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Search of human proteins with 34452723
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34452723 gamma-aminobutyric acid A receptor, alpha 4
precursor [Homo sapiens]
(554 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso... 1105 0.0
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs... 577 e-165
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor... 510 e-144
gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 487 e-137
gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 487 e-137
gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 487 e-137
gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 487 e-137
gi|189083726 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 487 e-137
gi|189083724 gamma-aminobutyric acid (GABA) A receptor, alpha 1 ... 487 e-137
gi|38327554 gamma-aminobutyric acid (GABA) A receptor, alpha 1 p... 487 e-137
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr... 479 e-135
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s... 477 e-134
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs... 477 e-134
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 367 e-101
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ... 367 e-101
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso... 367 e-101
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ... 351 1e-96
gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform... 346 3e-95
gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon p... 304 2e-82
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p... 274 2e-73
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso... 273 4e-73
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is... 270 3e-72
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is... 268 1e-71
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso... 268 1e-71
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens] 263 4e-70
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens] 261 9e-70
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens] 261 9e-70
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens] 261 9e-70
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens] 261 1e-69
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo... 256 4e-68
>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
[Homo sapiens]
Length = 554
Score = 1105 bits (2859), Expect = 0.0
Identities = 554/554 (100%), Positives = 554/554 (100%)
Query: 1 MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD 60
MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD
Sbjct: 1 MVSAKKVPAIALSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYD 60
Query: 61 NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN 120
NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN
Sbjct: 61 NRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLN 120
Query: 121 NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP 180
NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP
Sbjct: 121 NMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFP 180
Query: 181 MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT 240
MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT
Sbjct: 181 MDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSIT 240
Query: 241 GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT 300
GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT
Sbjct: 241 GEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMT 300
Query: 301 TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ 360
TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ
Sbjct: 301 TLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQ 360
Query: 361 EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES 420
EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES
Sbjct: 361 EVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQES 420
Query: 421 SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG 480
SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG
Sbjct: 421 SKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFG 480
Query: 481 SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV 540
SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV
Sbjct: 481 SRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVV 540
Query: 541 YLSKDTMEKSESLM 554
YLSKDTMEKSESLM
Sbjct: 541 YLSKDTMEKSESLM 554
>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
[Homo sapiens]
Length = 453
Score = 577 bits (1488), Expect = e-165
Identities = 286/374 (76%), Positives = 323/374 (86%), Gaps = 2/374 (0%)
Query: 21 LRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYV 80
L +LC+ + L + G+ + E +EN +RILD+LL+GYDNRLRPGFGG VTEVKTDIYV
Sbjct: 5 LPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYV 64
Query: 81 TSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKS 140
TSFGPVSDVEMEYTMDVFFRQTW D+RLK+ GP EIL LNN+MV+K+WTPDTFFRNGKKS
Sbjct: 65 TSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKS 124
Query: 141 VSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEM 200
++HNMT PNKLFRIM+NGTILYTMRLTI+A+CPMRLV+FPMDGHACPLKFGSYAYPKSE+
Sbjct: 125 IAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEI 184
Query: 201 IYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFM 260
IYTW KGP SVEVP+ESSSL+QYDLIGQTVSSETIKS TGEY++MTVYFHL+RKMGYFM
Sbjct: 185 IYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFM 244
Query: 261 IQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMD 320
IQ Y PCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMD
Sbjct: 245 IQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMD 304
Query: 321 WFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTS-KPPQEVPAAPVQREKHPEAPLQN 379
WFIAVCFAFVFSALIEFAAVNYFTN+Q +KAKRK P V + E L +
Sbjct: 305 WFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVL-H 363
Query: 380 TNANLNMRKRTNAL 393
++ +++KR +L
Sbjct: 364 PDSKYHLKKRITSL 377
Score = 77.4 bits (189), Expect = 3e-14
Identities = 43/87 (49%), Positives = 54/87 (62%), Gaps = 5/87 (5%)
Query: 467 KASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILF 526
K + S S V S ++ T + +T TPPP +P + GTSKID+Y+RILF
Sbjct: 371 KKRITSLSLPIVSSSEANKVLTRAPILQST---PVTPPPLSP--AFGGTSKIDQYSRILF 425
Query: 527 PVTFGAFNMVYWVVYLSKDTMEKSESL 553
PV F FN+VYWVVYLSKDTME S S+
Sbjct: 426 PVAFAGFNLVYWVVYLSKDTMEVSSSV 452
>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
[Homo sapiens]
Length = 492
Score = 510 bits (1313), Expect = e-144
Identities = 273/503 (54%), Positives = 334/503 (66%), Gaps = 84/503 (16%)
Query: 48 FTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKR 107
FTRILD LLDGYDNRLRPG G VTEVKTDIYVTSFGPVSD +MEYT+DVFFRQTW D+R
Sbjct: 67 FTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDER 126
Query: 108 LKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLT 167
LK+DGP++IL LNN++ +K+WTPDTFF NGKKSV+HNMT PNKL R++ NGT+LYTMRLT
