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Search of human proteins with 34304360
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34304360 nephrocystin 3 [Homo sapiens]
(1330 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34304360 nephrocystin 3 [Homo sapiens] 2655 0.0
gi|41871960 kinesin-like 8 isoform b [Homo sapiens] 147 9e-35
gi|41871955 kinesin-like 8 isoform a [Homo sapiens] 147 9e-35
gi|41871946 kinesin-like 8 isoform a [Homo sapiens] 147 9e-35
gi|198041734 kinesin light chain 2 isoform 1 [Homo sapiens] 146 1e-34
gi|198041731 kinesin light chain 2 isoform 1 [Homo sapiens] 146 1e-34
gi|198041728 kinesin light chain 2 isoform 2 [Homo sapiens] 146 1e-34
gi|12383062 kinesin light chain 2 isoform 1 [Homo sapiens] 146 1e-34
gi|194306559 kinesin light chain 1 isoform 3 [Homo sapiens] 146 1e-34
gi|110735431 kinesin light chain 1 isoform 2 [Homo sapiens] 146 1e-34
gi|33620730 kinesin light chain 1 isoform 1 [Homo sapiens] 146 1e-34
gi|91825557 kinesin light chain 3 [Homo sapiens] 136 2e-31
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 86 3e-16
gi|87162455 hypothetical protein LOC23277 [Homo sapiens] 70 2e-11
gi|18104962 amyloid beta precursor protein-binding protein 2 [Ho... 69 2e-11
gi|83415184 transmembrane and tetratricopeptide repeat containin... 67 9e-11
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 67 1e-10
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 67 1e-10
gi|19923891 kinesin-like 8 isoform c [Homo sapiens] 67 1e-10
gi|24308163 fem-1 homolog a [Homo sapiens] 56 2e-07
gi|17864094 feminization 1 homolog a [Homo sapiens] 54 1e-06
gi|22547159 tetratricopeptide repeat domain 19 [Homo sapiens] 52 3e-06
gi|118766328 transmembrane and tetratricopeptide repeat containi... 48 5e-05
gi|118766330 transmembrane and tetratricopeptide repeat containi... 48 5e-05
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 47 1e-04
gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens] 45 4e-04
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 45 5e-04
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 44 8e-04
gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo... 44 8e-04
gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo... 44 8e-04
>gi|34304360 nephrocystin 3 [Homo sapiens]
Length = 1330
Score = 2655 bits (6881), Expect = 0.0
Identities = 1330/1330 (100%), Positives = 1330/1330 (100%)
Query: 1 MGTASSLVSPAGGEVIEDTYGAGGGEACEIPVEVKPKARLLRNSFRRGAGAAAGAGPGSL 60
MGTASSLVSPAGGEVIEDTYGAGGGEACEIPVEVKPKARLLRNSFRRGAGAAAGAGPGSL
Sbjct: 1 MGTASSLVSPAGGEVIEDTYGAGGGEACEIPVEVKPKARLLRNSFRRGAGAAAGAGPGSL 60
Query: 61 PRGVGAGGLLGASFKSTGSSVPELEYAAAEYERLRKEYEIFRVSKNQELLSMGRREAKLD 120
PRGVGAGGLLGASFKSTGSSVPELEYAAAEYERLRKEYEIFRVSKNQELLSMGRREAKLD
Sbjct: 61 PRGVGAGGLLGASFKSTGSSVPELEYAAAEYERLRKEYEIFRVSKNQELLSMGRREAKLD 120
Query: 121 TENKRLRAELQALQKTYQKILREKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKE 180
TENKRLRAELQALQKTYQKILREKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKE
Sbjct: 121 TENKRLRAELQALQKTYQKILREKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKE 180
Query: 181 NEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDVTAAGTQCEYWTGGALGSE 240
NEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDVTAAGTQCEYWTGGALGSE
Sbjct: 181 NEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDVTAAGTQCEYWTGGALGSE 240
Query: 241 PSIGSMIQLQQSFRGPEFAHSSIDVEGPFANVNRDDWDIAVASLLQVTPLFSHSLWSNTV 300
PSIGSMIQLQQSFRGPEFAHSSIDVEGPFANVNRDDWDIAVASLLQVTPLFSHSLWSNTV
Sbjct: 241 PSIGSMIQLQQSFRGPEFAHSSIDVEGPFANVNRDDWDIAVASLLQVTPLFSHSLWSNTV 300
Query: 301 RCYLIYTDETQPEMDLFLKDYSPKLKRMCETMGYFFHAVYFPIDVENQYLTVRKWEIEKS 360
RCYLIYTDETQPEMDLFLKDYSPKLKRMCETMGYFFHAVYFPIDVENQYLTVRKWEIEKS
Sbjct: 301 RCYLIYTDETQPEMDLFLKDYSPKLKRMCETMGYFFHAVYFPIDVENQYLTVRKWEIEKS 360
Query: 361 SLVILFIHLTLPSLLLEDCEEAFLKNPEGKPRLIFHRLEDGKVSSDSVQQLIDQVSNLNK 420
SLVILFIHLTLPSLLLEDCEEAFLKNPEGKPRLIFHRLEDGKVSSDSVQQLIDQVSNLNK
Sbjct: 361 SLVILFIHLTLPSLLLEDCEEAFLKNPEGKPRLIFHRLEDGKVSSDSVQQLIDQVSNLNK 420
Query: 421 TSKAKIIDHSGDPAEGVYKTYICVEKIIKQDILGFENTDLETKDLGSEDSIPEEDDFGDV 480
TSKAKIIDHSGDPAEGVYKTYICVEKIIKQDILGFENTDLETKDLGSEDSIPEEDDFGDV
Sbjct: 421 TSKAKIIDHSGDPAEGVYKTYICVEKIIKQDILGFENTDLETKDLGSEDSIPEEDDFGDV 480
Query: 481 LWDIHDEQEQMETFQQASNSAHELGFEKYYQRLNDLVAAPAPIPPLLVSGGPGSGKSLLL 540
LWDIHDEQEQMETFQQASNSAHELGFEKYYQRLNDLVAAPAPIPPLLVSGGPGSGKSLLL
Sbjct: 481 LWDIHDEQEQMETFQQASNSAHELGFEKYYQRLNDLVAAPAPIPPLLVSGGPGSGKSLLL 540
Query: 541 SKWIQLQQKNSPNTLILSHFVGRPMSTSSESSLIIKRLTLKLMQHSWSVSALTLDPAKLL 600
SKWIQLQQKNSPNTLILSHFVGRPMSTSSESSLIIKRLTLKLMQHSWSVSALTLDPAKLL
Sbjct: 541 SKWIQLQQKNSPNTLILSHFVGRPMSTSSESSLIIKRLTLKLMQHSWSVSALTLDPAKLL 600
Query: 601 EEFPRWLEKLSARHQGSIIIVIDSIDQVQQVEKHMKWLIDPLPVNVRVIVSVNVETCPPA 660
EEFPRWLEKLSARHQGSIIIVIDSIDQVQQVEKHMKWLIDPLPVNVRVIVSVNVETCPPA
Sbjct: 601 EEFPRWLEKLSARHQGSIIIVIDSIDQVQQVEKHMKWLIDPLPVNVRVIVSVNVETCPPA 660
Query: 661 WRLWPTLHLDPLSPKDAKSIIIAECHSVDIKLSKEQEKKLERHCRSATTCNALYVTLFGK 720
WRLWPTLHLDPLSPKDAKSIIIAECHSVDIKLSKEQEKKLERHCRSATTCNALYVTLFGK
Sbjct: 661 WRLWPTLHLDPLSPKDAKSIIIAECHSVDIKLSKEQEKKLERHCRSATTCNALYVTLFGK 720
Query: 721 MIARAGRAGNLDKILHQCFQCQDTLSLYRLVLHSIRESMANDVDKELMKQILCLVNVSHN 780
MIARAGRAGNLDKILHQCFQCQDTLSLYRLVLHSIRESMANDVDKELMKQILCLVNVSHN
Sbjct: 721 MIARAGRAGNLDKILHQCFQCQDTLSLYRLVLHSIRESMANDVDKELMKQILCLVNVSHN 780
Query: 781 GVSESELMELYPEMSWTFLTSLIHSLYKMCLLTYGCGLLRFQHLQAWETVRLEYLEGPTV 840
GVSESELMELYPEMSWTFLTSLIHSLYKMCLLTYGCGLLRFQHLQAWETVRLEYLEGPTV
Sbjct: 781 GVSESELMELYPEMSWTFLTSLIHSLYKMCLLTYGCGLLRFQHLQAWETVRLEYLEGPTV 840
Query: 841 TSSYRQKLINYFTLQLSQDRVTWRSADELPWLFQQQGSKQKLHDCLLNLFVSQNLYKRGH 900
TSSYRQKLINYFTLQLSQDRVTWRSADELPWLFQQQGSKQKLHDCLLNLFVSQNLYKRGH
Sbjct: 841 TSSYRQKLINYFTLQLSQDRVTWRSADELPWLFQQQGSKQKLHDCLLNLFVSQNLYKRGH 900
Query: 901 FAELLSYWQFVGKDKSAMATEYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLS 960
FAELLSYWQFVGKDKSAMATEYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLS
Sbjct: 901 FAELLSYWQFVGKDKSAMATEYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLS 960
Query: 961 QAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYG 1020
QAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYG
Sbjct: 961 QAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYG 1020
Query: 1021 ADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQL 1080
ADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQL
Sbjct: 1021 ADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQL 1080
Query: 1081 EELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNN 1140
EELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNN
Sbjct: 1081 EELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNN 1140
Query: 1141 LAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY 1200
LAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY
Sbjct: 1141 LAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY 1200
Query: 1201 ELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRV 1260
ELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRV
Sbjct: 1201 ELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRV 1260
Query: 1261 GETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAPSRHSSSGDTFSLKTAHS 1320
GETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAPSRHSSSGDTFSLKTAHS
Sbjct: 1261 GETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAPSRHSSSGDTFSLKTAHS 1320
Query: 1321 PNVFLQQGQR 1330
PNVFLQQGQR
Sbjct: 1321 PNVFLQQGQR 1330
>gi|41871960 kinesin-like 8 isoform b [Homo sapiens]
Length = 637
Score = 147 bits (370), Expect = 9e-35
Identities = 116/352 (32%), Positives = 156/352 (44%), Gaps = 48/352 (13%)
Query: 982 PRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQN 1041
P ++LH L Y ++ A L KQALE E G HP A L LA +Y+ QN
Sbjct: 226 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQN 285
Query: 1042 KYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGV 1101
KY++A H L AL + E TLG D P A TLN L V
Sbjct: 286 KYKEAAH------------------------LLNDALSIRESTLGPDHPAVAATLNNLAV 321
Query: 1102 LYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERA 1161
LY + + A+ +R+LE+RE+VLG +HPD A+ LNNLA LC + +Y+ E Y+RA
Sbjct: 322 LYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRA 381
Query: 1162 LDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY-ELAVEIRQKSFGPKHPSVAT 1220
L I L PD+P++A T +LA Y K GK +A LY E+ + FG
Sbjct: 382 LAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKP 441
Query: 1221 ALVNLAVL--YSQMKKHVEALPLYE-----RALKIYEDSLGRMHPRVGETLKNLAVLSYE 1273
++ S+ + H P E +A K+ P V TL+NL L
Sbjct: 442 IWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKV-------SSPTVNTTLRNLGALYRR 494
Query: 1274 GGDFEKAAELYKRAMEIKEAET---------SLLGGKAPSRHSSSGDTFSLK 1316
G E A L + A+ + T LLG R S G S+K
Sbjct: 495 QGKLEAAETLEECALRSRRQGTDPISQTKVAELLGESDGRRTSQEGPGDSVK 546
Score = 146 bits (368), Expect = 1e-34
Identities = 84/203 (41%), Positives = 111/203 (54%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE ER G HPD A LN LA +
Sbjct: 222 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 281
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y +A L AL IR L PDHP++A T+ +LA+LY K GK +A PL + A+E
Sbjct: 282 RDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALE 341
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K+ Y+RAL IYE LG +P V T
Sbjct: 342 IREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKN 401
Query: 1266 NLAVLSYEGGDFEKAAELYKRAM 1288
NLA + G + +A LYK +
Sbjct: 402 NLASCYLKQGKYAEAETLYKEIL 424
Score = 122 bits (306), Expect = 2e-27
Identities = 79/227 (34%), Positives = 113/227 (49%), Gaps = 24/227 (10%)
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G + P R L L Y Q +YE A L ++AL+
Sbjct: 222 GYEIPARLRTLHNLVIQYAAQGRYEVA------------------------VPLCKQALE 257
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
E T G+ PD A LN L ++Y QN + A L +L +RE LGPDHP A +LN
Sbjct: 258 DLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLN 317
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPL 1199
NLA L ++ +Y +AE L +RAL+IR + L +HP +A + +LA+L + GK +
Sbjct: 318 NLAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERY 377
Query: 1200 YELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL 1246
Y+ A+ I + GP +P+VA NLA Y + K+ EA LY+ L
Sbjct: 378 YQRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 424
Score = 112 bits (281), Expect = 2e-24
Identities = 87/297 (29%), Positives = 131/297 (44%), Gaps = 68/297 (22%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E HP VA L+ LA VY K+ A L AL I E+
Sbjct: 246 EVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTL 305
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G DHP A L LA LY K+ KY++AE L +RAL+
Sbjct: 306 GPDHPAVAATLNNLAVLYGKRGKYKEAEP------------------------LCQRALE 341
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+ E LG + PD A+ LN L +L Q E +++ +R+L + E LGPD+P+ A++ N
Sbjct: 342 IREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKN 401
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRR--------------------------------- 1166
NLA+ ++ +Y +AE LY+ L
Sbjct: 402 NLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREEMSKSRHHEGG 461
Query: 1167 ----------RALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGP 1213
+A P++ T+++L LY++ GKL+ A L E A+ R++ P
Sbjct: 462 TPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKLEAAETLEECALRSRRQGTDP 518
Score = 108 bits (269), Expect = 4e-23
Identities = 63/167 (37%), Positives = 93/167 (55%)
Query: 1128 GPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILY 1187
G + P ++L+NL + +Y+ A L ++AL+ R HP +A + LA++Y
Sbjct: 222 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 281
Query: 1188 KKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALK 1247
+ K +A L A+ IR+ + GP HP+VA L NLAVLY + K+ EA PL +RAL+
Sbjct: 282 RDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALE 341
Query: 1248 IYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAE 1294
I E LG HP V + L NLA+L G +E Y+RA+ I E +
Sbjct: 342 IREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQ 388
>gi|41871955 kinesin-like 8 isoform a [Homo sapiens]
Length = 619
Score = 147 bits (370), Expect = 9e-35
Identities = 116/352 (32%), Positives = 156/352 (44%), Gaps = 48/352 (13%)
Query: 982 PRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQN 1041
P ++LH L Y ++ A L KQALE E G HP A L LA +Y+ QN
Sbjct: 208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQN 267
Query: 1042 KYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGV 1101
KY++A H L AL + E TLG D P A TLN L V
Sbjct: 268 KYKEAAH------------------------LLNDALSIRESTLGPDHPAVAATLNNLAV 303
Query: 1102 LYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERA 1161
LY + + A+ +R+LE+RE+VLG +HPD A+ LNNLA LC + +Y+ E Y+RA
Sbjct: 304 LYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRA 363
Query: 1162 LDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY-ELAVEIRQKSFGPKHPSVAT 1220
L I L PD+P++A T +LA Y K GK +A LY E+ + FG
Sbjct: 364 LAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKP 423
Query: 1221 ALVNLAVL--YSQMKKHVEALPLYE-----RALKIYEDSLGRMHPRVGETLKNLAVLSYE 1273
++ S+ + H P E +A K+ P V TL+NL L
Sbjct: 424 IWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKV-------SSPTVNTTLRNLGALYRR 476
Query: 1274 GGDFEKAAELYKRAMEIKEAET---------SLLGGKAPSRHSSSGDTFSLK 1316
G E A L + A+ + T LLG R S G S+K
Sbjct: 477 QGKLEAAETLEECALRSRRQGTDPISQTKVAELLGESDGRRTSQEGPGDSVK 528
Score = 146 bits (368), Expect = 1e-34
Identities = 84/203 (41%), Positives = 111/203 (54%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE ER G HPD A LN LA +
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 263
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y +A L AL IR L PDHP++A T+ +LA+LY K GK +A PL + A+E
Sbjct: 264 RDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALE 323
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K+ Y+RAL IYE LG +P V T
Sbjct: 324 IREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKN 383
Query: 1266 NLAVLSYEGGDFEKAAELYKRAM 1288
NLA + G + +A LYK +
Sbjct: 384 NLASCYLKQGKYAEAETLYKEIL 406
