  W+ E + I+  Q P+ 
Sbjct: 7252 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 7311

Query: 3881 ALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY 3940
            + +  T++++ EE +      +   P +D++N+ G +L  L+  E   +Q      +  +
Sbjct: 7312 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-PLNDKEIKRMQN----LNRHW 7366

Query: 3941 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQIS 4000
            S I     +R   L   + Q   F +K +  +E L +  ++L     IS   + + EQ  
Sbjct: 7367 SLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQR 7424

Query: 4001 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4060
             ++    +M   Q +  ++   G+ ++ +    D+D        KL  +   W+ +    
Sbjct: 7425 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLKLTLLSNQWQGVIRRA 7480

Query: 4061 EEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4120
            ++R      +++   + W  +  +   ++     +  L   G+    +  QQ  A T+ +
Sbjct: 7481 QQRRG----IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ--ARTLFD 7534

Query: 4121 EID-------GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4173
            E+          Q    + +  G +L+ +     +  ++  + E+   W S +   +++ 
Sbjct: 7535 EVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQK 7594

Query: 4174 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4233
             KL   ++             DW     G   S+  + T  + + Q + +  +   E + 
Sbjct: 7595 KKLAFLLK-------------DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE---ELHA 7638

Query: 4234 QQIEMERLNH----------QAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERII 4280
            +Q+  + L +          Q  LL   L       D   + + +  L+  W+ L  ++ 
Sbjct: 7639 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7698

Query: 4281 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE-IELAKHHVLQN 4339
             R+ ++   L     F     EL  WLT  E  +S+     GD    E IE  K    + 
Sbjct: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN----GDILIEEMIEKLKKDYQEE 7754

Query: 4340 DVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4399
              +A ++ ++ + + G  L ++S   +AS ++ KL  +N RWQ++L+    R ++L   L
Sbjct: 7755 IAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813

Query: 4400 RQAKGFHGEIEDLQQWLTDTERHLLASKPL---GGLPETAKEQLNVHMEVCAAFEAKEET 4456
               +     +  L+ WL   E  L  +KP+       E  + +LN   E+    E     
Sbjct: 7814 VAVQQLDKNMSSLRTWLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871

Query: 4457 YKSLMQKGQQMLARCPKSAET----NIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4512
              S++   + +L  C   A      +I Q   NL  +W ++     ER+ K+EE   L  
Sbjct: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931

Query: 4513 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4572
            +F +    F +WL  +E+T    S   +I      ++ + + F  +V+    Q+  ++K 
Sbjct: 7932 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991

Query: 4573 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4632
               L   ++      +K ++     RW+ + +R+    R L     + ++F  A   ++ 
Sbjct: 7992 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8051

Query: 4633 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4692
            WL E +  L + +E  ++ D ++ ++ Q K FQ+ +   H+  +     G  L EK+   
Sbjct: 8052 WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPL 8109

Query: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNK 4722
            D  + +++ L ELR     + G+ VER +K
Sbjct: 8110 DAAI-IEEELDELRRYCQEVFGR-VERYHK 8137



 Score =  281 bits (719), Expect = 1e-74
 Identities = 768/4289 (17%), Positives = 1651/4289 (38%), Gaps = 539/4289 (12%)

Query: 1005 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1064
            HQQ    + ++  D  +   ++Q   G    +  +E+   +     L +S ER+E+   V
Sbjct: 1285 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1344

Query: 1065 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1121
                   +R    R E  ++ ++R +    +    HE     +  E L  ELE+ K+   
Sbjct: 1345 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1394

Query: 1122 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1180
               +I  + E    +A+     P  +  L    +++  QV  +  T  + +KT+ +V   
Sbjct: 1395 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1454

Query: 1181 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1236
                 +  +     + E+E    A+    + ++  IS +K    E++ K      LE+E 
Sbjct: 1455 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1514

Query: 1237 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1296
            Q     S   F T  E                        +I  +L  +   G+ L+ + 
Sbjct: 1515 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1547

Query: 1297 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1349
                 L+  I       Q+ E   RKIQ++  E    LA  +          ++ Q  MD
Sbjct: 1548 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1604

Query: 1350 ECQKYAEQYSATV-------KDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEF 1400
             CQ      SA         K     +    A    QQ   + RR    Q++ + ++  +
Sbjct: 1605 LCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHW 1664

Query: 1401 MDLRTRYTALVTLM--------TQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA----KE 1448
              L    ++ +T +        +  +  + D +K +E E + ++  + E V +A    K 
Sbjct: 1665 QRLEKELSSFLTWLERGEAKASSPEMDISADRVK-VEGELQLIQALQNEVVSQASFYSKL 1723

Query: 1449 LQKWVSNISKTLKDAEKAGK-------------PPFSKQKIS-SEEISTKKEQLSEALQT 1494
            LQ   S  S   KD  K  K             P    ++I+  + +  + +Q  E L +
Sbjct: 1724 LQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1783

Query: 1495 ----IQLFLA------------------KHGDKMTDEE--RNELEKQVKTLQESYNLLFS 1530
                I+LFL+                  +H D   + E  + EL+     L +  +L  +
Sbjct: 1784 FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRA 1843

Query: 1531 ESLKQLQ-ESQTSGDVKVEEKIVAERQQ----------EYKEKLQGICDLLTQT------ 1573
            E L  LQ +++    +  E   V ER+Q          +    L GI   L QT      
Sbjct: 1844 EDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNS 1903

Query: 1574 ----ENRLI------------GHQEAFMIGDGTVELKKYQSK--QEELQKDMQGSAQALA 1615
                E+ LI              + A +  DG +   +Y  K    E +   + +A  L 
Sbjct: 1904 MNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLC 1963

Query: 1616 EVVKNTENFLKENGEKLSQEDK-ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIK 1674
              V+  +N L   G K S+ D  A++++   + K   E+L    E  ++  DK     +K
Sbjct: 1964 GEVERIQNLL---GTKQSEADALAVLKKAFQDQK---EELLKSIEDIEERTDK---ERLK 2014

Query: 1675 EET-----EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGD 1729
            E T     +++    QLE+     E+ L WL +          K KQ+ +++        
Sbjct: 2015 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKD----------KAKQIAQKD-------- 2056

Query: 1730 GKSAIGEEDEVNGNLLETDVDGQVGTTQEN---------LNQQYQKVKAQHEKIISQHQA 1780
               A   E +   N LE   D       EN         L ++YQ +K+   K++    +
Sbjct: 2057 --VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114

Query: 1781 VIIATQSAQVLLEKQGQYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 1839
            VI+   + +   + +  +   E  K K+    K+L  ++ +       ++K  HS    L
Sbjct: 2115 VIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLD-NFTSKGKHLLSELKKIHSSDFSL 2173

Query: 1840 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1899
             K D + T  + WL  SE+  EN           M +L+   S  +DV+S + ++     
Sbjct: 2174 VKTDMEST-VDKWLDVSEKLEEN-----------MDRLRVSLSIWDDVLSTRDEIE--GW 2219

Query: 1900 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK----- 1954
            S N V + A++ S  D   +      +E + ++ +   R   L+SK N L    K     
Sbjct: 2220 SNNCVPQMAENISNLD-NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETP 2278

Query: 1955 --------DLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPIAVDPK--------- 1994
                    DL+ K +H +   + + G L    A      K +++      K         
Sbjct: 2279 PDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA 2338

Query: 1995 --NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2052
                   L++ K +Q ++ SQQ  +   ++    L   R         + + +  ++ ++
Sbjct: 2339 QNETCEALKKVKDIQKELQSQQSNISSTQENLNSL--CRKYHSAELESLGRAMTGLIKKH 2396

Query: 2053 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2112
            E +S+  ++    LQ +L +  S  + + E  +W    +++ KE      +S  L+  + 
Sbjct: 2397 EAVSQLCSKTQASLQESLEKHFS--ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2454

Query: 2113 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2172
                +   ++  QS ++A+ ++ +           SS+Q ++   +  F     +  +  
Sbjct: 2455 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2514

Query: 2173 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 2232
              +++  +++  FE+   KL  ++    +         +++ E  Q++ E  +E   HK 
Sbjct: 2515 QALQDCASELGSFEDQHRKLNLWIHEMEERFNT-----ENLGESKQHIPEKKNEV--HKV 2567

Query: 2233 HLEVLHSLLKEISSHGLPSDKALVLEKTNN--------LSKKFKEMEDTIKEKKEAVTSC 2284
             +  L  LL    S    S +  +L +  +         S+     ++ ++  KE + SC
Sbjct: 2568 EM-FLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSC 2626

Query: 2285 QEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAED-LGKSLEDTKKLQEKWSLKTP 2340
            Q  L   + L ++L+S   W+K    ++   + + G++D L K L    ++Q+   +K  
Sbjct: 2627 QVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGE 2683

Query: 2341 EIQKVNNSGISLCNLISAVTTPAKAI-AAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2399
               K+N           A+    +A+ ++ K G  V+  +      +E WA+   +S+  
Sbjct: 2684 GEVKLN----------MAIGKGEQALRSSNKEGQRVIQTQ--LETLKEVWADIMSSSVHA 2731

Query: 2400 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2459
              T                   L + +S+     E  + + QW++ +++      Q P P
Sbjct: 2732 QST-------------------LESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ-PQP 2771

Query: 2460 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2519
               E     ++  +S  +E + +   +  L  K  EL E+  D       ++   E+ ++
Sbjct: 2772 GLKEKF-VLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQE---ELKTQ 2827

Query: 2520 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2579
            + ++  +  ++ +K+EE   +   +     +   WL   +  +     +S D +    + 
Sbjct: 2828 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2887

Query: 2580 QQVQIL----------LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2629
             +++ L          L    +  P+ +Q T A  G      E  +LR   K+   +V Q
Sbjct: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTA-SGCELMHTEMQALRADWKQWEDSVFQ 2946

Query: 2630 KWDSLTG----------QLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2679
                L            + S +   ++QA+    Q+ +LL++ + +L+ L+ K +    V
Sbjct: 2947 TQSCLENLVSQMALSEQEFSGQVAQLEQAL---EQFSALLKTWAQQLTLLEGKNTDEEIV 3003

Query: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2739
                    + L+  QK +   +  K Q+        DLS            S ++ G++K
Sbjct: 3004 ECWHKG-QEILDALQKAEPRTEDLKSQLNELCRFSRDLST----------YSGKVSGLIK 3052

Query: 2740 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2799
             +  +  +A    Q+ +       +F++  RDFQ WL   K    K   I   +  + + 
Sbjct: 3053 EYNCLCLQASKGCQNKEQIL--QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTS 3110

Query: 2800 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2859
            ++  ++F        H     +++GE L       +   +Q ++   K +W  F+  + +
Sbjct: 3111 LQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQ 3170

Query: 2860 RENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCL-DPAEGENSIAKLKSLQKEM 2918
            +E+ L+    +   ++   E +  W+ K +  + E    L D         KL+S+ +E+
Sbjct: 3171 KESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI 3230

Query: 2919 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT-QK 2977
              +   +  L   A  L             E ++  +       QL S+   L N+T +K
Sbjct: 3231 HCYEPQLNRLKEKAQQLW------------EGQAASKSFRHRVSQLSSQYLALSNLTKEK 3278

Query: 2978 FKEFQEVSKESKRQLQCAKEQLD-----IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV 3032
                  +  E  +     KE  D     IH  L S  +     ++L ++   L+AL   V
Sbjct: 3279 VSRLDRIVAEHNQFSLGIKELQDWMTDAIH-MLDSYCHPTSDKSVLDSRTLKLEALL-SV 3336

Query: 3033 DLAKRLAQDLVVEASDS-------KGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ 3085
               K +   ++V   +S       +G   +  Q++++    ++L        S LE  L 
Sbjct: 3337 KQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3396

Query: 3086 GIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNA 3145
                +Q+ +R    QF+ + D +++            + K T+    K L   + S  + 
Sbjct: 3397 KWTSYQDGVR----QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSL 3452

Query: 3146 NKTCKMMLA--TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3203
             +T ++  A  TE     L     +L+ L ++   + +RA+    + E  ++  +E+   
Sbjct: 3453 LETIEVKGAGMTEHYVTQL-----ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3507

Query: 3204 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3263
            LK F + L + +E  +    +  +  T    L   +  Q    E            GQ L
Sbjct: 3508 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAE------------GQAL 3555

Query: 3264 IQS-------AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
            + S          S   Q  +  L+ +   W+    ++++   Q    +      +   +
Sbjct: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615

Query: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATT 3376
             +  W+   EE   +++  +   +V +   + Q++L     + +   +  +      A  
Sbjct: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675

Query: 3377 AEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-----------ETL 3424
             +  +++K L +++  L+    +L + ++      +    VA +             +TL
Sbjct: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735

Query: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL----------HQ 3474
            E L + +      L +    G +A K  E+  + + L  +I +H + L          H 
Sbjct: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEE-GEAERLRKEIHDHMEQLKELTSTVRKEHM 3794

Query: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI------EIQEKSH--SRSELLQQALC-- 3524
             +  G  L    S + K + Q   ++ ++ ++      E+ EK    S+ + LQQ +   
Sbjct: 3795 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH 3854

Query: 3525 --NAKIFGEDEVELMNWLNEV--HDKLSKL--SVQDYSTEGLWKQQSELRVLQEDILLRK 3578
              + K   E    L+  + +V   DK+ +L    QD  + G        + + E+I   +
Sbjct: 3855 EPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIG--------KAMMEEIAGFE 3906

Query: 3579 QNVDQALLNGLELLKQTTGDEVLIIQDK----LEAIKARYKDITKLSTDVAKTLEQALQL 3634
              ++   + G  L+ Q        ++      L+  K  Y  I   +  + ++LE  LQ 
Sbjct: 3907 DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 3966

Query: 3635 ARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3694
                  T ++   WL  V+ +L       L   EA +     + L+++A+    LL S+ 
Sbjct: 3967 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMC 4026

Query: 3695 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3754
            ++S+A ++      ++       +  E+  + +  +TQ  EEI         + Q AD +
Sbjct: 4027 DLSNASVKTTAKDIQQ-----TEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQ 4081

Query: 3755 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3814
            L    +  K+  S  ++ + Q+  S   QV K F  ++   +  ++ +++  +K+    +
Sbjct: 4082 L----QNMKRRHSELELNIAQNMVS---QV-KDFVKKLQSKQASVNTIIEKVNKL----T 4129

Query: 3815 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLER----------AQSLVNQFWETYEELW 3864
            ++E+    K+++ +   +  +C+ ++   LQ E             ++V  F E +   W
Sbjct: 4130 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4189

Query: 3865 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
              L  + +  + +   AL+   L  Q+ ++  + +L  + +  I+ +N    +L++    
Sbjct: 4190 DNLARSDAESTAVHLEALKKLALALQERKY-AIEDLKDQKQKMIEHLNLDDKELVKEQTS 4248

Query: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984
                +++++   + L   IK  ++     L+E     ++F + ++   E    I E L+Q
Sbjct: 4249 H---LEQRWFQLEDL---IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ 4302

Query: 3985 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4044
             P      +  +  + ++  +  ++E  Q L ++L +  + ++A  G  ++ +  KA+ D
Sbjct: 4303 SP----PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358

Query: 4045 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4104
                +      +  LV +R   L   +    +F          I+  +  I   E   + 
Sbjct: 4359 AQSHV----NCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414

Query: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4164
            P  V +Q +  ++ +  +   Q E+  +   G EL+    E +K  V   + EL S +DS
Sbjct: 4415 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474

Query: 4165 LNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV---DIAGGKLASMSPIGTDLETVKQQI 4221
            + +    R+ +LE+ + +   +++       W+   DI      ++    ++L T   Q+
Sbjct: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHT---QL 4531

Query: 4222 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4281
             + +    ++ + +  +  L    + +L  +  E D   + + L  L   ++ +     +
Sbjct: 4532 AKYQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKD 4590

Query: 4282 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341
            + +K++ A+LA  ++   ++     L+  E        V  D  A+E  L+    LQ+  
Sbjct: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD-LAVEEALS----LQDGC 4645

Query: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4398
             A    V  + +A ++L +   G  ++      +K+  L   +  +  +TEQR   L+  
Sbjct: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDT 4705

Query: 4399 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4458
                +      + L++ L   +        +      A+E+L ++  +  + +      K
Sbjct: 4706 TSAYQEHEKMCQQLERQLKSVKEE---QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLK 4762

Query: 4459 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4518
             +    + +       A       I + + + + + + + E  T+ E  +  +++F   +
Sbjct: 4763 RVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEM 4822

Query: 4519 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4578
               ++WL + +  L+      L L  +  +I + ++   EV S    +  L  +    + 
Sbjct: 4823 SRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL--SHKEKEK 4880

Query: 4579 FSQKQDVVL--IKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4636
            F++ ++++   +++ L  +      + + L  R  +L +   + +++++ +    +WLE+
Sbjct: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940

Query: 4637 SEKSLD---SELEIANDPDKIKTQL---AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTS 4690
            +++ L    + L++ +  + +K+ +   +   +F  +L   HS+  T +     L + T 
Sbjct: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTG 4996

Query: 4691 LADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQ 4750
              D    L+  ++ L  +   +   S  + + L+        +  A + +I+ +   E +
Sbjct: 4997 KED----LEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKK 5052

Query: 4751 LAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKV 4808
            L+E   +           +  HKA    +      + AL+  A +L +   D S + +  
Sbjct: 5053 LSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSR 5112

Query: 4809 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4868
             M  +  RW  + A++  ++  LE A+ +   F++ V    E + + +  L         
Sbjct: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172

Query: 4869 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL---AICHPDSITTIKHWITIIRAR 4925
            +  L TL++ H  F+ +LE++++ L        ++L   A   P     +   IT ++ R
Sbjct: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5232

Query: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985
               +    K + + +   L      +  + ++  W+Q        + KE +     E+ A
Sbjct: 5233 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ--------ETKEYLGNPTIEIDA 5284

Query: 4986 LIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
             + E Q  + E T  + +++K+ +  K +
Sbjct: 5285 QLEELQILLTEATNHRQNIEKMAEEQKEK 5313



 Score =  281 bits (718), Expect = 2e-74
 Identities = 693/4177 (16%), Positives = 1601/4177 (38%), Gaps = 553/4177 (13%)

Query: 1112 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1169
            ++++LE+ KD L         F    +  + + +P    +L  + +  + V S S  ++ 
Sbjct: 449  IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 508

Query: 1170 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE----- 1221
            K++ + L   +L     AE+ +K +  K    E+V     N  + I   K +        
Sbjct: 509  KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 568

Query: 1222 -VDEKRQVFHALEDELQKAKAISDEMFKTYKE-RDLDFDWHKEKA--DQLVERWQ---NV 1274
             + +  +++   +  +++A+ +   M +T  + R+L  +    ++  ++++  W    N 
Sbjct: 569  ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 628

Query: 1275 HVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ 1333
               +   L D E  + +S    +D +  L  WIQQ                + ++  L Q
Sbjct: 629  VASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQ 688

Query: 1334 QKMLVSE------IEMKQ-SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKR 1386
            Q +L++       +E+KQ ++ DE  +  ++Y+    D  +    +      +   P++ 
Sbjct: 689  QLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT----DCVVTLSAFATEAHKKLSEPLEV 744

Query: 1387 RRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA 1446
              M  +  L+IQ+  D+  R    V +M    K    +   + +E  S +EE KE     
Sbjct: 745  SFM--NVKLLIQDLEDIEQR----VPVMDAQYKIITKTAHLITKE--SPQEEGKEMFATM 796

Query: 1447 KELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKM 1506
             +L++ ++ +           K  +S     S+++    E+L + + +    L K  + +
Sbjct: 797  SKLKEQLTKV-----------KECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEII 845

Query: 1507 TDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGI 1566
            T  ER      +   +    L   E+ K+       G   V++ +      ++ ++    
Sbjct: 846  TVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ---- 901

Query: 1567 CDLLTQTENRLIGHQEAFM-IGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1625
                T+ + ++     AF  +   T + KK+      L K  + S   L +V++  +  L
Sbjct: 902  ----TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGL 957

Query: 1626 KENGE-----KLSQEDKALIEQKLNEAKIK-CEQL-NLKAEQSKKELDKVVTTA------ 1672
            +E G+     +   E  + ++Q++  A +K C++L ++  EQ ++ L + V         
Sbjct: 958  EEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD 1017

Query: 1673 -----------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1721
                       +K + EK   +  +EE +T+++     +    + SE+   +H+      
Sbjct: 1018 LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP--QEGSEKIIKEHRVFFSDK 1075

Query: 1722 GTHFQEGDGKSAIGE-------EDEVNG-----NLLETDVDGQVGTTQENLNQQYQKVK- 1768
            G H         I E        D V       ++   ++   + +T   L +   K K 
Sbjct: 1076 GPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD 1135

Query: 1769 -----AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEK---------EKLQKNMKEL 1814
                 ++    IS ++  +   +   +     G+     E+         E L      L
Sbjct: 1136 YTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRL 1195

Query: 1815 KVHYETA-----------LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENL 1863
            KV  E +           LA+     K   +L  E+EK  +++ +   + +  +  LE L
Sbjct: 1196 KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1255

Query: 1864 EAGADDINGLMTKLKRQKSFSED---VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1920
             +G+ ++     K+   ++  E    ++ H+   + I+     V +      + +GG  D
Sbjct: 1256 ISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD 1315

Query: 1921 TSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1980
                H E+ RKL+   D       +       ++  + K++ +E     ++  L    ++
Sbjct: 1316 RG--HEEL-RKLESTLDGLERSRERQE---RRIQVTLRKWERFETNKETVVRYLFQTGSS 1369

Query: 1981 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL-KKTAEVLLDARGSLLPAKN 2039
              + LS       ++L  +LE+TK    +  S  V  E L K+ +E+ L  +   L    
Sbjct: 1370 HERFLS---FSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL---- 1422

Query: 2040 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN--------VE 2091
                         +  +KS+ E+ +KL+ TL   +   + +    D  G+        + 
Sbjct: 1423 ------------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWIT 1470

Query: 2092 SSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQ 2151
               KE   +  +S+A+   IS+  +  Q+I  + SSI  + E+ + F +      ++ ++
Sbjct: 1471 EKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK 1530

Query: 2152 AKMKDLSARFSEASHKHKETL--AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2209
            AK+  +  R+ E   +H + L    +  L  + +  ENL +  Q+  E + +    + + 
Sbjct: 1531 AKLTQI-RRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI- 1588

Query: 2210 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNNLSKKFK 2268
                TE  + +Q       EH    + L SL   I++    + K +  +      +   +
Sbjct: 1589 CSSATETYKVLQ-------EHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQ 1641

Query: 2269 EMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAEDLGKSL 2325
            + ED ++  KE  T+ +  L  +Q L K L S   W++    K    +    A       
Sbjct: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA------- 1694

Query: 2326 EDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNT 2385
             D  K++ +  L    IQ + N  +S  +  S +    +++ +V S              
Sbjct: 1695 -DRVKVEGELQL----IQALQNEVVSQASFYSKLLQLKESLFSVAS-------------- 1735

Query: 2386 EEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQK 2445
                    +  +K  +  +   + DL  ++  +I  L + +++ Q+  E   +   W+  
Sbjct: 1736 -----KDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1788

Query: 2446 MNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL--LEENPDT 2503
              K      QT +       +  + ++K   AE++    ++Q L+  L +L  L    D 
Sbjct: 1789 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAED- 1845

Query: 2504 PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEE---SSNNLTQFQTVEAQLKQWLVEKEL 2560
                     L  +  K ++  QL  +  Q +E    + ++L +F    A L   L  ++L
Sbjct: 1846 ---------LHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGIL--RQL 1894

Query: 2561 MVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR--------PGE 2612
              +V    S++ N  +   + +   LQ         E    +  GILS+          E
Sbjct: 1895 RQTVEATNSMNKNESDLIEKDLNDALQ----NAKALESAAVSLDGILSKAQYHLKIGSSE 1950

Query: 2613 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2672
              +      +QL    ++  +L G      D +  A++K   +Q     L   + D++ +
Sbjct: 1951 QRTSCRATADQLCGEVERIQNLLGTKQSEADAL--AVLKKA-FQDQKEELLKSIEDIEER 2007

Query: 2673 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2732
                        A+ Q+L    +++ E+   + ++   +   + ++   K+     E+ R
Sbjct: 2008 TDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ--KDVAFAPEVDR 2065

Query: 2733 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2792
            ++  +  ++ D ++     +   Q  C                +D  +E QN    +S  
Sbjct: 2066 EINRLEVTWDDTKRL----IHENQGQCC-------------GLIDLMREYQNLKSAVSKV 2108

Query: 2793 LD------VLESLIKDHKD----FSKTLTAQSHMYEKT------IAEGENL---LLKTQG 2833
            L+      V  + IKD +D    FSK  TA++ M  K        ++G++L   L K   
Sbjct: 2109 LENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHS 2168

Query: 2834 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2893
            S+ + ++  + +    W   +++++E  ++L+ SL           ++W          +
Sbjct: 2169 SDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSL-----------SIW----------D 2207

Query: 2894 EIKFCLDPAEG--ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2951
            ++    D  EG   N + ++      +D H    ELL           E + EV   +NK
Sbjct: 2208 DVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLK----------EFESEV---KNK 2254

Query: 2952 SLIQKVDMVTEQLHSKKFCLENMTQKFK---EFQEVSKESKRQLQCAKEQLDI-----HD 3003
            +L        E+LHSK   L+ +T+  +   + Q +  +  ++L+ AKE  ++      D
Sbjct: 2255 AL------RLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKD 2308

Query: 3004 SLGSQAYSNKYLTMLQT-------------QQKSLQALKHQVDLAKRLAQDLVVEASDSK 3050
                     K++  + T             Q ++ +ALK   D+ K L       +S  +
Sbjct: 2309 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQE 2368

Query: 3051 GTSDVLLQVET------------IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMF 3098
              + +  +  +            + ++H  +SQ   +  + L+  L+   HF  +++E  
Sbjct: 2369 NLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQ 2426

Query: 3099 SQF-------AEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDN--ANKTC 3149
              F        E  D       +      LQ   +++     KL+A+        A+ + 
Sbjct: 2427 EWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSK 2486

Query: 3150 KMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI 3209
            +++ + +E    +     + +A  KQC K        ++ ++     L  F  + ++ ++
Sbjct: 2487 QIVSSIQE---QITKANEEFQAFLKQCLK-------DKQALQDCASELGSFEDQHRKLNL 2536

Query: 3210 LLQKAEE--HEESQGPVGMETETINQQLNMFKVF------QKEEIEPLQGKQQDVNWLGQ 3261
             + + EE  + E+ G           +++  ++F       +E ++ L  + Q ++  G 
Sbjct: 2537 WIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGH 2596

Query: 3262 GLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSW 3321
            G  Q     +       +L     R      +  Q A Q  EAL      ++AL+S+  W
Sbjct: 2597 GAGQEGRLCSQLLTSHQNL----LRMTKEKLRSCQVALQEHEAL------EEALQSMWFW 2646

Query: 3322 MVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381
            +   ++ +A  +        ++ ++ + + +  +  + +  + +   +GE+   ++    
Sbjct: 2647 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2706

Query: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441
            +  I  QL  L   W  +++ +      LE +      + E    L +W+ ++++++ + 
Sbjct: 2707 QRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEH- 2765

Query: 3442 EPIGTQASKLEEQIA--QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLD 3499
             P+  Q    E+ +     +++  +  +H + LH+   I +S ++    ED+    +  +
Sbjct: 2766 -PLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRL--IAKSRELYEKTEDESFKDTAQE 2822

Query: 3500 FSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559
              +  + +I   +  +   +++ + +  ++ +   E  +WL+   ++L + S     +  
Sbjct: 2823 ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSA 2882

Query: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKD--- 3616
              K+ S+++ L +   +    + +      E+ + TT     ++  +++A++A +K    
Sbjct: 2883 TQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWED 2942

Query: 3617 ------------ITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVE-VELLSYETQV 3663
                        +++++    +   Q  QL + L      L TW  ++  +E  + + ++
Sbjct: 2943 SVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEI 3002

Query: 3664 L----KGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED 3719
            +    KG+E   A      L+K     + L   LNE+     +L  +  +  +  ++ E 
Sbjct: 3003 VECWHKGQEILDA------LQKAEPRTEDLKSQLNELCRFSRDLSTYSGK--VSGLIKEY 3054

Query: 3720 NERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTS 3779
            N      S     K +      +  Q+F +A      W+   +       DI     + S
Sbjct: 3055 NCLCLQASKGCQNKEQ------ILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVS 3108

Query: 3780 AQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQIN 3839
              LQ  + F  E    +  ++ ++  G  + T  ++E+ + ++ K+    +++       
Sbjct: 3109 TSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNL 3168

Query: 3840 SERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRE 3899
             ++   LE  +  +  F  + E +  WL++T+ ++ +      +    R++Q++ + + E
Sbjct: 3169 HQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLE 3228

Query: 3900 LIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAIS 3959
             I  ++P ++++ +   QL E       S + +     + Y  +    K++   LD  ++
Sbjct: 3229 EIHCYEPQLNRLKEKAQQLWE-GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVA 3287

Query: 3960 QSTQF-------HDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKL 4012
            +  QF        D +   +  L+           + +   K++  +S  +   + M   
Sbjct: 3288 EHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQM--- 3344

Query: 4013 QPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI-------HTLVEEREA 4065
                + +  RGE ++  +           +Q +L  +  +W ++        + +E   +
Sbjct: 3345 ----KMIVTRGESVLQNTSPE----GIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3396

Query: 4066 KLLDVMELAEKF--WCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEID 4123
            K     +   +F  W D M     + +++    +L D              A+ + EE+ 
Sbjct: 3397 KWTSYQDGVRQFSGWMDSME--ANLNESERQHAELRDK-------TTMLGKAKLLNEEVL 3447

Query: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAA 4183
                 L+ +       +   G  +  + +  + +L   + ++ +  K+ + K E+ ++  
Sbjct: 3448 SYSSLLETI------EVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLH 3501

Query: 4184 VQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNH 4243
             +YQ  L+A   W+     KL   S +  D  T +  + +L++ +    + Q  +  + H
Sbjct: 3502 QEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLH 3561

Query: 4244 QAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDEL 4303
              E ++     +++   ++     L+  W + + R+   + +    +  L   +    ++
Sbjct: 3562 TREDVIPSGIPQAEDRALE----SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQV 3617

Query: 4304 LAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4363
              WL                      + A+      +V A++  VE V     ++++ S 
Sbjct: 3618 DEWL----------------------KTAEEKKWHEEVTAYRDEVEEVGARAQEILDES- 3654

Query: 4364 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4423
                S +  +   L  R+Q +L +  ++ + L+  ++  +     +     W   T ++ 
Sbjct: 3655 -HVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNF 3713

Query: 4424 --LASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQ 4481
              +A+K          ++L     +    E      KS  +KG++ +    +     + +
Sbjct: 3714 KNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRK 3773

Query: 4482 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4541
            +I++  E+ + + + + +    LE+ L+LA EF +  +    W+ + ++ L+V   P + 
Sbjct: 3774 EIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKME 3833

Query: 4542 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL--------------KYFSQKQDVVL 4587
            L     Q+ ++K     V SH   +  + + G  L              +  S  QD+  
Sbjct: 3834 LYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCS 3893

Query: 4588 IKNLLISVQSRWEKVVQRLVERGRSL-----DDARKRAKQ--------FHEAWSKLMEWL 4634
            I   ++   + +E  +  L  +G +L     D  + + KQ          +++S +    
Sbjct: 3894 IGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTA 3953

Query: 4635 EESEKSLDSELE-IANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693
            +   +SL+ EL+   +  D ++   A     Q  L        +     + +K   +L +
Sbjct: 3954 QRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE 4013

Query: 4694 DNLKLDDMLSELRD----KWDTICGKSVERQNKLEEALLFSGQFTDALQALID-----WL 4744
                  D+L  + D       T      + +  +E+ L+ +   T   + +       W+
Sbjct: 4014 QARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWI 4073

Query: 4745 Y--RVEPQLAEDQPVHGDIDL--VMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR 4800
            Y    + QL   +  H +++L    N++   K F K+L  + +SV  +     +L   ++
Sbjct: 4074 YLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKL---TK 4130

Query: 4801 DDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR 4860
             + S    ++  L+ +W  +C  S +   + E  L++  ++H  ++ +  +L +   T  
Sbjct: 4131 KEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKF--TTE 4188

Query: 4861 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWIT 4920
            +  +   D ++    ++  K+    L+E++  +         ++   + D    +K   +
Sbjct: 4189 WDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTS 4248

Query: 4921 IIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI 4980
             +  R+ ++    K+  Q   + L  L   Q   + L+ W +  +  + +  K+  P ++
Sbjct: 4249 HLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDM 4308

Query: 4981 EEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAAD 5017
               + L+ +H     E+  KQ  +  + K   R  AD
Sbjct: 4309 --AQNLLMDHLAICSELEAKQMLLKSLIKDADRVMAD 4343



 Score =  271 bits (694), Expect = 1e-71
 Identities = 876/4843 (18%), Positives = 1865/4843 (38%), Gaps = 750/4843 (15%)

Query: 683  QYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 742
            Q A+ ++   N  R  + L  F S   N+ + L E   +    D  E   N+    D   
Sbjct: 2226 QMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSK--VNDLKELTKNLETPPDLQF 2283

Query: 743  ELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ-LCQCVEQHI 801
             +  +L QK E+ K + E+A+  L +       +E +   + T ++ + + L  C +   
Sbjct: 2284 -IEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ--- 2339

Query: 802  KENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYK 861
                      N+  EA   +++++  +Q + S + SS+   L  L ++          Y 
Sbjct: 2340 ----------NETCEALKKVKDIQKELQSQQS-NISSTQENLNSLCRK----------YH 2378

Query: 862  STIANLMGKAKT-IIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRA 920
            S     +G+A T +I+     S    KT   ++   + +    ++ +  E  L   +  A
Sbjct: 2379 SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE-KHFSESMQEFQEWFLGAKA--A 2435

Query: 921  KWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWH 980
              +    TG+  ++ +    +        D  ++++   Q   TL+  +H++ + V S  
Sbjct: 2436 AKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY--AHLSKQIVSS-- 2491

Query: 981  YLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVF----------- 1029
             +  +I +      A +K  L  + +Q L +  S    F +  ++  ++           
Sbjct: 2492 -IQEQITKANEEFQAFLKQCL--KDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTE 2548

Query: 1030 ----SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDR 1085
                S   I + + EV+  + +  ELL + E  ++      L   E           E R
Sbjct: 2549 NLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGA-----GQEGR 2603

Query: 1086 LIRQIRTPLERDDLHESVFRITEQEKLK------KELERLKDDLGTITNKCEEFFSQAAA 1139
            L  Q+ T       H+++ R+T+ EKL+      +E E L++ L ++    +    + A 
Sbjct: 2604 LCSQLLTS------HQNLLRMTK-EKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLAC 2656

Query: 1140 SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVK----LYETKL 1195
            + S    +  L   L  +  +  M      KL     + K  QA  +  K    + +T+L
Sbjct: 2657 AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMA--IGKGEQALRSSNKEGQRVIQTQL 2714

Query: 1196 CEEEAVIAD--------KNNIENLIST----------LKQWRSEVDEKRQVFHALE---- 1233
               + V AD        ++ +E++IS           L+QW   VD+K  + H L+    
Sbjct: 2715 ETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK--IEHPLQPQPG 2772

Query: 1234 --------DELQKAKAISDEMFKTY-----KERDL-----DFDWHKEKADQLVERWQNVH 1275
                    D LQ   + +++  +       K R+L     D  +     ++L  ++ ++ 
Sbjct: 2773 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIM 2832

Query: 1276 VQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKT------LAT 1329
                 ++R +E I K    Y D  H   DW+   +    +  +   ++S T      +  
Sbjct: 2833 TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKE 2892

Query: 1330 QLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMT--YRAMVDSQQKSPVKRR 1387
             ++ +++  S +   +S   E ++        +   E+Q +   ++   DS  ++     
Sbjct: 2893 LIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLE 2952