Sbjct: 127 LKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLT 186
Query: 168 ISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLI 227
I AECPM L DFPMD HACPLKFGSYAY +E++Y+WT G KSVEV ++ S L QYDL+
Sbjct: 187 IHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGSRLNQYDLL 246
Query: 228 GQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPA 287
G V +E I+S TGEY+VMT +FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPA
Sbjct: 247 GHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 306
Query: 288 RTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQ 347
RTVFG+TTVLTMTTLSISAR+SLPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 307 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT--- 363
Query: 348 MEKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVG 407
KR + ++VP A L M+K+T A
Sbjct: 364 ----KRSWAWEGKKVPEA------------------LEMKKKTPAAP------------- 388
Query: 408 NHSSKSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAAR-ALPSASPTSIRTGYMPR 466
+ K+ST + + P + A E + ++ A PSAS T
Sbjct: 389 --AKKTSTTFN----------IVGTTYPINLAKDTEFSTISKGAAPSASSTP-------- 428
Query: 467 KASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILF 526
TI A+ K + + + SK+DK +RI+F
Sbjct: 429 -------------------------TIIASPKATYVQDSPTETKTYNSVSKVDKISRIIF 463
Query: 527 PVTFGAFNMVYWVVYLSKDTMEK 549
PV F FN+VYW Y+++++ K
Sbjct: 464 PVLFAIFNLVYWATYVNRESAIK 486
>gi|189083734 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 487 bits (1253), Expect = e-137
Identities = 237/335 (70%), Positives = 281/335 (83%), Gaps = 3/335 (0%)
Query: 13 SAGVSFALLRF-LCLAVCLNESPGQNQKEEKLC--TENFTRILDSLLDGYDNRLRPGFGG 69
S G+S L + L L+ S GQ +++L T FTRILD LLDGYDNRLRPG G
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGE 63
Query: 70 PVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWT 129
VTEVKTDI+VTSFGPVSD +MEYT+DVFFRQ+W D+RLK+ GP+ +LRLNN+M +K+WT
Sbjct: 64 RVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWT 123
Query: 130 PDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLK 189
PDTFF NGKKSV+HNMT PNKL RI +GT+LYTMRLT+ AECPM L DFPMD HACPLK
Sbjct: 124 PDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLK 183
Query: 190 FGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVY 249
FGSYAY ++E++Y WT+ P +SV V ++ S L QYDL+GQTV S ++S TGEY+VMT +
Sbjct: 184 FGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTH 243
Query: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309
FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPARTVFG+TTVLTMTTLSISAR+S
Sbjct: 244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNS 303
Query: 310 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT 344
LPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 304 LPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT 338
Score = 49.7 bits (117), Expect = 7e-06
Identities = 22/49 (44%), Positives = 32/49 (65%), Gaps = 1/49 (2%)
Query: 502 TPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKS 550
T PP P + + SKID+ +RI FP+ FG FN+VYW YL+++ K+
Sbjct: 404 TKPPE-PKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKA 451
>gi|189083732 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 487 bits (1253), Expect = e-137
Identities = 237/335 (70%), Positives = 281/335 (83%), Gaps = 3/335 (0%)
Query: 13 SAGVSFALLRF-LCLAVCLNESPGQNQKEEKLC--TENFTRILDSLLDGYDNRLRPGFGG 69
S G+S L + L L+ S GQ +++L T FTRILD LLDGYDNRLRPG G
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGE 63
Query: 70 PVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWT 129
VTEVKTDI+VTSFGPVSD +MEYT+DVFFRQ+W D+RLK+ GP+ +LRLNN+M +K+WT
Sbjct: 64 RVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWT 123
Query: 130 PDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLK 189
PDTFF NGKKSV+HNMT PNKL RI +GT+LYTMRLT+ AECPM L DFPMD HACPLK
Sbjct: 124 PDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLK 183
Query: 190 FGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVY 249
FGSYAY ++E++Y WT+ P +SV V ++ S L QYDL+GQTV S ++S TGEY+VMT +
Sbjct: 184 FGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTH 243
Query: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309
FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPARTVFG+TTVLTMTTLSISAR+S
Sbjct: 244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNS 303
Query: 310 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT 344
LPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 304 LPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT 338
Score = 49.7 bits (117), Expect = 7e-06
Identities = 22/49 (44%), Positives = 32/49 (65%), Gaps = 1/49 (2%)
Query: 502 TPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKS 550
T PP P + + SKID+ +RI FP+ FG FN+VYW YL+++ K+
Sbjct: 404 TKPPE-PKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKA 451
>gi|189083730 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 487 bits (1253), Expect = e-137
Identities = 237/335 (70%), Positives = 281/335 (83%), Gaps = 3/335 (0%)
Query: 13 SAGVSFALLRF-LCLAVCLNESPGQNQKEEKLC--TENFTRILDSLLDGYDNRLRPGFGG 69
S G+S L + L L+ S GQ +++L T FTRILD LLDGYDNRLRPG G
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGE 63
Query: 70 PVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWT 129
VTEVKTDI+VTSFGPVSD +MEYT+DVFFRQ+W D+RLK+ GP+ +LRLNN+M +K+WT
Sbjct: 64 RVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWT 123
Query: 130 PDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLK 189
PDTFF NGKKSV+HNMT PNKL RI +GT+LYTMRLT+ AECPM L DFPMD HACPLK
Sbjct: 124 PDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLK 183
Query: 190 FGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVY 249
FGSYAY ++E++Y WT+ P +SV V ++ S L QYDL+GQTV S ++S TGEY+VMT +
Sbjct: 184 FGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTH 243
Query: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309
FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPARTVFG+TTVLTMTTLSISAR+S
Sbjct: 244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNS 303
Query: 310 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT 344
LPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 304 LPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT 338
Score = 49.7 bits (117), Expect = 7e-06
Identities = 22/49 (44%), Positives = 32/49 (65%), Gaps = 1/49 (2%)
Query: 502 TPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKS 550
T PP P + + SKID+ +RI FP+ FG FN+VYW YL+++ K+
Sbjct: 404 TKPPE-PKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKA 451
>gi|189083728 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 487 bits (1253), Expect = e-137
Identities = 237/335 (70%), Positives = 281/335 (83%), Gaps = 3/335 (0%)
Query: 13 SAGVSFALLRF-LCLAVCLNESPGQNQKEEKLC--TENFTRILDSLLDGYDNRLRPGFGG 69
S G+S L + L L+ S GQ +++L T FTRILD LLDGYDNRLRPG G
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGE 63