Score = 122 bits (306), Expect = 2e-27
Identities = 79/227 (34%), Positives = 113/227 (49%), Gaps = 24/227 (10%)
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G + P R L L Y Q +YE A L ++AL+
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVA------------------------VPLCKQALE 239
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
E T G+ PD A LN L ++Y QN + A L +L +RE LGPDHP A +LN
Sbjct: 240 DLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLN 299
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPL 1199
NLA L ++ +Y +AE L +RAL+IR + L +HP +A + +LA+L + GK +
Sbjct: 300 NLAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERY 359
Query: 1200 YELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL 1246
Y+ A+ I + GP +P+VA NLA Y + K+ EA LY+ L
Sbjct: 360 YQRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 406
Score = 112 bits (281), Expect = 2e-24
Identities = 87/297 (29%), Positives = 131/297 (44%), Gaps = 68/297 (22%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E HP VA L+ LA VY K+ A L AL I E+
Sbjct: 228 EVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTL 287
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G DHP A L LA LY K+ KY++AE L +RAL+
Sbjct: 288 GPDHPAVAATLNNLAVLYGKRGKYKEAEP------------------------LCQRALE 323
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+ E LG + PD A+ LN L +L Q E +++ +R+L + E LGPD+P+ A++ N
Sbjct: 324 IREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKN 383
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRR--------------------------------- 1166
NLA+ ++ +Y +AE LY+ L
Sbjct: 384 NLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREEMSKSRHHEGG 443
Query: 1167 ----------RALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGP 1213
+A P++ T+++L LY++ GKL+ A L E A+ R++ P
Sbjct: 444 TPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKLEAAETLEECALRSRRQGTDP 500
Score = 108 bits (269), Expect = 4e-23
Identities = 63/167 (37%), Positives = 93/167 (55%)
Query: 1128 GPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILY 1187
G + P ++L+NL + +Y+ A L ++AL+ R HP +A + LA++Y
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 263
Query: 1188 KKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALK 1247
+ K +A L A+ IR+ + GP HP+VA L NLAVLY + K+ EA PL +RAL+
Sbjct: 264 RDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALE 323
Query: 1248 IYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAE 1294
I E LG HP V + L NLA+L G +E Y+RA+ I E +
Sbjct: 324 IREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQ 370
>gi|41871946 kinesin-like 8 isoform a [Homo sapiens]
Length = 619
Score = 147 bits (370), Expect = 9e-35
Identities = 116/352 (32%), Positives = 156/352 (44%), Gaps = 48/352 (13%)
Query: 982 PRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQN 1041
P ++LH L Y ++ A L KQALE E G HP A L LA +Y+ QN
Sbjct: 208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQN 267
Query: 1042 KYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGV 1101
KY++A H L AL + E TLG D P A TLN L V
Sbjct: 268 KYKEAAH------------------------LLNDALSIRESTLGPDHPAVAATLNNLAV 303
Query: 1102 LYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERA 1161
LY + + A+ +R+LE+RE+VLG +HPD A+ LNNLA LC + +Y+ E Y+RA
Sbjct: 304 LYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRA 363
Query: 1162 LDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY-ELAVEIRQKSFGPKHPSVAT 1220
L I L PD+P++A T +LA Y K GK +A LY E+ + FG
Sbjct: 364 LAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKP 423
Query: 1221 ALVNLAVL--YSQMKKHVEALPLYE-----RALKIYEDSLGRMHPRVGETLKNLAVLSYE 1273
++ S+ + H P E +A K+ P V TL+NL L
Sbjct: 424 IWMHAEEREEMSKSRHHEGGTPYAEYGGWYKACKV-------SSPTVNTTLRNLGALYRR 476
Query: 1274 GGDFEKAAELYKRAMEIKEAET---------SLLGGKAPSRHSSSGDTFSLK 1316
G E A L + A+ + T LLG R S G S+K
Sbjct: 477 QGKLEAAETLEECALRSRRQGTDPISQTKVAELLGESDGRRTSQEGPGDSVK 528
Score = 146 bits (368), Expect = 1e-34
Identities = 84/203 (41%), Positives = 111/203 (54%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE ER G HPD A LN LA +
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 263
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y +A L AL IR L PDHP++A T+ +LA+LY K GK +A PL + A+E
Sbjct: 264 RDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALE 323
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K+ Y+RAL IYE LG +P V T
Sbjct: 324 IREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKN 383
Query: 1266 NLAVLSYEGGDFEKAAELYKRAM 1288
NLA + G + +A LYK +
Sbjct: 384 NLASCYLKQGKYAEAETLYKEIL 406
Score = 122 bits (306), Expect = 2e-27
Identities = 79/227 (34%), Positives = 113/227 (49%), Gaps = 24/227 (10%)
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G + P R L L Y Q +YE A L ++AL+
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVA------------------------VPLCKQALE 239
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
E T G+ PD A LN L ++Y QN + A L +L +RE LGPDHP A +LN
Sbjct: 240 DLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLN 299
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPL 1199
NLA L ++ +Y +AE L +RAL+IR + L +HP +A + +LA+L + GK +
Sbjct: 300 NLAVLYGKRGKYKEAEPLCQRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERY 359
Query: 1200 YELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL 1246
Y+ A+ I + GP +P+VA NLA Y + K+ EA LY+ L
Sbjct: 360 YQRALAIYEGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 406
Score = 112 bits (281), Expect = 2e-24
Identities = 87/297 (29%), Positives = 131/297 (44%), Gaps = 68/297 (22%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E HP VA L+ LA VY K+ A L AL I E+
Sbjct: 228 EVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTL 287
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G DHP A L LA LY K+ KY++AE L +RAL+
Sbjct: 288 GPDHPAVAATLNNLAVLYGKRGKYKEAEP------------------------LCQRALE 323
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+ E LG + PD A+ LN L +L Q E +++ +R+L + E LGPD+P+ A++ N
Sbjct: 324 IREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNVARTKN 383
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRR--------------------------------- 1166
NLA+ ++ +Y +AE LY+ L
Sbjct: 384 NLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREEMSKSRHHEGG 443
Query: 1167 ----------RALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGP 1213
+A P++ T+++L LY++ GKL+ A L E A+ R++ P
Sbjct: 444 TPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKLEAAETLEECALRSRRQGTDP 500
Score = 108 bits (269), Expect = 4e-23
Identities = 63/167 (37%), Positives = 93/167 (55%)
Query: 1128 GPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILY 1187
G + P ++L+NL + +Y+ A L ++AL+ R HP +A + LA++Y
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 263
Query: 1188 KKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALK 1247
+ K +A L A+ IR+ + GP HP+VA L NLAVLY + K+ EA PL +RAL+
Sbjct: 264 RDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALE 323
Query: 1248 IYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAE 1294
I E LG HP V + L NLA+L G +E Y+RA+ I E +
Sbjct: 324 IREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQ 370
>gi|198041734 kinesin light chain 2 isoform 1 [Homo sapiens]
Length = 622
Score = 146 bits (369), Expect = 1e-34
Identities = 108/308 (35%), Positives = 144/308 (46%), Gaps = 37/308 (12%)
Query: 982 PRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQN 1041
P ++LH L Y ++ A L KQALE E G DHP A L LA +Y+ QN
Sbjct: 195 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 254
Query: 1042 KYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGV 1101
KY++A H L AL + E TLGKD P A TLN L V
Sbjct: 255 KYKEAAH------------------------LLNDALAIREKTLGKDHPAVAATLNNLAV 290
Query: 1102 LYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERA 1161
LY + + A+ KR+LE+RE+VLG HPD A+ L+NLA LC + + ++ E Y RA
Sbjct: 291 LYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRA 350
Query: 1162 LDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY-ELAVEIRQKSFGPKHPSVAT 1220
L+I L PD P++A T +LA Y K GK A LY E+ +K FG +
Sbjct: 351 LEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKP 410
Query: 1221 ALVNLAVLYSQMKKHVEALPLYE-----RALKIYEDSLGRMHPRVGETLKNLAVLSYEGG 1275
++ K ++ P E +A K+ DS P V TL++L L G
Sbjct: 411 IWMHAEEREESKDKRRDSAPYGEYGSWYKACKV--DS-----PTVNTTLRSLGALYRRQG 463
Query: 1276 DFEKAAEL 1283
E A L
Sbjct: 464 KLEAAHTL 471
Score = 141 bits (355), Expect = 5e-33
Identities = 83/203 (40%), Positives = 111/203 (54%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE E+ G DHPD A LN LA +
Sbjct: 191 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 250
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y +A L AL IR + L DHP++A T+ +LA+LY K GK +A PL + A+E
Sbjct: 251 RDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE 310
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K E Y RAL+IY LG P V +T
Sbjct: 311 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKN 370
Query: 1266 NLAVLSYEGGDFEKAAELYKRAM 1288
NLA + G ++ A LYK +
Sbjct: 371 NLASCYLKQGKYQDAETLYKEIL 393
Score = 119 bits (299), Expect = 1e-26
Identities = 82/246 (33%), Positives = 120/246 (48%), Gaps = 25/246 (10%)
Query: 1013 EISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFAL 1072
++S G + P R L L Y Q +YE A
Sbjct: 184 DVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVA------------------------VP 219
Query: 1073 LRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHP 1132
L ++AL+ E T G D PD A LN L ++Y QN + A L +L +RE+ LG DHP
Sbjct: 220 LCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHP 279
Query: 1133 DCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGK 1192
A +LNNLA L ++ +Y +AE L +RAL+IR + L HP +A + +LA+L + GK
Sbjct: 280 AVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGK 339
Query: 1193 LDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL-KIYED 1251
++ Y A+EI GP P+VA NLA Y + K+ +A LY+ L + +E
Sbjct: 340 AEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEK 399
Query: 1252 SLGRMH 1257
G ++
Sbjct: 400 EFGSVN 405
Score = 115 bits (287), Expect = 4e-25
Identities = 91/295 (30%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E DHP VA L+ LA VY K+ A L AL I E
Sbjct: 215 EVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTL 274
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G DHP A L LA LY K+ KY++AE L +RAL+
Sbjct: 275 GKDHPAVAATLNNLAVLYGKRGKYKEAEP------------------------LCKRALE 310
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+ E LGK PD A+ L+ L +L Q E + + +R+LE+ LGPD P+ A++ N
Sbjct: 311 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKN 370
Query: 1140 NLAALCNEKKQYDKAEELY-----------------------------ERALDIRR---- 1166
NLA+ ++ +Y AE LY E + D RR
Sbjct: 371 NLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKPIWMHAEEREESKDKRRDSAP 430
Query: 1167 --------RALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGP 1213
+A D P++ T++ L LY++ GKL+ A L + A R++ P
Sbjct: 431 YGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRNRKQGLDP 485
Score = 108 bits (271), Expect = 3e-23
Identities = 63/163 (38%), Positives = 94/163 (57%)
Query: 1128 GPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILY 1187
G + P ++L+NL + +Y+ A L ++AL+ + DHP +A + LA++Y
Sbjct: 191 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 250
Query: 1188 KKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALK 1247
+ K +A L A+ IR+K+ G HP+VA L NLAVLY + K+ EA PL +RAL+
Sbjct: 251 RDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE 310
Query: 1248 IYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEI 1290
I E LG+ HP V + L NLA+L G E+ Y+RA+EI
Sbjct: 311 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEI 353
Score = 90.1 bits (222), Expect = 1e-17
Identities = 52/119 (43%), Positives = 72/119 (60%)
Query: 1174 PSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMK 1233
P+ T+ +L I Y G+ + AVPL + A+E +K+ G HP VAT L LA++Y
Sbjct: 195 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 254
Query: 1234 KHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKE 1292
K+ EA L AL I E +LG+ HP V TL NLAVL + G +++A L KRA+EI+E
Sbjct: 255 KYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIRE 313
Score = 43.1 bits (100), Expect = 0.002
Identities = 25/81 (30%), Positives = 44/81 (54%)
Query: 1212 GPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLS 1271
G + P+ L NL + Y+ ++ A+PL ++AL+ E + G HP V L LA++
Sbjct: 191 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 250
Query: 1272 YEGGDFEKAAELYKRAMEIKE 1292
+ +++AA L A+ I+E
Sbjct: 251 RDQNKYKEAAHLLNDALAIRE 271
>gi|198041731 kinesin light chain 2 isoform 1 [Homo sapiens]
Length = 622
Score = 146 bits (369), Expect = 1e-34
Identities = 108/308 (35%), Positives = 144/308 (46%), Gaps = 37/308 (12%)
Query: 982 PRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQN 1041
P ++LH L Y ++ A L KQALE E G DHP A L LA +Y+ QN
Sbjct: 195 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 254
Query: 1042 KYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGV 1101
KY++A H L AL + E TLGKD P A TLN L V
Sbjct: 255 KYKEAAH------------------------LLNDALAIREKTLGKDHPAVAATLNNLAV 290
Query: 1102 LYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERA 1161
LY + + A+ KR+LE+RE+VLG HPD A+ L+NLA LC + + ++ E Y RA
Sbjct: 291 LYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRA 350
Query: 1162 LDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY-ELAVEIRQKSFGPKHPSVAT 1220
L+I L PD P++A T +LA Y K GK A LY E+ +K FG +
Sbjct: 351 LEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKP 410
Query: 1221 ALVNLAVLYSQMKKHVEALPLYE-----RALKIYEDSLGRMHPRVGETLKNLAVLSYEGG 1275
++ K ++ P E +A K+ DS P V TL++L L G
Sbjct: 411 IWMHAEEREESKDKRRDSAPYGEYGSWYKACKV--DS-----PTVNTTLRSLGALYRRQG 463
Query: 1276 DFEKAAEL 1283
E A L
Sbjct: 464 KLEAAHTL 471
Score = 141 bits (355), Expect = 5e-33
Identities = 83/203 (40%), Positives = 111/203 (54%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE E+ G DHPD A LN LA +
Sbjct: 191 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 250