Query: 1388 RMQSSADLIIQEFM-------DLRTRYTALVTLMTQYIKFAG------------------ 1422
             + S   L  QEF            +++AL+    Q +                      
Sbjct: 2953 NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEI 3012

Query: 1423 -DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAE----KAGKPPFSKQKIS 1477
             D+L++ E   + L+ +  E    +++L  +   +S  +K+      +A K   +K++I 
Sbjct: 3013 LDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072

Query: 1478 SE----------------EISTKK--------EQLSEALQTIQLFLAKHGDK-------- 1505
             +                +I+T K         ++S +LQ IQ FL++  +         
Sbjct: 3073 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMML 3132

Query: 1506 ---------MTDEERNELEKQVKTLQESYNLLFS---------ESLK-QLQESQTSGD-- 1544
                     +T E+   ++ +V   +E +    S         E+LK Q+++ + S +  
Sbjct: 3133 SKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPI 3192

Query: 1545 ---VKVEEKIVAER---------QQEYKEKLQGICDLLTQTE---NRLIGHQEAFMIGDG 1589
               +   EK+V E          ++  ++KLQ + + +   E   NRL   ++A  + +G
Sbjct: 3193 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL--KEKAQQLWEG 3250

Query: 1590 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN-----GEKLSQE--------- 1635
                K ++ +  +L       +    E V   +  + E+     G K  Q+         
Sbjct: 3251 QAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHML 3310

Query: 1636 --------DKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVA--AVKQ 1685
                    DK++++ +     +K E L L  +Q K+   K++ T  +   +  +   +  
Sbjct: 3311 DSYCHPTSDKSVLDSRT----LKLEAL-LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT 3365

Query: 1686 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIE---QNGTHFQEGDGKSAIGEEDEVNG 1742
            +++    ++++  W S +      AG + K  +E      T +Q+G  + + G  D +  
Sbjct: 3366 IQQQLQSVKDM--WASLLS-----AGIRCKSQLEGALSKWTSYQDGVRQFS-GWMDSMEA 3417

Query: 1743 NLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE 1802
            NL E++   +      +      K K  +E+++S    +         + E    Y++  
Sbjct: 3418 NLNESE---RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE---HYVTQL 3471

Query: 1803 EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELEN 1862
            E + LQ+  + ++   + A+ +SEK ++L    Q +L+ F+        WL Q +++L+ 
Sbjct: 3472 ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEV-------WLGQEQEKLDQ 3524

Query: 1863 ---LEAGAD-------DINGLMTKLKRQKSFSEDVISHKGDL--RYITISGNRVLEAAKS 1910
               LE  A        D+  L       ++    V+  + D+    I  + +R LE+ + 
Sbjct: 3525 YSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQ 3584

Query: 1911 CSKRDGGKVDTSA-THR--EVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDAS 1967
                     D  A  HR  E + + ++  ++ R +  K   +   LK   +K  H E  +
Sbjct: 3585 ---------DWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTA 3635

Query: 1968 CG---LLAGLQACEATASKHLSEPIAVDPKNLQRQ--------LEETKALQGQISSQQ-- 2014
                    G +A E     H++  +      L  +        LE+ K L+ +I S +  
Sbjct: 3636 YRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEES 3695

Query: 2015 ------------------------------VAVEKLKKTAEVLL---DARGSLLPAKND- 2040
                                          V + K  KT EVLL   +   SLL +  + 
Sbjct: 3696 ESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREK 3755

Query: 2041 ---------------IQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLD 2085
                           ++K + D + + ++L+ +V + +  L+  L  +    D    +  
Sbjct: 3756 GERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQ 3815

Query: 2086 WMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS 2145
            W+   +  L    +  +     +  +SK   L+Q +   + S+ ++ EK +  +E     
Sbjct: 3816 WIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV 3875

Query: 2146 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTF-------LET 2198
            T   L+ K+  L + + +     K   A MEE+    +   NL  K  T        L+ 
Sbjct: 3876 T---LKDKIDQLQSDYQDLCSIGK---AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA 3929

Query: 2199 KTQALTEVDVPG-KD----VTELSQYMQESTSEFLEHK--KH------LEVLHSLLKEIS 2245
            K +      + G KD    +   +Q M +S    LEH+  KH      L+   + L  + 
Sbjct: 3930 KLKQNVHAHLQGTKDSYSAICSTAQRMYQS----LEHELQKHVSRQDTLQQCQAWLSAVQ 3985

Query: 2246 SHGLPSDKA-LVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKE 2304
                PS +  L   +     K F+ +++  +   + + S     D     VK+    I++
Sbjct: 3986 PDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCS---MCDLSNASVKTTAKDIQQ 4042

Query: 2305 TTKKVPIVQPSFGAEDLGKSLEDTKKLQ-EKWSLKTPEIQKVNN-----SGISLC---NL 2355
            T + +   Q    A++L +  E+ K L+ E W       Q++ N     S + L    N+
Sbjct: 4043 TEQTIE--QKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNM 4100

Query: 2356 ISAVTTPAKAIAAVKSG-GAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLL 2414
            +S V    K + + ++    ++      T  EE   +K +  +     D+     +L L 
Sbjct: 4101 VSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQ 4160

Query: 2415 LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKS 2474
             ++           LQ+ ++    M      + K  T+W    A +D E+    +E  K 
Sbjct: 4161 REED----------LQRTRDYHDCMNVVEVFLEKFTTEWDNL-ARSDAESTAVHLEALKK 4209

Query: 2475 FEAELKQNVNKVQELKDKLTELLEE-NPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2533
                L++    +++LKD+  +++E  N D  E    K+  + ++ +W +L  L    ++K
Sbjct: 4210 LALALQERKYAIEDLKDQKQKMIEHLNLDDKELV--KEQTSHLEQRWFQLEDLI---KRK 4264

Query: 2534 LEESSNNLTQFQTVEA---QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFA 2590
            ++ S  NL +   V++   +L +W  E++  ++     S  P+M          +  E  
Sbjct: 4265 IQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELE 4324

Query: 2591 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2650
             ++   + L      +++  G +   R ++++ L+      + L+  +  R  ++++A+ 
Sbjct: 4325 AKQMLLKSLIKDADRVMADLGLNE--RQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4382

Query: 2651 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2710
            + TQ+   +   + ++   + K+     +   PD +++Q++T +  +  ++  + ++   
Sbjct: 4383 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4442

Query: 2711 QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSR 2770
             A   +L   V E+  K+E+  +L+ +   +  V QK  + +Q L+    S   F++   
Sbjct: 4443 WAQGRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKE--- 4498

Query: 2771 DFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK--TLTAQSHMYEKTI----AEG 2824
            DF       K+    + P   +++++    + H   +K   +  QS  YE  +      G
Sbjct: 4499 DFDKACHWLKQADIVTFP---EINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTG 4555

Query: 2825 ENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPW 2884
            + +L      + + L  +LN +   ++      K++  K++E++    +Y   +E     
Sbjct: 4556 QTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQS 4615

Query: 2885 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKE 2944
            + + +     +         E +++     +  +D+  G+ E ++             + 
Sbjct: 4616 LSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQP 4675

Query: 2945 VVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLD--IH 3002
               D+   L+     +  Q   +   LE+ T  ++E +++ ++ +RQL+  KE+      
Sbjct: 4676 WQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE 4735

Query: 3003 DSLGSQAYSNKYLTMLQTQQKSLQALK----HQVDLAKRLAQDLVVEASDSKGTSDVLLQ 3058
            ++L ++     Y ++  + Q S   LK    H  DLA  L         D         Q
Sbjct: 4736 ETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHL---------DPLAYEKARHQ 4786

Query: 3059 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELD-------SM 3111
            +++   E   L+  + E  +  E+++     FQ  +            EL        ++
Sbjct: 4787 IQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNL 4846

Query: 3112 APVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEA 3171
              +  +   +Q  +E +++ L+ + AL  S+    K  K   A E  S DL   +  L  
Sbjct: 4847 QDIQEEIRKIQIHQEEVQSSLRIMNAL--SHKEKEKFTK---AKELISADL---EHSLAE 4898

Query: 3172 LSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETI 3231
            LS+    + +  + R+  +     + + +Y   +  +  L+ A+E  +  G  G++ E+ 
Sbjct: 4899 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN-GLDVESA 4957

Query: 3232 NQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLN 3291
             + L     F   E +      ++++ L    +    K T  + LE  +  +  R + ++
Sbjct: 4958 EENLKSHMEFFSTE-DQFHSNLEELHSL-VATLDPLIKPTGKEDLEQKVASLELRSQRMS 5015

Query: 3292 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKA------- 3344
            +    +   LQ        +Q A E ++  M DTE+ +       +EF ++K        
Sbjct: 5016 RDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKL-------SEFSLLKTSSSHEAE 5068

Query: 3345 -QIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKA 3403
             ++ E K L  +++     +  ++ +  ++  T   A K  + + ++ +  RW  L   A
Sbjct: 5069 EKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVA 5128

Query: 3404 ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALED 3463
            + + + LE        F+  ++   E +  ++ +L          ++L   +  H     
Sbjct: 5129 QDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5188

Query: 3464 DIINHNKHL----HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELL 3519
            ++      L     Q +S+ Q     +  E+  ++Q ++   Q   + +QEK  +  +L+
Sbjct: 5189 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ-EITAMQDRCLNMQEKVKTNGKLV 5247

Query: 3520 QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQ 3579
            +Q L + ++       +  W+ E  + L   +++      +  Q  EL++L  +    +Q
Sbjct: 5248 KQELKDREMVETQINSVKCWVQETKEYLGNPTIE------IDAQLEELQILLTEATNHRQ 5301

Query: 3580 NVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLH 3639
            N+++      E  K+       I+  +L    A       L   +   ++  ++   +  
Sbjct: 5302 NIEKM----AEEQKEKYLGLYTILPSELSLQLAE----VALDLKIRDQIQDKIKEVEQSK 5353

Query: 3640 STHEELCTWLDKVEVELLSYETQV-LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3698
            +T +EL   + K+  +L +  T++  K +   QA+   K L +E     + L  L+    
Sbjct: 5354 ATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ 5413

Query: 3699 ALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWI 3758
              LE    +  + L K + +  E ++        ++ +++ A    +++++  +  L WI
Sbjct: 5414 KFLE-QNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI 5472

Query: 3759 TETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRH-KDIIDDLVKSGHKIMTACSEEE 3817
             +   K+++ G I      +++QL+ Q      +L   K+I  +L     K+    S   
Sbjct: 5473 EKA--KVLAHGTIAW---NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYC 5527

Query: 3818 KQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQL 3877
             + M +++ ++ +  + + Q+   R   L+ A   + +F    ++L   L + Q   + L
Sbjct: 5528 TEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ---ATL 5584

Query: 3878 PAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAAD 3937
             +P +   +L++Q    + L   +   KP +  +     QL +        I E  VA+ 
Sbjct: 5585 TSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV-----QLCQ----SALRIPEDVVASL 5635

Query: 3938 TL----------YSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPS 3987
             L           S+++    ++   +  A+ Q  Q+  ++  + + +E     +   P 
Sbjct: 5636 PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPV 5695

Query: 3988 ISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLD 4047
             ++ +++++ QIS ++ ++  ++  Q           E IA      K ++ KA    + 
Sbjct: 5696 ATSNIQELQAQISRHEELAQKIKGYQ-----------EQIASLNSKCKMLTMKAKHATML 5744

Query: 4048 QMVFIWENIHTLVEEREAKLLD--------VMELAEKFWCDHMSLIVTIKDTQDFIR-DL 4098
              V   E +    E+ + +LL         VM  A +  C  +   VT +  ++    ++
Sbjct: 5745 LTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGR--CHTLLSPVTEESGEEGTNSEI 5802

Query: 4099 EDPGI--DPSVVKQ-----QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPD-KPI 4150
              P     PS V        Q+ A       + LQ +    I+  +       EP  +P 
Sbjct: 5803 SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDA-AKIHPSTSASQEFYEPGLEPS 5861

Query: 4151 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4210
                + +L  +W++L     ++   L EA++   +YQD LQ++   ++    KL+     
Sbjct: 5862 ATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP 5921

Query: 4211 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTE--ESDKHTVQDPLME 4267
            G   E+   Q+ E +    E    Q E+  L    AE L+ +  E   +++  +Q  L  
Sbjct: 5922 GRSPES---QMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTV 5978

Query: 4268 LKLIWDSLEERIINRQHKLEGAL----------LALGQFQHALDELLAWLTHTEGLLSEQ 4317
            L     ++  +   ++  LE  L           AL +++   DEL +WL  T+  L   
Sbjct: 5979 LAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTA 6038

Query: 4318 KPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAG----NDLIESSA--GEEASNLQ 4371
                 +P  +E +L      QN ++  +  V A+++      N L+E  A   +EA  L 
Sbjct: 6039 LSPPKEPMDMEAQLMD---CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLA 6095

Query: 4372 NKLEVLN------QR----WQNVLEKTEQRK---------------------------QQ 4394
             KL  L       QR     Q  ++ T Q K                           QQ
Sbjct: 6096 GKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQ 6155

Query: 4395 LDGALRQAKGFHGEIEDLQQWLTDT---------------------ERHLLASKPLG--G 4431
               +L+Q K    E+ + +  L                        E+  + S+ LG  G
Sbjct: 6156 RQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEG 6215

Query: 4432 LPETAKEQLNVHME-VCAAFEAKEETYKSLMQKGQQ---------MLARCP--------- 4472
               +A++Q+ +  E +   F  K++  ++++++ Q+         +L+  P         
Sbjct: 6216 EKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQ 6275

Query: 4473 -KSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQT 4531
             KSA T++   ++ L + +E V ++    K    ++++L  + ++ +     WL   E+ 
Sbjct: 6276 DKSAVTSL---LDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEER 6329

Query: 4532 LNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ-------KQD 4584
            L VA+  +L+ +     +   ++ A ++   +E   E+DK   +   FSQ        +D
Sbjct: 6330 LFVAT--ALLPEETETCLFNQEILAKDI---KEMSEEMDK---NKNLFSQAFPENGDNRD 6381

Query: 4585 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4644
            V  I++ L  +  R   +   + +R   + +  ++   F      L   L +++  +  +
Sbjct: 6382 V--IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6439

Query: 4645 L------EIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL 4698
            L       +A   + I+      KEF         + +   R  +   E+ S+ +     
Sbjct: 6440 LANVFEQPVAEQIEAIQQAEDGLKEFDA------GIIELKRRGDKLQVEQPSMQE----- 6488

Query: 4699 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQP-V 4757
               LS+L+D +D +      R++ L + L    Q+  ALQ L D L   + ++A DQ  +
Sbjct: 6489 ---LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6545

Query: 4758 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4817
                + +  L+D HK + + L       + L    R++I  +    +       EL  + 
Sbjct: 6546 VSSKEEIQQLLDKHKEYFQGLESHMILTETL---FRKIISFAVQKETQFHT---ELMAQA 6599

Query: 4818 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4877
              V   +  +   LE  L            L   L   E ++   G++ ++ED L   I 
Sbjct: 6600 SAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT 6659

Query: 4878 QHKEFMKKLEEKRAELNKATTMGDTVL-AICHPDSITTIKH----WITIIRARFEEVLAW 4932
             ++     L E + +L +    G  +L +I   D  + +      W++      +E+   
Sbjct: 6660 LYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKEL--- 6716

Query: 4933 AKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT--DKDKEVIPQEIEEVKALIAEH 4990
                  RL + L      Q     L+ WLQ A+  L    +    +PQE+E V+  +   
Sbjct: 6717 -----HRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAF 6771

Query: 4991 QTFMEEMTRKQPDVDKVTKT----YKRRAADPSSLQSHIPVLD 5029
              F +E+  +      V  T     + +  D ++L+S +  +D
Sbjct: 6772 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRID 6814



 Score =  270 bits (691), Expect = 2e-71
 Identities = 771/4190 (18%), Positives = 1619/4190 (38%), Gaps = 553/4190 (13%)

Query: 631  LPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLT-YAEKLHRLESQYAKL 687
            L    S  + H+ + + +E    S+KE  +K++E  + A  KL  Y      L+     L
Sbjct: 4702 LEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVL 4761

Query: 688  LNTSRNQER---HLDTLHNFVSRATNEL-IWLNEKE--EEEVAYDWSERNTNIARKKDYH 741
               + + E    HLD L     +A +++  W  E +     +    +E  + + +  D+ 
Sbjct: 4762 KRVTIHLEDLAPHLDPLA--YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819

Query: 742  AELMRELDQKEE-------------NIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWS 788
             E+ R LD                 N++ +QE   ++ +     + ++    A    +  
Sbjct: 4820 TEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE 4879

Query: 789  WILQLCQCVEQHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYS-CDRSSSIHKLEDL 846
               +  + +   ++ + A   E   D +EA   LR  +  +   YS C R    +++   
Sbjct: 4880 KFTKAKELISADLEHSLAELSELDGDIQEA---LRTRQATLTEIYSQCQR---YYQVFQA 4933

Query: 847  VQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIY 906
              + +E+ +ELLQ       L G       L   +++  LK+ +   +  D  Q    + 
Sbjct: 4934 ANDWLEDAQELLQ-------LAGNG-----LDVESAEENLKSHMEFFSTED--QFHSNLE 4979

Query: 907  KDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW 966
            +    V   +       +I PTG E +   V        + + D   +++   Q     W
Sbjct: 4980 ELHSLVATLDP------LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDL-LQRCTAQW 5032

Query: 967  HESHINMKSVVSWHYLINEIDRIRASNVASIKTMLP-------GEHQQVLSNLQSRFEDF 1019
            H+     + V+    L+N+ ++ + S  + +KT           EH+ ++S + S  E  
Sbjct: 5033 HDYQKAREEVIE---LMNDTEK-KLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKI 5088

Query: 1020 --LEDSQESQVFSGSDITQ--LEKEVNVCKQYYQELLKSAEREEQ--EESV--YNLYISE 1071
              LE+       +G+D ++  L + +    Q +  L   A+ +E+  E++V  +  + ++
Sbjct: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148

Query: 1072 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 1131
            V+     ++  +D+L     +  E+    E +  +   +    ELE+ +  LG +  +  
Sbjct: 5149 VKKATEMIDQLQDKLPG---SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTL 5205

Query: 1132 EFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 1189
                  AA +    P L  E+  +    ++  +M        K V   LK+ +  E  + 
Sbjct: 5206 SMLQDGAAPTPGEEPPLMQEITAM---QDRCLNMQEKVKTNGKLVKQELKDREMVETQIN 5262

Query: 1190 LYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS----- 1243
              +  + E +  + +    I+  +  L+   +E    RQ    + +E QK K +      
Sbjct: 5263 SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEE-QKEKYLGLYTIL 5321

Query: 1244 -DEMFKTYKERDLDFDWHKEKADQLVE------RWQNVHVQIDNRLRDLEGIGKSLKYYR 1296
              E+     E  LD     +  D++ E        Q +  QI    +DL  I   LK   
Sbjct: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5381

Query: 1297 DTYHPLDDWIQQVETTQRKIQENQPE-NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1355
            D        + Q +T Q+ + E     NSK +      QK L    ++ +    +  K  
Sbjct: 5382 DN-------VVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLT 5434

Query: 1356 EQYSATVKDYELQTMT----------YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1405
            E +  T++  E +             Y  M++   K  +++ ++ +   +       LR 
Sbjct: 5435 ELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW-IEKAKVLAHGTIAWNSASQLRE 5493

Query: 1406 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1465
            +Y    TL+               EE K ++ E +   EK + L         + + AE 
Sbjct: 5494 QYILHQTLL---------------EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAEL 5538

Query: 1466 AGKPPFSKQKI-----SSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1520
              +    +Q I     + ++ +   ++    L+ +Q  L +    +T  E   L  + + 
Sbjct: 5539 GRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQL 5598

Query: 1521 LQESYNLLFSESLK-QLQESQT-SGDVKVEEKIVAERQQEYKEKLQGICD--LLTQTENR 1576
                + L   ESLK ++Q  Q     +++ E +VA            +C   L  Q E  
Sbjct: 5599 SHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP---------LCHAALRLQEEAS 5649

Query: 1577 LIGH---QEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLK-----EN 1628
             + H   Q+  ++    V+ ++Y+ + + LQ+ ++G+ + + +    T N  +       
Sbjct: 5650 RLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISR 5709

Query: 1629 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1688
             E+L+Q+ K   EQ +     KC+ L +KA+ +   L       + E TE +        
Sbjct: 5710 HEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768

Query: 1689 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1748
            S           S V   + R  T    V E++G   +EG   S I              
Sbjct: 5769 SAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGTN-SEISSPPACRS------ 5810

Query: 1749 VDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKE 1805
                V  T  ++NQ    YQ + A  E++ +    +  +T ++Q   E   +  +  +  
Sbjct: 5811 -PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLG 5867

Query: 1806 KLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE 1857
             LQ++ + LK          YE AL   +K      S+  ++E  +   +E     +  E
Sbjct: 5868 DLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5926

Query: 1858 QELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDG 1916
             ++   +A  D+I  L  ++   Q S +E+++S                   +SC     
Sbjct: 5927 SQMAEHQALMDEILMLQDEINELQSSLAEELVS-------------------ESCEADPA 5967

Query: 1917 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY------QHYEDASCGL 1970
             ++   +T   +  ++  +T R ++   K  +L   L D +++       Q Y   +  L
Sbjct: 5968 EQLALQSTLTVLAERM--STIRMKAS-GKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL 6024

Query: 1971 LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAE-VLLD 2029
             + L + +AT    LS P   +P +++ QL + + +  +I  + VA+ +L    E +LL+
Sbjct: 6025 DSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082

Query: 2030 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------------ITLTRSLSVQ 2077
             +         +   L  + G   +L ++++++   +Q            +T T+S  VQ
Sbjct: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ 6142

Query: 2078 DGLDEM-LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2136
            + L +    W    +SSL++Q +       L+  +++   L + +A R   I   +   +
Sbjct: 6143 EWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSVASRGEEILIQHSAAE 6195

Query: 2137 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL--SEKLQT 2194
               +  +     S +  M+   +   +      E+L   +E  TK +L +N+   E+ Q 
Sbjct: 6196 TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH--QEFSTKQKLLQNVLEQEQEQV 6253

Query: 2195 FLETKTQALTEV-----DVPGKDVTE-------LSQYMQESTSEFLEHKKHLEVLHSLLK 2242
                  + L+ V     DVP +D +        L+Q  +E +S+    K+    L   L 
Sbjct: 6254 LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY 6313

Query: 2243 E-----------------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC- 2284
            +                 +++  LP +    L     L+K  KEM + + + K   +   
Sbjct: 6314 DGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAF 6373

Query: 2285 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2344
             E  D   V+  +L   +   +    +V        + + L+     Q    LK      
Sbjct: 6374 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQILNFQN--DLKVLFTSL 6429

Query: 2345 VNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNGEGTATNTEEFWANKG 2393
             +N  I L  L +    P A+ I A++          +G   L   G     E+      
Sbjct: 6430 ADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ------ 6483

Query: 2394 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2453
                 ++++ +   Y++L +++  + + LN  L+ L+   E +   +  L +  +     
Sbjct: 6484 --PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQDLADLLETGQEKMAG 6540

Query: 2454 QQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQML 2513
             Q    +  E ++  ++++K +   L+ ++   + L  K+     +           Q  
Sbjct: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET--------QFH 6592

Query: 2514 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2573
            TE+ ++   + +    R  +LE      +     + +L + L   E  +  +G +  + +
Sbjct: 6593 TELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENED 6652

Query: 2574 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLRGIVKEQLAAVTQKWD 2632
             L  +    Q L       +P+  Q+   G+ +L S    D      ++ QL  + + W 
Sbjct: 6653 RLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD------LESQLNQLGECWL 6706

Query: 2633 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS----SSLAVSTHPDAMNQ 2688
            S T ++S     ++  +   T+YQS    L   L    ++L      S+ V    + +  
Sbjct: 6707 SNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRD 6766

Query: 2689 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSR---QLEGILKSFKD 2743
             L    +  +E+  +        +    L  L K +   L++ELSR   Q   +L +   
Sbjct: 6767 HLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPA 6826

Query: 2744 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT-----KKEEQNKSHPISAKLDVLES 2798
            V++K     Q       S H   ++     +W+       +K+E N  + I  K   +  
Sbjct: 6827 VQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDEDNIKNSIGYK--AIHE 6877

Query: 2799 LIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2855
             ++ +K F   +  +        +++ +  +  ++++ S+K     QL  +  +W     
Sbjct: 6878 YLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQG 6937

Query: 2856 QVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQ 2915
             V E+   L+  LE   +Y+  V+ L  W +  +  L++     D A  +N++   + L+
Sbjct: 6938 LVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE 6997

Query: 2916 KEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCLENM 2974
                               L+   E + E +     +LIQ K + V+  + S    L  +
Sbjct: 6998 ------------------DLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST---LREL 7036

Query: 2975 TQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY-LTMLQTQQKSLQALK 3029
             Q +     +  + K  L+   +Q   H    D + S     +Y L+  +    SL+A++
Sbjct: 7037 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7096

Query: 3030 HQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC-----SFLETKL 3084
             QVD  + L  DL  +              E   Q+  +++ Q+ ++C       L   L
Sbjct: 7097 VQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLLKECHPPVTETLTNTL 7142

Query: 3085 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQKETIKAFLKKLEALM 3139
            + +    N + E  ++  +    L  +    +D     A T+Q+Q++     LK      
Sbjct: 7143 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 7202

Query: 3140 ASNDNAN---KTCKMMLATEETSPDLV--------------------GIKRDLEALSKQC 3176
             ++D      + C  +L    T  D +                     I+ D  +LS+  
Sbjct: 7203 IADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 7262

Query: 3177 NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV-GMETETINQQL 3235
              L      ++  ++  +   E F   L+     + +AEE  + Q P    +  TI +++
Sbjct: 7263 CALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7322

Query: 3236 NMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA 3295
               K  Q  +   +      +N LG  L  +  +    Q L       N  W  ++ +  
Sbjct: 7323 EELKG-QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL-------NRHWSLISSQTT 7374

Query: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
            +R ++LQ  LL    F +  E+ + ++V TE+ +A +   S  ++ +  Q +  +L Q  
Sbjct: 7375 ERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRAHELFQAE 7432

Query: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV 3415
            +  R+  +  I  +G+++    +  D+ +   +L+LL ++W+ ++ +A+ R   ++    
Sbjct: 7433 MFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR 7492

Query: 3416 VAQQFHETLEPLNEWLTTIEKRLVN---CEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3472
              Q++ E  E L +WL  +    ++     PI  Q ++      Q K  E   +      
Sbjct: 7493 QWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVFLRQQGSY 7550

Query: 3473 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
               V  G+ L + +    +  +Q++L        EIQEK  S S  L++         +D
Sbjct: 7551 ILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASMRLEEQKKKLAFLLKD 7603

Query: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQAL------L 3586
              +    + +  +KL     +   ++ L     EL   Q    +R + ++ A+      L
Sbjct: 7604 WEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQ----MRCKELENAVGSWTDDL 7657

Query: 3587 NGLELLKQT-----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3641
              L LLK T     + D++ I+ +++E ++ +++++    +   + + + L         
Sbjct: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717

Query: 3642 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALL 3701
            ++ELC WL ++E ++ S    +L  E   + +   +E    A+ NK  L  + E    L 
Sbjct: 7718 NKELCEWLTQMESKV-SQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGE---RLA 7773

Query: 3702 ELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITET 3761
            +         +E  + + N+R++ + D I  +V+++   ++  QQ D+   +  +W+   
Sbjct: 7774 KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHI 7833

Query: 3762 EKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC----SEE 3816
            E +L   +       ++   +L  Q+    +I +H   +  ++     ++  C    ++ 
Sbjct: 7834 ESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 7893

Query: 3817 EKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQ 3876
            E  S+++    + + +  IC ++ ER L++E    L  +F + Y     WL  ++   + 
Sbjct: 7894 ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 7953

Query: 3877 LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGEGFSIQEKYVA 3935
              +  + Y   +++ ++    +  + E    ++ +NK   +L  E       S+++    
Sbjct: 7954 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHE 8013

Query: 3936 ADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS-AEVE- 3993
             +  +  +++ V      L   I Q  +F    D IL  L  +  +L      S  +V+ 
Sbjct: 8014 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQA 8073

Query: 3994 KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIW 4053
            KIK+  +  + +S++  K+    E +  +GE++I +S    + + A  ++++LD++    
Sbjct: 8074 KIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIEEELDELRRYC 8125

Query: 4054 ENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS-LIVTIKDTQD 4093
            + +   VE                   +RE +L D   L++  W D  +  +++ + + +
Sbjct: 8126 QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 8185

Query: 4094 FIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC---------- 4143
                L  P      ++ ++   +T    +D +  E D   +L  +L +A           
Sbjct: 8186 LSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 8238

Query: 4144 GEPDKPIVKKS--------IDELNSAWDSLNKAWKDRIDKLEEAMQAAV-QYQDGLQAVF 4194
            G+ DK    +         I E   A+  L +           A+++ + Q    L    
Sbjct: 8239 GQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSR 8298

Query: 4195 DWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE 4254
              +      + S +P G +L+T  +   +L     E       ++RL H+ +   + +  
Sbjct: 8299 FQIQQTENIIRSKTPTGPELDTSYKGYMKLL---GECSSSIDSVKRLEHKLKEEEESLPG 8355

Query: 4255 ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLL 4314
              + H+ +     +   W+ L+ + ++++ +++  L    QF   L+ + AWL  TE  L
Sbjct: 8356 FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEEL 8415

Query: 4315 SEQK--PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4372
             + +   +  D + IE+++ K   LQ  V   ++ + ++N    +  ++ + +E+ +LQ+
Sbjct: 8416 EQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQD 8474

Query: 4373 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4432
            +L  +N RW  V    E+ +  L  AL Q +GFH     L   L + +R      P+   
Sbjct: 8475 RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS- 8533

Query: 4433 PETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDINN 4485
                    N+  E+       ++ +K LMQ   ++L       +    S +  ++ +  +
Sbjct: 8534 --------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTD 8579

Query: 4486 LKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4529
              E  E V    N  K  L+E       L   ++  +S QD  +W +  E
Sbjct: 8580 CLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 8629



 Score =  264 bits (674), Expect = 2e-69
 Identities = 859/4708 (18%), Positives = 1825/4708 (38%), Gaps = 698/4708 (14%)

Query: 581  LMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLEN 640
            L+++ K  L+S  +   L E E   + +Q +  WV  +Q   DR      L   ES L +
Sbjct: 2615 LLRMTKEKLRSCQVA--LQEHEALEEALQSMWFWVKAIQ---DR------LACAESTLGS 2663

Query: 641  HKNVHRAIEEFESSLKEAKISEIQMTAPL--------------KLTYAEKLHRLESQYAK 686
               + + + + +  L      E+++   +              +     +L  L+  +A 
Sbjct: 2664 KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWAD 2723

Query: 687  LLNTSRNQERHLDTL----HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 742
            ++++S + +  L+++    +++V R      W+ E  ++++ +    +   +  K     
Sbjct: 2724 IMSSSVHAQSTLESVISQWNDYVERKNQLEQWM-ESVDQKIEHPLQPQ-PGLKEKFVLLD 2781

Query: 743  ELMRELDQKEENIKSVQEIAEQL--LLENHPARLTIEAYRAAMQTQWSWILQLCQ----C 796
             L   L + E++ +++  +  +   L E        +  +  ++TQ++ I+ + +     
Sbjct: 2782 HLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRK 2841

Query: 797  VEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 856
            VE+ +K++  Y +  +   E TD+L + K+ + R       SS        Q+ + + +E
Sbjct: 2842 VEEIVKDHLMYLDAVH---EFTDWLHSAKEELHRWSDMSGDSSA------TQKKLSKIKE 2892

Query: 857  LLQYKSTIANLMGKAKTIIQLKPRN---SDCPLKTSIPIKAICDYRQIEITIYKDDECVL 913
            L+  +   A+ + + +++     +N   S C L  +       D++Q E ++++   C L
Sbjct: 2893 LIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSC-L 2951

Query: 914  ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 973
             N   +        +G  A +           ++A++  + + + +   LTL    + + 
Sbjct: 2952 ENLVSQMALSEQEFSGQVAQL-----------EQALEQFSALLKTWAQQLTLLEGKNTDE 3000

Query: 974  KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 1033
            + V  WH     +D ++ +   +              +L+S+  +    S++   +SG  
Sbjct: 3001 EIVECWHKGQEILDALQKAEPRT-------------EDLKSQLNELCRFSRDLSTYSGK- 3046

Query: 1034 ITQLEKEVN-VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 1092
            ++ L KE N +C Q       S   + +E+ +   +    R+ +  L N +    +    
Sbjct: 3047 VSGLIKEYNCLCLQ------ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDI 3100

Query: 1093 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 1152
            P    ++  S+ +I E      E E  +  L  + +K  E  S          +++++  
Sbjct: 3101 PQNISEVSTSLQKIQE---FLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQAKVTA 3156

Query: 1153 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1212
              ++    +S        L+ + + +K+ + +   ++ + +K   E+ V    N + +L 
Sbjct: 3157 AKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKT--EKMVHESSNRLYDLP 3214

Query: 1213 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMF------KTYKERDLDFDWH------ 1260
            +  ++ + ++    +  H  E +L + K  + +++      K+++ R             
Sbjct: 3215 AKRRE-QQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN 3273

Query: 1261 --KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY-HPLDDW------------ 1305
              KEK  +L +R    H Q    +++L+       +  D+Y HP  D             
Sbjct: 3274 LTKEKVSRL-DRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3332

Query: 1306 ---IQQVETTQRK---------IQENQPENSKTLATQLNQQK-----MLVSEIEMKQSKM 1348
               ++Q +  Q K         +Q   PE   T+  QL   K     +L + I  K    
Sbjct: 3333 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3392

Query: 1349 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR---RMQSSADLIIQEFMDLRT 1405
                K+   Y   V+ +     +  A ++  ++   + R    M   A L+ +E +    
Sbjct: 3393 GALSKWTS-YQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLS--- 3448

Query: 1406 RYTALVTLMTQYIKFAGDS--------LKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1457
             Y++L  L T  +K AG +        L+ L+E  ++++E  KE V K+++L +      
Sbjct: 3449 -YSSL--LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ 3505

Query: 1458 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1517
            + LK  E                       L +  + +  +    GD  T E      ++
Sbjct: 3506 RDLKAFEV---------------------WLGQEQEKLDQYSVLEGDAHTHETTLRDLQE 3544

Query: 1518 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1577
            ++        L +  L   ++   SG  + E++ +   +Q+++     + +  TQ  N  
Sbjct: 3545 LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN-- 3602

Query: 1578 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL--KENGEKLSQE 1635
                   ++    +  +K+Q   E L+          AE  K  E     ++  E++   
Sbjct: 3603 -------VVNKLRLMEQKFQQVDEWLKT---------AEEKKWHEEVTAYRDEVEEVGAR 3646

Query: 1636 DKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIEN 1695
             + ++++    +++ C+   L +      L  +      EE      ++ LEES++ + +
Sbjct: 3647 AQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEE-----IQSLEESESSLSS 3701

Query: 1696 LLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGT 1755
              DW  +  K+ +   TK  +V                            +T + G+   
Sbjct: 3702 YSDWYGSTHKNFKNVATKIDKV----------------------------DTVMMGKKLK 3733

Query: 1756 TQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----NM 1811
            T E L +  +K  +                +SA+   E+  +YL   E E+L+K    +M
Sbjct: 3734 TLEVLLKDMEKGHS--------------LLKSAREKGERAVKYLEEGEAERLRKEIHDHM 3779

Query: 1812 KELKVHYETALAES---EKKMKLTHSLQEE---LEKFDADYTEFEHWLQQSEQELENLEA 1865
            ++LK    T   E    EK + L     ++   L ++ A+Y E  H  ++ + EL   +A
Sbjct: 3780 EQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3839