Query: 70 PVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWT 129
VTEVKTDI+VTSFGPVSD +MEYT+DVFFRQ+W D+RLK+ GP+ +LRLNN+M +K+WT
Sbjct: 64 RVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWT 123
Query: 130 PDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLK 189
PDTFF NGKKSV+HNMT PNKL RI +GT+LYTMRLT+ AECPM L DFPMD HACPLK
Sbjct: 124 PDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLK 183
Query: 190 FGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVY 249
FGSYAY ++E++Y WT+ P +SV V ++ S L QYDL+GQTV S ++S TGEY+VMT +
Sbjct: 184 FGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTH 243
Query: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309
FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPARTVFG+TTVLTMTTLSISAR+S
Sbjct: 244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNS 303
Query: 310 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT 344
LPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 304 LPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT 338
Score = 49.7 bits (117), Expect = 7e-06
Identities = 22/49 (44%), Positives = 32/49 (65%), Gaps = 1/49 (2%)
Query: 502 TPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKS 550
T PP P + + SKID+ +RI FP+ FG FN+VYW YL+++ K+
Sbjct: 404 TKPPE-PKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKA 451
>gi|189083726 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 487 bits (1253), Expect = e-137
Identities = 237/335 (70%), Positives = 281/335 (83%), Gaps = 3/335 (0%)
Query: 13 SAGVSFALLRF-LCLAVCLNESPGQNQKEEKLC--TENFTRILDSLLDGYDNRLRPGFGG 69
S G+S L + L L+ S GQ +++L T FTRILD LLDGYDNRLRPG G
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGE 63
Query: 70 PVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWT 129
VTEVKTDI+VTSFGPVSD +MEYT+DVFFRQ+W D+RLK+ GP+ +LRLNN+M +K+WT
Sbjct: 64 RVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWT 123
Query: 130 PDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLK 189
PDTFF NGKKSV+HNMT PNKL RI +GT+LYTMRLT+ AECPM L DFPMD HACPLK
Sbjct: 124 PDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLK 183
Query: 190 FGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVY 249
FGSYAY ++E++Y WT+ P +SV V ++ S L QYDL+GQTV S ++S TGEY+VMT +
Sbjct: 184 FGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTH 243
Query: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309
FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPARTVFG+TTVLTMTTLSISAR+S
Sbjct: 244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNS 303
Query: 310 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT 344
LPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 304 LPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT 338
Score = 49.7 bits (117), Expect = 7e-06
Identities = 22/49 (44%), Positives = 32/49 (65%), Gaps = 1/49 (2%)
Query: 502 TPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKS 550
T PP P + + SKID+ +RI FP+ FG FN+VYW YL+++ K+
Sbjct: 404 TKPPE-PKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKA 451
>gi|189083724 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 487 bits (1253), Expect = e-137
Identities = 237/335 (70%), Positives = 281/335 (83%), Gaps = 3/335 (0%)
Query: 13 SAGVSFALLRF-LCLAVCLNESPGQNQKEEKLC--TENFTRILDSLLDGYDNRLRPGFGG 69
S G+S L + L L+ S GQ +++L T FTRILD LLDGYDNRLRPG G
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGE 63
Query: 70 PVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWT 129
VTEVKTDI+VTSFGPVSD +MEYT+DVFFRQ+W D+RLK+ GP+ +LRLNN+M +K+WT
Sbjct: 64 RVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWT 123
Query: 130 PDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLK 189
PDTFF NGKKSV+HNMT PNKL RI +GT+LYTMRLT+ AECPM L DFPMD HACPLK
Sbjct: 124 PDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLK 183
Query: 190 FGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVY 249
FGSYAY ++E++Y WT+ P +SV V ++ S L QYDL+GQTV S ++S TGEY+VMT +
Sbjct: 184 FGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTH 243
Query: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309
FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPARTVFG+TTVLTMTTLSISAR+S
Sbjct: 244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNS 303
Query: 310 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT 344
LPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 304 LPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT 338
Score = 49.7 bits (117), Expect = 7e-06
Identities = 22/49 (44%), Positives = 32/49 (65%), Gaps = 1/49 (2%)
Query: 502 TPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKS 550
T PP P + + SKID+ +RI FP+ FG FN+VYW YL+++ K+
Sbjct: 404 TKPPE-PKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKA 451
>gi|38327554 gamma-aminobutyric acid (GABA) A receptor, alpha 1
precursor [Homo sapiens]
Length = 456
Score = 487 bits (1253), Expect = e-137
Identities = 237/335 (70%), Positives = 281/335 (83%), Gaps = 3/335 (0%)
Query: 13 SAGVSFALLRF-LCLAVCLNESPGQNQKEEKLC--TENFTRILDSLLDGYDNRLRPGFGG 69
S G+S L + L L+ S GQ +++L T FTRILD LLDGYDNRLRPG G
Sbjct: 4 SPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPGLGE 63
Query: 70 PVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWT 129
VTEVKTDI+VTSFGPVSD +MEYT+DVFFRQ+W D+RLK+ GP+ +LRLNN+M +K+WT
Sbjct: 64 RVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWT 123
Query: 130 PDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLK 189
PDTFF NGKKSV+HNMT PNKL RI +GT+LYTMRLT+ AECPM L DFPMD HACPLK
Sbjct: 124 PDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLK 183
Query: 190 FGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVY 249
FGSYAY ++E++Y WT+ P +SV V ++ S L QYDL+GQTV S ++S TGEY+VMT +
Sbjct: 184 FGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTH 243
Query: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309
FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPARTVFG+TTVLTMTTLSISAR+S
Sbjct: 244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNS 303
Query: 310 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT 344
LPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 304 LPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT 338
Score = 49.7 bits (117), Expect = 7e-06
Identities = 22/49 (44%), Positives = 32/49 (65%), Gaps = 1/49 (2%)
Query: 502 TPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKS 550
T PP P + + SKID+ +RI FP+ FG FN+VYW YL+++ K+
Sbjct: 404 TKPPE-PKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKA 451
>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
precursor [Homo sapiens]
Length = 462
Score = 479 bits (1234), Expect = e-135
Identities = 223/297 (75%), Positives = 262/297 (88%)
Query: 48 FTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKR 107
FTRILD LLDGYDNRLRPG G +T+V+TDIYVTSFGPVSD EMEYT+DVFFRQ+W D+R
Sbjct: 49 FTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDER 108