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y +A L AL IR + L DHP++A T+ +LA+LY K GK +A PL + A+E
Sbjct: 251 RDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE 310
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K E Y RAL+IY LG P V +T
Sbjct: 311 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKN 370
Query: 1266 NLAVLSYEGGDFEKAAELYKRAM 1288
NLA + G ++ A LYK +
Sbjct: 371 NLASCYLKQGKYQDAETLYKEIL 393
Score = 119 bits (299), Expect = 1e-26
Identities = 82/246 (33%), Positives = 120/246 (48%), Gaps = 25/246 (10%)
Query: 1013 EISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFAL 1072
++S G + P R L L Y Q +YE A
Sbjct: 184 DVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVA------------------------VP 219
Query: 1073 LRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHP 1132
L ++AL+ E T G D PD A LN L ++Y QN + A L +L +RE+ LG DHP
Sbjct: 220 LCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHP 279
Query: 1133 DCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGK 1192
A +LNNLA L ++ +Y +AE L +RAL+IR + L HP +A + +LA+L + GK
Sbjct: 280 AVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGK 339
Query: 1193 LDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL-KIYED 1251
++ Y A+EI GP P+VA NLA Y + K+ +A LY+ L + +E
Sbjct: 340 AEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEK 399
Query: 1252 SLGRMH 1257
G ++
Sbjct: 400 EFGSVN 405
Score = 115 bits (287), Expect = 4e-25
Identities = 91/295 (30%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E DHP VA L+ LA VY K+ A L AL I E
Sbjct: 215 EVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTL 274
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G DHP A L LA LY K+ KY++AE L +RAL+
Sbjct: 275 GKDHPAVAATLNNLAVLYGKRGKYKEAEP------------------------LCKRALE 310
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+ E LGK PD A+ L+ L +L Q E + + +R+LE+ LGPD P+ A++ N
Sbjct: 311 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKN 370
Query: 1140 NLAALCNEKKQYDKAEELY-----------------------------ERALDIRR---- 1166
NLA+ ++ +Y AE LY E + D RR
Sbjct: 371 NLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKPIWMHAEEREESKDKRRDSAP 430
Query: 1167 --------RALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGP 1213
+A D P++ T++ L LY++ GKL+ A L + A R++ P
Sbjct: 431 YGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRNRKQGLDP 485
Score = 108 bits (271), Expect = 3e-23
Identities = 63/163 (38%), Positives = 94/163 (57%)
Query: 1128 GPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILY 1187
G + P ++L+NL + +Y+ A L ++AL+ + DHP +A + LA++Y
Sbjct: 191 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 250
Query: 1188 KKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALK 1247
+ K +A L A+ IR+K+ G HP+VA L NLAVLY + K+ EA PL +RAL+
Sbjct: 251 RDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE 310
Query: 1248 IYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEI 1290
I E LG+ HP V + L NLA+L G E+ Y+RA+EI
Sbjct: 311 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEI 353
Score = 90.1 bits (222), Expect = 1e-17
Identities = 52/119 (43%), Positives = 72/119 (60%)
Query: 1174 PSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMK 1233
P+ T+ +L I Y G+ + AVPL + A+E +K+ G HP VAT L LA++Y
Sbjct: 195 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 254
Query: 1234 KHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKE 1292
K+ EA L AL I E +LG+ HP V TL NLAVL + G +++A L KRA+EI+E
Sbjct: 255 KYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIRE 313
Score = 43.1 bits (100), Expect = 0.002
Identities = 25/81 (30%), Positives = 44/81 (54%)
Query: 1212 GPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLS 1271
G + P+ L NL + Y+ ++ A+PL ++AL+ E + G HP V L LA++
Sbjct: 191 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 250
Query: 1272 YEGGDFEKAAELYKRAMEIKE 1292
+ +++AA L A+ I+E
Sbjct: 251 RDQNKYKEAAHLLNDALAIRE 271
>gi|198041728 kinesin light chain 2 isoform 2 [Homo sapiens]
Length = 545
Score = 146 bits (369), Expect = 1e-34
Identities = 108/308 (35%), Positives = 144/308 (46%), Gaps = 37/308 (12%)
Query: 982 PRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQN 1041
P ++LH L Y ++ A L KQALE E G DHP A L LA +Y+ QN
Sbjct: 118 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 177
Query: 1042 KYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGV 1101
KY++A H L AL + E TLGKD P A TLN L V
Sbjct: 178 KYKEAAH------------------------LLNDALAIREKTLGKDHPAVAATLNNLAV 213
Query: 1102 LYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERA 1161
LY + + A+ KR+LE+RE+VLG HPD A+ L+NLA LC + + ++ E Y RA
Sbjct: 214 LYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRA 273
Query: 1162 LDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY-ELAVEIRQKSFGPKHPSVAT 1220
L+I L PD P++A T +LA Y K GK A LY E+ +K FG +
Sbjct: 274 LEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKP 333
Query: 1221 ALVNLAVLYSQMKKHVEALPLYE-----RALKIYEDSLGRMHPRVGETLKNLAVLSYEGG 1275
++ K ++ P E +A K+ DS P V TL++L L G
Sbjct: 334 IWMHAEEREESKDKRRDSAPYGEYGSWYKACKV--DS-----PTVNTTLRSLGALYRRQG 386
Query: 1276 DFEKAAEL 1283
E A L
Sbjct: 387 KLEAAHTL 394
Score = 141 bits (355), Expect = 5e-33
Identities = 83/203 (40%), Positives = 111/203 (54%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE E+ G DHPD A LN LA +
Sbjct: 114 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 173
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y +A L AL IR + L DHP++A T+ +LA+LY K GK +A PL + A+E
Sbjct: 174 RDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE 233
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K E Y RAL+IY LG P V +T
Sbjct: 234 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKN 293
Query: 1266 NLAVLSYEGGDFEKAAELYKRAM 1288
NLA + G ++ A LYK +
Sbjct: 294 NLASCYLKQGKYQDAETLYKEIL 316
Score = 119 bits (299), Expect = 1e-26
Identities = 82/246 (33%), Positives = 120/246 (48%), Gaps = 25/246 (10%)
Query: 1013 EISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFAL 1072
++S G + P R L L Y Q +YE A
Sbjct: 107 DVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVA------------------------VP 142
Query: 1073 LRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHP 1132
L ++AL+ E T G D PD A LN L ++Y QN + A L +L +RE+ LG DHP
Sbjct: 143 LCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHP 202
Query: 1133 DCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGK 1192
A +LNNLA L ++ +Y +AE L +RAL+IR + L HP +A + +LA+L + GK
Sbjct: 203 AVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGK 262
Query: 1193 LDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL-KIYED 1251
++ Y A+EI GP P+VA NLA Y + K+ +A LY+ L + +E
Sbjct: 263 AEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEK 322
Query: 1252 SLGRMH 1257
G ++
Sbjct: 323 EFGSVN 328
Score = 115 bits (287), Expect = 4e-25
Identities = 91/295 (30%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E DHP VA L+ LA VY K+ A L AL I E
Sbjct: 138 EVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTL 197
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G DHP A L LA LY K+ KY++AE L +RAL+
Sbjct: 198 GKDHPAVAATLNNLAVLYGKRGKYKEAEP------------------------LCKRALE 233
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+ E LGK PD A+ L+ L +L Q E + + +R+LE+ LGPD P+ A++ N
Sbjct: 234 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKN 293
Query: 1140 NLAALCNEKKQYDKAEELY-----------------------------ERALDIRR---- 1166
NLA+ ++ +Y AE LY E + D RR
Sbjct: 294 NLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKPIWMHAEEREESKDKRRDSAP 353
Query: 1167 --------RALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGP 1213
+A D P++ T++ L LY++ GKL+ A L + A R++ P
Sbjct: 354 YGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRNRKQGLDP 408
Score = 110 bits (274), Expect = 1e-23
Identities = 78/225 (34%), Positives = 120/225 (53%), Gaps = 13/225 (5%)
Query: 1072 LLRRRALQLEELTLGK------DTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRER 1125
+L RR+L+ EL LG+ D P + TL++L N E + ++ +
Sbjct: 59 ILLRRSLEAIELGLGEAQEEKGDVPKD--TLDDL-----FPNEDEQSPAPSPGGGDVSGQ 111
Query: 1126 VLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAI 1185
G + P ++L+NL + +Y+ A L ++AL+ + DHP +A + LA+
Sbjct: 112 HGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILAL 171
Query: 1186 LYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERA 1245
+Y+ K +A L A+ IR+K+ G HP+VA L NLAVLY + K+ EA PL +RA
Sbjct: 172 VYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRA 231
Query: 1246 LKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEI 1290
L+I E LG+ HP V + L NLA+L G E+ Y+RA+EI
Sbjct: 232 LEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEI 276
Score = 90.1 bits (222), Expect = 1e-17
Identities = 52/119 (43%), Positives = 72/119 (60%)
Query: 1174 PSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMK 1233
P+ T+ +L I Y G+ + AVPL + A+E +K+ G HP VAT L LA++Y
Sbjct: 118 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 177
Query: 1234 KHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKE 1292
K+ EA L AL I E +LG+ HP V TL NLAVL + G +++A L KRA+EI+E
Sbjct: 178 KYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIRE 236
Score = 43.1 bits (100), Expect = 0.002
Identities = 25/81 (30%), Positives = 44/81 (54%)
Query: 1212 GPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLS 1271
G + P+ L NL + Y+ ++ A+PL ++AL+ E + G HP V L LA++
Sbjct: 114 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 173
Query: 1272 YEGGDFEKAAELYKRAMEIKE 1292
+ +++AA L A+ I+E
Sbjct: 174 RDQNKYKEAAHLLNDALAIRE 194
>gi|12383062 kinesin light chain 2 isoform 1 [Homo sapiens]
Length = 622
Score = 146 bits (369), Expect = 1e-34
Identities = 108/308 (35%), Positives = 144/308 (46%), Gaps = 37/308 (12%)
Query: 982 PRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQN 1041
P ++LH L Y ++ A L KQALE E G DHP A L LA +Y+ QN
Sbjct: 195 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 254
Query: 1042 KYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGV 1101
KY++A H L AL + E TLGKD P A TLN L V
Sbjct: 255 KYKEAAH------------------------LLNDALAIREKTLGKDHPAVAATLNNLAV 290
Query: 1102 LYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERA 1161
LY + + A+ KR+LE+RE+VLG HPD A+ L+NLA LC + + ++ E Y RA
Sbjct: 291 LYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRA 350
Query: 1162 LDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLY-ELAVEIRQKSFGPKHPSVAT 1220
L+I L PD P++A T +LA Y K GK A LY E+ +K FG +
Sbjct: 351 LEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKP 410
Query: 1221 ALVNLAVLYSQMKKHVEALPLYE-----RALKIYEDSLGRMHPRVGETLKNLAVLSYEGG 1275
++ K ++ P E +A K+ DS P V TL++L L G
Sbjct: 411 IWMHAEEREESKDKRRDSAPYGEYGSWYKACKV--DS-----PTVNTTLRSLGALYRRQG 463
Query: 1276 DFEKAAEL 1283
E A L
Sbjct: 464 KLEAAHTL 471
Score = 141 bits (355), Expect = 5e-33
Identities = 83/203 (40%), Positives = 111/203 (54%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE E+ G DHPD A LN LA +
Sbjct: 191 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 250
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y +A L AL IR + L DHP++A T+ +LA+LY K GK +A PL + A+E
Sbjct: 251 RDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE 310
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K E Y RAL+IY LG P V +T
Sbjct: 311 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKN 370
Query: 1266 NLAVLSYEGGDFEKAAELYKRAM 1288
NLA + G ++ A LYK +
Sbjct: 371 NLASCYLKQGKYQDAETLYKEIL 393
Score = 119 bits (299), Expect = 1e-26
Identities = 82/246 (33%), Positives = 120/246 (48%), Gaps = 25/246 (10%)
Query: 1013 EISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFAL 1072
++S G + P R L L Y Q +YE A
Sbjct: 184 DVSGQHGGYEIPARLRTLHNLVIQYASQGRYEVA------------------------VP 219
Query: 1073 LRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHP 1132
L ++AL+ E T G D PD A LN L ++Y QN + A L +L +RE+ LG DHP
Sbjct: 220 LCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTLGKDHP 279
Query: 1133 DCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGK 1192
A +LNNLA L ++ +Y +AE L +RAL+IR + L HP +A + +LA+L + GK
Sbjct: 280 AVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGK 339
Query: 1193 LDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL-KIYED 1251
++ Y A+EI GP P+VA NLA Y + K+ +A LY+ L + +E
Sbjct: 340 AEEVEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEK 399
Query: 1252 SLGRMH 1257
G ++
Sbjct: 400 EFGSVN 405
Score = 115 bits (287), Expect = 4e-25
Identities = 91/295 (30%), Positives = 130/295 (44%), Gaps = 66/295 (22%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E DHP VA L+ LA VY K+ A L AL I E
Sbjct: 215 EVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAAHLLNDALAIREKTL 274
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G DHP A L LA LY K+ KY++AE L +RAL+
Sbjct: 275 GKDHPAVAATLNNLAVLYGKRGKYKEAEP------------------------LCKRALE 310
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+ E LGK PD A+ L+ L +L Q E + + +R+LE+ LGPD P+ A++ N
Sbjct: 311 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNVAKTKN 370
Query: 1140 NLAALCNEKKQYDKAEELY-----------------------------ERALDIRR---- 1166
NLA+ ++ +Y AE LY E + D RR
Sbjct: 371 NLASCYLKQGKYQDAETLYKEILTRAHEKEFGSVNGDNKPIWMHAEEREESKDKRRDSAP 430
Query: 1167 --------RALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGP 1213
+A D P++ T++ L LY++ GKL+ A L + A R++ P
Sbjct: 431 YGEYGSWYKACKVDSPTVNTTLRSLGALYRRQGKLEAAHTLEDCASRNRKQGLDP 485
Score = 108 bits (271), Expect = 3e-23
Identities = 63/163 (38%), Positives = 94/163 (57%)
Query: 1128 GPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILY 1187
G + P ++L+NL + +Y+ A L ++AL+ + DHP +A + LA++Y
Sbjct: 191 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 250
Query: 1188 KKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALK 1247
+ K +A L A+ IR+K+ G HP+VA L NLAVLY + K+ EA PL +RAL+
Sbjct: 251 RDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE 310
Query: 1248 IYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEI 1290