Query: 1866 GADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRD------GGKV 1919
                      +L + KS  + V+SH+  ++ +   G  +LE  +  + +D          
Sbjct: 3840 ----------QLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQ 3889

Query: 1920 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK------YQHYE------DAS 1967
            D  +  + +  ++    DR  +L  K + L     D +        + H +       A 
Sbjct: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949

Query: 1968 CGLLAGL-QACEATASKHLSEPIAVDP-----KNLQRQLE---ETKALQGQISSQQVAVE 2018
            C     + Q+ E    KH+S    +         +Q  LE   +    + +   Q     
Sbjct: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4009

Query: 2019 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2078
             L++ A   LD   S+    N   KT           +K + +  + ++  L ++ ++  
Sbjct: 4010 ALQEQARTYLDLLCSMCDLSNASVKTT----------AKDIQQTEQTIEQKLVQAQNLTQ 4059

Query: 2079 GLDEMLDWMGNVESSLKEQGQV---------PLNSTALQDIISKNIMLEQDIAGRQSSIN 2129
            G +E+      +   L++  Q           L     Q+++S+     + +  +Q+S+N
Sbjct: 4060 GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVN 4119

Query: 2130 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2189
             + EKV K  +  +    S    ++  L+ ++ +   +      + EE   +   + +  
Sbjct: 4120 TIIEKVNKLTKKEE----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175

Query: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFL----EHKKHLEVLHSLLKEIS 2245
              ++ FLE  T   TE D   +   E +    E+  +      E K  +E L    +++ 
Sbjct: 4176 NVVEVFLEKFT---TEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMI 4232

Query: 2246 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2305
             H    DK LV E+T++L +++ ++ED IK K +   +  E+L+  Q   + L  W +E 
Sbjct: 4233 EHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ 4292

Query: 2306 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKA 2365
                   QP+  AE L            K S      Q +    +++C+ + A     K+
Sbjct: 4293 -------QPNI-AEAL------------KQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332

Query: 2366 IAAVKSGGAVLNGEGTATNTEEFWANKGLTS---IKKDMTDISHGYEDLGLLLKDKIAEL 2422
            +  +K    V+             A+ GL     I+K ++D       L  L+  +   L
Sbjct: 4333 L--IKDADRVM-------------ADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYL 4377

Query: 2423 NTKLS-KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2481
            N  LS K Q       A  Q  Q   K   +      P D   V  QV+  KS +A LK 
Sbjct: 4378 NKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD---VSKQVKTCKSAQASLKT 4434

Query: 2482 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2541
              N+V  L  +  EL++E  +  E       L E+ S +  + Q    R Q+LE++  + 
Sbjct: 4435 YQNEVTGLWAQGRELMKEVTE-QEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4493

Query: 2542 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2601
              F+    +   WL + +++      L  + + L+TQ  + Q +L++     P+YE L  
Sbjct: 4494 KHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ----SPEYENLLL 4549

Query: 2602 AGQGILSRPGED--PSLRGI----VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQY 2655
                 L R G+   PSL  +    + E+L A+ ++++ +     D+   + +AI+   +Y
Sbjct: 4550 T----LQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4605

Query: 2656 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 2715
             SL+   +  LS+L+ +      V T     +  +E A  ++   +    ++       +
Sbjct: 4606 ASLIELTTQSLSELEAQFLRMSKVPT-----DLAVEEALSLQDGCRAILDEVAGLGEAVD 4660

Query: 2716 DLSALVKEEYLKAELSRQLEGIL---KSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF 2772
            +L+   KE +       Q + +L     +  ++++ E  V  L+   ++  + ++M +  
Sbjct: 4661 ELNQ-KKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4719

Query: 2773 QAWLDTKKEEQNKSH----PISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828
            +  L + KEEQ+K +    P   KL +  SL    +D    L   +   E          
Sbjct: 4720 ERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPH----- 4774

Query: 2829 LKTQGSEKAALQLQ--LNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWID 2886
            L     EKA  Q+Q     +K       + V E E+++ +S++    ++ ++     W+ 
Sbjct: 4775 LDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID----FQTEMSRSLDWLR 4830

Query: 2887 KCQNNLE-EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2945
            + +  L   +   L+  + +  I K++  Q+E+     ++  L++      +     KE+
Sbjct: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA---KEL 4887

Query: 2946 VT-DENKSLIQKVDM---VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDI 3001
            ++ D   SL +  ++   + E L +++  L  +  + + + +V + +   L+ A+E L +
Sbjct: 4888 ISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQL 4947

Query: 3002 H----DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLL 3057
                 D   ++     ++    T+ +    L+    L   L  D +++ +   G  D+  
Sbjct: 4948 AGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATL--DPLIKPT---GKEDLEQ 5002

Query: 3058 QVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD 3117
            +V ++      +S+    +   L+        +Q    E+     + + +L   + +   
Sbjct: 5003 KVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTS 5062

Query: 3118 A-----ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL--VGIKRDLE 3170
            +     E L + K  +       E ++A  + A++        E+T  D     + R + 
Sbjct: 5063 SSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ-------LEKTGNDASKATLSRSMT 5115

Query: 3171 ALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEH---EESQGPVGME 3227
             + ++  +L   AQ +E+ +E  +     F +K+K+ + ++ + ++      ++     E
Sbjct: 5116 TVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAE 5175

Query: 3228 TETINQQLNMFKVFQKEEIEPLQG--KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNA 3285
              T+ +  + F V + E+ +   G  +QQ ++ L  G   +A        L  ++  +  
Sbjct: 5176 LLTLLEYHDTF-VLELEQQQSALGMLRQQTLSMLQDG---AAPTPGEEPPLMQEITAMQD 5231

Query: 3286 RWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ 3345
            R   + +KV      +++ L      +  + S+  W+ +T+E + N   P+ E   + AQ
Sbjct: 5232 RCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN---PTIE---IDAQ 5285

Query: 3346 IQE-QKLLQRLLDDRKSTVEVIKREGEKI--ATTAEPADKVKILKQLSLLDSRWEALLNK 3402
            ++E Q LL    + R++  ++ + + EK     T  P++    L +++ LD +   + ++
Sbjct: 5286 LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVA-LDLK---IRDQ 5341

Query: 3403 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3462
             + + +++E     +Q+    ++ L + LTTI  +L        +   + +     K L 
Sbjct: 5342 IQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKL------KAKTDNVVQAKTDQKVLG 5395

Query: 3463 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQA 3522
            +++   N  L +  +  Q     + +  K + +     +++    I++ + +R   L QA
Sbjct: 5396 EELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQ-AENRLSKLNQA 5454

Query: 3523 LCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQ 3579
              + + + E    ++ W       + K  V  + T   W   S+LR   +L + +L   +
Sbjct: 5455 ASHLEEYNEMLELILKW-------IEKAKVLAHGTIA-WNSASQLREQYILHQTLLEESK 5506

Query: 3580 NVDQALLNGLELLKQTT--------GDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQA 3631
             +D  L    E L+  T          +V  +  + E ++   K   +   D AK +++ 
Sbjct: 5507 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKF 5566

Query: 3632 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLD 3691
                ++L +  E+    L   EV  LS + Q+             + L  E ++ K  + 
Sbjct: 5567 EAELKKLQAALEQAQATLTSPEVGRLSLKEQL----------SHRQHLLSEMESLKPKVQ 5616

Query: 3692 SLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAA 3751
            ++    SAL       A   L        E    +  T  Q+   + AA+++ +Q++Q  
Sbjct: 5617 AVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM 5676

Query: 3752 DAELSWITETEKKLMSL--GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKI 3809
                       K L  L  G  R  +D+  A   +Q+    +I RH+++   +     +I
Sbjct: 5677 -----------KHLQQLIEGAHREIEDKPVATSNIQE-LQAQISRHEELAQKIKGYQEQI 5724

Query: 3810 MTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE 3869
             +  S+ +  +MK K              ++   L +   + L     +   EL P  + 
Sbjct: 5725 ASLNSKCKMLTMKAK--------------HATMLLTVTEVEGLAEGTEDLDGELLPTPSA 5770

Query: 3870 TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSI 3929
              S++                   H  L        P  ++  + G      SP    + 
Sbjct: 5771 HPSVVMMTAGRC------------HTLL-------SPVTEESGEEGTNSEISSPP---AC 5808

Query: 3930 QEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS 3989
            +     A+T  S  ++    +A++ +   + + + H       E  E  +E     PS +
Sbjct: 5809 RSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLE-----PSAT 5863

Query: 3990 AEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQM 4049
            A++  ++      KNV    EK + LYE L+++                 +  QD L   
Sbjct: 5864 AKLGDLQRSWETLKNVI--SEKQRTLYEALERQ-----------------QKYQDSL--- 5901

Query: 4050 VFIWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIKDTQDFIRDL-------- 4098
                ++I T +E  E KL +  E     E    +H +L+  I   QD I +L        
Sbjct: 5902 ----QSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEEL 5957

Query: 4099 --EDPGIDP-------SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP 4149
              E    DP       S +    E   TIR +  G ++ L+  +N   +L     E    
Sbjct: 5958 VSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN--DQLEEQRQEQALQ 6015

Query: 4150 IVKKSIDELNSAWDSLNKAWKD-RIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS 4208
              +   DEL+S W    KA  D  +   +E M    Q  D    + +       K+ ++S
Sbjct: 6016 RYRCEADELDS-WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVE----IEQKVVALS 6070

Query: 4209 PIGTDLETV--------KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT 4260
             +    E +        K + E+L           +E++R  H  +L ++   +E ++  
Sbjct: 6071 ELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESD 6130

Query: 4261 ----------VQDPLMELKLIWDSLEERIINRQHKLEGAL----------LALGQ---FQ 4297
                      VQ+ L + +  W    +  + +Q +LE  L           + G+    Q
Sbjct: 6131 VDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQ 6190

Query: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIEL------------AKHHVLQNDVLAHQ 4345
            H+  E          +LS++  + G+  + E ++             K  +LQN  +  Q
Sbjct: 6191 HSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQN--VLEQ 6248

Query: 4346 STVEAVNKAGNDLIE-------SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4398
               + +    N L+            ++ S + + L+ LNQ ++ V  ++   K+Q   +
Sbjct: 6249 EQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---S 6305

Query: 4399 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4458
            +   +  +  +     WL D E  L  +  L  LPE  +  L  + E+ A  + KE + +
Sbjct: 6306 IHLEQKLYDGVSATSTWLDDVEERLFVATAL--LPEETETCL-FNQEILAK-DIKEMSEE 6361

Query: 4459 SLMQKGQQMLARC-PKSAETN--IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFH 4515
              M K + + ++  P++ +    I+  +  L  +   +++ +N+R  +++E L   + F 
Sbjct: 6362 --MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQ 6419

Query: 4516 NSLQDFINWLTQ-----AEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELD 4570
            N L+     L        ++  NV  +P      V  QI+  +   + +      IIEL 
Sbjct: 6420 NDLKVLFTSLADNKYIILQKLANVFEQP------VAEQIEAIQQAEDGLKEFDAGIIELK 6473

Query: 4571 KTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKL 4630
            + G  L+              L  +Q  +++++  +  R   L+       Q+  A   L
Sbjct: 6474 RRGDKLQVEQPSMQE------LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDL 6527

Query: 4631 MEWLEE-SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT 4689
             + LE   EK    +  I +  ++I+  L +HKE+ + L +   + +T  R   S   + 
Sbjct: 6528 ADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ- 6586

Query: 4690 SLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
                   K     +EL  +   +  ++ +R  +LE  L       +  Q L   L  VE 
Sbjct: 6587 -------KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVES 6639

Query: 4750 QLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELIEGSRDDSSWVKV 4808
             +     V  + D +++ I  ++  +  L + +    Q L    R LI  S  D   ++ 
Sbjct: 6640 SIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LES 6696

Query: 4809 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRF----HGV 4864
            Q+ +L   W +       +  RLE  L+    + S    L+ WL  A+  L F       
Sbjct: 6697 QLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVT 6756

Query: 4865 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4924
            +P + + +R  ++   EF K+++ + +  +   + G+ +L +   D+  T++  ++ I +
Sbjct: 6757 VPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDT-ATLRSELSRIDS 6815

Query: 4925 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI--EE 4982
            ++ ++L      Q++L       +  +  +  +++W+   E  +  KD++ I   I  + 
Sbjct: 6816 QWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI-QKDEDNIKNSIGYKA 6874

Query: 4983 VKALIAEHQTFMEEMTRKQPDVDKVTKT 5010
            +   + +++ F  ++  KQ  VD V ++
Sbjct: 6875 IHEYLQKYKGFKIDINCKQLTVDFVNQS 6902



 Score =  244 bits (624), Expect = 1e-63
 Identities = 745/4103 (18%), Positives = 1582/4103 (38%), Gaps = 573/4103 (13%)

Query: 1034 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1093
            +T LE E+NV +  +QEL++ AE ++         I+E        +  ++ L+  +   
Sbjct: 4269 VTNLE-ELNVVQSRFQELMEWAEEQQPN-------IAEALKQSPPPDMAQNLLMDHLAIC 4320

Query: 1094 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 1153
             E +     +      + L K+ +R+  DLG      E    Q A S +    +S +N  
Sbjct: 4321 SELEAKQMLL------KSLIKDADRVMADLGLN----ERQVIQKALSDA----QSHVNC- 4365

Query: 1154 LQNMNQVYSMSSTYIDK-LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1212
               ++ +      Y++K L      L     A + ++ +E K+   E +    +++   +
Sbjct: 4366 ---LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV 4422

Query: 1213 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 1272
             T K  ++ +          ++E+    A   E+ K   E++      K +  Q V  + 
Sbjct: 4423 KTCKSAQASLK-------TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSV--YD 4473

Query: 1273 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1332
            +V  +  +RL++LE    S K++++ +     W++Q +      + N    S  L TQL 
Sbjct: 4474 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFP-EINLMNESSELHTQLA 4532

Query: 1333 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1392
            + + ++ +    ++ +   Q+  +    ++ + +   ++ +     +Q + +    +   
Sbjct: 4533 KYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVA--LAKD 4590

Query: 1393 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE--------EEEKSLEEEKKEHVE 1444
                +QE +  R  Y +L+ L TQ +        R+         EE  SL++  +  ++
Sbjct: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILD 4650

Query: 1445 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD 1504
            +   L + V  +++  +     G+P                 Q  + L  + L+   H  
Sbjct: 4651 EVAGLGEAVDELNQKKEGFRSTGQP----------------WQPDKMLHLVTLY---HRL 4691

Query: 1505 KMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQ 1564
            K   E+R  L +   +  + +  +  +  +QL+  +       EE + AE + +    L 
Sbjct: 4692 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4751

Query: 1565 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENF 1624
            G          R+  H E        +  +K + + +  Q +++    A+ E V   E+ 
Sbjct: 4752 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4811

Query: 1625 LKENGEKLSQEDKAL---------------IEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1669
            + ++ +  ++  ++L               ++  L + + +  ++ +  E+ +  L +++
Sbjct: 4812 MVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSL-RIM 4870

Query: 1670 TTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHK----QVIEQNGTHF 1725
                 +E EK    K+L  +   +E+ L  LS +D D + A    +    ++  Q   ++
Sbjct: 4871 NALSHKEKEKFTKAKELISAD--LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYY 4928

Query: 1726 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1785
            Q     +   E+ +    L    +D  V + +ENL          H +  S         
Sbjct: 4929 QVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKS--------HMEFFSTEDQFHSNL 4978

Query: 1786 QSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1845
            +    L+      + P  KE L++ +  L++  +    +S  ++ L      +   +   
Sbjct: 4979 EELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKA 5038

Query: 1846 YTEFEHWLQQSEQELENLEA-GADDINGLMTKLKRQK-------SFSEDVISHKGDLRYI 1897
              E    +  +E++L           +    KL   K       SF E +++ +     +
Sbjct: 5039 REEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQL 5098

Query: 1898 TISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1955
              +GN   +A  S S     +  T   A  ++ ++ L+ A D +    +K       +  
Sbjct: 5099 EKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQ 5158

Query: 1956 LVDKYQ----------------HYEDASCGLLAGLQAC---------------------- 1977
            L DK                   Y D     L   Q+                       
Sbjct: 5159 LQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGE 5218

Query: 1978 ------EATASK----HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK---TA 2024
                  E TA +    ++ E +  + K ++++L++ + ++ QI+S +  V++ K+     
Sbjct: 5219 EPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP 5278

Query: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK---LQITLTRSLSVQDGLD 2081
             + +DA+        ++Q  L +     +++ K   E+ EK   L   L   LS+Q  L 
Sbjct: 5279 TIEIDAQ------LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LA 5330

Query: 2082 EM---LDWMGNVESSLKEQGQVPLNSTALQDIISK-----------------NIM----- 2116
            E+   L     ++  +KE  Q    S  L   I K                 N++     
Sbjct: 5331 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390

Query: 2117 ---LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2173
               L +++ G  S +  ++  V+KF+E         L  K+  L+    +   + +  L+
Sbjct: 5391 QKVLGEELDGCNSKLMELDAAVQKFLEQNG-QLGKPLAKKIGKLTELHQQTIRQAENRLS 5449

Query: 2174 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL-SQYMQEST--SEFLEH 2230
            K+ +  + +E +  + E +  ++E K + L    +     ++L  QY+   T   E  E 
Sbjct: 5450 KLNQAASHLEEYNEMLELILKWIE-KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI 5508

Query: 2231 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2290
               LE +   L+ ++S       +   ++   L ++ +E+   IK + + +    + +  
Sbjct: 5509 DSELEAMTEKLQYLTSVYCTEKMS---QQVAELGRETEELRQMIKIRLQNLQDAAKDMKK 5565

Query: 2291 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2350
            F+  +K L++ +++   +  +  P  G   L + L   + L  +     P++Q V     
Sbjct: 5566 FEAELKKLQAALEQA--QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ---- 5619

Query: 2351 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG--LTSIKKDMTDISHGY 2408
             LC   SA+  P   +A++    A L  +  A+  +     +   + +            
Sbjct: 5620 -LCQ--SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM 5676

Query: 2409 EDLGLLLKDKIAELNTK---LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAV 2465
            + L  L++    E+  K    S +Q+ Q + S   +  QK+      +Q+  A  ++   
Sbjct: 5677 KHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKG----YQEQIASLNS--- 5729

Query: 2466 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQ 2525
            K ++   K+  A +   V +V+ L +   +L  E   TP A     M+T    +   L  
Sbjct: 5730 KCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTA--GRCHTL-- 5785

Query: 2526 LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2585
            L+   ++  EE +N+               +          P++     +N      Q L
Sbjct: 5786 LSPVTEESGEEGTNSE--------------ISSPPACRSPSPVANTDASVNQDIAYYQAL 5831

Query: 2586 LQE-FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2644
              E   T   +    T+A Q     PG +PS       +L  + + W++L   +S++   
Sbjct: 5832 SAERLQTDAAKIHPSTSASQEFYE-PGLEPSATA----KLGDLQRSWETLKNVISEKQRT 5886

Query: 2645 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2704
            + +A+ +  +YQ  L+S+S K+  ++ KLS S      P++   Q+   Q +  EI   +
Sbjct: 5887 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMDEILMLQ 5943

Query: 2705 KQIKVAQ-ALCEDLSALVKEEYLKAELSRQ--LEGILKSFKDVEQKAENHVQHLQSACAS 2761
             +I   Q +L E+L +   E     +L+ Q  L  + +    +  KA    Q L+     
Sbjct: 5944 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003

Query: 2762 SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMY---- 2817
              + Q+  +  Q +     E  +      A LD   S  K+  D    L    +M     
Sbjct: 6004 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6063

Query: 2818 EKTIA------EGENLLLKTQGSEK-----------------AALQLQLNTIKTNWDTFN 2854
            +K +A        ENLLL+ +   K                   LQ  L+  + N     
Sbjct: 6064 QKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTA 6123

Query: 2855 KQVKERENKLKESLEKAL-KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKS 2913
            ++ +E +  L  +    + ++  Q  T   W  + Q++L++ K      E E  +A+ KS
Sbjct: 6124 QEKEESDVDLTATQSPGVQEWLAQART--TWTQQRQSSLQQQK------ELEQELAEQKS 6175

Query: 2914 LQKE---------------------------MDQHFGMV--------------ELLN--- 2929
            L +                            + Q  GM               E L+   
Sbjct: 6176 LLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEF 6235

Query: 2930 NTANSLL-SVCEIDKEVV--TDENKSL----IQKVDMVTEQLHSKKFCLENMTQKFKEFQ 2982
            +T   LL +V E ++E V  +  N+ L    + K D+ T+   +    L+ + Q F+E  
Sbjct: 6236 STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS 6295

Query: 2983 EVSKESKRQLQCAKEQL------------DIHDSL--GSQAYSNKYLTMLQTQQ---KSL 3025
              S  +KRQ    +++L            D+ + L   +     +  T L  Q+   K +
Sbjct: 6296 SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI 6355

Query: 3026 QALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ 3085
            + +  ++D  K L      E  D++   +  L    +    S L   V+++C  ++ +LQ
Sbjct: 6356 KEMSEEMDKNKNLFSQAFPENGDNRDVIEDTL--GCLLGRLSLLDSVVNQRCHQMKERLQ 6413

Query: 3086 GIGHFQNTIREMFSQFAEFDDE---LDSMA-----PVGRDAETLQKQKETIKAF------ 3131
             I +FQN ++ +F+  A  D++   L  +A     PV    E +Q+ ++ +K F      
Sbjct: 6414 QILNFQNDLKVLFTSLA--DNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIE 6471

Query: 3132 -LKKLEALMASNDNANKTCKMMLATEETSPDL----VGIKRDLEALSKQCNKLLDRAQAR 3186
              ++ + L     +  +  K+    +E    +     G+ ++L   S+    L D A   
Sbjct: 6472 LKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLL 6531

Query: 3187 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEI 3246
            E   E      +   S  +E   LL K +E+ +      + TET+ +++  F V      
Sbjct: 6532 ETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAV------ 6585

Query: 3247 EPLQGKQQDVNWLGQGLIQSAA--KSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3304
                  Q++  +  + + Q++A  K    +G+E  L+ +   W  L++   + + QL   
Sbjct: 6586 ------QKETQFHTELMAQASAVLKRAHKRGVE--LEYILETWSHLDEDQQELSRQL--- 6634

Query: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQE-QKLLQRLLDDRKSTV 3363
                    + +ES +  +   EE           ++ +K+ + E Q  L ++LDD     
Sbjct: 6635 --------EVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDD----- 6681

Query: 3364 EVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET 3423
                  G+++  +   +D   +  QL+ L   W +  NK      +LE I     ++   
Sbjct: 6682 ------GKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSE 6732

Query: 3424 LEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLK 3483
               L  WL + + RL       TQ S     + Q   +  D +N      + V    SLK
Sbjct: 6733 SADLIHWLQSAKDRL----EFWTQQS---VTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6785

Query: 3484 --VLSS--------REDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDE 3533
              VLS+        + D   ++S+L      + ++     +  E L Q   +        
Sbjct: 6786 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 6845

Query: 3534 VELMNWLNEVHDKLSKLSVQDYSTEG---LWKQQSELRVLQEDILLRKQNVDQALLNGLE 3590
             E+M+W++ + + + K      ++ G   + +   + +  + DI  ++  VD    + L+
Sbjct: 6846 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 6905

Query: 3591 LLKQ---TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3647
            +  Q   +   +     ++L A+   ++ +  L T+  + LE  L+      +  + L T
Sbjct: 6906 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 6965

Query: 3648 WLDKVEVELLSYETQVLKGEEAS-------------QAQMRPKELKKEAKNNKALLDSLN 3694
            W +  E  L   + Q   G++AS               + + KE++K  +N  AL+ +  
Sbjct: 6966 WFETQEKRL---KQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKK 7022

Query: 3695 E-----VSSALLELVPWRAR--------EGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3741
            E     V S L EL    A         + L K V +    +++  D I   + E   ++
Sbjct: 7023 EDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSL 7082

Query: 3742 LRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDD 3801
             R +    + +A    +      L +L D  LE+ + S Q            +   I + 
Sbjct: 7083 SRFRLLTGSLEA----VQVQVDNLQNLQD-DLEKQERSLQ------------KFGSITNQ 7125

Query: 3802 LVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYE 3861
            L+K  H  +T       +++   L +V   ++ + +  +E   QL+ +++L+ Q W+ Y+
Sbjct: 7126 LLKECHPPVT-------ETLTNTLKEVNMRWNNLLEEIAE---QLQSSKALL-QLWQRYK 7174

Query: 3862 ELWPWLTETQSIISQLPAPALEYETLRQQQEEH--------RQLRELIAEHKPHIDKMNK 3913
            +       T           L+  T +   ++           L + +   K  +  +++
Sbjct: 7175 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHE 7234

Query: 3914 TGPQL-LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 3972
             G QL  ++      +IQ   ++       +++ + K+  +L   +     F   ++ + 
Sbjct: 7235 LGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALE 7294

Query: 3973 ESLERIVERLR-QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSG 4031
              +    E L+ Q PS S+++  I+E++ E K   +    + P  + L + G  +     
Sbjct: 7295 AWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--- 7351

Query: 4032 GTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDT 4091
              DK+I       ++  +   W  I +   ER +KL       + F   H + +   +  
Sbjct: 7352 -NDKEIK------RMQNLNRHWSLISSQTTERFSKL-------QSFLLQHQTFLEKCETW 7397

Query: 4092 QDFIRDLEDP-GIDPS----VVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4146
             +F+   E    ++ S     + +QQ A E  + E+   Q+ L  +I  G  L+      
Sbjct: 7398 MEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVD 7457

Query: 4147 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW-VDIAGGKLA 4205
            D+      +  L++ W  + +  + R   ++  ++   +Y++  + +  W V+++   ++
Sbjct: 7458 DRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMS 7517

Query: 4206 SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPL 4265
             +  +   L+  +   +E+ QFK + + +Q     L  +A   L    +   +  +Q  L
Sbjct: 7518 GLGSVPIPLQQARTLFDEV-QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAEL 7576

Query: 4266 MELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPK 4325
             E++  W S   R+  ++ KL   L    + +  + + L  L   +  LS+  P     +
Sbjct: 7577 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--DHHE 7634

Query: 4326 AIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVL 4385
             +  E  +   L+N V +    +  ++   + L    + ++ S L  ++E+L ++W+ + 
Sbjct: 7635 ELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC 7694

Query: 4386 EKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHME 4445
             +   R+QQ+   L +   F  + ++L +WLT  E  +  +  +       K + +   E
Sbjct: 7695 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEE 7754

Query: 4446 VCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE 4505
            +  A E K +    L Q G+++     +S  + I+  +  + ++W+ +   +  R  KL+
Sbjct: 7755 IAIAQENKIQ----LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK 7810

Query: 4506 EALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQ 4565
            E L    +   ++     WL   E  L   ++P      +++     +    ++N  +E 
Sbjct: 7811 ETLVAVQQLDKNMSSLRTWLAHIESEL---AKP------IVYDSCNSEEIQRKLNEQQEL 7861

Query: 4566 IIELDKTGTHLKYFSQKQDVVL--------------IKNLLISVQSRWEKVVQRLVERGR 4611
              +++K  T +       +V+L              I+    ++  RW  +    +ER  
Sbjct: 7862 QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRL 7921

Query: 4612 SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAK 4671
             +++  +  ++F + +S+  +WL+ SE++              K +L + + FQ+ +   
Sbjct: 7922 KIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHEC 7981

Query: 4672 HSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSG 4731
             +  +  N+  R L  + +  D    L  M+ E   +WD +  +      +L+  +    
Sbjct: 7982 LTQLELINKQYRRL-ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE 8040

Query: 4732 QFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4791
            +F  A  +++ WL  ++ QL   +  H     V   I   KAFQ+E+    + ++ +   
Sbjct: 8041 EFETARDSILVWLTEMDLQLTNIE--HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQ 8098

Query: 4792 ARELIEGSRD-DSSWVKVQMQEL 4813
              +LIE S   D++ ++ ++ EL
Sbjct: 8099 GEQLIEKSEPLDAAIIEEELDEL 8121



 Score =  243 bits (621), Expect = 3e-63
 Identities = 877/4762 (18%), Positives = 1749/4762 (36%), Gaps = 848/4762 (17%)

Query: 591  SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 646
            S  L++N+    +++    D+L+  DE++       W ++ +P +    S+L+NH     
Sbjct: 2189 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2242

Query: 647  AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 692
             ++EFES +K          +K+++++     +  P  L + E     + ++AK +    
Sbjct: 2243 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2299

Query: 693  NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 747
              E    TL +F +++T    ++N+      + EE   + ++  T  A KK    ++ +E
Sbjct: 2300 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2355

Query: 748  LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 798
            L  ++ NI S QE    L  + H A L          I+ + A  Q        L + +E
Sbjct: 2356 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2415

Query: 799  QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 857
            +H  E+   F E+F  AK A             K S DR+     LE  + +     + +
Sbjct: 2416 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2463

Query: 858  LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 917
               +S +  +  + +T+                       +   +I     ++   AN  
Sbjct: 2464 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2502

Query: 918  HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 976
             +A  K              C       ++        E Q++  L LW HE        
Sbjct: 2503 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2542

Query: 977  VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1030
                      +R    N+   K  +P +  +V      L  L +  E   + SQ  Q+ S
Sbjct: 2543 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2592

Query: 1031 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1083
              +     +E  +C Q    +Q LL+  + + +   V    +      ++++   ++  +
Sbjct: 2593 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2651

Query: 1084 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1142
            DRL     T   +D L + + +I +   +K E E +L   +G           + A  SS
Sbjct: 2652 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2702

Query: 1143 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1197
                +  +   L+ + +V++ + S+ +    T+  V+       +    L +  E+   +
Sbjct: 2703 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2762

Query: 1198 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1253
             E  +  +  ++     L   +S + E      AL   + K++ +     DE FK   + 
Sbjct: 2763 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2821

Query: 1254 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1313
                       ++L  ++ ++      ++R +E I K    Y D  H   DW+   +   
Sbjct: 2822 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870

Query: 1314 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1371
             +  +   ++S T   +L++ K L+   E+  S++   +  A +   + T    EL    
Sbjct: 2871 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2929

Query: 1372 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1417
             +A+        DS  ++      + S   L  QEF            +++AL+    Q 
Sbjct: 2930 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2989

Query: 1418 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
            +                       D+L++ E   + L+ +  E    +++L  +   +S 
Sbjct: 2990 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3049

Query: 1459 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1512
             +K+      +A K   +K++I  +          + L   ++  AK  D  +   E   
Sbjct: 3050 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3109

Query: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
             L+K  + L ES N        +L    + G++              KEK +GI   +T 
Sbjct: 3110 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3156

Query: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1632
             +             +  +E  K Q       KD + SA+ + + +  TE  + E+  +L
Sbjct: 3157 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3210

Query: 1633 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1687
                  + ++  ++  L E      QLN   E++            ++  E  AA K   
Sbjct: 3211 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3258

Query: 1688 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1747
               +++ +    LSN+ K  E+     + V E N   F  G  +      D ++      
Sbjct: 3259 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3308

Query: 1748 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1804
             +D     T +      + +K +    + Q + +   +I T+   VL     Q  SPE  
Sbjct: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3363

Query: 1805 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1864
              +Q+ ++ +K  + + L+   +          +   +     +F  W+   E  L   E
Sbjct: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423

Query: 1865 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1924
                ++    T L + K  +E+V+S+   L  I + G  + E                  
Sbjct: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3465

Query: 1925 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1984
            H   Q +L    +R+R++  +        + LV  +Q Y+         L+A E    + 
Sbjct: 3466 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3518

Query: 1985 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 2044
                        Q +L++   L+G   + +  +  L++      + +  L    N +  T
Sbjct: 3519 ------------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALL----NSVLHT 3562

Query: 2045 LDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNS 2104
             +D++         + +  ++   +L +            DW          Q ++    
Sbjct: 3563 REDVI------PSGIPQAEDRALESLRQ------------DWQA-------YQHRLSETR 3597

Query: 2105 TALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE- 2163
            T   ++++K  ++EQ           ++E +K   E       ++ + +++++ AR  E 
Sbjct: 3598 TQFNNVVNKLRLMEQ-------KFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEI 3650

Query: 2164 --ASHKHKETLAKMEELKTK--------VELFENLSEKLQTFLETKTQALTEVDVPG--- 2210
               SH +     +  +L ++        +E  + L E++Q+  E+++   +  D  G   
Sbjct: 3651 LDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTH 3710

Query: 2211 KDVTELSQYMQESTSEFLEHK-KHLEVL-------HSLLKEISSHGLPSDKALVLEKTNN 2262
            K+   ++  + +  +  +  K K LEVL       HSLLK     G  + K L   +   
Sbjct: 3711 KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER 3770

Query: 2263 LSK-------KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQP 2314
            L K       + KE+  T++++   +         F    K+L  WI E  + + +  +P
Sbjct: 3771 LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830

Query: 2315 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2374
                 +    L   K LQ+      P ++ V   G +L  L+  VT   K I  ++S   
Sbjct: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK-IDQLQSDYQ 3889

Query: 2375 VLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI-------------- 2419
             L   G A   E       L +++ K  T I    + L   LK  +              
Sbjct: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949

Query: 2420 --------AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2471
                      L  +L K    Q+       WL     +A +    P+P    +    ++Q
Sbjct: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWL-----SAVQPDLEPSPQPPLSRAEAIKQ 4004

Query: 2472 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK----------WQ 2521
             K F A L++      +L   + +L   +  T  A   +Q    I+ K          W+
Sbjct: 4005 VKHFRA-LQEQARTYLDLLCSMCDLSNASVKT-TAKDIQQTEQTIEQKLVQAQNLTQGWE 4062

Query: 2522 ELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ 2581
            E+  L  +    L+++   L   +   ++L+               L+I  NM++  +  
Sbjct: 4063 EIKHLKSELWIYLQDADQQLQNMKRRHSELE---------------LNIAQNMVSQVKDF 4107

Query: 2582 VQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2641
            V+ L  + A+     E++       L++  E P       +++  +  +W  L  Q ++ 
Sbjct: 4108 VKKLQSKQASVNTIIEKVNK-----LTKKEESPE-----HKEINHLNDQWLDLCRQSNNL 4157

Query: 2642 CDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVST--HPDAMNQQLETAQKM 2696
            C   ++ + ++  Y   +  +    +K +   + L+ S A ST  H +A+ +     Q+ 
Sbjct: 4158 CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQER 4217

Query: 2697 KQEIQQEKKQ-IKVAQALCEDLSALVKEEYLKAELS-RQLEGILKSFKDVEQKAENHVQH 2754
            K  I+  K Q  K+ + L  D   LVKE+    E    QLE ++K      +K +  V +
Sbjct: 4218 KYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK------RKIQVSVTN 4271

Query: 2755 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQS 2814
            L+       +FQ++      W + ++    ++   S   D+ ++L+ DH      L A+ 
Sbjct: 4272 LEELNVVQSRFQEL----MEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4327

Query: 2815 HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKY 2874
             + +  I + + ++     +E+  +Q  L+  +++ +  +  V +R    ++ L KAL  
Sbjct: 4328 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQR----RKYLNKALSE 4383

Query: 2875 KEQ-VETLWPWIDKCQNNLEEIKF----CLDPAEGENSIAKLKSLQKEMDQHFGMVELLN 2929
            K Q +  ++    + Q +  +I F    CL P +    +   KS Q  +  +   V  L 
Sbjct: 4384 KTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLW 4443

Query: 2930 NTANSLL-SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 2988
                 L+  V E +K  V  + + L    D V ++   +   LE      K F+E   ++
Sbjct: 4444 AQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4503

Query: 2989 KRQLQCA-----------KEQLDIHDSLG--------SQAYSNKYLTMLQTQQ------- 3022
               L+ A            E  ++H  L         S  Y N  LT+ +T Q       
Sbjct: 4504 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN 4563

Query: 3023 --------KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3074
                    + L AL  Q ++   LA+D   +  ++     +L +     +E+++L +   
Sbjct: 4564 EVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEA-----ILAR-----KEYASLIELTT 4613