Query: 108 LKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLT 167
L++ GP++ L LNN++ +K+WTPDTFF NGKKS++HNMT PNKL R+ +GT+LYTMRLT
Sbjct: 109 LRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLT 168
Query: 168 ISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLI 227
ISAECPM+L DFPMD HACPLKFGSYAYP SE++Y WT G KSV V ++ S L QY L+
Sbjct: 169 ISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLM 228
Query: 228 GQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPA 287
GQTV +E I + TGEY +MT +FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPA
Sbjct: 229 GQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 288
Query: 288 RTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT 344
RTVFG+TTVLTMTTLSISAR+SLPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 289 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT 345
Score = 50.4 bits (119), Expect = 4e-06
Identities = 26/61 (42%), Positives = 35/61 (57%), Gaps = 5/61 (8%)
Query: 494 GATGKLSATPPPSAPPPSGS-----GTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTME 548
G + S + PS S S SKIDK +RI+FPV FG FN+VYW YL+++ +
Sbjct: 396 GTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVI 455
Query: 549 K 549
K
Sbjct: 456 K 456
>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
sapiens]
Length = 451
Score = 477 bits (1227), Expect = e-134
Identities = 225/297 (75%), Positives = 257/297 (86%)
Query: 48 FTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKR 107
FTRILD LLDGYDNRLRPG G +TEV T+IYVTSFGPVSD +MEYT+DVFFRQ W D+R
Sbjct: 42 FTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDER 101
Query: 108 LKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLT 167
LK+ GP+ ILRLNN+M +K+WTPDTFF NGKKSV+HNMT PNKL RI +GT+LYTMRLT
Sbjct: 102 LKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLT 161
Query: 168 ISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLI 227
+ AECPM L DFPMD H+CPLKFGSYAY SE+ Y WT SV+V + S L QYDL+
Sbjct: 162 VQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLL 221
Query: 228 GQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPA 287
GQ++ ETIKS TGEY VMT +FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPA
Sbjct: 222 GQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 281
Query: 288 RTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT 344
RTVFG+TTVLTMTTLSISAR+SLPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 282 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT 338
Score = 50.8 bits (120), Expect = 3e-06
Identities = 23/61 (37%), Positives = 35/61 (57%), Gaps = 8/61 (13%)
Query: 493 IGATGKLSATPPPSAPPPSG--------SGTSKIDKYARILFPVTFGAFNMVYWVVYLSK 544
+ K + TP P+ P + + SKID+ +RI+FPV FG FN+VYW YL++
Sbjct: 384 LSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNR 443
Query: 545 D 545
+
Sbjct: 444 E 444
>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
[Homo sapiens]
Length = 451
Score = 477 bits (1227), Expect = e-134
Identities = 225/297 (75%), Positives = 257/297 (86%)
Query: 48 FTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKR 107
FTRILD LLDGYDNRLRPG G +TEV T+IYVTSFGPVSD +MEYT+DVFFRQ W D+R
Sbjct: 42 FTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDER 101
Query: 108 LKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLT 167
LK+ GP+ ILRLNN+M +K+WTPDTFF NGKKSV+HNMT PNKL RI +GT+LYTMRLT
Sbjct: 102 LKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLT 161
Query: 168 ISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLI 227
+ AECPM L DFPMD H+CPLKFGSYAY SE+ Y WT SV+V + S L QYDL+
Sbjct: 162 VQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLL 221
Query: 228 GQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPA 287
GQ++ ETIKS TGEY VMT +FHL+RK+GYF+IQTY+PCIMTVILSQVSFW+N+ESVPA
Sbjct: 222 GQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 281
Query: 288 RTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFT 344
RTVFG+TTVLTMTTLSISAR+SLPKV+YATAMDWFIAVC+AFVFSALIEFA VNYFT
Sbjct: 282 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFT 338
Score = 50.8 bits (120), Expect = 3e-06
Identities = 23/61 (37%), Positives = 35/61 (57%), Gaps = 8/61 (13%)
Query: 493 IGATGKLSATPPPSAPPPSG--------SGTSKIDKYARILFPVTFGAFNMVYWVVYLSK 544
+ K + TP P+ P + + SKID+ +RI+FPV FG FN+VYW YL++
Sbjct: 384 LSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNR 443
Query: 545 D 545
+
Sbjct: 444 E 444
>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
precursor [Homo sapiens]
Length = 467
Score = 367 bits (943), Expect = e-101
Identities = 183/336 (54%), Positives = 242/336 (72%), Gaps = 10/336 (2%)
Query: 49 TRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRL 108
T IL++LL+GYDN+LRP G T + TD+YV S GPV+ + MEYT+D+FF QTW D+RL
Sbjct: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
Query: 109 KYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTI 168
K++ I++LRLN+ MV K+W PDTFFRN KK+ +H +T PN++ RI +G +LYT+RLTI
Sbjct: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
Query: 169 SAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEV-PKESSSLVQYDLI 227
AEC ++L +FPMD H+CPL+F SY YP+ E++Y W + SVEV S L Q+ +
Sbjct: 187 DAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKR---SSVEVGDTRSWRLYQFSFV 243
Query: 228 GQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPA 287
G ++E +K+ +G+Y+VM+VYF L R+MGYF IQTYIPC + V+LS VSFWINK++VPA
Sbjct: 244 GLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPA 303
Query: 288 RTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYF-TNI 346
RT GITTVLTMTTLS AR SLPKVSY TAMD F++VCF FVFSAL+E+ ++YF +N
Sbjct: 304 RTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNR 363
Query: 347 QMEKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTNA 382
+ K K K K P AP + A +Q NA
Sbjct: 364 KPSKDKDKKKKNP-----APTIDIRPRSATIQMNNA 394
Score = 42.0 bits (97), Expect = 0.001
Identities = 17/27 (62%), Positives = 20/27 (74%)
Query: 516 SKIDKYARILFPVTFGAFNMVYWVVYL 542
+K+D YARI FP F FN+VYWV YL
Sbjct: 439 AKMDSYARIFFPTAFCLFNLVYWVSYL 465
>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
precursor [Homo sapiens]
Length = 475
Score = 367 bits (943), Expect = e-101
Identities = 182/347 (52%), Positives = 245/347 (70%), Gaps = 13/347 (3%)
Query: 49 TRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRL 108
T IL++LL+GYDN+LRP G T + TD+YV S GPV+ + MEYT+D+FF QTW D+RL
Sbjct: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
Query: 109 KYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTI 168
K++ I++LRLN+ MV K+W PDTFFRN KK+ +H +T PN++ RI +G +LYT+RLTI
Sbjct: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
Query: 169 SAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEV-PKESSSLVQYDLI 227
AEC ++L +FPMD H+CPL+F SY YP+ E++Y W + SVEV S L Q+ +
Sbjct: 187 DAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKR---SSVEVGDTRSWRLYQFSFV 243
Query: 228 GQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPA 287
G ++E +K+ +G+Y+VM+VYF L R+MGYF IQTYIPC + V+LS VSFWINK++VPA