I E LG+ HP V + L NLA+L G E+ Y+RA+EI
Sbjct: 311 IREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEI 353
Score = 90.1 bits (222), Expect = 1e-17
Identities = 52/119 (43%), Positives = 72/119 (60%)
Query: 1174 PSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMK 1233
P+ T+ +L I Y G+ + AVPL + A+E +K+ G HP VAT L LA++Y
Sbjct: 195 PARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQN 254
Query: 1234 KHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKE 1292
K+ EA L AL I E +LG+ HP V TL NLAVL + G +++A L KRA+EI+E
Sbjct: 255 KYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIRE 313
Score = 43.1 bits (100), Expect = 0.002
Identities = 25/81 (30%), Positives = 44/81 (54%)
Query: 1212 GPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLS 1271
G + P+ L NL + Y+ ++ A+PL ++AL+ E + G HP V L LA++
Sbjct: 191 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 250
Query: 1272 YEGGDFEKAAELYKRAMEIKE 1292
+ +++AA L A+ I+E
Sbjct: 251 RDQNKYKEAAHLLNDALAIRE 271
>gi|194306559 kinesin light chain 1 isoform 3 [Homo sapiens]
Length = 618
Score = 146 bits (368), Expect = 1e-34
Identities = 84/203 (41%), Positives = 114/203 (56%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE E+ G DHPD A LN LA +
Sbjct: 206 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 265
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y A L AL IR + L DHP++A T+ +LA+LY K GK +A PL + A+E
Sbjct: 266 RDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE 325
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K+ E Y+RAL+IY+ LG P V +T
Sbjct: 326 IREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKN 385
Query: 1266 NLAVLSYEGGDFEKAAELYKRAM 1288
NLA + G F++A LYK +
Sbjct: 386 NLASCYLKQGKFKQAETLYKEIL 408
Score = 127 bits (318), Expect = 9e-29
Identities = 100/314 (31%), Positives = 137/314 (43%), Gaps = 65/314 (20%)
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G + P R L L Y Q +YE A L ++AL+
Sbjct: 206 GYEIPARLRTLHNLVIQYASQGRYEVA------------------------VPLCKQALE 241
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
E T G D PD A LN L ++Y QN + A L +L +RE+ LG DHP A +LN
Sbjct: 242 DLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLN 301
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPL 1199
NLA L ++ +Y +AE L +RAL+IR + L DHP +A + +LA+L + GK ++
Sbjct: 302 NLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYY 361
Query: 1200 YELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL-KIYEDSLGR--- 1255
Y+ A+EI Q GP P+VA NLA Y + K +A LY+ L + +E G
Sbjct: 362 YQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDD 421
Query: 1256 ------MH-------------------------------PRVGETLKNLAVLSYEGGDFE 1278
MH P V TLKNL L G FE
Sbjct: 422 ENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFE 481
Query: 1279 KAAELYKRAMEIKE 1292
A L + AM ++
Sbjct: 482 AAETLEEAAMRSRK 495
Score = 123 bits (309), Expect = 1e-27
Identities = 107/335 (31%), Positives = 151/335 (45%), Gaps = 49/335 (14%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E DHP VA L+ LA VY K+ +A L AL I E
Sbjct: 230 EVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTL 289
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G DHP A L LA LY K+ KY++AE L +RAL+
Sbjct: 290 GKDHPAVAATLNNLAVLYGKRGKYKEAEP------------------------LCKRALE 325
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+ E LGKD PD A+ LN L +L Q E + + +R+LE+ + LGPD P+ A++ N
Sbjct: 326 IREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKN 385
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVK----HLAILYKKMGKLDK 1195
NLA+ ++ ++ +AE LY+ +I RA + S+ K H + GK
Sbjct: 386 NLASCYLKQGKFKQAETLYK---EILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKD 442
Query: 1196 AVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGR 1255
E K+ P+V T L NL LY + K A L E A++ + L
Sbjct: 443 GTSFGEYGG--WYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDN 500
Query: 1256 MH-PRVGETLK--------------NLAVLSYEGG 1275
+H RV E L N+ V+ YE G
Sbjct: 501 VHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESG 535
Score = 112 bits (280), Expect = 2e-24
Identities = 114/399 (28%), Positives = 181/399 (45%), Gaps = 40/399 (10%)
Query: 905 LSYWQFVGKDKSAMAT--EYFDSLKQYEKNCEG--EDNMSCLADLYETLGRFLKD--LGL 958
+S ++ +DK T E KQ + E ++ S L L ETL KD L
Sbjct: 5 MSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNL 64
Query: 959 LSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENA 1018
+ + +++SLE+ E L +A S H NA + KQ L
Sbjct: 65 VEEKSNMIRKSLEMLELGLSEAQVMMALSNHL------------NAVESEKQKLRAQVRR 112
Query: 1019 YGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRAL 1078
++ + EL A QK K EQ+ + Q +KK +L L++
Sbjct: 113 LCQENQWLRDEL---ANTQQKLQKSEQS---------VAQLEEEKK-HLEFMNQLKKYDD 159
Query: 1079 QLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKR---SLEMRERVLGPDHPDCA 1135
+ + KDT L++L N+ + Q +++ S + G + P
Sbjct: 160 DISP-SEDKDTDSTKEPLDDL-----FPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARL 213
Query: 1136 QSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDK 1195
++L+NL + +Y+ A L ++AL+ + DHP +A + LA++Y+ K
Sbjct: 214 RTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKD 273
Query: 1196 AVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGR 1255
A L A+ IR+K+ G HP+VA L NLAVLY + K+ EA PL +RAL+I E LG+
Sbjct: 274 AANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGK 333
Query: 1256 MHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAE 1294
HP V + L NLA+L G +E+ Y+RA+EI + +
Sbjct: 334 DHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTK 372
Score = 106 bits (264), Expect = 2e-22
Identities = 88/304 (28%), Positives = 134/304 (44%), Gaps = 35/304 (11%)
Query: 925 SLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRV 984
+L+ EK G D+ +A + L +D A L +L IRE L DHP V
Sbjct: 239 ALEDLEKT-SGHDHPD-VATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAV 296
Query: 985 AQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYE 1044
A +L+ LA +Y + K+ AE L K+ALEI E G DHP A++L LA L Q Q KYE
Sbjct: 297 AATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYE 356
Query: 1045 QAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYY 1104
+ E++ +RAL++ + LG D P+ A+T N L Y
Sbjct: 357 EVEYY------------------------YQRALEIYQTKLGPDDPNVAKTKNNLASCYL 392
Query: 1105 LQNNLETADQFLKRSL-EMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALD 1163
Q + A+ K L ER G N + E+++ K ++ +
Sbjct: 393 KQGKFKQAETLYKEILTRAHEREFG-----SVDDENKPIWMHAEEREECKGKQKDGTSFG 447
Query: 1164 IR---RRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVAT 1220
+A D P++ T+K+L LY++ GK + A L E A+ R++ H
Sbjct: 448 EYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVA 507
Query: 1221 ALVN 1224
++N
Sbjct: 508 EVLN 511
>gi|110735431 kinesin light chain 1 isoform 2 [Homo sapiens]
Length = 573
Score = 146 bits (368), Expect = 1e-34
Identities = 84/203 (41%), Positives = 114/203 (56%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE E+ G DHPD A LN LA +
Sbjct: 206 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 265
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y A L AL IR + L DHP++A T+ +LA+LY K GK +A PL + A+E
Sbjct: 266 RDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE 325
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K+ E Y+RAL+IY+ LG P V +T
Sbjct: 326 IREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKN 385
Query: 1266 NLAVLSYEGGDFEKAAELYKRAM 1288
NLA + G F++A LYK +
Sbjct: 386 NLASCYLKQGKFKQAETLYKEIL 408
Score = 127 bits (318), Expect = 9e-29
Identities = 100/314 (31%), Positives = 137/314 (43%), Gaps = 65/314 (20%)
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G + P R L L Y Q +YE A L ++AL+
Sbjct: 206 GYEIPARLRTLHNLVIQYASQGRYEVA------------------------VPLCKQALE 241
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
E T G D PD A LN L ++Y QN + A L +L +RE+ LG DHP A +LN
Sbjct: 242 DLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLN 301
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPL 1199
NLA L ++ +Y +AE L +RAL+IR + L DHP +A + +LA+L + GK ++
Sbjct: 302 NLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYY 361
Query: 1200 YELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL-KIYEDSLGR--- 1255
Y+ A+EI Q GP P+VA NLA Y + K +A LY+ L + +E G
Sbjct: 362 YQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDD 421
Query: 1256 ------MH-------------------------------PRVGETLKNLAVLSYEGGDFE 1278
MH P V TLKNL L G FE
Sbjct: 422 ENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFE 481
Query: 1279 KAAELYKRAMEIKE 1292
A L + AM ++
Sbjct: 482 AAETLEEAAMRSRK 495
Score = 123 bits (309), Expect = 1e-27
Identities = 107/335 (31%), Positives = 151/335 (45%), Gaps = 49/335 (14%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E DHP VA L+ LA VY K+ +A L AL I E
Sbjct: 230 EVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTL 289
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G DHP A L LA LY K+ KY++AE L +RAL+
Sbjct: 290 GKDHPAVAATLNNLAVLYGKRGKYKEAEP------------------------LCKRALE 325
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+ E LGKD PD A+ LN L +L Q E + + +R+LE+ + LGPD P+ A++ N
Sbjct: 326 IREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKN 385
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVK----HLAILYKKMGKLDK 1195
NLA+ ++ ++ +AE LY+ +I RA + S+ K H + GK
Sbjct: 386 NLASCYLKQGKFKQAETLYK---EILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKD 442
Query: 1196 AVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGR 1255
E K+ P+V T L NL LY + K A L E A++ + L
Sbjct: 443 GTSFGEYGG--WYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDN 500
Query: 1256 MH-PRVGETLK--------------NLAVLSYEGG 1275
+H RV E L N+ V+ YE G
Sbjct: 501 VHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESG 535
Score = 112 bits (280), Expect = 2e-24
Identities = 114/399 (28%), Positives = 181/399 (45%), Gaps = 40/399 (10%)
Query: 905 LSYWQFVGKDKSAMAT--EYFDSLKQYEKNCEG--EDNMSCLADLYETLGRFLKD--LGL 958
+S ++ +DK T E KQ + E ++ S L L ETL KD L
Sbjct: 5 MSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNL 64
Query: 959 LSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENA 1018
+ + +++SLE+ E L +A S H NA + KQ L
Sbjct: 65 VEEKSNMIRKSLEMLELGLSEAQVMMALSNHL------------NAVESEKQKLRAQVRR 112
Query: 1019 YGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRAL 1078
++ + EL A QK K EQ+ + Q +KK +L L++
Sbjct: 113 LCQENQWLRDEL---ANTQQKLQKSEQS---------VAQLEEEKK-HLEFMNQLKKYDD 159
Query: 1079 QLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKR---SLEMRERVLGPDHPDCA 1135
+ + KDT L++L N+ + Q +++ S + G + P
Sbjct: 160 DISP-SEDKDTDSTKEPLDDL-----FPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARL 213
Query: 1136 QSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDK 1195
++L+NL + +Y+ A L ++AL+ + DHP +A + LA++Y+ K
Sbjct: 214 RTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKD 273
Query: 1196 AVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGR 1255
A L A+ IR+K+ G HP+VA L NLAVLY + K+ EA PL +RAL+I E LG+
Sbjct: 274 AANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGK 333
Query: 1256 MHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAE 1294
HP V + L NLA+L G +E+ Y+RA+EI + +
Sbjct: 334 DHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTK 372
Score = 106 bits (264), Expect = 2e-22
Identities = 88/304 (28%), Positives = 134/304 (44%), Gaps = 35/304 (11%)
Query: 925 SLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRV 984
+L+ EK G D+ +A + L +D A L +L IRE L DHP V
Sbjct: 239 ALEDLEKT-SGHDHPD-VATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAV 296
Query: 985 AQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYE 1044
A +L+ LA +Y + K+ AE L K+ALEI E G DHP A++L LA L Q Q KYE
Sbjct: 297 AATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYE 356
Query: 1045 QAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYY 1104
+ E++ +RAL++ + LG D P+ A+T N L Y
Sbjct: 357 EVEYY------------------------YQRALEIYQTKLGPDDPNVAKTKNNLASCYL 392
Query: 1105 LQNNLETADQFLKRSL-EMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALD 1163
Q + A+ K L ER G N + E+++ K ++ +
Sbjct: 393 KQGKFKQAETLYKEILTRAHEREFG-----SVDDENKPIWMHAEEREECKGKQKDGTSFG 447
Query: 1164 IR---RRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVAT 1220
+A D P++ T+K+L LY++ GK + A L E A+ R++ H
Sbjct: 448 EYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVA 507
Query: 1221 ALVN 1224
++N
Sbjct: 508 EVLN 511
>gi|33620730 kinesin light chain 1 isoform 1 [Homo sapiens]
Length = 560
Score = 146 bits (368), Expect = 1e-34
Identities = 84/203 (41%), Positives = 114/203 (56%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE E+ G DHPD A LN LA +
Sbjct: 206 GYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVY 265
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y A L AL IR + L DHP++A T+ +LA+LY K GK +A PL + A+E
Sbjct: 266 RDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALE 325
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K+ E Y+RAL+IY+ LG P V +T
Sbjct: 326 IREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKN 385
Query: 1266 NLAVLSYEGGDFEKAAELYKRAM 1288
NLA + G F++A LYK +
Sbjct: 386 NLASCYLKQGKFKQAETLYKEIL 408
Score = 127 bits (318), Expect = 9e-29
Identities = 100/314 (31%), Positives = 137/314 (43%), Gaps = 65/314 (20%)
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G + P R L L Y Q +YE A L ++AL+
Sbjct: 206 GYEIPARLRTLHNLVIQYASQGRYEVA------------------------VPLCKQALE 241
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
E T G D PD A LN L ++Y QN + A L +L +RE+ LG DHP A +LN
Sbjct: 242 DLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLN 301
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPL 1199
NLA L ++ +Y +AE L +RAL+IR + L DHP +A + +LA+L + GK ++
Sbjct: 302 NLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYY 361
Query: 1200 YELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL-KIYEDSLGR--- 1255
Y+ A+EI Q GP P+VA NLA Y + K +A LY+ L + +E G
Sbjct: 362 YQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDD 421
Query: 1256 ------MH-------------------------------PRVGETLKNLAVLSYEGGDFE 1278