Query: 3075 EKCSFLETKLQGIGHFQN--TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3132
            +  S LE +   +        + E  S        LD +A +G   + L ++KE  +   
Sbjct: 4614 QSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFR--- 4670

Query: 3133 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3192
                    S     +  KM+         LV +   L+  ++Q   LL+   +  ++ E 
Sbjct: 4671 --------STGQPWQPDKML--------HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK 4714

Query: 3193 TIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 3252
              ++LE     +K             E Q  V  ET    ++L M+          L G 
Sbjct: 4715 MCQQLERQLKSVK-------------EEQSKVNEETLPAEEKLKMY--------HSLAGS 4753

Query: 3253 QQDVNWLGQGL---IQSAAKSTSTQGLE---HDLDDVNARWKTLNKKVAQRAAQLQEALL 3306
             QD   + + +   ++  A        E   H +       K L   + +   + +  ++
Sbjct: 4754 LQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMV 4813

Query: 3307 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3366
                FQ  +   L W+   +  ++         + ++ +I++ ++ Q  +      +  +
Sbjct: 4814 QSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL 4873

Query: 3367 K-REGEKIATTAE--PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET 3423
              +E EK     E   AD    L +LS LD   +  L    TR   L  I    Q++++ 
Sbjct: 4874 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL---RTRQATLTEIYSQCQRYYQV 4930

Query: 3424 LEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK---ALEDDIINHNKHLHQAVSIGQ 3480
             +  N+WL   ++ L+     G      EE +  H    + ED   ++ + LH  V+   
Sbjct: 4931 FQAANDWLEDAQE-LLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 4989

Query: 3481 SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3540
             L   + +ED +   + L+        +   S ++ +LLQ+       + +   E++  +
Sbjct: 4990 PLIKPTGKEDLEQKVASLELRSQ---RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5046

Query: 3541 NEVHDKLSKLS-VQDYSTEGLWKQQSELRVL-------QEDILLRKQNVDQALLNGLELL 3592
            N+   KLS+ S ++  S+    ++ SE + L        E I+  ++   Q    G +  
Sbjct: 5047 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5106

Query: 3593 KQTTGDEVLIIQDKLEAIKARYKDITKLSTD-----------VAKTLEQALQLARRL--- 3638
            K T    +  +  +   ++A  +D  K+  D           V K  E   QL  +L   
Sbjct: 5107 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5166

Query: 3639 ---HSTHEELCTWLDKVEVELLSYETQ--------------------VLKGEE------- 3668
                ++  EL T L+  +  +L  E Q                       GEE       
Sbjct: 5167 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEI 5226

Query: 3669 ----------ASQAQMRPKELKKEAKNNKALLDSLN------------------EVSSAL 3700
                        + +   K +K+E K+ + +   +N                  E+ + L
Sbjct: 5227 TAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQL 5286

Query: 3701 LEL-----VPWRAREGLEKMVAEDNERYR-----LVSDTITQKVEEIDAAILRSQQFDQA 3750
             EL          R+ +EKM  E  E+Y      L S+   Q  E      +R Q  D+ 
Sbjct: 5287 EELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKI 5346

Query: 3751 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR----HKDIIDDLVKSG 3806
             + E S  T  E   +S    +L +D T+  L   K  T  +++     K + ++L    
Sbjct: 5347 KEVEQSKATSQE---LSRQIQKLAKDLTTI-LTKLKAKTDNVVQAKTDQKVLGEELDGCN 5402

Query: 3807 HKIMTACSEEEK---------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3857
             K+M   +  +K         + + KK+ K+ + +    +    R  +L +A S + ++ 
Sbjct: 5403 SKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYN 5462

Query: 3858 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3917
            E  E +  W+ E   +++           LR+Q   H+ L E   E    ++ M +    
Sbjct: 5463 EMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQY 5521

Query: 3918 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 3977
            L  +   E  S Q   +  +T   ++++ +K R   L +A     +F  ++ ++  +LE+
Sbjct: 5522 LTSVYCTEKMSQQVAELGRET--EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579

Query: 3978 IVERLRQPPSISAEVEK--IKEQISENKNVSVDMEKLQP------LYETLKQRGEEMIAR 4029
                L  P     EV +  +KEQ+S  +++  +ME L+P      L ++  +  E+++A 
Sbjct: 5580 AQATLTSP-----EVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVA- 5633

Query: 4030 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 4089
                    +A  +Q++  ++       HT +++       V++  E++  +   L   I+
Sbjct: 5634 --SLPLCHAALRLQEEASRLQ------HTAIQQCNIMQAAVVQY-EQYEQEMKHLQQLIE 5684

Query: 4090 DTQDFIRDLEDPGIDPSVVKQQQ---EAAETIREEIDGLQEELDIVINLGSELIAACGEP 4146
                  R++ED  +  S +++ Q      E + ++I G QE++  + +    L       
Sbjct: 5685 GAH---REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5741

Query: 4147 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG-LQAVFDWVDIAGGK-- 4203
               +    ++ L    + L+      +     A  + V    G    +   V    G+  
Sbjct: 5742 TMLLTVTEVEGLAEGTEDLD----GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEG 5797

Query: 4204 ----------LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN------HQAEL 4247
                        S SP+     +V Q I         AY Q +  ERL       H +  
Sbjct: 5798 TNSEISSPPACRSPSPVANTDASVNQDI---------AYYQALSAERLQTDAAKIHPSTS 5848

Query: 4248 LLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4307
              ++  E   + +    L +L+  W++L+  I  +Q  L  AL    ++Q +L  +   +
Sbjct: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908

Query: 4308 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV-EAVNKAGNDLIESSAGEE 4366
               E  LSE    G  P   E ++A+H  L +++L  Q  + E  +    +L+  S   +
Sbjct: 5909 EAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 5965

Query: 4367 ASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGAL-------RQAKG---FHGEIEDLQ 4413
             +    LQ+ L VL +R   +  K   ++Q L+  L       RQ +    +  E ++L 
Sbjct: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025

Query: 4414 QWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK 4473
             WL  T+  L  +      P   + QL     +    E K      L    + +L     
Sbjct: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085

Query: 4474 SAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI-------- 4522
              +   +Q    +  LK     ++  L++++  ++     A E   S  D          
Sbjct: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ---GTAQEKEESDVDLTATQSPGVQ 6142

Query: 4523 NWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4581
             WL QA  T     + SL     L Q + E K     V S  E+I+             +
Sbjct: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGE 6202

Query: 4582 KQDVVLIK--------NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ--FHEAWSKLM 4631
            K DV+  +        +    ++ +WE + Q    + + L +  ++ ++   +   ++L+
Sbjct: 6203 KPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLL 6262

Query: 4632 EWL--------EESEKSLDSELEIANDP-DKIKTQLAQHKEFQKSLGAKHSVYDTTNRT- 4681
              +         + + ++ S L+  N   +++ +Q    K  ++S+  +  +YD  + T 
Sbjct: 6263 SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK--RQSIHLEQKLYDGVSATS 6320

Query: 4682 -------------------------------GRSLKEKTSLADDNLKL--------DDML 4702
                                            + +KE +   D N  L         D  
Sbjct: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380

Query: 4703 SELRDKWDTICGK-----SVERQ------NKLEEALLFSGQFTDALQALIDWLYRVEPQL 4751
              + D    + G+     SV  Q       +L++ L F         +L D  Y +  +L
Sbjct: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6440

Query: 4752 AE--DQPVHGDIDLVMNLIDNHKAFQK---ELGKRTSSVQALKRSARELIEGSRDDSSWV 4806
            A   +QPV   I+ +    D  K F     EL +R   +Q  + S +EL           
Sbjct: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQEL----------- 6489

Query: 4807 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVL 4865
                 +L   ++ +  +  S+++ L   L    ++   +  L + L   ++ +     ++
Sbjct: 6490 ----SKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6545

Query: 4866 PDDEDALRTLIDQHKEFMKKLE 4887
               ++ ++ L+D+HKE+ + LE
Sbjct: 6546 VSSKEEIQQLLDKHKEYFQGLE 6567



 Score =  206 bits (525), Expect = 4e-52
 Identities = 145/440 (32%), Positives = 223/440 (50%), Gaps = 72/440 (16%)

Query: 24  DVLERYKDERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTL 81
           +V++R +DE++ VQK+TFTKWIN HL K +    V+DL+ED++DG  L++LLEVLSG  L
Sbjct: 16  NVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKL 75

Query: 82  PREKGRM--RFHRLQNVQIALDYLKRRQ-------VKLVNIRNDDITDGNPKLTLGLIWT 132
           P E+GR   R H + N+  AL +L+ R+       +KLVNI + DI DG P + LGL+WT
Sbjct: 76  PCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWT 135

Query: 133 IILHFQISDIH-------------------VTGESEDM------------SAKERLLLWT 161
           IIL+FQI ++                    V+ E+               +AK+ LL W 
Sbjct: 136 IILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWV 195

Query: 162 QQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE- 220
           Q       GI  ++F   WR G  F+++IH  RP+L+D+ TV  +SN  NLE AF +AE 
Sbjct: 196 QYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 255

Query: 221 KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNM 279
           ++G+ RLLDPEDVDV  PDEKS++TYV+     +P +     +G   +++   +  + N 
Sbjct: 256 ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANS 315

Query: 280 VNYLIQWIRHHVTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKR 333
           V    +  R     M       ER      +    L ++Y  FK   +      + K K+
Sbjct: 316 VQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQ 371

Query: 334 LYKLLEIWIEFGRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKA 375
           +  L++     G++ L Q       ++      +W            G +   +   E A
Sbjct: 372 IEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 431

Query: 376 LRPEVERLEMLQQIANRVQR 395
           LR E+   ++ ++ AN +QR
Sbjct: 432 LREEITVQQVHEETANTIQR 451



 Score =  159 bits (401), Expect = 9e-38
 Identities = 417/2207 (18%), Positives = 833/2207 (37%), Gaps = 317/2207 (14%)

Query: 1009 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1066
            L+  Q +    L+D +   +  S SD+     ++  C      ++ K   R E     + 
Sbjct: 6668 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6727

Query: 1067 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1126
             Y SE  ++   L++ +DRL                 F   +   + +ELE ++D L   
Sbjct: 6728 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6771

Query: 1127 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1171
                +E  +Q++  SSV                TLRSEL+ +      + +      +KL
Sbjct: 6772 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6831

Query: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1222
                L +    +  A+ ++       E  +  D++NI+N I            K ++ ++
Sbjct: 6832 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6889

Query: 1223 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1282
            + K+     +    Q    IS +  ++ +    DF    E+   + + WQ +   +  ++
Sbjct: 6890 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 6943

Query: 1283 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1342
            + LEG+ +S   Y +    L  W +  E  +R  Q+++  +  ++   L   + L   I+
Sbjct: 6944 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7001

Query: 1343 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1402
             K+ ++++ ++         K+ ++ ++    + +  Q +      M     ++++  +D
Sbjct: 7002 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7059

Query: 1403 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1462
              + +      +  Y+  A  SL R      SLE            +Q  V N+     D
Sbjct: 7060 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7108

Query: 1463 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1522
             EK  +   S QK  S      KE      +T                   L   +K + 
Sbjct: 7109 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7146

Query: 1523 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1582
              +N L  E  +QLQ S          K + +  Q YK+  +     + Q E+R      
Sbjct: 7147 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7190

Query: 1583 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1636
                   T EL K  + ++    ++    Q   ++      VK++  FL E GE+L Q+ 
Sbjct: 7191 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243

Query: 1637 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1696
             A     +   ++   Q     EQ+            K++T   A V   E     +E L
Sbjct: 7244 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7293

Query: 1697 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1756
              W+   ++  +     H                                      + T 
Sbjct: 7294 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7318

Query: 1757 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1816
            QE +    +++K Q  K  S    +          L + G  L   +KE   K M+ L  
Sbjct: 7319 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7364

Query: 1817 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1876
            H+    +++ ++     S   + + F      +  +L Q+EQ+L    +G  +   L+ +
Sbjct: 7365 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7422

Query: 1877 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1936
             +  + F  ++ S +  L  I I G R+LE          G+VD      E   KL   +
Sbjct: 7423 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7470

Query: 1937 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 1995
            ++++ +  +       +   + ++Q Y + +  L   L          L S PI +    
Sbjct: 7471 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7530

Query: 1996 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2052
                + Q +E   L+ Q  S  + VE  K   ++LL A      A+  +Q  L +I  ++
Sbjct: 7531 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7583

Query: 2053 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2112
            +  S  + E+ +KL   L      + G+ + L+ +   +  L +   +P +   L     
Sbjct: 7584 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7641

Query: 2113 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2172
            +   LE  +      +  ++               S L  +++ L  ++ E  H   +  
Sbjct: 7642 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7698

Query: 2173 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2227
             + +++  ++  +   SEK +   E  TQ  ++V   G  + E     L +  QE  +  
Sbjct: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7758

Query: 2228 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2286
             E+K  L+ +   L + S     S+    L K N+  +   ++    +K+ KE + + Q 
Sbjct: 7759 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7817

Query: 2287 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2344
            QLD     + SL++W+     ++  PIV  S  +E++ + L + ++LQ        +I+K
Sbjct: 7818 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7867

Query: 2345 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2404
             +    S+ NL   +     A A               T+ E         SI++   ++
Sbjct: 7868 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7905

Query: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2464
               + ++  +  ++  ++       QK  ++ S    WL+   +TA  +  +     T A
Sbjct: 7906 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 7964

Query: 2465 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2524
             K ++++ ++F+ ++ + + +++ +  +   L  EN  T  A   KQM+ E + +W  L 
Sbjct: 7965 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8022

Query: 2525 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2584
            +      ++L+       +F+T    +  WL E +L ++ +   S     +  + +Q++ 
Sbjct: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD--VQAKIKQLKA 8080

Query: 2585 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2644
              QE +    + EQ+ A G+ ++ +   +P    I++E+L  + +    + G++      
Sbjct: 8081 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8138

Query: 2645 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2700
            + +  +   ++    R L    S  LSDL     S+ ++ +   + N  L  AQ ++ E 
Sbjct: 8139 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8198

Query: 2701 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKD------------ 2743
                    V     E     DLS  ++    +A  S   EG  +  KD            
Sbjct: 8199 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSDV 8256

Query: 2744 -VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLD 2794
             + +  E +V+  ++A         A   Q +Q+ +      D++ + Q   + I +K  
Sbjct: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQIQQTENIIRSKTP 8313

Query: 2795 VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----N 2849
                L   +K + K L   S   + ++   E+ L + + S    + L     +T      
Sbjct: 8314 TGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDR 8372

Query: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGEN 2906
            W+    Q   +E ++K++L+K  ++   + ++W W+   +  LE+   ++   D    E 
Sbjct: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432

Query: 2907 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 2966
             I KLK LQK +D    ++  +N  +         +   + D    +  + D V   L  
Sbjct: 8433 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 8492

Query: 2967 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3026
             +  L++   + + F E+S      L    E +D   +      SN    +LQ   K L 
Sbjct: 8493 WRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548

Query: 3027 ALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFL 3080
             +KH++    L     QD+  +   +++GT   +   +V  I      L ++V      L
Sbjct: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 8608

Query: 3081 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 3123
            E KL  +   Q  +    S      DELD+   V    GR     QK
Sbjct: 8609 E-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 8649


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score =  312 bits (800), Expect = 5e-84
 Identities = 181/404 (44%), Positives = 248/404 (61%), Gaps = 15/404 (3%)

Query: 31  DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGRMR 89
           DER+ VQKKTFTKW+N HL +V   V DLY DLRDG NL+ LLEVLSG+ LP+  KGRMR
Sbjct: 53  DEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMR 112

Query: 90  FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGES- 148
            H L+NV  AL +LK ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V  E  
Sbjct: 113 IHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDN 172

Query: 149 -EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQS 207
            E  SAK+ LLLW Q  T GY  +   NFTT WRDG  FNAI+HK+RPDL+D  ++   +
Sbjct: 173 KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCN 232

Query: 208 NLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GGEG 263
              NL++AF +AEK +G+ +LLDPEDV+V  PDEKS+ITYV++ Y  F K+      G+ 
Sbjct: 233 AHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKR 292

Query: 264 IG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 318
           IG     A + E    +Y+++ + L+QWI   + T+++R   N+   ++     +  ++ 
Sbjct: 293 IGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRT 352

Query: 319 TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKA 375
            E PPK TEK  ++ L   ++  +     K+    +G   +DI K W +L  A  ERE A
Sbjct: 353 VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELA 412

Query: 376 LRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLE 419
           LR E+ R E L+Q+A R  R + + E  L      +  D+  LE
Sbjct: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLE 456



 Score =  159 bits (403), Expect = 6e-38
 Identities = 343/1769 (19%), Positives = 687/1769 (38%), Gaps = 166/1769 (9%)

Query: 3292 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL 3351
            K++ +      EA     +++     LL W+  T  +  N +  +     V+ Q+Q    
Sbjct: 291  KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTI-VTLNDRQLANSLSGVQNQLQSFNS 349

Query: 3352 LQRLLDDRKST----VEVI--------KREGEKIATTAEP---ADKVKILKQLSLLDSRW 3396
             + +    K T    +EV+        +   +K+ T  E    +D  K  ++L   +   
Sbjct: 350  YRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHER 409

Query: 3397 EALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIA 3456
            E  L     R  +LE +   A +F         WL+   +RLV+ +  G + + +E  + 
Sbjct: 410  ELALRTELIRQEKLEQL---AARFDRKAAMRETWLSE-NQRLVSQDNFGLELAAVEAAVR 465

Query: 3457 QHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRS 3516
            +H+A+E DI+ ++  +    ++   L      + K +   + + +++W   +++   +R 
Sbjct: 466  KHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDF-LRQMVAARR 524

Query: 3517 ELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILL 3576
            E L   L   K+F +D + LM+W+ E+  +L    +  +   G+        +++ DI +
Sbjct: 525  ERLLLNLELQKVF-QDLLYLMDWMEEMKGRLQSQDLGRHLA-GVEDLLQLHELVEADIAV 582

Query: 3577 RKQNVDQALLNGLELL---KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3633
            + + V     + L      K+    +  ++ +++  ++  Y+ + +L+      LE++ +
Sbjct: 583  QAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRR 642

Query: 3634 LARRLHSTHEELCTWLDKVEVELLSYET--------QVLKGEEASQAQM--RPKELKKEA 3683
            L R L    E    W+ + +  L S +T        ++L    A + +M  R   LK   
Sbjct: 643  LWRFLWEVGEAEA-WVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTL 701

Query: 3684 KNNKALL----DSLNEVSSALLEL-VPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3738
            +  + L+       ++ S+   EL   W   E LE +  E  +R                
Sbjct: 702  EQGQQLVAEGHPGASQASARAAELQAQW---ERLEALAEERAQRLA-------------Q 745

Query: 3739 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDI 3798
            AA L   Q D A D E +W+ +   +L+S  ++  ++  T A  +  +    EI  H+  
Sbjct: 746  AASLYQFQAD-ANDME-AWLVDA-LRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPT 802

Query: 3799 IDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWE 3858
            +D L +    +    S   +  ++ ++  + ++Y+ +     ER   LE A +L     E
Sbjct: 803  LDALREQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSE 860

Query: 3859 TYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQL 3918
                   W+ E +  ++ L  P    E L   Q+    L   +      I  +N    QL
Sbjct: 861  A-GACGLWVEEKEQWLNGLALPE-RLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQL 918

Query: 3919 LELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI---LESL 3975
            L+ +P     I       +  + Q +     +  AL  A+S    +H +  +    +   
Sbjct: 919  LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQN-YHLECTETQAWMREK 977

Query: 3976 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4035
             +++E  +   +  A V  ++ +++  +    D+E +      L +    + A       
Sbjct: 978  TKVIESTQGLGNDLAGVLALQRKLAGTER---DLEAIAARVGELTREANALAA-----GH 1029

Query: 4036 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4095
               A A+  +L ++   WE++   +  RE  L +   L + F          +  TQ  +
Sbjct: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQD-FLRSLDDFQAWLGRTQTAV 1088

Query: 4096 RDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSI 4155
               E P   P       + A  +R E++  Q E   +  LG E+     +P    +++ +
Sbjct: 1089 ASEEGPATLPEAEALLAQHA-ALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147

Query: 4156 DELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4215
            + L + W+ L + W+ R  +L +A       +D  QA  + V  +   + S + +   L+
Sbjct: 1148 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQA--EGVLSSQEYVLSHTEMPGTLQ 1205

Query: 4216 TVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSL 4275
                 I++L+ F S        +  L      L+ +    +DK         ++   DS+
Sbjct: 1206 AADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK---------IREKADSI 1256

Query: 4276 EERIINRQHKLE---GALLALGQFQHALD---ELLAWLTHTEGLLSEQKPVGGDPKAIEI 4329
            E R    Q   +   G L    + QH L    EL  W+   E +L+ Q     + + +  
Sbjct: 1257 ERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWI--DEKMLTAQDVSYDEARNLHT 1314

Query: 4330 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4389
            +  KH     ++ A++  ++ V+K G +L      E  + +  KL  L++RW   LE T 
Sbjct: 1315 KWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP-ELKALVSEKLRDLHRRWDE-LETTT 1372

Query: 4390 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVHMEV 4446
            Q K +      +A+ F      L+ WL   +  L +    K L  +    K+Q  +  E+
Sbjct: 1373 QAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEM 1432

Query: 4447 CA---AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4503
                   EA +   K+L Q+ Q             +++    ++EK+ ++   + ER  +
Sbjct: 1433 AVREKEVEAIQAQAKALAQEDQ---------GAGEVERTSRAVEEKFRALCQPMRERCRR 1483

Query: 4504 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4563
            L +A     +FH  ++D I W+T+    +  +      L +V   + +++    E+  H 
Sbjct: 1484 L-QASREQHQFHRDVEDEILWVTE-RLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHE 1541

Query: 4564 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4623
             +I +L +    L   +   +       L  +Q  W+++   L  RG+ L+DA  RA+QF
Sbjct: 1542 PRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRGKRLEDA-LRAQQF 1593

Query: 4624 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4683
            +   ++   W+ E E  +  + E A D    + ++ +H+  +++L            + +
Sbjct: 1594 YRDAAEAEAWMGEQELHMMGQ-EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQ 1652

Query: 4684 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQ 4738
             +      E T ++    ++D + + L++    + G   ER+ +L+E L    Q    L 
Sbjct: 1653 DMIDHEHPESTRISIRQAQVDKLYAGLKE----LAG---ERRERLQEHLRLC-QLRRELD 1704

Query: 4739 ALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELG----KRTSSVQALKRSARE 4794
             L  W+   E  +A    +  D + V  L D  + F ++      +R  S  AL   A  
Sbjct: 1705 DLEQWIQERE-VVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANAL---ANG 1760

Query: 4795 LIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAE 4854
            LI G     + V      L+  W  +  L  ++   L AA       H    AL     +
Sbjct: 1761 LIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHK 1820

Query: 4855 AEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPD 4910
             +Q       LPD    D +A   L  +H  +   ++    ++ +    G  +      D
Sbjct: 1821 QQQ-------LPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGD 1873

Query: 4911 SITTIKHWITIIRARFEEVLAWAKQHQQRLA--SALAGLIAKQELLEALLAWLQWAETTL 4968
                I   +  +        AWA+      A    L     K    +A+   + W +   
Sbjct: 1874 KAEEIGRHMQAVAE------AWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVN 1927

Query: 4969 TDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997
               D +  P+++     +I   Q    E+
Sbjct: 1928 LQMDAQERPRDVSSADLVIKNQQGIKAEI 1956



 Score =  137 bits (346), Expect = 2e-31
 Identities = 334/1869 (17%), Positives = 710/1869 (37%), Gaps = 224/1869 (11%)

Query: 3174 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3233
            K+  K+LD A   E  VE       E    +++  + L    + + +    G++ +   Q
Sbjct: 291  KRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLN---DRQLANSLSGVQNQL--Q 345

Query: 3234 QLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK 3293
              N ++  +K      +G  + + +  Q  +++  +   T      + D+N  W+ L K 
Sbjct: 346  SFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKA 405

Query: 3294 VAQRAAQLQEALLH-------CGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQI 3346
              +R   L+  L+          RF        +W+ + + LV +Q     E   V+A +
Sbjct: 406  EHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLV-SQDNFGLELAAVEAAV 464

Query: 3347 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSRWEALLNKAET 3405
            ++ + ++  +      V+ +     ++A  AE    +K I  +   +   W+ L      
Sbjct: 465  RKHEAIETDIVAYSGRVQAVDAVAAELA--AERYHDIKRIAARQHNVARLWDFLRQMVAA 522

Query: 3406 RNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDI 3465
            R  +L  +++  Q+  + L  L +W+  ++ RL   + +G   + +E+ +  H+ +E DI
Sbjct: 523  RRERLL-LNLELQKVFQDLLYLMDWMEEMKGRL-QSQDLGRHLAGVEDLLQLHELVEADI 580

Query: 3466 INHNKHLHQAVSIGQSLKVLSSRE----DKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3521
                + + +AVS          +E    D  +V  ++   +  Y  + E + +R   L++
Sbjct: 581  AVQAERV-RAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEE 639

Query: 3522 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3581
            +    +   E   E   W+ E    L+        T         LR+L +   LR +  
Sbjct: 640  SRRLWRFLWE-VGEAEAWVREQQHLLASADTGRDLT-------GALRLLNKHTALRGE-- 689

Query: 3582 DQALLNGLELLKQTTGDEVLIIQD----------KLEAIKARYKDITKLSTDVAKTLEQA 3631
               +   L  LK T      ++ +          +   ++A+++ +  L+ + A+ L QA
Sbjct: 690  ---MSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746

Query: 3632 LQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAKNNKALL 3690
              L  +  +   ++  WL  V+   L    ++   E ++QA  R  + L++E ++++  L
Sbjct: 747  ASL-YQFQADANDMEAWL--VDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTL 803

Query: 3691 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3750
            D+L E ++AL   +  R  E ++  V      Y  +     ++   ++AA+       +A
Sbjct: 804  DALREQAAALPPTLS-RTPE-VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEA 861

Query: 3751 ADAELSWITETEKKLMSLG------DIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVK 3804
                L W+ E E+ L  L       D+ + Q +         T   +I    DI + L+K
Sbjct: 862  GACGL-WVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLK 920

Query: 3805 SGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELW 3864
            +        +   K  +    +++   +    ++   +   L  A S+ N   E   E  
Sbjct: 921  A--------NPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC-TETQ 971

Query: 3865 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
             W+ E   +I        +   +   Q +       +      + ++ +    L    P 
Sbjct: 972  AWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPA 1031

Query: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERL-- 3982
            +  +I  +     T +  ++  +++R  +L EA  +   F   +D     L R    +  
Sbjct: 1032 QAVAINARLREVQTGWEDLRATMRRREESLGEA-RRLQDFLRSLDDFQAWLGRTQTAVAS 1090

Query: 3983 RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042
             + P+   E E +   ++++  +  ++E+ Q  Y  L+  GEE+         D     +
Sbjct: 1091 EEGPATLPEAEAL---LAQHAALRGEVERAQSEYSRLRALGEEVTR----DQADPQCLFL 1143

Query: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDV---------------MELAEKFWCDHMSLIVT 4087
            + +L+ +   WE +  + E R+ +L                  +  ++++   H  +  T
Sbjct: 1144 RQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGT 1203

Query: 4088 -------IKDTQDFIRDLEDPG--------IDPSVVKQQQEAAETIREEIDGLQEELDIV 4132
                   IK  +DF+  ++  G            +V +    A+ IRE+ D ++      
Sbjct: 1204 LQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKN 1263

Query: 4133 INLGSELIAACGE--------PDKPIVKKSIDE---------------LNSAWD------ 4163
             +   + +    +         D   +K  IDE               L++ W       
Sbjct: 1264 QDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFM 1323

Query: 4164 ---SLNKAWKDRIDK-----------------------------LEEAMQA--------- 4182
               + NK W D++DK                             LE   QA         
Sbjct: 1324 AELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDAN 1383

Query: 4183 -AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERL 4241
             A  +     A+  W++    +L S    G DL +V   +++ +  + E   ++ E+E +
Sbjct: 1384 RAELFAQSCCALESWLESLQAQLHS-DDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAI 1442

Query: 4242 NHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALD 4301
              QA+ L +   E+     V+     ++  + +L + +  R  +L+ A     QF   ++
Sbjct: 1443 QAQAKALAQ---EDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ-ASREQHQFHRDVE 1498

Query: 4302 ELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIES 4361
            + + W+T    + S  +  G D  ++++ + K+  LQ ++  H+  +  + +    L  +
Sbjct: 1499 DEILWVTERLPMASSMEH-GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAA 1557

Query: 4362 SAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER 4421
            +AG E + LQ       + W+ +  + E R ++L+ ALR A+ F+ +  + + W+ + E 
Sbjct: 1558 AAGPELAELQ-------EMWKRLGHELELRGKRLEDALR-AQQFYRDAAEAEAWMGEQEL 1609

Query: 4422 HLLASKPLGGLPETAKEQLNVHMEVC------AAFEAKEETYKSLMQKGQQML-ARCPKS 4474
            H++         E AK++L+   EV        A     +T   L    Q M+    P+S
Sbjct: 1610 HMMGQ-------EKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPES 1662

Query: 4475 AETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNV 4534
               +I Q    + + +  ++    ER+ +L+E L L  +    L D   W+ Q  + +  
Sbjct: 1663 TRISIRQ--AQVDKLYAGLKELAGERRERLQEHLRLC-QLRRELDDLEQWI-QEREVVAA 1718

Query: 4535 ASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLIS 4594
            +       + V    D+ + F+ + ++  ++ ++      +            +     S
Sbjct: 1719 SHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDS 1778

Query: 4595 VQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4654
            +   W  +++ L  RG+ L  A +  +  H A   L     + ++  D       D +  
Sbjct: 1779 LNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDG---TGRDLNAA 1835

Query: 4655 KTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICG 4714
            +    +H  ++  + A           G  L +K    D   ++   +  + + W  + G
Sbjct: 1836 EALQRRHCAYEHDIQALSPQVQQVQDDGHRL-QKAYAGDKAEEIGRHMQAVAEAWAQLQG 1894

Query: 4715 KSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL-AEDQPVHGDIDLVMNLIDNHKA 4773
             S  R+  L +      +F  A++ L+ W+  V  Q+ A+++P   D+     +I N + 
Sbjct: 1895 SSAARRQLLLDT-TDKFRFFKAVRELMLWMDEVNLQMDAQERP--RDVSSADLVIKNQQG 1951

Query: 4774 FQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEA 4833
             + E+  R     +     +EL+  S   +  +  ++ +L  R +        K   L+ 
Sbjct: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQL 2011

Query: 4834 ALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKR 4890
             L +   F         WL   E  +R    L    D + +LI +H+ F K     EE+ 
Sbjct: 2012 VL-EVLVFGRDAGMAEAWLCSQEPLVR-SAELGCTVDEVESLIKRHEAFQKSAVAWEERF 2069

Query: 4891 AELNKATTM 4899
              L K T +
Sbjct: 2070 CALEKLTAL 2078



 Score =  118 bits (296), Expect = 1e-25
 Identities = 204/1007 (20%), Positives = 402/1007 (39%), Gaps = 89/1007 (8%)

Query: 4053 WENIHTLVEEREAKLLDVM-------ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDP 4105
            WE +     ERE  L   +       +LA +F          + + Q  +   ++ G++ 
Sbjct: 399  WERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQ-DNFGLEL 457

Query: 4106 SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSL 4165
            + V+      E I  +I      +  V  + +EL A      K I  +    +   WD L
Sbjct: 458  AAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQ-HNVARLWDFL 516

Query: 4166 NKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELK 4225
             +    R ++L   ++    +QD L  + DW++   G+L S   +G  L  V+  ++  +
Sbjct: 517  RQMVAARRERLLLNLELQKVFQD-LLYLMDWMEEMKGRLQSQD-LGRHLAGVEDLLQLHE 574

Query: 4226 QFKSEAYQQQIEMERLNHQAELLLK-----KVTEESDKHTVQDPLMELKLIWDSLEERII 4280
              +++     ++ ER+   +   L+     K     D   V + + +L+  +++L E   
Sbjct: 575  LVEADI---AVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631

Query: 4281 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQND 4340
             R+ +LE +   L +F   + E  AW+   + LL+     G D       L KH  L+ +
Sbjct: 632  ARRARLEESR-RLWRFLWEVGEAEAWVREQQHLLASAD-TGRDLTGALRLLNKHTALRGE 689

Query: 4341 VLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4400
            +      ++   + G  L+ +     AS    +   L  +W+ +    E+R Q+L  A  
Sbjct: 690  MSGRLGPLKLTLEQGQQLV-AEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAAS 748

Query: 4401 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4460
              + F  +  D++ WL D  R L++S  LG    + +     H  +     +   T  +L
Sbjct: 749  LYQ-FQADANDMEAWLVDALR-LVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDAL 806

Query: 4461 MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD 4520
             ++   +     ++ E  +   +  L+  +E ++ +  ER   LE AL L      +   
Sbjct: 807  REQAAALPPTLSRTPE--VQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGAC 864

Query: 4521 FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHL-KYF 4579
             + W+ + EQ LN  + P  + D  + Q    +    E+N+   QI  ++     L K  
Sbjct: 865  GL-WVEEKEQWLNGLALPERLEDLEVVQ-QRFETLEPEMNTLAAQITAVNDIAEQLLKAN 922

Query: 4580 SQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEK 4639
               +D ++  N    +  RW++  +RL +  ++   +    + +H   ++   W+ E  K
Sbjct: 923  PPGKDRIV--NTQEQLNHRWQQF-RRLADGKKAALTSALSIQNYHLECTETQAWMREKTK 979

Query: 4640 SLDSELEIANDPDKIKTQLAQHKEFQKSL-GAKHSVYDTTNRTGRSLKEKTSLADDN--- 4695
             ++S   + ND       LA     Q+ L G +  +     R G   +E  +LA  +   
Sbjct: 980  VIESTQGLGND-------LAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQ 1032

Query: 4696 -LKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALID---WLYRVEPQL 4751
             + ++  L E++  W+ +      R+  L EA     +  D L++L D   WL R +  +
Sbjct: 1033 AVAINARLREVQTGWEDLRATMRRREESLGEAR----RLQDFLRSLDDFQAWLGRTQTAV 1088

Query: 4752 AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WVKVQM 4810
            A ++     +     L+  H A + E+ +  S    L+    E+     D    +++ ++
Sbjct: 1089 ASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147

Query: 4811 QELSTRWETVCALSISKQTRLEAA------LRQAEEFHSVVHALLEWLAEAEQTLRFHGV 4864
            + L T WE +  +  S+Q RL  A      LR A +   V+         +++ +  H  
Sbjct: 1148 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVL--------SSQEYVLSHTE 1199

Query: 4865 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAI--CHPDSITTIKHWITII 4922
            +P    A    I + ++FM  ++     ++     G  +++    H D I          
Sbjct: 1200 MPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKI---------- 1249

Query: 4923 RARFEEVLAWAKQHQ---QRLASALAGLIAKQELLE---ALLAWLQWAETTLTDKDKEVI 4976
            R + + +    K++Q   Q+    L     +Q  L+    L  W+   E  LT +D  V 
Sbjct: 1250 REKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWID--EKMLTAQD--VS 1305

Query: 4977 PQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5023
              E   +     +HQ FM E+   +  +DKV K  +    +   L++
Sbjct: 1306 YDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKA 1352



 Score =  110 bits (275), Expect = 4e-23
 Identities = 360/1904 (18%), Positives = 717/1904 (37%), Gaps = 276/1904 (14%)

Query: 2021 KKTAEVLLDARGSLLPAKNDIQKT------LDDIVGRYEDLSKSVNERNEKLQITLTRSL 2074
            K   EVLL    S L A N    T      + DI   +E L K+ +ER   L+  L R  
Sbjct: 362  KGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQE 421

Query: 2075 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2128
             ++      D    M +   +    L  Q    L   A++  + K+  +E DI      +
Sbjct: 422  KLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRV 481