Sbjct: 244 GLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPA 303
Query: 288 RTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQ 347
RT GITTVLTMTTLS AR SLPKVSY TAMD F++VCF FVFSAL+E+ ++YF
Sbjct: 304 RTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV--- 360
Query: 348 MEKAKRKTSKPPQEVPAAPVQRE---KHPEAPLQNTNANLNMRKRTN 391
+ RK SK + P+ R K P ++ +A + M T+
Sbjct: 361 ---SNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATH 404
Score = 42.0 bits (97), Expect = 0.001
Identities = 17/27 (62%), Positives = 20/27 (74%)
Query: 516 SKIDKYARILFPVTFGAFNMVYWVVYL 542
+K+D YARI FP F FN+VYWV YL
Sbjct: 447 AKMDSYARIFFPTAFCLFNLVYWVSYL 473
>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
[Homo sapiens]
Length = 465
Score = 367 bits (943), Expect = e-101
Identities = 185/370 (50%), Positives = 251/370 (67%), Gaps = 12/370 (3%)
Query: 20 LLRFLCLAVCLNESPGQNQKE----------EKLCTENFTRILDSLLDGYDNRLRPGFGG 69
LL L L C++++ ++ ++ K+ + T+IL+SLL GYDN+LRP G
Sbjct: 26 LLLTLHLGNCVDKADDEDDEDLTVNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGV 85
Query: 70 PVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWT 129
T ++TD+YV S GPV + MEYT+D+ F QTW D RLK++ +++L LN+ MV K+W
Sbjct: 86 RPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWI 145
Query: 130 PDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLK 189
PDTFFRN +KS +H +T PN+L RI +G +LYT+RLTI+AEC ++L +FPMD H+CPL+
Sbjct: 146 PDTFFRNSRKSDAHWITTPNRLLRIWNDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLE 205
Query: 190 FGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVY 249
F SY YPK+E+ Y W K P V PK L Q+ +G S+E +I+G+Y++MT++
Sbjct: 206 FSSYGYPKNEIEYKWKK-PSVEVADPK-YWRLYQFAFVGLRNSTEITHTISGDYVIMTIF 263
Query: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309
F L R+MGYF IQTYIPCI+TV+LS VSFWINK++VPART GITTVLTMTTLS AR S
Sbjct: 264 FDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKS 323
Query: 310 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQR 369
LPKVSY TAMD F++VCF FVF+AL+E+ ++YFT+ Q K K K + P
Sbjct: 324 LPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNQKGKTATKDRKLKNKASMTPGLH 383
Query: 370 EKHPEAPLQN 379
P+ N
Sbjct: 384 PGSTLIPMNN 393
Score = 42.7 bits (99), Expect = 9e-04
Identities = 17/27 (62%), Positives = 20/27 (74%)
Query: 516 SKIDKYARILFPVTFGAFNMVYWVVYL 542
+KID Y+RI FP F FN+VYWV YL
Sbjct: 437 AKIDSYSRIFFPTAFALFNLVYWVGYL 463
>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
[Homo sapiens]
Length = 467
Score = 351 bits (900), Expect = 1e-96
Identities = 172/328 (52%), Positives = 228/328 (69%), Gaps = 5/328 (1%)
Query: 32 ESPGQNQK---EEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSD 88
E NQK K + T IL+ LL YD +LRP G T + DIYV S GPVS
Sbjct: 28 EDSSSNQKWVLAPKSQDTDVTLILNKLLREYDKKLRPDIGIKPTVIDVDIYVNSIGPVSS 87
Query: 89 VEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAP 148
+ MEY +D+FF QTW D RL+++ ++IL LN+ MV +W PDT FRN K + +H +T P
Sbjct: 88 INMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTP 147
Query: 149 NKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGP 208
N+L RI +G ILYT+RLTI+AEC ++L +FPMD H+CPL F SY YPK EMIY W K
Sbjct: 148 NQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYRWRKNS 207
Query: 209 EKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCI 268
++ + ++S L Q+D +G ++E + + G+Y+VMT+YF L R+MGYF IQTYIPCI
Sbjct: 208 VEAAD--QKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCI 265
Query: 269 MTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFA 328
+TV+LS VSFWI K++ PART GITTVLTMTTLS AR SLP+VSY TAMD F+ VCF
Sbjct: 266 LTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFL 325
Query: 329 FVFSALIEFAAVNYFTNIQMEKAKRKTS 356
FVF+AL+E+A +NY+++ + +KT+
Sbjct: 326 FVFAALMEYATLNYYSSCRKPTTTKKTT 353
Score = 38.5 bits (88), Expect = 0.016
Identities = 14/26 (53%), Positives = 20/26 (76%)
Query: 517 KIDKYARILFPVTFGAFNMVYWVVYL 542
++D Y+R+ FP +F FN+VYWV YL
Sbjct: 440 ELDSYSRVFFPTSFLLFNLVYWVGYL 465
>gi|189083762 gamma-aminobutyric acid A receptor, gamma 2 isoform 3
precursor [Homo sapiens]
Length = 515
Score = 346 bits (888), Expect = 3e-95
Identities = 181/387 (46%), Positives = 246/387 (63%), Gaps = 53/387 (13%)
Query: 49 TRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRL 108
T IL++LL+GYDN+LRP G T + TD+YV S GPV+ + MEYT+D+FF QTW D+RL
Sbjct: 67 TVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRL 126
Query: 109 KYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTI 168
K++ I++LRLN+ MV K+W PDTFFRN KK+ +H +T PN++ RI +G +LYT+RLTI
Sbjct: 127 KFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTI 186
Query: 169 SAECPMRLVDFPMDGHACPLKFGSYA---------------------------------- 194
AEC ++L +FPMD H+CPL+F S++
Sbjct: 187 DAECQLQLHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRV 246
Query: 195 ------YPKSEMIYTWTKGPEKSVEV-PKESSSLVQYDLIGQTVSSETIKSITGEYIVMT 247
YP+ E++Y W + SVEV S L Q+ +G ++E +K+ +G+Y+VM+
Sbjct: 247 AGISDGYPREEIVYQWKR---SSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMS 303
Query: 248 VYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISAR 307
VYF L R+MGYF IQTYIPC + V+LS VSFWINK++VPART GITTVLTMTTLS AR
Sbjct: 304 VYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIAR 363
Query: 308 HSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPV 367
SLPKVSY TAMD F++VCF FVFSAL+E+ ++YF + RK SK + P+
Sbjct: 364 KSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV------SNRKPSKDKDKKKKNPL 417
Query: 368 QRE---KHPEAPLQNTNANLNMRKRTN 391
R K P ++ +A + M T+
Sbjct: 418 LRMFSFKAPTIDIRPRSATIQMNNATH 444
Score = 42.0 bits (97), Expect = 0.001
Identities = 17/27 (62%), Positives = 20/27 (74%)
Query: 516 SKIDKYARILFPVTFGAFNMVYWVVYL 542
+K+D YARI FP F FN+VYWV YL
Sbjct: 487 AKMDSYARIFFPTAFCLFNLVYWVSYL 513
>gi|52426761 gamma-aminobutyric acid (GABA) A receptor, epsilon
precursor [Homo sapiens]
Length = 506
Score = 304 bits (778), Expect = 2e-82
Identities = 161/380 (42%), Positives = 234/380 (61%), Gaps = 20/380 (5%)
Query: 49 TRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRL 108
+RIL+++L YD++LRPG G T V +I V S GP+S ++MEYT+D+ F QTW D+RL
Sbjct: 72 SRILNTILSNYDHKLRPGIGEKPTVVTVEISVNSLGPLSILDMEYTIDIIFSQTWYDERL 131
Query: 109 KYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTI 168
Y+ E L LN +V+++W PDTFFRN K++ H +T PN++ RI ++G +LYT+R+TI
Sbjct: 132 CYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKVLYTIRMTI 191
Query: 169 SAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIG 228
A C + ++ FPMD H+CPL F S++YP++EMIY W + E K S L Q+D G
Sbjct: 192 DAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINE--KNSWKLFQFDFTG 249
Query: 229 QTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPAR 288
+ +E I + G+++VMT++F++ R+ GY Q Y+P +T +LS VSFWI ES PAR
Sbjct: 250 VSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPAR 309
Query: 289 TVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQM 348
T GIT+VLTMTTL +R + P+VSY TA+D++IA+CF F F AL+EFA +N+ Q