MH P V TLKNL L G FE
Sbjct: 422 ENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFE 481
Query: 1279 KAAELYKRAMEIKE 1292
A L + AM ++
Sbjct: 482 AAETLEEAAMRSRK 495
Score = 123 bits (309), Expect = 1e-27
Identities = 107/335 (31%), Positives = 151/335 (45%), Gaps = 49/335 (14%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E DHP VA L+ LA VY K+ +A L AL I E
Sbjct: 230 EVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTL 289
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G DHP A L LA LY K+ KY++AE L +RAL+
Sbjct: 290 GKDHPAVAATLNNLAVLYGKRGKYKEAEP------------------------LCKRALE 325
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+ E LGKD PD A+ LN L +L Q E + + +R+LE+ + LGPD P+ A++ N
Sbjct: 326 IREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKN 385
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVK----HLAILYKKMGKLDK 1195
NLA+ ++ ++ +AE LY+ +I RA + S+ K H + GK
Sbjct: 386 NLASCYLKQGKFKQAETLYK---EILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKD 442
Query: 1196 AVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGR 1255
E K+ P+V T L NL LY + K A L E A++ + L
Sbjct: 443 GTSFGEYGG--WYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDN 500
Query: 1256 MH-PRVGETLK--------------NLAVLSYEGG 1275
+H RV E L N+ V+ YE G
Sbjct: 501 VHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESG 535
Score = 112 bits (280), Expect = 2e-24
Identities = 114/399 (28%), Positives = 181/399 (45%), Gaps = 40/399 (10%)
Query: 905 LSYWQFVGKDKSAMAT--EYFDSLKQYEKNCEG--EDNMSCLADLYETLGRFLKD--LGL 958
+S ++ +DK T E KQ + E ++ S L L ETL KD L
Sbjct: 5 MSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNL 64
Query: 959 LSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENA 1018
+ + +++SLE+ E L +A S H NA + KQ L
Sbjct: 65 VEEKSNMIRKSLEMLELGLSEAQVMMALSNHL------------NAVESEKQKLRAQVRR 112
Query: 1019 YGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRAL 1078
++ + EL A QK K EQ+ + Q +KK +L L++
Sbjct: 113 LCQENQWLRDEL---ANTQQKLQKSEQS---------VAQLEEEKK-HLEFMNQLKKYDD 159
Query: 1079 QLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKR---SLEMRERVLGPDHPDCA 1135
+ + KDT L++L N+ + Q +++ S + G + P
Sbjct: 160 DISP-SEDKDTDSTKEPLDDL-----FPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARL 213
Query: 1136 QSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDK 1195
++L+NL + +Y+ A L ++AL+ + DHP +A + LA++Y+ K
Sbjct: 214 RTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKD 273
Query: 1196 AVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGR 1255
A L A+ IR+K+ G HP+VA L NLAVLY + K+ EA PL +RAL+I E LG+
Sbjct: 274 AANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGK 333
Query: 1256 MHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAE 1294
HP V + L NLA+L G +E+ Y+RA+EI + +
Sbjct: 334 DHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTK 372
Score = 106 bits (264), Expect = 2e-22
Identities = 88/304 (28%), Positives = 134/304 (44%), Gaps = 35/304 (11%)
Query: 925 SLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRV 984
+L+ EK G D+ +A + L +D A L +L IRE L DHP V
Sbjct: 239 ALEDLEKT-SGHDHPD-VATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAV 296
Query: 985 AQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYE 1044
A +L+ LA +Y + K+ AE L K+ALEI E G DHP A++L LA L Q Q KYE
Sbjct: 297 AATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYE 356
Query: 1045 QAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYY 1104
+ E++ +RAL++ + LG D P+ A+T N L Y
Sbjct: 357 EVEYY------------------------YQRALEIYQTKLGPDDPNVAKTKNNLASCYL 392
Query: 1105 LQNNLETADQFLKRSL-EMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALD 1163
Q + A+ K L ER G N + E+++ K ++ +
Sbjct: 393 KQGKFKQAETLYKEILTRAHEREFG-----SVDDENKPIWMHAEEREECKGKQKDGTSFG 447
Query: 1164 IR---RRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVAT 1220
+A D P++ T+K+L LY++ GK + A L E A+ R++ H
Sbjct: 448 EYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVA 507
Query: 1221 ALVN 1224
++N
Sbjct: 508 EVLN 511
>gi|91825557 kinesin light chain 3 [Homo sapiens]
Length = 504
Score = 136 bits (342), Expect = 2e-31
Identities = 81/212 (38%), Positives = 115/212 (54%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A +++LE ER G HPD A LN LA +
Sbjct: 200 GYEIPARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVY 259
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
++ +Y +A +L AL IR + L P+HP++A T+ +LA+LY K G+ +A PL + A+E
Sbjct: 260 RDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALE 319
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK 1265
IR+K G HP VA L NLA+L K + Y RAL IYE G P V +T
Sbjct: 320 IREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKN 379
Query: 1266 NLAVLSYEGGDFEKAAELYKRAMEIKEAETSL 1297
NLA + +++A ELYK + ++ L
Sbjct: 380 NLASAYLKQNKYQQAEELYKEILHKEDLPAPL 411
Score = 126 bits (316), Expect = 2e-28
Identities = 81/220 (36%), Positives = 109/220 (49%), Gaps = 24/220 (10%)
Query: 982 PRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQN 1041
P ++LH L Y ++ A L +QALE E + G HP A L LA +Y+ QN
Sbjct: 204 PARLRTLHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQN 263
Query: 1042 KYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGV 1101
KY++A L ALQ+ E TLG + P A TLN L V
Sbjct: 264 KYKEATD------------------------LLHDALQIREQTLGPEHPAVAATLNNLAV 299
Query: 1102 LYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERA 1161
LY + A+ +R+LE+RE+VLG DHPD A+ LNNLA LC + +++ E Y RA
Sbjct: 300 LYGKRGRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARA 359
Query: 1162 LDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYE 1201
L I P P++A T +LA Y K K +A LY+
Sbjct: 360 LSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYK 399
Score = 117 bits (294), Expect = 6e-26
Identities = 79/218 (36%), Positives = 115/218 (52%), Gaps = 6/218 (2%)
Query: 1031 EALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGN-LYGFAL-LRRRALQLEELTLGKD 1088
EA +Q YE R +H I+ G Y A+ L R+AL+ E + G
Sbjct: 189 EAAGAAAAQQGGYEIPARLRT----LHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHC 244
Query: 1089 TPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEK 1148
PD A LN L ++Y QN + A L +L++RE+ LGP+HP A +LNNLA L ++
Sbjct: 245 HPDVATMLNILALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKR 304
Query: 1149 KQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQ 1208
+Y +AE L +RAL+IR + L DHP +A + +LA+L + GK + Y A+ I +
Sbjct: 305 GRYREAEPLCQRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYE 364
Query: 1209 KSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL 1246
GP P+VA NLA Y + K+ +A LY+ L
Sbjct: 365 ALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEIL 402
Score = 86.7 bits (213), Expect = 1e-16
Identities = 64/221 (28%), Positives = 100/221 (45%), Gaps = 35/221 (15%)
Query: 909 QFVGKDKSAMAT----EYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIV 964
Q+ G+ + +A + + L++ +C + +A + L +D +A
Sbjct: 216 QYAGQGRYEVAVPLCRQALEDLERSSGHCHPD-----VATMLNILALVYRDQNKYKEATD 270
Query: 965 PLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHP 1024
L +L+IRE L P+HP VA +L+ LA +Y + ++ AE L ++ALEI E GADHP
Sbjct: 271 LLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGADHP 330
Query: 1025 YTARELEALATLYQKQNKYEQAE-HFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEEL 1083
A++L LA L Q Q K+E E H+ RAL + E
Sbjct: 331 DVAKQLNNLALLCQNQGKFEDVERHYA-------------------------RALSIYEA 365
Query: 1084 TLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRE 1124
G P+ A+T N L Y QN + A++ K L +
Sbjct: 366 LGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKED 406
Score = 44.7 bits (104), Expect = 6e-04
Identities = 36/123 (29%), Positives = 56/123 (45%), Gaps = 5/123 (4%)
Query: 968 RSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTA 1027
R+L I E P P VA++ + LAS Y++ K+ AE+LYK+ L + P T
Sbjct: 358 RALSIYEALGGPHDPNVAKTKNNLASAYLKQNKYQQAEELYKEILHKEDLPAPLGAPNTG 417
Query: 1028 RELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGK 1087
+A L + + + E R+ S K+ + +G A +RA+ L TL
Sbjct: 418 TAGDAEQALRRSSSLSKIRESIRRGSEKL---VSRLRGEAAAGAAGMKRAMSLN--TLNV 472
Query: 1088 DTP 1090
D P
Sbjct: 473 DAP 475
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 85.5 bits (210), Expect = 3e-16
Identities = 91/383 (23%), Positives = 170/383 (44%), Gaps = 42/383 (10%)
Query: 939 MSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQW 998
+S L +Y +G + L Q ++ ++S D A+ L + +VY+
Sbjct: 317 LSSLGHVYTAIGDYPNALASHKQCVLLAKQS---------KDELSEARELGNMGAVYIAM 367
Query: 999 KKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQ 1058
F NA Q ++Q L+I+++ + AR L + Y + +++A + ++ Q
Sbjct: 368 GDFENAVQCHEQHLKIAKDL--GNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQ 425
Query: 1059 KAIKKKGNLYGFALLRR---------RALQLEELTLG-----KDTPDNARTLNELGVLYY 1104
+ ++K + +A L RA Q E LG KD R + LG+++
Sbjct: 426 ELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQ 485
Query: 1105 LQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDI 1164
++ + +TA + K L + + + D+ ++ N+ N YD+A + + + L I
Sbjct: 486 MKGDYDTALKLHKTHLCIAQEL--SDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQI 543
Query: 1165 RRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYE----LAVEIRQKSFGPKHPSVAT 1220
D S A T +LA+ Y+ +G D+A+ Y+ +A E+R S A
Sbjct: 544 SMEV--NDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQ------SEAR 595
Query: 1221 ALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKA 1280
AL NL + ++V+A P YE+ L++ D L M G+ NL Y G++++A
Sbjct: 596 ALSNLGNFHCSRGEYVQAAPYYEQYLRLAPD-LQDMEGE-GKVCHNLGYAHYCLGNYQEA 653
Query: 1281 AELYKRAMEI-KEAETSLLGGKA 1302
+ Y++ + + K+ L KA
Sbjct: 654 VKYYEQDLALAKDLHDKLSQAKA 676
Score = 65.1 bits (157), Expect = 4e-10
Identities = 85/398 (21%), Positives = 169/398 (42%), Gaps = 46/398 (11%)
Query: 922 YFDSLKQYEKNCEGEDNMSCLADLYETLGRFLK--DLGLLSQAIVPLQRSLEIRETALDP 979
Y +++K YE++ ++ DL++ L + +LGL +A++ ++ E ++ L
Sbjct: 650 YQEAVKYYEQD------LALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLS- 702
Query: 980 DHPRVAQSLHQ----------LASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARE 1029
+AQSL+ L +++ K A + Y+Q L ++ D A
Sbjct: 703 ----LAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQV--KDRRLEASA 756
Query: 1030 LEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQL--------- 1080
AL T Y+ KY++A + + +++Q+ G L + L
Sbjct: 757 YAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKC 816
Query: 1081 --EELTLG---KDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHP-DC 1134
E+L LG KD A+ +G+ N +E A + ++ L M +++ G + D
Sbjct: 817 YEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDR 876
Query: 1135 AQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLD 1194
++ NL Y++A + YE+ L + + + AY + L ++ MG L
Sbjct: 877 GRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAY--RGLGNGHRAMGSLQ 934
Query: 1195 KAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLG 1254
+A+ +E + + + G + A A L L+SQ+ + +A+ ER L I D
Sbjct: 935 QALVCFEKRLVVAHE-LGEAF-NKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKD 992
Query: 1255 RMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKE 1292
R + L + + G+++ A + ++ ++I E
Sbjct: 993 R--ALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAE 1028
Score = 48.5 bits (114), Expect = 4e-05
Identities = 48/209 (22%), Positives = 92/209 (44%), Gaps = 23/209 (11%)
Query: 1094 RTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDK 1153
R L LG ++ + ++ A +F ++ L + +V D A + L ++YDK
Sbjct: 715 RALGNLGDIFICKKDINGAIKFYEQQLGLAHQV--KDRRLEASAYAALGTAYRMIQKYDK 772
Query: 1154 AEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGP 1213
A + + L++ + D P HLA +Y +GK A YE +++ QK
Sbjct: 773 ALGYHTQELEVYQEL--SDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKL--- 827
Query: 1214 KHPSV-ATALVNLAVLYSQMKKHVEALPLYERALKIYED--------SLGRMHPRVGETL 1264
K PS+ A N+ + M EA+ +E+ L + + GR + +G+
Sbjct: 828 KDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCY 887
Query: 1265 KNLAVLSYEGGDFEKAAELYKRAMEIKEA 1293
+ L GD+E+A + Y++ + + ++
Sbjct: 888 EAL-------GDYEEAIKYYEQYLSVAQS 909
Score = 40.0 bits (92), Expect = 0.015
Identities = 50/228 (21%), Positives = 97/228 (42%), Gaps = 31/228 (13%)
Query: 921 EYFDSLKQYEKNCEGEDNMSCLAD---LYETLGRFLKDLGLLSQAIVPLQRSLEIRETAL 977
+Y +++K YE+ +++ + D Y LG + +G L QA+V ++ L +
Sbjct: 892 DYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELG 951
Query: 978 DPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEA----- 1032
+ + AQ+ +L S++ Q GN Y+QA+ E R LE+
Sbjct: 952 EAFNK--AQAYGELGSLHSQ---LGN----YEQAISCLERQLNIARDMKDRALESDAACG 1002
Query: 1033 LATLYQKQNKYEQAEHFRKKSFKIHQKAIKK--KGNLYGFALLRRRAL---------QLE 1081
L +YQ+ +Y+ A + + +I ++ +G YG L +L Q +
Sbjct: 1003 LGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQ 1062
Query: 1082 ELTLGKDTPDNAR---TLNELGVLYYLQNNLETADQFLKRSLEMRERV 1126
L++ D A + + LG ++ N A +L+ L + E++
Sbjct: 1063 HLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQL 1110
Score = 36.2 bits (82), Expect = 0.22
Identities = 50/202 (24%), Positives = 79/202 (39%), Gaps = 26/202 (12%)
Query: 943 ADLYETLGRFLKDLGLLSQAIVPLQRSLEI----RETALDPDHPRVAQSLHQLASVYVQW 998
A Y LG LG QAI L+R L I ++ AL+ D + L VY Q
Sbjct: 957 AQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESD------AACGLGGVYQQM 1010
Query: 999 KKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQ 1058
++ A Q ++ L+I+E R L Y+ +E+A ++++ I
Sbjct: 1011 GEYDTALQYHQLDLQIAEETNNPT--CQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAA 1068
Query: 1059 KAIKKKGNLYGFALLRR--RALQ---------LEELTLGKDT---PDNARTLNELGVLYY 1104
+ ++ L R ALQ E L L + D A+ + LG+ +
Sbjct: 1069 QMNDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLW 1128
Query: 1105 LQNNLETADQFLKRSLEMRERV 1126
NLE A L R+ + E +
Sbjct: 1129 ASGNLEEAQHQLYRASALFETI 1150
>gi|87162455 hypothetical protein LOC23277 [Homo sapiens]
Length = 1309
Score = 69.7 bits (169), Expect = 2e-11
Identities = 60/245 (24%), Positives = 102/245 (41%), Gaps = 6/245 (2%)
Query: 1042 KYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGV 1101