Query: 2129 NAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHK----HKETLAKMEELKTKVEL 2184
             A++    +         A+     +K ++AR    +       +   A+ E L   +EL
Sbjct: 482  QAVDAVAAEL--------AAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLEL 533

Query: 2185 ---FENLSEKLQTFLETK----TQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVL 2237
               F++L   +    E K    +Q L       +D+ +L + ++   +   E  + +   
Sbjct: 534  QKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSAS 593

Query: 2238 HSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKS 2297
                        P D  LV E+   L + ++ + +    ++  +   + +L  F   V  
Sbjct: 594  ALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESR-RLWRFLWEVGE 652

Query: 2298 LKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLIS 2357
             ++W++E        Q    + D G+ L    +L  K +    E+              S
Sbjct: 653  AEAWVREQ-------QHLLASADTGRDLTGALRLLNKHTALRGEM--------------S 691

Query: 2358 AVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKD 2417
                P K        G  L  EG          + G +       ++   +E L  L ++
Sbjct: 692  GRLGPLKLTL---EQGQQLVAEG----------HPGASQASARAAELQAQWERLEALAEE 738

Query: 2418 KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEA 2477
            +   L  + + L + Q +++ M  WL    +  +  +       T+A+     Q+++ E 
Sbjct: 739  RAQRL-AQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL---ARQHRALEE 794

Query: 2478 ELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEES 2537
            E++ +   +  L+++   L      TPE    +  +  ++  ++EL     +R + LE +
Sbjct: 795  EIRSHRPTLDALREQAAALPPTLSRTPEV---QGRVPTLERHYEELQARAGERARALEAA 851

Query: 2538 SNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYE 2597
                T      A    W+ EKE  ++ L         L  + + ++++ Q F T +P+  
Sbjct: 852  LALYTMLSEAGA-CGLWVEEKEQWLNGLA--------LPERLEDLEVVQQRFETLEPEMN 902

Query: 2598 QLTAAGQGI---------LSRPGEDPSLRGIVKEQLAAVTQKWD--------SLTGQLSD 2640
             L A    +          + PG+D  +    +EQL    Q++         +LT  LS 
Sbjct: 903  TLAAQITAVNDIAEQLLKANPPGKDRIVN--TQEQLNHRWQQFRRLADGKKAALTSALS- 959

Query: 2641 RCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMK 2697
                I    ++ T+ Q+ +R  +   +    L N L+  LA+        + LE      
Sbjct: 960  ----IQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARV 1015

Query: 2698 QEIQQEKKQIKV---AQALCEDLSALVKE-----EYLKAELSRQLEGILKSFKDVEQKAE 2749
             E+ +E   +     AQA+   ++A ++E     E L+A + R+ E +            
Sbjct: 1016 GELTREANALAAGHPAQAVA--INARLREVQTGWEDLRATMRRREESL------------ 1061

Query: 2750 NHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKT 2809
               + LQ        F +   DFQAWL  + +    S    A L   E+L+  H      
Sbjct: 1062 GEARRLQD-------FLRSLDDFQAWLG-RTQTAVASEEGPATLPEAEALLAQHAALRGE 1113

Query: 2810 LTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES-- 2867
            +      Y +  A GE +       +   L+ +L  + T W+   +  + R+ +L ++  
Sbjct: 1114 VERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHG 1173

Query: 2868 LEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVEL 2927
             +  L+   Q E +          L   ++ L   E   ++    +  K+++     ++ 
Sbjct: 1174 FQGFLRDARQAEGV----------LSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDA 1223

Query: 2928 LNNTANSLLSVCEIDKEVVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEV 2984
                 + LL   E  +++V++ N     + +K D + E+ H K    ++  Q+F      
Sbjct: 1224 NGERIHGLL---EAGRQLVSEGNIHADKIREKADSI-ERRHKKN---QDAAQQFLGRLRD 1276

Query: 2985 SKESKRQLQ-CAKEQLDIHDS-LGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 3042
            ++E +  LQ C + +L I +  L +Q  S      L T+ +     KHQ  +A+  A   
Sbjct: 1277 NREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQ-----KHQAFMAELAANKD 1331

Query: 3043 VVEASDSKGTSDVLLQVE---TIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3099
             ++  D +G    L + E    ++++   L ++ DE    LET  Q         R +F 
Sbjct: 1332 WLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDE----LETTTQA------KARSLFD 1381

Query: 3100 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3159
                              AE   +    ++++L+ L+A + S+D       + +  ++  
Sbjct: 1382 ---------------ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQ 1426

Query: 3160 P---DLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL----KEFSILLQ 3212
                ++   ++++EA+  Q   L    Q   E VE T + +EE +  L    +E    LQ
Sbjct: 1427 MLEWEMAVREKEVEAIQAQAKALAQEDQGAGE-VERTSRAVEEKFRALCQPMRERCRRLQ 1485

Query: 3213 KAEEHEESQGPVGMETETINQQLNMFKVFQK----EEIEPLQGKQQDVNWLGQGL----- 3263
             + E  +    V  E   + ++L M    +       ++ L  K Q +    QG      
Sbjct: 1486 ASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIA 1545

Query: 3264 -IQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM 3322
             ++   ++        +L ++   WK L  ++  R  +L++AL     ++DA E+  +WM
Sbjct: 1546 DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAWM 1604

Query: 3323 VDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADK 3382
             + E  +  Q+    E    +A++++ ++L++ L D   T+  +    + +     P + 
Sbjct: 1605 GEQELHMMGQEKAKDELS-AQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHP-ES 1662

Query: 3383 VKILKQLSLLDSRWEALLNKA-ETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLV-- 3439
             +I  + + +D  +  L   A E R R  E + +   Q    L+ L +W+   E+ +V  
Sbjct: 1663 TRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC--QLRRELDDLEQWIQ--EREVVAA 1718

Query: 3440 ------NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDM 3493
                  + E +     K  E       +  + ++    L   +  G      +  E KD 
Sbjct: 1719 SHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKD- 1777

Query: 3494 VQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLS-V 3552
                   ++ W  ++ E   +R ++L  A            EL  +L+     L+++   
Sbjct: 1778 -----SLNEAW-ADLLELLDTRGQVLAAA-----------YELQRFLHGARQALARVQHK 1820

Query: 3553 QDYSTEGLWKQQSELRVLQ-------EDILLRKQNVDQALLNGLELLKQTTGDEVLIIQD 3605
            Q    +G  +  +    LQ        DI      V Q   +G  L K   GD+   I  
Sbjct: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880

Query: 3606 KLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLK 3665
             ++A+   +  +   S    + L       R   +   EL  W+D+V +++ + E    +
Sbjct: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAV-RELMLWMDEVNLQMDAQE----R 1935

Query: 3666 GEEASQAQMRPKE---LKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNER 3722
              + S A +  K    +K E +       S  ++   LL    + A E  EK+      R
Sbjct: 1936 PRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR 1995

Query: 3723 YRLVSDTITQKVEEID--AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSA 3780
                 +T  +  E++D    +L    F + A    +W+  +++ L+   ++    D+  +
Sbjct: 1996 ----QETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLC-SQEPLVRSAELGCTVDEVES 2050

Query: 3781 QLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 3824
             ++  + F    +  ++    L K     +TA  E EK+  +K+
Sbjct: 2051 LIKRHEAFQKSAVAWEERFCALEK-----LTALEEREKERKRKR 2089



 Score =  108 bits (269), Expect = 2e-22
 Identities = 343/1970 (17%), Positives = 756/1970 (38%), Gaps = 251/1970 (12%)

Query: 1426 KRLEEEEKSLEE-EKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1484
            K L+ E+ ++++ ++K  +        + S +     + ++ GK       + +E +  K
Sbjct: 252  KLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGK--VLDHAMEAERLVEK 309

Query: 1485 KEQL-SEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1543
             E L SE LQ I+  +    D+      + ++ Q+++   SY      ++++  +    G
Sbjct: 310  YESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFN-SYR-----TVEKPPKFTEKG 363

Query: 1544 DVKV-----EEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQS 1598
            +++V     + K+ A  Q+ Y           T  E RLI       I      L+K + 
Sbjct: 364  NLEVLLFTIQSKLRANNQKVY-----------TPREGRLISD-----INKAWERLEKAEH 407

Query: 1599 KQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKC 1651
            ++E     EL  Q+ ++  A          E +L EN   +SQ++  L    +  A  K 
Sbjct: 408  ERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKH 467

Query: 1652 EQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAG 1711
            E +          +  V   A +   E+   +K++   +  +  L D+L       +   
Sbjct: 468  EAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFL------RQMVA 521

Query: 1712 TKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQH 1771
             + ++++          D    +   +E+ G L   D+ G+     E+L Q ++ V+A  
Sbjct: 522  ARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDL-GRHLAGVEDLLQLHELVEAD- 579

Query: 1772 EKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKL 1831
               I+     + A  ++ +     G+   P + + + + + +L+  YE AL E     + 
Sbjct: 580  ---IAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYE-ALCELAAARRA 635

Query: 1832 THSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHK 1891
                   L +F  +  E E W+++ +  L + + G  D+ G +  L +  +   ++    
Sbjct: 636  RLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGR-DLTGALRLLNKHTALRGEMSGRL 694

Query: 1892 GDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGN 1951
            G L+     G +++      ++   G    SA   E+Q        ++  L +       
Sbjct: 695  GPLKLTLEQGQQLV------AEGHPGASQASARAAELQA-------QWERLEALAEERAQ 741

Query: 1952 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP-IAVDPKNLQRQLEETKALQGQI 2010
             L      YQ   DA+      ++A    A + +S P +  D  + Q    + +AL+ +I
Sbjct: 742  RLAQAASLYQFQADAN-----DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEI 796

Query: 2011 SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2070
             S +  ++ L++ A  L       L    ++Q  +  +   YE+L     ER   L+  L
Sbjct: 797  RSHRPTLDALREQAAAL----PPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAAL 852

Query: 2071 TRSLSVQDG------LDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGR 2124
                 + +       ++E   W+  +         +P     L+ +  +   LE ++   
Sbjct: 853  ALYTMLSEAGACGLWVEEKEQWLNGL--------ALPERLEDLEVVQQRFETLEPEMNTL 904

Query: 2125 QSSINAMNEKVKKFMETTDP--STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2182
             + I A+N+  ++ ++   P      + Q ++     +F   +   K  L         +
Sbjct: 905  AAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTS----ALSI 960

Query: 2183 ELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLK 2242
            + +     + Q ++  KT+ +      G D+  +    ++        ++ LE + + + 
Sbjct: 961  QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGT----ERDLEAIAARVG 1016

Query: 2243 EIS------SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVK 2296
            E++      + G P+    +  +   +   ++++  T++ ++E++   + +L  F   + 
Sbjct: 1017 ELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLD 1075

Query: 2297 SLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLI 2356
              ++W+  T       Q +  +E+   +L + + L  + +    E+++  +    L  L 
Sbjct: 1076 DFQAWLGRT-------QTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALG 1128

Query: 2357 SAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLK 2416
              VT                             A+     +++ +  +  G+E+LG + +
Sbjct: 1129 EEVTRDQ--------------------------ADPQCLFLRQRLEALGTGWEELGRMWE 1162

Query: 2417 D---KIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2473
                ++A+ +     L+ A++    +      ++        T  P   +A    +++ +
Sbjct: 1163 SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS-------HTEMPGTLQAADAAIKKLE 1215

Query: 2474 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK-QMLTEIDSKWQELNQLTIDRQQ 2532
             F + +  N  ++  L +   +L+ E     +  R K   +     K Q+  Q  + R +
Sbjct: 1216 DFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLR 1275

Query: 2533 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATR 2592
               E  + L        +LK W+ EK  M++       +   L+T+ Q+ Q  + E A  
Sbjct: 1276 DNREQQHFLQDCH----ELKLWIDEK--MLTAQDVSYDEARNLHTKWQKHQAFMAELAAN 1329

Query: 2593 KPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKS 2652
            K   +++   G+ +     E P L+ +V E+L  + ++WD L        +   QA  +S
Sbjct: 1330 KDWLDKVDKEGRELTL---EKPELKALVSEKLRDLHRRWDEL--------ETTTQAKARS 1378

Query: 2653 TQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD-------AMNQQLETAQKMKQEIQQEKK 2705
                +     +     L++ L  SL    H D       ++N  L+  Q ++ E+   +K
Sbjct: 1379 LFDANRAELFAQSCCALESWL-ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREK 1437

Query: 2706 QIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQF 2765
            +++  QA      AL +E+    E+ R    + + F+ + Q      + LQ A    HQF
Sbjct: 1438 EVEAIQA---QAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ-ASREQHQF 1493

Query: 2766 QQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGE 2825
             +   D   W+ T++     S      L  ++ L+K ++   K +  Q H  E  IA+  
Sbjct: 1494 HRDVEDEILWV-TERLPMASSMEHGKDLPSVQLLMKKNQTLQKEI--QGH--EPRIAD-- 1546

Query: 2826 NLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWI 2885
             L  + +    AA   +L  ++  W     +++ R  +L+++L     Y++  E    W+
Sbjct: 1547 -LRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEA-EAWM 1604

Query: 2886 DKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV 2945
             + + ++           G+       S Q E+ +H  + + L + A ++  +    +++
Sbjct: 1605 GEQELHM----------MGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDM 1654

Query: 2946 VTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSL 3005
            +  E+    +   +   Q    K     + +   E +E  +E  R  Q  +E  D+   +
Sbjct: 1655 IDHEHP---ESTRISIRQAQVDKL-YAGLKELAGERRERLQEHLRLCQLRRELDDLEQWI 1710

Query: 3006 GSQ---------AYSNKYLTMLQTQQKSLQ-----ALKHQVDLAKRLAQDLVVEASDSKG 3051
              +             +++TML+ + +          + +VD A  LA  L+     ++ 
Sbjct: 1711 QEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARA 1770

Query: 3052 TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSM 3111
            T  V    +++ +  + L + +D +   L    + +  F +  R+  ++      +L   
Sbjct: 1771 T--VAEWKDSLNEAWADLLELLDTRGQVLAAAYE-LQRFLHGARQALARVQHKQQQLPD- 1826

Query: 3112 APVGRD---AETLQKQ----KETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVG 3164
               GRD   AE LQ++    +  I+A   +++ +        K      A E        
Sbjct: 1827 -GTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEE-------- 1877

Query: 3165 IKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE---EHEESQ 3221
            I R ++A+++   +L   + AR + +  T  +   F+  ++E  + + +     + +E  
Sbjct: 1878 IGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKF-RFFKAVRELMLWMDEVNLQMDAQERP 1936

Query: 3222 GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD 3281
              V      I  Q  +     K EIE    +      +G+ L+  A    + + +   L 
Sbjct: 1937 RDVSSADLVIKNQQGI-----KAEIEARADRFSSCIDMGKELL--ARSHYAAEEISEKLS 1989

Query: 3282 DVNARWKTLNKKVAQRAAQLQEAL--LHCGRFQDALESLLSWMVDTEELV 3329
             + AR +   +K  ++   LQ  L  L  GR     E   +W+   E LV
Sbjct: 1990 QLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAE---AWLCSQEPLV 2036



 Score =  106 bits (264), Expect = 7e-22
 Identities = 329/1810 (18%), Positives = 700/1810 (38%), Gaps = 208/1810 (11%)

Query: 2843 LNTIKTNWDTFNKQVKERENKLK------ESLEK-ALKYKEQVETLWPWIDKCQNNLEEI 2895
            ++ I   W+   K   ERE  L+      E LE+ A ++  +      W+ + Q  + + 
Sbjct: 392  ISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQD 451

Query: 2896 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2955
             F L+ A  E ++ K ++++ ++  + G V+ ++  A  L +    D + +     ++ +
Sbjct: 452  NFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVAR 511

Query: 2956 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3015
              D + + + +++  L    +  K FQ                    D L    +  +  
Sbjct: 512  LWDFLRQMVAARRERLLLNLELQKVFQ--------------------DLLYLMDWMEEMK 551

Query: 3016 TMLQTQQ--KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ- 3072
              LQ+Q   + L  ++  + L + +  D+ V+A   +  S   L+     +E+     Q 
Sbjct: 552  GRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQL 611

Query: 3073 VDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3132
            V E+ + LE   + +       R    +               R       +    +A++
Sbjct: 612  VSERVAKLEQSYEALCELAAARRARLEE--------------SRRLWRFLWEVGEAEAWV 657

Query: 3133 KKLEALMASNDNANK-TCKMMLATEETS--PDLVGIKRDLEALSKQCNKLL-------DR 3182
            ++ + L+AS D     T  + L  + T+   ++ G    L+   +Q  +L+        +
Sbjct: 658  REQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQ 717

Query: 3183 AQAREEQVEGTIKRLE----EFYSKLKEFSILLQKAEEHEESQG-----------PVGME 3227
            A AR  +++   +RLE    E   +L + + L Q   +  + +            P    
Sbjct: 718  ASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGH 777

Query: 3228 TETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3287
             E   Q L       +EEI   +     +      L  + +++   QG    L+     +
Sbjct: 778  DEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLE---RHY 834

Query: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLS-------WMVDTEELVANQKPPSA--E 3338
            + L  +  +RA  L+ AL        AL ++LS       W+ + E+ +     P    +
Sbjct: 835  EELQARAGERARALEAAL--------ALYTMLSEAGACGLWVEEKEQWLNGLALPERLED 886

Query: 3339 FKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEA 3398
             +VV+   Q  + L+  ++   + +  +    E++   A P  K +I+     L+ RW+ 
Sbjct: 887  LEVVQ---QRFETLEPEMNTLAAQITAVNDIAEQLLK-ANPPGKDRIVNTQEQLNHRWQQ 942

Query: 3399 LLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQH 3458
                A+ +   L   ++  Q +H        W+    K + + + +G   + +     + 
Sbjct: 943  FRRLADGKKAALTS-ALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKL 1001

Query: 3459 KALEDDI------INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKS 3512
               E D+      +        A++ G   + ++       + ++L   Q  + +++   
Sbjct: 1002 AGTERDLEAIAARVGELTREANALAAGHPAQAVA-------INARLREVQTGWEDLRATM 1054

Query: 3513 HSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST----EGLWKQQSELR 3568
              R E L +A    + F     +   WL      ++  S +  +T    E L  Q + LR
Sbjct: 1055 RRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTAVA--SEEGPATLPEAEALLAQHAALR 1111

Query: 3569 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3628
                ++   +    +    G E+ +     + L ++ +LEA+   ++++ ++       L
Sbjct: 1112 ---GEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168

Query: 3629 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3688
             QA      L    +            +LS +  VL   E            K+ ++  +
Sbjct: 1169 AQAHGFQGFLRDARQA---------EGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMS 1219

Query: 3689 LLDSLNEVSSALLELVPWRAREGLEKMVAEDN---ERYRLVSDTITQKVEEIDAAILR-- 3743
             +D+  E    LLE           ++V+E N   ++ R  +D+I ++ ++   A  +  
Sbjct: 1220 TMDANGERIHGLLEAG--------RQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFL 1271

Query: 3744 --------SQQFDQAADAELSWITETEKKLMSLGDIRLEQDQT-SAQLQVQKTFTMEILR 3794
                     Q F Q       WI E   K+++  D+  ++ +    + Q  + F  E+  
Sbjct: 1272 GRLRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAA 1328

Query: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYD---TICQINSERYLQLERAQS 3851
            +KD +D + K G ++ T    E K  + +KL  + + +D   T  Q  +       RA+ 
Sbjct: 1329 NKDWLDKVDKEGREL-TLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAEL 1387

Query: 3852 LVNQFWETYEELWPWLTETQSIISQLPAP--ALEYETLRQQQEEHRQLRELIAEHKPHID 3909
                F ++   L  WL   +S+ +QL +     +  ++    ++ + L   +A  +  ++
Sbjct: 1388 ----FAQSCCALESWL---ESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVE 1440

Query: 3910 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFH-DKI 3968
             +      L +   G G  ++    A +  +  + + +++R   L +A  +  QFH D  
Sbjct: 1441 AIQAQAKALAQEDQGAG-EVERTSRAVEEKFRALCQPMRERCRRL-QASREQHQFHRDVE 1498

Query: 3969 DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIA 4028
            D+IL   ER+      P + S E  K      +  +V + M+K Q L + + Q  E  IA
Sbjct: 1499 DEILWVTERL------PMASSMEHGK------DLPSVQLLMKKNQTLQKEI-QGHEPRIA 1545

Query: 4029 RSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTI 4088
                  + + A A   +L ++  +W+ +   +E R  +L D +  A++F+ D       +
Sbjct: 1546 DLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALR-AQQFYRDAAEAEAWM 1604

Query: 4089 KDTQDFIRDLEDPGIDPSV---VKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGE 4145
             + +  +   E    + S    VK+ Q   + + +    + +     +   S+ +     
Sbjct: 1605 GEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQ-----LAASSQDMIDHEH 1659

Query: 4146 PDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLA 4205
            P+   +     +++  +  L +   +R ++L+E ++   Q +  L  +  W+      +A
Sbjct: 1660 PESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLC-QLRRELDDLEQWIQ-EREVVA 1717

Query: 4206 SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTE-ESDKHTVQDP 4264
            +   +G D E V    ++ ++F  +     I  ER++    L    +    + + TV + 
Sbjct: 1718 ASHELGQDYEHVTMLRDKFREFSRDT--STIGQERVDSANALANGLIAGGHAARATVAEW 1775

Query: 4265 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 4324
               L   W  L E +  R   L  A   L +F H   + LA + H +  L +    G D 
Sbjct: 1776 KDSLNEAWADLLELLDTRGQVLAAAY-ELQRFLHGARQALARVQHKQQQLPDG--TGRDL 1832

Query: 4325 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4384
             A E    +H   ++D+ A    V+ V   G+ L ++ AG++A  +   ++ + + W  +
Sbjct: 1833 NAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892

Query: 4385 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLAS---KPLGGLPETAKEQLN 4441
               +  R+Q L     + + F   + +L  W+ +    + A    + +       K Q  
Sbjct: 1893 QGSSAARRQLLLDTTDKFRFFKA-VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951

Query: 4442 VHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK 4501
            +  E+    EA+ + + S +  G+++LAR   +AE  I + ++ L+ + +    K  E+ 
Sbjct: 1952 IKAEI----EARADRFSSCIDMGKELLARSHYAAE-EISEKLSQLQARRQETAEKWQEKM 2006

Query: 4502 TKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4561
              L+  L + + F         WL   E  +  A      +D V   I  H+ F     +
Sbjct: 2007 DWLQLVLEV-LVFGRDAGMAEAWLCSQEPLVRSAEL-GCTVDEVESLIKRHEAFQKSAVA 2064

Query: 4562 HREQIIELDK 4571
              E+   L+K
Sbjct: 2065 WEERFCALEK 2074



 Score = 68.9 bits (167), Expect = 1e-10
 Identities = 63/282 (22%), Positives = 116/282 (41%), Gaps = 16/282 (5%)

Query: 606 KFVQDLL---NWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 662
           K  QDLL   +W++EM+ +L   + G  L  VE  L+ H+ V   I      ++    S 
Sbjct: 535 KVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASA 594

Query: 663 IQMTAPLK-------LTYAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNEL 712
           ++   P K          +E++ +LE  Y  L   +  +   L+    L  F+       
Sbjct: 595 LRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAE 654

Query: 713 IWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPA 772
            W+ E++    + D     T   R  + H  L  E+  +   +K   E  +QL+ E HP 
Sbjct: 655 AWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPG 714

Query: 773 RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKY 832
                A  A +Q QW  +  L +   Q + +  + ++F  DA +   +   L DA++   
Sbjct: 715 ASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDMEAW---LVDALRLVS 771

Query: 833 SCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTI 874
           S +        + L ++    +EE+  ++ T+  L  +A  +
Sbjct: 772 SPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAAL 813



 Score = 51.2 bits (121), Expect = 3e-05
 Identities = 48/266 (18%), Positives = 109/266 (40%), Gaps = 24/266 (9%)

Query: 614  WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA---PLK 670
            W+ E ++ +   E   D  S ++ ++ H+ + +A+ ++  ++ +   S   M     P  
Sbjct: 1603 WMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPES 1662

Query: 671  LTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELI----WLNEKEEEEVAYD 726
               + +  +++  YA L   +  +   L   H  + +   EL     W+ E+E    +++
Sbjct: 1663 TRISIRQAQVDKLYAGLKELAGERRERLQE-HLRLCQLRRELDDLEQWIQEREVVAASHE 1721

Query: 727  WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 785
              +   ++   +D   E  R+     +E + S   +A  L+   H AR T+  ++ ++  
Sbjct: 1722 LGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNE 1781

Query: 786  QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLR--------------NLKDAIQRK 831
             W+ +L+L     Q +        F + A++A   ++              N  +A+QR+
Sbjct: 1782 AWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRR 1841

Query: 832  YSCDRSSSIHKLEDLVQESMEEKEEL 857
            + C     I  L   VQ+  ++   L
Sbjct: 1842 H-CAYEHDIQALSPQVQQVQDDGHRL 1866



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 52/280 (18%), Positives = 110/280 (39%), Gaps = 28/280 (10%)

Query: 593 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 649
           +LD  +  E +  K+     +LL W+++  V L+  +  + L  V++ L++  N +R +E
Sbjct: 296 VLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSF-NSYRTVE 354

Query: 650 EFESSLKEAKISEIQMTAPLKL------TYA--------------EKLHRLESQYAKLLN 689
           +     ++  +  +  T   KL       Y               E+L + E +    L 
Sbjct: 355 KPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALR 414

Query: 690 TSRNQERHLDTLH-NFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMREL 748
           T   ++  L+ L   F  +A     WL+E +      ++      +      H  +  ++
Sbjct: 415 TELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDI 474

Query: 749 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 808
                 +++V  +A +L  E +     I A +  +   W ++ Q+     + +  N    
Sbjct: 475 VAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQ 534

Query: 809 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQ 848
           + F D     D++  +K  +Q   S D    +  +EDL+Q
Sbjct: 535 KVFQDLLYLMDWMEEMKGRLQ---SQDLGRHLAGVEDLLQ 571



 Score = 45.8 bits (107), Expect = 0.001
 Identities = 205/1138 (18%), Positives = 417/1138 (36%), Gaps = 193/1138 (16%)

Query: 1113 KKELERLKDDLGTITNKCEEFFSQAAASSSVPTLR-SELNVVLQNMNQVYSMSSTYIDKL 1171
            +++LE +   +G +T +     +   A +     R  E+    +++          + + 
Sbjct: 1005 ERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEA 1064

Query: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVF-- 1229
            + +   L++    +A +   +T +  EE   A     E L++     R EV+  +  +  
Sbjct: 1065 RRLQDFLRSLDDFQAWLGRTQTAVASEEGP-ATLPEAEALLAQHAALRGEVERAQSEYSR 1123

Query: 1230 -HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR------- 1281
              AL +E+ + +A    +F   +   L   W     ++L   W++   ++          
Sbjct: 1124 LRALGEEVTRDQADPQCLFLRQRLEALGTGW-----EELGRMWESRQGRLAQAHGFQGFL 1178

Query: 1282 --LRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQE---NQPENSKTLATQLNQQKM 1336
               R  EG+  S +Y   ++  +   +Q  +   +K+++       N + +   L   + 
Sbjct: 1179 RDARQAEGVLSSQEYVL-SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQ 1237

Query: 1337 LVSEIEMKQSKMDEC-----------QKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVK 1385
            LVSE  +   K+ E            Q  A+Q+   ++D   Q      + D  +     
Sbjct: 1238 LVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQ---HFLQDCHELKLWI 1294

Query: 1386 RRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHV-- 1443
              +M ++ D+   E  +L T++      M + +    D L ++++E + L  EK E    
Sbjct: 1295 DEKMLTAQDVSYDEARNLHTKWQKHQAFMAE-LAANKDWLDKVDKEGRELTLEKPELKAL 1353

Query: 1444 --EKAKELQKWVSNISKT-------LKDAEKAGKPPFS----KQKISSEEISTKKEQLSE 1490
              EK ++L +    +  T       L DA +A     S    +  + S +     +   +
Sbjct: 1354 VSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGK 1413

Query: 1491 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK 1550
             L ++ + L K   +M + E    EK+V+ +Q     L        QE Q +G+V+   +
Sbjct: 1414 DLTSVNILLKKQ--QMLEWEMAVREKEVEAIQAQAKAL-------AQEDQGAGEVERTSR 1464

Query: 1551 IVAERQQEYKEKLQGICDLLTQTENRLIGHQE----------------AFMIGDGTVELK 1594
             V E+ +   + ++  C  L  +  +   H++                +   G     ++
Sbjct: 1465 AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQ 1524

Query: 1595 KYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1654
                K + LQK++QG    +A+        L+E    L     A    +L E +   ++L
Sbjct: 1525 LLMKKNQTLQKEIQGHEPRIAD--------LRERQRALG---AAAAGPELAELQEMWKRL 1573

Query: 1655 NLKAEQSKKELDKVVTTA--IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGT 1712
              + E   K L+  +      ++  E  A + + E      E   D L      S +A  
Sbjct: 1574 GHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDEL------SAQAEV 1627

Query: 1713 KHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHE 1772
            K  QV+EQ    + +   + A   +D ++    E+    ++   Q  +++ Y  +K    
Sbjct: 1628 KKHQVLEQALADYAQTIHQLAASSQDMIDHEHPEST---RISIRQAQVDKLYAGLKE--- 1681

Query: 1773 KIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLT 1832
                                      L+ E +E+LQ++++  +                 
Sbjct: 1682 --------------------------LAGERRERLQEHLRLCQ----------------- 1698

Query: 1833 HSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKG 1892
              L+ EL+       + E W+Q+ E    + E G D  +  M +  + + FS D      
Sbjct: 1699 --LRRELD-------DLEQWIQEREVVAASHELGQDYEHVTMLR-DKFREFSRDT----- 1743

Query: 1893 DLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHA-TDRFRSLYSKCNVLGN 1951
                 TI   RV  A    +    G     AT  E +  L+ A  D    L ++  VL  
Sbjct: 1744 ----STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLA- 1798

Query: 1952 NLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQIS 2011
                   + Q +   +   LA +Q        H  + +   P    R L   +ALQ +  
Sbjct: 1799 ----AAYELQRFLHGARQALARVQ--------HKQQQL---PDGTGRDLNAAEALQRRHC 1843

Query: 2012 SQQVAVEKLKKTAEVLLDARGSLLPA-----KNDIQKTLDDIVGRYEDLSKSVNERNEKL 2066
            + +  ++ L    + + D    L  A       +I + +  +   +  L  S   R + L
Sbjct: 1844 AYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQ-L 1902

Query: 2067 QITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQS 2126
             +  T        + E++ WM  V   +  Q + P + ++   +I     ++ +I  R  
Sbjct: 1903 LLDTTDKFRFFKAVRELMLWMDEVNLQMDAQ-ERPRDVSSADLVIKNQQGIKAEIEARAD 1961

Query: 2127 SINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVEL 2184
              ++  +  K+ +  +    A  +  K+  L AR  E + K +E   KM+ L+  +E+
Sbjct: 1962 RFSSCIDMGKELLARSH-YAAEEISEKLSQLQARRQETAEKWQE---KMDWLQLVLEV 2015



 Score = 43.1 bits (100), Expect = 0.008
 Identities = 62/299 (20%), Positives = 118/299 (39%), Gaps = 36/299 (12%)

Query: 592  SLLDQNLTEEEINMKFVQD---LLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAI 648
            SL D N  E      F Q    L +W++ +Q QL   ++G DL SV   L+  + +    
Sbjct: 1378 SLFDANRAE-----LFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQML---- 1428

Query: 649  EEFESSLKEAKISEIQMTAPLKLT------YAEKLHR-LESQYAKLLNTSRNQERHLDT- 700
             E+E +++E ++  IQ  A             E+  R +E ++  L    R + R L   
Sbjct: 1429 -EWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQAS 1487

Query: 701  --LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSV 758
               H F     +E++W+ E+     + +  +   ++      +  L +E+   E  I  +
Sbjct: 1488 REQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADL 1547

Query: 759  QEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 818
            +E    L        L      A +Q  W  +    +   + +++     +F+ DA EA 
Sbjct: 1548 RERQRALGAAAAGPEL------AELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAE 1601

Query: 819  DYL--RNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTII 875
             ++  + L    Q K   + S+        V++    ++ L  Y  TI  L   ++ +I
Sbjct: 1602 AWMGEQELHMMGQEKAKDELSAQAE-----VKKHQVLEQALADYAQTIHQLAASSQDMI 1655



 Score = 40.8 bits (94), Expect = 0.037
 Identities = 37/205 (18%), Positives = 84/205 (40%), Gaps = 16/205 (7%)

Query: 608  VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQM-- 665
            V+D + WV E        E G DLPSV+  ++ ++ + + I+  E  + + +  +  +  
Sbjct: 1497 VEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGA 1556

Query: 666  ------TAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKE 719
                   A L+  +    H LE +  +L +  R Q+ + D        A     W+ E+E
Sbjct: 1557 AAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRD--------AAEAEAWMGEQE 1608

Query: 720  EEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAY 779
               +  + ++   +   +   H  L + L    + I  +   ++ ++   HP    I   
Sbjct: 1609 LHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIR 1668

Query: 780  RAAMQTQWSWILQLCQCVEQHIKEN 804
            +A +   ++ + +L     + ++E+
Sbjct: 1669 QAQVDKLYAGLKELAGERRERLQEH 1693



 Score = 40.4 bits (93), Expect = 0.049
 Identities = 44/225 (19%), Positives = 86/225 (38%), Gaps = 5/225 (2%)

Query: 610 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPL 669
           D+  W+ +    +   E G D  S ++    H+ +   I     +L   +     +   L
Sbjct: 758 DMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTL 817

Query: 670 KLT--YAEKLHRLESQYAKLLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVA 724
             T     ++  LE  Y +L   +  + R L+    L+  +S A    +W+ EKE+    
Sbjct: 818 SRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNG 877

Query: 725 YDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQ 784
               ER  ++   +     L  E++     I +V +IAEQLL  N P +  I   +  + 
Sbjct: 878 LALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLN 937

Query: 785 TQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQ 829
            +W    +L    +  +    +   +  +  E   ++R     I+
Sbjct: 938 HRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIE 982



 Score = 38.5 bits (88), Expect = 0.19
 Identities = 59/307 (19%), Positives = 124/307 (40%), Gaps = 44/307 (14%)

Query: 1264 ADQLVERWQNVHVQI-DNRLRDL---EGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 1319
            A Q + R Q+   Q+ D   RDL   E + +    Y      L   +QQV+    ++Q+ 
Sbjct: 1810 ARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKA 1869

Query: 1320 QPENSKTLATQLNQQKMLVSEI---------EMKQSKMDECQKYAEQYSATVKDYELQTM 1370
               +    A ++ +    V+E            +Q  +D   K+  ++   V++  L   
Sbjct: 1870 YAGDK---AEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKF--RFFKAVRELMLWMD 1924

Query: 1371 TYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT-------RYTALVTLMTQYIKFAGD 1423
                 +D+Q+     R R  SSADL+I+    ++        R+++ + +  + +  +  
Sbjct: 1925 EVNLQMDAQE-----RPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHY 1979

Query: 1424 SLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEIST 1483
            + + + E+   L+  ++E  EK +E   W+  + + L     AG    ++  + S+E   
Sbjct: 1980 AAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAG---MAEAWLCSQEPLV 2036

Query: 1484 KKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSG 1543
            +  +L   +  ++  + +H            +K     +E +  L  E L  L+E +   
Sbjct: 2037 RSAELGCTVDEVESLIKRH---------EAFQKSAVAWEERFCAL--EKLTALEEREKER 2085

Query: 1544 DVKVEEK 1550
              K EE+
Sbjct: 2086 KRKREEE 2092



 Score = 33.5 bits (75), Expect = 6.0
 Identities = 24/100 (24%), Positives = 45/100 (45%), Gaps = 8/100 (8%)