Sbjct: 310 TSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQ- 368
Query: 349 EKAKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGN--RTEV 406
+ A+P + +HP +A R R A H E+ V TE
Sbjct: 369 -----------TKAHASP--KLRHPRIN-SRAHARTRARSRACARQHQEAFVCQIVTTEG 414
Query: 407 GNHSSKSSTVVQE-SSKGTP 425
+ + S Q+ S G+P
Sbjct: 415 SDGEERPSCSAQQPPSPGSP 434
Score = 39.3 bits (90), Expect = 0.010
Identities = 14/27 (51%), Positives = 23/27 (85%)
Query: 517 KIDKYARILFPVTFGAFNMVYWVVYLS 543
++D Y+R++FPVTF FN++YW+V L+
Sbjct: 479 RLDNYSRVVFPVTFFFFNVLYWLVCLN 505
>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
precursor [Homo sapiens]
Length = 474
Score = 274 bits (700), Expect = 2e-73
Identities = 175/524 (33%), Positives = 264/524 (50%), Gaps = 69/524 (13%)
Query: 20 LLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIY 79
++ +C A NE + +E + D LL GYD RLRP FGGP +V I
Sbjct: 18 MITMVCCAHSTNEPSNMSYVKETV---------DRLLKGYDIRLRPDFGGPPVDVGMRID 68
Query: 80 VTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKK 139
V S VS+V M+YT+ ++F+Q+W DKRL Y G L L+N + ++W PDT+F N KK
Sbjct: 69 VASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKK 128
Query: 140 SVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSE 199
S H +T N++ R+ +GT+LY +R+T +A C M L +P+D C L+ SY Y +
Sbjct: 129 SFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDD 188
Query: 200 MIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYF 259
+ + W G V K L Q+ ++ + S+ ++ TG Y +++ F L+R +GYF
Sbjct: 189 IEFYWNGGEGAVTGVNK--IELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYF 246
Query: 260 MIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAM 319
++QTY+P + ILS VSFWIN ++ AR GITTVLTMTT+S R +LPK+ Y A+
Sbjct: 247 ILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAI 306
Query: 320 DWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAKRKTSKPPQEVPAAPVQREKHPEAPLQN 379
D ++ CF FVF AL+E+A VNY K PQ+ A+ + + + L+
Sbjct: 307 DIYLMGCFVFVFLALLEYAFVNYIF----------FGKGPQKKGASKQDQSANEKNKLEM 356
Query: 380 TNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQESS-KGTPRSYLASSPNPFSR 438
++ N L+ + E+ N +S S + S K T SY ++S
Sbjct: 357 NKVQVD--AHGNILL-------STLEIRNETSGSEVLTSVSDPKATMYSYDSAS------ 401
Query: 439 ANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGK 498
+ P S R Y G A RH S+ RI+ + +
Sbjct: 402 ------------IQYRKPLSSREAY-------GRALDRHGVPSK-GRIRRRASQL----- 436
Query: 499 LSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYL 542
P + + IDK++R+ FP+TF FN+VYW+ Y+
Sbjct: 437 -------KVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYV 473
>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 2 [Homo sapiens]
Length = 474
Score = 273 bits (697), Expect = 4e-73
Identities = 168/493 (34%), Positives = 257/493 (52%), Gaps = 59/493 (11%)
Query: 52 LDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD 111
+D LL GYD RLRP FGGP V +I + S VS+V M+YT+ ++F+Q W DKRL Y+
Sbjct: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
Query: 112 GPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAE 171
L L+N + ++W PDT+F N KKS H +T N++ R+ +GT+LY +R+T +A
Sbjct: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
Query: 172 CPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTV 231
C M L +P+D C L+ SY Y ++ + W +G + +V L Q+ ++ +
Sbjct: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW-RGDDNAV-TGVTKIELPQFSIVDYKL 217
Query: 232 SSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVF 291
++ + TG Y +++ F L+R +GYF++QTY+P I+ ILS VSFWIN ++ AR
Sbjct: 218 ITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVAL 277
Query: 292 GITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNY-FTNIQMEK 350
GITTVLTMTT++ R +LPK+ Y A+D ++ CF FVF AL+E+A VNY F ++
Sbjct: 278 GITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQR 337
Query: 351 AKRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHS 410
K+ K AA EK MR N + E+ + + E+ N
Sbjct: 338 QKKAAEK------AASANNEK--------------MRLDVNKMDPHENILLSTLEIKNEM 377
Query: 411 SKSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASV 470
+ S V+ G PRS + + AS R +PR +
Sbjct: 378 ATSEAVM---GLGDPRSTMLAY--------------------DASSIQYRKAGLPRHSFG 414
Query: 471 GSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTF 530
+A RHV + R++ + + T P + + ID+++RI FPV F
Sbjct: 415 RNALERHV-AQKKSRLRRRASQLKIT------------IPDLTDVNAIDRWSRIFFPVVF 461
Query: 531 GAFNMVYWVVYLS 543
FN+VYW+ Y++
Sbjct: 462 SFFNIVYWLYYVN 474
>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
isoform 1 [Homo sapiens]
Length = 512
Score = 270 bits (689), Expect = 3e-72
Identities = 169/511 (33%), Positives = 262/511 (51%), Gaps = 57/511 (11%)
Query: 52 LDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD 111
+D LL GYD RLRP FGGP V +I + S VS+V M+YT+ ++F+Q W DKRL Y+
Sbjct: 40 VDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYN 99
Query: 112 GPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAE 171
L L+N + ++W PDT+F N KKS H +T N++ R+ +GT+LY +R+T +A
Sbjct: 100 VIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 159
Query: 172 CPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTV 231
C M L +P+D C L+ SY Y ++ + W +G + +V L Q+ ++ +
Sbjct: 160 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW-RGDDNAV-TGVTKIELPQFSIVDYKL 217
Query: 232 SSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVF 291
++ + TG Y +++ F L+R +GYF++QTY+P I+ ILS VSFWIN ++ AR
Sbjct: 218 ITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVAL 277
Query: 292 GITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYF----TNIQ 347
GITTVLTMTT++ R +LPK+ Y A+D ++ CF FVF AL+E+A VNY +
Sbjct: 278 GITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQR 337
Query: 348 MEKAKRKTSKPPQEVPAAPVQREKHPEAPLQNT--------NANLNMRKRTNALVHS--- 396
+KA K + E V + + + T NL+ +RT S
Sbjct: 338 QKKAAEKAASANNEKMRLDVNKIFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYT 397
Query: 397 ----ESDVGNRTEVGNHSSKSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALP 452
E+ + + E+ N + S V+ G PRS + +
Sbjct: 398 MDPHENILLSTLEIKNEMATSEAVM---GLGDPRSTMLAY-------------------- 434
Query: 453 SASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATGKLSATPPPSAPPPSG 512
AS R +PR + +A RHV + R++ + + T P
Sbjct: 435 DASSIQYRKAGLPRHSFGRNALERHV-AQKKSRLRRRASQLKIT------------IPDL 481
Query: 513 SGTSKIDKYARILFPVTFGAFNMVYWVVYLS 543
+ + ID+++RI FPV F FN+VYW+ Y++
Sbjct: 482 TDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN 512
>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 2 precursor [Homo sapiens]
Length = 473
Score = 268 bits (684), Expect = 1e-71
Identities = 167/493 (33%), Positives = 256/493 (51%), Gaps = 61/493 (12%)
Query: 52 LDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD 111
+D LL GYD RLRP FGGP V +I + S VS+V M+YT+ ++F+Q W DKRL Y
Sbjct: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
Query: 112 GPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAE 171