K A HF + Q+ K+G L AL L G + L L
Sbjct: 974 KASDAFHFFQSGQAKVQQGFLKEG-----CELINEALNLFNNVYGAMHVETCACLRLLAR 1028
Query: 1102 LYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERA 1161
L+Y+ + A ++++ M ERV+G +HP+ Q +LA C Q A L RA
Sbjct: 1029 LHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRA 1088
Query: 1162 LDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATA 1221
+ DHP +A ++ ++ + + D ++ E A+ + K GPK VA +
Sbjct: 1089 RYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTKYHGPKALKVALS 1148
Query: 1222 LVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAA 1281
+A +Y + AL + IY+ LG H + E+ + L L+ + ++
Sbjct: 1149 HHLVARVYESKAEFRSALQHEKEGYTIYKTQLGEDHEKTKESSEYLKCLTQQAVALQRTM 1208
Query: 1282 -ELYK 1285
E+Y+
Sbjct: 1209 NEIYR 1213
Score = 35.8 bits (81), Expect = 0.28
Identities = 25/99 (25%), Positives = 41/99 (41%)
Query: 1189 KMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKI 1248
+ G L + L A+ + +G H L LA L+ M + EAL ++A+ +
Sbjct: 990 QQGFLKEGCELINEALNLFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLM 1049
Query: 1249 YEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRA 1287
E +G HP + +LA+ + A L RA
Sbjct: 1050 SERVMGTEHPNTIQEYMHLALYCFASSQLSTALSLLYRA 1088
>gi|18104962 amyloid beta precursor protein-binding protein 2 [Homo
sapiens]
Length = 585
Score = 69.3 bits (168), Expect = 2e-11
Identities = 63/251 (25%), Positives = 119/251 (47%), Gaps = 18/251 (7%)
Query: 950 GRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLA-SVYVQWK---KFGNAE 1005
G +L ++ + Q++ Q +L+IR++ + VA + LA S YV KF NA
Sbjct: 295 GFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNAL 354
Query: 1006 QLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKG 1065
++A+ I + DH A A + + E A K + Q+ +++
Sbjct: 355 FHAERAIGIITHILPEDHLLLASSKRVKALILE-----EIAIDCHNK--ETEQRLLQEAH 407
Query: 1066 NLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRER 1125
+L+ +LQL + G+ A+ LG LY + A++ ++++++E+
Sbjct: 408 DLH------LSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQ 461
Query: 1126 VLGPDHPDCAQSLNNLAALCN-EKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLA 1184
+LG + + A S+ +LA+L N + QY+ AE+LY R++ I ++ + L Y + L
Sbjct: 462 LLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLI 521
Query: 1185 ILYKKMGKLDK 1195
LY +G +K
Sbjct: 522 KLYNSIGNYEK 532
Score = 62.4 bits (150), Expect = 3e-09
Identities = 59/257 (22%), Positives = 115/257 (44%), Gaps = 18/257 (7%)
Query: 981 HPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALA-TLYQK 1039
HP+ + +L + + +Y+ AL+I ++ +G + + A E LA + Y
Sbjct: 284 HPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVH 343
Query: 1040 Q---NKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTL 1096
Q K++ A +++ I I + +L + R +AL LEE+ + + + L
Sbjct: 344 QYSSGKFDNALFHAERAIGIITH-ILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRL 402
Query: 1097 NELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEE 1156
L+ A SL++ ++ G + A+ NL L +++ +AEE
Sbjct: 403 ------------LQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEE 450
Query: 1157 LYERALDIRRRALAPDHPSLAYTVKHLAILYK-KMGKLDKAVPLYELAVEIRQKSFGPKH 1215
++ +A+ I+ + L + +A +V HLA LY M + + A LY ++ I +K FG +
Sbjct: 451 MHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGY 510
Query: 1216 PSVATALVNLAVLYSQM 1232
+ L LY+ +
Sbjct: 511 SGLEYDYRGLIKLYNSI 527
Score = 60.8 bits (146), Expect = 8e-09
Identities = 71/314 (22%), Positives = 137/314 (43%), Gaps = 34/314 (10%)
Query: 984 VAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHP-YTARELEALATLYQKQNK 1042
V L Q + V ++F AEQL K A+ ++ + +G+ HP Y+ L+ L N
Sbjct: 245 VVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNI 304
Query: 1043 YEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVL 1102
+ S I+Q A+ + +++G + T +D ++ V
Sbjct: 305 CQ--------SVAIYQAALDIRQSVFG-------GKNIHVATAHEDLAYSSY------VH 343
Query: 1103 YYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQS-------LNNLAALCN----EKKQY 1151
Y + A +R++ + +L DH A S L +A C+ E++
Sbjct: 344 QYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLL 403
Query: 1152 DKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSF 1211
+A +L+ +L + ++A + A +L LY+ M K +A ++ A++I+++
Sbjct: 404 QEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLL 463
Query: 1212 GPKHPSVATALVNLAVLYS-QMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVL 1270
G + VA ++ +LA LY+ M ++ A LY R++ I + G + + + L L
Sbjct: 464 GQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKL 523
Query: 1271 SYEGGDFEKAAELY 1284
G++EK E +
Sbjct: 524 YNSIGNYEKVFEYH 537
Score = 60.5 bits (145), Expect = 1e-08
Identities = 59/234 (25%), Positives = 110/234 (47%), Gaps = 16/234 (6%)
Query: 1073 LRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHP 1132
L + A+ L G P + TL + G +N+ + + +L++R+ V G +
Sbjct: 268 LIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNI 327
Query: 1133 DCAQSLNNLAALCNEKK----QYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYK 1188
A + +LA + ++D A ERA+ I L DH LA + + A++ +
Sbjct: 328 HVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILE 387
Query: 1189 KMG-----------KLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVE 1237
++ L +A L+ ++++ +K+FG + A NL LY M+K E
Sbjct: 388 EIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKE 447
Query: 1238 ALPLYERALKIYEDSLGRMHPRVGETLKNLAVL-SYEGGDFEKAAELYKRAMEI 1290
A ++ +A++I E LG+ V ++ +LA L +Y+ +E A +LY R++ I
Sbjct: 448 AEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAI 501
Score = 50.8 bits (120), Expect = 8e-06
Identities = 36/147 (24%), Positives = 70/147 (47%), Gaps = 2/147 (1%)
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLN 1139
+++L+ + A EL L + +++ + A ++ + M+E G L
Sbjct: 193 MDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEA--MKEITAGLPVKVVVDVLR 250
Query: 1140 NLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPL 1199
+ C K+++ KAE+L + A+ + R HP + T+ + + ++V +
Sbjct: 251 QASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAI 310
Query: 1200 YELAVEIRQKSFGPKHPSVATALVNLA 1226
Y+ A++IRQ FG K+ VATA +LA
Sbjct: 311 YQAALDIRQSVFGGKNIHVATAHEDLA 337
Score = 46.2 bits (108), Expect = 2e-04
Identities = 33/119 (27%), Positives = 56/119 (47%), Gaps = 2/119 (1%)
Query: 928 QYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQS 987
Q K GE N+ A Y LGR + + +A ++++I+E L + VA S
Sbjct: 415 QLAKKAFGEFNVQT-AKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALS 473
Query: 988 LHQLASVY-VQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQ 1045
+ LAS+Y ++ NAE+LY +++ I + +G + + L LY YE+
Sbjct: 474 VGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEK 532
Score = 37.7 bits (86), Expect = 0.074
Identities = 27/100 (27%), Positives = 46/100 (46%), Gaps = 4/100 (4%)
Query: 1195 KAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLG 1254
KA L + AV + + FG KHP + L++ + +++ +Y+ AL I + G
Sbjct: 264 KAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFG 323
Query: 1255 RMHPRVGETLKNLA----VLSYEGGDFEKAAELYKRAMEI 1290
+ V ++LA V Y G F+ A +RA+ I
Sbjct: 324 GKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGI 363
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 67.4 bits (163), Expect = 9e-11
Identities = 70/281 (24%), Positives = 123/281 (43%), Gaps = 48/281 (17%)
Query: 1024 PYTARELEALATLYQKQNKYEQAEHFRKKSFKI---HQKAIKKKGNLYGFA----LLRRR 1076
P+ A+ A + Q + ++A + + + K+ H A+ G L + +R
Sbjct: 372 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQR 431
Query: 1077 ALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQ 1136
ALQL P + R L LG L Q E A LK S++ P+ A
Sbjct: 432 ALQLH--------PQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYG--------PEFAD 475
Query: 1137 SLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKA 1196
+ ++LA+L E++++ +AEE+Y+ + PD L + + G +KA
Sbjct: 476 AYSSLASLLAEQERFKEAEEIYQTGI-----KNCPDSSDLH---NNYGVFLVDTGLPEKA 527
Query: 1197 VPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRM 1256
V Y+ A+++ PS A+VNL LY + ++ A Y+RAL++ +
Sbjct: 528 VAHYQQAIKL--------SPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKA---- 575
Query: 1257 HPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSL 1297
E L L L Y G +E+A ++Y+ A ++ ++ L
Sbjct: 576 -----EILSPLGALYYNTGRYEEALQIYQEAAALQPSQREL 611
Score = 57.4 bits (137), Expect = 9e-08
Identities = 73/318 (22%), Positives = 128/318 (40%), Gaps = 69/318 (21%)
Query: 935 GEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASV 994
G N +DL+ G FL D GL +A+ Q++++ L P H +L +L
Sbjct: 500 GIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIK-----LSPSHHVAMVNLGRL--- 551
Query: 995 YVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSF 1054
Y + AE+ YK+AL+++ + A L L LY +YE+A
Sbjct: 552 YRSLGENSMAEEWYKRALQVA---------HKAEILSPLGALYYNTGRYEEA-------L 595
Query: 1055 KIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQ 1114
+I+Q+A + + L + L + T + N E G
Sbjct: 596 QIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETG-------------- 641
Query: 1115 FLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHP 1174
C + L+A+ ++++ +DKA + ++AL ++ + P
Sbjct: 642 -------------------CLECYRLLSAIYSKQENHDKALDAIDKALQLKPKD--PKVI 680
Query: 1175 SLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKK 1234
S + K + ++ LDKA Y +AV++ +P A A +N+ + K
Sbjct: 681 SELFFTKGNQL--REQNLLDKAFESYRVAVQL--------NPDQAQAWMNMGGIQHIKGK 730
Query: 1235 HVEALPLYERALKIYEDS 1252
+V A YERAL++ DS
Sbjct: 731 YVSARAYYERALQLVPDS 748
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 67.0 bits (162), Expect = 1e-10
Identities = 81/349 (23%), Positives = 138/349 (39%), Gaps = 80/349 (22%)
Query: 942 LADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKF 1001
LA+ Y LG K+ G L +AI + +L ++ +D LA+ V
Sbjct: 78 LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFID--------GYINLAAALVAAGDM 129
Query: 1002 GNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAI 1061
A Q Y AL+ + + Y L L + + E+A+ + KAI
Sbjct: 130 EGAVQAYVSALQYNPDLYCVRSD--------LGNLLKALGRLEEAK-------ACYLKAI 174
Query: 1062 KKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLE 1121
+ + P+ A + LG ++ Q + A ++++
Sbjct: 175 ETQ-------------------------PNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVT 209
Query: 1122 MRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVK 1181
+ P+ + NL + E + +D+A Y RAL +L+P+H A
Sbjct: 210 L--------DPNFLDAYINLGNVLKEARIFDRAVAAYLRAL-----SLSPNH---AVVHG 253
Query: 1182 HLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPL 1241
+LA +Y + G +D A+ Y A+E++ P A NLA + EA
Sbjct: 254 NLACVYYEQGLIDLAIDTYRRAIELQ--------PHFPDAYCNLANALKEKGSVAEAEDC 305
Query: 1242 YERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEI 1290
Y AL R+ P ++L NLA + E G+ E+A LY++A+E+
Sbjct: 306 YNTAL--------RLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEV 346
Score = 53.9 bits (128), Expect = 1e-06
Identities = 71/308 (23%), Positives = 124/308 (40%), Gaps = 72/308 (23%)
Query: 944 DLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGN 1003
D Y LG LK+ + +A+ R+L +L P+H V +L A VY +
Sbjct: 216 DAYINLGNVLKEARIFDRAVAAYLRAL-----SLSPNHAVVHGNL---ACVYYEQGLIDL 267
Query: 1004 AEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKK 1063
A Y++A+E+ HF + A+K+
Sbjct: 268 AIDTYRRAIELQP-------------------------------HFPDAYCNL-ANALKE 295
Query: 1064 KGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMR 1123
KG++ AL+L P +A +LN L + Q N+E A + +++LE+
Sbjct: 296 KGSVAEAEDCYNTALRL--------CPTHADSLNNLANIKREQGNIEEAVRLYRKALEV- 346
Query: 1124 ERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHL 1183
P+ A + +NLA++ ++ + +A Y+ A+ I P+ A ++
Sbjct: 347 -------FPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRIS--------PTFADAYSNM 391
Query: 1184 AILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYE 1243
K+M + A+ Y A++I +P+ A A NLA ++ EA+ Y
Sbjct: 392 GNTLKEMQDVQGALQCYTRAIQI--------NPAFADAHSNLASIHKDSGNIPEAIASYR 443
Query: 1244 RALKIYED 1251
ALK+ D
Sbjct: 444 TALKLKPD 451
Score = 42.7 bits (99), Expect = 0.002
Identities = 53/232 (22%), Positives = 91/232 (39%), Gaps = 52/232 (22%)
Query: 1087 KDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCN 1146
K P A + LG +Y + L+ A + + +L ++ PD NLAA
Sbjct: 73 KQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLK--------PDFIDGYINLAAALV 124
Query: 1147 EKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEI 1206
+ A + Y AL +P L L L K +G+L++A Y A+E
Sbjct: 125 AAGDMEGAVQAYVSALQY--------NPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET 176
Query: 1207 RQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK- 1265
+ P+ A A NL +++ + A+ +E+A+ + + L + +G LK
Sbjct: 177 Q--------PNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDA-YINLGNVLKE 227
Query: 1266 --------------------------NLAVLSYEGGDFEKAAELYKRAMEIK 1291
NLA + YE G + A + Y+RA+E++
Sbjct: 228 ARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 279
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 67.0 bits (162), Expect = 1e-10
Identities = 81/349 (23%), Positives = 138/349 (39%), Gaps = 80/349 (22%)
Query: 942 LADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKF 1001
LA+ Y LG K+ G L +AI + +L ++ +D LA+ V
Sbjct: 88 LAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFID--------GYINLAAALVAAGDM 139
Query: 1002 GNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAI 1061
A Q Y AL+ + + Y L L + + E+A+ + KAI
Sbjct: 140 EGAVQAYVSALQYNPDLYCVRSD--------LGNLLKALGRLEEAK-------ACYLKAI 184
Query: 1062 KKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLE 1121
+ + P+ A + LG ++ Q + A ++++
Sbjct: 185 ETQ-------------------------PNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVT 219
Query: 1122 MRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVK 1181
+ P+ + NL + E + +D+A Y RAL +L+P+H A
Sbjct: 220 L--------DPNFLDAYINLGNVLKEARIFDRAVAAYLRAL-----SLSPNH---AVVHG 263
Query: 1182 HLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPL 1241
+LA +Y + G +D A+ Y A+E++ P A NLA + EA
Sbjct: 264 NLACVYYEQGLIDLAIDTYRRAIELQ--------PHFPDAYCNLANALKEKGSVAEAEDC 315
Query: 1242 YERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEI 1290