Query: 606  KFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE----EFESSLKEAKIS 661
            K V++L+ W+DE+ +Q+D  E   D+ S +  ++N + +   IE     F S +   K  
Sbjct: 1914 KAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGK-- 1971

Query: 662  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL 701
              ++ A       E   +L    A+   T+   +  +D L
Sbjct: 1972 --ELLARSHYAAEEISEKLSQLQARRQETAEKWQEKMDWL 2009


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  311 bits (798), Expect = 9e-84
 Identities = 356/1658 (21%), Positives = 728/1658 (43%), Gaps = 226/1658 (13%)

Query: 605  MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 661
            +K V   +NW   V+E   +L+   +G+DLP V+  +E H   H  ++     L  AK  
Sbjct: 129  VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186

Query: 662  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 721
            + +  + L+           ++Y KLL  S+ +++HL +L +++ R TNEL WL+++ + 
Sbjct: 187  DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235

Query: 722  EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780
             + YDWS+RN +  +R++ Y   + R L+ KEE I  +    +QLL   HP R +IEA+ 
Sbjct: 236  RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295

Query: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840
             A+   W   L L  C E H+K    Y +F  D K+A + LR +   + +KY  D     
Sbjct: 296  EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354

Query: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900
            +++E L++E  ++++ L +Y+  +  L  + + ++ LK R  + PLK  IP++A+CD+  
Sbjct: 355  YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412

Query: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960
             +  I +     L  N+  + W+++   GN+ + P+VCF +PP + EA+ LA+ +  QY+
Sbjct: 413  EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471

Query: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020
            +V     +     K  +   Y +             +KT  PG+     S+LQ R     
Sbjct: 472  SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505

Query: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080
                  Q+ +G D                    +++ + QE+++  +             
Sbjct: 506  ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528

Query: 1081 NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 1139
                     +R PLE+   + +S  R  + + +  EL R++ +    T + E F      
Sbjct: 529  ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579

Query: 1140 SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 1199
            S + P LR+ +    +    +  +     +K+   N + K+ Q +  L+  +E  L +++
Sbjct: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639

Query: 1200 AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 1259
             V      +++    L     E+  ++ +   +E  LQ AK  S  +   ++E   D + 
Sbjct: 640  TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699

Query: 1260 HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 1319
             + +  +L +R+ N+  Q++ R + L+    S K   + +H   D + Q   +    +  
Sbjct: 700  QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755

Query: 1320 QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1377
            + ++   + T+L  QK L+ EI  ++ ++ +    ++QY   VKDYEL+    R+++D  
Sbjct: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815

Query: 1378 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEK 1433
              +     KR R+QS A  + +E   L  ++T +  +     Q ++FA + L++  E E 
Sbjct: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875

Query: 1434 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQ------ 1487
            + E  ++   +   E + W   I K L +  +  +   ++ K + EEI T + Q      
Sbjct: 876  THETLQRNRPDSGVE-EAW--KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESV 932

Query: 1488 -------------LSEALQTIQLFLA--KHGDKMTDEERNELEKQVKTLQE-----SYNL 1527
                         L E+ Q +Q  LA  +H +++  EE   L+ Q++ L++         
Sbjct: 933  VRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEY 992

Query: 1528 LFSESLK-QLQESQTSGDVKVEEKIVAERQQE---------YKEKLQGICDLLTQTENRL 1577
            +  E L+ +   +Q    +++ E++ A R+Q+          ++++  + +  ++ + ++
Sbjct: 993  VVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKV 1052

Query: 1578 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1637
               +   +  D  +E  +YQ  QE+ Q+  Q     L E  +   +FL++  ++L +E +
Sbjct: 1053 TEKEVVKLQNDPQLE-AEYQQLQEDHQRQDQ-----LREKQEEELSFLQDKLKRLEKE-R 1105

Query: 1638 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1697
            A+ E K+   ++      LK E+     ++ V+   ++  ++ A  +  +  KT++   +
Sbjct: 1106 AMAEGKITVKEV------LKVEKD-AATEREVSDLTRQYEDEAAKARASQREKTELLRKI 1158

Query: 1698 DWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ 1757
             W      + E A    K V+++        D K+   E +  N  L   + + +    +
Sbjct: 1159 -WA----LEEENA----KVVVQEKVREIVRPDPKA---ESEVANLRLELVEQERKYRGAE 1206

Query: 1758 ENLNQQYQKVKAQHEK---IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----N 1810
            E L     +++A   +   +  +     +        +EK+ Q L  E  +K +     +
Sbjct: 1207 EQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCD 1266

Query: 1811 MKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDI 1870
            ++  ++  E    +  K    T  + +E+ +F  D         Q+++E+ +L A   + 
Sbjct: 1267 LEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQED--------PQTKEEVASLRAKLSEE 1318

Query: 1871 NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQ- 1929
                  L+R+++  E+ I+ K +     +    V +      +  G + + SA    +  
Sbjct: 1319 QKKQVDLERERASQEEQIARKEE-ELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDV 1377

Query: 1930 --RKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL------LAGLQACEATA 1981
              R++D      R L  +   L   L++L  + Q   +A   +      LA L+  EA A
Sbjct: 1378 ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEA 1437

Query: 1982 SKHLSEPIAV----DPKN------LQRQLEE----TKALQGQISS---QQVAVEKLKKTA 2024
             + ++    V    DP+       L+ QLEE     + L+G++ +   +  A+EK +   
Sbjct: 1438 REKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKE 1497

Query: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084
            +V+L    S+   K D ++ +  +    E+ S+S  E    L + ++R   ++  L E+ 
Sbjct: 1498 KVVLSE--SVQVEKGDTEQEIQRLKSSLEEESRSKRE----LDVEVSR---LEARLSEL- 1547

Query: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144
                N +SS KE   +   +  LQ +  +N+ LE      QS IN    + +     T  
Sbjct: 1548 -EFHNSKSS-KELDFLREENHKLQ-LERQNLQLE--TRRLQSEINMAATETRDLRNMTVA 1602

Query: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2182
             + ++  +++  L     +     K+   +++EL+ ++
Sbjct: 1603 DSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRL 1640



 Score = 84.0 bits (206), Expect = 4e-15
 Identities = 326/1767 (18%), Positives = 699/1767 (39%), Gaps = 272/1767 (15%)

Query: 1590 TVELKKYQSKQ-EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQ----EDKALIEQKL 1644
            TV+ +   +K+  EL + +Q +A  + + + +TE  ++ +  +L +    E + +  QK+
Sbjct: 16   TVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKV 75

Query: 1645 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA--VKQLEESKTKIENLLDWLSN 1702
             +++     L         E D  +   +K     + A  ++QL+E  T +         
Sbjct: 76   LDSEKLLYVL---------EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRG------- 119

Query: 1703 VDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE--DEVNGNLLETD---VDGQVGTTQ 1757
                      KHKQ+              +A+ EE  D++N     TD   VD QV    
Sbjct: 120  ----------KHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV---- 165

Query: 1758 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVH 1817
            E  N  + +VKA     I  H A                       K+  ++   EL+  
Sbjct: 166  EEHNIFHNEVKA-----IGPHLA-----------------------KDGDKEQNSELRAK 197

Query: 1818 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1877
            Y+  LA S+ + +   SLQ+ +++     T   +WL Q  +     +    +++    + 
Sbjct: 198  YQKLLAASQARQQHLSSLQDYMQRC----TNELYWLDQQAKGRMQYDWSDRNLDYPSRRR 253

Query: 1878 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1937
            + +   + ++ + +  +  +   G+++L A      R+  +    A H + +  L+    
Sbjct: 254  QYENFINRNLEAKEERINKLHSEGDQLLAAEHP--GRNSIEAHMEAVHADWKEYLNLLI- 310

Query: 1938 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 1997
                    C    ++LK + D +Q +ED         Q         L++    D K+ +
Sbjct: 311  --------CEE--SHLKYMEDYHQFHEDVK-----DAQELLRKVDSDLNQKYGPDFKD-R 354

Query: 1998 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2057
             Q+E    L  ++  Q+  ++K +   + L      ++P K   +  L  I      +  
Sbjct: 355  YQIE---LLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPI-----PVEA 406

Query: 2058 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV----PLNSTAL---QDI 2110
              +   E+  I+   S ++Q    E  + M +  + L          P +  AL     +
Sbjct: 407  LCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSL 466

Query: 2111 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK--MKDLSARFSEASHKH 2168
             S+   + Q  AG + ++    E +K    T +P  AS LQ +  +  L    S+   + 
Sbjct: 467  GSQYRSVRQKAAGSKRTLQQRYEVLK----TENPGDASDLQGRQLLAGLDKVASDLDRQE 522

Query: 2169 K----------ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD-----VPGKDV 2213
            K          E    +++   + +  +N++ +L      KT++  E +     +PG   
Sbjct: 523  KAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGT 582

Query: 2214 TELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH---GLPSDKALVLEKTNNLSKKFKEM 2270
            T L +   E T+   EH   L  L     ++++     L     L+    N+L++     
Sbjct: 583  TPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQ----- 637

Query: 2271 EDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2330
            +DT+ E    + S  ++L A    +++ KS + E              ++L  + + +  
Sbjct: 638  DDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVE------------QNLQAAKQCSST 685

Query: 2331 LQEKWSLKTPEIQK----VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2386
            L  ++    P++++    V+  G    NL   V   A+++ + K+              E
Sbjct: 686  LASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAA------------YE 733

Query: 2387 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKM 2446
             F  ++G   + + +  I   YE       D ++++ TKL   +   +E ++  Q +QK+
Sbjct: 734  HF--HRGHDHVLQFLVSIP-SYEPQET---DSLSQMETKLKNQKNLLDEIASREQEVQKI 787

Query: 2447 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2506
               + ++QQ     + EA K  +      E     +V+K   L+   T++ EE  +   A
Sbjct: 788  CANSQQYQQAVKDYELEAEK--LRSLLDLENGRSSHVSKRARLQSPATKVKEE--EAALA 843

Query: 2507 PRWKQMLTEIDSKWQELN-QLTIDRQQKLEESSNNLTQFQTVEAQLKQ-WLVEKELMVSV 2564
             ++ ++      + Q L   L + RQQ   E ++   Q    ++ +++ W + KEL    
Sbjct: 844  AKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEET 903

Query: 2565 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2624
                 ++  + +TQ        +E  T + Q  Q +   + +L +   DP L    ++  
Sbjct: 904  ERRRQLENEVKSTQ--------EEIWTLRNQGPQESVVRKEVLKKV-PDPVLEESFQQLQ 954

Query: 2625 AAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2684
              + ++            + + Q  +++ Q Q  LR+L  +  D   +      +   PD
Sbjct: 955  RTLAEE---------QHKNQLLQEELEALQLQ--LRALEQETRDGGQEYVVKEVLRIEPD 1003

Query: 2685 AMNQQLETAQKMKQEIQQEKKQIKVAQA---LCEDLSALVKEEYLKAELSRQLEGILKSF 2741
                Q +   ++++E++  ++Q    +A   L +   A + EE  +A+     + ++K  
Sbjct: 1004 --RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQ 1061

Query: 2742 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2801
             D + +AE   Q LQ       Q ++   +  ++L  K +   K   ++     ++ ++K
Sbjct: 1062 NDPQLEAE--YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLK 1119

Query: 2802 DHKDFS--KTLTAQSHMYEKTIA-------EGENLLLKTQGSE----KAALQLQLNTI-- 2846
              KD +  + ++  +  YE   A       E   LL K    E    K  +Q ++  I  
Sbjct: 1120 VEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVR 1179

Query: 2847 ---KTNWDTFNKQVK--ERENKLKESLEKALKYKEQVETL---WPWIDKCQNNLEEIKFC 2898
               K   +  N +++  E+E K + + E+   Y+ ++E L    P ++  +   E IK+ 
Sbjct: 1180 PDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYK 1239

Query: 2899 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV-VTDENKSLIQKV 2957
             DP   +    +L+ L++E+     ++E  +      L + ++ KE+    + K  +Q  
Sbjct: 1240 TDPEMEK----ELQRLREEIVDKTRLIERCD------LEIYQLKKEIQALKDTKPQVQTK 1289

Query: 2958 DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTM 3017
            ++V E L  ++   +   +      ++S+E K+Q+   +E+    + +   A   + L+ 
Sbjct: 1290 EVVQEILQFQE-DPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQI---ARKEEELSR 1345

Query: 3018 LQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3077
            ++ +    + ++++ +   R       E+ D +     L Q++ +  E   L ++  E  
Sbjct: 1346 VKERVVQQEVVRYEEEPGLRAEASAFAESIDVE-----LRQIDKLRAELRRLQRRRTE-- 1398

Query: 3078 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3137
              LE +L+ +   +   RE   +       L ++     +AE  +K   T K  L++   
Sbjct: 1399 --LERQLEELERERQARREAEREVQRLQQRLAALEQ--EEAEAREKVTHTQKVVLQQ--- 1451

Query: 3138 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3197
                   A +   + L  EE       ++ +LE L ++    L++A+ +E+ V     ++
Sbjct: 1452 ---DPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKL-AALEKAEVKEKVVLSESVQV 1507

Query: 3198 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV----------FQKEEIE 3247
            E+  ++ +E   L    EE   S+  + +E   +  +L+  +           F +EE  
Sbjct: 1508 EKGDTE-QEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566

Query: 3248 PLQGKQQDVNWLGQGLIQSAAKSTSTQ 3274
             LQ ++Q++  L    +QS     +T+
Sbjct: 1567 KLQLERQNLQ-LETRRLQSEINMAATE 1592



 Score = 80.5 bits (197), Expect = 4e-14
 Identities = 170/848 (20%), Positives = 339/848 (39%), Gaps = 150/848 (17%)

Query: 3260 GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLL 3319
            G+  IQ+   S +T  L   ++D N +++ L     Q     QE +    R + +L+   
Sbjct: 570  GEAFIQALPGSGTTPLLRTRVEDTNRKYEHL----LQLLDLAQEKVDVANRLEKSLQQ-- 623

Query: 3320 SW-MVDTEELVANQK---PPSA--------EFKVVKAQIQEQKLLQRLLDDRKSTVEVIK 3367
            SW ++ T E   NQ    P S+        E   +  ++Q QK    LL + +  ++  K
Sbjct: 624  SWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQK---SLLGEVEQNLQAAK 680

Query: 3368 REGEKIATTAEP--ADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3425
            +    +A+  +    D  +   ++  L  R+  L  + E R + L+      + FH   +
Sbjct: 681  QCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD 740

Query: 3426 PLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLK- 3483
             + ++L +I     + EP  T + S++E ++   K L D+I +  + + +  +  Q  + 
Sbjct: 741  HVLQFLVSIP----SYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQ 796

Query: 3484 -VLSSREDKDMVQSKLDFSQVWYIEIQEKSH-SRSELLQQALCNAKIFGEDEVELMNWLN 3541
             V     + + ++S LD      +E    SH S+   LQ      K   E+E  L     
Sbjct: 797  AVKDYELEAEKLRSLLD------LENGRSSHVSKRARLQSPATKVK---EEEAALAAKFT 847

Query: 3542 EVHDKLSKLSVQDYSTE-GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3600
            EV+  +++  +Q+      L +QQ E+ V  E +   + +      +G+E          
Sbjct: 848  EVY-AINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPD------SGVE---------- 890

Query: 3601 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK------VEV 3654
                           +  K+  ++ +  E+  QL   + ST EE+ T  ++      V  
Sbjct: 891  ---------------EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRK 935

Query: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3714
            E+L      +  E   Q Q   + L +E   N+ L + L E     L  +    R+G ++
Sbjct: 936  EVLKKVPDPVLEESFQQLQ---RTLAEEQHKNQLLQEEL-EALQLQLRALEQETRDGGQE 991

Query: 3715 MVAEDNERY---RLVSDTITQKVEEIDAA----------ILRSQQFDQAADAELSWITE- 3760
             V ++  R    R  +D + Q  EE++A           +L  QQ   A   E S   E 
Sbjct: 992  YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEK 1051

Query: 3761 -TEKKLMSL-GDIRLE------------QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806
             TEK+++ L  D +LE            QDQ   + + + +F  + L+  +    + +  
Sbjct: 1052 VTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGK 1111

Query: 3807 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866
              +      E+  + ++++  + + Y+   +    R  Q E+ + L+ + W   EE    
Sbjct: 1112 ITVKEVLKVEKDAATEREVSDLTRQYED--EAAKARASQREKTE-LLRKIWALEEENAKV 1168

Query: 3867 LTETQSIISQLPAPALEYET------LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3920
            + + +      P P  E E       L +Q+ ++R   E +  ++  ++ + + GPQ   
Sbjct: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQ--- 1225

Query: 3921 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 3980
                    ++ K V  + +  +   +++K    L E I   T+  ++ D  +  L++ ++
Sbjct: 1226 --------VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQ 1277

Query: 3981 RLR-------------------QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ 4021
             L+                   + P    EV  ++ ++SE +   VD+E+ +   E    
Sbjct: 1278 ALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIA 1337

Query: 4022 RGEEMIAR 4029
            R EE ++R
Sbjct: 1338 RKEEELSR 1345



 Score = 71.2 bits (173), Expect = 3e-11
 Identities = 264/1303 (20%), Positives = 495/1303 (37%), Gaps = 209/1303 (16%)

Query: 3914 TGPQLLELSPGEGF---SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3970
            T P+ L L+   G    S+++K   +     Q + +V K     D +  Q  Q    +D+
Sbjct: 455  TDPEALALADSLGSQYRSVRQKAAGSKRTLQQ-RYEVLKTENPGDASDLQGRQLLAGLDK 513

Query: 3971 ILESLER----IVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026
            +   L+R    I   LR P      V+   E+  + KN++ ++ +++P        GE  
Sbjct: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573

Query: 4027 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4086
            I    G+    +   ++ +++     +E++  L++  + K +DV    EK       L+ 
Sbjct: 574  IQALPGSG---TTPLLRTRVEDTNRKYEHLLQLLDLAQEK-VDVANRLEKSLQQSWELLA 629

Query: 4087 TIKD-------TQDFIRDLEDPGIDPSVVKQQQEAAETIREEID-GLQEELDIVINLGSE 4138
            T ++         +  R L+  G + + +  + +A +++  E++  LQ        L S 
Sbjct: 630  THENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASR 689

Query: 4139 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG----LQAVF 4194
                C  PD    +  + +L   +++L +  + R   L+ A  A   +  G    LQ + 
Sbjct: 690  FQEHC--PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLV 747

Query: 4195 DWVDIAGGKLASMSPIGTDLETVKQQIEELKQ---------FKSEAYQQ-----QIEMER 4240
                    +  S+S + T L+  K  ++E+             S+ YQQ     ++E E+
Sbjct: 748  SIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEK 807

Query: 4241 LNHQAELLLKKVTEESDKHTVQDPLMELK-----LIWDSLEERIINRQ--HKLEGALLAL 4293
            L    +L   + +  S +  +Q P  ++K     L     E   INRQ    LE AL  L
Sbjct: 808  LRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLL 867

Query: 4294 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI------ELAKHHVLQNDVLAHQST 4347
             Q           +  T   L   +P  G  +A +I      E  +   L+N+V + Q  
Sbjct: 868  RQQPE--------VEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEE 919

Query: 4348 VEAVNKAGNDLIESSAGEEASNL--QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGF 4405
            +  +   G    ES   +E         LE   Q+ Q  L + EQ K QL          
Sbjct: 920  IWTLRNQGPQ--ESVVRKEVLKKVPDPVLEESFQQLQRTLAE-EQHKNQL---------L 967

Query: 4406 HGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA---KEETYKSLMQ 4462
              E+E LQ  L   E+        GG     KE L +  +   A E    +EE      Q
Sbjct: 968  QEELEALQLQLRALEQETRD----GGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQ 1023

Query: 4463 KGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK-TKLEEALNLAMEFHNSLQDF 4521
            KG +      ++    + Q +  L E+    + K+ E++  KL+    L  E+    +D 
Sbjct: 1024 KGAR------EAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDH 1077

Query: 4522 INWLTQAEQTLNVASRPSL-ILDTVLFQID------EHKVFANEV-NSHREQIIELDKTG 4573
                 Q +  L       L  L   L +++      E K+   EV    ++   E + + 
Sbjct: 1078 -----QRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSD 1132

Query: 4574 THLKY--------FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4625
               +Y         SQ++   L++ +    +   + VVQ  V      +  R   K   E
Sbjct: 1133 LTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVR-----EIVRPDPKAESE 1187

Query: 4626 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685
              +  +E +E+  K   +E            QL  ++   ++L  +    +    T   +
Sbjct: 1188 VANLRLELVEQERKYRGAE-----------EQLRSYQSELEALRRRGPQVEVKEVTKEVI 1236

Query: 4686 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4745
            K KT     + +++  L  LR+       + V++   +E   L   Q    +QAL D   
Sbjct: 1237 KYKT-----DPEMEKELQRLRE-------EIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284

Query: 4746 RVEPQLAEDQPVHGDID-LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS 4804
            +V+ +    + +    D      + + +A   E  K+   ++  + S  E I    ++ S
Sbjct: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344

Query: 4805 WVKVQ-MQELSTRWETVCALSISKQT---RLEAALRQAEEFHSVVHALLEWLAEAEQTLR 4860
             VK + +Q+   R+E    L          ++  LRQ ++  + +  L     E E+ L 
Sbjct: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404

Query: 4861 FHGVLPDDEDALRTL---IDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 4917
                L  +  A R     + + ++ +  LE++ AE  +  T   T   +   D     +H
Sbjct: 1405 ---ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVT--HTQKVVLQQDPQQAREH 1459

Query: 4918 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 4977
               ++R + EE     +QH+++L      L  + E L   LA L+ AE     K+K V+ 
Sbjct: 1460 --ALLRLQLEE-----EQHRRQL------LEGELETLRRKLAALEKAEV----KEKVVLS 1502

Query: 4978 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKR 5037
            + ++       E     +E+ R +  +++ +++ +    + S L++ +  L+   +   +
Sbjct: 1503 ESVQ------VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556

Query: 5038 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR---KLNDALDRLEELREF- 5093
                 L     + Q+E +N               L LE RR   ++N A     +LR   
Sbjct: 1557 -ELDFLREENHKLQLERQN---------------LQLETRRLQSEINMAATETRDLRNMT 1600

Query: 5094 -----ANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKI 5131
                  N D  +W             R +D  +R+ KD+D +I
Sbjct: 1601 VADSGTNHDSRLW----------SLERELDDLKRLSKDKDLEI 1633



 Score = 66.6 bits (161), Expect = 6e-10
 Identities = 250/1287 (19%), Positives = 495/1287 (38%), Gaps = 203/1287 (15%)

Query: 2459 PTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDS 2518
            PTD EA+         + +  ++     + L+ +   L  ENP      + +Q+L  +D 
Sbjct: 454  PTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDK 513

Query: 2519 KWQELNQ-----------------LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2561
               +L++                    D  ++ ++  N   +   +E +  +   E E  
Sbjct: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573

Query: 2562 VSVLGPLSIDP----NMLNTQRQQVQIL-LQEFATRK-----------PQYEQLTAAGQG 2605
            +  L      P     + +T R+   +L L + A  K            Q  +L A  + 
Sbjct: 574  IQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHEN 633

Query: 2606 ILSRPGEDPSLRGIVK---EQLAAVT---QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLL 2659
             L++    P    ++    ++LAA+    Q   SL G+       ++Q +  + Q  S L
Sbjct: 634  HLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGE-------VEQNLQAAKQCSSTL 686

Query: 2660 RS-LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI-KVAQALCEDL 2717
             S   +   DL+ + +    +    + + QQ+E   +  Q  +   +   +    + + L
Sbjct: 687  ASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFL 746

Query: 2718 SALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD 2777
             ++   E  + +   Q+E  LK+ K++  +  +  Q +Q  CA+S Q+QQ  +D++  L+
Sbjct: 747  VSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYE--LE 804

Query: 2778 TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKA 2837
             +K               L SL+      S      SH+ ++   +     +K    E+A
Sbjct: 805  AEK---------------LRSLLDLENGRS------SHVSKRARLQSPATKVK---EEEA 840

Query: 2838 ALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF 2897
            AL  +   +       N+Q         ++LE AL    Q           Q  +E    
Sbjct: 841  ALAAKFTEVY----AINRQ-------RLQNLEFALNLLRQ-----------QPEVEVTHE 878

Query: 2898 CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN------- 2950
             L     ++ + +   ++KE+D+       L N   S        +E+ T  N       
Sbjct: 879  TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKS------TQEEIWTLRNQGPQESV 932

Query: 2951 --KSLIQKV-DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3007
              K +++KV D V E+   +   L+    + +   ++ +E    LQ     L+     G 
Sbjct: 933  VRKEVLKKVPDPVLEESFQQ---LQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGG 989

Query: 3008 QAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL-VVEASDSKGTSDVLL---QVETIA 3063
            Q Y  K +  ++         + Q D   +L ++L  +        ++VLL   +V  +A
Sbjct: 990  QEYVVKEVLRIEPD-------RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALA 1042

Query: 3064 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3123
            +E S   ++V EK      KLQ        +   + Q  E     D +          +K
Sbjct: 1043 EEKSRAQEKVTEK---EVVKLQN----DPQLEAEYQQLQEDHQRQDQLR---------EK 1086

Query: 3124 QKETIKAFLKKLEALMASNDNANK--TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD 3181
            Q+E +     KL+ L      A    T K +L  E+ +      +R++  L++Q     +
Sbjct: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA----ATEREVSDLTRQYED--E 1140

Query: 3182 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3241
             A+AR  Q E T + L + ++  +E + ++ + +  E  +     E+E  N +L + +  
Sbjct: 1141 AAKARASQREKT-ELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQE 1199

Query: 3242 QKEE--IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD-DVNARWKTLNKKVAQRA 3298
            +K     E L+  Q ++  L +   Q   K  + + +++  D ++    + L +++  + 
Sbjct: 1200 RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKT 1259

Query: 3299 AQLQEALLHCGRFQDALESLLSW--MVDTEELVAN----QKPPSAEFKVVKAQI---QEQ 3349
              ++   L   + +  +++L      V T+E+V      Q+ P  + +V   +    +EQ
Sbjct: 1260 RLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQ 1319

Query: 3350 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI-----------------------L 3386
            K    L  +R S  E I R+ E+++   E   + ++                       L
Sbjct: 1320 KKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVEL 1379

Query: 3387 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET---LEPLNEWLTTIEKRLVNCEP 3443
            +Q+  L +    L  +     RQLE +    Q   E    ++ L + L  +E+       
Sbjct: 1380 RQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEARE 1439

Query: 3444 IGTQASKL----EEQIAQHKALEDDIINHNKHLHQAVSIG-QSLKVLSSREDKDMVQSKL 3498
              T   K+    + Q A+  AL    +   +H  Q +    ++L+   +  +K  V+ K+
Sbjct: 1440 KVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKV 1499

Query: 3499 DFSQVWYIE----IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ- 3553
              S+   +E     QE    +S L +++    ++  E    L   L+E+    SK S + 
Sbjct: 1500 VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVS-RLEARLSELEFHNSKSSKEL 1558

Query: 3554 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR 3613
            D+  E   K Q E + LQ +    +  ++ A     +L   T  D       +L +++  
Sbjct: 1559 DFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERE 1618

Query: 3614 YKDITKLSTDVAKTLEQALQLARRLHS 3640
              D+ +LS D  K LE   +L +RL S
Sbjct: 1619 LDDLKRLSKD--KDLE-IDELQKRLGS 1642



 Score = 64.3 bits (155), Expect = 3e-09
 Identities = 213/1162 (18%), Positives = 459/1162 (39%), Gaps = 155/1162 (13%)

Query: 3602 IIQDKLEAIKARYK------DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655
            +++ ++E    +Y+      D+ +   DVA  LE++LQ +  L +THE      D V   
Sbjct: 585  LLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPES 644

Query: 3656 LLSYETQVLKGEE----ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG 3711
                ++   KG+E    A + Q +   L +  +N +A     + ++S   E  P   R+ 
Sbjct: 645  SRVLDS---KGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ- 700

Query: 3712 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI 3771
             E  V +  +R+  +   + ++ + + +A    + F +  D  L +       L+S+   
Sbjct: 701  -EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQF-------LVSIPSY 752

Query: 3772 RLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEK-QSMKKKLDKVLK 3830
              ++  + +Q++       ++   K+++D++     ++   C+  ++ Q   K  +   +
Sbjct: 753  EPQETDSLSQMET------KLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAE 806

Query: 3831 NYDTICQINSERYLQLE---RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYE-T 3886
               ++  + + R   +    R QS   +  E    L    TE  +I  Q     LE+   
Sbjct: 807  KLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQ-RLQNLEFALN 865

Query: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946
            L +QQ E     E +  ++P             +    E + I+++         Q++ +
Sbjct: 866  LLRQQPEVEVTHETLQRNRP-------------DSGVEEAWKIRKELDEETERRRQLENE 912

Query: 3947 VKKRAVALDEAISQSTQFHDKIDQILESL-ERIVERLRQPPSISAEVEKIKEQISENKNV 4005
            VK     +    +Q  Q      ++L+ + + ++E   Q    +   E+ K Q+ + +  
Sbjct: 913  VKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELE 972

Query: 4006 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREA 4065
            ++ ++ L+ L +  +  G+E + +     + +  +  + + D+++ + E +  L  ++ A
Sbjct: 973  ALQLQ-LRALEQETRDGGQEYVVK-----EVLRIEPDRAQADEVLQLREELEALRRQKGA 1026

Query: 4066 KLLDVMELAEKF--WCDHMSLIVTIKDTQDFIRDLEDPGIDPSVV------KQQQEAAET 4117
            +  +V+ L ++     +  S        ++ ++   DP ++          ++Q +  E 
Sbjct: 1027 REAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK 1086

Query: 4118 IREEIDGLQEELDIVINLGSELIAACG----------EPDKPIVKKSIDELNSAWDSLNK 4167
              EE+  LQ++L     L  E   A G          E D    ++  D      D   K
Sbjct: 1087 QEEELSFLQDKLK---RLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAK 1143

Query: 4168 AWKDRIDKLE--------EAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQ 4219
            A   + +K E        E   A V  Q+ ++ +      A  ++A++      LE V+Q
Sbjct: 1144 ARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLR-----LELVEQ 1198

Query: 4220 QIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDSLEER 4278
            +  + +  + +    Q E+E L  +  ++ +K+VT+E  K+   DP ME +L    L E 
Sbjct: 1199 E-RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKT-DPEMEKEL--QRLREE 1254

Query: 4279 IINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE--IELAKHHV 4336
            I+++   +E   L + Q +  +             L + KP     + ++  ++  +   
Sbjct: 1255 IVDKTRLIERCDLEIYQLKKEIQ-----------ALKDTKPQVQTKEVVQEILQFQEDPQ 1303

Query: 4337 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQ-- 4394
             + +V + ++ +    K   DL    A +E   +  K E L++  + V+++   R ++  
Sbjct: 1304 TKEEVASLRAKLSEEQKKQVDLERERASQE-EQIARKEEELSRVKERVVQQEVVRYEEEP 1362

Query: 4395 ------------LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV 4442
                        +D  LRQ      E+  LQ+  T+ ER L   +        A+ ++  
Sbjct: 1363 GLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQR 1422

Query: 4443 HMEVCAAFEAKE--------ETYKSLMQKGQQM-----LARCPKSAETN----IDQDINN 4485
              +  AA E +E         T K ++Q+  Q      L R     E +    ++ ++  
Sbjct: 1423 LQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELET 1482

Query: 4486 LKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTV 4545
            L+ K  ++E      K +++E + L+        D    + + + +L   SR    LD  
Sbjct: 1483 LRRKLAALE------KAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVE 1536

Query: 4546 LFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQR 4605
            + +++         NS   + ++  +   H K   ++Q++ L    L S  +      + 
Sbjct: 1537 VSRLEARLSELEFHNSKSSKELDFLREENH-KLQLERQNLQLETRRLQSEINMAATETRD 1595

Query: 4606 LVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ--HKE 4663
            L    R++  A          WS   E  +    S D +LEI    D+++ +L     K 
Sbjct: 1596 L----RNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEI----DELQKRLGSVAVKR 1647

Query: 4664 FQKSLGAKHSVYDTTNRTGRSL 4685
             Q+    + S+      TGR L
Sbjct: 1648 EQRENHLRRSIVVIHPDTGREL 1669



 Score = 61.6 bits (148), Expect = 2e-08
 Identities = 196/1134 (17%), Positives = 447/1134 (39%), Gaps = 143/1134 (12%)

Query: 1817 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELEN---LEAGADDINGL 1873
            H    L  +++K+ + + L++ L++        E+ L Q +   E+   L++   ++  +
Sbjct: 599  HLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAM 658

Query: 1874 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1933
              +L+ QKS   +V  +              L+AAK CS     +        E Q    
Sbjct: 659  ACELQAQKSLLGEVEQN--------------LQAAKQCSSTLASRFQEHCPDLERQEAEV 704

Query: 1934 HAT-DRFRSLYSKCNVLGNNLKDLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPI 1989
            H    RF +L  +      +L+     Y+H+    D     L  + + E   +  LS+  
Sbjct: 705  HKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQ-- 762

Query: 1990 AVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIV 2049
                  ++ +L+  K L  +I+S++  V+K+   ++    A          ++  LD   
Sbjct: 763  ------METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLEN 816

Query: 2050 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 2109
            GR   +SK       +LQ   T+    +  L            + K      +N   LQ 
Sbjct: 817  GRSSHVSKRA-----RLQSPATKVKEEEAAL------------AAKFTEVYAINRQRLQ- 858

Query: 2110 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2169
                N+    ++  +Q  +   +E +++    +    A  ++ ++ + + R  +  ++ K
Sbjct: 859  ----NLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVK 914

Query: 2170 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2229
             T  ++  L+             Q   E+  +      VP   + E  Q +Q + +E  +
Sbjct: 915  STQEEIWTLRN------------QGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE-Q 961

Query: 2230 HK-----KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 2284
            HK     + LE L   L+ +        +  V+++   +    +   D + + +E + + 
Sbjct: 962  HKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEAL 1020

Query: 2285 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2344
            + Q  A +  V  L+  +    ++    Q     +++ K L++  +L+ ++     + Q+
Sbjct: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK-LQNDPQLEAEYQQLQEDHQR 1079

Query: 2345 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2404
             +         +S +    K +   ++       EG  T  E     K   + +++++D+
Sbjct: 1080 QDQLREKQEEELSFLQDKLKRLEKERA-----MAEGKITVKEVLKVEKDAAT-EREVSDL 1133

Query: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS--AMMQWLQKMNKTATKWQQTPAPTDT 2462
            +  YED     +    E    L K+   +EE++   + + ++++ +   K +   A    
Sbjct: 1134 TRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRL 1193

Query: 2463 EAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQE 2522
            E V+ Q  + +  E +L+   ++++ L+ +  + +E    T E  ++K    E++ + Q 
Sbjct: 1194 ELVE-QERKYRGAEEQLRSYQSELEALRRRGPQ-VEVKEVTKEVIKYKTD-PEMEKELQR 1250

Query: 2523 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW--LVEKELMVSVLGPLSIDPNMLNTQRQ 2580
            L +  +D+ + +E     + Q +     LK     V+ + +V  +     DP     +  
Sbjct: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDP-QTKEEVA 1309

Query: 2581 QVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPS-LRGIVKEQLAAVTQKWDSLTGQLS 2639
             ++  L E   ++   E+  A+ +  ++R  E+ S ++  V +Q     ++   L  + S
Sbjct: 1310 SLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEAS 1369

Query: 2640 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2699
               + ID  + +  + ++ LR L  + ++L+ +L              ++LE  ++ ++E
Sbjct: 1370 AFAESIDVELRQIDKLRAELRRLQRRRTELERQL--------------EELERERQARRE 1415

Query: 2700 IQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSAC 2759
             ++E       Q L + L+AL +E                     E +A   V H Q   
Sbjct: 1416 AERE------VQRLQQRLAALEQE---------------------EAEAREKVTHTQKVV 1448