G L L+N + ++W PDT+F N KKS H +T N++ R+ +GT+LY +R+T +A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
Query: 172 CPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTV 231
C M L +P+D C L+ SY Y ++ + W +G +K+V E L Q+ ++ +
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW-RGGDKAV-TGVERIELPQFSIVEHRL 218
Query: 232 SSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVF 291
S + TG Y +++ F L+R +GYF++QTY+P I+ ILS VSFWIN ++ AR
Sbjct: 219 VSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVAL 278
Query: 292 GITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKA 351
GITTVLTMTT++ R +LPK+ Y A+D ++ CF FVF AL+E+A VNY I +
Sbjct: 279 GITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNY---IFFGRG 335
Query: 352 KRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSS 411
++ K ++ A R K E+ + + N+ + T+ VH+E N G +
Sbjct: 336 PQRQKKLAEKTAKAKNDRSK-SESNRVDAHGNILL---TSLEVHNEM---NEVSGGIGDT 388
Query: 412 KSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVG 471
++S + ++S G RK S+
Sbjct: 389 RNSAISFDNS----------------------------------------GIQYRKQSMP 408
Query: 472 SASTRHVFGSR-LQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTF 530
G R L KT + + K+ P + + ID+++RI+FP TF
Sbjct: 409 REGHGRFLGDRSLPHKKTHLRRRSSQLKIKI--------PDLTDVNAIDRWSRIVFPFTF 460
Query: 531 GAFNMVYWVVYLS 543
FN+VYW+ Y++
Sbjct: 461 SLFNLVYWLYYVN 473
>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
isoform 1 precursor [Homo sapiens]
Length = 473
Score = 268 bits (684), Expect = 1e-71
Identities = 167/493 (33%), Positives = 256/493 (51%), Gaps = 61/493 (12%)
Query: 52 LDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYD 111
+D LL GYD RLRP FGGP V +I + S VS+V M+YT+ ++F+Q W DKRL Y
Sbjct: 41 VDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYS 100
Query: 112 GPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAE 171
G L L+N + ++W PDT+F N KKS H +T N++ R+ +GT+LY +R+T +A
Sbjct: 101 GIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAA 160
Query: 172 CPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTV 231
C M L +P+D C L+ SY Y ++ + W +G +K+V E L Q+ ++ +
Sbjct: 161 CMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYW-RGGDKAV-TGVERIELPQFSIVEHRL 218
Query: 232 SSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVF 291
S + TG Y +++ F L+R +GYF++QTY+P I+ ILS VSFWIN ++ AR
Sbjct: 219 VSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVAL 278
Query: 292 GITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKA 351
GITTVLTMTT++ R +LPK+ Y A+D ++ CF FVF AL+E+A VNY I +
Sbjct: 279 GITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNY---IFFGRG 335
Query: 352 KRKTSKPPQEVPAAPVQREKHPEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSS 411
++ K ++ A R K E+ + + N+ + T+ VH+E N G +
Sbjct: 336 PQRQKKLAEKTAKAKNDRSK-SESNRVDAHGNILL---TSLEVHNEM---NEVSGGIGDT 388
Query: 412 KSSTVVQESSKGTPRSYLASSPNPFSRANAAETISAARALPSASPTSIRTGYMPRKASVG 471
++S + ++S G RK S+
Sbjct: 389 RNSAISFDNS----------------------------------------GIQYRKQSMP 408
Query: 472 SASTRHVFGSR-LQRIKTTVNTIGATGKLSATPPPSAPPPSGSGTSKIDKYARILFPVTF 530
G R L KT + + K+ P + + ID+++RI+FP TF
Sbjct: 409 REGHGRFLGDRSLPHKKTHLRRRSSQLKIKI--------PDLTDVNAIDRWSRIVFPFTF 460
Query: 531 GAFNMVYWVVYLS 543
FN+VYW+ Y++
Sbjct: 461 SLFNLVYWLYYVN 473
>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
Length = 449
Score = 263 bits (671), Expect = 4e-70
Identities = 146/355 (41%), Positives = 207/355 (58%), Gaps = 7/355 (1%)
Query: 12 LSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPV 71
L +G F L V E+ + + +F L GYD R+RP F GP
Sbjct: 10 LVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPP 69
Query: 72 TEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKY-DGPIEILRLNNMMVTKVWTP 130
V +I++ SFG +++ M+Y +++F RQ W D RL Y + P + L L+ M+ +W P
Sbjct: 70 VNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKP 129
Query: 131 DTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKF 190
D FF N K + H +T NKL RI +NG +LY++RLT++ CPM L +FPMD C ++
Sbjct: 130 DLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQL 189
Query: 191 GSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSI-TGEYIVMTVY 249
S+ Y +++I+ W E V+V E +L Q+ L + K TG++ + V
Sbjct: 190 ESFGYTMNDLIFEWQD--EAPVQVA-EGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVR 246
Query: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309
FHL R+MGY++IQ YIP ++ VILS VSFWIN ++ PAR GITTVLTMTT S +R S
Sbjct: 247 FHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRAS 306
Query: 310 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQME--KAKRKTSKPPQEV 362
LPKVSY A+D ++AVC FVFSAL+E+AAVN+ + E + +RK EV
Sbjct: 307 LPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKDDEV 361
Score = 33.9 bits (76), Expect = 0.40
Identities = 13/25 (52%), Positives = 17/25 (68%)
Query: 517 KIDKYARILFPVTFGAFNMVYWVVY 541
KID +R FP+ F FN+ YWV+Y
Sbjct: 412 KIDTISRACFPLAFLIFNIFYWVIY 436
>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 261 bits (668), Expect = 9e-70
Identities = 142/336 (42%), Positives = 207/336 (61%), Gaps = 9/336 (2%)
Query: 31 NESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVE 90
++S Q + L +F L GYD R+RP F GP V +I++ SFG V++
Sbjct: 30 HDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETT 89
Query: 91 MEYTMDVFFRQTWIDKRLKY-DGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPN 149
M+Y +++F RQ W D RL Y + P + L L+ M+ +W PD FF N K + H++T N
Sbjct: 90 MDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDN 149
Query: 150 KLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTW-TKGP 208
KL RI +NG +LY++RLT++ CPM L +FPMD C ++ S+ Y +++I+ W + GP
Sbjct: 150 KLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGP 209
Query: 209 EKSVEVPKESSSLVQYDLIGQTVSSETIKSI-TGEYIVMTVYFHLRRKMGYFMIQTYIPC 267
V+V E +L Q+ L + K TG++ + V FHL R+MGY++IQ YIP
Sbjct: 210 ---VQVA-EGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPS 265
Query: 268 IMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCF 327
++ VILS VSFWIN ++ PAR GITTVLTMTT S +R SLPKVSY A+D ++AVC
Sbjct: 266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 325
Query: 328 AFVFSALIEFAAVNYFTNIQME--KAKRKTSKPPQE 361
FVF+AL+E+AAVN+ + E + +R+ + +E
Sbjct: 326 LFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKE 361
Score = 34.7 bits (78), Expect = 0.23
Identities = 18/56 (32%), Positives = 23/56 (41%), Gaps = 8/56 (14%)
Query: 494 GATGKLSATPPPSAPPPSGSGTSK--------IDKYARILFPVTFGAFNMVYWVVY 541
G K + P PP G K ID +R FP+ F FN+ YW+ Y
Sbjct: 386 GTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441
>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
Length = 452
Score = 261 bits (668), Expect = 9e-70
Identities = 142/336 (42%), Positives = 207/336 (61%), Gaps = 9/336 (2%)
Query: 31 NESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVE 90
++S Q + L +F L GYD R+RP F GP V +I++ SFG V++
Sbjct: 30 HDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETT 89