Y AL R+ P ++L NLA + E G+ E+A LY++A+E+
Sbjct: 316 YNTAL--------RLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEV 356
Score = 53.9 bits (128), Expect = 1e-06
Identities = 71/308 (23%), Positives = 124/308 (40%), Gaps = 72/308 (23%)
Query: 944 DLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGN 1003
D Y LG LK+ + +A+ R+L +L P+H V +L A VY +
Sbjct: 226 DAYINLGNVLKEARIFDRAVAAYLRAL-----SLSPNHAVVHGNL---ACVYYEQGLIDL 277
Query: 1004 AEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKK 1063
A Y++A+E+ HF + A+K+
Sbjct: 278 AIDTYRRAIELQP-------------------------------HFPDAYCNL-ANALKE 305
Query: 1064 KGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMR 1123
KG++ AL+L P +A +LN L + Q N+E A + +++LE+
Sbjct: 306 KGSVAEAEDCYNTALRL--------CPTHADSLNNLANIKREQGNIEEAVRLYRKALEV- 356
Query: 1124 ERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHL 1183
P+ A + +NLA++ ++ + +A Y+ A+ I P+ A ++
Sbjct: 357 -------FPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRIS--------PTFADAYSNM 401
Query: 1184 AILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYE 1243
K+M + A+ Y A++I +P+ A A NLA ++ EA+ Y
Sbjct: 402 GNTLKEMQDVQGALQCYTRAIQI--------NPAFADAHSNLASIHKDSGNIPEAIASYR 453
Query: 1244 RALKIYED 1251
ALK+ D
Sbjct: 454 TALKLKPD 461
Score = 42.7 bits (99), Expect = 0.002
Identities = 53/232 (22%), Positives = 91/232 (39%), Gaps = 52/232 (22%)
Query: 1087 KDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCN 1146
K P A + LG +Y + L+ A + + +L ++ PD NLAA
Sbjct: 83 KQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLK--------PDFIDGYINLAAALV 134
Query: 1147 EKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEI 1206
+ A + Y AL +P L L L K +G+L++A Y A+E
Sbjct: 135 AAGDMEGAVQAYVSALQY--------NPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET 186
Query: 1207 RQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLK- 1265
+ P+ A A NL +++ + A+ +E+A+ + + L + +G LK
Sbjct: 187 Q--------PNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDA-YINLGNVLKE 237
Query: 1266 --------------------------NLAVLSYEGGDFEKAAELYKRAMEIK 1291
NLA + YE G + A + Y+RA+E++
Sbjct: 238 ARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQ 289
>gi|19923891 kinesin-like 8 isoform c [Homo sapiens]
Length = 315
Score = 66.6 bits (161), Expect = 1e-10
Identities = 36/92 (39%), Positives = 49/92 (53%)
Query: 1086 GKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALC 1145
G + P RTL+ L + Y Q E A K++LE ER G HPD A LN LA +
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 263
Query: 1146 NEKKQYDKAEELYERALDIRRRALAPDHPSLA 1177
++ +Y +A L AL IR L PDHP+++
Sbjct: 264 RDQNKYKEAAHLLNDALSIRESTLGPDHPAVS 295
Score = 60.5 bits (145), Expect = 1e-08
Identities = 35/87 (40%), Positives = 49/87 (56%)
Query: 1174 PSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMK 1233
P+ T+ +L I Y G+ + AVPL + A+E +++ G HP VAT L LA++Y
Sbjct: 208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQN 267
Query: 1234 KHVEALPLYERALKIYEDSLGRMHPRV 1260
K+ EA L AL I E +LG HP V
Sbjct: 268 KYKEAAHLLNDALSIRESTLGPDHPAV 294
Score = 50.8 bits (120), Expect = 8e-06
Identities = 28/80 (35%), Positives = 39/80 (48%)
Query: 982 PRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQN 1041
P ++LH L Y ++ A L KQALE E G HP A L LA +Y+ QN
Sbjct: 208 PARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQN 267
Query: 1042 KYEQAEHFRKKSFKIHQKAI 1061
KY++A H + I + +
Sbjct: 268 KYKEAAHLLNDALSIRESTL 287
Score = 50.1 bits (118), Expect = 1e-05
Identities = 28/92 (30%), Positives = 49/92 (53%)
Query: 1128 GPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILY 1187
G + P ++L+NL + +Y+ A L ++AL+ R HP +A + LA++Y
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 263
Query: 1188 KKMGKLDKAVPLYELAVEIRQKSFGPKHPSVA 1219
+ K +A L A+ IR+ + GP HP+V+
Sbjct: 264 RDQNKYKEAAHLLNDALSIRESTLGPDHPAVS 295
Score = 47.8 bits (112), Expect = 7e-05
Identities = 36/113 (31%), Positives = 47/113 (41%), Gaps = 24/113 (21%)
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQ 1079
G + P R L L Y Q +YE A L ++AL+
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVA------------------------VPLCKQALE 239
Query: 1080 LEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHP 1132
E T G+ PD A LN L ++Y QN + A L +L +RE LGPDHP
Sbjct: 240 DLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHP 292
Score = 45.4 bits (106), Expect = 4e-04
Identities = 30/93 (32%), Positives = 50/93 (53%), Gaps = 3/93 (3%)
Query: 1212 GPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLS 1271
G + P+ L NL + Y+ ++ A+PL ++AL+ E + GR HP V L LA++
Sbjct: 204 GYEIPARLRTLHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVY 263
Query: 1272 YEGGDFEKAAELYKRAMEIKEAETSLLGGKAPS 1304
+ +++AA L A+ I+E S LG P+
Sbjct: 264 RDQNKYKEAAHLLNDALSIRE---STLGPDHPA 293
Score = 41.6 bits (96), Expect = 0.005
Identities = 26/65 (40%), Positives = 33/65 (50%), Gaps = 1/65 (1%)
Query: 961 QAIVPL-QRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
+ VPL +++LE E HP VA L+ LA VY K+ A L AL I E+
Sbjct: 228 EVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTL 287
Query: 1020 GADHP 1024
G DHP
Sbjct: 288 GPDHP 292
>gi|24308163 fem-1 homolog a [Homo sapiens]
Length = 669
Score = 56.2 bits (134), Expect = 2e-07
Identities = 44/160 (27%), Positives = 78/160 (48%), Gaps = 13/160 (8%)
Query: 1074 RRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQ---FLKRSLEMRERVLGPD 1130
R A++ EL LG D R L LG L + + +E Q +L + E + VL D
Sbjct: 294 REAAVEALEL-LGATYVDKKRDL--LGALKHWRRAMELRHQGGEYLPKP-EPPQLVLAYD 349
Query: 1131 HPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKM 1190
+ + L AL + +E+ +AL IR R L P HP +Y +++ +Y
Sbjct: 350 YSREVNTTEELEALITDP------DEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADS 403
Query: 1191 GKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYS 1230
G ++ + L++ A++++Q + P P A++ ++ A L+S
Sbjct: 404 GNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFS 443
Score = 38.9 bits (89), Expect = 0.033
Identities = 37/152 (24%), Positives = 65/152 (42%), Gaps = 21/152 (13%)
Query: 968 RSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTA 1027
++L IRE L P HP + + +VY F +L+K AL++ ++ P TA
Sbjct: 373 QALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTA 432
Query: 1028 RELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIK-KKGNLYGFA----LLRRRALQLEE 1082
+ A L+ S+ + +A K G GFA +L + ++E
Sbjct: 433 SSFLSFAELF---------------SYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVER 477
Query: 1083 -LTLGKDTPDNARTLNELGVLYYLQNNLETAD 1113
L L ++ D+A+ L ++ +L LE +
Sbjct: 478 ALQLPREPGDSAQFTKALAIILHLLYLLEKVE 509
Score = 35.4 bits (80), Expect = 0.37
Identities = 22/72 (30%), Positives = 34/72 (47%)
Query: 1073 LRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHP 1132
+R +AL + E LG PD + + G +Y N E + K +L+M++ L P P
Sbjct: 370 MRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSP 429
Query: 1133 DCAQSLNNLAAL 1144
A S + A L
Sbjct: 430 MTASSFLSFAEL 441
Score = 33.9 bits (76), Expect = 1.1
Identities = 45/189 (23%), Positives = 70/189 (37%), Gaps = 17/189 (8%)
Query: 1134 CAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKL 1193
CAQ A C+ + E YE R A L T K L
Sbjct: 264 CAQPQG--APCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATY------VDKKRDL 315
Query: 1194 DKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALP--------LYERA 1245
A+ + A+E+R + G P + LA YS+ E L + +A
Sbjct: 316 LGALKHWRRAMELRHQG-GEYLPKPEPPQLVLAYDYSREVNTTEELEALITDPDEMRMQA 374
Query: 1246 LKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAPSR 1305
L I E LG HP ++ + + G+FE+ L+K A++++++ L S
Sbjct: 375 LLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASS 434
Query: 1306 HSSSGDTFS 1314
S + FS
Sbjct: 435 FLSFAELFS 443
>gi|17864094 feminization 1 homolog a [Homo sapiens]
Length = 617
Score = 53.9 bits (128), Expect = 1e-06
Identities = 24/78 (30%), Positives = 46/78 (58%)
Query: 1155 EELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPK 1214
+E+ +AL IR R L P HP +Y +++ +Y G + + L++ A++++Q + P
Sbjct: 316 DEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPL 375
Query: 1215 HPSVATALVNLAVLYSQM 1232
P A++L++ A L+S M
Sbjct: 376 SPMTASSLLSFAELFSFM 393
Score = 44.3 bits (103), Expect = 8e-04
Identities = 24/86 (27%), Positives = 45/86 (52%)
Query: 1105 LQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDI 1164
L+ + D+ ++L +RER+LGP HPD + + A+ + + + L++ ALD+
Sbjct: 308 LEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDM 367
Query: 1165 RRRALAPDHPSLAYTVKHLAILYKKM 1190
++ L P P A ++ A L+ M
Sbjct: 368 QQSNLDPLSPMTASSLLSFAELFSFM 393
Score = 37.7 bits (86), Expect = 0.074
Identities = 23/81 (28%), Positives = 37/81 (45%)
Query: 957 GLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISE 1016
GL++ ++L IRE L P HP + + +VY F L+K AL++ +
Sbjct: 310 GLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQ 369
Query: 1017 NAYGADHPYTARELEALATLY 1037
+ P TA L + A L+
Sbjct: 370 SNLDPLSPMTASSLLSFAELF 390
Score = 35.8 bits (81), Expect = 0.28
Identities = 26/85 (30%), Positives = 41/85 (48%), Gaps = 1/85 (1%)
Query: 1073 LRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHP 1132
+R +AL + E LG PD + + G +Y N + K +L+M++ L P P
Sbjct: 318 MRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSP 377
Query: 1133 DCAQSLNNLAALCNEKKQYDKAEEL 1157
A SL + A L + Q D+A+ L
Sbjct: 378 MTASSLLSFAELFSFMLQ-DRAKGL 401
Score = 31.2 bits (69), Expect = 6.9
Identities = 18/71 (25%), Positives = 34/71 (47%)
Query: 1244 RALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLLGGKAP 1303
+AL I E LG HP ++ + + G+F++ L+K A++++++ L
Sbjct: 321 QALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTA 380
Query: 1304 SRHSSSGDTFS 1314
S S + FS
Sbjct: 381 SSLLSFAELFS 391
Score = 31.2 bits (69), Expect = 6.9
Identities = 16/68 (23%), Positives = 32/68 (47%)
Query: 1203 AVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGE 1262
A+ IR++ GP HP + + +Y+ + L++ AL + + +L + P
Sbjct: 322 ALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTAS 381
Query: 1263 TLKNLAVL 1270
+L + A L
Sbjct: 382 SLLSFAEL 389
>gi|22547159 tetratricopeptide repeat domain 19 [Homo sapiens]
Length = 501
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/262 (22%), Positives = 105/262 (40%), Gaps = 39/262 (14%)
Query: 1034 ATLYQKQNKYEQAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRAL---------QLEELT 1084
A L +++ E+AE + ++ + KK Y + L+ A QL + T
Sbjct: 224 AKLSIMKDEPEEAELILHDALRLAYQTDNKKAITYTYDLMANLAFIRGQLENAEQLFKAT 283
Query: 1085 L------GKDTPDNA--RTLNELGVLYYLQNNLE-----------TADQFLKRSLEMRER 1125
+ G DNA +L +Y QN E T ++ ++R E+ E
Sbjct: 284 MSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAED 343
Query: 1126 VLGPD-----HPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAYTV 1180
++ + H L+ A KQ +A+ +YE+AL I HP +
Sbjct: 344 IMSVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLM 403
Query: 1181 KHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALP 1240
LA G+ D+A + A ++ ++ HP + L NLA + +++ +A
Sbjct: 404 SDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPELHMVLSNLAAVLMHRERYTQAKE 460
Query: 1241 LYERAL---KIYEDSLGRMHPR 1259
+Y+ AL K+ +D + H R
Sbjct: 461 IYQEALKQAKLKKDEISVQHIR 482
Score = 41.6 bits (96), Expect = 0.005
Identities = 46/209 (22%), Positives = 88/209 (42%), Gaps = 22/209 (10%)
Query: 1003 NAEQLYKQALEISENAYGADHPYTARELEA-LATLYQKQNKYEQAEHFRKKSFKIHQKAI 1061
NAEQL+K + E+ LA++Y QN+ E A + ++ I
Sbjct: 275 NAEQLFKATMSYLLGGGMKQEDNAIIEISLKLASIYAAQNRQEFAVAGYEFCISTLEEKI 334
Query: 1062 KKKGNLYGFALLRRRALQLEE-----LTLGKDTPDNARTLNELGVLYYLQNNLETADQFL 1116
+++ L + +EE L LG AR L A +
Sbjct: 335 EREKEL------AEDIMSVEEKANTHLLLGMCLDACARYL-------LFSKQPSQAQRMY 381
Query: 1117 KRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSL 1176
+++L++ E + G HP +++LA + + ++D+A +RA D+ R+ +HP L
Sbjct: 382 EKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQI---NHPEL 438
Query: 1177 AYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
+ +LA + + +A +Y+ A++
Sbjct: 439 HMVLSNLAAVLMHRERYTQAKEIYQEALK 467
Score = 40.4 bits (93), Expect = 0.011
Identities = 30/128 (23%), Positives = 58/128 (45%), Gaps = 10/128 (7%)
Query: 966 LQRSLEIRETALDPD-----HPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYG 1020
++R E+ E + + H + L A + K+ A+++Y++AL+ISE G
Sbjct: 334 IEREKELAEDIMSVEEKANTHLLLGMCLDACARYLLFSKQPSQAQRMYEKALQISEEIQG 393
Query: 1021 ADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKI-----HQKAIKKKGNLYGFALLRR 1075
HP T + LAT Q ++++A + +++ + H + NL + R
Sbjct: 394 ERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDLARQINHPELHMVLSNLAAVLMHRE 453
Query: 1076 RALQLEEL 1083
R Q +E+
Sbjct: 454 RYTQAKEI 461
Score = 34.3 bits (77), Expect = 0.82
Identities = 22/97 (22%), Positives = 48/97 (49%), Gaps = 4/97 (4%)
Query: 917 AMATEYFDSLKQYEKNCEGEDNMSCLADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETA 976
+ A ++ Q + +GE + + L L L G +A + +QR+ ++ A
Sbjct: 375 SQAQRMYEKALQISEEIQGERHPQTIV-LMSDLATTLDAQGRFDEAYIYMQRASDL---A 430
Query: 977 LDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALE 1013
+HP + L LA+V + +++ A+++Y++AL+
Sbjct: 431 RQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALK 467
Score = 32.7 bits (73), Expect = 2.4
Identities = 18/58 (31%), Positives = 32/58 (55%)
Query: 1233 KKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKRAMEI 1290
K+ +A +YE+AL+I E+ G HP+ + +LA G F++A +RA ++
Sbjct: 372 KQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYIYMQRASDL 429
Score = 31.6 bits (70), Expect = 5.3
Identities = 28/104 (26%), Positives = 47/104 (45%), Gaps = 5/104 (4%)
Query: 960 SQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFGNAEQLYKQALEISENAY 1019
SQA +++L+I E HP+ + LA+ +F A +Y Q S+ A
Sbjct: 375 SQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEA-YIYMQ--RASDLAR 431
Query: 1020 GADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQKAIKK 1063
+HP L LA + + +Y QA+ +++ K Q +KK
Sbjct: 432 QINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALK--QAKLKK 473
>gi|118766328 transmembrane and tetratricopeptide repeat containing 4
isoform 2 [Homo sapiens]