Query: 2760 ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLE---SLIKDHKDFSKTLTAQSHM 2816
                Q  Q +R+        +EEQ++   +  +L+ L    + ++  +   K + ++S  
Sbjct: 1449 L--QQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQ 1506

Query: 2817 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE--KALKY 2874
             EK   E E   LK+   E++  + +L+   +  +    +++   +K  + L+  +   +
Sbjct: 1507 VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566

Query: 2875 KEQVE---------TLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMD 2919
            K Q+E          L   I+       +++       G N  ++L SL++E+D
Sbjct: 1567 KLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD 1620



 Score = 53.1 bits (126), Expect = 7e-06
 Identities = 146/848 (17%), Positives = 343/848 (40%), Gaps = 107/848 (12%)

Query: 951  LANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEH----- 1005
            L N ++   + + TL ++     +SVV    L    D +   +   ++  L  E      
Sbjct: 909  LENEVKSTQEEIWTLRNQGP--QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQL 966

Query: 1006 -QQVLSNLQSRFEDFLEDSQES-QVFSGSDITQLEKE---VNVCKQYYQELLKSAEREEQ 1060
             Q+ L  LQ +     +++++  Q +   ++ ++E +    +   Q  +EL     ++  
Sbjct: 967  LQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGA 1026

Query: 1061 EESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKEL--ER 1118
             E+   L    V  +       ++++  +    L+ D   E+ ++  +++  +++   E+
Sbjct: 1027 REAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK 1086

Query: 1119 LKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQ--NMNQVYSMSSTYIDKLKTVNL 1176
             +++L  + +K +    + A +    T++  L V        +V  ++  Y D+      
Sbjct: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARA 1146

Query: 1177 VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI-------STLKQWRSEVDEKRQVF 1229
                 +  E L K++  +  EE A +  +  +  ++       S +   R E+ E+ + +
Sbjct: 1147 --SQREKTELLRKIWALE--EENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKY 1202

Query: 1230 HALEDELQKAKAISDEMFKTYKE---RDLDFDWHKEKADQLVER-WQNVHVQIDNRLRDL 1285
               E++L+  ++  + + +   +   +++  +  K K D  +E+  Q +  +I ++ R +
Sbjct: 1203 RGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLI 1262

Query: 1286 EGIGKSLKYYRDTYHPLDDWIQQVET---TQRKIQENQPENSK----TLATQLNQQKMLV 1338
            E     +   +     L D   QV+T    Q  +Q  +   +K    +L  +L++++   
Sbjct: 1263 ERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQ 1322

Query: 1339 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1398
             ++E +++  +E     E+  + VK+  +Q    R   + +     +      S D+ ++
Sbjct: 1323 VDLERERASQEEQIARKEEELSRVKERVVQQEVVR--YEEEPGLRAEASAFAESIDVELR 1380

Query: 1399 EFMDLRTRYTALVTLMT-------------QYIKFAGDSLKRLEEEEKSLEEEKKEHVEK 1445
            +   LR     L    T             Q  + A   ++RL++   +LE+E+ E  EK
Sbjct: 1381 QIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREK 1440

Query: 1446 AKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDK 1505
                QK V       +D ++A +   +  ++  EE   +++ L   L+T++        K
Sbjct: 1441 VTHTQKVVLQ-----QDPQQARE--HALLRLQLEEEQHRRQLLEGELETLR-------RK 1486

Query: 1506 MTDEERNELEKQVKTLQESYNLLFSESLKQLQ--------ESQTSGDVKVEEKIVAERQQ 1557
            +   E+ E++++V  L ES  +   ++ +++Q        ES++  ++ VE   +  R  
Sbjct: 1487 LAALEKAEVKEKV-VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLS 1545

Query: 1558 E---YKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQAL 1614
            E   +  K     D L +  ++L             +E +  Q +   LQ ++  +A   
Sbjct: 1546 ELEFHNSKSSKELDFLREENHKL------------QLERQNLQLETRRLQSEINMAATET 1593

Query: 1615 AEVVKNTENFLKENGEKLSQEDKAL--IEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTA 1672
             ++   T   + ++G   +  D  L  +E++L++ K   +  +L+ ++ +K L  V    
Sbjct: 1594 RDLRNMT---VADSG---TNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKR 1647

Query: 1673 IKEETEKVAAV--------KQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTH 1724
             + E     ++        ++L   +     L+DW   V   S+    +   V   NG  
Sbjct: 1648 EQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGES 1707

Query: 1725 FQEGDGKS 1732
                D KS
Sbjct: 1708 SVIHDRKS 1715



 Score = 35.4 bits (80), Expect = 1.6
 Identities = 67/320 (20%), Positives = 133/320 (41%), Gaps = 57/320 (17%)

Query: 4629 KLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKE----------FQKSLGAKHSVY-- 4675
            +L E +E+ +K+ D  E  I +   K+++ LA+ +E           QK L ++  +Y  
Sbjct: 26   ELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVL 85

Query: 4676 --DTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4733
              D          +   +A+D  +L + ++ LR K   I   +V+               
Sbjct: 86   EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKE-------------- 131

Query: 4734 TDALQALIDWLYRVEPQLAE--DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4791
               +   ++W   VE +L +  +Q    D+ LV + ++ H  F  E       V+A+   
Sbjct: 132  ---VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNE-------VKAIGPH 181

Query: 4792 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4851
              +  +G ++ +S       EL  +++ + A S ++Q  L +     +++       L W
Sbjct: 182  LAK--DGDKEQNS-------ELRAKYQKLLAASQARQQHLSSL----QDYMQRCTNELYW 228

Query: 4852 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKK-LEEKRAELNKATTMGDTVLAICHPD 4910
            L +  +  R      D      +   Q++ F+ + LE K   +NK  + GD +LA  HP 
Sbjct: 229  LDQQAKG-RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPG 287

Query: 4911 SITTIKHWITIIRARFEEVL 4930
               +I+  +  + A ++E L
Sbjct: 288  R-NSIEAHMEAVHADWKEYL 306



 Score = 33.1 bits (74), Expect = 7.8
 Identities = 70/347 (20%), Positives = 138/347 (39%), Gaps = 43/347 (12%)

Query: 4275 LEERIINRQHKLEGAL-LALGQFQHALDELLAWLTHTEGLLSE--QKPVGGDPKAIEIEL 4331
            L+ER+ N + K +    LA+ +    +D  + W    E  L +   +  G D   ++ ++
Sbjct: 110  LKERVTNLRGKHKQIYRLAVKE----VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV 165

Query: 4332 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQR 4391
             +H++  N+V A           G  L +    E+ S L+ K       +Q +L  ++ R
Sbjct: 166  EEHNIFHNEVKA----------IGPHLAKDGDKEQNSELRAK-------YQKLLAASQAR 208

Query: 4392 KQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4451
            +Q L       +    E+  L Q      ++  + + L   P   ++  N    +    E
Sbjct: 209  QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLD-YPSRRRQYENF---INRNLE 264

Query: 4452 AKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKL--NERKTKLEEALN 4509
            AKEE    L  +G Q+LA        +I+  +  +   W+     L   E   K  E  +
Sbjct: 265  AKEERINKLHSEGDQLLA-AEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYH 323

Query: 4510 LAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEVNSHREQ 4565
               +FH  ++D    L + +  LN    P       ++ +L ++D+ +     ++ + + 
Sbjct: 324  ---QFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQE---KVLDKYEDV 377

Query: 4566 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4612
            +  L K G  +     +++  L K + +     +E   Q L+ RG S
Sbjct: 378  VQGLQKRGQQVVPLKYRRETPL-KPIPVEALCDFEG-EQGLISRGYS 422


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
           sapiens]
          Length = 2155

 Score =  311 bits (797), Expect = 1e-83
 Identities = 193/440 (43%), Positives = 264/440 (60%), Gaps = 27/440 (6%)

Query: 1   MAGYLSPAAYLYVEEQEY-LQAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDL 59
           ++G LSPA   Y  +  Y     E   ++ +DER+ VQKKTFTKW+N HL +V   + DL
Sbjct: 9   ISGPLSPA---YTGQVPYNYNQLEGRFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDL 65

Query: 60  YEDLRDGHNLISLLEVLSGDTLPRE-KGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDI 118
           Y DLRDG  LI LLEVLSG+ LP+  KGRMR H L+NV  AL +LK ++V L N+ + DI
Sbjct: 66  YTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDI 125

Query: 119 TDGNPKLTLGLIWTIILHFQISDIHVTGES--EDMSAKERLLLWTQQATEGYAGIRCENF 176
            DGN +LTLGLIWTIIL FQI DI V  E   E  SAK+ LLLW Q  T GY  +   NF
Sbjct: 126 VDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNF 185

Query: 177 TTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDV 235
           TT WRDG  FNA+IHK+RPDLID + +   +   NL++AF +AE+ +G+ +LLDPED+ V
Sbjct: 186 TTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISV 245

Query: 236 SSPDEKSVITYVSSLYDAFPKVPE---GGEGIGA---NDVEV-KWIE-YQNMVNYLIQWI 287
             PDEKS+ITYV + Y  F K+      G+ IG    N +E  K IE Y+++ + L++WI
Sbjct: 246 DHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWI 305

Query: 288 RHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRI 347
              +  ++ R F N+ V ++     +  ++  E PPK TEK  ++ L   ++  +     
Sbjct: 306 EQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQ 365

Query: 348 KLL---QGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKL 404
           K+    +G   +DI K W +L  A  ERE ALR E+ R E L+Q+A R  R + + E  L
Sbjct: 366 KVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWL 425

Query: 405 ILAGNALQSDSKRLESGVQF 424
                   S+++RL S   F
Sbjct: 426 --------SENQRLVSQDNF 437



 Score =  232 bits (592), Expect = 7e-60
 Identities = 339/1666 (20%), Positives = 713/1666 (42%), Gaps = 121/1666 (7%)

Query: 3278 HDLDDVNAR-------WKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVA 3330
            HD+  + AR       W+ L + +  R  +L+  L     FQ+ L  ++ WM + + LV 
Sbjct: 481  HDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVL 539

Query: 3331 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAE---PADKVKILK 3387
            +Q         V+  +Q+  L++  +  +   V  +    +K AT  E   P D   I  
Sbjct: 540  SQDY-GKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRD 598

Query: 3388 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3447
            +++ ++  ++ L   A  R  +LE    + + F E  E    W+   EK +++ +  G  
Sbjct: 599  RVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEE-EGWIREKEK-ILSSDDYGKD 656

Query: 3448 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3507
             + +   +++H+A ED++   + H  QA+  G+ + +       + ++ ++ + +  +  
Sbjct: 657  LTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDM-IAEEHFGSEKIRERIIYIREQWAN 715

Query: 3508 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSV--QDYSTEGLWKQQS 3565
            +++ S  R + L++A    + F  D  ++  W+ ++   +S   V   +YST+ L K+  
Sbjct: 716  LEQLSAIRKKRLEEASLLHQ-FQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 774

Query: 3566 ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3625
            ++    E+I   +  +D        L ++    E   ++ +L  I+ RYK++ +L+    
Sbjct: 775  DVA---EEIANYRPTLDTLHEQASALPQEHA--ESPDVRGRLSGIEERYKEVAELTRLRK 829

Query: 3626 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3685
            + L+  L L + + S  +    W+D+ E  L + +    K E+    Q R + L+ E  N
Sbjct: 830  QALQDTLALYK-MFSEADACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNN 887

Query: 3686 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3745
              + +  +N+++  L+       +E ++    + N R+    + + +K + + +A L  Q
Sbjct: 888  QASRVAVVNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA-LSIQ 945

Query: 3746 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKS 3805
             +    +   SWI E  K + S  D+  +     A  +       +++  +  + DL K 
Sbjct: 946  NYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKE 1005

Query: 3806 GHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWP 3865
              K+ +    ++ Q++  +L ++   ++ +      R   L  A  L  QF    ++   
Sbjct: 1006 AEKLESE-HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQS 1063

Query: 3866 WLTETQSIISQ--LPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE-LS 3922
            WL+ TQ+ I+   +P    E E L  Q   H  ++  I  ++    KM   G  + +  +
Sbjct: 1064 WLSRTQTAIASEDMPNTLTEAEKLLTQ---HENIKNEIDNYEEDYQKMRDMGEMVTQGQT 1120

Query: 3923 PGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD--KIDQILESLERIVE 3980
              +   ++++  A DT ++++ +  + R   L ++ +      D  + +  L + E ++ 
Sbjct: 1121 DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLA 1180

Query: 3981 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4040
                P ++      IK+Q      +  + EK+  + ET    G  +++     D +I++ 
Sbjct: 1181 HTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVET----GRRLVS-----DGNINSD 1231

Query: 4041 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFW--CDHMSLIVTIK--DTQDFIR 4096
             +Q+K+D +            E   +L D  +L +KF   C  +SL +  K    QD   
Sbjct: 1232 RIQEKVDSIDDRHRKNRETASELLMRLKDNRDL-QKFLQDCQELSLWINEKMLTAQDMSY 1290

Query: 4097 DLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSID 4156
            D E   +    +K Q   AE    +     E LD +   G +LI+   E +  +VK+ + 
Sbjct: 1291 D-EARNLHSKWLKHQAFMAELASNK-----EWLDKIEKEGMQLISEKPETEA-VVKEKLT 1343

Query: 4157 ELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLET 4216
             L+  W+ L    + +  +L +A +A + +      +  W+     ++ S    G DL +
Sbjct: 1344 GLHKMWEVLESTTQTKAQRLFDANKAEL-FTQSCADLDKWLHGLESQIQS-DDYGKDLTS 1401

Query: 4217 VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLK--KVTEESDKH--TVQDPLMELKLIW 4272
            V   +++ +  +++   ++ E+E L  QA+ L +  K T+E D    TVQ   MEL    
Sbjct: 1402 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELL--- 1458

Query: 4273 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4332
                E +  R+H L  A   + QF   +++ + W+     L +     G + + +++ + 
Sbjct: 1459 ----EPLNERKHNLL-ASKEIHQFNRDVEDEILWVGERMPLATSTDH-GHNLQTVQLLIK 1512

Query: 4333 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4392
            K+  LQ ++  HQ  ++ + +   +++  S+   A  ++ +L  L Q W  ++E+TE+R 
Sbjct: 1513 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1572

Query: 4393 QQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA 4452
            ++L+ A R A+ ++ +  + + W+++ E ++++ +      ++A   L  H  +  A E 
Sbjct: 1573 RRLEEAHR-AQQYYFDAAEAEAWMSEQELYMMSEEKAKD-EQSAVSMLKKHQILEQAVED 1630

Query: 4453 KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4512
              ET   L +  + ++A     +E  I    + + + +  ++    ER+ KL+E   L  
Sbjct: 1631 YAETVHQLSKTSRALVADSHPESE-RISMRQSKVDKLYAGLKDLAEERRGKLDERHRL-F 1688

Query: 4513 EFHNSLQDFINWLTQAEQTLNVASRPSLILD--TVLFQIDEHKVFANEV-NSHREQIIEL 4569
            + +  + D   W+ + E    VA    L  D   V    +  + FA +  N  +E++  +
Sbjct: 1689 QLNREVDDLEQWIAEREV---VAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1745

Query: 4570 DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4629
            +     L   S   D   I      +   W  +++ +  R + L  + +  K +H+A  +
Sbjct: 1746 NHLADEL-INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA-KE 1803

Query: 4630 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT 4689
            +   +++  K L  EL    D + ++T    H  F+  + A  +           L+   
Sbjct: 1804 IFGRIQDKHKKLPEEL--GRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAY 1861

Query: 4690 S--LADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRV 4747
            +   ADD  K +   +E+ + W ++      R+ +L +      +F   ++ L+ W+  V
Sbjct: 1862 AGDKADDIQKRE---NEVLEAWKSLLDACESRRVRLVDT-GDKFRFFSMVRDLMLWMEDV 1917

Query: 4748 EPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807
              Q+ E Q    D+  V  L++NH+  + E+  R  S        + L+      S  +K
Sbjct: 1918 IRQI-EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIK 1976

Query: 4808 VQMQELS-----------TRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAE 4856
             ++ +L+            RWE +         RL   + Q     SV  A   WL   E
Sbjct: 1977 EKLLQLTEKRKEMIDKWEDRWEWL---------RLILEVHQFSRDASVAEA---WLLGQE 2024

Query: 4857 QTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKRAELNKATTM 4899
              L    +     D +  LI +H+ F K     +E+ + L + TT+
Sbjct: 2025 PYLSSREI-GQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTL 2069



 Score =  214 bits (546), Expect = 1e-54
 Identities = 360/1878 (19%), Positives = 769/1878 (40%), Gaps = 161/1878 (8%)

Query: 3174 KQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQ 3233
            K+  K+LD A   E+ +E       +    +++  I+L   +      G        + Q
Sbjct: 275  KRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVG--------VQQ 326

Query: 3234 QLNMFKVFQKEEIEPL---QGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3290
            QL  F  ++  E  P    +G  + + +  Q  +++  +          + D+N  W+ L
Sbjct: 327  QLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERL 386

Query: 3291 NKKVAQRAAQLQEALLHCGRFQDALESLL-----------SWMVDTEELVANQKPPSAEF 3339
             K   +R   L+  L+     Q+ LE L            +W+ + + LV +Q     + 
Sbjct: 387  EKAEHERELALRNELIR----QEKLEQLARRFDRKAAMRETWLSENQRLV-SQDNFGFDL 441

Query: 3340 KVVKAQIQEQKLLQ---RLLDDRKSTVEVIKREGEKIATTAEPADKVK-ILKQLSLLDSR 3395
              V+A  ++ + ++      ++R   V  + RE E     AE    +K I  +   +   
Sbjct: 442  PAVEAATKKHEAIETDIAAYEERVQAVVAVARELE-----AENYHDIKRITARKDNVIRL 496

Query: 3396 WEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQI 3455
            WE LL     R ++LE +++  Q+  + +  + +W+  + K LV  +  G     +E+ +
Sbjct: 497  WEYLLELLRARRQRLE-MNLGLQKIFQEMLYIMDWMDEM-KVLVLSQDYGKHLLGVEDLL 554

Query: 3456 AQHKALEDDI-------INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEI 3508
             +H  +E DI          N    +  + G+  K      D  +++ ++   +  Y E+
Sbjct: 555  QKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPC----DPQVIRDRVAHMEFCYQEL 610

Query: 3509 QEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE--GLWKQQSE 3566
             + +  R   L+++    K F E   E   W+ E   K   LS  DY  +   + +  S+
Sbjct: 611  CQLAAERRARLEESRRLWKFFWE-MAEEEGWIRE---KEKILSSDDYGKDLTSVMRLLSK 666

Query: 3567 LRVLQEDILLRKQNVDQALLNGLELL-KQTTGDEVLIIQDKLEAIKARYKDITKLSTDVA 3625
             R  ++++  R  + +QA+  G +++ ++  G E   I++++  I+ ++ ++ +LS    
Sbjct: 667  HRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK--IRERIIYIREQWANLEQLSAIRK 724

Query: 3626 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRP-KELKKEAK 3684
            K LE+A  L  +  +  +++  W+  +++  +   + V   E ++Q+ ++  K++ +E  
Sbjct: 725  KRLEEA-SLLHQFQADADDIDAWM--LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIA 781

Query: 3685 NNKALLDSLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3742
            N +  LD+L+E +SAL    P    E   +   ++   ERY+ V++    + + +   + 
Sbjct: 782  NYRPTLDTLHEQASAL----PQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 837

Query: 3743 RSQQFDQAADAELSWITETEKKLMS------LGDIRLEQDQTSAQLQVQKTFTMEILRHK 3796
              + F +A   EL WI E E+ L +      L D+ + Q +  +           +    
Sbjct: 838  LYKMFSEADACEL-WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 896

Query: 3797 DIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQF 3856
             I   L+ SGH      SE+E   +K + DK+   +    ++   +   L  A S+ N  
Sbjct: 897  QIARQLMHSGHP-----SEKE---IKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYH 948

Query: 3857 WETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGP 3916
             E   E   W+ E   +I        +   +   Q +   +   +   +  +  + K   
Sbjct: 949  LEC-NETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAE 1007

Query: 3917 QLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 3976
            +L    P +  +I  +      ++ ++K  +K R  +L EA S+  QF   +D     L 
Sbjct: 1008 KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQQFLRDLDDFQSWLS 1066

Query: 3977 RIVERL--RQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034
            R    +     P+   E EK+   +++++N+  +++  +  Y+ ++  GE  +   G TD
Sbjct: 1067 RTQTAIASEDMPNTLTEAEKL---LTQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTD 1121

Query: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDF 4094
                   ++ +L  +   W  +H + E R+  LL      ++F  D       + + +  
Sbjct: 1122 AQY--MFLRQRLQALDTGWNELHKMWENRQ-NLLSQSHAYQQFLRDTKQAEAFLNNQEYV 1178

Query: 4095 IRDLEDP----GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4150
            +   E P    G + ++ KQ     E     +D  +E+++ V+  G  L++  G  +   
Sbjct: 1179 LAHTEMPTTLEGAEAAIKKQ-----EDFMTTMDANEEKINAVVETGRRLVSD-GNINSDR 1232

Query: 4151 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4210
            +++ +D ++       +   + + +L++        QD  Q +  W++    K+ +   +
Sbjct: 1233 IQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQD-CQELSLWIN---EKMLTAQDM 1288

Query: 4211 GTD-LETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4269
              D    +  +  + + F +E    +  ++++  +   L+ +  E   +  V++ L  L 
Sbjct: 1289 SYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPE--TEAVVKEKLTGLH 1346

Query: 4270 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4329
             +W+ LE     +  +L  A  A   F  +  +L  WL   E  + +    G D  ++ I
Sbjct: 1347 KMWEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGLESQI-QSDDYGKDLTSVNI 1404

Query: 4330 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4389
             L K  +L+N +   +  +E +      L  S  G+    + +K   +  ++  +LE   
Sbjct: 1405 LLKKQQMLENQMEVRKKEIEELQSQAQAL--SQEGKSTDEVDSKRLTVQTKFMELLEPLN 1462

Query: 4390 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAA 4449
            +RK  L  A ++   F+ ++ED   W+ +    L  S   G   +T +  +  +  +   
Sbjct: 1463 ERKHNL-LASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKE 1520

Query: 4450 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4509
             +  +     + ++ Q ++      +   I Q + +LK+ W  +  +  +R  +LEEA +
Sbjct: 1521 IQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA-H 1579

Query: 4510 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIEL 4569
             A +++    +   W+++ E  + ++   +    + +  + +H++    V  + E + +L
Sbjct: 1580 RAQQYYFDAAEAEAWMSEQELYM-MSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1638

Query: 4570 DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKV---VQRLVERGRSLDDARKRAKQFHEA 4626
             KT   L   S  +        +   QS+ +K+   ++ L E  R   D R R  Q +  
Sbjct: 1639 SKTSRALVADSHPE-----SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNRE 1693

Query: 4627 WSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLG-AKHSVYDTTNRTGRSL 4685
               L +W+ E E    S  E+  D + +     + +EF +  G       DT N     L
Sbjct: 1694 VDDLEQWIAEREVVAGSH-ELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADEL 1752

Query: 4686 -----KEKTSLADDNLKLDDMLSELRDKWDT---ICGKSVERQNKLEEALLFSGQFTDAL 4737
                  +  ++A+    L++  ++L +  DT   I   S E      +A    G+  D  
Sbjct: 1753 INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKH 1812

Query: 4738 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4797
            + L + L R             D + V  L   H  F+ ++    + V+ L+  A  L  
Sbjct: 1813 KKLPEELGR-------------DQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQA 1859

Query: 4798 G-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAE 4856
              + D +  ++ +  E+   W+++     S++ RL         F S+V  L+ W+ +  
Sbjct: 1860 AYAGDKADDIQKRENEVLEAWKSLLDACESRRVRL-VDTGDKFRFFSMVRDLMLWMEDVI 1918

Query: 4857 QTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIK 4916
            + +      P D  ++  L++ H+    +++ +         +G ++LA  H  S    +
Sbjct: 1919 RQIEAQ-EKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKE 1977

Query: 4917 HWITIIRARFEEVLAWAKQHQ-QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEV 4975
              + +   R E +  W  + +  RL   +        + E   AWL   E  L+ ++   
Sbjct: 1978 KLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAE---AWLLGQEPYLSSRE--- 2031

Query: 4976 IPQEIEEVKALIAEHQTF 4993
            I Q ++EV+ LI  H+ F
Sbjct: 2032 IGQSVDEVEKLIKRHEAF 2049



 Score =  209 bits (533), Expect = 5e-53
 Identities = 320/1645 (19%), Positives = 687/1645 (41%), Gaps = 105/1645 (6%)

Query: 3387 KQLSLLDSRWEALLNKAETRNRQL-------EGISVVAQQFHETLEPLNEWLTTIEKRLV 3439
            K +S ++  WE L      R   L       E +  +A++F         WL+   +RLV
Sbjct: 374  KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRLV 432

Query: 3440 NCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLD 3499
            + +  G     +E    +H+A+E DI  + + +   V++ + L+  +  + K +   K +
Sbjct: 433  SQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 492

Query: 3500 FSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE- 3558
              ++W   + E   +R + L+  L   KIF ++ + +M+W++E+  K+  LS QDY    
Sbjct: 493  VIRLWEY-LLELLRARRQRLEMNLGLQKIF-QEMLYIMDWMDEM--KVLVLS-QDYGKHL 547

Query: 3559 -GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTG---DEVLIIQDKLEAIKARY 3614
             G+     +  +++ DI ++ + V     +  +      G    +  +I+D++  ++  Y
Sbjct: 548  LGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCY 607

Query: 3615 KDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQM 3674
            +++ +L+ +    LE++ +L +      EE   W+ + E ++LS +          +   
Sbjct: 608  QELCQLAAERRARLEESRRLWKFFWEMAEEE-GWIREKE-KILSSDDYGKDLTSVMRLLS 665

Query: 3675 RPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKV 3734
            + +  + E        +   +    ++    + + +  E+++    +   L   +  +K 
Sbjct: 666  KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKK 725

Query: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794
               +A++L   QF   AD   +W+ +   K++S  D+  ++  T + ++  K    EI  
Sbjct: 726  RLEEASLL--HQFQADADDIDAWMLDI-LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIAN 782

Query: 3795 HKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLERAQSL 3852
            ++  +D L    H+  +A  +E  +S  ++ +L  + + Y  + ++   R   L+   +L
Sbjct: 783  YRPTLDTL----HEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLAL 838

Query: 3853 VNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMN 3912
               F E  +    W+ E +  ++ +  P  + E L   Q     L   +      +  +N
Sbjct: 839  YKMFSEA-DACELWIDEKEQWLNNMQIPE-KLEDLEVIQHRFESLEPEMNNQASRVAVVN 896

Query: 3913 KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQIL 3972
            +   QL+         I+ +    +T +SQ +E V ++  AL  A+S    +H + ++  
Sbjct: 897  QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETK 955

Query: 3973 ESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGG 4032
              +    + +     +  ++  +     +   +  D+  ++     L++  E++      
Sbjct: 956  SWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL-----E 1010

Query: 4033 TDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQ 4092
            ++    A+A+  +L ++  +WE + T ++ REA L +  +L ++F  D       +  TQ
Sbjct: 1011 SEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQ 1069

Query: 4093 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVK 4152
              I   + P       K   +  E I+ EID  +E+   + ++G  +     +     ++
Sbjct: 1070 TAIASEDMPNTLTEAEKLLTQ-HENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1128

Query: 4153 KSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT 4212
            + +  L++ W+ L+K W++R + L ++  A  Q+    +    +++     LA  + + T
Sbjct: 1129 QRLQALDTGWNELHKMWENRQNLLSQS-HAYQQFLRDTKQAEAFLNNQEYVLAH-TEMPT 1186

Query: 4213 DLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIW 4272
             LE  +  I++ + F +         E++N   E   + V   SD +   D + E     
Sbjct: 1187 TLEGAEAAIKKQEDFMT---TMDANEEKINAVVETGRRLV---SDGNINSDRIQEKV--- 1237

Query: 4273 DSLEERIINRQHKLEGALLA------LGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKA 4326
            DS+++R    +      L+       L +F     EL  W+   E +L+ Q     + + 
Sbjct: 1238 DSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWI--NEKMLTAQDMSYDEARN 1295

Query: 4327 IEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLE 4386
            +  +  KH     ++ +++  ++ + K G  LI      EA  ++ KL  L++ W+ VLE
Sbjct: 1296 LHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAV-VKEKLTGLHKMWE-VLE 1353

Query: 4387 KTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA---SKPLGGLPETAKEQLNVH 4443
             T Q K Q      +A+ F     DL +WL   E  + +    K L  +    K+Q  + 
Sbjct: 1354 STTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLE 1413

Query: 4444 MEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTK 4503
             ++    +  EE     +Q   Q L++  KS +  +D     ++ K+  +   LNERK  
Sbjct: 1414 NQMEVRKKEIEE-----LQSQAQALSQEGKSTD-EVDSKRLTVQTKFMELLEPLNERKHN 1467

Query: 4504 LEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHR 4563
            L  +  +  +F+  ++D I W+ +    L  ++     L TV   I +++    E+  H+
Sbjct: 1468 LLASKEI-HQFNRDVEDEILWVGE-RMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQ 1525

Query: 4564 EQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQF 4623
             +I ++ +   ++   S       I+  L  ++  W  +++   +R R L++A  RA+Q+
Sbjct: 1526 PRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAH-RAQQY 1584

Query: 4624 HEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGR 4683
            +   ++   W+ E E  + SE E A D     + L +H+  ++++          ++T R
Sbjct: 1585 YFDAAEAEAWMSEQELYMMSE-EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSR 1643

Query: 4684 SL-----KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEA-LLFSGQFTDAL 4737
            +L      E   ++    K+D + + L+D        + ER+ KL+E   LF  Q    +
Sbjct: 1644 ALVADSHPESERISMRQSKVDKLYAGLKD-------LAEERRGKLDERHRLF--QLNREV 1694

Query: 4738 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELI 4796
              L  W+   E  +A    +  D + V  L +  + F ++ G      V  +   A ELI
Sbjct: 1695 DDLEQWIAERE-VVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1753

Query: 4797 EGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAE 4856
                 D++ +      L+  W  +  L I  +T++ AA   + E H   H   E     +
Sbjct: 1754 NSGHSDAATIAEWKDGLNEAWADLLEL-IDTRTQILAA---SYELHKFYHDAKEIFGRIQ 1809

Query: 4857 QTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSI 4912
                 H  LP+    D++ + TL   H  F   ++    ++ +       + A    D  
Sbjct: 1810 DK---HKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKA 1866

Query: 4913 TTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKD 4972
              I+     +   ++ +L   +  + RL         K      +   + W E  +   +
Sbjct: 1867 DDIQKRENEVLEAWKSLLDACESRRVRLVDT----GDKFRFFSMVRDLMLWMEDVIRQIE 1922

Query: 4973 KEVIPQEIEEVKALIAEHQTFMEEM 4997
             +  P+++  V+ L+  HQ    E+
Sbjct: 1923 AQEKPRDVSSVELLMNNHQGIKAEI 1947



 Score =  162 bits (409), Expect = 1e-38
 Identities = 251/1319 (19%), Positives = 543/1319 (41%), Gaps = 103/1319 (7%)

Query: 3745 QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR------HKDI 3798
            ++++  A   L WI +T   ++ L + +        Q Q+Q   T   +        K  
Sbjct: 292  EKYESLASDLLEWIEQT---IIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGN 348

Query: 3799 IDDLVKSGHKIMTACSEEEKQSMKKKL-DKVLKNYDTICQINSERYLQL-------ERAQ 3850
            ++ L+ +    M A +++     + KL   + K ++ + +   ER L L       E+ +
Sbjct: 349  LEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLE 408

Query: 3851 SLVNQFWETYEELWPWLTETQSIISQ----LPAPALEYETLRQQQEEHRQLRELIAEHKP 3906
             L  +F         WL+E Q ++SQ       PA+E  T     ++H  +   IA ++ 
Sbjct: 409  QLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT-----KKHEAIETDIAAYEE 463

Query: 3907 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3966
             +  +     +L   +  +   I  +      L+  + E ++ R   L+  +     F +
Sbjct: 464  RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 523

Query: 3967 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026
             +  I++ ++ + + L         +  +++ + ++  V  D+       +  + RG   
Sbjct: 524  ML-YIMDWMDEM-KVLVLSQDYGKHLLGVEDLLQKHTLVEADIG-----IQAERVRGVNA 576

Query: 4027 IARSGGTD----KDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHM 4082
             A+   TD    K    + ++D++  M F ++ +  L  ER A+L +   L + FW    
Sbjct: 577  SAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFW---- 632

Query: 4083 SLIVTIKDTQDFIRDLE------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLG 4136
                 + + + +IR+ E      D G D + V +         +E+ G     +  I  G
Sbjct: 633  ----EMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 688

Query: 4137 SELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDW 4196
             ++IA      + I ++ I  +   W +L +    R  +LEEA     Q+Q     +  W
Sbjct: 689  EDMIAEEHFGSEKI-RERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAW 746

Query: 4197 V-DIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEE 4255
            + DI   K+ S S +G D  + +  +++ K    E    +  ++ L+ QA  L ++  E 
Sbjct: 747  MLDIL--KIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAES 804

Query: 4256 SDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLS 4315
             D   V+  L  ++  +  + E    R+  L+  L     F  A D    W+   E  L+
Sbjct: 805  PD---VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA-DACELWIDEKEQWLN 860

Query: 4316 EQKPVGGDPKAIE-IELAKHHV--LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4372
              +     P+ +E +E+ +H    L+ ++    S V  VN+    L+ S    E   ++ 
Sbjct: 861  NMQI----PEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE-KEIKA 915

Query: 4373 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLG-- 4430
            + + LN RW    E  +++K  L  AL   + +H E  + + W+ +  + + +++ LG  
Sbjct: 916  QQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIREKTKVIESTQDLGND 974

Query: 4431 --GLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKE 4488
              G+    ++   +  ++  A EAK      L ++ +++ +  P  A+  + + +  + +
Sbjct: 975  LAGVMALQRKLTGMERDL-VAIEAK---LSDLQKEAEKLESEHPDQAQAILSR-LAEISD 1029

Query: 4489 KWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ 4548
             WE ++T L  R+  L EA  L  +F   L DF +WL++ +  +     P+ + +     
Sbjct: 1030 VWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKL- 1087

Query: 4549 IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVE 4608
            + +H+   NE++++ E   ++   G  +         + ++  L ++ + W ++  ++ E
Sbjct: 1088 LTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNEL-HKMWE 1146

Query: 4609 RGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSL 4668
              ++L       +QF     +   +L   E  L +  E+    +  +  + + ++F  ++
Sbjct: 1147 NRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-AHTEMPTTLEGAEAAIKKQEDFMTTM 1205

Query: 4669 GAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728
             A     +    TGR L     ++D N+  D     +++K D+I  +  + +    E L+
Sbjct: 1206 DANEEKINAVVETGRRL-----VSDGNINSD----RIQEKVDSIDDRHRKNRETASELLM 1256

Query: 4729 FSGQFTDALQALIDW----LYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSS 4784
                  D  + L D     L+  E  L      + +   + +    H+AF  EL      
Sbjct: 1257 RLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEW 1316

Query: 4785 VQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSV 4844
            +  +++   +LI    +  + VK ++  L   WE + + + +K  RL  A  +AE F   
Sbjct: 1317 LDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA-NKAELFTQS 1375

Query: 4845 VHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL 4904
               L +WL   E  ++       D  ++  L+ + +    ++E ++ E+ +  +    + 
Sbjct: 1376 CADLDKWLHGLESQIQSDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALS 1434

Query: 4905 AICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWA 4964
                  S   +      ++ +F E+L    + +  L ++       +++ + +L W+   
Sbjct: 1435 Q--EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL-WVGER 1491

Query: 4965 ETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQS 5023
                T  D       ++ V+ LI ++QT  +E+   QP +D + +  +    D SSL +
Sbjct: 1492 MPLATSTDHG---HNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1547