Query: 91 MEYTMDVFFRQTWIDKRLKY-DGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPN 149
M+Y +++F RQ W D RL Y + P + L L+ M+ +W PD FF N K + H++T N
Sbjct: 90 MDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDN 149
Query: 150 KLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTW-TKGP 208
KL RI +NG +LY++RLT++ CPM L +FPMD C ++ S+ Y +++I+ W + GP
Sbjct: 150 KLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGP 209
Query: 209 EKSVEVPKESSSLVQYDLIGQTVSSETIKSI-TGEYIVMTVYFHLRRKMGYFMIQTYIPC 267
V+V E +L Q+ L + K TG++ + V FHL R+MGY++IQ YIP
Sbjct: 210 ---VQVA-EGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPS 265
Query: 268 IMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCF 327
++ VILS VSFWIN ++ PAR GITTVLTMTT S +R SLPKVSY A+D ++AVC
Sbjct: 266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 325
Query: 328 AFVFSALIEFAAVNYFTNIQME--KAKRKTSKPPQE 361
FVF+AL+E+AAVN+ + E + +R+ + +E
Sbjct: 326 LFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKE 361
Score = 34.7 bits (78), Expect = 0.23
Identities = 18/56 (32%), Positives = 23/56 (41%), Gaps = 8/56 (14%)
Query: 494 GATGKLSATPPPSAPPPSGSGTSK--------IDKYARILFPVTFGAFNMVYWVVY 541
G K + P PP G K ID +R FP+ F FN+ YW+ Y
Sbjct: 386 GTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441
>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
Length = 464
Score = 261 bits (668), Expect = 9e-70
Identities = 146/352 (41%), Positives = 205/352 (58%), Gaps = 11/352 (3%)
Query: 12 LSAGVSFALLRFLCLAVCLNESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPV 71
L +G F L V E+ + + +F L GYD R+RP F GP
Sbjct: 10 LVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPP 69
Query: 72 TEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKY-DGPIEILRLNNMMVTKVWTP 130
V +I++ SFG +++ M+Y +++F RQ W D RL Y + P + L L+ M+ +W P
Sbjct: 70 VNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKP 129
Query: 131 DTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKF 190
D FF N K + H +T NKL RI +NG +LY++RLT++ CPM L +FPMD C ++
Sbjct: 130 DLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQL 189
Query: 191 GSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSI-TGEYIVMTVY 249
S+ Y +++I+ W E V+V E +L Q+ L + K TG++ + V
Sbjct: 190 ESFGYTMNDLIFEWQD--EAPVQVA-EGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVR 246
Query: 250 FHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHS 309
FHL R+MGY++IQ YIP ++ VILS VSFWIN ++ PAR GITTVLTMTT S +R S
Sbjct: 247 FHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRAS 306
Query: 310 LPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQME------KAKRKT 355
LPKVSY A+D ++AVC FVFSAL+E+AAVN+ + E K K KT
Sbjct: 307 LPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKT 358
Score = 33.9 bits (76), Expect = 0.40
Identities = 13/25 (52%), Positives = 17/25 (68%)
Query: 517 KIDKYARILFPVTFGAFNMVYWVVY 541
KID +R FP+ F FN+ YWV+Y
Sbjct: 427 KIDTISRACFPLAFLIFNIFYWVIY 451
>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
Length = 452
Score = 261 bits (667), Expect = 1e-69
Identities = 141/336 (41%), Positives = 207/336 (61%), Gaps = 9/336 (2%)
Query: 31 NESPGQNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVE 90
++S Q + L +F L GYD R+RP F GP V +I++ SFG +++
Sbjct: 30 HDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETT 89
Query: 91 MEYTMDVFFRQTWIDKRLKY-DGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPN 149
M+Y +++F RQ W D RL Y + P + L L+ M+ +W PD FF N K + H++T N
Sbjct: 90 MDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDN 149
Query: 150 KLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTW-TKGP 208
KL RI +NG +LY++RLT++ CPM L +FPMD C ++ S+ Y +++I+ W + GP
Sbjct: 150 KLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGP 209
Query: 209 EKSVEVPKESSSLVQYDLIGQTVSSETIKSI-TGEYIVMTVYFHLRRKMGYFMIQTYIPC 267
V+V E +L Q+ L + K TG++ + V FHL R+MGY++IQ YIP
Sbjct: 210 ---VQVA-EGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPS 265
Query: 268 IMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCF 327
++ VILS VSFWIN ++ PAR GITTVLTMTT S +R SLPKVSY A+D ++AVC
Sbjct: 266 LLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 325
Query: 328 AFVFSALIEFAAVNYFTNIQME--KAKRKTSKPPQE 361
FVF+AL+E+AAVN+ + E + +R+ + +E
Sbjct: 326 LFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKE 361
Score = 34.7 bits (78), Expect = 0.23
Identities = 18/56 (32%), Positives = 23/56 (41%), Gaps = 8/56 (14%)
Query: 494 GATGKLSATPPPSAPPPSGSGTSK--------IDKYARILFPVTFGAFNMVYWVVY 541
G K + P PP G K ID +R FP+ F FN+ YW+ Y
Sbjct: 386 GTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITY 441
>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
sapiens]
Length = 457
Score = 256 bits (654), Expect = 4e-68
Identities = 137/317 (43%), Positives = 199/317 (62%), Gaps = 12/317 (3%)
Query: 52 LDSLL---DGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRL 108
LD L+ GYD R+RP F GP V +I++ SFG +++ M+Y +++F RQ W D RL
Sbjct: 42 LDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRL 101
Query: 109 KY-DGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLT 167
Y + P + L L+ M+ +W PD FF N K + H +T NKL RI RNG +LY++R+T
Sbjct: 102 AYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRIT 161
Query: 168 ISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLI 227
++ CPM L +FPMD C ++ S+ Y +++I+ W + + +V+V + +L Q+ L
Sbjct: 162 LTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQE--QGAVQV-ADGLTLPQFILK 218
Query: 228 GQTVSSETIKSI-TGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVP 286
+ K TG++ + FHL R+MGY++IQ YIP ++ VILS +SFWIN ++ P
Sbjct: 219 EEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAP 278
Query: 287 ARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNI 346
AR GITTVLTMTT S +R SLPKVSY A+D ++AVC FVFSAL+E+AAVN+ +
Sbjct: 279 ARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQ 338
Query: 347 QME----KAKRKTSKPP 359
E + KR+ K P
Sbjct: 339 HKELLRFRRKRRHHKSP 355
Score = 42.4 bits (98), Expect = 0.001
Identities = 25/70 (35%), Positives = 33/70 (47%), Gaps = 9/70 (12%)
Query: 480 GSRLQRIKTTVNTIGATGKLSATPPPSAPPPSGSG--------TSKIDKYARILFPVTFG 531
G + K ++ GA + PPP AP S KIDK +RI FP+ F
Sbjct: 378 GPACLQAKDGISVKGANNSNTTNPPP-APSKSPEEMRKLFIQRAKKIDKISRIGFPMAFL 436
Query: 532 AFNMVYWVVY 541
FNM YW++Y
Sbjct: 437 IFNMFYWIIY 446
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.131 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,498,007
Number of Sequences: 37866
Number of extensions: 899768
Number of successful extensions: 5542
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 5235
Number of HSP's gapped (non-prelim): 386
length of query: 554
length of database: 18,247,518
effective HSP length: 107
effective length of query: 447
effective length of database: 14,195,856
effective search space: 6345547632
effective search space used: 6345547632
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.