Length = 741
Score = 48.1 bits (113), Expect = 5e-05
Identities = 45/209 (21%), Positives = 88/209 (42%), Gaps = 32/209 (15%)
Query: 1090 PDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKK 1149
P NA+ +G + N A ++ + ++ + +P ++NNL + E+
Sbjct: 479 PLNAKVHYNIGKNLADKGNQTAAIRYYREAVRL--------NPKYVHAMNNLGNILKERN 530
Query: 1150 QYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQK 1209
+ +AEEL A+ I+ P A +L I+ + + + A Y A++ R+K
Sbjct: 531 ELQEAEELLSLAVQIQ--------PDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRK 582
Query: 1210 SFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAV 1269
+P NL LY+ + +HV+AL + A + P N+ +
Sbjct: 583 -----YPD---CYYNLGRLYADLNRHVDALNAWRNATV--------LKPEHSLAWNNMII 626
Query: 1270 LSYEGGDFEKAAELYKRAMEIKEAETSLL 1298
L G+ +A + + A+E+ + SL+
Sbjct: 627 LLDNTGNLAQAEAVGREALELIPNDHSLM 655
Score = 45.8 bits (107), Expect = 3e-04
Identities = 59/276 (21%), Positives = 119/276 (43%), Gaps = 38/276 (13%)
Query: 943 ADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFG 1002
A ++ +G+ L D G + AI + ++ + +P+ +++ L ++ + +
Sbjct: 482 AKVHYNIGKNLADKGNQTAAIRYYREAVRL--------NPKYVHAMNNLGNILKERNELQ 533
Query: 1003 NAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQK--- 1059
AE+L A++I P A L + ++E AE + + K +K
Sbjct: 534 EAEELLSLAVQIQ--------PDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPD 585
Query: 1060 AIKKKGNLYGFALLRRRALQL-EELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKR 1118
G LY AL T+ K P+++ N + +L NL A+ +
Sbjct: 586 CYYNLGRLYADLNRHVDALNAWRNATVLK--PEHSLAWNNMIILLDNTGNLAQAEAVGRE 643
Query: 1119 SLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAY 1178
+LE+ + DH + +LA + + ++Y ++E L+ +A+ +P+ A
Sbjct: 644 ALEL----IPNDH----SLMFSLANVLGKSQKYKESEALFLKAIKA--------NPNAAS 687
Query: 1179 TVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPK 1214
+LA+LY + G LD A YE+++++ + G K
Sbjct: 688 YHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTK 723
>gi|118766330 transmembrane and tetratricopeptide repeat containing 4
isoform 1 [Homo sapiens]
Length = 760
Score = 48.1 bits (113), Expect = 5e-05
Identities = 45/209 (21%), Positives = 88/209 (42%), Gaps = 32/209 (15%)
Query: 1090 PDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKK 1149
P NA+ +G + N A ++ + ++ + +P ++NNL + E+
Sbjct: 498 PLNAKVHYNIGKNLADKGNQTAAIRYYREAVRL--------NPKYVHAMNNLGNILKERN 549
Query: 1150 QYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQK 1209
+ +AEEL A+ I+ P A +L I+ + + + A Y A++ R+K
Sbjct: 550 ELQEAEELLSLAVQIQ--------PDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRK 601
Query: 1210 SFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAV 1269
+P NL LY+ + +HV+AL + A + P N+ +
Sbjct: 602 -----YPD---CYYNLGRLYADLNRHVDALNAWRNATV--------LKPEHSLAWNNMII 645
Query: 1270 LSYEGGDFEKAAELYKRAMEIKEAETSLL 1298
L G+ +A + + A+E+ + SL+
Sbjct: 646 LLDNTGNLAQAEAVGREALELIPNDHSLM 674
Score = 45.8 bits (107), Expect = 3e-04
Identities = 59/276 (21%), Positives = 119/276 (43%), Gaps = 38/276 (13%)
Query: 943 ADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFG 1002
A ++ +G+ L D G + AI + ++ + +P+ +++ L ++ + +
Sbjct: 501 AKVHYNIGKNLADKGNQTAAIRYYREAVRL--------NPKYVHAMNNLGNILKERNELQ 552
Query: 1003 NAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQK--- 1059
AE+L A++I P A L + ++E AE + + K +K
Sbjct: 553 EAEELLSLAVQIQ--------PDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPD 604
Query: 1060 AIKKKGNLYGFALLRRRALQL-EELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKR 1118
G LY AL T+ K P+++ N + +L NL A+ +
Sbjct: 605 CYYNLGRLYADLNRHVDALNAWRNATVLK--PEHSLAWNNMIILLDNTGNLAQAEAVGRE 662
Query: 1119 SLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAY 1178
+LE+ + DH + +LA + + ++Y ++E L+ +A+ +P+ A
Sbjct: 663 ALEL----IPNDH----SLMFSLANVLGKSQKYKESEALFLKAIKA--------NPNAAS 706
Query: 1179 TVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPK 1214
+LA+LY + G LD A YE+++++ + G K
Sbjct: 707 YHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTK 742
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 47.0 bits (110), Expect = 1e-04
Identities = 69/334 (20%), Positives = 138/334 (41%), Gaps = 56/334 (16%)
Query: 988 LHQLASVYVQWKKFGNAEQLYKQALEISE-NAYGADHPYTARELEA---LATLYQKQNKY 1043
L+ + +++ + G A++ + +L+ ++ A +H Y A + LA LY+ ++
Sbjct: 454 LNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEF 513
Query: 1044 EQAEHFRKKSFKIHQKAI----------KKKGNLYGFALLRRRALQLEELTLGKDTPDNA 1093
+AE K + H + + KGN Y + + ALQ+ + D PD
Sbjct: 514 HEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQ-----DHPD-- 566
Query: 1094 RTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCN------- 1146
+ L NL A Q + ER+L P ++ AL N
Sbjct: 567 --------AWSLIGNLHLAKQEWGPGQKKFERIL--KQPSTQSDTYSMLALGNVWLQTLH 616
Query: 1147 -EKKQYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVE 1205
+ +K + +RAL I ++ L D +L Y + + G +A ++ +
Sbjct: 617 QPTRDREKEKRHQDRALAIYKQVLRNDAKNL-YAANGIGAVLAHKGYFREARDVF---AQ 672
Query: 1206 IRQKSFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERAL-KIYEDSLGRMHPRVGETL 1264
+R+ + ++ +NLA +Y + K+++ A+ +YE L K Y+ H E +
Sbjct: 673 VREAT-----ADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYK------HQNT-EVV 720
Query: 1265 KNLAVLSYEGGDFEKAAELYKRAMEIKEAETSLL 1298
LA ++ G ++ + +A + ++T L+
Sbjct: 721 LYLARALFKCGKLQECKQTLLKARHVAPSDTVLM 754
Score = 43.1 bits (100), Expect = 0.002
Identities = 73/313 (23%), Positives = 121/313 (38%), Gaps = 61/313 (19%)
Query: 985 AQSLHQLASVYVQWKKFGNAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYE 1044
A+S +QLA + + ++ Y QA + Y
Sbjct: 306 AESCYQLARSF-------HVQEDYDQAFQY----------------------------YY 330
Query: 1045 QAEHFRKKSFKIHQKAIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYY 1104
QA F SF + + G +Y + + A Q E L K P+N T+ LG LY
Sbjct: 331 QATQFASSSFVLPFFGL---GQMYIYRGDKENASQCFEKVL-KAYPNNYETMKILGSLYA 386
Query: 1105 LQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDI 1164
+ E D ++ E+ +PD ++ LA + E+ A Y A I
Sbjct: 387 ASEDQEKRDIAKGHLKKVTEQ-----YPDDVEAWIELAQIL-EQTDIQGALSAYGTATRI 440
Query: 1165 RRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATAL-- 1222
+ + D P + ++ L+ ++G L +A Y LA R K+ A+
Sbjct: 441 LQEKVQADVP--PEILNNVGALHFRLGNLGEA-KKYFLASLDRAKAEAEHDEHYYNAISV 497
Query: 1223 ---VNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEK 1279
NLA LY M + EA LY+ L R HP + L ++ + G+F +
Sbjct: 498 TTSYNLARLYEAMCEFHEAEKLYKNIL--------REHPNYVDCYLRLGAMARDKGNFYE 549
Query: 1280 AAELYKRAMEIKE 1292
A++ +K A++I +
Sbjct: 550 ASDWFKEALQINQ 562
>gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens]
Length = 1316
Score = 45.4 bits (106), Expect = 4e-04
Identities = 63/256 (24%), Positives = 112/256 (43%), Gaps = 26/256 (10%)
Query: 1009 KQALEISENAYGADHPYTARELEALATLYQKQNKYEQA--EHFRKKSFKI-HQKAIKKKG 1065
++AL I +N A+ PY E +A +Y K K + FR+ + ++ + ++ G
Sbjct: 671 ERALSILQNVT-AEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLLLG 729
Query: 1066 NLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKRSLEMRER 1125
+ Y L A+ E L ++ P + +++G +N A + + +L+ ++
Sbjct: 730 DAYMNILEPEEAIVAYEQALNQN-PKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQK 788
Query: 1126 VLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRR----RALAPDHPSLAYTVK 1181
+LA L + K YDKAE++ + AL AL D
Sbjct: 789 ---------NYLCYDLAELLLKLKWYDKAEKVLQHALAHEPVNELSALMEDGRCQVL--- 836
Query: 1182 HLAILYKKMGKLDKAVPLYELAVEIRQ---KSFGPKHPSVATALVNLAV-LYSQMKKHVE 1237
LA +Y KM KL A+ + A E++ K + P A +LA + +++ KH
Sbjct: 837 -LAKVYSKMEKLGDAITALQQARELQARVLKRVQMEQPDAVPAQKHLAAEICAEIAKHSV 895
Query: 1238 ALPLYERALKIYEDSL 1253
A YE+A+K Y ++L
Sbjct: 896 AQRDYEKAIKFYREAL 911
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 45.1 bits (105), Expect = 5e-04
Identities = 38/146 (26%), Positives = 65/146 (44%), Gaps = 17/146 (11%)
Query: 83 ELEYAAAEYERLRKEYEIFRVSKNQELLSMGRREAKLDTENKRLRAELQALQKTYQKILR 142
+L+ A E E ++++ F SK Q++L +L+ EN RLRAE+ T ++ +
Sbjct: 1663 QLQEAEQEMEEMKEKMRKFAKSKQQKIL-------ELEEENDRLRAEVHPAGDTAKECME 1715
Query: 143 EKESALEAKYQAMERAATFEHDRDKVKRQFKIFRETKENEIQDLLRAKRELESKLQRLQA 202
S+ + + +ER K + +++ E+QDL SK L+A
Sbjct: 1716 TLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEA 1775
Query: 203 QGIQVFDPGESDSDDNCTDVTAAGTQ 228
++ DN T+VT GTQ
Sbjct: 1776 ----------TEKHDNQTNVTEEGTQ 1791
Score = 34.3 bits (77), Expect = 0.82
Identities = 45/179 (25%), Positives = 80/179 (44%), Gaps = 41/179 (22%)
Query: 70 LGASFKSTGSSVPELE----YAAAEYERLRKEYEI----FRVSKNQELLSMGRREAKLDT 121
L A +S G S+ L+ +A E + L+++Y+ K Q LL+ R +T
Sbjct: 2729 LTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSET 2788
Query: 122 E---NKRLRAELQALQKTYQKILREKE------SALEAKY---QAMERA-ATFEHDRDKV 168
N L L+K Q++L + E S LE Y Q+ +A A+ +++RD +
Sbjct: 2789 AFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL 2848
Query: 169 KRQFKIFRETKEN-------------EIQDLLRAKRELES-------KLQRLQAQGIQV 207
+ + FR+++E E+Q L +A L++ +L+ LQ Q +Q+
Sbjct: 2849 WNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQI 2907
Score = 31.6 bits (70), Expect = 5.3
Identities = 35/167 (20%), Positives = 69/167 (41%), Gaps = 32/167 (19%)
Query: 70 LGASFKSTGSSVPELEYAAAEYERLRKEYEIFRVSKNQ--------------ELLSMGRR 115
L + KS S + + +Y++L + + + K+Q E+ +
Sbjct: 2459 LDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518
Query: 116 EAKLDTENKRLRAEL--------------QALQKTYQKILREKESALEAKYQAM-ERAAT 160
L++EN +L AEL + QK ++ ++ LE KY + E+
Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
Query: 161 FEHDRDKVKRQFKIFRETKEN---EIQDLLRAKRELESKLQRLQAQG 204
E + ++R F +E K++ EI+ L + +L ++ LQ +G
Sbjct: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEG 2625
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 44.3 bits (103), Expect = 8e-04
Identities = 46/168 (27%), Positives = 75/168 (44%), Gaps = 23/168 (13%)
Query: 48 GAGAAAGAGPG-------SLPRGVGAGGLLGASFKSTGSSVPELEYAAAEYERLRK---E 97
G A GPG SLPR AG G + V EL+ E E LR+ +
Sbjct: 940 GGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELK-DRLELELLRQGEEQ 998
Query: 98 YEIFRVSKNQELLSMGRREAKLDTENKRLRAELQALQKTYQKILREKESALEAK----YQ 153
YE K Q + + +L E + AEL+AL++T + +E + LE K Q
Sbjct: 999 YECVLKRKEQHVAEQISKMMELAREKQA--AELKALKETSENDTKEMKKKLETKRLERIQ 1056
Query: 154 AMERAATFEHDRDKVKRQFKIFRETKENEIQDLLRAKRELESKLQRLQ 201
M + T + ++++KR E + IQ++++ +++ L+R Q
Sbjct: 1057 GMTKVTTDKMAQERLKR------EINNSHIQEVVQVIKQMTENLERHQ 1098
Score = 35.0 bits (79), Expect = 0.48
Identities = 45/165 (27%), Positives = 70/165 (42%), Gaps = 26/165 (15%)
Query: 38 ARLLRNSFRRGAGAAAGAGPGSLPRGVGAGGLLGASFKSTGSSVPELEYAAAEYERLRKE 97
AR +RGA A GP + GVGA L S+P E A A
Sbjct: 917 ARRWEELLQRGAAQLAELGPPGVG-GVGACKLGPGKGSRKKRSLPREESAGAA------- 968
Query: 98 YEIFRVSKNQELLSMGRREAKLDTENKRLRAELQALQKTYQKILREKESALEAKYQAMER 157
+ E + RE K E + LR ++ Y+ +L+ KE + + M
Sbjct: 969 -----PGEGPEGVDGRVRELKDRLELELLRQG----EEQYECVLKRKEQHVAEQISKMME 1019
Query: 158 AATFEHDRDKVKRQFKIFRETKENEIQDLLRAKRELESK-LQRLQ 201
A R+K + K +ET EN+ +++ K++LE+K L+R+Q
Sbjct: 1020 LA-----REKQAAELKALKETSENDTKEM---KKKLETKRLERIQ 1056
>gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo
sapiens]
Length = 1321
Score = 44.3 bits (103), Expect = 8e-04
Identities = 65/293 (22%), Positives = 128/293 (43%), Gaps = 29/293 (9%)
Query: 1009 KQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQ---------K 1059
++ALE+ + AY +P+ A + Y K ++Y +A + + + KI+ K
Sbjct: 746 EKALEVYDEAY-RQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGK 804
Query: 1060 AIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVL--YYLQNNLETADQFLK 1117
+ K + + ++AL+ + + +D P + L +L Y + E + L
Sbjct: 805 LLLKLKKVNKAEKVLKQALEHD---IVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLN 861
Query: 1118 RSLEMRERVLGP---DHPDCAQSLNNLAA-LCNEKKQYDKAEELYERALDIRRRALAPDH 1173
++L+++ R+L + P+ S LAA +C + ++ AE+ Y++A+ + +
Sbjct: 862 KALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSY-L 920
Query: 1174 PSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMK 1233
P+ + LA LY G LD + ++ Q TA V +A L + +
Sbjct: 921 PTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNH--------ETASVLMADLMFRKQ 972
Query: 1234 KHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKR 1286
KH A+ LY + L+ D+ +H + + L+ L FE A ++ R
Sbjct: 973 KHEAAINLYHQVLEKAPDNFLVLHKLI-DLLRRSGKLEDIPAFFELAKKVSSR 1024
>gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo
sapiens]
Length = 1320
Score = 44.3 bits (103), Expect = 8e-04
Identities = 65/293 (22%), Positives = 128/293 (43%), Gaps = 29/293 (9%)
Query: 1009 KQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQ---------K 1059
++ALE+ + AY +P+ A + Y K ++Y +A + + + KI+ K
Sbjct: 745 EKALEVYDEAY-RQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGK 803
Query: 1060 AIKKKGNLYGFALLRRRALQLEELTLGKDTPDNARTLNELGVL--YYLQNNLETADQFLK 1117
+ K + + ++AL+ + + +D P + L +L Y + E + L
Sbjct: 804 LLLKLKKVNKAEKVLKQALEHD---IVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLN 860
Query: 1118 RSLEMRERVLGP---DHPDCAQSLNNLAA-LCNEKKQYDKAEELYERALDIRRRALAPDH 1173
++L+++ R+L + P+ S LAA +C + ++ AE+ Y++A+ + +
Sbjct: 861 KALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSY-L 919
Query: 1174 PSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLYSQMK 1233
P+ + LA LY G LD + ++ Q TA V +A L + +
Sbjct: 920 PTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNH--------ETASVLMADLMFRKQ 971
Query: 1234 KHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEGGDFEKAAELYKR 1286
KH A+ LY + L+ D+ +H + + L+ L FE A ++ R
Sbjct: 972 KHEAAINLYHQVLEKAPDNFLVLHKLI-DLLRRSGKLEDIPAFFELAKKVSSR 1023
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,012,761
Number of Sequences: 37866
Number of extensions: 2283693
Number of successful extensions: 11100
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 349
Number of HSP's that attempted gapping in prelim test: 9761
Number of HSP's gapped (non-prelim): 1460
length of query: 1330
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1216
effective length of database: 13,930,794
effective search space: 16939845504
effective search space used: 16939845504
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.