 Score =  149 bits (375), Expect = 1e-34
 Identities = 333/1806 (18%), Positives = 719/1806 (39%), Gaps = 200/1806 (11%)

Query: 1471 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1530
            FSK K  + E     + L  A++T ++      +K      + LE   +T+    N  F+
Sbjct: 264  FSKMKALAVEGKRIGKVLDNAIETEKMI-----EKYESLASDLLEWIEQTIIILNNRKFA 318

Query: 1531 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1586
             SL    +QLQ   T   V        E+  ++ EK      L T        +Q+ +M 
Sbjct: 319  NSLVGVQQQLQAFNTYRTV--------EKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMP 370

Query: 1587 GDGTV---------ELKKYQSKQE-----EL--QKDMQGSAQALAEVVKNTENFLKENGE 1630
             +G +          L+K + ++E     EL  Q+ ++  A+         E +L EN  
Sbjct: 371  REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 430

Query: 1631 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1690
             +SQ++       +  A  K E +       ++ +  VV  A + E E    +K++   K
Sbjct: 431  LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 490

Query: 1691 TKIENLLDWLSNVDKDSERAGTKHKQVIEQN-GTHFQEGDGKSAIGEEDEVNGNLLETDV 1749
              +  L ++L  + +         +Q +E N G      +    +   DE+   +L  D 
Sbjct: 491  DNVIRLWEYLLELLR-------ARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 543

Query: 1750 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1809
             G+     E+L Q++  V+A    I  Q + V     SAQ      G+   P + + ++ 
Sbjct: 544  -GKHLLGVEDLLQKHTLVEAD---IGIQAERVRGVNASAQ-KFATDGEGYKPCDPQVIRD 598

Query: 1810 NMKELKVHY-ETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1868
             +  ++  Y E     +E++ +L  S    L KF  +  E E W+++ E+ L + + G  
Sbjct: 599  RVAHMEFCYQELCQLAAERRARLEES--RRLWKFFWEMAEEEGWIREKEKILSSDDYG-K 655

Query: 1869 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1928
            D+  +M  L + ++F +++    G        G  ++      S++             +
Sbjct: 656  DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEK-------------I 702

Query: 1929 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SE 1987
            + ++ +  +++ +L     +    L++    +Q   DA       + A      K + S 
Sbjct: 703  RERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD-----DIDAWMLDILKIVSSS 757

Query: 1988 PIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDD 2047
             +  D  + Q  +++ K +  +I++ +  ++ L + A  L            D++  L  
Sbjct: 758  DVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAE----SPDVRGRLSG 813

Query: 2048 IVGRYEDLSKSVNERNEKLQITLT--RSLSVQDG----LDEMLDWMGNVESSLKEQGQVP 2101
            I  RY+++++    R + LQ TL   +  S  D     +DE   W+ N+        Q+P
Sbjct: 814  IEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNM--------QIP 865

Query: 2102 LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPS--TASSLQAKMKDLSA 2159
                 L+ I  +   LE ++  + S +  +N+  ++ M +  PS     + Q K+    +
Sbjct: 866  EKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWS 925

Query: 2160 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQY 2219
            +F E   + K+ L         ++ +     + ++++  KT+ +      G D+  +   
Sbjct: 926  QFRELVDRKKDALLS----ALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMAL 981

Query: 2220 MQESTS---EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2276
             ++ T    + +  +  L  L    +++ S   P     +L +   +S  ++EM+ T+K 
Sbjct: 982  QRKLTGMERDLVAIEAKLSDLQKEAEKLESEH-PDQAQAILSRLAEISDVWEEMKTTLK- 1039

Query: 2277 KKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWS 2336
             +EA      +L  F   +   +SW+  T       Q +  +ED+  +L + +KL  +  
Sbjct: 1040 NREASLGEASKLQQFLRDLDDFQSWLSRT-------QTAIASEDMPNTLTEAEKLLTQHE 1092

Query: 2337 LKTPEI-------QKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW 2389
                EI       QK+ + G     +++   T A+ +   +   A+  G        + W
Sbjct: 1093 NIKNEIDNYEEDYQKMRDMG----EMVTQGQTDAQYMFLRQRLQALDTG---WNELHKMW 1145

Query: 2390 ANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKT 2449
             N      ++++   SH Y+      K   A LN +   L                    
Sbjct: 1146 EN------RQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVL-------------------- 1179

Query: 2450 ATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW 2509
                  T  PT  E  +  +++ + F   +  N  K+  + +    L+ +      + R 
Sbjct: 1180 ----AHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDG--NINSDRI 1233

Query: 2510 KQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLS 2569
            ++ +  ID + ++  +   +   +L++ + +L +F     +L  W+ EK L       +S
Sbjct: 1234 QEKVDSIDDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINEKMLTAQ---DMS 1289

Query: 2570 ID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2628
             D    L+++  + Q  + E A+ K   +++   G  ++S   E P    +VKE+L  + 
Sbjct: 1290 YDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLIS---EKPETEAVVKEKLTGLH 1346

Query: 2629 QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQ 2688
            + W+ L      +   +  A  K+  +      L   L  L++++ S         ++N 
Sbjct: 1347 KMWEVLESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTSVNI 1404

Query: 2689 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKA 2748
             L+  Q ++ +++  KK+I+  Q+  +   AL +E     E+  +   +   F ++ +  
Sbjct: 1405 LLKKQQMLENQMEVRKKEIEELQSQAQ---ALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1461

Query: 2749 ENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2808
             N  +H   A    HQF +   D   W+  ++     S      L  ++ LIK ++   K
Sbjct: 1462 -NERKHNLLASKEIHQFNRDVEDEILWVG-ERMPLATSTDHGHNLQTVQLLIKKNQTLQK 1519

Query: 2809 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2868
             +       +      +N++  +      A++ +L  +K  W    ++ ++R  +L+E+ 
Sbjct: 1520 EIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEA- 1578

Query: 2869 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELL 2928
             +A +Y         W+ + +  +   +   D     + + K + L++ ++ +   V  L
Sbjct: 1579 HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQL 1638

Query: 2929 NNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 2988
            + T+ +L++    + E ++     + +    + +    ++  L+   + F+  +EV  + 
Sbjct: 1639 SKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREV--DD 1696

Query: 2989 KRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSL-----QALKHQVDLAKRLAQDLV 3043
              Q    +E +     LG Q Y  +++TMLQ + +          + +VD    LA +L+
Sbjct: 1697 LEQWIAEREVVAGSHELG-QDY--EHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1753

Query: 3044 VEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ------GIGHFQNTIREM 3097
                 + G SD      TIA+    L++   +    ++T+ Q       +  F +  +E+
Sbjct: 1754 -----NSGHSD----AATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEI 1804

Query: 3098 FSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA--T 3155
            F +  +   +L     +GRD  T++  +     F   ++AL        +    + A   
Sbjct: 1805 FGRIQDKHKKLPE--ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYA 1862

Query: 3156 EETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE 3215
             + + D+   KR+ E L +    LLD  ++R  ++  T  +   F+S +++  + ++   
Sbjct: 1863 GDKADDIQ--KRENEVL-EAWKSLLDACESRRVRLVDTGDKF-RFFSMVRDLMLWMEDVI 1918

Query: 3216 EHEESQ 3221
               E+Q
Sbjct: 1919 RQIEAQ 1924



 Score =  137 bits (345), Expect = 3e-31
 Identities = 280/1593 (17%), Positives = 637/1593 (39%), Gaps = 158/1593 (9%)

Query: 3502 QVWYIEIQEKSHSRSELLQQAL---CNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3558
            Q+  I ++ + +   +  + AL   C  K  G   V + N+     D ++  ++      
Sbjct: 145  QIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNAL------ 198

Query: 3559 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEA--------- 3609
             + K + +L    +   L+K N    L N   L +Q  G   L+  + +           
Sbjct: 199  -IHKHRPDLIDFDK---LKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSII 254

Query: 3610 --IKARYKDITKLST------DVAKTLEQALQ---LARRLHSTHEELCTWLDKVEVELLS 3658
              +   Y   +K+         + K L+ A++   +  +  S   +L  W+++  + L +
Sbjct: 255  TYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNN 314

Query: 3659 --YETQVLKGEEASQAQMRPKELKKEAK-----NNKALLDSLNEVSSALLELVPWRAREG 3711
              +   ++  ++  QA    + ++K  K     N + LL ++     A  + V +  REG
Sbjct: 315  RKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKV-YMPREG 373

Query: 3712 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQ-------FDQAADAELSWITETEKK 3764
              K++++ N+ +  +     ++   +   ++R ++       FD+ A    +W++E ++ 
Sbjct: 374  --KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR- 430

Query: 3765 LMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKK 3824
            L+S  +   +     A  +  +    +I  +++ +  +V    ++      + K+   +K
Sbjct: 431  LVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARK 490

Query: 3825 LDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSII--SQLPAPAL 3882
             D V++ ++ + ++   R  +LE    L   F E    +  W+ E + ++         L
Sbjct: 491  -DNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLY-IMDWMDEMKVLVLSQDYGKHLL 548

Query: 3883 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFS------IQEKYVAA 3936
              E L Q+   H  +   I      +  +N +  +    + GEG+       I+++    
Sbjct: 549  GVEDLLQK---HTLVEADIGIQAERVRGVNASAQKFA--TDGEGYKPCDPQVIRDRVAHM 603

Query: 3937 DTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 3996
            +  Y ++ +   +R   L+E+      F +  ++  E   R  E++        ++  + 
Sbjct: 604  EFCYQELCQLAAERRARLEESRRLWKFFWEMAEE--EGWIREKEKILSSDDYGKDLTSVM 661

Query: 3997 EQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENI 4056
              +S+++    +M      +E   + GE+MIA     ++   ++ +++++  +   W N+
Sbjct: 662  RLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIA-----EEHFGSEKIRERIIYIREQWANL 716

Query: 4057 HTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAE 4116
              L   R+ K L+   L  +F  D   +   + D    +    D G D    +   +  +
Sbjct: 717  EQLSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSS-SDVGHDEYSTQSLVKKHK 774

Query: 4117 TIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKL 4176
             + EEI   +  LD +    S L     E   P V+  +  +   +  + +  + R   L
Sbjct: 775  DVAEEIANYRPTLDTLHEQASALPQEHAE--SPDVRGRLSGIEERYKEVAELTRLRKQAL 832

Query: 4177 EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGT--DLETVKQQIEELK-----QFKS 4229
            ++ +     + +   A   W+D     L +M       DLE ++ + E L+     Q   
Sbjct: 833  QDTLALYKMFSEA-DACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASR 891

Query: 4230 EAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4289
             A   QI  + L H      K++  + DK         L   W    E +  ++  L  A
Sbjct: 892  VAVVNQIARQ-LMHSGHPSEKEIKAQQDK---------LNTRWSQFRELVDRKKDALLSA 941

Query: 4290 LLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVE 4349
            L ++  +    +E  +W+     ++   + +G D   +     K   ++ D++A ++ + 
Sbjct: 942  L-SIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLS 1000

Query: 4350 AVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEI 4409
             + K    L ES   ++A  + ++L  ++  W+ +    + R+  L G   + + F  ++
Sbjct: 1001 DLQKEAEKL-ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASL-GEASKLQQFLRDL 1058

Query: 4410 EDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLA 4469
            +D Q WL+ T+   +AS+ +      A++ L  H  +    +  EE Y+ +   G+ +  
Sbjct: 1059 DDFQSWLSRTQT-AIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV-- 1115

Query: 4470 RCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAE 4529
                  +   D     L+++ ++++T  NE     E   NL  + H + Q F+    QAE
Sbjct: 1116 -----TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSH-AYQQFLRDTKQAE 1169

Query: 4530 QTLN------VASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQ 4583
              LN        +     L+     I + + F   ++++ E+I  + +TG  L       
Sbjct: 1170 AFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL-VSDGNI 1228

Query: 4584 DVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDS 4643
            +   I+  + S+  R  K  +   E    L D R   K F +   +L  W+  +EK L +
Sbjct: 1229 NSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK-FLQDCQELSLWI--NEKMLTA 1285

Query: 4644 ELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLS 4703
            +    ++   + ++  +H+ F   L +     D   + G  L  +    +  +K  + L+
Sbjct: 1286 QDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVK--EKLT 1343

Query: 4704 ELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DID 4762
             L   W+ +   +  +  +L +A   +  FT +   L  WL+ +E Q+  D   +G D+ 
Sbjct: 1344 GLHKMWEVLESTTQTKAQRLFDANK-AELFTQSCADLDKWLHGLESQIQSDD--YGKDLT 1400

Query: 4763 LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCA 4822
             V  L+   +  + ++  R   ++ L+  A+ L   S++  S  +V  + L+ + + +  
Sbjct: 1401 SVNILLKKQQMLENQMEVRKKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMEL 1457

Query: 4823 LS-ISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQ--TLRFHGVLPDDEDALRTLIDQH 4879
            L  ++++     A ++  +F+  V   + W+ E     T   HG    +   ++ LI ++
Sbjct: 1458 LEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHG---HNLQTVQLLIKKN 1514

Query: 4880 KEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQR 4939
            +   K+++  +  ++        ++      S   I+  +  ++  +  ++   ++  +R
Sbjct: 1515 QTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRR 1574

Query: 4940 LASALAGLIAKQELLEALLAWLQWAETTLTDKDK--------------EVIPQEIEEV-- 4983
            L  A        +  EA  AW+   E  +  ++K              +++ Q +E+   
Sbjct: 1575 LEEAHRAQQYYFDAAEAE-AWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAE 1633

Query: 4984 ---------KALIAEHQTFMEEMTRKQPDVDKV 5007
                     +AL+A+     E ++ +Q  VDK+
Sbjct: 1634 TVHQLSKTSRALVADSHPESERISMRQSKVDKL 1666



 Score =  130 bits (326), Expect = 5e-29
 Identities = 345/1826 (18%), Positives = 720/1826 (39%), Gaps = 221/1826 (12%)

Query: 2021 KKTAEVLLDARGSLLPAKNDIQ------KTLDDIVGRYEDLSKSVNERNEKLQITLTRSL 2074
            K   EVLL    S + A N         K + DI   +E L K+ +ER   L+  L R  
Sbjct: 346  KGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQE 405

Query: 2075 SVQ------DGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSI 2128
             ++      D    M +   +    L  Q     +  A++    K+  +E DIA  +  +
Sbjct: 406  KLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERV 465

Query: 2129 NAMNEKVKKFMETTDPSTASSLQAK----MKDLSARFSEASHKHKETLAKMEELKTKVEL 2184
             A+             + A  L+A+    +K ++AR        +  L  +   + ++E+
Sbjct: 466  QAV------------VAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEM 513

Query: 2185 FENLSEKLQTFL-------ETKTQALTEVDVPGKDVTELSQYMQEST---SEFLEHKKHL 2234
               L +  Q  L       E K   L++    GK +  +   +Q+ T   ++     + +
Sbjct: 514  NLGLQKIFQEMLYIMDWMDEMKVLVLSQDY--GKHLLGVEDLLQKHTLVEADIGIQAERV 571

Query: 2235 EVLHSLLKEISSHG---LPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2291
              +++  ++ ++ G    P D  ++ ++  ++   ++E+     E++  +   +     F
Sbjct: 572  RGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFF 631

Query: 2292 QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2351
              + +  + WI+E  K +        ++D GK L    +L  K      E+     SG  
Sbjct: 632  WEMAEE-EGWIREKEKIL-------SSDDYGKDLTSVMRLLSKHRAFEDEMS--GRSG-- 679

Query: 2352 LCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDL 2411
              +   A+      IA    G   +          E WAN                 E L
Sbjct: 680  --HFEQAIKEGEDMIAEEHFGSEKIRER--IIYIREQWAN----------------LEQL 719

Query: 2412 GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2471
              + K ++ E     S L + Q ++  +  W+  + K  +    +    D  + ++ V++
Sbjct: 720  SAIRKKRLEEA----SLLHQFQADADDIDAWMLDILKIVSS---SDVGHDEYSTQSLVKK 772

Query: 2472 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQ 2531
            +K    E+      +  L ++ + L +E+ ++P+    +  L+ I+ +++E+ +LT  R+
Sbjct: 773  HKDVAEEIANYRPTLDTLHEQASALPQEHAESPDV---RGRLSGIEERYKEVAELTRLRK 829

Query: 2532 QKLEESSNNLTQFQTVEAQLKQWLVEKELMVS------VLGPL--------SIDPNMLNT 2577
            Q L+++      F   +A  + W+ EKE  ++       L  L        S++P M N 
Sbjct: 830  QALQDTLALYKMFSEADA-CELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEM-NN 887

Query: 2578 QRQQV----QILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDS 2633
            Q  +V    QI  Q   +  P  +++ A    + +R  +   L          V +K D+
Sbjct: 888  QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL----------VDRKKDA 937

Query: 2634 LTGQLSDRCDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVSTHPDAMNQQL 2690
            L   LS     I    ++  + +S +R  +   +   DL N L+  +A+      M + L
Sbjct: 938  LLSALS-----IQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDL 992

Query: 2691 ETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAEN 2750
               +    ++Q+E ++++               +  +A LSR     L    DV ++ + 
Sbjct: 993  VAIEAKLSDLQKEAEKLESEHP-----------DQAQAILSR-----LAEISDVWEEMKT 1036

Query: 2751 HVQHLQSACASSHQFQQMSRD---FQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFS 2807
             +++ +++   + + QQ  RD   FQ+WL ++ +    S  +   L   E L+  H++  
Sbjct: 1037 TLKNREASLGEASKLQQFLRDLDDFQSWL-SRTQTAIASEDMPNTLTEAEKLLTQHENIK 1095

Query: 2808 KTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKES 2867
              +      Y+K    GE +      ++   L+ +L  + T W+  +K  + R+N L +S
Sbjct: 1096 NEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQS 1155

Query: 2868 --LEKALKYKEQVETLWPWIDKCQNNLE------EIKFCLDPAEGENSIAKLKSLQKEMD 2919
               ++ L+  +Q E          NN E      E+   L+ AE   +I K +     MD
Sbjct: 1156 HAYQQFLRDTKQAEAF-------LNNQEYVLAHTEMPTTLEGAEA--AIKKQEDFMTTMD 1206

Query: 2920 QHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2979
             +   +  +  T   L+S   I+ + +        +KVD + ++    +     +  + K
Sbjct: 1207 ANEEKINAVVETGRRLVSDGNINSDRIQ-------EKVDSIDDRHRKNRETASELLMRLK 1259

Query: 2980 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3039
            + +++ K  +    C +  L I++ +     + + ++  + +    + LKHQ  +A+  +
Sbjct: 1260 DNRDLQKFLQ---DCQELSLWINEKM----LTAQDMSYDEARNLHSKWLKHQAFMAELAS 1312

Query: 3040 QDLVVEASDSKGTSDVLLQVET---IAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIRE 3096
                ++  + +G   +  + ET   + ++ + L +  +   S  +TK Q +  F     E
Sbjct: 1313 NKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL--FDANKAE 1370

Query: 3097 MFSQ-FAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMM--- 3152
            +F+Q  A+ D  L  +      ++   K   ++   LKK + L    +   K  + +   
Sbjct: 1371 LFTQSCADLDKWLHGLES-QIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQ 1429

Query: 3153 ---LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSI 3209
               L+ E  S D V  KR    +  +  +LL+    R+  +  + K + +F   +++  I
Sbjct: 1430 AQALSQEGKSTDEVDSKR--LTVQTKFMELLEPLNERKHNLLAS-KEIHQFNRDVED-EI 1485

Query: 3210 LLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK 3269
            L         +    G   +T+   +   +  QK EI+  Q +  D+    Q ++  ++ 
Sbjct: 1486 LWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQK-EIQGHQPRIDDIFERSQNIVTDSS- 1543

Query: 3270 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3329
            S S + +   L D+   W  L ++  +R  +L+EA      + DA E+  +WM + E  +
Sbjct: 1544 SLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA-EAWMSEQELYM 1602

Query: 3330 ANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQL 3389
             +++    E   V + +++ ++L++ ++D   TV  + +    +   + P +  +I  + 
Sbjct: 1603 MSEEKAKDEQSAV-SMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP-ESERISMRQ 1660

Query: 3390 SLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQAS 3449
            S +D  +  L + AE R  +L+    +  Q +  ++ L +W+   E  +     +G    
Sbjct: 1661 SKVDKLYAGLKDLAEERRGKLDERHRLF-QLNREVDDLEQWIAEREV-VAGSHELGQDYE 1718

Query: 3450 KLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQ 3509
             +     + +    D  N  +     V+      + S   D   +    D     + ++ 
Sbjct: 1719 HVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLL 1778

Query: 3510 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYST-EGLWKQQSELR 3568
            E   +R+++L  A      F  D  E+   + + H KL +   +D +T E L +  +   
Sbjct: 1779 ELIDTRTQIL-AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHT--- 1834

Query: 3569 VLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTL 3628
              + DI      V Q   +   L     GD+   IQ +   +   +K +          L
Sbjct: 1835 TFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRL 1894

Query: 3629 EQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKA 3688
                    R  S   +L  W++ V  ++ + E    K  + S  ++    L    +  KA
Sbjct: 1895 VDTGD-KFRFFSMVRDLMLWMEDVIRQIEAQE----KPRDVSSVEL----LMNNHQGIKA 1945

Query: 3689 LLDSLN-------EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAI 3741
             +D+ N       E+  +LL    + + E  EK++    +R  ++ D    + E +   I
Sbjct: 1946 EIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMI-DKWEDRWEWL-RLI 2003

Query: 3742 LRSQQFDQAADAELSWITETEKKLMS 3767
            L   QF + A    +W+   E  L S
Sbjct: 2004 LEVHQFSRDASVAEAWLLGQEPYLSS 2029



 Score =  104 bits (259), Expect = 3e-21
 Identities = 314/1692 (18%), Positives = 646/1692 (38%), Gaps = 220/1692 (13%)

Query: 1183 AAEALVKLYETK--------LCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALED 1234
            AAE   +L E++        + EEE  I +K  I +     K   S V        A ED
Sbjct: 614  AAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS-VMRLLSKHRAFED 672

Query: 1235 ELQKAKAISDEMFKTYKERDLDFDWHKEKADQLV----ERWQNVHVQIDNRLRDLEGIGK 1290
            E+       ++  K  ++   +  +  EK  + +    E+W N+      R + LE    
Sbjct: 673  EMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASL 732

Query: 1291 SLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQ--LNQQKMLVSEIEMKQSKM 1348
              ++  D    +D W+  +     KI  +        +TQ  + + K +  EI   +  +
Sbjct: 733  LHQFQADA-DDIDAWMLDI----LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTL 787

Query: 1349 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYT 1408
            D   + A                  A+     +SP  R R+    +   +     R R  
Sbjct: 788  DTLHEQAS-----------------ALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQ 830

Query: 1409 ALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGK 1468
            AL   +  Y  F+      L  +EK       +  EK ++L+         ++   ++ +
Sbjct: 831  ALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE--------VIQHRFESLE 882

Query: 1469 PPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLL 1528
            P  + Q      ++    QL  +    +  +    DK+ +   ++  + V   +++    
Sbjct: 883  PEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKL-NTRWSQFRELVDRKKDALLSA 941

Query: 1529 FSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGD 1588
             S     L+ ++T   ++ + K++ E  Q+    L G+  L    + +L G +   +  +
Sbjct: 942  LSIQNYHLECNETKSWIREKTKVI-ESTQDLGNDLAGVMAL----QRKLTGMERDLVAIE 996

Query: 1589 GTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAK 1648
               +L   Q + E+L+ +    AQA+   +    +  +E    L   + +L E       
Sbjct: 997  A--KLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS----- 1049

Query: 1649 IKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSE 1708
             K +Q     +  +  L +  T    E+      + + E+  T+ EN+ + + N ++D +
Sbjct: 1050 -KLQQFLRDLDDFQSWLSRTQTAIASEDMPNT--LTEAEKLLTQHENIKNEIDNYEEDYQ 1106

Query: 1709 RAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVK 1768
            +      +++ Q  T  Q    +  +   D     L +   + Q   +Q +  QQ+ +  
Sbjct: 1107 KMRDMG-EMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDT 1165

Query: 1769 AQHEKIISQHQAVIIATQ------SAQVLLEKQGQYLSP----EEK-------------- 1804
             Q E  ++  + V+  T+       A+  ++KQ  +++     EEK              
Sbjct: 1166 KQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSD 1225

Query: 1805 -----EKLQKNMKELKV-HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQ 1858
                 +++Q+ +  +   H +     SE  M+L  +   +L+KF  D  E   W+  +E+
Sbjct: 1226 GNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDN--RDLQKFLQDCQELSLWI--NEK 1281

Query: 1859 ELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1918
             L   +   D+   L +K  + ++F  ++ S+K  L  I   G +++            K
Sbjct: 1282 MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISE----------K 1331

Query: 1919 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1978
             +T A    V+ KL      +  L S        L D  +K + +  +   L   L   E
Sbjct: 1332 PETEAV---VKEKLTGLHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCADLDKWLHGLE 1387

Query: 1979 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2038
               S+  S+    D  ++   L++ + L+ Q+  ++  +E+L+  A+ L     S     
Sbjct: 1388 ---SQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKST---- 1440

Query: 2039 NDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQG 2098
            +++      +  ++ +L + +NER   L  +       +D  DE+L W+G     L    
Sbjct: 1441 DEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEIL-WVGE-RMPLATST 1498

Query: 2099 QVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLS 2158
                N   +Q +I KN  L+++I G Q  I+ + E+ +  +  +   +A +++ ++ DL 
Sbjct: 1499 DHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLK 1558

Query: 2159 ARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQ 2218
              +     + ++   ++EE     + + + +E      E +   ++E     K   E S 
Sbjct: 1559 QLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSE----EKAKDEQSA 1614

Query: 2219 YMQESTSEFLEH--KKHLEVLHSLLKEISSHGLPSD----KALVLEKTNNLSKKFKEMED 2272
                   + LE   + + E +H L K  +S  L +D       +  + + + K +  ++D
Sbjct: 1615 VSMLKKHQILEQAVEDYAETVHQLSK--TSRALVADSHPESERISMRQSKVDKLYAGLKD 1672

Query: 2273 TIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQ 2332
              +E++  +   + +L      V  L+ WI E        +   G+ +LG+  E    LQ
Sbjct: 1673 LAEERRGKLDE-RHRLFQLNREVDDLEQWIAER-------EVVAGSHELGQDYEHVTMLQ 1724

Query: 2333 EKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2387
            E++     +   +    +   N     LI++  + A  IA  K G   LN E  A   E 
Sbjct: 1725 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDG---LN-EAWADLLEL 1780

Query: 2388 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMN 2447
                  + +   ++    H  +++   ++DK  +L  +L + Q   E        LQ+M+
Sbjct: 1781 IDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVET-------LQRMH 1833

Query: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNV--NKVQELKDKLTELLEENPDTPE 2505
             T           D +A+ TQV Q +   A L+     +K  +++ +  E+LE       
Sbjct: 1834 TTFEH--------DIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE------- 1878

Query: 2506 APRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVL 2565
               WK +L   +S           R+ +L ++ +    F  V   L  W+ E  +     
Sbjct: 1879 --AWKSLLDACES-----------RRVRLVDTGDKFRFFSMVR-DLMLWM-EDVIRQIEA 1923

Query: 2566 GPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2625
                 D + +       Q +  E   R   +      G+ +L+R          +KE+L 
Sbjct: 1924 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASE---EIKEKLL 1980

Query: 2626 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDA 2685
             +T+K   +  +  DR +W+ + I++  Q+              D  ++ +  +   P  
Sbjct: 1981 QLTEKRKEMIDKWEDRWEWL-RLILEVHQFSR------------DASVAEAWLLGQEP-- 2025

Query: 2686 MNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745
                  +++++ Q + + +K IK  +A  E  +A   E +   E    LE      +   
Sbjct: 2026 ----YLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLE----LLEVRR 2076

Query: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPI-----SAKLDVLESLI 2800
            Q+ E   +    +   S +  + +   Q W DT K EQ   + +     S ++       
Sbjct: 2077 QQEEEERKRRPPSPEPSTKVSEEAESQQQW-DTSKGEQVSQNGLPAEQGSPRVSYRSQTY 2135

Query: 2801 KDHKDFSKTLTA 2812
            +++K+F+   TA
Sbjct: 2136 QNYKNFNSRRTA 2147



 Score = 95.9 bits (237), Expect = 1e-18
 Identities = 277/1494 (18%), Positives = 572/1494 (38%), Gaps = 238/1494 (15%)

Query: 579  LKLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHL 638
            L+L++ R+  L+ +L  Q + +E   M ++ D   W+DEM+V +   ++G  L  VE  L
Sbjct: 501  LELLRARRQRLEMNLGLQKIFQE---MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLL 554

Query: 639  ENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAE------------KLHRLESQYAK 686
            + H  V     E +  ++  ++  +  +A    T  E            ++  +E  Y +
Sbjct: 555  QKHTLV-----EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQE 609

Query: 687  LLNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAE 743
            L   +  +   L+    L  F      E  W+ EKE+   + D+ +  T++ R    H  
Sbjct: 610  LCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRA 669

Query: 744  LMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKE 803
               E+  +  + +   +  E ++ E H     I      ++ QW+ + QL    ++ ++E
Sbjct: 670  FEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEE 729

Query: 804  NTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKST 863
             +   +F  DA +   ++ ++   +    S D     +  + LV++  +  EE+  Y+ T
Sbjct: 730  ASLLHQFQADADDIDAWMLDILKIVS---SSDVGHDEYSTQSLVKKHKDVAEEIANYRPT 786

Query: 864  IANLMGKAKTIIQ--------------LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDD 909
            +  L  +A  + Q              ++ R  +    T +  +A+ D   +     + D
Sbjct: 787  LDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEAD 846

Query: 910  ECVL--------ANNSH-----------RAKWKVISPTGNE-----AMVPSVC----FTV 941
             C L         NN             + +++ + P  N      A+V  +      + 
Sbjct: 847  ACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSG 906

Query: 942  PPPNKE---AVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDR-IRASNVASI 997
             P  KE     D  N    Q++ ++    ++ ++  S+ ++H   NE    IR       
Sbjct: 907  HPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIE 966

Query: 998  KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQE-----LL 1052
             T   G     +  LQ +    L   +   V   + ++ L+KE    +  + +     L 
Sbjct: 967  STQDLGNDLAGVMALQRK----LTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILS 1022

Query: 1053 KSAE----REEQEESVYN--LYISEVRNIRLRLENCED--RLIRQIRTPLERDD----LH 1100
            + AE     EE + ++ N    + E   ++  L + +D    + + +T +  +D    L 
Sbjct: 1023 RLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLT 1082

Query: 1101 ESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQV 1160
            E+   +T+ E +K E++  ++D   + +   E  +Q    +    LR  L  +    N++
Sbjct: 1083 EAEKLLTQHENIKNEIDNYEEDYQKMRD-MGEMVTQGQTDAQYMFLRQRLQALDTGWNEL 1141

Query: 1161 YSM---SSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQ 1217
            + M       + +       L++T+ AEA +   E  L   E           + +TL+ 
Sbjct: 1142 HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-----------MPTTLEG 1190

Query: 1218 WRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQ 1277
              + + ++      ++   +K  A+ +   +   + +++ D  +EK D + +R +     
Sbjct: 1191 AEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRET 1250

Query: 1278 IDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKML 1337
                L  L+   + L+ +      L  WI +   T    Q+   + ++ L ++  + +  
Sbjct: 1251 ASELLMRLKD-NRDLQKFLQDCQELSLWINEKMLT---AQDMSYDEARNLHSKWLKHQAF 1306

Query: 1338 VSEIEMKQSKMDECQKYAEQY-------SATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ 1390
            ++E+   +  +D+ +K   Q         A VK+          +++S  ++  +R    
Sbjct: 1307 MAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDA 1366

Query: 1391 SSADLIIQEFMDLRTRYTALVTLMTQYIKFAGD--SLKRLEEEEKSLEEEKKEHVEKAKE 1448
            + A+L  Q   DL  ++   +    Q   +  D  S+  L ++++ LE + +   ++ +E
Sbjct: 1367 NKAELFTQSCADL-DKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE 1425

Query: 1449 LQKWVSNISKTLKDAEKAGK-------------PPFSKQK---ISSEEISTKKEQLSEA- 1491
            LQ     +S+  K  ++                 P +++K   ++S+EI      + +  
Sbjct: 1426 LQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEI 1485

Query: 1492 ------------------LQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESL 1533
                              LQT+QL + K+           L+K+++  Q   + +F  S 
Sbjct: 1486 LWVGERMPLATSTDHGHNLQTVQLLIKKN---------QTLQKEIQGHQPRIDDIFERSQ 1536

Query: 1534 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGD---GT 1590
              + +S +     + +++   +Q      L G+  L+ +TE R    +EA          
Sbjct: 1537 NIVTDSSSLSAEAIRQRLADLKQ------LWGL--LIEETEKRHRRLEEAHRAQQYYFDA 1588

Query: 1591 VELKKYQSKQ------EELQKDMQGSAQALA--EVVKNTENFLKENGEKLSQEDKALIEQ 1642
             E + + S+Q      EE  KD Q +   L   ++++       E   +LS+  +AL+  
Sbjct: 1589 AEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVAD 1648

Query: 1643 KLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLS- 1701
               E+    E+++++  +  K L   +    +E   K+    +L +   ++++L  W++ 
Sbjct: 1649 SHPES----ERISMRQSKVDK-LYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAE 1703

Query: 1702 -NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENL 1760
              V   S   G  ++ V     T  QE        E     GN+ +  VD       E +
Sbjct: 1704 REVVAGSHELGQDYEHV-----TMLQE-----RFREFARDTGNIGQERVDTVNHLADELI 1753

Query: 1761 NQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPE-EKEKLQKNMKELKVHYE 1819
            N  +         I      +  A      L++ + Q L+   E  K   + KE+    +
Sbjct: 1754 NSGHSDAAT----IAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ 1809

Query: 1820 TALAESEKKMKLTHSL---QEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1876
                  +K  KL   L   Q  +E     +T FEH +Q    ++  L+  A         
Sbjct: 1810 ------DKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDA--------- 1854

Query: 1877 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKS----CSKRDGGKVDTSATHR 1926
             + Q +++ D    K D   I    N VLEA KS    C  R    VDT    R
Sbjct: 1855 ARLQAAYAGD----KAD--DIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFR 1902



 Score = 53.1 bits (126), Expect = 7e-06
 Identities = 52/281 (18%), Positives = 116/281 (41%), Gaps = 28/281 (9%)

Query: 593 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIE 649
           +LD  +  E++  K+     DLL W+++  + L+  ++ + L  V+  L+   N +R +E
Sbjct: 280 VLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAF-NTYRTVE 338

Query: 650 EFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRAT 709
           +     ++  +  +  T   K+    +   +  +   + + ++  ER     H       
Sbjct: 339 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 398

Query: 710 NELIWLNEKEEEEVAYD--------WSERNTNIARKKDY-------------HAELMREL 748
           NELI   + E+    +D        W   N  +  + ++             H  +  ++
Sbjct: 399 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDI 458

Query: 749 DQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYF 808
              EE +++V  +A +L  EN+     I A +  +   W ++L+L +   Q ++ N    
Sbjct: 459 AAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQ 518

Query: 809 EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 849
           + F +     D++  +K  +    S D    +  +EDL+Q+
Sbjct: 519 KIFQEMLYIMDWMDEMKVLV---LSQDYGKHLLGVEDLLQK 556


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.128    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 189,621,257
Number of Sequences: 37866
Number of extensions: 8365728
Number of successful extensions: 63665
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 208
Number of HSP's successfully gapped in prelim test: 1270
Number of HSP's that attempted gapping in prelim test: 32828
Number of HSP's gapped (non-prelim): 15783
length of query: 5497
length of database: 18,247,518
effective HSP length: 125
effective length of query: 5372
effective length of database: 13,514,268
effective search space: 72598647696
effective search space used: 72598647696
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 74 (33.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.